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PLA2 Signaling
PLA(2) signaling is involved in calpain-mediated degradation of synaptic dihydropyrimidinase
Balanced frequencies are often observed for the centromeric KIR A
Posted on January 31, 2019 by plas9821
Balanced frequencies are often observed for the centromeric KIR A and B haplotypes; the frequency of Cen-A (i.e. characterized by the presence of KIR2DL3, KIR2DP1 and KIR2DL1) in most populations worldwide
is ∼ 50–60%, roughly that which is observed for the extended A haplotype. The notable exception is within East Asian populations,110,111,126 where the frequency of the I-BET-762 price centromeric B haplotype loci KIR2DL2 and KIR2DS2 is generally very low and Cen-A is observed at frequencies greater than 80%; the frequency of the extended (centromeric and telomeric) A haplotype also tends to be highest in these populations. It is interesting to note, however, that these exceptionally high Cen-A frequencies are generally not observed in Amerindian populations,112 suggesting that this shift occurred within East Asia subsequent to the differentiation Pirfenidone nmr of the Amerindians from these populations. Although the loci associated with the full-length motif Cen-B1 (i.e. characterized by the presence of KIR2DL2, KIR2DS2, KIR2DL5, KIR2DS3/S5, KIR2DP1 and KIR2DL1) are very common within Africa,110,112,127 the much shorter
Cen-B2 (i.e. characterized by the presence of the framework genes in addition to KIR2DL2 and KIR2DS2) is observed primarily outside Africa, and this motif largely replaces Cen-B1 in some populations outside Africa (J. Hollenbach, unpublished results). However, there is no clear pattern or gradient associated with this motif, which appears
to be distributed somewhat sporadically across several world regions. African populations in general exhibit substantially greater haplotypic diversity within the centromeric KIR region relative to other world regions. The telomeric portion of the KIR is characterized by a Nitroxoline pattern of variation more closely related to population demographics. As previously noted, the stimulatory KIR3DS1 is found at much lower frequencies in African populations relative to most other world populations;112,128 its frequency increases with geographic distance from Africa.110 Although the African populations exhibit some of the highest frequencies for the centromeric B haplotype loci, the frequency of all telomeric B haplotype activating loci is in general very low in African populations. However, whereas the overall frequency of the extended B haplotype is comparatively low among the Asian populations, extended B haplotype frequencies are relatively high in the African populations. Other world populations generally range between these extremes. It is striking, however, that despite this variation, the worldwide frequency of A and B haplotype heterozygosity is generally stable, with an average frequency of 44%, suggesting that there is a population-level advantage in maintaining these balanced frequencies.
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Curr Protoc Immunol 91:14 16 1-14 16 15 © 2010 by John Wiley
Curr. Protoc. Immunol. 91:14.16.1-14.16.15. © 2010 by John Wiley & Sons, Inc. "
"Inflammatory biomarkers are associated with preeclampsia (PE) and poor fetal growth; however, genetic epidemiologic studies have been limited by reduced gene coverage and the exclusion of African American mothers. Cases and controls (N = 1646) from a pregnancy cohort were genotyped for 503 tagSNPs in 40 genes related to inflammation. Gene-set analyses were stratified by race and were followed by a single SNP analysis within significant gene sets. Gene-level associations were found for
IL6 and KLRD1 for term small for gestational age (SGA) among African Americans. LTA/TNF and TBX21 were associated with PE among European Americans. The strongest association was for PE among European Americans for an upstream regulator of TNF with RR = 1.8 (95% Sorafenib cell line CI 1.1–2.7). Although previous studies have suggested null associations, increased tagging and stratification
by genetic ancestry suggests important associations between IL6 and term SGA for African Americans, and a TNF regulator and PE among European Americans (N = 149). "
"IL-2 selleck products was discovered as a T-cell growth factor that promoted T-cell-dependent immune responses; however, more recent studies suggest that the essential role of IL-2 is to maintain functional Treg and thus control immune responses. These results are leading to new ideas about the potential of IL-2 as a therapeutic strategy in autoimmune diseases. In this issue of the European
Journal of Immunology, a study further examines the role of IL-2 in immune regulation and shows for the first time that IL-2 complexes can ameliorate autoantibody-mediated autoimmunity. This commentary examines the current findings in relation to what we already know about IL-2 complexes. IL-2 was initially discovered due to its activity in vitro as a growth factor for T cells 1, and was first used as a therapeutic approach in humans to boost immune responses in patients with disseminated cancer 2 and advanced HIV disease Cyclic nucleotide phosphodiesterase 3. These therapeutic attempts, however, have had limited success. The generation of mice deficient in IL-2 or components of the IL-2 receptor 4–6 challenged the notion that promoting T-cell expansion and differentiation into effector cells is the main function of IL-2 in the immune system. The observation that mice lacking IL-2 or the IL-2R developed lymphoproliferation and autoimmune disease suggested a growth-limiting, rather than a growth-inducing, function of IL-2. Initial attempts to understand the mechanism underlying the inhibitory role of IL-2 in T-cell responses led to the observation that IL-2 sensitized activated T cells for activation-induced cell death 7. These experiments were mostly done with in vitro T-cell cultures and evidence that IL-2-dependent activation-induced cell death indeed suppresses in vivo T-cell responses remains limited.
Currently, a number of genetic or virus-based approaches are
used to target dividing NSPCs or their progeny to reduce neurogenesis [53–56]. In addition, strategies using optogenetics have recently been developed to manipulate the contribution of new neurones to hippocampal circuit activity [57]. Initial experiments aiming to characterize the functional contribution of new neurones to hippocampus-dependent Metabolisms tumor behaviour predominantly used paradigms designed to test the function of the complete hippocampal circuitry (such as Morris water maze, contextual fear conditioning). However, more recent studies aimed to test more selectively the dentate circuitry by using tasks that specifically challenge this hippocampal subregion [55,58–60]. Guided by electrophysiological and computational FK228 datasheet data addressing the exact function of the DG, it was shown (using a number of gain- and loss-of-function strategies) that new neurones seem to be critically involved in a cognitive
functions called pattern separation, which in simple terms means that highly similar inputs are differentially represented in the output, which is potentially one of the key functions of the DG [55,59,60]. How new neurones contribute (or exert) this function remains poorly understood but it is believed that the period of heightened excitability that young neurones exhibit between 3 and 6 weeks after they are born may be crucial to fulfil this function
[41,43,44,61]. Be that as it may, it is not clear if indeed excitation generated by new neurones onto target pyramidal cells in CA3 is key to understanding their function or if new neurones rather shape the dentate circuitry and network activity by connecting to local neuronal cells such as hilar mossy cells or dentate GABAergic inhibitory neurones [19,41]. Future experiments aiming Molecular motor to analyse in vivo network behaviour after manipulating the number of new neurones (or their activity) will help to further understand how newborn granule cells shape dentate connectivity and function. The finding that neurogenesis does not tamper off with the end of development but continues throughout life initiated a large number of studies using a variety of rodent disease models to study the effects of brain diseases on neurogenesis. Strikingly, a substantial number of psychiatric (e.g. models of major depression) and acute or chronic neurodegenerative diseases (e.g. models of stroke, Alzheimer's disease, epilepsy) were found to have a profound effect on hippocampal neurogenesis [5].
A2AR+ cells were detected in spleen and lymph node sections of bo
A2AR+ cells were detected in spleen and lymph node sections of both EAMG and complete Freund's adjuvant (CFA) rats; however, A2AR+ staining in lymph node (p < 0.05) and spleen (p < 0.001) cells of rats presenting with EAMG compared with those of CFA-treated
controls had significantly reduced A2AR expression MAPK Inhibitor Library levels (Fig. 1). In addition, double-labeling experiments were performed to analyze the expression of A2AR on CD4+ T cells, CD8+ T cells, and B cells. EAMG rats presented with a significantly lower A2AR expression frequency on CD4+ T cells (p < 0.001), CD8+ T cells (p < 0.01, p < 0.05), and B cells (p < 0.05, p < 0.01) compared with CFA rats in both the lymph nodes and spleen, respectively (Fig. 2). We next determined whether selective enhancement of A2AR function could compensate for decreased A2AR expression in rats presenting with EAMG, thereby delaying disease progression. Enzyme-linked immunosorbent assays (ELISAs) were used to measure click here anti-AChR IgG production from AChR-specific lymphocytes after incubation
