Like other top overall draft picks, Auston Matthews came into his rookie season with high expectations from fans and collectors. Although the hype did not quite match that of Connor McDavid, Matthews received a lot of attention and he has not disappointed. Auston Matthews rookie cards have seen tremendous interest and value thanks to his strong play for the Toronto Maple Leafs.
Born and raised in the United States, Auston Matthews has helped re-energize the storied Maple Leafs franchise along with fellow rookie Mitch Marner. Of course, he went through hot and cold stretches, but a strong finish to the season earned him the 2016-17 Calder Memorial Trophy as NHL Rookie of the Year.
Shop for Auston Matthews rookie cards on eBay.
As is typically the case for first-year players, Auston Matthews rookie cards started off slowly with redemptions to begin the collecting season. However, the options picked up as new rookie cards featuring Matthews continued to roll out.
The list below documents all the Auston Matthew rookie cards from 2016-17 hockey releases, including his key base, autographs, relics and other inserts.
Both of the Auston Matthews rookie autographs in 2016-17 Fleer Showcase are short prints. The main signed version is limited to 99 while the majority of the Hot Prospects set checks in at 499 copies. In addition, the autographed patch card flips to a horizontal layout and drops the print run to just 35 copies. Collectors can also find several 90s-themed inserts for Matthews in greater supply.
Although he missed out on the first run of OPC, 2016-17 O-Pee-Chee Platinum puts Matthews on chromium stock. The Marquee Rookies subset is the place for budget collectors to look and the many parallels greatly increase the rarity and variety. Matthews is also found in the on-card Rookie Auto insert as part of Group A, which has overall odds of 1:501 packs. These also bring with them lots of colorful parallels.
One of his more plentiful options at 999 copies, the Matthews rookie in 2016-17 SP Authentic still offers an on-card signature, making it more available than his other signed RC cards. There is also a limited Black Future Watch Autograph with gold ink. Both signed versions originally came as redemptions. In addition, Matthews is in the Authentic Moments subset with base and autograph versions celebrating his NHL debut.
The rarest of the bunch, 2016-17 SP Game Used has Authentic Rookies for the top players that are numbered to their jersey number. For Matthews, that means only 34 copies. While this makes it nearly impossible for the average collector to obtain, parallels are more plentiful. There are also jersey parallels, numbered to 399, as well as very rare autograph and autograph patch versions.
One of the more distinct Auston Matthews rookie cards, the Shadow Box Rookies subset in 2016-17 SPx is numbered to 249, but it adds relic and autograph relic editions. Collectors have also shown considerable interest in the Rookies and Extreme Black Holo Shield Autographs for Matthews.
Available in several forms across the primary set, 2016-17 Ultimate gives collectors a base Auston Matthews rookie card in the Ultimate Introductions Rookies subset as part of Level 4, which has overall group odds of 1:12 boxes. He also has a signed Ultimate Rookies cards with an on-card autograph, and one with an autograph patch.
The flagship rookie set from UD, the Young Guns line typically offers the most popular cards each year and that is also the case for Matthews in 2016-17 Upper Deck Series 1. Despite the simple nature of the card, values are strong. Plus, rare parallels like the acetate Clear Cut, as well as Exclusives (#/100) and High Gloss (#/10), push prices much higher.
Matthews also has a dual checklist card with teammate William Nylander in the base set (#250), along with a very limited NHL Draft short print card that is shown below.
Although his primary Young Guns cards arrived in Series 1, 2016-17 Upper Deck Series 2 is the place to find the Auston Matthews UD Canvas YG card.
In addition, despite missing out on the main OPC set, his base O-Pee-Chee rookie is still an option thanks to an update in Upper Deck Series 2. He has both the standard Marquee Rookies subset and the Retro variation.
One of the earliest '16-17 cards that can be tied to Matthews, most collectors suspected these 2016-17 Artifacts redemptions would yield Auston Matthews rookie cards despite not naming him on the card. Upper Deck later confirmed both for the Maple Leafs' young stud. The base rookie is on the left while card #I comes as various relics and autograph editions.
Because of several delays, 2016-17 UD Black is the final Auston Matthews rookie card issued for the season instead of The Cup. The set includes the main Matthews option in the Lustrous Rookies subset. Hard-signed, Matthews is a short print with just 99 copies. He is also in many of the autographed inserts.
Taking the name quite seriously, 2016-17 UD Black Diamond includes actual diamonds in the primary rookie set. The Diamond Relic Rookies also come in single, double and triple form, with Matthews as the sole quad diamond rookie.
Also worth noting is the Rookie Gems insert for Matthews that is a bit more affordable and plentiful at 399 base copies.
2016-17 Black Diamond provided some of the earliest Auston Matthews autographs, as well. While the premium set offers several different insert choices, all are still limited. This includes the signed Rookie Booklet Relics card below. He also has notable autographs in Signature Rookie Materials and Silver on Black Signatures (redemption).
Part of the high-end brand without a true home of its own, 2016-17 Exquisite Collection is actually found exclusively in other products. Collectors' first shot at Auston Matthews' Exquisite cards came in 2016-17 Black Diamond. In addition to his Rookie Draft Day and several different rookie relics, he also has a low-numbered Rookies card that is limited to his jersey number (#/34).
Round two of Exquisite Collection arrived in 2016-17 UD Ice. With it came a pair of Auston Matthews Exquisite autographs, including a 2009-10 tribute numbered to just 25 copies. Lastly, there was 2016-17 The Cup, featuring the RAP (#/34), and Endorsements auto relic (#/50).
As NHL collectors know, UD ICE means acetate, and for Auston Matthews, the end result is extreme rarity. Included in Level 1 of the 2016-17 Upper Deck Ice Premieres subset, Matthews only has 99 cards and prices are steep. He also has a signed version numbered to 25.
Another early redemption option, Auston Matthews is included in 2016-17 Upper Deck MVP with a 2016 NHL #1 Draft Pick card that comes in base and autograph editions. In addition, he is part of the Atlantic Division Rookie redemption set. Collectors can find exclusive physical completion award cards, shown below on the right, through ePack for those that make the digital set.
Issued in a distributor-exclusive promo set, Matthews has a base rookie and a blue uniform image variation in 2016-17 UD Overtime Hockey. Both came in Wave 3 packs.
Solicited as a Canada-only release at Walmart, collectors across both Canada and the United States have found the retail offering. 2016-17 Upper Deck Parkhurst is a low-end set, but the deep base checklist includes an Auston Matthews rookie card. This is not to be confused with the blaster-exclusive Parkhurst Rookies Preview insert from '16-17 UD Series 1, shown on the right, that has a similar design.
The acetate Rookie Auto Patch in 2016-17 UD Premier has everything an Auston Matthews' collector is looking for in a rookie card. Limited to 199 copies, the moderate jersey swatch is centered between an image of Matthews and an on-card signature.
With just 99 copies, 2016-17 Upper Deck The Cup is the Auston Matthews rookie card to own if your budget allows it. The ultra-premium brand has no match among NHL cards. Matthews also has several other impressive autographs in the product, including the 2005-06 Tribute autograph patch shown below. In addition, there are several Exquisite Collection inserts.
Becoming a frenzied annual tradition, 2016-17 UD Tim Horton's brought collectors one of the earliest shots at Matthews, albeit at a staggering 1:18,000 packs. The redemptions are now live and yielding impressive sales.
Thrice as nice, 2016-17 UD Trilogy has tiered rookie cards with three main Rookie Premieres options for Auston Matthews. Among these are the Level 1 base cards, Level 2 Uncommon Autographs, and Level 3 Rare Autographs. Unsigned relic cards drop at each level and a triple signature card in Level 3 pairs Matthews with teammates Mitch Marner and William Nylander.
No, your eyes do not deceive you. That floating head might not seem all that impressive but it belongs to Auston Matthews. Found in the 2016 UD World Cup of Hockey promo set, this is actually the first live, licensed, and pack-pulled card for Matthews.
Part of a late-season release, Upper Deck wasted no time getting Auston Matthews redemptions into the hobby even though the subject was not confirmed until later. 2015-16 UD Portfolio features multiple base and autographed versions for Matthews, who is redemption #1.
2016-17 Ultimate Collection Achievements Auston Matthews VIP Rookie!
i am curious which is the rookie card for Auston MAthews? there are so many on the market hard to understand which is the real one.
Great cards and can't wait for the recent ones to appear!
Will there be a complete Auston Matthews rookie card gallery and checklist?
I'm pretty sure everything is here. What other sets are missing?
His true rookie card and variation from 2016/17 Upper Deck Overtime is not there.
16 17 Upperdeck Black Auston Matthews Obsidian Sig. RC Auto! BGS 9! Mint! POP!


