text:
Washington DC All Destinations
Explore Washington DC
Washington DC Tours
All Washington DC Tours
Things to do in Washington DC
Capitol Hill Tours & Tickets
Washington Monument Tours & Tickets
Arlington National Cemetery Tours & Tickets
Potomac River Tours & Tickets
Mount Vernon Tours & Tickets
Lincoln Memorial Tours & Tickets
U.S. Capitol Tours & Tickets
Washington DC Neighborhood Guide
How to Experience Cherry Blossom Season in Washington DC
Don't Miss These Must-Do Activities in Washington DC
Washington DC Museum Guide
Food Lover's Guide to Washington DC
How to Get Around in Washington DC
Sightseeing on a Budget in Washington DC
Niagara Falls & Around
With free admission to the city's national museums and monuments, Washington DC is an affordable place to soak up some culture. That said, it's still easy to overspend on transport, tours, and dining. Here are a few ways to see more while spending less.
Take a Tour that Includes Transportation
There's so much to see in Washington DC that you don't want to waste time walking from one place to the next or navigating public transport. Instead, book a hop-on hop-off bus or trolley tour that takes you to all the top sights. Or, join a Segway or bike tour to learn about the history of top sights.
Book a Combo Tour
One of the best ways to see Washington DC is on a bus tour. To see the city from two perspectives, book a tour that combines a bus trip with a Potomac River cruise. That way, you get a discounted price for both excursions.
Choose a Tour that Includes Lunch or Tastings
In DC's historic waterfront restaurants,, food and drinks can get expensive. Instead, take a food tour that includes enough tastings to fill you up, and let you get the inside scoop on local culture. Additionally, you can book a brunch or sunset cruise along the Potomac River and see the sights while indulging in an all-you-can-eat meal.
Buy an Attractions Pass
Sightseeing passes such as the Washington DC Explorer Pass are a cost-effective way to enjoy popular attractions and activities such as Mount Vernon, a riverboat cruise, and a hop-on hop-off bus tour. By bundling the attractions together, you can see more without worrying about the price of each individual attraction.
Washington DC Moonlit Tour of the National Mall with Pick-Up & Stops at 10 Sites
See Washington DC's best sites light up after dark on a 3-HourGuided Nighttime Tour of the National Mall and monuments. Listen to an entertaining narrated history of the capital city, then stop to explore the most important destinations, from moving tributes to America's 20th-century wars to inspiring presidential landmarks. Take in the White House and the U.S. Capitol building at their most picturesque and get the perfect orientation and overview of Washington, DC.
Half-Day Grand Sightseeing Tour of Washington DC with Stops at 8 Top Sites
Get a panoramic look at Washington DC on this 4-hour Half Day sightseeing tour that provides a comprehensive introduction to the United States capital and its historical and cultural landmarks. Listen to live narration as you see dozens of attractions, such as Lincoln Memorial, the exterior of the White House, Washington Monument and the National Mall, the Vietnam Veterans Memorial, Arlington National Cemetery, and the Smithsonian buildings. Tour stops at 8 top Attractions including White House, US Capitol, Franklin Roosevelt Memorial, Martin Luther King Memorial, Lincoln Memorial, Korean War Memorial, Vietnam Memorial, and Nurses Memorial. Bonus: Upgrade option available at checkout for those who would like to extend their half-day city hour into an 8-hour full day guided city tour including a visit to George Washington's Mount Vernon.
Best of DC Tour - With Access to US Capitol Grounds & National Archives Building
Beat the long entrance lines and experience some of the most popular attractions in Washington, DC like an insider on this full-day sightseeing tour. Enjoy priority entry into the United States Capitol, the home of Congress. Then visit the National Archives Building, where the original Bill of Rights, the Declaration of Independence and the United States Constitution are on display. In between, see the city's most famous landmarks and monuments, like the White House, the Lincoln Memorial and more.
3-Hour Washington DC "Monuments By Night" Guided Night-Time Sightseeing Bus Tour
Head out after dark to see the iconic monuments of Washington, DC, lit up for the night. This evening tour takes you on a scenic ride past the Capitol, the Washington Monument, the White House, the Lincoln Memorial, and other sites. This tour combines a ride in a tour vehicle with some stops where you'll get out to walk for a closer look. Learn about the history of the sites and ask plenty of questions.
Washington DC in One Day: Guided Sightseeing Tour
Experience the sights and sounds of Washington, DC in one day on this guided walking and riding sightseeing tour around the nation's capital. Visit the city's historic, iconic landmarks and monuments, like the White House, the United States Capitol, the Vietnam Veterans Memorial, and the Lincoln Memorial. See and learn about the memorials of famous American leaders who helped shape the United States, like Abraham Lincoln, Thomas Jefferson, and Martin Luther King, Jr., to name a few. Includes a seasonal Potomac River cruise.
Washington DC Monuments by Moonlight Tour by Trolley
Explore the famous monuments and memorials of Washington DC by moonlight on this narrated sightseeing tour. Hop aboard an open-air trolley and enjoy an educational and entertaining history of the nation's capital while traveling past each point of interest. Take in the stunning views of an illuminated Lincoln Memorial, the Washington Monument, the White House, and many other landmarks. This is a truly unique look at the iconic monuments of Washington DC by night.
Washington DC Premier Dinner Cruise
Enjoy delicious cuisine and live entertainment with a view of Washington, DC on this 2.5-3 hour dinner cruise along the Potomac River. On board the elegant Odyssey cruise ship, choose from one of three exquisitely decorated glass atrium dining rooms or head to the open-air observation deck to admire the view. Dine on a delicious 3-course meal, then dance the night away or see the famous sites of the nation's capital — like the Washington Monument, the Lincoln Memorial, Reagan National Airport and much more under a moonlit sky.
Capitol Hill and DC Monuments Tour by Electric Cart
Explore the famous monuments and war memorials of Washington, DC on this small-group sightseeing tour. Hop aboard a special eCruiser vehicle and enjoy an educational and entertaining narrated history of our nation's capital. Get a glimpse of the White House and travel around and through Capitol Hill, the Smithsonian museum complex, plus a plethora of famous memorials and monuments — like the Lincoln Memorial and Washington Monument — and many other hotspots. This is a great way to see many of DC's most famous landmarks.
Guided Small Group Night Tour Of The National Malls Top Attractions
Washington DC's monuments and landmarks light up after dark, perfect for dramatic views and memorable photos of the capital city. Explore the sights from the National Mall to the White House and key memorials as your guide provides informative narration about each site. Hop off at select sights to get an up-close look with your small-group and guide. This tour includes transport between locations.
Arlington National Cemetery Guided Walking Tour with Changing of the Guards
See the moving Changing of the Guards at the Tomb of the Unknowns on a guided walking tour of Arlington National Cemetery. Be perfectly placed for good views of the moving ceremony, then continue to some of the cemetery's most important gravesites and memorials, including places dedicated to John F. Kennedy, the USS Maine, Second World War soldier Audie Murphy, and more, learning the fascinating history of the cemetery as you walk.
1 hour&nbsp30 minutes to 2 hours
Washington DC Sightseeing Trolley Tour with 1 Stop
Depart from the Washington DC Welcome Center and take a 90 minute Washington DC trolley tour to explore the nation's capital. The route encompasses the city's top attractions, including the White House, Lincoln Memorial and the National Mall.
Washington DC Morning Monuments Sightseeing Bus & Walking Tour with 10+ Stops
See Washington, DC's iconic monuments in a single morning on a 3-Hour Guided Morning Sightseeing Bus & Walking Tour with an experienced guide. Choose a tour that combines walking and travel by air-conditioned coach so you can cover lots of ground with time to see the DC sights up close. Pass by over 20+ sites including Washington Monument, National Archives, Freedom Plaza, Jefferson Memorial and stop for photos outside top locations including the White House, US Capitol, MLK Memorial, and more. Hear insider stories about DC's politicians and historic figures as you explore their moving war memorials, Presidential sites and government buildings, and get the perfect introduction to America's capital city.
Professionally Guided Small Group Day Tour Of The National Malls Top Attractions
Experience the history and culture of the nation's capital on this comprehensive, half-day, small-group tour. Travel in a comfortable vehicle complete with phone chargers, umbrellas, and a flat-screen TV, and see Washington DC's monuments, museums, and memorials with a guide. See the US Capitol building, the White House, the Mall and more. Avoid the hassles of driving, or navigating public transportation and leave the logistics to your guide.
Washington DC Monuments by Moonlight Electric Cart Tour
Explore the famous monuments and war memorials of Washington, DC by the light of night on this small-group sightseeing tour. Hop aboard an open-air, electric vehicle and enjoy an educational and entertaining narrated history of our nation's capital. Travel around and through the plethora of famous memorials and monuments, with stunning views of an illuminated Washington Monument, the White House and many other landmark locations. This is a truly unique look at the iconic monuments of Washington, DC by night.
Washington DC Monuments Bike Tour
See the historical sights of Washington DC with an up-close view of significant monuments on a bike tour by comfortable cruiser. Ride an easy route over flat terrain from the National Mall to the Potomac Tidal Basin and view DC landmarks including the Washington Monument, Vietnam Veterans Memorial, Lincoln Memorial, and Jefferson Memorial as you explore the attractions with a knowledgeable guide.
Sightsee DC with 10+ Stops & Seasonal Potomac River Cruise or Jefferson Memorial
Explore the famous landmarks and monuments of Washington DC on this guided 6-hour walking and riding sightseeing tour. Hop aboard a deluxe motor coach and enjoy an educational and entertaining narrated history of the nation's capital. Stop at the White House and the United States Capitol, plus the Lincoln Memorial, the Vietnam Veterans Memorial, the Martin Luther King, Jr. Memorial and much more. The full-day tour features more than 30 sites with stops to at least 12 sites. It's a great way to see many of DC's popular attractions.
Washington DC After Dark Sightseeing Night-Time Tour with Stops at 8 Top Sites
There's a certain magic to Washington DC that can only be experienced at night. It's a time when the powerful Lincoln Memorial is bathed in soft white light, and the Washington Monument, Capitol, and White House appear even more grandiose. Along with a knowledgeable local guide, take a tour of Washington DC well after the sun has gone down, and feel the buzz, magic, and pulse of America's capital by night.
Washington DC "See the City" Guided Sightseeing Segway Tour
Experience the history and scale of Washington, DC's monuments, museums, and memorials on a Segway tour with plenty of photo opportunities. Avoid long hours of walking between destinations, and see more the city with a guided tour. Headsets insure you can hear your guide's insightful commentary as you whizz past prominent buildings and historic sights. This tour is ideal for visitors who want to get a good overview of the city, in order to know where to explore in more depth later.
George Washington's Mount Vernon & Old Alexandria Half-Day Guided Tour from DC
Venture beyond Washington DC city limits—and explore some of the nation's key historical landmarks—on this half-day coach tour. Pick between morning and afternoon departure times, and set off via the George Washington Memorial Parkway: you'll spy landmarks like the Robert E. Lee Childhood Home, George Washington Masonic National Memorial, and Alexandria's Christ Church. Upon arrival, go for a self-led audio tour of Mount Vernon's grounds and museum. Upgrade at checkout to include Admission into Arlington Cemetery.
Washington DC "Monuments By Morning" Tour
Have only a short stay in Washington DC planned? See the major highlights of the capital all in one morning—this monuments tour makes exploring the city easy. Board your bus near the National Archives building, and get ready to discover dozens of sights. Make a stop at top-tier landmarks like the White House, Lincoln Memorial, Martin Luther King Jr. Memorial, and more—and learn the stories behind the sights from your guide's commentary.
Washington DC Sites at Night Bike Tour
Experience the beauty of Washington, D.C. at night on this monuments at night bike tour of the city. Check out the Jefferson, Lincoln and WWII memorials once the sun goes down and explore the Vietnam War Memorial and the National Mall at night. This popular tour offers travelers the chance to explore on two wheels after dark when monuments are less crowded.
Washington DC "Morning Monuments" Guided City Tour with Arlington Cemetery Entry
This half-day tour of Arlington National Cemetery and the monuments of Washington, D.C. highlights some of the nation's capital's top attractions. Witness the changing of the guard at the Tomb of the Unknowns and visit the grave of John F Kennedy while you listen to informative commentary and get plenty of history and context from your expert guide. This experience also includes a guided bus tour of the National Mall and stops at major landmarks like the Korean War Veterans Memorial, the Vietnam Veterans Memorial, the Martin Luther King Jr. Memorial, White House, State Capitol building and more. This informative tour is the ideal way for first-time visitors to take in the sites and learn about the history, attractions and memorials that make Washington, DC a top destination for travelers from across the globe.
Washington DC Scenic Lunch Cruise
Enjoy food, fun, and entertainment with a view of Washington DC on this narrated lunch cruise along the Potomac River. Onboard the elegant Spirit of Washington, choose to cruise from three air-conditioned interior decks or the rooftop lounge. Either way, the view is spectacular, there's a delicious buffet lunch to enjoy and a DJ is spinning the latest Top 40 hits on spacious dance floors. Look and listen as the captain points out DC's fascinating history while drifting past the Washington Monument, Reagan National Airport and much more.
Washington DC Capital Sites Bike Tour
Washington DC is full of historical sites and while it's easy to explore on foot or by bus, this 2-wheel tour option gives travelers access to some of the city's most popular landmarks. Check out the Lincoln Memorial, White House, Supreme Court and the Capitol on this Capital Sites Bike Tour. Your friendly guide shares plenty of history, facts, and city knowledge on this easy bike ride through the nation's capital.
More Tours in Washington DC
Recommended for Washington DC


