text:
Q: Ubuntu 14.04 Display Freezes Occasionally I recently installed Ubuntu 14.04. I have an NVIDIA GeForce GT 540M (1GB) graphics card, and I noticed the open source Nouveau display driver was returning error code -16 on suspend, causing the computer to immediately rewake. So I switched over to the proprietary, tested NVIDIA v331.38 driver.
This fixed the suspend problem, but now the display will occassionally freeze and stop accepting input. The computer itself doesn't freeze -- audio keeps playing and touchpad input still goes through.
For some reason, when I switch over to the terminal using Ctrl+Alt+F1 and then switch back with Ctrl+Alt+F7, the display unfreezes and everything's fine until the next freeze.
It seems the freezing happens more often if I'm using my touchpad more actively. It's only brought on by a touchpad input as well. It won't freeze on its own.

A: By any chance, are you using a touch pad? If so, changing the touch pad to work as a normal usb mouse will correct issues with a 'unresponsive screen.' Unfortunately, you will not be allowed to use the tap to click feature or scroll using the pad.

A: This is a known bug. Fortunately, there is a fix now (but you'll need to compile packages yourself). See https://bugs.launchpad.net/ubuntu/+source/nvidia-prime/+bug/1220426.

A: Check the additional drivers on control panel > Software & Updates. Choose the proprietary driver.
After, enter on terminal (Ctrl + Alt + T) and perform:
sudo depmod nouveau
sudo rmmod nouveau
sudo update-initramfs

Reboot the system.

A: I had a very similar issue with my 14.04 install. It would freeze for seemingly no particular reason. I blamed various pieces of software before realising it was the graphics drivers.
This post I found really useful in starting me on my journey to actually having working nvidia drivers.
How do I install the Nvidia driver for a GeForce GT 630

A: I resolved the problem by switching over to the legacy driver - version 304.117 from nvidia-304-updates.

A: the following three BiOS settings ( 3 CMOS settings ) fixed it for
my ASUS M2N MX SE PLUS motherboard with
 AMD Athlon® 64-bit 2-core CPU 4200+
( and with NViDiA GeForce 6150SE graphics chip:)

❶   CPU clock = 200 MHz "manual" ( Not "Auto"; not "Limit" )
❷   4 GB RAM clock = 200 MHz "manual" ( Not "Auto"; not "Limit" )
❸   PCi express clock = 100 MHz "manual" ( Not "Auto"; not "Limit" )

with above setting, AMD 64-bit 2-core CPU runs at 2.21 GHz speed ( else if the BiOS CMOS setting is
either "Auto"
or "Limit = 250 MHz"  or  "Limit = 275 MHz"
then it may be randomly varying the clock speeds during run-time i guess ( also known as Spread-Spectrum-Clocking...


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We are responding to the letter you made available to the public. First, we want to say we are in total agreement with you regarding the great number of professional, dedicated officers on the Boston Police Department. This is the only thing The Massachusetts Association of Minority Law Enforcement Officers can agree with you on. We were extremely surprise to see the leader of the Capital city police department resort to Facebook and Twitter to deliver his message. First, let me start by disputing your assertion that few minority candidates are at the top of the civil service list.
In October of 2008 you had an opportunity to promote (2) African-American Sergeants and a white-female (Sgt. Det. Robert Tinker, Sgt. John Johnson Sgt. Christine McKenna) who wore tied atop of the civil service list, but you failed to do, hence allowing them to remain sergeants. You instead promoted two white-males to the rank of Lieutenant. Civil Service did not hamper you then.
In June 2013 again you had an opportunity to name an African-American Lieutenant to the rank of Captain, but again you decided to go with your gut and promote a white male to the position of Acting Captain. Civil Service did not hamper you then either. Commissioner Davis you've talked plenty about the Department's commitment to diversity, but yet we think the public should judge you on your body of work. As recent as last month (August 2013) you thought it would be a great idea to promote 4 white-males and 1 white-female to the rank of Sergeant even though there were nine officers of color with exactly the same mark on atop the Civil Service list. You promoted 2 African-American Sergeants only and after you were confronted by the Herald, City Councilors Ross, Yancey and MAMLEO. Again, Civil Service did not hamper you.
In reference to the upcoming Civil Service Promotional Exam slated for June of 2014. Commissioner Davis, we urge you not to invoke minority officers as a reason you are trying to "fast track" an exam that will be subjective in nature and will only lead to more nepotism in a department riddled with it. MAMLEO, alike all the unions, oppose the make-up of the exam you are trying to introduce. We prefer that the next exam be devised by the incoming administration.
According to BPD statistics (which we have attached) 35% of the patrol force is minority and 65% is white, while the latest City of Boston Census available illustrate that 53% of the city is minority and 47% white.
You tout your command staff as being 42% people of color and also appointing the first Hispanic Captain. In setting the record straight you did not appoint Alfredo Andres Captain; he attained that rank through hard work. As far as appointing Deputies which you do have the authority to do, we agree you have done so, but they are all Assistant Bureau Chiefs. Your administration, much like Mayor Menino's, does not have anyone of color as a Bureau Chief. All the Deputies you tout do not command their respective Bureaus. The only Superintendent you have appointed is William Gross and he is a night-superintendent who is extremely popular with the troops and the community.
As far as appointments to district stations and specialized units, you bring up a great topic of discussion. Since coming to the BPD from Lowell PD we've been trying to get your attention regarding the segregation of certain districts like D-4 (South End) and E-13 (Jamaica Plain). The South End has approximately 130 officers assigned to it with less than 2% minority, while Jamaica Plain is the complete opposite comprised of mostly Hispanic officers. MAMLEO hardly believes this to be a coincidence.
Commissioner Davis you describe how you continually appoint "qualified" minority officers to specialized units. Really? The Drug Control Unit reads as follow: 69% White, 20% Black, 10% Hispanic and 1% Asian. The Gang Unit is 64% White, 26% Black, 10% Hispanic and 0% Asian. The Homicide Unit is 64 White, 22% Black, 14 Hispanic and 0% Asian.
If these numbers do not grip you Commissioner may we also add that there less than 5% minority supervisors in all the aforementioned units. There is 1 supervisor of color in the Gang Unit and it took an eternity to accomplish. While the Drug Unit boasts 1 Hispanic supervisor, 2 black supervisors and 0 Asian supervisors. Female supervisors and patrol officers in specialized units are almost non-existent.
Lastly, Commissioner Davis we'd like to point out that MAMLEO has been trying to get your attention since 2007 to no avail. We have been part of your now defunct "Diversity Council" which has not met in in approximately 9 months. You call this a commitment to diversity and equality? We have asked on numerous occasions to have a seat at the table without much success. If anyone needs to take ownership of the divisiveness it is you Commissioner. Your lack of vision and progressiveness should not be condoned by OUR community, let alone by our nation.
As for Mr. Marvin Miller's article in the Bay State Banner you really have to take into consideration the source. Mr. Miller was given a $200k loan by Mayor Menino in July of 2009 which some have estimated it has reached $350,000. Which begs the question, who wrote the article anyways?
MAMLEO continues to provide civil service entry level and promotional test prep training, karate school for kids and youth enrichment programs such anti-bullying and gang prevention just to name a few. We continue to have our summer youth outing, turkey handouts during Thanksgiving and toys during the Holiday season. What has Mr. Miller done for his community lately?
Commissioner in closing, I would just like to say that our organization would have loved a working-relationship with your administration, but from day one you made it clear you were going to treat minority officers in Boston the same way you treated them Lowell. We don't think MAMLEO is part of the problem as you suggest, but whole heartedly we insist MAMLEO is part of the solution. One can't lead if he is not allowed to do so. MAMLEO has been and will continue to be the fabric and glue that holds the minority community together.
On behalf of all MAMLEO members and our partners in the community we hope this conversation may continue under a different forum.


text:
package com.infinityraider.infinitylib.utility.inventory;

import net.minecraft.world.WorldlyContainer;
import net.minecraft.world.item.ItemStack;

import javax.annotation.Nonnull;

/**
 * IInventory shares an MCP-mapped method with IItemHandler: getStackInSlot(int index)
 * Classes implementing both interfaces will have the implementation of this method obfuscated for IInventory,
 * effectively removing also the IItemHandler implementation.
 *
 * This will lead to AbstractMethodExceptions, therefore this wrapper interface has been created.
 *
 * It is ugly, I know
 */
public interface IWorldlyContainerWrapped extends WorldlyContainer {
    @Nonnull
    @Override
    default ItemStack getItem(int index) {
        return this.getStackInInvSlot(index);
    }

