text:
Home Iowa Drivers License & ID More Common Tasks >> (License) Organ Donation
Organ Donation in Iowa
You Could Be a Hero
Register as an Organ Donor in
When you sign up to be an organ donor, you change lives for the better—plus, it's fast and easy!
Free online registration
95% of Americans support organ donation
One donor can save up to 8 lives
Become an Organ Donor Today
Thank You for Being a Hero!
You've just saved up to 8 lives—thank you! Please check your inbox for an e-mail confirmation.
The Iowa Donor Network (IDN) is the nonprofit organization in charge of organ, tissue, and eye donation for the state of Iowa. The Iowa Department of Transportation is a partner of the Iowa donor network and helps with organ donation registration.
In Iowa, there are currently 24 people on the waiting list for a heart, 485 people waiting for a kidney, and 40 people waiting for a liver.
Any Iowa resident can be considered for organ donation. There are no age requirements and no costs associated with the procedure.
Register as an Organ Donor
NOTE: If you are at least 18 years old, you may register with the Iowa Donor Network. With written permission, and in certain cases, a consent form from a parent or guardian, anyone 17 years old or younger can also register with the Iowa Donor Network.
You can register online or in person at your local IA DOT office.
To register, you can:
Sign up on the Iowa Donor Network website and fill out the required information.
Register through ORGANIZE.org, a national registry database that allows your registration to follow you from state to state.
You will not need a driver's license or other ID, but you must include date of birth, e-mail, address, and other pertinent information.
When you apply for your Iowa driver's license at your local Iowa Department of Transportation office, you will be asked if you would like to register as an organ donor. If you check "yes" on your Iowa driver's license application form, you've given legal consent to donate your organs after your death.
To get the organ donor information on your license, you will need to apply for an updated license.
NOTE: If you wish to also donate your corneas and tissue or allow your organs to be used in medical research, you must be listed on the Iowa Donor Registry as well.
Important Details About Organ Donation
There are absolutely no fees associated with organ donations, as the Organ Procurement Organization (OPO) covers all related costs.
In order for the OPO to utilize and pass on your organs, you must have died from an automobile accident, stroke, aneurysm, or other irreparable neurological injury. Moreover, blood and oxygen must continue to flow to the organs until they can be recovered. Further, only after all efforts have been taken to save the patient's life can donation be a possibility. The state donor registry than looks through the donor database and must obtain consent from a relative, spouse, or other authorized representative. The national transplant waiting list is then searched to determine a suitable candidate.
While your medical history will affect how many of your organs are usable, it will not automatically bar you from being considered for organ donation. For example, many cancer patients can still be approved as donors.
Donated organs are distributed to transplant recipients based on factors such as length of time on the waiting list, blood type, geographical location, and severity of illness. Criteria such as income, age, gender, or race are never considered.
Update/Change Your Organ Donation Status
You update your registry information by logging into the Iowa Donor Network website and update any information you wish including your address and the type of organs you are willing to donate. You can also update it through ORGANIZE.org.
You have the option, too, of visiting an IA DOT office to update your information there.
How You Can Help With Organ Donation
Instead of waiting until you pass to help those in need, there are other ways to support people on organ transplant waiting lists. You can:
Become a living donor in which you are able to donate an organ or part of an organ to a recipient. Living donors can donate a portion of the pancreas, a lobe of a single lung, or a segment of the liver.
Make a monetary contribution: The Iowa Donor Network also accepts monetary donations by individuals who want to support the cause. Donating in this way can help the registry continue operations and help with saving lives.
Purchase Organ and Tissue Donor Awareness license plates to spread awareness of the program. Choose from numbered plates or personalized plates and complete the Organ and Tissue Donor Awareness License Plate Application to receive your awareness plates.
Organ Donation Myths
While organ donation rates have increased slightly in recent years, there are still many misconceptions about the process. A common organ donation myths is that some people can't donate because of their religious beliefs. Roman Catholicism, Islam, Buddhism, Judaism, Protestantism, and all other major religions now support organ donation.
For more information about other misconceptions with organ donation, please visit our page about Organ Donation Myths.
Replacing a Lost License
Other Licenses & Endorsements
Driving Record
How Organ Donation Works
Organ Donation Facts
How Organ Recipients Are Chosen
Kidney Transplants and Organ Donation
Liver Transplants and Organ Donation
Corneal Transplants and Organ Donation
Ways to Get Involved with Organ Donation
Organ Donation Quiz
Looking for Organ Donation in another state?


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Decatur Development Authority Passes $1.2 Million Budget for 2020
Business Decatur Editor's Pick Trending
Decaturish.com Aug 13, 2019
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Decatur City Hall.
By Cathi Harris, contributor
The Decatur Downtown Development Authority passed its budget for the 2020 fiscal year at its regular meeting Friday morning.
The budget projects total expenditures of $1.24 million with a predicted total revenue of $1.25 million.
The majority of the DDA's revenue, an anticipated $750,000 comes from an allocated percentage of the city's property tax digest. The authority gets 0.38 mills of the total collected by the city.
Decatur property owners will notice the specific allocation as a line on their annual property tax statements. The city collects the money on behalf of the DDA and deposits the funds into the authority accounts.
"That is the bulk of the funding that the DDA receives, and we have some property that we own and management contracts for some properties that also provide an income," Assistant City Manager Lyn Menne said after the meeting.
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To see the full DDA budget, click here.
The development authority was formed by an act of the state legislature for the purpose of planning, organizing and financing projects in the city's commercial business districts. To do so, they often purchase some properties to control development in key areas.
In most cases, the authority will acquire property in Decatur and only hold it for a short time, Menne said. This ensures it is acquired by a business that the city supports and will be a good addition to downtown or the other commercial districts. For some locations, it makes sense for them to retain ownership and manage it.
For example, the DDA owns the properties at 113 and 115 Clairemont Avenue, which includes the Welcome Center and the storefront recently vacated by candy retailer Rocket Fizz.
The authority is in the process of looking at potential new tenants for that space, Menne added.
And, they are considering leasing to some smaller tenants who would share or divide up the larger space.
"We have that space to support smaller local businesses, particularly ones that aren't restaurants, who would be a good addition to the Square," she added. "It might make more sense for two or three different businesses to go in there than for one business to be responsible for the larger space."
The DDA also owns the old train depot currently occupied by The Kimball House, which leases the building.
On the expense side, the DDA's largest expenditure is expected to be $480,140 in management fees paid to the City of Decatur. This money covers a portion of the salary and benefits of city employees, including Menne, who support the DDA. The authority has a management services contract with the city, which stipulates the amount to be paid to the city for the services provided by these employees.
Other major expenses include: $150,000 in professional service fees to attorneys and consultants who work on specific DDA initiatives like the office space marketing campaign and the Cottage Court development; and $141,000 and $135,418 for mortgage payments on the properties at 252 S. Columbia Drive and 113 and 115 Clairemont Avenue. The city contributes a portion of the cost of the mortgage on these properties.
The authority also provides some front-end support for many city events like the Decatur Beer Festival and Beach Party and is then reimbursed for some or all of those expenses, Menne told board members during the initial discussion of the budget.
For example, they often contract with third-party services for clean-up after festivals, but are then reimbursed by the festival for that cost.
"That way we are actually overseeing the logistics of a lot of these large festivals to make sure they are done the way we want them to be."
In other business, Menne noted that the DDA board will also be adding two new members this year, as member Fisher Paty is stepping down. Board member Scott Kentner resigned from the board after moving to Brevard, NC, over the summer.
Board members are required to be owners of commercial property or have a business interest in the City of Decatur, Menne said.
Interested residents should fill out the statement of interest for the board on the city's website.The City Commission will decide and make the appointments.

redpajama_set_name: RedPajamaCommonCrawl


Furniture — This furniture, is one of the 22 designs published under the gallery: Outstanding Designs With Bathroom Vanity With Vessel Bowl. In the next page, we have the epic design ideas using rectangular cream rugs and silver single hole faucets also with rectangular white wooden vanity cabinets [ ... ]. While in	the previous page, we have the entrancing design ideas using round glass sinks and silver single hole faucets also with rectangular black wooden vanity cabinets [ ... ].