Jalpur akhrot also known as walnuts is a produce of USA. Walnuts are used in cakes and toffees. It is specially used in making traditional sweets/desserts, breads, muffins and cookies. They are rich in oil content and are used in cookery, as in garnishing sometimes and could be eaten plain as well.
Although the walnuts are of general good quality, there is a percentage of inedible nuts - possibly 5%.
The quality is generally good but in a kilo there are usually 4 or 5 nuts below the usual standard. On my most recent order, a visual check would seem to indicate an even better quality than those I have received before.


Dermatological capsules can only be used for SPA Multifunctional Shower.
The SPA cosmetic capsules can be placed in the handle of the shower, for those who need some special skin treatment. (dry skin, sensitive skin, burns or other injury, surgery, abscesses, ulcers, eczema, badly healing wounds). The fluid from the capsule dropwise added during to the water. The rinsing of the entire surface of a body is done in one motion and it spreads the aqueous emulsion so that anyone can do their own treatment. The capsule operating mechanism provides an opportunity for the treatment with a more concentrated substance and leaves the vehicle used by creams thereby ensures a more effective treatment.
In the SPA Multifunctional Shower Head is possible to use the Derma Capsule.
This capsule enables specific medication! The capsule is supplied empty so it can be filled as prescribed by your doctor, or with medicine proposed magisterial preparation and carry out skin treatment. While using the capsules the medical fluid is fed to the spray drops, it creates an aqueous emulsion and covers the entire body surface. So in a few seconds of rinsing shower the entire body surface can be treated. This method enables you to use active content to dominate the treatment of fluids and do little to apply a vehicle on our skin, which in addition to being unnecessary, may be harmful by constant use.
The Spa Derma capsules provide help with various dermatological illnesses that are otherwise difficult to treat.


text:
1 file | 2.82 MB
Atmospheric pressure non-thermal plas...
Atmospheric pressure non-thermal plasma assisted polymerization of poly (ethylene glycol) methylether methacrylate (PEGMA) on low density polyethylene (LDPE) films for enhancement of biocompatibility
M.C. Ramkumar, K. Navaneetha Pandiyaraj, A. Arun Kumar, P.V.A. Padmanabhan, Pieter Cools (UGent) , Nathalie De Geyter (UGent) , Rino Morent (UGent) , S. Uday Kumar, V. Kumar, P. Gopinath, et al.
(2017) SURFACE & COATINGS TECHNOLOGY . 329. p.55-67
M.C. Ramkumar, K. Navaneetha Pandiyaraj, A. Arun Kumar, P.V.A. Padmanabhan, Pieter Cools (UGent) , Nathalie De Geyter (UGent) , Rino Morent (UGent) , S. Uday Kumar, V. Kumar, P. Gopinath, S.K. Jaganathan and R.R. Deshmukh
Department of Applied physics
DIELECTRIC BARRIER DISCHARGE, INDUCED GRAFT-POLYMERIZATION, POLY(ETHYLENE GLYCOL), PROTEIN ADSORPTION, ETHER METHACRYLATE, PLATELET-ADHESION, ACRYLIC-ACID, ENDOTHELIAL-CELLS, SURFACES, DEPOSITION
Ramkumar, M.C. et al. "Atmospheric Pressure Non-thermal Plasma Assisted Polymerization of Poly (ethylene Glycol) Methylether Methacrylate (PEGMA) on Low Density Polyethylene (LDPE) Films for Enhancement of Biocompatibility." SURFACE & COATINGS TECHNOLOGY 329 (2017): 55–67. Print.
Ramkumar, M. C., Navaneetha Pandiyaraj, K., Arun Kumar, A., Padmanabhan, P. V. A., Cools, P., De Geyter, N., Morent, R., et al. (2017). Atmospheric pressure non-thermal plasma assisted polymerization of poly (ethylene glycol) methylether methacrylate (PEGMA) on low density polyethylene (LDPE) films for enhancement of biocompatibility. SURFACE & COATINGS TECHNOLOGY , 329, 55–67.
Ramkumar, M.C., K. Navaneetha Pandiyaraj, A. Arun Kumar, P.V.A. Padmanabhan, Pieter Cools, Nathalie De Geyter, Rino Morent, et al. 2017. "Atmospheric Pressure Non-thermal Plasma Assisted Polymerization of Poly (ethylene Glycol) Methylether Methacrylate (PEGMA) on Low Density Polyethylene (LDPE) Films for Enhancement of Biocompatibility." Surface & Coatings Technology 329: 55–67.
Ramkumar, M.C., K. Navaneetha Pandiyaraj, A. Arun Kumar, P.V.A. Padmanabhan, Pieter Cools, Nathalie De Geyter, Rino Morent, S. Uday Kumar, V. Kumar, P. Gopinath, S.K. Jaganathan, and R.R. Deshmukh. 2017. "Atmospheric Pressure Non-thermal Plasma Assisted Polymerization of Poly (ethylene Glycol) Methylether Methacrylate (PEGMA) on Low Density Polyethylene (LDPE) Films for Enhancement of Biocompatibility." Surface & Coatings Technology 329: 55–67.
Ramkumar MC, Navaneetha Pandiyaraj K, Arun Kumar A, Padmanabhan PVA, Cools P, De Geyter N, et al. Atmospheric pressure non-thermal plasma assisted polymerization of poly (ethylene glycol) methylether methacrylate (PEGMA) on low density polyethylene (LDPE) films for enhancement of biocompatibility. SURFACE & COATINGS TECHNOLOGY . Elsevier BV; 2017;329:55–67.
M. C. Ramkumar et al., "Atmospheric pressure non-thermal plasma assisted polymerization of poly (ethylene glycol) methylether methacrylate (PEGMA) on low density polyethylene (LDPE) films for enhancement of biocompatibility," SURFACE & COATINGS TECHNOLOGY , vol. 329, pp. 55–67, 2017.
author       = {Ramkumar, M.C. and Navaneetha Pandiyaraj, K. and Arun Kumar, A. and Padmanabhan, P.V.A. and Cools, Pieter and De Geyter, Nathalie and Morent, Rino and Uday Kumar, S. and Kumar, V. and Gopinath, P. and Jaganathan, S.K. and Deshmukh, R.R.},
journal      = {SURFACE & COATINGS TECHNOLOGY },
keywords     = {DIELECTRIC BARRIER DISCHARGE,INDUCED GRAFT-POLYMERIZATION,POLY(ETHYLENE GLYCOL),PROTEIN ADSORPTION,ETHER METHACRYLATE,PLATELET-ADHESION,ACRYLIC-ACID,ENDOTHELIAL-CELLS,SURFACES,DEPOSITION},
publisher    = {Elsevier BV},
title        = {Atmospheric pressure non-thermal plasma assisted polymerization of poly (ethylene glycol) methylether methacrylate (PEGMA) on low density polyethylene (LDPE) films for enhancement of biocompatibility},
url          = {http://dx.doi.org/10.1016/j.surfcoat.2017.09.020},
SURFACE & COATINGS TECHNOLOGY
Elsevier BV
10.1016/j.surfcoat.2017.09.020
MATERIALS SCIENCE, COATINGS & FILMS
4/19 (2017)

redpajama_set_name: RedPajamaCommonCrawl


Special occasions demand special looks, and we make it happen. From your initial consultation, to practise trials and your final perfect look, we are committed to giving you a true VIP experience.
We can create your look either in house, or at the location of your choice. Prices on consultation. Please contact the team for more information.


