In order to obtain Cristina Configurable Living Room Set By Fleur De Lis Living , search for quality hardwood joinery. When a item is glued together or if fingernails and anchoring screws are widely used to maintain the furniture with each other, it does not final lengthy. It is recommended to spend more to obtain a Cristina Configurable Living Room Set By Fleur De Lis Living with some outstanding hardwood joinery work on it. Truly consider the thighs and legs associated with a Cristina Configurable Living Room Set By Fleur De Lis Living you are interested in purchasing. Individuals hip and legs will need to not only assistance body weight, they'll be also in touch with your floor coverings. If they appear like they'll do harm to your flooring as a result of components applied (like aluminum), then you really should opt for a different fashion. When purchasing Cristina Configurable Living Room Set By Fleur De Lis Living for your living room area, choose neutral colors. You may modify the colours as well as other furnishings of the place by transforming decorations, paint along with other stuff. Consequently, it is possible to modify up the appearance of your family room without spending lots of money.
An elegant and stylish dining table can acquire the most out of any meal you enjoy with friends or family. Within the specific the event of friends, they will most likely assess you by how neat and classy your dining area- dining table- looks. Are you thinking of purchasing new furniture for your kitchen or dining room? This short article will help you to test the very best best ten modern platforms in 2018 evaluations. Some of the factors that established the search positions for these products consist of, but not restricted to, versatility, design, comfort and ease, dimension, materials utilized, and whether or not the table includes chairs. The types of materials mostly considered are metal and wooden as the size is a measure of how lots of people a particular desk can hold comfortably.
The term this is actually the comfort and sophisticated look. This established includes a tufted back rest and nail head accent that provides the sophisticated look. Its gray colour adds to its impressive appear. It may fit as much as 8 inches bed mattress. That on your own lets you know how comfy the established could be. Particularly, it doesn't include a mattress. So you may want to buy one. The trundle includes a castor to allow quick access. You may even draw the trundle for people to sit on. Just to point out, it should take putting together, however its very easy to assemble.
When it comes to purchasing living room furniture, leather is definitely a good option. It doesn't only look good with most designs, nevertheless its extremely long lasting (its the perfect materials for any home with children or animals) and its extremely-easy to thoroughly clean, too. The down-side of leather Linden Ladder Bookcase? It can have a higher cost than fabric, micro-fiber or fake leather Linden Ladder Bookcase. This lying loveseat stays a budget-pleasant choice due to 1 guru trick: its sitting area is upholstered with leather-based, while the attributes are padded with more affordable faux leather. Which means you receive the look and feel of the full leather loveseat with no significant cost. Make use of the lever around the loveseats equip to kick back and take it easy on its high-density foam filling, and think about all the money you saved. This particular loveseat posseses an added bonus: professional set up is available in numerous locations of the country for the next fee.
This set is padded in a drive and comfy textured padded purple velvet. This provides it the incredible comfort and ease that it is loved for. Once again it facilitates chaise design seating for sufficient comfort. Furthermore, the sinus spring foundation increases the durability and comfort. Furthermore, the couch has hardwood structures that increase its toughness and sturdiness. The couch has soft cushions on the seat and the back. But still, the sofa can change from a seated position to some lying down placement easily. That said, simply to replicate, the couch is very soft and provides outstanding comfort.
When the Chesterfield is the elegant man amongst couches, the Cabriole may be the grande dame. Noted for its exposed wood and stylish thighs, reminiscent of the Louis XV time period, the cabriole also has a unique silhouette. It had been additionally a popular form within the work of Americana Oversized Set Bookcase maker Thomas Chippendale. Usually, the back is 1 constant item with out soft cushions and it has a stylish bending line. This specific cabriole version includes gems in the tufts for added glamour. It's a couch style that can be as basic or opulent as you desire. Upholstered with a luxury material like velvet produces a significantly different style sensation than whether it were padded inside a much more moderate, textural natural. The main aura of elegance stems from its general shape and lithe thighs meaning it'll always lend a processed atmosphere to a space.
This is definitely the cutest and cleverly designed loveseat. Depending in the shade, it provides a disturbing appearance for your workplace or areas. The sofa unimaginably imperceptible for a early morning java or an computer animated magazine studying very carefully. It is accessible in leather as well as in texture based on what you assistance a bright look, or a beautiful, beautiful look at. The best part, it is very reasonable! The super stylish tufting is molded precious stone, which holds an exquisite Chesterfield design. Probably the most adorable point about this couch is its shape. Combined with the appeal, the trunk style provides the back knowledge of rest. It's skillfully created to ensure that smaller sized rooms consolidate extravagance inside a smaller sized space. It is a smart choice for the childrens room, as it offers several fairly sweet tones. They would like to hit them for reading the story or for a fantastic dream. No trouble for adults as well for any comfortable night with Manga or Marvels.
Typically now used in houses with a living room or open layout, they are often large designs that seat lots of guests. In smaller rooms, they works well for seats in an area which has a strange corner or other room limitation. The ability to mix part models, finish models and reclining sections based on space and person choice makes this sofa design super flexible. Sectional couches also come in a multitude of styles, from extremely contemporary or super luxe, to more family-friendly contemporary designs.
Usually now used in homes having a great room or open layout, they are often large designs that chair lots of guests. In smaller rooms, they works well for seating in an area which has a strange part or other room restriction. The ability to mix corner models, finish units and reclining areas based on room and individual choice tends to make this sofa style super versatile. Sofa sofas are also available in a wide variety of designs, from extremely contemporary or extremely luxe, to more loved ones-friendly modern styles.
This RTA loveseat offers different types of upholstery with respect to the materials. That significantly incorporates bed linen and purple velvet. Sophisticated tones, Marzipan, Stoneware-Beige and Rye-Dark brown improve design for the couch. Select the shading and the material that will depend on the stylistic design of your room. Not only the shading, the material can also reflect the main difference in style. Make sure that the material you choose matches the theme of your space. This loveseat ballots in favor of combining the present style with an exemplary design. It has been moved up by the hands that begin to feed the sofa. With this mix, you simply witness enhanced comfort and ease and stylish style when lighting the patches.
You cant discuss this sofa with out referring to its remarkable style, durability, and luxury. If you ever needed a comfortable chair, then transfer quick and get your self Coaster Samuel Selection Lotion Leather-based Sofa. You'll like it. This 3 seater sofa has clean outlines and excellent cushions. The soft cushions are affixed to the seat and at the back. It is made of leather and that definitely is a sure wager that it is long lasting. Additionally, it features tufted back again and chairs that definitely adds to its remarkable look. More to the point, it has a springtime base that gives it the required durability and comfort. Its wooden frame makes it really sturdy. The long and the short of it is that this sofa is remarkable in each and every element. You might or might not agree with this. But the only method you can understand why is to buy and check out it.
This set is upholstered in a drive and comfy textured cushioned velvet. This gives it the incredible comfort and ease that its loved for. Again it facilitates chaise design seats for adequate comfort. Moreover, the nose springtime base adds to the durability and comfort. Furthermore, the sofa has hardwood structures that increase its sturdiness and durability. The sofa has soft cushions on the chair and the back again. Yet still, the couch can move from a seated placement to some reclined placement easily. That said, simply to replicate, the sofa is extremely gentle and gives exceptional comfort.
Overall, this kind of unique table for coffee certainly brings consumer advantages of example, it is mild and easy to mobilize. You can use it for many promises such as family room table, study or work table, and much more. Simultaneously, you've currently observed several coffee tables previously mentioned. Each of them is exclusive with the making of wooden furniture, stainless steel a coffee table, and cup leading a coffee table.


If you're looking for a vintage-inspired eyewear look that is unique and stylish yet still practical, then look no further than these one-of-a-kind specs designed by comedian Rickey Smiley for Eyeglass World.
The black color of these frames is neutral enough, and the shape is certainly classic. But the white interior contrasts to bring a modern look, and then the faux wood finish creates a vintage feel.


This sample of ilmenite is displayed in the Smithsonian Museum of Natural History. Ilmenite is an oxide mineral of titanium and iron with the composition FeTiO3 . This sample is about 6x5 cm with the crystal about 1 cm. It is from Bagicha, Tormiq, Baltistan, Northern Areas, Pakistan. It is described as ilmenite with albite.
This ilmenite sample is from Snarum, Norway and is about 12 cm across.