    ItemStack getStackInInvSlot(int index);
}

redpajama_set_name: RedPajamaGithub


This entry was posted on February 12, 2017, 3:21 pm and is filed under scorecards, stats. You can follow any responses to this entry through RSS 2.0. You can leave a response, or trackback from your own site.
Interesting topic. I have been tempted to investigate.
I think I found the answer to where this blasted stat was derived! It's in the first few pages of that information theory book you linked to which is available on Google, in the section on Divergence – this is what would apparently now be called symmetric kullback-leibler divergence according to wikipedia.
Lets say we're doing WOE/IV on age binning and I will summarize my possibly incorrect understanding. We have our distributions b(age) and g(age) which give the probability that a sample falls in a given age bucket given that they are bad or good respectively.
We start with the Bayes Rule that tells us that LogOdds(Bad:Good given Age) – LogOdds(Bad:Good) = WOE(bad), i.e. your WOE(bad)=log(b(age)/g(age)) gives you a measure of how much you are increasing or decreasing your log odds that the sample is bad when you take into account age vs. when you don't. WOE(good) is just negative WOE(bad).
The KL(Bad, Good) divergence is the expected WOE(bad), i.e. average change in log-odds by taking into account age, for samples that are actually bad. It's always positive because on average bad samples are going to be in age buckets where bad is concentrated more than good is concentrated i.e. they end up in buckets with positive WOE, This is intuitively satisfying as well because on average adding data such as age vs. not adding should only ever increase the log-odds in favour of bad for samples that are actually bad, suggesting positive average WOE again. So KL(Bad, Good) is used as a measure of information gained (discriminative power gained) by taking into account age for bad samples.
Symmetric KL is KL(Bad, Good) + KL(Good, Bad), it's the information gained for samples which are in fact bad plus information gained for samples which are in fact good. It can be written in the form sum((g(age)-b(age))log(g(age)/b(age))) i.e. it is the IV stat.
What a great comment – it looks like you've nailed it! Thank you very much.
The bounded-ness of total information is relevant for "Information Value", KL grows with sample size whereas WoE is just a log of the ratio.
Using the IV criterion will emphasise explaining mid-range probabilities over fitting the tails – for credit worthiness this might not be ideal. This effect is similar to Logistic Regression which also has an underlying robustness and is good at classification, focusing attention on fitting the marginal cases.
If you want to pay more attention to fitting tails to observed data you could stratify the sample or you could use a different link function in your regression – e.g. "probit".
Very interesting, thank you for your comment!


text:
All about hypnosis
Hypnosis for mental health problems
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How many hypnosis sessions are needed for anxiety?
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Crying during hypnosis should not be a cause to worry. It reveals a release of tension and built-in emotion, which is always good to release to access other emotions and facilitate personal growth. Rather than stopping yourself from crying, feel through these emotions to the end, for a crucial realization.
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In hypnosis there is often a reddening of the eyes. Though not observable outwardly, a person in trance often reports fogging or blurring of the vision. Hypnosis can also cause tunnel vision, or even changes in the colors, sizes, and shapes of things. A person in hypnosis will be less distracted by outside sounds.
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As long as you're seeing a licensed mental health professional who has extensive training in hypnosis, the use of hypnotherapy to treat anxiety is considered very safe.
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redpajama_set_name: RedPajamaCommonCrawl


04.23 The cautious seldom err.
In James Legge (trans.), 'The Confucian Analects', The Chinese Classics: Life and Teachings of Confucius (1861), Vol. 1, Book 4: Le Jin, Chap. 23, 35.
Discoveries that are anticipated are seldom the most valuable. … It's the scientist free to pilot his vessel across hidden shoals into open seas who gives the best value.
From 'Why Our Scientific Discoveries Need to Surprise Us', in The Globe and Mail (1 Oct 2011).
Good people are seldom fully recognised during their lifetimes, and here, there are serious problems of corruption. One day it will be realised that my findings should have been acknowledged.
It was difficult, but she always smiled when asked why she went on when recognition eluded her in her own country.
Quoted in obituary by Anthony Tucker, 'Alice Stewart', The Guardian newspaper (28 Jun 2002).
In 'The Growth of the Steam-Engine', The Popular Science Monthly (Nov 1877), 17.
Mathematicians go mad, and cashiers; but creative artists very seldom. I am not, as will be seen, in any sense attacking logic: I only say that the danger does lie in logic, not in imagination.
'Of Nature in Men' (1625) In James Spedding, Robert Ellis and Douglas Heath (eds.), The Works of Francis Bacon (1887-190I), Vol. 6, 469.
In The Art of Doing Science and Engineering: Learning to Learn (1975, 2005), 5.
Rules can seldom be safely applied without a clear understanding of the principles on which they rest.
From Field-Book for Railroad Engineers (1854), Preface, vii.
Science seldom renders men amiable; women, never.
Attributed, but not verified. Found with this wording in quote collections at least as early as Notable Thoughts about Women: A Literary Mosaic (1882), 28. This and various later quote collections, almost never give the source. Cited as from Maximes, Réflexions et Pensées Diverses by Alan L. Mackay, A Dictionary of Scientific Quotations (1991), 24, but without identifying the specific page. Webmaster has not be able to identify within that book, when looking for a close match in the original French in the 3rd edition (1819) chapters on Women and on Science. (Other editions were not checked). If you can help improve this citation, please contact Webmaster.


text:
Cyprian Michael Iwene Tansi , OCSO (September 1903 – 20 January 1964) was an Igbo Nigerian priest of the Catholic Church who worked in the Archdiocese of Onitsha, Nigeria, and then became a Trappist monk at Mount Saint Bernard Monastery in England.

On 22 March 1998, upon the recommendation of Cardinal Francis Arinze, he was beatified by Pope John Paul II.

His feast day is 20 January.

Heritage and early life
Tansi was born in September 1903, in an area of Nigeria under the control of the Royal Niger Company (RNC). The RNC maintained a trading outpost in Aguleri, purchasing palm oil from local farmers to sell abroad. An incident happened when a local person named Onwurume wanted to take a little palm oil to put on his roasted yam (yam is the staple food of Igbo people, and palm oil to yams is the cultural equivalent of butter to bread) and decided to puncture a barrel of palm oil to get some. When the hole he made caused the entire barrel to be emptied out, he ran away, but was grabbed by employees of the company and put into custody. When the local people heard about it, they gathered together to negotiate with the company agents, but the company called for military reinforcements and arrested twelve village chiefs who came to negotiate. Afterwards, they proceeded to attack the neighbouring villages, burning down the homes of the local people and looting their property, as well as mistakenly destroying a nearby village of a different group that had no relation to the incident.

Michael's father was Tabansi of Igbezunu, Aguleri. He was one of the people taken hostage by the Royal Niger Company and later released.  Michael was his first born, and he had another son with his first wife. Later he named his firstborn son 'Iwe-egbune', shortened to Iwene, meaning 'let malice not kill'; this was the birth-name of Cyprian Michael Iwene Tansi. His parents were poor farmers; they were not Christian. After the death of his first wife, Iwene's father married again. He and his second wife had four boys and one girl.

When Iwene was a young child, he became permanently blinded in one eye as a result of a mud-fight with other children.

His father sent Iwene to Holy Trinity School in Onitsha, which was run by the Holy Ghost Fathers. Tabansi meant for his son to get a better education that would help lead their family out of poverty, so that they would never again be taken advantage of by the westerners. Michael was baptized on July 7, 1913 with the Christian name of Michael. At the school, Michael served as an altar boy and catechist. Upon graduating, he became a teacher, and worked as a teacher from 1919-1925, Later, he became headmaster at St. Joseph's school in Aguleri.

Seminarian
At that time, there was little enthusiasm among Blacks to become priests in Nigeria. The Bishop was Irish, and most of the clergy were Europeans. Bishop Shanahan saw the native Igbo, even after conversion, as still being steeped in paganism, and that it was going to be difficult to teach them to be proper priests. While Igbo could become priests, they were subject to strict discipline and were often expelled from seminary for relatively minor lapses. The priests who taught them were concerned that only the very best men should become priests.

Michael attended St. Paul Seminary in Igbariam from 1925-1937. His family was appalled at his entrance to the seminary, because they wanted him to go into business or something that would take them out of poverty, which was what his father had always planned. His family was poor and desperately needed his help, but he felt that God, the same God he had learned about in the mission school his parents had sent him to as a child as a means of getting material benefits for the family, wanted him to continue in the seminary rather than do something else. There, he developed a particular devotion to the Sacred Heart of Jesus and to the Blessed Virgin Mary.

Parish priest
At that time in Nigeria, almost all priests were foreign missionaries.  Few Africans were being ordained to the priesthood. Tansi was ordained a priest for the Archdiocese of Onitsha at the Cathedral Basilica of the Most Holy Trinity in Onitsha on December 19, 1937.

As Black priests became more common, some followed the lifestyle of the foreign missionaries. Monks and nuns also lived more comfortably than most Nigerians, and some people began looking at taking holy orders as a priest, monk or nun as a way to escape poverty.

When he became a parish priest, he lived a very austere life in comparison to the other priests around him. He built his own home using adobe, mud brick or other traditional materials. He would sleep on any bed, even if it was uncomfortable. He would eat even poorer food than what the local people ate, surviving on tiny portions of yam. He sometimes had a motorbike provided to him, but he often preferred to use a bicycle or even just to walk. He was not deterred from doing his work by tropical rainstorms.

His lifestyle shocked the Nigerian Catholics, who were not accustomed to this kind of priest. He became extremely popular and loved among the four parishes that he served in: Nnewi, Dunukofia, Akpu/Ajalli, and his home town Aguleri. He organized the community to help the poor and needy, and he personally would help people to build their own homes or perform other projects. He was very good at building homes, and taught people new building techniques, with adobe or mud brick, that were copied and used by the whole community. He was remembered as always being very kind.

He also stood up against oppression of women within the traditional culture and advised women to fight back against those who would rape or mistreat them. On one occasion, a female parishioner was attacked by a group of males, and she fought back against them. Fr Michael, who was nearby, came on his bicycle and joined with her and fought them until they fled. He then encouraged her to bring the assailants to court, which she did, winning the case against them and forcing them each to pay her four pounds; this case was a milestone in the establishment of women's rights in Nigeria.