Sore and cracked toes and toenails can be a constant source of pain and embarrassment. New NailFIX™ maintenance programme gets to work straight away, softening toenails and skin, disinfecting and reducing pain and swelling - and allowing full strong growth and attractive feet and hands as the nail beds grow out.
NAILFIX is an analgesic and disinfectant. A few drops applied twice daily on an ingrown nail, thick toenails, inflamed nails and skin will relieve pressure and clear infection, softening the nail and the surrounding hard skin. Nailfix should be used daily until the problem area has been sorted. Ingrown Toenails because of the nature of the problem can take up to 6 months to clear completely! Other problems such as itchy, inflamed skin can be treated in days so always keep a bottle of Nailfix to hand ready to apply the moment any problems appear!
Simply apply the oil twice a day to the infected toenail.
1 bottle will treat 1 foot for 30 days. 2 bottles will treat 2 feet for 30 days. If you have several infected toenails we recommend you purchase the 3 bottle option.


This platform presents the current TV guide, together with all kinds of exclusive reports and background stories from the world of TV and cinema. Pure entertainment, available in a compact or highly detailed format – with just a few clicks, the electronic programme guide (EPG) enables the user to select how they would like to view the desired information. A mobile version can also be accessed on a tablet PC or iPhone. It's incredibly easy to organise the programme according to times, channels or interests. After a one-off registration on wilmaa.com, users can also watch their selected films live on tele.ch (live TV).


text:
In Memoriam 1942 – 2013 "Roger Ebert loved movies."
Chaz's Journal
Far Flungers
The film, while well-made on a technical level, feels more like a collection of moments than a full and satisfying narrative.
A thorough and thoroughly conventional, look at the first astronaut to set foot on the moon.
Roger Ebert on James Ivory's "Howards End".
Ballad of Narayama
"The Ballad of Narayama" is a Japanese film of great beauty and elegant artifice, telling a story of startling cruelty. What a space it opens…
Veronika Voss
Spirit of the Beehive
Great Movie Archives
Fly Me to the Moon: 50th Anniversary of Apollo 11 and Man's Walk on the Moon
Chaz's Journal | by Chaz Ebert
The writers at RogerEbert.com share their favorite moon-related songs, movies and events to celebrate the 50th anniversary of man's walk on the moon.
Video: Roger Ebert Day Declared in Chicago on July 12th, 2005
A video featuring Chicago City Council declaring Friday, July 12th, 2005, as Roger Ebert Day in Chicago.
Roger Ebert's Typewriter on Display at University of Illinois | Chaz's Journal
Happy Birthday, Roger: A Celebration of Our Favorite Writing | Chaz's Journal
My Favorite Roger: Brian Tallerico | Chaz's Journal
Chaz's Journal Archives
The Unloved, Part 67: Mortal Engines | MZS
On the President's Orders Plays at Human Rights Festival
Far Flungers | by Michael Mirasol
A piece on the premiere of a film about Rodrigo Duterte.
That Complicated Thing Called Love: On Pawel Pawlikowski's Cold War
Far Flungers | by Seongyong Cho
One of our foreign correspondents looks at Cold War.
The Hustler | Far Flungers
4 Months, 3 Weeks, 2 Days | Far Flungers
Every Day's a Brand New Deal: On American Splendor | Far Flungers
Far Flunger Archives
Fantasia 2019: Bruce McDonald's Dreamland, Look What's Happened to Rosemary's Baby
Festivals & Awards | by Nick Allen
Reviews from the Fantasia Film Festival of the beguiling hitman story Bruce McDonald's Dreamland, and a special presentation of a rare horror sequel.
Old Friends Who've Just Met: Dave Goelz on The Muppet Movie, The Dark Crystal: Age of Resistance and Much More
Interviews | by Matt Fagerholm
An interview with Dave Goelz, a.k.a. Gonzo in "The Muppet Movie," which returns to theaters on July 25th and July 30th, courtesy of Fathom Events.
NALIP Honors AAFCA with its 2019 We Are Inclusion Award | Festivals & Awards
Japan Cuts 2019 Preview | Festivals & Awards
Bright Wall/Dark Room July 2019: Only I Know the Secrets: Breaking Down Under the Silver Lake by Ethan Warren | Balder and Dash
Channel Archives
The Honeymooners (2005)
Cedric The Entertainer as Ralph Kramden
Mike Epps as Ed Norton
Regina Hall as Trixie Norton
Gabrielle Union as Alice Kramden
Eric Stoltz as William Davis
John Leguizamo as Dodge
Danny Jacobson
David Sheffield
Barry W. Blaustein
Don Rhymer
Rated PG-13 for some innuendo and rude humor
| Roger Ebert
June 9, 2005 |
Print Page Tweet
"The Honeymooners" is a surprise and a delight, a movie that escapes the fate of weary TV retreads and creates characters that remember the originals, yes, but also stand on their own. Playing Ralph Kramden and Ed Norton, Cedric the Entertainer and Mike Epps don't even try to imitate Jackie Gleason and Art Carney; they borrow a few notes, just to show us they've seen the program, and build from there. And Gabrielle Union and Regina Hall, as Alice and Trixie, flower as the two long-suffering wives, who in this version get more story time and do not ever, even once, get offered a one-way ticket to the moon. Instead, Ralph even sweetly promises Alice he will "take her to the moon," although to be sure that's when he proposes marriage.
The externals of the movie resemble the broad outlines of the TV classic. The Kramdens live downstairs, the Nortons live upstairs; Ralph drives a bus, Ed is proud of his command of the sewer system's scenic routes. Ralph is a dreamer who falls for one get-rich-quick scheme after another, and the closet is filled with his failed dreams: the Pet Cactus, the Y2K Survival Kit. His wife, Alice, is the realist. All she wanted when she got married was to live in a home of their own. They're still renting.
Cedric is funny in the role, yes, but he's also sweet. He understands the underlying goodness and pathos of Ralph Kramden, who is all bluff. Epps makes Norton into a sidekick like Sancho Panza, who realizes his friend is nutty but can't bear to see him lose his illusions.
The plot: Alice and Trixie, who work as waitresses at a diner, meet a sweet little old lady who wants to sell her duplex at a reasonable price. They're up against a wily real estate king (Eric Stoltz) who wants to turn the whole block into condos, but if they can come up with a $20,000 down payment, the house is theirs. That means $10,000 from the Kramdens, who have $5,000 in the bank; Alice thinks maybe she can borrow the rest from her mother (Carol Woods), a fearsome force of nature who served in Vietnam, was a Golden Gloves champ and despises her son-in-law (her advice to Ralph on eating his dinner: "When you get to the plate, stop.").
There is a problem with Alice's financial plan. The problem is Ralph has spent all the money on a series of failed dreams. Desperate to raise cash, Ralph and Ed try hip-hop dancing in the park, at which they are very bad, and begging as blind men, at which they are worse. Then they find a greyhound dog in a trash bin and decide to race it at the dog track.
Enter John Leguizamo as Dodge, a "trainer" recommended by the track's shady owner (Jon Polito). Leguizamo is optimistic ("I started with nothing and still have most of it left") and fancies himself a Dog Whisperer, but Izzy the dog doesn't seem to understand the principle behind racing, which is that he has to leave the gate and run around the track. Ralph, however, believes in the "homeless dumpster dog," and in a big scene describes him as "a survivor ... like Seabiscuit, Rocky and Destiny's Child."
All of this is handled by the director John Schultz ("Like Mike") with an easygoing confidence in the material. There's nothing frantic about the performances, nothing forced about the plot; the emphasis is on Ralph's underlying motive, which is to prove to Alice that he is not invariably a failure and can buy her a house one way or another. That was the secret of Gleason's "Honeymooners" -- Ralph lost his temper and ranted and raved, but he had a good heart, and Alice knew it.
The supporting performances bring the movie one comic boost after another. Leguizamo's con man dog trainer is an invention in flim-flammery, Polito's track owner is an opportunist, Stoltz finds just the right slick charm as the real estate sharpie and Woods is the mother-in-law Ralph Kramden deserves for his sins. Hall and Union spend a lot of their scenes with each other while the boys are out getting in trouble. They provide the engine that drives the movie's emotions: They want that house, they have a deadline to meet, and Ralph grows increasingly desperate because he doesn't want to let Alice down yet again.
I was afraid Cedric the Entertainer and Mike Epps would try to imitate Gleason and Carney. Not at all. What they do is work a subtle tribute to the earlier actors into new inventions of their own. Cedric has that way of moving his neck around inside his collar that reminds us of Gleason, and the slow burn, and the wistful enthusiasm as he outlines plans that even he knows are doomed. Epps has the hat always hanging on at an angle, the pride in the sewer system, the willingness to go along with his goofy pal. And the movie's story actually does work as a story and not simply as a wheezy Hollywood formula. Sometimes you walk into a movie with quiet dread and walk out with quiet delight.
The Unloved, Part 67: Mortal Engines Scout Tafoya
A video essay about Mortal Engines, as part of Scout Tafoya's ongoing video essay series on maligned masterpieces.
Stranger Things Returns with Phenomenally Entertaining Third Season Brian Tallerico
This is the most purely entertaining season of Stranger Things to date.
From Blue Velvet to Top Gun: J. Hoberman on Movie Culture in the Reagan Era Patrick Z. McGavin
An interview with the legendary critic J. Hoberman on the release of his book Make My Day.
Reveal Comments
The Ebert Club is our hand-picked selection of content for Ebert fans. You will receive a weekly newsletter full of movie-related tidbits, articles, trailers, even the occasional streamable movie. Club members also get access to our members-only section on RogerEbert.com
Premiere Member : $20.00USD - yearly
Why Critics Should See Bad Movies
by Pete Croatto
"1941": An Appreciation and Interview with Bob Gale
by Peter Sobczynski
Elaine Stritch: 1925-2014
by Odie Henderson
Sea of Shadows
Trespassers
Into the Dark: Culture Shock
The Chambermaid
The Other Story
The Plagiarists
Three Peaks
Burn Your Maps
Nightmare Cinema
The Quiet One
Being Frank
Framing John DeLorean
Into the Dark: They Come Knocking
Papi Chulo
The Lavender Scare
The Raft
This One's for the Ladies
MZS
Balder and Dash
Demanders
Tributes to Roger
Opening Shots Project
© Copyright 2019, Ebert Digital LLC
Movies by Letter


CardSave is a member of the WorldPay group, one of the UK largest payment providers. It has a client membership of more than 40 thousand small and large businesses and provides you with the benefits of a secure, efficient payment processing, and excellent personal customer service.
With the Cardsave extension, integrations with Cardsave system is as simple as entering your account credentials and specify what your payment page will require from your customer. 1 minute of work that's all, you will be ready to accept payments with Cardsave.
CardSave gateway extension uses the redirect payment flow. Your customers will be redirected to the CardSave website to make a payment and returned back to you site for a confirmation. Since the payment process is handled by CardSave, SSL certificate is not required for your website.


text:
Bionoblatta är ett släkte av kackerlackor. Bionoblatta ingår i familjen jättekackerlackor.

