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Centre for Integrated Preclinical Drug Development
The Centre for Integrated Preclinical Drug Development (CIPDD) in the Faculty of Medicine has state-of-the-art physical infrastructure located in NATA-accredited facilities on the St Lucia Campus of The University of Queensland (UQ).
Our research at the CIPDD is aimed at bringing innovation into the methods used for translational research, particularly in discovery-translation in the pain field including use of these models to screen new molecules for analgesic activity and to probe the pathobiology of individual human pain conditions.
Our research is funded by grants from competitive funding agencies such as the NHMRC, Therapeutic Innovation Australia/National Collaborative Research Infrastructure Strategy (NCRIS), and various not-for-profit organisations, usually in collaboration with Industry and academic partners. We also undertake contract-funded research in collaboration with biotechnology and Pharma companies globally.
Over the past two decades at the CIPDD, we have developed a portfolio of 16 rodent pain models that mimic individual human pain conditions. Research using these models is undertaken in a NATA (National association of Testing Authorities)-accredited facility that is unique in Australia and rare internationally. Our research using these models is two-fold, namely:
Investigation of between-model differences in pathophysiology to gain insight on differences in the pathobiology of individual human pain conditions
Efficacy profiling of new molecules from drug discovery programs that have the potential to be progressed into development as novel analgesics for human use
Members of our highly skilled CIPDD team advise/co-advise PhD, M Biotech, Honours and summer vacation research students working on projects within the afore-mentioned research themes.
Therapeutical Innovation Australia (TIA) - Small Molecule Drug Discovery
The CIPDD (Centre for Integrated Preclinical Drug Development) is part of an integrated capability network of National Research Infrastructure that supports Small Molecule Drug Discovery. These facilities provide expertise and infrastructure to support leading-edge research and boost innovation across Australia. For more information, visit Therapeutic Innovation Australia's Pipeline Navigator for an interactive map of translational capabilities accessible to researchers.
Studies conducted with CIPDD are eligible for consideration for funding by the Therapeutical Innovation Australia Pipeline Accelerator Voucher Scheme. In brief, this scheme aims to support early-stage therapeutic development projects by providing up to $50,000 with 50% matching funding (co-investment) by the applicant. View more details.
Our specialised expertise lies in the field of pain. We focus on discovery- translation and new drug development and have:
A portfolio of sophisticated/refined rodent pain models that mimic individual human pain conditions
Studies are conducted in a purpose-built, NATA-accredited facility; unique in Australia and rare internationally
Aim: Improve preclinical to clinical research translation in the chronic pain field
capabilities to establish other efficacy models in rodents upon request
Our methods for efficacy testing include:
Pain behavioural read-outs (blinded assessments): mechanical allodynia, mechanical & thermal hyperalgesia, burrowing, gait analysis (CatWalk™ XT system)
ex vivo: IHC, molecular biological methods, etc.
We use multiple dosing routes
I.c.v., i.t., i.v. injection or infusion (via Culex machine), i.p., s.c., oral by gavage, i.pl., i.d.
We currently have 16 established pain models for a range of diseases.
Chemotherapy-induced peripheral neuropathy (cisplatin)
2 x antiretriviral drug induced toxic neuropathy (d4T, ddC)
Sciatica – Chronic constriction injury of the sciatic nerve
Relapsing-remitting experimental autoimmune encephalomyelitis (RR-EAE)-mouse model of multiple sclerosis-induced central neuropathic pain
Streptozotocin (STZ)-induced rat model of painful diabetic neuropathy (PDN)
ZDF genetic type 2 diabetic rat model of PDN
Capsaicin-induced hindpaw sensitivity
Mixed neuropathic / inflammatory pain
2x cancer-induced bone pain: breast and prostate
Inflammatory pain
Chronic low back pain
Monoiodoacetate (MIA)-induced rat model of knee osteoarthritis
i.pl. Freund's Complete Adjuvant (FCA)-induced unilateral inflammatory pain in the rat hindpaw
Nociceptive pain
Post-surgical pain (Brennan model)
Acute pain (tail flick)
Acute pain (hot plate)
i.pl. formalin
Other models include:
Triple Negative Breast Cancer Xenograft Model
Other methods include assessment of:
Respiratory depression via plethysmography in awake, freely moving rats
Constipation in rats
GI motility in rats
Castor oil induced diarrhoea in rats
Emeritus Professor Maree Smith
Dr Andy Kuo
Senior Research Officer & Centre Manager, CIPDD
Dr Mohammad Zafar Imam
Research Officer
Dr Rui Li
Senior Research Assistant
Ms Angela Raboczyj
Dr Ana Elisa Bohmer Morschbacher
Pain pharmacology and the pharmacological management of pain
Smith, Maree T. and Muralidharan, Arjun (2014). Pain pharmacology and the pharmacological management of pain. Pain: a textbook for health professionals. (pp. 159-180) edited by Hubert van Griensven, Jenny Strong and Anita M. Unruh. London, United Kingdom: Elsevier.
Antidepressant analgesics
Watson, C. Peter N., Gilron, Ian, Pollock, Bruce G., Lipman, Arthur G. and Smith, Maree T. (2013). Antidepressant analgesics. Wall and Melzack's textbook of pain. (pp. 465-496) edited by Stephen B. McMahon, Martin Koltzenberg, Irene Tracey and Dennis C. Turk. Philadelphia, United States: Elsevier Saunders.
Pharmacogenetics of pain
Smith, Maree T. and Muralidharan, Arjun (2013). Pharmacogenetics of pain. eLS: Citable Reviews in the Life Sciences. (pp. 1-12) Chichester, U.K.: John Wiley & Sons. doi: 10.1002/047001590X
Opioid analgesics
Smith, Maree T. and Goh, Wei H. (2011). Opioid analgesics. Pain management: Current issues and opinions. (pp. 287-306) edited by Gabor B. Racz and Carl E. Noe. Rijeka, Croatia: Intech Open Access.
Pain pharmacology and analgesia
Smith, Maree T. and South, Samantha M. (2008). Pain pharmacology and analgesia. Encyclopedia of Life Support Systems. (pp. 1-80) edited by H. Majewski. Oxford, U.K.: EOLSS Publishers.
Neurobiology of Pain: Identification of novel targets for new pain management medications
Smith, M. T. (2003). Neurobiology of Pain: Identification of novel targets for new pain management medications. Molecular Pathomechanisms and New Trends in Drug Research. (pp. 302-318) edited by G. Keri and I. Toth. London & New York: Taylor & Francis.
Clinical pharmacology and adverse effects
Mather, L. E. and Smith, M. T. (1999). Clinical pharmacology and adverse effects. Opioids in pain control: Basic and clinical aspects. (pp. 188-211) edited by Christoph Stein. New Jersey, USA: Cambridge University Press.
Prostate cancer induced bone pain: pathobiology, current treatments and pain responses from recent clinical trials
Smith, A. E., Muralidharan, A. and Smith, M. T. (2022). Prostate cancer induced bone pain: pathobiology, current treatments and pain responses from recent clinical trials. Discover Oncology, 13 (1) 108. doi: 10.1007/s12672-022-00569-z
Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain
Kong, Dehui, Saqer, Alaa A., Carpinelli de Jesus, Matheus, Khan, Nemat, Jones, Alun, Blanchfield, Joanne T., Smith, Maree T. and Williams, Craig M. (2022). Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain. Bioorganic & Medicinal Chemistry, 69 116889, 116889. doi: 10.1016/j.bmc.2022.116889
Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacy
Xu, Weizhi, Kumar, Vinod, Cui, Cedric S., Li, Xaria X., Whittaker, Andrew K., Xu, Zhi Ping, Smith, Maree T., Woodruff, Trent M. and Han, Felicity Y (2022). Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacy. Advanced Therapeutics 2200109, 2200109. doi: 10.1002/adtp.202200109
Nonopioid analgesics discovery and the Valley of Death: EMA401 from concept to clinical trial
Smith, Maree T. (2022). Nonopioid analgesics discovery and the Valley of Death: EMA401 from concept to clinical trial. Pain, Publish Ahead of Print (S1), S15-S28. doi: 10.1097/j.pain.0000000000002675
Gait analysis as a robust pain behavioural endpoint in the chronic phase of the monoiodoacetate-induced knee joint pain in the rat
Han, Felicity Y., Brockman, David A., Nicholson, Janet R., Corradini, Laura and Smith, Maree Therese (2022). Gait analysis as a robust pain behavioural endpoint in the chronic phase of the monoiodoacetate-induced knee joint pain in the rat. Behavioural Pharmacology, 33 (1), 23-31. doi: 10.1097/fbp.0000000000000663
Journey to the market: The evolution of biodegradable drug delivery systems
Zhu, Minze, Whittaker, Andrew K., Han, Felicity Y. and Smith, Maree T. (2022). Journey to the market: The evolution of biodegradable drug delivery systems. Applied Sciences, 12 (2) 935. doi: 10.3390/app12020935
Analgesic opioid ligand discovery based on nonmorphinan scaffolds derived from natural sources
Smith, Maree T., Kong, Dehui, Kuo, Andy, Imam, Mohammad Z. and Williams, Craig M. (2022). Analgesic opioid ligand discovery based on nonmorphinan scaffolds derived from natural sources. Journal of Medicinal Chemistry, 65 (3) acs.jmedchem.0c01915, 1612-1661. doi: 10.1021/acs.jmedchem.0c01915
Sustained-release ketamine-loaded lipid-particulate system: in vivo assessment in mice
Xu, Weizhi, Maqbool, Faheem, Kumar, Vinod, Falconer, James R., Cui, Cedric S., Woodruff, Trent M., Borges, Karin, Whittaker, Andrew K., Smith, Maree T. and Han, Felicity Y. (2021). Sustained-release ketamine-loaded lipid-particulate system: in vivo assessment in mice. Drug Delivery and Translational Research, 12 (10), 2518-2526. doi: 10.1007/s13346-021-01093-3
Pharmacological characterization of the chronic phase of the monoiodoacetate‐induced rat model of osteoarthritis pain in the knee joint
Han, Felicity Y., Brockman, David A., Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2021). Pharmacological characterization of the chronic phase of the monoiodoacetate‐induced rat model of osteoarthritis pain in the knee joint. Clinical and Experimental Pharmacology and Physiology, 48 (11) 1440-1681.13551, 1515-1522. doi: 10.1111/1440-1681.13551
Editorial: verification of animal pain models by reverse translation
Caudle, Robert M., Smith, Maree Therese and Romero-Sandoval, E. Alfonso (2021). Editorial: verification of animal pain models by reverse translation. Frontiers in Pharmacology, 12 778880, 778880. doi: 10.3389/fphar.2021.778880
Optimisation of a microfluidic method for the delivery of a small peptide
