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The 1997 Bloc Québécois leadership election was the leadership election that picked the new leader to replace Michel Gauthier as leader. The leadership election was conducted by a one member, one vote (OMOV) process involving all party members.  Voters were asked to list their first, second and third choices on the ballot. Bloc MP Gilles Duceppe won the leadership election.

Timeline
February 17, 1996: Michel Gauthier became leader of the Bloc Québécois.
March 15, 1997: Gilles Duceppe won the leadership election on the 2nd ballot.

Candidates

Result

Sources

1997
1997 elections in Canada
1997 in Quebec
Bloc Québécois leadership election

redpajama_set_name: RedPajamaWikipedia


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Madness of Crowds: Google's 'lucky seven' maddened crowds
It's difficult, simply sitting alone in a small room in south London, really to get a feel for how mass human behaviour is affecting the world. But it's too cold in late February to go out much, and besides, by this point in winter, my sense of autonomy has been so savagely eroded that I fear for what little sense of individuality I have – if I stand next to as few as two others I can sense myself being sucked into a maelstrom of the masses. So, this week, I have decided to trust to algorithms rather than observation and I offer you the top "lucky seven" maddened crowds as compiled on our behalf by Google News. It took 0.53 seconds for the HMRC-compliant search engine to come up with a humongous crowd of 91,600,000 results – so I hope you're grateful I'm not doing the entire countdown.
OK, that's right! Sit tight! In at number seven is someone called Adele; I'd never heard of her before, but apparently she's a popular crooner. Anyway, this Adele woman performed a concert on 12 February in Los Angeles, and the "historic" Wiltern theatre was stacked with some 2,300 fans who, it seems, "knew the words of every song". Adele charmed them all, remarking that she felt so hot, "I feel like my make-up's about to slide off me face!" But the true insanity ensued when she revealed that it was at her own insistence that the ticket price had been held at $50. According to the Yahoo Music website, this drew "thunderous applause". Of course it did! I remember attending a Martha Argerich recital at the Wigmore Hall where her ethereal rendition of Bach's partitas was entirely drowned out by the drumming of elderly, bunion-ridden feet, as we noisily protested at having to pay over the odds.
A new entry at number six are the crowds who, crazed by Promethean scientific advance, flocked to the Laser Interferometer Gravitational-Wave Observatory (LIGO) near Hanford, Washington State, after it was announced that scientists there had detected the existence of the gravitational waves predicted by Einstein. Setting to one side the observation that there was absolutely nothing to see at all, we can still marvel at their marvelling.
Annette Cary reported in the Tri-City Herald that Jason Jones of Seattle had driven 200 miles to visit the observatory. "I'm in awe of the science that happened in this place," he told Cary. "It could fundamentally change our view of reality." This may be true, although so far it hasn't had any effect on people nonsensically massing.
Number five is an old favourite that's perennially re-released – a sports crowd kicking off. In this case, they were Corsican, so naturally they took their anger outside the ground, and to a . . . police station. About a hundred hardcore Bastia fans launched the attack, which followed another of their number being injured in a scuffle with police during Saturday's away match in Rheims. I, for one, think this widening of footie fracas is a heartening development – perhaps West Ham's so-called fans can take on the so-called Islamic State?
At number four is another crowd they might cheerfully lay into: the estimated 230,000 people who attended the National Multicultural Festival in Canberra over the weekend. Given that Canberra is a distinctly white and triumphantly dull city, this hardly surprises – last year 73 local people were killed attending the opening of a Tetra Pak carton.
Still, all power to those ockers – they've come a long way since they granted their own indigenous people citizenship in 1968, to embrace multiculturalism by keeping refugees in concentration camps.
Number three are the police in the Indian state of Haryana who've abandoned their rubber bullets and water cannon, and taken to subduing angry mobs with "specially designed" and locally manufactured slingshots that fire plastic balls full of chilli powder. But lest we imagine these followers of the Mahatma are becoming too non-violent, they've said they'll catapult marbles if the chilli powder doesn't work.
At number two is the ageing meerkat lookalike and tedious "raconteur" Garrison Keillor, who apparently addressed a crowd of more than 2,000 the other afternoon at the Holland Centre in Omaha, Nebraska. They were febrile to begin with but Keillor's signature monotony soon pacified them, and several elderly audience members died when their hearts skipped too many beats. They should get out less.
And finally, at number one – for now, then, and for all eternity! Yes! That's right! Sit tight! It's the Supreme Father, His Holiness Pope Francis, who addressed a vast crowd in the Mexico City suburb of Ecatepec. Numbering around a third of a million, the flock of faithful was shepherded by some 10,000 armed police. The Pope told the adoring crowd: "With the devil, there is no dialogue . . . although I'm reliably informed he has the best tunes," a reference to the drug-fuelled violence that has made Ecatepec one of the most dangerous 'hoods in the world – especially if you're a woman. And if you're a Mexican woman living in terror from a bunch of super-violent misogynistic bastards, where better to seek succour than from a cross-dressing celibate who hears voices?

redpajama_set_name: RedPajamaCommonCrawl


Nonino is the Italian family company famed for its grappa, and grappa is the base of this amaro, made in Friuli. This is also aged in barrel for 5 years. Look for a bittersweet balance, from cinchona and gentian, rhubarb, saffron, sweet and bitter oranges. Lovely package, and a perfect digestif.


