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Quebec manufacturing, construction sectors warn against new COVID-19 lockdowns
Province may order 'non-essential' manufacturers and the construction sector to close, extend school closures today
By Jacob Serebrin
MONTREAL — Quebec's manufacturing and construction associations say there will be major damage to Quebec's economy if the government imposes a strict COVID-19 lockdown similar to what occurred last spring.
Veronique Proulx, CEO of Manufacturiers et Exportateurs du Quebec, reacted Tuesday to multiple media reports saying Premier Francois Legault is set to close non-essential manufacturing businesses to help stop the spread of COVID-19.
"The worst scenario for us would be to go back to the same situation we had last spring," Proulx said in an interview.
She said Quebec manufacturers lost $4 billion in sales when they were shut during the first wave of the pandemic and she expects a similar situation if manufacturers are forced to close again.
Legault is scheduled to hold a news conference late Wednesday and was meeting with opposition leaders Tuesday.
According to multiple reports, the province may, for the first time since the spring, order "non-essential" manufacturers and the construction sector to close and extend the current closure of schools.
Quebec reported 2,508 new COVID-19 cases Tuesday and 62 more deaths, including 17 that occurred in the previous 24 hours. Health officials said COVID-19 hospitalizations rose by 23, to 1,317 — the highest number since late May — and 194 people were in intensive care, an increase of six.
The province says 2,529 doses of vaccine were administered Monday, for a total of 32,763. The test positivity rate in Quebec was 11 per cent on Jan. 3, the most recent date for which data is available, with 20,716 tests conducted.
Quebec has reported 215,358 cases of COVID-19 and 8,441 deaths linked to the virus since the beginning of the pandemic.
Local industry at disadvantage
Proulx said that if Quebec were the only jurisdiction in North America to order factories to close, it would put the province's manufacturing industry — which employs 450,000 people and accounts for 14 per cent of the provincial GDP — at a severe disadvantage.
"If we're shutting down and consumers continue to buy, as they did during the last shutdown, they'll be buying from Amazon and they'll be buying from other manufacturers who can actually continue to produce," she said.
"The market share that these foreign companies are gaining is there to stay; it's very difficult for Quebec manufacturers to win them back."
Proulx said manufacturers have put measures in place to prevent the transmission of COVID-19, adding that while there may be room for stricter rules in some parts of the industry, she said hasn't seen the data that supports shutting down the whole sector.
About 27 per cent of active COVID-19 outbreaks in Quebec workplaces were identified in the manufacturing industry during the week ending Dec. 19, according to the most recent government data. Those outbreaks were tied to 1,336 infections out of a total of 3,367 infections linked to active workplace outbreaks that week.
Retail stores accounted for about 22 per cent of workplace outbreaks during the same period, while the construction sector was responsible for about 9 per cent.
Safety measures working: spokesman
Guillaume Houle, spokesman the Association de la construction du Quebec, said Tuesday his organization wants the government to keep construction sites open.
He said the small number of outbreaks in his industry — which employs about half a million people in Quebec — suggests the measures currently in place are working. Houle, however, said the industry is open to having new discussions with health officials and unions about stricter measures that would allow sites to stay open.
With construction contributing around $1 billion to Quebec's GDP every week, Houle said the economic cost of another shutdown would be "unprecedented."
But Eric Boisjoly, director general of the construction wing of one of Quebec's main labour federations, said measures to stop the spread of COVID-19 on work sites aren't being enforced as much as they were when the industry reopened in the spring. He said the problem is more acute on smaller sites.
Workers, however, won't be happy if construction sites are closed, he added. One of the big challenges, he explained, is uncertainty, because workers don't know what kind of support will be available if they aren't able to work.
Karl Blackburn, the president and CEO of Quebec's largest employer group, the Conseil du patonat du Quebec, said his organization wants the government to take a more targeted approach.
He'd like to see the government identify specific problem areas and use a "surgical" approach to deal with the spread of COVID-19 in those sectors.
That would avoid the need for a full lockdown that could be "catastrophic" for Quebec's economy, he said.
Blackburn said he'd also like to see stricter sanctions for people and organizations that don't follow public health rules.
Lawsuit to challenge Quebec back-to-school plan requiring in-person attendance
Legault, Ford meet in Mississauga, Ont., to discuss economic recovery
Quebec orders all non-essential businesses closed from Dec. 25 until at least Jan. 11
Ontario-wide lockdown set to begin Dec. 26
Ontario parents finding ways to manage extended online learning
Tips for employers if political extremism creeps into Canada
U.S. company offers to pay employees to get COVID-19 vaccine
FBI warns of plans for nationwide armed protests in U.S. next week
New COVID-19 obligations in place for Toronto workplaces
Shopify to hire 2,021 technical staff this year; workers can be located anywhere
Talent Canada@TalentCanadaMag·
Ottawa temporarily lifted restrictions on international students' work hours last April to ease the staffing crunch in health care and other essential workplaces. The measure expired Aug. 31, and has not been reinstated. #CDNpoli
https://www.talentcanada.ca/international-students-frustrated-by-federal-work-limits-during-pandemic/
Parents who have to juggle supervising kids and working — either in or out of the home — are being stretched thin in southern Ontario. #RemoteWork #COVID19
https://www.talentcanada.ca/ontario-parents-find-ways-to-manage-extended-online-learning/
OHS Canada@OHSCanada·
The Alberta government is easing public-health rules around funerals, outdoor gatherings and hair salons while warning residents to keep following other restrictions in place to limit the spread of COVID-19. #ABpoli
https://www.ohscanada.com/alberta-to-ease-some-covid-19-rules-next-week-as-a-test/
After months of "abnormal" economic uncertainty, early projections for 2021 show Canadian employers are beginning to relax cost-cutting measures in place because of the coronavirus pandemic. #Compensation
https://www.talentcanada.ca/pandemic-related-wage-freezes-expected-to-thaw-this-year/
Onlookers looked on in horror Jan. 6 as protesters smashed windows, scaled walls and mobbed the U.S. Capitol. The violent outbursts provided lessons for employers on incivility and off-duty misconduct. With comments from @civilityatwork & @williamshrlaw.
https://www.talentcanada.ca/tips-for-employers-if-political-extremism-creeps-into-canada/


Follow these home fire safety tips to help make sure your home and family are safe from potential fires.
Every 85 seconds. That's how often fire departments responded to a house fire in 2013, according to the National Fire Protection Association. The tragic part is that most fires are preventable. Because October is Fire Prevention Month, we want to make sure you're prepared to keep the worst from happening. From formulating an action plan to simple fire prevention tips, here's how to create a fire safety plan to help protect your family from a potentially deadly household emergency — home fires.
Regular maintenance on your appliance can help identify fire risks before they happen.
Make sure to check the test button on your smoke and CO detectors every month and replace the batteries at least once a year. Also make sure to install a smoke detector on each level of your house, including the basement. You can even buy CO detectors, combination smoke/CO detectors and fire extinguishers right from a Sears Blue Service Crew® technician.
Have an expert conduct a preventive maintenance assessment of your home's heating and cooling systems every year. This will help ensure that your heating and cooling systems are properly installed. Heating and cooling equipment fires constitute the second largest share of residential fires, after cooking equipment, according to the Consumer Product Safety Commission. If you have a Sears Masters Protection Agreement or a Repair Protection Agreement on your home's HVAC systems, an annual preventive maintenance check from a Sears Home Services technician is included. See your agreement's terms and conditions for more information.
When you're cooking, never leave a stove unattended. Make sure to turn cookware handles toward the back of the stove, so that young children can't accidentally knock over a boiling pot. Also use heat-resistant oven mitts to handle hot cookware. In the event of a grease spill, be sure to clean up any grease residue as soon as it's cool enough because it can easily catch fire. If a grease fire ignites, don't put it out with water — that could cause it to splash out and spread. Instead, shut off the flame and cover the fire with the lid of a pan. Cutting off the air supply allows the fire to die out. It's also a good idea to keep a fire extinguisher that's made especially for grease fires in your kitchen.
Dryer lint that accumulates in your dryer's removable filter is flammable. If the lint isn't removed on a regular basis, it can cause a fire. Also check for and remove lint buildup around the dryer's exhaust hose at least once a year. If you want a professional to do the job, schedule a clothes dryer vent cleaning appointment.
If the plastic casing around your power cords is cracked or damaged, it could lead to electrical sparks that could cause a fire if the cord is in use. Replace any power cords or appliance cords that are damaged before using them again.
"Also, make sure that you don't have too many appliances plugged into one outlet," Brown says. "That could overload a circuit and potentially lead to a fire." This can be prevented by streamlining how many appliances are plugged into an outlet and making sure the combination of appliances plugged in doesn't exceed the outlet's amperage rating, Brown says.
Another cause of home fires is electrical arcing, which is an electrical discharge that develops in a gap between two electrodes. This can break down the insulation of a wire and cause an electrical fire. Older or faulty wiring can be prone to this. Installing an arc-fault circuit interrupter will reduce the chance of electrical fire because the circuit interrupter will sense a quick electrical surge from an arc and cut the power.
According to the U.S. Fire Administration, another important aspect to helping keep your family safe in the event of a fire is to create an escape plan so everyone can exit your home as safely as possible.
Develop a fire escape plan for your family to follow in the event of an emergency. Have all family members practice opening windows, unlocking screens and unlatching quick-release latches on security bars so they'll be familiar with how to unlock and remove everything in an emergency.
During your family's practice drill, let family members become familiar with feeling closed doors and door handles with the back of their hand before opening a door. Tell them that if a door feels hot, use their alternate escape route.
During their escape prep, have family members practice staying close to the ground, where smoke will be less dense. And tell everyone to keep their hands over their mouth in an actual fire emergency to help reduce smoke inhalation. Once everyone's safely out of the home, have them gather in a designated spot. In case of an actual emergency, they should not go back into the home for any reason.
Sears Home Services Helps Rebuild a Community Keep Dryer Vents Free From Blockage QUIZ: What Exterior Home Improvement Trend Should You Try?