He was unyielding in confronting vice among his flock. He had a special interest in preparing young women for marriage. With the help of local nuns, the women were taught about Christian marriage and how to care for the children they would have. He would organize the community to place the bride to be in a special home wherein she would be looked after until she got married. He would not allow men to see their brides before they got married, and if the groom attempted to go there without Fr. Tansi's permission, he could be penalized. He also had a women's group organized, who would enforce disciplines on their own members to avoid premarital sex and deter abortion.  He was also a very strict disciplinarian with students who failed to work hard at the parish school, to the point of hiding near the school, waiting for the bell to ring, and then, when he saw students coming late, coming out of his hiding place and penalising them for coming late to school.

He also was opposed to some aspects of the traditional pagan culture in Nigeria, especially the masquerades, who were believed to be spirits and used to punish innocent people at times. Nigerian pagans had murdered his own mother after claiming she was a witch who had caused mischief.

He gave the community advice and teachings about the right way to live in a practical fashion. For example, there were many mango trees in his locale, and it was common for people to go to the trees and throw rocks at the fruit. In the process, they would knock down far more than they were going to eat, or knock down the unripe fruit along with the ripened fruit, thus denuding the tree before the season was over. Michael considered this very wasteful, and told his parishioners to pluck each mango individually so that nothing was wasted and that they would not lack mangoes to eat later.

He was also remembered as being a perfectionist, which sometimes caused resentment among those under him. Later, his experience as a novice monk would give him insight into his earlier strict methods.

Trappist monk

While serving in his last parish, in his own hometown of Aguleri from 1949-1950, Michael began to become attracted to the monastic life. At that time, there were no monasteries established in Nigeria, and the Bishop was interested in the idea of sending some candidates to a monastery in Europe who would become monks in Europe and later return to Nigeria to start up the first Nigerian monastery. Michael and others were selected for this project.

1950 was a jubilee year in the church, and Michael was first sent to Rome to make the pilgrimage to the four major basilicas. He was then sent to Mount St. Bernard in England, to join the Trappist monks there. He arrived on 8 June 1950.

At the monastery, he joined the novitiate and took his vows, taking the name Cyprian after the Roman martyr. Cyprian worked in the refectory and bookbindery, and in the vegetable gardens and orchard. He used to say, "If you are going to be a Christian at all, you might as well live entirely for God". Father Anselm Stark, who knew Fr Cyprian, recalled: "As a person he was very ordinary, very humble, obviously a great man of deep prayer and dedication."

Cyprian was sensitive to criticism, and his novice master was very hard on the new monks, and could always find things that were wrong with what he had done. This caused him much stress, and it was during this trying time that he understood that he had made some mistakes in Nigeria with the hard discipline and expectations he had placed on those under him. Despite fears of being treated with racial prejudice, he was fully accepted by the other monks, with the exception perhaps of one South African monk, who seemed to look for things to find wrong in his work. The English winter was also hard on him.

He was commissioned to establish a monastery not in Nigeria, but in neighboring Cameroon, but ill health changed those plans. He did not feel that the Nigeria independence movement had been properly done.  His health deteriorated, but he accepted death with no complaint. Before he died, he went to Leicester Royal Hospital, and, when he was examined, the doctor came out of the examination and spoke with monastery priest Fr. James, saying: "Can you help me please, Father? This man must be in terrific pain, but he will only admit that he has 'a little pain.'" He died the same day, as a result of arteriosclerosis and a ruptured aneurysm. The date of his death was 20 January 1964.

His body was buried at the monastery in England, but was later interred at the Cathedral Basilica of the Most Holy Trinity, Onitsha, Nigeria.

Quotations

 "Count no one saved, until he is found in heaven" (Onye afuro na enuigwe, si aguyi na)
 "Do not be imitating the whites in everything, strive hard to gain the Kingdom of God. The whites are already in heaven in this world, but you are suffering every want. Are you going to suffer also in the next world: Life on earth could be compared to the journey of a young student who received a slip for a registered parcel, and he had to go to Lagos to claim this parcel. On the way he passed through many beautiful towns, towns with very attractive things in the shops. He started going from one shop to another, stretching his hands to the beautiful things he saw. He stopped so often in these big towns that he almost forgot what he was travelling for. It was after a long time that he ultimately reached Lagos, and when he went to claim the parcel he was told that the parcel had lain in the post for so long without him arriving to claim it that they had finally decided to send it back to the sender."

 "God will give you double for what you give Him"

 "If you want to eat vultures, you may as well eat seven of them, so that when people call you "vulture eater" you really deserve the name. If you want to become a Catholic, live as a faithful Catholic, so that when people see you, they know that you are a Catholic. If you are going to be a Christian at all, you might as well live entirely for God."

 "Whether you like it or not, saving your soul is your own business. If you are weak and fall by the wayside, we shall push you aside and tread on you as we march forward to meet God."

 "She is not 'Onye Bem' (a common Nigerian expression for wife, meaning 'in my place) but your wife, your better half, part of your own body. 'Onye' means a stranger which your wife is not. You must recognize the worth and position of your wife and treat her as your partner and your equal. Unless you do that, she is not a wife to you but a servant, and that is not what God wants a wife to be to the husband."

Veneration
He was recommended by Cardinal Francis Arinze, who was inspired by Tansi as a boy when Tansi had been one of his teachers.

He was beatified by Pope John Paul II on 22 March 1998, at Oba, Nigeria, becoming the first West African to be beatified. Pope John Paul said: "Blessed Cyprian Michael Tansi is a prime example of the fruits of holiness which have grown and matured in the Church in Nigeria since the Gospel was first preached in this land. He received the gift of faith through the efforts of the missionaries, and, taking the Christian way of life as his own, he made it truly African and Nigerian."

There is a statue of Father Tansi outside Most Holy Trinity Basilica in Onitsha. In 2010, Michael Cyprian Iwene Tansi was named a patron of Nigerian priests. Archbishop Valerian Okeke compared Father Tansi to St John Mary Vianney as a model of sanctity.

Institutions Named after Blessed Cyprian Iwene Tansi
 Blessed Iwene Tansi Major Seminary, Onitsha Anambra State Nigeria (Provincial Seminary)
 Blessed Iwene Tansi Secondary School, Aguleri
 Blessed Iwene Tansi Parish, Umudioka
Blessed Iwene Tansi Parish, Awada-Onitsha
Blessed Iwene Tansi Parish, Mba Farm, Onitsha
 Blessed Iwene Tansi Parish, Ugwu Orji Owerri Imo State
 Blessed Iwene Tansi Parish, Transekulu, Enugu State
 Blessed Iwene Tansi Chaplaincy, Nike Grammar School, Enugu State
 Blessed Iwene Tansi Chaplaincy, Chukwuemeka Odumegwu Ojukwu University (Igbariam Campus)
 Tansi International College Awka
 Tansian University, Umunya
 Blessed Michael Tansi Catholic Church, Aba

References

External links
Publications on Blessed Iwene Tansi
Early history

1903 births
1964 deaths
Nigerian beatified people
Nigerian emigrants to the United Kingdom
Nigerian Roman Catholic priests
Igbo theologians
Trappists
20th-century venerated Christians
People from colonial Nigeria
People from Anambra State
Venerated Catholics by Pope John Paul II
20th-century Nigerian people
Trappist beatified people
20th-century Roman Catholic priests

redpajama_set_name: RedPajamaWikipedia


text:
Queen Elizabeth II turns 88; David Bailey royal pic released
By Marcus Hondro Apr 21, 2014 in World
Queen Elizabeth II turns 88 today, April 21, and the occasion has been marked by a new photograph. The Royal Family released the portrait on their Twitter site the day before her big day and it shows a smiling and, naturally, dignified-looking woman.
The portrait is viewable on the Buckingham Palace website and @britishmonarchy; it was taken by renown British photographer, David Bailey.
The Queen has had multiple photographic portraits taken during her reign, which started when she was 25 in February of 1952, over 62 years ago. The mother of two has soldiered on through family deaths and divorces and the changing face of the U.K. and the world. She is the longest-lived British Royal monarch and if she continues as Queen for another 155 days will surpass Queen Victoria's reign to become the longest reigning monarch.
"I've always been a huge fan of the Queen," Mr. Bailey told the BBC. "She has very kind eyes with a mischievous glint. I've always liked strong women, and she is a very strong woman."
A portrait of Queen Elizabeth II by famous British photographer David Bailey was unveiled by Buckingham Palace to mark the monarch's 88th birthday
David Bailey / Buckingham Palace
More about Queen elizabeth II, Queen Elizabeth II royal portrait, david bailey
Queen elizabeth II Queen Elizabeth II r... david bailey


