Due to the upcoming subzero weather, Goshen Health will close several non-essential offices on Wednesday, January 30 and Thursday, January 31, 2019. See below for the office list.
All essential functions at Goshen Hospital will continue to operate as expected. Scheduled surgeries at Goshen Hospital and Goshen Surgery Center will continue as planned. Goshen Physicians Urgent Care will be open with the adjusted hours of 9 a.m. to 5 p.m.
During this time, patients should contact their office directly to confirm office closings and reschedule appointments. Offices listed above are expected to reopen on Friday, February 1, 2019, for regular business hours.


He spent the 1980 season with the Rangers before returning to the Mets for the final five years of what was a 23 year MLB career. Staub retired following the 1985 season with a career slash line of.279/.362/.431, 292 home runs, 499 doubles and 1,466 RBIs. One of the best contact hitters of his time, Staub struck out just 888 times in 9,720 at bats and drew 1,255 walks..
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Welcome To Contractors State License Services Online Bookstore!
Our inventory reflects a variety of popular Trade books that can be used to supplement your license exam preparation or as a valuable reference tool in practicing your trade.
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DVDs and Trade CDRs are available in the areas of License Exam Preparation, Estimating, Home Inspection and Business Management.
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text:
Q: How can I add a base table to an existing entity creating TPH model using Entity Framework? I have an existing table in my database called CarDesign that has a one to one relationship with Project. I want to add a base table called Design to use in a TPH table. So then I can add discriminators for things like BoatDesign. The problem is entity framework wants to just drop the old table and make a new one. How can I keep my data and have a discriminator to represent the current records?
I'm using entity framework 5 with SQL. I am also going to update to entity framework 6 if that helps the issue. Project is asp.net MVC4 with c#
Mapping

public class CarDesignMap : EntityTypeConfiguration<CarDesign>
    {
        public CarDesignMap()
        {
            // Primary Key
            this.HasKey(t => t.Id);

            // Properties
            //this.Property(t => t.Name)
            //.IsRequired();

            this.Property(t => t.RowVersion)
                .IsRequired()
                .IsFixedLength()
                .HasMaxLength(8)
                .IsRowVersion();

            // Relationships
            this.HasMany(t => t.InputVoltages)
                .WithMany(t => t.CarDesign)
                .Map(m =>
                {
                    m.ToTable("InputVoltageCarDesign");
                    m.MapLeftKey("CarDesign_Id");
                    m.MapRightKey("InputVoltage_Id");
                });

            this.HasMany(t => t.LensColors)
                .WithMany(t => t.CarDesign)
                .Map(m =>
                {
                    m.ToTable("LensCarDesign");
                    m.MapLeftKey("CarDesign_Id");
                    m.MapRightKey("LensColor_Id");
                });

            this.HasMany(t => t.LightSourceColors)
                .WithMany(t => t.CarDesign)
                .Map(m =>
                {
                    m.ToTable("LightSourceColorCarDesign");
                    m.MapLeftKey("CarDesign_Id");
                    m.MapRightKey("LightSourceColor_Id");
                });

            this.HasMany(t => t.Standards)
                .WithMany(t => t.CarDesign)
                .Map(m =>
                {
                    m.ToTable("StandardCarDesign");
                    m.MapLeftKey("CarDesign_Id");
                    m.MapRightKey("Standard_Id");
                });

            this.HasOptional(t => t.LightSource)
                .WithMany(t => t.CarDesign)
                .HasForeignKey(d => d.LightSourceId);
        }
    }

model
public class CarDesign
{
    public CarDesign()
    {
        Approvals = new List<Approval>();
        Standards = new List<Standard>();
        Connectors = new List<Connector>();
        InputVoltages = new List<InputVoltage>();
        LensColors = new List<LensColor>();
        LightSourceColors = new List<LightSourceColor>();
    }

    [Required]
    [Display(Name = "Product Name")]
    public string Name { get; set; }

    public PdsStatus Status { get; set; }

    public Guid SubmittedById { get; set; }
    [Display(Name = "Submitted By")]
    public virtual User SubmittedBy { get; set; }

    public Guid? ApprovedById { get; set; }
    [Display(Name = "Approved By")]
    public virtual User ApprovedBy { get; set; }

    [Display(Name = "Approval Date")]
    [DataType(DataType.Date)]
    public DateTime? ApprovalDate { get; set; }

    [Display(Name = "Submit Date")]
    [DataType(DataType.Date)]
    public DateTime SubmittalDate { get; set; }
    public string SubmittalDateDisplay
    {
        get
        {
            return (SubmittalDate == null) ? "Not Set" : ((DateTime)SubmittalDate).ToString("MM/dd/yy");
        }
    }

    public string Description { get; set; }

    [Display(Name = "Market and Uses")]
    public string MarketAndUses{get;set;}

    [Display(Name = "Target M & L")]
    [DataType(DataType.Currency)]
    public double? TargetPrice { get; set; }

    [Display(Name = "Annual Qty")]
    public int? AnnualQuantities { get; set; }

    [Display(Name = "Current Draw")]
    public double? CurrentDraw { get; set; }

    [Display(Name = "Light Source")]
    public int? LightSourceId { get; set; }
    public virtual LightSource LightSource { get; set; }

    public LengthUnitOfMeasure LengthUnitOfMeasure { get; set; }
    public WeightUnitOfMeasure WeightUnitOfMeasure { get; set; }
    public PhotometricIntensityUnitOfMeasure LightIntensityUnitOfMeasure{ get; set; }

    public virtual ICollection<Approval> Approvals { get; set; }
    public virtual ICollection<Standard> Standards { get; set; }
    public virtual ICollection<Connector> Connectors { get; set; }
    public virtual ICollection<InputVoltage> InputVoltages { get; set; }
    public virtual ICollection<LensColor> LensColors { get; set; }
    public virtual ICollection<LightSourceColor> LightSourceColors { get; set; }
        }
    }

so I would desire to have
public class CarDesign : Design
{
}

A: Since you want to adopt TPH inheritance, EF will have to create a table for the base class Design, thus droping your old CarDesign table. You can try to use migrations to avoid losing data but I've never tried to implement TPH with existing data so I cannot garantee that migrations will work for it (I'm afraid it probably won't).
As for the discriminator, EF already handles this for you.
The classes would look like this:
public abstract class Design
{
    Public int Id { get; set; }
    ...
}

public class CarDesign : Design
{
    ...
}

public class BoatDesign : Design
{
    ...
}

And then, you can choose to create a single DbSet for Design or you can create one DbSet for each subtype. Your choice here:
public DbSet<Design> Designs { get; set; }

or:
public DbSet<CarDesign> CarDesigns { get; set; }
public DbSet<BoatDesign> BoatDesigns { get; set; }

Or you can have all three DbSets.
In case you want query Designs DbSet and have it return only CarDesigns, you can do it like this:
var finishedCarDesigns = context.Designs.OfType<CarDesign>().Where(cd => cd.Finished = true);

Also, you may find this link useful: http://weblogs.asp.net/manavi/archive/2010/12/24/inheritance-mapping-strategies-with-entity-framework-code-first-ctp5-part-1-table-per-hierarchy-tph.aspx

A: If you started with Foo:
public class Foo
{
    public int ID { get; set; }
    public string Name { get; set; }
    public int BarID { get; set; }
    public virtual Bar Bar { get; set; }
}

Then added a base class Baz
public class Foo : Baz
{
    public string Name { get; set; }
    public int BarID { get; set; }
    public virtual Bar Bar { get; set; }
}

public class Baz
{
    public int ID { get; set; }
    public int ApprovedBy { get; set;
}

You could add your sql to the migration like this:
public override void Up()
{
    DropForeignKey("dbo.Foos", "BarID", "dbo.Bars");
    DropIndex("dbo.Foos", new[] { "BarID" });
    CreateTable(
        "dbo.Bazs",
        c => new
            {
                ID = c.Int(nullable: false, identity: true),
                ApprovedBy = c.Int(nullable: false),
                Name = c.String(),
                BarID = c.Int(),
                Discriminator = c.String(nullable: false, maxLength: 128),
            })
        .PrimaryKey(t => t.ID)
        .ForeignKey("dbo.Bars", t => t.BarID)
        .Index(t => t.BarID);

    //Put your sql here to run before the table is dropped
    Sql(@"INSERT INTO dbo.Bazs (Name, BarID, Discriminator)
          SELECT Name, BarID, 'Foo' FROM dbo.Foos");

    DropTable("dbo.Foos");
}

The sql gets more complicated if you have foreign keys to fix up. The only other thing I can think of is to go in stages:

*

*Make BoatDesign inherit from CarDesign and Migrate (a discriminator column will be added to the existing table)

*Add a new class CarDesign2 that also inherits from CarDesign (no database change required)

*Move the properties applicable only to CarDesign into CarDesign2 (no database change required)

*Script a table name change in the database for CarDesigns to Designs (Sql Server will generate a script that will move the data as well as drop and re-create)

*In the code change CarDesign to Design and CarDesign2 to CarDesign

*Look at the migration created by step 5. If it is dropping and recreating the CarDesign table then replace it with the sql generated in step 4, If it isn't woo-hoo!

