text:
VIDEO: Will The New Superman Movie Succeed Where All Others Have Failed?
Story from Entertainment
Leila Brillson
It is impossible to make Superman cool. Yes, he is one of the most iconic superheroes of all time, but he's stuck as the gallant straight man to Batman's Dark (and brooding) Knight. In fact, one of the things that makes the superhero mythos so interesting is that all superheroes are flawed and must suffer in order to gain their powers — Batman watches his parents die, Green Lantern has a life-ruining ring, and the freakin' Swamp Thing is a genetically mutated bog creature. (That's just DC; Marvel's lineup includes entire families being murdered and attacks by radioactive spiders as power origins.) But Superman is just born*. Which doesn't give him the drama and relatability of, say, Bruce Wayne. (Not to mention the fact that you can majorly revamp the Batmobile to be the Tumbler...but those wrestling boots? Not much hope for them.)
Yet, here is Zack Snyder, auteur behind other comic book classics such as 300 and The Watchman, taking a page from the book of Terrence Malick and rebooting, for the fourth time in two decades, Superman. The very attractive Henry Cavill plays this iteration of Clark Kent, the Smallville-by-way-of-Krypton resident who is just trying to figure out why and how he can fly, set against a stark midwest backdrop.
The difference between this and past Superman interpretations are both good and bad: It's good that Christopher Nolan is producing, because no one knows a reboot quite like the man behind The Dark Knight. It's bad because, after Sucker Punch and Watchmen, Zack Snyder has proven he has a lot of style...and not much else. (Though, his Dawn Of The Dead is fantastic.) As for Cavill himself, it may be a little blasphemous to have the man representing, "truth, justice, and the American Way" be, you know, British.
Check out the trailer below and watch Snyder revel in the "man" in Man Of Steel...a 'man', we have to note, who doesn't actually exist.
*He does survive the destruction of his entire planet and species, but he doesn't know about that until later.
Man Of Steel Trailer - New Superman Movie
Entertainment • Movie Trailers • Movies
written by Leila Brillson
It's Time For Black TikTok Creators To Be Paid Their Worth
Forbes recently named TikTok's top-earning creators, including Charlie and Dixie D'Amelio and Addison Rae.
How Sita Abellan Is Rethinking The Word "Influencer" For Hispanic...
Sita Abellan epitomizes "Jack of all trades." Throughout the course of the last decade, she's worked as a model, a designer, an Instagram Personality
Book-ish
Books By Black Authors We Can't Wait To Read In 2022
by Stephanie Long
Would You Survive A Scream Movie? Here Are Your Odds, Ba...
January is a time for beginnings: A whole new year stretches ahead, entirely unmarred. We're all feeling rested, sated, bolstered by family time and extr
by Robert Hickerson
Cheer Season 2 Shows The Dirt Underneath The Pyramid
Minor spoilers ahead. It only takes about five minutes into the season 2 premiere of Netflix's Cheer to realize that this is going to be a very different
by Katherine Singh


Items available for bidding on the introductory Online Auction from 2/14/18 through 2/19/18.
Men's Black 3G Beach Cruiser with 36 inch wheels.
Family Admission Pass, good for one-time general admission for 2 adults and 2 children (ages 3-12). Any children 2 or younger gain free admission.
Mrs. Palazzolo is offering a lucky 1st, 2nd, 3rd OR 4th grader a spot on stage with the 5th through 8th grade childrens ensemble in this year's Spring musical "Oliver!"
Your child will learn the simple choreography and song lyrics so they can experience the thrill and excitement of being in a large production. Costumes are very simple for this production and we have many bins of costume pieces to choose from. There will be very limited rehearsal time in late February and early March 2018.
Mrs. Palazzolo is offer a lucky 1st, 2nd, 3rd OR 4th grader a spot on stage with the 5th through 8th grade children's ensemble in this year's Spring musical "Oliver!"
You will be the best parent in the class when you bid for your child to be The Teacher's Assistant For A Day! Help with paperwork, lessons, and sit in the teacher's chair! What a great experience for any child!


text:
Q: Using many typewriter fonts in a single document Reading topics about monospaced fonts, I found out that changing \tt font for the document requires replacing only one line in the preambule. For example, I only change the commented line
\documentclass[a4paper,11pt]{article}
\usepackage[T1]{fontenc}
\usepackage[utf8]{inputenc}
% PLACE NEW FONT
\begin{document}
Default
\input{test.tex}
\end{document}

to \renewcommand

*

*\renewcommand{\ttdefault}{cmtt} for Computer Modern Typewriter

*\renewcommand{\ttdefault}{cmvtt} for Computer Modern Typewriter Proportional

*\renewcommand{\ttdefault}{lcmtt} for Computer Modern Teletype L

*\renewcommand*\ttdefault{lmvtt} for Latin Modern Typewriter Proportional

*\renewcommand{\ttdefault}{pcr} for Courier

*\renewcommand*\ttdefault{txtt} for TXTT
or \usepackage

*

*\usepackage[ttdefault=true]{AnonymousPro} for Anonymous Pro

*\usepackage{ascii} for Ascii

*\usepackage[scaled=0.82]{beramono} for Bera Mono

*\usepackage{courier} for Courier

*\usepackage[scaled=1.04]{couriers} for Scaled Courier

*\usepackage{DejaVuSansMono} for DejaVu Sans Mono

*\usepackage[defaultmono]{droidmono} for Droid Sans Mono

*\usepackage{inconsolata} for Inconsolata

*\usepackage{kpfonts} for KP Monospaced

*\usepackage{lmodern} for Latin Modern

*\usepackage[zerostyle=d]{newtxtt} for New TXTT

*\usepackage[ocr-a]{ocr} for OCR-A Optical Character Recognition Font A

*\usepackage{ocr} for OCR-B Optical Character Recognition Font B

*\usepackage{pxfonts} for PX Fonts

*\usepackage{tgcursor} for TeX Gyre Cursor

*\usepackage[scaled=1.05,proportional,lightcondensed]{zlmtt} for Latin Modern Typewriter Z

*\usepackage{luximono} for LuxiMono (needed getnonfreefonts luximono)

*\usepackage[scaled=1.05]{ulgothic} for Letter Gothic (needed getnonfreefonts lettergothic)

In the test.tex I simply use {\ttfamily ... } and I get selected font instead of default \tt.
What should I do to use the all listed above fonts in the same document?
The idea is something like this
\begin{document}
Default
\input{test.tex}
% Switch to AnonymousPro
\input{test.tex}
% Switch to ...
\end{document}

A: David Carlisle's answer is about changing current font. The answer from cfr changes \ttdefault.
I cannot call my solution complete because I couldn't make it for all the fonts. Looking for font families names took me some time. So I put them in my own answer.
\documentclass[a4paper,11pt]{article}
\usepackage[T1]{fontenc}
\usepackage[utf8]{inputenc}
% Store the default font
\edef\oldtt{\ttdefault}
% Fonts from packages
\usepackage{ascii}
\usepackage[scale=1.05,ttdefault=true]{AnonymousPro}
\usepackage[scaled=0.84]{beramono}
\usepackage[scaled=1.04]{couriers}
\usepackage[scaled=0.9]{DejaVuSansMono}
\usepackage[defaultmono]{droidmono}
\usepackage[scaled=0.95]{inconsolata}
   %\usepackage{kpfonts}
   % ! LaTeX Error: Option clash for package textcomp.
   %\ifkp@text\ifkp@textcomp\RequirePackage[full]{textcomp}\fi\fi
\usepackage[nomath,notext]{kpfonts}
\usepackage{lmodern}
\usepackage[scaled=0.84]{luximono} % getnonfreefonts luximono
\usepackage[zerostyle=d,scaled=0.96]{newtxtt}
   %\usepackage{ocr}
\usepackage[scaled=.93]{newtxtext}
   %\usepackage{pxfonts}
   %\usepackage{txfonts}
\usepackage{tgcursor}
\usepackage[scaled=0.92]{ulgothic} %  getnonfreefonts lettergothic
\usepackage[scaled=1.20,proportional,lightcondensed]{zlmtt}

\addtolength{\voffset}{-1.5cm}
\addtolength{\hoffset}{-2.0cm}
\addtolength{\textheight}{3.0cm}
\addtolength{\textwidth}{4.0cm}

\begin{document}
% The last one
\ttdefault\\ % why do I get zlmvtt?
\input{testtt}

% Back to default
\renewcommand{\ttdefault}{\oldtt}
Default\\
\input{testtt}

pcr\\
{\renewcommand{\ttdefault}{pcr} \input{testtt}}

cmtt\\
{\renewcommand{\ttdefault}{cmtt} \noindent\input{testtt}}

cmvtt\\
{\renewcommand{\ttdefault}{cmvtt} \noindent\input{testtt}}

lcmtt\\
{\renewcommand{\ttdefault}{lcmtt} \noindent\input{testtt}}

lmvtt\\
{\renewcommand{\ttdefault}{lmvtt} \noindent\input{testtt}}

txtt\\
{\renewcommand{\ttdefault}{txtt} \noindent\input{testtt}}

AnonymousPro\\
{\renewcommand{\ttdefault}{AnonymousPro} \noindent\input{testtt}}

Beramono\\
{\renewcommand{\ttdefault}{fvm} \noindent\input{testtt}} % Beramono

% Courier == pcr

Scaled Courier\\
{\renewcommand{\ttdefault}{pcrs} \noindent\input{testtt}} % Scaled Courier

DejaVuSansMono\\
{\renewcommand{\ttdefault}{DejaVuSansMono-TLF} \noindent\input{testtt}}

Droid Mono\\
{\renewcommand{\ttdefault}{fdm} \noindent\input{testtt}} % Droid Mono

Inconsolata\\
{\renewcommand{\ttdefault}{zi4} \noindent\input{testtt}} % inconsolata

KP tt\\
{\renewcommand{\ttdefault}{jkptt} \noindent\input{testtt}} % KP tt

Latin Modern\\
{\renewcommand{\ttdefault}{lmtt} \noindent\input{testtt}} % latin modern

LuxiMono\\
{\renewcommand{\ttdefault}{ul9} \noindent\input{testtt}} % LuxiMono

New TXTT\\
{\renewcommand{\ttdefault}{newtxtt} \noindent\input{testtt}} % New TXTT

% Optical Character Recognition Font B ?

