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You can join BrightTALK's vibrant exchange of ideas as either a viewer or a presenter. They offer viewers live, interactive access to businesses' top thought leaders. You identify the topics most relevant to you by searching communities, channels, summits or individual webcasts and are introduced to new experts via their timely and relevant presentations. Your comments, your ideas, and your voice will not only influence how others think, but can shape future events available for your viewing and participation on BrightTALK. In addition, webcasts are available on-demand for future viewing and for sharing with your peers and colleagues.
They offer presenters the ability to create powerful online events using our easy-to-use webcast platform. Business and industry professionals create and view webcasts through BrightTALK™ Channels. Your presentations and channel can be easily promoted to your existing audiences and can also be exposed to BrightTALK's rapidly growing and vibrant professional communities. As your channel builds its own community, your audience will be continuously exposed to your messaging. They can regularly attend and readily share your presentations by using our simple social media features and by embedding them on their blogs and websites.


text:
Home Archive: Earlier Fringes Archive: Edinburgh '08 Samuel James
Written by Ali Lauder
Published on Monday, 28 July 2008
Jazz and Blues Festival
At the Minto Hotel; Run ended
AT FIRST GLANCE, you wouldn't expect the sedate Minto Hotel to be the setting for a night of innovative traditional-style Delta blues. The lounge is pleasant enough with its dimly glowing red lights, but the huge circular tables and stage tucked in the corner lend an impersonal feeling to the room. But while a raucous blues bar might have suited him better, Samuel James is the type of musician who could play anywhere - and take the spirit of his music with him. And by the end of his set, that spirit had won over everyone in the room.
Hailing from Portland in Maine, the US's most North-Eastern state, it's perhaps surprising that James ended up playing the blues. But everything about him suggests he was born to it and, emulating classic pre-war Delta bluesmen, James is a master of his chosen style. There's nothing disingenuous about him: everything feels real, whether it's his slick suit, his wry-back stories and anecdotes, his heartfelt vocals and playful lyrics that flirt with melancholy and loss, or the guitar playing which takes in all the accepted conventions of the genre but still finds time to create something very fresh and new.
James' anecdotes expose a deep understanding of the blues, its history and his influences, whilst his amiable personality not only serves to entertain and connect with the audience, but enhances the reception of each of his songs. You find yourself listening out for references to his experiences of one-eyed biker girls, (literal) sleeping partners, homicidal girlfriends, heartbreak - and fishing. His set was a well-crafted, thoughtfully balanced mix of originals, covers and instrumentals spanning 16 songs; it ended on the a cappella call-and-response of John the Revelator, by which time the rather subdued audience forgot themselves long enough to join in.
James' own material is made up of wryly humorous songs - mostly concerning romantic mishap - and exploratory instrumentals. As he said at one point, rhythm is kind of his thing: his music revolves around a strong rhythmic base, helped along by the feverish beating of his boot heel. The songs buzz, beat and hum; wander, waver and groove, with slide, chords and finger-picking. But his playing's in stark contrast to his lyrical and vocal style: focussed, technical and precise, it works to raise the profile of a voice which, smoother and less weathered than those of his influences, gives his vocal delivery a truly unique aspect.
However, it is with his interpretations of classic blues numbers that James' formidable talents are really put on show. Including Son House, Mississippi Fred McDowell, Leadbelly, Skip James, Townes Van Zandt, Bukka White and John Lee Hooker, James tackles a diverse mix of covers and makes them all his own. His almost rocking version of Hooker's Hobo Blues incorporated a wildly improvised lap slide solo. Making use of the guitar strings on the other side of the bridge, the other side of the nut and all of them in between, it displayed his flair for tastefully pushing the boundaries of a classic song.
But his extended take on the darkly atmospheric Cherry Ball Blues by Skip James emerged as the highlight of the performance for me. The original a haunting lament featuring Skip James' signature down-tuned guitar buzz and eerie vocals, Samuel James' take grimly meandered before intensifying the original tone into a dark, brooding, multi-textured epic that built slowly to a powerful climax. Once again including slide, finger-picking, tempo shifts and boot-heel percussion, this one had it all.
While it's apparent that James doesn't take himself too seriously, he couldn't be more serious about the blues - and anyone with a love for music would find much to appreciate with the passionate playing of his warm sound. Playing live he is in his element, and tonight he brought authentic blues to an audience hungry for substance - even if they didn't know it until the last few songs. It was a strange choice of venue for a live performance of this kind, but watching James shift from measured love songs to rowdy stomps with carefree abandon, it was clear the incongruous setting hadn't dampened his spirits at all.
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These are archived reviews of shows from Edinburgh 2008. We keep our archives online as a courtesy to performers, and for readers who'd like to research previous years' reviews.
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A data-driven culture drives superior stakeholder experiences and empowers business with a deep understanding of customer's needs. However, the caveat is working with the right data. Analytics is only as accurate as the data fed into the engine. For most enterprises, "Dark Data" creates a severe distortion.
Gartner defines "Dark Data" as "the information assets organizations collect, processes and store during regular business activities, but generally, fail to use for other purposes".
Dark data include data from instant messages, emails, partly developed applications, log files, PDF downloads, and more. Such data, usually stored across a distributed IT environment with no single owner, is difficult to manage. Worse, a large proportion of dark data consist of difficult to classify video, audio and image files.
IDC and Dell EMC estimate 40 zettabytes of data in existence across the world, 2020. A 2016 Veritas Global Databerg Survey indicates about 85% of all data being Dark Data. A survey by IDG estimates dark data growing at a rate of 62% every year. By 2022, 93% of all data will be unstructured. While the importance of analytics and data-based decision is obvious, these statistics indicate the vast majority of the world's consumer and business data remains inaccessible.
The 'save everything, just in case' culture fuels the creation of dark data. Most dark data, thus created never see the light of day again. The Data saved become redundant as employees leave and take the passwords with them, customers move on, and business priorities change.
Dark Data make predictions go awry, inflate client list, and create several distortions enterprises would like to do without. If nothing else, it creates unnecessary bloat, which is not just costly but against the basic principles of the overriding lean philosophy of the day. Storing Dark data also increases security risks manifold.
Enterprises now have an even more compelling reason to get rid of dark data. The new European GDPR requires businesses to have tight control over their data, including how data flows across the enterprise. Enterprises become bound to share the data stored on "data subject," such as client, employee or other stakeholders. Another key feature of the regulation is consumers being able to exercise their "right to be forgotten," which would oblige the enterprise to delete all personal data pertaining to the customer.
A key step in controlling dark data is structuring unstructured data. Standard artificial intelligence tasks such as teaching computers to recognize images or human speech go a long way in properly attributing unstructured dark data. A powerful AI engine may unlock unstructured dark data from social feeds, categorize it, apply predictive analytics, subject it to heuristic analysis, and finally decide whether to retain or discard the data based on merits of the data.
Another key exercise in taming dark data is sorting the wheat from the chaff or identifying which data is beneficial and which data is obsolete. Artificial Intelligence allows identifying useful data with a high degree of accuracy. AI tools enable the enterprise to understand the implications of each piece of data and take appropriate action. Determining what each document is about requires identifying a business problem or question, and pinpointing where the relevant information related to the business problem or question is located within any specific document, if at all. Artificial Intelligence applies context and background knowledge to the analytics, allowing enterprises to perform the exercise with a high level of accuracy.
AI branches such as natural language processing (NLP), computational linguistics and machine learning enable the analytic engine to understand the contexts of information to pull the relevant data for each business problem or question. For instance, applying computational linguistics helps to extract relevant information based on the linguistic context of the words surrounding it.
Artificial Intelligence tools allow enterprises to do these tasks easily, at scale, with the bulk of the process automated.
Across the waste swamps of dark data may lay gems of strategic intelligence. Analyzing unstructured data also offers the opportunity to extract invaluable business insight which would otherwise lie dormant. Here again, Artificial Intelligence offers a solution.
Artificial Intelligence tools allow enterprises to glean insights from dark data. For instance, server log files give clues to website visitor behavior, customer call detail records indicate consumer sentiment and mobile geolocation data reveal traffic patterns. Subjecting such data to analytics allow employees to act based on insights rather than by intuition or hunches.
Retailers traditionally apply psychology in product placements. They understand how customers move around a store, and place products accordingly. Applying Artificial Intelligence tools to video images of shoppers' posture, facial expressions, or gestures offer a deeper understanding of customer psychology, allowing retails and other customer-facing enterprises to position their products and services even better.
In healthcare, it is common for doctors take handwritten notes and capture voice recordings during consulting. Collecting all such information and making it accessible improve treatments and insights manifold, and also contributes to the wider field of medical research in a big way. Without AI tools which properly classifies and gives a context to such data, it remains siloed, inaccessible, and pretty much worthless in the wider scheme of thing.
Data is now a critical source of competitive advantage and success depends on the ability of enterprises to identify relevant data and extract the optimum value out of it. A strong AI-backed analytical engine delivered to key business managers and other stakeholders in the form of customer-friendly apps, is the way to go.
I have been programming since 2000, and professionally since 2007. I currently lead the Open Source team at Fingent as we work on different technology stacks, ranging from the "boring"(read tried and trusted) to the bleeding edge. I like building, tinkering with and breaking things, not necessarily in that order.