For the second year in a row our church, More, held a Seter Supper to commemerate The Passover. Michael and I were not able to attend last years event because we had just had Ephraim and I was too terrified to breast feed anywhere but my own home. Needless to say, we were both very excited to celebrate the Seter with our tribe. This was not my first Seter. My family used to have a Passover meal as part of our home group when I was a kid. This Seter I was very excited to experience having been to Israel two years ago and experiencing the Holy Land firsthand.
The menu for the meal was already set, there would be lamb and brisket, green beans and the rest were traditional Jewish delicacies like Matza Ball soup, Matza muffins, and Blintzes. Several women in the church were asked to prepare these cultural favorites and I was one of them. I was assigned the blintzes which apparently are similar to a crepe. I have never made a crepe, but I knew it was like a small, paper thin pancake. I also knew that crepes were fairly difficult to master. Oh well, how hard could it be? Famous last words.
I should have known I was in trouble when I was instructed that these had to be made the same day as the Seter. They couldn't be made ahead of time like some of the other baked goods. I also should have known when my phone started ringing at 10:00 a.m. and found some of the other women assigned to make the blintzes frantic on the other end of the line. I had a doctors appointment that morning and was not able to get the project underway until about 1:00 that afternoon. Just as I was beginning to start the process my mother called (who was sort of in charge of the blintz making) saying not to use the original recipe. She was bringing me a new recipe and some additional ingredients: potato flour and matza meal as well as another 2 dozen eggs. Apparently the Jews really like to use eggs. Mom showed up about 2 o'clock and I started the blintzes.
The basic directions were to whisk 6 eggs until light and fluffy and then add them, along with 1 1/2 cups of water, to the matza meal and potato flour that had already been sifted together. The directions said to blend until smooth. I am pretty sure I could have blended for hours and that mixture was never going to get smooth. It was a nasty, lumpy mess. The only thing I knew to do was keep adding water. That seemed to help thin them out, but when placed on the griddle they would only cook on one side. I had no choice but to flip them and cook on the other side as well. This would have been fine, except that once all the blintzes were cooked and cooled they were to be stuffed with a cheese mixture and then wrapped (folded up) and fried in oil (oh joy). Since they had been cooked on both sides already it made the process of wrapping them very difficult. When I tried to fold them up they would start to break and the cheese mixture would run out into the oil. It was becoming quite clear that these blintzes were not going to work out as intended. I finally decided that I would just bring the flat, pancake like blintz thingies to the church in a big casserole dish and bring the stuffing mixture in a seperate bowl. I figured if anyone wanted to actually risk eating these things they could just get a pancake and spoon the cheese mixture on top.
Somewhere in the middle of all this chaos Ephraim awoke early from his nap. I had no choice but to get him up and put him into his pack-n-play, which I had moved into the kitchen. He pretty much just sat there and watched his frazzled and filthy mother stomp around her stinky, messy kitchen trying in vain to salvage the blintzes. Finally, Michael came home and was able to take over Ephraim duties while I finished up. Michael took him out in the backyard to swing while I continued cooking. It was during this time that I made the decision to put all the cooked blintzes into the casserole dish. I had no available counter space so I moved the dish to our pub table. About this time Michael came in with E and put him back into the pack-n-play. He also moved it slightly backward, toward the pub table. I am sure you can imagine what came next. Yep, Ephraim reached a little paw out of his pen and grabbed the aluminum casserole pan, pulled on it and dumped all the contents onto the floor. I didn't know whether to laugh, scream or cry. I think I did all three. I decided not to completely freak out and knew I had one of two choices: employ the less than 10 seconds rule and figure what unsuspecting eaters don't know can't hurt them -or- chalk this event up to fate and know that my son just saved me from forcing 200 of my favorite people from ingesting food that was slightly less than edible. I opted for choice number two. I loaded the 20 or so completed blintzes into a new casserole pan and headed to the church. The Seter started at 6:30, we arrived at 6:15.
Thank God this was a real Seter and we used real wine, not grape juice. I don't think I have ever needed a stiff drink more!
The evening was amazing. The ceremonial acts and recitations were so incredibly moving. If you have never celebrated a Passover Seter I encourage you to find one to participate in next year. It is truly wonderful. Just don't let anyone talk you into making the blintzes!
Here are some pictures of the days destruction!


Large gun safes – There are several things to consider when shopping for the best gun safe to suit your needs, as well as other major purchase, you want to do a lot of research to ensure you make the right decision. If you are just starting your job may seem a bit overwhelming at first, but once you understand the basics, making your decision making process should be much easier.
Large gun safes optimally dimension ed so as to be able to comfortably accommodate your entire collection of weapons and weapon-related accessories with you without being too cluttered or messy. There are various sizes to consider, and some gun safes marked with the maximum number of weapons they are able to lead, and it can range from under 10 to over 65. One of the biggest disappointments of people who have after buying a small is their wish they bought a bigger one.
This is because, as soon find there are so many non-gun related valuables will be safe in your gun as well. Large gun safes are great if you have a number of weapons, ammunition, weapons and other accessories for it to continue. But if you have only one weapon, or would like to guns separated from the rest of your collection, you can also consider gun safe. They are much smaller than normal, and gun safes are easily hidden in a closet or under the bed.


Turn the printer off, hold down the feed button and turn the printer back on, continue to hold the feed button. The printer will print out two slips of paper showing the configuration of the printer. The second printout is a network configuration sheet showing the ip address of the printer.
Clean the printer. Use the printer's self-cleaning feature usually found under the driver's "Utilities" or the printer's "Properties" section. Click "Clean Print Heads." Or get a dry, lint free cloth and gently wipe down any accessible parts.
The TSP100ECO, the world's first ECO POS printer, further extends the legacy that is the TSP100 futurePRNT. The TSP100ECO supports Star's commitment to being ecologically responsible, while allowing Star to continue to provide a high-speed, software enriched, economical choice for users.
Printer is exactly as described. What a great price! We had it installed by our computer guy in a few minutes. It is a slightly newer model than the one we had previously but the ink ribbons, paper and the cable hookups all work perfectly with the new printer.
Check the ink. Most newer models will tell you if the ink is low, but try running a color test to double check. You can usually pinpoint the faulty cartridge with this test and then either replace or clean it.
EPSON TMU220B M188B 653 Serial Receipt Printer. These printers are fully cleaned, fully tested and in excellent working condition. A Power supply and power cable will also be included with your purchase. Also, your printer will come with a new ink ribbon installed, and will be shipped with test pages inside of printer.
Adding to the environmentally friendly design is the TSP100ECO's cover unit. The cover unit is manufactured with Halogen-Free recyled plastics. The packaging each printer is shipped in is also recyled and eco-friendly.


Another lovely page by the incredibly talented K. Lynn Smith of Plume!
Sings-to-Moon is not just elusive. She's also suspicious, cautious, and patient. See that patience in action when you vote for Snow by Night on Top Web Comics!
Is that the 'seal of approval' in the last panel?
It might be! It's also Plays-in-Waves, who was mentioned on Page 10 of a Berry from the Sun.
Wow.. I love and hate you at the same time.
Warranty void if seal broken.
We may have a sealious problem on our hands.
So spirits can feel loss, they just don't connect with humans as well as each other. I want to know if Sings-to-Moon can help, since she lost her hand helping her with this.
Of course they don't connect well to humans – human lives are short as fruit flies to them.
Also, I see what you did in that last panel. I love a good pun (really), but it seems out of place in this comic, and especially at this moment.
I'm not entirely sure, so I'll assume that your comment is directed at the page itself and not at one of the commenters. There is no pun on this page. The image of the seal is a reference to Plays-in-Waves, a seal manitou, who hid the mask away at the end of A Berry from the Sun back in Chapter 10.
Of course there's a pun. Sings-to-Moon says they need to _seal_ the mask away, and this comment is accompanied by the image of a seal.
Huh. I never noticed that before. That was entirely unintentional.
FMA is pretty awesome! I'm glad you got re-oriented. I haven't tried to read SbN from right to left yet. I would think, it would be a very bizarre story.
Again Sings-to Moon looks so cute here. Ahh can't get enough of them cuteness.


text:
Supply issues top CPG company leaders' concerns, study finds
Supply chain disruptions have become the top concern for most food, beverage and dietary supplement leaders, with 58% ranking it as their biggest challenge, according to a survey done in June by TraceGains. More than six out of 10 business leaders said they have changed at least six product recipes or formulations in the last two years, with 37% having to modify 20 or more.
Nine out of 10 leaders said they've paid more for ingredients and materials in the last two years, and 65% have increased their prices. But 49% have halted production of specific items, with nearly as many saying they are unable to meet consumer demand.
Product shortages and price increases have dominated business outlooks and earnings calls for the last six months as CPGs look to balance sales and profits during an uncertain economic period.
No studies are needed to show that many CPG leaders are worried about supply chain issues, but this new report from TraceGains shows just how deep these issues are cutting into corporate operations.
According to the study — conducted last month through a survey of more than 300 business professionals at U.S.-based companies with annual sales of more than $500 million — the perpetual concern of quickly changing consumer preferences is now at the bottom of the list of things that leaders worry about. After supply chain issues, the survey found, leaders said their top concerns are labor costs, uncertainty and difficulty planning and forecasting and materials costs — and then consumer preferences.
Almost 70% of CPG business leaders surveyed said they plan to increase their supplier diversity in the next two years as a long-term way to deal with uncertainty. Leaders in other manufacturing sectors have been feeling the same way. According to the 2021 BDO Manufacturing CFO Outlook Survey, half of middle-market manufacturers planned to identify alternative or backup suppliers last year.
But adding different suppliers to a manufacturer's mix could force slight reformulations on products — though this survey shows taking that action has become a commonly used tool to blunt the impact of inflation. While reformulating products to make them more nutritious or more sustainable gets the bulk of the attention in the food business, these types of reformulations go under the radar.
Changing only slight features of the product — different varieties of grains, shifting the amount of ingredients used, or completely doing away with certain ingredients — does not always require dramatic changes to product labels. It also may not significantly alter the taste, texture and appearance of the finished product.
This kind of supply uncertainty also creates opportunities tailor-made for today's big ingredients companies. Earlier this year, Ingredion CEO Jim Zallie said in an interview that the current situation leads manufacturers to enter into supply agreements more quickly.
The larger players in the ingredients space — including Ingredion, Kerry and International Flavors & Fragrances — have been active in M&A during the last few years. The added scale increases the likelihood that they can be a "one-stop shop" for a manufacturer. Food and beverage makers also are more willing to partner with the formulation teams at ingredients companies for quick innovation, creating a tighter relationship between the companies. Zallie described this as "a win for them, a win for us."
These kinds of arrangements are especially important because the TraceGains survey showed innovation is not necessarily slowing down right now.
While 35% of respondents said their innovation had slowed during the pandemic, 36% said their efforts had accelerated. This could be a smart business move right now. As consumers are being more careful with their money, they're showing they are less loyal to specific brands and products. But a new twist on a beloved brand could reinvigorate interest and make a consumer feel like it's worth paying for, even if the name-brand option is more expensive.
Lawsuit claims artificial coloring in Skittles makes them 'unfit for human consumption' →
← Disney Wish Food: What to Eat on Disney's Newest Cruise Ship