% PX Font tt == TX Fonts == txtt ?

New TX\\
{\renewcommand{\ttdefault}{ntxtt} \noindent\input{testtt}} % New TX

qcr\\
{\renewcommand{\ttdefault}{qcr} \noindent\input{testtt}} % gyre cursor looks like courier ?

Letter Gothic\\
{\renewcommand{\ttdefault}{ulg} \noindent\input{testtt}} % Letter Gothic

zlmtt\\
{\renewcommand{\ttdefault}{zlmtt} \noindent\input{testtt}} % Latin Modern Typewriter Z

ascii\\
{\asciifamily \noindent\input{test}} % No file T1ascii.fd

\end{document}

Fo the testtt.tex file (File test.tex for ascii is without {\ttfamily ... })
{\ttfamily
Normal {\bfseries Bold}
{\slshape Slanted} {\bfseries\slshape Slanted\&Bold}
{\itshape Italic} {\bfseries\itshape Italic\&Bold}
Z2 lI1 S5 O0}

I get the following font comparison (attention, some fonts are scaled!).

A: If you want to run a test document which includes the typewriter font alongside other styles (e.g. to test how well a particular typewriter font works with a serif used for body text) or you just don't like typing, this example provides a couple of commands for convenience:
\documentclass[a4paper,11pt]{article}
\usepackage[T1]{fontenc}
\usepackage[utf8]{inputenc}

\newcommand*\ttfontstotry{cmtt,cmvtt,lcmtt,lmvtt,pcr,txtt}% add additional families here, separated by commas
\makeatletter
  \newcommand*\myttfontstest{% defines the actual test command
    \@for \xx:=\ttfontstotry \do {% loops through the families
      \par family: \xx\par
      \renewcommand*\ttdefault{\xx}%
      \input{test}%
    }%
  }
\makeatother

\begin{filecontents}{test.tex}% just for testing
    ABCDEFGHIJKLMNOPQRSTUVWXYZ

    abcdefghijklmnopqrstuvwxyz

    Oh, jinxed quartz of black sphinx, go hear my vow!

    {\ttfamily
      ABCDEFGHIJKLMNOPQRSTUVWXYZ

      abcdefghijklmnopqrstuvwxyz

      Oh, jinxed quartz of black sphinx, go hear my vow!}

\end{filecontents}

\begin{document}

  \myttfontstest% try them out!

\end{document}

A:
You can just use the font family without making it the default. For the packages you need to check their documentation the name of the font family used, then use it in the same way.
\documentclass{article}
\usepackage[T1]{fontenc}

\begin{document}

{\fontfamily{cmtt}\selectfont abcdef 123}

{\fontfamily{cmvtt}\selectfont abcdef 123}

{\fontfamily{lcmtt}\selectfont abcdef 123}

{\fontfamily{lmvtt}\selectfont abcdef 123}

{\fontfamily{pcr}\selectfont abcdef 123}

{\fontfamily{txtt}\selectfont abcdef 123}

\end{document}

redpajama_set_name: RedPajamaStackExchange


PLUTO IT Engineering and Multimedia Institute is an Authorized Training Center of C-DAC GIST PACE which is approved and certified by A Scientific Society of Ministry of Information Technology, Govt. of India.organizations.
Pluto IT Engineering & Multimedia Institutes provides high quality training in Graphic Design, Web Design, Web Development, Full time multimedia and animation, Video Editing, SEO and Digital Media Marketing. Pluto IT Engineering & Multimedia Institutes is also into developing, our designing team works dedicated in building web base and responsive websites.
We are committed to delivering the latest know-how and the advanced techniques to our students. Pluto IT Engineering & Multimedia Institutes offers a wide range of technical courses to the mass of students, who are of average or below average merit and they are gifted with a career after successful completion of their respective courses.
Students At Pluto IT Engineering & Multimedia Institutes are very momentous. They are like our institute's pride.
Our institute provides a placement facilities. Student will get all kind of training to for pre- placement interviews at Pluto IT Engineering & Multimedia Institutes.
Pluto IT Engineering & Multimedia Institutes has supported every student here. So if you have one of them then you have every right to feel happy as alumnus of this institute. Pluto IT Engineering & Multimedia Institutes keeps evolving with Time. Connect with your alma mater. Come Home to PITMMI !


There are many pocketsize digital music players available, but they fall into two groups: Apple's iPod products and everything else. That split, rooted in technology as well as style, poses a challenge for music lovers who want to upgrade their devices.
IPods, the most popular music players with more than 70 percent of the American market, can play MP3 music files, a popular digital audio compression format. But for the most part, Apple steers its customers to songs in another format, called Advanced Audio Codec (AAC), which most non-Apple devices cannot play.
Apple's iTunes software, which runs on PC's and Macs, for example, automatically "rips," or converts, music from CD's into compressed AAC files for loading onto a computer or portable player. But users who want to convert tracks to MP3 files have to change the settings.
And downloads from Apple's iTunes Music Store come exclusively in a version of AAC that includes FairPlay, Apple's digital rights management technology, to prevent illegal copying and sharing of music. "One of the problems I see a lot is that people who are using iTunes-iPods have ripped their entire CD collection to the AAC format because that is the default setting in iTunes," said Grahm Skee, who runs the Web site AnythingButiPod.com, in an e-mail interview. "Now they are stuck with a format that can only be played on iPods."
At the same time, most of Apple's rivals use Microsoft's Windows Media Audio (WMA) format, which does not play on iPods. And most online music stores apart from iTunes -- like Napster (napster.com), Wal-Mart (musicdownloads.walmart.com) and Yahoo Music (music.yahoo.com) -- sell downloads in the copy-protected Secure WMA file format.
With many people's digital music collections locked into one of two incompatible formats, their choices for new music players are largely determined by what they bought in the past. Those who want to remain neutral in the format wars -- or who want to switch sides -- may spend more and endure inconveniences.
So why not avoid all that trouble and just go with Apple? After all, its music players are trendsetters, and the iTunes music store offers a large collection of titles.
But the iPod's list of missing features is also noteworthy. No iPod offers a built-in FM radio, for example, or a voice recorder. These features are common on rival players from companies like Archos, Cowon Systems, Creative, iRiver and Samsung. And Apple has yet to release a device with video playback abilities like those on Creative's Zen Vision hand-held device.
Nor does iTunes offer a streaming service that lets subscribers listen to any song in its catalog for a monthly fee. Subscription sites like Napster, Rhapsody (rhapsody.com) and Yahoo Music have extended this offering by using a Microsoft technology that lets customers load tracks onto new WMA-based players and listen to them as long as their subscriptions remain current.
The bottom line is that no single music player offers everything, and no one can say what next year's models will provide. To keep their options open, some users spend extra time managing the format of their collections.
A few online music stores try to bridge the Apple-Microsoft gap, though none offer a perfect solution.
People whose tastes stray beyond the top 40 may have luck with eMusic (www.emusic.com), which offers a large collection in the universally playable MP3 format. Many of eMusic's current top artists -- Iron and Wine, Bloc Party and Devendra Banhart -- are not household names like Kanye West and Coldplay, but they are popular among indie rock fans, who purchase more than 2.5 million songs a month, according to the company. EMusic is a subscription-based service, and its offerings start at $9.99 for 40 downloads a month.
Music fans can find a more mainstream selection, although less flexibility, with Rhapsody. Long a popular streaming service, Rhapsody began earlier this year to offer music files for outright purchase and subscription download. Songs purchased from Rhapsody use RealAudio 10's flavor of copy-protected AAC, but Real's Harmony technology can convert them to either Secure WMA or Apple's FairPlay version of AAC.
The WMA conversion is done with Microsoft's blessing. But converting to Apple's format is shakier. Apple changed the iPod's built-in program in October 2004 to prevent Rhapsody songs from playing on newer iPod models. Rhapsody updated Harmony in April so that its tracks can once again play on iPods. But that may change if Apple changes its iPod software again. Apple declined to comment for this article.
The safest strategy, and one popular among audio purists, is to purchase music on compact discs and rip it to the MP3 format.
James O'Rourke, a software engineer in San Francisco who owns a 20-gigabyte iPod, said a friend told him that AAC had the best quality. "But then I thought, well, maybe I'll have a problem in the future with being able to transfer music between different players. So most of my CD ripping is now done in MP3."
That rules out the instant gratification of simply clicking "Buy Song" from an online store. And it means paying $10 to $20 for a CD rather than 99 cents a track or less for the songs you want.
But CD's still offer the greatest selection. Some of the most popular music of all time -- from bands like the Beatles, Led Zeppelin and AC/DC -- is still unavailable from legitimate online stores.
Ripping CD's can also offer higher quality. ITunes and some other stores sell music encoded at a data rate of 128 kilobits per second. (EMusic, Rhapsody and Yahoo use 192 kbps.) Typical CD's are encoded at a rate of about 1,400 kbps. AAC and WMA use sophisticated data-compression technologies that allow them to maintain audio quality at lower data rates than CD's or even MP3's can, but no one claims that a 128 kbps download is equivalent to a compact disc.
Those who have already ripped a lot of CD's into either the Apple or Microsoft format have the option of converting their music from one format to another. ITunes software, for example, can find WMA files on a computer and convert them to AAC. Windows Media Player does not have a similar ability to change AAC to WMA, but other programs can handle this. For instance, Switch, a free program from NCH Swift Sound (nch.com.au) can convert more than a dozen audio formats, including AAC, MP3 and WMA.
The main drawback is that most formats require a data compression method that tosses out some audio information to make files smaller.
Quality deteriorates when ripping CD's to WMA, for example, then deteriorates further when converting the WMA file to AAC. And converters do not work on copy-protected files from online music stores -- at least not without straying into troublesome legal terrain.
Some iPod owners, for example, use a program called JHymn (hymn-project.org/jhymndoc) to remove the copy protection from iTunes music downloads to convert or otherwise modify them without restrictions. The software also makes possible the sharing of copyrighted files, a use that JHymn's creators say they do not condone.
A federal law, the Digital Millennium Copyright Act, prohibits tampering with copy protection technologies. But JHymn's creators contend that the software, by allowing users to play songs purchased from iTunes on computers or devices that do not support Apple's system, merely enables a "fair use" allowed under traditional copyright law.
A JHymn representative, who goes only by the name FutureProof, however, acknowledged that using the software would almost certainly violate Apple's terms of service for iTunes.