*Let us know how you get on

redpajama_set_name: RedPajamaStackExchange


text:
import React from 'react';
import ReactDOM from 'react-dom';
import {withDefaultNowContext} from '../testing/NowContainer';
import {SOMERVILLE} from '../helpers/PerDistrict';
import PerDistrictContainer from '../components/PerDistrictContainer';
import fetchMock from 'fetch-mock/es5/client';
import SectionPage from './SectionPage';
import sectionJson from './sectionJson.fixture';

function testProps(props = {}) {
  const sectionId = sectionJson.section.id;
  return {
    sectionId,
    ...props
  };
}

function testRender(props = {}, context = {}) {
  const districtKey = context.districtKey || SOMERVILLE;
  const el = document.createElement('div');
  ReactDOM.render(withDefaultNowContext(
    <PerDistrictContainer districtKey={districtKey}>
      <SectionPage {...props} />
    </PerDistrictContainer>
  ), el);
  return {el};
}

beforeEach(() => {
  const sectionId = sectionJson.section.id;

  fetchMock.restore();
  fetchMock.get(`/api/sections/${sectionId}/section_json`, sectionJson);
});

it('renders without crashing', () => {
  const props = testProps();
  testRender(props);
});

it('renders everything after fetch', done => {
  const props = testProps();
  const {el} = testRender(props);

  setTimeout(() => {
    expect($(el).text()).toContain('ART MAJOR FOUNDATIONS (ART-302A)');
    expect($(el).text()).toContain('Room 201');
    expect($(el).text()).toContain('Schedule 2(M,R)');
    expect($(el).text()).toContain('Term FY');
    expect($(el).text()).toContain('Somerville High');
    expect($(el).find('.FlexibleRoster tbody > tr').length).toEqual(sectionJson.students.length);
    expect($(el).find('.FlexibleRoster tbody > tr').length).toEqual(9);
    done();
  }, 0);
});

redpajama_set_name: RedPajamaGithub


A quick glance at the King's College London's annual air quality map shows that on virtually every major road in London the levels of air quality are in the red danger zone. Switching from cars, buses and taxis to cycling is an obvious part of the solution, along with an extended Ultra Low Emission Zone (ULEZ), but cyclists, drivers and pedestrians need to know how to minimise the impact to themselves and to others.
Andrea Lee, healthy air campaigner at ClientEarth (a group of activist lawyers committed to a healthy planet) looks at the wider impacts of air pollution and Tom Bogdanowicz looks specifically at the impacts on cyclists and how to mitigate them.
Just how bad is the air that we breathe?
Depending on where you live and work, how or when you travel, and your general health, your impression of the air quality that you breathe will vary - from not even giving it a second thought to being unable to leave your house on some days.
Some of us will have been lulled into a false sense of security as our towns and cities are no longer shrouded in the thick black smogs which could reduce visibility to just a few metres, leaving an acrid taste in the back of your throat. This had serious consequences with thousands of deaths alone in the weeks following the Great Smog of 1952.
Public outrage, fuelled by newspapers and a vocal medical community, and successful lobbying by backbench MPs, led to the adoption of the Clean Air Act 1956. This ground-breaking legislation tackled the main source of pollution, coal from domestic heating. Eventually it led to the closing of factories and power stations in urban areas.
Sixty years on we face a much different challenge. Now the main sources of air pollution are emissions from motor vehicles, and in particular diesel vehicles, that produce very different pollutants to the smoke churned out by burning coal.
In the UK there are 40,000 estimated early deaths - almost 10,000 in London alone - caused by an invisible but toxic cocktail of pollutants. This includes particulate matter, which is less than a third of the width of a human hair (also referred to as PM10 and PM2.5 based on the diameter measured in microns), and nitrogen dioxide gas.
The impacts that air pollution has on people with respiratory problems are not surprising, though not many will appreciate that an asthma attack can lead to hospitalisation or worse. Even fewer people will realise that the main health impact is in fact through cardiovascular disease, triggering heart attacks, strokes and heart failure and reducing survival rates.
Air pollution is also known to cause lung and bladder cancer. It's linked to premature births and low birth weight. A study by King's College London and Queen Mary University has shown that long-term exposure to air pollution is stunting the lungs of children in London, something that will continue to affect them into their adult lives. There is also increasing evidence of links with diabetes, impaired cognitive functions and autism among other conditions and illnesses.
It's worrying, in the face of all of this, that legal limits of air pollution are being broken across the UK. In London, the Mayor identified 187 'Air Quality Focus Areas' - places where legal limits are broken, in some cases by up to three times. Oxford Street, Putney High Street and Brixton Road are now infamous air pollution hotspots, breaching limits for the whole of 2016 in just the first week of January.
These limits should have been met by 2010 but the government has admitted that much of the UK will not comply until 2020, and London not until 2025, 15 years after the deadline.
A generation of children will have grown up breathing dirty air that they should have been protected from.
There are serious questions about the ability of the government's new air quality plans to meet legal limits, even by 2025. That's why ClientEarth is pursuing its legal challenge against the government to force them to take action, and why more and more environment sectors are voicing their concerns.
The UK is not alone; few countries in Europe comply with legal limits. London has a monumental challenge to overcome. City comparisons are difficult but a study commissioned by the Mayor in 2014 ranked the capital 15th out of 36 selected world cities and 10th out of 18 European cities for air quality. That was below cities such as Berlin, Amsterdam, Paris and Budapest.
Reducing emissions from motor vehicles, diesel in particular, is crucial in wider transport network, construction and development, energy generation and use, industry and agriculture.
We need the Mayor and the UK government to back a range of ambitious and practical strategies to transform how and where people live, work and enjoy the city, in order to create a real clean air zone for a cleaner and healthier London.
People cycling and walking don't emit NO2, PM2.5 or PM10s but they aren't able to avoid breathing them. While all Londoners, can't avoid pollutants some face greater levels of pollution than others.
Dr James Woodcock and colleagues at Cambridge University looked at the risks and benefits of cycling to London hire bike users, including the impacts of pollution. They concluded that the benefits far outweighed the risks and pollution formed a very small part of the risk calculation.
Dr Audrey de Nazelle and her colleagues at Imperial College compared pollutants inhaled using different transport modes in Barcelona. They found that car users experienced higher concentrations compared to active commuters, but it evened out because of the greater ventilation rates of active travellers.
Other researchers have observed that journey time (often shorter by bike than by car in London) also affects exposure, as does 'distance from the tailpipe'. So riding in a wide cycle track separated from a busy road may reduce your pollutant intake compared to riding in the traffic stream. Using a side street will reduce it even further.
Dr Ben Barratt of King's College compared inhalation of black carbon by ambulance drivers, office workers, children and cycle couriers. The cycle couriers emerged with the second lowest intake and the ambulance drivers with the highest. Barratt suggests that the pollutants in an enclosed box (the ambulance) led to greater intake than that of couriers in the open air.
Of London road users, taxi drivers are perhaps the worst off, spending all day on busy roads inhaling some of the diesel fumes their own engines emit. It is not surprising that their union favours stronger legislation on air quality (black cabs will be switching to hybrid electric-petrol vehicles from 2018).
The academic literature consistently says the health benefits of cycling far outweigh the potential risks. So far there is little evidence that short-term exposure to pollutants has a marked impact on healthy individuals but there is no reason to inhale particles if you can avoid them.
The most obvious solution is to encourage others to cycle and minimise your own car use. If you can afford to, switch to an electric car if you need to drive.
The campaign to make all of inner London (not just central London) an ULEZ could dramatically improve air quality. Woodcock found that if most trips were walked or cycled (as is the case in parts of Holland) particulate matter would be reduced by a third.
At the individual level, the most obvious, zero cost solution to poor air quality is to avoid the roads where it's worst. Several studies confirm that route choice influences exposure to pollutants.
The difference in air quality between the worst and best streets in London is enormous, ranging from 'unhealthy' to 'good' on the same day at the same time. You can check the relative ratings of routes and streets on the King's College London air quality map (londonair.org.uk) or AQI international map (aqicn.org) on a 'live' or annual basis. While London rates poorly in the European context, look up Delhi or Beijing on the AQI map to see how unchecked traffic growth can reduce air quality to levels that are often described as 'hazardous'.
In London you can assume that most A-roads will be over the EU limit (annual mean objective) for pollutants, as will some inner city B-roads. Even minor streets in the Square Mile exceed the limits for NO2, but minor roads in the rest of inner London are at, or close to, meeting the annual objectives. Beyond inner London generally you are cycling on roads marked in green (below EU limits) on the King's College map.
Using routes through parks obviously helps reduce your pollutant intake and avoiding roads with HGVs and buses helps avoids the worst of the diesel emissions. If you can't avoid major roads, choose those with cycle tracks away from the traffic stream. The King's College map takes into account factors such as topography and building design as well as vehicle volumes.
Timing can also minimise exposure. If you have the opportunity to avoid rush hours you can miss the worst of the exhaust fumes.
There are also specific days when pollution levels are higher in London. They don't reach the Beijing 'airpocalypse' levels of AQIs beyond 400, but can still reach an AQI of 150 - three times recommended levels.
Taking a longer but 'cleaner' route on such days could reduce your exposure.
Face masks of various types are used by some cyclists. Better masks are usually certified to a standard such as N95 indicating the percentage of particles (whether PM10 or PM 2.5) they eliminate. But how effective are they?
An academic study in Beijing (Langrish et al) found that, under test conditions, a single-use 3M industrial dust respirator mask did reduce the intake of particle pollutants (not gases like N02) when used by walkers and helped reduce negative effects of pollution on blood pressure and heart rate variability. However the researchers' initial testing of a range of masks also found that the four cycling masks they tested (% penetrance of 11 and above) did not provide the same level of protection as the single-use industrial dust mask (% penetrance of 3.4). We are not aware of academic studies that fully test cycle-specific masks.
What is clear is that poorly-fitting masks reduce their effectiveness. 'They're better than nothing, but they're hard to breathe through during vigorous exercise,' says Mandy Dryer, a respiratory physiotherapist at the Manchester Royal Infirmary. 'All too often the seal around your mouth and nose isn't air-tight, so you end up sucking in unfiltered air through a gap and don't push yourself as hard, so you don't get the fitness benefits of cycling.
Getting a secure and comfortable fit is no easy matter. Any facial hair or stubble can create extra gaps, as can a mask in the wrong size or without secure coverage of the nose. So always follow manufacturer instructions and try as many as you can.