The capital and most important city of Wales, Cardiff is home to the Welsh National Assembly. Once a coal-exporting center, downtown Cardiff Bay is now in the midst of a modern transformation, full of youthful energy, with a hub of restaurants and nightlife. But history buffs won't be disappointed, as there are plenty of centuries-old sights, including the unusual Cardiff Castle that began as a Roman garrison site in 44 AD.
The gay scene in Cardiff is fun and frisky. Many of the bars, restaurants and the gay sauna are close to one another, on or around Charles Street, St David's Centre and Churchill Way. The main event of the season, and one of the biggest gay events in the United Kingdom, is the Pride Cymru Festival at Coopers Field, a sprawling party in August. Other Summertime events include the Cardiff International Food and Drink Festival, and the Cardiff Harbour Festival.
Cardiff International Airport is about 19 mils from downtown. There are direct flights from London, Dublin, Edinburgh, Paris, Amsterdam, Barcelona, Milan, Munich and Orlando, among other cities. Buses and trains will get you to the center in a snap.
Trains arrive at Cardiff Central from London's Heathrow and Gatwick airports by way of London Paddington Station, or from Manchester on Arriva Wales departing Manchester Piccadilly Station. National Express coaches can get you here from most anyway in the UK, and Eurolines has connections from almost all other European cities.
Cardiff is a walkable city. Buses from Cardiff Bus will get you to the more far-flung sights. Bay Island Voyages offers trips out on the waters of Cardiff Bay for cruises, and one to two-hour coastal explorations.
Visit Wales has an online Out & About article on gay Cardiff, with bars, clubs, hotels, and other listings. Attitude and Gay Times are national UK gay papers with local coverage and listings for Cardiff.
For a city map with locations and website links to local businesses, see our gay Cardiff listings pages.
Church Guesthouse (109 Cathedral Rd; 44 29-2034-0881), Victorian townhouse on quiet tree-lined street, walk to Castle and downtown, traditional full breakfast, WiFi.
Ty Rosa (118 Clive St; 44 845-643-9962), LGBT B&B, straight-friendly, Welsh hospitality, big gourmet breakfasts, optional dinners, cozy common lounge, garden Wi-Fi, free parking.
See more hotels & guesthouses at our map & listings pages.
Eagle Cardiff (39 Charles St, basement), men's club open nightly 5pm-3am, weekends 5am; levi/leather and bears' nights, theme nights, Monday karaoke, male strippers.
Golden Cross (283 Hayes Bridge Rd), friendly neighborhood pub, cabaret shows, bingo, karoake, games, live music ansd comedy, DJ camp classics, home-style food, some of the UK's top male strippers.
Kings (10 Churchill Way), open nightly, weekend warm-up bar for Pulse, karaoke, bingo, diva MCs.
Minsky's Show Bar (St David's Centre, Cathedral Walk), traditional pub, cheap drinks and food, theme nights, weekend diva comedy drag cabaret shows.
Pulse (3 Churchill Way), daytime bar and restaurant, full meals, burgers and snacks; popular nightspot gay/straight-friendly dance and video club, mixed men/women crowd, karaoke, foam parties, student nights; Dreamboys muscle, magic and mayhem every Saturday.
Wow Bar (4 Churchill Way), daily from 9am, hot & cold food and drinks, Sunday roasts, 4pm-8pm drinks specials, live music, karaoke, drag entertainment and DJs every night; Saturday basement dancing and special events.
CLOSED: Bar Icon (60 Charles St), mixed-crowd gay bar, two levels, seven nights 'til 4am dance club.
See two dozen restaurant suggestions at our map & listings pages.
Eagle 50 (50 Charles St), 4-floor men's dry and steam sauna facilities, newly renovated; Jacuzzi, dark room, maze, glory holes, cabins, 2 cinema rooms, cafe/ TV lounge with free internet. Formerly Locker Room.
For more UK cities see: Birmingham, Blackpool, Brighton, Bristol, Leeds, Liverpool, London and Manchester in England, plus Edinburgh and Glasgow in Scotland, and Belfast, Northern Ireland.


Below you will find different materials to accomplish different tasks for which your tank system was likely set up initially.
Replacement materials Level 1 - Level 4, and MMB, are used in raising pH levels typically used for well water where the water is corrosive due to low pH levels. Unlike many other medias, PWF medias are fully blended to produce optimal results, and pre-disinfected to "clean" the tank to prevent bacteriological growth, VERY IMPORTANT WITH WELL WATER.
NOTE: You may access Product and Safety Data Sheets in our TUTORIALS page.
Fully blended and disinfected for true performance as well as disinfection protection against bacterial growth.
1/2 cu ft Bucket Carbon Media.
ACID WASHED SO IT ELIMINATES CARBON FINES SUBSTANTIALLY, much better than water washed or non-washed.


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Mythicomyia rileyi är en tvåvingeart som beskrevs av Daniel William Coquillett 1893. Mythicomyia rileyi ingår i släktet Mythicomyia och familjen svävflugor. Inga underarter finns listade i Catalogue of Life.

Källor

Svävflugor
rileyi

redpajama_set_name: RedPajamaWikipedia


This chapter explores some of the processes that might be necessary for the ground to begin to be cleared in order for recognition and acknowledgement to happen. It reaches back to Chap. 2 of this book in being concerned with what in some ways might be thought of as the first step: the articulation of hurt; or more fully, the conditions of speech and listening. It has quite a simple premise, building on some of the material previously described: that for it to be possible to lay the ghost of destruction to rest, it is necessary first to give it a voice. Put more prosaically, the claim that trauma leads to silence is again disputed, this time because it seems that it is not so much that potential narratives of suffering are inexpressible, leaving the subject silent, but rather that they are silenced. That is to say, the first task of the witness might be to find a way to communicate that the speech of testimony can be endured. This involves the witness staying in the situation and making it possible for the testifier to do so as well and therefore to begin to speak, however hesitantly and uncertainly – this hesitation often being a response to previous failures of witnessing, previous rebuffs. In human affairs, the claim is, there is no such thing as silence; there is always at least a murmur or hint of something amounting to incipient speech. Frequently, however, especially when what is being murmured is disturbing, it is silenced in an active way, it is resisted and so ceases to be audible. The act of silencing is quite often conscious, as those in power or responsible for past and present violence do not want the stories to be told. But silencing can also be unconsciously determined, despite the apparent wish of the witness to comprehend what is being said. This happens because the witness becomes over-excited or stares blankly back at the testifier, unable to connect with horror; or perhaps the position of being an implicated witness becomes too painful to manage, and the witness withdraws. Many of us will recognise this in ourselves: we know we should be listening carefully to something, but somehow we cannot manage it; our attention wanders; we take refuge in clichés and truisms; we fidget or look away; we have somewhere else we need (psychologically) to be. The result is a message back to the speaker that what is being said cannot be listened to, and silence intervenes. Yet the silence is rarely complete; there is almost always some murmur that continues, however much it may need amplifying before it can be fully heard.
Birkbeck Institute for the Humanities. (2013). London Critical Theory Summer School 2013 – Friday Debate II. https://backdoorbroadcasting.net/2013/07/london-critical-theory-summer-school-2013-friday-debate-ii/. Podcast Accessed 2 Jan 2019.


You expressed yourself: "Since the arrival of Alfred Ndengane, Bucs is nt doing well..."
You expressed yourself: "Fill in the missing word from those given in brackets..."
You expressed yourself: "Bucs Possible lineup against Khosi"
You expressed yourself: "Stixzonenic never been finished but a long break!"
Stixzonenic wrote an express yourself article: "Eclairs Chiefs will beat Dunus at the Shell Garage!"
@Mabukwayimfene.. aka Bukwayinja.. Uthini mafikizolo?
Stixzonenic will remain the only blogger indorsed by Puma.


text:
require 'rails_helper'

RSpec.describe Case::FOI::TimelinessReview, type: :model, parent: :case do

  let(:time_review) { build_stubbed :timeliness_review }

  describe 'has a factory' do
    it 'that produces a valid object by default' do
      Timecop.freeze time_review.received_date + 1.day do
        expect(time_review).to be_valid
      end
    end
  end

  describe 'mandatory attributes' do
    it { should validate_presence_of(:name)            }
    it { should validate_presence_of(:received_date)   }
    it { should validate_presence_of(:requester_type)  }
    it { should validate_presence_of(:delivery_method) }
    it { should validate_presence_of(:type)            }
  end

  describe 'state_machining' do

    context 'drafting state' do
      it 'has an FOI state machine' do
        allow(time_review).to receive(:current_state).and_return('drafting')
        expect(time_review.state_machine).to be_a ConfigurableStateMachine::Machine
      end
    end

    context 'unassigned state' do
      it 'has a Configurable State machine' do
        allow(time_review).to receive(:current_state).and_return('unassigned')
        expect(time_review.state_machine).to be_a ConfigurableStateMachine::Machine
      end
    end
  end
  describe 'type' do
    it 'is a type' do
      expect(time_review.is_a?(Case::FOI::TimelinessReview)).to be true
    end
  end
end

redpajama_set_name: RedPajamaGithub


This qualification allows individuals to develop basic functional knowledge and skills for work in customer contact positions in the sport or community recreation industry.
These individuals are competent in a range of administrative activities and functions within a team and under supervision. They are involved in mainly routine and repetitive tasks using practical skills and basic sport and recreation industry knowledge. They work in locations such as sport and recreation centres or facilities, and leisure and aquatic centres assisting with the conduct of recreation activities, and facility maintenance and operations.


This entry was written by whyevolutionistrue and posted on August 29, 2012 at 12:36 pm and filed under animals, photography. Bookmark the permalink. Follow any comments here with the RSS feed for this post.	Both comments and trackbacks are currently closed.
I am puzzled why the last one was selected. It is only my subjective judgment of course, but I think it looks very generic. The other 4 truly captures wildlife moments in beautiful ways.
The bear is benefiting from road kill?
I was thinking that the photographer should have waited a bit more, the unlikely event looks even more like a setup if it catches the bear starting in on a road kill.
Amazing how so much of the drama in nature revolves around who eats whom. We're quite removed from that in our modern lives.
That's some good photography, too. The on-camera flash on the rays is well-balanced. I'd have liked the flash to have been off-camera, but I can certainly appreciate how challenging that would have been, and I doubt any photographer in the real world would have been able to do better with the scene.
My favorite — and I'm surprised you didn't include it above, Jerry — was the mirrored infrared cheetahs.
It's definitely worth playing the slideshow at the link.
I have to agree, that's a really stunning picture.
"Enjoy our slideshow previewing the 50 superb commended and specially commended images from the 2012 Veolia Environnement Wildlife Photographer of the Year competition.
Nice — thanks! I just wish it wasn't one of those really crappy Flash slideshows.
And I still like the cheetahs the best….
The British fox at around frame #43 & the pouncing cat in the long grass at around #46 ~ what cat is that anyone?
I do agree the last one doesn't seem to fit as it does not seem as striking and unique as the previous images.


