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Kim Michele Richardson
About Kim Michele Richardson
NYT and USA TODAY and L. A. TIMES bestselling author, Kim Michele Richardson resides in her home state of Kentucky. She is the author of the bestselling memoir The Unbreakable Child. Her novels include Liar's Bench, GodPretty in the Tobacco Field. The Sisters of Glass Ferry and The Book Woman of Troublesome Creek. Kim Michele latest novel, The Book Woman's Daughter, is both a standalone and sequel to The Book Woman of Troublesome Creek.
You can visit her websites and learn more at:
www.kimmichelerichardson.com
Donna Everhart
Ellen Marie Wiseman
Leah Weiss
Kelly Mustian
William Kent Krueger
Barbara Davis
Books By Kim Michele Richardson
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The Book Woman of Troublesome Creek: A Novel 7 May, 2019
by Kim Michele Richardson
₹ 949.05 ₹ 1,385.06
RECOMMENDED BY DOLLY PARTON IN PEOPLE MAGAZINE!
A USA TODAY BESTSELLER
A LOS ANGELES TIMES BESTSELLER
A PBS BOOK PICK
The bestselling historical fiction novel from Kim Michele Richardson, this is a novel following Cussy Mary, a packhorse librarian and her quest to bring books to the Appalachian community she loves, perfect for readers of William Kent Kreuger and Lisa Wingate. The perfect addition to your next book club!
The hardscrabble folks of Troublesome Creek have to scrap for everything—everything except books, that is. Thanks to Roosevelt's Kentucky Pack Horse Library Project, Troublesome's got its very own traveling librarian, Cussy Mary Carter.
Cussy's not only a book woman, however, she's also the last of her kind, her skin a shade of blue unlike most anyone else. Not everyone is keen on Cussy's family or the Library Project, and a Blue is often blamed for any whiff of trouble. If Cussy wants to bring the joy of books to the hill folks, she's going to have to confront prejudice as old as the Appalachias and suspicion as deep as the holler.
Inspired by the true blue-skinned people of Kentucky and the brave and dedicated Kentucky Pack Horse library service of the 1930s, The Book Woman of Troublesome Creek is a story of raw courage, fierce strength, and one woman's belief that books can carry us anywhere—even back home.
Look for The Book Woman's Daughter, the next novel from Kim Michele Richardson coming in May 2022.
Other Bestselling Historical Fiction from Sourcebooks Landmark:
The Mystery of Mrs. Christie by Marie Benedict
The Engineer's Wife by Tracey Enerson Wood
Sold on a Monday by Kristina McMorris
Other Formats: Audible Audiobook , Hardcover , Paperback , Audio CD
The Book Woman's Daughter: A Novel 3 May, 2022
THE INSTANT NEW YORK TIMES BESTSELLER!
"A powerful portrait of the courageous women who fought against ignorance, misogyny, and racial prejudice." —William Kent Krueger, New York Times bestselling author of This Tender Land and Lightning Strike
The new novel from the New York Times bestselling author of The Book Woman of Troublesome Creek!
Bestselling historical fiction author Kim Michele Richardson is back with the perfect book club read following Honey Lovett, the daughter of the beloved Troublesome book woman, who must fight for her own independence with the help of the women who guide her and the books that set her free.
In the ruggedness of the beautiful Kentucky mountains, Honey Lovett has always known that the old ways can make a hard life harder. As the daughter of the famed blue-skinned, Troublesome Creek packhorse librarian, Honey and her family have been hiding from the law all her life. But when her mother and father are imprisoned, Honey realizes she must fight to stay free, or risk being sent away for good.
Picking up her mother's old packhorse library route, Honey begins to deliver books to the remote hollers of Appalachia. Honey is looking to prove that she doesn't need anyone telling her how to survive. But the route can be treacherous, and some folks aren't as keen to let a woman pave her own way.
If Honey wants to bring the freedom books provide to the families who need it most, she's going to have to fight for her place, and along the way, learn that the extraordinary women who run the hills and hollers can make all the difference in the world.
Praise for The Book Woman's Daughter:
"In Kim Michele Richardson's beautifully and authentically rendered The Book Woman's Daughter she once again paints a stunning portrait of the raw, somber beauty of Appalachia, the strong resolve of remarkable women living in a world dominated by men, and the power of books and sisterhood to prevail in the harshest circumstances. A critical and profoundly important read for our time. Badassery womanhood at its best!"—Sara Gruen, #1 New York Times bestselling author of Water for Elephants
"Fierce, beautiful and inspirational, Kim Michele Richardson has created a powerful tale about brave extraordinary heroines who are downright haunting and unforgettable."—Abbott Kahler, New York Times bestselling author (as Karen Abbott) of The Ghosts of Eden Park
The Sisters of Glass Ferry 28 Nov, 2017
"An emotionally resonant tale of secrets, regret, and absolution that held me spellbound. You simply have to read it." —Sara Gruen, #1 New York Times bestselling author of Water for Elephants
Spanning several decades and written in an authentic voice both lyrical and wise, The Sisters of Glass Ferry is a haunting novel about small-town Southern secrets, loss and atonement, and the unbreakable bond between siblings.
Glass Ferry, Kentucky, is bourbon country. Whiskey has been a way of life for generations, enabling families to provide and survive even in the darkest times. Flannery Butler's daddy, Beauregard "Honey Bee" Butler, was known for making some of the best whiskey in the state, aged in barrels he'd take by boat up and down the Kentucky River until the rocking waters turned the spirits smooth and golden. Flannery is the only person Honey Bee ever entrusted with his recipes before he passed on, swearing her to secrecy as he did so.
But Flannery is harboring other secrets too, about her twin sister Patsy, older by eight minutes and pretty in a way Flannery knows she'll never be. Then comes the prom night when Patsy—wearing a yellow chiffon dress and the family pearls—disappears along with her date. Every succeeding year on the twins' birthday, Flannery's mother bakes a strawberry cake, convinced that this is the day Patsy will finally come home. But it will be two tumultuous decades until the muddy river yields a clue about what happened that night, compelling Flannery to confront the truth about her sleepy town, her family's past, and the choices she and those closest to her have made in the name of love and retribution . . .
"Richardson has a knack for layering a landscape with secrets, for slowly revealing what's hidden until suddenly you find what you've been chasing sitting in the palm of your hand. The Sisters of Glass Ferry is bountifully written—a place fully realized and packed with characters you won't soon forget." —David Joy, author of The Weight Of This World
"The Sisters of Glass Ferry peels back the layers of a small town to reveal a labyrinth of long-buried secrets and dangerous lies. Richardson delivers a gripping, hauntingly atmospheric Southern Gothic tale that stayed with me long after I turned the last page." —Karen Abbott, New York Times bestselling author of Liar Temptress Soldier Spy
"This heart-rending, lovely family drama spans sixty years and four generations, peeling back the layers of a small town to reveal a labyrinth of long-buried lies and a wealth of dangerous secrets suspended between three families. The Sisters of Glass Ferry is so fast paced I couldn't stop turning the pages, but then I'd smash into another jewel-like sentence and have to stop to reread it. Kim Michele Richardson writes with an authentic Southern voice straight out of Kentucky, well graveled, rough with moonshine, and damn near irresistible." —Joshilyn Jackson, New York Times bestselling author of gods in Alabama and The Almost Sisters
Other Formats: Audible Audiobook , Library Binding , Paperback , MP3 CD
GodPretty in the Tobacco Field 1 May, 2016
A rural Kentucky teenager comes of age in the summer of 1969 in this novel by the New York Times–bestselling author of The Book Woman of Troublesome Creek.
Nameless, Kentucky, in 1969 is a hardscrabble community where jobs are few and poverty is a simple fact—just like the hot Appalachian breeze or the pests that can destroy a tobacco field. RubyLyn Bishop is luckier than some. Her God-fearing uncle, Gunnar, has a short fuse and high expectations, but he's given her a good home ever since she was orphaned at the age of five. Yet now a month shy of her sixteenth birthday, RubyLyn itches for more.
Maybe it's something to do with the paper fortunetellers RubyLyn has been making for townsfolk, each covered with beautifully wrought, prophetic drawings. Or perhaps it's because of Rainey Ford, her black neighbor who works alongside her in the tobacco field and with whom she has a kinship—despite the disapproval of others.
RubyLyn's predictions are just wishful thinking, not magic at all, but through them she's imagining life as it could be, away from the prejudice and hardship that ripple through Nameless…
"A voice rich and authentic, steeped in the somber beauty that defines life in the South."—David Joy, author of When These Mountains Burn
"Richardson's brilliant writing made me feel as though I were transported back in time…and actually there witnessing this poignant heartfelt story."—Charles Belfoure, New York Times–bestselling author of The Fallen Architect
"A reader always recognizes when the author has poured her soul into a body of work. [This] is a tender, beautifully written second novel."—Ann Hite, author of the Black Mountain series
Other Formats: Audible Audiobook , Paperback , Audio CD
Liar's Bench 1 May, 2015
In this coming-of-age novel, a white, small-town Kentucky teen uncovers dark secrets while investigating her mother's suspicious death in 1972.
In 1972, on Mudas Summers's seventeenth birthday, her beloved Mama, Ella, is found hanging from the rafters of their home. Most people in Peckinpaw, Kentucky, assume that Ella's no-good husband did the deed. Others think Ella grew tired of his abuse and did it herself. Muddy is determined to find out for sure either way, especially once she finds strange papers hidden amongst her mama's possessions.
But Peckinpaw keeps its secrets buried deep. Muddy's almost-more-than-friend, Bobby Marshall, knows that better than most. Though he passes for white, one of his ancestors was Frannie Crow, a slave hanged a century ago on nearby Hark Hill Plantation. Adorning the town square is a seat built from Frannie's gallows. A tribute, a relic—and a caution—it's known as Liar's Bench. Now, the answers Muddy seeks soon lead back to Hark Hill, to hatred and corruption that have echoed through the years—and lies she must be brave enough to confront at last.
"Glorious… Liar's Bench succeeds on many levels…. Much of any reader's delight will be rooted in savoring the sounds, smells, tastes, and fragrances that enhance her captivating vision of a typical Southern small town during two linked periods of its history."—Southern Literary Review
"This has southern small-town charm… includes recipes and discussion questions and may appeal to those who like Rebecca Wells or Jennifer Chiaverini."—Booklist
"A satisfying mystery with thought-provoking historical elements, written in a sassy Southern voice."—Historical Novels Review
The Unbreakable Child 18 Oct, 2012
by Kim Michele Richardson, David Clohessy, Father Thomas Doyle J.C.D. C.A.D.C.
The Unbreakable Child, a story about forgiving the unforgivable is a riveting journey inside the secretive underbelly of the St. Thomas / Saint Vincent Orphan Asylum in rural Kentucky. It is the first book in the United States to confront the institutionalized physical and emotional abuse suffered by countless orphans at the hands of Catholic clergy over these last decades. It also documents the historic United States lawsuit and first-ever settlement paid by Roman Catholic nuns in the United States as recompense for decades of brutal institutional abuse of the author, her sisters and forty-two other children.
Other Formats: Audible Audiobook , Hardcover , Paperback , MP3 CD