Businesses have unique information that they want to record and report on. With analysis codes you can capture additional information and add custom fields so you can report and examine specific areas of your business. Analysis Codes provide you with additional ways to sort and report on your Sage 200c data. You can produce reports using the analysis codes as reporting criteria. You can also filter data in your workspaces using analysis codes.
The analysis code is the type of analysis you want to use. For example, if you want a breakdown of your sales by region, you can create a code of Region.
This is where you specify how you want to analyse the data. For example, if you created an analysis code of Region, the values could be South East, South West etc. By default, the Analysis Codes are named 1-5, e.g. Analysis Code 1. You can change the name of the analysis codes.
Analysis Codes are set up in Accounting System Manager first. Go to Accounting System Manager > Settings > Maintain Analysis Codes. We do have a handy guide on setting up Analysis Codes, complete with step by step instructions and screenshots. Please follow this link to sign up for access to our guides.
In the Sage 200c 2017 Professional release, nominal analysis has changed. Following customer feedback, Sage has added the ability to store analysis codes on each nominal record to allow for greater depth of analysis. Reporting vastly improves, given that nominal is the core area of the product.
Some of the new features include additional criteria on reports and enquiries, also having the ability to import nominal accounts to make processing faster.
So, what are Transaction Analysis Codes?
They are well suited for short term transaction analysis needs, for example, if you want to track transactions that have arisen from a particular marketing campaign.
You can add new analysis codes whenever they are needed and easily remove the codes when the analysis is no longer necessary. This prevents lists of unused redundant analysis descriptions remaining.
Reports are the most common way to extract information about your business. Sage has a number of default reports you can use to review many aspects of a business. Users can also customize any of the reports to suit the business needs. Using Report Designer, you can open an existing report, amend it and then save it as a custom report. At itas, we offer Report Designer training, click here for more information.
List Views are a simple way of displaying the information stored for each module. You can use lists to find and analyse information, open related windows, perform actions on the items, and generate reports.
Summaries provide you with a visual overview of areas of the business and help you assess your business performance quickly, you can select summaries from the Summaries option in the Navigation Area Menu view, or from within the Workspaces option.
Workspaces provide an alternative to enquiry screens to view and analyse the information stored across Sage 200c, you can select workspaces from the Enquiries section of the relevant section of the menu or from the Workspaces section.
Excel reports enable you to extract, view and analyse information from your system. Sage already has provided a number of excel reports within the system and others are available to buy.
I hope this blog has given you more insight on using Analysis Codes, if you would like to give any feedback or any ideas on any future blogs please contact us.


This is a brand page for the LITTLE BABY FACE FOUNDATION trademark by Little Baby Face Foundation, The in New York, NY, 10021.
Write a review about a product or service associated with this LITTLE BABY FACE FOUNDATION trademark. Or, contact the owner Little Baby Face Foundation, The of the LITTLE BABY FACE FOUNDATION trademark by filing a request to communicate with the Legal Correspondent for licensing, use, and/or questions related to the LITTLE BABY FACE FOUNDATION trademark.
On Tuesday, March 2, 2004, a U.S. federal trademark registration was filed for LITTLE BABY FACE FOUNDATION. The USPTO has given the LITTLE BABY FACE FOUNDATION trademark serial number of 76578807. The current federal status of this trademark filing is CONTINUED USE NOT FILED WITHIN GRACE PERIOD, UN-REVIVABLE. The correspondent listed for LITTLE BABY FACE FOUNDATION is MARY B. AVERSANO of KRAMER LEVIN NAFTALIS & FRANKEL LLP, 919 THIRD AVENUE, NEW YORK, NEW YORK 10022 . The LITTLE BABY FACE FOUNDATION trademark is filed in the category of Insurance & Financial Services , Education and Entertainment Services , Medical, Beauty & Agricultural Services . The description provided to the USPTO for LITTLE BABY FACE FOUNDATION is Charitable fund raising.
Trademarkia-Network law firms can help you incorporate a business around your LITTLE BABY FACE FOUNDATION trademark in less than 5 minutes. Trademarkia makes the process easy and convenient, so start now!
MARY B. AVERSANO is a correspondent of LITTLE BABY FACE FOUNDATION trademark.
LITTLE BABY FACE FOUNDATION is providing Charitable fund raising.


If you're looking into easy ways to organize your bedroom and make it look well put together, then you don't have to work hard to find them. There are plenty of simple DIY projects and items you can buy to make things ordered but stylish. And you don't have to spend a whole lot of money just to make your bedroom look great and clutter free.
Down below I've found some awesome hacks for making your room a bit more livable and lovable. With even just a few of these items, your room will be well put together and organized. There's no need to spend hundreds of dollars to make your bedroom look chic but sensible. So check out my finds down below and be sure to head to the bottom to check out the tutorials!
This is a super easy way to keep things from getting cluttered and looking trendy. As a simple DIY project, you can showcase your most used items and decorations.
If you've got a lot of tights (or scarves), this is a great hack. Just use some clothespins to hang and organize them all from getting tangled up in your drawers.
Alright so I know I've already talked about a pegboard for storage, but this one is great. It's big enough to hold a lot more than just a few small items. Also, it adds a nice splash of fun color in your room!
Now you can either make this yourself, or buy a budget friendly version of this and paint it. Whichever is simplest for you so you can get some extra storage in your room while dividing it up nicely!
Now this tutorial was originally meant for people who wanted to organize their tights, but I think it's a great way to get your scarves organized as well!
If you're an artist or work a lot in your room, then this is a great way to keep things clean with your utensils. That and it adds just a bit of cuteness to the room.
Sweaters take up a lot of space, and this is a great way to get them off of your bedroom floor and hung up in a way that's not going to stretch them out.
If I haven't already convinced you that wall storage is an efficient and super cute way to get your room organized, then here's another example of an easy DIY project to get things up and out of the way.
Who says organization ideas have to be plain and practical. Why can't they be colorful, creative, and fun? Well thanks to Pinterest, a lot of awesome DIY ideas have been able to get out there and spark our creativity.
Now if you have any awesome bedroom organization ideas yourself, let me know in the comments below!


Crash after displaying splash screen.
I run Ubuntu 6.10 and have monodevelop 0.12-0ubuntu2 installed.
It crashes on startup after displaying the splash screen and loading some stuff.
The most important line from the console output I think is..
"MonoDevelop.Core.AddIns.MissingDependencyException: Required add-in not found: MonoDevelop.Core v0.10.0"
I think that version ought to be v0.12.0 but I might be crazy.
Closing this bug since no more information has been provided, feel free to re open it if you're having the same problem in the future.


not sure about going back to the Vancouver Games in BC. It was so small, only 8 clans including us and no Livingstone/MacLea visitors. Seattle/Enumclaw would be nice to go to again, loved the place our tent had, right by one of the stages. But it may overlap with the Glengarry Ontario games. hoping Seattle Games are the last weekend in July, Glengarry is the 1st weekend in Aug. Glengarry isnt for sure yet. As it would mean traveling by car at least 4 days one way or the cost of flying but it would be nice to do just once. Plus it would give me a chance to visit where my family resided over there. And possibly find some more information. Pleasanton definitely would like to do again.
Looking for other possible games to attend. the website http://www.sshga.org for the seattle games, lists a lot of the Highland games in Oregon, Montana, and Washington including a few other states. Most seem to be smaller one day events.
I have some answers for you on your list and some ideas. I will send that over to you by email. I just got back from the Longs Peak Scottish/Irish Festival and Highland Games about 8 last night and have to get ready for another one this weekend so it might take me a little while to get that to you. Here are a few quick answers on what I do.
2. Make a PVC pipe frame. Then put grommets in the banner. Use electrical zip ties to attach the banner to the frame. The frame should have legs at each end to hold it up and then you can zip tie it to the frame of the tent to keep it in place.
7/8. take a look at Amazon. There are a lot of books there that are good. I will send you a list of what I have, so far, and others that are good to have.
9. Kyle and I are working on this. We will let you know what we come up with.
10. Kyle has a contact for these clan crest stamps that are self inking.
11. I always have something handy for the children (candy) and something for the adults.
I'll send you more details later.


text:
Q: writing JavaScript for different clients Basically, my question is about managing/writing client side (javascript) for multiple business rules which differ across multiple clients.
Lets say, for example, that I have config.js where I have one flag that decide I need to perform logic for client A or Client B
Config.js
TestBoolFlag = true;

In Angular controller, I am injecting data from config.js and then using if else to decide i need to perform logic for client A or for Client B
Angular controller
var total = 500;

if (TestBoolFlag) {
    var discount = total / 1000 *100;
} else {
    var discount = total / 10 *10;
}

I am just giving basic example of my problem.
This way I am managing so many flags and so many if else statements.
Is there any better way writing javascript code for multi clients need?
Like, get rid of this flag, divide if else into two javascript files and inject one of them depending on client? etc
Can someone please suggest

A: I would suggest that you use a database here to save client specific configurations and not hard-code it into the source code.
This way you can easily scale to more clients.