For some children, change is an adventure while for others change brings anxiety and restless nights.
One simple way you can build a feeling of positive connection in your child is by 'wrapping them in a rainbow' at night before they go to sleep. This ritual instils a sense of loving connection and safety – connecting them heart-to-heart to the people they care about with a rainbow.
Using this ritual every night in the lead up to the start of school will help children feel a sense of loving connection.
This ritual has been used by tens of thousands of families for many different purposes to instil a sense of loving connection and safety. It puts an end to nightmares and helps with sleep, anxiety or feelings of fretting children may feel when separated from parents and siblings when starting school.
One of the great benefits of wrapping children in a rainbow is having the opportunity to ask them where they would like to send a rainbow before they go to sleep. This lets them share something about their worry or concern. They can send a rainbow to a relative or friend who might be unwell or to a parent who might not live with them.
Sending rainbows is a way for children to feel they've made a positive contribution rather than feeling helpless in upsetting situations.
When a child is ready for sleep, ask them to snuggle down into a comfortable position so that you can wrap them up in a rainbow. You can ask the child to close their eyes so that they can imagine better.
Running your hand lightly over the whole of their body, from the top of their head to the tips of their toes, ask the child to imagine that you're wrapping them up in a cloud of red – the colour of tomatoes and fire engines.
You can ask the child if they can see the colour – children can always visualise colours.
Next, still running your hand lightly over their body, you ask the child to imagine that you're wrapping them up in a cloud of orange – the colour of oranges, marigolds and nasturtiums.
Next, you wrap them in a cloud of yellow – the colour of wattle, daffodils and golden warm sunshine on a bright sunny day.
Then the colour green – the colour of spring leaves and new mown grass. All the while running your hand lightly over the body of the child.
Next you wrap the child in the colour of blue – the colour of the clear blue sky on a sun filled day or the colour of the ocean. You can ask the child again if they're able to see the colours.
Then the colour of indigo – the colour of the night sky behind the stars.
Then you wrap the child in the colour violet – the colour of little sweet-smelling violets peeping out amongst the flowers in the garden.
Finally, place your hand over the child's heart and get them to visualise as strongly as they can a rainbow that starts in their heart and that comes out through the air and connects with your heart (placing your hand over your heart). Tell the child that this rainbow keeps the two of you connected all through the night.
I wrap you in a rainbow of light to care for you all through the night. Your guardian angel watches from above and showers you with her great love.
After connecting up by rainbow with you, the child might like to send rainbows to loved ones or friends in need of love or support. They can send them to people they're separated from by distance, divorce, illness or death. Children can be wrapped in rainbows before they're separated from you for any reason – beginning pre or primary school, leaving for camp, staying with friends or grandparents.
When passing a car accident, instead of becoming distressed about it, instead visualise that you're all under one end of a rainbow breathing in the iridescent colour and peace of the rainbow then extend the other end of the rainbow to those in need.
Imagine your love and blessings flowing over the rainbow, like fairy dust, bringing peace and calmness so that what needs to get done gets done quietly and efficiently.
Rainbows can be sent to those affected by floods, disasters or other distressing situations which often leave children (and ourselves) feeling helpless. They can be sent between family members if someone is feeling sooky, sick or overwhelmed. They can be sent for exams, medical tests or treatments.
Don't be surprised to see rainbows appear in a clear blue sky, outside a hospital window or in totally unexpected places.
Please contact us at the Quest for Life Centre if we can be of any assistance to yourself or a member of your family or if you need a rainbow sent to someone you love or yourself.


With a boat, you don't need a week—or even a weekend—to escape the every day. A few hours on the water makes a great getaway—and rentals or charters can get you on the water today!
Answer a few questions with our boat selector tool and you will be one step closer to your dream boat.
Why limit your vacation to once a year? Get a boat and get away whenever you want all season long. Discover the fun, freedom and flexibility of owning a boat.
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Boat trips are just plain good for the soul. Whether you're looking for community or escape, adventure or tranquility, boating offers endless ways to explore a world away from land.
If you're trying to decide between a new and pre-owned boat, we've done most of the heavy lifting for you. Explore your options here.


