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Queer Transitions
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Leeroy Kun Young Kang, Tara Mateik, Michelle Parkerson
The second program of the Flaherty NYC Winter/Spring series "Transforming Provocations" took place this past Tuesday, February 2nd, at Anthology Film Archives in Manhattan. The event was co-presented with Women Make Movies, and took on "Queer Transitions" as the theme, looking at the "history and [the] present of evolving erotic experiences of embodiment from defiant and empowering perspectives."
Filmmakers Tara Mateik and Michelle Parkerson were also present for a post-screening conversation, moderated by visual artist and independent curator Leeroy Kun Young Kang. Artists Lana Lin and Cauleen Smith programmed this season's Flaherty NYC series, and selected six shorts for screening on Tuesday: All Women Are Equal (Marguerite Paris, 1972), Storme: Lady of The Jewel Box (Michelle Parkerson, 1987), Boy Frankestein (Susana Donovan, 1994), Layer (Ruth Jenrbekova and Maria Vilk, 2015), Maku (Yoriko Mizushiri, 2014), and Operation Invert (Tara Mateik, 2003). "Through their interventions, the filmmakers offer critical and comedic commentaries on gender normativity. Their films are world-making efforts that help us imagine unbounded intimacies where gender is fluid and gender non-conformativity de-pathologized," – Lana Lin and Cauleen Smith.
Lana Lin, Michelle Parkerson , Leeroy Kun Young Kang, Tara Mateik,
All films are diverse in terms of presentation and subject matter, carefully tackling "transitions" as an encounter relevant across life experiences. Maku, for example is an animation short that tries to visualize internal feelings, while juxtaposing this experience with metaphorical physical senses, Boy Frankestein forms a lyrical critique on the nuclear family and individual perception through film collages, while All Women Are Equal profiles a transgendered person in 1972 Nottingham England in black and white. Layer, on the other hand, is an amateur-style, comedic, visceral mockumentary from Kazakhstan, that chronicles around the protagonist's coming-out as an "oviparous person," and contextualizes transgender life in oppressive societies.
Leeroy Kang, during the post-screening discussion said, the idea of "transitions" is a compelling concept, and that the program "has a very international perspective, varied in terms of time period, [and] in forms and aesthetics." While many may associate the term "under transition" with the transgender experience in the queer discourse, Kang extended this idea to other more commonly discussed experience, but not often regarded as a form of "transition" – child to adult transition, political and historical transition, media transitions, and human forms transitions – and how all these transitions also affect the queer experience.
Michelle Parkerson's 21-minute long documentary Storme: Lady of The Jewel Box, on the other hand, profiles Storme DeLarverie, a biracial woman, and also a mistress of ceremonies and sole impersonator of the legendary Jewel Box Revue in the 50s and the 60s. She was also one of many that fought the police in the 1969 historic riot at the Stonewall Inn in Greenwich Village. As Parkerson delved into filmmaking in college in the 1980s, she vowed to document women of color's experience. Her inclination to profile DeLarverie during that time was "natural," Parkerson said at the post-screening discussion, "as my sexuality was developing, and having come out at 19, things were in the mix of the salad bowl of evolution." Parkerson also attributed her inspiration to her childhood interaction with her mother, who was a devout Christian, but who was also very intrigued by the only woman who impersonated man in The Jewel Box Revue – who indeed, was Storme DeLarverie.
In Operation Invert, filmmaker Tara Mateik humorously and critically compared different regulations mediating botox-related plastic surgery and gender re-assignment "sex change." Around the same time Mateik got top surgery-a double mastectomy,the FDA approved the use of botox, a classified "weapon of mass destruction", as a cosmetic drug. "It's not just a thing for trans people – shifting, and changing, and transitioning," said Mateik. Through pictures, texts, and self-portrait shots, Mateik looks at the double standard of "transitions" – how cosmetic surgery used to heighten your gender is acceptable, but when it is used to confuse one's perceived gender, then one's sanity may be ascertained.
Join us on Tuesday, February 16th, at Anthology Film Archives for Flaherty NYC's third program this season, "REGIME CHANGE," where eight shorts will be screened. Filmmaker Beatriz Santiago Munoz and Akwaeke Emezi will be present for a post-screening discussion. This series is made possible through collaboration with The New School.
-Rahmah Pauzi
Flaherty Winter/Spring Intern
Tuesday, February 2, 7:00pm @Anthology Film Archives
Programmed by Lana Lin & Cauleen Smith
This series is made possible through a collaboration with The New School.
Screening co-presented with Women Make Movies
Filmmakers Tara Mateik and Michelle Parkerson in person for a post-screening discussion with archivist and independent curator Leeroy Kun Young Kang.
This program looks at a history and present of evolving erotic experiences of embodiment from defiant and empowering perspectives. Each film originates from and reflects upon a specific queer time and space: the Black theater circuit of the 1950s and 60s, England in the early 1970s, present day Kazakhstan. Through their interventions, the filmmakers offer critical and comedic commentaries on gender normativity. Their films are world-making efforts that help us imagine unbounded intimacies where gender is fluid and gender non-conformativity de-pathologized.
All Women Are Equal
Directed by Marguerite Paris
(1972, 15 min, 16mm)
Filmed in Nottingham England by veteran lesbian filmmaker, Marguerite Paris, this very early and non-exploitative representation of an ordinary well- adjusted transgendered person is historically significant for its treatment of the subject. Also unique is that Paris produced, directed, shot and edited this film, which, unlike their other representations, allows Paula, a male to female transsexual, to tell her own personal story, without resorting to spectacle. Through Paris's lens, we see Paula fixing her make up and discussing the difficulty of living as a woman and meeting other trans people. The film offers insights into both the time and Paula's individual psyche.
Storme: The Lady of the Jewel Box
Storme: Lady of the Jewel Box
Directed by Michelle Parkerson
(1987, 21 min, 16mm transferred to DVD)
During the 1950s and 60s Storme DeLarverie toured the Black theater circuit as a host and the sole male impersonator of the legendary Jewel Box Revue, America's first integrated female impersonation show and forerunner of La Cage aux Folles. The multiracial revue was a favorite act of the Black theater circuit and attracted mixed mainstream audiences at a time marked by the violence of segregation. Parkerson finds Storme in New York's Chelsea neighborhood, now working as a bodyguard at a women's bar and still singing in her deep silky voice with an "all girl" band. Through archival clips from the past, STORME looks back on the grandeur of the Jewel Box Revue and its celebration of pure entertainment in the face of homophobia and segregation. Storme herself emerges as a remarkable woman, who came up during hard times but always "kept a touch of class."
Boy Frankenstein
Directed by Susana Donovan
(1994, 9 min, digital)
Using collaged images, text and narration, Boy Frankenstein forms a lyrical critique of the limitations and destructive propensities of the nuclear family–as it relates the story of an individual constructed entirely by the comments and perceptions of those around her/him.
Directed by Ruth Jenrbekova & Maria Vilk
(2015, 21 min, digital)
Layer is a "no budget" amateur style mockumentary short. Its protagonist tells a story of her life-long coming out as an "oviparous person." The video incorporates some sci-fi elements (concerning human oviparity) with its depiction of everyday life within the largest city of Kazakhstan. Through its use of humor and the quotidian, human oviparity as a mark of radical difference can be seen in relation to the demonization of transgender life in oppressive societies.
Maku (Veil)
Directed by Yoriko Mizushiri
Kyogen Stage/Eye Examination Room/Sushi Bar Counter. There are two people who face each other in each space. Each pair keeps a little distance between their partners and finds some fearful, tender, and comfortable feelings that fascinate them. The feelings are put into practice immediately, and they start groping each others feelings. "Feelings" are sound bliss for all who have a body and sense. Somehow, I try to blend and connect them. I busily pick my feelings from the track of my life and reconstruct by animation to appreciate them.
Operation Invert
Directed by Tara Mateik
Are gender outlaws considered the new biological terrorists seeking weapons of mass bodily destruction? This video draws a comparison between the widely available cosmetic treatment Botox and the role of medical and psychiatric professions in allowing female-to-male top surgery, revealing a connection to the war on terror and to outdated medical assessments. Historical medical assessments of the invert (homosexual and transsexual) "condition" are rooted in seemingly outdated absurdities about outsider deviance. Nevertheless, current institutional loopholes governing gender re-assignment surgery suggest a fresh resurgence of loony pathologies and diagnoses. You can use cosmetic surgery to heighten your gender and reduce signs of aging by injecting a toxic poison in your face, but if you decide to use cosmetic surgery to confuse compulsory gender, your sanity must be professionally ascertained.
FILMMAKERS:
Born in Brooklyn, Marguerite Paris (1934-2007) studied dance and acting in the early 1950s. In 1967, she began shooting films and sat in on Ken Jacobs's classes at the Millenium Film Workshop. She credits Jacobs as "the person who enlightened me as an artist." Paris's work has been exhibited at the Berlin Film Festival, the Museum of Modern Art, MIX: New York Lesbian and Gay Experimental Film Festival, the San Francisco Lesbian & Gay Film Festival, Hallwalls, Anthology Film Archives, and the National Film Theatre of London.
Michelle Parkerson is an award-winning filmmaker based in Washington, DC whose work has screened at the Sundance Film Festival, the Berlin International Film Festival and the American Film Institute. She has documented the lives of LGBT icon, Audre Lorde ("A LITANY FOR SURVIVAL"), jazz innovator Betty Carter ("…BUT THEN, SHE'S BETTY CARTER"), international acappella activists, Sweet Honey In The Rock ("GOTTA MAKE THIS JOURNEY") and legendary male impersonator, Storme DeLarverie ("STORME; THE LADY OF THE JEWEL BOX"). She is currently scripting a 1920's action-adventure entitled, "LIFTED", telling the phenomenal story of Miss Bessie Coleman, the first Black woman pilot.
Susana Donovan, a native of California, attended San Francisco State University (M.A., 1994). Her jury awarded work has screened internationally. Boy Frankenstein was included in the 2001 Whitney Biennial, the First International Transgender Film and Video Festival, London, England, and the New York Video Festival. Currently, Donovan is writing a graphic novel.
Ruth Jenrbekova, born in Alma-Ata, Kazakhstan, in 1973. Graduated from Kazakh State University in 1995 (biology, ecology). Additional education includes literary school "Musagetes" (Almaty) and curatorial summer school (Moskow). Main interests concern cultural creolization, trans identities and performance art as a means of transformations. Representative of fake art-institution named "Creoleak Centr". Author of texts, lecturer, performance and sound artist. Lives and works in Almaty.
Maria Vilkovisky, born in Alma-Ata, Kazakhstan, in 1971. Graduated from Kazakh State Conservatory in 1996 (viola). Additional education includes literary school "Musagetes" (Almaty) and curatorial summer school (Moskow). Combines performative, literary and curatorial activities, often on behalf of fake art-institution named "Creoleak Centr". Poet, musician, performer and curator. Lives and works in Almaty.
Yoriko Mizushiri was born in 1984 in Aomori prefecture, Japan. After obtaining a BA in Design at the Joshibi University of Art and Design in Tokyo, she has been living and working as a freelancer in Tokyo. Apart from animated film works, she also produces gallery exhibitions from time to time. Her film FUTON won prestigious Japanese prestige awards, including the Renzo Kinoshita Prize (Hiroshima International Animation Festival) and New Face Award (Japan Media Arts Festival), and has been applauded and nominated/awarded at numerous international film festivals. Her following films KAMAKURA and MAKU have been nominated at Berlinale for two consecutive years.
Tara Mateik creates critical reenactments that underscore moments of collective transfeminism across historical and geographic locations. He works with queer iconography to explore the ways in which history is written on, and by, actual bodies. Performing with other gender nonconforming bodies, his videos, performances, and installations are intended to disrupt participants' expectations, to present the imaginable as real, and to generate new political potentialities—in essence, to pervert the audiovisual archive. Mateik's work is distributed by The Video Data Bank and has been exhibited at various domestic and international venues (MoMA PS1, The Solomon R. Guggenheim Museum, The Kitchen, Participant Inc., Reena Spaulings, Aurora Pictures [Houston], and the Oberhausen Short Film Festival [Germany]). He is a Franklin Furnace Fund Award (2013) and Creative Capital Film/Video Award (2008) recipient and Assistant Professor in the Department of Media and Culture at the College of Staten Island/CUNY.
Leeroy Kun Young Kang is an archivist, independent curator, and visual artist whose work lives in the intersections of legacy audiovisual preservation and access, experimental Asian Pacific film and video, and queer and transgender history and visual culture.Kang's archival work includes collections at the New Museum, Brooklyn Academy of Music, MTV Networks, and the New-York Historical Society. His video work has screened internationally at various venues including CAAMFest, Human Resources Los Angeles, MIX NYC, and Studio 2224 in Taipei, and he has curated programs for the Los Angeles Asian Pacific Film Festival, Dirty Looks NYC, and CLAGS: The Center for LGBTQ Studies. He holds a BA in Studio Art from UC Santa Barbara, an MLS from Queens College, and is currently a visiting scholar at the Asian/Pacific/American Institute at NYU.
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Do you want to dress like Ariel?
So first, we will analyze Ariel's character and personality for clues about her style personality–so we can create an outfit that's deeply inspired by her.
Then after that, we'll look at what she has actually worn and break it down into various aspects, to gain ideas of how we can re-create or gain inspiration from it.
We will be analyzing through using 8 aspects of costume and character design, which are explained in my post How to Analyze and Recreate a Character-Based Outfit.
*This post contains affiliate links. This means that if you click on item links to make a purchase, i will earn a small commission, at no extra cost to you. I hope you enjoy browsing my picks, reading this post, and find some inspiration!
Just look at all those interesting mermaid hairstyles! Ariel looks casual in comparison, but she's also the only one who's daring enough to play with color contrast.
Ariel seems to have few–if any–comfort zones…She seems to constantly live outside them as she strives toward what she wants. Especially when it comes to her desire to be part of the human world. The only moment i can really recall her being discouraged was when "Vanessa" stepped into the picture, nearly stealing Eric away. She sat in defeat, surely feeling like she over-estimated herself, probably feeling a sudden sense of worthlessness–until realizing that Vanessa is actually Ursula in disguise, which made her rush back to action.
With this go-for-it attitude, i don't think it would be crazy to say she'd likely be a dauntless trendsetter, ready to be the first to take on the latest, greatest and craziest styles (especially if they're human styles), or set new ones or reclaim older ones herself.
Female, Caucasian, redhead, mermaid-gone-human. Her gender and ethnicity aren't a huge part of her story, so she can easily be gender- or race-bent. The mermaid aspect of herself though, which is a huge part of her story, can fairly easily be represented in costume, with the use of scale-prints and ocean-themed items–such as shells.
Princess Ariel is the 7th and youngest daughter born to King Triton and Queen Athena of Atlantica. Her mother was killed by pirates (according to the prequel), to her father's greatest devastation, while the family was enjoying time above the waves.
Ariel has a fascination with the human world which led to her collection of human objects held in her secret grotto, which were largely collected from shipwrecks. One particular shipwreck adventure nearly got her and Flounder killed by a shark–but she remained almost nonchalant and quick-witted in fending off the shark, though Flounder was scared out of his fins. Afterwards, our armchair-anthropologist, Ariel, brought her findings to her rather incompetent teacher, Scuttle, who taught her the uses of her new "human stuff": the "Dinglehopper", a hair straightener and brush (fork) and the "Snarfblat", a musical wind instrument (smoking pipe).
