text:
Measurable residual disease does not preclude prolonged progression-free survival in CLL treated with ibrutinib
Xin Victoria Wang, Curtis A. Hanson, Renee C. Tschumper, Connie E. Lesnick, Esteban Braggio, Elisabeth M. Paietta, Susan O'Brien, Jacqueline C. Barrientos, Jose Francisco Leis, Cong Christine Zhang, Steven E. Coutre, Paul M. Barr, Amanda F. Cashen, Anthony R. Mato, Avina K. Singh, Michael P. Mullane, Harry Erba, Richard Stone, Mark R. Litzow, Martin S. Tallman
Tait D. Shanafelt, Neil E. Kay
E1912 was a randomized phase 3 trial comparing indefinite ibrutinib plus 6 cycles of rituximab (IR) to 6 cycles of fludarabine, cyclophosphamide, and rituximab (FCR) in untreated younger patients with CLL. We describe measurable residual disease (MRD) levels in E1912 over time and correlate them with clinical outcome. Undetectable MRD rates (<1 CLL cell per 104 leukocytes) were 29.1%, 30.3%, 23.4%, and 8.6% at 3, 12, 24, and 36 months for FCR, and significantly lower at 7.9%, 4.2%, and 3.7% at 12, 24, and 36 months for IR, respectively. Undetectable MRD at 3, 12, 24, and 36 months was associated with longer progression-free survival (PFS) in the FCR arm, with hazard ratios (MRD detectable/MRD undetectable) of 4.29 (95% confidence interval [CI], 1.89-9.71), 3.91 (95% CI, 1.39-11.03), 14.12 (95% CI, 1.78-111.73), and not estimable (no events among those with undetectable MRD), respectively. In the IR arm, patients with detectable MRD did not have significantly worse PFS compared with those in whom MRD was undetectable; however, PFS was longer in those with MRD levels <10−1 than in those with MRD levels above this threshold. Our observations provide additional support for the use of MRD as a surrogate end point for PFS in patients receiving FCR. In patients on indefinite ibrutinib-based therapy, PFS did not differ significantly by undetectable MRD status, whereas those with MRD <10−1 tended to have longer PFS, although continuation of ibrutinib would very likely be necessary to maintain treatment efficacy.
https://doi.org/10.1182/blood.2020010146
Published - Dec 30 2021
10.1182/blood.2020010146
Dive into the research topics of 'Measurable residual disease does not preclude prolonged progression-free survival in CLL treated with ibrutinib'. Together they form a unique fingerprint.
Ibrutinib Chemical Compounds 100%
PCI 32765 Medicine & Life Sciences 83%
Cyclophosphamide Chemical Compounds 78%
Progression-Free Survival Medicine & Life Sciences 50%
Rituximab Medicine & Life Sciences 23%
fludarabine Medicine & Life Sciences 22%
Time Chemical Compounds 5%
Wang, X. V., Hanson, C. A., Tschumper, R. C., Lesnick, C. E., Braggio, E., Paietta, E. M., O'Brien, S., Barrientos, J. C., Leis, J. F., Zhang, C. C., Coutre, S. E., Barr, P. M., Cashen, A. F., Mato, A. R., Singh, A. K., Mullane, M. P., Erba, H., Stone, R., Litzow, M. R., ... Kay, N. E. (2021). Measurable residual disease does not preclude prolonged progression-free survival in CLL treated with ibrutinib. Blood, 138(26), 2810-2827. https://doi.org/10.1182/blood.2020010146
Measurable residual disease does not preclude prolonged progression-free survival in CLL treated with ibrutinib. / Wang, Xin Victoria; Hanson, Curtis A.; Tschumper, Renee C.; Lesnick, Connie E.; Braggio, Esteban; Paietta, Elisabeth M.; O'Brien, Susan; Barrientos, Jacqueline C.; Leis, Jose Francisco; Zhang, Cong Christine; Coutre, Steven E.; Barr, Paul M.; Cashen, Amanda F.; Mato, Anthony R.; Singh, Avina K.; Mullane, Michael P.; Erba, Harry; Stone, Richard; Litzow, Mark R.; Tallman, Martin S.; Shanafelt, Tait D.; Kay, Neil E.
In: Blood, Vol. 138, No. 26, 30.12.2021, p. 2810-2827.
Wang, XV, Hanson, CA, Tschumper, RC, Lesnick, CE, Braggio, E, Paietta, EM, O'Brien, S, Barrientos, JC, Leis, JF, Zhang, CC, Coutre, SE, Barr, PM, Cashen, AF, Mato, AR, Singh, AK, Mullane, MP, Erba, H, Stone, R, Litzow, MR, Tallman, MS, Shanafelt, TD & Kay, NE 2021, 'Measurable residual disease does not preclude prolonged progression-free survival in CLL treated with ibrutinib', Blood, vol. 138, no. 26, pp. 2810-2827. https://doi.org/10.1182/blood.2020010146
Wang XV, Hanson CA, Tschumper RC, Lesnick CE, Braggio E, Paietta EM et al. Measurable residual disease does not preclude prolonged progression-free survival in CLL treated with ibrutinib. Blood. 2021 Dec 30;138(26):2810-2827. https://doi.org/10.1182/blood.2020010146
Wang, Xin Victoria ; Hanson, Curtis A. ; Tschumper, Renee C. ; Lesnick, Connie E. ; Braggio, Esteban ; Paietta, Elisabeth M. ; O'Brien, Susan ; Barrientos, Jacqueline C. ; Leis, Jose Francisco ; Zhang, Cong Christine ; Coutre, Steven E. ; Barr, Paul M. ; Cashen, Amanda F. ; Mato, Anthony R. ; Singh, Avina K. ; Mullane, Michael P. ; Erba, Harry ; Stone, Richard ; Litzow, Mark R. ; Tallman, Martin S. ; Shanafelt, Tait D. ; Kay, Neil E. / Measurable residual disease does not preclude prolonged progression-free survival in CLL treated with ibrutinib. In: Blood. 2021 ; Vol. 138, No. 26. pp. 2810-2827.
@article{e42fd75afdcd4d6689c69aecd23dab0a,
title = "Measurable residual disease does not preclude prolonged progression-free survival in CLL treated with ibrutinib",
abstract = "E1912 was a randomized phase 3 trial comparing indefinite ibrutinib plus 6 cycles of rituximab (IR) to 6 cycles of fludarabine, cyclophosphamide, and rituximab (FCR) in untreated younger patients with CLL. We describe measurable residual disease (MRD) levels in E1912 over time and correlate them with clinical outcome. Undetectable MRD rates (<1 CLL cell per 104 leukocytes) were 29.1%, 30.3%, 23.4%, and 8.6% at 3, 12, 24, and 36 months for FCR, and significantly lower at 7.9%, 4.2%, and 3.7% at 12, 24, and 36 months for IR, respectively. Undetectable MRD at 3, 12, 24, and 36 months was associated with longer progression-free survival (PFS) in the FCR arm, with hazard ratios (MRD detectable/MRD undetectable) of 4.29 (95% confidence interval [CI], 1.89-9.71), 3.91 (95% CI, 1.39-11.03), 14.12 (95% CI, 1.78-111.73), and not estimable (no events among those with undetectable MRD), respectively. In the IR arm, patients with detectable MRD did not have significantly worse PFS compared with those in whom MRD was undetectable; however, PFS was longer in those with MRD levels <10−1 than in those with MRD levels above this threshold. Our observations provide additional support for the use of MRD as a surrogate end point for PFS in patients receiving FCR. In patients on indefinite ibrutinib-based therapy, PFS did not differ significantly by undetectable MRD status, whereas those with MRD <10−1 tended to have longer PFS, although continuation of ibrutinib would very likely be necessary to maintain treatment efficacy.",
author = "Wang, {Xin Victoria} and Hanson, {Curtis A.} and Tschumper, {Renee C.} and Lesnick, {Connie E.} and Esteban Braggio and Paietta, {Elisabeth M.} and Susan O'Brien and Barrientos, {Jacqueline C.} and Leis, {Jose Francisco} and Zhang, {Cong Christine} and Coutre, {Steven E.} and Barr, {Paul M.} and Cashen, {Amanda F.} and Mato, {Anthony R.} and Singh, {Avina K.} and Mullane, {Michael P.} and Harry Erba and Richard Stone and Litzow, {Mark R.} and Tallman, {Martin S.} and Shanafelt, {Tait D.} and Kay, {Neil E.}",
note = "Funding Information: This study was conducted by the ECOG-ACRIN Cancer Research Group (Peter J. O'Dwyer and Mitchell D. Schnall, Group Co-chairs) and supported by the National Cancer Institute of the National Institutes of Health under the following award numbers: U10CA180820, U10CA180794, U10CA180821, U10CA180888, UG1CA189821, UG1CA189859, UG1CA189863, UG1CA190140, UG1CA232760, UG1CA233180, UG1CA233230, UG1CA233253, UG1CA233290, and UG1CA233339; and by National Institutes of Health National Cancer Institute grant R01CA193541 (principal investigators Neil Kay and Tait Shanafelt). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Mentions of trade names, commercial products, or organizations do not imply endorsement by the US government. Funding Information: Conflict-of-interest disclosure: R.S. reports grants and personal fees from AbbVie and Agios; grants from Arog; and personal fees from Actinium, Astellas, Argenx, AstraZeneca, Biolinerx, Daiichi-Sankyo, Elevate, Gemoab, Hoffman LaRoche, Janssen, Macrogenics, Novartis, Otsuka, Pfizer, Syndax, Syntrix, Syros, Takeda, and Trovagene outside the submitted work. E.B. reports consulting fees from DASA. S.E.C. has received institutional research funding from AbbVie, Acerta, Gilead, Janssen, Pharmacyclics, and Takeda; has served on the Data Safety Monitoring Committee (DSMC) for Beigene and the Clinical Trial Steering Committee for Acerta; has been a consultant for AbbVie, Adaptive, Astellas, AstraZeneca, Genentech, Gilead, Janssen, and Pharmacyclics; has received honoraria from Janssen, Pharmacyclics, (CME accredited) Imedex, and Medscape and travel expenses from AbbVie, Beigene, Genentech, Janssen, and Pharmacyclics; and has served as an expert witness for Genentech. P.M.B. has been a consultant for Pharmacyclics, AbbVie, Genentech, Gilead, AstraZeneca, Bayer, Merck, Celgene/BMS, Morphosys, TG Therapeutics, and Seattle Genetics. T.D.S. has received research support from Pharmacyclics, Genentech, and AbbVie. N.E.K. has served on the advisory boards of AbbVie, AstraZeneca, Cytomx Therapy, Dava Oncology, Juno Therapeutics, Oncotracker, Pharmacyclics, and Targeted Oncology and on the DSMCs of Agios Pharm, AstraZeneca, BMS-Celgene, Cytomx Therapeutics, Morpho-sys, and Rigel; and has received research funding from AbbVie, Acerta Pharma, Bristol Meyer Squib, Celgene, MEI Pharma, Pharmacyclics, Sunesis, TG Therapeutics, and Tolero Pharmaceuticals. A.R.M. has received research support from TG Therapeutics, Pharmacyclics, AbbVie, Johnson and Johnson, Acerta, AZ, Regeneron, DTRM Bio Pharma, Sunesis, Loxo Oncology Adaptive; and has served on advisory boards and the DSMCs and as a consultant for TG Therapeutics, Pharmacyclics, AbbVie, Johnson and Johnson, Acerta, AZ, DTRM Bio Pharma, Sunesis, and Adaptive. M.S.T. has received research funding from AbbVie, Cellerant, Orsenix, ADC Therapeutics, Biosight, Glycomimetics, Rafael Pharmaceuticals, and Amgen; has served on the advisory boards of AbbVie, BioLineRx, Daiichi-Sankyo, Orsenix, KAHR, Rigel, Nohla, Delta