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Pfizer COVID vaccine for kids under 5 could be ready next month
An emergency use authorization request is expected to be made to the US Food and Drug Administration (FDA) as early as February 1, 2022.
The Pfizer COVID-19 vaccine could be available for children under 5 as soon as the end of next month, according to reports.
An emergency use authorization request is expected to be made to the US Food and Drug Administration (FDA) as early as Tuesday, a person familiar with the matter confirmed to The Associated Press.
If successful, it would clear the way for a two-dose regimen to be available for children 6 months to 5 years old as soon as late February, the source said.
# Pfizer# COVID# vaccine# for# kids# under# 5# could# be# ready# next# month
ABD Ankara Büyükelçisi, İmamoğlu'nu Ziyaret Etti

redpajama_set_name: RedPajamaCommonCrawl


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While I'm deeply involved in entrepreneurship, breathing it day in and day out, and actively follow many discussions around it, I tend to shy away from writing about it most of the time. Why? Because I'm generally too busy doing the entrepreneurship to talk about it. In the end, it's the facts of our accomplishments that will speak far louder than some hollow words.
Building a sustainable business is the only thing that matters. Entrepreneurs get caught up worrying about all kinds of shiny objects: tech trends, investors, hot markets, compensation schemes, founder personalities, community — you name it. Those things are interesting, but there's only one thing that matters: building a sustainable business. That means recurring revenue and controllable costs. Watch those two items and then maybe you'll have something to talk about.
Know your CAC/CPA and LTV. If you're building a recurring revenue business, you need to know your customer acquisition cost and lifetime value of the customer. You need to understand this really, really well. To understand customer acquisition cost, you need to know all of the costs that go into acquiring a new, paying customer. To understand lifetime value, you need to understand your customer retention rates really well. If this makes your eyes glaze over, you're not an entrepreneur.
The hard part comes after the funding. It may seem like securing funding is a great milestone, and you'll be tempted to pat yourself on the back. Do that for a minute, but get the hell back to work. You have real work to do now. If you don't understand how to deploy that funding, and more importantly have a plan for what happens when (not if ) you run out, you'll be out of options. Be humble. This stuff is hard.
The Series A crunch is real. The funding environment today is quite brutal and you can expect to spend several months of your time working just on securing a "Series A" size funding round (for the sake of simplicity let's define that as a post-seed round of $1M or more). Investors are looking for not only traction, but real revenues, social proof, and growth. They want to know why you are the entrepreneurial team that's going to survive and thrive. There are thousands of other teams out there who won't, so the odds are against you.
My dog can raise a seed round in this climate. With the myriad startup funds, accelerators, and crowdfunding available today, it's easier than ever to raise a seed round. While raising a seed or small angel round is definitely a validation that you may not be insane, it's no validation that you're sane either. Startups are hot and these days, everyone's an "angel investor" (even me.) But just because you raise that seed round doesn't mean you will have a clear path forward.
You are responsible for your success — not your investors or advisors. It's tempting to think that having a rockstar list of investors and advisors is going to catapult you to success. In fact, that's just not the case. While having "name brand" people on your team can accelerate the growth and create additional options for your successful business, the onus is on you to deliver that successful business. They are not going to make it happen for you. It's ALL on you.
Building products is hard and requires tireless analysis and iteration. Building products is ridiculously hard work. Every day you need to devise new experiments and analyze the results. You need to continuously iterate and improve every aspect of your product. You have to make clear headed choices about what is important and what's not, frequently leaving even good ideas unfinished. In short, if you're not comfortable with scientific method, numeric and statistical analysis, and ambiguity (yes, ambiguity ALL THE TIME) then you have no business being a founder.
I hear new entrepreneurs talk all the time about how everything is going so great — they had a great pitch meeting or secured a funding commitment, just hired a new person, or setup some shiny new piece of technology. And those things are all great. But remember, until you have a product that is generating real recurring revenue and you fully understand the dynamics, you don't have a business, you have a conjecture.
And don't get me wrong, as a fellow entrepreneur, I love a good conjecture. But what is really impressive is when you can start to make make it sing and scale. That requires tons of hard work — hard work that's not flashy, doesn't let you write upbeat self-congratulatory status updates, or put out self-serving press releases.
All that matters is your customers, the value you're creating for them, and the dollars and goodwill that value generates. Let's talk about that, because the rest is noise.


Endless protected miles of the Atlantic Ocean are host to stunning coral reefs and enchanting mangrove swamps at John Pennekamp. The first undersea state park in the U.S., the park offers a variety of guided diving options, including diving certification courses and clinics for underwater photography and fish identification. If you're diving, do NOT miss the SS Benwood, a World War II shipwreck that sits at a depth of 50 feet, and the Christ of the Abyss statue, located almost 25 feet of water near the Dry Rocks reef.
Anchor down onto Florida's Anna Maria Island, and you may never book a return trip home. From hidden, white-sand beaches with crystal-blue water to Instagram-worthy sunsets and delicious seafood at waterfront restaurants, you can experience all the trappings of an exotic, tropical vacation without even having to leave the United States.
Neighbored by the Gulf of Mexico and Tampa Bay, this seven-mile-long island invites travelers to soak up the vibes of its three cozy towns: Anna Maria in the north, Bradenton Beach in the south, and Holmes Beach in between.
Tampa Bay, the largest estuary in Florida, is up and coming as one of the best places to live, and to visit. In the bay area you will the city of St. Petersburg; known for its water-front focused community. But venture a few miles south and you'll discover Egmont Key, which is only accessible by boat.
Designated a National Wildlife Refuge in 1974, Egmont Key extends the allure of history and nature via a pristine, undeveloped landscape and relics of a former military installation. Today, this 440-acre island is still preserved as a remote island with an abundance of wildlife, and will make you not want to leave this secret sanctuary.
Looking for a different scene other than coastal waters? Then Silver Glen Springs is for you - a hidden inland in the Ocala national Forest, about 40 miles from Ocala. This natural swimming pool offers clear and shallow water perfect for swimming and snorkeling. While boats are not allowed in the spring pool, the spring run is open for recreational boating and leads into the St. Johns River and Lake George.
Few destinations that offer such a wealth of sites and activities as this jewel. Boasting the #1 beach in America (Siesta Key), the area is replete with resorts, marinas, theaters, world-class dining, and fun activities.
Venture to Siesta Key on a Sunday night and enjoy the rhythmical sounds of the "Drum Circle" (you can even join in on the fun!) Don't forget to take a look around Siesta Key Village and explore the many shops and exquisite dining locations for a day that you won't soon forget.
Whatever your idea of a vacation is, you can count on Siesta Beach to provide entertainment and fun for the whole family. Here's to a relaxing weekend and as always, we'll see you on the water!
New Smyrna is one of the best surf towns with a historic feel of thriving arts community loaded with cafes and eclectic shops you can't miss to explore. For boaters, the coastline offers extensive 13 miles of clean beaches with secluded estuaries. We suggest you visit Disappearing Island, a local favorite for fishing, birding, and get up close with dolphins and manatees. If you don't own a boat, watercraft rentals are available from the local marinas.
If you're picky about your beaches, Caladesi Island in Clearwater, FL gives you the kind of natural, secluded escape you're looking for. In fact, this small island feels more like the Caribbean than Florida! Caladesi Island sits just west of Dunedin, Florida on the gulf coast, and is easily accessible by boat. You can drop your anchor virtually anywhere and bring your beach chairs to shore to enjoy a calm sea breeze.
Go Out and Have Some On-The-Water Fun!
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Jul 12, 1999 in "IllumiNations: Reflections of Earth"
Earth Globe is the world's first spherical video display system, wrapped in 15,000 LEDs (Light-Emitting Diodes.
The grand finale to every evening during the 15-month-long celebration at Epcot is IllumiNations 2000: Reflections of Earth, the most thrilling and technically complex production ever created for the most popular nighttime spectacle in Walt Disney World history. The all-new nighttime extravaganza features fireworks, full-color lasers, lights, water fountains, fire and music.
Leading the creative team are director Don Dorsey, creator of the original Main Street Electrical Parade, and fireworks designer Eric Tucker, the top medal winner for the past three years in the International Fireworks Exposition.
IllumiNations 2000: Reflections of Earth tells the story of the dawn of the third millennium, a symbolic time of rebirth, a global turning point for the human race," says Dorsey. "We're presenting the entire history of our planet, from the beginning of time to the present, and looking into the future."
As Tapestry of Nations goes dark, shooting stars streak across the skies above World Showcase Lagoon, colliding into a ball of fire. Plumes of fire light the sky in an explosion of sound and light. Steam and smoke rise, creating a sense of chaos, a sense of the dawning of time.
A single voice becomes a chorus as the show focuses on a giant spinning globe in the middle of World Showcase Lagoon – a spherical video screen nearly three stories high projecting vivid images that celebrate human diversity and the unified spirit of mankind. The high-tech sphere "blossoms" to release a brilliant flaming gas torch which lifts 38 feet into the air in the show's emotional closing, an artistic expression of mankind's brilliant future as the music soars, lasers shoot skyward, fireworks illuminate the skies and flames leap across the surface of the lagoon.
As the final chord fades, a massive explosion of sound and colors is united, a symbol of oneness in today's world as we move forward into a new millennium.