redpajama_set_name: RedPajamaStackExchange


These relationships can yield mutually beneficial results for both the client and the advisor alike. So many fans took it literally that Cooper had to issue a statement, reassuring them: As you start, move your leg simultaneously with the band movement asymmetrical load — very light but just right to enhance stabilizers across the kinetic chain.
After the husband and wife authors were involved in two African plane crashes innewspapers reported that both had died. I chose 2 weeks as it rounded out the number nicely. Shortly afterwards he announced he was still alive and would be giving a 'Resurrection Recital', which was accompanied by go-go dancers he often played pranks to annoy the musical establishment.
The primary purpose of this article is to offer a balanced perspective to those who may be interested in such a career path regardless of industry focus or subject matter area.
Giffords was one of numerous people shot during a meeting with constituents outside a grocery store in Tucson, Arizona on January 8, It is at that time when a new hire has a choice to make. On hearing that Mrs Ritter was "gone", the friend telephoned the Telegraph obituary editor.
The fraud came to light when a genealogist investigated the incorrect date of birth published in the obituaries. On May 15,he left his wife Marylou five months pregnant their three kids, and five years of unpaid income taxes, sailing out on Lake Erieand vanished right after increasing his life insurance policy.
Key Metrics I touched on chargeability earlier but felt it was important to expand upon the topic, given its underlying significance. This progression puts more demand on the core musculature and requires efficient coordination throughout the movement.
Weeks after the accident, when concerned hospital staff asked her her name, she wrote 'Whitney Cerak', which was confirmed by dental records.
Grey herself took to Twitter to dispel such rumors. It all depends on the need at the time. Apparently as a result, Garvey suffered a second stroke and died. In Octoberthis year-old man was taken to a hospital near Buffalo, New York after suffering a heart attack.
After the husband and wife authors were involved in two African plane crashes innewspapers reported that both had died. Another rumor was that he died from an overdose. Advisory, on the other hand, is more similar to a classic management consulting mold.
The report caused the hashtag RIPBeyonce to become trending on Twitter, even though she is still living. In March the then- Vanderbilt University president was declared dead by a fake edition of the university's student newspaper The Vanderbilt Hustler, sparking early dismissal from classes, tears, and moments of silence.
Advisors at professional services firms sell the space between their ears. Sold opportunities need your skill set but the internal engagement manager did not feel you were the right fit for the project.
The body bore an uncanny resemblance to Dennison — even with similar scars and leg ulcers — leading police to ask whether he had had a twin brother. She was ultimately pardoned, and became something of a celebrity.
You will know your core is weak if your lower back comes off the ground and repositions. Sold opportunities need your skill set but the internal engagement manager did not feel you were the right fit for the project. Firms as you might expect are structured in such a way as to meet client demand.
An opportunity eventually came up which landed me in California for a successful two-month gig. The article was published on the internet after Queen Elizabeth II had called an emergency meeting to announce that the Duke was going to give up his royal engagements.
Does he or she exhibit leadership potential? The way we train the core has changed in recent years, largely due to the research of Dr. Thinking it was for real, he phoned his mother in Australia with the 'news', who passed it on to the media.
The press release was a hoax; Ferrell had never been paragliding. The body bore an uncanny resemblance to Dennison — even with similar scars and leg ulcers — leading police to ask whether he had had a twin brother.
To be clear, this article has not been written under the guise of any Big Four recruiters. As you pull the band to the right, your left leg is lengthened extended and vice versa.STACK Expert Kelvin King Jr.
recommends adding advanced Dead Bug variations to your core routine to reap the benefits of this great exercise. David Adkins, known professionally as Sinbad, was the subject of a death agronumericus.com March 14,it was reported that the comedian had died of a heart attack.
He later spoke with a reporter from the Associated Press about the hoax.; Ali Hassan al-Majid was supposed dead in April (), after British and United States officials reported that he had died in an air strike in Basra; al-Majid had.
In "Dead Men's Path," Michael Obi becomes headmaster of a small secondary school in the village of Ndume. He plans to revitalize the school, instituting new, more progressive methods of teaching. An Intentional Plan of Discipleship. Disciples Path is a series of resources founded on Jesus' model of discipleship.
It was intentionally created to make disciples who make disciples. David Adkins, known professionally as Sinbad, was the subject of a death agronumericus.com March 14,it was reported that the comedian had died of a heart attack. He later spoke with a reporter from the Associated Press about the hoax.; Ali Hassan al-Majid was supposed dead in April (), after British and United States officials reported that he had died in an air strike in Basra; al-Majid had.


In July I presented some aspects of my work with the Orchestra of Speech project at the New Interfaces for Musical Expression (NIME) conference, this year held at VirginiaTech in Blacksburg, VA.
I contributed with a short paper and a poster presentation where I presented a scaled down version of the sound installation version of the project, with telephone interaction encouraging audiences to pick up the phone and interact with speech recordings being orchestrated out simultaneously to transducers mounted on a selection of acoustic instruments. Also got a mention from Gregory Taylor at Cycling74 in his blog report from the conference.
This entry was posted in presentation on 09/07/2018 by daniel.


Take a unique approach to exploring Lille on two wheels with this 2-hour bike tour of Lille. Hop onto your bicycle, an authentic and comfortable Dutch model, and follow your guide through Lille's attractive streets. During your two hour cycling adventure, discover popular sites of interest alongside hidden hotspots known only to the locals. Spin along the banks of Lille's tranquil waterways, and listen as your guide shares insight into the city's rich history and heritage.
Get to know Old Lille, the city's most charming district, on a walking tour with a knowledgeable guide. As you explore the streets, admire historical architecture and pass by shops and monuments such as the Opera House, Palais Rihour and Notre-Dame de la Treille.