with (2-(p-(2-carbonylethyl)phenylethylamino)-5-N-ethylcarboxamidoadenosine) (CGS21680; a selective A2AR agonist) for 72 h in vitro. We observed that CGS21680 significantly inhibited anti-AChR IgG secretion levels in a dose-dependent manner compared with EAMG rat AChR α97-116 peptide (AChR R97-116) stimulation alone (Fig. 3A). In parallel, the B-enzyme-linked immunospot (B-ELISPOT) was used to detect the number of anti-AChR IgG antibody-secreting cells.
CGS21680 (30 nM) significantly inhibited the number of anti-AChR IgG antibody-secreting Mirabegron cells as well (p < 0.01) (Supporting Information Fig. 1), and this inhibitory effect was completely abrogated by the addition of the A2AR antagonists ZM241385 (10 nM; p < 0.05) and SCH58261 (10 nM; p < 0.05) (Fig. 3B). Also, the addition of H-89 (100 nM), a protein kinase A (PKA) inhibitor, also blocked the effects of CGS21680 (30 nM; p < 0.05) (Fig. 3B). We further determined whether A2AR-mediated inhibition occurred only during the presence of the A2AR agonist. T-cell activation was induced by AChR R97-116 stimulation in the presence or absence of CGS21680 (30 nM). CGS21680 was removed by extensive washing 24 h later and the cells restimulated with AChR R97-116 immediately after washing. Interestingly, CGS21680-pretreated cells produced a significantly reduced amount of anti-AChR IgG even after the removal of CGS21680 (p < 0.05) (Supporting Information Fig. 2). The potential regulatory activity of CGS21680 on proliferation was assessed using conventional 3H-incorporation experiments to measure proliferation in vitro. Significant differences were observed in the suppressive capacity of CGS21680 in inhibiting AChR antigen-specific lymphocyte proliferation (p < 0.05) (Fig. 4).
aro and E coli infection could elicit AMA production, but that E
aro and E. coli infection could elicit AMA production, but that E. coli was the more potent stimulus. Next we examined the livers of N. aro- and E. coli-infected mice by histological and immunohistochemical staining. Although AMA were detectable as early as 4 weeks after bacterium infection, significant pathological changes in liver were not detected before 19 weeks after either N. aro or E. coli inoculation. However, by 26 weeks following infection, striking portal inflammation accompanied by granuloma formation was present in livers of both N. aro- and E. coli-infected mice, RO4929097 solubility dmso but not in the uninfected control group. Significant
biliary cell damage was also detected in both E. coli- and N. aro-infected mice (Fig. 3). To further determine the extent of bile duct LEE011 damage, we performed immunohistochemical staining
for CK19 to visualize biliary epithelial cells among lymphoid aggregation. As shown in Fig. 4, varying degrees of biliary cell damage were found in either E. coli- or N. aro-infected mice, but not in the control mice. In both infected groups, while some bile ducts are nearly intact with mild lymphoid aggregation (blue arrows), in some portal tracts the biliary epithelial cells were completely obliterated (red arrows). These results indicate that E. coli infection is sufficient to induce cholangitis in the biliary disease-prone NOD.B6-Idd10/Idd18 mice. We have previously used an antigen-presenting cell (APC)-free assay to identify microbes that have antigens for NK T cells [38, 39]. In this assay, microwells are coated with soluble mouse CD1d molecules and incubated either with antigen Ergoloid preparations or total bacterial sonicates. The plates are then cultured with NK T cell hybridomas and interleukin (IL)-2 release, which provides a bioassay for T cell antigen receptor engagement, was quantitated. As can be seen in Fig. 5, sonicates of S. yanoikuyae, which are known to have glycosphingolipid antigens for NK T cells [40], produced IL-2 release from several NK T cell hybridomas.
By contrast, E. coli sonicates, which do not have such antigens, did not produce hybridoma IL-2 release. Although related to Sphingomonas spp., N. aro sonicates also did not produce IL-2 secretion by NK T cells. Therefore, it is unlikely that N. aro has significant quantities of a glycolipid antigen capable of activating NK T cells. Our data also indicate that exposure to N. aro does not induce cholangitis by a unique NK T activating mechanism and we suggest that previous data were probably secondary to molecular mimicry. The challenge for researchers would be to identify genetically at-risk hosts and determine the extent of other secondary factors that may also contribute, perhaps concurrently with microbial infections, to the aetiology of PBC.
Articles not in English, animal or cadaveric studies, musculocuta
Articles not in English, animal or cadaveric studies, musculocutaneous flaps, pedicled flaps, ulnar forearm free fasciocutaneous flaps used for reconstruction Romidepsin in non-head and neck regions, review articles, ulnar fascial flaps, and alternative free fasciocutaneous flaps were excluded. The three reviewers evaluated the selected articles for various parameters regarding number of ulnar flaps, flap dimensions, recipient vessels and location, donor morbidity,
need for skin grafting, complications, and rationale for use of the UFFF in comparison to other flaps, in particular the RFFF. Our searches led to 20, 24, and 36 articles; 17 of the 80 articles which met inclusion criteria (Fig. 1). Sixty-three articles were excluded either due to lack of relevance or publication in a language other than English. In addition to our case presentation, 681 cases of UFFF were identified in the selected publications[2-18]. Fifty-five percent (372 of 682) of the cases reported use of the Allen's test, with one study noting that in 23 of the 30 cases, a UFFF was specifically selected over a RFFF due Selleck GS1101 to a positive Allen's test.[9] Fifty-seven percent of the UFFF cases reviewed were reported for cancer resection reconstructions. Ninety-seven
cases (14%) were reported for intraoral reconstruction, 37 cases (5.4%) for pharyngoesophageal reconstruction, and 15 cases (2.2%) were described Tyrosine-protein kinase BLK for head and neck reconstruction external to the oropharynx. Pre-operative imaging was only noted in 51 cases, with Doppler ultrasound imaging used to determine the thickness of the subcutaneous fat layer. Flap sizes ranged from 3 to 32 cm in width and 5 to 22 cm in length. Seventy-three cases (11%) were reported as direct closures and 174 cases (26%) as skin graft closures; of note, 14 were full-thickness skin grafts, while the other 164 cases involved split-thickness skin grafts (Table 1). Of 432 cases in which flap survival was reported, 14 (3.2%) flap losses were noted including 13 (3.0%) total flap failures and one (0.2%) partial
flap failure; a pectoralis major flap reconstruction was performed after one total flap loss. Donor site morbidity reported included 10 cases of wound dehiscence or infection out of 128 cases (7.8%) reporting this specific outcome, 13 partial or total skin graft losses in 235 documented cases (5.5%), 32 cases of sensation changes in the donor site region out of 403 documented cases (7.9%), impaired wrist and finger mobility in 18 of 358 documented cases (5.0%), and grip strength loss in three of 358 documented cases (0.8%) (Table 2). A primary or replacement skin graft was performed in six cases of wounds requiring repair. In our experience and that of the authors identified in the articles, surgeon-perceived advantages served as the driving force behind UFFF use.
sigmodontis infection As
sigmodontis infection. As Dabrafenib concentration a first approach to dissect the role of the different IL-10-producing cell types in suppressing L. sigmodontis-specific Th1 and Th2 immune responses, we used mice with targeted B-cell-specific (IL-10FL/FL CD19-Cre) and CD4+ T-cell-specific (IL-10FL/FL CD4-Cre) deletion of the IL-10 gene [23, 24]. The immune response provoked by natural L. sigmodontis infection in mice lacking either T-cell-derived or B-cell-derived IL-10 was analyzed at days 17, 30, or 60 p.i. Recording L. sigmodontis
Ag-specific Th1 and Th2 responses, we observed that IL-10 deficiency in CD4+ T cells resulted in increased production of both, Th1-associated IFN-γ and Th2-associated IL-5 plus IL-13 responses to L. sigmodontis Ag at day 17 as an early time point of infection and at day 60 p.i. as a late time point of infection (Fig. 2A). Increased cytokine production was also observed upon polyclonal T-cell stimulation by anti-CD3 in CD4+ T-cell-specific IL-10−/− mice. CD19+ B cells represented a major source of L. sigmodontis-specific IL-10 during infection (Fig. 2, days 17 and 60). Interestingly, this B-cell-derived IL-10 was not mediating suppressive Torin 1 in vivo effects, since B-cell-specific IL-10 deficiency did not induce statistically significant changes in L. sigmodontis Ag-specific
cytokine responses throughout infection (Fig. 2A). Polyclonal T-cell stimulation resulted in comparable, but low proliferation in splenocytes derived from all groups at day 60 p.i. L. sigmodontis Ag-specific proliferation was detectable Carbohydrate in WT mice, while increased by trend in mice lacking IL-10 in T cells and decreased by trend in mice lacking IL-10 in B cells. However, these changes were not statistically significant (Fig. 2B). To rule out that the increased cytokine production observed in T-cell-specific IL-10−/− mice was due to changes in the cellular composition, we analyzed spleens at day 60 p.i. We did not record