text:
Editorial: Improving AP exams
The Red Ledger Staff|March 2, 2021
Jordan Ruppert
Many teachers have adapted their teaching with the unpredictability of the year, and The College Board should be sensitive to these changes.
The College Board announced on Jan. 12 that schools were given the option to administer online, in person or a mix of the two testing options. Tests will be full length and cover the full-year curriculum, except for AP Physics I missing two units.
The College Board failed to standardize AP exams in ways that allow students to succeed and should administer exams in means that are favorable to students.
The choice of whether to take exams online or in person should be given to students, not schools' AP coordinators. This will allow students to choose which testing option will benefit them the most. Currently, online exams will not test material that students can search online, and students will not be able to move back and forth between questions. Online and in-person exams have advantages and disadvantages that students should consider when deciding which option to choose. If students and parents had the choice to decide whether to attend school in person or not, they should have the same choice for exams. Ultimately, this choice should be given to the students, not the schools.
Each online and in-person exam administration and test version should be scored individually to ensure that students are scored based on the scores of those who took the same test in the same testing setting. With multiple testing dates and options of paper, online, at-school and at-home testing, the College Board should score individually. With past years' tests being administered on one date, with one test version, it makes sense to score all tests accordingly and on the same scale, but with different testing circumstances, the means of testing needs to change in order to ensure that students' scores are as accurate and fair to their testing situation as possible. Students who plan to take their exams in person in May have vocalized their concern with being scored against students who take their exams at home, online, a month later, in June.
Currently, the College Board has released that all exams will cover the full courses' curriculum and will be full length exams, per usual. Last year, they made changes to the exam to make them shorter and only cover certain topics because of the circumstances with COVID-19. With this school year being just as unusual with hybrid learning and teaching via videos and zoom, the College Board should adapt their exams similarly. Many teachers have adapted their teaching with the unpredictability of the year, and The College Board should be sensitive to these changes. Technical difficulties need to be addressed when considering how much content to cover. In addition to a change in content, exams should be shortened as well. Less material and partial length tests will benefit students. Extra time should be given to accommodate for technical issues, but exams should be shortened overall.
While the College Board claims that their testing changes "prioritize the health and safety of educators and students," it failed to accommodate the extreme and unusual conditions that students and teachers face this school year. Ultimately, students should have the choice to test online or in person. If the College Board shortened their exam content and exams and scored them individually, it would benefit students and give them the best opportunity to demonstrate their knowledge despite the abnormal circumstances of the past year.
The Red Ledger Staff
Jordan Ruppert, Graphic Designer
This is sophomore Jordan Ruppert's second year on staff doing graphics for The Red Ledger. Jordan was in photography in middle school and enjoys being...
Editorial: Reintroducing college and career counseling position
Editorial: Continuing block schedule
Editorial: Testing on the same playing field
Editorial: Tolerant policies for interactive learning
Editorial: Building maturity through confusion, fear
Column: A beautiful mind
Column: Allegiance
Column: Jar of blessings
Heed the holidays
Editorial: Removing B lunch for learning, efficiency, safety
Editorial: Reducing problems and renewing habits
Editorial: Practice punctuality
Ed-emojis: End of the year, allergies, rain and more
Editorial: Standing up for Student Press Freedom Day

redpajama_set_name: RedPajamaCommonCrawl


text:
Congregational Church, Franklin – Jerry Dougherty
Originally called West Farms, the town of Franklin in the New London County hills of east-central Connecticut separated from Norwich and incorporated in 1786. It took its new name in honor of Benjamin Franklin. Through the years, agriculture along with small industry and business has constituted the community's economic base. Town notables include Uriah Tracy, the first member of Congress to be buried in the Congressional Cemetery in the nation's capital, and Dr. Ashbel Woodward, a Union surgeon during the Civil War whose home is now a museum. Today, Franklin is part of The Last Green Valley, a 35-town National Heritage Corridor preserving rural culture and natural resources.
Uriah Tracy Authors the Rules for Impeachment
Uriah Tracy was an attorney and politician who took up... …[more]
"The Last Green Valley," 2017. Link.
FranklinCT.com. "Franklin Historical Society," 2013. Link.
Connecticut State Library Digital Collections. "Franklin - WPA Architectural Survey," 2016. Link.
"Franklin Collection." Connecticut Digital Archive, n.d. Link.
Woodward, Ashbel. A Historical Address: Delivered in Franklin, Connecticut, October 14th, 1868, on the Two Hundredth Anniversary of the Settlement of the Town, and the One Hundred and Fiftieth Anniversary of Its Ecclesiastical Organizations. New Haven, CT: Tuttle, Morehouse & Taylor, Printers, 1870. Link.
Marshall, Benjamin Tinkham, ed. A Modern History of New London County, Connecticut. Vol. 1. New York, NY: Lewis Historical Publishing Company, 1922. Link.
Robbins, Marjorie. Franklin Bicentennial History, 1786-1986. Franklin, CT: Bicentennial Committee, 1986.
Connecticut Historical Commission, and Geoffrey Rossano. Historic and Architectural Resource Survey of the Town of Franklin, Connecticut. Hartford, CT: Connecticut Historical Commission, 2002.
Find Franklin
A Baltic Mill Helps Found a New Town
Over Time: Franklin's Historical Population
More about Franklin