In the excitement of her adventure, she forgot about the concert she was supposed to sing in–this got her in trouble with her father, and in Flounder's defensiveness it was accidentally made known that she had visited Scuttle above the waters, again, getting her in more trouble–her response was to swim off in frustration at her dad's lack of willingness to understand. Sebastian was sent to look after her, from now on, and was therefore made aware of her grotto and obsession with the human world growing stronger, to the point of her longing to experience the human world for herself, as she sung Part of That World.
Ariel swam back up to the surface upon seeing a ship over her grotto and watched the fireworks and Eric's party in admiration and pure delight. She became enamored at the sight of Eric. A storm took down the ship, and Ariel rescued a near-drowning Eric from the wreckage.
Ariel's now giggly, daydreamy, singsongy, ecstatic, and romance-struck self became clear to her sisters and then her father, who inquired Sebastian about her new love-interest…anxiously, Sebastian eventually burst out about Eric–an unwelcomed surprise. Triton found her grotto and ended up destroying everything in an attempt to get through to her. She was left devastated and angry.
Despite knowing that accepting help from Ursula was a bad idea, she eventually gave in and stuck firmly to that decision, though she was afraid. The deal was made: Ursula would turn Ariel human, giving her three days to get Eric to lovingly kiss her, at the cost of her voice…And if she were to fail, she'd belong to Ursula as a new addition to her garden of polyps.
Her friends rescued her from drowning, and Scuttle created her first dress out of a ship's sail. Eric's dog, Max, found her and brought Eric who vaguely recognized her, but doubted himself when he realized she can't speak. Eric brought her back to his castle out of sympathy, where she was bathed and dressed in a pink gown for dinner.
At the table, she excitedly used the "dinglehopper", only to get embarrassing, confused stares in return, but she immediately and resiliently became thrilled once again at the sight of Grimsby's "snarfblat", taking it and blowing it into his face, to Eric's humor.
Ariel peacefully drifted to sleep, excited about the following day, even while Sebastian worriedly continued on with advice and concerns. Eric took Airel out for a tour of the kingdom, just the two of them. They explored, danced and shopped, and Eric allowed Ariel to wildly and fearlessly drive the carriage. Their day out ended with a boat ride in an atmospheric lagoon where Eric tried to guess her name and, with Sebastian's musical help, they nearly kissed, but Flotsam and Jetsam tipped the boat.
The following morning, Scuttle brought news that Eric is getting married–Ariel excitedly ran downstairs, assuming she would be the bride, only to discover Vanessa with Eric, discussing wedding plans with Grimsby. Ariel ran off crying and spent her time sulking as she watched Eric's wedding boat depart.
Scuttle alerted Ariel that he discovered Vanessa is actually Ursula in disguise, she quickly dived into the water, though she no longer knew how to swim because of her new human form. Sebastian and Flounder helped her swim with the aid of wooden barrels. Scuttle broke Ursula's necklace, Ariel's voice was released, and the spell was broken from Eric. Ariel and Eric nearly shared their first kiss, but Ariel transformed back to her mermaid self and was dragged back to sea by Ursula.
In an agreement to bargain with Ursula, Triton took Ariel's place, becoming a polyp to save her. Eric hurried to save Ariel, and Ursula tried to destroy him with the Trident now in her possession, but Ariel forced away her aim. Ursula grew more powerful, but Eric defeated her and her spells were broken.
Triton came to understand Ariel, the good that can be in humankind, and her love for Eric, and he transformed Ariel back into a human, dressed in a glamorous, lilac dress. She and Eric were reunited, and they soon got married.
^Considering these things about her story can help in double checking whether there are misconceptions about her personality, desires and comfort zones that could end up misrepresenting her in your costume. Additionally, they can guide you in creating specific new designs or outfits that are themed around key moments in her life (What could her longing for the human world look like if embodied in a dress?), or perhaps an alternate version of herself (What if Triton didn't take her place and she became a polyp? What if Ursula won and started a dictatorship over Atlantica?–how would you dress like Ariel, then?).
The Little Mermaid is possibly the most difficult Disney movie to pin to one particular place and time. We know that the whole story takes place between land and sea–but beyond that, all the clues are jumbled: the fairytale it's based on was written by Danish author Hans Christian Anderson, there are elements of Greek mythology (E.g. King Triton), Sebastian has a Jamaican accent…Etcetera, etcetera. As for costume time-period clues, we've got hints of Renaissance, Edwardian (nightgown), and Georgian (Grimsby) eras, to name a few…And of course, elements inspired from the 1980s, the decade in which the Little Mermaid was created (Big, puffy sleeves…especially the wedding gown). So depending on how you look at it, there are either no ways or several ways to dress like Ariel in a "historically-accurate" costume.
Using Ariel's main color scheme is a strong indication of who you're dressing as, but using symbolism can help make it even more clear and personalized, and is especially useful if you're inspired to branch off into an especially creative, abstract version of her look.
Shells, Scales and Fins, Ocean, Sea Creatures, etc.
(Showcasing her excited curiosity over the human world).
and Scuttle, the seagull (who inspires her curiosity about the human world).
Her voice (which she used to use for singing, but gave up to Ursula for human legs).
I was so sad finding out this sweatshirt isn't available on ShopStyle or the Wildfox website anymore…But i was able to track it down and there's a few left, here, through this link (Not an affiliate link).
Purple Shells, Green Scales, Rope, Blue Bow, Pearl Drop Earrings, Pearl Hairclips/Bobby Pins. Lilac sea-flower hairpiece, navy blue cocked hat, gold crown and wedding veil (Those last three are not currently listed in my ShopStyle links).
Can you think of any other symbolic pieces?
As mentioned earlier, to dress like Ariel, using her color scheme is a strong indication.
Ariel's hair always really stands out, and it emphasizes her boldly strong-willed and playful personality, so i've included it in our discussion of her color schemes.
So, of course, her red hair is her most common color, found in all 6 outfits seen in the first movie.
Shades of green are found often and most brought to mind when we think of her colors: found on her fin and in the detailing of her wedding gown.
Purple: in her shell bra, and her formal gown from when King Triton allowed her to reunite with Prince Eric.
Pink was worn quite a bit: found in several shades in her first real human dress, and her pajamas.
Shades of sky blue, navy blue, and very light blue in the dress she wore on her day out with Eric.
Neutral colors of cream/beige/off-white in Scuttle's sail dress design and her wedding gown.
And brown and black as the occasional accent color: found in the rope on her sail dress, and in her blue "Kiss The Girl" dress.
Since we can't actually wear a real mermaid fin, it's important to consider what kinds of materials can give off the magical feeling of a mythical sea creature. Scale prints scream "mermaid" like nothing else, and they are often printed on spandex giving a smooth touch, mermaid-like a slim fit, and freedom of movement. Textured leather could be another good choice in regards to emphasizing a scale-like look and feel, but it's not as flexible so the uses would be limited. Sequins and other shimmery materials largely capture a sense of magic along with giving off a hint towards fish scales. And tulle is a typical, magical "princess fabric", which could be especially great for accenting the idea of having a fin. Additionally, silks could be a good fabric for the smooth texture, if you're desiring to dress like Ariel in something more luxuriously elegant.
Don't forget to consider the use of the outfit.
Ariel's first dress was literally just a ship's sail thrown over her and tied with rope. So, naturally, you should use a practical fabric, favorably one that would have been used for sailing: that would be either a cotton or linen. If you want to make it real simple for yourself, and super close to movie-accurate, throwing on a bedsheet and cinching it with rope or a leather belt would do well. Otherwise, a carefree-looking, preconstructed linen or cotton dress can be found, to give you the look and feel of her first dress without the impractical possibility of needing to readjust things to be sure your outfit doesn't fall apart.
Ballgowns were commonly made out of fabrics such as satin, silk, taffeta or velvet–Ariel's pink dress doesn't appear to have any sheen, though, and it holds its shape well, so i'd assume it would be best to use a thicker, matte fabric, such as velvet for the darker pink layer. I'd guess silk, cotton or flannel for the nightgown. I definitely wouldn't doubt that Ariel's wedding gown was probably silk as well.
It's good to consider the use of the outfit: When Ariel went out for a tour of the kingdom, i wouldn't doubt that dress would have been one made of a practical fabric so that it's comfortable and sensible to wear on their busy and active day around town. Cotton, or maybe linen, is a fair choice.
For Ariel's glamorous dress, the way it sparkles is the highlight–So be it glitter, jewels, sequins, or whatnot: be sure it shines.
In general, Ariel's looks are whimsical, romantic, and sweet. The shapes emphasize the delicate nature of a typical teenage girl, with elements that highlight her slender waist, either following and draping off of natural lines or contrasting them with larger shapes.
– Bodycon (Similarly contouring, but without the look of a fin at the end).
Scoop Neck. Found 4 times in her Pink Gown, Town Dress, Nightgown, and Glamorous Dress.
Sweetheart Neckline. Found 3 times in her Shell Top, Town Dress' corset, and Wedding Gown.
Strapless. Found 3 times in her Shell Top, Town Dress' corset, and Sail Dress.
Leg of Mutton Sleeve. Found 2 times in her Pink Gown, and Wedding Gown.
– Similar: Juliet, Puffed, Lantern, Bishop.
Bell-Shaped Ballgown Skirt. Found 2 times in 2 different styles: Looped/Draped Overskirt (Pink Gown), Split Overskirt (Wedding Gown).
A-line Skirt. Found 2 times in her Town Dress (tighter fitting A-line), and Nightgown (loose-fitting A-line).
– Similar: Fit and Flare, Princess Seam.
Shirt-Sleeve. Found 1 time in her Town Dress' shirt.
– Similar: Bishop, French cuff.
Poet Sleeve. Found 1 time in her Nightgown.
Sleeveless Cowl-Neck. Found 1 time in her Glamorous Dress.
– Similar: Asymmetric/One-Shoulder, Halter, Spaghetti Strap, Tank.
Asymmetrical Skirt. Found 1 time in her Glamorous Dress–The Sail Dress also has its own kind of asymmetrical hemline.
Additionally notable: ALL of Ariel's looks have long skirts.
Maxi Length. Found 4 times in her Town Dress, Sail Dress, Nightgown, and Glamorous Gown.
Floor Length. Found 2 times in her Pink Gown, and Wedding Gown–arguably, her Tail would also be floor-length.
I'm so thankful to all the wonderful bloggers, artists, and Ariel-lovers that gave me permission to use their beautiful images displayed below! Be sure to click on the images to view fullscreen, and give your favorites a visit through their social media links.
Pretty cool how many different ways there are to dress like Ariel, right?!
Ariel on Human Legs Sail Dress Costume on Reddit by Beckylee711: https://www.reddit.com/r/pics/comments/53umqd/my_ariel_on_human_legs_costume_made_a_huge_splash/ Excellent replica of the costume, along with strong symbolic pieces.
Polyvore Creation by Disney-Nerd-Designs: https://www.polyvore.com/ariel/set?id=229225665 The perfect "Kiss The Girl" cosplay.
The Little Mermaid costume on Instagram by SouthernRoseCosplay: https://www.instagram.com/p/Bbnot4snHHZ/ How on-spot is that! Wow!
Little Girls' Ariel Costume on Etsy by UCCostumes: https://www.etsy.com/listing/266411804/ariel-costume-long-sleeves-ariel How adorable is this?? I love that she used a bell-bottoms styling, allowing freedom of movement while keeping the mermaid magic by hinting at the fin. Additionally, i think it holds symbolism of when Ariel exchanged her tail for legs.
Steampunk Polyvore creation by MissSally: https://www.polyvore.com/steampunk_ariel/set?id=146244619 Could just use some more symbolic pieces.
Polyvore Creation by Amarie104: https://www.polyvore.com/ariel/set?id=200210081 Quaintly classy Ariel outfit. I like the inclusion of the rope belt. I do think it could use some more strong symbolic pieces, and a few extra touches of red to make it a little more clear that it's Ariel.
Polyvore Creation by Amarie104: https://www.polyvore.com/ariel_dapper_day/set?id=222170088 Dramatic, vintage, 1950s-style Ariel outfit, great for "Dapper Day" at Disneyland.
Ariel Sail Dress Re-Interpretation on Instagram by StoryBehindTheCloth: https://www.instagram.com/p/BWGdjQKFmgn/?taken-by=storybehindthecloth Here's my take on Ariel's first outfit after the scene where she first got her legs. I've actually had the idea in mind for quite a while, but didn't have an excuse to wear it…..so, why not today?! ? I'm clumsy enough, anyway, i may as well be walking on legs for the first time too! Let's be like Ariel and stay curious about the world around us! ?
Polyvore creation by Boho-at-Heart: https://www.polyvore.com/character_costume_ariel/set?id=230126261 I especially love the skirt choice, as it's got the perfect magical, whimsical, mermaid-like touch to it because of the fabric… And it pairs really well with the symbolic-shell-bra top, because of the contrast between casual and elegant.
Polyvore Creation by Amarie104: https://www.polyvore.com/ariel/set?id=202694224 Richly symbolic casual Ariel outfit.
Polyvore creation by MissSally: https://www.polyvore.com/boredpanda_ariel/set?id=191984714 Lots of strong symbology.
Polyvore creation by StoryBehindTheCloth: https://www.polyvore.com/trendy_ariel_2017/set?id=230853066 With Ariel's curiosity and sense adventure, i'm sure she'd be all over the latest trends all year, any year. Here's my take on her styling of some of the top trends of 2016-17: off-shoulder tops, chokers, druzy and tassel earrings, glamorized sportswear.
Polyvore Creation by Amarie104: https://www.polyvore.com/ariel/set?id=227178632 Re-Interpretation of Ariel's Sail Dress. The silhouette of the dress gives off just the right amount of a carefree "just-threw-this-on" spirit that's needed for this particular look, but with elegance!
Polyvore creation by Mikayla-Burgess: https://www.polyvore.com/prom_ariel_little_mermaid/set?id=226355845 Re-interpretation of her look into a prom dress–Closely resembles her glamorous lilac dress, with added under-sea symbolism in place by using a mermaid cut skirt.
Polyvore creation by StoryBehindTheCloth: https://www.polyvore.com/ariel_sail_dress/set?id=226330364 Re-interpretation of Ariel and her sail dress. Modeled and styled on Polyvore.
Polyvore Creation by Amarie104: https://www.polyvore.com/ariel/set?id=203300810 I love how the silhouette of the dress hints at her sail dress, but the color scheme is from her mermaid look!
Polyvore creation by HeyleeBeth: https://www.polyvore.com/ariel/set?id=188334709 Strong color scheme and symbology make this one easy to tell it's Ariel-inspired, even though the silhouette differs from her usual, allowing a casual Ariel look that you can keep warm in.
Cosplayers – SouthernRoseCosplay (Mermaid Ariel costume on Instagram). Auris (Art Nouveau Ariel, Facebook, Blog). Anastasia Phoenix (Ariel's Blue Town Dress, Instagram). Mana Hime (Sail Dress, Facebook, Instagram, Esty). Beckylee711 (Sail Dress on Reddit). Niq van der Aa aka Niq Cosplay / Detailed-Illusion (Bender-bent Ariel on Facebook, Tumblr). Holland Tayoe Gedney (Glamorous Ariel DisneyBound on Instagram, Facebook). Mashi_Thana (Shipwrecked Ariel and Eric on Instagram, Eric, Photographer, Support). Photographer Fannythz_Photo and Cosplayer + Designer LittleZanini (Ariel's Pink Dinner Dress on Instagram, Facebook). Alyssahope.Cosplay (Ariel x Harry Potter crossover on Instagram).
Etsy sellers – Debbie Kinsman (DKDesignEmporium, Sail Dress Costume – Ariel Inspired Running Costume). Svetlana Koroleva (UCCostumes, Girl's Ariel Costume). Bbeauty Designs and Dream Costume Designs (BbeautyDesigns, Ariel Resin Shells and Sequin Tail Walkable Costume). Anastasia Phoenix (PhoenixCardinal, Ariel's Blue Town Dress, Instagram).
Polyvore artists – Amarie104, MissSally, HeyleeBeth, Disney-Nerd-Designs, Mikayla-Burgess, Boho-at-Heart, A-Random-Fandom.
What are your favorite things about Ariel and her costumes?
Have you ever been able to dress like Ariel before?
Do you have any additional tips or thoughts you'd like to share? I'd love to hear from you in the comments!
What character would you like to see next?
So far, i have requests for Aurora (Sleeping Beauty), Mulan, and Sinon (Sword Art Online).