significant changes in number and frequency of CD19+ B cells (Supporting Information Fig. 1A). We observed a decreased number and frequency of all T cells including CD4+Foxp3+ regulatory T cells, CD4+ T cells, and CD8+ T cells in spleens derived from T-cell-specific IL-10−/− mice (Supporting Information Fig. 1B). Therefore, increased Ag-specific proliferation and cytokine production in these mice was initiated by an even lower number of CD4+ T cells. The number and frequency of DX5+CD3− NK cells or DX5+CD3+ NKT cells were unchanged in all strains (Supporting Information Fig. 1C). Neither B-cell- nor T-cell-specific IL-10 deficiency induced statistically significant changes in the humoral response (Supporting Information Fig. 2). Taken together, our results indicate that specifically T-cell-derived IL-10 interfered with L. sigmodontis-specific Th1 and Th2 responses. B-cell-derived IL-10 was not central for initiating L.
55,56 Associations between the presence of shorter (GT)n repeats
55,56 Associations between the presence of shorter (GT)n repeats and less susceptibility to different autoimmune diseases have been reported.57,58 Consistent with this notion is the observation that patients with rheumatoid arthritis display higher ratios between longer (GT)n and shorter (GT)n repeats than do healthy patients and hence
fewer HO-1 transcripts and less protein expression.59 Therefore, although we have only observed decreased HO-1 expression in monocytes from patients with SLE, it is possible that HO-1 microsatellite polymorphisms, such as Roxadustat manufacturer (GT)n, could play a role in the expression of this enzyme. Further research is required to evaluate this hypothesis. Although our results show a decrease in HO-1 levels on monocytes from patients with SLE, we could not detect a correlation between HO-1 levels and the SLEDAI in these patients. However, we observed that all of the six patients with the highest SLEDAI displayed low levels of HO-1 in their monocytes (Fig. 4). It is possible that the lack of correlation between disease activity and HO-1 levels could be the result of the small number of patients included and that most of them did not have a very active disease. Nevertheless, the fact that HO-1 expression remains low independent
of the activity of the disease does not exclude this molecule as an interesting new therapeutic target for treating patients with SLE. Indeed, the chemical induction of HO-1 in MRL/MpJ-Faslpr (MRL/lpr) mice, an animal model of SLE, decreases the symptoms of Methisazone disease in part by a reduction Forskolin cost of nitric oxide synthase expression in the kidney and spleen and by a reduction in IFN-γ serum levels,60 supporting a potential use of HO-1 as a therapeutic target in patients with SLE. We would like to thank Dr Aquiles Jara and Sandra Vilches for providing blood samples from kidney-transplanted patients
and to Ana Karina Jimenez for kindly coordinating the clinical visits and laboratory work of patients with SLE and healthy subjects. We also thank the generous collaboration of all the patients with SLE who participated in this study. This work was supported by grants from FONDECYT 1085281, 1070352, 1110518, 3070018, ECOS-CONICYT C07S01, Biomedical Research Consortium and Millennium Institute on Immunology and Immunotherapy P04/030-F, IMBIO programme, l'Agence de la Biomédecine, Ministère de la Recherche, Fondation CENTAURE, Fondation Progreffe. AAH is a CONICYT fellow and AMK is a Chaire De La Région Pays De La Loire De Chercheur Étranger D'excellence. A patent application for the use of CO and HO-1 modulation to treat SLE has been submitted. Figure S1. Normal levels of HO-1 on monocyte-derived DCs from SLE patients. Figure S2. Surface HO-1 expression in monocytes, lymphocytes and DCs from SLE patients. Figure S3. Expression of MHCII and CD86 in monocytes from SLE patients. Figure S4. Reduced HO-1 expression in monocytes and dendritic cells from RA patients. Figure S5.
30972714; 81030054); and the Key Project of the Natural Science F
30972714; 81030054); and the Key Project of the Natural Science Foundation of Jiangsu Province, China (No. BK2007730). "
"Human β defensin-3 (hBD-3) is an antimicrobial peptide with diverse functionality. We investigated the capacity Selleckchem Decitabine of hBD-3 and, for comparison, Pam3CSK4 and LL-37 to induce co-stimulatory molecules and chemokine expression in monocytes. These stimuli differentially induced CD80 and
CD86 on the surface of monocytes and each stimulant induced a variety of chemokines including monocyte chemoattractant protein 1 (MCP-1), Gro-α, macrophage-derived chemokine (MDC) and macrophage inflammatory protein 1β (MIP1β), while only hBD-3 and Pam3CSK4 significantly induced the angiogenesis factor, vascular endothelial growth factor (VEGF). Human BD-3 induced similar chemokines in monocyte-derived macrophages and additionally induced expression of Regulated upon activation normal T-cell expressed and presumably secreted (RANTES) in these cells. Comparison of monocytes from HIV+ and HIV–
donors indicated that monocytes from HIV+ donors were more likely to spontaneously express certain chemokines (MIP-1α, MIP-1β and MCP-1) and less able to increase expression of other molecules in response to hBD-3 (MDC, Gro-α and VEGF). Chemokine receptor expression (CCR5, CCR2 and CXCR2) was relatively normal in monocytes from HIV+ donors compared with cells from HIV– donors with the exception of diminished expression of the receptor for MDC, CCR4, which was reduced in the patrolling monocyte subset (CD14+ CD16++) of HIV+ donors. These observations implicate chemokine Selleckchem 5-Fluoracil induction by hBD-3 as a potentially important mechanism for orchestrating cell migration into inflamed tissues. Alterations in chemokine production or their receptors in monocytes of HIV-infected persons could influence cell migration and modify the effects of hBD-3 at sites of inflammation. Human β defensin-3 (hBD-3) is an inducible antimicrobial peptide that
is produced by epithelial cells. This molecule mediates the killing of microbes,[1] chemotaxis of CCR2+ cells such as monocytes[2] and activation of antigen-presenting cells (monocytes and myeloid dendritic cells[3, Thiamet G 4]). These diverse functions indicate that hBD-3 could play an important role in both innate and adaptive defences. Increased expression of hBD-3 is observed in inflammatory microenvironments including psoriasis and oral carcinoma.[1, 5] Because monocytes are chemoattracted by hBD-3[5, 6] and can potentially migrate into inflamed tissues,[7] it is important to consider the functional effects of hBD-3 on these cells. Our previous studies identified Toll-like receptor 1/2 (TLR1/2) -dependent signalling as a mechanism by which hBD-3 could cause activation of these cells.[3] Human BD-3-mediated activation of monocytes induced expression of co-stimulatory molecules (CD80 and CD86) as well as expression of various cytokines including interleukin-6 (IL-6), IL-1β and IL-8.
At the same time,
existence of vascular access complicati
existence of vascular access complications during follow-up was evaluated. Results: Increases in PTX3 and hsCRP were not significantly correlated with each other. By multivariable regression models, we found increase of PTX3 is positively correlated to the increases of ADMA (P < 0.001) and oxidized LDL (P < 0.05). Furthermore, none of three patients with high PTX3 (≥10 ng/mL) but all three patients with high hsCRP (≥0.9 mg/dL) developed GSK2126458 purchase vascular access complications during the study. Conclusion: We suggested that, unlike hsCRP, the production of PTX3 is strongly positively correlated with oxidative stress and protects from vascular access complications in a 1-year HD cohort. HA PHAN HAI AN1,2, NGUYEN MANH TUONG2, NGUYEN THE CUONG2, TRAN MINH TUAN2, NGUYEN THI THUY2 1Hanoi ABT-263 molecular weight Medical University, Hanoi, Vietnam; 2Viet Duc University Hospital, Hanoi, Vietnam Introduction: Hepatitis C infection is a common transmissible disease in the world and in Vietnam. This condition can result in severe consequnces such as chronic hepatitis, liver cirrhosis, and liver cancer. The major route of transmission is through blood and blood products. Hemodialysis is a favorable factor for disease transmission due to frequent exposure to blood. Hepatitis C infection is a big challenge for patients receiving maintenance hemodialysis in Vietnam,
it increases the burden, prevalence of complications, and mortality among them.
The aim of this study was to assess the effectiveness of modified priming protocol on Hepatitis C infection rate among patients on maintenance hemodialysis (MHD). Methods: Clinical interventional trial and retrospective study conducted on all adult patients receiving MHD at Dialysis and Kidney Disease Department, Viet Duc Hospital, Hanoi, Vietnam from Jan 2007 to Dec 2012. Data collected during 2 periods using 2 different priming protocols: classical protocol from 2007–2009, modified protocol from 2010–2012. Results: Prevalent rate of HCV infection among patients receiving MHD period 2007–2012 was 32.5%. During this period of observation, the annual prevalent rate did not change significantly, it was 38.2%, 36.0%, 35.3%, 32.7%, 29.1% and 28.5% for year 2007, Loperamide 2008, 2009, 2010, 2011, and 2012 respectively. The prevalent rate of HCV in period 2007–2009 did not differ from that of period 2010–2012 (39.6% vs 36.2%, p > 0.05). However, there was a significant reduction of incident rate of HCV infection from 14.0% during period 2007–2009 to 0.9% during period 2010–2012. This reduction was also observed in a group of high risk patients who receive treatment for more than 4 years and reuse HD consumables (10.9% vs 1.8%, p < 0.05). Conclusion: Prevalent rate of HCV infection remained very high during study period but modified priming protocol had positive impact on incident rate of infection.
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Pla Signaling