In an attempt to reduce the number of employer-employee lawsuits, each state employs their version of a workers' compensation system. Under workers' compensation, employees are entitled to financial benefits if they are injured while performing their job duties. In exchange for these guaranteed benefits, they agree not to sue their employer if an injury occurs.
Unfortunately, this system doesn't always work correctly, and legitimate claims are denied. If this happens, you need the help of RP Law Group to collect the compensation to which you are entitled.
If your workers' compensation claim was denied unfairly, all hope is not lost. If you trust your employer to help you with this issue, you may approach them first and ask for help appealing to their insurance provider. However, if you suspect that your claim was denied in an attempt to keep costs down, your next call should be to RP Law Group.
We will help you submit an official appeal to the appropriate state agency and handle all negotiations with your employer, their insurance carrier, or both. If those avenues prove unsuccessful, we can take your employer to court and battle the matter out there. No matter what, we have your back and will not give up until we secure the compensation you deserve.
RP Law Group helps employees who have suffered workplace injuries collect compensation after their claim has been denied. If your employer's insurance provider rejects your valid claim, contact our experienced Riverside and Inland Empire workplace injury attorney today at (951) 394-3640 to get help.


Our lensmen snapped Shraddha Kapoor leaving the Mumbai airport with father Shakti Kapoor. Shraddha was all smiles while Shakti didn't look amused to see our shutterbugs. The father-daughter duo was returning from a family friend's wedding. Shraddha rushed back from the celebrations to begin shooting for her next film, Haseena.


24 A dispute also arose among them as to which one of them was to be regarded as the greatest. 25 But he said to them, "The kings of the Gentiles lord it over them; and those in authority over them are called benefactors. 26 But not so with you; rather the greatest among you must become like the youngest, and the leader like one who serves. 27 For who is greater, the one who is at the table or the one who serves? Is it not the one at the table? But I am among you as one who serves.
I remember (many years ago now) eating lunch with Taylor at her school during National School Lunch Week. Taylor was in the second grade at the time. We lined up with her class and walked to the cafeteria in a single file line to receive our tacos and burritos on school lunch plates sitting atop the brightly colored cafeteria trays. Beverly and I sat in tiny little chairs with our knees bumping the bottom of the tables. There's nothing like eating in an acoustically live room with a bunch of second and third graders!
After the meal, we lined up to dispose of our leftovers and trash. Paper products went into one can and leftover food went into another. We handed over our silverware and compartmentalized plate to be scrubbed, washed, and disinfected by a giant stainless steel commercial dishwasher. We then lined up single file again to be led back to the classroom where the parents were dismissed.
While standing in line one of Taylor's classmates looked at me and asked, "Are you Taylor's dad?" "Yes I am," I replied. "Were you there when Taylor got stitches in her knee?" (Taylor had fallen at a church choir picnic requiring stitches). "Did she cry?" "No she didn't," I said. "Did you buy her a present?" "Why do you ask?" I inquired. "Well, you're supposed to buy us presents when we're good."
And the disciples being envious of one another and desiring a position of power asked Jesus, "What is our award for being faithful disciples? Who among us will sit on your right and who will sit on the left?" Unfortunately, our lives are often shaped by envy and the expectation of reward. As disciples of Jesus, our lives are better shaped by wanting what we need-the grace of God in Jesus Christ. There is no joy or benefit in envy. As William Arthur Ward once said, "Blessed is he who has learned to admire but not envy, to follow but not imitate, to praise but not flatter, and to lead but not manipulate."
Envy is the child of hate, by implication, to Envy our neighbors goods is not only to despise ourselves but also to despise God. To regard our lives as diminished, in comparison with our neighbor's life, is to despise the God who gave us our lives as they are. It is to say that God made a mistake in making us as we are, in giving us the gifts that we have been given, and by implication, in making our neighbor and giving our neighbor the gifts that have been given.
Be grateful for who you are as a child of God. Be grateful for your friends and neighbors and the gifts they have. Will you sell your soul to envy or fill your life with gratitude for all that God has done for you? Think about it.


Robert W. Decker, MD, earned his undergraduate degree and a master's in molecular biology at University of California, Los Angeles (UCLA). He then completed medical school at University of California, Davis, where he graduated with high honors. Dr. Decker returned to Los Angeles for his internship and residency, including serving as chief resident, at Cedars-Sinai Medical Center. He completed fellowship training in hematology and oncology at the UCLA Medical Center. During his fellowship, Dr. Decker obtained special training in bone marrow transplantation and the treatment of leukemia.
Dr. Decker entered private practice in 1987 with the medical group that eventually became Tower Hematology Oncology Medical Group. He also co-founded the Bone Marrow and Stem Cell Transplantation Program at Cedars-Sinai. As well, Dr. Decker has been an active member of the hospital staff, holding several important positions and committee chairmanships and participating in the training of medical residents, and has authored numerous scientific publications. Dr. Decker is an active member of the American Society of Oncology, the American College of Physicians, and the Southern California Academy of Clinical Oncology.
Outside of his busy career, Dr. Decker enjoys an active family life. He and his wife are very proud of their three sons, two of whom have attended UC Berkeley (as his wife did) and his middle son graduated Columbia University. He enjoys playing golf in his free time and has an avid interest in baseball and sports memorabilia.


While watching the attached video I started thinking about how telemark technique has evolved over the years.....or has it? The movie shows some great skiers from the 90's on floppy gear in very challenging conditions. Would they look different in 2017? if so, why and how?
There is no question that we had to work a lot harder for the turns on that gear. Those skiers on todays gear (big boots and especially fat rockered skis) would have cruised through the gnarly stuff whereas they were jumping and pumping on the skinnies.
I bet if you could find the guys in that video now they would be looking effortless while railing a 50 degree headwall on new school gear.
So I think that was my point....that what made great tele skiers back then is not really different from what makes them (not us) great today. With all the talk about evolving technique and the new gear, the core components of a good tele turn haven't really changed. I think the difference is that what they were doing was really hard and demanded not only sick athletic skills but the vision and guts to commit to lines that would incapacitate mere mortals (us). The new gear helps modern skiers physically and the way it is now taught adds structure to what once was done purely by instinct.


We are seeking to recruit a Postdoctoral Researcher to work in the `Autonomy and Verification Lab at the University of Liverpool. You will carry out research centred on autonomy and verification, potentially involving work across formal verification, agent theory, agent programming, assurance of deep/reinforcement learning, testing, robot software architectures, or security analysis. The work will likely involve collaboration across a range of universities, disciplines, and industrial partners. You should have a PhD in Computer Science, Mathematics or a related discipline. The post is available immediately, continuing until 31 March 2021.


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Here are some featured rweb design, web marketing, and ad agency firms, goods, and services companies in and around Calgary.
We are a Calgary web design, development, and web site promotion company doing business throughout Alberta and across Canada.
Ad Agency or Web DesignerBlindDrop Design Inc.
BlindDrop Design Inc. is a full service internet marketing agency serving Cochrane, Calgary and surrounding area. From a digital marketing strategy, branding, web hosting, custom WordPress design and development, Social Media and SEO services.
Outsource Ink specializes in Virtual Business Management and Transcription. By outsourcing you lighten your work load and are able to focus on what it is you do best in business. Do what you do best, and outsource the rest!
Here are some featured radio and television stations, newspapers, and magazines in and around Calgary.
Entertainment guide for Calgary. Find Calgary Events, Calgary Movies, Wing Nights, Attractions and much more.
RenoLink is an online directory helping Calgary homeowners find, qualify and select top contractors and renovators with ease. Explore renovator profiles, read consumer reviews, view photos of contractors' work and get free online estimates.
We provide full lifecylce management to help find the right solution. Vannin works with all major components of a project from RFP generation, designing the solution to meet your requirements, implementation, right through to post production support.
Get your promotional message noticed, engage the interest of your audience and generate results with unique event and sponsorship tactics - outdoor event graphics, golf cart path graphics, promo giveaways and out of home speciality advertising.
Here are some featured communications products & services companies in and around Calgary.
Music Productions, Recording, Mixing, Mastering, Live Music.
Wonderful, heartwarming and sensitive family and personal portraits for you and your loved ones. As well, we provide maternity, baby, newborn, children and grad portrait sessions. We are pet friendly.


text:
Q: Format MySQL timestamp to ics format I am trying to convert some MySQL timestamps to the official .ics format. Unfortunately, I always get the output "19700101T013334Z".
MySQL format: 2014-09-29 18:00:00
This is my PHP function, that should convert the dates accordingly:
function dateToCal($timestamp) {
    return date('Ymd\THis\Z', $timestamp);
}

What am I doing wrong?