text:
The Piazza Tales
0.0 0 5 Forfatter: Herman Melville
The Piazza Tales is a collection of six short stories by American writer Herman Melville, published by Dix & Edwards in the United States in May 1856 and in Britain in June. Except for the newly written title story, "The Piazza," all of the stories had appeared in Putnam's Monthly in 1853-1855. The collection includes what has long been regarded as the author's three most important achievements in the genre of short fiction, "Bartleby, the Scrivener", "Benito Cereno", and "The Encantadas", his sketches of the Galápagos Islands.
Sprog: Engelsk Kategori: Noveller Oversætter:
South Sea Tales
Essays in the Art of Writing (Annotated)
The Man & The Sea - 10 Maritime Novels in One Edition
The Twisted Sword
The Adventure Collection: Treasure Island, The Jungle Book, Gulliver's Travels, White Fang, The Merry Adventures of Robin Hood (A to Z Classics)
50 Classic Gothic Works Vol. 1 (Golden Deer Classics)
50 Classic Christmas Stories Vol. 3 (Golden Deer Classics)
The Four Swans
The Black Moon
10 Masterpieces You Have to Read Before You Die [Halloween Edition]
The Stranger From The Sea
The Pirates' Chronicles: Greatest Sea Adventure Books & Treasure Hunt Tales (70+ Novels, Short Stories & Legends in One Edition)
50 Masterpieces you have to read before you die Vol: 1 [newly updated] (Golden Deer Classics)
50 Classic Christmas Stories Maxipack: 100+ Authors, 200 Novels, Novellas, Stories, Poems & Carols (Golden Deer Classics)
Warleggan
The Angry Tide
Pirate Latitudes