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Baskin-Robbins Grows into Plant-Based Category with Non-Dairy Flavors
July 25, 2019 by Nevistas News
Baskin-Robbins Non-Dairy Chocolate Chip Cookie Dough and Non-Dairy Chocolate Extreme
Baskin-Robbins is dipping into the plant-based dessert category with the launch of two new non-dairy flavors. Both Non-Dairy Chocolate Chip Cookie Dough and Non-Dairy Chocolate Extreme will be available for ice cream fans in-store beginning August 1.
Baskin-Robbins launches Non-Dairy Chocolate Chip Cookie Dough and Non-Dairy Chocolate Extreme, options for guests looking for vegan options.
The two non-dairy – yet flavor-full – menu items are vegan* takes on classic fan-favorites. Made with a base blend of coconut oil and almond butter, the result is a dessert so rich and indulgent, you won't be able to tell that it's not the full-dairy version:
Non-Dairy Chocolate Chip Cookie Dough is made with cookie dough pieces, chocolate chunks and a chocolate ribbon.
Non-Dairy Chocolate Extreme contains chocolate chunks and a chocolate ribbon, and is also gluten conscious.**
Both flavors contain no artificial dyes, which have been absent from all Baskin-Robbins ice cream since 2017 as part of Baskin-Robbins' and Dunkin' Brands' commitment to serving high-quality menu items. The Non-Dairy flavors are also free from preservatives, artificial flavors, high fructose corn syrup, and are Kosher.
"The Baskin-Robbins culinary team has been hard at work on our non-dairy flavors for over two years. It was important for us to take the time to get it right," said Jeanne Bolger, Director of Research and Development, Baskin-Robbins. "Both flavors are so smooth and indulgent, and the final product delivers the incredible quality that our customers have come to expect from any Baskin-Robbins ice cream. We're very proud of the result."
With plant-based food sales increasing in double-digits across the country1, Baskin-Robbins embraced the opportunity to expand their ice cream portfolio to non-dairy indulgences.
"We're excited to expand our ice cream portfolio into the vegan space and offer our guests increased options, especially with such high consumer demand for a product like this," said Carol Austin, Vice President of Marketing for Baskin-Robbins.
HMSHost Inks Exclusive Deal with Panera Bread to Bring Bakery-Cafes to U.S. Travelers
Yum! Brands Appoints Taco Bell Division and Pizza Hut Division Chief Executive Officers to Drive Global Brand Strategies and Growth


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Slovac (Servisch cyrillisch: ) is een plaats in de Servische gemeente Lajkovac. De plaats telt 307 inwoners (2002).

Plaats in Servië


Here are some of our favorite jokes about Nebraska's biggest rivals.
• What do you call a Golden Gopher in a BCS bowl game?
• What's the difference between an Iowa football player and a dollar?
• What do you get when you cross Minnesota with a groundhog?
• Where was O.J. headed in the white Bronco?
Michigan State. He knew that the police would never look there for a Heisman Trophy winner.
• Did you hear that Minnesota's football team doesn't have a website?
The Gophers can't string three "Ws" together.
• What do Ohio State fans use for birth control?
• Why don't Minnesota fans eat barbecue beans?
Because they keep falling through the holes in the grill.
You've ever climbed a water tower with a bucket of paint to defend your sister's honor.
• The Foo Fighters are playing at Ryan Field this fall.


Ask a question about 3758 Eagle Hammock Dr, or schedule a tour.
Bank Owned Property in magnificent condition in the Hammocks Neighborhood. One of the best priced properties in the area Will not last long at this price.


within the middle of the next week.
> try to update to the current driver and re-test.
the missing key repeat functionality that Thierry added in June.
This should help to get the irrecord running again.
Could you check what is the firmware version in your device ?
newer 1.08 seems to be a little bit better in stability.
it should work quite fine.


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What it is: Biotweeps is a curated Twitter account — @biotweeps — featuring a different biologist every week. The project is organised by Anthony Caravaggi (http://www.arcaravaggi.co.uk) and Carina Gsottbauer.
Tip: Check the schedule to see which scientists will be featured in the future.


To think I've lived 30 years of my life and never noticed that Christian Lacroix designed furniture with their Maison Christian Lacroix. I'm literally picking my jaw up off the floor! Designed in collaboration with Roche Bobois Paris, the Atelier designs pieces that includes cabinetry, tables & chairs with traditional Parisian flair.
The latest line of home decor gives a nod to the French Art de Vivre, Maison Christian Lacroix has expanded its exclusive collection for Roche Bobois with the new collection now adds sofas and ottomans upholsetered in dark velvet.
MAISON LACROIX OTTOMAN (above) -Structure in solid beech, tenon and mortise assembly. Back in HR foam. Seat in HR foam on elastic straps.
MAISON LACROIX SOFA (above) – Upholstered in Cabaret velvet. Contrasting piping. Seat cushions with removable covers, HR foam 40kg/m³. Structure in solid wood and plywood. Cross-webbing elastic straps suspension. Available in other dimensions, armchair (below).
MAISON LACROIX SCREEN – Double-sided screen. 6 panels with hinges, top and edges in stainless steel with Onyx finish. Structure in 25mm-thick plywood. Digital printings of "Birds Sinfonia" on one side and "Groussay" on the other. Also available in another dimensions.
MAISON LACROIX COCKTAIL TABLES – Fixed top in lacquered plywood with digital print and round 4mm-thick extra-clear glass. Structure in solid Acacia wood, outline of top, braces and legs in stainless steel, Onyx finish. Available in another finish.


pollution and other characteristics determine its wide range of application space.
decorative paint will be less of the backbone of the.
flammable solvents can not be overcome.
operator's own physical and mental health.
rest of the powder can be recycled two times, the utilization rate of 98% - 90%.
costs; powder coating construction process, it is not required such a diluent.
and soft, to paint liquid coating after curing the appearance of dust.
is easy to generate pinhole and bubbles.
leakage and volatile, and may even burn the explosion.