Han, Felicity Y., Xu, Weizhi, Kumar, Vinod, Cui, Cedric S., Li, Xaria, Jiang, Xingyu, Woodruff, Trent M., Whittaker, Andrew K. and Smith, Maree T. (2021). Optimisation of a microfluidic method for the delivery of a small peptide. Pharmaceutics, 13 (9) 1505, 1505. doi: 10.3390/pharmaceutics13091505
Assessment of the anti-allodynic and anti-hyperalgesic efficacy of a glycine transporter 2 inhibitor relative to pregabalin, duloxetine and indomethacin in a rat model of cisplatin-induced peripheral neuropathy
Kuo, Andy, Corradini, Laura, Nicholson, Janet R. and Smith, Maree T. (2021). Assessment of the anti-allodynic and anti-hyperalgesic efficacy of a glycine transporter 2 inhibitor relative to pregabalin, duloxetine and indomethacin in a rat model of cisplatin-induced peripheral neuropathy. Biomolecules, 11 (7) 940, 1-17. doi: 10.3390/biom11070940
Sustained release ketamine-loaded porous silicon-PLGA microparticles prepared by an optimized supercritical CO2 process
Xu, Weizhi, Zhao, Zonglan, Falconer, James, Whittaker, Andrew K., Popat, Amirali, Smith, Maree T., Kumeria, Tushar and Han, Felicity Y. (2021). Sustained release ketamine-loaded porous silicon-PLGA microparticles prepared by an optimized supercritical CO2 process. Drug Delivery and Translational Research, 12 (3), 676-694. doi: 10.1007/s13346-021-00991-w
Characterisation of a rat model of mechanical low back pain at an advanced stage using immunohistochemical methods
Park, Thomas S.W., Khan, Nemat, Kuo, Andy, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2021). Characterisation of a rat model of mechanical low back pain at an advanced stage using immunohistochemical methods. Clinical and Experimental Pharmacology and Physiology, 48 (1) 1440-1681.13402, 96-106. doi: 10.1111/1440-1681.13402
Use of microfluidics to fabricate bioerodable lipid hybrid nanoparticles containing hydromorphone or ketamine for the relief of intractable pain
Zhu, Minze, Whittaker, Andrew K., Jiang, Xingyu, Tang, Rupei, Li, Xuanyu, Xu, Weizhi, Fu, Changkui, Smith, Maree T. and Han, Felicity Y. (2020). Use of microfluidics to fabricate bioerodable lipid hybrid nanoparticles containing hydromorphone or ketamine for the relief of intractable pain. Pharmaceutical Research, 37 (10) 211, 1-12. doi: 10.1007/s11095-020-02939-0
Herbicides that target acetohydroxyacid synthase are potent inhibitors of the growth of drug resistant Candida auris
Agnew-Francis, Kylie A., Tang, Yu Cheng, Lin, Xin, Low, Yu Shang, Wun, Shun Jie, Kuo, Andy, Elias, S. M. A. Sayeed Ibn, Lonhienne, Thierry G., Condon, Nicholas, Pimentel, Bruna Natalia Alves da Silva, Vergani, Carlos, Smith, Maree T., Fraser, James A., Williams, Craig M. and Guddat, Luke W (2020). Herbicides that target acetohydroxyacid synthase are potent inhibitors of the growth of drug resistant Candida auris. ACS infectious diseases, 6 (11) acsinfecdis.0c00229, 2901-2912. doi: 10.1021/acsinfecdis.0c00229
Assessment of the anti-allodynic efficacy of a glycine transporter 2 inhibitor relative to pregabalin and duloxetine in a rat model of prostate cancer-induced bone pain
Imam, Mohammad Zafar, Kuo, Andy, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2020). Assessment of the anti-allodynic efficacy of a glycine transporter 2 inhibitor relative to pregabalin and duloxetine in a rat model of prostate cancer-induced bone pain. Pharmacological Reports, 72 (5), 1418-1425. doi: 10.1007/s43440-020-00145-8
Assessment of the anti‐hyperalgesic efficacy of J‐2156, relative to clinically available analgesic/adjuvant agents in a rat model of mild to moderate chronic mechanical low back pain (LBP)
Kuo, Andy, Lourdesamy, Jacintha, Nicholson, Janet R., Corradini, Laura and Maree, Smith T. (2020). Assessment of the anti‐hyperalgesic efficacy of J‐2156, relative to clinically available analgesic/adjuvant agents in a rat model of mild to moderate chronic mechanical low back pain (LBP). Clinical and Experimental Pharmacology and Physiology, 47 (12) 1440-1681.13383, 1912-1922. doi: 10.1111/1440-1681.13383
Comparative studies of glial fibrillary acidic protein and brain‐derived neurotrophic factor expression in two transgenic mouse models of Alzheimer's disease
Edwards, Stephen R., Khan, Nemat, Coulson, Elizabeth J. and Smith, Maree T. (2020). Comparative studies of glial fibrillary acidic protein and brain‐derived neurotrophic factor expression in two transgenic mouse models of Alzheimer's disease. Clinical and Experimental Pharmacology and Physiology, 47 (10) 1440-1681.13363, 1740-1750. doi: 10.1111/1440-1681.13363
Sustained-release ketamine-loaded nanoparticles fabricated by sequential nanoprecipitation
Han, Felicity Y., Liu, Yun, Kumar, Vinod, Xu, Weizhi, Yang, Guangze, Zhao, Chun-Xia, Woodruff, Trent M., Whittaker, Andrew K. and Smith, Maree T. (2020). Sustained-release ketamine-loaded nanoparticles fabricated by sequential nanoprecipitation. International Journal of Pharmaceutics, 581 119291, 119291. doi: 10.1016/j.ijpharm.2020.119291
In vitro profiling of opioid ligands using the cAMP formation inhibition assay and the β-arrestin2 recruitment assay: No two ligands have the same profile
Kuo, Andy, Magiera, Julia, Rethwan, Nursyazwani, Andersson, Åsa, Leen Lam, Ai, Wyse, Bruce, Meutermans, Wim, Lewis, Richard and Smith, Maree (2020). In vitro profiling of opioid ligands using the cAMP formation inhibition assay and the β-arrestin2 recruitment assay: No two ligands have the same profile. European Journal of Pharmacology, 872 172947, 172947. doi: 10.1016/j.ejphar.2020.172947
Intracerebroventricular administration of CYX-6, a potent μ-opioid receptor agonist, a δ- and κ-opioid receptor antagonist and a biased ligand at μ, δ & κ-opioid receptors, evokes antinociception with minimal constipation and respiratory depression in rats in contrast to morphine
Imam, Mohammad Zafar, Kuo, Andy, Ghassabian, Sussan, Cai, Yunxin, Qin, Yajuan, Li, Tingyou and Smith, Maree T. (2020). Intracerebroventricular administration of CYX-6, a potent μ-opioid receptor agonist, a δ- and κ-opioid receptor antagonist and a biased ligand at μ, δ & κ-opioid receptors, evokes antinociception with minimal constipation and respiratory depression in rats in contrast to morphine. European Journal of Pharmacology, 871 172918, 172918. doi: 10.1016/j.ejphar.2020.172918
Countering opioid-induced respiratory depression by non-opioids that are respiratory stimulants
Imam, Mohammad Zafar, Kuo, Andy and Smith, Maree T. (2020). Countering opioid-induced respiratory depression by non-opioids that are respiratory stimulants. F1000Research, 9 91, 91. doi: 10.12688/f1000research.21738.1
Transcriptomic characterisation of the optimised rat model of Walker 256 breast cancer cell-induced bone pain
Shenoy, Priyank A., Kuo, Andy, Leparc, German, Hildebrandt, Tobias, Rust, Werner, Nicholson, Janet R., Corradini, Laura, Vetter, Irina and Smith, Maree T. (2019). Transcriptomic characterisation of the optimised rat model of Walker 256 breast cancer cell-induced bone pain. Clinical and Experimental Pharmacology and Physiology, 46 (12) 1440-1681.13165, 1201-1215. doi: 10.1111/1440-1681.13165
J-2156, a somatostatin receptor type 4 agonist, alleviates mechanical hyperalgesia in a rat model of chronic low back pain
Park, Thomas S.W., Khan, Nemat, Kuo, Andy, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2019). J-2156, a somatostatin receptor type 4 agonist, alleviates mechanical hyperalgesia in a rat model of chronic low back pain. Biomedicine and Pharmacotherapy, 117 109056, 109056. doi: 10.1016/j.biopha.2019.109056
The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement
Houston, Sevan D., Fahrenhorst-Jones, Tyler, Xing, Hui, Chalmers, Benjamin A., Sykes, Melissa L., Stok, Jeanette E., Farfan Soto, Clementina, Burns, Jed M., Bernhardt, Paul V., De Voss, James J., Boyle, Glen M., Smith, Maree T., Tsanaktsidis, John, Savage, G. Paul, Avery, Vicky M. and Williams, Craig M. (2019). The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement. Organic and Biomolecular Chemistry, 17 (28), 6790-6798. doi: 10.1039/c9ob01238a
Study Protocol for a Pilot, Open-Label, Prospective, and Observational Study to Evaluate the Pharmacokinetics of Drugs Administered to Patients during Extracorporeal Circulation; Potential of In Vivo Cytochrome P450 Phenotyping to Optimise Pharmacotherapy
Adiraju, Santosh Kumar Sreevatsav, Shekar, Kiran, Tesar, Peter, Naidoo, Rishendran, Rapchuk, Ivan, Belz, Stephen, Fraser, John F., Smith, Maree T. and Ghassabian, Sussan (2019). Study Protocol for a Pilot, Open-Label, Prospective, and Observational Study to Evaluate the Pharmacokinetics of Drugs Administered to Patients during Extracorporeal Circulation; Potential of In Vivo Cytochrome P450 Phenotyping to Optimise Pharmacotherapy. Methods and Protocols, 2 (2) 38, 38-12. doi: 10.3390/mps2020038
Nitric oxide modulates μ‐opioid receptor function in vitro
Huang, Lillian, Wyse, Bruce D., Williams, Craig M. and Smith, Maree T. (2019). Nitric oxide modulates μ‐opioid receptor function in vitro. Clinical and Experimental Pharmacology and Physiology, 46 (7) 1440-1681.13091, 676-685. doi: 10.1111/1440-1681.13091
Establishment and characterisation of a stavudine (d4T)-induced rat model of antiretroviral toxic neuropathy (ATN) using behavioural and pharmacological methods
Kuo, Andy, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2019). Establishment and characterisation of a stavudine (d4T)-induced rat model of antiretroviral toxic neuropathy (ATN) using behavioural and pharmacological methods. Inflammopharmacology, 27 (2), 387-396. doi: 10.1007/s10787-018-00551-8
Bioerodable ketamine-loaded microparticles fabricated using dissolvable hydrogel template technology
Zhu, Minze, Whittaker, Andrew K., Smith, Maree T. and Han, Felicity Y. (2019). Bioerodable ketamine-loaded microparticles fabricated using dissolvable hydrogel template technology. Journal of Pharmaceutical Sciences, 108 (3), 1220-1226. doi: 10.1016/j.xphs.2018.10.029
Cyclooctatetraene: a bioactive cubane paradigm complement
Xing, Hui, Houston, Sevan D., Chen, Xuejie, Ghassabian, Sussan, Fahrenhorst-Jones, Tyler, Kuo, Andy, Murray, Cody-Ellen P., Conn, Kyna-Anne, Jaeschke, Kara N., Jin, Da-Yun, Pasay, Cielo, Bernhardt, Paul V., Burns, Jed M., Tsanaktsidis, John, Savage, G. Paul, Boyle, Glen M., De Voss, James J., McCarthy, James, Walter, Gimme H., Burne, Thomas H. J., Smith, Maree T., Tie, Jian-Ke and Williams, Craig M. (2019). Cyclooctatetraene: a bioactive cubane paradigm complement. Chemistry: A European Journal, 25 (11), 2729-2734. doi: 10.1002/chem.201806277
Sustained-release hydromorphone microparticles produced by supercritical fluid polymer encapsulation
Han, Felicity Y., Whittaker, Andrew, Howdle, Steven M., Naylor, Andrew, Shabir-Ahmed, Anjumn and Smith, Maree T. (2019). Sustained-release hydromorphone microparticles produced by supercritical fluid polymer encapsulation. Journal of Pharmaceutical Sciences, 108 (2), 811-814. doi: 10.1016/j.xphs.2018.09.021