Statistics applied to: analysing iron levels in New Zealand infants; modelling the profiles of New Zealand women who would consume alcohol when pregnant; analysing trace element data in relation to food authentication with particular application to oysters, ginseng and honey using multivariate techniques; modelling changing attitudes to sustainability of students while at university using confirmatory factor analysis and linear mixed models to investigate a large cohort of students over four years; modelling dolphin - human tourist interactions in the Red Sea off the coast of Egypt.
Waid, J.S., Harraway, J.A., Hodgkinson, I.J. and Swedlund, B.E. Report of visit of Colombo Plan survey team to Khon Kaen University in Thailand, January - March 1974. Report submitted to New Zealand Ministry of Foreign Affairs.(1974) 206pp.
Parackal, S.M., Parackal, M.K. and Harraway, J.A. Prevalence and correlates of drinking in early pregnancy among women who stopped drinking on pregnancy recognition. Maternal and Child Health Journal, 17(3), 520-529, 2013.
Shephard, K., Harraway, J., Lovelock, B., Skeaff, S., Strack. M. & Jowett, T. Exploring the impact of higher education experiences on the sustainability attributes of students. New Zealand Association for Environmental Education 6th Biennial Conference. Hamilton, New Zealand. (January 2012).
Shephard K, Harraway J, Lovelock B, Slooten E, Skeaff S, Strack M and Jowett T 2011 Monitoring changes in the environmental attitudes of higher education students, in K Shephard, T Harland, A Cohen (eds) Proceedings of Spotlight on Technology and Learning Colloquium 2011 Dunedin Higher Education Development Centre, University of Otago. ISBN 978-0-473-19469-7.
Shephard K, Mann S, Smith N, Harraway J, Deaker L and Broughton-Ansin F (2010) Exploring the roles of national parks and natural areas in raising society's green credentials. Extended abstract published in the Proceedings of the Centre for Recreation Research Symposium 2010, Recreation Values and Natural Areas, 18 – 19th March 2010, University of Otago.
Forbes, S., Harraway, J. and Hohmann-Marriott, B.. Using Web Apps in the Classroom Style. In M. A. Sorto, A. White, and L. Guyot (Eds.), Looking back, looking forward. Proceedings of the Tenth International Conference on Teaching Statistics, (ICOTS10, July, 2018), Kyoto, Japan. Voorburg, The Netherlands: International Statistical Institute.


The Multisport enables athletes to play many different sports without compromising on quality or performance.
Motivation's Multisport is flexible and adjustable; it can meet the needs of multiple athletes and can be used for multiple sports. This makes it perfect for use in schools, clubs and community sports projects.
This chair is also used in competitive environments. It is currently being used by Afghanistan's national wheelchair basketball team.
To use the Multisport for basketball or rugby, leave the toe-guard in place. To enjoy tennis, badminton or other court-based activities, simply remove it!
The Multisport is easy to assemble, and is available in a junior model and four adult seat widths. Each size is colour-coded so it's easy for participants to pick the right chair at the start of a session.
Discounts are available for orders of 10 units or more. We also offer partnership subsidised rates for Paralympic Committees, national basketball and tennis federations and partnering NGOs.