Pregnancy inspired this post! Matthew and I love having the Smoky Mountains in our backyard and going for a drive or a hike through them is one of our very favorite things to do. However, it just isn't in the cards for us this Fall! Being 8 months pregnant isn't ideal for hiking or even car riding shape (too many bathroom stops)! So I decided to "hike from home"! I've been exploring the mountains from our living room and wanted to invite you to do the same thing from wherever you are today. I think it will be good for our souls to take a mental break and appreciate God's glorious creation, don't you?


I was watching the news this weekend and I saw Michael Ignatieff in a Montreal bagel shop shaking hands with possible supporters. One guy politely said to him, "Unfortunately I'll be voting for the NDP candidate." To say something like this is extremely bad etiquette. If you ever run into Iggy while he's out campaigning what you should say is, "I'll be voting either Tory, NDP, Bloc, Green, Christian Heritage, Marxist-Lenninist, Rhino, Walrus..." And, as he starts to walk away, yell: "If you were the only name on the ballot I'd still find a way not to vote for you!"


Marcy Reed here with some reflections on GSUSA's 52nd Convention held in Houston last week. While there was much celebration of the first 100 years of Girl Scouts, with many inspirational speakers – both girls and adults – recounting what scouting has meant in their lives, we spent much of our time looking forward because that's what Girl Scouts do – we shape the future. I'm excited about 2012 being named "The Year of the Girl" because after all isn't that what it's all about?! Stay tuned for more reflections from the delegates, staff, and other volunteers who attended convention. I am Marcy Reed and I am a Girl Scout!
Convention Highlights – Girl Scouts make new friends!
CREATE Your Girl Scout eBiz Account NOW and see what it can do for YOU!


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Home / MOVIE REVIEWS / "Nerve" Movie Review: A Whole New Social Media Movie Experience
"Nerve" Movie Review: A Whole New Social Media Movie Experience
ekmanalaysay 8:44:00 PM MOVIE REVIEWS
What would you do if you enter in a social media "dare game"? Are you just going to be a "Watcher" or a "Player"?
"Nerve" is perhaps one of the original movies this season that tackles about the social media fandom of today's youth. But the use of social media in this movie is taken to a higher level for more realistic feel and immersion rather than just typing with 140 characters or posting online using different social media platforms.
"Nerve" is an intelligent film with the feels that of "Big Brother" TV show, where someone or everybody is watching you and the intimate feels of playing "Truth or Dare" minus the "truth" thingie. This movie should be watched by people who are social media addicts or those who love to post anything online to limit their use of this millennial technology.
Emma Roberts' performance is such a closet teenybopper young adult --- strong but shy, silent but loud, and beautiful but a damsel in distress. On the other hand, Dave Franco's performance is a perfect match for Emma Roberts' character. He is outgoing, independent, and a free-spirited soul with hidden agenda. It's always the mystery that puts on the character of a person, and Dave Franco's performance simply nailed it. Acting-wise we can forgive them because Emma Roberts and Dave Franco were such an eye candy in the film.
The story is quite interesting that we got hooked as the movie progresses. There is also this romantic-comedy feels as you watch the film. Aside from these, you can also experience the reality as the audience are immersed into what's happening in the "Nerve" social media dare game as the dares come to different levels of difficulty.
Overall, "Nerve" gave us the right entertainment for something new and different but is familiar to everyone else. It has levels of intensity, drama, excitement, and mixed feelings that every moviegoers love, just like what we did! An 8 out of 10 stars for the immersive techniques and entertainment value. Watch "Nerve" movie trailer below. Enjoy!

redpajama_set_name: RedPajamaCommonCrawl


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LuaJIT

Portability Requirements for Coco

Index

LuaJIT

Features

Installation

Running

API Extensions

Introduction

Performance

Debugging

Changes

Coco

Portability

API Extensions

Changes

DynASM

Features

Examples

Download »

Coco needs some machine-specific features which are
inherently non-portable. Although the coverage is pretty good,
this means that Coco will probably never be a standard part
of the Lua core (which is pure ANSI C).

Context Switching Methods

Coco relies on four different machine-specific methods
for allocating a C stack and switching context.
The appropriate method is automatically selected at compile time.

GCC Inline Assembler

This method is only available when GCC 3.x/4.x is used
to compile the source.
This is the fastest method for context switching, but only available
for a few CPUs (see below).

Modified setjmp Buffer

This method changes a few fields in the setjmp buffer to
redirect the next longjmp to a new function with a new stack
frame. It needs a bit of guesswork and lots of #ifdef's to
handle the supported CPU/OS combinations, but this is quite
manageable.

This is the fallback method if inline assembler is not available.
It's pretty fast because it doesn't have to save or restore signals
(which is slow and generally undesirable for Lua coroutines).

POSIX ucontext

The POSIX calls getcontext, makecontext and switchcontext
are used to set up and switch between different C stacks.
Although highly portable and even available for some
esoteric platforms, it's slower than the setjmp method
because it saves and restores signals, too (using at least one
syscall for each context switch).

You can force the use of ucontext (instead of setjmp) by enabling
<tt>-DCOCO_USE_UCONTEXT</tt> in <tt>src/Makefile</tt>.

Windows Fibers

This is the standard method to set up and switch between
different C stacks on Windows. It's available on Windows 98
and later.

None of the other methods work for Windows because OS specific code
is required to switch exception handling contexts.

Supported Platforms

Coco has support for the following platforms:

CPU
System
Method

x86	(any OS)	gccasm

x86	Linux	setjmp

x86	FreeBSD	setjmp

x86	NetBSD	setjmp

x86	OpenBSD	setjmp

x86	Solaris	setjmp

x86	Mac OS X	setjmp

x64	(any OS)	gccasm

x64	Solaris	setjmp

MIPS32	(any OS)	gccasm

MIPS32	Linux	setjmp

ARM	Linux	setjmp

PPC32	Mac OS X	setjmp

(any CPU)	POSIX	ucontext

(any CPU)	Windows	fibers

It should work pretty much anywhere where a correct
POSIX ucontext implementation is available. It has been tested
on every systems I could get hold of (e.g. Sparc, PPC32/PPC64,
IA64, Alpha, HPPA with various operating systems).

Caveats

Some older operating systems may have defective ucontext
implementations because this feature is not widely used. E.g. some
implementations don't mix well with other C library functions
like <tt>malloc()</tt> or with native threads.
This is really not the fault of Coco — please upgrade your OS.

Note for Windows: Please read the explanation for the default
» Thread Stack Size
in case you want to create large numbers of Fiber-based coroutines.

Note for MinGW/Cygwin: Older releases of GCC (before 4.0) generate
wrong unwind information when <tt>-fomit-frame-pointer</tt> is used
with stdcalls. This may lead to crashes when exceptions are thrown.
The workaround is to always use two flags:

<tt>-fomit-frame-pointer -maccumulate-outgoing-args</tt>.

Note for MIPS CPUs without FPU: It's recommended to compile
all sources with <tt>-msoft-float</tt>, even if you don't use
any floating point ops anywhere. Otherwise context switching must
save and restore FPU registers (which needs to go through
the slow kernel emulation).

To run Coco with » Valgrind
(a memory debugger) you must add <tt>-DUSE_VALGRIND</tt>
to <tt>MYCFLAGS</tt> and recompile. You will get random errors
if you don't! Valgrind 3.x or later is required. Earlier versions
do not work well with newly allocated C stacks.