text:
Historical Adventure
The Himalayan Codex : An R. J. Maccready Novel
3.5 (300 ratings by Goodreads)
R. J. MacCready
By (author) Bill Schutt , By (author) J R Finch
Looks like Schutt and Finch are filling the void left by the passing of Michael Crichton.--James Cameron, director/writer/explorer
In the wake of World War II, zoologist and adventurer Captain R. J. MacCready is sent to the frozen mountain valleys of Tibet to find a creature of legend that may hold the secret to humankind's evolutionary future--or the key to its extinction--in this explosive follow-up to Hell's Gate.
It is 1946, and the world is beginning to rebuild from the ashes of the devastating war. Marked by the perilous discoveries he encountered in the wilds of Brazil, Captain R. J. MacCready has a new assignment on the other side of the globe--a mission that may help him put the jungle's horrors behind him. He is headed for the Himalayas, to examine some recently discovered mammoth bones.
Arriving in Asia, Mac learns the bones are only a cover story. He's really there to investigate an ancient codex allegedly written by Pliny the Elder, a fascinating text filled with explosive secrets. The Roman naturalist claimed to have discovered a new race of humans, a divergent species that inspired the myth of the Yeti and is rumored to have the ability to accelerate the process of evolution. If Pliny's assertions are true, this seemingly supernatural ability holds unlimited potential benefits--and unlimited potential for destruction.
Charged with uncovering more about this miracle species, Mac sets off into the remote mountain valleys of Tibet, using the codex as his guide. But the freezing climate and treacherous terrain are only the beginning of the dangers facing him. He must also contend with the brutal Chinese army and a species of native creature even the Yeti seem to fear. The deeper he plunges into the unknown, the more certain it appears that Mac and the associates who join his odyssey may not make it out alive.
Combining plausible science, history, and action-packed thrills, The Himalayan Codex is a page-turning adventure sure to enthrall fans of James Rollins, Michael Crichton, Dan Brown, and Douglas Preston and Lincoln Child.
Dimensions 152 x 229 x 32mm | 540g
Publication date 06 Jun 2017
Publisher William Morrow & Company
Illustrations note Illustrations, unspecified
Bestsellers rank 2,332,693
The Darwin Strain
Bill Schutt
In the wake of World War II, military hero, zoologist, and adventurer Captain R. J. MacCready is sent to the frozen mountain valleys of Tibet to find a creature of legend that may hold the secret of humankind's evolutionary future--or the key to its extinction--in this explosive follow-up to Hell's Gate
It is 1946, and the world is beginning to rebuild itself from the ashes of the devastating war. Marked by the perilous discoveries he encountered in the wilds of Brazil, R. J. MacCready has a new assignment on the other side of the globe. He is headed for the Himalayas to examine some recently discovered mammoth bones--a mission that may help him put the jungle's horrors and the loss of his friend and colleague Bob Thorne behind him.
Arriving in Asia with the bright and fearless Yanni Thorne, his friend's widow and now his invaluable assistant, Mac learns the bones are only a cover story. He's actually been sent there to investigate an ancient codex allegedly written by Pliny the Elder, a fascinating text filled with revelatory secrets. The Roman naturalist claimed to have discovered a new race of humans, a divergent species that inspired the myth of the Yeti and is rumored to have the ability to accelerate the process of evolution. If Pliny's assertions are true, this seemingly supernatural ability holds unlimited potential for human progress--and unlimited potential for destruction.
Charged with uncovering more about this miracle species, Mac sets off into the remote mountain valleys of Tibet, known to the locals as the Labyrinth, using the codex as his guide. As he plunges deeper into the unknown, he realizes that the freezing climate and treacherous terrain are only the beginning of the dangers ahead. Working against the clock--American intelligence believes a communist take-over of the region is imminent--Mac must contend with the brutality of the encroaching Chinese army and a mysterious and threatening species of native creatures. The farther ahead he forges on this mission, the more certain it appears that Mac and the associates who join his odyssey may not make it out alive.
Combining plausible science, riveting history, and action-packed twists, The Himalayan Codex is a page-turning thrill ride from two of the top adventure writers working today.
"This one pushes the envelope to the edge and beyond, with tension and imagination that crackles from the first page. A terrific story, terrifically told. So take a walk on the perilous side, if you dare."--Steve Berry, New York Times bestselling author of The 14th Colony on Hell's Gate
5 20% (61)
3 37% (110)
1 3% (9)


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Q: PHPenv install not working? I am trying to test phpenv.
I have cloned the repo and set the paths, but when I try to perform
$ phpenv install php-5.3.20

I just get a
phpenv v0.0.4-dev
$

Shouldn't this command add an entry under the ~/.phpenv/versions ?

A: I realize that this is an old post, but I was having the same problem now, and I solved it by installing php-build (check Use with phpenv) and then running phpenv install 5.5.21. Then I got errors for missing dependencies, so I installed the below and reran the installation

sudo apt-get install build-essential libxml2 libxml2-dev
sudo apt-get build-dep php5-cli
sudo apt-get install libcurl4-openssl-dev libmcrypt-dev libreadline-dev
phpenv install 5.5.21

but now 45 mins after the phpenv install, it's still stuck on [Compiling]: /tmp/php-build/source/5.5.21.

A: Try to checkout to master branch if you currently are in dev. It helped me.
Additional information you can find here: https://github.com/phpenv/phpenv/issues/19

redpajama_set_name: RedPajamaStackExchange


19...use blue color scheme of our brand. Just need a professional upgrade of deck, limited creative input. Have a budget of $265. Need samples by tomorrow of how you would upgrade, I can send you 5 pages or so of current deck. Draft emailed to me by no later than Friday. Need answer today before close of business. In Atlanta prefer a local freelancer.


Have you ever thought about drinking alcohol in space? We're not talking about a champagne supernova in the sky, either. Yeah, not that crappy Oasis song, we're talking about a real-life thing involving outer space and also alcohol—astronauts brewing and drinking beer in space.
Why Are They Making Alcohol in Space?
As we know, alcohol has greatly influenced science and the modern age. What better way to treat our scientists than to give them alcohol?
No, really. That's kind of the whole point of this experiment.
In the somewhat near future, a trip to Mars will happen. When the time comes, we'll need some way of providing the astronauts with their earthly vices. So, Anheuser-Busch is sponsoring research on the International Space Station with the aim of learning how to make beer brewing in space a possibility.
The real challenge of this mission comes with planting their own crops to produce beer. Wheat and other beerly things will have to be homegrown—or spaceship-grown.
This will prove to be quite a challenge, since astronauts haven't exactly perfected outer space farming, let alone making alcohol in space. They'll actually need a space about the size of a car to plant the crops they need to brew enough beer for the astronauts aboard. So, imagine the challenge of providing beer to the Mars colony when the time comes.
The space required for this step involves almost as much as the farming itself. You need room to douse the plant with yeast in order for it to convert the sugar into ethanol. Also, that's an issue, dousing things—there's not really any gravity.
Obviously, since we're dealing with yeast, gravity is vital. The astronauts will likely have to put the components into a special chamber that spins them to create centripetal force, stabilizing the ingredients enough to do their thing.
Then comes the distillation. In distillers, the water and alcohol are somewhat mixed, but alcohol has a lower boiling point than water. So what happens is that the components are boiled at just the right temperature so that the alcohol separates and turns into vapor, where it enters a cooling chamber, and then drips into a different place where alcohol now is. Cool.
Yeah, that doesn't work in space.
Apparently, Plan B involves the very vacuum of space that makes things difficult in the first place. Without getting all scientific, the plan is to use that pressure difference to perform reverse osmosis. When the alcohol and water are still in their solution, reverse osmosis allows them to separate without having to take all those other steps.
It's really simple, actually: the alcohol/water solution is in one container, and then the pressure is introduced and boom… the alcohol is separated and thrust into the adjacent container.
Where Else Can You Get Alcohol?
Making alcohol in space sounds hard, but right here in DTLV, you can get the finest normally distilled and fermented spirits without all the weird physics stuff involved. We don't have the International Space Station, but we do have specialty tours at Vegas Pub Crawler, so book yours today!


NEVER FLOODED! Beautifully updated home nestled in a heavily wooded, low-traffic lot in the community of Fairwood in Cypress, TX! This home features a completely updated open kitchen with granite counters, stone accents, stainless appliances, and more! New wood-like tile floors installed throughout the entire home. A beautiful stone fireplace with floor to ceiling stone, mantle, and hearth highlights the huge, open family room. Master bathroom has granite counters with dual custom sinks and a huge walk-in shower. Great Cy-Fair schools!
Back Yard. Subdivision, Concrete Road, Wooded.
I am interested in 15030 Cypress Falls Drive, Cypress, TX 77429.