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Why this Kardashian-Jenner will never get her own spin-off
Site: Samantha Ledlin
If you were holding out hope for a Kendall Jenner show, we've got bad news for you
If you feel like the Kardashian-Jenner's are splashed all over your newsfeed today, well that's because they are. Kris 'momager' Jenner runs a well-oiled machine; It's no coincidence that all of these baby rumours (first Kylie, now Khloé!?) happen to come about the same week that the Keeping Up With The Kardashian's 10th anniversary season premiers. Hats off to you Kris, teach us your ways.
In news of the reality show that everyone loves to hate, Kris Jenner has revealed that unlike all her siblings, model-of-the-moment, Kendall will never get her own TV spin-off. Kim, Khloé and Kourtney have all had countless spin-offs; taking Miami, New York and the Hamptons to name only a few. Then there was Kim's Fairytale Wedding (we all know how that turned out), Khloé and Lamar and most recently the littlest member of the klan's Life of Kylie. Even Rob Kardashian (who so rarely appears on KUWTK) got some air time with Rob and Chyna.
In an interview with Variety, when asked about the possibility of a Kendall show, Kris Jenner responded bluntly, "No." Jenner stated that "Kendall is really satisfied on her role in Keeping Up With the Kardashians. With her modelling career she's so busy. If she's not walking a runway, she's shooting a campaign or traveling around the world with her fashion obligations. She's a pretty busy little girl."
To be honest, much like her younger sister's show, we can't really imagine what further entertainment a Kendall show could bring to the small screen. What we really want is a Kris Jenner spin-off detailing how she can simultaneously book lunch plans with Kathy Griffin, tip-off tabloids and lock in multi-million dollar deals, all while sipping on gin and tonic in her black and white Calabasas mansion. Now that would make good TV.
Kendall and Kylie Jenner launch new swimwear collection
17 things to know about Kylie Jenner's "pregnancy"
Things just got EVEN more interesting in the Kardashian household…

redpajama_set_name: RedPajamaCommonCrawl


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Home » Homepage Featured Story Slider »
SA elections were free, fair and credible: AU, SADC observers
Lerato Matlala Lerato Matlala
10 May 2019, 10:38 PM | SABC	| @SABCNewsOnline
Tags: Youth, SADC, Elections2019, SADecides
Image: SABC News
The African Union and SADC Observers' Mission are largely convinced that the 2019 national and provincial elections were free, fair and credible.
Though noting a few concerns they'd like addressed such as the participation of the youth in the polls; they have lauded the IEC for the peaceful elections.
The observers are due to make a formal declaration in a few weeks.
The AU election observer mission was led by Jakaya Kiwkete, former President of Tanzania. It comprised of a core team of four electoral experts and technical support staff from various African Union member states and institutions across the continent.
In his statement, the AU observer mission leader Kikwete commended the IEC for running the election in a professional manner.
Citing amongst others the opening in time of polling stations and the peaceful atmosphere in which they were conducted. He did, however, note a few issues.
The AU observer mission appealed to South Africans to continue maintaining the peace and unity shown during the elections.
Earlier the Southern African Development Community (SADC) Election Observer Mission gave the IEC a thumbs up for the manner in which the elections were carried.
It has also noted with concern the low registration and turnout of the youth at polling stations during the general elections.
Out of 26.7 million registered voters, 5.7 million were below the age of 30.
Head of the Mission and Zambian Foreign Minister Joseph Malanji addressed the media in Pretoria and offered the mission recommendations to improve voter sentiment amongst the youth.
"This requires special attention. The SEOM proposes the IEC, Human Sciences Research Council are urged to assess the possible causes of voter apathy amongst young South Africans with a view of designing and implementing voter and civic education programmes to address this apathy."
Malanji commended the adherence by IEC to the democratic values and principles envisioned in the SADC treaty.
But the SADC electoral observer mission also highlighted numerous challenges.
Meanwhile, the IEC says it's on track to release the final election results on Saturday.
Youth SADC Elections2019 SADecides
This entry was posted on 10 May 2019,02:53PM at 2:53 PM and is filed under Africa, News, Homepage Featured Story Slider. You can follow any responses to this entry through the RSS 2.0 feed. Both comments and pings are currently closed.
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The Andhra Pradesh Road Development Corporation (APRDC) is importing vehicles for making an assessment of nearly 41,000 km of Roads and Buildings Department with the financial assistance of the World Bank.
Chief Minister N. Chandrababu Naidu flagged off multi-purpose high technology network survey vehicles at his camp office here on Wednesday. Fitted with Hawkeye equipment and imported from Australia, the vehicles can collect high quality data for functional and structural evaluation of roads.
On the occasion, Mr. Chandrababu Naidu said the initiative was taken to create a quality data base of the condition of roads and the project was entrusted to Australian Road Research Board (ARRB) which did pioneering work in the area of road condition monitoring. It will get the data collected by a joint venture company over the next six months. The Hawkeye portable devices will help in road-profiling and video data collection. The equipment makes routine pavement monitoring surveys, roadside inventory and asset management and road safety assessment.
Australian Consul General to South India Sean Kelley and Andhra Pradesh Transport Minister Siddha Raghava Rao were among those present.


Homeostasis is an essential capability of all cells mediated by complex and diverse regulatory networks. Despite this complexity, many of the fundamental regulatory mechanisms used by cells have been evolutionarily conserved. It is thus somewhat surprising that the apparent physiologic significance of these mechanisms has been experimentally neglected. Here, we review 2 widely recognized regulatory mechanisms, allostery and compartmentalization, which exemplify this dissociation in our current understanding of the microbial pathogen, Mycobacterium tuberculosis.
Next Document: Integration of hydrogenase expression and hydrogen sensing in bacterial cell physiology.