Copyright © 2005-2008 Mike Pall

·
Contact

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Seattle punks Dead Bars have announced details of their second album 'Regulars' (out 3 May) and shared a Bandcamp stream of lead single 'I'm a Regular'. Produced by Jack Endino and released via Anti-Flag's A-F label, the song captures what vocalist John Maiello describes as the 'moments of highs and lows; loneliness and community, sadness and celebration' that come with being in a band.
John offers self-depreciating thoughts as he asks what it means to be a 'regular' person over garage rock hooks and punky riffs that sit neatly beside The Get Up Kids and Pkew Pkew Pkew. You can't help but feel his pain as he reveals 'I'm a regular but nobody says 'here he comes" and follows this up with the sad statement 'I guess I'm not special enough'. He then reveals how being set in your ways can have a negative effect when it comes to getting out there and making a difference: 'I might do something different tomorrow but I probably won't'.
'Regulars' is released on 3 May via A-F Records in the North America, Eager Beaver Records in Japan, No Reason Records in Italy, and All In Vinyl in the UK.


The lead singer of the popular Christian band, Casting Crowns, is speaking out about his cancer diagnosis and the important lesson he learned about God during the ordeal.
"It was definitely out of nowhere," Mark Hall told "The Church Boys" podcast. "I went to the doctor to be checked for acid reflux. He was just doing a scan to see if I had ulcers or anything else going on down there, and then, on accident, saw a tumor in my kidney."
Hall said it was Divine intervention that the doctor discovered the tumor. It was still fully encased, meaning it had not spread to the kidney surrounding it.
Still, according toDeseret News , the cancer was a nuclear level 3 cell type, and the potential was high that it would grow aggressively.
"For a day there it really rocked me," he said. "I was going through feelings and doubts and fear and worry... my feelings were all over the map."
The diagnosis presented a test for the successful singer and youth pastor.
suddenly, I'm in the middle of my own," he said. "It was definitely a shock."
However, his faith in Jesus Christ sustained him.
"My feelings kept slamming up against something solid in me, and that was the roots of my faith," Hall said.
Hall said one central theme surfaced in his heart and mind: "God is who he said he is." Realizing that enabled him to concentrate on his faith during the times of uncertainty.
"The night I found out I sat down at the piano and wrote a song called, 'Oh My Soul' around that Scripture, because that's kind of where I was living at the moment," he said.
Eventually, doctors were able to remove his kidney, and the cancer did not spread. A grateful Hall and his family call it a miracle.
The singer/pastor hopes his story and music will encourage people to remember the message that he held onto during the storm, "that God is who he says he is - and we can trust him."


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Merkel's crisis-hit CDU sets April 25 to pick new leader
BERLIN: Germany's Christian Democrats (CDU) said on Monday they would hold a congress on April 25 to pick a new leader who they want to succeed Chancellor Angela Merkel, scrambling to resolve a crisis shaking the party's hold on power.
The decision on the succession timetable came after voters saddled the CDU with its worst result in a state vote in Hamburg on Sunday, punishing it for flirting with the far right in an eastern state and hastening a messy leadership battle.
The CDU succession debate was blown wide open earlier this month when party leader Annegret Kramp-Karrenbauer unexpectedly said she would no longer seek to succeed her mentor Merkel.
"A new party chairman or chairwoman will be elected at this party congress," Kramp-Karrenbauer said of the April 25 meeting. "This is a clear signal for the CDU candidate for chancellor''.
Merkel, chancellor for almost 15 years, has said she will not run again in the next federal election, due by October 2021.
Kramp-Karrenbauer, tasked by the party with organising the succession, said she had agreed the timetable and procedure with the four leadership contenders to have come forward so far.
The four are Armin Laschet, premier of North-Rhine Westphalia, Germany's most populous state; Friedrich Merz, who narrowly lost a 2018 battle for the chair to Kramp-Karrenbauer; Health Minister Jens Spahn and Norbert Roettgen, head of parliament's foreign affairs committee.
Many analysts believe a cohabitation arrangement of party chair and chancellor would be more difficult if Merz, an erstwhile rival of Merkel, captures the CDU leadership.
The centre-left Social Democrats — junior partners in Merkel's ruling coalition — have signalled they could quit the government if she is forced out as chancellor.
Kramp-Karrenbauer stressed the party's top brass expected the winner of the leadership contest to work alongside Merkel.
"Everyone assumes that there will be good cooperation with both the Bundestag parliamentary group and the CDU-led federal government —and this is certainly a question and a requirement that all candidates will have to meet," she told reporters.
Kramp-Karrenbauer's decision to give up her ambition of succeeding Merkel came after an eastern branch of the CDU defied the national party and voted with the far-right Alternative for Germany (AfD) to install a state premier from a third party.
That broke a post-World War Two consensus among established parties in Germany that the far right should be shunned.
In Hamburg, the CDU slipped into third place, scoring just 11.2 per cent in the northern port city — behind the SPD, for whom the city is a stronghold, and the Greens.
Mass-selling daily Bild dubbed the Hamburg result a "debacle" for the CDU, whose faltering leadership has raised questions over the future course of Europe's largest economy.
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Mass strike enters fifth day in Matamoros, Mexico
Thousands gather at mass meeting as maquiladora strike grows
By our reporters
As new manufacturing plants join the growing strike in Matamoros, Mexico, over 70,000 workers are confronting threats of mass firings and plant closures by the employers and advancing their fight against social inequality.
Mass Assembly at the Matamoros plaza (Credit Esteban Martínez)
Amid a media blackout by Mexican and international outlets, the ruling class has demonstrated a profound fear that the rebellion by Matamoros sweatshop workers who produce auto parts and other goods supplying the main auto companies in North America, Europe and Asia will inspire workers to take up the same fight in the rest of the industrial belt along the US-Mexico border and spill over across the North American continent and beyond.
Over the weekend, workers affiliated to the Union of Laborers and Industrial Workers of the Maquiladora Industry (SJOIIM) decided in mass assemblies and discussions on social media to walk out in defiance of the trade union and the Matamoros government controlled by the ruling National Regeneration Movement (Morena) of President Andrés Manuel López Obrador (AMLO).
The answer is 'No.' No one should work tomorrow. The fight for a better future has begun.
The state and city governments and trade-union officials have taken over the bargaining for the companies, ordering the strike to end and defending the maneuvers by the companies to infringe the contracts and continue extracting massive profits from the super-exploitation of the Maquiladora workers, who make on average $9 a day.
At least five workers confirmed to the WSWS Autoworker Newsletter that the SJOIIM officials were intimidating workers with a shadowy statement by the Secretary of Labor of the state of Tamaulipas declaring the strikes illegal. Moreover, live feeds were shared online of workers denouncing officials of SITPME (known as the Mendoza union) for threatening layoffs and violence if workers joined the strike.
In response, increasing numbers of workers from both unions and other smaller ones have joined the strike, with many demanding that the trade unions "get out."
A statement voted by striking workers at the Tridonex plant on Wednesday reads, "Today, we have a unique chance that we will never have again. All workers disagree with the injustice sustained by the trade union and with the dues they take from us weekly. Today we can fight for a change, all of us together. Let's have no fear and not let them intimidate us."
Earlier this year, the AMLO administration and the employer organizations agreed to implement a 100 percent increase of the minimum wage at industrial cities along the US-Mexico border largely to feed illusions in the new government and ease class tensions. The negotiators felt at the time that trade unions and threats would suffice to force cuts to bonuses and other benefits in exchange for the raise.
When the strike began on Saturday, workers were initially demanding the 100 percent raise. In order to take up the demands and prevent the protests from escaping its control, the SJOIIM agreed to request companies a 20 percent raise and a bonus of 32,000 pesos (US$1,700).
Workers had organized a general assembly on social media for Wednesday afternoon to get rid of the union leadership and discuss how to continue the struggle once the deadline for paying the bonus expired according to the labor contract.
The companies have responded with escalating intimidation, making clear that they will not even consider the workers' demands. On Tuesday, the main business chamber in Mexico COPARMEX (Employers' Confederation of the Mexican Republic) threatened that if the strike continues, "maquiladoras will look for other options with cheaper labor."
On Tuesday night and Wednesday morning, dozens of workers at the Cepillos plant in Matamoros, some of whom had worked there for more than 20 years, were summarily fired for not agreeing to sign a 6 percent wage increase.
The SJOIIM then carried out a stunt before this assembly, filing a legal "strike announcement" requiring workers to wait 6 to 10 days before a strike can "officially" begin. To a question after a reporter whether a strike would actually begin, the widely loathed union leader Juan Villafuerte responded, "I don't know."
Delegations of rank-and-file workers sent for this announcement then returned to their plants to inform the other strikers about the union's decision.
"The union made the rounds for a work stoppage, but we don't trust the union because Mr. Juan Villafuerte is corrupt and, in fact, we'll ask for his resignation because we don't want him anymore. We'll either put someone else or eliminate the union forever," an Autoliv worker named Mika told the WSWS.
With similar sentiments, workers soon began to march from the picket lines in the thousands to the central plaza in Matamoros ahead of their planned afternoon assembly. For most, the walk took more than one hour, and, in some cases, workers decided to leave, some to guard the plants to prevent closures by management.
Later in the afternoon, workers at the plaza began reporting threats of mass layoffs and that trucks had arrived at some plants to take the equipment away. Nevertheless, the thousands of workers who gathered at the assembly pledged to continue fighting and expand their strike. One popular slogan of the strike is, "they can fire 10 or 20 of us but they can't fire all of us." Striking workers in Matamoros are setting a powerful example for workers across the border in the United States and beyond. Many have expressed their support for the Mexican workers' struggle through the WSWS Autoworker Newsletter.
The ATD company threatened striking workers with being 'penalized and its implications'
Workers in the US and Mexico should come together to fight for "job security and good pay," said Steve, a Fiat-Chrysler worker in Belvidere, Illinois. "Those people receive slave pay and deserve better. The reason most Mexicans try to cross the border is for a better-paying job and benefits for their families."
Similarly, Matamoros workers in contact with the WSWS have all expressed support for joining their struggle with their working-class brothers and sisters across North America. Expressing disgust over the announcement of mass layoffs and concessions against workers by GM in the US and Canada, Mika, the Autoliv worker, stated: "I only have one thing left to tell those workers: do not to let the company do it. Fight until the end because we all deserve a decent living."
July, a striking worker at the Easy Way plant in Matamoros, called on workers across North America to "unite and fight for what is right, nothing more than having a better future for our families. Together we can defeat all of those exploiters that have enriched themselves thanks to that enslavement that we live. In our case, we work more than 10 hours each day and Saturdays for a low salary that is not enough."
Whether it is in Mexico, the US, Canada or around the world, the decades of continued abuses and austerity overseen by bankrupt nationalist politicians and their union allies have demonstrated that workers can only defend their social and democratic rights by organizing independently of the trade unions and fighting to build an international political movement of the working class to expropriate the means of production of wealth controlled by the capitalist class and establish the United Socialist States of the Americas.
On February 9, at 2 p.m. autoworkers will demonstrate at GM world headquarters in Detroit, Michigan to oppose the job cuts and concessions announced by the auto and parts companies. Workers from across the world can follow and support this demonstration on Facebook here.
The Matamoros workers rebellion
GM workers in Mexico thank US workers for donating to their defense fund
AFL-CIO, Mexican government seek to chain renewed struggles across Matamoros to "independent" trade unions
New pamphlet on Matamoros wildcat strikes
Matamoros workers run for office: The political questions
Police and military crack down on spontaneous taxi strike in Matamoros, Mexico
Saskatchewan NDP silent on oil refinery lockout
Detroit, Michigan man declared innocent and released after nearly 30 years of wrongful imprisonment