redpajama_set_name: RedPajamaCommonCrawl


text:
German States
Medal of Honour
Type I (1809)
Medal of Honour in Silver, Type I
Product version - Medal of Honour in Silver, Type I
SKU: 02.FRK.0101.102.01.000
Obv: CARL THEODOR FÜRST PRIMAS Rev: DAS VATERLAND SEINEM TAPFEREN VERTHEIDIGER
Physical Description and Item Details
A circular medal constructed of silver. The obverse bears the bust of Prince-Primate Carl Theodor von Dalberg encompassed with the inscription "CARL THEODOR FÜRST PRIMAS". The reverse bears the inscription "DAS VATERLAND SEINEM TAPFEREN VERTHEIDIGER" (from the fatherland to its brave defender) encompassed by a wreath of laurel. On a loop for suspension, with a red ribbon. Weighing 23 grams.
The Medal of Honour was established by Prince-Primate Carl Theodor von Dalberg in 1809. The medal was conferred upon members of the military who fought in Spain during the Peninsular War (1808-1814). Troops that fought in Spain suffered heavy losses under French command. Several commanders suggested to the Prince-Primate that a medal be commissioned for those fighting in the war.
Conrad Christian L'Allemand, Frankfurt was commissioned to produce the stamps for the medals. They were available on July 1, 1809. Initially, six gold and twelve silver medals were to be minted by Johann Georg Bunsen, Frankfurt, but the stamps had to be redone and it wasn't until September 30, 1809 that the first seven gold and 20 silver medals were minted. On October 17, 1809, Prince-Primate Carl ordered for 12 more gold and 24 silver medals to be minted. On January 29, 1810 the first award ceremony of six gold and 17 silver medals took place.
The Prince-Primate became the Grand Duke and new stamps had to be created. With the new stamps, six gold and 13 silver medals were minted.
Only 20 Type I Silver Medals were conferred.


Please take another look and offer any comments on colour pics words etc cheers.
I've seen in used in the sense of "At thesec prices, we're practically giving them away!", but yes, it does have the possibiltiy of confusion.
Here's a very rough idea of what it would look like with the skull and cross candy canes instead of the dog, and the chino image replaced with a back shot. Just messing around to see what it would look like with two wide leg shots, and a front and rear shot instead of two front on shots.
Apologies if I'm stepping on toes editing artwork, no offence intended... just thought a visual example could make assessing possible designs easier.
Here is the text. How does it read. What isn't working for you? What would you prefer to be mentioned?
XMAS SJC Big B Dungaree Offer.
Modelled on the wide leg 4 pocket dungaree of 1930's (plus coin pocket). These are not jeans but pants with a high rise, a full leg and move beautifully. Generously cut around the hips they capture the Dustbowl vibe and look great on both boys and girls.
The Big B's feature deep 12oz sailcloth pockets and are held together with the thick cotton, bartacks and feature subtle top stitching details. They are stylish enough to be worn in the office, out at night, but also hard wearing enough for any manual work.
Available in denim or 12oz Chino. or our slubby 15oz Thai denim, identical to the Okinawa, but very soft. The denim has had a cold soak so minimal shrinkage, order your true size.
SJC suggests that a wide leg should be worn uncuffed. But that is up to you. Either way measure a pair of jeans that fit very well from the crotch seam to the hem and add your cuff length if you want, we will chain stitch them for free to your length.
And here it is: SJC is offering you two for the price of one, or just £99 each. So order a pair in Chino and Denim, or Chino and Chino (you always need a backup pair). Or Denim or Denim. Get both for yourself. Or one for you and one for your friend. Yes, we've thought of that too. Download the SJC Big B Xmas Card, print it on some heavy paper and give it to your friend this season telling them you've brought them something special.
These will be made in Jan and shipped in Feb.
Looks good. Any danger of "boys and girls" being misread as "in kids' sizes", or am I over-thinking it?
No offense taken, swinglish. Design away. I was just thinking: "No Logo?" but SJC is an extraordinary sales model and it will be promoted on the own page so I guess it's OK.
The text with comments in red.
Modelled on the wide leg 4 pocket dungaree of 1930's (plus coin pocket). These are not cut like ordinary jeans but pants with a high rise, a full leg and move beautifully. Generously cut around the hips they capture the Dustbowl vibe and look great on both boys and girls.
Available in denim or 12oz Chino. or our slubby 15oz Thai denim, identical to the Okinawa (I wouldn't mention it. sounds like second choice really) , but very soft. The denim has had a cold soak so minimal shrinkage, order your true size.
And here it is: SJC is offering you two for the price of one (name final price! too confusing otherwise), or just £99 each. So order a pair in Chino and Denim, or Chino and Chino (you always need a backup pair). Or Denim and Denim. Get both for yourself. Or one for you and one for your friend. Yes, we've thought of that too. Download the SJC Big B Xmas Card, print it on some heavy paper and give it to your friend this season telling them you've brought them something special.
PS: Working on new versions of the Big B add this evening.
This is fantastic Simon. Great idea. I might have to jump on a pair of the chinos. I've really been wanting those. Unkraut great job on the advert! This should really help us reel in some more folks.
(12-07-2015, 05:25 PM)Edward Wrote: Looks good. Any danger of "boys and girls" being misread as "in kids' sizes", or am I over-thinking it?
Maybe a little. Once they check the sizing chart it might clear it up. Maybe Guys and Dolls or something. I don't know if it's a big issue.
Maybe it's best to not mention gender at all? Stick to mentioning a wide range of sizes and avoid any confusion with regard to specific male / female cuts?
Please give me feedback on experience and glitches etc.


The data of the 1981-83 Swiss National Health Survey "SOMIPOPS", based on a randomly selected sample of 4,235 individuals aged 20 or over representative of the whole Swiss population, were used to investigate the relation between smoking, prevalence of disease and frequency of health care utilization. The risks of several conditions, including hypertension, myocardial infarction and other heart diseases, asthma, tuberculosis and kidney disease were elevated among ex-smokers. The diseases showing elevated risks among current smokers and significantly positive dose-risk trends included acute bronchitis (relative risk, RR = 3.2 for heavy cigarette smokers vs never smokers), chronic bronchitis or lung emphysema (RR = 2.0), gastro-duodenal ulcer (RR = 1.8) and bone fractures (RR = 1.6). For respiratory conditions, the risk of pipe or cigar smokers was comparable to that of moderate cigarette smokers, whereas for ulcer (RR = 4.1) or fractures (RR = 2.0) the point estimates were even higher than for heavy cigarette smokers. Smokers tended to consult more frequently general practitioners, used more other outpatients services, and were more frequently admitted to hospital during the year preceding the interview. These effects were consistent across strata of age, socio-economic indicators, and persisted after allowance for major identified potential distorting factors. Thus, the results of this survey confirm that smoking is an important cause of morbidity and a major contributory factor to the use of health services.


The beautiful Grimm's Semi Circles are the perfect add-on to your existing Grimm's Rainbow. Combine them to create a tower featuring several platforms and rooms, or use the Semi-Circles individually on the floor to create a geometric artwork.
Being hand-finished, each of Grimm's beautiful offerings is unique, with slightly different shaping, wood markings, grain, and knots. Please note they are not varnished nor lacquered. The Natural Semi Circles are made from a plywood, not timber.
Please note the Grimm's Rainbows and other accessories shown in the pictures with the Semi Circles are not included.