text:
Sorbets ist eine französische Gemeinde mit  Einwohnern (Stand: ) im Département Landes in der Region Nouvelle-Aquitaine. Sie gehört zum Arrondissement Mont-de-Marsan und zum Kanton Chalosse Tursan.

Sie grenzt im Nordwesten an Pécorade, im Norden an Bahus-Soubiran, im Nordosten an Aire-sur-l'Adour, im Osten an Latrille, im Südosten an Miramont-Sensacq, im Süden an Mauries und im Westen an Geaune. An der östlichen Gemeindegrenze verläuft der Fluss Lourden, ein Nebenfluss des Adour.

Bevölkerungsentwicklung

Weblinks

Ort in Nouvelle-Aquitaine

redpajama_set_name: RedPajamaWikipedia


text:
Greatest Viking Of All Time Tournament
Greatest Viking Of All Time Tournament: (1) Cris Carter vs (2) Alan Page
By Christopher Gates Aug 20, 2013, 8:00am CDT
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One of the two Final Four match-ups in our Greatest Viking Of All Time Tournament is in the books, ladies and gentlemen, and now it's time to bring you the other one. The tournament's last remaining defender will attempt to bulldoze his way into the Championship Match, and to do so he will have to get past the Vikings' most recent Hall of Fame inductee.
Alma Mater: The. . .dramatic pause. . .Ohio State University
Acquired by Minnesota: Acquired on waivers prior to the 1990 season
Seasons in Minnesota: 12 (1990-2001)
Position: Wide receiver
How He Got Here: Defeated John Sullivan 137-7 in Round 1; Defeated Matt Blair 217-17 in Round 2; Defeated Paul Krause 115-99 in Round 3; Defeated Jim Marshall 136-125 in Round 4
Cris Carter turned his life around as a member of the Minnesota Vikings after getting cut by the Philadelphia Eagles after three seasons in the National Football League. They gave him a chance, and he rewarded the team by becoming not only the greatest wide receiver in the history of the Minnesota Vikings, but one of the greatest wide receivers the National Football League has ever known. While his career stats put him into the Top Ten in the three major receiving categories in NFL history, if you took just his numbers from his time in Minnesota, his 1,024 receptions would put him eighth on the list, his 12,383 yards as a Viking would put him 17th, and he would be sixth all-time in receptions with 110. Carter finally got his due, being inducted into the Pro Football Hall of Fame a few weeks ago, and is truly one of the greats of the game.
Alma Mater: University of Notre Dame
Acquired by Vikings: Round 1, 1967 NFL Draft
Position: Defensive Tackle
How He Got Here: Defeated Tony Dungy 162-6 in Round 1; Defeated Mick Tingelhoff 166-10 in Round 2; Defeated Randall McDaniel 167-47 in Round 3; Defeated Fran Tarkenton 140-101 in Round 4
Of all the great defensive linemen that have taken the field as members of the Minnesota Vikings, Alan Page might be the greatest of them all. The fifteenth pick in the 1967 National Football League draft had an incredible career as one of the famed Purple People Eaters. He was the first defensive player in the history of the National Football League to be named Most Valuable Player in 1971, and was also the league's Defensive Player of the Year in 1971 and 1973. The "unofficial" totals. . .as sacks were not an official stat while Page was a player. . .show him with 108.5 sacks as a Viking. On top of that, he also blocked 28 kicks in his career. His number 88 is one of only six that have been retired by the Minnesota Vikings, never to be worn again. One of the true titans of Minnesota Vikings history, Alan Page is well-deserving of his spot in our Final Four.
The interview actually stops at about the 7:30 mark. . .but man, does that voice sound familiar.
If you need a primer on how the voting for our contest works, we have one for you at this link here. Remember, rec the comments to register your vote. Putting "Vote - Name" in the subject line of a post does not count.
If you want to vote for Cris Carter, rec the comment that says "Vote - Cris Carter"
If you want to vote for Alan Page, rec the comment that says "Vote - Alan Page"
Also, in light of what happened in our first Elite 8 match-up, please do not reply to either of the first two comments in the thread. Those comments need to remain together and not have one get pushed down the comments section.
Voting is open for 24 hours, just like always, folks. Have at it!
Daily Norseman's Greatest Viking Of All Time Tournament
Greatest Viking: Final Bracket
Greatest Viking: (1) Carter vs (2) Page
Greatest Viking: (1) Peterson vs (1) Grant
Justin Jefferson sends Minnesota veteran to the Super Bowl Because he's awesome, that's why
Minnesota Vikings News and Links, 31 January 2023 Stop by, pull up a chair, and talk about your favorite team!

redpajama_set_name: RedPajamaCommonCrawl


The annual American military budget, the 2017 National Defence Authorization Act (NDAA), incorporated a provision for this in a section titled, "Enhancing defence and security cooperation with India".
It was earlier passed by House of Representatives by 375-34 votes, and now by the Senate by 92-7 votes.
After 180 days of passing the bill, the US secretary of defence and secretary of state will submit Congress a report on how the US is supporting its defence relationship with India.
'Enhancing defence and security cooperation with India' forms the Section 1292 of the NDAA bill.
This asks the defence secretary and the secretary of the state to take required steps to recognize India as America's major defence partner.
It further asks the administration to assign an individual from the executive branch to ensure the success of the Framework for the US-India Defence Relationship.
What does the recognition mean for India?
The major defence partner status means that India can now get access to 99% of the American defence technologies as the "export hurdle of high tech US military hardware and technology to India" is done away with.
The act also seeks collaboration with India to develop mutually agreeable mechanisms to verify the security of defence articles, services and related technology.
Provisions like the defence partnership status for India are usually embedded into budget bills as they would have the effects of the law and can be adopted faster without having to go through full legislative process which involves lengthy reviews and debates.
Two bills, the US-India Defense Technology and Partnership Act, and the Advancing US-India Defence Cooperation Act are currently stuck in legislative process.


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Гермилсилан — неорганическое соединение,
германопроизводное дисилана (или кремниевое производное дигермана) с формулой HSiGeH,
бесцветный газ,
самовоспламеняется на воздухе.

Получение
 Реакция силилкалия и хлоргермана:

 продукты реакции очищают фракционной перегонкой в низкотемпературной колонке (-112°С) от SiH и GeH.

 Действие слабым электрическим разрядом на смесь моносилана и германа с последующим разделением продуктов реакций фракционной перегонкой.

Физические свойства
Гермилсилан образует бесцветный газ,
который самовоспламеняется на воздухе.

Химические свойства
 Разлагается при нагревании:

Литература

Германы


text:
OUT OF MIND » THE INSANITY OF REALITY » GLOBAL FINANCIAL COLLAPSE » Morgan Commodity Chief Blythe Masters leaves the sinking ship 0
Morgan Commodity Chief Blythe Masters leaves the sinking ship 0
1 Morgan Commodity Chief Blythe Masters leaves the sinking ship 0 Thu Apr 03, 2014 12:38 pm
Morgan Commodity Chief Blythe Masters leaves the sinking ship
blythe masters, commodities, finance, gold, jp morgan, jpm, manipulation, silver
by Clark Kent
A week ago we wrote: 'While it has been public for a long time that i) JPM is eager to sell its physical commodities business and ii) the most likely buyer was little known Swiss-based Mercuria, there was nothing definitive released by JPM. Until moments ago, when Jamie Dimon formally announced that JPM is officially parting ways with the physical commodities business. But while contrary to previous expectations, following the sale JPM will still provide commercial gold vaulting operations around the world, it almost certainly means farewell to Blythe Masters." Sure enough:
JP MORGAN COMMODITY CHIEF BLYTHE MASTERS LEAVING, WSJ SAYS
MASTERS DEPARTURE DISCLOSED IN JPMORGAN MEMO
MASTERS TO `CONSIDER FUTURE OPPORTUNITIES,' ACCORDING TO MEMO
MASTERS TO HELP JPMORGAN WITH COMPLETION OF MERCURIA DEAL: MEMO
Farewell Blythe: we hope your replacement will be just as skilled in keeping the price of physical gold affordable for those of us who keep BTFD every single day.
And since it is nostalgia day, here is, from April 2012, "Blythe Masters On The Blogosphere, Silver Manipulation, Gold-Axed Clients And Doing The "Wrong" Thing"
In an article that is about three years overdue, "JPMorgan's practices bring scrutiny" the FT finally takes aim at that other "vampire squid", JP Morgan, which technically is incorrect: because if Goldman is a nimble and aggressive creature, with infinite tentacles in every governmental office, and unencumbered by massive liabilities, JPMorgan is just as connected, but unlike Goldman, it is a behemoth in every other possible capacity, and with its trillion in deposits, matched by tens of billions in bad loans, is a true Bank Holding Company. As such 'Jabba the Hutt' would be a far more appropriate allegory to describe the the firm, whose reach, scope and scale lead the FT to classify it as "Three times a pallbearer, never a corpse."
As some may recall, back in October 2009, Zero Hedge did an exhaustive expose on the relationship between JPMorgan and the then version of MF Global, Lehman Brothers, whose perfectly functioning division, its North American Brokerage, ended up being scooped up by Barclays for pennies on the dollar. In the meantime, however, JPMorgan, with the backing of the Fed, proceeded to demand as much extra collateral for Lehman repo positions on hold with JP Morgan and the Tri-Party repo system, of which JPM is one of only two custodians, simply because it could, and because this is the easiest way for the bank that is even closer to the Fed than Goldman Sachs, to procure liquidity during times of broad distress. Such as when the money market is about to freeze to death. Since then, the topic of just how much JPMorgan may have ripped off the Lehman estate has escalated, and is set to be an epic showdown in the form of a lawsuit which "accuses JPMorgan of using its "life and death power as the brokerage firm's primary clearing bank" to put a "financial gun" to its head and demand excess collateral." And here is the kicker: "It claims JPMorgan abused its access to US government officials and then "accelerated Lehman's free fall into bankruptcy", hoovering up collateral to protect itself to the detriment of the firm and other eventual creditors."
And therein lies the rub: because of all TBTF banks, JPMorgan is literally at the nexus of the entire $16 trillion shadow banking system, the very system that the Fed, much more than traditional liabilities, knows and uses constantly to hypothecate and rehypothecate assets, in essence creating money out of nothing, and which in conjunction with the other Tri-Party repo dealer, Bank of New York, as well as State Street, provides the US financial system with over $30 trillion in shadow credit money in the form of custodial assets – liquidity the bulk of which is not accounted for in any conventional monetary textbook or in any modern theory of money as it is such a novel development, yet which is still 100% fungible, and is by far the biggest secret of the American monetary system. It can be seen as summarized in the following graphic, first created by Citi's Matt King back in the week before Lehman failed (full report can be read here, and should be by anyone who wishes to understand just what is truly going on behind the scenes in modern finance).
Keep in mind, these are the same custody assets which, as explained previously in the case of MF Global, can be rehypothecated in serial fashion, creating a virtually infinite amount of "money" as long as everyone who is in on the fraud agrees to maintain the ponzi. Of course, if and when someone demands delivery of an underlying assets, the whole thing falls apart, which is what happened with AIG, with Lehman, and to a smaller degree, MF Global.
So what does all of this have to do with Blythe Masters?
At the end of the day, and as the Lehman lawsuit alleges, JPMorgan has intimate access to US government officials, and particularly the Federal Reserve, who will in turn take advantage of all JPM facilities, including its trading desk, to preserve the sanctity and foundations of the $30+ trillion in custodial assets and rehypothecation system, which further means that any potential implication that fiat money is impaired has to be wiped out. As it so happens, soaring prices of gold and silver are the primary if not only means left to express rising doubts in the future viability of the dollar, but in the viability of the fiat system in the first place. Which means that the Fed is, without a doubt, one of the biggest "clients" of the Fed in a symbiotic crosshold, where what the Fed wants, JPM has to execute and vice versa.
This brings us to the transcript of Blythe's interview on CNBC, in which a primary topic, ironically, was whether or not Jamie Dimon's firm manipulates the prices of precious metals, and particularly silver. What followed was the usual avalanche of platitudes that only a muppet can love:
"JPM's commodities business is not about betting on commodity prices but about assisting clients"… "it's about assisting clients in executing, managing, their risks and ensuring access to capital so they can make the kind of large long-term investments that are needed in the long run to expand the supply of commodities"…
"There's been a tremendous amount of speculation particularly in the blogosphere on this topic. I think the challenge is it represents a misunderstanding as the nature of our business. As i mentioned earlier, our business is a client-driven business where we execute on behalf of clients to achieve their financial and risk management objectives. The challenge is that commentators don't see that. So to give you a specific example, we store significant amount of commodities, for example, silver, on behalf of customers we operate vaults in New York City, Singapore and in London. And often when customers have that metal stored in our facilities, they hedge it on a forward basis through JPMorgan who in turn hedges itself in the commodity markets. If you see only the hedges and our activity in the futures market, but you aren't aware of the underlying client position that we're hedging, that would suggest inaccurately that we're running a large directional position. In fact that's not the case at all.
"We have offsetting positions. We have no stake in whether prices rise or decline. Rather we're running a flat or relatively flat matched book.
"What is commonly out there is that JPMorgan is manipulating the metals market.It's not part of our business model. it would be wrong and we don't do it."
Ah yes, because JPMorgan never engages in "wrong" activites…
And while we admire JPM's naive statement that it can triple its commodities revenues to $2.8 billion in 2011, while everyone else was losing money in the space, without taking prop bets, we just don't buy it. Just as we didn't buy Goldman's explanation that its prop desk only accounted for 12% of that firm's revenue, as Goldman told us directly (coupled with our challenge of prop trading in 2009, a pursuit taken on by Paul Volcker a few weeks later, resulting in the Volcker Rule). Needless to say, once the firm did break out its prop trading, it became quite clear just how huge of a factor prop trading truly was for Goldman. Because taken at face value, it would mean that all else equal, JPMorgan transacted at least 3 times more in flow in 2011 than in 2010. Yet, everyone knows that trading volumes in 2011 slumped relative to 2010. So no, Blythe, we appreciate your explanation, but we would appreciate the truth even more.
And yet there is one simple explanation that would make Blythe's story 100% correct: would JPMorgan consider the Fed, whose interests in keeping the price of precious metals as low as possible, and are aligned with those of JPM for the reasons listed above, its client?
Because if so, then absolutely everything falls into place, as JPMorgan is merely the overt conduit by which the Fed, and specifically the New York Fed, conducts monetary policy in the commodities space, just as Brian Sack would conduct open market operations in the bond arena, and as the FRBNY uses, on occasion, Citadel, and its HFT expertise, to execute its discretionary stock trades (yes, we know about those too).
We would welcome Blythe's comments on any and all of the topics listed above.
In the meantime, for those who missed it, here's Blythe.
Thanks to: http://www.hangthebankers.com
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Media Movers is proud to launch the new eco-media digipacks. Exclusively designed and the very latest in environmentally friendly CD/DVD packaging, the eco-media digipacks are the most recent move in our pursuit to develop premium, cost-effective, eco-friendly products, as markets continue to search for alternatives.
Sourcing from sustainable forests – Printed board is either recycled or sourced from sustainable forests.
The packs maintain the premium look and feel that Media Movers has brought to the market through digipacks, however now we bring the most advanced eco-friendly pack to this market.