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Green Globe / Europe / Inspira Santa Marta Hotel: Doing it Right, Globally & Locally
Inspira Santa Marta Hotel: Doing it Right, Globally & Locally
February 14, 2018 Bradley Cox
Inspira Santa Marta Hotel leads Lisbon for sustainable luxury. Built to be an exemplar of green design, Inspira Hotel counts itself as one of Green Globe's elite Gold Members and holds the highest certification compliance score in Portugal.
Inspira General-Director Tiago Pereira, says, "Doing the right thing is the motto guiding everything we do at Inspira, it is the concept that defines it. Around it we have combined the three fundamental pillars of our identity: environmental sustainability, social responsibility and sustainable development.
"As we ponder over the future of the hotel industry, we are forced to reflect upon the premise of our true conviction. We believe, on a global scale, that within the development of our industry there will inevitably be a greater adoption of more sustainable practices. It is natural that more responsible and conscious tourism will be pursued when it comes to resource management," added General Director Pereira.
Inspira seeks to offer its guests a unique experience in an ecologically sustainable hotel. The hotel's policy of responsibility, including sustainability as one of its core values, applies to all aspects of business ranging from the use of environmentally friendly materials, paperless systems and even gastronomic concepts, amongst others. At the same time Inspira's management policies and values are geared toward reduction, as this is the fundamental way to minimize the environmental impact of business and really make a difference.
Inside the stylish walls of the hotel, employees directly participate in environmental management via their roles in the Green Squad. Representatives from each department are encouraged to monitor and measure the progress of the property's sustainable actions, ensuring their continuous improvement via reports to monthly meetings.
Another significant commitment Inspira has taken on is the reduction of its carbon footprint. The certificate of CarbonFree emissions compensation (Ecoprogresso) includes direct and indirect greenhouse gas emissions related to the hotel activity. The carbon dioxide equivalent (CO2e ) of 164t of emissions was neutralized with the support of a national project, Sown Biodiverse Pastures Project – Biodiverse Pastures for Climate Change Mitigation and Soil Protection. The project promotes the sustainability of agriculture and the mitigation of environmental impact by via improved farming practices.
At Inspira, the quest for a more sustainable world also means involving the community in pursuing social goals that look to the common good. The hotel has always undertaken an active role in citizenship education and in the promotion of the principles of equality, diversity and respect. Supporting communities is part of Inspira's identity and the dedication of its employees allows connection to projects and initiatives of great relevance.
On an international stage, Inspira's partnership with non-governmental organization Pump Aid assists by installing drinking water pumps in developing communities. Inspira sponsors this project using the revenue generated from selling recycled glass bottles with filtered water that is bottled on site.
Locally, partnerships and protocols have been established with several social-good institutions whose projects provide shelter and assist people in different vulnerable conditions. These partnership include: Fundação Rui Osório de Castro and APPDA – Lisboa.
As a result of the partnership with APPDA Lisbon, Inspira has officially became one of the few places selling objects created by APPDA members. The ceramic or recycled pieces are handmade with a price range between €2 and €15, and all funds are reverted to the institution. The Association's purpose is to provide services to people with autism spectrum disorders (ASD) and their close relatives.
The Fundação Rui Osório de Castro is a local NGO founded with the aim of informing and enlightening parents, children and friends about issues related to paediatric oncology. The organisation helps all to better accept and live with the disease, while contributing to the development of scientific research in this area. Inspira retails the organisation's mascot Xi-coração, with all revenues donated to the institution.
The Inspira Santa Marta Hotel has always been a clear supporter of local economy and commerce, always preferring products developed in compliance with high ethical criteria and sustainably produced. Last year a kitchen garden was also built on the hotel roof top with different spices grown for use in the hotel's restaurant, which is a strong supporter of the Zero Waste Movement.
Inspira's staff and management also directly participate with volunteering programs. Last year a team of Inspira's employees visited Sintra-Cascais Natural Park to assist with biodiversity conservation. Employees also delivered food to the homeless people with Centro de Apio ao Sem Abrigo – CASA. The food was obtained through revenue raised from the Hotel's Open Restaurant during Christmas. And on top of that, hotel management and staff also found time last year, to put aside a few minutes of their day to donate blood at the Lisbon Blood and Transplantation Center.
General-Director Tiago Pereira, concludes: "All these initiative are super positive and different, and what I feel is that we give away a few minutes of our life, but that may mean a lifetime to others who are in need. These are small gestures that change the lives of many people and enrich those who give."
Margarida Gonçalves
Sustainability Project Coordinator
Inspira Santa Marta Hotel
R. de Santa Marta 48,
email: margarida.gonçalves@inspirahotels.com
http://www.inspirahotels.com