Kladogram enligt Catalogue of Life:

Källor

Jättekackerlackor
Bionoblatta

redpajama_set_name: RedPajamaWikipedia


Today on the BlueBird Podcast I speak to Ryan McKenzie who used his experience in the magazine publishing industry to build a successful subscription box business by offering superior value and a community to his customers.
Ryan published an article on LinkedIn that described his expectations and experience with starting a subscription box business. His piece triggered a lot of interest because his idea seems to be very brave and the way he openly describes what he learned is very impressive.
I invite you to listen to episode 20 of the BlueBird Podcast and let me know what you think in the comments.
Ryan McKenzie is one of the partners of My Passion Media and the VP of Canada Wide Media. You might have seen the magazines these companies publish.
They have used their experience and network in the subscription space to add subscription boxes to the mix. These boxes contain "surprise" products that are sent out to subscribers usually every 90 days.
By offering a community and added value to the subscribers, the number of subscribers to each box keeps growing and very few people leave.
Learn more about subscription boxes by listening to the podcast.
I hope you enjoyed this episode of the BlueBird Podcast! I would like to know where you found this podcast. Please leave a comment about how you found this in the comments or send me an email to [email protected].


On the wall of my bedroom, I have a rather large frame. It holds a certificate stating that I had been inducted into the "Distinguished Order of the Servant-Leader" in October of 2005. I and a friend of mine, Wes Ransom, were among the first civilian college students to have received the award in anyone's memory. Needless to say, I was quite proud of myself. But, there was one thing missing. My best friend wasn't there. You see, Josh was embarking on a different journey. That hot, humid Sunday afternoon in the Georgia fall, Josh was leaving behind the safe confines of our hometown to embark on what is, for anyone, a life altering journey. He was on his way to a small island off the coast of South Carolina where they make Marines.
A few months later, I did get a visit from Josh on campus. After he finished his initial training, the Marine Corps sent him back to recruit. One of his stops was Georgia Military College. Never would have I expected then what was to take place in the coming years.
I graduated from GMC, then went on to Georgia College. Josh graduated School of Infantry, then joined the fleet with the 3rd Battalion 6th Marines in Camp Lejeune, North Carolina. He went on to complete two tours of duty in Iraq before completing his contract to the Corps and transferring to inactive reserves.
Josh surprised me when he did not reenlist, and instead he decided to go college. By this time, I was in grad school. He had decided he wanted to go into physical therapy and begin his studies at my alma mater, Georgia Military College along with his younger brother, Jake, who was studying history.
Joshua S. Rogers is a full-time commuter student who is without parallel among his graduating peers. He is the quintessential scholar/leader who has maintained a 4.00 GPA while completing his studies at GMC in an Associate in Science in General Studies. The habit of success is one of the cornerstones of Joshua's way of life and he's shown good academic and character traits from the first day he stepped on this campus. He is a positive example and inspiration for his fellow students and even the faculty in his classes. Mr. Rogers is a member of Phi Theta Kappa, the junior college honor society for academic success and servant leadership, and can be seen on any given day providing assistance to his fellow students all around the GMC campus. Mr. Rogers exemplifies the three words to live by that GMC emphasizes by his consistent display of Duty, Honor, Country. Joshua enlisted in the USMC in 2005 and eventually rose to the rank of Sergeant. As a Corporal of Marines he served as a fire team leader in combat in Iraq from January – July 2007 and moved up to squad leader from March 2008 – October 2008. It is a rare thing to have a student in our classes that has been through the crucible of combat , who has been truly tested in matters of life and death, yet he is one of the gentle scholars who brings such honor and humility to our campus. Joshua now brings his maturity and critical thinking skills to every aspect of his association with GMC and is most deserving of the highest recognition GMC can bestow on it students.
He is a true scholar that adds intellectual rigor to the course of study for all his classmates. His cultural literacy, higher order of thinking skills, and desire for knowledge mark him among the top ONE percent of students I have ever known in my academic career. In class he embodies all the characteristics of a standout leader and role model. He also thinks beyond the material and brings his own intellectual and deeply spiritual perspective to discussions.
I will be there tonight. I will be in my robe, my hood, my stole, and my cords. Josh will be in his Dress Blues. I know his parents will be proud. But, I also know that the pride they have for Josh's accomplishments will at best be equal to the pride I have for him, to know him, and the honor I have in calling him my friend.
Jake, me, and Josh at a friend's wedding a few years ago.
Here is a picture from after the commencement ceremony.
Daniel, I've met your Mama thru Facebook. I graduated high school with your Daddy. Fine people all. I've heard about your through your Mama and know her pride in you. This is a beautifully written, heart-string-tugging article. Good job! Academically AND literally. God bless you.


text:
Q: bindService force closes I'm fairly new to Android programming and to Java in general, but I have extensive experience as a system-level C coder.  I wanted to create an API or library that could be used by a suite of Android apps that I plan to develop and, after much research, decided that a bound service was the Android way of doing that (I would have normally created a .so or a .dll).  If this assumption is incorrect, then my entire question could very well be moot.
At any rate, I created my service's framework in one project and I created an activity in another to test the service.  I stubbed out the service's handleMessage() method with calls to Toast just to see if it was working and then added two buttons to my activity: one to bind the service and the second to unbind it.  After about an hour of not being able to run my activity because it couldn't see my service, I figured out how to get Eclipse to see the source code of the service from the activity and thought I was well on my way.  Then I ran the activity.
Everything looked good.  Two buttons, one to bind, one to unbind.  However, when I pressed the bind button, it force closed the app.  I used the debugger to see what was going on and it is force closing on the bindService() call in my activity.  Of course, the bindService() call was copied from another example in which a new Intent() was created on the same line, so I separated out the two lines of code and it is really dying when I attempt to create the Intent.
Here is the code for my activity:
package net.william.android.myAPI.tester;

import net.william.android.myAPI.MyApiService;
import android.app.Activity;
import android.content.ComponentName;
import android.content.Context;
import android.content.Intent;
import android.content.ServiceConnection;
import android.os.Bundle;
import android.os.IBinder;
import android.view.View;
import android.widget.Toast;

public class MyApiTester extends Activity
{
    boolean mIsBound = false;

    private ServiceConnection mConnection = new ServiceConnection()
    {
        public void onServiceConnected(ComponentName className, IBinder service)
        {
            Toast.makeText(FaceClientTester.this, "Remote Service Connected", Toast.LENGTH_SHORT).show();
        }

        public void onServiceDisconnected(ComponentName className)
        {
            Toast.makeText(FaceClientTester.this, "Remote Service Disconnected", Toast.LENGTH_SHORT).show();
        }
    };

    public void doBindService(View view)
    {
        if (!mIsBound)
        {
            Toast.makeText(this, "Binding Service", Toast.LENGTH_SHORT).show();
            Intent myIntent = new Intent(MyApiTester.this, MyApiService.class);
            bindService(myIntent, mConnection, Context.BIND_AUTO_CREATE);
            mIsBound = true;
        }
    }

    public void doUnbindService(View view)
    {
        if (mIsBound)
        {
            unbindService(mConnection);
            mIsBound = false;
            Toast.makeText(this, "Service Unbound", Toast.LENGTH_SHORT).show();
        }
    }

    @Override
    public void onCreate(Bundle savedInstanceState)
    {
        super.onCreate(savedInstanceState);
        setContentView(R.layout.main);
        return;
    }
}

This is the code for my service:
package net.william.android.myAPI

import android.app.Service;
import android.content.Intent;
import android.os.Handler;
import android.os.IBinder;
import android.os.Message;
import android.os.Messenger;
import android.widget.Toast;

public class MyApiService extends Service
{
    static final int API_FN_1   = 101;
    static final int API_FN_2   = 102;

    class MyApiHandler extends Handler
    {
        @Override
        public void handleMessage(Message msg)
        {
            switch (msg.what)
            {
                case API_FN_1:
                    ApiFn1();
                    break;
                case API_FN_2:
                    ApiFn2();
                    break;
                default:
                    super.handleMessage(msg);
                    break;
            }
        }
    }

    final Messenger myMessenger = new Messenger(new MyApiHandler());

    @Override
    public void onCreate()
    {
        Toast.makeText(this, "Service Started", Toast.LENGTH_SHORT).show();
    }

    @Override
    public void onDestroy()
    {
        Toast.makeText(this, "Service Stopped", Toast.LENGTH_SHORT).show();
    }

    @Override
    public IBinder onBind(Intent intent)
    {
        Toast.makeText(this, "Service Bound", Toast.LENGTH_SHORT).show();
        return myMessenger.getBinder();
    }

    private void ApiFn1()
    {
        Toast.makeText(this, "API Function 1", Toast.LENGTH_SHORT).show();
        return;
    }

    private void ApiFn2()
    {
        Toast.makeText(this, "API Function 2", Toast.LENGTH_SHORT).show();
        return;
    }
}

I changed some of the names of things, but that's really the meat of my code so far.  Just a bunch of calls to Toast so that I could hopefully see that the thing is working.
All of the tutorials that I have found on the subject have completely ignored the manifest.  I poked around a little last night trying to tweak manifest options thinking that that might have something to do with it, but to no avail.  At any rate, for completeness, the following is the manifest code for the activity:
<?xml version="1.0" encoding="utf-8"?>
<manifest xmlns:android="http://schemas.android.com/apk/res/android"
    package="net.william.android.myAPI.tester"
    android:versionCode="1"
    android:versionName="1.0">
    <uses-sdk android:minSdkVersion="10" />
    <application android:icon="@drawable/icon" android:label="@string/app_name">
        <activity android:name=".MyApiTester" android:label="@string/app_name">
            <intent-filter>
                <action android:name="android.intent.action.MAIN" />
                <category android:name="android.intent.category.LAUNCHER" />
            </intent-filter>
        </activity>
    </application>
</manifest>

and the service:
<?xml version="1.0" encoding="utf-8"?>
<manifest xmlns:android="http://schemas.android.com/apk/res/android"
    package="net.william.android.myAPI"
    android:versionCode="1"
    android:versionName="1.0">
    <uses-sdk android:minSdkVersion="10" />
    <application android:icon="@drawable/icon" android:label="@string/app_name">
        <service android:name=".MyApiService"></service>
    </application>
</manifest>

I tried adding the following inside of the <service> block, but it didn't seem to help:
            <intent-filter>
                <action android:name="net.william.android.myAPI.MyApiService" />
            </intent-filter>

Anyway, this is my first post to your forum, so I apologize if there is too much or too little information, or if I missed some really easy fix out there somewhere on the web.  I've been up most of the night reading all of the documentation on services that Google had and reading post after post in forums, so, at this point, I could very easily overlook something.  Thanks in advance to anyone who finds the time to help!

