"I highly recommend Varghese Orthodontics! From the friendly and efficient ladies at the front desk to the doctor himself, you will find professional and thorough care."
"Dr. Varghese and his team have always been very pleasant and straight forward with me and my son on what his orthodontic plan is. Very nice, clean facility as well."
"I have only had an evaluation at this point, however, I am DEFINITELY going to use Varghese Orthodontics for a little bit of straightening maintenance. The staff was exceptionally nice & extremely friendly! I am so thankful that there is such a great orthodontics business that is above and beyond, professional & courteous, and a bonus of being so close to my home!"
"I always have a good visit - it may hurt a little but it is working and that is what I need."
"Everyone that we have come in contact with in the Huntley office has been more than wonderful. Daughter is very happy with her progress and has little to no pain with all her treatments. That makes me happy! Wonderful staff - wonderful doctor! Who could ask for more?"
"Very helpful and took the time to explain everything in detail. Answered all of our questions."
"Great orthodontic practice! Dr. Varghese and staff are awesome to work with! The Huntley office is very fast and efficient."
"My daughter and I love this place. The Dr. and all the staff are some of the friendliest people I have ever met. They know exactly who you are and why you are there when you walk in the door. Anytime my daughter has had a problem with her braces (wires moving and pinching her cheek) they always fit her in asap. They really go out of their way at every appointment."
"Everytime we come in the entire staff is genuinely happy to see us. They are thoughtful and put my daughter at ease who is very apprehensive when it comes to her mouth. Dr. Varghese takes the time to explain everything that they are doing and how good the progress is. We wouldn't take our kids anywhere else!"
"I want to say how nice it is to not have a long wait once we arrive. Everyone is very kind and professional."
"The service is very good and the staff are very friendly. They made me feel welcome. They are very helpful and looked out for me."
"Very friendly, great to work with and great results."
"Always very friendly and great results."
"We came in for a consultation for Nathan Goglin. I had 3 other boys with me, and immediately they were entertaining in the lobby game room. Nathan was very nervous about the appointment, but was immediately relaxed when he met the cheery staff. The office staff gave us a tour of the building and then talked to Nathan about what it means to wear braces and how they will help him. Nathan left the appointment optimistic about having braces so much that he wanted to know how soon he could get them on. Thanks to everyone for making Nathan feel so comfortable."
"Staff was great. Went to get an impression for his retainer and because he lost so many baby teeth my son didn't have to get an impression. So he was able to get his braces off until we start phase two. That was his early holiday present. They really made him feel like it was a huge deal to get them off. He was so excited."
"The entire staff did a great job!!!Dr. Varghese is honest and caring, and I would highly recommend him!"
"The entire staff is so friendly. Office is very welcoming! We had two other consultations and Varghese Orthodontics was not only the best priced after insurance coverage, they really were so welcoming and took the time to talk and answer any questions. Highly recommend!"
"They were very nice and explained things very well. I like seeing the model teeth and the before and after pictures"
"we are always happy coming into Varghese Orthodontics. It is always fast, friendly & efficient!"
"We love coming to Dr Varghese. Everyone is so friendly and the appointments are always very quick."
"Dr. Varghese and his staff are always so personal and cheery. They really make my son feel comfortable. They talk with him and get him involved in the conversation and I think that really helps."
"A pleasant atmosphere and excellent work. I am happy to continue my treatment with Varghese Orthodontics."
"Dr. Varghese and his staff continually make my daughter feel at ease. As soon as you walk into the office you have happy, friendly people, always smiling, and asking how your day is, etc. Dr. Varghese is exceptional. From his professional expertise to his casual feel to making your child feel comfortable. He always communicates with you and makes you feel that your child is in good hands. I'm really happy with our decision in choosing Varghese Orthodontics!"
"Further recommended from my sister-in-law Tracy and having witnessed my niece's dental outcome, I am really glad we decided to seek orthodontic treatment early for my daughter. After my daughter's front tooth avulsed last year she became apprehensive when she had to get any dental or orthodontic treatment. Dr. Varghese reassured her with extra care and attention during her treatment and alternative solutions if her front tooth falls out. Varghese orthodontics is phenomenal and a professional place to handle any ordeal."
"I love the entire staff at Varghese Orthodontics. Everyone is very friendly. They are willing to take the time and explain all the steps of what they are doing. Very patient with kids. I would recommend Varghese Ortho 100%"
"Over the years, both my children received their perfect smiles from Varghese Orthodontics. Dr. Varghese and his staff have been a joy to work with. They have been very flexible with scheduling appointments and accomodating at the various locations. The clinic is very modern and both the kids loved going there. I have nothing but positive things to say about our experience with Varghese Orthodontics."
"Dr. Varghese is soooo incredible! He is actually the best doctor I have ever been to. I switched to Dr. Varghese from another orthodontist because I knew he was the best around. He went above and beyond when he called me at my state pole-vault competition to wish me luck! Thank you for your exceptional service."
"Angelina had a great experience during her appt. She had spacers put in. Staff explained in detail how everything worked. Angelina mentioned that the staff had a positive attitude. Great experience! Thank you!"
"Dr. Varghese and his team of professionals did an excellent job with my son's braces/procedure. We are very impressed with Dr. Varghese's modern, hi tech, and very spacious facility. Everything is done right in the premises. His staff are always very accommodating and friendly. We highly recommend Varghese Orthodontics for their knowledge and expertise in this field."
"My son came to Dr. Varghese's practice in Huntley at age 13. He had 4 baby teeth that just wouldn't come out on their own needed to be extracted and 3 teeth that had to be exposed and brackets put on so they can be moved into the right places. He underwent oral surgery, then a pretty extensive process of chains, brackets, etc to move those teeth. Dr. Varghese was excellent! He explained that my son was a tough case, yet always remained positive and in the end, my son's teeth are all in the proper place, alignment is perfect and he has a gorgeous smile. I figured the process would take years and truly only took approximately 20 months. I would recommend Dr. Varghese to anyone. Excellent professionalism and very personable."
"We love Dr Varghese! He is very professional and an all around great guy. He actually called my daughter at her state track meet to tell her good luck--you don't see doctors taking time out of their busy schedules to do those kind of things! We are very happy customers!"
"I am very happy with the orthodontic work done at this office."
"It was our first time visiting the office and we were impressed with the office and the staff. The office is clean and has games for kids. The staff was friendly and happy from the moment we walked in the door. Lindsey showed us around the office and introduced us to the staff. My son felt comfortable and happy. Dr Varghese is friendly and answered all of our questions. I would definitely recommend a visit to their office if you need braces."
"I absolutely love the entire staff here!! My daughter has such anxiety when it comes to her mouth being worked on and everyone makes her feel at ease each and every time she comes in. The progress her braces are making is amazing and she's had little to no pain."
"Everyone in the office is AWESOME."
"Varghese Orthodontics is awesome. Great care and I've never experienced any problems. Everyone is so helpful! Thanks"
"I have enjoyed the care that my daughter has received. The doctor and his staff are amazing. They truly aim to please their customers and I will truly miss seeing them once the braces come off. Thank you so much."
"What a fantastic place for orthodontics! The staff, orthodontist, and front desk are all exceptional people. My son loved the video area, and he always enjoyed going. Payment plans are very helpful, and state of the art equipment."
"Had brackets changed and adjusted. Painless and fast."
"Had an appointment last week for a consultation for my daughter to get braces put on. As we walked in the door, Lindsey greeted us and knew exactly who we were and what we were there for. She gave us a tour of the office and introduced us to everyone. We then went into a room and she explained the whole process to us, and then Dr. Varghese came in to examine my daughter. She felt very comfortable from the very start. Lindsey then showed a video, gave us our options and answered all of our questions. We felt very comfortable as soon as we walked in the door. As soon as we left my daughter said this is who I want to have put on my braces, she did not want to go anywhere else! She is excited to get her braces next week. I will recommend your office to anyone that is looking for an orthodontist."
"Dr. Varghese is fabulous orthodontist. He's honest, caring, upfront and very personable. He's great with the kids. I would recommend him to anyone thinking they might need orthodontic care--and I have! And the rest of his staff are so helpful & friendly. Orthodontics can be a chore, but this office makes it quite bearable, even pleasant."
"I originally had to have braces when my bottom 2 teeth were knocked in at a baseball game. Dr. Varghese helped save them by slowly moving them back in place. I then needed braces a few years later and knew who I wanted to go to! Dr. Varghese is the nicest, most patient and understanding orthodontist ever! He takes the time to explain everything. His office staff is fantastic also!"


I quit wearing a watch a few months back. I'd love to say that I was making some great statement about not allowing time to master me, but the truth is that I was tired of the watchband pulling my arm hair. I did observe that removing my watch did not change the constant ticking away of each second. Whether I was looking at the second hand move or not, one after another after another the seconds tick by never to be relived or recaptured.
You don't need to quit wearing a watch to learn that lesson. God has a lot to say to us about time.
Removing your watch won't slow down the ticking of time or alter it in any way. Time flies … whether you're having fun or not! Time marches on. Years pass. Perhaps you will make it past your 80th birthday, but your days on this world are limited. Barring the rapture, none of us will make it out alive! Knowing the fleeting nature of time and the fragility of life itself, how should we respond?
First, thank God for the time you have. Every day, every moment is a gift.
Second, use the time wisely. Work. Play. Worship. Serve. Eat. Sleep. There is a time for everything. We simply need to wisdom to use that time well.
Third, plan for eternity. You may or may not be a good planner, but the certainty of life's end should motivate each of us to plan for that day. Do you know you'll have a home with God in heaven? If not, is it something you're willing to leave to chance?