Fly Pharma, Tetraphase, Oncolyze, Jazz Pharma, Roche, Biosight, and Novartis; and has received royalties from UpToDate. H.E. has received research funding from AbbVie, Agios, Amgen, Daiichi Sankyo, Forma, Forty Seven/Gilead, Glycomimetics, ImmunoGen, Jazz, Macrogenics, and Novartis. S.O. has received research support from Kite, Regeneron, and Gilead; has received research support and served as a consultant for Gilead, Pharmacyclics, TG Therapeutics, Pfizer, and Sunesis; and has been a consultant to Amgen, Astellas, Celgene, GSK, Janssen Oncology, Aptose Biosciences Inc, Vaniam Group LLC, AbbVie, Alexion, Verstem, Eisai, Juno Therapeutics, Vida Ventures, Autolus, Johnson and Johnson, and Merck. J.C.B. has received research funding from Oncternal and Velosbio and has been a consultant to AbbVie, AstraZeneca, Pharmacyclics/AbbVie, and Kite/Gilead. X.V.W., C.A.H., R.C.T., M.R.L., A.K.S., A.F.C., E.M.P., C.E.L., R.C.T., M.P.M., J.F.L., and C.C.Z. declare no competing financial interests. Funding Information: This study was conducted by the ECOG-ACRIN Cancer Research Group (Peter J. O'Dwyer and Mitchell D. Schnall, Group Co-chairs) and supported by the National Cancer Institute of the National Institutes of Health under the following award numbers: U10CA180820, U10CA180794, U10CA180821, U10CA180888, UG1CA189821, UG1CA189859, UG1CA189863, UG1CA190140, UG1CA232760, UG1CA233180, UG1CA233230, UG1CA233253, UG1CA233290, and UG1CA233339; and by National Institutes of Health National Cancer Institute grant R01CA193541 (principal investigators Neil Kay and Tait Shanafelt). Publisher Copyright: {\textcopyright} 2021 American Society of Hematology",
doi = "10.1182/blood.2020010146",
journal = "Blood",
publisher = "American Society of Hematology",
T1 - Measurable residual disease does not preclude prolonged progression-free survival in CLL treated with ibrutinib
AU - Wang, Xin Victoria
AU - Hanson, Curtis A.
AU - Tschumper, Renee C.
AU - Lesnick, Connie E.
AU - Braggio, Esteban
AU - Paietta, Elisabeth M.
AU - O'Brien, Susan
AU - Barrientos, Jacqueline C.
AU - Leis, Jose Francisco
AU - Zhang, Cong Christine
AU - Coutre, Steven E.
AU - Barr, Paul M.
AU - Cashen, Amanda F.
AU - Mato, Anthony R.
AU - Singh, Avina K.
AU - Mullane, Michael P.
AU - Erba, Harry
AU - Stone, Richard
AU - Litzow, Mark R.
AU - Tallman, Martin S.
AU - Shanafelt, Tait D.
AU - Kay, Neil E.
N1 - Funding Information: This study was conducted by the ECOG-ACRIN Cancer Research Group (Peter J. O'Dwyer and Mitchell D. Schnall, Group Co-chairs) and supported by the National Cancer Institute of the National Institutes of Health under the following award numbers: U10CA180820, U10CA180794, U10CA180821, U10CA180888, UG1CA189821, UG1CA189859, UG1CA189863, UG1CA190140, UG1CA232760, UG1CA233180, UG1CA233230, UG1CA233253, UG1CA233290, and UG1CA233339; and by National Institutes of Health National Cancer Institute grant R01CA193541 (principal investigators Neil Kay and Tait Shanafelt). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Mentions of trade names, commercial products, or organizations do not imply endorsement by the US government. Funding Information: Conflict-of-interest disclosure: R.S. reports grants and personal fees from AbbVie and Agios; grants from Arog; and personal fees from Actinium, Astellas, Argenx, AstraZeneca, Biolinerx, Daiichi-Sankyo, Elevate, Gemoab, Hoffman LaRoche, Janssen, Macrogenics, Novartis, Otsuka, Pfizer, Syndax, Syntrix, Syros, Takeda, and Trovagene outside the submitted work. E.B. reports consulting fees from DASA. S.E.C. has received institutional research funding from AbbVie, Acerta, Gilead, Janssen, Pharmacyclics, and Takeda; has served on the Data Safety Monitoring Committee (DSMC) for Beigene and the Clinical Trial Steering Committee for Acerta; has been a consultant for AbbVie, Adaptive, Astellas, AstraZeneca, Genentech, Gilead, Janssen, and Pharmacyclics; has received honoraria from Janssen, Pharmacyclics, (CME accredited) Imedex, and Medscape and travel expenses from AbbVie, Beigene, Genentech, Janssen, and Pharmacyclics; and has served as an expert witness for Genentech. P.M.B. has been a consultant for Pharmacyclics, AbbVie, Genentech, Gilead, AstraZeneca, Bayer, Merck, Celgene/BMS, Morphosys, TG Therapeutics, and Seattle Genetics. T.D.S. has received research support from Pharmacyclics, Genentech, and AbbVie. N.E.K. has served on the advisory boards of AbbVie, AstraZeneca, Cytomx Therapy, Dava Oncology, Juno Therapeutics, Oncotracker, Pharmacyclics, and Targeted Oncology and on the DSMCs of Agios Pharm, AstraZeneca, BMS-Celgene, Cytomx Therapeutics, Morpho-sys, and Rigel; and has received research funding from AbbVie, Acerta Pharma, Bristol Meyer Squib, Celgene, MEI Pharma, Pharmacyclics, Sunesis, TG Therapeutics, and Tolero Pharmaceuticals. A.R.M. has received research support from TG Therapeutics, Pharmacyclics, AbbVie, Johnson and Johnson, Acerta, AZ, Regeneron, DTRM Bio Pharma, Sunesis, Loxo Oncology Adaptive; and has served on advisory boards and the DSMCs and as a consultant for TG Therapeutics, Pharmacyclics, AbbVie, Johnson and Johnson, Acerta, AZ, DTRM Bio Pharma, Sunesis, and Adaptive. M.S.T. has received research funding from AbbVie, Cellerant, Orsenix, ADC Therapeutics, Biosight, Glycomimetics, Rafael Pharmaceuticals, and Amgen; has served on the advisory boards of AbbVie, BioLineRx, Daiichi-Sankyo, Orsenix, KAHR, Rigel, Nohla, Delta Fly Pharma, Tetraphase, Oncolyze, Jazz Pharma, Roche, Biosight, and Novartis; and has received royalties from UpToDate. H.E. has received research funding from AbbVie, Agios, Amgen, Daiichi Sankyo, Forma, Forty Seven/Gilead, Glycomimetics, ImmunoGen, Jazz, Macrogenics, and Novartis. S.O. has received research support from Kite, Regeneron, and Gilead; has received research support and served as a consultant for Gilead, Pharmacyclics, TG Therapeutics, Pfizer, and Sunesis; and has been a consultant to Amgen, Astellas, Celgene, GSK, Janssen Oncology, Aptose Biosciences Inc, Vaniam Group LLC, AbbVie, Alexion, Verstem, Eisai, Juno Therapeutics, Vida Ventures, Autolus, Johnson and Johnson, and Merck. J.C.B. has received research funding from Oncternal and Velosbio and has been a consultant to AbbVie, AstraZeneca, Pharmacyclics/AbbVie, and Kite/Gilead. X.V.W., C.A.H., R.C.T., M.R.L., A.K.S., A.F.C., E.M.P., C.E.L., R.C.T., M.P.M., J.F.L., and C.C.Z. declare no competing financial interests. Funding Information: This study was conducted by the ECOG-ACRIN Cancer Research Group (Peter J. O'Dwyer and Mitchell D. Schnall, Group Co-chairs) and supported by the National Cancer Institute of the National Institutes of Health under the following award numbers: U10CA180820, U10CA180794, U10CA180821, U10CA180888, UG1CA189821, UG1CA189859, UG1CA189863, UG1CA190140, UG1CA232760, UG1CA233180, UG1CA233230, UG1CA233253, UG1CA233290, and UG1CA233339; and by National Institutes of Health National Cancer Institute grant R01CA193541 (principal investigators Neil Kay and Tait Shanafelt). Publisher Copyright: © 2021 American Society of Hematology
N2 - E1912 was a randomized phase 3 trial comparing indefinite ibrutinib plus 6 cycles of rituximab (IR) to 6 cycles of fludarabine, cyclophosphamide, and rituximab (FCR) in untreated younger patients with CLL. We describe measurable residual disease (MRD) levels in E1912 over time and correlate them with clinical outcome. Undetectable MRD rates (<1 CLL cell per 104 leukocytes) were 29.1%, 30.3%, 23.4%, and 8.6% at 3, 12, 24, and 36 months for FCR, and significantly lower at 7.9%, 4.2%, and 3.7% at 12, 24, and 36 months for IR, respectively. Undetectable MRD at 3, 12, 24, and 36 months was associated with longer progression-free survival (PFS) in the FCR arm, with hazard ratios (MRD detectable/MRD undetectable) of 4.29 (95% confidence interval [CI], 1.89-9.71), 3.91 (95% CI, 1.39-11.03), 14.12 (95% CI, 1.78-111.73), and not estimable (no events among those with undetectable MRD), respectively. In the IR arm, patients with detectable MRD did not have significantly worse PFS compared with those in whom MRD was undetectable; however, PFS was longer in those with MRD levels <10−1 than in those with MRD levels above this threshold. Our observations provide additional support for the use of MRD as a surrogate end point for PFS in patients receiving FCR. In patients on indefinite ibrutinib-based therapy, PFS did not differ significantly by undetectable MRD status, whereas those with MRD <10−1 tended to have longer PFS, although continuation of ibrutinib would very likely be necessary to maintain treatment efficacy.
AB - E1912 was a randomized phase 3 trial comparing indefinite ibrutinib plus 6 cycles of rituximab (IR) to 6 cycles of fludarabine, cyclophosphamide, and rituximab (FCR) in untreated younger patients with CLL. We describe measurable residual disease (MRD) levels in E1912 over time and correlate them with clinical outcome. Undetectable MRD rates (<1 CLL cell per 104 leukocytes) were 29.1%, 30.3%, 23.4%, and 8.6% at 3, 12, 24, and 36 months for FCR, and significantly lower at 7.9%, 4.2%, and 3.7% at 12, 24, and 36 months for IR, respectively. Undetectable MRD at 3, 12, 24, and 36 months was associated with longer progression-free survival (PFS) in the FCR arm, with hazard ratios (MRD detectable/MRD undetectable) of 4.29 (95% confidence interval [CI], 1.89-9.71), 3.91 (95% CI, 1.39-11.03), 14.12 (95% CI, 1.78-111.73), and not estimable (no events among those with undetectable MRD), respectively. In the IR arm, patients with detectable MRD did not have significantly worse PFS compared with those in whom MRD was undetectable; however, PFS was longer in those with MRD levels <10−1 than in those with MRD levels above this threshold. Our observations provide additional support for the use of MRD as a surrogate end point for PFS in patients receiving FCR. In patients on indefinite ibrutinib-based therapy, PFS did not differ significantly by undetectable MRD status, whereas those with MRD <10−1 tended to have longer PFS, although continuation of ibrutinib would very likely be necessary to maintain treatment efficacy.
U2 - 10.1182/blood.2020010146
DO - 10.1182/blood.2020010146
JO - Blood
JF - Blood