A: If these are to be distributed as two separate APK files, as indicated via your pair of manifests, you cannot use the Intent constructor that takes a Java class as a parameter. The fact that this even compiles indicates your project setup is somewhat scary -- your client should not be within a country mile of your service from a build-time standpoint.
Add an <intent-filter> to your <service> advertising how you want to be connected to, and use that structure in your client for the Intent it creates.
For example, in this pair of sample projects, the service has:
<service android:name=".BshService">
    <intent-filter>
        <action android:name="com.commonsware.android.advservice.IScript" />
    </intent-filter>
</service>

and the client therefore uses:
new Intent("com.commonsware.android.advservice.IScript")

redpajama_set_name: RedPajamaStackExchange


Share Google Chrome with your friends !
What is new in Google Chrome?
Get more done with the new Google Chrome on iPhone and iPad. Now more simple, secure and faster-than-ever, with Google Smarts built-in.
• FASTER BROWSING - Chrome's address bar uses Google Search to make any fact-finding mission fast and simple. It also searches your Google Drive, so diving into next week's vacation plan is just that much easier.
• ARTICLES FOR YOU - Chrome surfaces articles, blogs, and content that we think you might like. The more you use Chrome, the more personalized it gets. So you'll always have what's most relevant to you at your fingertips.
• GOOGLE TRANSLATE - No matter where you are on the web, or the globe, Chrome lets you translate an entire site in a single click with Google Translate built-in. Chrome also automatically prompts translation when you need it.
• MANAGE YOUR TABS - open as many tabs as your heart desires and manage them in the new grid shapes to easily view and compare websites.
• SYNC ACROSS DEVICES - Signing into Chrome automatically syncs across your laptop, tablet, or on your phone. You get the same experience – no matter where you go.
• AUTOFILL FORMS & PASSWORDS - Remembering p4$$w0rd$ is a thing of the past. Chrome can store your address and payment details, so you can fill out forms with just one click.


text:
Unín es un municipio del distrito de Skalica en la región de Trnava, Eslovaquia, con una población estimada a final del año 2017 de .

Se encuentra ubicado al norte de la región, en los pequeños Cárpatos y cerca del río Morava (cuenca hidrográfica del Danubio) y de la frontera con la República Checa.

Referencias

Enlaces externos

Municipios del Distrito de Skalica


text:
Q: Turning an ASP.NET Website into an AJAX-Enabled one I have successfully downloaded and installed AJAX framework, and the control toolkit.
While trying to insert any AJAX controls such as UpdatePanels or ScriptManagers into an existent ASP.NET Web Site (which currently has no AJAX functionalities) I get the following error:
"Attempret do read or write protected memory. This is often an indicator that other memory is corrupt."
So as a test, I've created a brand new project, as an ASP.NET AJAX-Enabled Web Site, as follows:

And in the default page of this project there is an ScriptManager already, and I've been able to insert an UpdatePanel, do a little test with a label and a button updating its content to the current time.
The question is: What does an "ASP.NET AJAX-Enabled Web Site" have that an "ASP.NET Web Site" does not that prevents me from adding AJAX controls ?

A: Do you have more than one version of the AJAX libraries. Often times, the versions can be different between what you have set to use in the configuration file and the controls you are slapping on the page. That is the first place I would check.
You also need to make sure you have the correct version of both AJAX and the control library. This can be you downloaded an old control kit and are using the latest .NET framework, as much of the AJAX functionality has been included in .NET 4.0. Or it can be downloading newer bits and trying to use them with 2.0.

A: As far as I remember (it's been a while since I used AjaxControlToolkit) this error occurs when you attempt to modify the response stream from your code behind (ie: perform a Response.Write(); , or Response.End(); etc etc...
if the method your AsyncPostback trigger is calling is doing any kind of response stream modification then comment it out and try it again as a "proof of concept"..
hopefully this gets you going on the right track.
Dave


text:
module Metaforce
  class Login
    def initialize(username, password, security_token=nil)
      @username, @password, @security_token = username, password, security_token
    end

    # Public: Perform the login request.
    #
    # Returns a hash with the session id and server urls.
    def login
      response = client.call :login, :message => { :username => username, :password => password }
      response.body[:login_response][:result]
    end

  private

    # Internal: Savon client.
    def client
      args = {
        :wsdl => Metaforce.configuration.partner_wsdl,
        :endpoint => Metaforce.configuration.endpoint
      }
      @client ||= Savon.client args do |opt|
        opt.ssl_verify_mode :none
        opt.ssl_version :TLSv1
      end
    end

    # Internal: Usernamed passed in from options.
    def username
      @username
    end

    # Internal: Password + Security Token combined.
    def password
      [@password, @security_token].join('')
    end
  end
end

redpajama_set_name: RedPajamaGithub


text:
ITI Statuten
Costs and Financial Aid
Current Student Body
Liturgical Life
Formation Program
Abuse Prevention and Reporting
Giving & Fees
Defending Catholic "Distinctives" Against Protestant Attacks
Todd Aglialoro
I am Todd Aglialoro and a graduate of the MTS program (1998). As director of publishing for Catholic Answers, I oversee all of the print, online, and audio publication efforts of our apostolate.
Unlike in many Catholic countries of Europe, the United States has a long tradition of Protestant anti-Catholicism, from both the old established churches and modern Evangelicalism and Fundamentalism. As an apostolate of Catholic apologetics and evangelization, Catholic Answers carries on the Anglo apologetics tradition that began in England in the 19th century: defending Catholic "distinctives" against Protestant attacks.
Increasingly, our work is directed towards other rivals to the Faith, including secularism, indifferentism, moral relativism, and cultural attacks on chastity and human life. The conflict with Protestants hasn't disappeared, but the challenge from unbelievers—and from a hostile secular state—is getting stronger. And then, of course, there is the perpetual need to answer the call of the New Evangelization: helping Catholics to re-discover the Faith and be able to articulate it more confidently.
My part begins with Catholic Answers Press, which publishes books, booklets, and audio products aimed at helping Catholics to explain and defend the Faith. Many of these have been translated and published in countries of Central and Eastern Europe, which makes my heart glad. We also publish Catholic Answers Magazine in a bimonthly print format and a daily online format (www.catholic.com). In print since 1987, it is the preeminent magazine of Catholic apologetics in the English language.
It might seem at first that the ITI—an institute focused on marriage and family and devoted to placid contemplation of sacred truths—would not be an especially profitable preparation for the sometimes polemical world of apologetics. But for me, I think it has been. First, because the ITI's focus on original sources translates well to apologetics, where Scripture and the Fathers provide the most important data for reasoning with non-Catholic Christians. Secondly, the rigor of the seminar method, with its emphasis on clear thinking and communication, is a useful preparation for such reasoning and yes, occasional disputation!
I am also happy to say that my ITI formation helped me write a booklet on marriage that Catholic Answers Press has published and distributes both to individuals and to parishes for marriage preparation. I was also strongly moved by my ITI experience to edit a scholarly volume, Inseparable, in defense of Humanae Vitae for that encyclical's 50th anniversary in 2018.
Showing the Perennial Truth of Love in a Post-Modernist Culture
Apply now Donate now
Providing a Mouthpiece for the ChurchGoing Beyond the Covers of the Books We Read
Katholische Hochschule ITI
Schloss Trumau
2521 Trumau (AUSTRIA)
Telephone: +43 2253 218 08
Sign up for emails about
© 2007-2022 Katholische Hochschule ITI
Site notice ENG
Site notice DE
Site by INFOUND


The SOLENTO V is a comfortable and versatile visitor chair that is ideal for conferences and meetings. The cantilever chair has a sturdy and durable steel frame, which, thanks to its slightly springing movement, ensures optimum seating comfort. High-quality components, such as the ergonomically shaped backrest made of breathable mesh, and the comfortable padded seat complete the advantages of this chair. Your guests are welcome to take a seat on the SOLENTO V.
The ergonomically shaped backrest with breathable mesh ensures a pleasant climate even when sitting for a long time.
Dimensions: Height (total): 101 cm; Width (total): 63.5 cm; Depth (total): 58 cm; Seat height: 46 cm; Seat width (usable): 48 cm; Seat depth (usable): 48 cm; Backrest height: 55 cm; Armrest height (measured from the seat): 18 cm; Load capacity (maximum): 150 kg. * All dimensions in unloaded condition.


Happy Socks is a Swedish brand for colorful socks & underwear and features an almost endless variety of models and designs, using a broad spectrum of color combinations and original patterns. With the vision to spread happiness by turning an everyday essential into a colorful design piece, Happy Socks are sold today in more than 90 countries and on every continent. Simply put: there's a pair of high-quality socks and underwear for every occasion, mindset and style.
Terms and Conditions apply. See website for details. Cannot be combined with any other offer. Excludes the purchase of outlet items, limited editions & gift cards. Shipping will take 4-6 business days.