text:
Association of California School Administrators
Start thinking about ethnic studies requirement now
LEAs will want to start thinking about how to implement the new high school ethnic studies course requirement, according to a recent client news brief from the law firm Lozano Smith.
On Oct. 8, 2021, Gov. Gavin Newsom signed into law Assembly Bill 101, which will require all Local Educational Agencies including charter schools, serving high school students to provide a full-year course in ethnic studies to high school students by the 2025-26 school year. AB 101 also will require completion of a one-semester course in ethnic studies as a high school graduation requirement for students graduating in the 2029-30 school year and beyond.
A similar bill was vetoed last year due to the lack of a fully developed model curriculum. A model ethnic studies curriculum was adopted by the State Board of Education on March 18, 2021.
There are four ways LEAs can develop their ethnic studies course:
They can develop a course based on the model curriculum;
They can offer an ethnic studies course taught as part of a course approved under the A-G requirements of the University of California and the California State University;
They can utilize an existing ethnic studies course currently being offered by the LEA; or
They can utilize a new locally developed course approved by the governing board over the course of two public meetings with an opportunity for public input.
To satisfy AB 101's requirements, an ethnic studies course must meet the following additional criteria:
The primary content must be ethnic studies;
The course must be appropriate for use with students of all races, religions, nationalities, genders, sexual orientations, and diverse ethnic and cultural backgrounds, pupils with disabilities, and English learners;
The course must not teach or promote religious doctrine; and
The course cannot reflect or promote any bias, bigotry, or discrimination against any person or group of persons based on a protected characteristic.
AB 101 does not require an LEA that develops its own ethnic studies course or maintains its existing ethnic studies course to submit its curriculum to the California Department of Education for approval and, at this point, it does not appear that such a course will be subject to a CDE audit. However, the ethnic studies course materials could be subject to Williams Act complaint similar to other instructional materials.
AB 101 also does not provide the opportunity for parents to opt their children out of this graduation requirement. The California Legislature has expressly authorized opt-outs for certain other graduation requirements, but these categories are very narrow and primarily relate to instruction in health and/or sexual health. AB 101 is purported by its authors to provide students an opportunity to learn about cultures, backgrounds and histories outside of existing European-centric teachings.
As noted above, AB 101 provides flexibility for establishing new ethnic studies courses, with a clear directive to ensure it is appropriate and does not disparage any students of any background. LEAs should also be mindful of controversies that may arise during the development of the model ethnic studies curriculum and be wary of efforts to relate AB 101 to other political issues. However, with existing laws already in place restricting LEAs from compelling students to have a particular world view, religious belief or political opinion, the ethnic studies course requirement should be implemented like other history and social science course offerings.
www.acsa.org
© 2021 Association of California School Administrators


This block can have any number of inputs that have the same shape, and merges them along a specified axis.
Concatenating can be useful to merge features coming from different parts of the model towards the end (for instance merging image features with tabular data when estimating the price of a house), or joining together multiple images that are tiles of a bigger map. The output has the same size as the sum of all sizes of the input along the axis to concatenate, and the same shape for all other axis, if any.
Axis along which to concatenate.


text:
Indonesian tanks during a parade marking the 74th anniversary of the Indonesian armed forces in Jakarta, Oct. 5, 2019 (AP photo by Tatan Syuflana).
Indonesia's Military Modernization Must Go Beyond New Hardware
Evan A. Laksmana Thursday, July 8, 2021
When Japan signed a deal with Indonesia in March enabling it to export defense equipment to the Southeast Asian country, some media outlets highlighted the supposed shared interests between Japan and Indonesia in countering China. According to the Associated Press, for example, the agreement would allow the two countries to "strengthen their military ties in the face of China's increasingly assertive activity in the region." But a closer look reveals that Tokyo and Jakarta have very different reasons for signing the agreement.
While Japanese officials stressed the need to deter China and prevent it from making unilateral changes to the status quo in maritime hotspots, the press release from the Indonesian Defense Ministry did not mention China or even the South China Sea. Instead, it focused on the deal's significance for defense technological and industrial cooperation, capacity building, and education and training. These focus areas reflect Defense Minister Prabowo Subianto's multibillion-dollar efforts to modernize Indonesia's military. ...


text:
Nov. 24 Premarket Briefing: 10 Things You Should Know
U.S. stock futures fall Tuesday after Turkey shoots down a Russian warplane, triggering new global tensions.
Joseph Woelfel
Nov 24, 2015 6:58 AM EST
Here are 10 things you should know for Tuesday, Nov. 24:
1. -- U.S. stock futures fell Tuesday after the downing of a Russian jet by the Turkish military triggered new global geopolitical jitters.
Turkey shot down the Russian warplane that it said had violated Turkish airspace and ignored repeated warnings, the Associated Press reported. Russia denied the plane crossed Syria's border into Turkey. Russia's defense ministry said the pilots parachuted but there has been no contact with them.
European stocks declined while Asian shares finished the session mixed.
2. -- The economic calendar in the U.S. on Tuesday includes the second estimate of third-quarter Gross Domestic Product at 8:30 a.m. EST, the Case-Shiller 20-city Index for September at 9 a.m., and Consumer Confidence for November at 10 a.m.
Must Read: 5 Tech Stocks George Soros Loves for 2015
3. -- U.S. stocks on Monday declined as worries over crude prices re-emerged, pressuring commodities and equities as the S&P 500 slipped following its best week of the year.
The Dow Jones Industrial Average fell 0.17% on Friday, the S&P 500 slid 0.12%, and the Nasdaq was down 0.05%.
4. -- Xerox (XRX) - Get Xerox Holdings Corporation Report disclosed that billionaire investor Carl Icahn bought a 7.1% stake in the company.
Icahn believes Xerox shares are undervalued and intends to discuss with the company's board means of improving the company's performance, including strategic alternatives such as a change in the board, according to a filing with the Securities and Exchange Commission.
Xerox, the printer and copier maker, said last month it would launch a review of its business after it posted its first quarterly loss since 2010.
The stock has fallen 21% over the past 12 months. It rose more than 7% in after-hours trading on Monday and jumped more than 3% in premarket trading on Tuesday.
5. -- Bill Ackman's Pershing Square Capital Management raised its stake in Valeant Pharmaceuticals (VRX) to 9.9% from 5.7%, according to a regulatory filing.
Valeant has found itself at the center of a national debate about runaway drug prices. Federal prosecutors have subpoenaed documents tied to its pricing and practices. The company focuses on buying smaller drug developers and then hiking prices on medicines owned by that company.
The stock closed Monday at $87.41, off 67% from its high of $263.81 set in early August.
6. -- Apple (AAPL) - Get Apple Inc. Report plans to launch its new Apple Pay electronic-payment service in China by early February, The Wall Street Journal reported, citing people familiar with its discussions.
Apple has struck deals recently with China's big four state-run banks, the people told the Journal. The deals will allow potential Apple Pay users to link the service with their local bank accounts.
The effort could still face regulatory hurdles in China, the people said. Apple hopes to launch the service before China's Spring Festival holiday on Feb. 8.
7. -- Federal Reserve Chair Janet Yellen on Monday argued for a cautious approach to the pace of interest rises in an exchange with U.S. consumer advocate Ralph Nader, Reuters reported.
In a letter to Nader, Yellen repeated recent statements that the central bank should only gradually raise interest rates.
"An overly aggressive increase in rates ... would undercut the economic expansion, necessitating a lasting return to low interest rates," Yellen said in the letter.
Nader published an open letter to Yellen on Oct. 30 that asked her to consider the "humble savers" with money in banks and money market accounts who were "frustrated by the Fed's low rates and melodramatic debate about when to move higher," Reuters reported.
8. -- Skyworks Solutions (SWKS) - Get Skyworks Solutions, Inc. Report withdrew its takeover bid for chipmaker PMC-Sierra (PMCS) after Microsemi's (MSCC) offer of $2.3 billion gained the support of PMC-Sierra's board.
Skyworks said in a statement that it won't modify the bid and said it's entitled to an $88.5 million termination fee from PMC-Sierra.
9. -- Luxury jeweler Tiffany (TIF) - Get Tiffany & Co. Report posted fiscal third-quarter adjusted profit of 76 cents a share on sales of $938.2 million, down from $959.6 million a year earlier.
Tiffany said it expects 2016 earnings down 5% to 10% from $4.20 a share in fiscal 2015.
10. -- Earnings are also expected Tuesday from HP Inc. (HPQ) - Get HP Inc. Report , Dollar Tree (DLTR) - Get Dollar Tree, Inc. Report and Campbell Soup (CPB) - Get Campbell Soup Company Report .
InvestingStocks


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text:
Extended Release Formulation of PAH Therapy Ralinepag Shows Promise in Phase 1 Trial
by Alice Melão, MSc | July 12, 2017
Results of a Phase 1 clinical study in healthy volunteers evaluating different formulations of Arena Pharmaceuticals' prostacyclin receptor agonist, ralinepag, for the treatment of pulmonary arterial hypertension (PAH), showed the drug's extended release (XR) formulation can achieve a similar body distribution profile as its immediate release (IR) capsule formulations, but with fewer intakes.
Ralinepag (APD811) is an orally administrated investigational drug candidate discovered and developed by Arena. Preclinical and clinical studies have demonstrated that ralinepag can promote the dilation of blood vessels while inhibiting the proliferation of vascular smooth muscle cells and platelet aggregation. Combined with a stable formulation and an extended half-life, these therapeutic effects can be very beneficial for the treatment of PAH.
Recently completed, the Phase 1 study compared the safety, tolerability, and distribution profiles of ralinepag XR tablets administrated once daily with ralinepag IR capsules administrated twice daily.
The IR forumulation is currently under clinical development and is expected to promote continuous exposure, while the XR formulation may improve the drug's distribution in the body with less drug intakes.
The company expects that oral ralinepag XR tablets can achieve a similar body distribution profile as that reported for current prostacyclin therapies administrated intravenously, such as Remodulin (treprostinil) and Flolan and Veletri (epoprostenol).
Twelve healthy volunteers were included in the study and received single daily doses of ralinepag XR. Three different doses were tested. Participants also received single doses of the IR formulation.
Overall, the XR once-daily tablet regimen was shown to reduce maximum plasma concentration of the prostacyclin receptor agonist compared to the IR formulation administrated twice daily. Both ralinepag formulations and regimens maintained similar total plasma concentrations of the drug.
These results suggest that ralinepag XR can potentially promote the same therapeutic effects with the same effectiveness as its IR formulation.
Ralinepag XR's most common treatment-related adverse events were similar to those observed previously for ralinepag IR in healthy individuals.
"We believe the results from this trial support the delivery of ralinepag as a single daily oral dose for patients with pulmonary arterial hypertension," Preston Klassen, executive vice president of research and development and chief medical officer of Arena, said in a press release.
"We will evaluate these data further in the context of the Phase 2 data with ralinepag IR that are expected in July," Klassen added.
Currently, ralinepag IR is being evaluated in two placebo-controlled Phase 2 clinical trials (NCT02279160 and NCT02279745). These studies are evaluating the effectiveness of ralinepag IR in treating pulmonary vascular resistance and improving the exercise capacity of PAH patients after short and long-term ralinepag treatment.
APD811, Arena Pharmaceuticals, clinical trials, extended release, formulation, immediate release, prostacyclin receptor agonist, ralinepag


OpenShot is an award-winning free and open-source video editor for Linux, Mac, and Windows. Create videos with exciting video effects, titles, audio tracks, and animations. Create videos with exciting video effects, titles, audio tracks, and animations. cities skylines how to build freeway intersections • Some audio files may not import correctly or may not link correctly, please send us any samples you experience issues with • Some QuickTime files may import with audio at the incorrect length.
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Lightworks Pro is useful if you really like its insanely customizable interface, autosaving for every action you perform (so you don't need to remember to save your project), and more old-school speed-changing audio scrubbing.
MKV is the best choice to store ripped DVD movies, because it supports unlimited audio and subtitle tracks. However, MKV is not a popular video format for most video player and editing software. If you want to edit MKV file in Windows Movie Maker, Apple Final Cut, or Adobe Premiere, you should convert it into some popular video format, like MP4.
Tips for Cutting Music Reading a Waveform. A waveform is a graphic representation of a sound wave. It gives you an idea of the volume of sound at various track segments.