5 The Texas Children's Hospital, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
6 Molecular Medicine Unit, Institute of Child Health, University College London, London WC1N 1EH, UK.
7 Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, V5A 1S6, Canada.
Bardet-Biedl syndrome (BBS) is a genetically heterogeneous disorder characterized by multiple clinical features that include pigmentary retinal dystrophy, polydactyly, obesity, developmental delay, and renal defects. BBS is considered an autosomal recessive disorder, and recent positional cloning efforts have identified two BBS genes (BBS2 andBBS6). We screened our cohort of 163 BBS families for mutations in both BBS2 and BBS6 and report the presence of three mutant alleles in affected individuals in four pedigrees. In addition, we detected unaffected individuals in two pedigrees who carry two BBS2 mutations but not aBBS6 mutation. We therefore propose that BBS may not be a single-gene recessive disease but a complex trait requiring three mutant alleles to manifest the phenotype. This triallelic model of disease transmission may be important in the study of both Mendelian and multifactorial disorders.
Locus heterogeneity in Mendelian disorders is the phenomenon whereby mutations in different genes result in a similar or identical clinical phenotype. In most reported instances, mutations at a single locus suffice to cause disease, although rare cases have been reported where mutations at two loci are necessary for pathogenesis (1) or exacerbate the severity of the phenotype (2, 3). BBS is a typical example of a rare, genetically heterogeneous disorder. BBS patients manifest a complex and variable phenotype that includes pigmentary retinal dystrophy, polydactyly, central obesity, hypogonadism, learning difficulties, and renal dysplasia; additional features such as asthma and diabetes mellitus may also be present (4, 5). The segregation of the disorder in families and population isolates led to the hypothesis that the syndrome is inherited in an autosomal recessive manner. On the basis of this model, six BBS loci have been identified: BBS1 on 11q13 (6),BBS2 on 16q21 (7), BBS3 on 3p12 (8), BBS4 on 15q22.2-q23 (9),BBS5 on 2q31 (10), and BBS6 on 20p12 (11), with evidence for at least one more locus (12). Two BBS genes have been cloned recently:BBS6 (11, 13), which encodes a putative chaperonin (14), and BBS2, which encodes a protein of unknown function (15).
During our analysis of BBS6 in 163 patients, we identified eight pedigrees with mutations. A high frequency of these (seven of eight) harbored only a single mutant BBS6 allele (12). Furthermore, we described one consanguineous pedigree in which both the affected and unaffected sibs carried a heterozygous A242S mutation in BBS6, but the affected sib also exhibited homozygosity by descent (HBD) across the BBS2 locus. This observation suggests either that BBS arises through multiallelic inheritance or that the A242S allele is a rare polymorphism (12).
The recent identification of BBS2 enabled us to test the former hypothesis by screening the same cohort of BBS patients (16) for coding sequence alterations inBBS2, irrespective of haplotype-inferred chromosomal assignment for any given pedigree or previously obtained mutational data for BBS6. Upon deducing the intron-exon structure ofBBS2 (17), we designed suitable primers and amplified and sequenced each of the 17 exons of this gene in our entire patient cohort (18).
We identified numerous sequence alterations. In 19 unrelated patients (Table 1), the alterations fulfilled our minimal criteria for mutations, in that they caused a nonconservative amino acid change and that they were not found in a minimum of 192 control chromosomes from ethnically matched samples (19). Initial segregation analyses confirmed thatBBS2 mutations were likely to be pathogenic. We identified six pedigrees (AR171, PB005, PB020, PB026, PB058, and K059) in which two independent mutations segregated with the disease (Table 1) (20). However, despite complete DNA sequence coverage of theBBS2 open reading frame (ORF) and exon-intron boundaries, we identified only a single mutant allele in eight pedigrees. We considered four possible explanations for this result: (i) the single alleles found may not be pathogenic but rare polymorphisms, (ii) by chance alone, we were detecting rare BBS2 carriers, (iii) the second mutation might reside in the regulatory regions or introns of BBS2 or might be undetectable by sequencing because of deletions of the whole or part of the gene, or (iv) additional mutations lie in another gene, and it is the combination of mutant alleles at two or more loci that causes the BBS phenotype.
Mutational, genetic, and phenotypic analysis of pedigrees with mutations in BBS2. The different aspects of the BBS phenotype in each pedigree are indicated as present (+), normal (Nml), or not recorded (NR). The primary features of BBS were examined: retinitis pigmentosa (RP), obesity (Ob), polydactyly (PD), developmental delay (Dev), and renal (Ren) and gonadal malformations (Gon). HBD, homozygous by descent; the "fs" annotation for some mutations indicates a frameshift; IVS, intervening sequence. *, **, ***, and **** indicate recurrent mutations.
The first hypothesis is unlikely because changes caused by several of the "singleton" mutant alleles are predicted to be severe (Table 1). For instance, conceptual translation of the single mutation in pedigree AR124 causes a frameshift affecting a valine at position 158 and then results in premature termination of translation at position 200 (V158fsX200; Fig. 1 and Table 1). Likewise, the mutation found in pedigree AR050 was an arginine to STOP (R275X), also causing premature termination (Table 1). Furthermore, this R275X mutation was also found in the homozygous state and segregated with the disorder in pedigree PB005 (20). None of these alterations were found in 192 ethnically matched control chromosomes.
Pedigrees with one BBS2 mutant allele that have been excluded genetically from the BBS2 region. In AR124, the two affected siblings carry different maternal chromosomes. In AR238, the pedigree is excluded from BBS2 because the single affected sib AR238-04 has an identical haplotype to that of unaffected sib AR238-06. The genotypes across the BBS1critical interval (31) of both pedigrees are also shown, where the haplotypes are consistent with linkage.
The possibility of incidental detection of BBS carriers is even less likely. The frequency of BBS is 1:125,000 to 1:150,000 in the European and North American populations (4). Furthermore, the contribution ofBBS2 to all BBS has been estimated at about 10 to 20% (12, 15, 21), which at Hardy-Weinberg equilibrium leads to an expected carrier frequency of 1:400 to 1:700 for BBS2. Therefore, the association of five mutations with BBS2 (in North American pedigrees AR050, AR124, AR237, AR238, and AR596; Table 1) in a sample of 163 patient DNAs is significant (χ2 = 52.9; P < 0.0001).
We explored the possibility that the second mutation was not located in the ORF or was a large deletion by genotyping microsatellites around BBS2 and examining whether the segregation pattern of the parental chromosomes in any given pedigree with a single mutation was consistent with linkage toBBS2 (22). Six (of eight) pedigrees provided sufficient information for this investigation. Only one pedigree, AR029, was consistent with linkage to BBS2. The remaining five pedigrees could be excluded genetically from BBS2either because the affected individuals shared only one parental chromosome at the locus (e.g., AR124; Fig. 1) or because the affected and unaffected sibs had inherited the same parental chromosomes and both were carriers for the single mutation found. Despite the dense microsatellite spacing, there remained a remote chance that a recombination between any marker and the locus might have led to a deceptive exclusion; we eliminated this possibility by genotyping all individuals with a highly informative single nucleotide polymorphism in exon 3 of BBS2 (Fig. 1). When we used polymorphic microsatellites from all BBS loci to monitor the segregation of the parental chromosomes, we observed that three out of five pedigrees could be excluded from all BBS loci except forBBS1, the major BBS locus, suggesting that these three pedigrees may harbor BBS1 mutations. One pedigree was consistent with mapping only to BBS3, and one pedigree, AR237, could be assigned to BBS6 (Fig. 2A).
Pedigrees carrying three BBSmutations. (A) Pedigree AR237 has two BBS6mutations and one BBS2 mutation; (B andC) the converse is the case for pedigrees NFB14 and AR579.
These data suggest that mutations at more than one locus may be present in BBS patients. We therefore integrated and expanded all sequence data from the BBS2 and BBS6 mutation screens that yielded a complete scan of the ORFs of the two genes, and we constructed detailed haplotypes across both genomic regions. Of the 19 pedigrees with one or two BBS2 mutations, we identified four pedigrees with a third potential mutation (AR237, AR579, NFB14, and PB043). AR237 was reported in our initial discovery ofBBS6, because it harbored a homozygous Tyr37 → Cys (Y37C) mutation inBBS6 (11). We then found a heterozygous Asn70 → Ser (N70S) alteration in BBS2 in this family (Fig. 2A and Table 1). In AR259, we found two heterozygousBBS2 nonsense mutations [Tyr24 → X (Y24X) and Gln59 → X (Q59X)] and oneBBS6 nonsense mutation [Gln147 → X (Q147X)]. Similar findings were seen in pedigrees AR579 and NFB14 (Table 1and Fig. 2, B and C).
The probability that we had detected three mutant alleles by chance is minuscule, given the rarity of this disorder and the observation that BBS6 contributes only ∼4% to BBS (11, 12). That the third allele is not a mutation is possible but is not likely. First, nonsense mutations are unlikely polymorphisms. Second, the Ala242 → Ser (A242S) allele identified in NFB14 has been observed on two other occasions, once in the Old Order Amish, associated with McKusick-Kaufman syndrome (14), and subsequently in a BBS patient, but not in 384 control chromosomes (Table 2). The N70S (BBS2) and Cys499 → Ser (C499S) (BBS6) alleles are more challenging to interpret in the absence of a functional assay for either gene, but neither has been found in 384 control chromosomes. More importantly, however, the cumulative data indicate that, among 19 pedigrees with BBS2mutations, sequence or genetic evidence for involvement of another locus occurs in at least nine families (47.3%). The same is also true for BBS6: Of the eight outbred pedigrees where mutations have been identified (12), three harbor BBS2mutations (37.5%). The combination of the genetic data described earlier and the mutational data for the only two genes known to be mutated in BBS suggest that multiple alleles may act in concert to cause pathogenesis. We therefore propose a model of triallelic inheritance, in which three mutant alleles segregate with the disorder.
In the absence of either complete gene identification for allBBS loci or an animal model, it is not clear whether two mutations at a single locus may sometimes suffice to cause BBS. The recessive segregation pattern in several BBS2 pedigrees initially suggests that this may be the case and that "biallelic" inheritance may occur for some instances. However, the BBS6homozygous Y37C mutation in pedigree AR237 segregates perfectly with the disease, yet this pedigree harbors an additional BBS2mutation (Fig. 2A). In fact, in three additional pedigrees, three disease alleles are identified in affected individuals: twoBBS2 alleles with one BBS6 allele (Figs. 2, B and C, and 3). Consistent with our triallelic hypothesis, individuals with two mutant alleles at BBS2 who are either wild type forBBS6 (AR259-05; Fig. 3) or map genetically to another locus (BBS4 in PB043; Table 1) are unaffected. The absence of these alterations in 384 control chromosomes and the nature of theBBS2 mutations in AR259-05, in particular (Y24X and Q59X), suggest that these are not polymorphisms (Table 2).
Pedigree AR259 carrying three nonsenseBBS mutations. Individual AR259-05 carries two nonsenseBBS2 mutations but no BBS6 mutations and is phenotypically normal.
Inheritance of multiple alleles has been documented previously. Paired single mutations in ROM1 and RDS, for example, are the cause of some cases of retinitis pigmentosa (1). Subsequent functional studies confirmed these genetic observations by modeling the mutations in vitro and showing defective assembly of the ROM/RDS complex (23). Dominant Hirschsprung disease also provides a similar, potentially digenic example, where mutations in both RET and GDNF were found in patients (24, 25). However, given that knockout mice for either gene display the Hirschsprung phenotype (26–29), it is likely that the combination of mutations modulates the severity of the phenotype. Likewise, in recessive junctional epidermolysis bullosa (JEB), mutations in bothCOL17A1 and LAMB3 lead to a phenotype with features of both severe JEB (Herlitz form, associated withLAMB3 mutations) and generalized atrophic benign epidermolysis bullosa (caused by COL17A mutations) (30). In contrast, we have no evidence that the differentBBS mutations modulate the phenotype (Table 1), although in principle, the phenotype/genotype relationship may be the combinatorial result of both the type of mutation at each locus and the number of loci involved.
The frequency of multiallelic inheritance in recessive, genetically heterogeneous disorders is unclear. A model of a dominant loss-of-function mutation requisite to unmask recessive mutations may explain, however, the genetic heterogeneity seen in many instances in inbred populations, where both one dominant and two recessive mutations are required for pathogenesis. This model is similar to the inheritance patterns seen in some complex traits, such as type I diabetes (IDDM1), where a dominant HLA genotype is necessary but not sufficient to cause disease; a second, recessively inherited alteration must also be present (31). The presence of a common dominant "master locus" but variable "partners" may also explain the inconsistency in replicating genetic linkage data from discrete populations in various complex traits such as asthma, diabetes, and schizophrenia, because each population isolate will be enriched for a limited number of the recessive mutations that, by themselves, will not satisfy all genetic criteria for pathogenicity. A modification of the theoretical model of disease transmission in these disorders may provide important insights.
To our knowledge, there is only one other clearly documented mechanistic example with a three-allele requirement to manifest a Mendelian trait, exemplified by the segmental duplication associated with Charcot-Marie-Tooth neuropathy type 1A (CMT1A). That model, however, represents a dominant trait requiring three copies (alleles) of a normal gene to manifest disease (32). Our observations on BBS described herein are distinct from the CMT1A mechanism and different from a digenic model in that a combination of three distinct alleles from two (or more) loci appears necessary and sufficient for trait manifestation. As such, triallelic inheritance may represent a transmission model that bridges classic Mendelian disorders with complex traits.
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The diagnosis of BBS was based on established criteria in which three of six cardinal features must be present (4). In several cases, the diagnosis was ascertained by local physicians and verified through extensive examination of medical records by one or more of the coauthors.
The published cDNA sequence for BBS2 (GenBank accession number ) was screened through the assembled human genomic sequence with the BLAST algorithm (www.ncbi.nlm.nih.gov/genome/seq/HsBlast.html). Assembly scaffold NT_024816.3 exhibited >99.5% identity to the cDNA sequence. The sequence was downloaded and aligned with the BBS2 cDNA with programs from the GCG software package (11). The sequence flanking all coding exons was identified, and primers were designed to amplify both exons and intronic splice junctions with the Primer v3 program (www.genome.wi.mit.edu/cgi-bin/primer/primer3.cgi).
Amplified polymerase chain reaction products from patients, relatives, and control samples were sequenced (11). BBS2 exon amplification primers are available at www.imgen.bcm.tmc.edu/molgen/lupski/index.htm.
Sequences were aligned with the wild-type cDNA and genomic sequences, and alterations were confirmed on both strands and evaluated by the Sequencher sequence alignment program (GeneCodes, Ann Arbor, MI).
Examples of Mendelian recessive segregation of mutations are shown for pedigrees AR171 and PB005 and are available as supplemental Web material on Science Online at www.sciencemag.org/cgi/content/full/293/5538/2256/DC1.
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Microsatellites D16S411, D16S415, D16S419, D16S390, D16S408, D16S526, D16S3089, D16S265, D16S3034, D16S408, D16S3057, D16S514, D16S503, D16S400, D16S421, and D16S515 were genotyped in all available pedigrees, and haplotypes were constructed (33).
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We thank the families and the referring physicians for their cooperation and A. Beaudet, H. Bellen, and J. Belmont for constructive comments. Supported by grant EY12666 from the National Eye Institute (NIH) (N.K.), the March of Dimes (N.K. and J.R.L.), the Foundation Fighting Blindness, USA (R.A.L. and J.R.L.), the Canadian Institutes of Health Research (W.S.D.), the National Kidney Research Fund (B.E.H.), the Birth Defects Foundation, and the Wellcome Trust (P.L.B.).