Recognised by Channel News Asia as "South East Asia's First Professional Female Magician", Ning Cai has also been credited by media and magic organisations around the world for constantly pushing boundaries and popularising the traditionally male dominated art of magic.
After putting herself through night classes at Uni and having her last $300 in the bank, Ning realized that her heart was her best GPS, so she decided to take the plunge in becoming a professional illusionist/escape artist after graduating with her BA in Mass Communications from RMIT. Back then, as sole breadwinner of a family of 5 with her two sisters still in school, Ning's hunger for success fueled her.
She didn't expect it but through blood, sweat and tears (backstage - where nobody sees the true happenings behind the scenes), the tenacious Singaporean evolved into an international artiste who has entertained royalty in Oman; been watched on stage and television by millions in Japan, France, Italy, Kuwait, England, China, Indonesia, Malaysia and Singapore; also performing complex and newsworthy mega illusions 'live' before crowds of 12,000 at major events like the National Heritage Board's Singapore Night Festival, Singapore Press Holding's Straits Times: Part of My Life, the Singapore Tourism Board's Singapore River Festival and more.
An honoree of the Singapore Women's Weekly's "Great Women of Our Time" and ambassador for Singapore's official "Power Over Cervical Cancer" (POCC) awareness campaign, Ning has always been a strong proponent of "girl power". She has spoken about it at Passion:Unleashed and Tedx.
A cancer survivor herself, Ning regards her close brush with death at 21 as a powerful catalyst that inspired her to start living and not simply exist. She passionately believes in paying it forward and has worked on several projects for Sharity Elephant, the Children's Cancer Foundation and had also supported a Mongolian child through World Vision. Ning was also involved in the Best of You social movement, inspiring kind acts through art and real life stories.
A published author who is often invited to share at Singapore Writer's Festival and National Library Board events, Ning's latest book was recently nominated for the Singapore Literature Prize 2016. She has 2 more books coming out at the end of the year... and many more tricks up her sleeve.


text:
Nurses Most Ethical Profession, Americans Say
Gabriel Perna
Healthcare Reform, Malpractice, Population Health, Staff
Physicians Practice
Welcome to Practice Rounds, our weekly column exploring what's being covered in the larger world of healthcare.
In Nurses We Trust
Gallup polled 1,028 Americans aged 18 and older on what professions they find most and least ethical. Healthcare providers in general ranked fairly high, but nurses took the top spot. Eighty-four percent of Americans rated nurses' ethical standards as "high" or "very high." After that, pharmacists ranked second (67 percent) and medical doctors ranked third (65 percent). Coming in last place was members of Congress. Only 8 percent of people polled by Gallup said Congress' ethical standards were "high" or "very high." HMO managers had the lowest ranking of any healthcare professional at 12 percent. For full results of the survey, click here.
Repealing Obamacare a Challenge for GOP
With President-elect Donald Trump set to take office in two weeks, Republican members of Congress began laying out a plan to repeal the Affordable Care Act. While they agree that the health law needs to go, Kaiser Health News reports that they have yet to come to a consensus on how to do that. Repealing the law outright could cause 20 million Americans to lose coverage and lead to heavy backlash from the public, so Kaiser Health News says Republicans are looking at various ways to disassemble it carefully. "It's not that Republicans don't have replacement bills. They have a couple dozen. The problem is they don't have consensus," Douglas Badger, who oversaw health policy for President George W. Bush, said at a recent policy forum, according to Kaiser Health News.
Is There a Malpractice Crisis?
Many top Republicans see a major issue in healthcare: a wave of frivolous malpractice lawsuits that threaten the U.S. health system, reports California Healthline. For this reason, top Republicans, House Speaker Paul Ryan and Rep. Tom Price, who is slated to be the Secretary of Health and Human Services, have vowed to make tort reform a part of their package replacing the ACA. However, California Healthline talked with malpractice experts who dispute this claim. "It's a time of relative calm and this hasn't been a front burner issue or crisis," Nicholas Pace, a researcher who studies the civil justice system at the Rand Corp., a nonprofit think tank, told the publication.
Value-Based Care is Going Nowhere
While Trump's rise to power alongside a Republican-led Congress will undoubtedly have a major impact on the ACA and other aspects of the health industry, Joe Guerriero, senior vice president of MDGuidelines, writes in Managed Health Executive that value-based care won't be part of that change. Guerriero says that if the ACA is not fully repealed, many of the parts surrounding value-based care will be kept. He also points to the Medicare Access and CHIP Reauthorization Act of 2015 (MACRA), which was a bipartisan law and expected to unfold as planned. The enactment of this law will "considerably raise the stakes for value-based care," he writes.
Finding Empathy for Patients on a Difficult Day
"We are all recipients of patient 'dumps' (which is a really unfortunate way to describe the care of a fellow human being). Our colleagues disappoint us. Our staff disappoints us. We disappoint ourselves. Medicine is hard work and each patient encounter requires your full attention, compassion, intellect, and skill."
Jennifer Frank, family physician in northeastern Wisconsin


I have purchased and will be recieving my usbuirt tonight.
Pardon my ignorance, but what next? Do I need to purchase anything else, or is it just complete the templates, and go from there?
If anyone can point me to some documentation, or send me in the right direction it would be greatly appreciated.
I ordered two Hauppauge PVR-150's that come with the MCE remote and kit. Will I have any trouble getting things set up for the transmitters that come with that kit to control my satellite boxes (2 identical ones, one installed on the core and one installed on the MediaDirector)? Or, should I have gone with the plane-jane version of the PVR-150 and grabbed one or more USBUIRTs? Can a USBUIRT control multiple devices? Multiple identical devices?
You will need a remote to use with your usbuirt. We use MCE remotes. Just plug the usbuirt in and it will be PnP... your MD or Core will auto-detect it and will auto-add an MCE remote too. Once the 'Adding software....' messages in the top left of the Orbiter screen have cleared you should have a working remote.
IR Blasting (ie controlling external IR equipped hardware) using emulated IR commands can be setup using setup Wizard.
Am I missing something or just setting up something incorrectly?
There was no template for my tv, so I created one, I had it learn the code for power and it appeared to do so successfully. However when I tried to test it, It did not work.
Are you using an ir emitter or serial cable to control your tv?
My TV does not have serial. The only thing I have is the USBIRT, do I need something else?
I just got my USBUIRT hooked up, and I'm also scratching my head over this. It got detected when I plugged it in. Now, setting up a TV seems almost impossible.
I get to the part where you can select "Learn Code" and nothing happens when I repeatedly press the power button on my remote.
There is absolutely nothing in the Wiki about getting this set up. Can anybody write a decent tutorial?
Re: USBUIRT now what? MCE USB now what?
i have the same experience with the MCE USB receiver without the external emitters.
Does someone know, if that thing does work WITHOUT the ext. emitters?
Yes it does, I tested with a win application and it learn any codes from my remotes and then transmit them without an external emitter.
I think the problem could be in some settigs lost some where.
the application if you want to try it is lrnhelper.exe.
I have the same problem.. I've spent the last 2 weeks trying to get my external satellite box to tune to channels from MythTV, but no matter what i do, the channel does not change (and my USBUIRT light does not flash, so it is not even trying to tell the channel to turn). My satellite box did not have a template, so I had to make one myself. I wonder if there is some setting that we are all missing in the device template when we create the device... Does anyone know, as mythtv is pretty much useless if I can' change the channels from any room.
Did you find an answer to controlling multiple identical devices? I would like to get dish/directv and put at least 2 cable boxes in a closet with the core. Then, have remotes on the media directors be able to watch/change channels and record what I choose. Ideally, I could put the cable/dsl modem, core, cable boxes, whatever in one closed with a dedicated circuit break for that closet and AC to keep it cool.
Anyone with a similar setup?


If you have any hardware in your studio (which you probably do), you need this stuff! Invaluable for cleaning pots, switches, jacks, and everything electronic. Also great for electric guitars and basses and amps.


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"An alternate to socio-political paradigm of Pakistan."
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Home News Fastest Fifty in ODI: Five Players Who Have Broken Shahid Afridi's Record!
Fastest Fifty in ODI: Five Players Who Have Broken Shahid Afridi's Record!
Saqib Ali
As of now, there are five players who have broken Shahid Afridi's record for the fastest fifty in ODI. However, Afridi is still an exception because he matched that record multiple times. According to the statistics, it took Shahid Afridi 18 balls to score a fifty in these records.
The first time he claimed this record was during Pakistan's encounter with Sri-Lanka at the venue of Nairobi in 1996. Afridi proceeded to set the bar high and crossed 50 runs within a matter of 18 balls in total.
The second time Afridi did this was during Pakistan's encounter with the Netherlands at Colombo. This match took place in 2002 and according to the scorecard, Afridi matched up to his previous record of 50+ runs in 18 balls.
Third time's a charm, isn't it? Well, Afridi once again became a claimant to this record by playing against Bangladesh at the venue of Dhaka. The match was conducted in 2014 in which Afridi once again went on to make more than 50 runs in 18 balls.
However, Afridi has been outperformed by various cricketers on this record. There are currently five players who have successfully matched or broken Afridi's infamous record.
1. Simon O'Donnell (18 balls)
The power hitter from Australia took no step backwards when playing against Sri-Lanka at Sharjah. In 1990, even before Afridi, Simon secured more than 50 runs in just 18 balls. Afridi himself had matched this same record.
2. Sanath Jayasuriya (17 balls)
Soon after Afridi became a claimant to fastest fifty. Sanath Jayasuriya, a Sri-Lankan batsman, broke the barrier of 18 balls and went on to secure a 50 in just around 17 balls. With a definitive 1 ball margin, Sanath reigned as the fastest fifty makers in the ODI for more than a decade. Coincidentally, the fifty was made against Pakistan at the venue of Singapore. In 1996, Sanath batted against Pakistan and made his way onto the list.
Source: Google Images. Labelled for reuse.
3. Kusal Perera (17 balls)
Second Sri-Lankan on this list and third batsman overall, Kusal Perera also scored his fastest fifty in just 17 balls. This fifty was also scored against Pakistan but almost two decades later at the venue of Kandy in 2015.
4. Martin Guptil (17 balls)
Another Australian making his name on the list is Martin Guptill. Guptill played against Sri-Lanka at the venue of Christchurch in 2015-2016. Guptill went on to strike hard against Sri-Lankans and match against their own record of fastest fifty. He made more than 50 runs in just 17 balls.
5. The Reigning Champ AB de Villiers (16 balls)
AB de Villiers, a South African batsman, made history at the venue of Johannesburg by scoring 50 runs in just 16 balls. He annihilated West Indies team in 2014-2015 by smashing back to back boundaries and breaking the barrier of 17 balls. De Villiers still remains the reigning champ of this record for the past 5 years. Some attribute the sheer skill of AB while some say it was an advantage of playing on home ground. Regardless of the opinions, AB de Villiers has written his name in the books of cricket history.
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Spicolli ha lottato in Messico col nome Madonna's Boyfriend e in federazioni statunitensi come World Wrestling Federation, Extreme Championship Wrestling e World Championship Wrestling negli anni novanta. È stato trovato morto il 15 febbraio per un'overdose di droga.