text:
in: Mechanics, Persona 5, Persona 5 Strikers
The security level of Kamoshida's Palace at 15%
"Seems so. Just don't let it notice you beforehand... If it does, the Palace's security level will rise."
—Morgana, Persona 5
The Security Level is a mechanic in Persona 5.
2.2 Persona 5 Royal
2.3 Persona 5 Strikers
2.4 Persona O.A.
Persona O.A.
"Well, the security level will go back down if we can beat more enemies without getting noticed."
Palaces are highly guarded by Shadows protecting the Cognition of the Palace. The Security Level starts at 0% but can be raised if the protagonist fails to remain hidden from a non-scripted Shadow fight and is spotted. Additionally, running from a battle (or an enemy runs on their own volition) also increases the Security Level. The difficulty setting determines the rate at which the security meter goes up and down.
If the meter gets to yellow or red, the chance of finding Treasure Demons and Disaster Shadows increases, allowing the party to kill them for loot. However, the encounter rate will also increase and the party may fight several waves of Shadows at a time. When the Security Level reaches 100%, exploration is halted and the Phantom Thieves are forced to retreat immediately from the Palace, meaning they must come back on another day. The only exception to this rule (aside from Palaces after a calling card has been sent) is the Depths of Mementos, as the party will be locked inside it until they defeat Yaldabaoth. The party can lower the Security Level by ambushing Shadows and defeating them.
Revisiting the Palace on another day will reduce the meter a bit as well. The Security Level can also be subsided by Ichiko Ohya's Confidant ability (theoretically Ichiko reports unfavorable scoop about the owner of the current Palace to distract that person from noticing the party's activities in the Palace). If one has connected to the Thieves Guild, a request can be made to reduce the Security Level when it hits 100%.
When the Phantom Thieves send a calling card, the Palace's security meter is fixed at 99% and will not boot the party out even when being discovered and ambushed by an enemy. The party can fight Shadows and lower the Security Level even after the calling card has been sent, although they can only reduce it down to 70%, and it will have no effect on the upcoming boss fight. However, it will stop Shadows from respawning if lowered sufficiently before reaching the Treasure room.
The Palace's current Security Level is depicted via a security meter, which is displayed when using the Third Eye ability. The security meter also features a stylized portrait of the Palace ruler. Depending on whether the Thieves have personally encountered the Palace ruler's Shadow or not when using the ability, their portrait will either depict the ruler's real-world self, partially shrouded in darkness, or the ruler's Shadow Self. Exceptions of this rule are: Suguru Kamoshida, since it is impossible to use Third Eye before meeting his Shadow Self; Futaba Sakura, whose Shadow Self's portrait remains unused, Masayoshi Shido, whose Shadow Self not only has multiple outfits and forms but is also never encountered or even seen before he is actually fought (Even the cutscene in which his Shadow self reacts to his calling card has it remain in darkness.) and Takuto Maruki, whose portrait is represented by a black humanoid figure until he is personally met in the Palace and is not a Shadow Self but a physical human.
In Persona 5 Royal, the security meter starts at 40% instead of 0%. In addition to this, if the security meter reaches 100%, the Phantom Thieves will not be forced to retreat from the Palace.
After the calling card has been sent, the security meter is fixed at 100% instead of 99%. Fighting shadows will only lower the Security Level down to 80%, rather than 70%.
Ichiko Ohya's Confidant abilities are also altered to accommodate this change; lowering the starting security meter, as well as preventing increase after a successful ambush, etc., unlike in the original where the security meter only lowers after a day has passed.
Security Level works very similarly to how it functions in the original Persona 5. The Security Level starts at 0% and increases or decreases depending on the player's actions in the Jail. Security Level resets to 0% when leaving the Jail.
Security Level change
Preemptive attack from an enemy Shadow +18%
Spotted by a searchlight +14%
Fleeing from battle +13%
Spotted by an enemy Shadow (Merciless only) +5%
Winning a battle -8%
Using a Purifying Ash -10%
Using a Mega Purifying Ash -30%
Much like in Persona 5, the Security Level can be displayed by activating Third Eye. In this game, portraits of Shadow Selves are not used alongside the Security Level, instead simply displaying a generic alarm icon. The Security Level gauge's color becomes blue, then turns yellow and red once Security Level reaches 30% and 70% respectively.
Once the Security Level reaches 30%, treasure chests will have barriers on them, preventing the party from opening them until the Security Level decreases below 30%. Enemies will also respawn on the map after a few other battles, though this allows the party to battle an infinite number of enemies in a single Jail visit as long as the Security Level is kept 30% or higher. Another benefit of high Security Levels is that the rate of Treasure Demon appearances increases. If the party raises the Security Level to 100%, they will be forced to leave the Jail; however, there are no adverse effects to being forced to leave a Jail early beyond having to restart at a checkpoint. If playing on Merciless difficulty, once the Security Level reaches 30%, the party will not be able to escape from normal battles, with red KEEP OUT barriers appearing as if the party was in a forced encounter.
During key events, such as when the Phantom Thieves are infiltrating the Monarch's castle and after sending the Calling Card, the Jail's Security Level will be fixed at 99%, and will not increase or decrease during this time regardless of the player's actions. The aforementioned effects of high Security Levels also do not apply in this time.
The security level slowly goes up over time while the party is in Mementos. After 8 hours of searching, the security level will reach 100%, and the party will be forced to retreat.
Boss enemies can only appear once per visit after an hour has passed (roughly 12% on the security meter.)
Kamoshida's real self (Impossible to view in-game)
Shadow Kamoshida, Asmodeus
Madarame's real self
Shadow Madarame, Azazel
Kaneshiro's real self
Shadow Kaneshiro, Bael
Futaba's real self
Shadow Futaba (Unused)
Wakaba's real self (Unused)
Okumura's real self
Shadow Okumura, Mammon
Sae's real self
Shadow Sae, Leviathan
Masayoshi Shido's real self
The general public, as represented in Mementos
Maruki as a hidden figure
Maruki