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Durham Beat is an arts & culture publication practicing in the style of Gonzo Journalism.
DURHAM BEAT MAGAZINE
Published quarterly, each issue of our magazine is dedicated to a focused examination of one broad cultural topic, which we explore in-depth and in collaboration with an artist working in that field. With every issue of our magazine, we create a limited run t-shirt designed by the featured artist. Profits from the shirt are split with that artist. While it's nice to be featured in an art magazine, we want our approach to magazines to be something more: a direct source of income for the artists with whom we collaborate. We believe in the economic enfranchisement of artists and our business model reflects this at every level.
You can subscribe to Durham Beat Magazine on Patreon:
Our subscriptions via Patreon include additional behind the scenes access to us and the work we do, as well as Patron-only content.
1. Membership Subscription: includes all issues of the magazine as they publish + free shipping + access to our Close Friends List on Instagram, and other Patron-only content.
2. Insider Subscription: includes all benefits of Membership + all Limited Run Collaboration Issue t-shirts in the size of your choosing.
DURHAM BEAT ONLINE
Our website functions as an online publication where we publish reviews, reactions, thoughts, and other musings about creative endeavors in our area, whether that's music, beer, theatre, visual art, shows, or anything else that enlivens the lives of locals.
THE BEAT MARKET & OTHER EVENTS
In addition to our magazines and shirts, we also curate and host a monthly art market called The Beat Market with our friends at Fullsteam Brewery in Durham. Our market offers free vending space for artists and guaranteed pay for performing musicians. We also occasionally host shows, dance parties, and interactive live art events at venues and off-beat locations around Durham and the Triangle area.
Artists & Vendors interested in signing up for The Beat Market may do so HERE.
We believe that to tell a story of excellent quality and deepest connectivity with an audience, you have to be willing to get involved, to be vulnerable, and to fundamentally engage with the community. A community is not just a city and the people living in it. A community is a coming together of people who share a desire to feel connected to each other and the world around them. For us, that sense of community is driven by the experience of art and culture. We believe that art is a fundamental part of human life and plays an essential role in human society. We want to share in all of this with you. This is the mindset that lives at the heart of everything we do. We are grateful for your support, your readership, and your community spirit. Thank you for being here.
Learn more about the artists who contribute to Durham Beat on The STAFF PAGE.
If you would like to reach us, then please write to us on email at editor@durhambeat.com.


Port Manteaux Word Maker OneLook. 2017 11 21 183; Port Manteaux churns out silly new words when you feed it an idea or two. Enter a word (or two) above and you'll get back a bunch of portmanteaux created by jamming together words that are conceptually related to your inputs.
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They are rubbish! People in the store really not professional. Jamie (their agent) have taken my money for a pre-order and disappeared. No explanation. Only an email saying "sorry for any inconvenience caused". Not answering to any call now. Really unpleasant. Don't give them your time and you money!!!!


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redpajama_set_name: RedPajamaGithub


Leeds Climathon: How can we deliver domestic carbon reduction in an age of austerity?
In Leeds the Climate-KIC Climathon will begin on the morning of the 28 October GMT and finish on the following day. It is organised by the Priestley International Centre for Climate and Centre for Climate Change Economics and Policy (CCCEP) to create new solutions which will reduce domestic carbon in the city of Leeds.
Innovative new business models are needed to ensure energy efficiency fulfils its potential to create carbon savings and cost savings for the city of Leeds. A third of Leeds' carbon emissions are due to domestic energy consumption, which contributes substantially to GDP loss to the city. Although Leeds City Council has been successful in attracting funding for efficiency measures in the past, recent national policy changes mean these are no longer cost effective. We want people from a wide range of backgrounds to join the Leeds Climathon and come up with alternative ways of approaching and, crucially, financing this.
One option is the potential of a revolving fund, which captures and reinvests savings, specifically: finance sources for it; durability, versatility and attractiveness of design; its appeal to landlords and property owners and how it can fund the more expensive measures required by older homes. Other options include new initiatives to maximise householder participation in existing low cost solutions and novel solutions for improving energy efficiency, especially in the private rented sector.
Whatever your approach to this challenge, we want to hear from people with imagination, flair, experience and skills up for a mind-melding 24 hours of teamwork to catalyse domestic carbon reduction across the city.
The Priestley International Centre for Climate is unique in bringing together world leading expertise in all the key strands of climate change research.
Climate change and its impact on society and ecosystems is a global challenge and the centre aims to provide international solutions to the problems. Effective policy and solutions need to be underpinned by robust research and the Priestley Centre's focus is on new interdisciplinary research partnerships that better link our physical, technological, economic and social understanding of climate change with strategies for mitigation and adaptation.
The ESRC Centre for Climate Change Economics and Policy (CCCEP) brings together some of the world's leading researchers on climate change economics and policy, from many different disciplines. It was established in 2008 and its first phase ended on 30 September 2013. Its second phase commenced on 1 October 2013.


A long studied and viewed Denali National Park wolf pack is on the verge of disappearing. The East Fork pack ranges near the park entrance, including on state land wolf advocates want closed to harvest. The fate of the East Fork pack has also inspired a call for closer pack monitoring and rescue of any orphan pups.
The last known adult male of the East Fork Pack was observed from the air to be dead at a hunting camp on state land outside the park's northeast boundary in early May. Park natural resources team leader Dave Schirokauer said the pack's other known remaining member, a pregnant female, denned nearby.
Schirokauer said the wolf den will continue to be monitored for activity from the air, but the chances of a mother and pups surviving alone are slim. The East Fork Pack has been studied for decades and used to be popularly viewed by park visitors.
Denali wolf advocate Rick Steiner said the current situation follows loss of an East Fork pack breeding pair to harvest in the same area last year. The pack's decline is part of a more general dip in Denali's wolf population, that's inspired unsuccessful efforts by Steiner and environmental groups to get the state to close the land east of the park along the Stampede Road to wolf killing.
Aside from the broader debate about whether or not to protect Denali wolves on state land, Steiner is pushing for on the ground monitoring of the East Fork pack, and taking any orphaned pups into captivity. The Park Service's Schirokauer said the agency favors letting nature take its course, noting even if it wanted to act, it doesn't have jurisdiction.
"Given that the den is on state land, it's really up to the state if there's any sort of human intervention," Schirokauer said.
Alaska Department of Fish and Game regional wildlife supervisor Darren Bruning does not rule out the possibility of taking orphaned wolf pups into captivity, but said it needs to be clear the pups are alone.
Bruning noted 2 situations in recent in which clearly orphaned wolf pups were removed from the wild and given to care facilities or zoos. He said the state is not actively monitoring the Denali East Fork Pack den, but is getting regular updates from the National Park Service. The Park's Schirokauer said a single pup was observed during a June 17th overflight of the den area.