text:
Clemson wins 2nd National Championship in three years vs Alabama, 44-16
Clemson Coach Dabo Swinney Praises God After Winning National Championship
Shannon Reynolds | 10 January, 2019, 10:43
Because of the culture, our fans and for many other reasons, Death Valley will always hold special memories for me.With all this being said, it was a tough decision, but I left it in God's hands. The figures do not yet include ESPNEWS or streaming viewership.
Clemson made history last night by crushing Alabama, to win the national title. The two teams were meeting in the College Football Playoff for the fourth consecutive season. The ratings and viewership topped out at 16.2 and 27.8 million in the first half when the Tigers extended their lead to 15 points. "I'm just thankful to be a part of it".
Clemson's blowout victory over Alabama in the College Football Playoff drew a 14.6 overnight rating for ESPN across its multiple-channel broadcast, the lowest-rated title game in the 5-year-old postseason system.
Raptors sign former Golden State Warriors guard Patrick McCaw
ET - Watch on FuboTV with NBA League Pass add-on ), which is a great outcome to this whole scenario for him. After the guard signed a non guaranteed offer sheet with the Cavs, the Warriors decided not to match it.
Roger Federer in tears talking about his late coach Peter Carter
Federer has previously paid tribute to Carter in 2017 when he had won the Australian Open title after defeating Rafael Nadal . Federer expressed his love for the Australian tennis calendar, as there is much that connects him to the country.
Head Coach Dabo Swinney of the Clemson Tigers calls a play against the Georgia Tech Yellow Jackets on September 22, 2018 in Atlanta, Georgia.
Two seasons ago it was Deshaun Watson dethroning the Tide with a last-second touchdown pass. Clemson's new star quarterback didn't need the late-game heroics. "But I also told the players that sometimes we learn more when things don't go well, when we lose". "I think they're definitely ready for the next level". During the 1985-1986 season, Holieway took over as starting quarterback after Troy Aikman's leg was broken.
Man City and Burton are chalk and cheese, says Brewers chairman
We're not a team who has a lot of titles in our museum so you have to take these chances to get to the final. A last gasp penalty was enough to give the Welsh side a 2-1 win over the 2016 Premier League champions.
Celebrations as Duchess of Cambridge marks 37th birthday
Royal households, British embassies and charities of which Kate is patron are among those who posted their congratulations. He added: "I did remember this morning, so I was ok".
Wife of Norwegian millionaire kidnapped
The real estate investor owns 70% of the electricity company Elkraft, which he co-founded in 1992, Norwegian media reported. Investigators refused to confirm the amount but said they advised the family not to pay the purported kidnappers.
AMD Radeon VII revealed as AMD's 7nm flagship gaming GPU
Lisa Su hyped up the crowd a bit before announcing a preview of the third-generation Ryzen desktop processors. At CES 2019 , AMD today announced Radeon VII , the world's first 7nm gaming graphics card.
White House orders IRS to issue tax refunds despite shutdown
Millions of USA taxpayers will still receive refunds despite an ongoing partial government shutdown , the White House has said. A $3 billion "contingency" fund was appropriated by lawmakers for SNAP a year ago , The Post reports .
Leading shares indices across Asia and Europe rose as brief but positive statements appeared to encourage investors. On Monday, Chinese importers made another large purchase of United States soybeans, their third in the past month.
John Bercow blasted by Tory Brexiters as Theresa May suffers another defeat
It has been suggested that Brexit could be delayed if the deal is defeated in the "meaningful vote" to allow time to renegotiate elements of the deal.
Fantastic Four DLC content coming to Marvel's Spider-Man
At the very end, one of the presenters said, "Something fantastic is coming to Marvel's Spider-Man real soon". When you play Epic Quest: First Family, you automatically unlock Mister Fantastic right away.
Peak flu season starting now and may last longer, says doctor
Because the peak period came later this season, it is likely to extend to the middle or end of next month, he said. The ages of those who had died ranged from 40 to 91 years old and all had records of chronic disease.
Man accused of stealing $10 million lottery ticket from roommate
Part of the investigation included viewing the surveillance cameras at the store where the ticket was purchased. His punt on a pre-Christmas payout paid off big time with the ticket winning him $US10 million ($14 million).
Jimmy Kimmel plans on putting federal employees to work
And yet this time around, all the major networks said they'd provide coverage of the speech. FNC also beat ABC broadcast network (5.801M) in total viewers in the half hour.
Chelsea agree to sign Gonzalo Higuain as Alvaro Morata heads for Sevilla
Chelsea, for their part, are in need of a striker after deploying Eden Hazard as a false nine for a large chunk of the season. The Argentine thrived under Sarri's guidance at Napoli and broke the Serie A record with 37 goals in the 2015/2016 season.
United States pushes China on promises after `in-depth' trade meetings Meanwhile on the trade talks, sources said the two sides were still far apart from USA demands for structural reforms in China. Europe, Japan and other trading partners echo USA complaints those violate Beijing's market-opening obligations.
Kelly Manager For Threatening Victims Father The R&B singer is allegedly holding Joycelyn Savage against her will, according to her family, though she denies the allegations. A Cook County State's Attorney representative said officials are "in the process of reviewing and following up on these calls".
Flu season surging and likely not at peak in Canada, doctors say As of December 29, New Brunswick had 579 lab-confirmed cases, 577 of them influenza A and two of influenza B. Those in at-risk groups include people aged 65 and over, pregnant women and people with chronic illness.
In talks with Kim, China's Xi backs second North Korea-US summit However, neither side has provided details of what he has done since arriving aboard his personal armored train on Tuesday morning.
Jeff Bezos, Wife MacKenzie Bezos Divorcing After 25 Years The billionaire executive and his novelist wife have four children; one daughter, who they adopted from China, and three sons. Nobody really knows what "loving exploration" is or why these two broke up, and quite frankly, they probably don't care.
Macron's Popularity Edges Up Even as Protesters Persist Since the Yellow Vest demonstrations began, 5,600 were arrested and more than 1,000 were sentenced to prison, said Philippe. The proportion of people who declared themselves "very dissatisfied" by his leadership jumped by six points to 45 percent.
Timberwolves Coach Ryan Saunders Among Youngest in NBA History Karl-Anthony Towns and the Timberwolves will be playing for interim coach Ryan Saunders presumably for the rest of the season. The Minnesota Timberwolves could have interest in Hoiberg in either a head coaching or general manager capacity.
China Offering Bail Out For Malaysia's 1MDB Fund Can Backfire Since coming to power in May, Mahathir's government has accused the Najib administration of inflating the cost of Chinese deals. Malaysia's Finance Minister Lim Guan Eng told local media that he could not confirm the claims but would look into the matter.
Broncos hire Vic Fangio: Instant analysis of Denver's new head coach He's built dominant defenses in different eras, successfully adapting to changes in personnel, philosophies and style. A year ago when Matt Nagy was hired as head coach a big question was whether or not Vic Fangio would have stayed.
Trump threatens to stop federal aid for California wildfires Destructive wildfires erupted all over California in 2018, including the massive Camp Fire in Northern California. Newsom also pitched an additional $105 million to help California prevent and battle wildfires.
Thunder's Noel stretchered off floor following scary fall Noel rose up to meet him at the rim, and while the two were in mid-air, Wiggins' lead arm caught Noel right in the face. Westbrook made two more free throws to close the gap to the final margin of two points.
Gregg Williams relieved of duties, no longer with Browns Browns GM John Dorsey spoke highly of Kitchens' ability to improve the offense during his post-season press conference. ESPN's Chris Mortensen was the first to report the hiring, adding an official announcement will come later today.
Halifax demonstrators rally in support of B.C. First Nations pipeline blockade Coastal GasLink said it has signed agreements with 20 elected First Nations along the pipeline route, including the Wet'suwet'en. Protesters marched through downtown Toronto , chanting "TransCanada has got to go" and brought afternoon traffic to a halt.
Why Lindsay Lohan's staff wanted to work for her Mean Girls stars Lindsay Lohan and Jonathan Bennett got together over the weekend-and yes, his hair was pushed back. The cast of a MTV reality series that focuses on Lindsay Lohan's nightclub in Mykonos, Greece .
Rosenstein Ready to Leave Once Attorney General Confirmed, Source Says While a timetable for his departure is not set in stone, Barr could be confirmed as soon as the beginning of February. If confirmed, Barr would be in charge of Mueller, unless he too recused himself.
Konami Signs Exclusive Partnership With Juventus FC
Lampard reveals why Ethan Ampadu didn't travel on Chelsea's pre-season tour
Former Gonzaga standout Brandon Clarke named MVP of NBA Summer League
Neil Lennon hints at £50m Kieran Tierney valuation
British PM Hails England's World Cup Win

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: asp.net can't take the text of input text This is my aspx

Date: <input type="text" id="datepicker" >
        <asp:Button id="BookingForDate" runat="server" OnClick="BookingForDate_Click" Text="Search"/>

ID	PlanTime

on my code in c# I can't see datepicker
why?
note please that i can take all the controllers from id except this one.
I already tried restart the visual studio

A: You have 2 options
add runat="server" to the input
<input type="text" id="datepicker" runat="server" />

or create an TextBox
<asp:TextBox runat="server" id="datepicker"></asp:TextBox>

A: You should add
runat="server"

to your input. No you are using an html control and not an asp.net server side control. Hence you can't access the value of the textbox the way you want.
So try the following and then you will be able to access the value of your textbox:
<asp:TextBox id="datepicker" runat="server"/>

Then in your code behind class you can access the value of this textbox
datepicker.Text

Another approach, as I pointed initially, it would be the following:
<input type="text" id="datepicker" runat="server">

A: You have not given name to your control and also add runat="server"
<input type="text" id="datepicker" runat="server" name='datepicker' />

A: You forgot to add the runat-attribute to your input-tag. Try this:
<input type="text" id="datepicker" runat="server">

With that change, you should be able to access the element from code behind
See MSDN

redpajama_set_name: RedPajamaStackExchange


Dustin Hoffman could be appearing on Piers Morgan Tonight in the near future. Piers Morgan caught up with the legendary actor (and recent first-time director) on the red carpet for the Academy Awards, and the two talked about more than just Hollywood.
Hoffman revealed that he's a big fan of Morgan's, saying he doesn't often get "starstruck" but felt "extraordinary" to be standing next to the CNN host. At the tail end of a short conversation about the Oscars and Hoffman's new film Quartet, Hoffman told Morgan "God bless you for what you're saying about gun control," indicating that he's been watching Morgan's relentless advocacy since December's Newtown shooting.
Morgan invited Hoffman to come discuss the issue with him on his CNN show, adding that up until now Hoffman has been "elusive." We'll see if Hoffman remains an unattainable guest or if he pops up on CNN soon to share more of his views about guns.