text:
Graphic by Christi Lazutkin | Mercury Staff.
Breaking glass ceilings at UTD
Anna Schaeffer
A climate survey of UTD faculty sheds light on parental leave and gender parity regarding women in the workplace.
In 2016, a survey sent out to all of the university's faculty and staff addressed diversity in gender, ethnicity and other topics. Of UTD employees, about 27 percent responded to the survey. According to the report, there were major concerns about parental leave and diversity in the faculty ranks. Survey respondents said the parental leave policy is poorly designed; others said there are far too few women in administrative positions of power.
Public and Nonprofit Management Associate Professor Meghna Sabharwal researches the glass ceiling: an invisible barrier preventing female employees from reaching positions of power. She said a 2016 Diversity and Equity Committee climate survey of women — both staff and faculty — on campus clearly revealed that gender inequity within UTD is not a myth.
Universities sometimes have an option for tenure-track professors who are new parents to "stop the tenure clock," or essentially hit "pause" on their tenure. However, research by the Institute for the Study of Labor shows that male faculty, rather than new mothers, are the actual beneficiaries of the policy. Sabharwal said she was advised by a female colleague to not stop her tenure clock; other female faculty recommended not having children during tenure because it's just too difficult.
"I was told that I will be judged more in a negative light because now they would say, 'She had extra years, she probably should've published.' The standards will be changed," Sabharwal said.
Sociology professor Sheryl Skaggs, who researches gender in the workplace, said UTD needs an improved parental leave policy because a lot of scenarios are handled on a case-by-case basis.
Although there is a parental leave policy providing 12 weeks of leave, the semester is 16 weeks long; this situation leaves parents, usually women, with four weeks of work in a semester. One survey respondent said the maternal leave policy does not work for faculty, and the dean or department head can either work with faculty or make it very difficult to take leave.
"I was actually told by HR that I could not take 16 (which would be a semester and make sense), even though I had the sick time saved up," the respondent on the survey said. "Here, we need to beg with our administrators to find work-arounds and piece something together. It does not put women in a place of strength. I do not know one woman at this university who would say that our policy works — at all."
Benefits Administrator Celeste Burnett said new parents are always entitled to parental leave under Texas' Family and Medical Leave Act policy.
"Where the questions have come in is when they're teaching in the classroom, which is usually a 15-week teaching assignment, so that makes it harder for them to return to the classroom," Burnett said. "So we have really tried very hard to work with that department and that individual, so we can maybe return them on an alternate assignment to let them finish out and not have any other resources of opportunities."
Texas legislation determines UTD's parental leave policy just like the other schools in the UT System. Director of Employee Benefits Marita Yancey said any deviation from the UT Systems policy is only allowable through law because it is a university funded by Texas and must follow state regulations.
The Committee for the Support of Diversity and Equity has drafted a specific policy within the last year for faculty members' parental leave. Sabharwal said the committee is now sharing the policy with deans and hopes to take it to the president.
"Even though we don't have that policy in place right now, we definitely try to understand the situation and work with the department and the employee," Burnett said. "Our goals are to partner with all these departments and offer the best benefits we can to our employees."
Another concern raised by survey respondents was diversity in faculty ranks. Almost 90 percent of respondents in all demographic categories said that diversity was important to them personally and that it was important to them that UTD hold diversity as one of its core values; 3 percent said diversity is not at all important. According to the climate survey, respondents reported significant structural and institutional barriers that interfere with the successful recruitment, promotion and fair pay of women and racial and ethnic minority employees.
Sabharwal said UTD is doing a much better job than when she began in 2009, however, with more women in leadership roles, more female program heads and greater representation for women in faculty ranks. Her research points to three key factors that alleviate the glass cliff and encourage women to stay: greater involvement in policy-making, a feeling of empowerment and an assurance of organizational justice and equity.
"Tokenism does not work," Sabharwal said. "Diversity goals are not about the number of women in these leadership positions, it's the quality of an inclusive work environment. Are you empowering the women in these leadership roles? Are they able to influence the policy-making, or are they just a number on the table?"
Skaggs said a notion that is often misleading is that just putting women in higher-level positions or leadership positions will create greater opportunities for women across the board; for real change to happen, it is necessary to hold the university to a higher standard.
"You can't just necessarily have diversity training or things like that," Skaggs said. "It's really how people at higher levels are held responsible for creating an overall culture that doesn't tolerate discrimination and allows opportunities across the board regardless of class, gender and ethnicity. We need to be teaching how to identify ways that we are potentially biased or hiring people exactly like ourselves."
Another staff member, who identified himself as neither a female nor a minority, said that diversity must be a priority.
"The central administration — president, provost, VPs, deans, are overwhelmingly male," he said. "At least half of the administrators should be female. Half of the deans, for example, should be female. For the most part, UTD is run by old white males … I have nothing against old white men, being one myself. But we need diversity in administration to match diversity of student population."
Some survey respondents, however, said they disagreed with certain efforts to promote diversity on campus.
"I'll tell you that seeing special clubs, events and holidays for every group except white heterosexuals doesn't make me feel welcomed as part of the community," said an anonymous staff member. "Why should there be special groups at all? Why can't we just go to class and do our work? Why should the university spend money and time on events, activities or groups at all? Meanwhile tuition is increasing every year."
Another faculty person called the survey "politically correct pandering that reflects patronizing social engineering," and 7.4 percent of respondents said UTD places too much emphasis on achieving diversity. However, nearly half of survey respondents said that building a diverse and inclusive campus community should be a key goal of UTD.
Sabharwal said, ultimately, both men and women need to be involved in the conversation. Women and men are a part of UTD's faculty and staff, so any disparity affects both parties.
"Women are not the problem," Sabharwal said. "Women are the solution."
Diversity8 Gender equality4 Parental leave1
Success center adds study spaces
SG Report: 4/23/18


To help bring awareness to World Water Day, we've asked Mercy Corps—one of our Partners for Change—to share with us what access to clean water means. Marginalized groups—women, children, refugees, indigenous peoples, disabled people, and many others—are often overlooked, and sometimes face discrimination as they try to access and manage the safe water they need.
No corner of the world has been untouched by adversity. From Puerto Rico to Venezuela, to Jordan – the challenges have never been greater. Access to clean water still ranks as one of today's greatest challenges. The global community set a Sustainable Development Goal to ensure access to water and sanitation for all by 2030. And yet, worldwide, approximately 1 in 10 (780 million) people still do not have access to safe water, and approximately 1 in 3 (2.5 billion) people lack access to adequate sanitation. Unsafe water, inadequate sanitation, and poor hygiene directly contribute to disease and malnutrition.
The disparities in water access disproportionately affect women and girls who are often expected to 'manage' household water, which includes spending multiple hours each day fetching water from sources at least a mile away. Similarly, the absence of a household toilet has a profound impact on hundreds of millions of women and girls who have to find somewhere private and safe to relieve themselves. Many face abuse and the risk of violence. All face the loss of dignity and respect.
Mercy Corps, a global humanitarian organization and one of Nau's Partners for Change, saves and improves lives and strengthens communities around the world. One way they do that is by working to close the gap in improved water and sanitation access and promote positive health outcomes. Last year alone, they connected more than 3 million people to clean water and improved hygiene and sanitation facilities.
In times of disaster or crisis, Mercy Corps is on the ground providing safe drinking water, appropriate sanitation facilities and promoting key hygiene practices to prevent water-borne disease. In early recovery, they swiftly mobilize resources to repair and establish water and sanitation infrastructure and services with an eye towards durable, long-term solutions.
One example of their work in action can be seen in Jordan, where water scarcity is at critical levels. Jordan's rapidly modernizing society, coupled with an influx of Syrian refugees, has put new demands on its limited supplies and in some northern communities, water demand has quadrupled. Water conservation is critical, but an integrated effort to offer support and services to farmers, households, and communities that encourage and facilitate the adoption of water saving technologies is also urgent as tensions over this increasingly limited resources are likely to rise.
So, in 2017, Mercy Corps started a five-year project that aims to increase water conservation in Jordan by focusing on water efficiency on farms, at households, and in communities. Mercy Corps is working with farmers in the north and the Jordan Valley, and with households and communities in the north that are hosting large numbers of Syrians. The project has already saved thousands of cubic meters of water through the installation of water-saving technologies on an early-adopter farm, through water saving devices in households, as well as grey water systems and one decentralized wastewater system in the project's areas. These interventions are helping to meet water demands today while also supporting communities to prepare for long-term needs down the road.
Mercy Corps' work in Jordan goes far beyond water delivery and conservation. Over the next couple of months, we plan to share more stories about how Mercy Corps is supporting refugees and host communities to build stronger tomorrows. We invite you to follow along!
All photos courtesy of Mercy Corps.


"When we say partnering, we mean listening, understanding and becoming part of our clients' recruitment teams"
Outsource UK supply a wide range of staff to the public Sector, with a dedicated team of recruiters and resourcers using their expertise to find the best candidates for our clients.
And we also offer support on other workforce solutions in Logistics and Supply Chain, Cyber and Financial Services.
For more information, advice and guidance and contingent and permanent staffing, please contact Rebecca Inns on 01793 430 021.
Our specialist recruiters support candidates with comprehensive and highly effective job search and advice services. We're as passionate about your career as you are, so you can depend on us to offer you only appropriate, worthwhile Public Sector jobs and then provide all the backup and guidance you need for a successful application.
Outsource UK will find you the best-qualified and most suitable candidates for your Public Sector job. Based on their in-depth understanding of your needs, our specialist recruiters will be highly selective, so you're not overwhelmed with CVs. You can be sure each candidate we submit is well worth interviewing, whether it's for a permanent, interim or contract role.


D. Barnhisel R. 1990. Juvenile fish response to the cladoceran Bythotrephes cederstroemi. Department of Biology. Master of Science:73pp..
Jr. JTEmlen. 1956. Juvenile mortality in a Ring-billed Gull colony. The Wilson Bulletin. 68:232-238.