redpajama_set_name: RedPajamaCommonCrawl


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Varshney pursues all of her passions with the same fearless determination. A 2010 graduate of CMU, with a BS in Chemistry and a minor in Biomedical Engineering, Varshney was awarded a Goldwater Scholarship in 2009. While an undergraduate, she was an Andrew Carnegie Society Scholar, the university's highest undergraduate award, as well as being elected to both Phi Beta Kappa and Phi Kappa Phi.
When she applied for the Goldwater Scholarship, it was the first time Varshney thought critically about the research she was doing in the McCullough Laboratory at the Mellon Institute, and its applications, as well as what it meant for her future goals. The Goldwater Scholarship helped her crystallize her research focus, and fueled her desire to move new technologies from the lab to the market. Varshney says the Goldwater opened many doors for her. It is a scholarship that people recognize and know across the world.
After graduating from Carnegie Mellon, Varshney was awarded a Churchill Scholarship to pursue a MPhil in Micro- and Nanotechnology Enterprise at Cambridge University, a joint program between Materials Science and Business. Her passion for interdisciplinary work was nurtured while at Cambridge, as well as her skills as a researcher. Varshney worked in the Cavendish Laboratory's Optoelectronics Group, fabricating and testing organic solar cell materials. This work was a continuation of her research as an undergraduate in the McCullough Laboratory with Professor Rick McCullough, synthesizing conductive polymers for thin-film organic transistors and solar cells. That connection to McCullough proved important in instilling Varshney's interest in pure research coupled with a desire to bring new technologies to market.
Varshney returned to the United States to begin her PhD in Materials Science and Engineering at MIT, where her research in the Ortiz Structural Biomaterials Laboratory focused on developing biomimetic flexible body armor for human use inspired by fish scale biomechanics. Varshney's research is grounded in an interdisciplinary approach, as she continually seeks to integrate ideas from various fields to create something new. Varshney's doctoral work was awarded a National Science Foundation Graduate Research Fellowship.
At MIT, she restarted the Skydiving Club, and has served as President and the Gear and Sponsorships Officer for the club. Varshney says itis easy to make the connection between extreme sports and STEM, and she loves bringing science to students by focusing on the science of skydiving. Through the Skydiving Club, she reached out to do various service activities like hosting booths at the Cambridge Science Festival's Science of Sports Day and the USA Science and Engineering Festival. She worked together with her colleagues who gave talks on the Physics of Skydiving for MIT's Splash event and MIT K12 Live! at the MIT Museum. She also did the Science Out Loud video — Science Out Loud is a video series through MIT-K12 (http://www.k12videos.mit.edu/#!science-out-loud/dd886).
Varshney points to key mentors for her initial success in the Goldwater Scholarship that has helped launch her career, including Karen Stump, Teaching Professor in Chemistry at Carnegie Mellon and Rick McCullough, devoted faculty members and strong teachers. She also credits support from the Fellowships and Scholarships Office and the Undergraduate Research Office.
Varshney recently completed her Ph.D. at MIT and plans to relocate to Washington, D.C., to seek employment as a research staff scientist for a federal contactor.


text:
SUNIL GUPTA
Friends & Lovers: Coming Out in Montréal in the 1970s
Christopher Street, New York 1976
Lovers: Ten Years On
Reflections of the Black Experience
Asians / Bradford
"Pretended" Family Relationships
Trespass 1
From Here to Eternity
Tales of a City: Delhi
Imagining Childhood
Country: Portrait of an Indian Village
Mr Malhotra's Party
The New Pre-Raphaelites
Love, Undetectable
Women in Love
Helmut Lang Christopher Street
Lovers Ten Years On
Christopher Street
Delhi: Communities of Belonging
Pictures From Here
Disrupted Borders
An Economy of Signs
Ecstatic Antibodies
Fernando Arias
Divine Facades
Simryn Gill
The New Republics
Joy Gregory
Stevie Bezencenet
A Return from Exile
Relative Values
The End of Marriage
A Laying on of Hands
City of Dreams
Published by Stanley Barker, London
Published — August 2020
ISBN — 978-1-913288-09-9
Pages — 56
Cover — Swiss Bound, Soft cover, cloth spine
Size — 310 x 214mm
In 1984 SUNIL GUPTA's first long term relationship broke down in shortly after he arrived in London in 1984. He had met his lover in the early 1970's when the impact of the gay movement upon the consciousness of gay men was just gaining ground.
Then, gay was good, and gay was proud. The laws against gay sex had been turned back. The definition of homosexuality as a psychiatric disorder was successfully challenged. The commercial scene and the visibility of gay men expanded to unprecedented levels. Although, while all this change provided the individual with the means for unstigmatised sexual experimentation in relatively safe venues, simultaneously it hardly dented social attitudes and legal structures which oppressed gay relationships.
The arrival of HIV/AIDS changed all that. Gay men came under attack, from the state and its various channels. The media mounted a vicious campaign to label gay men as sick and irresponsible. Gay men were almost exclusively represented as ill. Patients of some incurable disease that had been equated with their sexuality. On the strength of this fallacy once again there was talk of reinstating repressive laws. Once again "expert medical advisors" were in on the act with their labels and talk of "containment."
Couples though had come into their own. Gay self-help groups encouraged a change in sexual behaviour and a reduction in the number of partners. However, still without legal recognition, with the new emphasis on monogamy, with social attitudes reverting to hostility and given the invisibility of day-to-day life for gay men within relationships, being a partner in the 1980s proved to be as difficult as it had been decades ago.
"These photographs were made in London. The couples define themselves as such by various criteria; some live together, some don't, some have been together a short time, some a very long time, and soon. I believe the relationship between gay men is an important but often neglected component central to their lives." - Sunil Gupta


Pizza Hut website got hacked and they didn't say anything for 2 weeks!
Pizza Hut costumers, including me are upset!! Why are we just hearing about this??
Pizza Hut emailed thousands of customers this weekend to tell them they may have been impacted by a security breach...TWO WEEKS AGO!
Over 60,000 people were affected. Thousands who placed orders online or through the brand's app between Oct. 1 and 2 , basically a 28-hour period, received a notification over the weekend. In the statement, Pizza Hut said they worked as quickly as it could to give people the heads up. Hmm...2 weeks though??
I'm not the only one that feels this way, customers went to twitter to let their voice be heard!
@pizzahut thx for the delay in your email re the breach. Do you plan on feeding my family while the bank recovers $800?
Hi, Andrew. We value our customers and take information security very seriously. Please call customer service at 1-833-210-8114.


Preliminary results from a study done on USU's campus during the spring semester of 2018 indicate that nearly 32 percent of students are food insecure.
"The purpose of the Hunger Solutions Institute is to create a group of interdisciplinary researchers, teachers, Extension faculty and agency groups to work together to research, educate and implement ideas that will help solve hunger, specifically in Utah, as well as working toward world hunger solutions," said Heidi LeBlanc, director of the USU Food $ense program.
Proposed solutions to food insecurity on college campuses include reducing the stigma associated with using food pantries, adding volunteer opportunities aimed at reducing hunger to course curriculums, and promoting events addressing root causes of food insecurity. Additionally, attendees agreed that there should be more research and more collaboration surrounding food security initiatives.
Campus groups in attendance included the Center for Community Engagement, the Division of Student Affairs, the Department of Nutrition, Dietetics, and Food Sciences, the Department of Sociology, Social Work, and Anthropology, the Department of Kinesiology and Health Sciences, the Department of Animal, Dairy, and Veterinary Sciences, and the Department of Languages, Philosophy, and Communication Studies. In addition, representatives from the University of Utah, Get Healthy Utah, and the Utah State Board of Education were key participants in the event.
For further information on the Hunger Solutions Institute and to learn about future events, contact heidi.leblanc@usu.edu to be added to the email list.