Formulation of bioerodible ketamine microparticles as an analgesic adjuvant treatment produced by supercritical fluid polymer encapsulation
Han, Felicity, Whittaker, Andrew, Howdle, Steven, Naylor, Andrew, Shabir-Ahmed, Anjumn, Zhang, Cheng and Smith, Maree (2018). Formulation of bioerodible ketamine microparticles as an analgesic adjuvant treatment produced by supercritical fluid polymer encapsulation. Pharmaceutics, 10 (4) 264, 264. doi: 10.3390/pharmaceutics10040264
An improved LC-MS/MS method for simultaneous evaluation of CYP2C9, CYP2C19, CYP2D6 and CYP3A4 activity
Sreevatsav Adiraju, Santosh Kumar, Shekar, Kiran, Fraser, John F., Smith, Maree T. and Ghassabian, Sussan (2018). An improved LC-MS/MS method for simultaneous evaluation of CYP2C9, CYP2C19, CYP2D6 and CYP3A4 activity. Bioanalysis, 10 (19), 1577-1590. doi: 10.4155/bio-2018-0102
Corrigendum to: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere (Angewandte Chemie International Edition, (2016), 55, 11, (3580-3585), 10.1002/anie.201510675)
Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2018). Corrigendum to: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere (Angewandte Chemie International Edition, (2016), 55, 11, (3580-3585), 10.1002/anie.201510675). Angewandte Chemie - International Edition, 57 (28), 8359-8359. doi: 10.1002/anie.201711161
Effects of long-term opioid analgesics on cognitive performance and plasma cytokine concentrations in patients with chronic low back pain : a cross-sectional pilot study
Richards, Georgia C., Lluka, Lesley J., Smith, Maree T., Haslam, Catherine, Moore, Brendan, O'Callaghan, James and Strong, Jenny (2018). Effects of long-term opioid analgesics on cognitive performance and plasma cytokine concentrations in patients with chronic low back pain : a cross-sectional pilot study. PAIN Reports, 3 (4) e669, e669. doi: 10.1097/pr9.0000000000000669
In vivo profiling of four centrally administered opioids for antinociception, constipation and respiratory depression: between colony differences in Sprague Dawley rats
Kuo, Andy and Smith, Maree T. (2018). In vivo profiling of four centrally administered opioids for antinociception, constipation and respiratory depression: between colony differences in Sprague Dawley rats. Clinical and Experimental Pharmacology & Physiology, 45 (10), 1056-1066. doi: 10.1111/1440-1681.12972
Comparative analgesic efficacy of pregabalin administered according to either a prevention protocol or an intervention protocol in rats with cisplatin-induced peripheral neuropathy
Han, Felicity Y., Kuo, Andy, Nicholson, Janet R., Corradinni, Laura and Smith, Maree T. (2018). Comparative analgesic efficacy of pregabalin administered according to either a prevention protocol or an intervention protocol in rats with cisplatin-induced peripheral neuropathy. Clinical and Experimental Pharmacology and Physiology, 45 (10), 1067-1075. doi: 10.1111/1440-1681.12971
Chronic low back pain: a mini-review on pharmacological management and pathophysiological insights from clinical and pre-clinical data
Park, Thomas S. W., Kuo, Andy and Smith, Maree T. (2018). Chronic low back pain: a mini-review on pharmacological management and pathophysiological insights from clinical and pre-clinical data. Inflammopharmacology, 26 (4), 1-18. doi: 10.1007/s10787-018-0493-x
The somatostatin receptor-4 agonist J-2156 alleviates mechanical hypersensitivity in a rat model of breast cancer induced bone pain
Shenoy, Priyank A., Kuo, Andy, Khan, Nemat, Gorham, Louise, Nicholson, Janet, Corradini, Laura, Vetter, Irina and Smith, Maree T. (2018). The somatostatin receptor-4 agonist J-2156 alleviates mechanical hypersensitivity in a rat model of breast cancer induced bone pain. Frontiers in Pharmacology, 9 (MAY) 495, 495. doi: 10.3389/fphar.2018.00495
An improved liquid chromatography tandem mass spectrometry (LC-MS/MS) method for quantification of dexmedetomidine concentrations in samples of human plasma
Moosavi, Seyed Mojtaba, Shekar, Kiran, Fraser, John F., Smith, Maree T. and Ghassabian, Sussan (2018). An improved liquid chromatography tandem mass spectrometry (LC-MS/MS) method for quantification of dexmedetomidine concentrations in samples of human plasma. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 1073, 118-122. doi: 10.1016/j.jchromb.2017.12.006
Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain
Lee, Jia Yu Peppermint, Saez, Natalie J., Cristofori-Armstrong, Ben, Anangi, Raveendra, King, Glenn F., Smith, Maree T. and Rash, Lachlan D. (2018). Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain. British Journal of Pharmacology, 175 (12), 2204-2218. doi: 10.1111/bph.14089
Synthesis and Biological Evaluation of Fentanyl Analogues Modified at Phenyl Groups with Alkyls
Qin, Yajuan, Ni, Luofan, Shi, Jiawei, Zhu, Zhiying, Shi, Saijian, Lam, Ai-Leen, Magiera, Julia, Sekar, Sunderajhan, Kuo, Andy, Smith, Maree T. and Li, Tingyou (2018). Synthesis and Biological Evaluation of Fentanyl Analogues Modified at Phenyl Groups with Alkyls. ACS Chemical Neuroscience, 10 (1) acschemneuro.8b00363, 201-208. doi: 10.1021/acschemneuro.8b00363
Progress in understanding mechanisms of opioid-induced gastrointestinal adverse effects and respiratory depression
Imam, Mohammad Zafar, Kuo, Andy, Ghassabian, Sussan and Smith, Maree T. (2017). Progress in understanding mechanisms of opioid-induced gastrointestinal adverse effects and respiratory depression. Neuropharmacology, 131, 238-255. doi: 10.1016/j.neuropharm.2017.12.032
Effect of cardiopulmonary bypass on cytochrome P450 enzyme activity: implications for pharmacotherapy
Adiraju, Santosh Kumar Sreevatsav, Shekar, Kiran, Fraser, John F, Smith, Maree T and Ghassabian, Sussan (2017). Effect of cardiopulmonary bypass on cytochrome P450 enzyme activity: implications for pharmacotherapy. Drug metabolism reviews, 50 (2), 1-16. doi: 10.1080/03602532.2017.1417423
Morphine hyposensitivity in STZ-diabetic rats: reversal by dietary L-arginine treatment
Lotfipour, Shahrdad and Smith, Maree T. (2017). Morphine hyposensitivity in STZ-diabetic rats: reversal by dietary L-arginine treatment. Clinical and Experimental Pharmacology & Physiology, 45 (1), 42-49. doi: 10.1111/1440-1681.12855
Attenuation of the Infiltration of Angiotensin II Expressing CD3+ T-Cells and the Modulation of Nerve Growth Factor in Lumbar Dorsal Root Ganglia – A Possible Mechanism Underpinning Analgesia Produced by EMA300, An Angiotensin II Type 2 (AT2) Receptor Antagonist
Nemat Khan, Arjun Muralidharan and Maree T. Smith (2017)
Pharmacological inhibition of the NLRP3 inflammasome as a potential target for multiple sclerosis induced central neuropathic pain
Nemat Khan1, Andy Kuo1, David A. Brockman, Matthew A. Cooper, Maree T. Smith (2017)
Lotfipour, Shahrdad and Smith, Maree T. (2017)
Establishment and Characterization of a Novel Rat Model of Mechanical Low Back Pain Using Behavioral, Pharmacologic and Histologic Methods
Arjun Muralidharan1†, Thomas S. W. Park1†, John T. Mackie2, Luiz G. S. Gimenez1, Andy Kuo1, Janet R. Nicholson3, Laura Corradini3 and Maree T. Smith* (2017).
Optimization and In Vivo Profiling of a Refined Rat Model of Walker 256 Breast Cancer Cell-Induced Bone Pain Using Behavioral, Radiological, Histological, Immunohistochemical and Pharmacological Methods
Priyank Shenoy1,2, Andy Kuo1, Irina Vetter3,4 and Maree T. Smith* (2017)
High-throughput assay for quantification of the plasma concentrations of thiopental using automated solid phase extraction (SPE) directly coupled to LC–MS/MS instrumentation
Seyed Mojtaba Moosavi, Kiran Shekar, John Fraser, Maree T. Smith, Sussan Ghassabian (2016). High-throughput assay for quantification of the plasma concentrations of thiopental using automated solid phase extraction (SPE) directly coupled to LC–MS/MS instrumentation. Journal of Chromatography B, http://dx.doi.org/10.1016/j.jchromb.2016.10.038
The Walker 256 breast cancer cell-induced bone pain model in rats
Shenoy, Priyank A., Kuo, Andy, Vetter, Irina and Smith, Maree T. (2016) The Walker 256 breast cancer cell-induced bone pain model in rats. Frontiers in Pharmacology, 7 AUG: . doi:10.3389/fphar.2016.00286
Bioerodable PLGA-Based Microparticles for Producing Sustained-Release Drug Formulations and Strategies for Improving Drug Loading
Han FY, Thurecht KJ, Whittaker AK and Smith MT (2016). Bioerodable PLGA-Based Microparticles for Producing Sustained-Release Drug Formulations and Strategies for Improving Drug Loading. Front. Pharmacol 7:185. doi: 10.3389/fphar.2016.00185
Comparison of burrowing and stimuli-evoked pain behaviors as end-points in rat models of inflammatory pain and peripheral neuropathic pain
Muralidharan, Arjun, Kuo, Andy, Jacob, Meera, Lourdesamy, Jacintha S., Melo Sores Pinho De Carvalho, Lara, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2016) Comparison of burrowing and stimuli-evoked pain behaviors as end-points in rat models of inflammatory pain and peripheral neuropathic pain. Frontiers in Behavioral Neuroscience, 10 88: . doi:10.3389/fnbeh.2016.00088
In Vitro Metabolic Stability and in Vivo Biodistribution of 3‑Methyl-4- furoxancarbaldehyde Using PET Imaging in Rats
Pippi, Adam B., Mohd Arshad, Zaira Hidayah, Vol, Ronald J., Nye, Jonathon A., Ghassabian, Sussan, Williams, Craig M., Mancini, Alessandra, Liotta, Dennis C., Smith, Maree T. and Goodman, Mark M. (2016) In Vitro Metabolic Stability and in Vivo Biodistribution of 3‑Methyl-4- furoxancarbaldehyde Using PET Imaging in Rats. ACS Medicinal Chemistry Letters, . doi:10.1021/acsmedchemlett.5b00410
Evaluation of a high-throughput peptide reactivity format assay for assessment of the skin sensitization potential of chemicals
Wong, Chin Lin, Lam, Ai Leen, Smith, Maree T. and Ghassabian, Sussan (2016) Evaluation of a high-throughput peptide reactivity format assay for assessment of the skin sensitization potential of chemicals. Frontiers in Pharmacology, 7 MAR: . doi:10.3389/fphar.2016.00053
Validating Eaton's hypothesis: cubane as a benzene bioisostere
Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2016) Validating Eaton's hypothesis: cubane as a benzene bioisostere. Angewandte Chemie (International Edition), 55 11: 3580-3585. doi:10.1002/anie.201510675
Selective small molecule angiotensin II type 2 (AT2) receptor antagonists for neuropathic pain: preclinical and clinical studies
Smith, Maree T., Anand, Praveen and Rice, Andrew S. C. (2016) Selective small molecule angiotensin II type 2 (AT2) receptor antagonists for neuropathic pain: preclinical and clinical studies. Pain, 157 Supplement 1: S33-S41. doi:10.1097/j.pain.0000000000000369
Why different pain-killers are only effective for certain types of pain
Smith, Maree (2015) Why different pain-killers are only effective for certain types of pain. The Conversation, .