Australian Croat Steve Kustro on Sunday completed his 36 day of long walks with Our Beautiful. 7 started. May from Dubrovnik, and its "Humanitarian Walk" completed 11. June in Vukovar. The aim of the humanitarian action was to raise as much money as possible to help the unlucky children in Croatia, but to point out all the problems that Croatian citizens face today, but also the fact that they are not alone because they have always been with them - the Croatian diaspora.
How was it "to walk" with Croatia, how much money did you get for this humanitarian action?
"Humanitarian walk" I finished yesterday (Sunday) at 17 hours in Vukovar. I collected about 137 thousand. But the humanitarian action itself is still not finished, everyone willing to help unkempt Croatian donations can be paid by the end of June.
We remind our readers, why did you even decide on this tough, but praise a worthwhile action?
Diaspora has always helped Croatia. We always wanted to help and assist as much as we could. We have never asked anything from Croatia, but we have always been prepared to do everything for Croatia. This was my form of help. I was born in Australia, my whole life is in Australia, but I never forgot where my family was, so my homeland decided to help in this way.
So you're an Australian born, but you love Croatia more than anything, how do you do that?
Croatia is in my heart and my soul!
How many miles are you walking on?
I walked on 36 days, traveled around 1122,9 kilometers, from Dubrovnik to Vukovar, all to help unlucky children in Croatia, to help at least to make Croatia better.
And, how was it to walk with Our Beautiful?
It was wonderful. Croatia is a very beautiful country, people are good, friendly, willing to help, but there were also some negative comments.
From the unimportant individuals who did not appreciate the significance of these small, and my great actions.
But most people still supported you - from donations through accommodation, or at least paid lunches, etc.?
Yes, many helped me - they offered me accommodation, lunch, or at least coffee. Many responded to the action, paid the donation. There are plenty of good people in Croatia.
How do you look at the political and economic situation in Croatia?
Where is the "reset button"?
What would you say for the end?
This is just the beginning, I will continue to fight for the common good, for the better of my dear Croatia.


text:
#ifndef NAMELESSGUI_SIGNAL_HPP
#define NAMELESSGUI_SIGNAL_HPP

#include <functional>
#include <vector>

namespace namelessgui
{

/**
 * A generic Signal class.
 *
 * A Signal can be used to register callback methods which are notified
 * when the Signal is emitted using emit(). The parameters that are passed
 * are specified by the variadic template Params. Registered methods
 * have to match this interface.
 *
 * Example: To declare a Signal that passes an integer and a float to its registered
 * callbacks,
 *
 * @code
 * Signal<int, float> mySignal;
 * @endcode
 *
 * can be used.
 *
 * @tparam Params A set of parameters which are passed to the registered callback
 *                methods.
 */
template<typename... Params>
class Signal
{
public:
	/**
	 * Convenience typedef for a slot.
	 *
	 * A slot basically is a std::function object
	 * which maches the Signal interface of Params.
	 */
	typedef std::function<void(Params... parameters)> slot;

	/**
	 * Connect a new function to the Signal.
	 *
	 * This adds an new callback function to the Signal. On emit(), this function is
	 * called together with all the other registered functions. Note, that the interface
	 * (Signal::slot) of the function has to match the Signal interface Params.
	 *
	 * @param function The function to connect to this Signal.
	 */
	void connect(slot function);

	/**
	 * Disconnect all callbacks.
	 *
	 * This method disconnects all callbacks previously added via Signal::connect().
	 */
	void disconnectAll();

	/**
	 * Emit the signal with a set of parameters.
	 *
	 * This emits the Signal with given parameters. For example, to emit
	 *
	 * @code
	 * Signal<int, float> mySignal;
	 * @endcode
	 *
	 * you can use
	 *
	 * @code
	 * mySignal.emit(100, 2.3);
	 * @endcode
	 *
	 * @param parameters The parameters that are passed to the registered callback functions.
	 */
	void emit(Params... parameters) const;

private:
	/**
	 * Vector that contains all slots registered to this Signal.
	 */
	std::vector<slot> mSlots;
};

template<typename... Params>
void Signal<Params...>::connect(slot function)
{
	mSlots.push_back(function);
}

template<typename... Params>
void Signal<Params...>::disconnectAll()
{
	mSlots.clear();
}

template<typename... Params>
void Signal<Params...>::emit(Params... parameters) const
{
	for(auto iter = mSlots.begin(); iter != mSlots.end(); ++iter)
		(*iter)(parameters...);
}