text:
Rediff.com » Business » The reality of Indian realty: More downs than ups
The reality of Indian realty: More downs than ups
By Raghavendra Kamath
March 28, 2018 09:02 IST
'Most real estate companies, were listed during the period of irrational exuberance. The sector at the time was at a peak after seeing steady growth over the last seven years. Hence, a correction was inevitable.'
'These companies listed at significant premiums to their future cash flows and net asset values. Analysts were valuing returns even on future cash flows.'
Raghavendra Kamath reports on what ails India's real estate sector.
The collapse of Lehman Brothers and the global financial slowdown made private equity (PE) funds cut investments in the real estate sector, impacting property sales. While PE funds such as Wachovia and Lehman Brothers exited the sector, developers halted their hotel and special economic zone projects that needed large investments.
Developers almost stopped building office projects between 2008 and 2012, focusing instead on the residential market.
The residential sector looked up after 2011, but revival was short-lived. Observers say the sector has seen time correction of 8-10 per cent every year in the past five years, thus, becoming more affordable. The downward interest rate cycles also helped homebuyers.
A broad-based recovery is expected to take a year or two, according to experts.
"The past decade witnessed a gradual change in Indian real estate in terms of assimilation of global best practices into local work ethic. Mechanisation was the big move, towers soared to the skies. Indian real estate moved towards working as a corporate entity, self-regulation and made attempts at becoming transparent," said Niranjan Hiranandani, founder and managing director at Hiranandani Constructions.
The side effect of going global
From making homes, the sector gradually turned into an investment class, in which investors pumped in money based purely on excel sheets and architectural blueprints, he said.
But it was an interesting period for the initial public offering market, as several big-ticket IPOs of DLF, Oberoi Realty and so on hit the market.
The past five years saw global PE majors making big acquisitions in office and mall space. Blackstone invested more than $3 billion in buying information technology parks and building a portfolio of 70 million sq ft with its partners.
It has formed joint ventures with the Embassy group of Bengaluru and Panchshil of Pune. It also picked up a 20 per cent stake in K Raheja Corp of Mumbai.
The company also set up a separate company for malls and owns retail malls to the tune of over 5 million sq ft of retail space.
Other big funds such as Brookfield, GIC and CPPIB signed big deals in the commercial space. GIC signed a $1.4-billion deal with DLF to buy 40 per cent of the promoters stake in DLF's rental arm.
GIC bought 40 per cent in the rental arm of Prestige group for around $300 million.
Last year, the sector went into a tailspin with demonetisation, Real Estate (Regulation and Development) Act (RERA) and the goods and services tax (GST) affecting the sector. Demonetisation affected markets, such as National Capital Region, were cash transactions used to form a major portion of sales.
RERA and GST increased the compliance costs for developers, though these are considered customer-friendly.
Residential launches dropped 50 per cent in 2017, as developers focused on making their projects RERA-compliant. Many small developers went in for joint ventures with bigger ones or sold their projects to tide over the crisis.
Both developers and investors have started focusing on affordable housing in the past couple of months due to regulations supporting it and rising demand.
HDFC Capital, an arm of Housing Development Finance Corporation, tied up with the Prestige group to invest Rs 25 billion in affordable housing.
HDFC Capital floated a similar platform with Mahindra Lifespaces. HDFC Capital has readied a war chest of $1 billion to invest in the segment.
Mumbai-based Shapoorji Pallonji is also investing aggressively in the segment.
The government has come out with lower GST rates and a credit-linked subsidy scheme to promote affordable housing. From the market capitalisation perspective, real estate was among the worst performing sectors in the past 10 years.
"Most real estate companies, were listed during the period of irrational exuberance. The sector at the time was at a peak after seeing steady growth over the last seven years. Hence, a correction was inevitable. These companies listed at significant premiums to their future cash flows and net asset values. Analysts were valuing returns even on future cash flows," said Abhimanyu Sofat, head of research, IIFL.
Sofat says there is one clear silver lining on the horizon, which is commercial real estate.
"Absorption rates in the office segment are likely to go up as we go through a cyclical upturn in the economy, leading to significant value creation. New structures like REITs (real estate investment trusts) will bring further liquidity to this space."
REITs are pooled investments like mutual funds that can be traded on stock exchanges.
Many PE firms are floating funds to invest in commercial real estate as residential developers are struggling to sell properties. Shapoorji Pallonji has tied up with Allianz of Germany to invest in office projects, while Godrej Fund Management entered the segment recently.
Vacancies in office markets such as Bengaluru and Mumbai have hit their lowest levels and absorption levels have remained steady in the past couple of years.
While REITs are the most-watched instruments, the first such issue is at least six months away as Blackstone-Embassy is yet to file its draft red herring prospectus.
Illustration: Dominic Xavier/Rediff.com.
Understanding finance doesn't come naturally to you?
Don't worry. Get smarter with Personal Finance tips delivered to your Inbox.
Raghavendra Kamath
Related News: Lehman Brothers, Raghavendra Kamath, India, Wachovia
Is a bubble building up in IT midcaps?
Why markets are headed for worst 2-month drop since FY16


text:
MSC's Long Beach Terminal Hosts White House Envoy for Tour of Container Dispersal Measures
Total Terminals International (TTI) Long Beach Terminal, hosted a tour by the Port Envoy to the Biden-Harris Administration Supply Chain Disruptions Task Force John D. Porcari on 16 November.
Joined by International Longshore and Warehouse Union (ILWU), International President Willie Adams, port leadership, local legislators and elected officials, Port Envoy Porcari visited the terminal to assess the ongoing work to address the global supply chain crisis and highlight policies to help ease congestion and alleviate backlogs.
The following day, 17 November, TTI Long Beach was once again selected to host California Governor Gavin Newsom's press event, given the terminal's willingness to support the 24-hour port opening promoted by the Biden-Harris Administration in October. In fact, TTI Long Beach Terminal was the first terminal in the Los Angeles-Long Beach area to operate all through the night, back in September.
The Governor thanked the collective work of California and its partners for the swift action taken across the board to address congestion and increase capacity to move goods quickly, stressing the cooperation of both the public and private sectors – from the Federal government, to the ports, the workforce, the retailers, and the shipping lines – for the additional commitments made to tackle the backlog.
The two California ports form the main gateway for goods into the U.S. economy and have been heavily congested during the global supply chain crunch, due to a combination of record volumes, full warehouses, and shortage in chassis and truck availability.
The congestion issues throughout the supply chain have cascaded down into longer waiting times for vessels arriving in the San Pedro Bay before they can be handled, creating significant inefficiencies, and destroying some of the extra vessel capacity that carriers have deployed to support the volume surge.
In response to the supply chain crisis, MSC has increased its ocean fleet capacity by 22% since Q3 2019, as well as adding 11 new mainline trade services and expanding its rail offering in some parts of the world.
MSC's direct investments through TiL (Terminal Investment Ltd) in port infrastructure have helped to develop the required handling capacity and to allow an active intervention in times of crisis. There has also been proactive work with the port community on initiatives to reduce the dwell time of containers, introducing flexible night gates, buying extra terminal handling equipment to reduce the truck turnaround time, and working with other marine terminal operators to amend PierPass to a system that incentivizes truck traffic in off-peak windows.
TiL is one of the world's most geographically diverse container terminal investor-operators and the third biggest container terminal operator in the U.S., with an investment portfolio across five continents. TTI is 80% owned by TiL, which is in turn majority-owned by MSC.
MSC to Take Part in Trans-Port 2021
Andre Simha, MSC's CDIO, will be virtually taking to the stage to discuss the importance of digitalisation and interoperability for the supply chain industry.
Read more on MSC to Take Part in Trans-Port 2021
MSC Estará Presente en la XVIII Convención Internacional del Banano 2021 en Guayaquil
Ven a conocer a nuestros expertos en banano en el stand 22, Salon Isabella I y III, hotel Hilton
Read more on MSC Estará Presente en la XVIII Convención Internacional del Banano 2021 en Guayaquil
MSC Returns to Expoalimentaria 2021
Meet our reefer experts virtually at this virtual event from 30 September to 8 October
Read more on MSC Returns to Expoalimentaria 2021
Email: ECU-info@msc.com
Mediterranean Shipping Company del Ecuador C.A. (EMESSEA), Centrum Building - 15th Floor, Suite 2, Ave Francisco De Orellana Y Alberto Borges, P.O. BOX 10336, EC - GUAYAQUIL, GUAYAS as agent only for MSC Mediterranean Shipping Company SA


text:
Five Rivers Publishing
And the Angels Sang
From Mountains of Ice
Memories, Mother and a Christmas Addiction
The Rose Guardian
Shadow Song
Stonehouse Cooks
Attention Canadian book clubs!
There is what looks like a useful and interesting new portal which connects Canadian authors with book clubs across Canada: The Authors Book Club. Founded by writers David Albertyn and Ann Y.J. Choi, The Authors Book Club aims, in its own words, "to create an online community for authors and readers and to promote engagement between them". The Club also hopes "to be a resource for book clubs in Canada and to connect them with authors". Worthy goals…
By Lorina StephensNewsletterLeave a comment
Thoughts on submissions
I used to think of myself as a dream-maker, someone who would champion unknown Canadian authors and give them voice. In some ways I still hold that belief, live by it. But I've also come to understand an inherent laziness in so many fellow writers, indeed creators. "Laziness?" you cry. Yes. Laziness. What do I mean by that? How could I dare be so cruel? (insert shrug here) It's not with a cavalier attitude or…
By Lorina StephenssubmissionsLeave a comment
What has been, and what is yet to come
Reflections on 2019 It has been an eventful year at Five Rivers. We published the last two novels by Dave Duncan, Pillar of Darkness, and the final novel in the King's Blades series, The Ethical Swordsman. We also released in audiobook the first in that series, The Gilded Chain, skillfully narrated and produced by Austin Vanfleet. It was bittersweet, but also hopeful because Dave's work lives on. In an irony that follows so many individuals involved in the arts, Dave's…
So you want to submit to Five Rivers
Read the Guidelines! So you think you'll try your luck with Five Rivers this year. The first imperative: READ THE GUIDELINES! Yes, I know that was all in caps. It's in caps because I'm hoping you'll actually pay attention to those guidelines. You have no idea how many submissions cross my desk, briefly, which demonstrate clearly the author hasn't bothered to check out Five Rivers' guidelines. Or if they have, think their work is so…
What's happening at Five Rivers in 2019
It's been 11 years since first I launched Five Rivers Publishing. I've been proud to publish over 70 books in that time, by some 30 authors. That catalogue has ranged from science fiction and fantasy, historical and mainstream fiction, detective and horror, and non-fiction covering everything from how to write effectively, historical and modern cookery, and investigative research into wrongful convictions. A Common Thread What has been common through all these publications is the championing…
Writers' Craft 12: Agent, publisher or indie? January 6, 2021
Writers' Craft 11: Beta Readers or Not January 3, 2021
Writers' Craft 10: Revision December 29, 2020
Writers' Craft 9: Research December 8, 2020
Writers' Craft 8: World Building November 29, 2020


Beat the egg yolks and water in a small bowl with a fork.
Sprinkle the flour on the work surface. Unfold 1 pastry sheet on the work surface. Roll the pastry into a 16-inch square. Brush the pastry with the egg mixture. Cut the pastry sheet into 16 (4-inch) squares. Repeat with the remaining pastry sheet.
Place 1 teaspoon chocolate pieces and 1 raspberry in the center of each pastry square. Fold the pastry over the filling to form a triangle. Crimp the edges with a fork to seal. Prick the tops of the pastries with a fork. Brush the pastries with the egg mixture. Place the pastries onto 3 baking sheets. Freeze for 15 minutes or until firm.
Bake for 15 minutes or until the pastries are golden brown. Sprinkle with the confectioners' sugar.