In an untamed world riddled with untamed hate and violence, it is powerful and comforting to know there is an Untamed Love born of the heart of an Untamed God. Through these very personal stories, you will find yourself drawn into experiences of the extravagant Love of a very Wild God. God is untamed —God never holds back. God is always with us, waiting and wanting to help us through life's untamed moments.


text:
Alien plants and animals drive native species to extinction
by University of Adelaide
Accidentally or deliberately introduced species are the second most common threat associated with recent global extinctions of animals and plants, a new study from the University of Adelaide and UCL, in the UK, has found.
These 'alien species' have spread beyond their natural distributions by both deliberate and accidental human intervention since transnational shipping started in 1500AD─and many have significant negative environmental impacts.
The study published in the journal Biology Letters assessed how common alien species were listed as drivers of recent extinctions in plants, amphibians, reptiles, birds, mammals, using data from the IUCN Red List.
"Our results show that alien species are the second most common threat associated with species that have gone completely extinct from these groups since 1500AD," says study leader Professor Tim Blackburn, Professor of Invasion Biology at UCL and Visiting Professorial Fellow at the University of Adelaide.
Alien species are just behind the most common threat averaged over all five groups ─ the most common being overexploitation of biological resources. They are, however, the most common threat associated with extinctions in each of three of the five groups analysed (amphibians, reptiles and mammals), and the most common threat when averaged over all the vertebrates (birds, amphibians, reptiles and mammals).
Across the globe, Australia has the highest rate of recent mammalian extinctions in the wild. Co-author Associate Professor Phill Cassey, Head of the University of Adelaide's Invasion Ecology Group in the Environment Institute, says human activities were clearly raising extinction rates and the introduction of alien species is one of the leading causes.
"This study clearly shows the consequences of human participation in indirect species extinction," Associate Professor Cassey says.
"Many of these introductions have come through the legacy of European colonisation and the associated acclimatisation of animals and plants, which have become pests and weeds. However, with increased globalisation we now have a new suite of biological invaders: zoonotic diseases which because of airborne travel can arrive in the country in less than a day; and a large illegal biological trade in wildlife. This latter group is probably the least known, and therefore of considerable concern.
"The problem is that once these introduced species become established, eradication can be incredibly difficult. That is why we need such stringent biosecurity and to remain vigilant."
In Australia, the "classic cases" of introduced mammalian species impacting biodiversity and causing extinctions are the generalist herbivores (rabbits, goats, pigs and camels) and the predators (feral cats and foxes).
"There have been a number of small to medium-sized Australian mammals now extinct because of these predators," he says.
The sources of invasive freshwater species in Europe's lakes and rivers
Journal information: Biology Letters
Provided by University of Adelaide
Citation: Alien plants and animals drive native species to extinction (2016, February 22) retrieved 23 January 2020 from https://phys.org/news/2016-02-alien-animals-native-species-extinction.html
Addressing feral cats' diet may help protect native species
Big-brained mammals more likely to go extinct, study says
Australia aims to end extinction of native wildlife by 2020
Feral cats behind extinction of unique Aussie mammals: study
Delayed legacy of invasive species
Carcasses important for plants and insects in the Oostvaardersplassen Nature Reserve
The color of your clothing can impact wildlife
Caterpillar loss in tropical forest linked to extreme rain, temperature events
Plants absorb lead from perovskite solar cells more than expected
Mayfly populations falling fast in North America
Insecticides becoming more toxic to honey bees


text:
João Pizarro Gabizo (Rio de Janeiro,  – Rio de Janeiro, ) foi um médico brasileiro.

Foi eleito membro honorário da Academia Nacional de Medicina em 3 de novembro de 1903.

Patronos da Academia Nacional de Medicina
Naturais da cidade do Rio de Janeiro


text:
Exclusive: CRYPTEX Premier Cover Of SAVATAGE Classic "Gutter Ballet"
August 16, 2017, 4 years ago
news heavy metal cryptek savatage
There are songs that last for and influence whole generations. And there are bands that do not only cover them but rather find an outstanding way to make them their own – so that an interpretation like this sometimes becomes so much more than just a cover version.
And there are really impressive examples of this – like the one Cryptex gave with an epic version of Savatage's "Gutter Ballet" at this year's 70000 Tons Of Metal Cruise, where they amazed several metalheads (and themselves) with how much this song seemed to be made for the band around singer Simon Moskon. Cryptex thereby inspire with a progressive passion that to date seemed to be a unique feature of Savatage.
But this must not remain an exclusive experience for selected sailors. And so the band has now recorded a live session video of their version of this masterpiece just before the start of their autumn tour. BraveWords is premiering this first result of the three-part Rain Shelter Sessions:
For the band's Anthems of Glory Tour 2017, fans can not only expect an especially designed light show but also (and for the first time after the release of "Madeleine Effect") brand new song material from the progressive rockers.


Given the intense focus on Encryption and Privacy in the recent months, it is a great time for us to better understand the largest encrypted network and the currency used in that environment.
Matt Devost, an international security expert specializing in cybersecurity, counterterrorism, critical infrastructure protection, intelligence, and risk management will lead the discussion. Thank you Bob Gourley for the introduction to Matt!
Matt is currently the President & CEO of FusionX, LLC, a global cybersecurity, technology, and risk management solutions company. He helps a global clientele identify and manage dynamic cyberthreats in complex operational environments.
Matt holds an appointment as a special government advisor to counsel the U.S. Department of Defense leadership on a variety of security issues. He is also on the Black Hat advisory board, helping to shape the agenda for a series of world-class information security conferences. Additionally, Matt serves as a Senior Advisor to CrucialPoint, has been an Adjunct Professor at Georgetown University since 2002 teaching the flagship graduate course entitled "Information Warfare and Security", and is a Founding Director of the Cyberconflict Studies Association.


Our Hats Off to Carol Martin…But, Carol, Please Keep Yours On!
"I have worn a lot of hats for Camp Joy – a lot of enjoyable hats! It all started when I was a young attorney and my law firm put out a communication asking for an interested candidate to serve on Camp Joy's Board. I had gone to summer camps, loved the outdoors and am very pro-environment so it seemed like a good fit." Thus, Carol Martin donned her first Joy hat.
When Carol held her Board seat, one of the Board's endeavors she recalled was the first ropes course being built and the birth of the Venture Out! Leadership Program. Board goals included a capital campaign for building Venture Out facilities and repairing youth cabins. There was also a strong focus on the school Outdoor Education Program emphasizing nature and the environment. "An important aim of the program was to help students understand their prejudices, by allowing them to interact with students from different schools/backgrounds (social, economic, and racial) in a natural setting. The idea was to get students, who were not ordinarily around each other, to interact, learn from each other and realize they had things in common," Carol reflected.
Carol has never taken off the Supporter Hat, and today it remains squarely planted atop her blonde hair. "I was lucky to find Joy! It's a wonderful organization!" And Carol Martin, Camp Joy was lucky to find you! Thank you for your time, your love and your invaluable thirty-three years of service. Please keep on wearing those hats…who knows what the next one might be? Our hats are off to you, indeed!
« Despite Our Differences, We Were All The Same.


text:
We provide many services to Harvard's community members and guests. For international visitors from academic institutions or governments, and for colleagues at Harvard who wish to host internationals, the Marshal's Office can schedule substantive meetings and private tours. The delegate program coordinates Harvard representation for events at academic institutions in the U.S. and abroad. And the gift program offers assistance with gifts for official business.
Harvard University, the oldest institution of higher education in the United States, is an open campus that welcomes thousands of visitors from around the world every year. The Office of the University Marshal in particular hosts international individuals and delegations seeking substantive dialogue with members of the Harvard community on shared areas of interest. These individuals include, but are not limited to, government officials, university leaders, and professionals in various fields participating in fellowships or special programs sponsored by official entities such as local...
Read more about International Visitors Program
The President receives many invitations to attend inaugurations and special ceremonies at institutions of higher education around the globe.
When he is unable to attend, we work to identify a suitable substitute. Often, faculty who have a meaningful affiliation with the inviting institution, or a local alumnus/a, are asked to represent Harvard.
Delegates deliver congratulatory greetings on behalf of the University and participate in various activities, including a traditional academic procession. Since those institutions participating in the academic...
Read more about Delegates
***IMPORTANT UPDATE: Due to the Coronavirus (COVID-19), beginning on March 13, 2020, the staff of the University Marshal's Office will be working remotely until further notice. Gifts will not be available for purchase from our inventory during this time. We apologize for the inconvenience. We may still be able to help members of the Harvard community to place orders directly with our vendors, including customized...
Read more about Buy a Gift


text:
Police release sketch of suspect in Upstate loan company robbery
Carla Field
Digital Managing Editor
Spartanburg Police
Robbery suspect
SOURCE: Spartanburg Police
Spartanburg police have released a sketch of man they say robbed a personal loan company Tuesday.Employees of Financial Trust Inc. on John B. White Sr. Boulevard in Spartanburg said a man came into the company at about 3:50 p.m., forced his way behind the counter, confronted the manager and demanded money. The employees said the man was armed with a black revolver. The manager put cash into a light red book bag the man was carrying. The man fled on foot toward W.O. Ezell Boulevard. Officers who responded to the robbery set up a perimeter and searched the area with a K-9, but were unable to find the man.Employees described the man as about 50 years old, about 6 feet tall and weighing about 240 pounds. He was wearing a burgundy and gold Washington Redskins toboggan hat, a black shirt and blue pants.Police are asking that anyone who recognizes the man in the sketch or who has information to call Crime Stoppers at 1-888-CRIMESC, or Spartanburg police at 864-809-0840.
SPARTANBURG, S.C. —
Spartanburg police have released a sketch of man they say robbed a personal loan company Tuesday.
Employees of Financial Trust Inc. on John B. White Sr. Boulevard in Spartanburg said a man came into the company at about 3:50 p.m., forced his way behind the counter, confronted the manager and demanded money. The employees said the man was armed with a black revolver.
The manager put cash into a light red book bag the man was carrying. The man fled on foot toward W.O. Ezell Boulevard.
Officers who responded to the robbery set up a perimeter and searched the area with a K-9, but were unable to find the man.
Employees described the man as about 50 years old, about 6 feet tall and weighing about 240 pounds. He was wearing a burgundy and gold Washington Redskins toboggan hat, a black shirt and blue pants.
Police are asking that anyone who recognizes the man in the sketch or who has information to call Crime Stoppers at 1-888-CRIMESC, or Spartanburg police at 864-809-0840.


text:
Трі́щини земно́ї кори́ - розриви у гірських породах; утворюються в результаті тектонічних рухів і під впливом процесів фізичного вивітрювання.