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Journal of Neuromuscular Diseases - Volume 8, issue 2
The Journal of Neuromuscular Diseases aims to facilitate progress in understanding the molecular genetics/correlates, pathogenesis, pharmacology, diagnosis and treatment of acquired and genetic neuromuscular diseases (including muscular dystrophy, myasthenia gravis, spinal muscular atrophy, neuropathies, myopathies, myotonias and myositis).
The journal publishes research reports, reviews, short communications, and letters-to-the-editor and will consider research that has negative findings. The journal is dedicated to providing an open forum for original research in basic science, translational and clinical research that will improve our fundamental understanding and lead to effective treatments of neuromuscular diseases.
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Molecular Mechanisms of Skeletal Muscle Hypertrophy
Authors: Schiaffino, Stefano | Reggiani, Carlo | Akimoto, Takayuki | Blaauw, Bert
Abstract: Skeletal muscle hypertrophy can be induced by hormones and growth factors acting directly as positive regulators of muscle growth or indirectly by neutralizing negative regulators, and by mechanical signals mediating the effect of resistance exercise. Muscle growth during hypertrophy is controlled at the translational level, through the stimulation of protein synthesis, and at the transcriptional level, through the activation of ribosomal RNAs and muscle-specific genes. mTORC1 has a central role in the regulation of both protein synthesis and ribosomal biogenesis. Several transcription factors and co-activators, including MEF2, SRF, PGC-1α 4, and YAP promote the growth of the myofibers. Satellite cell …proliferation and fusion is involved in some but not all muscle hypertrophy models. Show more
Keywords: Skeletal muscle, muscle hypertrophy, translational control, transcriptional control, ribosomal biogenesis, mTOR, MEF2, SRF
DOI: 10.3233/JND-200568
Citation: Journal of Neuromuscular Diseases, vol. 8, no. 2, pp. 169-183, 2021
Current View of Diagnosing Small Fiber Neuropathy
Authors: Raasing, Lisette R.M. | Vogels, Oscar J.M. | Veltkamp, Marcel | van Swol, Christiaan F.P. | Grutters, Jan C.
Abstract: Small fiber neuropathy (SFN) is a disorder of the small myelinated Aδ -fibers and unmyelinated C-fibers [5, 6 ]. SFN might affect small sensory fibers, autonomic fibers or both, resulting in sensory changes, autonomic dysfunction or combined symptoms [7 ]. As a consequence, the symptoms are potentially numerous and have a large impact on quality of life [8 ]. Since diagnostic methods for SFN are numerous and its pathophysiology complex, this extensive review focusses on categorizing all aspects of SFN as disease and its diagnosis. In this review, sensitivity in combination with specificity of different diagnostic methods are described using …the areas under the curve. In the end, a diagnostic work-flow is suggested based on different phenotypes of SFN. Show more
Keywords: Autonomic dysfunction, nerve fiber density, small fiber neuropathy, diagnostic accuracy
Safety Monitoring of Gene Therapy for Spinal Muscular Atrophy with Onasemnogene Abeparvovec –A Single Centre Experience
Authors: Friese, Johannes | Geitmann, Stephanie | Holzwarth, Dorothea | Müller, Nicole | Sassen, Robert | Baur, Ute | Adler, Kristin | Kirschner, Janbernd
Abstract: Background: Recently gene therapy with onasemnogene abeparvovec has been approved for the treatment of spinal muscular atrophy (SMA). As the experience from clinical trials is limited, there are still uncertainties for which patient population the treatment can be considered safe and effective. Methods: We report our experience with eight consecutive patients with SMA who were treated with the standard dose of onasemnogene abeparvovec (1.1×1014 vg/kg) at the University Hospital Bonn, Germany. All patients received prophylactic immunosuppression with 1 mg/kg/d prednisolone for four weeks starting on the day before gene therapy. Results: We treated eight patients …(4 male, 4 female, age range 10–37 months) with a body weight between 7.1 and 11.9 kg. All patients had 2 or 3 copies of the SMN2 -gene and were previously treated with nusinersen. Following treatment with onasemnogene abeparvovec all patients showed a temporary increase of the body temperature and an increase of transaminase levels. In all but one patient it was necessary to increase or prolong the standard steroid dose to control the immune response. In one severe case, liver damage was associated with impaired liver function. This patient received a steroid pulse therapy for five days. Blood counts revealed asymptomatic thrombocytopenia (<150×109 /L) in 6/8 patients and a significant increase of monocytes following gene therapy. Liver values and blood counts returned to almost normal levels during the post-treatment observation period. Troponin I increased above normal limit in 4/8 patients but was not associated with any abnormalities on cardiac evaluation. Conclusions: In a broader spectrum of patients, treatment with onasemnogene abeparvovec was associated with a higher rate of adverse events. In our cases it was possible to control the immune response by close monitoring and adaptation of the immunosuppressive regimen. Further research is needed to better understand the immune response following gene therapy and ideally to identify patients at risk for a more severe reaction. Show more
Keywords: Spinal muscular atrophy, gene therapy, onasemnogene abeparvovec, adeno-associated viral vector, safety, AAV9
Clinical Outcomes in Patients with Spinal Muscular Atrophy Type 1 Treated with Nusinersen
Authors: de Holanda Mendonça, Rodrigo | Jorge Polido, Graziela | Ciro Jr, Matsui | Jorge Fontoura Solla, Davi | Conti Reed, Umbertina | Zanoteli, Edmar
Abstract: Background Spinal muscular atrophy type 1 (SMA1) is a motor neuron disease associated with progressive muscle weakness, ventilatory failure, and reduced survival. Objective: To report the evaluation of the nusinersen, an antisense oligonucleotide, on the motor function of SMA1. Methods This was a longitudinal and observational study to assess the outcomes of nusinersen therapy in SMA1 patients using the HINE-2 and CHOP-INTEND scales. Results Twenty-one SMA1 patients (52.4% males) were included; the mean age at first symptoms was 2.7 months (SD =±1.5), and the mean disease duration at first dose was 34.1 (SD =±36.0) months. During …posttreatment, the mean gain on the CHOP-INTEND was 4.9, 5.9, 6.6, and 14 points after 6, 12, 18, and 24 months, respectively. Starting medication with a disease duration of less than 12 months and/or without invasive ventilation were predictors of response on CHOP-INTEND. Of the patients, 28.6% acquired a motor milestone or gained at least three points on the HINE-2. The daily time for ventilatory support was reduced after treatment in most of the patients with noninvasive ventilation at baseline. No change in the daytime use of ventilation was observed in most of the patients using invasive ventilation at baseline. Conclusions Nusinersen produces improvements in motor and respiratory functions, even in long-term SMA1 patients. However, patients under invasive ventilation at the beginning of the treatment experience little benefit. Show more
Keywords: Spinal muscular atrophy, SMN1, nusinersen, antisense oligonucleotide, motor neuron disease
Results from a 3-year Non-interventional, Observational Disease Monitoring Program in Adults with GNE Myopathy
Authors: Lochmüller, Hanns | Behin, Anthony | Tournev, Ivailo | Tarnopolsky, Mark | Horváth, Rita | Pogoryelova, Oksana | Shah, Jinay | Koutsoukos, Tony | Skrinar, Alison | Kakkis, Emil | Bedrosian, Camille L. | Mozaffar, Tahseen
Abstract: BACKGROUND: GNE myopathy is a rare, autosomal recessive, muscle disease caused by mutations in GNE and is characterized by rimmed vacuoles on muscle biopsy and progressive distal to proximal muscle weakness. OBJECTIVE: Investigate the clinical presentation and progression of GNE myopathy. METHODS: The GNE Myopathy Disease Monitoring Program was an international, prospective, observational study in subjects with GNE myopathy. Muscle strength was assessed with hand-held dynamometry (HHD), with upper extremity (UE) and lower extremity (LE) composite scores reflecting upper and lower extremity muscle groups, respectively. The GNE myopathy–Functional Activity Scale (GNEM-FAS) was used to further …assess impairment in mobility, upper extremity function, and self-care. RESULTS: Eighty-seven of 101 enrolled subjects completed the trial until study closure by the sponsor; 60 completed 36 months. Mean (SD) HHD UE composite score decreased from 34.3 kg (32.0) at baseline to 29.4 kg (32.6) kg at month 36 (LS mean change [95%CI]: –3.8 kg [–5.9, –1.7]; P = 0.0005). Mean (SD) HHD LE composite score decreased from 32.0 kg (34.1) at baseline to 25.5 kg (31.2) at month 36 (LS mean change [95%CI]: –4.9 [–7.7, –2.2]; P = 0.0005). GNEM-FAS scores were more severe at baseline in subjects who walked <200 meters versus ≥200 meters in 6 minutes; in both groups, GNEM-FAS total, mobility, UE, and self-care scores decreased from baseline through month 36. CONCLUSIONS: These findings demonstrate progressive decline in muscle strength in GNE myopathy and provide insight into the appropriate tools to detect clinically meaningful changes in future GNE myopathy interventional trials. Show more
Keywords: Myopathies, muscular diseases, muscle weakness, N-acetylneuraminic acid
A Multidisciplinary Evaluation of Patients with DMD in An Italian Tertiary Care Center
Authors: LoMauro, A. | Gandossini, S. | Russo, A. | Velardo, D. | Comi, G.P. | Turconi, A.C. | Bresolin, N. | Aliverti, A. | D'Angelo, M.G.
Abstract: With more widespread prolonged survival, Duchenne muscular dystrophy patients progressively experience multisystem complications. We retrospectively reviewed the charts of 132 Duchenne patients (112 alive/20 dead, age 3.5÷32.3 years) with the aims: 1) to provide a comprehensive description of the clinical status considering different aspects of the disease; 2) to propose a new scoring tool able to consider and pool together heterogeneous different functional. Five functions were analyzed: cardiac, respiratory, nutritional, ambulation and scoliosis. For each function, different items were considered and classified according to clinical severity (as indicated by international guidelines) and an incremental scoring was assigned. In addition, a …global score incorporating all functions was defined. The scoring system confirmed that despite the significant protective role of steroids, all functions deteriorated with age. The severity of the global score became significantly higher since the age of 13 years. The severity of cardiac, respiratory and nutritional dysfunction was higher since 18 years. Deceased patients were characterized by significantly worse cardiac function, absence of steroid therapy and later use of respiratory assistive devices. The index proposed in this pilot study is a promising tool able to aggregate and correlate heterogeneous functions. It could become either an individual prognostic indicator of decline or a global score to evaluate changes in clinical trials therefore allowing multicenter studies, optimizing the management of both the primary and the secondary complications of the disease and understanding their relative impact. Show more
Keywords: Duchenne muscular dystrophy, natural history, respiratory function, cardiac function, nutrition, indexes
Iranian Registry of Duchenne and Becker Muscular Dystrophies: Characterization and Preliminary Data
Authors: Bayat, Farhad | Sarmiento, Isis G. | Ahmadian, Negar | Dehghani, Zahra
Abstract: Duchenne (DMD) and Becker muscular dystrophies (BMD) are rare neuromuscular disorders caused by mutations in the dystrophin gene and failure in its protein production. The absence or the reduced expression of dystrophin render muscles prone to damage, including the cardiac and respiratory muscles with reduced life expectancy. Careful planning for clinical trials will require a sufficient number of confirmed cases to meet the inclusion criteria. National registries for rare disorders serve as an essential tool for personalized medicines or mutation-specific trials to facilitate patient recruitment. The Iranian Registry of DMD and BMD (IRDAB) collects detailed molecular data of Iranian DMD/BMD …patients and carriers according to the TREAT-NMD Global Neuromuscular Network guidelines. As of March 2020, five hundred and twenty-two cases are registered. The registry incorporates multi-level web and database technologies, where registrants can access their data and compare it to the cumulative data. The registry's objectives are to recruit eligible patients for clinical trials and provide sufficient data for the national program of disease surveillance and social planning. Furthermore, the registry provides accurate epidemiological data, phenotype/genotype correlation, and evaluate the standards of care in Iran. Show more
Keywords: Iran, IRDAB, DMD BMD, duchenne becker muscular dystrophy, registry, TREAT-NMD
Elucidation of the Genetic Cause in Dutch Limb Girdle Muscular Dystrophy Families: A 27-Year's Journey
Authors: ten Dam, L. | de Visser, M. | Ginjaar, Ieke B. | van Duyvenvoorde, Hermine A. | van Koningsbruggen, Silvana | van der Kooi, Anneke J.
Abstract: Background: A Dutch cohort of 105 carefully selected limb girdle muscular dystrophy (LGMD) patients from 68 families has been subject to genetic testing over the last 20 years. After subsequent targeted gene analysis around two thirds (45/68) of the families had received a genetic diagnosis in 2013. Objective: To describe the results of further genetic testing in the remaining undiagnosed limb girdle muscular dystrophy families in this cohort. Methods: In the families of the cohort for whom no genetic diagnosis was established (n = 23) further testing using Sanger sequencing, next generation sequencing with gene panel analysis …or whole-exome sequencing was performed. In one case DNA analysis for facioscapulohumeral dystrophy type 1 was carried out. Results: In eight families no additional genetic tests could be performed. In 12 of the remaining 15 families in which additional testing could be performed a genetic diagnosis was established: two LGMDR1 calpain3-related families with CAPN3 mutations, one LGMDR2 dysferlin-related family with DYSF mutations, three sarcoglycanopathy families (LGMDR3-5 α -, β - and γ -sarcoglycan-related) with SGCA/SGCB/SGCG mutations, one LGMDR8 TRIM 32-related family with TRIM32 mutations, two LGMDR19 GMPPB-related families with GMPPB mutations, one family with MICU1- related myopathy, one family with FLNC -related myopathy and one family with facioscapulohumeral dystrophy type 1. At this moment a genetic diagnosis has been made in 57 of the 60 families of which DNA was available (95%). Conclusion: A genetic diagnosis is obtained in 95% of the families of the original Dutch LGMD cohort of which DNA was available. Show more
Keywords: Limb girdle muscular dystrophy, sanger sequencing, gene panel, whole exome sequencing
Intrafamilial Phenotypic Variability of Collagen VI-Related Myopathy Due to a New Mutation in the COL6A1 Gene
Authors: Bardakov, Sergey N. | Deev, Roman V. | Magomedova, Raisat M. | Umakhanova, Zoya R. | Allamand, Valérie | Gartioux, Corine | Zulfugarov, Kamil Z. | Akhmedova, Patimat G. | Tsargush, Vadim A. | Titova, Angelina A. | Mavlikeev, Mikhail O. | Zorin, Vadim L. | Chernets, Ekaterina N. | Dalgatov, Gimat D. | Konovalov, Fedor A. | Isaev, Artur A.
Abstract: A family of five male siblings (three survivors at 48, 53 and 58 years old; two deceased at 8 months old and 2.5 years old) demonstrating significant phenotypic variability ranging from intermediate to the myosclerotic like Bethlem myopathy is presented. Whole-exome sequencing (WES) identified a new homozygous missense mutation chr21:47402679 T > C in the canonical splice donor site of the second intron (c.227 + 2T>C) in the COL6A1 gene. mRNA analysis confirmed skipping of exon 2 encoding 925 amino-acids in 94–95% of resulting transcripts. Three sibs presented with intermediate phenotype of collagen VI-related dystrophies (48, 53 and 2.5 years old) while …the fourth sibling (58 years old) was classified as Bethlem myopathy with spine rigidity. The two older siblings with the moderate progressive phenotype (48 and 53 years old) lost their ability to maintain a vertical posture caused by pronounced contractures of large joints, but continued to ambulate throughout life on fully bent legs without auxiliary means of support. Immunofluorescence analysis of dermal fibroblasts demonstrated that no type VI collagen was secreted in any of the siblings' cells, regardless of clinical manifestations severity while fibroblast proliferation and colony formation ability was decreased. The detailed genetic and long term clinical data contribute to broadening the genotypic and phenotypic spectrum of COL6A1 related disease. Show more
Keywords: Ullrich congenital muscular dystrophy, fibroblasts, contractures, myosclerotic phenotype of Bethlem myopathy, collagenopathy, type VI collagen, leaky splicing, COL6A1
Clinical Experience with Eculizumab in Treatment-Refractory Acetylcholine Receptor Antibody-Positive Generalized Myasthenia Gravis
Authors: Katyal, Nakul | Narula, Naureen | Govindarajan, Raghav
Abstract: Background: Although established therapies are effective in most patients with generalized myasthenia gravis (gMG), some patients do not respond or they experience intolerable adverse events, highlighting the need for better tolerated, targeted therapies for treatment-refractory gMG. Objective: To describe real-world experience with eculizumab in patients with treatment-refractory acetylcholine receptor antibody-positive (AChR+) gMG. Methods: Retrospective chart review of 15 patients with treatment-refractory AChR+ gMG treated for 12 months with eculizumab (900 mg/week for 4 weeks then 1200 mg every 2 weeks). Outcome measures were Myasthenia Gravis–Activities of Daily Living (MG-ADL) scores, number of exacerbations, single-breath count test (SBCT) score, …medication changes, selected Quantitative Myasthenia Gravis (QMG) evaluations, and adverse events. Data collected at 3-monthly intervals for 12 months before and after eculizumab initiation were analyzed. Results: Clinically meaningful reductions in total MG-ADL scores were observed at 3 months following eculizumab initiation and maintained up to 12 months in all patients. After 12 months' eculizumab treatment, there was a significant reduction in the number of acute exacerbations; mean (SD) SBCT score improved from 28.13 (0.33) to 50.26 (2.86); all patients achieved a 'none' or 'mild' rating for QMG evaluations; all patients reduced their daily prednisone dose; and nine patients had discontinued pyridostigmine. At the end of treatment, intravenous immunoglobulin was discontinued in all six patients receiving this therapy at eculizumab initiation. Eculizumab was well tolerated. Conclusions: This real-world study demonstrated improvement in outcome measures and decreased concomitant drug requirement within 12 months of eculizumab initiation in patients with treatment-refractory AChR+ gMG. Show more
Keywords: Myasthenia gravis, ACh receptors, neuromuscular junction, complement inactivating agents, activities of daily living, corticosteroids, exacerbations, diplopia, prednisone, immunoglobulin G