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HomeEnergy & SustainabilityADGM's Abu Dhabi sustainable finance forum charts path to COP28
ADGM's Abu Dhabi sustainable finance forum charts path to COP28
Aspiration, a multibillion-dollar fintech company, announced UAE expansion
ADGM
Abu Dhabi Global Market (ADGM), the leading international financial center of the UAE's capital city successfully concluded the fifth edition of the Abu Dhabi Sustainable Finance Forum (ADSFF) today. As a part of Abu Dhabi's week-long event, Abu Dhabi Sustainability Week (ADSW), ADSFF's agenda focussed on 'Charting the path to COP28,' as the nation prepares to host the global event later this year.
Convening top private market investors, government leaders, regulators, innovators, and financial institutions, ADSFF discussed areas of collaboration to increase the flow of capital towards sustainable investments and transition finance ahead of COP28. The overarching themes of the event revolved around nature-based carbon credits, concrete sustainable finance transactions, and products along with new ways to mobilize sustainable finance through start-ups, accelerators, and platforms based within ADGM.
The various sessions and panel discussions spread across the day used these themes as pillars of discussion to deep dive into topics such as the green falcon economy, global carbon market and carbon credits, innovative paths across finance and investment, views on the state of climate finance and the role of banks and other financial institutions in financing the net zero efforts and initiatives and much more.
Read: World Future Energy Summit to provide a "crucial sustainability blueprint"
Speaking at ADSFF Her Highness Sheikha Shamma bint Sultan bin Khalifa Al Nahyan, President and CEO of UAE Independent Climate Change Accelerators (UICCA), reinforced Abu Dhabi's commitment to a sustainable future. Sharing her views on the role of COP28 as a driver for policies and plans that facilitates global cooperation, she highlighted the urgency for climate action and emphasized the role of blended finance as a vehicle for collaborative sustainable investments
Mohamed Jameel Al Ramahi, CEO of Masdar, spoke about the key outcomes of ADSW and announced a pivotal year ahead as it intends to issue its first-ever green bond in 2023, allowing international investors to participate in Masdar's growth journey.
The session on the Green Falcon Economy by Issam Abousleiman, GCC Director, World Bank threw light on the adoption of a 'Green Growth Strategy' in the GCC that aims to grow GDP from USD 2 trillion in 2022 to more than USD 13 trillion in 2050 and was one of the highlights of the event. Speaking on behalf of the Green Climate Fund (GCF), the largest global fund dedicated to reducing greenhouse gas emissions in developing countries, Hong-Thuy Paterson, CFO and COO of the world's largest climate fund, GCF shared views on the state of climate finance, its landscape and architecture and vision for the year ahead. Insights on innovative finance and sustainable investment were shared by Hiro Mizuno the former UN Secretary General's Special Envoy on Innovative Finance and Sustainable Investment and a board member of Tesla.
Commenting on the successful conclusion of ADSFF, Emmanuel Givanakis, CEO of ADGM Financial Services Regulatory Authority (FSRA) at ADGM said, "The fifth edition of Abu Dhabi Sustainable Finance Forum is a vital step in 2023 as we align our strategies with the goals of COP28 to be held in the UAE this year. It is an ideal platform to gather both regional and global industry experts and thought leaders to pave the path leading to COP28, helping to unleash the trillions of dollars in private finance that are needed to power us towards net zero by the middle of the century."
"It is ADGM and FSRA's commitment to accelerate sustainable financing, along with addressing climate change and sustainability concerns that affect the financial sector, the economy, and the long-term well-being of the UAE. We remain dedicated and focused on the UAE's various strategic initiatives especially the Net Zero by 2050 targets and continue to heighten our efforts to support Abu Dhabi to not just build a falcon economy but a green falcon economy that is fully invested in the UAE's sustainable future."
During the forum, ADGM's Sustainable Finance Declaration welcomed 37 new signatories in its fifth round bringing the total number of members to 117. A special signing ceremony was conducted with all signatories to solidify their commitment toward climate action and sustainability. The event also witnessed the announcement of expansion plans in the UAE for 'Aspiration', a multibillion-dollar fintech company backed by Hollywood icons including Leonardo DiCaprio and Robert Downey Jr by setting up offices in the international financial center of ADGM. Aspiration is a purpose-driven climate action company that offers large and small enterprises, governments, investors, and consumers access to a portfolio of high-quality carbon assets through innovative products, services, and investments driving sustainability.
The ADSFF is a goal-oriented and collective effort by the UAE's financial sector to advance sustainable finance and investment of projects and initiatives that augment the country's national climate goals and ambition towards a better and more sustainable future. Approximately 1000 attendees including speakers and participants attended the event this year, making it one of the key sustainability events in the region ahead of COP28 in 2023.
For more on sustainability, click here.
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Nimotuzumab in Non-Small Cell Lung Cancer (NSCLC) of inoperable stage III epidermoid histology, concomitant with Chemo and Radiotherapy (CRT)
Acronym of Public Title:
Nimotuzumab in NSCLC
Phase II-III clinical trial, controlled, randomized, in parallel, adaptive design in two stages, compared, in patients with inoperable stage III epidermoid histology NSCLC, treated with concurrent CT-RT plus Nimotuzumab vs concurrent CT-RT.