Див. також

 Тріщинуватість гірських порід

Література

 "Геологический словарь" в 2-х томах, М, 1978.

Геоморфологія
Орологія


text:
43 new ESP models
Jack White unplugs
Joyo unveils its own take on the EBow, the JGE-01 infinite sustainer
By Michael Astley-Brown published 30 August 19
$69 handheld unit boasts two modes
Over 40 years since its introduction, the EBow has remained relatively unopposed in the handheld infinite sustainer market - at least until TC Electronic's Aeon arrived last year, and now Joyo has released its own take, the JGE-01.
The pearl white polymide construction may not look quite as dashing as TC's effort, but the JGE-01 does offer the advantage of two sustainer effects for electric guitar: Normal and Overtone.
(Image credit: Joyo Audio)
While the difference between the two settings is subtle, you've gotta love an extra switch, and the whole lot is powered by a single 9V battery.
The JGE-01 is available now for $69.99 - see Joyo Audio for more.
Michael Astley-Brown
Editor-in-Chief, GuitarWorld.com
Mike is Editor-in-Chief of GuitarWorld.com, in addition to being an offset fiend and recovering pedal addict. He has a master's degree in journalism, and has spent the past decade writing and editing for guitar publications including MusicRadar, Total Guitar and Guitarist, as well as a decade-and-a-half performing in bands of variable genre (and quality). In his free time, you'll find him making progressive instrumental rock under the nom de plume Maebe.
Frank Zappa and The Mothers' legendary 1971 Fillmore East shows to be released in their entirety in mammoth new eight-disc box set
Keb' Mo' previews his upcoming album with breezy new single, Good To Be (Home Again)
ESP unveils 43 new LTD and LTD Deluxe models in mammoth drop
Eddie Van Halen's former guitar tech Tom Weber recalls his insane "trial-by-fire" job interview
Jack White shares soothing, stripped-back acoustic ballad, Love Is Selfish


Now each day your amounts of solicitors is boosting quickly as part of United States Of America. Based on statistic there are more versus 700000 solicitors as part of United States Of America. There was an excellent rival anywhere between solicitors for customers. Clients suffering from Homes or even insurance situation is commonly desired simply by your solicitors as they can secure billion dollars in only 1 situation.Looking to legal counsel are a significant task for you really to achieve your objective. Because of the fact your life of numerous solicitors, lawyers and/or lawyer are quiet evident, acquiring any is not that stressful. But then, you need to devote your brain your being choosy can be a bonus. Of course, you wish to need legal counsel that is not merely built with expertise and/or expertise and alongside close reputation and/or ideal character.Below are suggestions to consider prior to using legal counsel.
Other more future matters have always been related to accident, such as for example road mishaps. The newest statistic implies that the amount of mishaps at USA presents enhanced seventy five as compared to endure 5 years. Ones charges at drunken driving matters tend to be more complicated. It is possible to drop their driving licence and in extreme situations could face prison days as well as jail. Such situation you'll need the experienced legal representative to undertake their case then safeguard a person. Your prices for hiring all certified layers can move up towards 10000 or higher.These will be the significant ways in which the best domestic physical violence attorney will help his/her customer and in particular matters the youngsters associated with family members also. Your attorney are involved in various areas and in completely different circumstances family members life, company legislation, work legislation ... He can exclusively advise you and take legit action. Here's how to pick it to be seriously defended.
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A surviving spouse was eligible for accept a house as assets after will loss of will mate. These types of liberties need to be transferred to the youngsters off prior marriages. Ones ownership liberties out of retirement, IRA, furthermore your retirement methods should be settled.The custody regarding the son or daughter has to become determined in the event of your divorce. This is based on the very best attention regarding the son or daughter. The conventional concerning residing is thought about. The age, assets, financial resources then health regarding the events are considered aswell. Resources of earning come with commissions, inheritances, gift suggestions wages, Banja Luka income, then opportunities.It can be very hard to find a reliable furthermore trustworthy criminal activity lawyer. There are a few golden you need to adhere if you want to find the correct criminal activity attorneys. They're most special guidelines that you must always consider and not overlook. Choosing the best attorney is authentic frustration. Regarding unlawful solicitors it could be life changing. In this article My Goal Is To reveal a couple of of good use guideposts which will surely help you retain concentrated furthermore planning the proper way.