} // namespace namelessgui

#endif // NAMELESSGUI_SIGNAL_HPP


DNA damage response and DNA repair – dog as a model?
Companion animals like dogs frequently develop tumors with age and similarly to human malignancies, display interpatient tumoral heterogeneity. Tumors are frequently characterized with regard to their mutation spectra, changes in gene expression or protein levels. Among others, these changes affect proteins involved in the DNA damage response (DDR), which served as a basis for the development of numerous clinically relevant cancer therapies. Even though the effects of different DNA damaging agents, as well as DDR kinetics, have been well characterized in mammalian cells in vitro, very little is so far known about the kinetics of DDR in tumor and normal tissues in vivo.
Due to (i) the similarities between human and canine genomes, (ii) the course of spontaneous tumor development, as well as (iii) common exposure to environmental agents, canine tumors are potentially an excellent model to study DDR in vivo. This is further supported by the fact that dogs show approximately the same rate of tumor development with age as humans. Though similarities between human and dog osteosarcoma, as well as mammary tumors have been well established, only few studies using canine tumor samples addressed the importance of affected DDR pathways in tumor progression, thus leaving many questions unanswered.
Studies in humans showed that misregulated DDR pathways play an important role during tumor development, as well as in treatment response. Since dogs are proposed to be a good tumor model in many aspects of cancer research, we herein critically investigate the current knowledge of canine DDR and discuss (i) its future potential for studies on the in vivo level, as well as (ii) its possible translation to veterinary and human medicine.
Mutations in important driver genes, arising from various defects in the DNA damage response (DDR) pathways, can influence the tumor response to treatment. Hence, affected DDR pathways were a basis for the development of numerous clinically relevant cancer therapies. The effects of different DNA damaging agents, as well as DDR kinetics have been well characterized in mammalian cells in vitro. However, very little is known about the amount of actual DNA damage and the kinetics of DDR in tumors, as well as normal tissues in vivo under antineoplastic treatment.
Only few studies utilized individual patient material, and initial DNA damage detection in patient tumor cells was rarely performed. Use of lymphocytes irradiated outside of the patient (ex corpora) [1, 2] revealed individual patient heterogeneity and displayed more background DNA damage in cancer patients vs. healthy individuals [3, 4]. Lymphocytes from human head and neck squamous cell carcinoma (HNSCC) patients irradiated ex corpora need more time to repair DNA double strand breaks (dsbs) than lymphocytes from healthy donors  and greater residual DNA damage was detected with the single cell gel electrophoresis (comet) assay in these patients [1, 2].
Several studies show that addressing DDR in vivo can lead to novel and clinically relevant insights. A non-invasive approach in mouse xenograft tumors revealed a second wave of dsbs, marked by formation of phosphorylated histone variant H2AX (γH2AX) foci, occurring 2 days after the initial wave . The cause of this second, unexpected wave of dsbs is still unknown, with suspected causes of radiation induced genetics instability and apoptosis . DDR studies in ex vivo cultures from normal human prostate tissue treated with ionizing radiation (IR) and cytotoxic agents resulted in different responses of basal versus luminal epithelial cells. The latter lacked γH2AX foci formation completely, despite normal 53BP1 foci formation . Recently, some emphasis has been put on in vivo DDR studies in patients: (i) Base excision- and nucleotide excision repair (BER/NER) measurements in human colorectal biopsies (neoplastic and adjacent normal tissue), revealed patient- but not tissue-specific repair activity . (ii) A study using normal epithelium of human breast cancer patients concludes that S/G2 cell cycle arrest during the course of radiation therapy (RT) leads to greater use of homologous recombination (HR) . (iii) Analysis of HR defects in sporadic human breast cancer patients showed low RAD51 scores being a strong predictive marker of pathologic complete response to chemotherapy . Taken together, these studies suggest that using DDR activity/proficiency as an in vivo readout could lead to a more effective and appropriate treatment of individuals.
Spontaneous tumors in companion animals like dogs have been described to offer a unique opportunity as a model for human cancer biology and translational clinical research . In contrast to many murine tumor xenograft studies, canine tumors develop naturally and grow over long periods of time in the setting of an intact immune system. Human and canine tumors share many similarities, such as inter-patient tumoral heterogeneity, high incidence with age, similar biological behavior concerning development of resistance and metastasis, and comparable responses to antineoplastic agents. Furthermore, several studies indicated that factors of the DDR pathways also affect both disease development and treatment response in dogs [12–14]. As the evolution of most cancers in dogs is shorter than that of humans, conclusions from clinical studies can be drawn faster. Together with the high amount of dog owners willing to participate in clinical studies ([11, 15] own experience), the dog could serve as a model to explore the importance of DDR and especially repair kinetics after antineoplastic treatment in vivo, thus offering opportunities for both human and animal healthcare. However, so far very little is known about DNA repair mechanisms and DDR in the canine background. Herein, we will critically investigate the current knowledge of canine DDR and discuss its potential to provide a basis as a model for DDR in vivo.
Animals spontaneously developing cancer within an intact immune system are proposed to provide an excellent opportunity to investigate various aspects of cancer [16, 17]. As opposed to experimental animals, companion animals are genetically outbred and immunologically competent, thus forming cancers that are more similar to human ones in terms of patient size, cell kinetics and heterogeneity. Moreover, clients (owners) are often willing to participate in well-designed clinical trials. Dogs share physiological and metabolic characteristics for most organ systems and drugs with humans and are large enough for multiple sampling opportunities, diagnostic and treatment interventions. Over the last years, several consortia of comparative oncology collaborations have formed and are managed under the National Institutes of Health (NIH)-National Cancer institute's Comparative Oncology Program (NCI-COP) in order to advance the study of comparative tumor biology and clinical investigations. The yearly cancer mortality rate for dogs < 10 years (deaths due to cancer per 10,000 dog-years-at-risk in Swedish dogs < 10 years) is high with 50% in over 350,000 insured Swedish dogs and varies between breeds . Over 1 million of pet dogs are diagnosed annually and managed with cancer in the United States , and these patients can often be entered in clinical trials when conventional treatments do not meet the goals of the veterinary oncologist. Features of certain canine cancers are already well characterized and show similarities with the human situation [17, 19]. In the following sections we critically discuss, if - based on the current knowledge - the dog can be proposed as a model to study DDR in vivo, as well as point at missing links in this regard.
Are canine and human genomes similar enough to comparatively study DNA damage response and repair?
The canine genome has been sequenced and is available for studies identifying and associating genetically caused diseases, which are of relevance for both animal and human health. Bioinformatic analyses determined that around 94% of the dog genome belongs to regions of conserved synteny between the dog, human, mouse and rat genomes . The euchromatic part of the canine genome is only about 18% smaller than the human genome , but the human and dog genomes differ largely in the chromosome number (46 and 78, respectively). With respect to the common ancestor of eutherian mammals (CAE, 2n = 42), their genome is substantially rearranged. However, mouse and rat genomes are also severely altered with respect to the CAE genome, as they are highly rearranged and have accumulated large numbers of nucleotide substitutions in neutral sites . Nonetheless, the canine gene products seem to be more closely related to their human homologs than those of mice. This suggests potentially higher functional similarity between canine and human proteins, as well as indicates possibly better crossreactivity of human antibodies with canine proteins than with murine ones, especially with respect to DDR proteins (; own observations). The antibody crossreactivity would be especially beneficial in case of functional studies. Humans and dogs share an ancestrally related pathogenic basis for cancer, with pathognomonic genetic changes being conserved in both species . As an example, the BCR-ABL fusion gene could be detected with fluorescence in situ hybridization (FISH) in canine chronic myelogenous leukemia (CML) and chronic monocytic leukemia, which is equivalent to the Philadelphia chromosome (with the BCR-ABL fusion) in human CML showing equal genomic break sites [24, 25]. Besides similarities in protein-coding regions, it is important to keep in mind that the slight differences in the total amount of canine and human genetic material could result in different levels and regulations of the micro (mi) RNAs, which are becoming increasingly relevant. Apart from genetic alterations of proteins, alterations in the miRNA coding regions were shown to affect the regulation of DNA repair [26, 27]. Nevertheless, as it is well established that the canine gene products are very similar to the human ones, the functional read-outs of canine studies based on the protein-coding regions do exhibit a high potential to result in deeper understanding and more accurate predicting of the treatment-response. Involvement of proteomic screens could provide additional insight in this matter.
Are alterations in DNA damage response genes relevant for the development of canine cancer?
In transformed tumor initiating cells with continuously activated DDR, throughout mammalian species, deregulated cell cycle check points and apoptosis mechanisms often prevent an efficient halt of proliferation and cell death induction. Amount of evidence clearly demonstrates that the very similar misregulations occur in both humans and dogs, resulting in genomic instability and tumor progression. Abrogation of p53 function by mutational and non-mutational mechanisms is one of the most frequent tumor suppressor gene inactivations in humans and domestic animals, while p53 dysfunction and MDM2 (ubiquitin E3 ligase of p53) overexpression play a central role in cancer progression [28–31]. Similarly, p16 an important cell cycle regulator encoded by the gene CDKN2A (Cyclin-dependent kinase inhibitors 2A; also called multiple tumor suppressor 1) is often mutated in a variety of human as well as canine cancers [32–34]. Loss of nuclear p16 expression is a prognostic marker for human melanoma and readily described in canine malignant melanoma [32, 35, 36]. P21, a CDK inhibitor regulating cell cycle progression is frequently down-regulated in both human and canine tumors [37, 38]. Consequently, the extent of genomic instability has been described to be equally comparable in certain canine and human tumor types, such as osteosarcoma and colorectal cancer [39, 40]. Taken together present finding clearly indicate that alterations in DDR genes are relevant for development of canine cancer, however to shed more light on tumor-associated defects, further investigations of different canine tumor types with regard to their mutational status and in particular the functional effects of mutations are needed.
Can DNA damage response be compared and transferred between the two species?
Only little is known about the DDR in the normal canine background and its potential alterations in neoplastic tissues. Nevertheless, as discussed bellow, few available studies indicate major similarities between human and canine DDR pathways.
Upon Minute virus of canines (MVC, an autonomous parvovirus) infection classical DDR is triggered in canine cells . ATM activation leads to strong H2AX phosphorylation whereas ATR leads to RPA32 phosphorylation; both of which were also reported to take place in human cells . The MRN complex, which initially recognizes DNA dsbs was additionally visualized. In summary, the ATM-Mre11 axis is induced at the MVC replication centers during infection. To our knowledge the MVC study is the very first example of several important DDR proteins being detected with human antibodies in canine cell lines. Thus suggesting high homology between the proteins of two species. Another study confirmed that the broadly used human antibody against γH2AX is applicable in canine cells as well . Although the MVC study is the only investigation of DDR initiation in canine cells, it: (i) implies similarities between human and canine response and (ii) represents an important starting point for exploring the impact of other stressors on canine cells.
The amount of data directly comparing dsb repair kinetics in human and canine cells is very limited. One study addressing the capacity of nuclear extracts to bind a linear DNA probe (mimicking a DNA dsb)  revealed that in comparison to human extracts, proteins from canine extracts bind with a much lower affinity to linear DNA (28-fold); proteins from hamster cell extracts exhibited further decreased affinity . The mechanism underlying this discrepancy is however not understood yet. Recent comparison of the dsb repair kinetics by pulse field gel electrophoresis (PFGE) after etoposide treatment indicated that the activity of fast non-homologous end joining (NHEJ) repair is 25% lower in canine than human cells, whereas the slow HR pathway seems to be similar. Unfortunately, in this study the relative ratio of migrated to non-migrated DNA was not taken into account, although it differed significantly between the two species . NHEJ reduction in canine background potentially indicates that DNA-PKcs, main kinase in this pathway, could be more important in the primate background. Indeed the intrinsic activity of this protein is 13-fold lower in canine than in human fibroblasts . The draw back of this study however is that it utilized whole cell extracts, in which the overall amount and activity of DNA-PKcs could be influenced by interspecies differences in the amount of cytosolic proteins or other components. Another potential consequence of increased DNA-PKcs activity in human cells is that DNA-PKcs and its partner Ku could bind faster to the DNA break ends in this background. Consequently, the breaks would be protected faster and more often repaired via classical NHEJ in human cells. As DNA-PKcs also regulates the activity of backup-NHEJ pathways, these might be more active in canine cells with less detectable DNA-PKcs . If NHEJ is less active in canine cells, then HR might be a preferred dsb repair pathway.
In addition to above described findings of Park et al. suggesting that HR could be equally active in both species , mutations in different HR components have been analyzed in tumor setting. As BRCA-mutations lead to a higher risk of developing certain types of cancers in humans, the expression levels of these genes were analyzed in dogs with mammary cancer. In canine mammary carcinomas, BRCA2 and RAD51 show similar regulations, which indicates similar functions (Figure 1). In adenoma vs. normal samples, BRCA2/1 and RAD51 expression was reduced. In more advanced adenocarcinomas, however, BRCA2 and RAD51 were overexpressed in about 50% of the cases. Overexpression was even more pronounced in lymph node metastases . Experimental studies are ongoing to clarify if these changes are a direct response to altered genetic stability or if they spontaneously occur during tumor formation. In English Springer Spaniels with mammary tumors, BRCA1 and BRCA2 genes seem to be involved in the development of the tumor . Furthermore, BRCA1 is possibly involved in the malignant behavior . However, the results are sometimes conflicting and more cases have to be analyzed to draw firm and general conclusions.
DNA damages and corresponding repair mechanisms. Various exogenous and endogenous DNA damaging agents attack the DNA on a daily basis. As a result many different types of DNA lesions are generated (green DNA strand with marked damage types (red or written) and green boxes with names of damage types). In order to survive, the cells harbor a set of repair pathways (blue boxes). Important players mutated or misregulated in both canine and human cancers are depicted in the lower part.
Taken together limited amount of data does not allow drawing of strong conclusions about the similarities between dsb repair in humans and dogs. However, there are clear indications that certain pathways such as HR might have higher degree of similarity between the two species. This could be of particular interest in translational research, particularly the one based on synthetic lethality. To fully understand the significance and extent of differences between human and canine NHEJ pathway future studies are needed such as, quantification of phosphorylated DNA-PKcs-foci, NHEJ assays using a pathway-specific substrate, determination of DNA-PKcs protein levels with different antibodies and quantitative mass spectrometry. The activity and efficiency of HR in canine cells needs to be examined in further depth, among others by comparing human and canine Rad51 foci kinetics after the treatment with different genotoxic agents.
Mechanisms like BER and NER have evolved to preserve the fidelity of the genomic material, which is continuously attacked by endogenous and exogenous stressors (Figure 1). The efficiency of the formerly mentioned repair pathways, especially BER, is thought to correlate with lifespan. Though dogs live shorter than humans (16.6 years vs. 90 years, respectively) , the BER capacity of canine and human embryonic fibroblasts under atmospheric oxygen tension (20%) is not significantly different . In contrast to BER, NER activity was shown to be significantly different between the two species (25% lower in dogs) . Performing the assay under physiological oxygen tension (3%), BER activity was also lower in dog cells . These two pathways could therefore vary in activity between the two different species. However, in the case of in vitro assays, the salt conditions and redox potentials influenced the reactions massively, which could explain observed repair differences between the species . Furthermore, cellular growth conditions can influence the total BER protein expression , rendering direct inter-species comparisons difficult. Interestingly, the activity of DNA polymerase β, the key enzyme in filling a single nucleotide gap during BER, was increased in species with shorter lifespan . Though these findings point at intriguing similarities and differences between human and canine excision pathways, as in case of dsb repair, extensive work is needed to understand to which extent DNA repair is comparable between the two species.
In which tumors do we have sufficiently based potential to compare DNA damage repair?
Tumor gene expression studies of BRCA-mutations in malignant canine mammary tumors have shown varied results with under-expression of BRCA1 in malignant, as well as over-expression of BRCA2 in metastatic tumors [46, 47]. As in women, germline mutations also showed a significantly increased risk of mammary cancer development in the examined breed of English Springer Spaniels [18, 19]. BRCA2 and Rad51 expression were proposed as histologic criteria in canine breast cancer staging (Figure 1) . While little is known about the DDR in canine mammary cancer, comparable BRCA2 and Rad51 misregulations, point towards a high possibility of similarly altered HR pathway in the two species.
Compared to men, the incidence of prostatic cancer in dog is low. However, the spontaneous development of the disease in dogs has awoken the interest to use dogs as a comparative model for prostate cancer . The disease in dog behaves similarly to high-grade prostate cancer in men and – although the highly aggressive variant is rather rare in elderly men - the model character can be exploited for treatment strategies such as chemotherapy, vascular targeting, radiation therapy approaches and management of disseminated disease.
Canine osteosarcoma has been shown in many studies to be a valuable comparative model, as it has many similarities on the genetic level, in clinical and biological behavior and in metastasis formation [52, 53]. Case collection is more rapid, as osteosarcoma is much more common in dogs than in man. Common genetic and molecular alterations affect p53, retinoblastoma protein (Rb), c-Met, GH and IGF-1 . So far, little is known about DNA repair in canine osteosarcoma. In many DDR studies, the human osteosarcoma cell line U2OS was used and in further studies findings should be compared with canine osteosarcoma cell lines.
Physical factors, such as cumulative exposure to DNA damaging agents, such as UV-radiation, and viral factors, such as papilloma-viruses, have been described as causative agents in canine cutaneous neoplasia. Canine skin tumors may also be induced directly through genetic mutations in factors such as p53 [54, 55]. In two of the common malignant tumors of the skin, squamous cell carcinoma and melanoma genes and proteins regulating the cell cycle and cell death are affected. The p53 protein was shown to solely localize to the cytoplasm in many tumor cases . P16 expression was significantly reduced . Both proteins usually cause cell cycle arrest or delay, which provides the time for DNA repair or the induction of apoptosis in the case of heavily damaged cells. Therefore, misregulation of important tumor suppressor genes leads to genomic instability and progression of canine melanoma of the skin .
Non-Hodgkin's lymphoma (NHL) represents the fifth leading cause of death due to cancer in humans and the high frequency of malignant lymphoma (7-24% of all canine tumors) in dogs continues to increase as well. Chronic myelogenous leukemia (CML), sporadic Burkitt lymphoma (BL) and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) are three well-characterized hematologic cancers that are morphologically similar in both species . The common genetic mutations and altered oncogene or tumor suppressor gene expression, as well as signal transduction alterations (including N-ras, p53, Rb, and p16 cyclin dependent kinase aberrations), have been reported to occur similarly in human lymphomas as well as in dogs [14, 56, 57]. In human chronic myelogenous leukemia (CML), an aberrant BCR-ABL fusion transcript is the hallmark of the disease . The aberration is seen in more than 90% of adult patients . It was demonstrated that expression of BCR-ABL leads to the direct down-regulation of DNA-PKcs . This proteasome-dependent degradation leads to a marked DNA repair deficiency and explains how secondary genetic alterations accumulate in CML. In five cases of canine CML, BCR-ABL translocations could be detected as well, affecting 11 – 34% of the cells . Therefore, tumorigenesis of CML seems to be similar to the human malignancy. In the canine situation however, an additional down-regulation of DNA-PKcs still has to be verified.
In summary the five depicted tumor types are highly adequate models to translationally study tumor biology and treatment responses. We postulate that these tumors can also be used to study the DDR in vivo. In many of these tumors, cell cycle control proteins are altered, thus indicating increased genomic instability and DDR defects in spontaneously developing canine tumors.
In order to answer the question if studies in dogs have potential and perspective to serve as an in vivo model for DDR a positive outlook can be granted. Integrating spontaneous canine tumor models has several important advantages. Due to the high caseloads in veterinary clinics and shorter lifespan, studies can be performed quite fast. Cancers occurring in dogs and humans arise naturally with age, in the background of an intact immune system. They comprise many common features like histological appearance, tumor genetics, molecular targets, biological behavior and response to conventional therapies. Moreover, in many terms a canine model will even serve better than the murine one to study DDR and its defects in vivo, as in mice certain repair pathways seem to be less active in comparison to the human mechanisms. Therefore, mice have potentially a different emphasis and hierarchy of DNA repair pathways . As described above, rather little is known about the DDR in canine cells and tissues. However, the antibody cross-reactivities of the human and canine proteins and the findings summarized in this article clearly show that the DDR of dog cells is potentially highly similar to human cells. In order to use canine tumor patients as models, the regulation and kinetics of the canine DDR will have to be studied more thoroughly at the biochemical and cellular level, by gene and mutational analyses as well as by global molecular pathway studies aiming to elucidate the similarities and differences to human cancers. In this way, the dog as our closest companion can help to better understand the DDR in vivo and to verify new treatment strategies on the DNA level in vivo.
Barbara van Loon and Carla Rohrer Bley contributed equally to this work.
We thank Jeanne Peter Zocher for the design of the illustration. Additionally we acknowledge the critical revision of the manuscript by U. Hübscher and F. Freimoser.
NG: Conception, design and writing. BvL: Conception, design, critical revision. CRB: Conception, design, writing and critical input. All authors read and approved the final manuscript.