At several sites, guardian stones have been so arranged that the corner blocks jut out at an angle from the phalanx of stones. For example, the simple dolmen of Frauenmark, Parchim county, and the passage grave of Mellen, in the county of Prignitz. At the large passage grave of Naschendorf, Nordwestmecklenburg all the blocks at the narrow end are arranged in a concave way, so that the corners are very prominent. The same shape is seen at the wide end of the trapezoidal bed of Kruckow, Demmin county.


I'm sure I'm not the only one to notice the rising prices of groceries over the last year or so. It seems crazy to me that wages are frozen, jobs openings are down, and yet prices of food and services continue to rise. It's because of this that so many have started couponing.
There are so many sites out there that can help you find all those deals out there, so I won't go into that part of things. But I will tell you about a site you can join that will occasionally send you out coupons for free products or large value coupons to try products on the market (like salads, fruit snacks, breakfast foods and laundry products to name a few). If you haven't already, think about joining Vocal Point.
I joined up about two years ago, and haven't regretted it. I'm not as active in the forums over there as I could be, since I have my hands pretty full as it is. But I still get clued in on the freebies and other offers they have going on. They give you a place to talk about what you like and don't like about the products you're buying too. This is so the consumer can point the manufacturers in the right direction when making products.
And no, I don't get paid or rewarded for referring anyone there. I'm just here to help those like me who are always looking for ways to save. Though if they offered to pay me, I'd hardly turn them down! Haha! Anyway, I thought I'd let you know, in case any of you were interested. After all, every dollar saved means more in your pocket--no small thing in a down economy!
Hi Nellie – my name is Aaron and I work for Vocalpoint. I just wanted to let you know that we are glad you enjoy the site and appreciate the positive feedback.


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package org.powermock.api.mockito.verification;

public interface ConstructorArgumentsVerification {

    void withArguments(Object argument, Object... additionalArguments) throws Exception;

    void withNoArguments() throws Exception;
}

redpajama_set_name: RedPajamaGithub


We've performed in venues such as the iconic Bluebird Cafe Nashville, The Billy Block Show & Hotel Indigo Nashville, House of Blues (Myrtle Beach), Sylvia Theatre, Historic Puckett's Farm, & Caesar's Palace Las Vegas. We also perform on a lot of festivals, state fairs & fundraiser events.
*Sang the National Anthem on SPEED TV's "Pinks ALL Out" Episode at zMax's Dragway in Charlotte, NC, the Coca Cola 600 pole-night, the 2010 "Legends MILLIONS Race", 2011 Top Gear 300 Nascar Race, and Charlotte's 2011 "Wounded Warriors Soldier Ride"
*GF rocked the stage in both 2011 & 2012 at Charlotte, NC's Race week Festival, called Speed Street Festival, where they opened up for American Idol star Casey James, and also Clay Walker.


Tim Nicholson, chief executive of the Recruitment and Employment Confederation (REC), has decided to stand down after nearly three years in the post.
Nicholson, who oversaw the merger between FRES and the IES in January 2000 from which the REC emerged, is to stay in his position until the end of the year.
He said: "REC was launched into a time of rapid change and uncertainty, and a difficult combination of regulatory pressures and tough market conditions has challenged all of us to find the right ways forward.
Nicholson played a pivotal role in the merger of FRES and IES which had previously represented the recruitment industry.
REC chairman Keith Faulkner said: "While we will be sorry to see Tim go, we fully concur with his thoughts on timing and the Board is being given time to find and settle in a new CEO.
"REC has become a pro-active, well-connected, issue driven organisation that looks for constructive solutions whilst ensuring members' interests are identified, debated and powerfully presented.


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Orange County Moves Forward With Project Homekey as Roomkey Ends
A homeless man walks in the middle of the road in Santa Ana, Calif., on Dec. 17, 2020. (John Fredricks/The Epoch Times)
Orange County Spends $32 Million of CARES Act Funds on Homeless
By Brad Jones and Tara MacIsaac
As one would expect with federal funding aimed at helping the county through the pandemic, much of the CARES Act funding in Orange County, California, was spent on health care costs. But aid to businesses was the biggest expense, and helping the homeless was also in the top three, according to a breakdown provided to The Epoch Times by the Orange County Auditor-Controller's office.
Interest in how the money is being spent has increased as the Dec. 30 deadline to spend the funds approaches.
The auditor-controller's office is working on putting together more detailed information about the spending, spokesperson Danielle Ortiz said. Molly Nichelson, a county public information officer, told The Epoch Times that full accounting of how the funds have been spent won't be available until Jan. 15.
According to the preliminary breakdown sent by Ortiz, Orange County spent $75 million on small businesses out of its total $554 million in Coronavirus Aid, Relief, and Economic Security (CARES) Act funding.
The next highest expense was health care agency payroll, at about $57 million, followed by spending on the homeless population of about $32 million.
The last point-in-time count of homeless people in the county, pre-pandemic, showed about 6,900 homeless, though it remains unclear how much that population has grown amid pandemic-related economic hardships. The county's total population is about 3.2 million.
Share Our Selves (SOS) Director of Social Services Michael McGlinn told The Epoch Times in September that his food pantries used to get 170 visitors per day, and it's now risen to almost 300 per day. David Gillanders, executive director of Pathways of Hope, said at a roundtable in November that his organization's food distribution program has gone up from 30 per day to 150 per day during the pandemic.
The county also spent $5.5 million in CARES money on Project Roomkey, which rented hotel rooms for at-risk homeless people.
The breakdown of spending shows about $30 million going to hospitals, many of which have been strained, impacting the whole county's status for lockdown mandates.
State-mandated stay-at-home orders kick in when intensive care unit (ICU) capacity drops below 15 percent. Reports of people in critical need unable to get help due to crowded hospitals have circulated throughout Southern California.
Testing for COVID-19 cost about $28 million of the federal funds. Mental health programs received almost the same amount.
Sums ranging from about $10 million to $20 million were dedicated to telework capabilities, medical supplies, alternate care sites, restaurant heating and lighting, child care providers, and emergency protective measures.
Contact tracing cost about $9 million. COVID research got about $8 million. Communication and translation cost about $7 million, as did personal protective equipment. County employee sick and family leave cost about $6 million.


1. Heat oven to 350°F. Place about 28 small foil bake cups (2-inch diameter) on cookie sheet.
2. Follow package directions to prepare brownie batter. Fill bake cups 1/2 full with batter.
3. Bake 12 to 15 minutes or until set. Cool on cookie sheet.
4. Combine frosting and food color. Set aside 6 brownies to use for tree trunk; frost remaining brownies. Arrange frosted brownies on large try in a tree shape. Place the unfrosted brownies at base of tree for the trunk. decorate tree by placing one foil-wrapped chocolate on each frosted brownie. Remove wrappers from 6 chocolates. Place a small amount of frosting in center of unfrosted brownies; place an unwrapped chocolate piece over frosting. About 28 brownie cups.


Browse our range of Aldo sandals to perfect warm-weather chic or late-night glamour. Take your evening look to new heights in heels or go for practical flats to stay comfortable when there's walking to be done. Versatile colours and polished accents lend a refined finish to your ensemble. Complement your Aldo women's sandals with a coordinating clutch or tote bag to round things off in subtle and sophisticated style.