text:
Forsteo 20 micrograms/80 microlitres solution for injection in pre-filled pen
Eli Lilly and Company Limited contact details
teriparatide
Last updated on emc: 15 Dec 2017
FORSTEO 20 micrograms/80 microlitres solution for injection in pre-filled pen.
Each dose of 80 microlitres contains 20 micrograms of teriparatide*.
One pre-filled pen of 2.4 mL contains 600 micrograms of teriparatide (corresponding to 250 micrograms per mL).
*Teriparatide, rhPTH(1-34), produced in E. coli, using recombinant DNA technology, is identical to the 34 N-terminal amino acid sequence of endogenous human parathyroid hormone.
Solution for injection.
Colourless, clear solution.
Forsteo is indicated in adults.
Treatment of osteoporosis in postmenopausal women and in men at increased risk of fracture (see section 5.1). In postmenopausal women, a significant reduction in the incidence of vertebral and non-vertebral fractures but not hip fractures has been demonstrated.
Treatment of osteoporosis associated with sustained systemic glucocorticoid therapy in women and men at increased risk for fracture (see section 5.1).
The recommended dose of Forsteo is 20 micrograms administered once daily.
The maximum total duration of treatment with Forsteo should be 24 months (see section 4.4). The 24-month course of Forsteo should not be repeated over a patient's lifetime.
Patients should receive supplemental calcium and vitamin D supplements if dietary intake is inadequate.
Following cessation of Forsteo therapy, patients may be continued on other osteoporosis therapies.
Patients with renal impairment
Forsteo must not be used in patients with severe renal impairment (see section 4.3). In patients with moderate renal impairment, Forsteo should be used with caution. No special caution is required for patients with mild renal impairment.
Patients with hepatic impairment
No data are available in patients with impaired hepatic function (see section 5.3). Therefore, Forsteo should be used with caution.
Paediatric population and young adults with open epiphyses
The safety and efficacy of Forsteo in children and adolescents less than 18 years has not been established. Forsteo should not be used in paediatric patients (less than 18 years), or young adults with open epiphyses.
Elderly patients
Dosage adjustment based on age is not required (see section 5.2).
Forsteo should be administered once daily by subcutaneous injection in the thigh or abdomen.
Patients must be trained to use the proper injection techniques (see section 6.6). A user manual is also available to instruct patients on the correct use of the pen.
• Pregnancy and breast-feeding (see sections 4.4 and 4.6)
• Pre-existing hypercalcaemia
• Severe renal impairment
• Metabolic bone diseases (including hyperparathyroidism and Paget's disease of the bone) other than primary osteoporosis or glucocorticoid-induced osteoporosis
• Unexplained elevations of alkaline phosphatase
• Prior external beam or implant radiation therapy to the skeleton
• Patients with skeletal malignancies or bone metastases should be excluded from treatment with teriparatide
Serum and urine calcium
In normocalcaemic patients, slight and transient elevations of serum calcium concentrations have been observed following teriparatide injection. Serum calcium concentrations reach a maximum between 4 and 6 hours and return to baseline by 16 to 24 hours after each dose of teriparatide. Therefore, if blood samples for serum calcium measurements are taken, this should be done at least 16 hours after the most recent Forsteo injection. Routine calcium monitoring during therapy is not required.
Forsteo may cause small increases in urinary calcium excretion, but the incidence of hypercalciuria did not differ from that in the placebo-treated patients in clinical trials.
Forsteo has not been studied in patients with active urolithiasis. Forsteo should be used with caution in patients with active or recent urolithiasis because of the potential to exacerbate this condition.
Orthostatic hypotension
In short-term clinical studies with Forsteo, isolated episodes of transient orthostatic hypotension were observed. Typically, an event began within 4 hours of dosing and spontaneously resolved within a few minutes to a few hours. When transient orthostatic hypotension occurred, it happened within the first several doses, was relieved by placing subjects in a reclining position, and did not preclude continued treatment.
Caution should be exercised in patients with moderate renal impairment.
Younger adult population
Experience in the younger adult population, including premenopausal women, is limited (see section 5.1). Treatment should only be initiated if the benefit clearly outweighs risks in this population.
Women of childbearing potential should use effective methods of contraception during use of Forsteo. If pregnancy occurs, Forsteo should be discontinued.
Duration of treatment
Studies in rats indicate an increased incidence of osteosarcoma with long-term administration of teriparatide (see section 5.3). Until further clinical data become available, the recommended treatment time of 24 months should not be exceeded.
In a study of 15 healthy subjects administered digoxin daily to steady state, a single Forsteo dose did not alter the cardiac effect of digoxin. However, sporadic case reports have suggested that hypercalcaemia may predispose patients to digitalis toxicity. Because Forsteo transiently increases serum calcium, Forsteo should be used with caution in patients taking digitalis.
Forsteo has been evaluated in pharmacodynamic interaction studies with hydrochlorothiazide. No clinically significant interactions were noted.
Co-administration of raloxifene or hormone replacement therapy with Forsteo did not alter the effects of Forsteo on serum or urine calcium or on clinical adverse events.
Women of childbearing potential / Contraception in females
Forsteo is contraindicated for use during pregnancy (see section 4.3).
Forsteo is contraindicated for use during breast-feeding. It is not known whether teriparatide is excreted in human milk.
Studies in rabbits have shown reproductive toxicity (see section 5.3). The effect of teriparatide on human foetal development has not been studied. The potential risk for humans is unknown.
Forsteo has no or negligible influence on the ability to drive and use machines. Transient, orthostatic hypotension or dizziness was observed in some patients. These patients should refrain from driving or the use of machines until symptoms have subsided.
Summary of the safety profile
The most commonly reported adverse reactions in patients treated with Forsteo are nausea, pain in limb, headache and dizziness.
Tabulated list of adverse reactions
Of patients in the teriparatide trials, 82.8 % of the Forsteo patients and 84.5 % of the placebo patients reported at least 1 adverse event.
The adverse reactions associated with the use of teriparatide in osteoporosis clinical trials and post-marketing exposure are summarised in the table below. The following convention has been used for the classification of the adverse reactions: very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000), very rare (< 1/10,000).
Blood and lymphatic system disorders
Common: Anaemia
Immune System Disorder
Rare: Anaphylaxis
Common: Hypercholesterolaemia
Uncommon: Hypercalcaemia greater than 2.76 mmol/L, hyperuricaemia
Rare: Hypercalcaemia greater than 3.25 mmol/L
Common: Depression
Common: Dizziness, headache, sciatica, syncope
Common: Vertigo
Common: Palpitations
Uncommon: Tachycardia
Common: Hypotension
Common: Dyspnoea
Uncommon: Emphysema
Common: Nausea, vomiting, hiatus hernia, gastro-oesophageal reflux disease
Uncommon: Haemorrhoids
Common: Sweating increased
Very common: Pain in limb
Common: Muscle cramps
Uncommon: Myalgia, arthralgia, back cramp/pain*
Uncommon: Urinary incontinence, polyuria, micturition urgency, nephrolithiasis
Rare: Renal failure/impairment
Common: Fatigue, chest pain, asthenia, mild and transient injection site events, including pain, swelling, erythema, localised bruising, pruritus and minor bleeding at injection site
Uncommon: Injection site erythema, injection site reaction
Rare: Possible allergic events soon after injection: acute dyspnoea, oro/facial oedema, generalised urticaria, chest pain, oedema (mainly peripheral)
Uncommon: Weight increased, cardiac murmur, alkaline phosphatase increase
* Serious cases of back cramp or pain have been reported within minutes of the injection.
Description of selected adverse reactions
In clinical trials the following reactions were reported at a ≥ 1 % difference in frequency from placebo: vertigo, nausea, pain in limb, dizziness, depression, dyspnoea.
Forsteo increases serum uric acid concentrations. In clinical trials, 2.8 % of Forsteo patients had serum uric acid concentrations above the upper limit of normal compared with 0.7 % of placebo patients. However, the hyperuricaemia did not result in an increase in gout, arthralgia, or urolithiasis.
In a large clinical trial, antibodies that cross-reacted with teriparatide were detected in 2.8 % of women receiving Forsteo. Generally, antibodies were first detected following 12 months of treatment and diminished after withdrawal of therapy. There was no evidence of hypersensitivity reactions, allergic reactions, effects on serum calcium, or effects on Bone Mineral Density (BMD) response.
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via Ireland: HPRA Pharmacovigilance, Earlsfort Terrace, IRL - Dublin 2, Tel: +353 1 6764971, Fax: +353 1 6762517; website: www.hpra.ie; e-mail: [email protected], or United Kingdom: Yellow Card Scheme; website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.
Forsteo has been administered in single doses of up to 100 micrograms and in repeated doses of up to 60 micrograms/day for 6 weeks.
The effects of overdose that might be expected include delayed hypercalcaemia and risk of orthostatic hypotension. Nausea, vomiting, dizziness, and headache can also occur.
Overdose experience based on post-marketing spontaneous reports
In post-marketing spontaneous reports, there have been cases of medication error where the entire contents (up to 800 mcg) of the teriparatide pen have been administered as a single dose. Transient events reported have included nausea, weakness/lethargy and hypotension. In some cases, no adverse events occurred as a result of the overdose. No fatalities associated with overdose have been reported.
Overdose management
There is no specific antidote for Forsteo. Treatment of suspected overdose should include transitory discontinuation of Forsteo, monitoring of serum calcium, and implementation of appropriate supportive measures, such as hydration.
Pharmaco-therapeutic group: Calcium homeostasis, parathyroid hormones and analogues, ATC code: H05 AA02.
Endogenous 84-amino-acid parathyroid hormone (PTH) is the primary regulator of calcium and phosphate metabolism in bone and kidney. Forsteo (rhPTH[1-34]) is the active fragment (1-34) of endogenous human parathyroid hormone. Physiological actions of PTH include stimulation of bone formation by direct effects on bone-forming cells (osteoblasts) indirectly increasing the intestinal absorption of calcium and increasing the tubular re-absorption of calcium and excretion of phosphate by the kidney.
Pharmacodynamic effects
Forsteo is a bone formation agent to treat osteoporosis. The skeletal effects of Forsteo depend upon the pattern of systemic exposure. Once-daily administration of Forsteo increases apposition of new bone on trabecular and cortical bone surfaces by preferential stimulation of osteoblastic activity over osteoclastic activity.
Independent risk factors, for example, low BMD, age, the existence of previous fracture, family history of hip fractures, high bone turnover and low body mass index should be considered in order to identify women and men at increased risk of osteoporotic fractures who could benefit from treatment.
Premenopausal women with glucocorticoid-induced osteoporosis should be considered at high risk for fracture if they have a prevalent fracture or a combination of risk factors that place them at high risk for fracture (e.g., low bone density [e.g., T-score ≤−2], sustained high dose glucocorticoid therapy [e.g., ≥7.5 mg/day for at least 6 months], high underlying disease activity, low sex steroid levels).
Postmenopausal osteoporosis
The pivotal study included 1,637 postmenopausal women (mean age 69.5 years). At baseline, ninety percent of the patients had one or more vertebral fractures and on average, vertebral BMD was 0.82 g/cm2 (equivalent to a T-score = -2.6). All patients were offered 1,000 mg calcium per day and at least 400 IU vitamin D per day. Results from up to 24 months (median: 19 months) treatment with Forsteo demonstrate statistically significant fracture reduction (Table 1). To prevent one or more new vertebral fractures, 11 women had to be treated for a median of 19 months.
Fracture Incidence in Postmenopausal Women
Forsteo
(95% CI)
vs placebo
New vertebral fracture (≥1)a
(0.22, 0.55)
Multiple vertebral fractures (≥2)a
Non-vertebral fragility fractures c
Major non-vertebral fragility fracturesc (hip, radius, humerus, ribs and pelvis)
Abbreviations: N = number of patients randomly assigned to each treatment group; CI = Confidence Interval.
a The incidence of vertebral fractures was assessed in 448 placebo and 444 Forsteo patients who had baseline and follow-up spine radiographs
b p≤0.001 compared with placebo
c A significant reduction in the incidence of hip fractures has not been demonstrated
d p≤0.025 compared with placebo
After 19 months (median) treatment, bone mineral density (BMD) had increased in the lumbar spine and total hip, respectively, by 9 % and 4 % compared with placebo (p < 0.001).
Post-treatment management: Following treatment with Forsteo, 1,262 postmenopausal women from the pivotal trial enrolled in a post-treatment follow-up study. The primary objective of the study was to collect safety data of Forsteo. During this observational period, other osteoporosis treatments were allowed and additional assessment of vertebral fractures was performed.
During a median of 18 months following discontinuation of Forsteo, there was a 41 % reduction (p = 0.004) compared with placebo in the number of patients with a minimum of one new vertebral fracture.
In an open-label study, 503 postmenopausal women with severe osteoporosis and a fragility fracture within the previous 3 years (83 % had received previous osteoporosis therapy) were treated with Forsteo for up to 24 months. At 24 months, the mean increase from baseline in lumbar spine, total hip and femoral neck BMD was 10.5 %, 2.6 %, and 3.9 % respectively. The mean increase in BMD from 18 to 24 months was 1.4 %, 1.2 %, and 1.6 % at the lumbar spine, total hip and femoral neck, respectively.
A 24-month, randomized, double-blind, comparator-controlled Phase 4 study included 1,360 postmenopausal women with established osteoporosis. 680 subjects were randomised to Forsteo and 680 subjects were randomised to oral risedronate 35 mg/week. At baseline, the women had a mean age of 72.1 years and a median of 2 prevalent vertebral fractures; 57.9 % of patients had received previous bisphosphonate therapy and 18.8 % took concomitant glucocorticoids during the study. 1,013 (74.5 %) patients completed the 24-month follow-up. The mean (median) cumulative dose of glucocorticoid was 474.3 (66.2) mg in the teriparatide arm and 898.0 (100.0) mg in the risedronate arm. The mean (median) vitamin D intake for the teriparatide arm was 1433 IU/day (1400 IU/day) and for the risedronate arm was 1191 IU/day (900 IU/day). For those subjects who had baseline and follow-up spine radiographs, the incidence of new vertebral fractures was 28/516 (5.4 %) in Forsteo- and 64/533 (12.0 %) in risedronate-treated patients, relative risk (95 % CI) = 0.44 (0.29-0.68), P < 0.0001. The cumulative incidence of pooled clinical fractures (clinical vertebral and non vertebral fractures) was 4.8 % in Forsteo and 9.8 % in risedronate-treated patients, hazard ratio (95 % CI) = 0.48 (0.32-0.74), P=0.0009.
Male osteoporosis
437 patients (mean age 58.7 years) were enrolled in a clinical trial for men with hypogonadal (defined as low-morning free testosterone or an elevated FSH or LH) or idiopathic osteoporosis. Baseline spinal and femoral neck bone mineral density mean T-scores were -2.2 and -2.1, respectively. At baseline, 35 % of patients had a vertebral fracture and 59 % had a non-vertebral fracture.
All patients were offered 1,000 mg calcium per day and at least 400 IU vitamin D per day. Lumbar spine BMD significantly increased by 3 months. After 12 months, BMD had increased in the lumbar spine and total hip by 5 % and 1 %, respectively, compared with placebo. However, no significant effect on fracture rates was demonstrated.
Glucocorticoid-induced osteoporosis
The efficacy of Forsteo in men and women (N =428) receiving sustained systemic glucocorticoid therapy (equivalent to 5 mg or greater of prednisone for at least 3 months) was demonstrated in the 18-month primary phase of a 36-month, randomised, double-blind, comparator-controlled study (alendronate 10 mg/day). Twenty-eight percent of patients had one or more radiographic vertebral fractures at baseline. All patients were offered 1,000 mg calcium per day and 800 IU vitamin D per day.
This study included postmenopausal women (N =277), premenopausal women (N =67), and men (N =83). At baseline, the postmenopausal women had a mean age of 61 years, mean lumbar spine BMD T-score of −2.7, median prednisone equivalent dose of 7.5 mg/day, and 34 % had one or more radiographic vertebral fractures; premenopausal women had a mean age of 37 years, mean lumbar spine BMD T-score of −2.5, median prednisone equivalent dose of 10 mg/day, and 9 % had one or more radiographic vertebral fractures; and men had a mean age of 57 years, mean lumbar spine BMD T-score of −2.2, median prednisone equivalent dose of 10 mg/day, and 24 % had one or more radiographic vertebral fractures.
Sixty-nine percent of patients completed the 18-month primary phase. At the 18-month endpoint, Forsteo significantly increased lumbar spine BMD (7.2 %) compared with alendronate (3.4 %) (p<0.001). Forsteo increased BMD at the total hip (3.6 %) compared with alendronate (2.2 %) (p<0.01), as well as at the femoral neck (3.7 %) compared with alendronate (2.1 %) (p<0.05). In patients treated with teriparatide, lumbar spine, total hip and femoral neck BMD increased between 18 and 24 months by an additional 1.7 %, 0.9 %, and 0.4 %, respectively.
At 36 months, analysis of spinal X-rays from 169 alendronate patients and 173 Forsteo patients showed that 13 patients in the alendronate group (7.7 %) had experienced a new vertebral fracture compared with 3 patients in the Forsteo group (1.7 %) (p=0.01). In addition, 15 of 214 patients in the alendronate group (7.0 %) had experienced a non-vertebral fracture compared with 16 of 214 patients in the Forsteo group (7.5 %) (p=0.84).
In premenopausal women, the increase in BMD from baseline to 18-month endpoint was significantly greater in the Forsteo group compared with the alendronate group at the lumbar spine (4.2 % versus −1.9 %; p<0.001) and total hip (3.8 % versus 0.9 %; p =0.005). However, no significant effect on fracture rates was demonstrated.
The volume of distribution is approximately 1.7 L/kg. The half-life of Forsteo is approximately 1 hour when administered subcutaneously, which reflects the time required for absorption from the injection site.
No metabolism or excretion studies have been performed with Forsteo, but the peripheral metabolism of parathyroid hormone is believed to occur predominantly in liver and kidney.
Forsteo is eliminated through hepatic and extra-hepatic clearance (approximately 62 L/hr in women and 94 L/hr in men).
No differences in Forsteo pharmacokinetics were detected with regard to age (range 31 to 85 years). Dosage adjustment based on age is not required.
Teriparatide was not genotoxic in a standard battery of tests. It produced no teratogenic effects in rats, mice or rabbits. There were no important effects observed in pregnant rats or mice administered teriparatide at daily doses of 30 to 1,000 µg/kg. However, foetal resorption and reduced litter size occurred in pregnant rabbits administered daily doses of 3 to 100 µg/kg. The embryotoxicity observed in rabbits may be related to their much greater sensitivity to the effects of PTH on blood-ionised calcium compared with rodents.
Rats treated with near-lifetime daily injections had dose-dependent exaggerated bone formation and increased incidence of osteosarcoma most probably due to an epigenetic mechanism. Teriparatide did not increase the incidence of any other type of neoplasia in rats. Due to the differences in bone physiology in rats and humans, the clinical relevance of these findings is probably minor. No bone tumours were observed in ovariectomised monkeys treated for 18 months or during a 3-year follow-up period after treatment cessation. In addition, no osteosarcomas have been observed in clinical trials or during the post-treatment follow-up study.
Animal studies have shown that severely reduced hepatic blood flow decreases exposure of PTH to the principal cleavage system (Kupffer cells) and consequently clearance of PTH(1-84).
Sodium acetate (anhydrous)
Metacresol
Hydrochloric acid (for pH adjustment)
Sodium hydroxide (for pH adjustment)
Water for injections
In the absence of compatibility studies, this medicinal product must not be mixed with other medicinal products.
Chemical, physical and microbiological in-use stability has been demonstrated for 28 days at 2°C-8°C. Once opened, the product may be stored for a maximum of 28 days at 2°C to 8°C. Other in-use storage times and conditions are the responsibility of the user.
Store in a refrigerator (2°C-8°C) at all times. The pen should be returned to the refrigerator immediately after use. Do not freeze.
Do not store the injection device with the needle attached.
2.4 mL solution in cartridge (siliconised Type I glass) with a plunger (halobutyl rubber), disc seal (polyisoprene/bromobutyl rubber laminate)/aluminium assembled into a disposable pen.
Forsteo is available in pack sizes of 1 or 3 pens. Each pen contains 28 doses of 20 micrograms (per 80 microlitres).
Not all pack sizes may be marketed.
Forsteo is supplied in a pre-filled pen. Each pen should be used by only one patient. A new, sterile needle must be used for every injection. Each Forsteo pack is provided with a User Manual that fully describes the use of the pen. No needles are supplied with the product. The device can be used with insulin pen injection needles. After each injection, the Forsteo pen should be returned to the refrigerator.
Forsteo should not be used if the solution is cloudy, coloured or contains particles.
Please also refer to the user manual for instructions on how to use the pen.
Any unused product or waste material should be disposed of in accordance with local requirements.
Eli Lilly Nederland B.V., Papendorpseweg 83, 3528 BJ Utrecht, The Netherlands
EU/1/03/247/001: 1 pre-filled pen
EU/1/03/247/002: 3 pre-filled pens
Date of first authorisation: 10 June 2003
Date of the last renewal: 13 February 2013
Detailed information on this medicinal product is available on the website of the European Medicines Agency http://www.ema.europa.eu.
FS18M
Lilly House, Priestley Road, Basingstoke, Hampshire, RG24 9NL
http://www.lilly.co.uk