Here is presenting some of the most interesting slideshows on User Experience.
An introduction to the factors that affect and define user experience. A basic overview for beginners.
Tips and guidelines to follow while designing for good user experience along with screenshots as examples.
Common myths about user experience are disclosed and discussed here.
Introduces the basic principles of user experience with suggestions for designing good online and offline experiences.
via Netbramha , a design studio based out of Bangalore.


text:
SavATree Makes First Indiana Acquisition with Vine & Branch
PR Newswire December 24, 2019
SavATree, the industry leader in professional tree, shrub, and lawn care has announced the acquisition of Vine & Branch of Carmel, Indiana. This acquisition opens up the Indianapolis metro area to SavATree, further expanding their Midwest reach.
BEDFORD HILLS, N.Y., Dec. 24, 2019 /PRNewswire-PRWeb/ -- SavATree, the industry leader in professional tree, shrub, and lawn care has announced the acquisition of Vine & Branch of Carmel, Indiana. This acquisition opens up the Indianapolis metro area to SavATree, further expanding their Midwest reach.
"Vine & Branch has served the region for over 40 years," said Daniel van Starrenburg, CEO of SavATree, "and in that time, they've become a key resource for their community. We're really looking forward to partnering with such a well-respected team and working together to grow our presence in the area."
Vine & Branch was founded in 1976 and has provided quality tree care and plant health care ever since. During the transition, Registered Consulting Arborist and President of Vine & Branch, Jud Scott, will help ensure a smooth integration, while all arborists and crew members will continue to serve clients. As a result of the merger, customers will now have access to a larger menu of services options, including professional lawn care with a full complement of organic treatment options.
"We're lucky to have found a partner that places as much value in safety and personalized care as we do," said Jud. "We're excited to be a part of SavATree."
About SavATree
SavATree provides environmentally sensible tree, shrub and lawn care to residential and commercial properties throughout the Northeast, Mid-Atlantic, Southeast, Midwest and Western regions. Property programs feature organic and hybrid plant health care, lawn care and general tree care—all highly customized to meet the needs of each landscape and steward. Services include tree and shrub pruning, insect, mite and disease management, deer deterrence, and professional lawn care, as well as tree and shrub nutrient/fertilization programs.
Learn more at http://www.savatree.com
SOURCE SavATree
There's One Good Reason for Why Onions Make You Cry
China's Tencent Music revenue misses estimates, share fall 4%


text:
Guy Pearce & Matilda Lutz Board Andrew Baird's Sci-Fi Thriller 'Zone 414'
'Song Of Back And Neck' Tribeca First Look: Paul Lieberstein Makes Adjustment To Directing Movies
Patrick Hipes
Executive Managing Editor
More Stories By Patrick
Paramount Network's '68 Whiskey' Ratings Off Like A Shot
CAA Revamps Management Structure, Creates First CAA Board
EXCLUSIVE: The Office alum Paul Lieberstein's feature directorial debut Song of Back and Neck is making its world premiere today in the U.S. Narrative Competition section at the Tribeca Film Festival. The pic stars Lieberstein and Rosemarie DeWitt; Lieberstein, the Office regular who became the series' showrunner later in its run, stretches his legs as a feature writer-director after helming TV episodes including The Mindy Project and The Newsroom.
In the dark comedy he plays Fred Trolleycar, who is on a journey to find a cure for his chronic back pain. Along the way he discovers an unusual talent, finds unexpected love (with DeWitt), and that his feelings may have been the cause of his pain all along. Brian D'Arcy James, Sam Anderson, Robert Pine, Clark Duke, Ike Barinholtz and Paul Feig co-star. The movie was inspired by Lieberstein's own struggles with back pain; he was healed after his wife gave him a copy of Dr. John Sarno's book Healing Back Pain.
Lieberstein, Jennifer Prediger and Kim Leadford are producers. Fernando Loureiro, Roberto Vasconcellos, Allen Babakhanloo, Fouad Mikati and Lauren Russell are executive producers.
Song of Back and Neck bows this afternoon at 5:30 PM ET at the SVA Theater 2 Beatrice. CAA is handling sales.
Check out the clip above.
Paul Lieberstein
10 Terry Jones: UK Comedy Legend & 'Monty Python' Co-Founder Dead At 77