A: date() expects a Unix timestamp as the second parameter. You can use strtotime() to convert $timestamp to a Unix timestamp for you.
function dateToCal($timestamp) {
    return date('Ymd\THis\Z', strtotime($timestamp));
}

It might be easier, and better, if you converted that date to a Unix timestamp in your query using UNIX_TIMESTAMP().

A: I know you've already got an answer, but you can also do this in the database:
SELECT FORMAT_DATE("2014-09-29 18:00:00", "%Y%m%dT%H%i%sZ");
The Z at the end indicates UTC so if you're storing your dates using system time you'll want to convert that as well.

A: You have to convert MySql's datetime to a Unix timestamp befor you can use it -
function dateToCal($timestamp) {
    date('Ymd\THis', strtotime($timestamp));
}

You really do not have to have the \Z in the function.


text:
Dhanshika in Dhanush's film
Actress Dhanshika, who was last seen in Vasanthabalan's Aravaan is part of Edhir Neechal to be produced by actor Dhanush's Wunderbar Films. She plays a sports coach in the film.
The film, directed by Senthil, a former assistant to Vetri Maaran, has a sports backdrop. Dhanshika will be Siva Karthikeyan's coach. Kolaveri music director Anirudh is scoring the music.
Priya Anand plays the heroine. Dhanishka is delighted to be part of the crew.
dhansika in dhanush production dhanush next film priya anand opposite dhanush	2012-07-12


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text:
Руда Буква је насеље у Србији у општини Косјерић у Златиборском округу. Према попису из 2011. било је 95 становника.

Демографија
У насељу Руда Буква живи 106 пунолетних становника, а просечна старост становништва износи 51,1 година (50,2 код мушкараца и 52,1 код жена). У насељу има 41 домаћинство, а просечан број чланова по домаћинству је 2,88.

Ово насеље је у потпуности насељено Србима (према попису из 2002. године).

Референце

Спољашње везе

 Мапе, аеродроми и временска ситуација локација (-{Fallingrain}-)
 Гугл сателитска мапа (-{Maplandia}-)

Насељена места у Златиборском управном округу
Википројект географија/Насеља у Србији
Насељена места у Косјерићу