Acronym of Scientific Title:
Nimotuzumab in NSCLC concomitant with CRT
Center of Molecular Immunology (CIM)
Center of Molecular Immunology (CIM) Cuban Ministry of Public Health (MINSAP)
Center for State Control of Drugs, Medical Devices and Equipment (CECMED)
Camacho Sosa
First degree specialist in Oncology.
University Clinical Surgical Hospital Commander Faustino Perez Hernandez.
Carretera Central Km. 101.
kireniac.mtz@infomed.sld.cu
Pinar del Rio, Provincial Surgical Clinical Hospital III Congress, Barbara Iglesias Castillo, MD, Second Degree Specialist in Oncology.
University Clinical Surgical Hospital Commander Faustino Perez Hernandez, June 11, 2018
Provincial Surgical Clinical Hospital III Congress, July 4th, 2018
Non-Small Cell Lung Cancer (NSCLC) stage III inoperable
Carcinoma, Non-Small-Cell Lung
Carcinoma, Bronchogenic
Bronchial Neoplasms
Lung Neoplasms
Respiratory Tract Neoplasms
Thoracic Neoplasms
Respiratory Tract Diseases
First stage: It will be compound by one group of treatment Group I Nimotuzumab+Chemotherapy+Radiotherapy (experimental): Nimotuzumab 200 mg by intravenous route, diluted in 250 mL of 0.9% saline solution, once a week for 20 weeks, followed by administrations every 14 days until up to 24 months after start the treatment. The Chemotherapy by intravenous route will be compound by Cisplatin (50mg / m2) plus 500 ml of 0.9% saline (days 1, 8, 29,36) and, Etoposide (50mg / m2) plus 500ml 0.9% saline solution (days 1 to 5 and from 29 to 33). The thoracic radiotherapy (60 Gy) will be receive 2 Gy daily, 5 times a week for 6 weeks. Second stage: It will be compound by two group of treatments Group I Nimotuzumab+Chemotherapy+Radiotherapy (experimental): Nimotuzumab 200 mg by intravenous route, diluted in 250 mL of 0.9% saline solution, once a week for 20 weeks, followed by administrations every 14 days until up to 24 months after start the treatment. The Chemotherapy by intravenous route will be compound by Cisplatin (50mg / m2) plus 500 ml of 0.9% saline (days 1, 8, 29,36) and, Etoposide (50mg / m2) plus 500ml 0.9% saline solution (days 1 to 5 and from 29 to 33). The thoracic radiotherapy (60 Gy) will be receive 2 Gy daily, 5 times a week for 6 weeks. Group II Placebo+Chemotherapy+Radiotherapy (control): Scheme same to the group I, using placebo instead of Nimotuzumab
Antibodies, Monoclonal, Humanized
Antibodies, Monoclonal
Drug Therapy
Chemoradiotherapy
Administration, Intravenous
Placebos
Nimotuzumab
Overall Survival (Time from randomization until death from any cause). Measurement time: until 24 months.
1. Quality of life (EORTC QLQ-C30 (v. 3) questionnaire). Measurement time: At baseline, 3, 6, 9, 12, 15, 18, 21 and 24 months. 2.Adverse events-AE (Description of AE (Name of the AE); Intensity of the AE (Mild, Moderate, Severe, Life-threatening consequences, Death); Seriousness of the AE (Serious, Not serious); Causality relationship (Very probable, Probable, Possible, Improbable, Not related, Not evaluable); Attitude towards treatment (Temporary interruption, Definitive interruption, Modification of doses, No change), Result of AE (Reversible effect, Irreversible effect, Death, Loss of follow-up)). Measurement time: until 24 months. 3. Antitumor response (It will be classified in Complete response, Partial response, Stable disease, Progressive disease according to RECIST criteria). Measurement time: At baseline, 3, 6, 9, 12, 15, 18, 21 and 24 months. 4. EGF concentrations: (Values in pico grams using serum levels through an ELISA). Measurement time: at baseline, 3, 6, 9 and 12 months. 5. Values of platelet count (Absolute values from serum measurements). Measurement time: at baseline, 3, 6, 9 and 12 months. 6. Progression-Free Survival (Time from treatment start until objective tumor progression or death from any cause). Measurement time: until 24 months.
Male/Female
1. Patients who meet the diagnostic criteria. 2. Patients with age greater than or equal to 18 years. 3. Patients who have signed the informed consent for the investigation 4. Patients with functional capacity according to ECOG from 0 to 1. 5. Virgin patients of oncospecific treatment. 6. Patients with life expectancy of more than six months. 7. Patients with normal hepatic, renal and hematologic functions defined by: • Hemoglobin greater than and equal to 90 g / L (patients with lower Hb levels should be transfused prior to inclusion) • Total Leukocyte count greater than and equal to 3.0 x 109 / L • Absolute Neutrophil count greater than and equal to 1.5 x 109 / L • Absolute Eosinophil count with any value. • Concentrations of EGF with any value. • Platelet count greater and equal 100 x 109 / L • Bilirubin up to the normal upper limit. • TGP and TGO: up to and less than 1.5 times the upper limit for the normal value of the institution, or <5 times the upper limit for the normal value of the institution, if the existence of liver metastasis is known. • Alkaline phosphatase greater than and equal to 2.5 times the upper normal limit. • Creatinine: Within normal limits for each institution or creatinine clearance> 50 mL / min / 1.73 m2 for patients with creatinine levels above the normal value of the institution.
1. Patients who have previously received onco-specific treatment. 2. Patients with acute, chronic, or inflammatory decompensated infectious diseases. 3. Patients of childbearing age who do not accept to use adequate contraceptive methods (intrauterine devices, barrier or tubal ligation methods, hormonal methods). 4. Pregnant or lactating patients. 5. Patients with acute allergic states or history of severe allergic reactions. 6. Patients that are not tributaries of receiving onco-specific treatment. 7. Patients with Brain Metastases.
Stage 1 (20 patients), Stage 2 (904 patients, 452 per group)
Ramos-Suzarte
PhD in Medicine. Biochemestry and Clinical Trials Specialistand. Nimotuzumab Project Manager
216 and 15. Atabey
mayra@cim.sld.cu