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'There's an assumption that people in hospital aren't using': Ontario hospital leading the way on harm reduction for users
Justin Zadorsky CTVNewsLondon.ca Web Writer
Published Friday, April 23, 2021 10:00AM EDT Last Updated Friday, April 23, 2021 11:57AM EDT
LONDON, ONT. -- London Health Sciences Centre (LHSC) will become the second hospital system in North America to use harm reduction strategies, such as safe injection sites, for patients who use methamphetamines.
"There is an assumption that people in hospital aren't using," said Dr. Michael Silverman with Lawson Health Research Institute (Lawson) in a release.
"But in fact we've found that almost 50 per cent of patients are injecting drugs during their stay." Silverman added they believe that number to be an underestimate due to those not willing to admit they are using while in hospital due to stigma.
According to Lawson, recent studies out of London, Ont. have found that patients using in hospitals have a greater risk of infection than if they use in the community.
Harm reduction strategies such as safe injection sites are already in use within the community.
In November, a permanent safe injection site at 446 York St. in London was given final approval from the province of Ontario.
"Harm reduction strategies are rarely used within hospitals in Canada. The current standard of care does not allow the use of illicit substances in hospitals as the safe consumption of substances requires an exemption under section 56.1 of the Controlled Drugs and Substances Act from Health Canada," explains Dr. Cheryl Forchuk with Lawson.
There are only five known hospitals in the world that use harm reduction strategies with LHSC being the second in North America.
Harm reduction strategies are safe injection sites or safe places to use substances, new needles and syringes, available Sharp boxes, support for detox and withdrawal, medication, resources at discharge, and enhanced addiction services and counseling.
Lawson findings show that patients are more likely to get an infection from substance use in a hospital. Many will also leave hospital against medical advice to use.
"People aren't able to access safe ways to use substances and they are doing it in secret, so it's not the best way to do it to prevent infection. There are also gaps in support for withdrawal and other addiction services," said Dr. Silverman.
The research team will lead a four-year project with hopes of recruiting about 360 adults aged 16-35 years with past experience or current use of methamphetamine, including inpatients, outpatients and those in community outreach programs.
Roughly 180 health care and service providers will be recruited to share their perspectives on harm reduction strategies.
After the consultation phase in the first year, with approval from Health Canada, the identified set of strategies will be implemented within LHSC and St. Joseph's hospital sites.
You can watch a video regarding this announcement below:
Permanent London, Ont. safe consumption site gets final approval
Permanent supervised consumption sites get federal approval
Safe injection site bringing additional health benefits
Biden curses after Fox reporter yells question
Graphic content: Random stabbing in coffee shop
Crash leaves London intersection looking like a 'war zone'


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Brady Announces a Departure from his Senior Staff
September 20, 2019 — Press Releases
Washington, D.C. – The top Republican on the House Ways and Means Committee Kevin Brady (R-TX) announced today that Anne DeCesaro, Republican staff director for the Subcommittee on Worker and Family Support, is leaving the Committee staff.
Upon announcement of her departure, Rep. Brady released the following statement:
"Anne's life has been dedicated to the American worker and children in need. Throughout her time on the Hill to her years of service in the executive branch, Anne has championed policies that help workers reach their full potential and give families the tools they need to succeed – including passage of historic reforms to our foster care and unemployment insurance systems, promoting the restructuring our nation's cash-for-work welfare program, and countless other initiatives to help lift low-income families and workers out of poverty.
"My Chairmanship benefited greatly from her expertise and our Committee wishes her all our best as she moves on to this next step in her career, continuing the work of helping every child, worker, and parent flourish and take part in the American Dream."
DeCesaro served as staff director of the Worker and Family Support Subcommittee, previously named the Human Resources Subcommittee, since 2015; and she served as professional staff on the Human Resources Subcommittee staff from 2011 to 2014. In 2015, she was the lead staffer on the House Agriculture Committee Subcommittee on Nutrition, overseeing the nation's Supplemental Nutrition Assistance Program, formerly known as food stamps. Earlier in her career she spent a number of years at the Office of Management and Budget and the Social Security Administration. She received her bachelor's degree from Saint Mary's College and her master's degree from the Johns Hopkins University.


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Q: combining FILTER formula in Google Sheets https://docs.google.com/spreadsheets/d/1St7OTtb69rj00qsq_C7vhtSD1VEUVUL9ekAmguBcc-M/edit?usp=sharing
the case above shows:

*

*there are two tables of data (city and country)

*I can filter each of the data according to a certain category

*I can combine both filter result manually by putting one above another

THE QUESTION:
is there any formula that can combine both filters (city and country) so that we got the expected result as shown in cell J2:J9??

A: use:
={FILTER(A:A, B:B="yes");
  FILTER(D:D, E:E="yes")}

or:
=FILTER({A:A; D:D}, {B:B; E:E}="yes")

or:
=QUERY({A:B; D:E}, "select Col1 where Col2 = 'yes'")

redpajama_set_name: RedPajamaStackExchange


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Van Soest v Residual Health Management Unit [2001] 1 NZLR 179 is a cited case in New Zealand regarding nervous shock cases
.

Background
This case involves relatives of patients that died during surgery under surgeon Keith Ramstead at Christchurch Hospital.

The relatives sued the Residual Health Management in tort for the nervous shock that they suffered as a result of having a relative die.

Held
The Court of Appeal rejected the relatives claim, as they were only claiming they suffered grief, holding that they law required a higher standard for a nervous shock case to be successful.

References

Court of Appeal of New Zealand cases
New Zealand tort case law
2001 in case law
2001 in New Zealand law


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> Home > Huntington Library > Manuscript Collections
∞ https://oac.cdlib.org/findaid/ark:/13030/c8154mfb/
L.L. Whitman correspondence, 1903-1911
mssHM 81903-82022
Contact Huntington Library::Manuscript Collections
Administration Information
Title: L.L. Whitman correspondence
Collection Number: mssHM 81903-82022
Creator: Whitman, Lester L. (Lester Lee), 1861-1932
Extent: 121 items in 3 boxes
Repository: The Huntington Library, Art Collections, and Botanical Gardens Manuscripts Department
The Huntington Library
San Marino, California 91108
Email: reference@huntington.org
URL: http://www.huntington.org
Abstract: This collection consists of letters from L.L. Whitman and his wife to his mother R.J. Whitman, in South Paris, Maine.
Language of Material: The records are in English.
Collection is open to qualified researchers by prior application through the Reader Services Department. For more information, please go to following web site .
The Huntington Library does not require that researchers request permission to quote from or publish images of this material, nor does it charge fees for such activities. The responsibility for identifying the copyright holder, if there is one, and obtaining necessary permissions rests with the researcher.
[Identification of item], L.L. Whitman correspondence, The Huntington Library, San Marino, California.
Purchased from DeWolfe and Wood, February 2015.
Lester L. (Lester Lee) Whitman was born in 1861. He was a well-known transcontinentalist. Whitman made several cross country automobile trips in a Franklin, a Reo, and an Oldsmobile. In Pasadena, California, he owned an automobile manufacturing shop. He held several automobile records including San Francisco, California to New York City in 15 days 2 hours and 12 minutes in 1906. He also made the ascent to Mount Wilson in his 1907 Franklin and said, "Not for five hundred dollars would I make the trip again."
The Whitman correspondence begins on May 28, 1903 in Pasadena, California. Whitman writes to his mother about a potential automobile trip from San Francisco, California to New York and introduces her to his driving partner, E.I. Hammond. The duo will be trailing several hundred miles behind E.T. Fetch and M.C. Krarup, another pair on their way to New York. Whitman writes that he has more faith in his 4.5-horsepower Oldsmobile than the 1903 Packard, which Fetch is driving. Postcards and letters concerning his trip east are sent from various locations including Lovelock and Elko, Nevada, Ogden, Utah, Rawlins, Wyoming, and Elwood, Nebraska. On the road, Whitman and Hammond face mechanical issues, rugged roads, and harsh weather conditions. In one letter, Whitman writes about frightening a lone Indian to death when they approached him in their "machine." In another event, they recruited the help of two cowboys, who used "their lassos to pull us up a bank some 15ft high..." (July 20, 1903). When driving through the country side, the undeveloped roads prove to be difficult: "The country is all mud, terrible. We can make but little progress. This mud is the black adobe like lard and dries hard as flint" (Aug. 13, 1903). In Detroit, Michigan, Whitman meets Ransom E. Olds and appears to be an honored guest at an automobile race with 10,000 people in attendance. Whitman speaks too soon when he writes "I don't want any more endurance runs..." because he dashes across the continent again in 1904, 1906, and 1910 at record-setting rates, which include breaking Fetch's record. Whitman reflects that his automobile trip "helps to season and spice the short life we stay on this earth" (Oct. 18, 1903).
The correspondence resumes in June 1904 in Syracuse, New York. Whitman appears to be preparing for his next transcontinental trip with Charles S. Carris. Whitman and Carris left San Francisco, Californ ia on August 1, 1904 and arrived in New York City 33 days later on September 3, 1904. Whitman writes, "I am well and hearty- and have in my pocket a check for $1,200 – for my labor, pretty good eh?" (September 3, 1904).
After a brief vacation on the east coast, Whitman and his wife arrive home in Pasadena, California on November 13, 1904. At this point in time, the letters mainly concern family, friends, social life, and updates on Whitman's business as a car manufacturer with his partner W.G. Hansen. Concerning car sales, Whitman jokes: "If I can't sell them we can run them into the ocean" (July 11, 1909). There are a number of letters from Syracuse, New York as Whitman was offered a position with H.H. Franklin Mfg. Co. after his trip; however, he did not remain with the company for very long. In late 1910 and early 1911, Whitman and W.T. Harrington opened a garage selling automobiles and supplies in Pasadena, California. Unfortunately, business was "rotten" and the garage was bought out in late February. Besides occupying himself in the automobile industry, Whitman writes often about his vegetable garden, trapping gophers, and his health. He suffered from asthma, frequent headaches, and rheumatism. Thus, there are several letters from hot springs in San Jacinto, California, which he calls a "stinking place."
Much of the correspondence from Pasadena, California consists of letters from Whitman and his wife Sophia in the same envelope. Occasionally, there are letters addressed to an "Elizabeth," possibly a relative in South Paris, Maine. Some of the letters include dried pressed flowers. There are also clippings related to Whitman's travels from the Lewiston Saturday Journal and Pacific Automobiling in 1904. There are two pamphlets that Whitman wrote about his cross country trips: From Coast to Coast in a Motor-Car (1905) and Coast to Coast in a REO (1910). Note: Coast to Coast in a REO was transferred to the Rare Books Department in May 2015. The call number is RB 645458. Lastly, there is one photograph from Whitman's transcontinental trip in 1910.
This collection is arranged chronologically.
Carris, Charles S.
Whitman, Lester L. (Lester Lee), 1861-1932
Hammond, Eugene I. (Eugene Irish), 1880-1948
Reo Motor Car Company
Automobile drivers
Automobile driving
Automobile industry and trade
Automobile supplies industry
Franklin automobile
Hot springs--California--San Jacinto
Oldsmobile automobile
Reo automobile
California--Description and travel
Pasadena--Social life and customs
San Gabriel Mountains (Calif.)--Description and travel
San Gabriel River Valley (Calif.)
Syracuse (N.Y.)
United States--Description and travel
Correspondence (letters)