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Google Issues Emergency Security Patch For Billions Of Chrome Browser Users, Update ASAP
by Paul Lilly — Tuesday, February 15, 2022, 11:50 AM EDT
If you're using Google's Chrome browser your Windows PC, Linux system, or Mac computer, be sure you have the latest version installed (version 98.0.4758.102). That's because the latest update contains several security fixes, including an emergency patch for a zero-day vulnerability that Google says is being actively exploited in the wild.
That specific vulnerability is listed as CVE-2022-0609 and unfortunately there is very little information about it at this time. Or fortunately, as Google often holds off divulging the nitty-gritty details about such things until users have had a chance to apply the update. Otherwise, it just brings to attention another attack vector for hackers before the majority of users are properly protected.
It's simply described as a "Use after free in Animation" exploit, which was discovered and reported by
Adam Weidemann and Clément Lecigne from Google's Threat Analysis Group.
In total, the latest update includes 11 security fixes, over half of which are deem High in severity. The listed bug bounties total $29,000, though the actual sum is higher—there are at least two bounties that are yet to be determined.
Google provided bare minimum details on most of them. They include...
High: CVE-2022-0603: Use after free in File Manager. Reported by Chaoyuan Peng (@ret2happy) on 2022-01-22
High: CVE-2022-0604: Heap buffer overflow in Tab Groups. Reported by Krace on 2021-11-24
High: CVE-2022-0605: Use after free in Webstore API. Reported by Thomas Orlita on 2022-01-13
High: CVE-2022-0606: Use after free in ANGLE. Reported by Cassidy Kim of Amber Security Lab, OPPO Mobile Telecommunications Corp. Ltd. on 2022-01-17
High: CVE-2022-0607: Use after free in GPU. Reported by 0x74960 on 2021-09-17
High: CVE-2022-0608: Integer overflow in Mojo. Reported by Sergei Glazunov of Google Project Zero on 2021-11-16
High: CVE-2022-0609: Use after free in Animation. Reported by Adam Weidemann and Clément Lecigne of Google's Threat Analysis Group on 2022-02-10
Medium: CVE-2022-0610: Inappropriate implementation in Gamepad API. Reported by Anonymous on 2022-01-08
Several of these are Use After Free bugs, which deal with memory corruption and are somewhat common among browser hacks. In this case, the UAF flaws affect File Manager, the Webstore API, ANGLE, GPU, and Animation, the latter of which Google confirmed an exploit for "exists in the wild." That's notable, given it's estimated there are at least 3.2 billion Chrome users.
You can wait for an automatic update, but given the situation, you're best off forcing the issue. That's easy enough to do. Just click the three vertical dots in the upper-right corner to bring up the Chrome Menu and navigate to Help > Google Chrome. The browser will then check for an update and, if available, begin downloading it right away. Once finished, you'll need to relaunch Chrome.
Tags: Chrome, Google, security, Browser, Zero Day, (nasdaq:goog)