redpajama_set_name: RedPajamaWikipedia


text:
RNA-Guided Human Genome Engineering via Cas9
Prashant Mali1,*,
Luhan Yang1,3,*,
Kevin M. Esvelt2,
John Aach1,
Marc Guell1,
James E. DiCarlo4,
Julie E. Norville1,
George M. Church1,2,†
1Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
2Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02138, USA.
3Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA 02115, USA.
4Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
↵†To whom correspondence should be addressed. E-mail: gchurch{at}genetics.med.harvard.edu
Science 15 Feb 2013:
Vol. 339, Issue 6121, pp. 823-826
Prashant Mali
Luhan Yang
Kevin M. Esvelt
John Aach
Marc Guell
James E. DiCarlo
Julie E. Norville
George M. Church
For correspondence: gchurch@genetics.med.harvard.edu
Bacteria and archaea have evolved adaptive immune defenses, termed clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems, that use short RNA to direct degradation of foreign nucleic acids. Here, we engineer the type II bacterial CRISPR system to function with custom guide RNA (gRNA) in human cells. For the endogenous AAVS1 locus, we obtained targeting rates of 10 to 25% in 293T cells, 13 to 8% in K562 cells, and 2 to 4% in induced pluripotent stem cells. We show that this process relies on CRISPR components; is sequence-specific; and, upon simultaneous introduction of multiple gRNAs, can effect multiplex editing of target loci. We also compute a genome-wide resource of ~190 K unique gRNAs targeting ~40.5% of human exons. Our results establish an RNA-guided editing tool for facile, robust, and multiplexable human genome engineering.
Bacterial and archaeal clustered regularly interspaced short palindromic repeats (CRISPR) systems rely on CRISPR RNAs (crRNAs) in complex with CRISPR-associated (Cas) proteins to direct degradation of complementary sequences present within invading viral and plasmid DNA (1–3). A recent in vitro reconstitution of the Streptococcus pyogenes type II CRISPR system demonstrated that crRNA fused to a normally trans-encoded tracrRNA is sufficient to direct Cas9 protein to sequence-specifically cleave target DNA sequences matching the crRNA (4). The fully defined nature of this two-component system suggested that it might function in the cells of eukaryotic organisms such as yeast, plants, and even mammals. By cleaving genomic sequences targeted by RNA sequences (4–6), such a system could greatly enhance the ease of genome engineering.
Here, we engineer the protein and RNA components of this bacterial type II CRISPR system in human cells. We began by synthesizing a human codon–optimized version of the Cas9 protein bearing a C-terminal SV40 nuclear localization signal and cloning it into a mammalian expression system (Fig. 1A and fig. S1A). To direct Cas9 to cleave sequences of interest, we expressed crRNA-tracrRNA fusion transcripts, hereafter referred to as guide RNAs (gRNAs), from the human U6 polymerase III promoter. Directly transcribing gRNAs allowed us to avoid reconstituting the RNA-processing machinery used by bacterial CRISPR systems (Fig. 1A and fig. S1B) (4, 7–9). Constrained only by U6 transcription initiating with G and the requirement for the PAM (protospacer-adjacent motif) sequence -NGG following the 20–base pair (bp) crRNA target, our highly versatile approach can, in principle, target any genomic site of the form GN20GG (fig. S1C; see supplementary text S1 for a detailed discussion).
Genome editing in human cells using an engineered type II CRISPR system. (A) RNA-guided gene targeting in human cells involves coexpression of the Cas9 protein bearing a C-terminal SV40 nuclear localization signal (NLS) with one or more gRNAs expressed from the human U6 polymerase III promoter. Cas9 unwinds the DNA duplex and cleaves both strands upon recognition of a target sequence by the gRNA, but only if the correct PAM is present at the 3′ end. Any genomic sequence of the form GN20GG can, in principle, be targeted. CMV, cytomegalovirus promoter; TK, thymidine kinase; pA, polyadenylation signal. (B) A genomically integrated GFP coding sequence is disrupted by the insertion of a stop codon and a 68-bp genomic fragment from the AAVS1 locus. Restoration of the GFP sequence by HR with an appropriate donor sequence results in GFP+ cells that can be quantified by FACS. T1 and T2 gRNAs target sequences within the AAVS1 fragment. Binding sites for the two halves of the TALEN are underlined. (C) Bar graph depicting HR efficiencies induced by T1, T2, and TALEN-mediated nuclease activity at the target locus, as measured by FACS. Representative FACS plots and microscopy images of the targeted cells are depicted below. (Scale bar, 100 μm.) Data are shown as means ± SEM (N = 3).
To test the functionality of our implementation for genome engineering, we developed a green fluorescent protein (GFP) reporter assay (Fig. 1B) in human embryonic kidney HEK 293T cells similar to one previously described (10). Specifically, we established a stable cell line bearing a genomically integrated GFP coding sequence disrupted by the insertion of a stop codon and a 68-bp genomic fragment from the AAVS1 locus that renders the expressed protein fragment nonfluorescent. Homologous recombination (HR) using an appropriate repair donor can restore the normal GFP sequence, which enabled us to quantify the resulting GFP+ cells by flow-activated cell sorting (FACS).
To test the efficiency of our system at stimulating HR, we constructed two gRNAs, T1 and T2, that target the intervening AAVS1 fragment (Fig. 1B) and compared their activity to that of a previously described TAL effector nuclease heterodimer (TALEN) targeting the same region (11). We observed successful HR events using all three targeting reagents, with gene correction rates using the T1 and T2 gRNAs approaching 3% and 8%, respectively (Fig. 1C). This RNA-mediated editing process was notably rapid, with the first detectable GFP+ cells appearing ~20 hours post transfection compared with ~40 hours for the AAVS1 TALENs. We observed HR only upon simultaneous introduction of the repair donor, Cas9 protein, and gRNA, which confirmed that all components are required for genome editing (fig. S2). Although we noted no apparent toxicity associated with Cas9/gRNA expression, work with zinc finger nucleases (ZFNs) and TALENs has shown that nicking only one strand further reduces toxicity. Accordingly, we also tested a Cas9D10A mutant that is known to function as a nickase in vitro, which yielded similar HR but lower nonhomologous end joining (NHEJ) rates (fig. S3) (4, 5). Consistent with (4), in which a related Cas9 protein is shown to cut both strands 3 bp upstream of the PAM, our NHEJ data confirmed that most deletions or insertions occurred at the 3′ end of the target sequence (fig. S3B). We also confirmed that mutating the target genomic site prevents the gRNA from effecting HR at that locus, which demonstrates that CRISPR-mediated genome editing is sequence-specific (fig. S4). Finally, we showed that two gRNAs targeting sites in the GFP gene, and also three additional gRNAs targeting fragments from homologous regions of the DNA methyl transferase 3a (DNMT3a) and DNMT3b genes could sequence-specifically induce significant HR in the engineered reporter cell lines (figs. S5 and S6). Together, these results confirm that RNA-guided genome targeting in human cells is simple to execute and induces robust HR across multiple target sites.
Having successfully targeted an integrated reporter, we next turned to modifying a native locus. We used the gRNAs described above to target the AAVS1 locus located in the PPP1R12C gene on chromosome 19, which is ubiquitously expressed across most tissues (Fig. 2A). We targeted 293Ts, human chronic myelogenous leukemia K562 cells, and PGP1 human induced pluripotent stem (iPS) cells (12) and analyzed the results by next-generation sequencing of the targeted locus. Consistent with our results for the GFP reporter assay, we observed high numbers of NHEJ events at the endogenous locus for all three cell types. The two gRNAs T1 and T2 achieved NHEJ rates of 10 and 25% in 293Ts, 13 and 38% in K562s, and 2 and 4% in PGP1-iPS cells, respectively (Fig. 2B). We observed no overt toxicity from the Cas9 and gRNA expression required to induce NHEJ in any of these cell types. As expected, NHEJ-mediated deletions for T1 and T2 were centered around the target site positions, which further validated the sequence-specificity of this targeting process (figs. S7 to S9). Simultaneous introduction of both T1 and T2 gRNAs resulted in high-efficiency deletion of the intervening 19-bp fragment (fig. S8), which demonstrated that multiplexed editing of genomic loci is feasible using this approach.
RNA-guided genome editing of the native AAVS1 locus in multiple cell types. (A) T1 (red) and T2 (green) gRNAs target sequences in an intron of the PPP1R12C gene within the chromosome 19 AAVS1 locus. (B) Total count and location of deletions caused by NHEJ in 293Ts, K562s, and PGP1 iPS cells after expression of Cas9 and either T1 or T2 gRNAs as quantified by next-generation sequencing. Red and green dashed lines demarcate the boundaries of the T1 and T2 gRNA targeting sites. NHEJ frequencies for T1 and T2 gRNAs were 10% and 25% in 293T, 13% and 38% in K562, and 2% and 4% in PGP1 iPS cells, respectively. (C) DNA donor architecture for HR at the AAVS1 locus, and the locations of sequencing primers (arrows) for detecting successful targeted events, are depicted. (D) PCR assay 3 days after transfection demonstrates that only cells expressing the donor, Cas9 and T2 gRNA exhibit successful HR events. (E) Successful HR was confirmed by Sanger sequencing of the PCR amplicon, which showed that the expected DNA bases at both the genome-donor and donor-insert boundaries are present. (F) Successfully targeted clones of 293T cells were selected with puromycin for 2 weeks. Microscope images of two representative GFP+ clones is shown. (Scale bar, 100 μm.)
Last, we attempted to use HR to integrate either a double-stranded DNA donor construct (13) or an oligo donor into the native AAVS1 locus (Fig. 2C and fig. S10). We confirmed HR-mediated integration, using both approaches, by polymerase chain reaction (PCR) (Fig. 2D and fig. S10) and Sanger sequencing (Fig. 2E). We also readily derived 293T or iPS clones from the pool of modified cells using puromycin selection over 2 weeks (Fig. 2F and fig. S10). These results demonstrate that this approach enables efficient integration of foreign DNA at endogenous loci in human cells.
Our versatile RNA-guided genome-editing system can be readily adapted to modify other genomic sites by simply modifying the sequence of our gRNA expression vector to match a compatible sequence in the locus of interest. To facilitate this process, we bioinformatically generated ~190,000 specific gRNA-targetable sequences targeting ~40.5% exons of genes in the human genome (refer to methods and table S1). We also incorporated these target sequences into a 200-bp format compatible with multiplex synthesis on DNA arrays (14) (fig. S11 and tables S2 and S3). This resource provides a ready genome-wide reference of potential target sites in the human genome and a methodology for multiplex gRNA synthesis.
Our results demonstrate the promise of CRISPR-mediated gene targeting for RNA-guided, robust, and multiplexable mammalian genome engineering. The ease of retargeting our system to modify genomic sequences greatly exceeds that of comparable ZFNs and TALENs, while offering similar or greater efficiencies (4). Existing studies of type II CRISPR specificity (4) suggest that target sites must perfectly match the PAM sequence NGG and the 8- to 12-base "seed sequence" at the 3′ end of the gRNA. The importance of the remaining 8 to 12 bases is less well understood and may depend on the binding strength of the matching gRNAs or on the inherent tolerance of Cas9 itself. Indeed, Cas9 will tolerate single mismatches at the 5′ end in bacteria and in vitro, which suggests that the 5′ G is not required. Moreover, it is likely that the target locus's underlying chromatin structure and epigenetic state will also affect the efficiency of genome editing in eukaryotic cells (13), although we suspect that Cas9's helicase activity may render it more robust to these factors, but this remains to be evaluated. Elucidating the frequency and underlying causes of off-target nuclease activity (15, 16) induced by CRISPR, ZFN (17, 18), and TALEN (19, 20) genome-engineering tools will be of utmost importance for safe genome modification and perhaps for gene therapy. Potential avenues for improving CRISPR specificity include evaluating Cas9 homologs identified through bioinformatics and directed evolution of these nucleases toward higher specificity. Similarly, the range of CRISPR-targetable sequences could be expanded through the use of homologs with different PAM requirements (9) or by directed evolution. Finally, inactivating one of the Cas9 nuclease domains increases the ratio of HR to NHEJ and may reduce toxicity (figs. S1A and fig. S3) (4, 5), whereas inactivating both domains may enable Cas9 to function as a retargetable DNA binding protein. As we explore these areas, we note that another parallel study (21) has independently confirmed the high efficiency of CRISPR-mediated gene targeting in mammalian cell lines. We expect that RNA-guided genome targeting will have broad implications for synthetic biology (22, 23), the direct and multiplexed perturbation of gene networks (13, 24), and targeted ex vivo (25–27) and in vivo gene therapy (28).
www.sciencemag.org/cgi/content/full/science.1232033/DC1
Supplementary Text
Figs. S1 to S11
References (29–46)
B. Wiedenheft,
S. H. Sternberg,
J. A. Doudna
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Acknowledgments: This work was supported by NIH grant P50 HG005550. We thank S. Kosuri for advice on the oligonucleotide pool designs and synthesis. G.M.C. and P.M. have filed a patent based on the findings of this study.
You are going to email the following RNA-Guided Human Genome Engineering via Cas9
By Prashant Mali, Luhan Yang, Kevin M. Esvelt, John Aach, Marc Guell, James E. DiCarlo, Julie E. Norville, George M. Church
Science 15 Feb 2013 : 823-826
A bacterial genome defense system is adapted to function as a genome-editing tool in mammalian cells. [Also see Perspective by van der Oost]