Carriera

World Wrestling Federation
Nell'aprile 1995, la WWF "riconfezionò" Spicolli con la gimmick di "Rad Radford", un fan della musica grunge, presunto "nuovo fidanzato" di Courtney Love (kayfabe). Prese parte a un angle con The Bodydonnas, tag team nel quale egli voleva disperatamente entrare (nonostante il fisico molto poco tonico) e dove fu infine ammesso solo come "Bodydonna-in-prova". Alle Survivor Series, venne buttato fuori dal gruppo perché la sua forma fisica non era abbastanza buona. Spicolli ottenne scarso successo con l'identità di Radford, vincendo raramente.

Nel 1996 venne trovato senza conoscenza da un vicino di casa dopo che era collassato sul divano a causa di un'overdose di medicinali. Restò in ospedale per diversi giorni prima di essere dimesso. La WWF, all'epoca nel mezzo degli strascichi dovuti allo scandalo steroidi di due anni prima, lo licenziò con la clausola che non andasse a lavorare nella federazione rivale WCW prima di un anno.

Circuito indipendente

Extreme Championship Wrestling

World Championship Wrestling

Morte
Mucciolo aveva smesso di assumere droghe dopo le rinnovate paure circa il suo stato di salute, ma la notizia improvvisa della madre malata terminale di cancro lo fece ricadere nel vizio. Il 15 febbraio 1998, morì di overdose di alcol e droga all'età di 27 anni, soffocato dal proprio vomito nel sonno. Gli investigatori rinvennero in loco una fiala vuota di testosterone, pillole antidolorifiche, e psicofarmaci anti-ansia. Il coroner della contea di Los Angeles determinò che le droghe avevano potuto contribuire al cedimento del cuore.

Personaggio
Mossa finale
 Spicolli Driver (Death Valley driver)

Mosse caratteristiche
 Cutter
 Northern Lights suplex
 Powerbomb
 Spinning spinebuster

Musica d'ingresso
 Louie, Louie dei The Kingsmen

Titoli e riconoscimenti
AWF
 AWF Heavyweight Champion (1)
Interwest Wrestling Federation
IWF Heavyweight Champion (1)
World Wrestling Association
WWA World Trios Champion - con Bill Anderson (1) e Tim Patterson (1)

Note

Altri progetti

Collegamenti esterni

Morti per overdose
Sportivi italoamericani

redpajama_set_name: RedPajamaWikipedia


text:
Electronic Law Journals Journal of Information Law & Technology
Kelman (3)
About JILT
JILT Team
BILETA2010
Submission Standards
JILT 1998 (2) - Alistair Kelman (3)
Michael F. Flint's
A User's Guide to Copyright (4th Edition)
Butterworths, 1997, £40
450pp, ISBN: 0-406-04608-5
Alistair Kelman
LSE Computer Security Research Centre
akelman@cix.compulink.co.uk
As an exercise I dug out my well thumbed copy of the first edition of this book on copyright (where I found that I had left in an old computer punch card from one of my early programs as a bookmark). The first edition was 226 pages (including the index). The latest edition is double the size at 450 pages. But sadly the increase in size has not led to an increase in quality.
My first edition gave clear and sensible professional guidance through the 1956 Copyright Act. It was the first textbook on this topic to use tables to illustrate the incidents of copyright. The new edition continues this tradition. But unfortunately the complexity of modern copyright law and regulation is such that the tables no longer help comprehension. If they were to continue to be illustrated on paper they would have to become network diagrams of fiendish complexity - the kinds of interdependency diagrams which turn up in presentations on European projects which nobody understands but which the Commission seems to insist are part and parcel of their reviewing process.
Reading through the table on page 59 explaining how the new Term Directive is to be applied - which extends the copyright term in the European Union for most works from the life of the author plus fifty years to the life of the author plus seventy years - I felt that the analysis really called for a flowchart rather than a table. A few moment further thought caused me to conclude that the ideal solution would be a small program, maybe written in Java, which would illustrate the rules for the determination of the copyright term. Ask a few questions and get the answer. Let the book speak back to you.
The main weakness in the new edition is that it fails to be either a comprehensive reference work or a good introductory guide. Although it makes some mention of competition law the European cases its cites no longer represent the modern law - European competition law has moved on since Deutsche Grammophone GmbH and Metro was reported in 1971 - we now have something called the Single Market. Although the book was finished in April of last year it only contained a few scant references to the TRIPS agreement and the Geneva WIPO meetings of December 1996 which move copyright into new areas. Trying to keep the length down has naturally led to a lack of explaining the technology to the reader and putting matters into context. But this does not make it digestible.
Yet it would be wrong to dismiss the book. As a first port of call for seeking information on a copyright topic it is very useful. It is not an easy read - but this is mainly because the subject matter is highly complex. It is very weak on European Law, multimedia and electronic publishing - which happen to be the new chapters added in this edition. But as a text to be read alongside Directives and statutes the book continues to be reasonably useful.
I would like to see the next edition of A User's Guide to Copyright abandon print as its main medium and become a multimedia work with interactive tables, hyperlinks and worked examples. Only then could it regain the clarity and utility of the first edition.
This is a Book Review published on 30 June 1998.
Citation: Kelman A, 'Michael F. Flint's, A User's Guide to Copyright (4th Edition)', Book Review, 1998 (2) The Journal of Information, Law and Technology (JILT). <http://elj.warwick.ac.uk/jilt/bookrev/98_2kelm/>. New citation as at 1/1/04: <http://www2.warwick.ac.uk/fac/soc/law/elj/jilt/1998_2/kelman3/>.
Email: law at warwick dot ac dot uk
School of Law, University of Warwick, Coventry CV4 7AL, United Kingdom
Page contact: Abdulhusein Paliwala
Last revised: Wed 23 Feb 2005


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Leather reclining corner sofa as your reference » Today sofas come in literally a huge selection of styles with never-ending selections of upholstery. You can order your couch mail order through companies like Pottery Barn and Crate and Barrel. A lot of people will tell you that after style the most crucial thing they look for in a couch is comfort. Deciding on the best style of couch to enhance your property is key. There are many different styles of sofa to choose from, but most manufacturers break them down into two unique styles, traditional and fashionable. Leather Reclining Corner Sofa is For example, more traditional varieties of couch would include barrel again, British arm, tufted again, tight again and tuxedo.
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Leather reclining corner sofa as your reference » However, depending on cloth choices a Tuxedo couch could be used in a contemporary home. Modern day styles include sock arm, route back again and sectional. Some sofas include pillows attached to the couch, some come with loose pillows that you can free style any way you choose. Leather Reclining Corner Sofa One more thing that gives your sofa an absolute style is fabric choice. After you visit most furniture stores you should have the capability to first choose the style couch you want and then decide on the selection of cloth. Some manufacturers have 30 or more different fabric you can choose from if you are designing a sofa, with the sole limit being how much money you want to invest. The decision of fabric can add thousands of dollars to the final cost of a couch. Bold bright colors and geometric designs would be utilized on modern sofas and softer muted colors and designs would be utilized on traditional sofas.
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Leather reclining corner sofa as your reference » Leather sofas are incredibly popular. Leather Reclining Corner Sofa with tedious treatment leather is an extremely durable upholstery choice on the sofa. You'll want to keep a leather clean and moisturized.
Another couch option you will want to consider is whether you will want sofa bed, also called a sleeper couch, or a reclining sofa or a convertible sofa. Naturally a sleeper couch or convertible couch can come in very convenient as an extra bedroom for a person who may are in a flat or have a smaller home who still wishes to be able to accommodate guests instantaneously.
Leather reclining corner sofa as your reference Much like any major purchase, check around. Look around online at different sofa selections to be able to get an idea of what you want before you visit store after store after store. If you see a couch doing an online search you ought to be able to find a store that markets that one brand.
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When we think of gentle giants there are many animals that come to mind, but to me it's my son's mastiff Piper. She was found roaming the streets living on scraps, and weighed in at around 88 pounds. When he saw her he was walking by a store and all of a sudden he was so intrigued he had to stop and ask what she was. He was told she was a mastiff up for adoption and as they say, the rest was history.
She weighed in at around 150 pounds and was the gentlest, sweetest creature you've ever seen, despite her time on the street. She loved egg nog, loved sunning herself in my son's back yard, and when the vet finally said her time had come due to an inoperable tumor, she still surprised everyone by living eight months longer than planned. She loved my son and my granddaughter and would welcome anyone who came in her home; she simply wasn't ready to go yet, she had more loving left to do.