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Food Monster App Tiny Rescue Shop Newsletter Support Us Cookbooks Petitions
The Great Cover-Up: Substitute Species in Illegal Wildlife Trade
By Aurora Luongo, Born Free USA Africa Policy & Capacity Building Program Associate
Lead Image Source : Vickey Chauhan/Shutterstock
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With a yearly value estimated between $7 and $23 billion, the illegal wildlife trade is a lucrative business that can quickly decimate targeted wildlife species. When trade regulations are strengthened for a particular wildlife product while the demand for that product remains high, traffickers are never short on stratagems to defy authorities and circumvent laws to continue meeting demand and selling illegal wildlife parts and products.
Traffickers will try to modify smuggling routes, lie on shipment declarations, falsify trade permits and licenses, and adapt their concealment techniques. In cases in which a species becomes extinct in one area because of overexploitation, they will look for other collection sites – within the same country or in another range state of the same species – or look for a substitute species to satisfy the demand. In most cases, the buyer is not even aware that a new species has been introduced.
The latest World Wildlife Crime Report, published in 2020 by the United Nations Office on Drugs and Crime (UNODC), states "this sort of species replacement is very common in wood markets, where even experts can struggle to distinguish between timber of related species." Rosewood species, which are in high demand for the confection of furniture in Asia, have paid a high price for this switch. The report highlights that "Pterocarpus erinaceus [African rosewood] itself has been exploited as an alternative to depleted Asian rosewoods," and then, when enforcement controls tightened for Pterocarpus erinaceus, other wood species in Africa were targeted as a replacement for trade.
Tiger Bones to Lion Bones
Source: MyAngelG/Flickr
The substitution of species in illegal trade is also having a significant impact on animal species. In its 2020 report, UNODC confirmed that in order to supply demand in China, where domestic trade in tiger parts is prohibited since 1993, traffickers replaced tiger bones with the bones of lions, jaguars, and leopards. Born Free played a key role in revealing the devastating impact that such substitutions can have on African lions. Findings from our 2018 report, Cash Before Conservation: An Overview of the Breeding of Lions for Hunting and Bone Trade, show that the trade in lion bones is threatening wild lions in Africa and wild tigers in Asia, as trafficking syndicates use lion bones as a substitute for tiger bones in expensive fortifying "wine" and other medicinal products in some East Asian communities, sometimes without the knowledge of users. The legal trade in captive-bred lion skeletons and bones may also be used as a cover by criminal syndicates to launder illegally obtained bones and skeletons from wild-caught animals, which is a major concern and one of the many reasons Born Free has campaigned to urgently stop lion farming and canned hunting. The May 2021 announcement by South Africa that the nation would reconsider the breeding of lions in captivity for trophy hunting or for tourists to pet, therefore, has very significant implications for the protection of wild lions across Africa, including in West Africa where lions are critically endangered and where Born Free runs wildlife law enforcement programs.
Pangolin Scales to Fish Skin
Arapaima scales have been used as a substitute for pangolin scales.
Source: Dirk Meyer/Wikimedia
Another example of substitution occurred when traffickers sought to replace pangolin skins with fish skin to satisfy insatiable market demand for exotic leather. Before 2000, the United States was a major importer of pangolin leather. As significant decreases in pangolin populations made pangolin skins harder to procure, importers started replacing pangolin skins with the skins of arapaima, the largest freshwater fish native to the basin of Amazon River, also threatened by international trade and listed in Appendix II of the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES).
Pangolins are the most trafficked mammals in the world. Before pangolins became overexploited in Africa, Asian pangolin species were decimated due to poaching and illegal trade, another example of traffickers adapting to changing conditions to keep their illegal trade going.
Elephant Ivory to Hornbill Ivory
The casque of helmeted hornbills has been used as a substitute for elephant ivory.
Source: Doug Janson/Wikimedia
When the substitute of a wildlife species targeted by poachers is a completely different species, but with similar characteristics, it can drive the substitute species to extinction.
The helmeted hornbill (Rhinoplax vigil) is a large bird found in the forests of Southeast Asia. It is adorned with a casque, a solid enlargement of the beak made of keratin. Poachers now hunt this bird for its casque, which is traded as "hornbill ivory" and serves as a current substitute for elephant ivory. But, the demand for this alternative is increasing in China, where it is carved for decoration and jewelry items, and the international trade in hornbill ivory has brought the helmeted hornbill to the brink of extinction. The species is now listed as critically endangered by IUCN and listed in CITES Appendix I.
Shark Fins to Sea Cucumbers
In the United States, shark fins also appear to have their substitutes in trade, particularly through the use of sea cucumbers (Holothuria) in soup. Both sharks and sea cucumbers are threatened by overfishing; 14 species of sharks and 3 species of sea cucumbers are currently listed in Appendix II of CITES.
The Path Ahead
The world is facing an extinction crisis, with more than 1 million species at risk of extinction, many within decades. Illegal wildlife trafficking plays a major role in the decline of wildlife species and biodiversity, but wildlife crime is a multi-billion dollar per year industry and traffickers have financial incentive to evade restrictions, including finding substitute species and products that can fulfill market demand. We must therefore respond to the problem of wildlife trade substitutions on two levels: decreasing demand and increasing law enforcement capacity.
The illegal trade in wildlife would not exist if demand for wildlife products did not exist. It is therefore important to invest in demand reduction initiatives, such as public awareness campaigns and education programs aimed at populations in destination countries.
We must also make investments to increase the capacity of law enforcement across source, transit, and destination countries so that officers are able to identify illegally trafficked species, make confiscations and arrests, and prevent more wildlife products from entering the market. Born Free USA's capacity-building program in West and Central Africa works to do exactly that – provide law enforcement officials, customs officers, and others on the front lines of the fight against wildlife crime with the training, knowledge, and resources they need to protect wildlife.
Staying a step ahead of wildlife traffickers is an ongoing challenge, but it is a challenge we can – and must – meet. But, we can only do it by working together. Please join Born Free USA in our fight to protect species and safeguard the natural world!
State Department Will Deny Visas to Known Wildlife Traffickers Trying to Enter the United States
New Report Show Millions of Species Illegally Trafficked from Brazilian Amazon
Write to Your Local Politicians to End Wildlife Trade Now!
How Coronavirus and the Wildlife Trade are Linked
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Home › Look At Her Eyes Quotes
Look At Her Eyes Quotes
Enjoy reading and share 45 famous quotes about Look At Her Eyes with everyone.
"Id met people in my life who were pure poison. I had learnt to know the look of them - the way their smiles came and went and never touched their eyes, those eyes that could be so intense at times and yet revealed no soul. Such people might look normal, but inside it was as though some vital part of them was missing, and whenever I saw eyes like that Id learnt to turn and run and guard my back while I was leaving."
— Susanna Kearsley —
"Ultimately - or at the limit - in order to see a photograph well, it is best to look away or close your eyes. 'The necessary condition for an image is sight,'Janouch told Kafka; and Kafka smiled and replied: 'We photograph things in order to drive them out of our minds. My stories are a way of shutting my eyes."
— Roland Barthes
"And suddenly, she stops moving and looks straight at me. "I'm in love with everything about you".
Her words make me suck in my breath, and when I look into her eyes, I see something I haven't noticed in a while-this look of pure understanding that reminds me why I told her my secret in the first place. That sense of wonder, how she looked at me like she couldn't know me well enough."
— Tamara Ireland Stone
"I look into your eyes to find the truth. In other dimensions, I found a portal which connects life, logic and nature. It feels the body with knowledge, inspiration, love, and an engraved library of wisdom.
Katia M. S."
— Katia M. S.
"Drake: "I know it;s love because I think of you night and day. I miss you when you are sitting right next to me. When I look at you my heart races and my stomach turns in the best and worst way possible. When I'm with you I feel complete, I feel whole. When I'm away from you it;s hard to breathe. When I think of my life without you I panic and tears fill my eyes. Before I met you, I didn't think I had much of a future besides being CEO at Baylor. I look at you, Morgan, and am filled with beautiful optimism at all of the things my future could have, and that is because i see you right there with me. I want to marry you, Morgan, I want to have children with you. You are my best friend, my confidant, my everything. To me that's love. You say you love me, Morgan, is that how you feel?" I ask hopefully.
"Yes," Morgan says, as a confident smile crosses her face and tears fill her eyes. "Yes, that is exactly how I feel. I love you, Drake, you are my everything,"
— L.K. Lewis
"I am very sorry, sir, but I cannot give you the Windsor crown," Rita said calmly. "I do not have it, and even if I did, it is not mine to give away."
"I don't know if you heard me correctly," the sergeant repeated, his words falling like bricks. "I said, hand it over."
Rita smiled serenely and stood, holding her thin hands clasped in front of her. Nora glanced up at her, a worried look in her eyes.
"Quite possibly it was you who did not understand my reply. I said, I am very sorry, but I am afraid I cannot give you the crown. But I can offer you a nice cup of tea, and I just baked a batch of cheddar scones."
A muffled snicker went through the room. I could even see Wesley, who stood by the door, trying not to smile."
— Galaxy Craze
"When we look into the eyes of others with compassion, our personal biases suddenly begin to fade away. Then, we can see others for what they truly are, Human."
— Rob Pinell
"It is lovely to meet an old person whose face is deeply lined, a face that has been deeply inhabited, to look in the eyes and find light there."
— John O'Donohue
"What do you want to talk about until the flight is called?"
"Cold wind. Sleet. The ugly doorman at Club 39. Porridge."
I burst out laughing. "You mean anything that won't give you an erection?"
He smiled at me, his eyes roaming my face lovingly. "Maybe we should just stop talking altogether. And put a bag over your head. And cover your legs."
"Just don't look at me."
"I can still smell you."
"I could move."
"Dare move away from me and I'll put you over my knee, Wife."
"That doesn't sound so bad."
— Samantha Young
"And you look like a protagonist." She was talking as fast as she could think. "You look like the person who wins in the end. You're so pretty, and so good. You have magic eyes," she whispered. "And you make me feel like a cannibal."
— Rainbow Rowell
"Hey," Cath said, rolling her eyes. She hadn't thought he'd seen her. "Look at you. All sweatered up. What are those, leg sweaters?" "They're leg warmers." "You're wearing at least four different kinds of sweater." "This is a scarf." "You look tarred and sweatered." "I get it," she said."
"Roses are red and violets are blue, That played-out shit isn't for you. I got your love letter right here in my eyes. If you look deep enough, you'll see through the lies."
— Wendy Higgins
"Baby, open your eyes and look around. We're all damned in one way or another. But damned is a far cry from dead. And you live like you are dead."
— Sherrilyn Kenyon
"He leaned over and gently kissed her cheek. Jessica smacked her lips, snorted a time or two, then dropped back off to sleep. "I love you," Richard whispered. "Sweet Jessie, I do." Only soft snores answered him. Richard smiled. He wished Jessica had been awake to see it, for he was certain it was a smile that would have pleased even her. More than just the corners of his mouth had joined in. He laid his head down next to hers and stared at her. He would sleep later. Now he would look his fill and see if he couldn't identify that expanding feeling in his chest that brought tears to his eyes. Could it be joy? He'd ask Jessica when she woke. After all, she knew all about it."
— Lynn Kurland
"I want to make love to you because I care about you. I want to worship your naked body with my own and learn all of your secrets. I want to please you, not for minutes, but for hours and even days. I want to see you arch your back in ecstasy and look into your eyes when I make you come."
— Sylvain Reynard
"Your eyes look like chocolate," I mumbled.
He smiled. "And yours look like the morning sky."
— Kiera Cass
"The sheer splendor of the sight made my chest tighten and tears sting my eyes. All the darkness lately made it easy to forget the world contained more than people trying to hurt other people. It had beauty, too, if you knew where to look
and remembered to open your eyes."
— Jeaniene Frost
"He's supposed to look out for you."
"I do!" Kieran sounded offended. "You should be proud of her. Hart requested her presence personally at the Drake coronation."
I closed my eyes briefly. We were doomed.
"You went to a vampire ceremony?" Grandpa asked evenly.
"He didn't know?" Kieran asked.
"No, he didn't."
Grandpa vibrated with rage. "I will not tolerate this kind of behavior in my family!"
"It's different now," Kieran tried to assuage him. "I'm dating Solange Drake. They're a good family."
Grandpa went red, then purple. Kieran took a step back. I whacked Grandpa between the shoulder blades.
"Grandpa, breathe!"
— Alyxandra Harvey
"Go to hell," he said, but there was a desolate fear in his eyes and I couldn't look away.
"Been there. Trust me. It's so overrated."
— Melina Marchetta
"I was immediately aware of her when she stood at the window but I didn't move at first. I wanted to look at her with my human eyes.#Ren"
— Colleen Houck
"It's beautiful to have people look me in the eyes and actually treat me like a human."
— Ellar Coltrane
"I'd met people in my life who were pure poison. I had learnt to know the look of them - the way their smiles came and went and never touched their eyes, those eyes that could be so intense at times and yet revealed no soul. Such people might look normal, but inside it was as though some vital part of them was missing, and whenever I saw eyes like that I'd learnt to turn and run and guard my back while I was leaving."