text:
Colorado Rockies Tailgating
Buy Colorado Rockies Tickets Now
Coors Field is a baseball venue located in Denver, Colorado. It is the home field of Major League Baseball's Colorado Rockies. Wikipedia
Opened: April 26, 1995
Address: 2001 Blake St, Denver, CO 80205
Sports Bars in Denver
Top Sports Bars in Denver
More Sports Bars in Denver
Top 35 Sports Bars in Denver
Colorado Rockies Forum
Colorado Rockies Website
Buy it all now on BBQSuperStars
The Colorado Rockies are a Major League Baseball (MLB) franchise based in Denver, Colorado. They are currently members of theNational League West Division. Their home venue is Coors Field. Their manager is Walt Weiss.
The Colorado Rockies have won one National League championship (2007). They mounted a spirited rally in the last month of the 2007 regular season, winning 21 of their final 22 games, and qualified for the 2007 World Series. However, they lost to the American Leaguechampion Boston Red Sox four games to none.
Main article: History of the Colorado Rockies
Denver had long been a hotbed of minor league baseball and many in the area desired a major league team. Following the Pittsburgh drug trials, an unsuccessful attempt was made to purchase the Pittsburgh Pirates and relocate them. However, in 1991, as part of Major League Baseball's two-team expansion (they also added the Florida (now Miami) Marlins), an ownership group representing Denver led by John Antonucci and Michael I. Monus were granted a franchise; they took the name "Rockies" due to Denver's proximity to the Rocky Mountains, which is reflected in their logo. They began play in 1993, sharing Mile High Stadium with the National Football League's Denver Broncos their first two seasons while Coors Field was constructed. It was completed for the 1995 Major League Baseball season.
In 1993 they started play in the western division of the National League. Since that date, the Rockies have reached the MLB postseason three times, each time as the National League wild card team. Twice (1995 and 2009) they were eliminated in the first round of the playoffs. In 2007 the Rockies advanced all the way to the World Series, only to be swept by the Boston Red Sox.
The Rockies play their home games at Coors Field. Their newest Spring Training home, Salt River Fields at Talking Stick, opened in March 2011 and is shared with the Arizona Diamondbacks.
Season record[edit]
Main article: List of Colorado Rockies seasons
Uniform[edit]
Further information: Major League Baseball uniforms
At the start of the 2012 season, the Rockies introduced "Purple Mondays" in which the team wears its purple uniform every Monday gameday.
Quick facts[edit]
Began play: 1993 (National League expansion)
Uniform colors: Black, purple, silver, and white
Logo design: Purple mountain with baseball
Team mascot: Dinger, a purple anthropomorphized triceratops
Playoff appearances (3): 1995, 2007, 2009
Owners: Linda G. Alvarado, Pete Coors, Lee Larson, Marne Obernauer, Sr., Marne Obernauer, Jr., Denver Newspaper Agency, Coors Brewing Co., Clear Channel Communications, and Beverage Distributors Corp., Dick and Charlie Monfort[1]
Chairman & CEO: Charles Monfort
Vice Chairman: Richard Monfort
President: Vacant
General Manager: Dan O'Dowd
Local Television: ROOT Sports
Spring Training Facility: Salt River Fields at Talking Stick, Scottsdale, Arizona (2011 – present)
Baseball Hall of Famers[edit]
As of the 2011 Baseball Hall of Fame election, no inducted members have played or managed for the Rockies.
Individual awards[edit]
See also: Baseball awards and List of Major League Baseball awards
NL MVP[edit]
1997 – Larry Walker
NLCS MVP[edit]
2007 – Matt Holliday
NL Rookie of the Year[edit]
1998 Todd Helton second in Rookie of the Year vote (Won by Kerry Wood)
2002 – Jason Jennings
In 2007, Troy Tulowitzki finished second in Rookie Of the Year voting.
Silver Slugger Award[edit]
Dante Bichette (1995)
Vinny Castilla (1995, 1997–98)
Andrés Galarraga (1996)
Eric Young (1996)
Ellis Burks (1996)
Larry Walker (1997, 1999)
Mike Hampton (2001–02)
Todd Helton (2000–03)
Matt Holliday (2006–08)
Carlos González (2010)
Troy Tulowitzki (2010–11)
Michael Cuddyer (2013)
Hank Aaron Award[edit]
2000 – Todd Helton
Gold Glove Award[edit]
Larry Walker (1997–99, 2001–02)
Neifi Pérez (2000)
Todd Helton (2001–02, 2004)
Carlos González (2010, 2012–13)
Nolan Arenado (2013)
Manager of the Year Award[edit]
1995 – Don Baylor
2009 – Jim Tracy
DHL Hometown Heroes (2006)[edit]
Larry Walker – voted by MLB fans as the most outstanding player in the history of the franchise, based on on-field performance, leadership quality and character value
Team award[edit]
2007 – Warren Giles Trophy (National League champion)
2007 – Baseball America Organization of the Year[2]


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text:
La Selezione Svizzera per l'Eurofestival 1992 si svolse a Lugano il 23 febbraio 1992 e presentata da Alessandra Marchese.

Canzoni in ordine di classifica

Note
Dopo la finale la canzone Soleil soleil fu squalificata in quanto era già stata presentata e scartata alle selezioni di lingua francese. Presentata alle selezioni di lingua tedesca era stata invece accettata. All'Eurovision Song Contest 1992 partecipò dunque la seconda classificata di questa selezione, Mister Music Man.

Svizzera all'Eurovision Song Contest

redpajama_set_name: RedPajamaWikipedia


text:
Broadside 2019
Tickets, packages and deals
Melbourne Town Hall
Over the weekend of Saturday 9 and Sunday 10 November 2019, Broadside takes over Melbourne Town Hall.
And, in the lower town hall, Club Skunk is the place to meet up with friends, hang out between sessions, and plan the spectacular obliteration of the patriarchy. What could be better than that? Named after the lesbian bar in 10 Things I Hate About You, it's a loving tribute to Kat Stratford and all the gloriously complex and brilliant feminists in our lives.
You'll find Melbourne Town Hall at 90–130 Swanston Street, Melbourne. A venue map is available here.
Located on one of the main thoroughfares of downtown Melbourne, public transport is one of the easiest ways to visit Melbourne Town Hall. Stops for trams #1, #3-3a, #5, #6, #11, #12, #16, #48, #64, #67, #72, #86, #96 and #109 are within a 200m walk. The nearest railway station, Flinders Street Station, is 365m away.
Several bus routes have stops in the area, including Night Bus services.
Visit PTV for the full range of stations, stops and routes near Broadside's venue, and to plan your trip.
There is some time-restricted street parking around Melbourne Town Hall, as well as various off-street car parks within a block or two, including the 199 Little Collins Street Parking, 200 Little Collins Street Garage, Scots Church, Victoria Hotel Car Park, 189 Flinders Lane and 233-239 Collins Street Parking.
There are also bicycle racks outside the building on Swanston and Collins Streets.
About Broadside
About the Wheeler Centre
Teen Day
Supporters / partners
Creative Victoria
Melbourne City of Literature
Australia Council for the Arts


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One of the architects of federal gun control legislation that was rejected says he is bringing it back.
Appearing on "Fox News Sunday," Sen. Joe Manchin said he would re-introduce a measure that would require criminal and mental health background checks for gun buyers at shows and online. The West Virginia Democrat sponsored a previous version of the measure with Republican Sen. Pat Toomey of Pennsylvania. It failed to win approval. Manchin says there was confusion over what was in the bill.
Congress took up the gun control legislation in the wake of last year's school shooting in Newtown, Conn.
Opponents included supporters of the powerful pro-gun lobby, the National Rifle Association.


Made for a country kitchen, large scale, made at Wobage Farm with Jeremy Steward. These pots took hours to fire (literally 18 hours of stoking the fire box) and I love the deep, rich warm outers and practical clear inner surfaces. These formed part of an exhibition at Tinsmiths in Ledbury.


text:
Can serial changes in diaphragm function during the spontaneous breathing trial predict the weaning outcome?
Mechanical ventilation is where a machine (ventilator) is used to assist or replace a patient's breathing. Weaning from mechanical ventilation is the process of reducing breathing support until the patient can breathe on their own. About 20% of patients have difficulties in weaning from mechanical ventilation. The outcome can be affected by a variety of factors such as heart problems, muscle weakness, and disturbances in blood electrolyte (mineral) levels. As a result, a single factor is not enough to make an accurate prediction. The diaphragm is the main muscle involved in the process of breathing. Diaphragm excursion (movement) and thickening can be measured using ultrasound scans. They have been found to reflect the functioning of the diaphragm and can be used to predict weaning outcome. They are usually measured at the start of a spontaneous breathing trial (SBT), which assesses the patient's ability to breathe while receiving minimal or no ventilator support. There have been no studies on the impact of changes in diaphragm excursion and thickening during the SBT on weaning outcomes. The aim of this study is to find out whether diaphragm function measured using ultrasound during the SBT can be used to predict the weaning outcome.
Patients aged 18 or over who are have been mechanically ventilated for more than 48 hours
When the participants are ready, they undergo an SBT for 2 hours. If the SBT fails, the participant continues with mechanical ventilation. Participants who pass the SBT are extubated (the breathing tube is removed). Diaphragm excursion and thickening are measured by ultrasound at 5 minutes, 30 minutes, 1 hour and 2 hours after the start of the SBT. Blood tests are carried out, heart function is assessed with an ultrasound scan, and the patient's ability to cough is tested.
Patients who participate in this study are examined and treated by experienced doctors. This study will not cause harm to the patient and will not have a negative impact on the patient's treatment.
Sir Run Run Shaw Hospital (China)
November 2016 to December 2017
Miss Pengmin Zhou
pmzhou@126.com
Sir Run-Run Shaw Hospital
Zhejiang University School of Medicine
+86 (0)183 571 23562
The predictive value of serial changes in diaphragm function during the spontaneous breathing trial for weaning outcome
Diaphragm function measured serially by ultrasound during the spontaneous breathing trial (SBT) is a good predictor of weaning outcome for ICU patients.
The ethics board of Sir Run Run Shaw Hospital affiliated to Zhejiang University Medical College, 31/10/2016, ref: 20161031-2
Observational cohort study
Cohort study
No participant information sheet available
The tube compensation mode (TC) is used to perform the spontaneous breathing trial (SBT) with the compensation ratio at 85%. The patients undergo SBT for 2 hours in a semi-recumbent position. If the patient fails to tolerant the SBT, the trial is terminated immediately and the patient is returned to the control mode. Patients who pass the 2-hour SBT are extubated. During the SBT, right diaphragm excursion and thickening fraction are evaluated by ultrasonography. Images are obtained at 5 minutes, 30 minutes, one hour and two hours after the initiation of SBT. Rapid shallow breathing index (RSBI) is simultaneously calculated at the bedside.
Laboratory measurements including blood gas, proBNP, chemistry profile, blood count and C reactive protein are obtained and recorded. Cardiac function is assessed by pro-BNP and echocardiography findings such as left ventricular ejection fraction (LVEF), E-point to septal separation (EPSS) and diastolic function. Attending physicians also assess the amount of endotracheal secretion and the patient's ability to cough, and they are blinded to ultrasound measurements. According to the weaning outcome, subjects are divided into two groups, the successful group and the failure group.
Diaphragm ultrasound: Patients are measured in a semi-recumbent position with the head of bed elevated between 20° and 40°. The right diaphragmatic excursion is measured with a 3.5-5MHz ultrasound probe (Mindray M9, China). The probe is placed below the right costal margin along the mid-clavicular line. The liver is used as an acoustic window. Firstly, B-mode is used to get the best approach and to select the exploration line. Then M-mode is used to display the motion of the diaphragm along the selected line. The right diaphragm thickness is measured by a 7-10MHz linear ultrasound probe set to B mode placed perpendicularly to the chest wall, in the 8th or 9th intercostal spaces, between the anterior axillary and the midaxillary lines. The diaphragm is imaged at the zone of apposition as three layer structure, including two parallel echoic lines (the diaphragmatic pleura and the peritoneal membrane) and a hypoechoic structure between them (the muscle itself) . On frozen B-mode image, the distance from the middle of the pleural line to the middle of the peritoneal line is the diaphragm thickness. Diaphragm thickening fraction (DTF) = (Thickness at end inspiration − Thickness at end expiration )/Thickness at end expiration.
Procedure/Surgery
Successful weaning, defined as spontaneous breathing (SB) for >48 hours following extubation without any level of ventilator support. A failed weaning was defined as either SBT failure or the inability to maintain SB for at least 48 hours after extubation.
1. All patients in the ICU who are mechanically ventilated for more than 48 hours through an endotracheal tube
2. Absence of fever
3. Alert and cooperative
4. Hemodynamically stabile without vasopressors
5. Improved respiratory function with FiO2 < 0.5, PEEP ≤5 cmH2O, PaO2/FiO2 > 200 and respiratory rate <30 breaths per minute
6. Aged 18 or over
1. History of diaphragm paralysis
2. Cervical spine injury
3. Neuromuscular diseases
4. A current thoracostomy
5. Pneumothorax
6. Pneumomediastinum
Sir Run Run Shaw Hospital
Qingchun Road No. 3
It is the trialist's intention to publish the protocol in November 2016 and the results in December 2017.
IPD sharing plan
The datasets generated and/or analysed during the current study are available from Pengmin Zhou
(pmzhou@126.com) on reasonable request.
2017 protocol in https://pubmed.ncbi.nlm.nih.gov/28645964/ (added 27/11/2020)
27/11/2020: Publication reference added.