Ranjana has demonstrated powerful leadership and support to Eli Lilly and Company through her engineering roles at insulin manufacturing plants. As a Process Engineer, she provided exemplary frontline support by monitoring and maintaining process equipment to achieve a reliable supply of high quality medicine while being safe and environmentally responsible. As a trusted resource among her peers, Ranjana has led a large portfolio of projects that have always been well understood by affected parties and delivered on time. Today, she continues to demonstrate her learning agility as she furthers her expertise in the company's computer system validation process.
As Chair of Lilly's Women Engineering Network (WEN), Ranjana leads efforts to unite and engage women engineers in all areas of the business through networking, building relationships, sharing experiences and more. Under her leadership, WEN has hosted several events including a Habitat for Humanity volunteering day, coffee chats and monthly mentoring circles. In addition to leading monthly professional, social and service events, Ranjana serves as a trusted coach and mentor to both process team members and frontline operations personnel. Focused on driving inclusive leadership, Ranjana also helped develop a reverse mentoring program for female talent to coach, educate and develop male members of the company's site leadership team by working with them on the unique challenges faced by women in manufacturing.
While volunteering at Engineering Explorers, Ranjana teaches local high school students about various engineering disciplines, coordinates student visits to local manufacturing sites and engineering colleges, and more. She also is involved with the Society of Women Engineers' community outreach group and volunteers regularly at events to promote STEM education in the area. Recently, she was among 20 volunteers to work with 38 Girl Scouts to help them earn Brownie Inventor Badges during a Rube Goldberg Event. Through the United Way's READUp program, Ranjana also works one-on-one with third grade students to improve comprehension and literacy skills.


text:
Tag Archives: randall munroe
Top Ten Tuesday: Nonfiction Books I Want to Read
Posted in Fun, Novels by Maggie @ macarons & paperbacks
This week I'm talking about one of my least familiar book genres: nonfiction. I have only read maybe a handful of nonfiction, autobiography, memoir, or humor novels, and I don't know what to say about that except I'm just not drawn to them naturally.
So to challenge myself a bit, I've compiled this list of ten nonfiction novels I'd like to read. And please, give me some good recommendations of nonfiction books to read for people who aren't huge fans of nonfiction!
Top Ten Nonfiction Novels I Want to Read
As You Wish by Cary Elwes
From actor Cary Elwes, who played the iconic role of Westley in The Princess Bride, comes a first-person account and behind-the-scenes look at the making of the cult classic film filled with never-before-told stories, exclusive photographs, and interviews with costars.
The Astronaut Wives Club by Lily Koppel
As America's Mercury Seven astronauts were launched on death-defying missions, television cameras focused on the brave smiles of their young wives. Overnight, these women were transformed from military spouses into American royalty.
Bossypants by Tina Fey
Before Liz Lemon, before "Weekend Update," before "Sarah Palin," Tina Fey was just a young girl with a dream: a recurring stress dream that she was being chased through a local airport by her middle-school gym teacher. She also had a dream that one day she would be a comedian on TV.
She has seen both these dreams come true.
What If?: Serious Scientific Answers to Absurd Hypothetical Questions by Randall Munroe
Randall Munroe left NASA in 2005 to start up his hugely popular site XKCD 'a web comic of romance, sarcasm, math and language' which offers a witty take on the world of science and geeks. It's had over a billion page hits to date. A year ago Munroe set up a new section – What If – where he tackles a series of impossible questions: If your cells suddenly lost the power to divide, how long would you survive? How dangerous is it, really, in a pool in a thunderstorm? His answers are witty and memorable and studded with hilarious cartoons and infographics. Far more than a book for geeks, WHAT IF explains the laws of science in operation in a way that every intelligent reader will enjoy and feel the smarter for having read.
Choose Your Own Autobiography by Neil Patrick Harris
Tired of memoirs that only tell you what really happened?
Sick of deeply personal accounts written in the first person? Seeking an exciting, interactive read that puts the "u" back in "aUtobiography"? Then look no further than Neil Patrick Harris: Choose Your Own Autobiography! In this revolutionary, Joycean experiment in light celebrity narrative, actor/personality/carbon-based life-form Neil Patrick Harris lets you, the reader, live his life. Choose correctly and you'll find fame, fortune, and true love. Choose incorrectly and you'll find misery, heartbreak, and a hideous death by piranhas. All this, plus magic tricks, cocktail recipes, embarrassing pictures from your time as a child actor, and even a closing song.
One More Thing by B.J. Novak
B.J. Novak's One More Thing: Stories and Other Stories is an endlessly entertaining, surprisingly sensitive, and startlingly original debut collection that signals the arrival of a welcome new voice in American fiction. Finding inspiration in questions from the nature of perfection to the icing on carrot cake, from the deeply familiar to the intoxicatingly imaginative,One More Thing finds its heart in the most human of phenomena: love, fear, family, ambition, and the inner stirring for the one elusive element that might make a person complete. The stories in this collection are like nothing else, but they have one thing in common: they share the playful humor, deep heart, inquisitive mind, and altogether electrifying spirit of a writer with a fierce devotion to the entertainment of the reader.
Food: A Love Story by Jim Gaffigan
"What are my qualifications to write this book? None really. So why should you read it? Here's why: I'm a little fat. If a thin guy were to write about a love of food and eating I'd highly recommend that you do not read his book."
Bacon. McDonalds. Cinnabon. Hot Pockets. Kale. Stand-up comedian and author Jim Gaffigan has made his career rhapsodizing over the most treasured dishes of the American diet ("choking on bacon is like getting murdered by your lover") and decrying the worst offenders ("kale is the early morning of foods").
The Boys in the Boat by Daniel James Brown
Daniel James Brown's robust book tells the story of the University of Washington's 1936 eight-oar crew and their epic quest for an Olympic gold medal, a team that transformed the sport and grabbed the attention of millions of Americans. The sons of loggers, shipyard workers, and farmers, the boys defeated elite rivals first from eastern and British universities and finally the German crew rowing for Adolf Hitler in the Olympic games in Berlin, 1936. Drawing on the boys' own diaries and journals, their photos and memories of a once-in-a-lifetime shared dream, The Boys in the Boat is an irresistible story about beating the odds and finding hope in the most desperate of times—the improbable, intimate story of nine working-class boys from the American west who, in the depths of the Great Depression, showed the world what true grit really meant.
Bonus: Documentaries I Want to Watch
David Sington and Christopher Riley's acclaimed documentary reveals the history of the Apollo space program through interviews with the brave astronauts who lived through a paradigm-shifting chapter in world history. Devoted to President John F. Kennedy's goal of sending a man to the moon, the NASA project pushed the envelope of what was humanly possible. But the program also experienced several failures, one of which resulted in tragedy.
Philippe Petit captured the world's attention in 1974 when he walked across a high wire between New York's Twin Towers. This Oscar winner for Best Documentary explores the preparations that went into the stunt as well as the event and its aftermath.
as you wish, autobiography, bj novak, bossypants, cary elwes, choose your own autobiography, daniel james brown, documentary, food a love story, humor, in the shadow of the moon, jim gaffigan, lily koppel, man on wire, memoir, neil patrick harris, nonfiction, nonfiction books, nonfiction novels, nph, one more thing, randall munroe, the astronauts wives club, the boys in the boat, the princess bride, tina fey, top ten tuesday, what if 42 Comments