A novel fully validated LC-MS/MS method for quantification of pyridoxal-5'-phosphate concentrations in samples of human whole blood
Ghassabian, Sussan, Griffiths, Lyn and Smith, Maree T (2015) A novel fully validated LC-MS/MS method for quantification of pyridoxal-5'-phosphate concentrations in samples of human whole blood.Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1000 77-83. doi:10.1016/j.jchromb.2015.07.019
Novel polymeric bioerodable microparticles for prolonged-release intrathecal delivery of analgesic agents for relief of intractable cancer-related pain
Han, Felicity Y., Thurecht, Kristofer J., Lam, Ai-Leen, Whittaker, Andrew K. and Smith, Maree T. (2015) Novel polymeric bioerodable microparticles for prolonged-release intrathecal delivery of analgesic agents for relief of intractable cancer-related pain. Journal of Pharmaceutical Sciences, 1047: 2334-2344. doi:10.1002/jps.24497
Topical application of a novel oxycodone gel formulation (tocopheryl phosphate mixture, TPM) in a rat model of peripheral inflammatory pain produces localized pain relief without significant systemic exposure
Smith, Maree T., Wyse, Bruce D., Edwards, Stephen R., El-Taminy, Mahmoud, Gaetano, Giacinto and Gavin, Paul (2015) Topical application of a novel oxycodone gel formulation (tocopheryl phosphate mixture, TPM) in a rat model of peripheral inflammatory pain produces localized pain relief without significant systemic exposure. Journal of Pharmaceutical Sciences, 104 7: 2388-2396. doi:10.1002/jps.24502
The Furoxan Nitric Oxide Donor, PRG150, Evokes Dose-Dependent Analgesia in a Rat Model of Painful Diabetic Neuropathy (PDN)
Huang, Lillian Y., Tsui, Debbie Y., Williams, Craig M., Wyse, Bruce D. and Smith, Maree T. (2015) The Furoxan Nitric Oxide Donor, PRG150, Evokes Dose-Dependent Analgesia in a Rat Model of Painful Diabetic Neuropathy (PDN). Clinical and Experimental Pharmacology and Physiology, 42 9: 921-929. doi:10.1111/1440-1681.12442
In vivo High Angular Resolution Diffusion-Weighted Imaging of Mouse Brain at 16.4 Tesla
Alomair, Othman I, Brereton, Ian M, Smith, Maree T, Galloway, Graham J and Kurniawan, Nyoman D (2015) In vivo High Angular Resolution Diffusion-Weighted Imaging of Mouse Brain at 16.4 Tesla. Plos One, 10 6: . doi:10.1371/journal.pone.0130133
Neurotrophins and neuropathic pain: role in pathobiology
Khan, Nemat and Smith, Maree T. (2015) Neurotrophins and neuropathic pain: role in pathobiology.Molecules, 20 6: 10657-10688. doi:10.3390/molecules200610657
Antiallodynic effects of alpha lipoic acid in an optimized RR-EAE mouse model of MS-neuropathic pain are accompanied by attenuation of upregulated BDNF-TrkB-ERK signalling in the dorsal horn of the spinal cord
Khan, Nemat, Gordon, Richard, Woodruff, Trent M. and Smith, Maree T. (2015) Antiallodynic effects of alpha lipoic acid in an optimized RR-EAE mouse model of MS-neuropathic pain are accompanied by attenuation of upregulated BDNF-TrkB-ERK signalling in the dorsal horn of the spinal cord.Pharmacology Research and Perspectives, 3 3: 1-16. doi:10.1002/prp2.137
In vitro methods for hazard assessment of industrial chemical - opportunities and challenges
Wong, Chin Lin, Ghassabian, Sussan, Smith, Maree T. and Lam, Ai-Leen (2015) In vitro methods for hazard assessment of industrial chemical - opportunities and challenges. Frontiers in Pharmacology, 694: 1-13. doi:10.3389/fphar.2015.00094
Angiotensin II Type 2-Receptor: New Clinically Validated Target in the Treatment of Neuropathic Pain
Rice, A. S. C. and Smith, M. T. (2015) Angiotensin II Type 2-Receptor: New Clinically Validated Target in the Treatment of Neuropathic Pain. Clinical Pharmacology and Therapeutics, 97 2: 128-130. doi:10.1002/cpt.29
Fully validated LC–MS/MS method for quantification of homocysteine concentrations in samples of human serum: a new approach
Ghassabian, Sussan, Rethwan, Nur Syazwani Ahmad, Griffiths, Lyn and Smith, Maree T. (2014) Fully validated LC–MS/MS method for quantification of homocysteine concentrations in samples of human serum: a new approach. Journal of Chromatography B, 972 14-21. doi:10.1016/j.jchromb.2014.09.032
Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods
Khan, Nemat, Woodruff, Trent M. and Smith, Maree T. (2014) Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. Pharmacology Biochemistry and Behavior, 126 13-27. doi:10.1016/j.pbb.2014.09.003
Optimization and pharmacological characterization of a refined cisplatin-induced rat model of peripheral neuropathic pain
Han, Felicity Yaqin, Wyse, Bruce D. and Smith, Maree T. (2014) Optimization and pharmacological characterization of a refined cisplatin-induced rat model of peripheral neuropathic pain. Behavioural Pharmacology, 25 8: 732-740. doi:10.1097/FBP.0000000000000090
Targeting angiotensin II type 2 receptor pathways to treat neuropathic pain and inflammatory pain
Smith, Maree T. and Muralidharan, Arjun (2014) Targeting angiotensin II type 2 receptor pathways to treat neuropathic pain and inflammatory pain. Expert Opinion On Therapeutic Targets, 19 1: 25-35. doi:10.1517/14728222.2014.957673
Comparative studies using the Morris water maze to assess spatial memory deficits in two transgenic mouse models Of Alzheimer's disease
Edwards, Stephen R., Hamlin, Adam S., Marks, Nicola, Coulson, Elizabeth J. and Smith, Maree T. (2014) Comparative studies using the Morris water maze to assess spatial memory deficits in two transgenic mouse models Of Alzheimer's disease. Clinical and Experimental Pharmacology and Physiology, 41 10: 798-806. doi:10.1111/1440-1681.12277
Theoretical and practical applications of the intracerebroventricular route for CSF sampling and drug administration in CNS drug discovery research: a mini review
Kuo, Andy and Smith, Maree T. (2014) Theoretical and practical applications of the intracerebroventricular route for CSF sampling and drug administration in CNS drug discovery research: a mini review. Journal of Neuroscience Methods, 233 166-171. doi:10.1016/j.jneumeth.2014.06.006
Analgesic efficacy of small-molecule angiotensin II type 2 receptor antagonists in a rat model of antiretroviral toxic polyneuropathy
Smith, Maree T., Lau, Tanya, Wallace, Victoria C. J., Wyse, Bruce D. and Rice, Andrew S. C. (2014) Analgesic efficacy of small-molecule angiotensin II type 2 receptor antagonists in a rat model of antiretroviral toxic polyneuropathy. Behavioural Pharmacology, 25 2: 137-146. doi:10.1097/FBP.0000000000000025
Endomorphin analogues with mixed mu-opioid (MOP) receptor agonism/delta-opioid (DOP) receptor antagonism and lacking beta-arrestin2 recruitment activity
Cai, Jun, Song, Bowen, Cai, Yunxin, Ma, Yu, Lam, Ai-leen, Magiera, Julia, Sekar, Sunder, Wyse, Bruce D., Ambo, Akihiro, Sasaki, Yusuke, Lazarus, Lawrence H., Smith, Maree T. and Li, Tingyou (2014) Endomorphin analogues with mixed mu-opioid (MOP) receptor agonism/delta-opioid (DOP) receptor antagonism and lacking beta-arrestin2 recruitment activity. Biorganic and Medicinal Chemistry, 22 7: 2208-2219. doi:10.1016/j.bmc.2014.02.015
In vivo profiling of seven common opioids for antinociception, constipation and respiratory depression: no two opioids have the same profile
Kuo, A., Wyse, B. D., Meutermans, W. and Smith, M. T. (2014) In vivo profiling of seven common opioids for antinociception, constipation and respiratory depression: no two opioids have the same profile. British Journal of Pharmacology, Accepted Article 1-48. doi:10.1111/bph.12696
Analgesic efficacy and mode of action of a selective small molecule angiotensin II type 2 receptor antagonist in a rat model of prostate cancer-induced bone pain
Muralidharan, Arjun, Wyse, Bruce D. and Smith, Maree T. (2014) Analgesic efficacy and mode of action of a selective small molecule angiotensin II type 2 receptor antagonist in a rat model of prostate cancer-induced bone pain. Pain Medicine, 15 1: 93-110. doi:10.1111/pme.12258
Current developments in MRI for assessing rodent models of multiple sclerosis
Alomair, Othman I., Smith, Maree T., Brereton, Ian M., Galloway, Graham J. and Kurniawan, Nyoman D. (2014) Current developments in MRI for assessing rodent models of multiple sclerosis. Future Neurology, 9 4: 487-511. doi:10.2217/FNL.14.33
Pathobiology of cancer chemotherapy-induced peripheral neuropathy (CIPN)
Han, Yaqin and Smith, Maree T. (2013) Pathobiology of cancer chemotherapy-induced peripheral neuropathy (CIPN). Frontiers in Pharmacology, 4 1-16. doi:10.3389/fphar.2013.00156
Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models
Khan, Nemat and Smith, Maree T. (2013) Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models. Inflammopharmacology, 22 1: 1-22. doi:10.1007/s10787-013-0195-3
Comment On "protective Arms of the Renin-Angiotensin System in Neurological Disease"
Smith, Maree T. and Muralidharan, Arjun (2013) Comment On "protective Arms of the Renin-Angiotensin System in Neurological Disease". Clinical and Experimental Pharmacology and Physiology,40 11: 838-838. doi:10.1111/1440-1681.12169
Pathobiology and management of prostate cancer-induced bone pain: recent insights and future treatments
Muralidharan, Arjun and Smith, Maree T. (2013) Pathobiology and management of prostate cancer-induced bone pain: recent insights and future treatments. Inflammopharmacology, 21 5: 339-363. doi:10.1007/s10787-013-0183-7
A small molecule angiotensin II type 2 receptor (AT2R) antagonist produces analgesia in a rat model of neuropathic pain by inhibition of p38 Mitogen-Activated Protein Kinase (MAPK) and p44/p42 MAPK activation in the dorsal root ganglia
Smith, Maree T., Woodruff, Trent M., Wyse, Bruce D., Muralidharan, Arjun and Walther, Thomas (2013) A small molecule angiotensin II type 2 receptor (AT2R) antagonist produces analgesia in a rat model of neuropathic pain by inhibition of p38 Mitogen-Activated Protein Kinase (MAPK) and p44/p42 MAPK activation in the dorsal root ganglia. Pain Medicine, 14 10: 1557-1568. doi:10.1111/pme.12157
Small molecule angiotensin II type 2 receptor (AT2R) antagonists as novel analgesics for neuropathic pain: comparative pharmacokinetics, radioligand binding, and efficacy in rats
Smith, Maree T., Wyse, Bruce D. and Edwards, Stephen R. (2013) Small molecule angiotensin II type 2 receptor (AT2R) antagonists as novel analgesics for neuropathic pain: comparative pharmacokinetics, radioligand binding, and efficacy in rats. Pain Medicine, 14 5: 692-705. doi:10.1111/pme.12063
Peripherally acting novel lipo-endomorphin-1 peptides in neuropathic pain without producing constipation
Varamini, Pegah, Goh, Wei Huang, Mansfeld, Friederike M., Blanchfield, Joanne T., Wyse, Bruce D., Smith, Maree T. and Toth, Istvan (2013) Peripherally acting novel lipo-endomorphin-1 peptides in neuropathic pain without producing constipation. Bioorganic & Medicinal Chemistry, 21 7: 1898-1904. doi:10.1016/j.bmc.2013.01.044
The ECMO PK Project: an incremental research approach to advance understanding of the pharmacokinetic alterations and improve patient outcomes during extracorporeal membrane oxygenation
Shekar, Kiran, Roberts, Jason A., Smith, Maree T., Fung, Yoke L. and Fraser, John F. (2013) The ECMO PK Project: an incremental research approach to advance understanding of the pharmacokinetic alterations and improve patient outcomes during extracorporeal membrane oxygenation. BMC Anesthesiology, 13 7.1-7.10. doi:10.1186/1471-2253-13-7
Optimization and characterization of a rat model of prostate cancer-induced bone pain using behavioural, pharmacological, radiological, histological and immunohistochemical methods
Muralidharan, Arjun, Wyse, Bruce D. and Smith, Maree T. (2013) Optimization and characterization of a rat model of prostate cancer-induced bone pain using behavioural, pharmacological, radiological, histological and immunohistochemical methods. Pharmacology Biochemistry and Behavior, 106 33-46. doi:10.1016/j.pbb.2013.02.020
ASAP ECMO: antibiotic, sedative and analgesic pharmacokinetics during extracorporeal membrane oxygenation: a multi-centre study to optimise drug therapy during ECMO
Shekar, Kiran, Roberts, Jason A., Welsh, Susan, Buscher, Hergen, Rudham, Sam, Burrows, Fay, Ghassabian, Sussan, Wallis, Steven C., Levkovich, Bianca, Pellegrino, Vin, McGuiness, Shay, Parke, Rachael, Gilder, Eileen, Barnett, Adrian G., Walsham, James, Mullany, Daniel V., Fung, Yoke L., Smith, Maree T. and Fraser, John F. (2012) ASAP ECMO: antibiotic, sedative and analgesic pharmacokinetics during extracorporeal membrane oxygenation: a multi-centre study to optimise drug therapy during ECMO. BMC Anesthesiology, 12 29.1-29.9. doi:10.1186/1471-2253-12-29
Sedation during extracorporeal membrane oxygenation-why more is less
Shekar, K., Roberts, J. A., Ghassabian, S., Mullany, D. V., Ziegenfuss, M., Smith, M. T., Fung, Y. L. and Fraser, J. F. (2012) Sedation during extracorporeal membrane oxygenation-why more is less.Anaesthesia and Intensive Care, 40 6: 1067-1069.
Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation: cause for concern?
Shekar, Kiran, Roberts, Jason A., Ghassabian, Sussan, Mullany, Daniel V., Wallis, Steven C., Smith, Maree T. and Fraser, John F. (2012) Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation: cause for concern?. Journal of Antimicrobial Chemotherapy, 68 3: 726-727. doi:10.1093/jac/dks435
Sequestration of drugs in the circuit may lead to therapeutic failure during extracorporeal membrane oxygenation
Shekar, Kiran, Roberts, Jason A., McDonald, Charles I., Fisquet, Stephanie, Barnett, Adrian G., Mullany, Daniel V., Ghassabian, Sussan, Wallis, Steven C., Fung, Yoke L., Smith, Maree T. and Fraser, John F. (2012) Sequestration of drugs in the circuit may lead to therapeutic failure during extracorporeal membrane oxygenation. Critical Care, 16 5: R194.1-R194.7. doi:10.1186/cc11679
Lipo-endomorphin-1 derivatives with systemic activity against neuropathic pain without producing constipation
Varamini, Pegah, Mansfeld, Friederike M., Blanchfield, Joanne T., Wyse, Bruce D., Smith, Maree T. and Toth, Istvan (2012) Lipo-endomorphin-1 derivatives with systemic activity against neuropathic pain without producing constipation. PLoS One, 7 8 Article. No.e41909: . doi:10.1371/journal.pone.0041909
High-throughput assay for simultaneous quantification of the plasma concentrations of morphine, fentanyl, midazolam and their major metabolites using automated SPE coupled to LC-MS/MS
Ghassabian, Sussan, Moosavi, Seyed Mojtaba, Valero, Yarmarly Guerra, Shekar, Kiran, Fraser, John F. and Smith, Maree T. (2012) High-throughput assay for simultaneous quantification of the plasma concentrations of morphine, fentanyl, midazolam and their major metabolites using automated SPE coupled to LC-MS/MS. Journal of Chromatography B, 903 126-133. doi:10.1016/j.jchromb.2012.07.005
Pregabalin for the treatment of fibromyalgia
Smith, Maree T. and Moore, Brendan J. (2012) Pregabalin for the treatment of fibromyalgia. Expert Opinion on Pharmacotherapy, 13 10: 1527-1533. doi:10.1517/14656566.2012.687373
Synthesis and biological evaluation of an orally active glycosylated endomorphin-1
Varamini, Pegah, Mansfeld, Friederike M., Blanchfield, Joanne T., Wyse, Bruce D., Smith, Maree T. and Toth, Istvan (2012) Synthesis and biological evaluation of an orally active glycosylated endomorphin-1. Journal of Medicinal Chemistry, 55 12: 5859-5867. doi:10.1021/jm300418d
Development of simulated and ovine models of extracorporeal life support to improve understanding of circuit-host interactions
Shekar, Kiran, Fung, Yoke L., Diab, Sara, Mullany, Daniel V., McDonald, Charles I, Dunster, Kimble R., Fisquet, Kimble R, Platts, David G., Stewart, David G, Wallis, Steven C., Smith, Maree T., Roberts, Jason A. and Fraser, John F. (2012) Development of simulated and ovine models of extracorporeal life support to improve understanding of circuit-host interactions. Critical Care and Resuscitation, 14 2: 105-111.
Development and validation of a sensitive solid-phase-extraction (SPE) method using high-performance liquid chromatography/tandem mass spectrometry (LC-MS/MS) for determination of risedronate concentrations in human plasma
Ghassabian, Sussan, Wright, Linda A., deJager, Andrew D. and Smith, Maree T. (2012) Development and validation of a sensitive solid-phase-extraction (SPE) method using high-performance liquid chromatography/tandem mass spectrometry (LC-MS/MS) for determination of risedronate concentrations in human plasma. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 881-82 34-41. doi:10.1016/j.jchromb.2011.11.031
Pharmacogenetics of pain and analgesia
Smith, M. T. and Muralidharan, A. (2012) Pharmacogenetics of pain and analgesia. Clinical Genetics,82 4: 321-330. doi:10.1111/j.1399-0004.2012.01936.x
Pharmacokinetic changes in patients receiving extracorporeal membrane oxygenation
Shekar, Kiran, Fraser, John F., Smith, Maree T. and Roberts, Jason A. (2012) Pharmacokinetic changes in patients receiving extracorporeal membrane oxygenation. Journal of Critical Care, 27 6: 741.e9-741.e18. doi:10.1016/j.jcrc.2012.02.013
Pain, analgesia and genetics
Muralidharan, Arjun and Smith, Maree T. (2011) Pain, analgesia and genetics. Journal of Pharmacy and Pharmacology, 63 11: 1387-1400. doi:10.1111/j.2042-7158.2011.01340.x
Pregabalin in severe burn injury pain: A double-blind, randomised placebo-controlled trial
Gray, Paul, Kirby, Julie, Smith, Maree T., Cabot, Peter J., Williams, Bronwyn, Doecke, James and Cramond, Tess (2011) Pregabalin in severe burn injury pain: A double-blind, randomised placebo-controlled trial. Pain, 152 6: 1279-1288. doi:10.1016/j.pain.2011.01.055
Insulin implants prevent the temporal development of mechanical allodynia and opioid hyposensitivity for 24-wks in streptozotocin (STZ)-diabetic wistar rats
Otto, Kathleen J., Wyse, Bruce D., Cabot, Peter J. and Smith, Maree T. (2011) Insulin implants prevent the temporal development of mechanical allodynia and opioid hyposensitivity for 24-wks in streptozotocin (STZ)-diabetic wistar rats. Pain Medicine, 12 5: 782-793. doi:10.1111/j.1526-4637.2011.01102.x
Longitudinal study of painful diabetic neuropathy in the Zucker diabetic fatty rat model of type 2 diabetes: Impaired basal G-protein activity appears to underpin marked morphine hyposensitivity at 6 months
Otto, Kathleen J., Wyse, Bruce D., Cabot, Peter J. and Smith, Maree T. (2011) Longitudinal study of painful diabetic neuropathy in the Zucker diabetic fatty rat model of type 2 diabetes: Impaired basal G-protein activity appears to underpin marked morphine hyposensitivity at 6 months. Pain Medicine,12 3: 437-450. doi:10.1111/j.1526-4637.2011.01067.x
PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models
Dredge, K, Hammond, E, Handley, P, Gonda, TJ, Smith, MT, Vincent, C, Brandt, R, Ferro, V and Bytheway, I (2011) PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models. British Journal of Cancer, 104 5: 635-642. doi:10.1038/bjc.2011.11
Smith, Maree T. and Muralidharan, Arjun (2010) Pharmacogenetics. Pain: Clinical Updates, 18 8: 1-8.
A randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin
Zin, Che S., Nissen, Lisa M., O'Callaghan, James P., Duffull, Stephen B., Smith, Maree T. and Moore, Brendan J. (2010) A randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin. Journal of Pain, 11 5: 462-471. doi:10.1016/j.jpain.2009.09.003
Preliminary study of the plasma and cerebrospinal fluid concentrations of IL-6 and IL-10 in patients with chronic pain receiving intrathecal opioid infusions by chronically implanted pump for pain management
Zin, Che S., Nissen, Lisa M., O'Callaghan, James P., Moore, Brendan J. and Smith, Maree T. (2010) Preliminary study of the plasma and cerebrospinal fluid concentrations of IL-6 and IL-10 in patients with chronic pain receiving intrathecal opioid infusions by chronically implanted pump for pain management. Pain Medicine, 11 4: 550-561. doi:10.1111/j.1526-4637.2010.00821.x
X-conopeptide pharmacophore development: Toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain
Brust, Andreas, Palant, Elka, Croker, Daniel E., Colless, Barbara, Drinkwater, Roger, Patterson, Brad, Schroeder, Christina I., Wilson, David, Nielsen, Carsten K., Smith, Maree T., Alewood, Danne, Alewood, Paul F and Lewis, Richard J. (2009) X-conopeptide pharmacophore development: Toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. Journal of Medicinal Chemistry,52 22: 6991-7002. doi:10.1021/jm9003413
Antinociception versus serum concentration relationships following acute administration of intravenous morphine in male and female Sprague-dawley rats: Differences between the tail flick and hot plate nociceptive tests
South, Samantha M., Edwards, Stephen R. and Smith, Maree T. (2009) Antinociception versus serum concentration relationships following acute administration of intravenous morphine in male and female Sprague-dawley rats: Differences between the tail flick and hot plate nociceptive tests. Clinical and Experimental Pharmacology and Physiology, 36 1: 20-28. doi:10.1111/j.1440-1681.2008.05019.x
Comparative studies of the neuro-excitatory behavioural effects of morphine-3-glucuronide and dynorphin A (2-17) following spinal and supraspinal routes of administration
Hemstapat, K., Le, L., Edwards, S. R. and Smith, M. T. (2009) Comparative studies of the neuro-excitatory behavioural effects of morphine-3-glucuronide and dynorphin A (2-17) following spinal and supraspinal routes of administration. Pharmacology, Biochemistry and Behaviour, 93 4: 498-505. doi:10.1016/j.pbb.2009.06.016
Innovation in drug development
Smith, M.T. (2009) Innovation in drug development. BioSpectrum Asia CRAMS Resources Guide, 52-53.
Differences between and combinations of opiods re-visited
Smith, Maree T. (2008) Differences between and combinations of opiods re-visited. Current Opinion in Anaesthesiology, 21 5: 596-601. doi:10.1097/ACO.0b013e32830a4c4a
An update on the pharmcological management of post-herpetic neuralgia and painful diabetic neuropathy
Zin, Che S., Nissen, Lisa M., Smith, Maree T., O'Callaghan, James P. and Moore, Brendan J. (2008) An update on the pharmcological management of post-herpetic neuralgia and painful diabetic neuropathy.CNS Drugs, 22 5: 417-442.