Botox continues to be the number one cosmetic procedure performed worldwide. Physicians from a wide range of specialties – not just dermatologists but also OBGYNs, primary care practitioners and ophthalmologists – are eager to learn from results-focused educational material written by leading practitioners.
Most botox books focus solely on injection technique. Handbook of Botulinum Toxins for Aesthetic Indications: Theory and Practice describes current techniques, but focuses on securing optimum results in different patient types, e.g. patients of different ethnicities, patients with thick skin, heavy brows, and so on. In addition, the book covers hot topics such as the use of new types of neurotoxins, the problem of counterfeit products, and combining neurotoxins with other modalities such as fillers and lasers.
Edited by a recognized educator in this area, and taking a unique problem-based approach, Handbook of Botulinum Toxins for Aesthetic Indications gives practical guidance on the use of different strategies in different patient types to ensure the best possible aesthetic results.
Botulinum toxin (BTX) is a neurotoxic protein produced by the bacterium Clostridium botulinum and related species.
The goal of this book is to introduce a new generation to this fascinating drug as well as to expand the clinical knowledge of those who are already familiar with them. This book is divided into 11 chapters.
First chapter discusses on structure and function of different neurotoxin types.
Safety and liability issues of BTXs are covered in second chapter.
The aim of third chapter is to introduce different types of injection techniques for forehead and eyebrow shaping.
Fourth chapter focuses on the use of neuromodulators in the periorbital region.
Fifth chapter focuses on the treatment of the mid and lower face and provides recommendations based upon guidelines from peer-reviewed journals and consensus groups.
Sixth chapter aims to describe the role of botulinum toxin A (BTX-A) in the jawline, neck, and décolletage, including the importance of combination therapy with adjunctive surgical and nonsurgical rejuvenation techniques, and the critical challenge of appropriate patient selection.
Treatment of hyperhidrosis (HH) of the axilla, hands, feet and other body areas with the help of injection techniques are described in seventh chapter.
Eighth chapter aims to describe the concept and technique for reshaping of the lower face.
Ninth chapter focuses on the combined application of neurotoxin and multiple laser sources.
Combinations of neurotoxins with fillers has been described in the tenth chapter.
The last chapter of this book discusses on topical BTX.


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2034-BW-19 CONVICTION HIGHBURY CORNER MAGISTRATES COURT
Faisal Mirzia sold fake goods from a stall in Camden Market
Faisal MIRZIA (born 07 10 2000) of Victoria Road, Edmonton, N18 2UF appeared at Highbury Corner Magistrates Court on the 11th April 2019, charged with four offences of selling counterfeit goods and possessing counterfeit goods for sale contrary to Section 92 of The Trademarks Act 1994. He pleaded guilty to all matters. He was sentenced to a fine of £100 and ordered to pay £50 towards prosecution costs and a £30 victims surcharge.
Mirzia ran a stall in Camden Green Market, Camden High Road, Camden, London, NW1 selling a wide variety of fake goods from various luxury goods brands including Michael Kors, Chanel, Miu Miu, Kenzo, Gucci, D&G and many others. No enforcement action action was taken in relation to these brands.
Camden Market and is open every day throughout the year. This is a popular area for tourists where the widespread sale of counterfeit goods is common place.
Between the 24th January 2019 and 12th February 2019, three test purchases were conducted from Faisel MIRZIA by detectives from TM Eye's Dedicated Undercover Unit.
All of the purchases were covertly recorded and MIRZIA could be clearly identified from the relevant footage. This evidence led to the prosecution and conviction.
TM Eye Director David McKelvey said,"This is the latest conviction by TM Eye detectives of a criminal operating in the Camden High Road area. TM Eye has convicted over 60 persons in recent years in that specific area of Camden for similar offences. There has been a significant reduction in the open sale of fake goods of brands TM Eye represents with criminals deliberately avoiding them through fear of prosecution.
TM Eye will continue to target those who commit such criminality and will bring them to justice. Mirzia now has a criminal conviction and his fingerprints, photograph and DNA will be taken. The UK Border Agency have been informed in order to consider his immigration status.