redpajama_set_name: RedPajamaCommonCrawl


DestinationBCN offers stylish centrally located apartment suites and rooms for short and longer stays in the heart of one of the world's most vibrant cities and key European business locations. The apartments and rooms, each with an individual name and identity and striking original features, permit the discerning visitor to partake in an extraordinary Barcelona experience.
All apartments and rooms enjoy a privileged location in an historic building the heart of the city, absorbing and radiating culture and history. Thoughtful, individually and carefully sourced elements ensure that no two rooms or apartments are the same: the unique character of every last detail has been carefully created to adapt to a range of tastes and requirements. Lavish bedrooms come with crisp Egyptian cotton sheets, Swissflex beds and a choice of goose down or anti-allergic pillows.
Additional touches such as a plate of crispy chocolate biscuits, a bottle of flat and sparking water, a wine list and lifestyle, art and design books for leisurely reading is a true reflection of the way in which the company likes to host and make guests feel welcome.
Subtlety, style and practicality fuse to offer alternative, adaptable accommodation that caters for professional visitors as well as families and couples.
Our apartments offer a complimentary selection of Malin+Goetz natural skin and hair products, a little treat at your home from home. You will find nourishing Peppermint Shampoo, purifying Dark Rum Body Wash and hydrating Cilantro Conditioner to ensure that you feel invigorated during your time with us. You can even buy a mini travel kit for yourself or others, perfect for any product lover.
We all love goodies and treats. Please help yourself to Novell coffee capsules, Sans & Sans tea, Sant Aniol still and sparkling water, fresh fruit and crispy chocolate biscuits. Just a little something to make your stay with us even better!


Ultrasound has developed over the past 50 years into a major diagnostic imaging modality, complementing CT, MRI and nuclear imaging. Major applications of ultrasound today include cardiovascular, abdominal organs, muskloskeletal, small parts, and OB/Gyn. Increased clinical usage of ultrasound has been driven by technological advances that exploit the following advantages compared to other modalities: real-time (especially important for heart and blood flow), safe due to non-ionizing radiation, portable, and low cost. Basic ultrasound modes include B-mode that images the acoustic reflectivity of tissue structures and Doppler that measures blood velocity. Recent advances include harmonic imaging that improves image quality by exploiting the nonlinear behavior of high-amplitude ultrasound propagation in tissue or micro-bubble contrast agents, and code technology that circumvents traditional resolution / penetration tradeoffs. Future directions for ultrasound are at the intersection of clinical needs (image quality, new applications, and increased productivity) and major technological trends (miniaturization, SW), which include miniaturized systems and probe components, improved image quality, new imaging parameters, and 4D imaging.


text:
Physionotrace is een in 1785 uitgevonden procedé waarbij een gezicht wordt afgetast met een stift die verbonden was aan een tekenstift die de contouren van het gezicht op een stuk papier overbracht. Hierdoor is het mogelijk om portretten van personen en profil te maken.

De techniek is een uitvinding van Gilles-Louis Chrétien (1745-1811), musicus bij de hofkapel van Versailles, graveur en portrettist.

Kunst
Fotografie

redpajama_set_name: RedPajamaWikipedia


text:
Forever blowing bubbles
Originally posted in May 2011.
"For ever": these two words, when used together, are so poetic and so laden with meaning. In their definitiveness they conjure up the most extreme notions and emotions of the human condition: eternities of love, of despair, of hope, of estrangement, of desire, of determination, of life itself and even the hereafter. The words can't be used lightly, whether they're whispered or declared in the context of a single mortal lifespan or the unfathomable eternity of the universe; their meaning carries a certain gravitas in terms of time and intention. "I will stay here for ever" has no ambiguity about it. The OED defines the expression "for ever" as "for all future time" – or, more colloquially, "for a long time". But put those two little words together, and here's where the Americans and the Brits part company.
In British English, "forever" means something quite different – and moves from the poetic to the more prosaic when the words are joined as one. The single-word adverb (according to the OED) means "continually, persistently": "The dog is forever eating her homework." "He is forever complaining." Suddenly the eternity embedded in those two future-laden words loses some of its weightiness and invades the mundanity of our daily existence: "I'm forever cleaning up after your mess!" Curiously, when used strictly as an adverb (describing a verb), it tends to have slightly negative connotations – implying that the action described is unwanted or irritating, and the hope is that it will certainly not continue for ever. And yet, when used to qualify an adjective, the word often resumes the poetic nature and more of the meaning of its component parts: "May you stay forever young." "She remained forever faithful." "You're forever true."
Americans forever join the two words, so the distinction in meaning is implied only by the context and sentence structure. "I will love you forever" and "I'm forever loving you" mean subtly different things, and perhaps for the reasons I've suggested above, the second sentence is unlikely to be expressed as such.
But maybe I'm wrong about the British "forever" always suggesting something annoying or undesirable. After all, what are the fans of West Ham United doing forever?
West Ham anthem on YouTube
Bob Dylan\'s \"Forever Young\" on YouTube
This entry was posted in Grammar, Yanks vs. Brits and tagged British American words, for ever, forever, I'm forever blowing bubbles on August 27, 2019 by Louise.
← That prat skived off to scoff his spotted dick, the jammy b… To prorogue or not to prorogue →
2 thoughts on "Forever blowing bubbles"
Barrie England May 16, 2011 at 5:48 am
In 'The Cambridge Guide to English Usage', Pam Peters reports that the tendency to use joined-up 'forever', in all senses, is as strong in the British National Corpus as it is in the Cambridge Corpus of American English and suggests the process of closing up matches that of forms such as 'however' and 'wherever'. I don't think that that spells the end of the difference, although the placing of the adverb is crucial. 'He'll be bothering her forever' is always going to mean something different from 'He'll be forever bothering her.'
You may be right about it carrying a negative sense when used as an adverb and a positive one when modifying an adjective. In support of the latter, Keat's 'Ode on a Grecian Urn' comes to mind:
'More happy love! more happy, happy love!
For ever warm and still to be enjoy'd,
For ever panting, and for ever young;'
Barrie England May 16, 2011 at 2:10 pm
*Keats's*


text:
The Aer-Pegaso M-100 was a single-seat glider designed and built in Italy from 1957.

Development
The Morelli M-100 was a single-seat sailplane designed in response to a 1956 competition sponsored by the Aero Club d'Italia for a low-cost training glider. The winning design, by Prof. Ing. Piero Morelli, was put into production the following year. As originally designed, the M-100 was of conventional, high-wing sailplane configuration, with a stubby T-tail.

In 1958, the FAI published the new Standard Class rules for sailplanes, and since the M-100 was close to this specification, the design was modified to comply. This involved numerous changes to the wing, including lengthening and thickening the structure, and adding larger and more numerous rotating airbrake segments. The tail unit was revised too, and given a conventional fin. This version was designated the M-100S.

The M-100 and M-100S were manufactured by Aeromere, CVT, Avionautica Rio in Italy, and S.A. CARMAM, in France as the CARMAM M-100S Mésange (tomtit). Eighty three aircraft were built in Italy and a further 140 at CARMAM in France.

Variants
Morelli M-100 A generic designation for all variants.
CVT M-100Prototype and initial production at the Centro di Volo a Vela del Politecnico di Torino (CVT) in Turin, in the Ditta Nicolotti & Figli factory in Turin.
Morelli M-100S A substantial re-design to comply with new Standard class specifications issued in 1957.
Aeromere M-100S The bulk of production from the Aeromere factory.
Avionautica Rio M-100S Alternative production in Italy
CARMAM M-100S Mésange (Tomtit) Production at the CARMAM (Coopérative d'Approvisionnement et de Réparation de Matériel Aéronautique de Moulins) factory in France, (140 built).
Aer-Pegaso M-100S Another designation for some aircraft built in Italy.