Good weather prevailed on Sat. & Sunday with temps in the mid to upper 80s. Sunday, with lower humidity, was cloudless so lift wasn't as good as Sat. – but it was still there!
We're left to blaming the Monday eclipse for keeping VSA members away. Thanks to Kristin Farry of Madison, VA for bringing her Schweizer SGS 1-26A & Gerry Wild of Lansdale, PA for bringing his Hütter 17. Bob Dierker of Chestertown, MD gave about a dozen rides to visitors in his Schweizer 2-33 while Rusty Lowry provided the tows in Massey's Cessna 182. Kristen Farry got a good ride on Sat. (+1.5 hours) but headed south to view the eclipse on Sunday (I hope it wasn't cloudy wherever she went).
Gerry Wild prefers a slower tail wheel tow plane so we used the Bailey-Moyes Dragonfly on Sunday. Since the Hütter has only a skid (no wheel) it took a little rocking to break it loose initially but once it started to move it worked perfectly. Kristen Wild had poured a bucket of soapy water on the grass in front of the Hütter, the rope grew taut and the Dragonfly strained until the Hütter finally broke free, helped by the wing walker's gentle persuasion. The Bailey-Moyes Dragonfly was designed and built solely as a hang glider tug but knowing that it was capable of towing the 400 lb. Bailey-Moyes Tempest glider (which does have a wheel), John suggested we give it a try and voilà it worked.
Gp. Capt. "Willy" Hackett, RAF, was back, he is stationed at Paxtuxent River for the F-35 Lightning II Joint Program Office. We were glad to help him add new types to his log book. Rusty made the last flight of the weekend in his 1-23 after spending most of his time towing with the C182.
We're open to suggestions to attract more participants – This year we provided good weather, good facilities, good equipment and friendly, interesting people. You know Massey has a great grass runway with open approaches surrounded mostly by farmland in case you're caught out. Let's not lose this event!
Massey's Schweizer SGU 2-22 on tow.
Massey's Cessna 182 tows our Schweizer SGU 2-22 on Sat.
Assembling Gerry Wild's Hütter 17.
Gerry Wild's Hütter 17 on tow behind the Bailey-Moyes Dragonfly.
Bob Dierker orients Gp. Capt. "Willy" Hackett RAF, in Rusty's Schweizer 1-23.
Rusty's Schweizer 1-23 on tow behind Massey's C182.
Bob Dierker conducting one of the many glider rides at the VSA meet.
Rusty pilots Massey's C182 tow plane and Bob Dierker his 2-33 two place glider.


text:
Thousands of striking Matamoros, Mexico workers march to border to appeal to US workers
By Alex González
The strike by 70,000 "maquiladora" workers in Matamoros, Mexico has entered its second week and continues to intensify each day. Yesterday, workers held a protest titled "A Day Without Workers" to demonstrate that it is the working class—not the unions or the bosses—that generates all of society's wealth.
Photos circulating on social media showed deserted factories and union bureaucrats struggling to keep production lines operating after workers put down their tools en masse. Over 50 factories have now stopped production as a result of the strike, costing corporations an estimated $100 million over the course of one week.
After refusing to show up to work, the auto parts and electrical workers held a massive march through the city of 500,000, chanting "we will win this fight no matter what," "the workers united will never be defeated," and "empty plants, a day without workers!"
The strike in Matamoros, like any significant movement of the masses, is characterized by the striving for social equality. The demands of the Matamoros workers—a 20 percent wage increase, a USD$1,700 bonus, a shorter work week, and cuts to union dues—are class issues that unite all workers regardless of race, gender, sexual orientation or national origin.
In the course of their struggle, the workers are instinctively seeking to form links across irrational nation-state boundaries. The rally was originally scheduled to take place in the town square, but was redirected in the course of the march when workers decided to march to the border crossing between Matamoros, Mexico and Brownsville, Texas so they could appeal to US workers as their class allies. As they were marching near the border, many demonstrators called on their US counterparts to join their struggle, chanting "gringos [Americans], wake up!"
Oscar, a maquiladora worker in Matamoros, told the WSWS that workers chose to march to the border "to be heard, because the government in Matamoros doesn't care. At the bridge we have our sights set on Brownsville, Texas. This way I hope they can see us."
A former Canadian GM autoworker told the WSWS Autoworker Newsletter: "Thank you brothers and sisters in Mexico for taking a stand for all North American workers. Unity amongst those of us who do the work is key to taking back fair wages and pursuing safer workplaces that strive for continuous improvement. The only way to fight back is to stop allowing them to put us up against each other and stand together against the corrupt unions and corporations that take and take and take from us."
The events in Matamoros are the progressive answer to the nationalism and anti-immigrant chauvinism of Donald Trump and the US and Canadian trade unions. By erecting walls and fences, the ruling elites all around the world have artificially divided workers that are exploited by the same companies in different portions of the production process.
Under a globally integrated economy, workers have the power to disrupt the supply chain and threaten to shut down entire industries. The WSWS has received reports that sections of the North American auto industry have been stalled due to a shortage of auto parts produced in Matamoros. This occurs at the same time as 15,000 US and Canadian autoworkers from General Motors (GM) are fighting against planned plant closures, wage cuts, and other concessions that will funnel ever more profits into the portfolios of the rich.
The logic of the Matamoros strike will pit the workers ever more openly against the entire political and economic system. The unions and state apparatus are consciously working to sap the independent initiative of the workers so it can be strangled and betrayed.
Yesterday, Matamoros Mayor Mario López of the Movement for National Regeneration (Morena) addressed the demonstration at the city plaza for the first time since the strike began. He wholeheartedly defended the "right" of corporations to extract massive profit out of the workers and refused to state his support for the strike. He said: "I want to tell you that since this began, no one has been more concerned about labor stability but me. Matamoros needs peace and quiet. I have a responsibility to rule Matamoros. I sent some people to Mexico City, the corporate class is also worried … Here I will not intervene because it is a fight between the workers and the companies."
At a press conference after the rally, a reporter asked him whether or not he thought the workers' demands were fair. He said: "We have to find balance. The thing is that if there is no agreement, the companies can leave, it has happened before. I am urging them not to leave. A corporation can say, 'I can't give them that.'"
When angry workers at the plaza responded by shouting, "we want justice" and "you are not supporting us," Javier Zuniga Garcia from the Tamaulipas Miners Union, a supposed more "radical" union leader, took over the microphone to help bolster the mayor. "We are doing this to avoid a social problem that can develop here in Matamoros," he said. "Let's give our mayor our trust …we give him credit for being here. We want to keep trusting in our institutions. If [union leaders] Villafuerte or Mendoza come they will have the same rights as the mayor."
Workers should reject the lie by the politicians, the unions and the companies that "there is no money" to pay their wage increases or their bonuses. The maquiladora industry controls two-thirds of Mexico's exports and generates billions in profits from imposing sweatshop conditions on more than a million people. These threats to shut down plants are attempts to bully the Matamoros workers into submission and make an example of them to keep the strike from spreading elsewhere. The corporate losses caused by the strike could have already paid the bonuses demanded by the workers multiple times over.
There has not been a single article on the Matamoros strike in the international press—the largest strike in North America in two decades—precisely because the ruling elite is afraid that other workers will follow the example that the Matamoros workers are setting by rebelling against their trade unions and seeking the support of workers internationally. This media blackout must be overcome by the workers themselves using social media to reach their class brothers and sisters around the world, who are watching their unfolding struggle with great interest and enthusiasm.
Appeals to Mexican president Andrés Manuel López Obrador (AMLO), the federal mediation process proposed by the mayor, or a "reform" of the unions proposed by labor lawyer Susana Prieto Terrazas are all recipes for disaster.
Workers must understand that they are up against the capitalist system and that all politicians and unions—from the mayor all the way up to the president and the courts—defend the "right" of the corporations to exploit the working class.
The working class needs its own organizations of struggle that will be able to draw on the social strength of the international working class. Workers must follow the model set in some plants in Matamoros by electing rank-and-file delegates and building a new, democratic city-wide strike committee to direct the struggle and prevent the unions from strangling their cause with empty promises.
We urge workers to contact us by email at autoworkers@wsws.org or our Facebook page in order to take up these crucial steps.
The 2019 Matamoros workers strike
Thousands walk out in Matamoros as Mexican government lets corporations continue production during pandemic
Mexican National Guard deployed against Matamoros auto parts workers
Workers Struggles: The Americas
GM workers in Mexico thank US workers for donating to their defense fund
AFL-CIO, Mexican government seek to chain renewed struggles across Matamoros to "independent" trade unions
Autoworkers
Wage theft exposed at Fiat Chrysler/Stellantis Detroit Assembly Complex
What workers need to know about the Fiat Chrysler-PSA merger
CAMI autoworkers should reject Unifor's attempt to reopen contract with GM Canada!
Ford shuts down operations in Brazil, destroying tens of thousands of jobs
Two GM Silao workers in Mexico die on Christmas Eve
AMLO government falsified COVID-19 data to avoid shutdowns in Mexico City
Death toll rises to 11 at General Motors plant in Silao, Mexico
15-year-old is assassinated while being treated in hospital in Mexico as homicides reach record levels