text:
Mercedes starts production of the AMG GT R and GT Roadster
India, March 5 -- Production of the new AMG GT R and GT Roadsters is in full swing at Mercedes-Benz's Sindelfingen plant in Germany. Sources report that the brand will put together close to 2,000 units of the GT R. Mercedes starts production of the AMG GT R and GT Roadster Each of these cars are crafted entirely by hand by a few expert engineers. And since it is a complex design, it takes ten of these specialised employees to work in close association with each other to mate the drivetrain to the body. Mercedes-AMG will equip the new GT R with the brand's 4.0-litre biturbo motor which is capable of making 585bhp and 700Nm of torque. An entry-level GT Roadster with a power output of 476bhp will also be offered, and can hit 0-100kmph in just 4sec. Michael Bauer, plant manager at Sindelfingen, said, 'The cooperation with Affalterbach works very well. We, at Sindelfingen are proving once again that we can not only handle large-scale, but also small-scale production - a top performance from the team.' Reports state that the new AMG GT R and GT Roadster may be introduced in June this year. Mercedes starts production of the AMG GT R and GT Roadster
Next Article Mercedes-Benz E-Class LWB to be launched in India tomorrowMonday, February 27, 2017
Aston Martin Vantage AMR unveiled Tuesday, June 20, 2017
Hyundai to launch two more SUVs Tuesday, June 20, 2017


text:
The contribution of the S-phase checkpoint genes MEC1 and SGS1 to genome stability maintenance in Candida albicans
Melanie Legrand, Christine L. Chan, Peter A. Jauert, David T. Kirkpatrick
Biology Teaching and Learning
Genome rearrangements, a common feature of Candida albicans isolates, are often associated with the acquisition of antifungal drug resistance. In Saccharomyces cerevisiae, perturbations in the S-phase checkpoints result in the same sort of Gross Chromosomal Rearrangements (GCRs) observed in C. albicans. Several proteins are involved in the S. cerevisiae cell cycle checkpoints, including Mec1p, a protein kinase of the PIKK (phosphatidyl inositol 3-kinase-like kinase) family and the central player in the DNA damage checkpoint. Sgs1p, the ortholog of BLM, the Bloom's syndrome gene, is a RecQ-related DNA helicase; cells from BLM patients are characterized by an increase in genome instability. Yeast strains bearing deletions in MEC1 or SGS1 are viable (in contrast to the inviability seen with loss of MEC1 in S. cerevisiae) but the different deletion mutants have significantly different phenotypes. The mec1Δ/Δ colonies have a wild-type colony morphology, while the sgs1Δ/Δ mutants are slow-growing, producing wrinkled colonies with pseudohyphal-like cells. The mec1Δ/Δ mutants are only sensitive to ethylmethane sulfonate (EMS), methylmethane sulfonate (MMS), and hydroxyurea (HU) but the sgs1Δ/Δ mutants exhibit a high sensitivity to all DNA-damaging agents tested. In an assay for chromosome 1 integrity, the mec1Δ/Δ mutants exhibit an increase in genome instability; no change was observed in the sgs1Δ/Δ mutants. Finally, loss of MEC1 does not affect sensitivity to the antifungal drug fluconazole, while loss of SGS1 leads to an increased susceptibility to fluconazole. Neither deletion elevated the level of antifungal drug resistance acquisition.
Fungal Genetics and Biology
https://doi.org/10.1016/j.fgb.2011.04.005
Antifungal drug resistance
Cell cycle checkpoint
Genome stability
SGS1
10.1016/j.fgb.2011.04.005
Fingerprint Dive into the research topics of 'The contribution of the S-phase checkpoint genes MEC1 and SGS1 to genome stability maintenance in Candida albicans'. Together they form a unique fingerprint.
S Phase Cell Cycle Checkpoints Medicine & Life Sciences
Genomic Instability Medicine & Life Sciences
Fungal Drug Resistance Medicine & Life Sciences
Candida albicans Medicine & Life Sciences
Saccharomyces cerevisiae Medicine & Life Sciences
Fluconazole Medicine & Life Sciences
Maintenance Medicine & Life Sciences
Legrand, M., Chan, C. L., Jauert, P. A., & Kirkpatrick, D. T. (2011). The contribution of the S-phase checkpoint genes MEC1 and SGS1 to genome stability maintenance in Candida albicans. Fungal Genetics and Biology, 48(8), 823-830. https://doi.org/10.1016/j.fgb.2011.04.005
The contribution of the S-phase checkpoint genes MEC1 and SGS1 to genome stability maintenance in Candida albicans. / Legrand, Melanie; Chan, Christine L.; Jauert, Peter A.; Kirkpatrick, David T.
In: Fungal Genetics and Biology, Vol. 48, No. 8, 01.08.2011, p. 823-830.
Legrand, M, Chan, CL, Jauert, PA & Kirkpatrick, DT 2011, 'The contribution of the S-phase checkpoint genes MEC1 and SGS1 to genome stability maintenance in Candida albicans', Fungal Genetics and Biology, vol. 48, no. 8, pp. 823-830. https://doi.org/10.1016/j.fgb.2011.04.005
Legrand M, Chan CL, Jauert PA, Kirkpatrick DT. The contribution of the S-phase checkpoint genes MEC1 and SGS1 to genome stability maintenance in Candida albicans. Fungal Genetics and Biology. 2011 Aug 1;48(8):823-830. https://doi.org/10.1016/j.fgb.2011.04.005
Legrand, Melanie ; Chan, Christine L. ; Jauert, Peter A. ; Kirkpatrick, David T. / The contribution of the S-phase checkpoint genes MEC1 and SGS1 to genome stability maintenance in Candida albicans. In: Fungal Genetics and Biology. 2011 ; Vol. 48, No. 8. pp. 823-830.
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title = "The contribution of the S-phase checkpoint genes MEC1 and SGS1 to genome stability maintenance in Candida albicans",
abstract = "Genome rearrangements, a common feature of Candida albicans isolates, are often associated with the acquisition of antifungal drug resistance. In Saccharomyces cerevisiae, perturbations in the S-phase checkpoints result in the same sort of Gross Chromosomal Rearrangements (GCRs) observed in C. albicans. Several proteins are involved in the S. cerevisiae cell cycle checkpoints, including Mec1p, a protein kinase of the PIKK (phosphatidyl inositol 3-kinase-like kinase) family and the central player in the DNA damage checkpoint. Sgs1p, the ortholog of BLM, the Bloom's syndrome gene, is a RecQ-related DNA helicase; cells from BLM patients are characterized by an increase in genome instability. Yeast strains bearing deletions in MEC1 or SGS1 are viable (in contrast to the inviability seen with loss of MEC1 in S. cerevisiae) but the different deletion mutants have significantly different phenotypes. The mec1Δ/Δ colonies have a wild-type colony morphology, while the sgs1Δ/Δ mutants are slow-growing, producing wrinkled colonies with pseudohyphal-like cells. The mec1Δ/Δ mutants are only sensitive to ethylmethane sulfonate (EMS), methylmethane sulfonate (MMS), and hydroxyurea (HU) but the sgs1Δ/Δ mutants exhibit a high sensitivity to all DNA-damaging agents tested. In an assay for chromosome 1 integrity, the mec1Δ/Δ mutants exhibit an increase in genome instability; no change was observed in the sgs1Δ/Δ mutants. Finally, loss of MEC1 does not affect sensitivity to the antifungal drug fluconazole, while loss of SGS1 leads to an increased susceptibility to fluconazole. Neither deletion elevated the level of antifungal drug resistance acquisition.",
keywords = "Antifungal drug resistance, Cell cycle checkpoint, Genome stability, MEC1, SGS1",
author = "Melanie Legrand and Chan, {Christine L.} and Jauert, {Peter A.} and Kirkpatrick, {David T.}",
doi = "10.1016/j.fgb.2011.04.005",
journal = "Fungal Genetics and Biology",
T1 - The contribution of the S-phase checkpoint genes MEC1 and SGS1 to genome stability maintenance in Candida albicans
AU - Legrand, Melanie
AU - Chan, Christine L.
AU - Jauert, Peter A.
AU - Kirkpatrick, David T.
N2 - Genome rearrangements, a common feature of Candida albicans isolates, are often associated with the acquisition of antifungal drug resistance. In Saccharomyces cerevisiae, perturbations in the S-phase checkpoints result in the same sort of Gross Chromosomal Rearrangements (GCRs) observed in C. albicans. Several proteins are involved in the S. cerevisiae cell cycle checkpoints, including Mec1p, a protein kinase of the PIKK (phosphatidyl inositol 3-kinase-like kinase) family and the central player in the DNA damage checkpoint. Sgs1p, the ortholog of BLM, the Bloom's syndrome gene, is a RecQ-related DNA helicase; cells from BLM patients are characterized by an increase in genome instability. Yeast strains bearing deletions in MEC1 or SGS1 are viable (in contrast to the inviability seen with loss of MEC1 in S. cerevisiae) but the different deletion mutants have significantly different phenotypes. The mec1Δ/Δ colonies have a wild-type colony morphology, while the sgs1Δ/Δ mutants are slow-growing, producing wrinkled colonies with pseudohyphal-like cells. The mec1Δ/Δ mutants are only sensitive to ethylmethane sulfonate (EMS), methylmethane sulfonate (MMS), and hydroxyurea (HU) but the sgs1Δ/Δ mutants exhibit a high sensitivity to all DNA-damaging agents tested. In an assay for chromosome 1 integrity, the mec1Δ/Δ mutants exhibit an increase in genome instability; no change was observed in the sgs1Δ/Δ mutants. Finally, loss of MEC1 does not affect sensitivity to the antifungal drug fluconazole, while loss of SGS1 leads to an increased susceptibility to fluconazole. Neither deletion elevated the level of antifungal drug resistance acquisition.
AB - Genome rearrangements, a common feature of Candida albicans isolates, are often associated with the acquisition of antifungal drug resistance. In Saccharomyces cerevisiae, perturbations in the S-phase checkpoints result in the same sort of Gross Chromosomal Rearrangements (GCRs) observed in C. albicans. Several proteins are involved in the S. cerevisiae cell cycle checkpoints, including Mec1p, a protein kinase of the PIKK (phosphatidyl inositol 3-kinase-like kinase) family and the central player in the DNA damage checkpoint. Sgs1p, the ortholog of BLM, the Bloom's syndrome gene, is a RecQ-related DNA helicase; cells from BLM patients are characterized by an increase in genome instability. Yeast strains bearing deletions in MEC1 or SGS1 are viable (in contrast to the inviability seen with loss of MEC1 in S. cerevisiae) but the different deletion mutants have significantly different phenotypes. The mec1Δ/Δ colonies have a wild-type colony morphology, while the sgs1Δ/Δ mutants are slow-growing, producing wrinkled colonies with pseudohyphal-like cells. The mec1Δ/Δ mutants are only sensitive to ethylmethane sulfonate (EMS), methylmethane sulfonate (MMS), and hydroxyurea (HU) but the sgs1Δ/Δ mutants exhibit a high sensitivity to all DNA-damaging agents tested. In an assay for chromosome 1 integrity, the mec1Δ/Δ mutants exhibit an increase in genome instability; no change was observed in the sgs1Δ/Δ mutants. Finally, loss of MEC1 does not affect sensitivity to the antifungal drug fluconazole, while loss of SGS1 leads to an increased susceptibility to fluconazole. Neither deletion elevated the level of antifungal drug resistance acquisition.
KW - Antifungal drug resistance
KW - Cell cycle checkpoint
KW - Genome stability
KW - MEC1
KW - SGS1
U2 - 10.1016/j.fgb.2011.04.005
DO - 10.1016/j.fgb.2011.04.005
JO - Fungal Genetics and Biology
JF - Fungal Genetics and Biology


text:
package org.semanticscience.narf.structures.lib;

import java.io.BufferedReader;
import java.io.IOException;
import java.io.InputStream;
import java.io.InputStreamReader;
import java.io.OutputStream;
import java.io.PrintWriter;

public class StreamGobbler extends Thread{
    InputStream is;
    String type;
    OutputStream os;

    public StreamGobbler(InputStream is, String type)
    {
        this(is, type, null);
    }

    public StreamGobbler(InputStream is, String type, OutputStream redirect)
    {
        this.is = is;
        this.type = type;
        this.os = redirect;
    }

    public void run()
    {
        try
        {

        	PrintWriter pw = null;
            if (os != null)
                pw = new PrintWriter(os);