redpajama_set_name: RedPajamaCommonCrawl


Valve has revealed the top ten sellers for the first of two full weeks of store-wide discounts during Steam's holiday sale.
Several heavy hitters were vying for the top spot, but in the end first-person hack and slash Chivalry: Medieval Warfare beat them all.
Skyrim would have likely surpassed the indie, but its franchise daily deal landed on the last day of the period, meaning more than half of its featured time is counted toward next week's list. Expect to see it again at that point.
Borderlands 2, Far Cry 3, ArmA II, the THQ Collection, and Call of Duty: Black Ops II all hold the distinction of back to back appearances.


It seems that the dependable Dev-Team has successfully managed to jailbreak iPhone 3GS running iPhone OS 3.1 without upgrading the Baseband version.
Both the links available in the Tweet takes to the screenshot displayed below which shows iPhone 3GS running OS 3.1 have the same old baseband version 04.26.08. Which means using the method used by the dev-team, users will be able to unlock iPhone 3gs using the same UltraSn0w.
So we are a step closer to having our hands on to PwnageTool update or any other new tool coming from the house of the Dev-Team to safely update our iPhone 3GS to OS 3.1 and then jailbreak & Unlock it.
Lets wait for the Dev-Team announcement on their official blog to jailbreak iPhone 3GS OS 3.1. We will keep you posted as there comes any update. So, stay tuned at iphoneheat.com.