Rachel Tucker has gone from a talented contestant in the reality TV show I'd Do Anything, to one of the West End's greatest actresses. Since leaving the BBC talent show in 2008 Rachel has secured top West End roles, released her debut album and is now facing her biggest challenge of all: motherhood!
I caught up with Rachel at the lovely St James Theatre to chat about her involvement in the new West End music collective, Tonic Fold, her debut album and to ask what is next for the star! In the video below you can watch my full interview with Rachel, where she reveals all about her life as a working mum and her thoughts on a Tucker vs Louise Dearman Elphaba showdown! You can also read our interview summary below to read her answers on a few crucial questions! Also, don't forget to check out our signature Lightning Round Challenge to see how Rachel got on!
Rachel – You shot to fame as an I'd Do Anything finalist, since then you have played hotly coveted West End roles such as Meat and Scaramouche in We Will Rock You AND spent three years as the Green Witch on the Block: Elphaba in Wicked! What is next for you?
Well at the moment…motherhood! I am absoloutely loving it! My son is almost 1 year old and it has been the most incredible year and experience! So that is another string to my bow! I am loving it! I am also back out there auditioning. I released my album, The Reason, last year and I have been doing little gigs for that, including here at the lovely St James… I am doing little concerts. But I am definitely getting back on the horse again!
Back on the West End Wagon!
So you are doing bits and bobs, including helping out with Tonic Fold. Tell us a bit about your involvement with the project?
I met Shane Cullinan [founder of Tonic Fold] when I was in Wicked and he asked if I would sing one of his songs. I said well let me hear the song…and wow! Jaw to floor. I was floored by this song. I said I would absolutely love to do it. I was honoured to be asked! Shane is a fabulous writer.
Your Track is called "Stones." Tell us a bit about it!
Stones! It has a really nice driving beat through it. I believe it is about Shane's past relationship. It is a big belt song something that I am okay at [laughs.] It is a very feel good song and I think it is a stand out on the album.
So let's talk about your album released in August last year. You've included your own songs and the show stopping number from Wicked, Defying Gravity. How did it feel recording such an onstage classic for your album?
Oh I loved it, it was brilliant! It is a wonderful song! I tried to do it as close to how I did it onstage as that is where I felt most empowered singing it. We waited to the end to record it, which we did almost in one take!
And did you have to green up to sing it?
Do you know what I did! Haha, no I didn't! ha! There with my broom!I'd have loved it!
As you mentioned you are now a mother to your lovely, almost one year old boy. Has he got mummy's singing voice?
He's a screamer! Ha! I have a video of him at about 10 weeks old and I am singing along to a song for an audition and he just completely tried to outshine his mum! He's got a high top C on him!
He's got the best mum in the business to train him up!
He hears me a lot!
How are you juggling it all?
My Husband and I are both freelance so when he's at home I can go out and do a bit of work and vice versa. I take him when I can and we have very great and helpful friends.
So moving back to Wicked…some people consider you to be the true Elphaba. Do you miss her?
I do miss her! Not only was it such a massive part of my life, but she is the ultimate female musical theatre character! Why you wouldn't want to play her would be beyond me. I just fell in love with the show and her and, yeah, its just the ultimate role!
And are there any other roles you'd have your eye on the West End?
Well, unfortunately Chicago is closed, but I'd love to give Roxie Hart in Chicago. Also Calamity Jane…I'd love that! Any producers out there…!
Before you played Elphaba you and Lousie Dearman did a little Wicked skit! You both then went on to star in the show together. Do you still keep in touch with her?
Yes! Lou and I are still very good friends!
Any chance of you doing a Dearman and popping back in the show as a different character? Perhaps Garlinda-ing it up?
No! I think that chapter is done. I stayed for as long as I did… I made sure I had fulfilled and done what I had wanted to do with it.
I have a suggestion: A Tucker Dearman showdown! You both need to Green up fly and see who can belt Defying Gravity the loudest!
Tuckman! Ha oh noo! I haven't sung it in a long time, she would win!
Well thanks for that! Before we move on to the Lightning Round I am going to let you channel your inner tchi etc! High five!
It is an Official Theatre tradition to grill the star we talk to in the form of "The Lightning Round." Watch the video below to check out how Rachel did under the pressure of being bombarded with quick fire questions!
I had a lovely time with Rachel, she is honestly a true delight as well as a great talent! You can check out Rachel's work on the Tonic Fold album which is out NOW! You can buy Rachel's album, The Reason, on itunes or from www.racheltucker.co.uk. Rachel will also be performing at the St James Theatre on Saturday the 8th and Sunday the 9th of February.


He then took me to dinner, where we kissed in the terrasse as the waiter literally sang to us."Such is Paris, where men, Leemore says, take a spontaneous approach to romance—her date with Nicolas was typical of her time there.American men, she said, "simply aren't romantic."That might be true. 1 dating agency and the owner of Cupid.com, burned a lot of money when it tried to expand its Be Naughty website with in France and in Germany."In Australia, you can never really be sure if you are on a date or you are just hanging out as friends," says Katrina, an Australian who spent a year in Texas."In America, you know you are going on a romantic date, because you are asked to do so in this surprisingly formal way." Another Australian, Andrew, told me that he found it hard to meet new people because of the lack of a formal dating culture.Frustrated, he Googled me and found a directory in which my email address was listed.In a message, he asked me for my number, and the rest, as they say, is history.For example, Henning Wiechers, from Leading Dating Sites, said many American online dating companies initially offered credit cards as the sole payment method in Europe, not knowing that only 25 percent of Germans own them.Local attitudes towards online dating can also be difficult to parse.
Potential partners are mainly set up through friends, and romance must be found within one's social circle."I met Nicolas at a party in Montmartre," she tells me.


A dynamic link to a BaseList2D object.
These links can easily be stored in containers and saved to disk, and are even preserved when duplicating hierarchies.
Allocates a base link. Destroy the allocated base link with Free(). Use AutoAlloc to automate the allocation and destruction based on scope.
The allocated base link, or nullptr if the allocation failed.
Destructs base links allocated with Alloc(). Use AutoAlloc to automate the allocation and destruction based on scope.
[in,out] link The base link to destruct. If the pointer is nullptr nothing happens. The pointer is assigned nullptr afterwards.
Evaluates the link in the specified document.
If instanceof is specified, nullptr is returned if the object is not of this type.
[in] instanceof Set this to a node type ID to only return the link if it is of this type.
The linked object, or nullptr if the link is broken or of the wrong type. The document owns the pointed object.
Evaluates the atom link in the specified document.
If instanceof is specified, nullptr is returned if the atom object is not of this type.
[in] instanceof Set this to a type ID to only return the link if it is of this type.
The linked atom object, or nullptr if the link is broken or of the wrong type. The document owns the pointed atom object.
Retrieves the stored link independent of a document.
Object A is inserted into document B.
GetLink(B) is called : returns A.
Object A is removed from document B.
GetLink(B) is called : returns nullptr.
ForceGetLink() is called : returns A.
ForceGetLink() is called : returns nullptr.
The linked object, or nullptr if the link is broken. The document owns the pointed object.
Retrieves the stored atom link independent of a document.
The linked atom object, or nullptr if the link is broken. The document owns the pointed atom object.
Sets the link to point to list.
[in] list The new atom goal. The caller owns the pointed atom goal.
Reads the link from a hyper file.
[in] hf The hyper file to read from. The caller owns the pointed hyper file.
true if the link was read, otherwise false.
Writes the link to a hyper file.
[in] hf The hyper file to write to. The caller owns the pointed hyper file.
true if the link was written, otherwise false.
Gets a copy of the link.
[in] trn An alias translator for the operation. Can be nullptr. The caller owns the pointed alias translator.
The cloned link. The caller owns the pointed link.
Copies the link to dst.
[in] dst The destination link. The caller owns the pointed link.
true if the link was copied, otherwise false.
Checks if the link points to an object within the cache of another object.
true if this link points to an object's cache, otherwise false.