My review of the Sigma 35mm f/1.4 DG HSM now includes a page of field examples shot on the Canon 5D Mark III, with an emphasis on f/1.4, but also stopped down to a variety of other apertures.
The Sigma 35mm f/1.4 DG HSM shows itself to be an outstanding lens. At about $899, it represents a terrific value.
But the 35/1.4 doesn't need the price to compete— it can do that based on its performance. Surely this is one of Sigma's very best lenses. Particularly of practical use is its high micro contrast at f/1.4, which makes focusing relatively easy in magnified Live View mode, and also discourages contrast-detect autofocus from making errors. As well as delivering persuasive results wide open.
As I found out today, its lens shade is effective in keeping light rain off the front element even as the body of the lens became covered with water droplets. The build quality seems quite good, but of course only extended use can prove out a design.
I don't yet have a Nikon-mount version, so I cannot yet compare it to Nikon's 35mm f/1.4G, but I plan to do so (and eventually to the two Zeiss 35mm lenses, in Guide to Zeiss).


PITTSBURGH — Rivertowne Brewing, an independent craft brewery located just outside of Pittsburgh in neighboring Murrysville/Export, has announced the release of Source IPA.
Source IPA is a new, year-round core brand for Rivertowne Brewing and will be released in ½ BBLs, 1/6 BBLs and 4/6/12 cans. Additionally, Source IPA will replace Class V IPA in the Dock Party IPA Mix 12 packs. This new offering from Rivertowne Brewing is brewed in the "Brut style," a style that originated in San Francisco, California. Drinkers will find a bone-dry, bubbly IPA coming in at 6.0 percent ABV and 32 IBUs. The additions of Centennial, El Dorado, Ekuanot and Waimea hops present wonderful aromas and a tropical, fruity front-end flavor that gives way to a pleasingly dry, resinous finish.
Jump! IPA – 6.1 percent ABV, 80 IBU – American IPA with flavor complexity ranging from berries, mangos, tropical and stone fruits to grass and resin. In life, there are jumpers and observers. This beer was created for the leapers in life.
Day Float IPA – 5.2 percent ABV, 30 IBU – Hop-forward pale ale with a big tropical bouquet and taste, a pleasing mouthfeel and well-balanced bitter finish that begs you to take another drink. Appealing to a wide variety of drinkers including those who might not normally be fans of IPAs.
Source IPA – 6.0 percent ABV, 32 IBU – Brut-style IPA, a style first brewed in San Francisco, California; this bone-dry, bubbly IPA offers an alternative to the more readily available and sweeter West Coast IPAs and Hazy IPAs. The beer has a pronounced hop aroma and delicate malt flavor but carries the density of water.
Hazy Morning IPA – 6.7 percent ABV, 36 IBU – New England-style IPA with an assertive grapefruit aroma and fresh, green hop flavors that snap your palate to attention and leave you wanting more. This beer is a Citra juice bomb.
Look for Source IPA and the revamped Dock Party IPA Mix 12 packs to begin hitting the streets the week of March 18 across the state of PA.
Rivertowne Brewing is dedicated to producing exceptional, approachable craft beer. Our team of passionate, innovative brewers work tirelessly to create unique recipes with high-quality ingredients and hold each beer to the highest of standards, ensuring the final product in your glass is something you'll enjoy and come back to. Our sustainable packaging allows you to enjoy your favorites at home, the ballpark, or making your way down a peaceful river. At Rivertowne, we emphasize the entire craft beer experience and value the devotion our fans have to our product.