Entrance Hall Stairs to first floor. Doors to sitting room, dining room and kitchen. Gas central heating radiator. Exposed beams.
Sitting Room 6.40m x 4.55m (20'11" x 14'11") A spacious sitting room with windows to both the front and rear offering a double aspect. Door opening out to the garden. Log burning stove inset to exposed brick chimney breast. Gas central heating radiator. Exposed beams.
Dining Room 5.33m x 3.76m (17'6" x 12'4") Original fireplace to chimney breast. Gas central heating radiator. Window. Door out to garden. Door to study.
Study 3.86m x 3.76m (12'8" x 12'4") Window overlooking the garden. Log burner inset to chimney breast with exposed brick surround. Gas central heating radiator.
Kitchen 4.83m x 3.73m (15'10 x 12'3") Fitted with a range of wall, base and drawer units with work surfaces over. Stainless steel sink and drainer with mixer tap. Integrated eye level double electric oven and four ring hob with extractor hood over. Plumbing for dishwasher. Two windows and skylight windows. Tiled flooring. Exposed beams.
Inner hall Door to WC. Stable entrance door.
Coakroom/WC Fitted with a two piece white suite comprising WC and wash hand basin. Part tiled walls. Window.
Utility 4.90m x 3.56m (16'1" x 11'8") A spacious utility room, fitted with a range of wall and base units with work surfaces over. Stainless steel sink and drainer with mixer tap. Plumbing for washing machine and space for tumble dryer. Tiled flooring. Entrance door.
Playroom 6.53m x 4.88m (21'5" x 16'0") Skylight window. Part tiled and carpeted flooring. Gas central heating radiator.
Sun Room 9.12m x 3.28m (29'11" x 10'9") A bright and airy room with a double aspect view of the garden. Log burner. Three sets of double doors open out to the garden. Feature high ceilings with skylight window and exposed beams. Oak flooring.
Landing Two windows. Linen cupboard. Two separate stairs in turn lead to the second floor.
Bedroom 3.84m x 3.68m (12'7" x 12'1") Window overlooking the garden. Gas central heating radiator.
Bedroom 4.93m x 3.68m (16'2" x 12'1") Window overlooking the garden. Gas central heating radiator. Fitted wardrobes providing hanging and shelving storage.
Bedroom 3.89m x 3.48m (12'9" x 11'5") Window overlooking the garden. Feature fireplace. Fitted wardrobe providing hanging and shelving storage.
House bathroom Fitted with a three piece white suite comprising bath with hair wash attachment to the taps, WC and wash hand basin with mixer taps set in vanity storage unit. Further storage cupboards. Tiled walls. Window. Exposed beam. Inset ceiling spotlights. Heated towel rail.
Shower Room Fitted with a three piece white suite comprising shower cubicle, WC and wash hand basin set in vanity storage unit.
Bedroom 4.70m x 3.81m (15'5" x 12'6") A spacious double bedroom with double glazed window overlooking the garden. Gas central heating radiator.
Separate WC Fitted with a two piece white suite comprising WC and wash hand basin with mixer tap. Tiled walls.
Master Bedroom 4.01m x 3.76m (13'2" x 12'4") A delightful master suite with window overlooking the garden. Exposed beams. Gas central heating radiator. Walk in wardrobe. Door to ensuite.
Ensuite Shower Room Fitted with a three piece white suite comprising walk in double shower, WC and wash hand basin. Exposed beams. Window.
The Cottage Detached from the main house, this is the former cart shed which has been converted in to a self-contained single storey cottage/bungalow. The cottage has been fully refurbished and is finished to a modern standard that is ready to move in to. The cottage comprises a modern fitted kitchen, sitting room, two double bedrooms and a shower room. Doors open out from both the kitchen and the master bedroom and the property is suitable for wheelchair access. The cottage is rated separately for council tax and has a separately metered gas and electricity supply so could be rented out easily.
Lounge 4.60m x 2.90m (15'1" x 9'6") Double glazed window to the front. Gas central heating radiator. Open to hallway.
Kitchen 2.79m x 2.59m (9'2" x 8'6") A modern kitchen, fitted with a range of wall, base and drawer units with work surfaces over. Stainless steel sink and drainer with mixer tap. Integrated electric oven and hob with extractor hood over. Plumbing for automatic washing machine. Entrance door and window to the front.
Bedroom One 4.90m x 3.20m (16'1" x 10'6") Window and door to front opening out to the garden. Gas central heating radiator.
Bedroom Two 3.51m x 2.79m (11'6" x 9'2") Window to the front. Feature high ceiling with exposed beams. Gas central heating radiator.
Shower Room A contemporary shower room, fitted with a three piece white suite comprising walk in shower, WC and wash hand basin set in vanity storage unit. Tiled walls. Heated towel rail. Skylight window.
Viewing Arrangements Strictly by appointment. Please contact the agent to arrange a viewing.


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Largest UK Offshore Wind Farm Under Construction
Work has just started on what is billed as the largest wind farm in the UK. The wind farm will be able to power up to 4.5 million homes when it becomes operable.
Construction has started for the offshore wind farm in the North Sea. According to an announcement by energy supplier SSE, the onshore work for the 3.6 gigawatt (GW) Dogger Bank Wind Farms project has started near Ulrome, which is a coastal town in the East Riding of Yorkshire, England.
The wind farm will consist of three 1.2 GW offshore sites: Creyke Beck A, Creyke Beck B (located about 130 km from the Yorkshire coast) and Teesside A (located about 200 km offshore). The joint venture project is between SSE Renewables and Equinor, a Norwegian energy supplier.
The project will use GE's Haliade-X wind turbine, which has a 12 megawatt generator and stands 260 meters tall. When completed, the project will have enough capacity to produce renewable energy for more than 4.5 million homes per year, according to SSE.
Construction and installation of the onshore cable infrastructure has been awarded to Jones Bros Civil Engineering. The work will also involve building earthworks for the onshore HVDC converter station locations in East Riding.
The onshore infrastructure will include about 20 miles of electrical cables within ducts. The ducts, will be installed in trenches, and where necessary will involve drilling under existing infrastructure and natural obstacles. When completed, the onshore cable will transport generated power from the two offshore wind farm sites, Creyke Beck A and Creyke Beck B, from the landfall point near Ulrome, and then to the convertor stations in the south of Beverley.
The works contract also allows for the clearance of vegetation, the preparation of access junctions and the construction of a temporary access road to make it easier to access the main works. This part of the project will take about 2 years to complete.
Garod Evans, Jones Bros Contracts Director, said, "We have worked with SSE Renewables on major schemes previously and we are delighted to be developing our partnership through working with them and now Equinor on the onshore works for Dogger Bank Wind Farms. There will be up to 100 Jones Bros personnel, from management to apprentices and trainees, on site at the height of the works."
Steve Wilson, managing director of Dogger Bank Wind Farms, said, "Getting the first spade in the ground is a significant milestone on any project, but for what will be the world's largest offshore wind farm, this is a major moment for a project that has already been over a decade in the making."
The UK, one of the major players in the offshore wind sector, also includes other large projects, such as the Walney Extension 659 megawatt facility in the Irish Sea. This wind farm was opened in 2018.
The Walney Extension wind farm powers more than 590,000 homes with its 87 turbines, and covers an area equal to 20,000 soccer pitches, according Orsted, a Danish energy company.
Europe is a major player in offshore wind farms. According to WindEurope, an industry body, 409 wind turbines were connected to the grid in 2018. Back in 2018, the average size of offshore turbines was 6.8 MW, which was a 15 percent increase compared to 2017.
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NYPD Red: A maniac killer targets Hollywood's biggest stars
James Patterson (Autor)
Every cop wants to be part of NYPD Red.
It is the elite team in New York's police department, handling the cases involving the most important and high-profile individuals in the city. It's Detective Zach Jordan's dream job, but he's about to step into a nightmare.
In the middle of a New York film festival, a maniac begins a very public and very brutal killing spree targeting Hollywood's biggest stars.
Zach is assigned a new partner, Detective Kylie MacDonald, who is also his ex-girlfriend. But they'll need to put their history aside to have a chance of stopping this homicidal psychopath before he brings New York City to its knees.


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Medtronic to expand Ireland offices: 3 notes
Medtronic received permission from the Industrial Development Authority of Ireland to expand its Galway-based offices, according to Galway Daily.
Here are three things to know:
1. The expansion will include a two-story addition to its second campus building as well as construction of a new entrance lobby, complete with a bridge linking to the new extension on the first floor.
2. The two-story addition will be built on the campus' current parking lot, resulting in construction of a new lot designed to accommodate 92 car and eight motorcycle spaces.
3. Medtronic is headquartered in Dublin, but its operational headquarters are in Minneapolis.