text:
<!DOCTYPE html>

		<title>Documentation of {{className}}</title>
		<link rel="stylesheet" href="../../../../../../styles/dbm/documentation/main.css" />
		<link rel="stylesheet" href="../../../../../../styles/dbm/documentation/class.css" />

Dbm documentation

						Index

						<form action="https://www.google.co.uk/cse/publicurl" method="GET">
							<input type="hidden" name="cx" value="006746230495882673940:ilr36kbyhjo" />
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CreateBezierCurveFromPoints2d

dbm.core.globalobjects.curveevaluator.creators.CreateBezierCurveFromPoints2d

BaseObject

Creates curve that passes through a set of points.

Subclasses

Class has no subclasses.

Dependencies

EquationSolver

Import code

var CreateBezierCurveFromPoints2d = dbm.importClass("dbm.core.globalobjects.curveevaluator.creators.CreateBezierCurveFromPoints2d");

Full code

dbm.registerClass("dbm.core.globalobjects.curveevaluator.creators.CreateBezierCurveFromPoints2d", "dbm.core.BaseObject", function(objectFunctions, staticFunctions, ClassReference) {
	//console.log("dbm.core.globalobjects.curveevaluator.creators.CreateBezierCurveFromPoints2d");

	var EquationSolver = dbm.importClass("dbm.utils.math.EquationSolver");

	/**
	 * Constructor
	 */
	objectFunctions._init = function() {
		//console.log("dbm.core.globalobjects.curveevaluator.creators.CreateBezierCurveFromPoints2d::_init");

		this.superCall();

		return this;
	}; //End function CreateBezierCurveFromPoints2d

	/**
	 * Creates the curve.
	 *
	 * @param	aPointsArray	The points that defines how the curve should be created.
	 * @param	aReturnCurve	The curve that gets the new values.
	 * @param	aParameters		The array with parameters for the different points.
	 */
	objectFunctions.createCurve = function(aPointsArray, aReturnCurve, aParameters) {
		//console.log("dbm.core.globalobjects.curveevaluator.creators.CreateBezierCurveFromPoints2d::createCurve");
		//console.log(aPointsArray, aReturnCurve, aParameters);
		var curveDegree = aPointsArray.length-1;
		var multipliersArray = dbm.singletons.dbmCurveEvaluator.getBezierMultipliersArray(curveDegree);

		var arrayLength = aPointsArray.length;

		var eliminationArray = new Array(arrayLength);
		var currentArray = eliminationArray;
		var theLength = currentArray.length;
		for(var i = 0; i < theLength; i++) {
			var currentArray2 = new Array(arrayLength+2);
			currentArray[i] = currentArray2;
			var parameter = aParameters[i];
			for(var j = 0; j < arrayLength; j++) {
				currentArray2[j] = multipliersArray[j]*dbm.singletons.dbmCurveEvaluator.calculateBernsteinPolynomialWithoutMultiplier(parameter, j, curveDegree);
			}

			var startBpValue = Math.pow((1-parameter), curveDegree);
			var endBpValue = Math.pow(parameter, curveDegree);
			var currentPoint = aPointsArray[i];
			currentArray2[arrayLength+0] = currentPoint.x;
			currentArray2[arrayLength+1] = currentPoint.y;
		}

		EquationSolver.solveEquation(eliminationArray);

		for(var i = 0; i < theLength; i++) {
			var currentPoint = aReturnCurve.pointsArray[i];
			var currentArray2 = eliminationArray[i];
			currentPoint.x = currentArray2[arrayLength+0];
			currentPoint.y = currentArray2[arrayLength+1];
		}
	};
})

Local variables

Local functions

					_init():self

Constructor

Arguments

Function has no arguments

Return value

Self. Function is linkable.

Full code

objectFunctions._init = function() {
		//console.log("dbm.core.globalobjects.curveevaluator.creators.CreateBezierCurveFromPoints2d::_init");

		this.superCall();

		return this;
	}

					createCurve(aPointsArray, aReturnCurve, aParameters):void

Creates the curve.

Arguments

aPointsArray - The points that defines how the curve should be created.

aReturnCurve - The curve that gets the new values.

aParameters - The array with parameters for the different points.

Return value

Function has no return value.

Full code

objectFunctions.createCurve = function(aPointsArray, aReturnCurve, aParameters) {
		//console.log("dbm.core.globalobjects.curveevaluator.creators.CreateBezierCurveFromPoints2d::createCurve");
		//console.log(aPointsArray, aReturnCurve, aParameters);
		var curveDegree = aPointsArray.length-1;
		var multipliersArray = dbm.singletons.dbmCurveEvaluator.getBezierMultipliersArray(curveDegree);

		var arrayLength = aPointsArray.length;

		var eliminationArray = new Array(arrayLength);
		var currentArray = eliminationArray;
		var theLength = currentArray.length;
		for(var i = 0; i < theLength; i++) {
			var currentArray2 = new Array(arrayLength+2);
			currentArray[i] = currentArray2;
			var parameter = aParameters[i];
			for(var j = 0; j < arrayLength; j++) {
				currentArray2[j] = multipliersArray[j]*dbm.singletons.dbmCurveEvaluator.calculateBernsteinPolynomialWithoutMultiplier(parameter, j, curveDegree);
			}

			var startBpValue = Math.pow((1-parameter), curveDegree);
			var endBpValue = Math.pow(parameter, curveDegree);
			var currentPoint = aPointsArray[i];
			currentArray2[arrayLength+0] = currentPoint.x;
			currentArray2[arrayLength+1] = currentPoint.y;
		}

		EquationSolver.solveEquation(eliminationArray);

		for(var i = 0; i < theLength; i++) {
			var currentPoint = aReturnCurve.pointsArray[i];
			var currentArray2 = eliminationArray[i];
			currentPoint.x = currentArray2[arrayLength+0];
			currentPoint.y = currentArray2[arrayLength+1];
		}
	}

Static variables

Static functions

				Documentation exported with dbm.

redpajama_set_name: RedPajamaGithub


Next to the Paid user group, click the Manage link.
In the Manage menu, click Users.
This will display all the users who are a paid member of your forum.
If there is no Paid user group visible, ensure that you have Paid Access enabled in the Settings -> Paid Access section.
You can also visit your PayPal account and view the users from whom you have received a payment.


The fact that both powder and crack cocaine remain among the most available, popular and abused drugs in Pennsylvania indicates an urgent need for effective drug and alcohol education along with effective inpatient rehab.
In 2007, 739 kilograms of cocaine was seized by Federal agencies in Pennsylvania. The easy availability and high addictive qualities of these drugs not only ruin the lives of those who are addicted, but also those who love and care for them. Narconon Arrowhead has an effective inpatient drug and alcohol rehab with a 70% success rate along with drug education to over 65,000 youth about the realities and consequences of drugs and alcohol.
Approximately 64% of all new inmates admitted to the Pennsylvania Dept. of Corrections are AOD (alcohol and other drug) dependent. Philadelphia has created organizations to help with the drug epidemic with the establishment of programs such as High Intensity Drug Trafficking Area, Drug-Free Pennsylvania, Media Partnership and Drugs Don't Work Here. These are not rehabilitation facilities; they are preventative measures to stop a person traveling down the road of addiction. For a person already caught in the cycle of addiction, inpatient rehab is the answer for that person to regain a drug-free, productive, responsible, ethical and happy life.