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"How Long Can Opened Chicken Broth Stay In The Fridge "
If you Love How Long Can Opened Chicken Broth Stay In The Fridge then you are at the right place!!
How Long Can Opened Chicken Broth Stay In The Fridge is made from pet bones as well as connective cells-- normally livestock, poultry, or fish-- that have actually been steamed right into a broth as well as sluggish simmered for 10 to greater than 20 hrs with herbs, veggies, and also spices. So why is this apparently straightforward liquid something you would certainly intend to consume each day How Long Can Opened Chicken Broth Stay In The Fridge ?
Even our hunter-gatherer ancestors recognized that drinking How Long Can Opened Chicken Broth Stay In The Fridge resembled striking dietary gold, as its earliest variation go back over 2,500 years. Discarding anything edible ran out the inquiry at that time, so animal unguis, knuckles, bones, and various other connective cells never ever went to waste. Bone broth has an abundant background of being made use of in conventional Chinese medicine as a digestive restorative, blood building contractor, as well as kidney strengthener due to the high collagen content, bioavailable minerals, anti-inflammatory amino acids, and healing compounds that can only be found in bones as well as connective tissue How Long Can Opened Chicken Broth Stay In The Fridge.
Watch as star health fitness instructor, Thomas DeLauer damages down the ins and outs of what bone broth actually is. In just two minutes, he'll speak about what bone broth is and also what it can do for your digestive tract, joint, and also skin health How Long Can Opened Chicken Broth Stay In The Fridge.
Some phone call How Long Can Opened Chicken Broth Stay In The Fridge meat water. We call it liquid gold.
What makes this stuff so unique? The brief answer is collagen. Bones and also connective cells are the just true nutritional sources of kind II collagen-- a protein that's recognized for maintaining skin smooth and flexible as well as teeth and joints healthy and balanced, along with touting dozens of other health and wellness benefits.
Along with collagen, bones are additionally filled with several anti-inflammatory amino acids, minerals, as well as substances that can help quicken your body's natural healing procedures from points like sports injuries, joint inflammation, or leaking digestive tract.
So, these "scraps" that a lot of us typically throw in the rubbish are significant dietary giants. Yet when was the last time you devoured on an item of cow's knuckle? Or snacked on an ox tail? We'll presume the response is never.
Since we do not consume bones in their whole type, cooking them right into a broth that's simmered for 10 to 20 hours (or even more) is the very best means to release their powerful nutrients, and also experience a whole brand-new level of health.
DEMAND A FAST DESCRIPTION ON WHAT EXACTLY IS HOW LONG CAN OPENED CHICKEN BROTH STAY IN THE FRIDGE ?
Watch as Celebrity Health And Wellness Fitness Instructor, Thomas DeLauer breaks down the ins and outs of what bone broth really is. In simply two minutes, he'll talk about what bone broth is and also what it can do for your digestive tract, joint, and skin health and wellness how long can opened chicken broth stay in the fridge.
Bone broth has a rich background of being utilized as a digestive system tonic, specifically in standard Chinese medication some 2,500 years ago. Today, it is just one of the leading advised foods for boosting signs and symptoms of persistent gastrointestinal conditions, such as Cranky Digestive Tract Disorder (IBS), Crohn's illness, and also colitis.
The factor for why bone broth is so recovery for the intestine returns to collagen, which forms gelatin when it's cooked down also better. Collagen and also gelatin are not just rich in amino acids that decrease inflammation in the GI tract-- such as glutamine-- they likewise have the one-of-a-kind capability to "seal as well as recover" openings in the intestine cellular lining, which can create a problem called leaking digestive tract syndrome.
Although study remains in the beginning, there's proof to reveal that leaky intestine is the main underlying cause of digestive system problems. It's likewise a contributor to autoimmune diseases, clinical depression, brain haze, stress and anxiety, allergies, eczema, acne, and persistent reduced energy. Worst of all, leaky intestine can be silent and reveal no symptoms in the beginning. It's additionally believed to influence over 70% of the populace.
Bone broth is suggested on special intestine recovery diet plans and methods, like the GAPS diet plan, the SCD diet plan, as well as the Reduced FODMAP diet.
Whether it's an injury, arthritis, or sore muscular tissues, there's no far better means to nourish your bones and joints than by eating more of the nutrients currently located within them, consisting of hyaluronic acid, glucosamine, chondroitin, calcium, and also magnesium. Bone broth is loaded with all of these nutrients, plus a number of amino acids that help in reducing joint discomfort and inflammation, like glycine and proline. It's for these reasons that bone broth is coming to be a best recovery beverage among athletes.
A fun fact: Kettle and Fire Bone Broth was born due to the fact that our co-founder, Nick, tore his ACL playing football as well as needed a high-grade bone broth to aid speed up his recovery time. (You can find out more on that below.).
Adhering to a bone broth diet plan is wonderful for sustainable weight management. A bone broth diet plan involves consuming Paleo for 5 days as well as fasting for two. During this timespan you'll consume bone broth regularly with an increase in usage on the fasting days.
The mix of recurring fasting and also bone broth speeds up weight reduction through burning fat much more efficiently as well as limiting calorie consumption. When doing the diet, we additionally saw a reduction in cellulite.
Fat-Burning Bone Broth Alcoholic Drink How Long Can Opened Chicken Broth Stay In The Fridge.
With just a couple of ingredients, this recipe is perfect for a scrumptious as well as exceptionally easy fat-burning mixed drink that you can work up in a flash on busy early mornings prior to job or at nights post-workout.
Even if you had actually never come across bone broth before, you have actually probably heard of collagen, many thanks to the elegance sector.
Several anti-aging skin care lines include collagen to their face creams, moisturizers, as well as serums (and offer them for a king's ransom). Yet what lots of people don't know is that collagen molecules are too huge to be soaked up through the skin, which implies these lotions can not supply much in the means of results.
The bright side is that collagen can be absorbed via your digestive system. And due to the fact that there's a direct link between the intestine and also the skin, including bone broth to your diet regimen is going to have an even more powerful as well as lasting impact on the general appearance and health and wellness of your skin.
Allow's not forget hair and also nails, which are comprised of healthy proteins like collagen. Collagen helps strengthen nails, as well as urges hair to expand in thicker, quicker, as well as handle a healthy and balanced sparkle. (Remember this for the following time you obtain a negative haircut!).
Deep, restful rest is something we could all use a little even more of. In fact, statistics reveal the average person obtains less than 7 hours of rest per night, so it is essential to do every little thing you can to make those hours matter.
Bone broth is abundant in glycine, an anti-inflammatory amino acid that works on the Central Nerves (CNS). When taken before bed as a supplement, studies reveal glycine can improve rest top quality and decrease daytime sleepiness. It's a lot more effective when coupled with various other sleep-supportive nutrients, like calcium and also magnesium.
Every one of the advantages you enjoy from bone broth, your growing baby will experience, as well-- consisting of healthy and balanced bones, joints, and also a solid digestion system.
When early morning sickness hits, it can be difficult to keep nourishing food down. Yet bone broth tends to be comforting for queasiness, and also is typically well tolerated. Best of all, bone broth uses numerous of the nutrients you as well as your growing baby demand, consisting of protein, as well as essential nutrients. As an added bonus offer, the slow-moving simmer time of the bones makes the nutrients in bone broth extremely bioavailable and simpler to soak up than a nutritional supplement.
Bone broth can additionally assist boost fertility, help you have an extra comfortable maternity by nourishing rigid or agonizing joints, and also might raise calcium levels in bust milk.
Bone broth is an excellent resource of nutrition on the Paleo diet, and is urged to consume alcohol during periods of intermittent fasting. It additionally suits well with macronutrient requirements on the keto diet, and also might help in reducing signs of the keto flu.
" Not only can bone broth assist you stay clear of keto flu, but it's also packed with minerals that heal leaky gut and also reduce swelling in your intestines." - Leanne Vogel, Writer of The Keto Diet.
The nourishment as well as recovery potential of bone broth is so powerful, that a whole diet plan-- The Bone Broth Diet-- has actually been produced around it.
The nutrients in bone broth make it an effective practical food that can profit your whole family members-- including your hair children. Bone broth benefits your pet's shiny layer, bones, joints, digestion, and also teeth.
Right here you can discover just how Nellie, a 15 year old rescue puppy, beat her probabilities of living by only consuming alcohol bone broth.
Loaded with protein - Poultry is a great protein source and exact same goes for chicken bones. Pot & Fire bone broth comes packed with 10 grams of healthy protein per offering How Long Can Opened Chicken Broth Stay In The Fridge.
Decreases digestive tract inflammation - Bone broth assists heal as well as secure a dripping gut which is the source for lots of autoimmune illness.
Rich in bone marrow - Bone broth made from 100% lawn fed livestock and simmered over lengthy cook times removes bone marrow which contains healthy nourishing hormonal agents and lipids.
Filled with amino acids - Similar to poultry bone broth, the nutrients drawn out from beef bones have amino acids like glycine and glutamine that improves digestion as well as repair services your intestine cellular lining.
No. Plants are an excellent source of minerals and vitamins that can aid boost your body to create its very own collagen, but there is no recognized plant food that provides type II collagen, the type that offers all of the health advantages listed above.
One point to consider concerning bone broth that sets it aside from plant foods: Even if you do eat a variety of plants that are rich in collagen-boosting nutrients, if you have a weakened gastrointestinal system or dripping gut, you may not fully absorb them. On the various other hand, the collagen in bone broth is extremely easy to absorb, also for those with jeopardized digestive system systems.
Naturally, you don't just need to drink it-- although we do have a totally free and epic downloadable bone broth sipping guide for when you do. You can mix bone broth right into your environment-friendly smoothie mixes, make healthy collagen gummy bears, and use it in everything from clambered eggs, soups, curries, stews, morning meal bowls, and also tacos.
Bone broth is an all-in-one superfood, packed with nutrients that give energy and also inspiration, aid you rest better, make your skin look smoother, and also can help recover digestive system issues like leaky digestive tract.
Bones and connective tissue are storehouses for necessary amino acids as well as minerals-- which are lacking in lots of diet regimens today. Bone Broth is also an indispensable source of protein, collagen and gelatin.
It's not viable to consume whole bones or tissue, however you can still delight in these wellness benefits by drinking bone broth. Collagen is removed when you simmer bones for an extended period of time. Typically, the longer bone broth simmers, the more collagen you'll remove.
Making bone broth is a straightforward procedure, yet one that requires plenty of time as well as patience. If time is out your side we can aid you out with that said.
Bone broth is made by simmering animal bones and also tissue for at the very least 10 hrs with vegetables, herbs, as well as spices such as thyme, garlic, as well as bay leaves. Premium bone broth begins with high-grade components, using bones from organic grass-fed animals as well as natural veggies. While any type of bone or tendon can be made use of, knuckles, poultry feet, and thigh bones tend to include one of the most collagen.
Simmering bones for a prolonged period of time is what provides bone broth its health advantages, drawing out the amino acids, minerals, as well as collagen. This is a Pot & Fire-tested slow stove poultry bone broth recipe that features organic poultry bones, sea salt, fresh veggies like celery stalks, onions, and also bell peppers, and also herbs like parsley, rosemary, as well as thyme.
Simply cooking bones (no meat) as well as water is mosting likely to be mostly tasteless. Food preparation the blend for hrs at a time isn't mosting likely to make it taste any kind of better.
The idea that you're getting tons of nutrients from the bones is a MYTH that won't pass away, although it has actually been unmasked countless times, including through laboratory tests. The notion that adding vinegar to "launch" those nutrients has actually likewise been exposed. You simply end up with a watery mess that tastes of vinegar.
Instead, get bones with meat on them. After that include veggies such as onions, carrots, celery, as well as simply enough water to cover everything (generally 8 or 10 mugs). Skip the vinegar! Simmer for 3 to 4 hours for hen, a little longer for beef. Season according to choice. If you have an Immediate Pot, 25 to 35 minutes has to do with right.
What you will certainly obtain with this technique is a really delicious broth that's most likely substantially extra nourishing-- including lots of collagen-- and more healthful than any kind of bone broth, as well as it will certainly taste one heck of a great deal much better. You can either consume the meat and veggies (it's called SOUP) or you can stress them out as well as simply drink the broth if you favor.
Inspect Ina Garten's dish for chicken broth. It's very comparable to this one and has actually been used with small variations by educated chefs for years.
Regular broth and also stock are simmered for a much shorter time period than bone broth, roughly 2-- 6 hrs. The expedited cooking procedure reduces the quantity of valuable jelly drawn out from the bones, decreasing its capability to enhance the body immune system, heal digestion problems, and lower the signs of leaky intestine.
Prior To Kettle and Fire was born, one of our founders, Nick, tore his ACL playing soccer (ouch). His sibling Justin found out about the advantages of bone broth for injury recovery. As his schedule didn't leave much time to make bone broth from the ground up, he laid out to acquire a store-bought, high-grade, grass-fed bone broth, given that both of their busy timetables didn't leave much time to make the broth themselves. (You can learn more regarding our story here.).
Despite exactly how hard Justin looked, the ideal bone broth didn't exist. He searched for one that was one hundred percent natural, fresh-- never iced up-- grass-fed, as well as slow-moving simmered (in addition to one that could be shipped without wasteful, cumbersome packaging). So, Nick and also Justin decided to create a high-quality bone broth on their terms, which is the dish we're pleased to provide you today.
" Pot & Fire gives a beneficial, high quality bone broth in a tasty and convenient shelf-stable style. I enjoy always understanding that I have actually obtained wonderful broth available, without congesting my freezer or requiring defrosting." - Dr. Sarah Ballantyne, three-time NYT Best-Selling Writer.
The attractive feature of bone broth is that there's really no limitation to just how you can add it to your diet regimen. Apart from soups, stews, and also plain ol' drinking, bone broth mixes surprisingly well into almost any type of recipe-- even healthy smoothies! Below are our top means to get it:.
Our bone broth tastes scrumptious sufficient to sip by itself, yet you can spice it approximately match your palate. We created our favored flavor combinations in this complimentary downloadable "Bone Broth Sipping Overview" (bone broth matcha cappucinos, anybody?). Get your free duplicate right here.
Consuming alcohol bone broth doesn't have to be dull-- there are limitless methods to spice it and drink it. Get immediate access to over 15 of our favored bone broth sipping combinations, including ginger and also turmeric bone broth restorative and also chili, and cardamom bone broth potion. Find out how to use bone broth in your matcha cappucinos, golden milk, and also exotic fruit shakes.
Our beef bone broth has a moderate flavor, which allows it to mix quickly with practically anything, from healthy smoothies to healthy and balanced gummy bears. Our poultry bone broth as well as mushroom hen bone broth increase the savory taste of soups, stews, and risotto recipes. A few of our favorites consist of:.
The Bone Broth Diet not only enhances your consumption of the healing nutrients as well as substances crucial for digestive tract, skin, joint, and bone health, however helps deal with systemic swelling, which is at the source of a lot of Western illnesses and also conditions.
The bone broth diet regimen is a 21-day strategy that's excellent for any individual struggling with a chronic wellness condition (such as an autoimmune disorder), or anybody who wishes to reset their digestive system and also experience radiant health. Find out more concerning the 21-day bone broth diet regimen right here.