GetHuman-tesshum's next move: call LinkedIn.
I manage a company page on LinkedIn and we keep getting jobs ads associated with our page that non of our HR representatives have uploaded. Even though they are jobs for our company, the job postings have not been created or approved by us, and the formatting looks very unprofessional. For example, this listing: https:**www.linkedin.com*jobs*view**************How can we stop these from appearing on our jobs list?
GetHuman-tesshum did not yet indicate what LinkedIn should do to make this right.
We are waiting for GetHuman-tesshum to fix the problem and share the solution with the rest of us customers.
See how GetHuman-tesshum fixes it.


Catalysis will continue to shape the chemical and energy industries as we attempt to shift from petroleum-based feedstocks towards renewable resources. Understanding catalysis at the molecular level requires a combination of catalyst characterization, as well as kinetic, isotopic, and theoretical studies to elucidate reaction mechanisms and develop structure-function relationships. Any relevance of theoretical investigations of catalysts depends upon faithful models of the catalytic environment (e.g. metal particles, metal-support interfaces, co-adsorbed species, solvent) present during steady-state catalysis. Here, we examine the activations of strong chemical bonds found in O2, NO, and CO – necessary steps in oxidation chemistry (of CO and alkanols), reduction of toxic NO to environmentally-inert N2, and formation of large-chain hydrocarbons from CO-H2 mixtures (Fischer Tropsch synthesis, FTS). Direct dissociations of these species have large activation barriers on low-index surfaces of supported metal catalysts, which are prevalent on large (>3 nm) clusters. These kinetic hurdles can represent the noble nature of the metal catalyst (O2 activation on Au), high coverages of co-adsorbed intermediates (high coverages of chemisorbed NO on Pt during NO-H2 reactions), and/or the strength of the chemical bonds (CO activation on Ru or Co). Previous experimental and theoretical studies of single-crystal surfaces have demonstrated that defect sites, which are under-coordinated metal atoms, significantly lower direct dissociation barriers on nearly bare surfaces. We show, however, that such sites are often blocked by strongly-bound adsorbates (e.g. chemisorbed CO) and on crowded surfaces, bonds instead activate via bimolecular reactions that weaken the bond prior to cleavage. These case studies demonstrate the necessity of understanding the nature of the catalyst through kinetic and spectroscopic studies in order to model reactions at conditions relevant to practical catalysis—by considering the impacts of co-adsorbed species (which may be present at near saturation coverages), particle morphology (to assess any contributions of defect sites), and solvent (when present). These studies also offer valuable and transferable insights into chemistry on metal surfaces, which can ultimately lead to the development of new materials for the conversion of biomass and natural gas derived feedstocks into value-added fuels and chemicals.


Great breakfast, friendly service. Comfortable and welcoming. Rolls and bread made in-house daily.
7:00 a.m. - 7:30 p.m.
7:00 a.m. - 1:30 p.m.
2 of the largest covered aviaries in the world and a waterfowl preserve are located at Gooseneck Hill Waterfowl Sanctuary with over 300 geese, ducks and swans even having the endangered NeNe geese.


text:
Aspects of Scientific Explanation and other Essays in the Philosophy of Science is a 1965 book by the philosopher Carl Gustav Hempel. It is regarded as one of the most important works in the philosophy of science written after World War II.

Reception
The historian Peter Gay wrote that Aspects of Scientific Explanation was "seminal" and "indispensable", writing that Hempel persuasively argued that "the logic of history and that of the natural sciences are the same." Gay observed that Hempel's essay "The Function of General Laws in History" is a "much debated classic". The philosopher Michael Friedman described the book as one of the most important works in philosophy of science written after World War II.

See also
 Models of scientific inquiry

References

Bibliography
Books

1965 non-fiction books
American non-fiction books
Books by Carl Gustav Hempel
English-language books
Essay collections
Philosophy of science literature