Oporto is of outstanding universal value as the urban fabric and its many historic buildings bear remarkable testimony to the development over the past 1,000 years of a European city that looks outward to the West for its cultural and commercial links.
There has been human occupation on the site of modern Oporto, at the mouth of the Douro River, since the 8th century BC. There the Romans established a town under the name of Portus. With the arrival in the early 5th century of the barbarians, the town became very important as an administrative and trading centre. By the early 11th century, it was firmly established as part of the Castilian realm. The first period of expansion came with the construction in 1374 of a new town wall protecting the two urban nuclei - the original medieval town and the hitherto extramural harbour area.
Oporto lent support to the expeditions organized by Henry the Navigator (who was born in the town) in the early 15th century. English entrepreneurs invested in the vineyards of the Douro valley, to supply the huge English market, and Oporto, as the port for the export of these wines, benefited greatly, as the wealth of Baroque buildings in the town attests. The citizens reacted against Pombal's creation of the Companhia do Alto Douro, designed to end the English monopoly. Oporto was the birthplace of the Liberal Revolution in 1820, which led to the adoption by the monarchy of the Seminal Constitution of 1822. During the 19th century, the town centre moved from the banks of the river to the new developments around the Praça da Liberdade: Gustav Eiffel designed the railway bridge across the river (1875), and many new buildings were constructed.
The historic centre is enclosed within the enceinte of the 14th-century Fernandine walls, together with some smaller areas that retain their medieval characteristics. This area conserves to a large extent the medieval town plan and urban fabric, with some later monumental insertions. Remains of the 12th-century ramparts that survive in place were erected on Roman foundations. Only two sections of the Fernandine walls, initiated by Dom Afonso IV in 1336 but named after his successor, Dom Fernando, in whose reign they were completed in 1376, are still standing. The massive crenellated stone walls were strengthened with many bastions and square towers. In this area there are many important ecclesiastical building, such as the Romanesque core of the cathedral. Among the many fine Gothic churches are São Francisco, São Lourenço dos Grillos, in the Mannerist style, Santa Clara in the Gothic Manueline style with later classical Renaissance elements, Nossa Senhora da Vitória, the early Baroque lgreja da Misericórdia, and lgreja dos Clérigos of NiccolòNazzoni. Oporto also has a number of outstanding public buildings: the São João Theatre, the Palácio da Batalha, the Palácio das Sereias and the former Prison da Relação. Among the important later structures are the neo-Palladian Hospital Sant'António, the imposing Alfándega, and the Palace da Bolsa in neoclassical style, the Ferreira Borges Market, the São Bento railway station and the Paços do Concelho.


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How Shaquille O'Neal Scored an Invitation to Ex-Wife Shaunie's Wedding
To score an invite to Shaunie Henderson's wedding, you may need to jump through some hoops.
Close to six months after the Basketball Wives star married Pastor Keion Henderson in a fairytale wedding, the couple is ready to document their road to the altar for a new VH1 special titled Shaunie & Keion's Destination "I Do."
Along the way, viewers will find out who was able to score an invite, including Shaunie's ex-husband Shaquille O'Neal.
"My daughter had her sweet 16," Shaunie shared with E! News in an exclusive interview. "She turned 16 in May right before the wedding so we were at the birthday party together and he's like, 'Well, am I invited to the wedding?' And I was like, 'Of course you are.' And I'm rolling my eyes like, 'I mean you are, but do you really have to come?' But I mean, that's our banter, right? I know people will take that and run with it. But that's been our banter."
According to Shaunie, the former NBA player really wasn't coming, "but he got the courtesy invite."
Related Topics:Entertainmentex-wifehowinvitationo'nealscoredshaquilleshaunie'swedding
Kate Hudson Details Parenting With Exes Matt Bellamy & Chris Robinson
The White Lotus Actors Give Their Reaction to That Scene
This is from Kendall Jenner's Moon collab. Keep this with you, so you can whiten your teeth at any time and make a dazzling impression. The brand claims that you can "take your look to a new level within just 30 seconds of that first use."
An Amazon customer raved, "I love owning a product that I can depend on every single day to make my smile appearance 110% better. My smile is the most important feature on my face. I talk to people every single day as part of my job. In the morning before work I am always on the go. When using the Moon Whitening Pen it was easy to use. Quick to dry and instant results. I didn't have to wait more than 30 seconds to see that my smile was Whiter than it was before applying the Moon gel. I can keep it in my lunch bag, purse and pretty much carry it with me in my pocket if I needed to."
A shopper reviewed, "This whitening pen is pretty impressive. I've added it into my nightly routine & have whiter teeth & no sensitivity at all!"
We independently selected these products because we love them, and we think you might like them at these prices. E! has affiliate relationships, so we may get a commission if you purchase something through our links. Items are sold by the retailer, not E!. Prices are accurate as of publish time.
Aesthetically pleasing can mean a lot of different things depending on what your personal preferences are— from cute and chic to retro and cool, there are so many things that can fit under the definition of "aesthetic."
Nonetheless, no matter your vibe, if an item is "aesthetically pleasing," it means it's nice to look at, elevates the rest of the space it's in and tickles a part of your brain that makes you want to immediately click "Add To Cart." Maybe that last one is just me. But as someone who loves to shop, the final additional criteria an aesthetically pleasing product has to fulfill before I actually buy it is that it has to be as functional as it is cute.
After scouring the depths of the interweb, I've rounded up the best items that can fit with any aesthetic and are as useful as they are pretty to look at. From your kitchen to your living room and bedroom, these items will be sure to elevate your entire space so you feel like the main character every day.
It was an unforgettable night at the Wade household.
Zaya Wade recently attended her winter formal, and, of course, dad Dwyane Wade and stepmom Gabrielle Union were there to help celebrate and document the occasion.
"Winter Formal," the athlete and the actress wrote in a joint Instagram post Jan. 29 alongside a series of photos and videos of their 15-year-old daughter ahead of the event. "Supporting each other for life's big moments is key. All the nerves, all the anxiety, all the fear…With loved ones by your side, no matter the challenge, we 10 toes down. Always."
For the dance, Zaya wore a sequin column gown with a tulle bolero from Rodarte's Fall 2022 collection and accessorized her look with a sparkly necklace and coordinating clutch. Thomas Christos Kikis styled her, and Malika James applied her makeup. Alexander Armand also did Zaya's hair, noting on Instagram they decided to go with "soft blowout curls to compliment the Ethereal Essence."


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EagleBet first hit our screens in July 2019. Despite being a relative newcomer, it's a bookmaker with plenty of positives and is already proving to be a hit with sports betting fans throughout Europe. It is clear that a lot of thought has gone into providing the best possible user experience, and the firm uses talented web developers to deliver a smooth, streamlined gambling experience to all its customers.
Is EagleBet trustworthy?
EagleBet currently holds a licence with the Malta Gaming Authority, which is proof that it can be trusted to offer fairness and transparency. Users can also rest assured that their winnings will be protected and that all personal data is encrypted.
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From the most popular events like the Bundesliga and English Premier League to more niche sports like curling, EagleBet has got it all covered. It's easy to create accumulators by combining different sporting events too. Whether you're a horse racing aficionado, a fan of boxing or a motorsports enthusiast, you'll be able to bet on all the latest sports action at EagleBet. While the brand currently doesn't offer live streaming, there are plenty of in-play live stats which are updated in real-time to allow users to keep up with the latest changes and make informed decisions on where to place their next in-play bet.
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Let's face it; the sportsbook betting marketplace is incredibly crowded these days. To attract new users, bookmakers need to offer great-value odds – and that's precisely what EagleBet does. With regular promotions and odd-boosts available, it's hard to find better odds online. The in-play section offers particularly competitive odds, with a 94% payout ratio. In addition to great odds, EagleBet also provides lots of different types of bets, like "next goal", "winner for the rest of the match" and "number of yellow cards in a match".
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EagleBet is one of the most reliable European bookmakers for withdrawals and deposits. It places a minimum deposit/withdrawal restriction of €10, which is useful for low-stakes gamblers who simply want to gamble for fun. Withdrawals can be made via Skrill, Neteller, Bankwire, EcoPayz and bank transfer. Most withdrawals are completed within 48 hours, although bank transfers can take 3-5 working days.
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Foods to Eat in Winter : The winter is here and during winter its important to stay healthy or else winter can affect us in many ways. At the time of winter body changes like metabolism, energy levels and more. Due to all these changes the body may get affected, so its important to be healthy. Here are some foods to try in these winter to stay healthy and unaffected.
The pomegranates has made to our list at top of Foods to eat in winter and stay healthy. Pomegranates are the great source of antioxidants as compare to other juices. Thus having a cup daily will help you in reducing the bad cholesterol i.e. LDL Cholestrol. Pomegranates are also good for keeping the heart healthy.
Potatoes can be great for winter as it contains many beneficial nutrients. They also contains starch that make them not a good option but having the Vitamins like C and B in sufficient quantity makes them good for health. Thus it also helps in enhancing the immunity. Potatoes are also rich source of folate and will help both children and women.
Another immunity booster is here, The Ginger. Consuming the fresh ginger will result in boosting the immunity level to an another level.
You very well know that Citrus fruits and vegetables are the great source of Vitamin C and that's why its good during winter to eat these foods. Citrus foods contains flavonoids, which helps in lowering the level of Bad cholesterol, that is LDL Cholestrol.
The chard, collards and kale are one of the importants dark green leafy vegetable to eat during winter. These vegetables will keep away cold from and will help in keeping you warm. Thus having a rich sources of Vitamins A, C and K will surely help in winter.
The winter squash have many varieties like acorn, delicata, butternut and spaghetti squask make it great for eating in winter. Winter squash are high in calories but are also the rich sources of vitamin A & vitamin C and also have the vitamins like B6, K along with potassium and folate.