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The Hub invites qualified offerors to submit proposals for the following; Download request for proposal (RFP) and expression of interest (EOI) documents below EOI-008: Expression of Interest (EOI) for Development of Agricultural Policy Position Papers and Case Studies. RFP-NAI-0052: Consultancy services for Strengthening the Coordination of SPS (Sanitary and Phytosanitary) Matters in the East African Community (EAC). RFP-NAI-0053: Consultancy services for Support towards Improved SPS Laboratory Decision Making. RFP-NAI-0054: Consultancy services for Training on Development of National Residue Control Plans. Interested and qualified applicants should submit their applications in PDF (preferred) or other electronic formats on or before Tuesday April 18, 2017 by 11.59pm to tendersTIH@eatradehub.org.
Rwanda Country Representative
The Hub is seeking applications from qualified candidates for the Rwanda Country Representative position. Interested applicants should apply via the link https://daieatradehub.formstack.com/forms/rwanda_country_representative_2017 by March 30, 2017, 11:59 pm East Africa Local time. Only candidates who send their information by the deadline will be eligible. Download full scope of work here.
Partner Opportunity : The Africa Food Prize - Call for Nominations
The Africa Food Prize is the preeminent award recognizing an outstanding individual or institution that is leading the effort to change the reality of farming in Africa-from a struggle to survive to a business that thrives. The US $100,000 prize celebrates Africans who are taking control of Africa's agriculture agenda. It puts a spotlight on bold initiatives and technical innovations that can be replicated across the continent to create a new era of sustainable food security and economic opportunity for all Africans. Nominations for the Africa Food Prize 2017 opened on March 6 2017 and run until June 5 2017. The 2017 winner will be awarded at a high-profile gala dinner in Abidjan, Cote d'Ivoire at the African Green Revolution Forum (AGRF) in September 2017 by Former President of Nigeria, H.E. President Olusegun Obasanjo, and Chair of the Africa Food Prize Committee. To nominate, Click here
Individual Consultants (IC) : Sector Specialists - Kenya National AGOA Strategy and Action Plan Development
The Hub is currently accepting applications from individual consultants for Sector Specialists - Kenya National Africa Growth Opportunity Act (AGOA) Strategy and Action Plan. The Sector Specialists will work with the lead consultant to support the Kenyan Government review its current AGOA export strategy to take advantage of the recent 10 years AGOA extension by the United States of America Government. Interested and qualified applicants should submit their applications to procurementTIH@eatradehub.org by March 17, 2017. Download the scope of work here.
Business Development Associate
The Hub is seeking applications from qualified candidates for the Business Development Associate position. Interested applicants should apply via the link https://daieatradehub.formstack.com/forms/business_development_associate by February 27, 2017, 5.00pm East Africa Local time. Only candidates who send their information by the deadline will be eligible. Download the full scope of work here.
Marketing and Communications Associate
The Hub is seeking applications from qualified candidates for the Marketing and Communications Associate position. Interested applicants should apply via the link https://daieatradehub.formstack.com/forms/marketing_and_communications associate by February 27, 2017, 5.00pm East Africa Local time. Only candidates who send their information by the deadline will be eligible. Download the full scope of work here.
Customs Consultant – Ethiopia Revenue and Customs Authority
The Hub is seeking to recruit a highly qualified Consultant that will serve as an embedded advisor within the Ethiopian Revenue and Customs Authority (ERCA). Interested and qualified applicants should submit their applications in PDF (preferred) or other electronic formats to partnershipfundTIH@eatradehub.org, on or before March 3, 2017, 5:00pm. East Africa local time. Download the Terms of Reference here.
Partner Opportunity:Mettā Launches a Monthly Programme to Catalyse Innovation Across Industry Sectors
Mettā, a global entrepreneurs' club, is launching Nairobi's first Catalyst Programme, a series of industry-specific workshops for startups. Each month, the Mettā Catalyst Programme will bring together industry experts, mentors and corporates to help entrepreneurs running promising early stage companies accelerate growth and take their businesses to the next level. The Catalyst Programme will allow participants to leverage the expertise of industry leaders to build innovative, cost-effective, and sustainable solutions. February's inaugural programme begins with a focus on education and technology, and applications are now open online at www.metta-catalyst.com
Partner Opportunity:Grand Challenges Africa Innovation Grants for African Innovators
The February 17, 2017 deadline for the first call for proposals for the Grand Challenges Africa Innovation Grants is fast approaching. Up to US$100,000 will be given in Innovation Seed Grants for two years to innovators in Africa with any level of experience, working in any discipline in colleges, universities, government laboratories, research institutions, non-governmental and non-profit organisations. Projects which show promising results will be eligible to apply for up to $1 million from AESA or the Bill & Melinda Gates Foundation. The first call for proposals is focused on innovators seeking solutions and strategies: To reduce maternal, neonatal and child deaths in Africa For creative communication approaches to inspire African governments to fund R&D. For more details, visit http://aasciences.ac.ke/aesa/programmes/grand-challenges-africa/innovation-seed-grant-round-1/
Request for Proposals (RFP): Payroll & Employee Benefits Management Services
The Hub is seeking proposals for payroll and employee benefits management services. Interested and qualified applicants should submit their applications in PDF (preferred) or other electronic formats on or before Thursday February 16, 2017 at 11.59 pm East African time to tenderstih@eatradehub.org. Download the full RFP, the Terms & Conditions and the Budget Template. Questions and responses emanating from the RFP can be downloaded here.