redpajama_set_name: RedPajamaWikipedia


text:
Oxenfree 2 Finds Clever Ways to Expand the Series' Intriguing World
byJonathon Dornbush
Posted Oct. 5, 2021, 6:26 p.m.
There was something quite special about the original Oxenfree. Night School Studio's walk-and-talk adventure game lets players uncover the mysteries of Edwards Island, fall for (or be sassy to) its ensemble cast of characters, and make plenty of dialogue choices along the way as things got creepier and creepier.
Thanks to a hands-off preview session with Oxenfree 2, the sequel isn't looking to break what isn't broken. Instead, it seems the developers, nearly all of whom are back from the original, have found clever ways to deepen the base of Oxenfree's world and spin it out into surprising new attempts to break our brains a little, and introduce some endearing new characters to boot.
Oxenfree II is set in the same world as the original, but focuses on a brand new cast, with players taking on the role of environmental researcher Riley. She's come back home to the town of Camena to figure out why electronic equipment is being affected by strange radio signals. Unsurprisingly, Camena isn't that far from Edwards Island, and the supernatural events that begin to unfold over one night threaten this charming coastal town.
A new cast doesn't mean your time with the original Oxenfree will be for nought, whether you played years ago, revisit before the sequel, or are just picking it up now. There will be plenty of acknowledgements to the first game's story, and in fact, the developers have even been updating the original Oxenfree on PC with new audio clips that help bridge the story of this sequel's villains, Parentage, with the original game.
But the focus seems to primarily be on Riley's story. Her confident tone, mixing a bit of snark with an undertone of warmth, fits right at home in Night School's chatty world. The first game's dialogue blended West Wing-paced chatter with Veronica Mars-esque wit, and though these characters are older, that blend still feels right at home as Riley and her friend Jacob explored Camena in the section of gameplay I saw.
At the end of the day, a game like Oxenfree will live or die by how charming, or at least interesting, these characters are, particularly given that players are constantly making dialogue choices. Thankfully, Oxenfree II seems to continue to nail that tone of realistic, casual conversation that Night School excelled at in both the original and Afterparty, and Oxenfree II looks to make the player's choices matter even more this time around. A small example we saw involved Riley trying to cross an ultimately un-jumpable gap by, well, jumping it, falling to a rock a little below. Jacob takes a much safer route, climbing down a rock wall to help her back up. Even a small decision like that could lead to new permutations in conversation, and I'm fascinated to see how scenes can play out differently, as a moment like this was something emblematic of what the developers strove for in the sequel.
"It was definitely an initial goal of ours: we wanted more choices that aren't dialogue-based. We wanted you to be making choices with your physical decisions about what you're doing and how you want to go about that," Studio Lead Writer Adam Hines told IGN. "It also pushed us to design the environments in ways that would allow those types of moments to actually occur. There's very few times when there's just one path to get up or down. You always have more forks in the road and more micro-choices on how to get to certain spots."
Another particular highlight demonstrating the relatable nature of the characters came when Jacob and Riley played a game in which they told each other a story word by word.
I love moments like that, and have in Night School's past games, so if the team can continue to deliver those personal, witty scenes like they do here, I can't wait to see what else we might discuss while exploring Camena.
That little game, more importantly, stems from a character beat - Jacob is pretty freaked out by everything happening, and the game helps to calm his nerves. It's so key for moments like that to not feel kitschy and to be rooted in who these characters are, and it made me appreciate the scene all the more. I guess it's also worth mentioning that Jacob was nervous because, well, he and Riley had ended up in 1899.
Gotta Go Back in Time
You see, time tears have started opening up around Camena. They'll allow Riley and her companions to journey through time to a point that will hopefully offer some assistance in their journey. In this case, the duo, while venturing through the tunnels that spread all throughout Camena (a surely handy exploration device for a world the developers estimate is about 2.5-3 times bigger than Edwards Island, though they noted players shouldn't necessarily expect a sequel that's three times as long to play), discovers a time tear that brings them back all the way to 1899, back before the mines were abandoned after a major collapse. Thankfully, in this time period, there's a working elevator that, through a bit of quick puzzle solving, Riley and Jacob get moving in order to help them reach another time tear and return to their point of origin. There's only one problem - they're trying to pull off this bit of platforming and puzzle solving as the mines are, indeed, crumbling around them.
I'm certainly a sucker for interdimensional rifts, and while Oxenfree is using them on a much smaller scale than, say, Ratchet and Clank, it seems no less integral to Oxenfree II's story. Not only does it allow for a game so focused on its characters and location to deepen our understanding of those facets in ways that just couldn't be done on a standard timeline, it also lends some appreciable grey area to Riley's actions. Did her and Jacob's meddling happen to cause the mine collapse, or did they just happen to be in the right place at the wrong time? I hope Oxenfree II doesn't necessarily answer questions like that - it's the type of time-loopy rabbit hole a story like this allows for, and I love the potential this one sequence promises.
The time tears are as exciting a potential route to explore as a player as they seemingly were to develop. "In the first game, the lion's share of choice and interaction came through dialogue... but these time tears have become something really exciting for us, because it is the type of thing where, as the night degrades and as things are breaking down, all of those spaces that you're seeing will have some new things that pop up inside of them that change contextually based on where in the night the game is," Studio Lead Sean Krankel said.
"You can conceivably go explore most of Camena and then come back to a space that you're in and things will have been changed a little bit," he continued.
This time tear is one placed along the main narrative path, and while the tears will certainly come into play there, players can expect to find some of them, as well as other sidequest opportunities throughout Camena.
"[Time tears] are definitely not all directly tied to the exact story that you're going through now," Hines explained. "A lot comes out of the walkie talkie side quest that you can encounter and choose to do. Those side quests will all be roughly related to the event that's happening in the night, but the people's specific problems go off in wild and weird ways that you have to sometimes go around the beaten path to solve."
But my introduction to time tears also represents a scene coming about an hour or so into the sequel's story that feels bigger than most of what the original Oxenfree could pull off. Years later, Night School seems to have learned plenty about how to bring these characters and this world to life, not just in terms of the obviously improved character model fidelity, but in the complexity of sequences that also retain the haunting, beautiful art style of the original.
And it's not just the scale that seems to be a focus for Night School; the more expansive size of Camena doesn't just make for a bigger world - it lets Night School fill the town with more interesting objectives, side quests, and more. The demo showed a couple of ways in which the developers are pulling this off.
The first is the use of a walkie-talkie that not only allows for a wider group of characters to interact with the player wherever they are in Camena, but also gives the player agency in initiating conversations, whether to remind them of side quests, or learn more insight into characters along the way. It's a nice bit of expansion to Night School's underlying theme of choice - not only do you get to choose what to say in conversations, now you have a bit more choice in when you want to talk to some characters.
"Having the walkie talkie in there and allowing the player to start conversations with people that aren't on screen, with characters that they've met and want to tag in with and see how they're doing or ask for advice or something, was a big nut that felt great to crack, the ability to start a conversation to drive it in the way that you want to," Hines said.
Additionally, movement and exploration has been expanded thanks to the inclusion of a rope players acquire early in the game. Riley having an ex-military background gives some plausibility to her more adventurous leaning, and players can rely on that skill and the rope to navigate to bits of Camena you wouldn't otherwise be able to reach. It doesn't suddenly transform Oxenfree into a twitchy platformer, but it again offers the player more choice, and, just as importantly, more methods of satisfying their curiosity about what secrets Camena holds.
"There's absolutely more traversal built into the design, but it's not heavy platforming and double jumps and swinging across things," Krankel explained. "It's more about wanting the player to parse out the map differently and not just feel like they're pressing from left to right and talking."
My short time seeing Oxenfree II certainly indicated that there's a lot more than just walking left and right and talking. As Night School noted, Oxenfree isn't transforming into some unexpected genre, unrecognizable from its predecessor. Instead, it's aiming to deepen the promise of player agency and choice within an authored world and story, and do that in ways that extend beyond choosing dialogue options during a conversation. I, of course, still need to play Oxenfree II, and see how that sense of choice extends to the full adventure, but the promise of its expanded potential seemed clear in just this brief section. I hope the rest of Camena is just as memorable a place to explore.
Jonathon Dornbush is IGN's Senior Features Editor, PlayStation Lead, and host of Podcast Beyond! He's the proud dog father of a BOY named Loki. Talk to him on Twitter @jmdornbush.
Diablo: Immortal Investigated by Law Firm Over Certain In-Game Purchase
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1 week, 3 days Comments
Disney Lorcana: The First Chapter Release Date and Starter Decks Announced
Activision Blizzard Says NetEase Declined an Offer to Extend Publishing Deal in China


text:
Illegal pet monkey quarantined after biting Calif. woman
By Christine Roberts
Sep 10, 2012 | 8:06 AM
Exotic animals like the Javan macaque monkeys are illegal in California. (Paul Kennedy/Getty Images/Lonely Planet Image)
A monkey kept illegally as a pet has been quarantined after she bit the hand that fed her - Frosted Flakes and juice.
Authorities seized the Javan macaque, named Jennaeve, after she sunk her teeth into a Paso Robles, Calif. woman several times, The Tribune reported.
The 22-year-old primate that may belong to the woman's boyfriend was kept in a dog kennel inside of the pair's trailer and fed a diet of the sugary cereal and juice - a diet that has made the monkey obese.
The San Luis Obispo County division of Animal Services learned of the illegal pet in late August when the unidentified woman sought medical attention for several serious bite wounds on her arm and hand.
It was not the first time the monkey had bit her, officials said.
"This kind of animal is never meant to be kept domestically," Animal Services manager Eric Anderson told the Orlando Sentinel, explaining that macaques are capable of dog-like bites.
"And that is entirely the wrong kind of diet," he added.
The California Department of Fish and Game is currently investigating the incident, and the owner faces up to six months in jail and a $1,000 fine if convicted of unlawful possession of a restricted species, according to The Tribune.
The macaque is being quarantined for a 60-day period at the animal rescue program Zoo to You in Paso Robles.
David Jackson, director of Zoo To You, said that the macaque is doing well after finally receiving proper treatment.
"Like anybody, she is a little overwhelmed being in a new place surrounded by new people," Jackson said. "But she is getting the proper diet of fruits, vegetables and monkey chow, sunlight, room to roam and a place to hide and climb."
croberts@nydailynews.com