A Standards Setting Committee of 18 independent experts has been appointed by the IPMSC to draft and consult on the new International Property Measurement Standards.
The committee is represented by 18 property experts from 11 different countries and 5 different continents. Between them, the Standards Setting Committee has experience of property measurement methodologies in almost 50 countries.
The committee has been hard at work, sharing information and drawing on the expertise of its members during recent meetings to gain a comprehensive understanding of the challenges associated with inconsistent measurement practices. Our programme of work over the coming months is an ambitious one, but we are in no doubt that the standards being developed will go a long way to improving transparency in real estate markets around the world.


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If you have a family member who is a U.S. citizen or lawful permanent resident, you may be eligible to apply for a green card. Whether you are inside or outside the U.S., we can help you through the process of becoming a lawful permanent resident.
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There are several legal remedies available to those in removal proceedings in immigration court. Eligibility depends upon each individual's specific immigration, criminal, and family history, among other factors.
We have experience in the following areas:
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Victims of Crime & Trafficking
Congress created temporary visas and permanent residency options for qualifying victims of crimes and trafficking in the United States in keeping with the humanitarian interests of the United States. Ana Lisa Peña has over ten years of experience working with men, women and children who were victims of crimes in the U.S. or abroad.
If you are a lawful permanent resident or your parents or grandparents are U.S. citizens, you may be eligible to naturalize or you may already be a U.S. citizen. We are happy to evaluate your case in detail with you; becoming a U.S. citizen has many benefits and advantages that lawful permanent residents do not have.
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Temporary, two and three-year programs are available to those who came to the U.S. when they were young children, or for parents of U.S. citizens and legal permanent residents. "Deferred Action" has existed for decades, and offers protection from deportation and other important benefits, such as work authorization. We can help you understand whether you are eligible and help ensure that your application is complete.
APPLICATIONS FOR ASYLUM, WITHHOLDING FROM REMOVAL, AND PROTECTION UNDER THE CONVENTION AGAINST TORTURE.
Asylum is a humanitarian remedy available to those who have been persecuted in the past or those who have a well-founded fear of persecution upon return to their home country based on being a member of a protected group, among other factors. Filing for asylum either affirmatively or defensively (outside of Immigration Court or after immigration proceedings have commenced) is a trying and detailed process. The attorneys at this firm have experience filing and winning asylum cases for clients from Mexico, Honduras, El Salvador, Guatemala, China, Saudi Arabia, Ukraine, and many other countries.
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Those entering the United States to seek refuge from persecution are subject to a credible fear interview with an asylum officer. We help prepare recent entrants for the interview and appear at the interview at the client's request.
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Those entering the United States to seek refuge from persecution, who have prior final orders of removal, are subject to a reasonable fear interview with an asylum officer. We help prepare recent entrants for the interview and appear at the interview at the client's request.
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If Immigration and Customs Enforcement has issued a high bond or has denied bond, we can provide representation in requesting a reconsideration of that decision.
LAWFUL PERMANENT RESIDENT STATUS
Available through family or employment visas, or to special immigrant categories.
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Available to those who have deferred action. Advance Parole allows for brief travel abroad with a showing of good cause.
Peña & Quintana also represents employers and employees in the the following categories of employment-based visas, as well as others:
TN Non-immigrant visas were created by NAFTA (the North American Free Trade Agreement) and are available to citizens of Mexico and Canada with education or experience in certain skilled professions.
Available to highly-skilled professionals, H-1B visas can lead eligibility for lawful permanent resident status and include derivative family members. H-1Bs are subject to a cap of 65,000 visas per year and are filed to coincide with the beginning the new fiscal year.
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H-2As are available for temporary agricultural workers. Employers seeking agricultural workers on a seasonal basis may apply for visas under this program.
H-2Bs are available for temporary non-agricultural workers. Employers seeking workers in non-agricultural areas of the economy in which there is a seasonal or temporary increase in business may seek to add workers through this program.
The E-2 Treaty Investor visa is available to entrepreneurs who are prepared to invest a substantial sum in a new business in the United States and who have a strong business plan which demonstrates the viability of the proposed business. The E-2 allows for derivative family members to enter the U.S. with the principal applicant.
Copyright © 2016 Peña & Quintana, PLLC. All rights reserved.


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Youth and experience blend in USA's successful title defence
8 July 2019 – Perfect balance of talent wins World Cup for USA.
Megan Rapinoe says this is her best World Cup yet.
Julie Ertz moved by emotional journey.
By Erin Fish with USA
After the match and after the celebrations, Julie Ertz was overcome by emotion. She fell to her knees, realising exactly what she and her team-mates had just accomplished and everything they had to go through to get to that point.
The USA are back-to-back FIFA Women's World Cup™ champions, an incredible feat that few will ever accomplish in their lifetime.
But this squad was not the same as it was in 2015. In fact, only 12 of the players on this current squad were on the 2015 championship team.
USA defeated the Netherlands 2-0 on Sunday (7 July) after a hard-fought battle between the two squads. The Americans eventually came out on top, propelled first by captain Megan Rapinoe's buried penalty kick in the 61st minute. Rapinoe, 34, became the oldest goalscorer in the history of the Women's World Cup final.
Rose Lavelle, the USA's 24-year-old midfield dynamo, added a remarkable solo strike in the 69th minute to give her side a secure lead. Contributions to the scoresheet from a budding USA star and an established one summed up the dynamic of this squad perfectly.
Rapinoe said winning this World Cup is different and better for her as a more senior player and as one of the captains.
"The cherry on top was little Rose [Lavelle] scoring today. It's been a fantastic tournament for her," Rapinoe said. "But everything, like [Ali Krieger] getting in and playing in a World Cup final after not being with the squad for two years, Christen Press's celebration, Rose's goal, Alyssa [Naeher's] penalty save. It's amazing, I don't even have words."
From day one the US have talked about the dynamic of this group and how it was great to have a mix of veteran players as well as youth. There is experience and there is also a sense of freshness that the new players bring, all while maintaining what they call the "USWNT culture" that has been passed down from generation to generation.
This culture is a winning mentality learned from the minute you step into youth camps. It is gritty and competitive and about pushing each other to be the best. The minute this team touched down in France, they were all business. They were putting a fourth star on that crest, or the tournament would not be a success.
In between the two World Cups it was not always smooth sailing for this squad. In 2016, the team was knocked out of the Rio Olympics at the quarter-final stage by Sweden, and that called for a change to take place. Coach Jill Ellis began to tactically restructure the team, and the squad had to find themselves again.
Three years later, they have done it. Ertz sat there on her knees in the centre of the stadium in Lyon and just took it all in.
(source: FIFA.com)


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