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The Rules of Business are being Re-Written, will you be erased?
Article written by Craig Wing for the Webmagazine Octave.
Craig is a partner of FutureWorld international, assisting companies future-proof themselves and create their future and culture to survive the emergent world of technology, customer changes and "New World or Work."He has a BSc (Eng), MSc and MBA, started 4 companies has 2 provisional patents and helped over 1,000 entrepreneurs. At Google, he launched Woza online where SME's created 50,000 websites: one every 10 minutes. He is a Desmond Tutu Fellow, WEF Global Shaper, Destiny Man Top 40 under 40, TEDx speaker and profiled at the Clinton Global Initiative. He is the youngest graduation speaker at the University of Johannesburg, South Africa.
Have you considered why? These origins stem from the agrarian days when work started at dawn, you toiled the fields, took a lunch break when it was the hottest then continued until sunset when you herded the animals back and traversed home. As for the siesta: it's typically to avoid the hottest time of the day in regions where the sun sets later hence suspending work till it becomes cooler.
This outdated perspective is even more pronounced in a future full of self-driving cars, artificial intelligence, virtual workforce, gig economy, and decentralized and distributed work. While the world (primarily driven by the Internet) has changed, the rules of business have not.
Further we would perceive Millenials as bereft of loyalty. Millenials are not disloyal; the same companies expected their parents to work for years, sacrifice time, blood sweat and tears then be fired at the whim of a senior executive seeking to extend shareholder value. If the company isn't loyal to them, why should they be loyal to it?
To keep, and attract, the best possible millennial, employers can't focus on just the role or a higher paying salary, but rather on company culture. This is inexplicably linked to the vision and the corresponding values. This vision isn't about profit or shareholder value; rather it's a dream that aids society and excites and energizes employees to get up each morning. The authentic values are the ones that you'll hire and fire by, not those in reception areas and shareholders documents. If you create this vision and culture to align with your strategy–one beyond profit–millennials will happily take a pay cut, and work longer hours to be part of a greater cause. For them, there is no such thing as a work/life balance: Work and life are interchangeable and the same.
With this in place, you should then focus on the internal processes to remove hierarchy and bureaucracy to realize improved results and efficiencies. The companies that win will be those that embrace speed as the new currency supplemented by the ability to put people decisions over process. This is beyond "lean" or "agile" and fundamentally rewrites the DNA of the company to be entrepreneurial, innovative and risk accepting. This same philosophy needs to extend into the hiring process and resonate the same ethos with vendors, partners and your ecosystem.
Only once we have achieved this can we talk about technology. Artificial intelligence will eradicate entire industries. Today they can do the jobs of 30,000 lawyers, diagnose disease at a higher accuracy rate and replace entire call centers. Those careers with a high level of specialization are most at risk of AI disruption–the same skills of the "vertical of the T" further justifying the need for T-shaped individuals.
Beyond AI, robotics will replace physical workers, augmented/virtual reality render physical proximity obsolete, and self-driving cars and gig economy workers enhance a virtual workforce.
What is the imperative of leadership in a world shaped by these gargantuan earthquakes? We cannot escape the march of technology: we must embrace it. Use technology to make us more human, to supplement our humanness: creativity, relationships, empathy, passion and emotion. To be relevant in the future, we must embrace our very humanness while using technology as a tool.
The rules are being fundamentally rewritten with a new kind of employee, the need to align your culture and strategy and unleash your humanness through technology. Only then can you start the journey to drive a new business beyond profit. Not only are the rules of business being rewritten, but the very reasons for business are.


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Samsung offers a brilliant range of fridge-freezer solutions suitable for all budgets, ensuring you'll be able to find a model which fits your specific needs.
These space-saving units have become very popular for a number of reasons; for instance, they offer a good balance between fridge and freezer space, with several available splits (such as 50/50, 60/40 and 70/30). This enables consumers greater choice and the ability to get the most appropriate product based on their requirements.
First you should always carefully measure the available space which you have for your fridge freezer, as getting this wrong can cause tremendous hassle. You should also ensure that the fridge freezer will be large enough to fit your household's needs, as getting a model which is too small will cause problems and getting a model which is too large will be more expensive to operate.
It's also important to remember that the typical running costs of fridge-freezers will vary depending on the manufacturer, so always ask about this before you purchase a model.


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Justia Patents Stephen R. Quake Inventions, Patents and Patent Applications
Patents by Inventor Stephen R. Quake
Stephen R. Quake has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
SIMULTANEOUS SINGLE-MOLECULE EPIGENETIC IMAGING OF DNA METHYLATION AND HYDROXYMETHYLATION
Abstract: Provided herein is a method for analyzing genomic DNA In some embodiments, the method may comprise labeling a genomic sample by adding a capture tag to the ends of the DNA molecules in the sample and labeling molecules that comprise hydroxymethylcytosine with a first fluorophore, immobilizing the labeled DNA molecules on a support, and imaging individual molecules of hydroxymethylated genomic DNA on the support.
Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Inventors: Chunxiao Song, Stephen R. Quake, Axel Brunger, Jiajie Diao
NON-INVASIVE DIAGNOSIS OF GRAFT REJECTION IN ORGAN TRANSPLANT PATIENTS
Abstract: The invention provides methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a transplant.
Inventors: Stephen R. Quake, Thomas M. Snyder, Hannah Valantine
METHODS AND SYSTEMS FOR DETERMINING A PREGNANCY-RELATED STATE OF A SUBJECT
Abstract: The present disclosure provides methods and systems directed to cell-free identification and/or monitoring of pregnancy-related states. A method for identifying or monitoring a presence or susceptibility of a pregnancy-related state of a subject may comprise assaying a cell-free biological sample derived from said subject to detect a set of biomarkers, and analyzing the set of biomarkers with an algorithm to determine the presence or susceptibility of the pregnancy-related state.
Inventors: Lian Chye Winston Koh, Stephen R. Quake, Hei-Mun Christina Fan, Wenying Pan
Allergen-specific antibodies
Abstract: In one aspect, methods of generating human monoclonal antibodies that specifically binds to an allergen are provided. In some embodiments, the monoclonal antibodies are generated from sequences identified from isolated single B cells from a human subject who is allergic to the allergen.
Assignees: Chan Zuckerberg Biohub, Inc., The Board of Trustees of the Leland Stanford Junior University
Inventors: Derek Croote, Stephen R. Quake, Kari Nadeau, Spyros Darmanis, David N. Cornfield
Cell-free nucleic acids for the analysis of the human microbiome and components thereof
Abstract: Methods, devices, compositions and kits are provided for analysis of the microbiome or individual components thereof in an individual. The methods find use in a determination of infection, in analysis of the microbiome structure, in determining the immunocompetence of an individual, and the like. In some embodiments of the invention, the individual is treated with an therapeutic regimen, e.g. drugs, diet, radiation therapy, and the like.
Assignee: The Board of Trustees of the Leland Stanford Junior University
Inventors: Iwijn de Vlaminck, Michael Kertesz, Kiran Kaur Khush, Mark Alec Kowarsky, Lance Martin, Stephen R. Quake, Hannah Valantine
Date of Patent: August 2, 2022
METHODS FOR PROFILING AND QUANTITATING CELL-FREE RNA
Abstract: The invention generally relates to methods for assessing the health of a tissue by characterizing circulating nucleic acids in a biological sample. According to certain embodiments, methods for assessing the health of a tissue include the steps of detecting a sample level of RNA in a biological sample, comparing the sample level of RNA to a reference level of RNA specific to the tissue, determining whether a difference exists between the sample level and the reference level, and characterizing the tissue as abnormal if a difference is detected.
Publication date: July 7, 2022
Cell-free nucleic acids for the analysis of the human microbiome associated with respiratory infection
Implantable Micro-Fluidic Device for Monitoring of Intra-Ocular Pressure
Abstract: Glaucoma is the second most common cause of blindness in the global world. It is a multifactorial disease with several risk factors, of which intraocular pressure (IOP) is the most important. IOP measurements are used for glaucoma diagnosis and patient monitoring. IOP has wide diurnal fluctuation, and is dependent on body posture, so the occasional measurements done by the eye care expert in clinic can be misleading. We provide an implantable sensor, based on microfluidic principles, which in one example has 1 mmHg limit of detection, high sensitivity and excellent reproducibility. This sensor has an optical interface, which enables IOP to be read with, for example, a cell phone camera. The design, fabrication, along with the option of self-monitoring are promising steps toward better patient care and treatment for this devastating disease.
Inventors: Yosef Mandel, Ismail Emre Araci, Stephen R. Quake
SYSTEM FOR DETERMINING A HEALTH STATUS OF A TISSUE OF INTEREST
METHODS AND COMPOSITIONS INVOLVING THERMOSTABLE CAS9 PROTEIN VARIANTS
Abstract: The disclosure provides Cas9 protein variants that are thermostable at elevated temperatures (e.g., at least 70° C. or above). A Cas9 protein may have at least 75% sequence identity to a wild-type Cas9 protein (e.g., a wild-type Cas9 protein having the sequence of SEQ ID NO:1) and/or one or more amino acid substitutions relative to the wild-type Cas9 protein.
Inventors: Stephen R. Quake, Stephanie Tzouanas Schmidt, Feiqiao Brian Yu, Paul Blainey, Andrew Paul May
IDENTIFYING HUMAN B CELLS EXPRESSING ANTI‐ALLERGEN ANTIBODIES