Well this week, the majority of my quest runs were with characters between the level 8 to 16 range, which is I have titled the runs this week as "middle of the road." I started the week by taking Erdrique (Level 9 Rogue) through Tangleroot Gorge. One thing I have noticed with Erdrique during this particular heroic life is that he seems to be leveling a little faster. Well, actually, I'm not sure "faster" is the best term to use. In Erdrique's previous lives he was able to keep up with maximizing out his slayer areas at level. Well currently Erdrique is level 9 and still has yet to max out Tangleroot Gorge and has barely started Three Barrel Cove. I think this is primarily do to running a large number of Cannith Challenges, which I hadn't really done before. In any case, he is getting close to finishing up Tangleroot Gorge slayers and I hope finish those this weekend. Monday afternoon, I took Erdrique out into Three Barrel Cove and made my way through Brood of Flame. Later that night, I logged on with Kanndar (Level 12 Paladin) and took him through Devils Assault on hard and Taming the Flames on Elite.
Erdrique getting up close and personal with Kroshk in Tangleroot Gorge.
Erdrique making his way through Captain Dustdyn's camp in Three Barrel Cove on his way to the Fire Caves.
Erdrique making his way through the Fire Caves to complete the quest Brood of Flame.
Kanndar taking it to the devils in Devil Assault.
Kanndar working his way through Taming the Flames.
On Tuesday, I started the day off with a rare run of an epic level character for the week, Kolll (Ranger/Shiradi Champion Level 22). I took Kolll through the King's Forest for my morning slayer run prior to work. Later that afternoon and that night, I logged on with Hamllin (Level 16 Fighter) and I took him into the Red Fens for some quick slayer runs as I continue to plow my way through that area. Later that night, I took Hamllin through the Cursed Crypt on elite and had a fun time dealing with Maldetto and his various minions. I was surprised with my run through the Cursed Crypt and had an interesting time using Hamllin's enhancements. After I ran the Cursed Crypt, I too Hamllin into the challenge Extraplanar Palace: Labor Shortage.
Kolll hunting for the drow in the King's Forest.
Hamllin slicing his way through the spiders of the Red Fens.
Hamllin making his way through the Cursed Crypt.
Hamllin protecting his kobolds in Labor Storage.
Wednesday was a light day of questing. I actually kicked off the morning with some adventuring with my spirit shaman, Ragnar, in Neverwinter Nights II Original Campaign. This was actually quite fortunate because the Patch 3 to Update 25 was actually scheduled to be put in place starting at 7 am. Later in the afternoon though, after my launcher and files updated, I logged on with Erdrique and took him back to Barrel's Bottom and headed into the quest Guard Duty. After that, I called it a night and spent the rest of the day with my lovely wife for our regularly date night.
Rangar and his party running into some entanglements in Neverwinter.
Erdrique preparing for the boarding party.
To round out the week, I took Kanndar through the jungles of Sorrowdusk Isle and continued his quest of maxing out that area. I continued with slayers that afternoon when I logged back on with Hamllin and took him through the Red Fens. That night, I logged on with Charlock (Level 14 Fighter), I decided to start the Ruins of Threnal quests with him. So, I picked up the quest, In Need of Supplies, and started out the Western Excavation chain. After completing In Need of Supplies, I then knocked out The Rescue and Secure the Area on elite. Once those were complete, I then took Charlock into House Cannith and ran the challenge Extraplanar Palace: Labor Shortage. I called it a night after that.
Kanndar fighting Barxer in Sorrowdusk Isle.
Hamllin fighting the vine stalkers in the Red Fens.
Charlock enters the Western Excavation for the first time and weighs his enemies.
Charlock preparing to fight the flesh renders in Threnal.
Charlock works his way to take out the denizens of the Western Excavation.
Charlock clearing the way for the kobolds.
So this week was truly dominated by runs with characters between levels 8 and 16. Even with that said, it was quite diverse week with runs from Three Barrel Cove, to the Necropolis, to Threnal. I think having a week like that, keeps me on my toes :). Thanks for reading everybody and I hope you all had a great week as well and will have a wonderful weekend too!!
Over this past weekend, the quest runs and other DDO activities I worked on were pretty much dominated by playing Erdrique (Level 6 Rogue). However, I did get some runs in with Cantlin (Level 12 Sorcerer) and Tuhnn (Level 15 Bladeforged). I actually kicked off my weekend runs by taking Cantlin back into Sorrowdusk Isle. It was a little bit of deja vu for me concerning I had just taking Cantlin into Sorrowdusk Isle the night before. Have to love how schedules sometimes work like that . That afternoon, after I downloaded the patch, I took Erdrique into the quest, The Depths of Darkness. I didn't have any issues combating the enemies or completing the quest on elite. That night, I took Erdrique back into the Waterworks Slayers and then I completed the story line by completing Venn's Trail: Clan Tunnelworm and Venn's Trail: Venn's Fate. Prior to hitting up the Waterworks, I had spent quite a bit of time working on maintenance issues: auction house returns, breaking items down for crafting, dealing with my overflowing mailbox, and upgrading some of my crafted gear. So once I completed the Waterworks, I called it a night.
Cantlin sending a beam of fire towards the ogres.
Erd makes his way through the Depths of Darkness.
Erd making his way through the Waterworks.
Erd doing his best to dodge the lightning bolt in the Waterworks.
Erd coming acros the remains of Venn.
On Saturday, I logged back in with Erdrique and took him into the Waterworks Slayer area once again. Although I have the story arc complete on elite, I still needed to wrack up a number of kills out there. After I finished up the area, I then worked on the Sharn Syndicate Series on elite: Stand Your Ground, Dirty Laundry, Stormreaver Fresco, Bookbinder Rescue, Repossession, and Come Out and Slay. I didn't have any issues in these quests at all and enjoyed not having to worry about the traps in the Bookbinder Rescue or Repossession. Once those were done, I ran through challenge Dr. Rushmore's Mansion: Behind the Door and nearly found/opened all 16 doors. I was just one shy before the time ran out. But I did take out 3 of the bosses. After that run, I then completed the next quest in the Shan-to-Kor story arc, The Cloven Jaw Scourge: Caverns of Shaagh. And then I decided I wasn't done with hobgoblins so I headed out to Tangleroot Gorge and completed the Yarkuch's Warplans, after which I called it a night.
Erd helping out the Statwell brothers.
It is time to deal with the money launderers.
Erd patiently waiting for Zircon in Stormreaver Fresco.
Time to take care of the Sharn Syndicate inside the Bookbinder's home.
Erdrique paying Zircon back for his treachery.
Dealing with the Syndicate once and for all.
Erd rudely disrupting the mistress.
Making my way through the Caverns of Shaagh.
Erd looking for the war plans.
A Sunday, I decided to give Erdrique a break and logged on with Tuhnn. I took Tuhnn out into the Ruins of Threnal to work on some experience and some favor since those quests run from level 8 to 10 on normal. I was able to complete all of the Western Excavation on elite: In Need of Supplies, The Rescue, and Secure the Area.
Tuhnn coming across Derward finally.
Tuhnn looking for Derward again.
Interesting shrine in the Western Threnal.
So all in all, it was a pretty decent weekend. I wish I could have gotten more done on Friday night but I did have a lot of those "maintenance" activities to catch up on. I hope everybody else had a good weekend as well. Thanks for reading everybody and happy hunting!!
When one thinks of a champion for the enemy monsters or forces one typically thinks of a larger, ferocious, dangerous, and grueling enemy. The champion is typically brutish, powerful, and cunning. For the most part, I get this sense from the newly crowned mobs we encounter now on hard and elite difficulties in quests but while running Threnal West (In Need of Supplies) the other day with Erdrique (Level 11 Monk, although I was level 10 at the time of the quest) and came across a championed monster that I just don't recognize as a champion of the dungeon.
Erdrique coming across a black pudding as a monster champion in Threnal.
Now I know the above screenshot is bad as far as indicating that the black pudding being a monster champion but it was. Unfortunately you can't really see the crown because of the dead glass spider behind the black pudding. I thought I had taken a better screenshot. But in any case, the black pudding was indeed a monster champion for this instance and I just couldn't bring myself to see this thing as a champion for the enemies in here. I think this is the strangest monster champion I have encountered so far. So much for seeing that brutish and cunning beast..
My questing activities over this week included quest runs with Erdrique (Level 17 Druid), Hamllin (Level 11 Fighter), and Charlock (Level 13 Fighter) and slayer runs with Hamllin, Suppply (Level 8 Paladin), Wapoyei (Level 23 Cleric/Exalted Angel), and Sludgge (Level 20 Rogue/Shadowdancer). On Monday, I started the week off with some slayer runs with Hamllin. Since it was Labor Day, I actually logged into DDO later than my usual weekday run because I didn't have to go into the office, although my wife I did have to go to work that morning (which is why I still logged in). Hamllin is extremely far behind in his slayer runs when compared to Erdrique. He is level 11 and is still finishing up the Tangleroot Explorer zone. After than he will need to completed Three Barrel Cove, Searing Heights, and Sorrowdusk Isle to be approximately where he should be. I just haven't taken him into these zones as much as I have with Erdrique. After running around Tangleroot for a little while, I then logged out for awhile but logged back on later that night, with Hamllin once again. It was one of those scheduling days where I actually had the same character scheduled for a morning slayer run, an afternoon questing session, and a quest run for the evening. So, I decided to start the Ruins of Threnal with Hamllin and I took him into the Western Excavation and completed In Need of Supplies and The Rescue. While I was working on those quests, I was also multitasking and playing with my digital D&D group as well. Not a bad night of questing for Labor Day :).
Hamllin wondering around in Tangleroot and wondering what is brewing.
Hamllin fighting a horde of spiders at the entrance to the Western Ruins.
Hamllin making his way to Derward.
On Tuesday, my questing started with my slayer run prior to work with Suppply who was working in Three Barrel Cove. After I collected some pirate slayers I headed off to work. I was scheduled to play Erdrique for my afternoon run, so I took him into the Orchard of the Macabre and into the Desecrated Temple of Vol. On elite, I figured I might have some trouble in the trapped hallway with the spinning blade traps and fire dart traps but I was able to easily navigate my way through it without much difficulty. The rest of the quest I handled without any issues. I logged out after that run and made some dinner. Now on Labor Day, I was scheduled to do a mid-day run with Hamllin but I never got a chance to do that run so I took that opportunity to finish the Western Excavation and completed the quest Secure the Area. Hamllin blasted through that quest easily and after that I logged on with Charlock and took him into the Tomb of the Shadow Knight where I made my way past his many traps and took on his mummy guardian. After that, I logged out for the night.
Suppply fighting the orcs in Three Barrel Cove.
Erdrique on the prowl on his way to the Desecrated Temple of Vol in the Orchard.
Erdrique noticing that the banner in the Desecrated Temple of Vol is the same as that in the Bloody Crypt.
Hamllin working on Securing the Area.
Charlock peering down the tunnels of the Crypt of the Shadow Knight.
For Wednesday, I was scheduled to take Wapoyei out into the High Road for my morning slayer run. So I ventured around out there looking for some slayers and rares. I still have a large number of journals to find out there so I'm going to have to print me off a map with their locations. After running around the High Road for a little while I logged out and headed off to work. When I got back home, I logged on with Hamllin who started on Eastern Excavation of Threnal and completed the first quest, The Library of Threnal. I didn't have any issues but that was the last run for the day as it was date night with the misses :).
Wapoyei having a grand time in the High Road with his two owlbears.
Hamllin battling Basthuul in the Library of Threnal.
Thursday morning, I took Sludgge out in the Ruins of Giantold to collect some Stormeye slayers. The rest of the day was dominated with runs with Erdrique who first ventured out into the Orchard of the Macabre and attempted to run the quest Flesh Maker's Laboratory. Key word their was attempted. I was progressing well through Flesh Maker's on elite up until I had to activate the two levers in the lightning tunnels. I hit the first lever without a problem but the second lever didn't go so well. I didn't realize how close I was to the lightning posts until my hirelings started dropping and then I dropped. Needless to say…I suffered a party wipe :(. I will have to attempt Flesh Maker's again this weekend. However, I did redeem myself!! That night, I logged back in with Erdrique and entered the quest Against the Demon Queen on elite on took the fight to Lailat. I thought for sure I would have problems in here but the quest went rather smoothly. I did get killed but I was still able to get myself back up and to complete the quest. So now I have all the level 12 quests completed on elite (minus the raids).
Sludgge approaching the Shavarath portal in Gianthold.
Erdrique burning up the rats on the mounds in the Orchards.
I suffered a tragic party wipe in Flesh Maker's laboratory…need some redemption!!
Erdrique takes on the forces of Lailat in her court.
So the questing over the week was active and I had a fun time. Looking forward to another fun time this weekend!!