text:
Sangamo BioSciences announces presentation of clinical Data Demonstrating Functional Control of Viremia in HIV-Infected Subjects treated with SB-728-T
RICHMOND, Calif., Sept. 12, 2013 /PRNewswire/ -- Sangamo BioSciences, Inc. (Nasdaq: SGMO) announced today the presentation of new data from its ongoing Phase 2 clinical trial (SB-728-902 Cohort 5) to evaluate a single infusion of Sangamo's novel ZFP Therapeutic®, SB-728-T, for the treatment of HIV/AIDS. The data demonstrate functional control of the virus at or below the limit of detection in CCR5 delta-32 heterozygote HIV-infected subjects treated with SB-728-T. The abstract was selected as a "late-breaker" presentation at the 53RD Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). On Wednesday, September 11, data were also presented demonstrating depletion of the HIV viral reservoir in SB-728-T treated subjects in cohorts 1-3 of the SB-728-902 study.
Data from the late-breaking presentation demonstrate that viral load (VL) became undetectable during a treatment interruption (TI) from antiretroviral therapy (ART) in three of seven evaluable CCR5 delta-32 heterozygote HIV-infected subjects, including two of six subjects that had completed TI in the ongoing SB-728-902 Cohort 5 study and an additional subject from an earlier Phase 1 clinical trial of SB-728-T. In one SB-728-902 Cohort 5 subject, VL has remained undetectable (at or below the limits of quantification (LOQ) of the current ultra-sensitive assays for HIV) for seven weeks (to last measurement taken) and the TI is ongoing. Reduction in VL from peak during TI showed a statistically significant correlation (p=0.015) with estimated numbers of engrafted ZFN modified cells (SB-728-T) in which both copies of the CCR5 gene had been disrupted (biallelic modification), in line with previously presented data from this program.
"The data presented today demonstrate that a single infusion of SB-728-T can lead to profound suppression of viral load in the blood and sustained functional control of the virus," stated Dale Ando, M.D., Sangamo's vice president of therapeutic development and chief medical officer. "This is the first evidence that sustained functional control of HIV in the absence of ART is possible. The fact that three of the seven evaluable CCR5 delta-32 subjects achieved undetectable levels is a major step toward immunological functional control of HIV. We look forward to following these Cohort 5 subjects and presenting a complete data set from this study by the end of the year."
In a presentation on September 11, 2013 entitled "Host Immune Environment Significantly Impact the Level of CD4 Reconstitution and the Effects on Latent Reservoir in HIV Subjects Receiving ZFN CCR5 Modified CD4 T-cells (SB-728-T)," data were presented that demonstrated that treatment of HIV infected subjects with SB-728-T leads to a long term increase in CD4 counts. The effect on total CD4 counts in SB-728-T-treated subjects was significantly greater than those observed in previously published T-cell infusion studies without CCR5 modification and correlated with increased CD4 central memory and increased CCR5-disrupted central memory cells. In addition, a median 0.6 log reduction decrease in the size of the HIV reservoir at twelve months was observed, as demonstrated by measurement of HIV total DNA in peripheral blood mononuclear cells (PBMCs). The decrease in reservoir showed a statistically significant correlation with the improvement in CD4 count. Finally, data were presented describing possible predictors of robust CD4 T-cell reconstitution and immunological response post SB-728-T infusion.
"These data are extremely important and suggest that an immunological approach to control of HIV infection is obtainable," commented Rafick-Pierre Sekaly, Ph.D., Co-Director & Chief Scientific Officer of the Vaccine & Gene Therapy Institute of Florida(VGTI Florida), and a collaborator on the study. "SB-728-T treatment results in an unprecedented and durable increase in CD4+ cells primarily due to the expansion of central memory cells - CD4+ T-cell types that are vital for the successful reconstitution of the immune system in HIV-infected individuals. This enables functional control of virus and effects on the latent reservoir of HIV-infected cells that cannot be cleared by ART."
Central and transitional memory T-cells remember previously encountered foreign invaders, such as viruses or bacteria. These cells can survive in the body for the individual's lifetime and reactivate when they re-encounter the same antigen. On reactivation they produce a faster and stronger immune response than the previous encounter. SB-728-T seems to both expand the total memory pool and, by CCR5 modification, protect a proportion of that pool from HIV entry, suggesting that SB-728-T treatment has the potential to durably reconstitute and protect an effective immune system in HIV-infected individuals.
"We are amassing a body of data suggesting that SB-728-T treatment can potentially enable attacks on HIV infection from several angles," said Geoff Nichol, M.B., Ch.B., Sangamo's executive vice president of research and development. "Our aim is to provide a protected reservoir of immune memory cells to replenish the cells killed by HIV and to generate an effective immune response against the virus and opportunistic infections. Some HIV-infected individuals, so-called 'elite controllers,' can accomplish this without drug intervention. These individuals typically have low CCR5 expression and good anti-viral CD8 responses, a characteristic shared by those SB-728-T treated subjects in which we have to date seen the greatest effects on the virus. We have demonstrated that SB-728-T treatment results in a durable increase in total CD4 T-cells and, in these presentations, an effect on controlling the acute rebound in viral load off ART, and a longer term effect on the viral reservoir, a source of HIV which is not addressed by current anti-retroviral therapies. The data will be used to optimize the development of this therapy as a functional cure for HIV."
Dr. Nichol added, "In addition to our SB-728-902 Cohort 5 study, we have a second ongoing trial (SB-1101) designed to maximize the engraftment of SB-728-T in subjects who are not CCR5 delta-32 heterozygotes and who represent the vast majority of HIV-infected individuals. Maximizing circulating SB-728-T is important, as viral control appears related to the extent of engraftment. This trial is evaluating escalating doses of a preconditioning drug, cyclophosphamide (Cytoxan®), which is used to transiently reduce the numbers of T-cells in the body. The cells rapidly repopulate once the drug is discontinued, an effect that can enhance engraftment of concurrently administered exogenous T-cells such as SB-728-T. We intend to present data from all dose-escalation cohorts in these studies before the end of 2013."
About SB-728-T
Sangamo's drug, SB-728-T, is generated by ZFN-mediated modification of the gene encoding the CCR5 receptor in a patient's own T-cells. ZFN modification disrupts the expression of this key co-receptor for HIV entry and renders cells resistant to HIV infection. The approach is based on the observation that a naturally occurring mutation in the CCR5 gene, CCR5 delta-32, provides protection from HIV infection. Individuals in whom both copies of the CCR5 gene carry the delta-32 mutation are generally not susceptible to the most common strain of HIV.
Summary of Clinical Trial Design
About SB-728-902 Cohorts 1-3
The study is an open-label Phase 1 clinical trial to evaluate the safety and tolerability of single infusions of an escalating dose of an autologous (a patient's own) CD4+ T-cell product genetically modified at the CCR5 gene by CCR5-specific ZFNs (SB-728-T). The trial enrolled nine HIV-infected subjects (three cohorts of three subjects each) who have sub-optimal T-cell levels and no detectable viral load on long-term ART. Subjects remained on their existing antiviral therapy while receiving treatment with SB-728-T.
About SB-728-902 Cohort 5
Up to 20 HIV-infected subjects heterozygous for the CCR5 delta-32 mutation (i.e. with one CCR5 gene that is naturally modified) who are currently on ART are being enrolled and will receive a single intravenous infusion of SB-728-T (5 to 30 billion modified cells). Two months after SB-728-T treatment, subjects undergo a 16 week TI during which time their ART is discontinued. ART will be reinstituted in subjects whose CD4 T-cell counts drop to < 350 cells/ mm3 and/or whose HIV-RNA increases to > 100,000 /mL for three consecutive weekly measurements. At the end of the TI, subjects with a sustained detectable HIV viral load are reinstituted on ART. Subjects with an undetectable viral load can remain off ART until HIV RNA levels are detectable or their CD4 T-cell count drops below 350 cell/mm3 for three consecutive weekly measurements.
A total of ten subjects have been treated in this cohort.
Of the six evaluable subjects, we observed two subjects in which their VL became undetectable during TI from ART:
In one subject, VL suppression at, or below, the limit of quantification (LOQ) of virus was sustained from week 11 — 19 of TI and the TI is ongoing.
In the second subject there was a transient suppression of VL at or below LOQ. The subject remains off ART.
A third subject completed the TI with 1-log decrease in VL from peak.
In three subjects, there was no reduction in VL during the TI, one completed the TI and in two the TI was terminated early due to their viral loads exceeding the upper limit allowed in the protocol.
A seventh subject has not completed TI and is still being evaluated.
The non-employee authors of these abstracts have no financial relationship with Sangamo.
About Sangamo
Sangamo BioSciences, Inc. is focused on research and development of novel DNA-binding proteins for therapeutic gene regulation and genome editing. The Company has ongoing Phase 2 and Phase 1/2 clinical trials to evaluate the safety and efficacy of a novel ZFP Therapeutic® for the treatment of HIV/AIDS. Sangamo's other therapeutic programs are focused on monogenic diseases, including hemophilia and hemoglobinopathies such as sickle cell anemia and beta-thalassemia, and a program in Huntington's disease. Sangamo's core competencies enable the engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). Engineering of ZFPs that recognize a specific DNA sequence enables the creation of sequence-specific ZFP Nucleases (ZFNs) for gene modification and ZFP transcription factors (ZFP TFs) that can control gene expression and, consequently, cell function. Sangamo has entered into a strategic collaboration with Shire AG to develop therapeutics for hemophilia, Huntington's disease and other monogenic diseases, and it has also established strategic partnerships with companies in non-therapeutic applications of its technology including Dow AgroSciences and Sigma-Aldrich Corporation. For more information about Sangamo, visit the company's website at www.sangamo.com.
ZFP Therapeutic® is a registered trademark of Sangamo BioSciences, Inc.
This press release may contain forward-looking statements based on Sangamo's current expectations. These forward-looking statements include, without limitation, references relating to research and development of novel ZFP TFs and ZFNs and therapeutic applications of Sangamo's ZFP technology platform for the treatment of HIV/AIDS, including a potential functional cure for HIV/AIDS, the ability of a ZFP Therapeutic to control HIV infection, projected timing of release of SB-728-T clinical data, the expansion of clinical studies for HIV-infected individuals and the initiation of additional preclinical studies of ZFN-gene modification. Actual results may differ materially from these forward-looking statements due to a number of factors, including uncertainties relating to the initiation and completion of stages of our clinical trials, whether the clinical trials will validate and support the tolerability and efficacy of ZFNs, technological challenges, Sangamo's ability to develop commercially viable products and technological developments by our competitors. For a more detailed discussion of these and other risks, please see Sangamo's public filings with the Securities and Exchange Commission, including the risk factors described in its Annual Report on Form 10-K and its most recent Quarterly Report on Form 10-Q. Sangamo assumes no obligation to update the forward-looking information contained in this press release.
SOURCE Sangamo BioSciences, Inc.


This light requires the use of either a rubber grommet or Maxxima brand mounting flange. This light has a built-in three-prong female plug in the back.
This light is RED when on.
Converting all your incandescent lights to LED? You may want to read about LED flashers.