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Home Guide to Restarting Events Las Vegas Ramps Up For Large-Scale Meetings
Guide to Restarting Events
Las Vegas Ramps Up For Large-Scale Meetings
Las Vegas Convention Center West Hall expansion set to host World of Concrete.
Las Vegas is set to host World of Concrete Jun. 8-10, which will be the first large-scale, in-person trade show to return to the U.S. market since the pandemic.
The commercial construction industry trade show will also be the first large-scale event to take place at the Las Vegas Convention Center's new West Hall Expansion, which has added 1.4 million sf to the facility, including 600,000 sf of new exhibit space.
The trade show was rescheduled last September from January to June due to concerns related to the pandemic, but was contingent on the city's reopening. Following the announcement by Nevada Governor Steve Sisolak in April, which set a goal for a full reopening to 100% capacity by Jun. 1, 2021, the event organizer Informa Markets worked with the Las Vegas Convention Center to submit a health and safety plan to the Nevada Department of Business and Industry.
The health and safety plan is based on Informa Markets' Informa AllSecure framework, a set of safety protocols to prioritize guest safety at trade events, including enhanced cleaning, personal hygiene stations, temperature checks, increased air filtration, physical distancing and more. Face masks are recommended but not required at the event, and will be available onsite if attendees do not have their own.
Conventions such as World of Concrete are critical to the Las Vegas economy, and during a normal year add more than $11 billion in economic impact, according to the Las Vegas Convention and Visitors Authority.
Las Vegas Monorail Reopens
Ahead of the event, the Las Vegas Monorail resumed its operations on Thursday, May. 27, 2021, in time for Memorial Day weekend and upon completion of all systems safety inspections.
The 3.9-mile elevated system along the Las Vegas Strip enables passengers to travel the length of the resort corridor in less than 15 minutes, at speeds of up to 50 miles per hour. Trains arrive every 4-8 minutes at each of the seven stations along the Las Vegas Strip.
"The Las Vegas Monorail has provided an important and convenient transportation solution for both leisure visitors and convention attendees," said Steve Hill, president and CEO, LVCVA, in a press release statement. "We are thrilled to resume normal operations in time for both Memorial Day weekend and World of Concrete, allowing us to provide a reliable and safe transportation solution for passengers looking for an efficient way to navigate to the Las Vegas Convention Center and throughout the resort corridor."
The same health and safety requirements that exist throughout the destination will also apply on the Monorail, including face masks required at all times throughout the system, hand sanitizer available at every Monorail station, and recommended social distancing whenever possible.
The LVCVA acquired the Monorail in December 2020 to ensure the transportation option was preserved and to allow for additional transportation options on the east side of Las Vegas Blvd. The system is 100 percent electric and runs zero emission trains, therefore reducing both emissions by more than 27 tons and more than 2 million vehicle miles annually in Southern Nevada.
Coming Soon to Las Vegas
Following on the heels of World of Concrete, Las Vegas has a busy calendar of events ahead, including Meeting Professionals International's (MPI) WEC Vegas event taking place Jun. 15-17, 2021 at CAESARS FORUM. Other large-scale meetings include The International Surface Event, set to take place Jun. 16-18, 2021, at Mandalay Bay Convention Center; International Esthetics, Cosmetics & Spa Conference taking place Jun. 20-21, 2021, at the Las Vegas Convention Center; and Waste Expo 2021, taking place Jun. 28-30, 2021, also at the Las Vegas Convention Center.
The Las Vegas events calendar is packed through summer and fall, and includes the return of IMEX America 2021, taking place Nov. 9-11, 2021, at the Mandalay Bay Convention Center. The event will feature more than 3,500 exhibitors from 155 countries, and will operate under health and safety protocols including mandatory badging and face masks, exhibit hall density, electrostatic spray treatment each night in accordance with BCAC standards, hand sanitizer stations, as well as Perspex sneeze guards at counters where interaction is likely, such as food service areas, check-in counters and information booths. The Mandalay Bay resort is also equipped with a highly efficient ventilation system that provides 12 full air exchanges per hour and meets the current GBAC standards.
The full Las Vegas convention calendar for 2021 is available here.
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The Inglewood Oil Field is seen on March 9, 2020, in Los Angeles. (Lionel Hahn/Abaca/Sipa USA via AP Images/CNN)
U.S. oil prices crash below $0 a barrel — a record low
Posted: Apr 20, 2020 / 08:32 AM PDT
Updated: Apr 20, 2020 / 03:49 PM PDT
The spectacular collapse in oil markets is showing no signs of easing, as the coronavirus crisis saps demand and producers run out of places to store all their excess barrels of crude.
What's happening: US oil prices plunged, falling below $0 Monday to $-37.63 a barrel. That's the lowest level since NYMEX opened oil futures trading in 1983.
The selloff can be attributed in part to market mechanics. The May futures contract for West Texas Intermediate, the US benchmark, is about to expire. Most investors are already focusing on the June contract, thinning out trading volume and feeding volatility, UBS analyst Giovanni Staunovo said.
The June futures contract for WTI is trading around $22 per barrel, but that's still sharply lower on the day. Brent crude futures, the global benchmark, fell 8% Monday to $25.81 per barrel.
The extreme pressure on the WTI contract for May highlights ongoing concerns about the supply and demand dynamics plaguing the oil market.
"No one in America wants oil in the short term," Jeffrey Halley of Oanda told clients on Monday.
Saudi Arabia, Russia and other producers tried to prop up prices with a deal last week to slash production by 9.7 million barrels per day in May and June, the deepest cut ever negotiated. But that isn't expected to soak up the supply glut caused by evaporating demand for energy.
Oil storage facilities are still at risk of overflowing, raising the chance that some oil producers in the United States and Canada could start paying customers to take crude off their hands, according to Staunovo.
Investors are particularly worried about storage reaching capacity in Cushing, Oklahoma, the main US hub.
Rystad Energy, a consultancy, forecasts that US commercial crude stocks will hit all-time highs by the end of April and will continue rising into May.
The most disappointing earnings season since 1998?
Following the major American banks, Coca-Cola, Netflix, Delta, IBM and Intel are among the big US companies scheduled to report earnings this week.
OPEC, oil nations agree to nearly 10M barrel cut …
Trump gives governors a 3-phase plan for reopening …
China attempts to revive economy but consumers are …
First up is IBM, which is on deck Monday after US markets close.
Fewer than 10% of S&P 500 companies have reported results for the January to March period to date. So far, they've "generally disappointed relative to tepid expectations," according to David Kostin, chief US equity strategist at Goldman Sachs. The investment bank calculates that 43% of companies have missed Wall Street's predictions, on pace for the highest rate since at least 1998.
FactSet analyst John Butters predicts that S&P 500 earnings dropped 14.5% in the first quarter. That would mark the largest year-over-year decline for the index since the third quarter of 2009.
Watch this space: Much of the attention will be on expectations for full-year earnings, as investors try to assess how the coronavirus pandemic will hit businesses over a longer period. But Kostin notes that most strategists have written off 2020 entirely and are already looking ahead to 2021.
US stocks have risen three of the past four weeks
US futures are off on Monday as global stocks struggle to find direction and oil crashes. But taking a step back, the stock market appears to be in recovery mode.
See here: The S&P 500 has jumped three of the past four weeks after nosediving into the fastest bear market in history.
The broader picture, of course, is complicated. "The confusing thing for markets at the moment is the huge dichotomy between what will possibly be one of the worst synchronized global economic slumps in history against what is undoubtedly the largest ever intervention," Deutsche Bank strategist Jim Reid told clients Monday.
Deutsche Bank noted last week that top central banks have expanded their balance sheets by $2.7 trillion, two thirds of which has come from the US Federal Reserve. But negative economic data could continue to cause problems for investors who are ready to get back into riskier assets, with uncertainty about how long lockdowns will last remaining a key issue.
Ally Financial, M&T Bank and Truist report earnings before US markets open. IBM follows after the close.
Also today: The United Kingdom and the European Union restart talks over their future relationship following Brexit.
Coming tomorrow: Coca-Cola and Netflix report earnings.
Trademark and Copyright 2023 Cable News Network, Inc., a Time Warner Company. All rights reserved.