Specifications (M-100S)

See also

References

Notes

Bibliography

 Coates, Andrew. Jane's World Sailplanes & Motor Gliders new edition. London, Jane's. 1980.
 Taylor, J. H. (ed) (1989) Jane's Encyclopedia of Aviation. Studio Editions: London. p. 29
 Historical Aircraft Group, Italy website

Glider aircraft
1950s Italian sailplanes
M-100
High-wing aircraft
Aircraft first flown in 1957


Designed to form the building blocks of a modern wardrobe, our short and long-sleeved T-shirts are simple and versatile. The collection incorporates everything from basic round-neck T-shirts and V-neck T-shirt styles, to inventive new takes on this wardrobe essential. Fabrics are tactile and considered, in smooth pima cotton and soft jersey. Choose from timeless colours and graphic striped T-shirts.


text:
Út Sneek is een groot cultureel festival in de binnenstad van de Nederlandse stad Sneek.

Tijdens het festival presenteren alle culturele gezelschappen van de stad zich aan het publiek. Aan het festival doen meer dan 1.000 deelnemers mee. Zij vertegenwoordigen professionele culturele instellingen, alsook veel amateurmusici die spelen of zingen in popbands, koren of harmonie- en fanfareorkesten.  Het festival wordt sinds 2002 georganiseerd door de Sneker horeca en middenstand in samenwerking van het Cultureel Kwartier en de scholengemeenschap Bogerman en vindt plaats op de tweede zaterdag van juni. Het Sneeker Nieuwsblad komt in de week voor het festival met een extra uitgave, welke geheel is gewijd aan het festival.

Evenement in Sneek
Festival in Nederland


text:
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN"
  "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">

    <meta http-equiv="Content-Type" content="text/html; charset=utf-8" />

  <title>IMPLICIT_DEPENDS_INCLUDE_TRANSFORM — CMake 3.8.1 Documentation</title>

    <link rel="stylesheet" href="../_static/cmake.css" type="text/css" />
    <link rel="stylesheet" href="../_static/pygments.css" type="text/css" />

    <link rel="shortcut icon" href="../_static/cmake-favicon.ico"/>
    <link rel="index" title="Index" href="../genindex.html" />
    <link rel="search" title="Search" href="../search.html" />
    <link rel="next" title="IMPORTED_CONFIGURATIONS" href="IMPORTED_CONFIGURATIONS.html" />
    <link rel="prev" title="HAS_CXX" href="HAS_CXX.html" />

Navigation

          index

          next |

          previous |

    CMake »

    3.8.1 Documentation »

cmake-properties(7) »

IMPLICIT_DEPENDS_INCLUDE_TRANSFORM¶

Specify #include line transforms for dependencies in a target.

This property specifies rules to transform macro-like #include lines
during implicit dependency scanning of C and C++ source files.  The
list of rules must be semicolon-separated with each entry of the form
“A_MACRO(%)=value-with-%” (the % must be literal).  During dependency
scanning occurrences of A_MACRO(...) on #include lines will be
replaced by the value given with the macro argument substituted for
‘%’.  For example, the entry

MYDIR(%)=<mydir/%>

will convert lines of the form

#include MYDIR(myheader.h)

to

#include <mydir/myheader.h>

allowing the dependency to be followed.

This property applies to sources in the target on which it is set.

Previous topic

HAS_CXX

Next topic

IMPORTED_CONFIGURATIONS

This Page

Show Source

Quick search

    <form class="search" action="../search.html" method="get">

<input type="text" name="q" />

<input type="submit" value="Go" />

      <input type="hidden" name="check_keywords" value="yes" />
      <input type="hidden" name="area" value="default" />
    </form>

Navigation

          index

          next |

          previous |

    CMake »

    3.8.1 Documentation »

cmake-properties(7) »

        © Copyright 2000-2017 Kitware, Inc. and Contributors.
      Created using Sphinx 1.5.2.

redpajama_set_name: RedPajamaGithub


← The things readers hate…or do we?
The reasons I haven't blogged for a few weeks are mostly of the 'life got in the way of relaxation' variety that would even bore me if I re-hashed them again. But one factor I hadn't considered might play a role in my interest in talking about books was their physical absence from my surroundings.
With my recent house move (one I fervently hope will be my last) I decided that my new house would also have new bookshelves. I'd had the same IKEA shelves since first leaving university in 1988 and while they served me faithfully through countless moves and re-configurations the time felt right for something different. So I packed almost all of my books away in late January when I was getting the old house ready for sale and, aside from a couple of boxes which I opened when I moved here in June, they have stayed packed away until this week when my new shelves finally arrived.
And for almost all of that time I have grown decreasingly interested in reading, talking about reading, book shopping and all the other things that go with being a lifelong bookaholic. It's not a matter of having something to read either as I deliberately kept some of my physical TBR accessible, have oodles of eBooks available and for the last four months have been living 500 metres from one of the city's best book stores. But having something to read is not the same as being surrounded by reading memories. Or being able to easily lay one's hand on a favourite book to loan to an old friend. Or having a quick re-read of my grandmother's copy of Wuthering Heights before seeing the newest movie adaptation.
I'm not suggesting that 2012's lost reading mojo can entirely be ascribed to an absence of books but my lack of interest in all things book-related coincides too closely with my books being in boxes for it not to be remarked upon My new shelves arrived on Tuesday this week and almost as soon as I'd unpacked the last book box late that night I felt better than I have in ages. All year really.
Books are now the first thing I see when I walk in the front door and I hope that will always make me smile as much as it did tonight. In the past two days I've read more than I have in the last month (I'm half-way through a book I dared not start during my slump for fear of not doing it justice). And I'm mentally reviewing my wishlist, thinking of things to blog about and wondering once again if I can read until 3AM and still look like I give a damn about work the next day.
Bernadette I am pleased you are feeling much better and have recaptured your reading mojo. I think sometimes you have to take a break from reading especially after mentally exhausting efforts like moving house. Best wishes.
Am glad to hear from you, Bernadette.
stock the used bookstore I hoped to have after retiring.
Oh, I had some friends that had books in every room in their house except the kitchen. Even the main bathroom had bunches of books………wonderful for visitors…..
That sounds just perfect Jane…books hidden away all over the place. I was just looking at the spare bedroom and thinking that I could fit a little table/bookcase by the bed to offer some relief to any visitors who pop by.
I'm sure you're not alone in dreaming of a used bookstore after retirement – I still daydream about winning the lottery and opening such a store and then it wouldn't matter if I didn't make any money but I'd still be in heaven.
I had about 15 boxes of old Canadian case reports that we were no longer using in my law office. I was going to give them to the local museum when my sons, 27 and 29, who are in law school and a lawyer respectively said they wanted them. Sharon and I took them the 800 km to Calgary and they are now looking good in bookcases around the living room of our sons.
I do like the idea of those old case reports lingering in the living rooms – and minds – of the next generation of lawyers Bill – there's a lot to be said for that kind of continuity.
Thanks very much Carla…so amazing to be missed from the other side of the world.
Bernadette: Did not realize until after posting that my name had not been recorded on the comment on law books.
Welcome back Bernadette, you've been missed. And congratulations on not only finally settling into your new abode, but also on being so aware of the impact of your surroundings on your state of mind. Do you think you suffered something akin to homesickness in missing your books?
I suppose it is something like homesickness Beth – I'm not much of a hoarder so don't have lots of other "stuff" around – just a few things that are precious because of some memory they evoke and collectively I think my books are one of those precious things. I've been without them before when on long trips but never before been at home without having books around me. Not something I plan to repeat.
There is no way a house is a home without books. That would feel like living in a motel room to me. They're part of who we are, our pasts and present.
Glad you've settled in and that your books are nearby.
I couldn't sleep at night if my bookshelf in my bedroom wasn't filled with books I love.
Am glad RTR is up and running again.
I am sure your house now feels complete with its bookshelves. I've missed your reviews and look forward to your renewed enthusiasm and hence reading more of them.
Glad to see you back Bernadette. I know exactly what you mean. I have boxes adn boxes of books waiting for bookshelves so I can unpack them. To be honest, I don;t miss the books at the moment but I'll like it when they are all unpacked.
I thought it's great to have a hallway shelf! I just stack my books which couldn't fit into any shelf on the floor and stack them all the way up to the ceiling.! I noticed your absence but I know that you are enjoying yourself and taking a good break from blogging. Glad you are back though.