            InputStreamReader isr = new InputStreamReader(is);
            BufferedReader br = new BufferedReader(isr);
            String line=null;

            while ( (line = br.readLine()) != null)
            {
                if (pw != null){
                    pw.println(line);
                }

            }
            if (pw != null)
                pw.flush();
        } catch (IOException ioe){
            ioe.printStackTrace();
        }
    }
}

redpajama_set_name: RedPajamaGithub


text:
Home Infoservice Newsletter Newsletter 2018 May 2018
Newsletter: May 2018
What is the current state of health research in Germany? What are the challenges? And why are international partnerships so important in this area? In this edition we report on the latest developments and collaborations. You can also read how a young man from Yemen became one of Germany's best-known science communicators, learn about current funding programmes and discover our number of the month.
IN FOCUS: Health research
Researching for the sake of health
Medical research in Germany is making considerable progress, such as in the field of cancer therapy. This requires imaginative scientists who pursue their goals single-mindedly.
Better blood plasma for a wider range of applications
A start-up from Mannheim wants to ensure even better use of donor blood. To this end, it is also seeking exchange with researchers from Australia.
CAREER & FUNDING
Science communication as a career option
His father wanted him to become a farmer. Instead, Hashem Al-Ghaili is now one of the most successful science communicators in Germany and beyond. His videos are watched by millions of people.
Research Alumni Conference "Research towards Trustworthiness and Self-Determination in a Networked Society"
The Weizenbaum Institute for the Networked Society in cooperation with various partner institutions is inviting former guest researchers to a multidisciplinary conference in Boston, MA, USA from 24 to 25 September 2018. Researchers who spent a research stay at one of the consortium partners and who currently reside in the USA or Canada are eligible to apply until 13 May 2018.
www.alumni.tu-berlin.de > Research Alumni Conference
Funding for Junior Research Groups from the German Centre for Cardiovascular Research
The German Centre for Cardiovascular Research (DZHK) provides funding for Junior Research Groups. The current round of applications runs from now until 30 June 2018.
Scholarships from the Konrad-Adenauer-Stiftung
Through its scholarship programme, the Konrad-Adenauer-Stiftung supports international students and doctoral students at German universities. Applications in Germany are invited from 1 June until 15 July 2018.
Jeff Schell Scholarship from the Bayer Foundations
Through their Jeff Schell Scholarship, the Bayer Foundations support students and doctoral students in the agricultural and environmental sciences. The next round of applications will run from 1 June until 18 July 2018.
That's how many children and teenagers between the ages of five and 19 are obese. Young researchers are studying the influence of our genetic make-up and looking into personalised diets.
"Research in Germany" information seminar at Waseda University, Tokyo, Japan
Interested in doing a PhD or postdoc in Germany? Looking for an appropriate programme and funding opportunities? Meet the "Research in Germany" team at Waseda University in Tokyo on 17 May 2018 between 1 pm and 6 pm. Registration is possible until 15 May.
"Research in Germany" at the 11th Annual NIH Career Symposium, Washington, D.C., USA
Come and join us at the 11th Annual Career Symposium of the National Institutes of Health in Washington, D.C. on 18 May! This event is the best opportunity for students, graduates and professionals to learn about the many choices of an academic career in Germany.
"Research in Germany" at the BCF Career Event, Utrecht, Netherlands
Ready to take the next step in your scientific career? Meet our delegation of German universities and research institutions at the BCF Career Event in Utrecht on 24 May. Take the opportunity and learn about vacant PhD and postdoctoral positions in Germany!
"Research in Germany" information seminar, Seoul, South Korea
Interested in doing a PhD or postdoc in Germany? Join the "Research in Germany" team at the Goethe Institute Korea in Seoul on 24 May 2018 to find out more about PhD programmes, funding opportunities and much more. Please register until 22 May.
"Research in Germany" online talks, 4 to 7 June 2018
Join our online talks from 4 to 7 June with experts from German research institutions and testimonials from all over the world giving you an insight in the German research landscape, funding opportunities and many more! The online talks are free of charge and will be conducted in English.
Last Update: 09 Jul 2020
Newsletter 2020 Newsletter 2019 Newsletter 2018
January 2018 February 2018 March 2018 April 2018 May 2018
Researching for the sake of health Better blood plasma for a wider range of applications Science communication as a career option Funding for Junior Research Groups from the German Centre for Cardiovascular Research Scholarships from the Konrad-Adenauer-Stiftung Jeff Schell Scholarship from the Bayer Foundations Number of the Month: 124 million
June 2018 Newsletter: July 2018 Newsletter: August 2018 Newsletter: September 2018 Newsletter: October 2018 November 2018 Newsletter: December 2018
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text:
British Neo-Nazi Who Called for 'Extermination' of Jews Sentenced to 7 Years in Jail
by Algemeiner Staff
Convicted British neo-Nazi Andrew Dymock is seen wearing a mask in a propaganda video. Photo: UK Counter Terrorism Policing North East.
A UK court has sentenced a neo-Nazi who called for all Jews to be "exterminated" to seven years in jail.
Andrew Dymock, 24, from Bath, led the outlawed groups System Resistance Network (SRN) and Sonnenkrieg Division. He was convicted of 15 offenses and jailed for seven years, with a further three years on extended license, the BBC reported.
Judge Mark Dennis said he believed Dymock was dangerous and posed a "significant risk of serious harm" to the public.
"It is clear you were a leader and not a follower," he said.
He added Dymock was an "intelligent, well-read" person but also "wholly misguided." He stressed that Dymock was "driven by an extremist mindset" and had taken the path of "total hatred and bigotry."
Dymock's trial last month revealed that he had used the SRN website and a Twitter account to state that Jewish people should be exterminated and to encourage lone actor terror attacks. He advocated for a "race war," and called for gay people to be "purged" from society.
The former student had been supported throughout his trial by his parents, with whom he lived.
The court heard they had written to the judge asking for leniency ahead of the sentencing. Defense lawyer Andrew Morris said they were "extremely worried" about the impact of a prison sentence on their son.
After hearing the judge's sentence in court, Dymock responded, "thank you for killing me."
Dymock, who at the time was studying politics at Aberystwyth University in Wales, denied being behind the SRN accounts, claiming he was framed by an ex-girlfriend, who had failed to recruit him to join banned terrorist group National Action (NA).
He denied being a neo-Nazi and told police: "In fact, I am bisexual but lean towards being homosexual, in direct conflict with Nazism."
He was found guilty of five charges of encouraging terrorism, two of fundraising for terrorism, four counts of disseminating terrorist publications, possessing a terrorist document, stirring up racial hatred and hatred based on sexual orientation, and possessing racially inflammatory material.


text:
The art of drinking Vodka
Vodka first produced in some countries located at Eastern European, especially in Russian, Poland and Litva. It also had a long time tradition at Northern European where often called by the name of Vodka.
Vodka is a pleasant part of anyone's life if the drinkers can control how much do they drink. Vodka is a favorite beverage of many males, to be a friend of them, even too be friendly, freely no requirement and no judgement. It is simple to be familiar with Vodka. It is not necessary to have an outside or inside view of it. It is simple to have a drink of it and enjoy its story and delicious taste.
Vodka's purity is described as water
Rooting for the word "Voda" (meaning of "water"). The name of vodka can be understand to be "a little of water". Corresponding to the name of it, vodka is described as "no smell, no color and no taste of alcohol. The first two characters are not agreed at sight, however, no all kind of vodka has a light taste of alcohol which is enough to make drinkers feel comfortable to say that they do not feel any taste of alcohol.
Vodka was stated to be rooted in the Northern Europe region. Polander affirmed that they distilled vodka since the 8th century, before the early birth of vodka originally named 'gorzalka' in the 11th century. Russian also said that vodka is a beloved child. Khylnovsk supposed to be a factory of distillering precursor vodka since 1174, 800km far away the capital of Moscow at the eastern region. Vodka was rooted from a variety of sources, therefore, Vodka might have the ability of being familiar with all cultures and become the most popular kind of alcohol beverage in the world.
Ingredients of producing vodka is simple and available: oat, corn, sugar beets, potatoes, fruits even from sugar. Russian mainly used the following ingredient such as rice while Polander used a variety of material.
One of the most favorite taste of enjoying Vodka with ginger beer and lemon.
It is summarized briefly the process of vodka distillation as follows: raw sugar is extracted and converted into alcohol, then a few times of distillation. Six times seems to be the perfect method of producing the best quality of neutral vodka which is the traditional one of production and afterwards, adding the final step of filtering distilled product through activated carbon, to lose the unique character of odor, taste or color. Most of vodka is diluted by adding water before bottling process. The amount of water can account up to 58% of bottle volume.
In fact, it is said that vodka can be made from anything and in any way in your imagination. Vodka and other types of distilled spirits are home-made product in over the world following the different formulas and processes. For example, liquor made from fermented rice in Vietnam is the most familiar example.
Vodka is an indispensable part of Russian culture. This beverage is distilled long-time ago before appearance of vodka in the world. Everywhere in this cold region, they take one sip, sometimes gulp it. The Russian also often lessen it by using with Coca-Cola, Sprite, canned fruit juice and beer is the most popular. An old Russian has a claim of "Vodka without beer is like to throw money out the window."
Choose reasonable size of glass and a half of content
How to drink fruit juices mixed vodka in the bar / club in Vietnam? However, there are many ways for women to drink. Drink needs a certain understanding and a sense of abiding by certain principles.
First, it should not drink alcohol when your stomach is empty. It is necessary to have a snack in one to two hours in advance. Besides, the foods together with butter will effect into reducing the process of drawing alcohol into body
Second, how to choose vodka. Do not drink vodka mixing shot, do not select the type of flavored vodka. In fact, it still exist some kind of vodka to be mixed like pepper, anise, chocolate … If you want to have this taste, please add it by yourself rather than using bottled products available from the factory. Then, choosing what kind of vodka depends on the taste. Some people like the Poland, some like the Swiss, while the other like France … But in general, Russian vodka has been evaluated the most favorite.
If possible, the seafood is a best choice of using with vodka
Third, it should drink vodka in a traditional way, i.e drink directly. Chilled bottle of vodka should be chilled in about two hours to make the liquid in the bottle become viscous before drinking. The Russians can drink in a quite large glass and quaff. We should choose the type of glass of medium size, fill a half of glass, it is as well a tip of avoid drinking a lot. To drink up and not sipping.
Last but not least, in order to fully enjoy the spirit of vodka, it is often served with dishes cooked from his hometown of vodka. That will bring its own sense of drinking vodka and thereby realize clearly that all kinds of vodka are the same. Normally, the chilled vodka goes with rough processing seafood, caviar, smoked fish, lobsters.
Black Russian-White Russian
Cosmopolition
Vodka is a main component of making cocktail. Its advantage is no color, no smell and no taste. Vodka is easy to combine with other liquor and other ingredients. Vodka is a best choice of mixing cocktail because it does not make lost of taste's other ingredients. On the contrary, the higher the percentage of vodka it is, the higher smelling of other ingredients it is. In the world, some well-known brand of vodka is namely such as Black Russian – White Russian, Black-White Russian, Martini, Cosmopolition, Bloody Mary, Sex on the beach and other various formula.
Vodka, similar to other kind of liquor, is for enjoying your life. Therefore, it is necessary to have a drink with partner in the allowed limitation.
Source: vanhoaamthuc
Stop doing things after drinking alcoholic beverage
Vodka Hà Nội: Viet brand affirming
Halico News
Anniversary of Vietnamese Woman Day 20th Oct at Hanoi Liquor ., JSC (HALICO)
Liver detoxification by normal ingredients