Klei's popular space science, management and survival sandbox Oxygen Not Included will launch out of early access late this May, almost exactly two years from its original debut. In a recent announcement on their official forums, Klei stated that the game was in the final stretch now, and there's only one update planned between now and launch. The final version of the game, while not having a specific date yet, will launch with three new biomes, new creatures, buildings and more, plus official mod support allowing players to take up the development gauntlet.
Launching out of early access doesn't mean the end of Oxygen Not Included, of course. This is Klei, after all – they're still expanding the much older Don't Starve and its multiplayer spinoff, after all. The studio say once the game is finished, the bulk of the development team will be moving on to DLC. Between now and launch day, they're working on one final round of quality-of-life improvements for the game, capping off the previous two similarly-themed updates. Personally, I'm looking forward to the animated short accompanying the final release. They're always cute, and gradually tell an unfolding story.
Oxygen Not Included remains hugely popular, with thousands of players tinkering with their space-colonies at any given moment – Klei themselves are still surprised, given how niche they initially thought the concept. Brendan took a look at it just before its early access debut, and thought it was on the right track. It's grown a startling amount since then, with thermal management systems, germ simulation and medical science, agricultural systems to keep your little space-folks fed and more. Recent updates have let players pump and refine oil, produce advanced automated systems with logic gates, and expand their colony ambitions far and wide.
It would be foolish to try and list all the hundreds of things they've added to the game – many of them big, fundamental upgrades – since launch, but you can see all their update notes on Steam here. Still, the game remains cartoony, accessible and friendly at a fundamental level. There's a lot involved in managing a space station and the lives of the little idiot people within, but I feel that Klei have made it easy to get into in a way that Dwarf Fortress and Rimworld (much as I enjoy them) haven't. I'm looking forward to Version 1.0, and whatever they've got planned as DLC.
Oxygen Not Included leaves early access in "late May". If you can't wait, you can snag it here on Steam or Epic for £19/23/$25. If you have several of Klei's other sandbox games, you may find it cheaper here in their Survival Bundle, which includes Oxygen Not Included, Don't Starve, Don't Starve Together and all their expansions. You can (and should) watch all the update animated shorts here.


text:
El Honda CR-V es un Vehículo Crossover del segmento C producido por el fabricante japonés de automóviles Honda.

Historia
El CR-V, cuyas iniciales significan "Crossover Recreative Vehicle" (Vehículo Crossover Recreativo, abarca hasta el momento seis generaciones, lanzadas respectivamente en los años 1996, 2002, 2007, 2012, 2017 y 2023, las cuales siempre han compartido elementos estructurales y de equipamiento con el modelo Honda Civic, al ser CR-V su versión Crossover.

CR-V es un crossover cinco puertas de cinco plazas disponible con tracción delantera ó tracción a las cuatro ruedas. Tiene como rivales al Citroën C5 Aircross, Ford Escape, Kia Sportage, Hyundai Tucson, Mazda CX-5, Opel Grandland X, Peugeot 3008, Renault Koleos, Toyota RAV4, Volkswagen Tiguan entre otros.

Se ha destacado como un vehículo muy confiable, de gran calidad, muy cómodo y polivalente. Posee notables prestaciones y es equilibrado en su consumo de combustible.

La primera saga tenía un motor de gasolina de 2.0 con 130 HP. La transmisión podía ser mecánica de cinco velocidades o automática de cuatro, esta última con la palanca en la columna de dirección, lo que deja gran espacio en la cabina delantera. Se comercializaba exclusivamente con tracción a las cuatro ruedas. Este sistema fue considerado un gran avance en la época porque era capaz de conectar de forma automática el eje trasero en caso de que el delantero perdiera adherencia. Este sistema era llamado "Real Time 4WD" y su activación no requiere intervención alguna de parte del conductor. Su funcionamiento es simple y confiable, sin embargo no posee una muy buena capacidad de tracción debido al lento acople del eje trasero, en especial en terrenos deslizantes, lo que podía llegar a comprometer la estabilidad de marcha en ciertas situaciones. Con las futuras generaciones se introdujeron mejoras en el sistema que lo fueron haciendo más confiable y seguro en su accionar.

En sus primeros 11 años de vida (hasta la tercera generación) se han vendido casi 2,5 millones de unidades.

Referencias

Enlaces externos

 Datos y precios al día del Honda CR-V

CR-V
Modelos de automóviles todoterreno
Modelos de automóviles del segmento C
Vehículos utilitarios deportivos compactos


text:
The IMPACT Mentoring Program: Exploring the Benefits of Mentoring for Emeriti Faculty
Faculty Development Medley
Diversity and Faculty Development Constituency Committee
https://peer.asee.org/31104
Sylvia L. Mendez University of Colorado, Colorado Springs
Dr. Sylvia Mendez is an Associate Professor and Chair of the Department of Leadership, Research, and Foundations at the University of Colorado Colorado Springs. She earned a PhD in Educational Leadership and Policy Studies from the University of Kansas, a MS in Student Affairs in Higher Education from Colorado State University, and a BA in Economics from Washington State University. Dr. Mendez's research centers on the educational attainment and schooling experiences of Mexican descent youth in the mid-20th century, higher education student success, and faculty mentoring programs.
Valerie Martin Conley University of Colorado, Colorado Springs
Valerie Martin Conley is dean of the College of Education and professor of Leadership, Research, and Foundations at the University of Colorado Colorado Springs. She previously served as director of the Center for Higher Education, professor, and department chair at Ohio University. She was the PI for the NSF funded research project: Academic Career Success in Science and Engineering-Related Fields for Female Faculty at Public Two-Year Institutions. She is co-author of The Faculty Factor: Reassessing the American Academy in a Turbulent Era.
Comas Lamar Haynes Georgia Tech Research Institute
Comas Lamar Haynes is a Principal Research Engineer / faculty member of the Georgia Tech Research Institute and Joint Faculty Appointee at the Oak Ridge National Laboratory. His research includes modeling steady state and transient behavior of advanced energy systems, inclusive of their thermal management, and the characterization and optimization of novel cycles. He has advised graduate and undergraduate research assistants and has received multi-agency funding for energy systems analysis and development. Sponsor examples include the National Science Foundation, Department of Energy and NASA. Dr. Haynes also develops fuel cells and alternative energy systems curricula for public and college courses and experimental laboratories. Additionally, he is the co-developer of the outreach initiative, Educators Leading Energy Conservation and Training Researchers of Diverse Ethnicities (ELECTRoDE). He received his Bachelor of Science degree from Florida A&M University and his graduate degrees (culminating in a Ph.D.) from Georgia Tech; and all of the degrees are in the discipline of Mechanical Engineering.
Rosario A. Gerhardt Georgia Institute of Technology
Dr. Rosario A. Gerhardt is Professor of Materials Science and Engineering at the Georgia Institute of Technology. In addition to her engineering research interests, she is also interested in improving diversity at the K-12, undergraduate, graduate and faculty level. She has been primary organizer as well as a faculty mentor for several Future Faculty Workshops. She also worked in the Office of Institute Diversity at Georgia Tech on a part-time basis from 2011-2015. She was named Senior Goizueta Faculty Chair in 2015.
Jennifer Tygret University of Colorado, Colorado Springs
This evidence-based holistic single-case study reports on the benefits mentors accrued from participating in the Increasing Minority Presence within Academia through Continuous Training (IMPACT) mentoring program. The IMPACT program was sponsored by the National Science Foundation (15-7680) Office for Broadening Participation in Engineering. In this program, emeriti faculty were matched with underrepresented minority faculty in the engineering professoriate for career-focused mentorship. The conceptual framework of the Benefits of Being a Mentor (Ragins & Scandura, 1999) grounded this study. Findings indicate mentors appreciated the opportunity to give back and remain engaged in the field, to relive past academic career experiences, and to support the next generation of engineering professors while adjusting to retirement. These findings aligned with the conceptual framework on three factors: rewarding experience, improved job performance, and generativity. Implications for administrators and faculty, as well as additional research areas, are discussed.
Mendez, S. L., & Conley, V. M., & Haynes, C. L., & Gerhardt, R. A., & Tygret, J. (2018, June), The IMPACT Mentoring Program: Exploring the Benefits of Mentoring for Emeriti Faculty Paper presented at 2018 ASEE Annual Conference & Exposition , Salt Lake City, Utah. 10.18260/1-2--31104
Mendez, S. L., & Conley, V. M., & Haynes, C. L., & Gerhardt, R. A., & Tygret, J. (2018, June), The IMPACT Mentoring Program: Exploring the Benefits of Mentoring for Emeriti Faculty  Paper presented at 2018 ASEE Annual Conference & Exposition , Salt Lake City, Utah. 10.18260/1-2--31104
Mendez, S. L., \& Conley, V. M., \& Haynes, C. L., \& Gerhardt, R. A., \& Tygret, J. (2018, June), \emph{The IMPACT Mentoring Program: Exploring the Benefits of Mentoring for Emeriti Faculty}
Paper presented at 2018 ASEE Annual Conference \& Exposition , Salt Lake City, Utah.
Sylvia L. Mendez, Valerie Martin Conley, Comas Lamar Haynes, Rosario A. Gerhardt, and Jennifer Tygret.  "The IMPACT Mentoring Program: Exploring the Benefits of Mentoring for Emeriti Faculty".  2018 ASEE Annual Conference & Exposition , Salt Lake City, Utah, 2018, June.  ASEE Conferences, 2018.  https://peer.asee.org/31104 Internet.  19 Jan, 2022
Sylvia L. Mendez, Valerie Martin Conley, Comas Lamar Haynes, Rosario A. Gerhardt, and Jennifer Tygret.
"The IMPACT Mentoring Program: Exploring the Benefits of Mentoring for Emeriti Faculty".
\emph{2018 ASEE Annual Conference \& Exposition , Salt Lake City, Utah, 2018, June}.
https://peer.asee.org/31104 Internet.  19 Jan, 2022
author = "Sylvia L. Mendez, Valerie Martin Conley, Comas Lamar Haynes, Rosario A. Gerhardt, and Jennifer Tygret"
title = "The IMPACT Mentoring Program: Exploring the Benefits of Mentoring for Emeriti Faculty"
booktitle = "2018 ASEE Annual Conference \& Exposition "
address = "Salt Lake City, Utah"
note = {https://peer.asee.org/31104}
AB  - This evidence-based holistic single-case study reports on the benefits mentors accrued from participating in the Increasing Minority Presence within Academia through Continuous Training (IMPACT) mentoring program. The IMPACT program was sponsored by the National Science Foundation (15-7680) Office for Broadening Participation in Engineering. In this program, emeriti faculty were matched with underrepresented minority faculty in the engineering professoriate for career-focused mentorship. The conceptual framework of the Benefits of Being a Mentor (Ragins & Scandura, 1999) grounded this study. Findings indicate mentors appreciated the opportunity to give back and remain engaged in the field, to relive past academic career experiences, and to support the next generation of engineering professors while adjusting to retirement. These findings aligned with the conceptual framework on three factors: rewarding experience, improved job performance, and generativity. Implications for administrators and faculty, as well as additional research areas, are discussed.
AU  - Sylvia L. Mendez
AU  - Valerie Martin Conley
AU  - Comas Lamar Haynes
AU  - Rosario A. Gerhardt
AU  - Jennifer Tygret
CY  - Salt Lake City, Utah
TI  - The IMPACT Mentoring Program: Exploring the Benefits of Mentoring for Emeriti Faculty
UR  - https://peer.asee.org/31104