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1024 @onethousandtwentyfour@weirder.earth
DEBILITATION: Loud women are unlovable.
REHABILITATION: Loud women are unlovable unless they work it for Insta.
DEBILITATION: I don't listen to P.O.C.
REHABILITATION: I don't listen to P.O.C. unless they're active on Twitter.
DEBILITATION: Trans women aren't women.
REHABILITATION: Trans women aren't women unless they're visible and invest in normative medical systems and gender establishments.
Something I'm learning to pay more attention to (thanks to Puar) is the way in which DEBILITATION/REHABILITATION work together to extract labour from populations
first debilitating a population, then demanding labour from them in order to be rehabilitated
and I think contemporary social media in late capitalism is a prime example of this.
So many people—especially queer people, POC, disabled folx, the poor—give free labour to social media (and its cousin, the dating app) in exchange for love and material resources (BOTH IMPORTANT) which abled straight white folks are granted by birthright. Capitalism takes these things from us, and then says « hey yo, if you work for this you can get some of it back ».
I don't use DEBILITY lightly—we're all depressed; we all lack medical care.
It's zero secret that Twitter, Vine, Insta were built on the backs of P.O.C. labour. It's zero secret that Masto was built on the backs of queer labour. I'm not talking devving, I'm talking our participation in this space.
That LABOUR was predicated on the lack (or disenfranchisement) of communities and networks locally, on our being deprived normative systems of love and support, directing us into sites of labour where our WORK to find and speak to each other can be captured and commodified.
This is the primary difference between queer public performance NOW (taking place on social media, YouTube, etc) and queer public performance taking place in the bars and secret places of the 80s and 90s. THAT performance was resistance IN SPITE of a normative, disciplinary system. Modern queer performance has been modulated to instead FUND and SUPPORT that very system, through controlled, "voluntary" labour in approved, capitalizable locations.
May 08, 2019, 09:05 · Toot! · 0 · 6 · 14
Don't be content with this shit!! Don't be content with just having communities in these approved, exploitable spaces. Fuck, we need them, but at the same time we gotta work to build our OWN shit outside of them. Build communities in places where there ain't supposed to be communities. Bring queerness to places where there ain't supposed to be queerness. THIS IS LABOUR TOO. Watch yourself, they want you to burn out.
Live life in places where you ain't supposed to be alive. I don't mean survive. I mean LIVE LIFE. Bring life. We have a shortage y'all. Help a comrade out.
I don't just push the arts for laughs, friends.
(quote leftie) @copyleftie@cybre.space
@onethousandtwentyfour i know you don't get boost notifs (unless you've changed that lately but i doubt it) but it was very weird seeing this last part of the thread being boosted out of context
@onethousandtwentyfour i feel like rage against the machine probably isn't your thing but if you've ever heard Killing In The Name, the climax of that song but out of context is kind of an exaggerated version of what seeing that boost happen felt like
@copyleftie wait which part of this song is supposed to be the climax
@onethousandtwentyfour lolllll
did you finish it yet though
cause if you haven't i think you'll figure out what part i was talking about once it happens
@copyleftie no i heard the whole song and it was all at like the same volume and tempo pretty much the entire time
was it the fuck you part?? i'm only guessing this because it came at the end and included the words "fuck you"
@onethousandtwentyfour yes that part
@copyleftie ngl i was expecting something more like https://youtu.be/lhp2ySUGXO0
@copyleftie i'm not judging you for your musical tastes btw
@onethousandtwentyfour well what i was getting at is that seeing that post alone get boosted feels kind of like if you listened to Zack de la Rocha shouting "fuck you I won't do what you tell me" repeatedly but without hearing the parts about policing as an extension of white supremecy before it
@copyleftie honestly if more people phrased "fuck you" as "i'm going to bring life" i would be a lot happier about the state of activism on the fediverse, even without the theoretical underpinnings which preceded it
@copyleftie like i don't care if we have an arts scene for the Right Reasons if we can just get an arts scene going for once lmao
aschmitz @aschmitz@lardbucket.org
long, queer disability and social media
@onethousandtwentyfour I'm curious about this particular line of thought in a few ways:
1. Do you think all of "them" do this on purpose? For example, I don't have many POC readily available in my daily life in person. I listen to the ones who are, but it's low single digits and a biased sample. Beyond that, sure, I only listen to the ones active online because that's the other place I'd see them. (Not Twitter, because I'm not there, but still.) Are there better alternatives? Obviously they don't owe me anything, and I don't feel it's reasonable for me to pester people who are just doing their own thing, although I'd be happy to hear from them.
queer disability and social media
@onethousandtwentyfour 2. We're sitting here in the fediverse. This might be an "acceptable" space to some privileged people, as it's less popular and so on, but it's not a particularly capitalizable space. Is it a specific exception to what you were saying, or are the tide pools and eddys of society generally able to support marginalized people interacting in a slightly less disabled state?
@onethousandtwentyfour (I recognize that neither of these is 100% true: I will happily listen to stories from POC even if they weren't originally online, for example, and some people are making money and occasionally a living out of fediverse work, but both of those are exceptions rather than common cases.)
@aschmitz regarding (1), this is kind of my point, and the "I" in my original toots was intended to be systemic not personal. Our culture does not give P.O.C. platforms on which to speak generally, which forces them into commodified spaces to be heard. For listening anyway, I think that some spaces are better than others regarding this (books, journalism, indie music, all very good even if there is some exchange of capital) where as others are more suspect.
@aschmitz regarding (2), the fact that nobody makes money off of mastodon doesn't mean that there isn't labour exploitation OR that the system as a whole doesn't "profit" (in a growth/power sense) from the fact that people don't have any other options. i think that's a dangerous situation because in a way it's making the success of mastodon dependent on this continued lack in other communities.
@aschmitz I think ideally mastodon would focus on ways to build, integrate with, and serve communities in other spaces instead of trying to act as a surrogate for them. that means measuring "success" not in growth/users/posts but in the strength and versatility of the resulting community.
@aschmitz right now i think social media has a tendency to actively make communities weaker because community drama fuels social media growth and that's bad.
in contrast, a social media in a facilitator role is okay with (and actively wants to create) a situation where it is not used all the time because there are other options. this is not the mentality of modern social media right now.
@onethousandtwentyfour Can you expand on what that facilitator role would look like? It seems like you're saying it should create competitors for itself, which doesn't seem to serve any real purpose other than having alternatives. (Which is fine, but not a *goal* as far as I can tell.) Or is this a "you should integrate with other existing things where existing communities are"? (The main problem here is that most - though not all - other things seem to be hostile to integrations they don't control, and I'm not sure how, say, Mastodon could work around that other than having open and documented protocols for integration, which is about 50/50 on.)
@aschmitz my recent posts kind of hint at this but i think a big part (or at least, starting place) is allowing for finer subcommunity distinctions within mastodon and also increasing the versatility of posts, what they can look like, and how they can be used. and this is entirely a critique of Mastodon's implementation and not ActivityPub as a protocol because ActivityPub i think is designed fairly well for this sort of thing.
@aschmitz and i think if you compare mastodon and current AP implementations with some of the hypotheticals that have been proposed you can kind of see the difference there.
it's not so much that Mastodon should/shouldn't encourage competition so much as competition shouldn't be *relevant* because the focus isn't on growth but on strength of services and strength of community.
Satsuma 🃁 @Satsuma@wandering.shop
@onethousandtwentyfour @aschmitz practically, this basically means prioritizing being self sustaining over growth, right?
Like with dreamwidth, for example, the goal was essentially to meet a specific communities needs long term, so all the features of dw reflect that communities needs, but make dw a terrible "generic" platform. The whole point is that it's NOT for everyone. I'm not on it but I believe Metafilter has a similar model also
@Satsuma @aschmitz mm, i think i disagree with even prioritizing being self‑sustaining
if something better than masto comes along, that's a good thing, and masto should facilitate the transition to the new system rather than oppose it in self‑interest imo
@onethousandtwentyfour @aschmitz hm yeah thats fair
@onethousandtwentyfour @Satsuma That doesn't seem to be a good way to critique anything that's currently "best", right? Like, maybe Mastodon would! At the very least, I can imagine a lot of server operators would. But as far as we know, it hasn't happened yet, so we can't yet know. Yes, migration paths are good. The existing APIs aren't bad (Salmon keys are the only thing I know aren't accessible), but a better migration path depends on a thing to migrate *to*.
@aschmitz @onethousandtwentyfour currently you cant even migrate your account between mastodon servers, let alone different activitypub implementations?
@Satsuma @onethousandtwentyfour That's... maybe a problem? You can export and import followed users, which is about as good as APub will get at the moment, but it's a fair point that there's room for improvement. My question is more whether it's worth creating a new protocol to solve that (*relatively* rare, although I'm sure it comes up daily) issue, or whether we still have more notes to take on what to improve before moving on.
@aschmitz @onethousandtwentyfour wait take notes before moving on to what?
We can just, change activity pub to add migration? I dont think anyone here is advocating for ditching activitypub entirely
@Satsuma I think @onethousandtwentyfour is advocating a migration path from Mastodon to The Next Thing, and I'm not sure The Next Thing is a real thing yet, or honestly worth building just yet. Sure, I'm fine tweaking things (or building something else, if there's a good reason!).
(Migration would be a massive change though. It "exists" in Mastodon, and accounts get flagged that way, but handling the follower relationships moving would require a lot of new authorization logic that APub quietly avoids ever defining. For similar reasons, you can't fetch followers-only posts from history, although there might also be good policy reasons for that.)
@aschmitz @onethousandtwentyfour i took that very much in the context of migrating from mastodon to other, better activitypub implementations, not throwing the whole protocol out the window
Also building a migration path between currently existing activitypub servers would definitely make it easier to build a migration path to *non* activitypub servers, so it's still a benefit either way?
@Satsuma @aschmitz i'm not advocating one way or the other (i'm rather impartial on Where The Fediverse Should Be Headed since i'm not involved in development anymore), but i'm saying that an emphasis on self-preservation *isn't* impartial, and is in fact explicitly advocating *against* change. while that might not cause problems for us now, it will in the future (when/if such alternatives emerge, and almost certainly during the course of their development)
@Satsuma @onethousandtwentyfour And yes, I'm not arguing against a way to migrate accounts. I badly *want* APub to have an authentication mechanism for things like that, and Salmon is like 90% of the way there, just not *officially* documented directly in APub (although most things use it, I think?), so it's not a huge stretch.
(I don't love Salmon, but it's already implemented here, which is an advantage.)
@aschmitz @Satsuma to the contrary, i think the best services will always have an eye to the future and be trying to pave the way for something better :P
Mastodon was a hacked-together proof-of-concept largely developed in one person's spare time that just happened to get popular, and the idea that we should keep funneling our energy into that perpetually is actively keeping us from replacing it with something nicer and designed with the knowledge we have now
@onethousandtwentyfour @Satsuma Is it? I mean, sure, we could rewrite everything now just for kicks, or we can find a local maximum from what exists. Are we done learning lessons from Mastodon to the point where we should just pour energy into the next thing?
(From my perspective, being ready for the next thing mostly involves a data model that isn't terrible, and developers who are willing to adapt. Trying to predict the next thing in detail seems impossible.)
@onethousandtwentyfour @aschmitz as opposed to like, with Mastodon Gargron has specifically consistently stated that the goal is to replace twitter, which means it needs to be designed for literally everyone who's currently on twitter, which is a goal thats only possible by prioritizing getting new users over optimizing for the current community. Because the more optimized it is, the more niche it is & the less broad appeal it will have