After a successful Red and White meet (and a close White team victory) a few swimmers stood out as swimmers of the meet: Franco, Lukas, Kayla, Lily, Ashton, and Gabi.
This was Franco's first swim meet ever, and he was able to compete at a high level, bringing in a win as the anchor to the medley relay, where he swam a :31.57 50 freestyle.
This was Lukas's first meet in several years, but his leadership abilities were evident as he helped out many of the new swimmers get lined up and find their relays.
Kayla, Lily, Ashton, and Gabi all have had an awesome first meet of their lives! All of them asked good questions, and were ready for their events when it was time to swim.
Kayla won her 50 free with a time of :40.12. Lily swam very hard in all of her events and showed a lot of sportsmanship when she was cheering for her teammates. Ashton placed very well and competed against the 8 year olds, even though he is only 6! Gabi helped her teammates line up and find their lanes, even though this was her first meet ever. That's the kind of teammate we love!


text:
Two-step synthesis of multi-substituted amines by using an N-methoxy group as a reactivity control element
Makoto Yoritate, Tatsuhiko Meguro, Naoya Matsuo, Kenji Shirokane, Takaaki Sato, Noritaka Chida
The development of a two-step synthesis of multi-substituted N-methoxyamines from N-methoxyamides is reported. Utilization of the N-methoxy group as a reactivity control element was the key to success in this two-step synthesis. The first reaction involves a N-methoxyamide/aldehyde coupling reaction. Whereas ordinary amides cannot condense with aldehydes intermolecularly due to the poor nucleophilicity of the amide nitrogen, the N-methoxy group enhances the nucleophilicity of the nitrogen, enabling the direct coupling reaction. The second reaction in the two-step process was nucleophilic addition to the N-methoxyamides. Incorporation of the N-methoxy group into the amides increased the electrophilicity of the amide carbonyls and promoted the chelation effect. This nucleophilic addition enabled quick diversification of the products derived from the first step. The developed strategy was applicable to a variety of substrates, resulting in the elaboration of multi-substituted piperidines and acyclic amines, as well as a substructure of a complex natural alkaloid. Remote control: A two-step synthesis of multi-substituted N-methoxyamines including amide/aldehyde coupling and nucleophilic addition to amide carbonyls is reported (see scheme; TMS=trimethylsilyl). Incorporation of the N-methoxy group to the amides dramatically changes their reactivities, and enables quick access to diverse multi-substituted piperidines and acyclic substituted amines.
「Two-step synthesis of multi-substituted amines by using an N-methoxy group as a reactivity control element」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。
Amides Engineering & Materials Science 100%
Amines Engineering & Materials Science 78%
Amine Chemical Compounds 42%
Aldehydes Engineering & Materials Science 41%
Nucleophilic Addition Chemical Compounds 30%
Piperidines Chemical Compounds 24%
Nucleophilicity Chemical Compounds 22%
Yoritate, M., Meguro, T., Matsuo, N., Shirokane, K., Sato, T., & Chida, N. (2014). Two-step synthesis of multi-substituted amines by using an N-methoxy group as a reactivity control element. Chemistry - A European Journal, 20(26), 8210-8216. https://doi.org/10.1002/chem.201402231
Two-step synthesis of multi-substituted amines by using an N-methoxy group as a reactivity control element. / Yoritate, Makoto; Meguro, Tatsuhiko; Matsuo, Naoya; Shirokane, Kenji; Sato, Takaaki; Chida, Noritaka.
In: Chemistry - A European Journal, Vol. 20, No. 26, 23.06.2014, p. 8210-8216.
Yoritate, M, Meguro, T, Matsuo, N, Shirokane, K, Sato, T & Chida, N 2014, 'Two-step synthesis of multi-substituted amines by using an N-methoxy group as a reactivity control element', Chemistry - A European Journal, vol. 20, no. 26, pp. 8210-8216. https://doi.org/10.1002/chem.201402231
Yoritate M, Meguro T, Matsuo N, Shirokane K, Sato T, Chida N. Two-step synthesis of multi-substituted amines by using an N-methoxy group as a reactivity control element. Chemistry - A European Journal. 2014 6 23;20(26):8210-8216. https://doi.org/10.1002/chem.201402231
Yoritate, Makoto ; Meguro, Tatsuhiko ; Matsuo, Naoya ; Shirokane, Kenji ; Sato, Takaaki ; Chida, Noritaka. / Two-step synthesis of multi-substituted amines by using an N-methoxy group as a reactivity control element. In: Chemistry - A European Journal. 2014 ; Vol. 20, No. 26. pp. 8210-8216.
@article{d8d56eb4627f466d82d92be4ddce784d,
title = "Two-step synthesis of multi-substituted amines by using an N-methoxy group as a reactivity control element",
abstract = "The development of a two-step synthesis of multi-substituted N-methoxyamines from N-methoxyamides is reported. Utilization of the N-methoxy group as a reactivity control element was the key to success in this two-step synthesis. The first reaction involves a N-methoxyamide/aldehyde coupling reaction. Whereas ordinary amides cannot condense with aldehydes intermolecularly due to the poor nucleophilicity of the amide nitrogen, the N-methoxy group enhances the nucleophilicity of the nitrogen, enabling the direct coupling reaction. The second reaction in the two-step process was nucleophilic addition to the N-methoxyamides. Incorporation of the N-methoxy group into the amides increased the electrophilicity of the amide carbonyls and promoted the chelation effect. This nucleophilic addition enabled quick diversification of the products derived from the first step. The developed strategy was applicable to a variety of substrates, resulting in the elaboration of multi-substituted piperidines and acyclic amines, as well as a substructure of a complex natural alkaloid. Remote control: A two-step synthesis of multi-substituted N-methoxyamines including amide/aldehyde coupling and nucleophilic addition to amide carbonyls is reported (see scheme; TMS=trimethylsilyl). Incorporation of the N-methoxy group to the amides dramatically changes their reactivities, and enables quick access to diverse multi-substituted piperidines and acyclic substituted amines.",
author = "Makoto Yoritate and Tatsuhiko Meguro and Naoya Matsuo and Kenji Shirokane and Takaaki Sato and Noritaka Chida",
publisher = "Wiley-VCH Verlag",
T1 - Two-step synthesis of multi-substituted amines by using an N-methoxy group as a reactivity control element
AU - Yoritate, Makoto
AU - Meguro, Tatsuhiko
AU - Matsuo, Naoya
AU - Shirokane, Kenji
AU - Sato, Takaaki
AU - Chida, Noritaka
N2 - The development of a two-step synthesis of multi-substituted N-methoxyamines from N-methoxyamides is reported. Utilization of the N-methoxy group as a reactivity control element was the key to success in this two-step synthesis. The first reaction involves a N-methoxyamide/aldehyde coupling reaction. Whereas ordinary amides cannot condense with aldehydes intermolecularly due to the poor nucleophilicity of the amide nitrogen, the N-methoxy group enhances the nucleophilicity of the nitrogen, enabling the direct coupling reaction. The second reaction in the two-step process was nucleophilic addition to the N-methoxyamides. Incorporation of the N-methoxy group into the amides increased the electrophilicity of the amide carbonyls and promoted the chelation effect. This nucleophilic addition enabled quick diversification of the products derived from the first step. The developed strategy was applicable to a variety of substrates, resulting in the elaboration of multi-substituted piperidines and acyclic amines, as well as a substructure of a complex natural alkaloid. Remote control: A two-step synthesis of multi-substituted N-methoxyamines including amide/aldehyde coupling and nucleophilic addition to amide carbonyls is reported (see scheme; TMS=trimethylsilyl). Incorporation of the N-methoxy group to the amides dramatically changes their reactivities, and enables quick access to diverse multi-substituted piperidines and acyclic substituted amines.
AB - The development of a two-step synthesis of multi-substituted N-methoxyamines from N-methoxyamides is reported. Utilization of the N-methoxy group as a reactivity control element was the key to success in this two-step synthesis. The first reaction involves a N-methoxyamide/aldehyde coupling reaction. Whereas ordinary amides cannot condense with aldehydes intermolecularly due to the poor nucleophilicity of the amide nitrogen, the N-methoxy group enhances the nucleophilicity of the nitrogen, enabling the direct coupling reaction. The second reaction in the two-step process was nucleophilic addition to the N-methoxyamides. Incorporation of the N-methoxy group into the amides increased the electrophilicity of the amide carbonyls and promoted the chelation effect. This nucleophilic addition enabled quick diversification of the products derived from the first step. The developed strategy was applicable to a variety of substrates, resulting in the elaboration of multi-substituted piperidines and acyclic amines, as well as a substructure of a complex natural alkaloid. Remote control: A two-step synthesis of multi-substituted N-methoxyamines including amide/aldehyde coupling and nucleophilic addition to amide carbonyls is reported (see scheme; TMS=trimethylsilyl). Incorporation of the N-methoxy group to the amides dramatically changes their reactivities, and enables quick access to diverse multi-substituted piperidines and acyclic substituted amines.