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TwistedWave, an audio editor for mac.
Easy to use, fast, powerful.
Mastering. Equalization, compression, limiting, you name it... From the hundreds of available Audio Unit or VST plugins, you will surely find the right one for the best effect.
Converting files. TwistedWave can read and write files in many different formats. Converting a single file, or a whole folder of audio files from one format to another is straightforward.
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With a powerful built-in silence detector, TwistedWave makes it very easy to automatically split an audio file into several parts separated by silences, and save them in distinct files.
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When TwistedWave is busy loading a large file, or applying a complex effect, all the work happens in the background, and you can continue working with your document, applying new effects to the wave. With TwistedWave, the time where you had to wait for your audio editor to perform a long computation is over. Read more.
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Chemistry & Industry
Current: Bridging the gap
C&I Issue 8, 2013
Existing pharmaceuticals can only tackle 10–20% of known drug targets, leaving at least 80% 'undruggable'. Many of these undruggable targets involve proteins inside cells, but our inability to reach them may be about to change. In May 2013, Aileron Therapeutics announced the successful completion of Phase 1 clinical trials of its first so-called 'stapled peptide' drug – the first in a potentially game-changing new class.
Currently, there are a limited number of peptide drugs on the market, such as the diabetes drug Byetta. These drugs target receptors on cell surfaces. However, by forming a hydrocarbon bridge between amino acids in a peptide chain, researchers can create drugs that reach previously inaccessible disease targets within cells.
The bridge, or 'staple', forces the peptide to adopt the α-helical shape found in proteins. It is this structural change that gives stapled peptides their drug-like properties. As well as penetrating cells, stapled peptides stay active in the body longer than other peptide drugs.
Their helical conformation protects them, because peptide-digesting enzymes within the body only recognise and breakdown unravelled peptide chains.
The field of stapled peptides was pioneered in the late 1990s by Gregory Verdine, the late Stanley Korsmeyer and Loren Walensky, at Harvard University, US, and the associated Dana-Faber Cancer Institute. In 2004, the team published a ground-breaking paper that showed a stapled peptide could block the growth of leukaemia cells in mice (Science, 2004, 305, 1466).
Chemical biologist, Verdine explained: 'We wanted to maximise the likelihood of cell penetration, and so unlike what everyone else had done previously, we put only hydrocarbon atoms in the macrocyclic bridge.' The hydrocarbon staple is made by incorporating two amino acids with attached alkene groups into the peptide chain. The alkene groups are then connected using the 2005 Nobel-prize winning ruthenium-based Grubbs catalyst. The staples are generally applied across one or two helical turns.
The resulting stapled peptides combine the desirable features of the two main existing drug classes: their ability to lock-in to target proteins gives them the specificity of biological molecules such as antibodies; and their small size (around 50 amino acids) allows them to penetrate cells like small molecule drugs.
The potential for this new type of drug is large in Verdine's opinion. 'The operating theatre of small molecules is about 10% of human targets,' he says. 'If we take biologicals… that's 10%...if stapled peptides can reach another 10%, they would have the impact of the entire pharma or biologics industry.'
Aileron Therapeutics was founded in 2005 by a team including Verdine and Walensky. The start-up's financial backers include the venture arms of four big pharmaceutical companies – an indication of how seriously stapled peptides are being taken. In 2010, Aileron established a collaboration with Swiss pharmaceutical giant Roche, potentially worth $1.1bn. It includes drug development targets in five areas: cancer, viruses, inflammation, metabolism and the central nervous system.
Stapled peptide design almost always starts with the synthesis of an α-helix sequence from a natural protein, but to be an effective drug, the peptide needs to be cell-penetrating. Stapled peptides are thought to enter cells like viruses, via active take-up.
Aileron is confident it can develop stapled peptides that enter cells. Vice president of corporate development, Huw Nash comments: 'We have a very good understanding of the structure–activity relationship guiding stapled peptides entry into a cell or what keeps it outside the cell…we've learnt the rules that help optimise that process.'
Verdine describes optimisation to find the best drug molecule as 'the heavy lifting part'. 'You need to screen a panel of peptides in which you move the staple around to different positions and in some cases we've shown you have to tweak certain residues in order to maximise cell penetration, sometimes you need to redistribute residues on the peptide, sometimes you need to replace negatively charged residues with uncharged versions.'
Aileron's first stapled peptide through Phase 1 clinical trials, ALRN-5281, boosts human growth hormone in patients with rare endocrine disorders. Vice president of clinical development, Hubert Chen explains: 'Endocrinology and metabolic disorders are definitely going to be opened up by the stapled peptides approach, because of our ability to rationally design long-acting hormones'.
In this case, the drug's target is on the cell surface. But the use of stapled peptides offers advantages over present therapies. Existing drugs provide artificial hormone replacements at dosages that lead to abnormally high hormone levels in patients, causing side effects such as swelling, joint pain and diabetes. The stapled peptide drug works by stimulating the body's own growth hormone production. It is therefore better able to replicate normal physiological hormone levels and should reduce side effects
A growing number of studies show that stapled peptides can reach previously undruggable cancer targets. The peptides are able to turn on or off the processes that activate cell death or promote cell survival by disrupting how genes control protein synthesis.
In 2012, Aileron and Roche announced promising preclinical results on a stapled peptide cancer drug (ATSP-7041). The drug works by reactivating a cell death pathway known as p53. This pathway plays a critical role in protecting cells. '50% of all human cancers retain wild-type p53 and would be potential candidates for this mode of action – that's an extraordinarily large number', says Nash.
Stapled peptides drugs could also provide solutions to chemotherapy resistance, where previously successful cancer treatments suddenly stop working. Aileron is creating stapled peptides that tackle the B-Cell lymphoma 2 (Bcl-2) family of proteins, which are involved in cell death. Over-expression can lead to chemotherapy resistance, but stapled peptides are able to block their activity and activate cancer cell suicide pathways.
Another area studied is HIV infection. David Cowburn, at the Albert Einstein College of Medicine in New York and Asim Debnath at the New York Blood Center in the US, showed, in 2008, that a stapled peptide disrupts the viral outer shell or 'capsid', which will prevent replication. Cowburn concedes that the work is still at an early stage. 'The affinity is still too low to use stapled peptide in their current published integration as a drug. The success of this scientifically is validating the mechanism fully,' he says.
The development of stapled peptides has not been without drama. In December 2012, a paper from an Australian research team led by Peter Czabotar (ACS Chem Biol., 2013, 8, 2) received attention as it reported that several stapled peptides, originally designed in Walensky's Harvard lab, did not lead to cancer cell death. Walensky responded that the stapled peptides tested were not designed as drugs but for use in NMR studies.
'We weren't surprised by the paper.' Nash says. 'The data were old news. The interpretation beyond that particular compound is not an accurate reflection of the state of the art.'
The controversy is a reminder of how new fields progress. In Verdine's words: 'There's a field that's being birthed here – that's really the news.' In an effort to speed up progress in the field, Verdine, together with Singapore-based collaborator David Lane, are planning to make all their published stapled peptide available to researchers. They want to 'democratise stapled peptides,' which are expensive to make.
But stapled peptides will not reach all drug targets and Verdine's group is starting to work on second generation peptide based therapeutics that he calls 'cell-penetrating mini-proteins'. They are learning how to stabilise mixed α and β structures.
Verdine points to other work in the general field of 'constrained peptides', where peptides are synthesised with cyclic portions to lock in biologically active structures.
In Switzerland, University of Zurich chemist, John Robinson has stabilised β-hairpins. Based on his work, Swiss start-up Polyphor has announced a new class of antibiotics that are effective against drug resistant bacteria.
Given the breadth of drug applications for stapled peptides, has progress been slow? Verdine, who is no longer associated with Aileron, comments: 'Roche and Aileron are being, in my opinion, extraordinarily cautious. You can argue that this is good stewardship of the field, but for those of us who are really eager to see stapled peptides in patients, it's taking a long time'.
Aileron acknowledges it has an embarrassment of riches. 'There are too many good things for Aileron to work on all by ourselves,' Nash comments. 'We are in conversations and will hopefully develop other partnerships.'
Meanwhile, Verdine predicts that the full impact of stapled peptides is some time off. 'I think its going to take a decade for there to be really significant numbers of approved molecules – we are really right at the startling line.'
Rachel Brazil is a freelance science writer based in London, UK
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You will have the rare opportunity to experience life in one of Cambridge's historic Colleges. Enjoy the fellowship of dining in a magnificent hall and sharing relaxed conversation with like-minded students with a wealth of life experience.
Accommodation is in single rooms normally occupied by undergraduates. You can choose a basic room with a bed and washbasin; or one with en suite bath/shower facilities. Breakfast and evening meals are included in the cost. A number of twin en suite rooms are available in Queens' College. Double rooms are not available.
For details of specific accommodation options, please see the 'accommodation tab' on the relevant programme pages.
The accommodation fee pays for a single room, breakfasts and evening meals, unless otherwise stated. Places in all Colleges are allocated on a first-come, first-served basis once you have been accepted to the programme. If requested in advance, couples will be assigned to adjacent single rooms where possible. Twins are for spouses, partners and siblings, only.
All rooms must be vacated after breakfast on your departure date. We reserve the right to charge students for any loss or damage to College property.
If your first option is full, you can add yourself to a waiting list and select a second choice. Colleges will try to meet specific room requests and additional requirements, but this may not always be possible. Please note that room sizes may vary considerably.
Unfortunately we are unable to confirm specific room allocations prior to arrival, nor are the Colleges. We kindly ask you not to contact the Colleges directly.
Unfortunately we are unable to provide College accommodation before or after our programmes. However, if you would like to arrive early or depart after your programme has finished, you may be able to book a room directly with the Colleges once your application has been accepted. Further information will be available on our Virtual Learning Environment (VLE). Alternatively, you can book a room through www.conferencecambridge.com or www.universityrooms.com.
If you are arriving with your luggage, you may prefer to take a taxi from outside the station.


Murray United will face Football Federation Victoria's independent tribunal after being charged with bringing the game into disrepute.
A closed hearing is set down for Wednesday, September 19.
A football operations investigation spanning more than two months was launched into the Border NPL club after allegations Albury-Wodonga Football Association registered player Tyler Curran had lined up for Murray United's under 20s side.
FFV prohibits dual registration under the National Registration Regulations in accordance with FIFA regulations, meaning a player can only be registered with one club at a time.
The AWFA also doesn't permit a player to have dual registration with another club or team in an association outside of AWFA without an approved application.
A photo of Curran was taken during the under-20s clash between Murray United and Werribee City on Saturday, June 16 and appeared on Werribee City FC's Facebook page on Sunday, June 17.
"FFV has referred Murray United to the independent tribunal with a charge of MP10 (bringing the game into disrepute)," an FFV statement said.
"Findings of the independent tribunal will be published on the FFV website after the hearing is concluded and paperwork has been processed.