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text:
Q: javascript indexOf/replace multiple search terms Let's say I have the following text:
var text = "aaa bbb eee ccc
ddd eee fff ggg hhh iii jjj kkk";

the search term is:
var search = "eee ggg";

I want to know one of the following ( equivalent ) :
a) either know through (preferrably) a regex the position (indexOf) in the text where the search term was found. In this case indexOf() should return 20. ( Notice that there is one more single eee before the one in eee fff ggg*
OR
b) be able to .replace the found term eee fff ggg to newinsertedstring eee fff ggg
thanks in advance
edit there are some br in the text variable which split the lines, so it should only find it/replace it in the line which has all search terms.

A: I think this will do it:
var text = "aaa bbb eee ccc
ddd eee fff ggg hhh iii jjj kkk";
var search = /eee [^e<>]*ggg/g;

console.log(text.search(search)); // a)
console.log(text.replace(search, "newinsertedstring $&")); // b)

A:
i want to find the line where the pattern which contains eee AND ggg is

That's a different question, but OK.
var text = "aaa bbb eee ccc
ddd eee fff ggg hhh iii jjj kkk",
    search = "eee ggg";

var lines = text.split("
"),
    terms = search.split(" "),
    firstOccurence = new RegExp(terms.join("|"));
function containedIn(l){
    return function(t) { return l.indexOf(t) > -1; }
}

for (var i=0; i<lines.length; i++)
    if (terms.every(containedIn(lines[i]))
        lines[i] = lines[i].replace(firstOccurence, "newinsertedString $&");
var result = lines.join("
");

A: var text = "whatever".Replace("eee fff ggg", "newinsertedstring eee fff ggg");

redpajama_set_name: RedPajamaStackExchange


Coming with our next major patch, Heroes of the Storm is launching a brand new system to celebrate and recognize incredible personal feats on the battleground. Play your heart out in every match and earn your place as MVP!
At the end of every match, excluding Custom matches, the game will automatically promote a player to MVP based on their performance in the match. All players will be eligible for the title of MVP and Awards, regardless of whether or not they were on the winning team, so be sure to try your hardest in every match to earn your place on the Award screen.
Of course, the MVP isn't alone in performing heroic feats of strength on the battlefield. Awards will also be distributed at the end of the match to four other players who made significant unique individual contributions to their team. Just like the MVP, your skill will earn you a place on the Award screen, allowing others to commend your achievement, as well as a unique icon next to your name on the end-of-match Stats screen. Take a look at a few examples of some of the awards you could earn below.
Instead of leaving it up to the game to completely decide who had the greatest or most impressive individual impact, we're allowing everyone in the game to pick an awarded player to commend at the end of every match. Commendations serve as a virtual thumbs-up, recognizing the player that you thought earned some additional attention. By simply clicking the arrow underneath that player's Award, you can boost them up and support their accomplishments for everyone to see. Allied chat will also be available for the duration of the Awards celebration, which should take about 15 seconds in total, so dish out commendations and say your congrats to any teammates who you feel deserved some praise! Players who receive enough commendations at the end of the match will be elevated to Epic or Legendary status and may even receive a little extra fanfare.
We hope you've enjoyed this preview of the upcoming MVP and Awards system. Good luck out there, Heroes, we're sure we'll be seeing you on the Award screen soon!