Sex differences in the pharmacokinetics, oxidative metabolism and oral bioactivity of oxycodone in the sprague-dawley rat
Chan, S., Edwards, S. R., Wyse, B. D. and Smith, M. T. (2008) Sex differences in the pharmacokinetics, oxidative metabolism and oral bioactivity of oxycodone in the sprague-dawley rat.Clinical and Experimental Pharmacology and Physiology, 35 3: 295-302. doi:10.1111/j.1440-1681.2007.04821.x
Studies with ketamine and alfentanil following Freund's complete adjuvant-induced inflammation in rats
Edwards, S. R., Mather, L. E. and Smith, M. T. (2007) Studies with ketamine and alfentanil following Freund's complete adjuvant-induced inflammation in rats. Clinical and Experimental Pharmacology and Physiology, 34 5-6: 414-420. doi:10.1111/j.1440-1681.2007.04581.x
Low-level quantitation of oxycodone and its oxidative metabolites, noroxycodone, and oxymorphone, in rat plasma by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry
Edwards, Stephen R. and Smith, Maree T. (2007) Low-level quantitation of oxycodone and its oxidative metabolites, noroxycodone, and oxymorphone, in rat plasma by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry. Journal of Chromatography B,848 2: 264-270. doi:10.1016/j.jchromb.2006.10.039
Oxycodone and morphine have distinctly different pharmacological profiles: Radioligand binding and behavioural studies in two rat models of neuropathic pain
Nielsen, Carsten K., Ross, Fraser B., Lotfipour, Shahrdad, Saini, Kamal S., Edwards, Stephen R. and Smith, Maree T. (2007) Oxycodone and morphine have distinctly different pharmacological profiles: Radioligand binding and behavioural studies in two rat models of neuropathic pain. Pain, 132 3: 289-300. doi:10.1016/j.pain.2007.03.022
Oxycodone's mechanism of action and potency differences after spinal and systemic routes of administration
Smith, Maree T., Edwards, Stephen R. and Nielsen, Carsten K. (2007) Oxycodone's mechanism of action and potency differences after spinal and systemic routes of administration. Anesthesiology, 1065: 1063-1064. doi:10.1097/01.anes.0000265176.75372.ed
Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain
Nielsen, Carsten K., Lewis, Richard J., Alewood, Dianne, Drinkwater, Roger, Palant, Elka, Patterson, Margaret, Yaksh, Tony L, McCumber, Damon and Smith, Maree T. (2005) Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain. Pain, 118 1-2: 112-124. doi:10.1016/j.pain.2005.08.002
Co-administration of oxycodone and morphine and analgesic synergy re-examined
Smith, MT and de la Iglesia, FA (2005) Co-administration of oxycodone and morphine and analgesic synergy re-examined. British Journal of Clinical Pharmacology, 59 4: 486-487. doi:10.1111/j.1365-2125.2005.02345_1.x
Comparison of the pharmacokinetics of oxycodone and noroxycodone in male dark agouti and Sprague-Dawley rats: Influence of streptozotocin-induced diabetes
Huang, L., Edwards, S. R. and Smith, M. T. (2005) Comparison of the pharmacokinetics of oxycodone and noroxycodone in male dark agouti and Sprague-Dawley rats: Influence of streptozotocin-induced diabetes. Pharmaceutical Research, 22 9: 1489-1498. doi:10.1007/s11095-005-6154-y
Simultaneous determination of morphine, oxycodone, morphine-3-glucuronide, and noroxycodone concentrations in rat serum by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry
Edwards, S. R. and Smith, M. T. (2005) Simultaneous determination of morphine, oxycodone, morphine-3-glucuronide, and noroxycodone concentrations in rat serum by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry. Journal of Chromatography B,814 2: 241-249. doi:10.1016/j.jchromb.2004.10.035
Ventilatory responses of healthy subjects to intravenous combinations of morphine and oxycodone under imposed hypercapnic and hypoxaemic conditions
Ladd, L. A., Kam, P. C., Williams, D. B., Wright, A. W. E., Smith, M. T. and Mather, L. E. (2005) Ventilatory responses of healthy subjects to intravenous combinations of morphine and oxycodone under imposed hypercapnic and hypoxaemic conditions. British Journal of Clinical Pharmacology, 59 5: 524-535. doi:10.1111/j.1365-2125.2005.02368.x
Deletion of guanine nucleotide binding protein az subunit in mice induces a gene dose dependent tolerance to morphine
Leck, KJ, Bartlett, SE, Smith, MT, Megirian, D, Holgate, J, Powell, KL, Matthaei, KI and Hendry, IA (2004) Deletion of guanine nucleotide binding protein az subunit in mice induces a gene dose dependent tolerance to morphine. Neuropharmacology, 46 6: 836-846. doi:10.1016/j.neuropharm.2003.11.024
Measurement of intracellular Ca2+ in cultured rat embryonic hippocampal neurons using a fluorescence microplate reader: Potential application to biomolecular screeningHemstapat, K, Smith, M. T. and Monteith, G. R. (2004) Measurement of intracellular Ca2+ in cultured rat embryonic hippocampal neurons using a fluorescence microplate reader: Potential application to biomolecular screening. Journal of Pharmacological and Toxicological Methods, 49 2: 81-87. doi:10.1016/j.vascn.2003.10.002
Morphine-3-glucuronide's neuro-excitatory effects are mediated via indirect activation of N-methyl-D-aspartic acid receptors: Mechanistic studies in embryonic cultured hippocampal neurones
Hemstapat, K., Monteith, G. R., Smith, D. and Smith, M. T. (2003) Morphine-3-glucuronide's neuro-excitatory effects are mediated via indirect activation of N-methyl-D-aspartic acid receptors: Mechanistic studies in embryonic cultured hippocampal neurones. Anesthesia & Analgesia, 97 2: 494-505. doi:10.1213/01.ANE.0000059225.40049.99
Managing diabetic neuropathy
Smith, M. T. (2003) Managing diabetic neuropathy. Australian Pharmacist, 22 10: 782-787.
The neuroexcitatory morphine metabolite, morphine-3-glucuronide (M3G), is not neurotoxic in primary cultures of either hippocampal or cerebellar granule neurones
Hemstapat, K., Smith, S. A., Monteith, G. R. and Smith, M. T. (2003) The neuroexcitatory morphine metabolite, morphine-3-glucuronide (M3G), is not neurotoxic in primary cultures of either hippocampal or cerebellar granule neurones. Pharmacology & Toxicology, 93 4: 197-200. doi:10.1034/j.1600-0773.2003.930408.x
The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes
Wei, M., Ong, L., Smith, M. T., Ross, F. B., Schmid, K., Hoey, A., Burstow, D. J. and Brown, L. C. (2003) The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes.Heart, Lung and Circulation, 2003 12: 44-50.
The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices.
Smith, M. T., Cabot, P. J., Ross, F. B., Robertson, A. D. and Lewis, R. J. (2002) The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices.. Pain, 96 1-2: 119-127. doi:10.1016/S0304-3959(01)00436-5
Sex-related differences in antinociception and tolerance development following chronic intravenous infusion of morphine in the rat: modulatory role of testosterone via morphine clearance
South, Samantha M., Wright, Andrew W. E., Lau, Michael, Mather, Laurence E. and Smith, Maree T. (2001) Sex-related differences in antinociception and tolerance development following chronic intravenous infusion of morphine in the rat: modulatory role of testosterone via morphine clearance.Journal of Pharmacology and Experimental Therapeutics, 297 1: 446-457.
Analgesic tolerance to opioids
South, S. M. and Smith, M. T. (2001) Analgesic tolerance to opioids. Pain: Clinical Updates, 9 5: 1-4.
Hydromorphone-3-glucuronide - A more potent neuro-excitant than its structural analogue, morphine-3-glucuronide
Wright, AWE, Mather, LE and Smith, MT (2001) Hydromorphone-3-glucuronide - A more potent neuro-excitant than its structural analogue, morphine-3-glucuronide. Life Sciences, 69 4: 409-420. doi:10.1016/S0024-3205(01)01133-X
Opioid analgesic prescribing and use - an audit of analgesic prescribing by general practitioners and The Multidisciplinary Pain Centre at Royal Brisbane Hospital
Nissen, L. M., Tett, S. E., Cramond, T., Williams, B. and Smith, M. T. (2001) Opioid analgesic prescribing and use - an audit of analgesic prescribing by general practitioners and The Multidisciplinary Pain Centre at Royal Brisbane Hospital. British Journal of Clinical Pharmacology, 52 6: 693-698. doi:10.1046/j.0306-5251.2001.01502.x
The role of morphine-6-glucuronide (M6G) in pain control
Smith, Maree T. and South, Samantha M. (2001) The role of morphine-6-glucuronide (M6G) in pain control. Pain Reviews, 8 3-4: 171-191. doi:10.1191/0968130201pr183ra
Co-administration of sub-antinociceptive doses of oxycodone and morphine produces marked antinociceptive synergy with reduced CNS side-effects in rats
Ross, Fraser B., Wallis, Steven C. and Smith, Maree T. (2000) Co-administration of sub-antinociceptive doses of oxycodone and morphine produces marked antinociceptive synergy with reduced CNS side-effects in rats. Pain, 84 2-3: 421-428. doi:10.1016/S0304-3959(99)00230-4
Incomplete, asymmetric, and route-dependent cross-tolerance between oxycodone and morphine in the Dark Agouti rat
Nielsen, C. K., Ross, F. B. and Smith, M. T. (2000) Incomplete, asymmetric, and route-dependent cross-tolerance between oxycodone and morphine in the Dark Agouti rat. Journal of Pharmacology and Experimental Therapeutics, 295 1: 91-99.
Neuroexcitatory effects of morphine and hydromorphone: Evidence implicating the 3-glucuronide metabolites
Smith, MT (2000) Neuroexcitatory effects of morphine and hydromorphone: Evidence implicating the 3-glucuronide metabolites. Clinical and Experimental Pharmacology and Physiology, 27 7: 524-528. doi:10.1046/j.1440-1681.2000.03290.x
Systemic coadministration of chloramphenicol with intravenous but not intracerebroventricular morphine markedly increases morphine antinociception and delays development of antinociceptive tolerance in rats
Smith, M. T., Nielsen, C. K., Lim-Fraser, M. Y. C., Wright, A. W. E. and Lau, M. (2000) Systemic coadministration of chloramphenicol with intravenous but not intracerebroventricular morphine markedly increases morphine antinociception and delays development of antinociceptive tolerance in rats. Drug Metabolism And Disposition, 28 2: 236-244.
Brain region-specific studies of the excitatory behavioral effects of morphine-3-glucuronide
Halliday, Andrew J., Bartlett, Selena E., Colditz, Paul and Smith, Maree T. (1999) Brain region-specific studies of the excitatory behavioral effects of morphine-3-glucuronide. Life Sciences, 65 2: 225-236. doi:10.1016/S0024-3205(99)00239-8
Cerebrospinal fluid and plasma concentrations of morphine, morphine-3-glucuronide, and morphine-6-glucuronide in patients before and after initiation of intracerebroventricular morphine for cancer pain management
Smith, M. T., Wright, A. W., Williams, B., Stuart, G. and Cramond, T. R. (1999) Cerebrospinal fluid and plasma concentrations of morphine, morphine-3-glucuronide, and morphine-6-glucuronide in patients before and after initiation of intracerebroventricular morphine for cancer pain management. Anesthesia and analgesia, 88 1: 109-116. doi:10.1097/00000539-199901000-00021
Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis
Keates, Helen L., Cramond, Teresa and Smith, Maree T. (1999) Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis. Anesthesia and Analgesia, 89 2: 409-415.
Keates, HL, Cramond, T and Smith, MT (1999) Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis. Anesthesia and Analgesia, 89 2: 409-415. doi:10.1097/00000539-199908000-00030
Apparent insensitivity of the hotplate latency test for detection of antinociception following intraperitoneal, intravenous or intracerebroventricular M6G administration to rats
South, SM and Smith, MT (1998) Apparent insensitivity of the hotplate latency test for detection of antinociception following intraperitoneal, intravenous or intracerebroventricular M6G administration to rats. Journal of Pharmacology And Experimental Therapeutics, 286 3: 1326-1332.
Hydromorphone-3-glucuronide: Biochemical synthesis and preliminary pharmacological evaluation
Wright, AWE, Nocente, ML and Smith, MT (1998) Hydromorphone-3-glucuronide: Biochemical synthesis and preliminary pharmacological evaluation. Life Sciences, 63 5: 401-411. doi:10.1016/S0024-3205(98)00288-4
Improved one-step solid-phase extraction method for morphine, morphine-3-glucuronide, and morphine-6-glucuronide from plasma and quantitation using high-performance liquid chromatography with electrochemical detection
Wright, AWE and Smith, MT (1998) Improved one-step solid-phase extraction method for morphine, morphine-3-glucuronide, and morphine-6-glucuronide from plasma and quantitation using high-performance liquid chromatography with electrochemical detection. Therapeutic Drug Monitoring, 20 2: 215-218. doi:10.1097/00007691-199804000-00013
Investigation of the antinociceptive efficacy and relative potency of extended duration injectable 3-acylmorphine-6-sulfate prodrugs in rats
Preechagoon, D, Smith, MT and Prankerd, RJ (1998) Investigation of the antinociceptive efficacy and relative potency of extended duration injectable 3-acylmorphine-6-sulfate prodrugs in rats. International Journal of Pharmaceutics, 163 1-2: 191-201. doi:10.1016/S0378-5173(97)00380-3
Solid-phase extraction method with high-performance liquid chromatography and electrochemical detection for the quantitative analysis of oxycodone in human plasma
Wright, AWE, Lawrence, JA, Iu, M, Cramond, T and Smith, MT (1998) Solid-phase extraction method with high-performance liquid chromatography and electrochemical detection for the quantitative analysis of oxycodone in human plasma. Journal of Chromatography B, 712 1-2: 169-175. doi:10.1016/S0378-4347(98)00146-7
The excitatory behavioral and antianalgesic pharmacology of normorphine-3-glucuronide after intracerebroventricular administration to rats
Smith, GD and Smith, MT (1998) The excitatory behavioral and antianalgesic pharmacology of normorphine-3-glucuronide after intracerebroventricular administration to rats. Journal of Pharmacology And Experimental Therapeutics, 285 3: 1157-1162.