text:
motoclubpiacenza » Electronic » Absonant Digression - In A World Of Complete Black
Absonant Digression - In A World Of Complete Black FLAC
Performer: Absonant Digression
Title: In A World Of Complete Black
Label: Not On Label (Absonant Digression Self-released)
Style: Industrial, Ambient
Absonant Digression Greece Not Label Absonant Digression Self Released Industrial Ambient 2008
1 Intro 1:39
2 Dance On Your Minced Knee 5:16
3 In Sickness We Find Salvation 6:33
4 Re Cleance
Written-By – Neurosis
5 Bouncing 2:35
6 In A World Of Complete Black 5:42
7 From The Ruins Of Your World 3:13
8 The Margins Expand 3:52
9 Minced Rotten Mankind 3:36
10 Audioterror 3:19
Sampler, Programmed By – Abused
Top Tracks, View All. in sickness we find salvation. in a world of complete black. the margins expand. all different all equal. High quality vinyl album. Full colored inner and outer sleeves. Includes unlimited streaming of Merkaba via the free Bandcamp app, plus high-quality download in MP3, FLAC and more. ships out within 7 days. Buy RecordVinyl. Digression Assassins creates the sort of music that will take you out of your comfortzone and demand that you think. With angular stabs of guitar,obsessive-compulsive percussion and haunted vocals its music that will rearrange your understanding of what heavy music should, and can, sound like. Listen to online Absonant Digression - In A World Of Complete Black, or download mp3 tracks: download here mp3 release album free and without registration. On this page you can not listen to mp3 music free or download album or mp3 track to your PC, phone or tablet. Buy Absonant Digression - In A World Of Complete Black from authorized sellers. Released at: This album was released on the label Not On Label Absonant Digression Self-released catalog number none. This album was released in 2008 year. Format of the release is. A statue of the 19th Century US black activist Frederick Douglass has been toppled in New York state. It appears to have been vandalised on 5 July - the anniversary of a famous speech the former slave gave in 1852. In it he said Independence Day celebrations were a sham in a nation that still enslaved its black citizens. His statue, in the city of Rochester, could have been targeted in retaliation for attacks on monuments linked to slavery, activists said. The leader of the group that erected the statue, Carvi Eison, said a new statue of Douglass would take its place. No-one has so far claimed. Absonant Digression. Title: In A World Of Complete Black. FLAC size: 1583 mb. MP3 size: 1500 mb. Other formats. Aa wav adx mod MIDI au vqf. Label: Not On Label Absonant Digression Self-Date of released none Type: CDr, Album Country: Greece Date of released: 2008 Category: Electronic Style: Industrial, Ambient. Rating: 4. Votes: 280. Free Download links. Absonant Digression - In A World Of Complete Black MP3 version. Getting through WW2 with the US at Hard Difficulty Black ICE MOD - BLACK ICE is Life Deep immersive Micromanagemant Campaign at the most complex Digression. A blog on the Civil War era and other musings on early American history. There was a whole world of activity going on here for four years. Worthy of further study. 10 June 2016 . Wandered today to take some photos for my talk tomorrow at the Alden House on the Almost-Battle of April 21, 1775. BBC World Service has been listening in to some of what is being said on black-owned radio stations across the United States. As part of a series called Black America Speaks, listeners have been on a virtual road trip across the US from Philadelphia to Los Angeles via Chicago and Houston. Across the US, 13 of the population identifies as being black, yet only 1. 6 of commercial radio stations in the country are black-owned, according to the National Association of Black Owned Broadcasters. A World of Our Own is the fourth studio album by the Australian group The Seekers. The album was released in 1965. In some countries, the album was titled The Seekers. The album peaked at number 19 in the Billboard 200 and number 5 in the United Kingdom. But the rest is rather ho-hum fare in the style of Peter, Paul & Mary with a slightly more prominent beat. Узнавайте о релизах, читайте рецензии, изучайте композиция дорожка трек-листы, рекомендации и прочую информацию о Bob Dylan - The Complete Album Collection Vol. Формируйте собственную коллекция коллекцию записей Bob Dylan
Albums related to Absonant Digression - In A World Of Complete Black:
Andrew hill complete blue note - Complete Blue Note Andrew Hill Sessions (1963-66)
Lee & Sun - Feel Complete
The Clash - Complete Control (Live)
Jaimeson - Complete (UK Garage Mixes)
Obituary - The End Complete
Jacques Offenbach, Eugene Ormandy, The Philadelphia Orchestra - Gaîté Parisienne (Complete)
Charlie Parker - The Complete Charlie Parker
Claudio Arrau - Chopin: Complete Preludes


Fishbourne Primary School - What are British Values?
As a school community, we do not explicitly promote 'British' values. However, these values naturally embody our approach to the opportunities and experiences on offer throughout our learning community.
Our youngest children hold a vote within days of starting Fishbourne CE Primary School to decide on their class name… this name follows them through school – reflecting their unique character as a cohort. As they enter KS2, the class have the opportunity to vote again and change their name if they would like to.
Thinking Circles replaced School Council at Fishbourne CE Primary in September 2017– giving every child a voice and an opportunity to comment on and vote on key issues impacting on school life. Recent achievements of these circles include the rewriting of our Home-School agreement.
We involve all our families and children in voting for projects that our wonderful FOFS team oversee.
At the beginning of each academic year, during our 'Getting to know you' learning experiences, each class draws up an agreement centred on the expectations of children as members of the learning community.
Children, teachers and parents worked together to rewrite our home-school agreement in the spring of 2018, focussing on our learning behaviours: courage, determination, positivity, reflection and collaboration.
Our school motto, 'Only One You', celebrates the individuality of every child and adult in our care. We know that each of our children is unique: each has their individual personality, strengths, interests and learning style.
Whether it be through choice of learning challenge, of how we record our ideas or present our learning, participation in our numerous extra-curricular clubs, the children are given the freedom to make choices and follow their own lines of enquiry.
The children write their own school reports during the early part of the spring term, during which they are encouraged to reflect on themselves as unique individuals.
Children identified through our 'home-school agreement' that they aspire to be collaborative learners by respecting others, listening to their ideas and supporting the learning of other children in school.


text:
CNIO Friends
CNIO and Society
About the CNIO
What is it we do
Thanks to our friends donations
Other contributions: CNIO Arte
CNIO News
CNIO Friends Newsletter
Scientific News
CNIO-"la Caixa" Foundation Frontiers Meetings
Distinguished Seminar
Women in Science Office Seminar
Scientific Programmes
CNIO Euality Plan
Contacts & Suggestions
Career Development Programmes
CNIO Open doors
CNIO Friends welcomes Víctor Frankenstein
Home | News | Basic Research | CNIO researchers cure lung fibrosis in mice with a gene therapy that lengthens telomeres
eLife. CNIO researchers cure lung fibrosis in mice with a gene therapy that lengthens telomeres
Maria A. Blasco: "For the first time, pulmonary fibrosis has been treated by rejuvenating the affected tissues"
Pulmonary fibrosis affects 8,000 people in Spain. Nowadays, there is no cure
Two months after treatment with telomerase, fibrosis had "improved or disappeared"
Idiopathic pulmonary fibrosis is a potentially lethal disease associated with the presence of critically short telomeres, currently lacking effective treatment. The Telomere and Telomerase Group at the Spanish National Cancer Research Centre (CNIO) has succeeded in curing this disease in mice using a gene therapy that lengthens the telomeres. Their work constitutes a "proof of concept that telomerase activation represents an effective treatment against pulmonary fibrosis," the authors write in their publication in the journal eLife. Given that telomere shortening is also an indicator of organism ageing, Maria A. Blasco, lead author of the paper, points out that "this is the first time that pulmonary fibrosis has been treated as an age-related disease, looking for rejuvenating the affected tissues".
"The most relevant aspect of our work is that it suggests a potentially viable and effective solution to a real clinical problem, pulmonary fibrosis, for which there is still no treatment," says Paula Martínez, co-first author of the paper. "The only approved treatments for pulmonary fibrosis up-to-date have no curative effects, as they target a symptom and not the cause of fibrosis. Our therapy is based on correcting the molecular cause of pulmonary fibrosis in patients with short telomeres, introducing into the cells of damaged lung tissue the only enzyme capable of lengthening telomeres, telomerase. "
Telomeres are protein structures located at the ends of each chromosome; like caps, they protect the integrity of the chromosome when the cell divides. But telomeres only fulfill their protective function if they are long enough; when they shorten too much, the damaged cells cease to divide preventing tissue regeneration. Short telomeres are associated with ageing –as age increases, cells accumulate more divisions and more telomeric shortening– and also with several diseases. Pulmonary fibrosis, which affects around 8,000 people in Spain, is one of them.
In lung fibrosis, the lung tissue develops scars that cause a progressive loss of respiratory capacity. Environmental toxins play an important role in its origin, but it is known that there must also be telomeric damage for the disease to appear. Patients with pulmonary fibrosis have short telomeres whether the disease is hereditary –it runs into the family– or not. The most likely explanation is that when the telomeres become too short, the damaged cell activates a 'repair program' that induces scar formation that leads to fibrosis.
The best animal model available
The CNIO Telomere and Telomerase Group, led by Blasco, decided to address the problem about five years ago, starting with the development of an animal model that faithfully reproduces the human disease. The most widely used model until then was to apply bleomycin into the mouse lungs to induce damage, in an attempt to reproduce the environmental insult. However, in these animals the disease goes into remission in a few weeks and there is not telomere shortening.
The CNIO researchers sought after a mouse model in which the environmental damage synergized to that produced by short telomeres, that is what happens in human pulmonary fibrosis. They succeeded in 2015, when they already indicated their next goal in their research work: "This is an essential model to test therapeutic strategies based on the activation of telomerase [the enzyme that repairs the telomeres]", they wrote in the journal Cell Reports.
Their current publication shows that activating the telomerase enzyme to lengthen the telomeres in the lung tissue may constitute an effective therapeutic strategy to treat human pulmonary fibrosis. It has proven so in mice. Only three weeks after treatment, the sick animals "showed improved lung function and less inflammation and fibrosis" –the authors write in eLife–; two months after the treatment, the fibrosis had "improved or disappeared".
A genetic driver
The treatment consisted of introducing the telomerase gene into the lung cells using gene therapy. The researchers first modified a virus innocuous to humans (known as vectors) so that their genetic material incorporated the telomerase gene, and then injected those vectors into the animals. The animals received a single injection of this genetic taxi.
As Juan Manuel Povedano, co-first author of the paper, explains, "we observe that telomerase gene therapy reverses the fibrotic process in mice, which suggests that it could be effective in human patients, opening a new therapeutic opportunity towards the treatment of this disease". Povedano is now a postdoctoral researcher at the Southwestern Medical Center at the University of Texas, USA.
The work has been carried out in collaboration with the gene therapy expert Fàtima Bosch, from the Autonomous University of Barcelona, ??with whom the first steps will also be taken to bring this therapy closer to its use in humans. "The strategy devised by the CNIO group is very encouraging," says Bosch; "although we are still far from reaching the clinic, we are already generating gene therapy vectors for human therapy".
The basis of this work is the hypothesis that age-associated diseases can be treated by targeting the molecular and cellular processes of ageing, specifically telomere shortening. In 2012, Blasco and her group generated mice that not only lived longer but also showed improved health by treating them with telomerase. Her work since then has aimed to develope this therapy to specifically treat age-associated diseases and telomere syndromes.
They have obtained positive results in the treatment of heart infarct, aplastic anemia and, now, pulmonary fibrosis. In the case of heart infarct, research to bring therapy to the clinic is already underway, in collaboration with the Fàtima Bosch's group and Francisco Fernández-Avilés, Head of the Cardiology Service at the Hospital General Universitario Gregorio Marañón.
This research has been funded by the Spanish Ministry of Economy, Industry and Competitiveness (MINECO), the Botín Foundation and Banco Santander through Santander Universities and the Roche Extending the Innovation Network Program (EIN).
Paula Martínez (left) and Maria A. Blasco (right), first authors or the paper./ CNIO
Reference article
Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres. Juan Manuel Povedano, Paula Martinez, Rosa Serrano, Agueda Tejera, Gonzalo Gomez, Maria Bobadilla, Juana Maria Flores, Fatima Bosch and Maria Blasco (eLife 2018). DOI: 10.7554/eLife.31299
Help us out in the fight against cancer
Donate Newsletter
Privacy Policy and the Use of Cookies
We use cookies to ensure that we give the best user experience on our website.OKPolítica de privacidad