Trainer could rhyme with plainer - those socks are much more fun than ones that are plainer?! Or, I'll jump on the cross trainer- over Christmas it'll keep me saner?! Okay so I'm no better... Merry Christmas!
I'm liking this and may require your poetry skills in the future!! Merry Christmas Katie!!
Will somebody help me invest in a trainer, to speed up my running it's an utter no-brainer.


text:
Mongoose Traveller Adventure 1 - Beltstrike
This article originally appeared in the May 2013 issue.
Mongoose Traveller Adventure 1: Beltstrike. Lawrence Whittaker
softbound, 96pp
Mongoose's first complete adventure for Traveller sets a high standard for future adventures, blurring the line between 'adventure' and 'campaign'.
Beltstrike is written such that it does not depend on the Third Imperium setting; it depends on the Traveller Core Rules only. As a core adventure, it sports the standard black cover with Traveller-and-arrow logo; for adventures, the latter is a deep blue that is almost invisible against the black. The adventure carries the tagline "Face the Sonares Frontier", referring to the system in which the adventure is set.
Beltstrike is more than an adventure; it expands on the core rules by providing additional rules for detailing the composition of an asteroid belt and mining it, and for generating Belter characters. A section on equipping a belting expedition follows; all this can apply to belter adventures anywhere.
The adventure proper follows. This includes a section on the Sonara system, with a particular focus on the Schaffer Belt (where most of the action occurs), and a set of scenarios.
On Closer Inspection
The Sonara system is a developing society, but not quite up to FTL. Gear is limited to TL9, as are spacecraft, though the adventure describes two type of available spacecraft as matching the Type A Free Trader and the Type R Subsidized Merchant, but with cargo capacity increased and the jump drive omitted. Specifications and deck plans for a mining platform are provided, as well as for a 'seeker singleship' which looks like a variation on the Type S.
The initial scenario, "The Factory", serves to introduce the major players and key personalities. It includes a survey and evaluation of a mining platform. The platform turns out to contain secrets which the player-characters may or may not discover; these secrets can affect developments later on. There is also an option for the platform to have been occupied by pirates; if the referee takes that option, there is the potential for what should be a simple survey-and-evaluation to degrade into a dungeon crawl and pitched-battle scenario.
Once the survey is done, the adventure becomes a waiting game for the player-characters, and "Signals to Noise" provides several mini-scenarios that can be used to fill the time. "The Shoranan Habitat Run" involves shipping parts and equipment needed to rehabilitate the platform from "The Factory", and has some options for intrigue, ship-to-ship combat, and boarding actions. "Spindrift" offers the opportunity for prospecting and claim-jumping, if certain events transpired in "The Shoranan Habitat Run". "Factory Shadows" ties back to one of the secrets that might have been revealed in "The Factory". Finally, "Miscellanea" simply reveals a fact that can be used by the referee as a hook for additional adventures. There is no set order to these mini-scenarios, other than "Spindrift" being dependent on "The Shoranan Habitat Run".
Once the waiting game is over, it's time to actually repair the platform and recommission it. "Working Them Angels" provides a mechanic to simulate this, and also to potentially provide hooks for adventure sessions. This is essentially the entirety of "Resurrecting the Machine"; it also forms the backdrop to the mission in "Factory Online" and the events of "Rogan's Return".
Once the platform is recommissioned, "Adventures in the Chlaer Radical" establishes the pattern of 'business as usual' for a belt mining company, and provides a few mini-adventures that can be tossed at the players in any order.
Together, "Working Them Angels" and "Adventures in the Chlaer Radical" also present an enigma to hang further adventures on.
Finally, "Belt War" threatens the entire system with major upheaval, and the player-characters are positioned to be right in the thick of things, potentially making a difference in the final outcome.
Beltstrike sets a high standard for future core adventures; in the early days of Traveller, something this well-developed would be considered a campaign, rather than a mere adventure. Even played through to a conclusion—and there is plenty of opportunity to "get sidetracked" and take it in a different direction—the referee is left with plenty of hooks to hang further adventures on. This volume is unquestionably worth the money, and should be a part of every Traveller library.


It plays really well a lot of the time, and the game itself is action-packed and interesting enough to warrant looking past its problems.
Little has changed since the last time we saw this action game.
See Sony's new PlayStation 2 shooter in action.
No forum topics for SkyGunner yet. Want to start us off? Create a new topic.


text:
Коста Групчевић (Охрид, 1848 — Цариград, 3. фебруар 1907) је био Србин, национални и културни радник Јужне Србије, заслужан за јачање српскога утицаја у поробљеној тадашњој Македонији.

Ране године
Коста је рођен 1848. као најмлађи син у породици богатога охридскога терзијског мајстора (кројача). Родитељи Анђелко и Катарина, почивају у цркви Свете Богородице у свом родном месту. Прво је учио школу код охридског учитеља Григорија Прлинчевића, док овај није прешао у Дебар. Образовао се ту на грчком језику, док није напунио 16 година. Уз очеву финансијску подршку једно време боравио је у Бечу. По повратку у Охрид, заједно са браћом бавио се ћурчијским послом и трговином, која је увек била пуна стране штампе. У радионици се створила атмосфера као у читаоници, и ту свраћали многи па и Турци, да им Коста преводи оно што пишу грчке новине. Због његово слободоумности и народних окупљања, постао је сумњив властима - дошло до сукоба са Турцима, па је 1885. године напустио је Охрид. Касније није могао да се врати због Бугара егзархиста.

У бугарском затвору

У време када су трвили Грци и Бугари, у окриљу својих у Турској, привилегованих "егзархата", Срби нису имали излаз; Групчевић се тако приклонио Бугарима. И једни и други су преко својих црквених организација, подредили себи све (и српске!) школе у Јужној Србији. Бугарски националисти су деловали перфидније, вршили бугаризацију под паролом "За Славјанство". Отишао је Групчевић у Софију, где се убрзо одвојио од црквених егзархиста, и определио за "народоносну матицу". Био је у Бугарској једно време члан тајнога македонскога комитета. Разочаран у бугарску акцију стигао је у Цариград, одакле се са намером усмерава на Србију. Током 1886. године, након завршетка српско - бугарског рата, дошао је у Београд, где је од српског председника владе Милутина Гарашанина добио налог да се потруди да Македонија никако не постане бугарска. Нови српски посланик у Турској, Стојан Новаковић га је позвао да иду заједно у Цариград, где намерава да га ангажује као сарадника. Групчевић није послушао Новаковића да путују заједно преко Румуније, већ се сам упутио преко Бугарске. Док је путовао "својим послом" према Цариграду, Бугари су га у јесен 1886. ухапсили, под оптужбом да је будући "русофил" - руски шпијун. После тромесечнога затвора, пуштен је на условну слободу због јакога рускога и српскога притиска на бугарске власти. Побегао је априла 1887. из Бугарске у Румунију, а одатле у Цариград.

У Цариграду
У Цариграду се јавио српском конзулу Стојану Новаковићу, где је ангажован али без званичних задужења. Стално је приман у Васељенској патријаршији (као добар зналац грчког језика) и српском посланству у Цариграду, у оквиру поверљивих мисија. Сматрали су га великим противником пропаганде коју врши Бугарска егзархија у Македонији. Сматрало се и да је његова заслуга што су Срби добили две епархије (рашко-призренску и скопску) и два митрополитска места. Говорило се тада у Цариграду у "Фанару": "Групчевић прави владике". Радио је на отварању српских школа у Јужној Србији, под турском влашћу. Од 1892. године управљао је Групчевић централном цариградском српском књижаром, која је снабдевала све остале српске књижаре у Турској. У Цариграду је од 1889. до 1897. штампано 17 уџбеника за српске основне школе. Залагао се за македонску индивидуалност, а за македонске Словене је говорио да су Срби. Пошто је знао за огроман значај просвете, залагао се за штампање књига и уџбеника, поред текста на српском, да је у њима делимично заступљен и онај на "локалном дијалекту", да би их народ лакше прихватао. Одбачен је његов предлог да се просто у тексту измеша савремени српски језик и локално јужно наречје. Године 1889. активно сарађује у српском народном календару "Голуб"-у, намењеном тамошњем становништву. Због велике потребе да се писањем бране српски интереси у Турској, насупрот бугарској пропаганди, покренут је о трошку српске владе 1895. године "Цариградски гласник", тамошњи српски недељни лист. Уредник тог гласила био је Никодије Савић српски новинар из Пећи, а администратор (и каснији власник) Групчевић (из Охрида). Након Савићеве смрти, од 1897. до 1907. године био је Коста власник и издавач тог српскога недељника, који од тад излази у проширенијем обиму. Групчевића је српски краљ 1898. године одликовао орденом Св. Саве IV реда. За "Цариградски гласник" се каже (1907): "који има неоцењених заслуга за српство у турској царевини". Када је тај српски лист славио десетогодишњицу трајања 1905. године, Коста је био и његов пети по реду уредник (од 1897). Проживео је излашење листа непрестано бдијући над његовим опстанком, док су се уредници неколико пута мењали.

Коста Групчевић је објавио свој обимни рад о Охридском језеру и Охриду, који је имао туристички значај. Током 1888. године Групчевић је превео буквар на тадашњи "јужни локални дијалекат". Тај буквар је током 1899. штампан у 6.000 примерака, а 1891. у 10.000 примерака.

Епилог
Умро је као исцрпљен и истрошен национални радник Коста Групчевић, у Цариграду почетком 1907. године, и сахрањен на гробљу "Шишли". Некролог су објавили српски листови, попут Карловачког "Српског сиона". Породица је живела у сиромаштву, јер се он сав предао националној мисији. Био је ожењен Јевросимом Гавриловић из Охрида, тетком српског министра Панте Гавриловића. Изродили су супружници Групчевићи, двоје деце: Фани(ја) Групчевић је радила као зубни хирург у Охриду, а син Димитрије Групчевић био чиновник Министарства иностраних дела у Београду, саветник за руску емиграцију (1932). Димитрије је 1927. године био генерални конзул, а 1940. године становник Велеса и то као пензионер, политичар Земљорадничке странке. Године 1914. скупљани су прилози за Српски народни инвалидски фонд "Свети Ђорђе" у Охриду. Међу бројним дародавцима је и Костин сродник, Ђорђе Групчевић
тамошњи трговац са 15 динара прилога.