text:
Jewish World Review Feb. 16, 2011 / 12 Adar I, 5771
And now for the important news ....
http://www.JewishWorldReview.com | Southern California basked in record heat last weekend while the rest of America recovered from the cold. It's an old Spanish legend that the hot desert breeze makes Californians crazy. It was so hot in Los Angeles Friday that Lindsay Lohan was sticking to her story.
Lady Gaga stole the show at the Grammy Awards Sunday at the Staples Center. The heavy favorites didn't win. In the evening's biggest upset surprise, the Grammy for Best Background Music went to Amy Winehouse's ambulance over Charlie Sheen's ambulance.
Donald Trump told a conservative meeting Friday he may run for president. He's certainly a man of his times. Of all the seventy million Baby Boomers, Donald Trump is the only one who's still wearing his Davy Crockett coonskin cap everywhere he goes.
The Conservative Political Action Conference heard speeches from GOP candidates Friday as the Mideast roiled. The news outside confused the conservatives at first. When they heard a Muslim president was stepping down, the speakers said nice things about Obama out of chivalry.
Egypt's new government began implementing democratic reforms Monday. The nation will be ruled by the secret police chief along with a council of army generals. Nothing says reform like adopting Germany's old law of succession should Hitler die in office.
Walmart said Monday it will try not to raise clothing prices, as commodity prices soared. Cotton futures prices are the highest since the War Between the States. The South never dreamed that fried food could double cotton prices by tripling the size of T-shirts.
New York Mayor Mike Bloomberg caught holy hell Monday after he told a drunk Irish joke at an Irish-American heritage dinner. He's done everything he can to make it up to the Irish community. He even invited Mel Gibson to City Hall to tell jokes about the Jews.
The Transportation Department considered plans Monday to require that all new cars be equipped with black box data recorders. This could save the legal profession. The GPS tracking alone could provide enough evidence to triple the divorce rate in six months.
Arnold Schwarzenegger announced Friday he's resuming his show business career and told his agent he will start fielding offers again. He's shrewd. In politics a twenty percent rating is just terrible but in television it puts you right behind American Idol.