Biochemical synthesis, purification and preliminary pharmacological evaluation of normorphine-3-glucuronide
Smith, GD, Prankerd, RJ and Smith, MT (1997) Biochemical synthesis, purification and preliminary pharmacological evaluation of normorphine-3-glucuronide. Life Sciences, 61 2: 95-104. doi:10.1016/S0024-3205(97)00364-0
Morphine has a dual concentration-dependent effect on K+-evoked substance P release from rat peripheral airways
Cabot, PJ, Cramond, T and Smith, MT (1997) Morphine has a dual concentration-dependent effect on K+-evoked substance P release from rat peripheral airways. Pulmonary Pharmacology & Therapeutics,10 4: 215-221. doi:10.1006/pupt.1997.0094
The intrinsic antinociceptive effects of oxycodone appear to be kappa-opioid receptor mediated
Ross, FB and Smith, MT (1997) The intrinsic antinociceptive effects of oxycodone appear to be kappa-opioid receptor mediated. Pain, 73 2: 151-157. doi:10.1016/S0304-3959(97)00093-6
Quantitative autoradiography of peripheral opioid binding sites in rat lung
Cabot, PJ, Cramond, T and Smith, MT (1996) Quantitative autoradiography of peripheral opioid binding sites in rat lung. European Journal of Pharmacology, 310 1: 47-53. doi:10.1016/0014-2999(96)00363-9
Pharmacology of Morphine and Morphine-3-Glucuronide At Opioid, Excitatory Amino-Acid, Gaba and Glycine Binding-Sites
Bartlett, SE, Dodd, PR and Smith, MT (1994) Pharmacology of Morphine and Morphine-3-Glucuronide At Opioid, Excitatory Amino-Acid, Gaba and Glycine Binding-Sites. Pharmacology & Toxicology, 75 2: 73-81.
Characterization of Nonconventional Opioid Binding-Sites in Rat and Human Lung
Cabot, PJ, Dodd, PR, Cramond, T and Smith, MT (1994) Characterization of Nonconventional Opioid Binding-Sites in Rat and Human Lung. European Journal of Pharmacology-Molecular Pharmacology Section, 268 2: 247-255. doi:10.1016/0922-4106(94)90195-3
Pathophysiology of neuropathic pain and chronic inflammatory pain
Efficacy profiling of new molecules with potential as novel analgesics for treatment of neuropathic pain or chronic inflammatory pain
MS-associated central neuropathic pain
Painful diabetic neuropathy
Cancer chemotherapy-induced peripheral neuropathy
Mechanical low back pain
Osteoarthritis pain
Advisors/co-advisors: Professor Maree Smith, Dr Andy Kuo
Note for students: Please contact us as the research projects listed on this page are examples only. Please always feel free to contact the staff for more information, and also with your own research ideas.
Mining the host-pathogen interface to deliver a drug pipeline for treating intractable and emerging infections
(2022–2026) NHMRC Synergy Grants
Novel long-acting and orally delivered conotoxin-based peptides with both analgesic efficacy and disease modifying potential
(2022–2024) NHMRC Development Grant
Assess the clinical disease-modifying effects of one peptide test item given twice-weekly for 3 weeks relative to sham control and vehicle in the relapsing-remitting experimental autoimmune encephalom
(2022–2023) Argenica Therapeutics Limited
Developing novel acid-sensing ion channel inhibitors as neuroprotective leads and diagnostic agents for multiple sclerosis
(2022–2023) Multiple Sclerosis Research Australia - Targeted Grant - Neurodegeneration
Neuroprotective role of novel acid-sensing ion channel inhibitor in Multiple sclerosis (MS) disease
(2020–2022) Multiple Sclerosis Research Australia
Development of a first-in-class neuroprotective drug for protecting the brain after stroke
Advanced Brightfield and Fluorescent High Speed and Throughput Slide Scanner for biological, medical, materials science, and agricultural applications
(2019) UQ Major Equipment and Infrastructure
Vevo 3100 Imaging System for ultrahigh resolution and frame rate echocardiographic assessment of small animals.
Novel non-opioid analgesics
High-throughput ion channel pharmacology
The impact of extracorporeal membrane oxygenation (ECMO) on the activities of drug enzymes that affect the pharmacokinetics and therapeutic outcomes of clinically important drugs
(2017–2018) Prince Charles Hospital Foundation
Novel prolonged-release polymeric microparticles for relief of intractable cancer-related pain
(2016–2018) NHMRC Project Grant
Novel Pain therapeutics discovery: Probing molecular mechanisms
(2016) NHMRC Equipment Grant
ACRF Facility for Molecular Imaging Agents in Cancer (AFMIAC)
(2015–2022) Australian Cancer Research Foundation
INK-004 Preliminary assessment of the analgesic efficacy of one test item following intrathecal bolus administration in a rat model of peripheral neuropathic pain
(2015–2016) UniQuest Pty Ltd
Novel analgesics for improved relief of cancer induced bone pain
(2015) UQ Collaboration and Industry Engagement Fund
Developing subtype-selective blockers of acid-sensing ion channels for treating peripheral pain
Translating Health Discovery (THD) - NCRIS 2013/2015/2016-17 (administered by Therapeutic Innovation Australia (TIA))
(2014–2017) Therapeutic Innovation Australia Limited
PHG-003 - Preparation of manuscript encompassing the data generated in studies PHG-001 and PHG-002 for publication in an international peer-reviewed journal
Efficacy Profiling Innovation in Novel Pain Therapeutics Discovery
(2013–2016) ARC Linkage Projects
Investigations into the pain relief properties of Komipharm's test compound
Oral EMA401 mode of action study in a rat model of post-herpetic neralgia (PHN)
(2013–2015) Spinifex Pharmaceuticals Pty Ltd
High throughput electrophysiology platform
Translating health discoveries into products
(2011–2015) Queensland Government Smart Futures Co-Investment Fund
Therapeutic Innovation Australia - Queensland node (Source of funds: EIF)
Development of chaperonin 10-based second generation biopharmaceuticals for treatment of inflammatory diseases
Novel polymeric microparticles for slow-release intrathecal delivery of analgesics
Development of high throughput in-vitro test methods for screening sensitization potential of industrial chemicals
(2010–2012) UQ Collaboration and Industry Engagement Fund
Cost effective acquisition of an LC-MS/MS system to support CIPDD organics analysis and preclinical and clinical operations
High content imaging analysis for bioactive and novel therapeutic target evaluation
Alzheimer's disease: Novel MRI Biomarkers for Clinical Diagnosis and Translational Studies
(2009–2013) Queensland Government Smart State National and International Research Alliances Program
Systematic evaluation of whether in vitro methods can predict in vivo opioid analgesic efficacy, safety and teolerability
(2009–2010) Alchemia Pty Ltd
Investigation of the relationship between cytokine levels and opioid analgesics in patients with chronic non-cancer pain receiving long term intrathecal opioid therapy for pain management
(2008) Gallipoli Research Foundation
Novel therapeutic for treating painful diabetic neuropathy
(2008) Diabetes Australia Research Trust
Systematic evaluation of whether in vitro methods can predict in vivo opioid analgesic efficacy, safety and tolerability
Investigation of whether a small dose of Oxycodone enhances the efficacy and/or tolerability of orally administered pregabalin in patients with either post-herpetic neuralgia (PHN) or painful diabetic
(2006–2007) Gallipoli Research Foundation
Advanced Cell Labelling and Imaging Facility
(2006) ARC Linkage Infrastructure, Equipment and Facilities
NHMRC_Equipment Grant = DSI Telemetry System
NHMRC_Equipment Grant_HLTH_Pharmacy
(2004–2005) NHMRC Equipment Grant
The analgesic evaluation of novel natural products from the Australian plant Barringtonia acutangula
(2004–2005) Griffith University
Malvern Zetasizer 3000HS
Pharmacological investigation of the toxicological effects of high doses of systemic morphine
(2002–2003) Queensland Cancer Fund
Lipid and liposaccharide based drug delivery systems
(2001–2004) Wellcome Trust
Prevention of chronic complications in the STZ-diabetic rat
(2001–2002) Mayne Bequest Fund
A biohazard laminar flow hood for neuronal cell cultures:partial cost recovery from emergency purchase
(2001) Brain Research Fund
Efficacy of oxycodone for relief of neuropathic pain
(2000) Pharmaceutical Society of Australia
Efficacy of oxycodone relative to morphine for the relief of neuropathic pain in rats
A novel liposaccharide based system for drug/peptide delivery
The use of fluorescence microscopy to investigate the role of the calcium pump in disease and the mechanism of excitatory side effects by high dose morphine
(1999) Ramaciotti Foundation
M3G: Further Studies of its CNS Pharmacology
Further investigation of morphine 3-glucuronide's role in the dose-limiting excitatory side-effects of morphine administered chronically to cancer patients
Evaluating morphine for intra-articular analgesia in dogs using forceplate platform technology
(1996) John & Mary Kibble Trust
Functional characterisation of opioid binding sites in rat airways
(1996) ARC Australian Research Council (Small grants)
Investigation of the CNS mechanisms involved in the excitatory side-effects of Morphine in cancer pain management
Sustained release of novel injectable analgesic agents - a pharmacological evaluation in rats
The mission of the TIA is to provide a facilitated pathway to assist Australian life sciences discovery researchers to progress their inventions through the various nonclinical & clinical development steps to the point where they will attract investment for commercialization into products for improving human health.
For more information please visit the Therapeutic Innovation website.
CIPDD is one of four TIA-funded National translational research Centres that comprise the Small Molecule Therapeutics capability. The other three Centres are Compounds Australia, the Australian Translational Medicinal Chemistry Facility and the Centre for Drug Candidate Optimisation.
The National Collaborative Research Infrastructure Strategy drives research excellence and collaboration between 35,000 researchers, government and industry to deliver practical outcomes.
Learn more about the NCRIS.
F: +61 7 3346 7391
E: maree.smith@uq.edu.au
E: a.kuo1@uq.edu.au
Mailing/Delivery Address
Level 3 Steele Building, St. Lucia campus, Staffhouse Rd


text:
Jacksonville MABL Opens Up in Quality Fashion in Florida
By Men's Senior Baseball League | July 7, 2020
There is a talent pool in Jacksonville, Florida known as the Jacksonville MABL. As evidenced by the name, the MABL league is technically an 18-over league and has become even stronger thanks to the pandemic. We'll let league president Joe Hellett explain
"This league has been around since the late 80's in the traditional 30-over format but we added the 18-over element in the mid-90's and it has stayed there ever since," said Hellett. "Our average age is in the mid-20's, though we have some players in their 50's."
A mid-20 average age is enough to put shivers up and down this old 60-plus spine, as my bat speed is well below what is needed to turn on any 90+ fastball, but as the commercial says, 'wait, there's more'!
"We were the beneficiary of no college or minor league baseball being played because of the pandemic so many players decided to play with us. To say that we have the best possible quality baseball in the area is an understatement."
Yikes! I would pay admission to watch this MABL league play.
"We started on June 24th and hope to end in August with playoffs in September," said Hellett. "However, summer weather in Florida can produce daily rain so you never know what will happen to your schedule. We usually have two sessions, regularly beginning mid-April with playoffs in August, followed by a ten-game fall season from mid-September to Thanksgiving. We don't get a ton of teams in the fall because football is so crazy down here but this year will be a little different, I think."
How has the pandemic affected the way these young horses feel about playing baseball in Jacksonville?