Референце

Спољашње везе
 Матица српска Одабране биографије том 1

Историја Македоније у новом веку
Стара Србија
Охриђани
Срби у Македонији
Срби у Турској

redpajama_set_name: RedPajamaWikipedia


text:
Father Antonio Demo  (April 23, 1870 – January 2, 1936) was a New York City Italian American priest and civic activist.

He studied at seminaries in Italy and entered the Scalabrini Order in 1894. Prior to his ordination, Demo served in the Italian military. He was ordained a priest on July 20, 1896, the same year he emigrated to the United States. He initially did missionary work for two years in the parish of the Sacred Heart in Boston, which served a congregation of Italian immigrants mostly from Genoa. On July 19, 1899, he was assigned as assistant pastor of Our Lady of Pompeii Church, established in 1892 by Father Pietro Bandini in New York City's Greenwich Village on Bleecker and Carmine Streets. In 1900 he was appointed pastor of the church, which served what was then one of largest Italian-American communities in America.

Father Demo exercised his apostolate among the Italian immigrants, serving until 1923 also as the director of the St. Raphael Society for the Protection of Italian Immigrants, an organization that had been specifically formed in 1891 by Bandini to assist newly arrived immigrants and that he helped to strengthen. His spiritual care and leadership were put to test on March 25, 1911, when he had to respond to the tragic Triangle Shirtwaist Company fire, which claimed the lives of 146 female employees. Because of his many merits in the care of the Italian community  he was decorated with the "Cross of Knight of the Crown of Italy".

In 1923 Father Demo learned that the church would have to be demolished to allow extension of the Sixth Avenue. Father Demo organized a campaign to buy a nearby property and with the help of a leading Italian American architect, Matthew Del Gaudio, build a new church and rectory. The new church was available for the congregation in May 1927. In late Summer 1931 the parochial school also was opened.

In 1935 Father Demo became Pompei's pastor emeritus and superintendent of its parochial school. He died in 1936 in Greenwich Village in New York City, and thousands of parishioners and friends, including Mayor Fiorello La Guardia, paid their respects.

In 1941, the intersection of Bleecker Street and Sixth Avenue was named Father Demo Square. In 2009, after a renovation, Father Demo Square was honored with a Village Award by the Greenwich Village Society for Historic Preservation.

References
Notes

Bibliography
Brown, Mary Elizabeth. "Italian Immigrant Catholic Clergy and an Exception to the Rule: The Revered Antonio Demo, Our Lady of Pompeii, Greenwich Village, 1899-1933."  In Church History 62.1 (March 1993): 41–59.
Falco, Nicholas Joseph. "Antonio Demo." In The Italian American Experience: An Encyclopedia, ed. Salvatore J. LaGumina (New York: Garland, 2000), 177–78.

External links
 Biography of Father Demo
 Scalabrinians Official Website
 Our Lady of Pompeii Church

1870 births
1936 deaths
Italian emigrants to the United States
Religious leaders from New York City
Scalabrinians
History of Catholicism in the United States
19th-century American Roman Catholic priests
20th-century American Roman Catholic priests


Size: 1 volume/box; 0.4 cu.ft.
This collection consists of a scrapbook containing newspaper advertisements for the Graham Ice Cream Company of Norfolk, Nebraska. The advertisements date from ca. 1922-1929. For preservation purposes, the scrapbook pages have been removed from their binding and placed in folders.


If a service provider of your contractual partner (e.g. transport company, hotel, car rental company, local travel agent, etc.) questions the validity of your travel documents during your trip, insist that it provide the services paid for by you unconditionally. As a rule, the partner is obligated to do so, regardless of whether it has already been paid by your contractual partner for the services to be provided or not.
If there are any problems, contact the local representative of your contractual partner stated in the travel documents. In addition to the local tour management or representative, there is often also an international 24/7 hotline of your contractual partner.
Under certain circumstances, a representation of a different Swiss tour operator may exist at your destination of travel (most of them are members of the Guarantee Fund) which can help you in coordination with our office.
In an emergency, you can contact the office of the Guarantee Fund at normal working hours for advice.
Your contractual partner must, however, compensate you for the service paid for by you but not provided by the partner or service providers tasked by it. For this reason, first contact your booking office or contractual partner in any event.
If your contractual partner is a member of the Guarantee Fund, the payments you have made for a package tour are insured by the foundation. If your contractual partner becomes insolvent or bankrupt before departure, the amount paid is refunded by the foundation or the trip is carried out by the foundation via a third party. If the insolvency or bankruptcy occurs after the embarking on your journey, the Guarantee Fund will cover the costs for the return trip if the service provider/s have not fulfilled their obligations on site.