Q. I understand that you do not ship material to an international address. How can I obtain documentation for a country other than the USA and Canada?
A. We suggest contacting a Volvo retailer in your area for information available in your market. You can also try Volvo Car Corporation's technical bookstore at www.volvocarstechinfo.ford.com/vss/.
Q. I am interested in purchasing a set of shop manuals for my 1996 Volvo 850. It seems that the only way to order this is item by item. Is that correct? Have I overlooked the location by which I might order a book or binder than contains most, if not all of the shop information? Please provide some guidance or direction.
A. Volvo does not carry sets for individual years and models. Sets are available by series only. You are correct, if you would like to purchase manuals for one year and model only, you would have to purchase the manuals individually.
Q. Do you carry information on the audio system in my Volvo?
A. Your vehicle's owner's manual covers all operational features of your audio system. Volvo service manuals and/or VIDA service information, in Group 39: Electrical, provide some information for diagnosing audio system faults. Volvo wiring diagrams provide information about wiring to and from the audio system. Volvo Service Bulletins and Tech-NET Notes may provide additional guidance about audio system diagnostics.
Q. Can I buy a yearbook set of service information for my Volvo?
A. The yearbook set is only available for the 800 series vehicles and can be found under the "STORE" then "Service/Parts Literature" on our website.
Q. I have been having trouble getting my Volvo repaired. I've taken it to three different shops. Can you help?
A. We are sympathetic to your situation. However, this is only a bookstore. We are not a technical hotline or a customer service center, and we have no special expertise to help in either area.
1. For help with a technical question, we ask you to contact a qualified Volvo retailer for advice, diagnostics, or repair.
We hope this is sufficient. If you can think of any other way in which we at the bookstore can be of help, please let us know.
Q. I understand that most of your service and parts documentation is not available in a printed format after 1998. How can I obtain recent literature?
A. Beginning in model year 1999, most service manuals moved from paper format to a fully electronic environment called VIDA. To find out more about VIDA click on the "Subscriptions" link.
All available service bulletins (and other bulletin types) for your vehicle are listed in "Subscriptions" area of the website. In this area you can order a subscription to all of the bulletins in the database of a certain type (e.g. service bulletins or SDS). You can also order a PDF version of specific wiring diagrams in the "Subscriptions" area.
In the "Service/Parts Literature" area you can order a PDF of a specific document.
Q. How are the service manuals indexed?
A. The following can be used as a general index to the service literature listed on the website. Please remember that when looking for literature for your particular vehicle, not all groups are active for all sections. Some groups are reserved for future expansion.
Single digits are Sections, double digits are Groups.
Q. I am looking for information pertaining to recall campaign 32 for my 1977 245. Could you please tell me what this campaign covered?
A. Use the "Search" feature on our website. Enter Text (keyword) you want to search on. Then click on the "Model" menu and select your model. Then click on the "Year" menu and select the year. In this case selecting "campaign" 240, and 1977 returns a list of items including "Service Campaign #32." You can order a copy of this campaign on the website by selecting either "PDF" or "Printed" then completing your purchase.


Chinese architecture practice Arch Studio developed the project of a minimalist Buddhist shrine, providing an immersive experience of being close to nature.
'Waterside Buddhist Shrine' is located in the forest near Tangshan, Hebei, China. The main assumption of the project was to create a peaceful space that would stand in harmony with nature. Adapted to the method of earthing, the building is hidden under the earth mound, making it close to nature without intervening into it. The serene space features meditation room, tea room, living room and bathroom. Its unique positioning, as well as peaceful interior provide an outstanding space for contemplation and meditation.
A Spiralling Ribbon Chapel By Hiroshi Nakamura & NAP Co.


text:
package iso9660

import (
	"os"
	"testing"
)

func TestIso9660ReadDirectory(t *testing.T) {
	// will use the file.iso fixture to test an actual directory
	// \ (root directory) should be in one block
	// \FOO should be in multiple blocks
	file, err := os.Open(ISO9660File)
	if err != nil {
		t.Fatalf("could not open file %s to read: %v", ISO9660File, err)
	}
	defer file.Close()
	// FileSystem implements the FileSystem interface
	pathTable, _, _, err := get9660PathTable()
	if err != nil {
		t.Fatalf("could not get path table: %v", err)
	}
	fs := &FileSystem{
		workspace: "", // we only ever call readDirectory with no workspace
		size:      ISO9660Size,
		start:     0,
		file:      file,
		blocksize: 2048,
		pathTable: pathTable,
	}
	//nolint:dogsled // we do not care about too many underbar here
	validDe, _, _, _, err := get9660DirectoryEntries(fs)
	if err != nil {
		t.Fatalf("unable to read valid directory entries: %v", err)
	}
	validDeExtended, _, _, err := getValidDirectoryEntriesExtended(fs)
	if err != nil {
		t.Fatalf("unable to read valid directory entries extended: %v", err)
	}
	fs.rootDir = validDe[0] // validDe contains root directory entries, first one is the root itself

	tests := []struct {
		path    string
		entries []*directoryEntry
	}{
		{`\`, validDe},
		{"/", validDe},
		{`\FOO`, validDeExtended},
		{`/FOO`, validDeExtended},
	}
	for _, tt := range tests {
		entries, err := fs.readDirectory(tt.path)
		switch {
		case err != nil:
			t.Errorf("fs.readDirectory(%s): unexpected nil error: %v", tt.path, err)
		case len(entries) != len(tt.entries):
			t.Errorf("fs.readDirectory(%s): number of entries do not match, actual %d expected %d", tt.path, len(entries), len(tt.entries))
		default:
			for i, entry := range entries {
				if diff := compareDirectoryEntries(entry, tt.entries[i], false); diff != nil {
					t.Errorf("fs.readDirectory(%s) %d: entries do not match", tt.path, i)
					t.Log(diff)
				}
			}
		}
	}
}

func TestRockRidgeReadDirectory(t *testing.T) {
	// will use the file.iso fixture to test an actual directory
	// \ (root directory) should be in one block
	// \FOO should be in multiple blocks
	file, err := os.Open(RockRidgeFile)
	if err != nil {
		t.Fatalf("could not open file %s to read: %v", RockRidgeFile, err)
	}
	defer file.Close()
	// FileSystem implements the FileSystem interface
	pathTable, _, _, err := getRockRidgePathTable()
	if err != nil {
		t.Fatalf("could not get path table: %v", err)
	}
	fs := &FileSystem{
		workspace:      "", // we only ever call readDirectory with no workspace
		size:           ISO9660Size,
		start:          0,
		file:           file,
		blocksize:      2048,
		pathTable:      pathTable,
		suspEnabled:    true,
		suspExtensions: []suspExtension{getRockRidgeExtension("RRIP_1991A")},
	}
	//nolint:dogsled // we do not care about too many underbar here
	validDe, _, _, _, err := getRockRidgeDirectoryEntries(fs, false)
	if err != nil {
		t.Fatalf("unable to read valid directory entries: %v", err)
	}
	fs.rootDir = validDe[0] // validDe contains root directory entries, first one is the root itself

	tests := []struct {
		path    string
		entries []*directoryEntry
	}{
		{`\`, validDe},
		{"/", validDe},
	}
	for _, tt := range tests {
		entries, err := fs.readDirectory(tt.path)
		switch {
		case err != nil:
			t.Errorf("fs.readDirectory(%s): unexpected nil error: %v", tt.path, err)
		case len(entries) != len(tt.entries):
			t.Errorf("fs.readDirectory(%s): number of entries do not match, actual %d expected %d", tt.path, len(entries), len(tt.entries))
		default:
			for i, entry := range entries {
				if diff := compareDirectoryEntries(entry, tt.entries[i], false); diff != nil {
					t.Errorf("fs.readDirectory(%s) %d %s: entries do not match", tt.path, i, entry.filename)
					t.Log(diff)
				}
			}
		}
	}
}

func TestLabel(t *testing.T) {
	t.Run("no primary volume descriptor", func(t *testing.T) {
		expected := ""
		fs := FileSystem{}
		label := fs.Label()
		if label != expected {
			t.Errorf("mismatched labels, actual '%s' expected '%s'", label, expected)
		}
	})
	t.Run("primary volume descriptor no label", func(t *testing.T) {
		expected := ""
		fs := FileSystem{
			volumes: volumeDescriptors{
				primary: &primaryVolumeDescriptor{},
			},
		}
		label := fs.Label()
		if label != expected {
			t.Errorf("mismatched labels, actual '%s' expected '%s'", label, expected)
		}
	})
	t.Run("primary volume descriptor with label", func(t *testing.T) {
		expected := "myisolabel"
		fs := FileSystem{
			volumes: volumeDescriptors{
				primary: &primaryVolumeDescriptor{
					volumeIdentifier: expected,
				},
			},
		}
		label := fs.Label()
		if label != expected {
			t.Errorf("mismatched labels, actual '%s' expected '%s'", label, expected)
		}
	})
}


text:
Q: How to make static nested SELECT faster I have a query similar to this
FROM products AS p, ..
LEFT JOIN ( SELECT .. ) AS popularity on popularity.products_id = p.products_id
LEFT JOIN ( SELECT .. ) AS reviews on reviews.products_id = p.products_id
WHERE..
AND..
..

The nested SELECTs from the LEFT JOIN are static, I mean the returned result is not influenced by external values. Those two SELECTs use data from within the db and calculate a result. The results of these queries change rarely, when some user makes a review for a product for example.
The problem is that these SELECTs take a lot of time to complete, they go through each row of their respective tables.
Is there a way I could make this query faster by transforming it into several smaller queries? Or caching the nested selects in some way?

A: I agree it's hard to answer without more information. However, check out this post: http://www.xaprb.com/blog/2006/04/30/how-to-optimize-subqueries-and-joins-in-mysql. I've found it quite helpful in the past.
If you look at the very last paragraph, you'll see a technique for saving results of the nested selects in a temporary table.