text:
Debiopharm International SA. (10/20/16). "Press Release: Debiopharm International SA Announces Clinical Collaboration with the Merck-Pfizer Alliance in Cancer Immunotherapy". Lausanne.
Organisation Debiopharm International S.A.
Group Debiopharm (Group)
Organisation 2 Merck KGaA
Group Merck (DE) (Group)
Product clinical research
Product 2 avelumab (MSB0010718C)
Index term Pfizer–Merck (DE): antibody cancer drug, 201411– collab dev + commerc of anti-PD-L1 antibody $850m upfront + $2b milestones + shared costs + revenues
Person Freitag, Chris (Dynacure 201807– CMO before Debioparm + BTG plc + Shire + Roche)
Person 2 Reicin, Alise (Merck (DE) 201505– Head Global Clinical Development before MSD)
This joint effort will initially focus on a Phase I/Ib trial in patients with Lung Cancer to assess safety and preliminary efficacy of Debio 1143 in combination with avelumab
Debiopharm International (Debiopharm – www.debiopharm.com) today announced that it has entered into a collaboration agreement with Merck and Pfizer (NYSE:PFE) to evaluate Debio 1143, an oral, small molecule inhibitor of IAPs (Inhibitor of Apoptosis Proteins), in combination with avelumab, an investigational fully human anti-PD-L1 IgG1 monoclonal antibody, in patients with advanced or metastatic Non-Small Cell Lung Cancer (NSCLC). Debio 1143 is currently in Phase II development for Head & Neck and Ovarian Cancer. Avelumab is under clinical investigation across a broad range of tumor types by the Merck-Pfizer Alliance. Under the terms of the agreement, Debiopharm will be responsible for conducting the Phase I/Ib clinical trial in NSCLC.
"We are delighted to initiate this collaboration in immuno-oncology with the Merck-Pfizer Alliance. It is a great opportunity to explore in the clinic the immunomodulatory properties of Debio 1143 observed in preclinical studies," said Dr Chris Freitag, Vice President, Clinical Research & Development, Debiopharm International SA. "We are hopeful that the immunosensitizing effect of our compound in combination with avelumab may translate into a potentially better treatment outcome for patients suffering from this major debilitating disease."
Globally, lung cancer is the leading cause of cancer death among both men and women, responsible for more deaths than colon, breast and prostate cancer combined.1 NSCLC is the most common type of lung cancer, accounting for 80-85% of all lung cancers.2 The 5-year survival rate for people diagnosed with late-stage lung cancer that has spread (metastasized) to other areas of the body is 4%.3
"Inhibition of the PD-1/PD-L1 pathway has shown promising activity in patients with advanced NSCLC," said Alise Reicin, M.D., Head of Global Clinical Development in the biopharma business of Merck. "We hope that our exploration of avelumab as a combination therapy with Debio 1143 will generate results that could potentially one day make a real difference to patients fighting this deadly cancer."
"Investigating the potential of combination therapy is an important strategic focus for the Merck-Pfizer Alliance," said Chris Boshoff, M.D., Ph.D., Head of Immuno-Oncology, Early Development, and Translational Oncology at Pfizer. "This collaboration with Debiopharm provides a significant opportunity to explore the potential synergistic effects of these two agents in combination."
About Debio 1143
Debio 1143 is an oral, small molecule inhibitor of IAPs (Inhibitor of Apoptosis Proteins) that promotes apoptosis of cancer cells by mimicking the activity of the natural Second Mitochondrial-derived Activator of Caspases (SMAC). Evasion of apoptosis is a hallmark of cancer and a common mechanism of resistance to current treatments and Debio 1143 is being investigated as chemo- and radio-sensitizer in Ovarian Cancer and Head & Neck Cancer. In addition, like other members of the class, Debio 1143 displays strong immunomodulatory properties that make it a natural candidate for combination with Immune Checkpoint Inhibitors.
About Avelumab
Avelumab (also known as MSB0010718C) is an investigational, fully human antibody specific for a protein found on tumor cells called PD-L1, or programmed death ligand-1. Avelumab is thought to have a dual mechanism of action which may enable the immune system to find and attack cancer cells. By binding to PD-L1, avelumab is thought to prevent tumor cells from using PD-L1 for protection against white blood cells such as T-cells, exposing them to anti-tumor responses. Avelumab is also thought to help white blood cells such as natural killer (NK) cells find and attack tumors in a process known as ADCC, or antibody-dependent cell-mediated cytotoxicity. In November 2014, Merck, the science and technology company, and Pfizer announced a strategic alliance to co-develop and co-commercialize avelumab.
About Debiopharm International SA
Debiopharm Group™ is a Swiss-based global biopharmaceutical group of five companies active in the development and manufacture of drugs and diagnostics tools. Debiopharm focuses on developing prescription drugs that target unmet medical needs. The group in-licenses and develops promising drug candidates. The products are commercialized by pharmaceutical out-licensing partners to give access to the largest number of patients worldwide.
For more information, please see www.debiopharm.com
We are on Twitter. Follow @DebiopharmNews at http://twitter.com/DebiopharmNews
1. American Cancer Society (2016) Key Statistics for Lung Cancer. Available from: http://www.cancer.org/cancer/lungcancer-non-smallcell/detailedguide/non-small-cell-lung-cancer-key-statistics. Accessed August 2016.
2. American Cancer Society (2016) What is Non-Small Cell Lung Cancer? Available from: http://www.cancer.org/cancer/lungcancer-non-smallcell/detailedguide/non-small-cell-lung-cancer-what-is-non-small-cell-lung-cancer. Accessed August 2016.
3. Mayo Clinic (2016) Cancer survival rate: what it means for your prognosis. Available from: http://www.mayoclinic.org/diseases-conditions/cancer/in-depth/cancer/art-20044517. Accessed August 2016.
Debiopharm International SA Contact
Christelle Tur
Communication Coordinator
christelle.tur@debiopharm.com
More documents for Debiopharm (Group)
[1] Debiopharm International SA. (6/12/19). "Press Release: Debiopharm and Ipsen Extend Their Strategic Decapeptyl (triptorelin) Partnership for another 15 Years". Lausanne & Paris....
[2] Debiopharm International SA. (5/14/19). "Press Release: Debiopharm Awarded $2.1 Million from CARB-X in the Fight against a Highly Resistant Nosocomial-pneumonia Causing Superbug". Lausanne....
[3] Dynacure S.A.S.. (7/10/18). "Press Release: Dynacure Names Chris Freitag (MD) Chief Medical Officer". Strasbourg....
[4] Debiopharm International SA. (6/20/17). "Press Release: Almac Discovery and Debiopharm International SA Announce a Licensing Agreement for the Development of a Novel Wee-1 Inhibitor". Craigavon & Lausanne....
[5] Debiopharm International SA. (5/24/17). "Press Release: Debiopharm International SA Enters the Field of Antibody-Drug Conjugates through Acquisition of Phase II Asset from ImmunoGen". Lausanne....
[6] BC Platforms. (5/9/17). "Press Release: BC Platforms Closes USD $10 Million Series B Financing Led by Debiopharm and Tesi to Accelerate Knowledge Platform Development"....
[7] Debiopharm International SA. (10/25/16). "Press Release: Debiopharm International SA Reaches Important Development Milestones for its Staphylococcus-selective Antibiotic Debio 1450". Lausanne....
[8] Debiopharm S.A.. (8/30/16). "Press Release: Debiopharm Invests Double Digit Millions in the Canadian Startup GenePOC, Specialized in the Development of Rapid Diagnostic Tests". Québec & Lausanne....
[9] Debiopharm S.A.. (7/13/16). "Press Release: Debiopharm Acquires a Majority Holding in the Canadian Start-up GenePOC". Lausanne....
[10] Debiopharm International SA. (9/8/15). "Press Release: Debiopharm International SA and Solid Biosciences, LLC, Announce a Collaboration to Explore the Use of Alisporivir (Debio 025) in Muscular Dystrophy". Lausanne & Cambridge, MA....