Thanks for your anser. the drive is working on other computers. Hello, Thanks for your anser. the drive is working on other computers.
Windows likes Fat32 for USB drives and has trouble with Linux and Mac. Windows likes Fat32 for USB drives and has trouble with Linux and Mac.
The icon will be called safely remove hardware.
B.Go to the "My Computer" section of your computer. In there you will find a section called "devices with removable storage"
D.Locate the music stored on your computer. Generally this is stored in the "My Music" folder of your computer.
E.Once you have located the song files, you can right click on the song itself, and select "copy".
F.Open the removable disk drive, right click on in the empty space, and select Paste.
I hope this has been helpful, unfortunately without more information I cannot help any further.
The CD may have been inserted loosely in the tray and shifted inside the notebook during transit or use.
You can often remove the drive by locating a screw on the bottom of the notebook about 4-5 inches along the interior and generally near the vertical center of the Optical Drive's dimensions. Once located, remove the screw and use a small flat screwdriver or nimble fingers to remove the drive. If you encounter even moderate resistance, stop attempting to remove it and ensure the proper control screw has been removed to allow you to slide out the drive.
A second option in this scenario is to remove the flat or contoured bezel covering the Optical Drive fascia. After doing so, locate a pin-sized hole (sometimes labeled EE or with an asterisk) along the face and push it in using a small flat or Torx-based screwdriver, a pen tip, or an unbent paper clip. This will emergency eject (EE)the optical drive tray, allowing careful access to the interior and the lost media likely still inside it.
If you are convinced your media is inside the notebook and these solutions fail to assist locating it, the notebook may need much more extended disassembly to resolve this problem.
I recently ran Norton AntiVirus and it found 'suspicious.mystic' on my drive but was unable to fix or remove the program. Is there a way to remove this program and how do i locate the program file?
download thsi software program -- it works great !
www.malwarebytes.org it will get rid of it no problem.


Melt the wax and mix with some wax colorant to make this adorable candle.
Candles don't have secrets from us. Some modern inspiration are Modern Geometric Candles, some in natural styles are Beeswax Candle and some are funny like the Crayons Color Block Candle. Today We have something as good as the previous ones but a little bit girlier. Jen from 'Something Turquoise' is real candle addict. She made a candle for every single lady in her family, around 45 candles in total! What We can say, Girl has experience! Using her step-by-step instructions it won't be possible to go wrong.
Have you ever made a homemade candle? What is your favorite candle style? Share your opinion with us in the comment below!


Pagination lix, 164 p. : ill. ; 23 cm.
Description This 1903 reprint of the First annual report and collections of the State Historical Society, of Wisconsin, for the year 1854, vol. 1, includes the following articles: Lyman Copeland Draper, a memoir, by R.G. Thwaites; Early records of the Society, 1849-54, by Charles Lord and John W. Hunt; Green Bay in 1826; Lieut. James Gorrell's journal; Recollections of Green Bay in 1816-17, by James W. Biddle; Recollections of a tour through Wisconsin in 1832, by Charles Whittlesey; Legend of the Winnebagoes, by Pliny Warriner in an interview with R.W. Haskins; Early times in Wisconsin, by H.A. Tenney; Sketch of Calumet County, by Thomas Cammuck; Sketch of Richland County, by Ira S. Haseltine; Wisconsin geographical names, by Alfred Brunson; Indian names, by Joshua Hathaway; Indian nomenclature and the Chippewa, by Hiram Calkins; and Reminiscences of Wisconsin, by Alexander F. Pratt. The original 1855 edition was edited by Lyman Copeland Draper. The 1903 reprint was issued under the editorial direction of Reuben Gold Thwaites.


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Anthony Mann (born Emil Anton Bundsmann; June 30, 1906 – April 29, 1967) was an American film director and stage actor.

Mann initially started as a theatre actor appearing in numerous stage productions. In 1937, he moved to Hollywood where he worked as a talent scout and casting director. He then became an assistant director, most notably working for Preston Sturges. His directorial debut was Dr. Broadway (1942). He directed several feature films for numerous production companies, including RKO Pictures, Eagle-Lion Films, Universal Pictures, and Metro-Goldwyn-Mayer. His first major success was T-Men (1947), garnering notable recognition for producing several films in the film noir genre through modest budgets and short shooting schedules. As a director, he often collaborated with cinematographer John Alton.

During the 1950s, Mann shifted to directing Western films starring several major stars of the era, including James Stewart. He directed Stewart in eight films such as Winchester '73 (1950), The Naked Spur (1953), and The Man from Laramie (1955). While successful in the United States, these films became appreciated and studied among French film critics, several of whom would become influential with the French New Wave. In 1955, Jacques Rivette hailed Mann as "one of the four great directors of postwar Hollywood". The other three were Nicholas Ray, Richard Brooks, and Robert Aldrich.

By the 1960s, Mann turned to large-scale filmmaking, directing the medieval epic El Cid (1961), starring Charlton Heston and Sophia Loren, and The Fall of the Roman Empire (1964). Both films were produced by Samuel Bronston. Mann then directed the war film The Heroes of Telemark (1965) and the spy thriller A Dandy in Aspic (1968). In 1967, Mann died from a heart attack in Berlin before he had finished the latter film; its star Laurence Harvey completed the film albeit uncredited.

Early life
Mann was born Emil Anton Bundsmann in San Diego, California. His father, Emile Theodore Bundsmann, an academic, was born in the village of Rosice, Chrudim, Bohemia to a Sudeten-German Catholic family. His mother, Bertha Weichselbaum, a drama teacher, was an American of Bavarian Jewish descent. At the time of his birth, Mann's parents were members of the Theosophical Society community of Lomaland in San Diego County.

When Mann was three, his parents moved to his father's native country Austria to seek treatment for his father's ill health, leaving Mann behind in Lomaland. Mann's mother did not return for him until he was fourteen, and only then at the urging of a cousin who had paid him a visit and was worried about his treatment and situation at Lomaland. In 1917, Mann's family relocated to New York where he developed a penchant for acting. This was reinforced with Mann's participation in the Young Men's Hebrew Association. He continued to act in school productions, studying at East Orange Grammar and Newark's Central High School. At the latter school, he portrayed the title role in Alcestis; one of his friends and classmates was future Hollywood studio executive Dore Schary. After his father's death in 1923, Mann dropped out during his senior year to help with the family's finances.

Career

Theater career (1925–1937)
Back in New York, Mann took a job as a night watchman for Westinghouse Electric, which enabled him to look for stage work during the day. Within a few months, Mann was working full-time at the Triangle Theater in Greenwich Village. Using the name "Anton Bundsmann", he appeared as an actor in The Dybbuk (1925) with an English translation by Henry Alsberg, The Little Clay Cart (1926), and The Squall (1926) by Jean Bart. Towards the end of the decade, Mann appeared in the Broadway productions of The Blue Peter and Uncle Vanya (1929).

In 1930, Mann joined the Theatre Guild, as a production manager and eventually as a director. Nevertheless, he continued to act, appearing in The Streets of New York, or Poverty is No Crime (1931), and The Bride the Sun Shines On (1933) portraying the "Duke of Calcavalle". In 1933, Mann directed a stage adaptation of Christopher Morley's Thunder on the Left, which was performed at the Maxine Elliott's Theatre. In a theatre review for The New York Times, Brooks Atkinson dismissed the play, writing "its medley of realism and fantasy grows less intelligible scene by scene, and some of the acting is disenchantingly profane." He later directed Cherokee Night (1936), So Proudly We Hail (1936), and The Big Blow (1938). He worked for various stock companies, and in 1934, he established his own, which later became Long Island's Red Barn Playhouse.

Move to Hollywood and television career (1937–1941)
In 1937, Mann began working for Selznick International Pictures as a talent scout and casting director. He also directed screen tests for a number of films, including The Adventures of Tom Sawyer (1938), Intermezzo (1939), Gone with the Wind (1939), and Rebecca (1940). One of the unknown actresses he tested was Jennifer Jones. After a few months at Selznick, Mann moved to Paramount Pictures to serve as an assistant director for several film directors, most particularly for Preston Sturges on Sullivan's Travels (1941). Mann recalled, "[Preston] let me go through the entire production, watching him direct – and I directed a little. I'd stage a scene and he'd tell me how lousy it was. Then I watched the editing and I was able gradually to build up knowledge. Preston insisted I make a film as soon as possible." He served three years in the position.

Meanwhile, Mann did notable, but mostly lost, work as a director for NBC's experimental television station W2XBS from 1939 to 1940. This included condensations of the hit Western play The Missouri Legend and the melodrama The Streets of New York. A five-minute silent clip of the latter show survives in the Museum of Television and Radio, including noted actors Norman Lloyd and George Coulouris.

Move to directing (1942–1946)
Through the efforts of his friend MacDonald Carey, Mann made his directorial debut with Dr. Broadway (1942) at Paramount, which starred Carey. Decades later, Mann remembered he was told to complete shooting the film in eighteen days. Upon its release, Herman Schoenfeld of Variety was dismissive of the film writing, "The dialog could have just as well have been written in baby talk, and Anton Mann's direction just wasn't. The photography is spotty and the production looks inexpensive. Acting is weak, only Edward Ciannelli as the killer who gets killed, turning in an adequate job." Harrison's Reports was more complimentary, stating the film was a "fairly good program entertainment" with "colorful characters, human interest, fast action, and situations that hold one in suspense."