A: You may want to add some indices to the tables which are used in your subselect statements, with the right indexing a database should be able to return resultsets from millions of rows pretty much instantly.

redpajama_set_name: RedPajamaStackExchange


text:
Home»Public Health Agencies»US Department of Agriculture»FSIS Issues Public Health Alert for Ready-To-Eat Hy-Vee Beef Pot Roast Entrée Products due to Misbranding and an Undeclared Allergen
FSIS Issues Public Health Alert for Ready-To-Eat Hy-Vee Beef Pot Roast Entrée Products due to Misbranding and an Undeclared Allergen
By foodpoisoningnews January 19, 2023 Updated: January 19, 2023 No Comments3 Mins Read
WASHINGTON, Jan. 19, 2023 – The U.S. Department of Agriculture's Food Safety and Inspection Service (FSIS) is issuing a public health alert due to concerns that the gravy component of ready-to-eat Hy-Vee beef pot roast entrée products may contain wheat, a known allergen, which is not declared on the finished product label. FSIS is issuing this public health alert to ensure that consumers with an allergy to wheat are aware that these products should not be consumed. A recall was not requested because the products are no longer available for purchase.
The beef pot roast entrée products were produced on various dates between December 26, 2022 and January 17, 2023. The following products are subject to the public health alert [view labels]:
11.6 oz. plastic containers containing "HyVee mealtime BEEF POT ROAST DINNER" with Best If Use By dates of 01/03/2023 – 01/24/2023 and lot codes of 22361-23017.
25.5 oz. plastic containers containing "HyVee mealtime BEEF POT ROAST DINNER" with Best If Used By dates of 01/02/2023 – 01/24/2023 and lot codes of 22360-23016.
The products bear establishment number "EST. 51558" inside the USDA mark of inspection. These items were shipped to retail locations in Illinois, Iowa, Kansas, Minnesota, Missouri, Nebraska, South Dakota, and Wisconsin.
The problem was discovered when the establishment identified that they received a substitute gravy mix from their spice supplier that includes wheat, whereas the normal gravy mix does not. The establishment notified FSIS that the label on the back of the product does not list wheat contained in the substitute gravy mix.
There have been no confirmed reports of adverse reactions due to consumption of these products. Anyone concerned about an illness should contact a health care provider.
FSIS is concerned that some products may be in consumers' refrigerators or freezers. Consumers with a wheat allergy who have purchased these products are urged not to consume them. These products should be thrown away or returned to the place of purchase.
Consumers and members of the media with questions about the public health alert can contact Tina Potthoff, Senior Vice President of Communications of Hy-Vee, at 515-559-5770 and [email protected].
Consumers with food safety questions can call the toll-free USDA Meat and Poultry Hotline at 888-MPHotline (888-674-6854) or live chat via Ask USDA from 10 a.m. to 6 p.m. (Eastern Time) Monday through Friday. Consumers can also browse food safety messages at Ask USDA or send a question via email to [email protected]. For consumers that need to report a problem with a meat, poultry, or egg product, the online Electronic Consumer Complaint Monitoring System can be accessed 24 hours a day at https://foodcomplaint.fsis.usda.gov/eCCF/.
Daniele International LLC Recalls Ready-to-Eat Sausage Products Due to Possible Listeria Contamination
FSIS Issues Public Health Alert for Fully Cooked, Frozen Swai Fried Fish Cutlet Products Produced Without Benefit of Inspection
Morasch Meats Inc. Recalls Raw Frozen Diced Beef Products Due to Possible E. Coli O157:H7 Contamination


COSTES ECONÓMICOS DERIVADOS DE LA INTERVENCIÓN EN COMPLICACIONES DE PIE DIABÉTICO.
EVOLUCION Y TRATAMIENTO DEL PIE PLANO INFANTIL.CASO CLÍNICO.
LESIONES EN MIEMBRO INFERIOR ASOCIADAS A LA PRÁCTICA DEPORTIVA DE LA MARCHA ATLÉTICA EN LA PROVINCIA DE ALICANTE Y MURCIA.


text:
Tata Harrier Review
Find Vehicle Owner By Number
Ford Bronco 2021
Cars Under 10 lakhs
Road Tax in India
BSVI Mahindra Scorpio Could Launch In a Few Days
Mahindra will launch the BS6 compliant Scorpio in India as soon as the lockdown is over. The updated model will derive power from a 2.0-litre diesel unit.
Mahindra and Mahindra Limited have officially revealed the specs of the BS6 Scorpio. The carmaker will launch the updated model as soon as the lockdown is lifted. The new BS6 Mahindra Scorpio will be offered with a BS6-compliant 2.0-litre diesel motor that produces 140bhp of power at 3,750 rpm and 320 Nm of peak torque at 1,500-2,800 rpm. Transmission duties will be handled by a 5-speed manual gearbox and an optional 6-speed manual transmission. Previously, Mahindra was offering the Scorpio with three BS4 powertrain options.
The carmaker will launch the updated model as soon as the lockdown is lifted
The first engine option was a 2.5-litre oil burner, which puts out 75bhp of power at 3,200 rpm and 200 Nm of torque 1,400-2,200 rpm. The engine comes coupled to 5-speed manual gearbox. The second engine option was a 2.2-litre oil-burner, which develops 120bhp of peak power at 4,000 rpm and 280 Nm of twisting force at 1,800-2,800 rpm, paired with a 5-speed transmission.
The third engine option, which has been carried over in a BS6 state, is that of a 2.2-litre diesel mill which churns out 140bhp at 3,750 rpm and 320 Nm of torque at 1,500-2,800 rpm. The 2.2-litre diesel motor can be had with either a 5-speed manual or a 6-speed manual transmission. The carmaker has also re-arranged the variant line-up of the BS6 Scorpio. Mahindra has removed the entry-level S3 trim and offers the updated SUV with S5, S7, S9 and S 11 variants. Moreover, there are a few changes made in the new model.
Next-Gen Mahindra Scorpio Arriving in 2021
Mahindra has removed the entry-level S3 trim and offers the updated SUV with S5, S7, S9 and S 11 variants
The BS6 Mahindra Scorpio S5 variant now employs lead-me-to-vehicle headlamps, and the top-spec S11 trim misses out shift-on-fly 4WD system option. The carmaker will soon reveal the prices of the updated model. In other news, Mahindra has started road testing of the new-gen Scorpio. The SUV is scheduled to hit the Indian market by the first half of next year. The all-new model is expected to derive power from a 2.0-litre mHawk diesel unit and a 1.5-litre mStallion T-GDi petrol engine.


text:
BEACON Advanced Metering Analytics Improves Accuracy & Customer Service for Highland Village, Texas
From left to right: Todd Hutson, UT Supervisor, Kyle Hogue, P.E., Department Director of Public Works, Justin Praesel, UT Superintendent., DJ Johnson, Atlas Utility, Inc., Scott Kriston, Director of Public Works.
After deployment of an AMI system that did not work properly, initially forcing them to manually read meters, Highland Village was in need of a new vendor and product they could count on. Enter Badger Meter and the BEACON AMA managed solution, with ORION Cellular endpoints.
"Badger Meter came highly recommended by our trusted distributor, Atlas Utility Supply, and after learning about BEACON AMA, we knew this was the right option for us," said Scott Kriston, Director of Public Works.
Since Highland Village's water metering system was new, and only the endpoints were failing, the new endpoints needed to be field spliced to the existing encoders by a contractor. Installation began in August 2014 and was completed by late November.
"Considering the intricacies of the installation, it really went well and we were pleased with the responsiveness of everyone," Kriston said.
Accuracy Pays
Highland Village is about five sq miles in size, and has approximately 5600 services. When their original system was installed, the utility knew it would save time and money. However, when the endpoints quickly started to fail they found themselves back where they started.
"Since we couldn't replace the whole system again, it was important for us to find an endpoint that would be highly accurate and was compatible with our existing meters," Kriston said.
BEACON AMA has produced a consistent 99.7% accuracy rate for the utility. This was an immediate solution that combined ORION Cellular endpoints, use of existing cellular networks, and an easy- to-use software product to give the utility the fast, near real-time data it needed to start saving time and money. Now, instead of paying their staff to manually read meters, the utility is able to focus on its core competency, managing their water distribution system.
Will Norris, UT Technician 3, on location.
Improved Customer Service
BEACON AMA offers an interface that is easy to use for both the Highland Village utility department and its end water customers. By utilizing the BEACON AMA software suite, the utility can easily access and manage exact, near real-time data. This gives the utility a troubleshooting tool for any customer complaints or maintenance issues that may arise. Because the utility has access to data that is collected continuously, it can easily point to specific occurrences on the customer's water bill to help decipher where and how a discrepancy might have occurred. Customers can then work with the utility to fix any leaks or determine when their water use may have exceeded their expectations.
The conversion of reading data into proactive intelligence within BEACON AMA became a focal point in customer service for the city in 2015 when North Texas utilities were faced with massive consumer complaints due to high water bills. Texas has been undergoing severe drought for several years. However, in 2015 they had a very wet, cool spring and had heavy rains. Rivers and lakes flooded and reservoirs were filled, so utilities removed all watering restrictions. July and August were hot and dry, and with lawns lush for the first time in years, residents started irrigating at higher levels. They basically went from winter consumption levels in June, to full summer consumption levels in July – equaling as much as five times the winter consumption levels.
The dramatic change in usage meant high water bills and numerous complaints pouring in through local news stations, social media, email, and phone calls.
"We were so thankful to have all of the tools provided in BEACON AMA," Kriston said. "The graphs and reports proved some leaks, but mainly proved to customers that their consumption really increased during that time – justifying the higher bill. This data was especially helpful during a town hall meeting to show how all the systems were managed and it alleviated many concerns."
In addition, the EyeOnWater smartphone app, included as part of the BEACON AMA software suite, is being downloaded by the utility's customers.
"We started to advertise EyeOnWater in our customers' bills and newsletters, and it has really taken off," Kriston said. "It allows them to see the amount of water they are using and when they are using it – making it very easy for them to see their consumption with a touch of a button."
"With improved billing accuracy and systems in place to unlock the analytics behind the hourly reading data, the city anticipates BEACON AMA to keep providing operational improvements throughout the life of the system. The partnership between Badger Meter, Atlas Utility and Highland Village will ensure all of our mutual success," said DJ Johnson, Atlas Utility, Inc.
Highland Village Solution
BEACON Advanced Metering Analytics (AMA)
5,600 ORION Cellular endpoints
Meter reading efficiency
Automated systems enable staff to perform other tasks
More accurate data and time-saving solutions
Faster leak detection
More detailed usage information reduces billing disputes
EyeOnWater smartphone and tablet app makes data available to end water customers


text:
package object

import (
	"io"