text:
Study Finds Toxins From Coal Strip Mines
[imgbelt img=BuilderLevy.gif]
The U.S. Geological Survey finds that people living in the southern West Virginia coalfields live with significantly higher levels of toxins in the air and water than residents in the rest of the state.
EnergyHealth
By Alice Su On Jul 24, 2012 Last updated Jul 24, 2012
The face of mountaintop removal. Brushy Fork Impoundment, Marfork Coal Co., a subsidiary of Massey Energy Corp., in Raleigh County, West Virginia
put an item on their website criticizing the papers for failing to account for "one of the most prominent sources of birth defects" — inbreeding. Crowell & Moring later removed the memo and issued an apology, but not before Appalachian media noted the firm's ties to the National Mining Association and coal giants like Massey Energy, now owned by Alpha Natural Resources.
"Their first response was to say that West Virginians can't refrain from committing incest," said Kincaid. "That's what we've come to expect from the coal industries. They absolutely refuse to deal with the reality of what they're doing."
"The alert highlighted six scientific factors that the [WVU] study of birth defects in mountaintop mining communities failed to adequately address," Nicole Quigley, Crowell & Moring's public relations director, said in a statement at the time. "We did not intend to offend, and apologize for any offense taken."
Coal mining is not "per se an independent risk factor for increased mortality in Appalachia," concludes Dr. Jonathan Borak, professor of epidemiology and medicine at Yale University, in a paper funded by the National Mining Association. Borak said poor health in Appalachia was caused by "a very marked cultural problem" characteristic of low-income coal-mining communities.
"Not that these people are inherently defective or stupid or anything else," Borak said in a phone interview. "They're just in very unsupportive environments."
Borak said the coal mining industry "creates a culture" that contributes to a society with low income, little health insurance, less education, high unemployment, heavy smoking and obesity.
Asked why his paper was funded by the mining group rather than Yale, Borak said he would have had to undergo a "very complicated grant application process" otherwise. "Yale doesn't pay salary to do what you want to do," Borak said. "I had to pay the rent."
Carol Raulston, senior vice president of communications at the National Mining Association, sees no "direct connection" between coal mining and sickness.
"People with lower incomes have poor health care. They have poor diets. They have a lot of issues that continue to cause bad health," Raulston said. "You have very similar health outcomes in Detroit. But no one's talking about putting a moratorium on automobile production. A lot of it is related to poverty."
Coal cult control
Webb, the activist, said central Appalachia does suffer from a cultural problem — acquiescence to the coal industry. "West Virginia is not a democracy," Webb said. "Everyone is beholden to, owned by, bows down to the coal industry."
Activists have asked Congress to place a moratorium on mountaintop-removal permitting until comprehensive health studies are completed. The Appalachian Communities Health Emergency Act, sponsored by 15 House members, is supported by environmental groups Earthjustice, the Sierra Club, West Virginia Highlands Conservancy, the Ohio Valley Environmental Coalition and Southern Appalachian Mountain Stewards.
Bill co-sponsor Rep. Louise Slaughter, D-N.Y., originally from Harlan County, Ky., dismissed the coal industry's attempts to invalidate the work of Hendryx and other researchers.
"I'm a microbiologist. I have a master's degree in public health," Slaughter said. "I don't believe it."
Yet Slaughter said there was "zero" chance the bill could pass in the Republican-controlled House, especially with the Appalachian representatives' pro-industry leanings. "There's no question that the mining interests really own the place," Slaughter said. "I don't see sudden reversal of that."
According to the Center for Responsive Politics, the top recipient of campaign contributions from the mining industry in both the 2010 and 2012 election cycles is Sen. Joe Manchin (D-W.Va.), who received $298,098 for 2010 and more than $275,000 so far for 2012. In the House, Rep. David McKinley (R-W.Va.) is the top recipient with more than $280,000 in this election cycle so far.
Manchin and McKinley did not respond to interview requests Thursday from the Center for Public Integrity.
Sick and stuck
Asked how legislators might be convinced to halt mountaintop mining, Slaughter said that "elections matter."
But Webb said most of his neighbors were reluctant to speak against the coal companies. "They're told, 'If you step up and your nephew, cousin or son works for the coal company, they'll get fired,' '' he said. "They just ramp up the heat on the citizens, and they clam up."
Webb, a Vietnam War veteran and sixth-generation native of West Virginia's Coal River Valley, comes from a family of miners. When he began fighting against mountaintop removal, Webb said, he became "hated" by neighbors and cousins who thought he was threatening their jobs. He said some locals tried to run him over with a car in 2005.
"They just don't want to believe it. They think mountains are forever and coal is forever," Webb said. "They refuse to look at the data."
Coal River Mountain Watch spearheaded a renewable energy campaign in 2009, proposing a wind farm as an alternative to mining on Coal River Mountain. Webb said the project showed that wind farms could bring in over $1.2 million of sustainable revenue to the valley annually. In contrast, he said, mountaintop mining would produce an estimated $32,000 a year for a maximum of 11 years, after which there would be no coal left. The project failed.
Three mountaintop removal permits have already been approved on Coal River Mountain.
"The county commissioners actually cried with tears and said, 'The coal industry has been so good to us,' " Webb said. "But the coal company is going to take their jobs. They're down to the last piece of coal. They're going to walk out and our people are going to be left with nothing but sickness."
Holly Clark, another supporter of the reform campaign, became concerned over coal mining's impact on her community's health. "I'm sitting in church listening week after week about all the cancer and tumors," said Clark, from Fayetteville, W.Va. "I just wanted to do something."
Other residents of Appalachia seem unlikely to push for change — unless the health risks become undeniable. Activists hope the USGS data will have that effect.
"We don't see this as a Democratic or Republican issue. We see this as a human rights issue," Kincaid said. "Appalachia cannot afford to wait. We've been sacrificed for far too long."
Alice Su is a reporter with the Center for Public Integrity. This article is reprinted from the Center with permission.
BioFuels and EnergyBy Alice SuHealthMust-Read
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Get ready to Snap, Style, and Share with the new #SNAPSTAR dolls, from YULU!
We were recently sent two #SNAPSTAR fashion dolls and accessory packs and let me tell ya, I had one excited 6-year-old little girl. She spotted them at Walmart recently and told me to put them on her wish list because "they look super fashionable, mom" and well, I couldn't argue that.
Lola, Aspen, Dawn, Yuki, Echo and Izzy make up the #SNAPSTAR squad. Each doll has its own distinct personality and style, but do you want to know what really makes this squad completely unique? #SNAPSTAR dolls are fully articulated and poseable beyond almost any other fashion doll on the market!
Combine that with the unique #SNAPSTAR stand and green screen and you can create TONS of poses and pics, without seeing the stand! While my 6-year-old is a bit young to be turning her doll into a social media star she does enjoy dressing them up and taking pictures.
I've also been helping her changing their style with dozens of customizable options for hair, makeup, accessories and all kinds of things in the free #SNAPSTAR Studio App. The app is great for tweens who will love posing their #SNAPSTAR dolls, snapping pics of their styles, and sharing them on social media using #SNAPSTAR.
You can find #SNAPSTAR dolls exclusively at Walmart and the app is available in the App Store or on Google Play.


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              <outputDirectory>${project.build.directory}/jars</outputDirectory>
            </configuration>
          </execution>
        </executions>
      </plugin>
      <plugin>
        <!-- enable tycho to support eclipse type artifacts -->
        <groupId>org.eclipse.tycho</groupId>
        <artifactId>tycho-maven-plugin</artifactId>
        <extensions>true</extensions>
      </plugin>
      <plugin>
        <!-- configuration to be able to use maven bundle as osgi bundles -->
        <groupId>org.eclipse.tycho</groupId>
        <artifactId>target-platform-configuration</artifactId>
        <configuration>
          <resolver>p2</resolver>
          <pomDependencies>consider</pomDependencies>
        </configuration>
      </plugin>
    </plugins>
  </build>
</project>