His follow-up film was Moonlight in Havana (1943) at Universal Pictures. The film featured Allan Jones and Jane Frazee. In August 1944, it was reported Mann might return to Broadway to direct Mirror for Children. After nine months without directing a feature film, Mann went to Republic Pictures where he directed Nobody's Darling (1944) and My Best Gal (1944).

He next directed Strangers in the Night (1944). The film tells of Hilda Blake (Helene Thimig) who creates an imaginary "daughter" for Sgt. Johnny Meadows (William Terry) who is injured in the South Pacific. After being discharged and returning to the U.S., Meadows searches for the imaginary woman. He is informed of the truth by Dr. Leslie Ross (Virginia Grey), who is later murdered by Blake; in turn, Blake plans to murder Meadows. The film was notable for its noirish mise-en-scène and psychological depth that appeared in Mann's latter films. Mann then directed The Great Flamarion (1945), starring Erich von Stroheim and Mary Beth Hughes. During principal photography, Mann clashed with von Stroheim, describing him at length as "difficult. He was a personality, not really an actor ...He drove me mad. He was a genius. I'm not a genius: I'm a worker."

Mann moved to RKO to direct Two O'Clock Courage (1945), itself a remake of the 1936 film Two in the Dark, with Tom Conway and Ann Rutherford in the leading roles. That same year, he also directed Sing Your Way Home. Mann returned to Republic Pictures for Strange Impersonation (1946). He did The Bamboo Blonde (1946) at RKO.

Film noir and career breakthrough (1947–1949)
By 1946, Mann had signed with Eagle-Lion Films, a fledgling studio founded by Arthur B. Krim and Robert Benjamin. There, he directed Railroaded! (1947). According to Mann, the film was shot in ten days. A film review in Variety noted the film was "an old-type, blood-and-thunder gangster meller that's better than its no-name cast would indicate," and particular praised Mann for directing "with real acumen in developing maximum of suspense." That same year, T-Men (1947) was released. According to Elmer Lincoln Irey, the film originated from a rejected offer to dramatize the U.S. Treasury's investigation of Al Capone on tax evasion charges. Instead, Irey brought forward three cases related to the investigation. Initially budgeted at $400,000, T-Men was shot within three weeks from July 31 to August 23, with four days of reshoots in September. For the film, Mann specifically requested cinematographer John Alton, who was loaned out from Republic for the job, marking T-Men as their first collaboration. During its release, the film earned $2.5 million worldwide.

He went back to RKO for Desperate (1947), which he also co-wrote with Dorothy Atlas. A review in Variety positively wrote it was "a ripsnorting gangster meller, with enough gunplay, bumping off of characters and grim brutality to smack of pre-code days"; Mann's direction was noted as "being done skillfully". Mann returned to Eagle-Lion to direct Raw Deal (1948), reteaming with screenwriter John C. Higgins, screenwriter Leopold Atlas and actor Dennis O'Keefe. The film received positive notices from several publications, though it had been panned by Bosley Crowther from The New York Times.

Mann's success with Desperate and T-Men made Mann Eagle-Lion's most valuable director. In February 1948, Mann was hired to direct a dramatization of the storming of the Bastille, with Richard Basehart to portray an aide to General Lafayette. With Walter Wanger preoccupied with Joan of Arc (1948), he handed off supervisory duties to production designer William Cameron Menzies. Principal photography lasted 29 days, from August to September 1948, and cost $850,000. Reteaming with Alton, he and Mann developed a low-cost noir style, using low lighting levels and omnipresent shadows on minimal decor, high-angled camera shots, and rear projection for wide crowd shots. The resulting film was titled Reign of Terror (1949). After filming had begun, Mann was brought in to direct several scenes for He Walked by Night (1948), which also starred Basehart. Mann again collaborated with Higgins and Alton on the film. However, Alfred L. Werker was given the official director's credit.

While researching on T-Men (1947), Higgins and Mann had came across the topic of Border Patrol agents along the Mexico–United States border. Border Incident (1949) was initially developed at Eagle-Lion, but in December 1948, MGM's Dore Schary purchased the script for $50,000 and hired Mann to direct the film. Schary had also signed Mann onto a multi-picture contract with the studio. Beforehand, in July 1947, Mann and Francis Rosenwald had written a script for Follow Me Quietly (1949) that was first purchased by Jack Wrather Productions for Allied Artists. Don Castle was attached to star. Months later, in December, RKO announced it had purchased the script from Wrather and assigned Martin Rackin to write a new script.

Western films and collaborations with James Stewart (1950–1958)
The 1950s marked a notable turn in Mann's career, in which he directed a total of ten Western films throughout the decade (three of which were released in 1950). After Border Incident (1949), Mann was approached by Nicholas Nayfack, who asked him: "How would you like to direct a Western? I've a scenario here that seems interesting." He was handed the script for Devil's Doorway (1950), deeming it "the best script I had ever read." The film starred Robert Taylor, portraying a Shoshone native who faces prejudice after returning home in Medicine Bow, Wyoming following his decorated service in the American Civil War. Principal photography began on August 15, 1949 and lasted until mid-October. MGM initially withheld the film because of its topical subject, but released the film after Delmer Daves' Broken Arrow (1950), which starred James Stewart, had become successful. When released, the film was neither a critical or commercial success.

He followed this with a Western at Universal, starring James Stewart, Winchester '73 (1950). The film was originally set to be directed by Fritz Lang, but he felt Stewart was unsuitable for the lead role and dropped out. When Stewart had seen a rough cut of Devil's Doorway (1950), he suggested Mann as a replacement. Mann readily accepted, but threw out the script calling Borden Chase for a rewrite.  Principal photography began on February 14, 1950 in Tucson, Arizona for a thirty-day shooting schedule. The film was a commercial success, earning $2.25 million in distributor rentals becoming Universal Pictures' second-most successful film of 1950.

At the invitation of Hal Wallis, Mann directed the Western The Furies (1950) at Paramount starring Barbara Stanwyck and Walter Huston. Also released in summer 1950, the film grossed $1.55 million in distributor rentals in the United States and Canada. Mann reflected, "It had marvellous characters, interesting notices, but it failed because nobody in it cared about anything—they were all rudderless, rootless, and haters." In the fall of 1950, Mann was sent to Cinecittà to do second-unit work on Quo Vadis (1951). There, Mann worked 24 nights, filming the burning of Rome sequence with assistant cinematographer William V. Skall.

Side Street (1950) was the final film noir that Mann directed. The film starred Farley Granger and Cathy O'Donnell, reteaming after They Live by Night (1948). He next directed a period thriller with Dick Powell, The Tall Target (1952).

After the success of Winchester '73 (1950), Universal Pictures wanted another collaboration between Mann and Stewart. After a recommendation from one friend, Stewart proposed adapting the novel Bend of the River by Bill Gulick to Universal. The studio agreed and purchased the film rights. The actor and director made a contemporary adventure film, Thunder Bay (1953) at Universal. Feeling dissatisfied with the final film, Mann stated, "We tried but it was all too fabricated and the story was weak. We were never able to lick it ...It didn't get terribly good notices but of course it made a profit." Mann fulfilled his contract with MGM, when he and Stewart re-teamed for The Naked Spur (1953).

Mann and Stewart had their biggest success with The Glenn Miller Story (1954). During its release, the film earned $7 million in distributor rentals in the United States and Canada. That same year, he filmed The Far Country with Walter Brennan. The film would be Mann's last collaboration with Borden Chase.

Mann and Stewart paired for one more non-Western film, Strategic Air Command (1955). Stewart had served with the U.S. Air Force and pushed for a cinematic portrayal. With the cooperation of the Air Force, Mann agreed to direct the film, wanting to film the Convair B-36 and Boeing B-47 in action as the human characters, in his words, "were papier-mâché". During its release, the film earned $6.5 million at the box office. Mann's last collaboration with Stewart was The Man from Laramie (1955) at Columbia Pictures. The film was an adaptation from a serial by Thomas T. Flynn, first published in The Saturday Evening Post in 1954. The film was shot on location in Coronado, New Mexico, and in Sante Fe. The film was the favorite of Stewart's among their collaborative films. After the film's release, Harry Cohn asked Mann to direct another Western film for Columbia. Mann agreed and decided to direct The Last Frontier (1955). Mann offered Stewart the lead role to which he declined and instead cast Victor Mature.

In 1956, Stewart and Mann were to reunite on Night Passage (1957). Before filming was set to begin on September 4, Mann withdrew from the project. Contemporary accounts reported that Mann withdrew because he had not yet finished editing Men in War (1957). However, latter accounts state Mann had developed creative differences with Chase over the script, which Mann considered to be weak. Mann asked to be replaced, and James Neilson was brought in to direct. Stewart and Mann never collaborated on another project again.

Mann directed a musical starring Mario Lanza titled Serenade (1956). On set, he worked with actress Sara Montiel, who became his second wife. In August 1957, Mann announced he had acquired the film rights to Lion Feuchtwanger's novel This is the Hour, which told a fictionalized account of painter Francisco Goya. Montiel was set to portray Maria Teresa de Cayetana, Duchess of Alba. By February 1958, Mann had abandoned the project as a rival film titled The Naked Maja (1958) was in production. He then purchased the film rights to John McPartland's then-recently published novel Ripe Fruit, with Montiel set to star. However, the project failed to materialize.

Mann directed a Western starring Henry Fonda and Anthony Perkins titled The Tin Star (1957). Mann teamed with Philip Yordan to produce two movies starring Robert Ryan and Aldo Ray; the first being Men in War (1957) was about the Korean War. The film was the first of three Mann had directed for United Artists. His second project was a film adaptation of Erskine Caldwell's then-controversial novel God's Little Acre. Mann and producer Sidney Harmon had intended to film in Augusta, Georgia, but the novel's controversial subject matter heightened resistance from city leaders and local farmers. As a result, the production was denied permission to film in the state. In October 1957, they eventually selected Stockton, California. On both films, Yordan was given the official screenwriter credit, but Ben Maddow stated he had written both screenplays.