Does Value-at-Risk Give a False Sense of Security in the Swedish Stock Market? : An empirical study of the accuracy of Value-at-Risk in the Swedish stock market.
Does Value-at-Risk Give a False Sense of Security in the Swedish Stock Market?: An empirical study of the accuracy of Value-at-Risk in the Swedish stock market.
This thesis will test the accuracy of parametric and non-parametric Value-at-Risk as a risk measure for the swedish stock market. The idea that VaR is a powerful tool of measuring risk that can be understood by all levels of management and regulators has made the approach very popular and is now an industry standard. Many models assume normal distribution and doesn't take into account the possibility of fat tails. This empirical study of the 30 biggest stocks on the Stockholm stock exchange and the index OMXS30 will show that both parametric and non-parametric VaR underestimates the frequency of VaR breaks.


The Menier Chocolate Factory announces its 2012 season, following on the success of Abigail's Party, its fastest selling play to date. The forthcoming season for main house shows runs from May 2012 and to February 2013.
Torch Song Trilogy by writer and actor Harvey Fierstein will play from 30th May to 12th August, and is directed by actor and director Douglas Hodge. Hodge won the Olivier award in 2009 and the Tony award in 2010 for his role as Albin in the Chocolate Factory production of La Cage aux Folles – also written by Harvey Fierstein. Advance tickets for this production go on sale to Chocolate Factory Supporters from 9th April, with general public sales from 18th April.
This Tony award winning drama tells the poignant story of an outsider's search for love and acceptance. Originally conceived and performed in three acts, drag queen Arnold encounters passion, thrills, love and loss. This intimate and powerful play is bursting with courage and sharp wit, as Arnold fights for his place in the world and his right to happiness.
Charley's Aunt by Brandon Thomas plays from 20th September to 10th November. Ian Talbot returns to the Chocolate Factory following his production of The Invisible Man in 2010 to direct. Advance tickets for this production go on sale to Chocolate Factory Supporters from 2nd July, with general public sales from 11th July.
The Stephen Sondheim/George Furth musical Merrily We Roll Along will play from 16th November to 23rd February 2013. The musical is directed by Olivier award winning actress Maria Friedman, who returns to the Chocolate Factory for her directorial debut, following the success of her show Maria Friedman: Re-arranged and the 2010 production of The Invisible Man. Advance tickets for this production go on sale to Chocolate Factory Supporters from 3rd September with general public sales from 12th September.
Based on the play by George S. Kaufman and Moss Hart, Stephen Sondheim and George Furth's musical charts the relationship of three friends over three decades in the entertainment business. This moving story features some of Sondheim's most beautiful songs including 'Good Thing Going', 'Not a Day Goes By' and 'Old Friends'.


text:
Queenie Wong
@QWongSJ
qwong@bayareanewsgroup.com
Queenie Wong covers social media businesses, including Facebook, Twitter and LinkedIn, for The Mercury News. She grew up in Southern California and is a graduate of Washington and Lee University where she earned bachelor's degrees in journalism and studio art.
Tweets by Queenie Wong
Facebook's Oculus woos virtual reality game makers with millions
Facebook's Oculus is throwing big money at luring in more game developers, but will their long-term bet on virtual reality pay off?
H-1B visas: How the Trump administration is 'freaking people out'
February 20, 2018 at 6:00 a.m.
The increased scrutiny of H-1B visa applications is creating a legal headache for immigration lawyers, employers and workers.
Twitter shares surge after reporting first profitable quarter
February 8, 2018 at 4:30 a.m.
Twitter on Thursday reported fourth-quarter revenue and earnings that topped Wall Street's expectations.
Facebook boycott: Jim Carrey urges users to delete their accounts and dump stock
February 6, 2018 at 3:14 p.m.
Facebook has been under pressure to do more to protect election integrity after the 2016 U.S. presidential election.
Facebook's Sheryl Sandberg weighs in on 'Pence rule' amid fears about #MeToo backlash
A survey conducted this year by LeanIn.Org and SurveyMonkey shows that a higher percentage of male managers are uncomfortable working with a women or mentoring them.
Twitter users fooled by fake Trump tweet about the 'Dow Joans'
A Twitter user tweeted out an image of a fake tweet he claimed was from President Donald Trump after the Dow Jones Industrial Average's plunge on Monday. It was a...
Facebook CEO Mark Zuckerberg says users are spending less time on the social network
Facebook's adjusted earnings and revenue beat Wall Street's expectations, but the tech firm's CEO Mark Zuckerberg acknowledged people are spending less time on the social network.
Facebook explains how it will prioritize local news
Facebook CEO Mark Zuckerberg on Monday said that "local news helps build community -- both on and offline."
Facebook, Microsoft and other tech firms support bill to increase H-1B visas
A bill introduced Thursday by two U.S. Republican senators would allow up to 195,000 H-1B visas based on demand.
Meet the CEO behind Blind, an anonymous chat app that has tech workers talking
Thousands of tech workers, including from Microsoft, Google and Facebook, are getting the inside scoop on the anonymous chat app Blind. In a Q&A, Blind's CEO and co-founder talks about...
Public Notes


text:
Jane Egan
Jane was new to triathlon in 2009 but became a World and European Champion in 2010 - she was recognised for this spectacular breakthrough by being voted British Triathlon's female Paratriathlete of the Year for 2010.
She was selected for the British squad unexpectedly when she went to be classified as a Tri1 Paratriathlete. She did her first triathlon in 2009 and 2010 has been her first full season.
Jane has a rare neurological disorder affecting her central and peripheral nervous systems, which means she experiences pain and little muscle control.
2014 Madrid ITU World Paratriathlon Event
21 Sep, 2014 - Women's PT1 - 01:55:45
2014 ITU World Triathlon Grand Final Edmonton
30 Aug, 2014 - Women's PT1 - 01:26:49
2014 GBR Paratriathlon National Championships
2014 Iseo - Franciacorta ITU World Paratriathlon Event
05 Jul, 2014 - Women's PT1 - 01:21:45
2014 Kitzbühel ETU Triathlon European Championships
21 Jun, 2014 - Women's PT1 - 01:25:26
Bill Chaffey's fourth Paratriathlon title is the sweetest
Paratriathlon continues to grow, and London played host to one of the most thrilling world championship races yet when Australia's Bill Chaffey claimed his fourth title in a frenetic…
Paratriathlete Takes Disability Sport Award
World Champion Jane Egan has rounded off an outstanding year in paratriathlon by winning the Disability Sport award at last night's Sunday Mail and sportscotland Sports Awards.
more articles tagged with Jane Egan →
Given Name Jane
Family Name Egan
Representing GBR
Jane's next event