redpajama_set_name: RedPajamaGithub


text:
By Philip Mantione
Sound synthesis has been around for well over a hundred years. "The Telharmonium (also known as the Dynamophone) […] was developed by Thaddeus Cahill circa 1896." (source). The basic premise was additive synthesis, and the device used tonewheels, as did the Hammond organ. These electromagnetic and electromechanical strategies provided the basis for the proliferation of innovative electronic instruments and designs in the second half of the 20th Century.
The telharmonium
In 1928, Maurice Martenot invented the Ondes Martenot which was played by with a metal ring worn on the right index finger. The ring was slid along a wire to produce pitched electronic tones. Later versions had a non-functioning keyboard which gave the player a visual indication of pitch based on their position on the wire. In the later versions a functioning keyboard was introduced along with other features which were to become standard in modern synthesizers such as touch sensitivity, vibrato and the use of multiple waveforms. This instrument was used in several landmark compositions, most notably in Olivier Messiaen's Turangalîla-Symphonie. It's an absolute masterpiece you should hear performed live if you ever get a chance.
Probably the most recognizable electronic sound of the 20th Century is the Theremin, invented by Leo Theremin also in 1928. The spooky electronic vibrato sound became an iconic fixture in horror and suspense film scores and is still a favorite among contemporary composers.
What remains magical about this instrument is that it does not require physical contact to be played. Instead, the performer uses one hand to control the frequency and the other to control amplitude via proximity to two antennas. In the hands of virtuosic performers such as Lydia Kavina, the Theremin is capable of expressive and precisely pitched string-like lines. Robert Moog was known to be fascinated by the Theremin and built his own at the age of 14 from plans in Electronics World magazine.
The modern-day Vocoder owes its existence to early developments and research at Bell Labs, where Homer Dudley invented the technology. Initially intended to reduce the bandwidth of a signal so it could travel long distances, the robotic sound was popularized by Kraftwerk, the iconic German band that were pioneers of early electronic music.
This article will provide an overview of current synthesis models now in use with several links along the way to articles that take a deeper dive into each method. It will include a list and description of common parameters, control methods and a discussion of hardware versus software. But since we are talking about electricity and sound, let's start with signal flow.
Typical Sections and Signal Flow
In all cases, there is some sort of user input that initiates the signal in a system. Even in the extreme case of algorithmic or AI based models, someone needs to program the underlying architecture and hit the start button. But as we are talking about instruments, consider the various ways a musician can instigate a sound.
There are myriad controllers available that can be connected to synthesizer modules or a computer. Typically MIDI (although not always), they include: keyboards, MIDI guitars, breath controllers, knob and slider devices, iOS apps and all sorts of alternative controllers.
Check the articles below for more about controllers.
"8 Unusual MIDI Controllers for Music Production"
Sound Generation
Following some sort of user input is the sound generation section. The nature of this section is dependent on the method of synthesis being used and could be comprised of oscillators, noise generators, recorded samples, wavetables, sound-generating algorithms or any combination.
After some sound is generated it is often sent to a filtering section where frequencies can be sculpted using the full complement of filter types, although the low-pass filter is the most commonly used.
The last of the three major sections in the signal flow is where the signal gets amplified and shaped before being sent to the output. This section will typically include an envelope that is triggered by the input of the user and will have generally four basic stages: attack, decay, sustain and release (ADSR) — more on this later.
This section is not inserted in the signal flow per se. Instead, it includes data-generating tools to alter the parameters in other sections and sometimes even parameters of the modulators themselves. These modulators can include LFOs (low frequency oscillators), envelopes, step sequencers, etc.
Effects Section
Modern synthesizers (especially soft synths) have onboard effects sections that can include distortion, saturation, chorus, flange, reverb, delay, panning and EQ. These are usually inserted before or after filtering depending on the device. More elaborate synths often have send/return capability and more sophisticated routing possibilities.
Not all synths have all these sections and some have sections unique to the method being used (e.g. granular or component modeling synths). But if you can get a firm grasp of the basic signal flow outlined above, you will be much better prepared to understand just about any synth you might come across.
The Methods
As mentioned, additive synthesis is one of the oldest types out there. One challenge for using this method is that you need many more oscillators to produce rich timbres when compared to other methods. This was a particular problem when computing was in its nascency. As described by Curtis Roads, "additive synthesis is a class of sound synthesis techniques based on the summation of elementary waveforms to create a more complex waveform." (Roads, 2012, p. 134)
For more on this method check out: "The Basics of Additive Synthesis"
Subtractive Synthesis
This method is generally comprised of the main sections mentioned above and uses the filtering section particularly to generate rich timbres and variety. It requires far fewer resources than an additive model — only a rich sound source like a sawtooth wave or noise generator and a robust filtering section.
More on subtractive synthesis: "The Fundamentals of Subtractive Synthesis"
Frequency modulation synthesis is based on the idea of using one oscillator (the modulator) to modulate another oscillator (the carrier). From this essential idea, an incredible amount of timbral variety can be produced. The introduction of the revolutionary DX7 by Yamaha in the early 80s blew the lid off the possibilities of digital synthesis given the limitations of computing power at the time.
More on FM synthesis here: "Introduction to FM Synthesis"
AM Synthesis
Amplitude modulation (AM) is more of an effect than a primary means of synthesis. It also uses modulator and carrier oscillators to produce an effect known as ring modulation where the amplitudes of a waveform periodically dip to zero causing additional frequencies to be created. By changing the depth and DC offset of an amplitude modulated signal, AM can produce a variety of tremolo based sounds at low modulator frequencies and audible sideband frequencies and higher modulation rates.
More in this article: "The Fundamentals of AM Synthesis"
Phase Distortion Synthesis
This method was used by Casio in the CZ-101 and some other models introduced back in the early 80s. It holds a special place in my heart as my first synth. It uses an interesting and unique idea that involves scanning "through a basic sine wave lookup table at an increasing and then decreasing speed while keeping the overall frequency constant as it relates to the pitch or note".
More on this method here: "The Fundamentals of Phase Distortion Synthesis"
Vector Synthesis
This method uses the idea of mixing the output of two or more sound sources. These are typically oscillators although there are several sampling instruments that use a similar approach: blending combinations of sampled sounds using some sort of XY pad interface. In its simplest form, you can consider combining more than two oscillators a form of vector synthesis, but typically there are more, and often oscillators can be detuned in relation to each other. Many subtractive synth models use a vector approach to instigate a rich sound source as input for the filtering section.
Wavetable Synthesis
Wavetable synthesis involves reading through a lookup table which can include anywhere from a single cycle waveform to dozens or hundreds. The process of reading through these forms and morphing between shapes can be modulated and controlled by the user. "The interpolation between wave shapes is what creates the characteristic sound of a wavetable synth."
More here: "The Basics of Wavetable Synthesis"
Component or Physical Modeling
This method can be computationally high compared to other models and includes using complex algorithms. Often the metaphor of a vibrating string is used to create unusual and often unworldly timbres that are perfect for sound design applications. I am also a fan of the percussive mallet-like sounds possible with this method that seem to lie somewhere between the acoustic and electronic worlds.
More on the subject here: "The Fundamentals of Physical Modeling Synthesis"
Granular Synthesis
This is another method that was once considered impractical in terms of real time applications due to computer requirements. Those days are long gone, and real time granular synthesis is now completely possible on any computer, tablet or smartphone. The essential idea is to take a recorded sample and chop it up into small pieces or grains, anywhere from 1 to 100ms in duration. These grains can then be operated on independently by pitch shifting, reversing, reordering and other methods.
More about this here: "Overview of Granular Synthesis"
Although not strictly speaking a form of synthesis, samplers need to be included here because many of the techniques found in synthesizers can also be found in samplers including filtering, effects processing, modulation methods and vector style morphing as mentioned earlier. Pure samplers use recorded sounds as the main sound source(s). There can be hundreds of samples in one instrument, as is often the case with so-called deep-sampled instruments. An example is an acoustic sample library like a piano, where every key might be sampled independently at a variety of dynamic levels or with different pedal techniques. This painstaking process is why some orchestral libraries are so expensive.
More on samplers here: "The Fundamentals of Sampling Instruments and Libraries"
Hybrid Instruments
Several of the methods discussed above might be found within one single device as more and more hybrid instruments continue to emerge. Sometimes being a jack of all trades is indeed possible in the synthesis world. But specialization has its benefits, so if you want a great granular synthesizer, for instance, look for something billed as such.
Common Modulation Methods
The Humble LFO
I would say that about 90% of my beginning students can identify an LFO as a low frequency oscillator. But only about 25% can tell me what that means or how it's used. These simple oscillators churn out periodic data based on a chosen waveform shape at rates typically well below the audio rate of 20 Hz. They can be extremely slow like 0.1 Hz or slower. They can be used to modulate any parameter in the device as long as the instrument allows the signal path.
More here: "5 Essential LFO Parameters You Should Know"
The typical ADSR (attack, decay, sustain and release) envelope that most people can identify is usually attached or hardwired to amplitude. But envelopes can be used to modulate any parameter that LFOs can. The difference is that envelopes are often tied to user input. For example, as a MIDI note-on event is triggered, an envelope might also be triggered that is tied to the cutoff frequency of a low-pass filter. Think of envelopes as a table of data that is released over a user-defined amount of time. This is often triggered by the pressing and releasing of a MIDI key.
More on this subject here: "The Basics of Synth Envelope Parameters, Functions and Uses"
Step Sequencers
Step sequencers send out user specified data for every step which can be used to modulate synth parameters. These devices are usually synced to the tempo of the session if they are in a DAW, or they can be synced internally or externally by means of a clock or sync signal. While it is true that drum machines are clearly step sequencers, do not limit yourself by only thinking in these terms. These devices are superpowerful modulation sources that should be explored in depth.
Here's an article to get you started: "The Basics of Step Sequencing (+ 9 Great Step Sequencers)"
Other Modulation Sources
There are many unique and fantastic modulation ideas to be found in the wide array of synths on the market. Developers have used all sorts of creative approaches that defy categorization.
Here is an article that explores some of these approaches: "A Guide to Synth Modulation Sources and Controls"
Less Understood Parameters
There are some synth parameters that seem harder to wrap your head around than others such as key follow, octaves expressed in feet and others. Even the difference between legato and mono settings can elude newcomers.
Read this article for a look at some less talked about parameters: "18 Synth Parameters That Are Often Misunderstood"
Check out my other articles, reviews, interviews, and my video tutorial series, Synthesis 101 available exclusively on The Pro Audio Files.
Follow me on Twitter: @PMantione
Instagram: philipmantione
Roads, Curtis. The Computer Music Tutorial. MIT Press, 2012.
Philip Mantione
Philip Mantione is a composer, synthesist, guitarist, educator and sound artist active in the LA experimental music scene. His music has been presented in festivals, museums and galleries worldwide. His current project is TriAngular Bent, an electroacoustic trio featuring Don Preston (founding member of Frank Zappa's Mothers of Invention) and circuit bending virtuoso, Jeff Boynton. Details at philipmantione.com
The Fundamentals of Phase Distortion Synthesis
Introduction to FM Synthesis
The Basics of Additive Synthesis
New Course: Synthesis 101
The Basics of Compressor Sidechain and Detection
iZotope VocalSynth: Basic Processing Effects (Part 3)
Train Your Ears
Improve your EQ skills in as little as two weeks


text:
Primary Care Helena Duque-Pages, MD
Marcus Bolton, APRN-CNP
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La SENP5 (Sentrin-specific protease 5 o també anomenada Q96HI0) és un enzim, concretament una proteasa. Pertany a una família de cisteïna proteases característiques dels Homo sapiens anomenades SUMO-specific proteases (o isopeptidases SUMO).  Aquesta família es divideix en tres subgrups diferents: la família Ulp/SENP (ubiquitin-like protease/sentrin-specific protease), la família Desi (deSUMOylating isopeptidase) i la família USPL1 (ubiquitin-specific peptidase-like protein 1).