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Protein Discovery Could Help Prevent Type 2 Diabetes
Published February 22, 2008 | Updated January 20, 2016
DURHAM, N.C. – Before people develop type 2 diabetes, cells in the pancreas spend years churning out increasing amounts of insulin, the body's key player in maintaining normal blood sugar levels. The constant stress of creating more and more insulin eventually exhausts these cells, and they quit working – one of the hallmarks of the disease.
Duke University Medical Center researchers have shown that they can control insulin release in the pancreas by blocking a protein called Gáz (G-alpha-z). In mice, deleting the protein from cells that make insulin, called beta cells, improves their blood sugar control.
Mice missing the protein produced more insulin and cleared sugar from their bloodstreams faster than normal mice, the researchers found. This means mice without Gáz would process blood sugar, or glucose, more quickly and efficiently than normal mice after eating sweets, for example.
"A drug that targets the Gáz protein could slow or even prevent the onset of type 2 diabetes by improving how beta cells respond to glucose," said Michelle Kimple, Ph.D., a biochemist at Duke University Medical Center.
The study appears in the Feb. 22, 2008 issue of The Journal of Biological Chemistry. The research was funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Institute of General Medical Sciences.
About 90 percent of diabetics, or 221 million people worldwide, have type 2 diabetes, according to the International Diabetes Foundation. The disease has two distinct but related causes: 1) beta cells don't make enough insulin in response to rising blood sugar; and 2) tissues throughout the body are resistant to insulin, the hormone that helps cells use glucose for food, so it takes more insulin to make the same amount of energy.
The Duke researchers investigated the Gáz protein via a mouse that does not have the genetic code for making the protein in any of its cells. Compared to normal mice, the genetically-altered mice (called knockout mice) had the same levels of blood glucose and insulin both when fed and during fasting. They weighed about the same and their pancreatic cells were similar in size and structure. The knockouts also didn't show any negative effects on other parts of the body, nor did the mice develop diabetes.
But a big difference appeared when the two sets of mice were given a large dose of glucose. The altered mice produced more insulin and cleared sugar from their bloodstreams significantly faster than normal mice.
"In the knockout mice, the glucose concentration in blood goes down faster and doesn't peak as high, which suggests that they were secreting more insulin," said Kimple, lead study author and a research scientist in the laboratory of Patrick Casey, Ph.D., James B. Duke professor of pharmacology and cancer biology.
Further experiments in laboratory cell cultures revealed the knockout mice beta cells only made extra insulin when faced with a big increase in glucose. It turns out that removing the protein interferes with the cell signals that control insulin production in response to glucose.
"You don't have increased insulin secretion unless there is a higher glucose load. And you don't want to have increase insulin secretion all the time, because that could lead to insulin resistance," Kimple said.
She said a Gáz-targeted drug could treat a diabetic's dysfunctional beta cells by changing how the cells manufacture and release insulin in response to glucose, reviving tired cells or preventing them from wearing out in the first place.
There is already evidence that a drug targeting the pathway that the Gáz protein inhibits could be a therapy for type 2 diabetes, Kimple explains. The Food and Drug Administration has approved a diabetes medication, called Byetta, that activates certain chemical signals in beta cells, leading to more insulin.
Kimple and her colleagues have received a grant from the NIDDK to further test whether removing Gáz protein will protect against developing type 2 diabetes. They plan to feed the altered mice a high-fat diet, based on what the average American eats, and monitor how many develop diabetes. "This is the necessary next step in showing that this might be a potential drug target," Kimple said.
Collaborators on the study include Candice Bailey, Patrick Fueger, Christopher Newgard and Patrick Casey, all of Duke; Jamie Joseph of the University of Waterloo in Ontario, Canada; and Ian Hendry of Australian National University in Canberra, Australia.
Previous Life Flight makes Johnston helicopter service permanent
Next Ten Year Trends in Heart Failure


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HomeFunds & awardsAwardsKNAW Beijerinck Prizes for Virology
KNAW Beijerinck Virology Prize
The Royal Netherlands Academy of Arts and Sciences awards the Beijerinck Virology Prize every two years to an internationally renowned researcher.
The M.W. Beijerinck Virology Fund was founded in 1965 by Dr and Mrs L.E. den Dooren de Jong in memory of Martinus Willem Beijerinck (1851-1931), one of the founders of virology.
The biennial prize was established in 1965 and consists of a medal engraved with the image of M.W. Beijerinck and a monetary award of EUR 35,000.
The Beijerinck Virology Prize is awarded to a researcher who has distinguished himself or herself internationally in the field of virology, including its biochemical and biophysical aspects.
Nomination and award ceremony
The following round of nominations will begin in June 2020.
Dianne van Avendonk
Extension regulation
Academy Extension Arrangement (PDF)
Training programmes covered by the extension arrangement (PDF)
Ouderverklaring extensieregeling KNAW (in Dutch) (DOC)


They are 'hidden heroes' who bravely face autism and all the overwhelming challenges and huge responsibilities that accompany it.
A shopping trip to the supermarket. A simple meal at a fast food restaurant. A good time at the movies. For most people, these are simple, ordinary and enjoyable activities. But for many special needs parents, participating in these everyday events can be stressful and overwhelming.


New MAC member, Nick Gant returned to his home town to participate in the Lincoln 10k. The primary objective was to delay his grandmother's weekly visit to Tesco caused by the road closures around her house. Every year she complains about missing out on the reduced 10p breadloaves and flacid courgettes due to the hoardes of joggers blocking the roads. Unfortunately her grandson's initial plan was thwarted when got carried away with the enthusiasm of the crowd and crossed the finish line in he shadow of the country's finest gothic cathedral with a time of 40:00 in 190th position (38th in the M40 category).


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<readable><title>482830610_13a0a6c924</title><content>
A girl reads and listens to music on a bus .
a woman reads a book on a train .
A woman reads while on public transportation .
The girl is sitting on a train and reading a book .
Woman on a train , reading and listening to headphones .
</content></readable>

redpajama_set_name: RedPajamaGithub