Mann later directed Gary Cooper in a Western, Man of the West (1958) for United Artists. Filming began on February 10, 1958, and ended later that same year. When it was released, Howard Thompson of The New York Times wrote the film was "good, lean, tough little Western" that was "[w]ell-acted and beautifully photographed in color and Cinema-Scope". Elsewhere, Jean-Luc Godard, then a critic for Cahiers du Cinéma, gave the film a raving review when it was released in France.

Widescreen films (1959–1964)
Mann was hired by Universal Pictures to direct Spartacus (1960), much to the disagreement of Kirk Douglas who felt Mann "seemed scared of the scope of the picture". Filming started on January 27, 1959 in Death Valley, California for the mine sequence. As filming continued, Douglas felt Mann had lost control of the film, writing in particular: "He let Peter Ustinov direct his own scenes by taking every suggestion Peter made. The suggestions were good—for Peter, but not necessarily for the film." With the studio's approval, Douglas was permitted to fire Mann. According to Douglas's account, Mann graciously exited the production on February 17, to which Douglas promised he "owe[d]" a film to him. A day later, Stanley Kubrick was hired to direct. Shortly after, Mann went to MGM to direct Glenn Ford in a remake of Cimarron (1960). During production, Mann had filmed on location for twelve days, but the shoot had experienced troublesome storms. In response, studio executives at MGM decided to relocate the production indoors. Mann disagreed, remarking the production had become "an economic disaster and a fiasco and the whole project was destroyed." Mann left the production, and was replaced by Charles Walters.

In July 1960, Mann was hired to direct El Cid (1961) for Samuel Bronston. The film starred Charlton Heston and Sophia Loren. In November 1960, before filming was to begin, Loren was displeased with her dialogue in the script, and requested for blacklisted screenwriter Ben Barzman to rewrite it. On an airplane trip to Rome, Mann retrieved Barzman and handed him the latest shooting script, to which Barzman agreed to rewrite from scratch. Filming began on November 14, 1960 and lasted until April 1961. Released in December 1961, El Cid was released to considerable acclaim from film critics, and earned $12 million in box office rentals from the United States and Canada.

Mann next directed The Fall of the Roman Empire (1964). The project's genesis began when Mann, who had recently finished filming El Cid  (1961), had spotted an Oxford concise edition of Edward Gibbon's six-volume series The History of the Decline and Fall of the Roman Empire near the front window at the Hatchards bookshop. Mann then read the book, and after a flight trip to Madrid, he pitched a film adaptation of the book to Bronston, to which the producer agreed. The film was intended to reunite Heston and Loren, but Heston departed the project to star in 55 Days at Peking (1963), another Bronston production. His role was subsequently assumed by Stephen Boyd. Filming began on January 14, 1963 and wrapped in July 1963. Released in March 1964, the film earned $1.9 million in box office rentals in the United States and Canada, against an estimated production budget of $16 million. That same year, in July, Mann served as the head of the jury at the 14th Berlin International Film Festival.

Later films (1965–1967)
In March 1963, Mann and producer S. Benjamin Fisz had reportedly begun development on The Unknown Battle, a historic re-telling of Norwegian resistance soldier Knut Haukelid's sabotage mission to prevent Nazi Germany from developing an atomic bomb during World War II. Barzman had been hired to write the script, with Allied Artists as a distributor. By February 1964, Boyd and Elke Sommer had been hired to portray the leading roles. However, in July, Kirk Douglas was hired to portray the lead role. In his memoir, Douglas accepted the role after receiving an unexpected phone call from Mann, fulfilling his earlier promise that he "owed" him a film. The film was then re-titled The Heroes of Telemark (1965).

In October 1966, Mann was announced to direct and produce the spy thriller A Dandy in Aspic (1968) for Columbia Pictures. By December, filming was set to begin in February 1967 where it would film on location in Austria, Germany, and London. At the time of his death, Mann was contemplating a Western film loosely adapted from King Lear, with sons replacing the daughters.

Personal life and death
In 1936, Mann married Mildred Kenyon, who worked as a clerk at a Macy's department store in New York City. The marriage produced two children, Toni (b. 1938) and Nina (b. 1944). The couple divorced in 1956. A year later, Mann married actress Sara Montiel, who had starred in Serenade (1956). In 1963, the marriage was annulled in Madrid. His third marriage was to Anna Kuzko, a ballerina formerly with Sadler's Wells, who had one son named Nicholas.

On April 29, 1967, Mann died from a heart attack in his hotel room in Berlin. At the time of his death, he had spent the last two weeks filming A Dandy in Aspic. The film was completed by the film's star Laurence Harvey. For his contribution to the motion picture industry, Anthony Mann has a star on the Hollywood Walk of Fame at 6229 Hollywood Boulevard.

Filmography

References
Notes

Citations

Bibliography

External links

  (as Anton Bundsmann)

 Anthony Mann Profile at Allmovie by Rovi
 Anthony Mann Profile at Turner Classic Movies

1906 births
1967 deaths
20th-century American male actors
Male actors from San Diego
American male film actors
American people of Austrian descent
American people of Czech descent
American people of German-Jewish descent
American male stage actors
Central High School (Newark, New Jersey) alumni
Film directors from California
People from Newark, New Jersey
Film directors from New Jersey
Western (genre) film directors
Writers from San Diego


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Only at that time teeth-whitening processes were just restricted to newsreaders and performers who needed to appear great when on the big screen or television. But teeth whitening gold coast appears to be a sort of exception.
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Besides laser treatment what options do we have?
It is not unlikely that she or he will urge one of professional treatments that are a couple of readily in at home or work. The fastest option is in office bleaching. She or he may use laser, a particular light, or heat in conjunction. You will see remarkable effects after the first session, although you may need a lot more than one session to reach the results you desire. An expert whitening alternative is even you can perform at home. The merchandise you use is determined by your budget and how fast you would like to find outcomes. Whichever alternative you select, be sure you consult a dental professional. Bleaching agents can cause irreversible damage to enamel and your gums.
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Saturdays are the best! Today, weather resembles that of the perfect spring day. I have already been out and about and gotten two loads of laundry done and gotten myself together! I find that getting up and getting ready, no matter what my plans consist of, helps me be more productive throughout the day. AND, if someone calls and asks to do something, I'm set to go!
This ensemble is light and casual. I typically wear it with flats, but I threw on a pair of heels to dress it up for the picture.


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Even as a second time mom, any kind of transition with your baby is overwhelming. The transition from bassinet to crib is just as nerve-wracking as the transition from hospital to home. Check out more about the HALO Bassinest we used and loved HERE. I loved having my new little babe in my bedroom with me for the first few months. Those first few months of time were crucial for bonding and mealtimes.
I have absolutely learned, as I was told previously, that every pregnancy and each child is different. With my first born we moved her over to her crib right on her 3rd month. She was sleeping through the night right away. She loved her crib and although I would stare at the monitor and cry while she snoozed away, she was perfect. With my second child, things have been quite different.
They say if it isn't broke then don't fix it, my first loved sleeping in a SleepSack. My second little babe is following in her sister's footsteps and wearing a SleepSack as well. It allows me to keep her warm at night, without the worry of an actual blanket. Making sure your baby is safe is always top of mind for parents; especially while sleeping.
Another bedtime soother we have been using is the Halo SnoozyPod. This miracle device helps soothe your baby to sleep with mesmerizing lights, vibrations and gentle tunes. It is designed to help with the transition from bassinet to crib. Or if you have an older child, this would help for the transition from crib to toddler/twin bed. Since she was used to these features in the bassinet, this allows her to have the same features in her crib.
The setup was quite simple and easy, it only took a few moments. My husband actually read the directions, let's give him a round of applause for that one! I don't play around when it comes to my babies and made him read it for proper installation. Technically, it was super easy and I could've done it myself but hey, he's home and willing to help- so I'll take it!
A great feature of the SnoozyPod is that it is Bluetooth enabled for iOS and Android, which allows me to use it from anywhere in the house. I have always used white noise for my kids because it helps keep outside noises to a minimum and helps in the afternoon with nap time as well. I can get housework done while they sleep as long as the white noise is running.
The SnoozyPod fits snuggly under the mattress leaving a safe, flat, firm surface for your child to comfortably sleep. It creates a calming vibration, soothing nature and womb white noise sounds plus starry-night projection light create the perfect environment to help your child fall and stay asleep. The starry-night projection uses a soft amber LED light because research shows amber light does not interrupt our body's circadian rhythm.
We still have not been able to get a full night's sleep, meaning through the night without waking just yet. I was told I was really lucky with my first being able to be sleep through the night right at 3 months. I don't believe in letting them "cry it out", so we will just be taking this transition a little slower than previously before but with the help of her SleepSack and SnoozyPod she will be comfortable and happy in the meantime.
Wanna get social with Halo?
None of my kids enjoyed a sleep sack! My best friend's daughter loved hers though! Glad it works for you guys.
First off she is absolutely precious. Second omg I think I need this. So my daughters a little under a year. Do you think this would be a good fit for her. I love the way it's controlled. That's so neat!!
The snoozy pad sounds awesome! My kids have always liked white noise in their room. And they LOVED their sleep sacks!
OOoOOH I've never heard of the soozypod but I'm going to look into this!
Precious girl! I've never heard of that! Would have loved to have had that when mine were little!
That Snoozy Pod sounds amazing!! My babies loved the swing because of the vibration, I'm sure this would have been a hit too!