L'activitat de les SENP es basa a catalitzar a les SUMO (proteïnes encarregades de modificar covalentment a altres proteïnes en el procés post-traduccional). La SENP5 s'encarrega concretament de catalizar la maduració de la SUMO3 i la desconjugació de la SUMO 2 (procés anomenat deSUMOylation), produint un tall en l'extrem C-terminal, el que produeix pèptids o aminoàcids lliures. Cal destacar també que és un enzim que pren un paper molt important en la divisió cel·lular, especialment en la citocinesi i en la mitosi.

Estructura i composició
Està formada per 755 aminoàcids (aa).  La seva estructura i composició és molt similar a la SENP3: comparteixen una seqüència i un substrat molt semblant. També és similar al domini catalític de les Ulp tenint entre un 20 a un 60% de semblança.

En l'extrem N-terminal és on es situa el domini catalític, que conté sobre 200 aminoàcids, destacant les histidines, especialment la H646, i cisteïnes, especialment la C713, localitzada en la tríada catàlica típica (Cys-His-Asp). Aquesta tríada està estabilitzada per una glutamina (Gln). El substrat accedeix al centre actiu a través d'un túnel, on els residus de Trp són essencials per a posicionar l'enllaç. A més l'enllaç scissile bond té forma cis per a millorar l'adherència al SUMO. D'altra banda, consta de regions amino terminals per a facilitar la unió del substrat.

També cal destacar que les seves lisines s'uneixen mitjançant enllaços isopeptídics per la presència del nitrogen com a nucleòfil.

Respecte a la seva estructura proteica cal mencionar que la seva conformació no és totalment clara, se sap que el seu nivell de plegament arriba a l'estructura terciària. Tot i així, podem assegurar que presenta els dominis alfa-hèlix com a cadenes sense estructura definida.

Localització
Les diferents isopeptidases SUMO tenen distribucions subcel·lulars característiques que estan codificades entre els aminoàcids 1 i 168, la qual cosa sembla ser una manera de restringir la seva activitat a un conjunt específic de substrats. Els membres de la família Ulp /SENP es concentren predominantment en diferents regions subnuclears. L'extrem N-terminal de la SENP5 conté un tram d'aminoàcids responsables de la seva localització nucleolar.

No es pot concretar la localització de la SENP5, perquè depèn de la fase de divisió cel·lular, però normalment tant la SENP3 com la SENP5 es troben en el nuclèol, on actuen sobre proteïnes que participen en els primers passos de la maduració dels ribosomes. Una part de les SENP3 i SENP5 també resideix en el nucleoplasma i el citoplasma. D'altra banda, en la transició G2/M, abans de la ruptura de l'embolcall nuclear, la SENP5 migra cap als mitocondris, concretament a la superfície mitocondrial. Això provoca que augmenti la concentració de DRP1, una proteïna relacionada amb l'increment de divisió mitocondrial.

Descobriment
La proteasa SENP5 va ser descoberta per Limin Gong i Edward T. H. Yeh del Departament de Cardiologia  de Houston Health Science Center de la Universitat de Texas, juntament amb el M. D. Anderson Cancer Center, the Research Center for Cardiovascular Diseases, Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, l'any 2005.

El seu descobriment va donar lloc durant la realització d'una consulta per una cerca de seqüències TBLASTN, on es va fer ús d'una seqüència completa de la proteïna SENP1. Es tracta d'una forma de consultar una seqüència d'aminoàcids en vers una base de dades de seqüències de nucleòtids traduïts. En els resultats d'aquesta cerca, es van detectar tres clons positius i que, a més a més, eren homòlegs en l'extrem C-terminal en l'ADN clonat d'una placenta humana. Aquest ADN clonat contenia un marc de lectura obert de 2265 pb que codificava una proteïna de 755 aminoàcids. La proteïna codificada per aquell marc de lectura va rebre el nom de SENP5.

Posteriorment, el descobriment i nomenament de la proteasa va ser publicada l'11 d'abril de l'any 2006 en l'article Characterization of a Family of Nucleolar SUMO-specific Proteases with Preference for SUMO-2 or SUMO-3*,  en la revista de Journal of Biological Chemistry.

La importància de SENP5 durant la divisió cel·lular
Les modificacions de tipus SUMO (Small Ubiquitin related Modifier) estan relacionades amb la formació d'estructures subnuclears, la regulació de la transcripció i la reparació de DNA; entre d'altres. En mamífers hi ha quatre famílies de proteïnes SUMO: SUMO-1, -2, -3 i -4.

La SENP5 té activitat hidrolasa i isopeptidasa; ambdues necessàries per la divisió cel·lular. Estudis han demostrat que l'eliminació del SENP5 amb ARN interferent condueix a una disminució dràstica de la proliferació de les cèl·lules HeLa i l'aparició de moltes cèl·lules amb múltiples nuclis i/o amb nuclis multilobar, indicatius de defectes en la finalització de la mitosi i/o citocinesi. També s'ha vist que la disminució de SENP5 condueix a l'augment dramàtic de les proteïnes SUMOilades, donant a pensar que la des-SUMOilació de proteïnes concretes (mitjançant SENP5) és necessària per a l'arquitectura nuclear normal.

Els cicles ordenats de SUMilació i des-SUMOilació regulen el procés del cicle cel·lular, com la fosforil·lació i desfosforil·lació d'altres proteïnes que també hi intervenen (procés més conegut i estudiat). Per exemple:

 Hi ha dos components dels cossos PML, que són des-SUMOilats abans de la mitosi i re-SUMOilats al principi de la fase G1.
 RamGAP1 SUMOilat és important per a que els cinetocors i els microtúbuls es puguin adherir durant la formació del fus acromàtic.
 La modificació post-traduccional de l'enzim topoisomerasa II amb SUMO-2/-3 es dispara durant la metafase. Seguidament es dona una ràpida desconjugació en l'anafase.

Es suposa que la manca de des-SUMOilació d'aquestes i altres proteïnes en el moment adequat és el que condueix a defectes en la proliferació cel·lular.

Aplicacions mèdiques de SENP5 contra el càncer
Com s'esmenta en l'apartat anterior, la SENP5 és essencial en la divisió cel·lular ja que, executa una funció important en la mitosi i/o citocinesi. Arrel d'aquests descobriments sobre la importància d'aquesta proteasa, es van obrir noves vies d'investigació sobre possibles aplicacions mèdiques de SENP5 contra el càncer.

Segons un estudi  realitzat per l'Universitat de Fudan a la Xina, aquesta protesa es troba sobre-expressada en osteosarcomes, és a dir, en cèl·lules canceroses d'òs, el que inidica que l'increment de l'expressió de SENP5 està relacionat amb la carcinogènesis de l'osteosarcoma. Per tant, això podria significar que l'inhibició d'aquest enzim podria disminuir el creixement, proliferació, migració i invasió en cèl·lules cancerígenes, tal i com es mostra en una altra recerca realitzada pel Departament de Cardiología del M.D. Anderson Cancer Center a Houston, Texas on es va estudiar com les SUMO proteases poden interrompre la SUMO homeostàsi i facilitar el desenvolupament i progrés del càncer.

Respecte a SENP5 com a possible diana terapèutica per lluitar contra el càncer, es sap que la inhibició de la proteasa podria disminuir el desenvolupament i creixement de cèl·lules tumorals en alguns càncers com el de mama, càncer d'òs o de pròstata. Però, tot i això, encara hi han moltes preguntes per resoldre respecte el paper exacte que juga SENP5 en el càncer com, per exemple, si hi ha un canvi de funció o localització en les SENPs de les cèl·lules canceroses o si combinacions d'aquestes poden estar alterades en l'inici i la progressió del càncer, etc. I, per tant, es seguirà investigant com a possible aplicació mèdica.

Referències
Enzims

redpajama_set_name: RedPajamaWikipedia


We have an open import license and would be pleased to act as your U.S. importer for a firearm you have purchased in the United Kingdom or Europe. The import process will take from 6 weeks to several months, with longer being the more common. It's not complicated, but many government agencies must process the application and issue approval. The cost varies considerably and can be substantial for single items. If you are contemplating an importation please call to discuss the process.
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Q: Windows: How do I remove a file's ACL, and just let it inherit the ACL on the containing directory? Scenario: I unpack a file into a temp directory.
Then I movve the file into a different directory.  I want the file ACL to only include the perms stipulated in the new containing directory.  How can I make that happen?
In UI, and in command line would be good.  icacls?

A: You could use the reset function of icacls:
ICACLS "C:\path\to\folder" /reset /T /C
then enable inheritance:
ICACLS "C:\path\to\folder" /inheritance:e /T /C