Time for another contest and I like to get to the start line early (I was the first poster last time too ).
I'm not planning to start until around 15 September but by creating my contest thread now, I'm indicating to myself (and to the rest of the TT forum) my commitment to participate and kick some tail in burning some fat and getting fit.
I have a feeling....this is going to be a really good one!
Why are you going to start until the 15th????
It's presently the Ramadhan, the Muslim month of fasting, so it's difficult getting in the intense workouts and intervals needed (can't even drink water). The month ends on 10 September when there is a 3-day holiday to celebrate and then...it's down to business!
That really cool that you are fasting for Rhamadan.
There is this Vikings player (NFL) Husein Abdullah who has been fasting for Rhamadan through the entire training camp and preseason. He has played great and its pretty inspiring to see him out there on the field making plays knowing that he is fasting. I think Katie Couric did a story on him, but its been all over our local paper.
Much respect to you for your sacrifices.
Thanks for the comments and support. Interesting about the Vikings player...I'll try and read up some more about him. It's quite admirable being to do all that training and playing football whilst abstaining from food and drink.
The toughest part this year is not being able to drink anything - it's typically 42 deg C during the day!
I've decided to bring my start date forward so Day 1 will be 11 September (I always like to start on a Saturday so that I can finish on a Friday - that's my weekend here and so I'm almost always home and can get my wife to take my pics).
Good luck with your transformation this time, Waleed!! I'm sure you will manage to do the great change during this contest!! We are all here to give you all the support&advice you need!
Good luck, Waleed, and I am sure that you will have another successful transformation contest! My first year college roommate fasted during Ramadhan and it was quite challenging to juggle with school, but fortunately there was a strong community of Muslim students and special dining accommodations for that time which helped tremendously. I admire your dedication and wish you the best!
You can't out-train a bad diet.
To get something you've never had, you have to do something you've never done.
I've been at this a while-all last year in fact!
Thanks a lot Ion. I'm going to be sure to be more active in the forums this time - I always do better when I post my workouts and nutrition.


– XMLHttpRequest – an object allowing asynchronous transmission of data over the network. During processing the user can perform other tasks, also retrieve data from multiple sources.
– XML – markup language as data carrier of sent and/or received information. In addition to the XML also other formats are used, such as JSON, although the data carrier can also be plain text or HTML snippets. For the Ajax with JSON there is even a special term: AJAJ.
The send() method has one parameter: data appended to the query. This parameter must be used for the POST method. We use null if the method used is GET.
And here we go with the magic! It's time to operate on the document and perform changes without reloading the page.
We check the state by comparing the value.
This example shows how to parse XML simple structure that serves as an information carrier.
Let's see what the XMLHTTPRequest object hides.
The URL argument can be either relative or absolute address.
The "async" argument determines whether the request should be processed synchronously or not. For value of 1 (true) the script will continue work after the send() method call, for value of 0 (false) the script will be processed after receiving the response.
statusText – contains the status as a string (e.g. "Not Found" or "OK").
alert(cPublishers.length + " <pub:name/> elements found with "
AJAX is a very vast subject. Today it is ubiquitous, but I remember those times when this technology freshly became popular, and what impression could be done by the effects based on AJAX.
My favorite solutions are those offered by jQuery.
We strongly encourage you to follow the subsequent entries.


text:
British and Irish History: Biographies
Bruce, Edward
Bruce, Edward (d. 1318). Brother of Robert I king of Scots, earl of Carrick from 1313, titular king of Ireland (1315–18). Edward Bruce was an outstanding if savage soldier, but arrogant and over-ambitious. As soon as Robert I took the throne in 1306, Edward became one of his foremost commanders. In 1308 he ravaged Galloway, confining English authority in the area to a few castles, which were gradually reduced until 1313; further campaigns followed, culminating in the siege of Stirling castle which began in 1313. It is likely that a wearisome siege was not quite Edward's idea of war; and he made an agreement with the English commander Philip Mowbray that the castle would surrender if not relieved within a year. This meant that Edward II would have to attempt to relieve it, which displeased Robert I, since his policy was always to avoid a pitched battle and rely on guerrilla tactics. However, battle could not be avoided. At Bannockburn (24 June 1314), Edward was in command of the leading brigade. In August 1314, he was among the leaders of a raid into north-east England, which caused widespread damage. In the Parliament of 1315, he was rewarded by being made heir presumptive to the Scottish throne, in the (unlikely) event that Robert I would die without a direct male heir.
It seems that Edward was not satisfied, and felt that, while his brother was king, he could not achieve what he deserved in Scotland. With Robert's full backing, he embarked on an expedition to Ireland. He seems to have landed in Ulster at the end of May 1315, with the support of Ulster nobles, who had close links with Scotland; but then forced them to acknowledge him as king of Ireland, implying an intention to conquer the whole island. He proceeded to the south, ravaging as usual as he went; but did not find the support he expected. By October 1316, he wrote to the Welsh suggesting that he should join them in an attempt to expel the English from Wales, and that he should become prince of Wales as well as king of Ireland! There was so little reality in all this that in 1317, his brother had to come briefly to his aid in Ireland, but with little success. Edward's position as king was impossible to sustain; and in October 1318 he was killed in battle at Faughart, near Dundalk.
Bruce Webster
The Oxford Companion to British History JOHN CANNON
JOHN CANNON "Bruce, Edward ." The Oxford Companion to British History . . Encyclopedia.com. 14 Jan. 2020 <https://www.encyclopedia.com>.
JOHN CANNON "Bruce, Edward ." The Oxford Companion to British History . . Encyclopedia.com. (January 14, 2020). https://www.encyclopedia.com/history/encyclopedias-almanacs-transcripts-and-maps/bruce-edward
JOHN CANNON "Bruce, Edward ." The Oxford Companion to British History . . Retrieved January 14, 2020 from Encyclopedia.com: https://www.encyclopedia.com/history/encyclopedias-almanacs-transcripts-and-maps/bruce-edward
Edward Bruce. See Bruce, Edward.
JOHN CANNON "Edward Bruce ." The Oxford Companion to British History . . Encyclopedia.com. 14 Jan. 2020 <https://www.encyclopedia.com>.
JOHN CANNON "Edward Bruce ." The Oxford Companion to British History . . Encyclopedia.com. (January 14, 2020). https://www.encyclopedia.com/history/encyclopedias-almanacs-transcripts-and-maps/edward-bruce
JOHN CANNON "Edward Bruce ." The Oxford Companion to British History . . Retrieved January 14, 2020 from Encyclopedia.com: https://www.encyclopedia.com/history/encyclopedias-almanacs-transcripts-and-maps/edward-bruce
Roger de Mortimer 1st earl of March
Edward Bradford Titchener
Edward Braddock
Edward Bouverie Pusey
Edward Boscawen
Edward Bennett Williams
Edward Balliol
Edward Austin Sheldon
Edward Alsworth Ross
Edward Alexander Westermarck
Edward Alexander MacDowell
Edward Albert
Edward 3d duke of Buckingham Stafford
Edvard Hagerup Grieg
EDVAC
Educational Psychology Jobs
Educational Leadership Jobs
Educational discrimination
Edward Bulwer Lytton Baron Lytton
Edward Calvin Kendall
Edward Chace Tolman
Edward Channing
Edward Charles Pickering
Edward Crisp Bullard
Edward de Vere
Edward Douglass White
Edward Drinker Cope
Edward duke of York
Edward Durell Stone
Edward Earl of Clarendon Hyde
Edward Edwards
Edward Eggleston
Edward Emerson Barnard
Edward Evan Evans-Pritchard
Edward Everett
Edward Eyre
Edward Fairfax
Edward Forbes
Edward Frankland
Edward Franklin Frazier


Dr. Diamos received her doctorate of optometry degree from Southern California College of Optometry and returned to her native Tucson to open her practice which offers eye exams, contacts, low vision services in Tucson. She has been a practicing optometrist here in Tucson for over 25 years. She is board certified by the American Board of Optometry.
She is certified in the treatment and management of eye diseases, fitting of specialty contact lenses and treatment and management of dry eye disease.


Heel pain is common and can be due to a number of conditions. The calcaneus (heel bone) is the largest bone in the foot and is the first to hit the ground when walking. The heel bone is designed to be the first contact the foot has with the ground. The achilles tendon inserts into the back of the heel bone (calcaneus) and a very strong ligament along the bottom of the foot attaches to the bottom of the heel bone (the plantar fascia). Several small muscles also attach to the heel bone above the insertion of the plantar fascia. Given the forces of walking that the heel bone is subjected to and the pull of all these ligaments and muscles, then it is not surprising that Heel Pain is so common.
What Should I Do About Achilles Tendinitis Discomfort ?