text:
Home Basket Ball 4 Most Controversial Moments in NBA History
4 Most Controversial Moments in NBA History
Source: sportingnews.com
Basketball is a very popular sport around the world and one that people love to get involved with. This can be as a competitor on the court or as a coach off it. If you like to coach basketball, it is always a good idea to be researching new ideas to bring to the table or ways to help your players improve. A good way to do this is looking online for help or even studying pro games to see what strategies top coaches use.
In terms of watching basketball for fun or to get tips as a coach, the NBA is still the first place to head. As the sport's premier competition, it features the best sides and the best players to follow. It is also a great league to bet on, if you like to have a wager now and then. A good tip for sports bettors with this in mind is finding the top bonus offers to take advantage of.
This is true whatever sport you bet on, and a good general tip to take on board. Football is a great example and there is more information at thegameday.com about how bonuses work in NFL betting. Once you have got to grips with this, the same principles apply to using bonuses in NBA betting too.
Many fans also love following the NBA because of the drama and controversies it throws up sometimes. But which are the most shocking to know about?
1. The Malice at the Palace
Source: theguardian.com
It is pretty safe to say that, for many, 2004's Malice at the Palace is the most controversial moment in NBA history. But what actually happened?
This controversy took place during November 2004's game between the Detroit Pistons and Indiana Pacers. At the time, the Pistons were defending champions and hosting the Pacers at the Palace in Auburn Hills, Michigan. The trouble began when Pistons center Ben Wallace tried a layup shot, with just 45 seconds left, to drag his team back into the game. Wallace, though, was fouled by the Pacers Ron Artest and a fight soon broke out on court between the teams.
It was what happened after this that leaves this moment in NBA history so infamous. While Artest was calming down from the brawl, a Pistons fan threw a drink at him from the stands. Artest lost his cool and charged into the stands to confront the fan. This started another brawl, involving fans and players from both sides.
2. Knicks and Nuggets brawl
Source: sportscasting.com
While information like the 10 best basketball socks is always good to know, there is nothing like digging into the drama buried in the sport's past. Another highly controversial moment is this fight between the Denver Nuggets and New York Knicks. This happened in a match between the sides in December 2006 – it's fair to say that not too much festive cheer was on show at the time!
The Knicks were hosting the game at Madison Square Garden and all seemed to be pretty normal going into the last few seconds. An obvious foul by Knicks player Mardy Collins, though, on J.R. Smith of the Nuggets soon changed that! Several players from each side squared off and things got physical. This trouble made its way into the stands, where fans began fighting as well. All 10 players were ejected from the court at the time and seven players were suspended without pay afterwards, for a total of 47 games.
3. Tim Donaghy scandal
Source: basketballforever.com
Although many controversies in the NBA focus on on-court drama, this is not always the case. The scandal around former NBA ref Tim Donaghy sums this up perfectly. Although a seasoned and respected official, Donaghy was actually busted for gambling on games and manipulating game outcomes to win these bets! To make matters even worse, it was reported that he did all this while working for the Mafia.
But how did this all come to light? In 2007, the FBI started to investigate a then-unnamed NBA official, due to allegations they had heard about gambling on games he had officiated previously. The investigation not only proved these allegations to be true but also confirmed that Donaghy had used his knowledge of other official bias against certain players and teams to win other bets.
Interestingly, despite NBA Commissioner David Stern insisting this was a one-off case, Donaghy maintained otherwise. He claimed that the majority of NBA refs bet on games and that officials used bad calls to keep games close, in order to extend playoff series.
4. The frozen envelope and Patrick Ewing
Source: sportsnet.ca
The aforementioned David Stern is something of a divisive figure for NBA fans and his name seems to come up a lot when there are allegations of misconduct. This stretches back a long way – even to the 1985 Draft lottery, for example!
In 1985, Patrick Ewing was the number one pick in many people's eyes and an obvious superstar in the making. Coming into the draft lottery, the Sacramento Kings had the highest odds of claiming first pick because they had most envelopes in the draw. In turn, this meant they had the best chance of getting first pick and bringing Ewing to their side.
However, this did not happen and many NBA fans to this day still find it a controversial moment. Rumors are that Stern did not want Ewing to go to a small-time side like the Kings and instead wanted him to become the face of NBA at a more well-known team. Speculation followed that officials froze the envelope belonging to the Knicks, so that Stern could easily tell it was theirs when pulling it out. Although we do not know if this is true, we do know that the Knicks' envelope was pulled out first by Stern, and they bagged Ewing.
NBA has seen some major controversies
There is no doubt that the NBA is basketball's premier competition. It is also without doubt that it has seen some major controversies over time. Luckily, these are not regular occurrences and the NBA is normally a place where the focus is firmly on the talent of the players or coaches. With this in mind, finding ways to improve as a player or coach is a great pursuit.
Controversial Moments
Patrick Ewing
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possess the knowledge, ideas and pride that form a tight bond between them and their nationality. We do believe that a beauty queen is a role model for the entire society. That is why our goal is to choose a queen who the younger generation, her nation, and the entire world can look up to. Regardless of their religion or ethnicity, the contestants have a high level of national awareness and care about their mother tongue. They have a thorough knowledge of their country's history and geography and are familiar with national customs and traditions. They are family-centric and interested in local gastronomy.
imposed by the Contest Regulations.
The contests are first held within national settings. Thereafter, beauty queens represent their countries and values in the international contest. It is important to emphasize that this contest is not only about looks, but also about national awareness, without which there is no true beauty queen.
The first strategic step in organising the national contest is making the public aware of Miss Nation's Beauty through advertising and social media. Social media has the advantage of not only being an ad platform, but also serving as an information channel, and can help build brand identity. Participating countries are highly advised to be present on both Facebook and Instagram, but the global Miss Nation's Beauty social media accounts can be referenced as well, as they are the mutual online platform of all hosting nations. Important deadlines should be clearly communicated via social media; regular posting and engagement of the online community is advised to raise and maintain awareness. Countries should have their own contest websites, but www.missnation.eu covers all relevant information of participating nations, and can be referenced at all times.
Our Contest Regulations defines the application age limits as 21 and 27 years. We consider that the lower limit of 21 years is justified by the fact that, in our opinion, girls younger than that would find it more difficult to handle the popularity resulting from getting the crown; only an adult woman can confidently follow through on the commitments and handle a journey of constant exposure. Height, physique, face, hair and smile may differ nation by nation, though always following the standard trend. The way to the final includes several challenges. Contestants should be selected in preliminary rounds. The advantage of the Miss Nation's Beauty contest is that girls of not only a country but of an entire nation may apply to the contest held in the mother country, independently of their place of living, bridging over borders. The simplest way of recruiting girls for the contest is to offer online application.
This, of course, has to be advertised on several forums, like Facebook, Instagram and different media channels. Besides providing their personal details (height, weight, age and, naturally, contact information /email, postal address and phone number/), applicants must attach several photographs to their application. The website contains an option, which automatically imports the photos and details of applicants into a system. The point is for incoming registrations to be pre-filtered by the office, after which potential candidates receive the venues and times of preliminary rounds. During the preliminary rounds, contestants appear before the professional jury also in bathing suits. In the final round of the contest, there is no bathing suit tour, to protect the elegance of the event. In protection of the contest, the bathing suit tour has been cancelled. We cannot allow it at the contest gala as we consider it would be unworthy for the most beautiful girls of nations. Our other criterion at the Miss Nation's Beauty international contest is naturalness. Nowadays, most healthy and beautiful girls undergo plastic surgeries already at a young age, which has become a sort of norm. We are strongly against this trend and, for this very reason, would like to emphasize with the candidates who reach the final that naturalness is more important than anything else – and this is the message that our queen also promotes to society. Real values, inner harmony and uniqueness are the factors that one can stand out from the crowd with and become the queen of a nation.
Depending on the number of applicants, there may be several auditions, in several regions. Ideally, a total of 16-18 girls should go forward from auditions, who participate in the oneweek preparation camp. As the main goal of the preparation camp is to identify the girls' real self and competence, it is recommended to set them tasks and challenges which can quickly find out about these aspects. Besides these, the preparation camp also prepares the girls for the gala evening, which is a high-standard, elegant show, which requires much preparation with regards to the girls' outer appearance and physical condition. It is strongly recommended to use the assistance of professionals (choreographer, fitness trainer, communication adviser, etc.) during the camp. It is advised to hire a permanently available staff for the compilation of the necessary reference materials (photographer, cameraman). Ten girls may advance to the final. The introduction videos of these ten girls must be shot during the camp. The compulsory elements of the final are the (intro) theme song, the cocktail dress tour and the evening dress tour. These are all choreographed elements, with carefully selected music. An entry in costumes decorated with national patterns is also recommended, which may take place as an additional element. However, a bikini tour is not allowed in any form. On the night of the final, it is advised to invite performers who represent elegance and can thus raise the event's standard further and are a match to the style of the night. During this event, playing folk and classical music is also strongly recommended. Finals must finish in April or May and, by the end of June or early July, the chosen queens must be ready for the international contest, where there will be several entries and each queen must bring with her a performance of her own. This performance should highlight the queen's skills and talent, so that the hallmarks of her nationality are also represented. Queens are expected to appropriately perform at the international final as they participate there representing a whole nation. It is, therefore, highly important for each country to carefully choose a queen who will meet these challenges.
Press conferences must be held about the events in the host cities of the nations, on the event days. The representatives of regional papers, dailies and weeklies, lifestyle magazines, women's magazines, online news and tabloid sites and regional television channels should be invited to these conferences. Each attendant will get a folder, which contains, besides the press materials about the event series, sponsors' introductions. At the press conference, sponsors' stands can be put on display and the representatives of the press may be given unique, creative gifts that promote the given sponsor's products.
Such sponsors are eligible who represent timeless values and outstanding quality. They may come from agriculture or the food industry; wineries, producers of meat or dairy products, makers of handmade products, bio-farms. Eligible sponsors also include players of the beauty industry, distributors of (bio) cosmetic products. They may also be companies operating in the construction industry, freight forwarders, firms from the energy sector, the chemical industry, electronics or transportation, which have an image associated with reliability and stability. The designers or creators of industrial, economic or technical innovations may also be potential sponsors.
* Establish cooperation with the municipal governments of the host cities, thus supporting the improvement of the region's tourist appeal and generation of revenues for the nation. The event's promotion campaign offers an excellent opportunity to show the given country's sights, attractions, monuments and traditions in photo and video materials. The media attention triggered by the event also improves the reputation of the country and the region and supports branding. The contest has a countrywide coverage; the continuous information flow during the auditions supports the development of a healthy competitive spirit between cities. An event series like this reaches masses of people and strengthens national identity. According to former experience, contestants who reached success in a television talent show brought to their cities the feeling of belonging together and their success triggered the strengthening of social values. The companies and investors arriving at the city for the event support networking and the reconciliation of interests and may generate revenues for the region in the future.
* Establish cooperation with domestic SMEs, farms, farmers, manufacturers and designers.
* Establish partnership relations with foundations and NGOs. On the one hand, the cause requires broad social collaboration, on the other, bigger media interest and awareness can be achieved by winning recognised organisations for the event.
* displaying the values of a nation – tourism, agriculture, industry, innovation, etc.
It is important to win well-known and recognised, successful people to be the faces of the event, ones who can authentically represent our goals. They will be the people who will comprise the jury, campaign for the event and encourage application. They will appear in the marketing campaign, give interviews and be anchor persons. They will play a part in the video clips, in the film clips and take part in the preparation camp. Recommended types of people: performers, models, actors and actresses, social actors, Olympians, people who have a message, whose presence is an event itself and who are known for standing up for different social causes.
trends with folk costumes, their shapes and patterns. The different designers' creations, the clothes worn in the different rounds display their national identity.
The message of the event will also be composed into a song, for which a video clip will be made. Besides, a country branding film clip or clip series will also be shot, in which tourist attractions and natural assets, elements of the agriculture and industry and, of course, the contestants, will be presented in typical national traditions, customs and activities. Viewers will get an insight into the history of the nations, the process of their development and the most novel innovations. The plot of the clip will take place on various sites, the most beautiful tourist attractions, presenting buildings, cities, waters and nature. The videos will be put on Youtube, they can be integrated into the website, the Facebook campaign, the LED-wall campaign and the electronic and online publications. The song can be played on radio channels, the clips can be broadcast in regional televisions and can be used by the television media supporter in the course of promotion. In the course of the auditions and the final, the videos, running in the background, will form the foundation of the events' visuals. In addition to all these, the entire process, from the auditions, will be recorded, and the face of the campaign, who represents the contest, will call people's attention to the event and application in video messages – the messages will together form a series, from the venues of the auditions and the camp, and share behind-the-scenes footage and interesting facts. These videos will also be put on Youtube, will form the basis of the content management of the Facebook campaign and will be a continuous subject of public discussion, thus generating more awareness. The videos will be recorded on data carriers and can be distributed as a gift among press representatives, contest visitors and VIP guests. The materials can also be used in the next year's campaign.
commercial radio channels. Much emphasis is laid on the social media (Facebook, Instagram, Twitter, etc.) as they can be used to easily reach the target audience, the campaign can be optimised at any time on the way and the prices of advertising are lower than on other electronic and online platforms.
The host country is responsible for the organisation of the final international contest and the five-day preparation camp that precedes it. During this camp, the queens arriving from different countries practice the choreography, the gala tour entries and costume fitting-ons. At the international contest, the clothes for the evening dress entry of the contestants will be provided by our exclusive partner, Silka Fashion. As the gala event will comprise several tours, the queens arriving from the different countries may also represent their nation by wearing national costumes. Between tours, celebrity performers and famous (television) hosts will raise attraction.
The event's elevated atmosphere and message requires exclusive venues like hotels, castles, theatres or outdoor stages built in the vicinity of tourist attractions.
The top contestants receive travels, cars, valuable objects, style trainings, modeling and acting trainings, language teaching and photo shoots. For a year, they promote the products/services of the sponsors and participate in ad campaigns. They also represent their nations in the international Miss Nation's Beauty contest.
starts with the support of sponsors (note: these sponsors can be different ones than the contest's), lead by the beauty queens. The queen herself must participate in the campaign, doing charity work and improving society. The outcome of the campaign is not the most important factor: the message is that when working together, everything can be achieved. In each country, the campaign will run under the "Miss Nation's Beauty" name, though partner's names supporting the cause will also be displayed.


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File under: Everything, Player Attack TV, Promoted October 28, 2011
playerttack News Season 2, Episode 37
playerattack News this week takes a look at the first shot fired in the big-name FPS stand-off of 2011: Battlefield 3. The launch was not without controversy, missing features, broken street dates, and a mysterious black card.
Meanwhile, Grand Theft Auto V has been confirmed, with more details on the way. The Metal Gear Solid HD Collection has been delayed, but only in some parts of the world, Ultima developer Richard Garriott has been replaced by a robot, and the Xbox 360 version of Minecraft won't quite make the PC launch. Temple of the Spider God brings Gamebook Adventures to a new generation, and an American aquarium company has a gamer in charge of naming coral.
playerattack News is a once-a-week wrap up of the biggest and most interesting news to hit the pages of playerattack. If you'd like to subscribe, you can do that via RSS feed, through iTunes, or if you'd prefer, subscribe to our YouTube channel.
Tags: Acanthastrea coral, Australia, Battlefield 1943, Battlefield 3, Call of Duty: Black Ops, Electronic Arts, Gamebook Adventures, Gamebook Adventures: Temple of the Spider God, Grand Theft Auto V, Konami, Medal of Honor, Metal Gear, Metal Gear 2: Solid Snake, Metal Gear Solid 2: Sons of Liberty, Metal Gear Solid 3: Snake Eater, Metal Gear Solid HD Collection, Metal Gear Solid: Peace Walker, Minecraft, n00b Tube, Nuketown, QB60, Quality Marine, Richard Garriott, Rockstar Games, Ultima, Xbox 360