— Susanna Kearsley
"It must be a marvelous thing to feel so sure, to be able to meet someone's eyes and not look away."
— Shannon Hale
"Something was beyond wrong. Sebeck looked at the faces of the agents and police arrayed around him. There was abject hatred in their eyes. Burning anger. He knew that look. It was the look reserved for the vilest criminals. They were closing in from two directions-leaving a clear field of fire. Twenty or thirty heavily armed men. Sebeck glanced at Ross, who already had his hands on his head. "What the hell is going on, Jon?" "I don't know. But the Daemon's got something to do with it." "This is your last warning! Put your hands on your head, or we will open fire!" Sebeck felt his blood rising. He put his hands on the back of his head but looked to Ross. "Why are they looking at me?" "I don't know." The Feds hit Sebeck like linebackers. They"
— Daniel Suarez
"I love doing eyes - my signature look is a cat eye. I think it's so feminine, and it reminds me of old Hollywood."
— Mallory Jansen
"I am the god of dreams, but not even I would dream of speaking for Hades," Morpheus replied with a mischievous look in his eyes. "But if I had to guess, I would say it's because he knows how destructive his little brother is. Hades, unlike most of the other gods, cares for mortals and doesn't want to see them at war. Probably because he has to tend their souls when they die. He has had to judge millions of souls and that has given him a strong sense of justice. Leaving you to fight Zeus with no training is something he would consider unjust."
— Josephine Angelini
"It appears, from all this, that our eyes are uncertain. Two persons look at the same clock and there is a difference of two or three minutes in their reading of the time. One has a tendency to put back the hands, the other to advance them. Let us not too confidently try to play the part of the third person who wishes to set the first two aright; it may well happen that we are mistaken in turn. Besides, in our daily life, we have less need of certainty than of a certain approximation to certainty. Let us learn how to see, but without looking too closely at things and men: they look better from a distance."
— Rémy De Gourmont
"She loved the fine hairs on his chest. She loved the strength in his arms, the sound of his laughter, the way he would always look into her eyes and say her name."
— George R.R. Martin
"And the intolerant eyes which in the last two years had acquired that transparent film which the eyes of carnivorous animals have and from behind which they look at a world which no ruminant ever sees, perhaps dares to see, which I have seen before on the eyes of men who have killed too much, who have killed so much that never again as long as they live will they ever be alone."
— William Faulkner
"Some 'Terminator' fans are outraged that I'm playing Sarah Connor. They think I'm not muscly enough. To be honest, I'm a little tired of the comparisons to Linda Hamilton. I know she will always be the original Sarah Connor, but when people see what I bring to the role, they will look at her with new eyes."
— Lena Headey
"Education isn't what some people declare it to be, namely, putting knowledge into souls that lack it, like putting sight into blind eyes ... The power to learn is present in everyone's soul and ... the instrument with which each learns is like an eye that cannot be turned around from darkness to light without turning the whole body ... Then education is the craft concerned with doing this very thing, this turning around, and with how the soul can most easily and effectively be made to do it. it isn't the craft of putting sight into the soul. Education take for granted that sight is there but that it isn't turned the right way or looking where it ought to look, and it tries to redirect it appropriately."
— Plato
"Usually, when I've met the people who are meant to be in a position of power, I've always made sure to give them a damn good soul stare-y'know, look right in their eyes, through the blackness of the pupils and into whatever conscious field exists within. Then lock the eyes on, but let them gently defocus so that the defined parameters of the visual physical go blurry and you can feel the energy behind it, the unseeable energy that isn't made of photons. Then, if your mind is quiet, you will be informed of the quality of their essence, or at least of the manifest persona that they believe themselves to be."
— Russell Brand
"Capitalism is the way of the devil and exploitation. If you really want to look at things through the eyes of Jesus Christ
who I think was the first socialist
only socialism can really create a genuine society."
— Hugo Chavez
"I've never felt so much at once. I've never needed to feel more. I lift my head and look back down into her eyes. She's a part of me now. I'm a part of her. I kiss her softly on the nose ans mouth and chin, then press my ear against her heart again. For the first time in my life, I hear absolutely everything."
— Colleen Hoover
"I wait for a long time without anything changing. The room is still dark, the floor still cold and hard, my heart still beating faster than normal. I look down to check my watch and discover that it's on the wrong hand-I usually wear mine on my left, not my right, and my watchband isn't gray, it's black. Then I notice bristly hairs on my fingers that weren't there before. The calluses on my knuckles are gone. I look down, and I am wearing gray slacks and a gray shirt; I am thicker around the middle and thinner through the shoulders. I lift my eyes to a mirror that now stands in front of me. The face staring back at mine is Marcus's."
— Veronica Roth
"I already told you, I'm not gonna subscribe to your stupid magazine!' she yells.
'We're not selling anything,' Jake calls back. 'We just came to see my favorite chula this side of the Mississippi.'
The girl pauses and shields her eyes to get a better look. 'Jacob? That you?'
'In the flesh,' he confirms with a broad grin."
— Hannah Harrington
"Do you practice the laugh, or is it a natural talent? Naw, I'm betting you practice."
Jean-Claude's face twisted. I couldn't decide if he was trying not to laugh, or not to frown. Maybe both. I affected some people that way.
The laughter seeped out of her face, very human, until only her eyes sparkled. There was nothing funny about the look in those twinkling eyes. It was the sort of look a cat gives a small bird.
Her voice lifted at the end of each word, a Shirley Temple affectation. "You are either very brave, or very stupid."
"You really need at least one dimple to go with the laugh."
Jean-Claude said softly, "I'm betting on stupid."
— Laurell K. Hamilton
"I believe in empathy. I believe in the kind of empathy that is created through imagination and through intimate, personal relationships. I am a writer and a teacher, so much of my time is spent interpreting stories and connecting to other individuals. It is the urge to know more about ourselves and others that creates empathy. Through imagination and our desire for rapport, we transcend our limitations, freshen our eyes, and are able to look at ourselves and the world through a new and alternative lens."
— Azar Nafisi
"You who look at everything through your perpetually open eyes, is your lucidity never bathed in tears?"
— Michel Serres
"Move forward. Keep drawing myself. I will look at the world in the eyes and run forward."
— Minzy
"Whenever I get distracted or bored, my eyes wander over to that chalkboard and I read the words. Some of them grow on me, and others annoy me. I attack the latter with eraser and chalk, and keep nudging at them until I like the way they look and sound. Others never make the cut at all and simply get erased. Perhaps one day I will sell these on eBay to RPG players who need names for characters or alien races."
— Neal Stephenson
"I remember being with a girlfriend who asked me to look over some chess openings with her. I instantly fell asleep. I found that I could always take a nap in any situation by just looking at some opening variation - my eyes would shut right away."
— Pal Benko
"You got to look outside- your eyes- you got to think outside- your brain- you got to walk outside- your life- to where the neighborhoods change."
— Ani DiFranco
"His eyes are like a telescope. I look into them and I'm transported across the universe to a world I've never been."
— Julie Anne Peters
"I would give a lot to actually be able to glamour China into not wanting ivory. I can't even tell you how much I would give to be able to stop the illicit trade of Africa's wildlife, and to just look into the president of China's eyes and say, "You don't want this anymore, your country doesn't want this anymore," and have it be done. That would be great."
— Kristin Bauer Van Straten
"I look at my own body
With eyes no longer blind-
And I see that my own hands can make
The world that's in my mind."
— Langston Hughes
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Congratulations on completing your problem gambling specific training hours. You have taken the first step in the certification process, and we applaud your efforts and commitment to assisting those whose lives have been impacted by problematic gambling behavior.
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Home » Trump did not joke: the United States punished Erdogan for S-400
Trump did not joke: the United States punished Erdogan for S-400
Gasanov Kamran
The United States suspended Turkish pilots from training on F-35 fighter jets and demanded that they close the S-400 deal by the end of July. What measures will Donald Trump use if Turkey refuses to fulfill his demands, and does Recep Tayyip Erdogan have a "plan B"?
Two whip blows
So, on June 7 and. about. Pentagon chiefs Patrick Shanahan wrote a four-point letter to the Turkish Ministry of Defense.
If Turkey continues to implement the purchase of C-400, then:
The United States will exclude it from the program for the development of fifth-generation fighter F-35.
Turkey will not receive delivery of four prepaid F-35s.
From the end of July, Turkish pilots will be excluded from training on these fighters.
By July 31, all Turkish personnel involved in the production of the F-35 must leave the United States.
Washington's second attack was yesterday's statement by Pentagon press secretary Lieutenant Colonel Mike Andrews. He said that Turkish pilots at the US Air Force Base Luke in Arizona are no longer trained on the F-35.
The United States has warned Turkey since 2017 that it will impose sanctions if it does not break the deal with Russia signed in the same year. But Recep Tayyip Erdogan did not retreat. In a recent statement on June 4, he said that "there can be no question of taking a step back on the S-400 issue," and Turkey will execute the contract. Erdogan's obstinacy forced the Donald Trump administration to move from threats to actions.
In late May, Erdogan offered the United States a compromise option - to create a joint working group on S-400. However, the United States is satisfied with only one compromise - a complete rejection of the Russian air defense system.
Why does Washington resist buying the S-400?
There are a number of reasons for this:
Representatives of the United States and NATO argue that Russian air defense systems are incompatible with NATO systems and standards that the Turkish armed forces operate on.
The Pentagon fears that Russian specialists will learn the secrets of the F-35 fighter jets bought from the United States that are training the Turks operating the S-400.
The US military-industrial complex intends to impose its Patriot systems on Turkey.
The S-400 deal will make Ankara more independent of Washington and bring it closer to the adversary of NATO, Moscow.
The transition from unofficial threats to official ones is justified by "deadlines". The first batch of S-400 air defense systems will be delivered to Turkey in July this year. On May 22, Turkey sent military personnel to Russia to train the S-400 command and control system.
In late July, Trump and Erdogan are sent to the G20 summit in Osaka, Japan. If the Pentagon remains faithful to its ultimatum, then the rendezvous at the G20 is the last chance for the presidents to save the relationship. If they do not agree, the United States will have to impose sanctions.
"Blow to the Turkish economy"
There should be no doubt in Trump's readiness for sanctions. In the summer, he had already resorted to this instrument and brought down the lyre for the sake of the release from Turkish prison of pastor Andrew Brunson, accused of Erdogan in collusion with the Gulenists.
Turkish politicians and ruling parties discuss how to avoid sanctions every day. In 1964, the United States sent the same threatening letter to Ankara, and then an economic crisis began in Turkey. Turkey is now experiencing serious economic problems. Two years ago, the dollar was worth 2.5 lira, and now - six. Unemployment rose to 13 percent - that's five million people. Most of them are young people.
The main danger of US sanctions is the possible accession of the EU countries to them.
Does Erdogan have a "plan B"?
Even if the EU does not join them, the US sanctions will still cause damage to the Turkish economy and will undermine Erdogan's rating. Far from the next presidential elections, they will be held in 2023. However, external forces will use public discontent to overthrow the Turkish president.
The last such attempt in 2016 failed, and the new one would be more risky for the United States. Further pressure on Turkey may give a completely different result. Erdogan can convince the Turks that the main reason for their poverty is US attacks. The continuation of the crisis will force Ankara to look for an alternative - both military-political and economic. In the first case, you need to talk about Russia, in the second - about China.
With all the desire to punish rebellious Turkey for the United States, it is preferable to keep her in NATO than to lose influence on one of the main conductors of their interests in the Middle East.
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Namaskar, every person of India at the age of 18 or above can vote in elections. The minimum age for having voter ID card is 18 decided by Goverment of India. The person should have his/her voter ID card to give vote in election. If you don't have voter ID card. Click below post link and see how to get new voter id card online and offline. Click on it.
How to Apply For Election Card Online ?
Voter list is updated every year. New names are added. Some are deleted. Some areas are added. So we have to stay updated to this voter system. Here, we will talking about how to search your name in voter list in Gujarat.There are two methods for finding your name in voter list in Gujarat. Two methods are mentioned as below.
2. Search By ID Card No.
Lets learn this in detail with step by step information.
Enter your Surname, Name, Father's name and Age. Select your gender.
Enter captcha code in box from another box.
Click on search button. You can select English or Gujarati from below that.
Your details will come. Click on more details for your BLO officer detail & details of members of your family.
Now, tick on 'Search By ID Card No.' and select it.
Enter your election card number. This number is on your election card.
This is the simple step by step tutorial to search your name in voter list Gujarat.