"It's really pretty simple. There are just a few things we needed to monitor, since these guys are all about straight-up baseball. One, if you're sick you can't play and you need to take a couple of weeks off and then show you are OK. You can wear a mask if you wish but it is not mandatory. Lastly, keep your social distancing as best you can in the dugout. There are no strict rules about that, we just encourage you to be smart. It's too darn hot in Florida to wear a mask on the field so that was voted down but we do see some guys wearing them on the sidelines.
The umpires can also wear a mask if they wish. We actually started with the umpires standing behind the pitcher's mound but with the quality of these players it became dangerous to be standing out there. That experiment ended quickly and thankfully without incident!"
Joe took over as president in 2014 and all games are located right there I Jacksonville on Wednesday and Sunday evenings. The 30-over division was attempted again last year with the hope to possibly attract players from other counties but it didn't go as planned so they abandoned the idea.
"We found that the older division was filled with guys who were old enough to play but were playing on other teams in our MABL division. We really weren't attracting anyone new and only supplying another format for them to play. We decided to just leave it alone for now, at least until some of the players wish to go to the older division exclusively."
Joe remains the player/manager of the Indians while holding down third base. He also attends the MSBL Fall Classic in Florida on occasion.
"The last time I went was in 2015 but look forward to getting back there. A lot of our players take part. It's a great time, if we can pull our players away from football and the NFL Jaguars for a little while!"
Joe is a high school social studies teacher, which is why it is a little tougher for him to get away for fall tournaments. But this down time has given him the time to concentrate on the league and the rules set forth by the county and state as he strives to make the baseball experience as normal and exciting as always.
"I concentrate, as always, on making this league the best it can be, at all times. We attract quality teams and that is our focus: quality and top-notch competition. The sheer number of players who come back year after year is a testament to the league. There are no other leagues like ours nearby. I guess after over 30 years of being in existence we must be doing something right. I sure hope so.
We just try to provide quality, competitive baseball and I think our league is better than ever, especially this year!"

redpajama_set_name: RedPajamaCommonCrawl


RCSB PDB - 5A2O: Crystal structure of the nitrate transporter NRT1.1 from Arabidopsis thaliana in complex with nitrate.
Crystal structure of the nitrate transporter NRT1.1 from Arabidopsis thaliana in complex with nitrate.
Deposition Author(s): Parker, J.L., Newstead, S.
Molecular Basis of Nitrate Uptake by the Plant Nitrate Transporter Nrt1.1.
The NRT1/PTR family of proton-coupled transporters are responsible for nitrogen assimilation in eukaryotes and bacteria through the uptake of peptides. However, in most plant species members of this family have evolved to transport nitrate as well as additional secondary metabolites and hormones. In response to falling nitrate levels, NRT1.1 is phosphorylated on an intracellular threonine that switches the transporter from a low-affinity to high-affinity state. Here we present both the apo and nitrate-bound crystal structures of Arabidopsis thaliana NRT1.1, which together with in vitro binding and transport data identify a key role for His 356 in nitrate binding. Our data support a model whereby phosphorylation increases structural flexibility and in turn the rate of transport. Comparison with peptide transporters further reveals how the NRT1/PTR family has evolved to recognize diverse nitrogenous ligands, while maintaining elements of a conserved coupling mechanism within this superfamily of nutrient transporters.


text:
Watercolours 35
Collage 2
Social History 1
Taranaki Wars
Portraits 908
Individual 586
New Zealand Wars 401
First Taranaki War 271
Second Taranaki War 242
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"Untitled"
Pencil and ink sketch of a seated nude figure. The figure looks downwards and reaches arm to the ground. The paper for the sketch has been torn out of an instruction manual and is an example of Morris' practice of using found paper and objects in his artworks.
PA2012.059
"Mt Egmont. The Cottage"
Watercolour by Bernard Aris depicting a view of Taranaki taken from the slopes of Mt Taranaki/Egmont. Brown cottage with red roof in left foreground (depicted from the rear), a corrogated iron shed is situated lower down the slopes. Large, possibly dead, tree to right of cottage in foreground. Beyond the buildings is a view of Taranaki farm land and Mt Ruapehu.
A75.629
"Famous Jersey of Montgomery's Is N.Z. Made ..."
Cartoon about various animals and people taking the credit for the woollen jersey Field Marshal Montgomery was photographed wearing in Cairo during WWII.
"Happy Ending"
Cartoon depicting Hitler and several German officers along with a Japanese ally under seige in a bunker.
"Doors of Perception Management"
Drawing of india ink on exposed photographic paper. The drawing shows a tangled web of lines representing perceptions moving through a rectangular shape which represents one of the World Trade Center towers.
Etching of a human figure on paper printed with the Defense Department organization chart. The source for the chart is given as the "U.S. Organization Manual 1983/84". The human figure huddles into itself, holding a baby to its chest in a tight embrace. Morris uses the combination of this human figure with the Defense Department chart to explore the concept of humanity. He believes that for someone to be capable of pulling a trigger, they must have lost their humanity and forgotten the love that exists between parent and child.
Hand-carved stamp of a stylised human figure on a black ground.
"Taranaki (New Plymouth). The Village-Capital of the Province of New Plymouth, North Island, New Zealand"
Depicts scattered residences in New Plymouth from seaward end of Liardet Street. Methodist Church (right), Marsland Hill with barracks and St Mary's (right) with Mt Taranaki/Egmont and Pouakai in background.
"Taranaki's first Registered Electrical Business Cnr Brougham & Powderham Streets. Mid 20th Century."
Watercolour painting made from a 1930s photograph of the Smart Bros. Ltd. plumbing, tinsmithing, and electrical company premises on corner of Brougham and Powderham Streets, New Plymouth. The painting shows the large building with a red roof and a sign on the left side that reads 'SMART BROS. LTD. OFFICES, STORE ROOMS' and another sign on the right that reads 'SMART BROS. LTD. [PLUMBING ELECTRICAL (partially visible)]. There are two large power poles in front of the building on either side of the corner, and several vehicles parked along the street on the left and one on the right. There is a man visible in the shop window on the right wearing a blue shirt and blue overalls. He has been identified as Leslie Allen Smart, son of Allan Kiddy Smart (one of the original three Smart brothers along with George and Herbert) and father of Brian Smart, who commissioned the painting. The dog sitting outside the building in the centre of the image has been identified as Skip, who belonged to Arthur Lawrence Smart. The painting is framed with a beige mat with the title included in it and a mottled brown and gold frame.
George Smart established his business in Stratford in 1892 and was joined by his brothers when he expanded into New Plymouth. Allan Smart was one of the first registered electricians in New Plymouth. The company ran until c1957.
Waitara Freezing Works
Silver gelatin photograph of the Waitara Freezing Works mounted on card. The large weatherboard-clad building has a fence running along the left side with bushes in front and a tree in the background on the right. There is a dog standing on the left on a path that runs along the front of the building.
William Bolland Davies' home on Frankley Road
Photograph of William Bolland Davies' homestead on Frankley Road, New Plymouth. The house is seen surrounded by bush with sheds and a fence visible on the left. There are three people and a dog standing in front of the house, a person in white standing to the left of the house, another person standing further to the left, and another person standing on the hill to the left of the house.
Taranaki Rifle Volunteers including Victor Caddy Davies
Military photograph with 13 men in full military uniform standing in front of a group of trees. Two of the men are carrying flags and the others are carrying bayonets. Victor Caddy Davies is thrid from the right in the front row. The uniform he is wearing is also part of Puke Ariki's collection.
"Dr Hutchinson's whare Taramoukou Valley"
Photograph of two men standing at the front of a whare with bush in the background. A dog looking back at them is at the forefront of the image. The whare is made of wooden slatted walls with a straw-like material for the roof.
"The young Archduke Maximilien-Franz of Austria tending his cabbage patch (beneath a cabbage tree in Taranaki - c1800) in readiness for making a year's supply of sauerkraut."
Monochrome ink drawing by Stratford-born artist Graham Percy. The drawing depicts an imaginary scene in Taranaki where a young Archduke Maximilien-Franz of Austria is tending to a large crop of cabbages beneath a cabbage tree. The Archduke is dressed in a coat with large cuffs, pockets, and front panels over a shirt with frilled sleeves and breeches. His hair is styled in a late 18th Century fashion. He is standing amongst the cabbages with his feet hidden in the crop and is holding a garden tool in both hands. Behind the Archduke is a fence made of bound sticks, and the slope of Mount Taranaki is just visible in the background.
The drawing is part of Graham Percy's 'Imagined Histories' series from 2005, which follows a group of unlikely early settlers cultivating the land in an imaginary pre-European New Zealand. Other works in the series show two young Austrian Archduchesses playing in Taranaki's famous black sands and an Austrian Empress and her son celebrating the opening of their cake shop in Opunake.
The drawing was included in the exhibition "The Imaginative Life and Times of Graham Percy" that was shown at Puke Ariki from April 26 to June 8 2014 and also toured around over venues in New Zealand.
Devon Street and relocation of the Native Office
Black and white photographic image depicting a view of Devon Street, New Plymouth from the Currie Street corner showing the Native Office being removed from Lower Brougham Street.
"New Zealand: Encampment on Mount Eliot, New Plymouth"
View of New Plymouth looking west down Devon Street from about Liardet Street. Paritutu in the distance with military camp of 58th Regiment on Mount Eliot in right middle distance. Foreground figures include two horse riders, five Maori, and a dray. 58th Regiment established on Mount Eliot. Just landed from the "Duke of Portland" at anchor. The mail steamer "Zingari" is seen approaching from the south and is being signalled from the Mount Eliot mast.
Inglewood Primary School Queen Carnival
Princesses and Queen of the 1936 Inglewood Primary School Queen Carnival. Pictured left to right: Sybil Bennett, Peggy Alleman (Queen), Barbara Grant and Agnes Lovell (now Brabin, aged 7 in picture). The carnival was a fundraising event where the parents of the four princesses had to raise money and the princess whose family raised the most money was crowned Queen. All four girls are wearing long dresses and holding flowers. The Queen has a crown on her head and wears a long cloak. Cups that were presented to each girl are placed at their feet. Carnival was held in the Inglewood Town Hall.
PHO2009-134
"Bank of New Zealand, Waitara"
Ink and watercolour sketch of the Bank of New Zealand building in Waitara. The building is rendered in green with grey columns and a large red door, with the outlines and details sketched loosely in black ink. The building was built in 1876 and demolished in the 1960s.
"New Plymouth 1850-1856"
Pencil sketch of New Plymouth township in 1850-1856. The view looks down the Huatoki Stream to Devon Street Bridge. Marsland Hill and Mount Taranaki are visible in the background.
"Col. G.J. Carey"
Copy photograph of Colonel G.J. Carey. Carey was Second in Charge of the Imperial Forces in New Zealand in 1861. He is shown from the chest up with his photograph cut out and pasted onto a round piece of paper. Carey appears to be wearing military uniform and he has a moustache and full beard. The photograph is included on page 27 of William Francis Robert Gordon's album "Some "Soldiers of the Queen" who served in the Maori Wars and Other Notable Persons Connected Herewith".
Colours and Battle Honours of the 14th (Buckinghamshire) Regiment of Foot
Painted version of the colours and battle honours of the 14th (Buckinghamshire) Regiment of Foot of the British Army.
Untitled [Clock Tower]
Pencil sketch of New Plymouth's clock tower with other buildings in the foreground. A crane is also visible upper right of drawing. Several figures are visible in the foreground. The original clock tower was demolished in April 1969.
Drawing of a female nude which Morris has dubbed a "two-minute drawing". The drawing dates from when Morris was attending life-drawing workshops at Vincents Art Workshop in Wellington.
Drawing of a seated female nude which Morris has dubbed a "five-minute drawing". There is another drawing of a nude, seen from behind, on the reverse of the drawing. The drawings date from when Morris was attending life-drawing workshops at Vincents Art Workshop in Wellington.
Doubled sided artwork with a drawing of a nude figure on both sides. Morris has dubbed the drawings "two-minute drawings". The drawings date from when Morris was attending life-drawing workshops at Vincents Art Workshop in Wellington.