Cancer cases are sharply rising among younger Americans. An alarming new study sheds light on why. This is very unfortunate news. Researchers looked at 30 of the most common cancer types. 12 of them were obesity-related. Of those 12, six types have risen in younger people. Obesity has been on the rise not just here in America, but around the world. And now adults between the ages of 25 and 49 here in the US are being diagnosed more often with potentially deadly diseases that are associated with obesity.
(WXYZ) — Cancer cases are sharply rising among younger Americans. An alarming new study sheds light on why.
This is very unfortunate news. Researchers looked at 30 of the most common cancer types. 12 of them were obesity-related. Of those 12, six types have risen in younger people. Obesity has been on the rise not just here in America, but around the world. And now adults between the ages of 25 and 49 here in the US are being diagnosed more often with potentially deadly diseases that are associated with obesity.
The report from the American Cancer Society and the National Cancer Institute said that by 2014, obesity accounted for 60% of endometrial cancers, 36% of gallbladder cancers, 33% of kidney cancers, 17% of pancreatic cancers and 11% of multiple myeloma. And that was among adults aged 30 and older. Unfortunately for millennials who are in their 20's and 30's, the risk of colorectal, uterine and gallbladder cancers has doubled compared to decades ago when baby boomers were the same age.
1. Losing weight and keeping it off means a lifestyle change. It has to be gradual and long-term so don't even think about any of the trending diets out there.
2. Please learn about nutrition. It's important to choose the right foods in addition to changing your thoughts towards eating.
3. Increase your physical activity. Just start by moving your body. Take short walks, dance in your home, but aim to do more as your stamina increases.
4. Make sure you have a strong support system. You need loved ones who can support you, especially when eating out, at parties or during traditional holiday meals.
Also, it's really important to talk to your doctor. He or she will do a wellness checkup and can recommend the best diet and exercise program based on your health condition. And if you drop weight and live a healthy lifestyle, this will transfer into a lower risk of cancers that are obesity-related.
This week on The Dr. Nandi Show, "Diet is a Four-Letter Word for Failure". We all know it can be very confusing when it comes to losing weight as there are so many different types of new diets and fads cropping up all the time. But the key is to create a realistic plan that makes healthy eating a way of life. So join Dr. Nandi this Sunday, Feb.10 at 1 p.m. And you'll meet real people who have found a way to permanently lose weight through a healthy lifestyle change.


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Mayfield vs. TB
ArmySooner
Baker has a chance to make the Browns 3-3-1. Browns are only down 7 pretty early in the 4th quarter.
All tied up late. TB's ball.
K2CSooner
Overtime. You can follow it here if you don't have TV. Hope this works. The site auto-updates.
http://www.espn.com/nfl/game?gameId=401030806
I guess it's over? 23-23 tie. What happened to overtime in the NFL?
Baker with a chance to drive for a win here.
I guess I spoke too soon. They are in overtime. I need to brush up on the NFL rules.
NFL OT used to be a straight sudden death - first team to score wins. They found that the team that won the OT coin toss drove for a field goal and thus won a high percentage of the time with the other team never getting the ball. Now, if the first team to posses the ball in OT scores a TD, then the game is over, but if they just get a field goal, then they kick off and the other team gets a possession. If either team is ahead after that possession, they win, if it's still tied, the game continues until someone scores.
I like the NFL OT rules much better than the college rules, because it's more like the regular game.
ClintAAdams
"Now, if the first team to posses the ball in OT scores a TD, then the game is over."
That alone still makes college football OT rules better. My biggest beef with college football OT rules is they shouldn't start so close.
If the game is still tied after a 10 minute overtime period, the game CAN end with a tie.
I just don't watch NFL football unless Baker is playing. I watched the whole game today and was hoping that the Browns could pull off the win...so close but couldn't manage it...lost on a 59 yd. field goal made by a kicker that had missed a extra point and a couple of field goals.
Oklahomazeppelin
Since we're talking about NFL OT rules, I have to say it is simply the worst OT in all of sports. The reason is that it's the only sport that doesn't guarantee equal chances. The only sport. And we've seen it play out, in disastrous proportions again and again.
Seattle, at home, beat Green Bay in the NFC championship after winning the coin toss and scoring a TD; MVP Aaron Rodgers didn't get to play.
Arizona, at home, beat Green Bay in the next year's playoffs after winning the coin toss and scoring a TD; MVP Aaron Rodgers didn't get to play.
New England beat Atlanta FOR THE SUPER BOWL after winning the coin toss and scoring a TD; MVP Matt Ryan didn't get to play.
This is the equivalent of a walk-off run in the TOP of an inning. It is the equivalent of "first basket wins" in basketball OT. It is not equal. It is not fair. College football's OT is quirky. But it is fair.
Clearly the NFL should play a 10-minute period, in full. No sudden death component. Because it's fair.
We now have a Super Bowl coin-toss champion with New England. (And I appear to be the only person on the country to have noticed.)
That said, this doesn't apply to Cleveland today. They won the toss and had chances and only got three-and-outs before fumbling a punt and losing on a 59-yard field goal as OT time expired.


Flexible seating-it's all over social media right now. It's strange to us that it's so popular right now as we've been doing it in our classroom for over seven years, but there is definitely a trend that doesn't mesh with our philosophy of flexible seating.
Flexible seating is a mindset-not an opportunity for shopping!
First of all, flexible seating is a mindset-not an opportunity for shopping. To date we have spent $0 on the flexible seating arrangements in our classroom out of our own pockets and our school has spent about $500 per classroom buying Hokki stools. The stools follow the students throughout their elementary careers.
So please! Stop spending all your hard earned money! We're not saying you're wrong for wanting your classroom to be a beautiful place to work and learn, but it's not necessary. Check out this post for more detail on our seating options or this post on how we manage all the stuff.
Flexible seating is about giving your students choice.
We have taught our students that flexible seating is about finding a place to work independently and efficiently. During the first weeks of school, students have opportunities to try out a variety of options. These options include sitting in a desk that's within a group, sitting in a desk that's alone, sitting at a table, or sitting on the floor with a clipboard (some of our clipboards are literally cardboard with an alligator clip). Students have to justify their favourite choice and we reserve the right to move them if it's not a good fit.
We also allow students to use standard desks. About half of our students prefer having a desk with their own belongings in it. The other half prefer tables and using storage bins. Some years we have more desks and other years with have more tables. It's based on the students.
As the year continues, we introduce other options-sitting at the table in the hallway to work alone, sitting in the stairwell nearby alone, going to the library work space or using the quiet space in our storage closet. Students learn that instructional time seating and work time seating varies depending on the activity.
We encourage our students to advocate for their learning by making a good choice about where they sit. We also implement a three strikes rule. If work is not getting done to our standards, then the specific seating choice is no longer offered.
We created an anchor chart with our students as we were developing independence. It takes our students about a month until they understand how it works (but then we get the rest of the year for free!). There will always be students who try to put one over on us, but when students are held accountable for their work, they tend to make good choices.
The best way to see if flexible seating will work for you classroom is to give it a try. Choose a simple task for students to complete. Explain that students can sit anywhere they like in the classroom, but they have to work quietly (or at your acceptable noise level) and the work has to be done in a specified time. If they can do that, there may be more opportunities. Test this out several times and build an anchor chart with your class about the good and bad of flexible seating. Ask students to come up with seating options. Many of our students end up bringing simple seating options from home (footstools, cushions, mats and a box-a story for another time).
So are you ready to give it a try? Don't let cost be a reason not to. Share your experiences with flexible seating in the comments below.