	"github.com/go-git/go-git/v5/plumbing"
	"github.com/go-git/go-git/v5/plumbing/storer"
)

// NewFilterCommitIter returns a CommitIter that walks the commit history,
// starting at the passed commit and visiting its parents in Breadth-first order.
// The commits returned by the CommitIter will validate the passed CommitFilter.
// The history won't be transversed beyond a commit if isLimit is true for it.
// Each commit will be visited only once.
// If the commit history can not be traversed, or the Close() method is called,
// the CommitIter won't return more commits.
// If no isValid is passed, all ancestors of from commit will be valid.
// If no isLimit is limit, all ancestors of all commits will be visited.
func NewFilterCommitIter(
	from *Commit,
	isValid *CommitFilter,
	isLimit *CommitFilter,
) CommitIter {
	var validFilter CommitFilter
	if isValid == nil {
		validFilter = func(_ *Commit) bool {
			return true
		}
	} else {
		validFilter = *isValid
	}

	var limitFilter CommitFilter
	if isLimit == nil {
		limitFilter = func(_ *Commit) bool {
			return false
		}
	} else {
		limitFilter = *isLimit
	}

	return &filterCommitIter{
		isValid: validFilter,
		isLimit: limitFilter,
		visited: map[plumbing.Hash]struct{}{},
		queue:   []*Commit{from},
	}
}

// CommitFilter returns a boolean for the passed Commit
type CommitFilter func(*Commit) bool

// filterCommitIter implements CommitIter
type filterCommitIter struct {
	isValid CommitFilter
	isLimit CommitFilter
	visited map[plumbing.Hash]struct{}
	queue   []*Commit
	lastErr error
}

// Next returns the next commit of the CommitIter.
// It will return io.EOF if there are no more commits to visit,
// or an error if the history could not be traversed.
func (w *filterCommitIter) Next() (*Commit, error) {
	var commit *Commit
	var err error
	for {
		commit, err = w.popNewFromQueue()
		if err != nil {
			return nil, w.close(err)
		}

		w.visited[commit.Hash] = struct{}{}

		if !w.isLimit(commit) {
			err = w.addToQueue(commit.s, commit.ParentHashes...)
			if err != nil {
				return nil, w.close(err)
			}
		}

		if w.isValid(commit) {
			return commit, nil
		}
	}
}

// ForEach runs the passed callback over each Commit returned by the CommitIter
// until the callback returns an error or there is no more commits to traverse.
func (w *filterCommitIter) ForEach(cb func(*Commit) error) error {
	for {
		commit, err := w.Next()
		if err == io.EOF {
			break
		}

		if err != nil {
			return err
		}

		if err := cb(commit); err == storer.ErrStop {
			break
		} else if err != nil {
			return err
		}
	}

	return nil
}

// Error returns the error that caused that the CommitIter is no longer returning commits
func (w *filterCommitIter) Error() error {
	return w.lastErr
}

// Close closes the CommitIter
func (w *filterCommitIter) Close() {
	w.visited = map[plumbing.Hash]struct{}{}
	w.queue = []*Commit{}
	w.isLimit = nil
	w.isValid = nil
}

// close closes the CommitIter with an error
func (w *filterCommitIter) close(err error) error {
	w.Close()
	w.lastErr = err
	return err
}

// popNewFromQueue returns the first new commit from the internal fifo queue,
// or an io.EOF error if the queue is empty
func (w *filterCommitIter) popNewFromQueue() (*Commit, error) {
	var first *Commit
	for {
		if len(w.queue) == 0 {
			if w.lastErr != nil {
				return nil, w.lastErr
			}

			return nil, io.EOF
		}

		first = w.queue[0]
		w.queue = w.queue[1:]
		if _, ok := w.visited[first.Hash]; ok {
			continue
		}

		return first, nil
	}
}

// addToQueue adds the passed commits to the internal fifo queue if they weren't seen
// or returns an error if the passed hashes could not be used to get valid commits
func (w *filterCommitIter) addToQueue(
	store storer.EncodedObjectStorer,
	hashes ...plumbing.Hash,
) error {
	for _, hash := range hashes {
		if _, ok := w.visited[hash]; ok {
			continue
		}

		commit, err := GetCommit(store, hash)
		if err != nil {
			return err
		}

		w.queue = append(w.queue, commit)
	}

	return nil
}


text:
package com.newsblur.fragment;

import android.app.Activity;
import androidx.fragment.app.Fragment;

import com.newsblur.util.FeedUtils;

public class NbFragment extends Fragment {

    /**
     * Pokes the sync service to perform any pending sync actions.
     */
    protected void triggerSync() {
        Activity a = getActivity();
        if (a != null) {
            FeedUtils.triggerSync(a);
        }
	}

}


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I started singing lessons with Cathy two years ago, I have learned so much from Cathy i.e new breathing techniques or beating the pre-performance nerves!
Cathy's classes are never boring and she allows you to be confident in your abilities. She always tries her best to make everyone feel comfortable and does a lot of different genres of music from musical theatre to the latest pop music, she is always updating the set list!
I would highly recommend Cathy Vard's singing lessons as she allows you to really get the best from your abilities and to really shine!


text:
Q: Is timezone info redundant provided that UTC timestamp is available? I have a simple mobile app that schedules future events between people at a specified location. These events may be physical or virtual, so the time specified for the event may or may not be in the same timezone as the 'location' of the event. For example, a physical meeting may be scheduled for two people in London at local time 10am on a specified date. Alternatively, a Skype call may be scheduled for two people in different timezones at 4pm (in one person's timezone) on a specified date though the 'location' of the event is simply 'office' which means two different places in different timezones.
I wonder the following design is going to work for this application:

*

*On the client, it asks user to input the local date and time and specify the timezone local to the event.

*On the server, it converts the local date and time with the provided timezone into UTC timestamp, and store this timestamp only.

*When a client retrieves these details, it receives the UTC timestamp only and converts it into local time in the same timezone as the client's current timezone. The client's current timezone is determined by the current system timezone setting, which I think is automatically adjusted based on the client's location (of course, assuming the client is connected to a mobile network).
My main motivations for this design are:

*

*UTC is an absolute and universal time standard, and you can convert to/from it from/to any timezone.

*Users only care about the local date and time in the timezone they are currently in.
Is this a feasible design? If not, what specific scenarios would break the application or severely affect user experience? Critiques welcome.

A: For a single event, knowing the UTC instant on which it occurs is usually enough, so long as you have the right UTC instant (see later).
For repeated events, you need to know the time zone in which it repeats... not just the UTC offset, but the actual time zone. For example, if I schedule a weekly meeting at 5pm in Europe/London with colleagues in America/Los_Angeles, then for most of the year it will occur at 9am for them... but for a couple of weeks in the year it will occur at 8am and for a couple of weeks in the year it will occur at 10am, due to differences in when DST is observed.
Even for a single event, you might want to consider what happens if time zone rules change. Suppose I schedule a meeting for 4pm on March 20th 2018, in the Europe/London time zone. Currently that will occur with a UTC offset of 0... but suppose between now and the meeting, the time zone rules change to bring British Summer Time in one hour earlier. If I've written it in my diary as 4pm, I probably don't want the software to think that it's actually at 5pm because that's the UTC instant we originally predicted.
We don't know your exact application requirements, but the above situations at least provide an argument for potentially storing the local time and time zone instead of the UTC instant... but you'll also need to work out what to do if the local time ends up being skipped or being ambiguous due to DST changes. (When the clocks fall back, some local times occur twice. When the clocks skip forward, some local times are skipped. A time that was unambiguous may become invalid or ambiguous if the rules change between the original planning time and the actual event. You should probably account for this in your design.)

A: To keep it simple, my answers are:

*

*Timezone info is redundant if you want to define a single moment. A
UTC/Unix timestamp completely defines a moment.

*Your design seems feasible but on point 2: i would convert to the UTC/Unix timestamp on the client-side and already give this timestamp
in its final form to the server. Reason: the client-side already has the info necessary to convert (see this time-keeping
client-server-db
architecture
example - it works based exactly on the principles you describe).

*One possible problem (as described by Jon Skeet in his answer) are recurring events, but this should be reflected in the way you model
time. The difference between recurring events and fixed events is
that the latter completely define a moment (like a UTC/Unix
timestamp) while the first are only a 'function' which can be applied
to the current time to get the next trigger time of the recurring
event. But this might entirely be a different problem than what
you ask - in any case, somehow distinguishing between recurring
events (if you need them) and fixed events in your model is a good
idea.

*One decision to make is: PULL or PUSH? Or both? Do you want the server to be able to send emails for example, when an event comes to
pass? Or do you want client-side alerts only when your client-side
app is running? The answers to these questions will help you come
towards a design suitable for you.