The Finnish capital is an exciting place to be in and a trip around the city will reveal its unique characteristics to you. The coastal region with its vast archipelago feels ethereal to anyone who loves being in close proximity to nature. Drive your rented car to Central Park and enjoy the many leisure facilities there. Visit Suomenlinna, an impressive sea fortress sitting on an island, by boat. Use the car hire service for enjoying trips to The National Museum of Finland and Ateneum Art Museum located near the city centre. Helsinki is also a place where music festivals and other cultural programs take place year long. Do not hesitate to participate in festivals like Taiteiden Yö if you happen to be in the Finnish capital mid-summer.


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Mental Health Patient Shot By Police
The family of a mentally ill man shot and killed outside his house by Dallas police has released jarring video of the fatal confrontation as part of a federal civil rights lawsuit they filed against the department.
Depending on your point of view, the graphic footage shows cops badly bungling what should have been an routine attempt to subdue Jason Harrison, as his family contends, or it validates the officers' insistence that they were justified in killing the 38-year-old last summer.
Harrison, who was bipolar and schizophrenic, was gunned down by two officers responding to a domestic call on June 14, 2014 when he lunged at them with a screwdriver.
The family, who obtained video recorded by one officer's body camera, argues that the police used excessive force.
"This is a perfect video for the Dallas Police Department to use in training as an example of what not to do," older brother Sean Harrison told The Dallas Morning News. "You don't yell at them — that only agitates them."
Shirley Harrison called cops because her son was menacing her. In the newly released video, she's seen greeting police at her Oak Cliff, Tex., home.
Jason Harrison is right behind her, casually holding a screw driver in his hand, the video shows.
"Bipolar and schizo," Shirley Harrison tells cops as she steps outside.
The routine call escalates in an instant.
Officers John Rogers and Andrew Hutchins order Harrison to drop the tool.
"Drop that for me, guy," one officer tells Harrison as his partner draws his weapon. "Drop it."
Shirley Harrison can be heard yelling at her son to cooperate.
Harrison reportedly gets agitated; officers claim he lunges at them.
Jason Harrison, 38, was holding a screwdriver when he was shot by Dallas police. (Dallas Police Department)
Three shots ring out.
The video shows Harrison fall on the driveway against the garage door.
"When you're dealing with somebody who is mentally ill, you're not supposed to agitate!" Harrison family's attorney Geoff Henley told KHOU. "You're not supposed to move fast! You're not supposed to inflame."
Dallas police have said the video backs up the officers' accounts of the shooting, which they said was done in self-defense.
The Dallas County District Attorney's Office is reviewing the case.
Source: NYDailyNews.com
Date Posted: Wednesday, March 18th, 2015 , Total Page Views: 52173


Red Telephone Box : Wednesday Blog Hop..
"Parma Ham, Avocado, Crouton Salad…"
Great banners! Very creative. Wishing you a great weekend!
Sounds great, tea and brownie!! Thanks for the fun party!!
Love the meme today! Have a great weekend Claire!


I have created a custom field SnP users when i am updating the custom field , error is displayed. I have add -on script runner on the jira server even i have disabled the addon, the error remains the same.
indicates that this is a bug in some JIRA 7.4.x versions in regards to using a custom field of type user picker. Please see https://jira.atlassian.com/browse/JSWSERVER-16073 for more details.
From reading that description though you should be able to at least dismiss this warning and continue on that page. I realize this isn't ideal, but I would recommend watching that issue for updates or other possible work-around here.
Is this issue resolved in JIRA Software 7.5?
I wasn't sure of the answer here, so I went through and tested with with the Jira Software 7.5.0 version. In my testing I was able to recreate this specific error on the page. So to answer your question, No, this has not yet been resolved in the 7.5.0 release.
I would recommend watching https://jira.atlassian.com/browse/JSWSERVER-16073 for additional updates. I don't know exactly when this might be addressed, but when that issue is updated, it will indicate if this issue is being worked on, and what version will provide a fix for this error.
Thanks for assistance. Will follow the link above.
Issue seems to be still unresolved - just happened on my on-premise instance.


I can have a 7 ounce sirloin, saute'd garlic mushrooms, grilled onions and broccoli as my sides for 10g of carbs and 12g of fat. To me, that is acceptable, since 1 tbsp of butter is like 10g of fat and most "restricted" bars have at least 10g of carbs. Oh, and I get 35g of protein, which is kind of a major bonus for me.


My name is Karen Beran and I am a Title Reading teacher. I graduated from Illinois State University with a Bachelors degree in Elementary Education. I have endorsements in both reading and language arts. I previously taught second and third grade for six years. This is my second year as a Title teacher at Holy Family. I am married and have two daughters that attend Holy Family School. In my free time, I enjoy cooking, traveling, and reading.


N-Motion Auto Transport has Expanded its Services to Cater to the Heavy Haul Freight industry as well as the Car Shipping Industry. Welcome, N-Motion Freight!
Being centrally located in Houston, Texas, N-Motion Freight has easy access to incoming cargo from the Port of Houston and surrounding ports. This location also creates quick turn around transport times for the massive Texas oil field industry and its employees.
Being one of the world's best transportation providers doesn't happen overnight, but N-Motion Freight works hard every day for its customers in offering them a wide range of customized worldwide transportation and logistics solutions. The relationships that N-Motion Freight has built over the years with truck, oceanic, and air carriers = greater flexibility and multitude of equipment options to bring freight to the job site.
N-Motion Freight doesn't rely on one or even just a few carriers, which means we have countless options when it comes to solving each and every freight situation. N-Motion Freight's experience in the transportation industry makes it feasible to follow trends in the market and make informed decisions as to when surplus might be an issue. The ultimate goal is to leverage the purchasing strength in the market to give the customer the best available rates.
N-Motion Freight prides themselves in their cargo monitoring and quality reporting–keeping customers well-informed throughout the shipping process. For these demanding divisions, we provide 100% air ride equipment, including flatbed, step deck, dry van and lowboy trailers.


A 53-year-old Leominster man remains in critical condition today at UMass Memorial Medical Center — University Campus in Worcester after being injured in a motorcycle accident yesterday.
Michael J. Peete of 504 Prospect St., Leominster, was riding his 2007 Harley Davidson north on Route 70 about 4:15 p.m. when he crashed as he was trying to pass another vehicle, police said.
Route 70 was closed in both directions for two hours.
Boylston police and the state police reconstruction team are investigating.


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I was really impressed with the overall sound and quality of these IEM's. The spectrum was full with good low range extension but I really liked the mids and upper register in particular. Some IEM's can be a little harsh in this area but I found the AF1120 MK2 IEMs clean and clear and not hyped. I would say they take a little more driving than other IEM's we have used on the show but that was never a problem.
Build quality was good and of the 30 or so pairs we had, none of them experienced any problems.
The fit was also definitely in line with expectations. They were comfortable and secure and had differing sizes of ear buddies which suited all of the different ear canals. Only in the most extreme cases did the driver unit not fit snugly into an ear…some unusual ears out there! A little tape to secure them and away they went.
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Brydon Stace, Vocal Director and Director of Vocal and Music Production on ITV and Channel 9's The Voice Australia
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A stay at Trigong Residence places you in the heart of Chiang Mai, minutes from Wat Chiang Man and close to Chiang Mai City Arts & Cultural Center. This hotel is within close proximity of Three Kings Monument and Chang Puak Market.
Make yourself at home in one of the 17 air-conditioned rooms featuring refrigerators. Complimentary wireless Internet access keeps you connected, and cable programming is available for your entertainment. Private bathrooms with showers feature complimentary toiletries and hair dryers. Conveniences include desks and complimentary bottled water, and housekeeping is provided daily.
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HIGHLIGHTS: Coventry City 0-0 Stoke City
Coventry City fans can now watch the highlights as the Sky Blues and Stoke City played out a 0-0 draw at St Andrew's on Boxing Day.
It was the Sky Blues' third straight goalless draw at St Andrew's and the Potters third straight away goalless draw, in what was the first league meeting since 2008 between the two sides.
The returning Matty Godden came close for the Sky Blues in the first-half while Leo Ostigard's goal-bound effort was blocked in the second-half, while at the other end Steven Fletcher and Jordan Thompson went closest for the Potters.
After letting in 12 goals in their first five home league matches this season, Mark Robins' men have now let in just one in their last five at home and stay in 18th place in the Championship.
Stoke stay in seventh and chasing the Play-Offs, with the return game between the two sides taking place in April.
You can watch the highlights from game below, or by clicking here.
The Sky Blues' next game is Tuesday night's away trip to Preston North End.