text:
Oil price spike won't increase industry cleanup spending: Alberta energy minister
October 8, 2021 2:33 PM The Canadian Press0 Comments
Alberta Energy Minister Sonya Savage
EDMONTON – Alberta's energy minister says the current spike in oil prices isn't enough reason to require the industry to spend more on cleaning up the tens of thousands of abandoned oil and gas wells in the province.
Sonya Savage says the province's recently adopted plan to fix the problem, which requires industry to spend $422 million next year and slightly more after that, is a fair and balanced approach.
She says it takes into account the industry's current troubles and its expected future growth.
Oil prices have spiked to $80 a barrel and are expected to climb higher.
Some industry analysts have said the profits those prices will generate should help fund the cleanup of nearly 100,000 abandoned wells in Alberta, a project that will cost tens of billions of dollars.
Experts like Sara Hastings-Simon at the University of Calgary's School of Public Policy say this may be Alberta's last chance to get the money from industry.
But Savage says current spending requirements will make a meaningful difference and could be increased two years down the road.
Tourmaline Increases Quarterly Dividend By 11%, Declares A $1.25/Share Special Dividend And Provides Operational Update
Oil down slightly on tight supply, limited Omicron impact
Canada's Trans Mountain oil pipeline returns to normal operating pressure
Surge Energy Inc. announces 2022 capital and operating budget; corporate update on shareholder returns business model; operations update


After a data component has been initialized, you need to populate it with data in any of the supported formats: JSON, XML, CSV, JSArray, HTML, Excel or HTMLtable.
There we have two major possibilities that are true for all the data components.
After data has been pushed to the component (loaded or parsed), it should be rendered within the component with the help of Webix templates.
1 . As a value of the component's url property. Data will be loaded right after initialization of the component. The type of incoming data should be specified (if it's not JSON) as well.
2 . As a parameter of the load() method that you apply to the component on the necessary event.
It can be called on the necessary page event (button clicking, etc.), as well as on an inner event of the component.
At the same time, you can set rather a complicated loading pattern in a proxy object that you should pass into the url property or the load() function.
Webix features predefined proxy objects. To learn more about proxy functionality, consult the dedicated article.
Furthermore, if a server-side dataset is too big, dynamic loading allows to load limited quantity of data items first and then load new data only as you scroll or page through the component.
Note that there's a separate article dedicated to Server-Side Integration. There you'll also find customization patterns for loading from a server.
With bound components, you can enable data loading not from the master component (as expected by default), but directly from the server.
Read more information on Data Binding.
to inform users that there's no data for this component.
More info on datatable loading screen support.
For other components, you can define Overlay Boxes and Progress Bar (Progress Icon) with the help of the dedicated modules.
onStoreLoad - fires when raw external data is fully loaded (regardless of data type).
In case something goes wrong with loading (and sometimes it does!), learn how to handle errors on the client side in the Processing loading errors article.
Here the data in supported formats comes as it is (string or array).
Firstly, it may be the value of the data parameter.
The variable may be declared either in the same file or in an external js-file you refer to in the document's head.
Secondly, data can be parsed with the help of the parse() method that takes the data and the datatype as parameters.
Since the event is triggered for the component DataStore, the handler should be prefixed by "data->".
Webix is integrated with the Promiz.js library to treat the result of asynchronous operations (like data loading) without callbacks.
It means that any Ajax request returns a promise object than can be treated with Promiz.js API.
The data will be parsed the moment it comes from the server.
Read more about Webix and Promiz.js integration.


It is the month-long challenge for people curious about plant-based food, which grew by 183% last year, thanks to a record-breaking 168,500 participants in the UK alone. And this year it's even more popular: on Sunday 30th December alone, one person signed up to the pledge every six seconds!
While not all of us are ready to give up eating meat and dairy completely, more and more of us are keen to experiment with cutting down for environmental, ethical or health reasons, leading to trends such as Meatless Mondays. Recent stats show that one in three of us regularly buy dairy-free milks, and it is claimed that one in five of us cook flexitarian (or semi-veggie) meals.
Being vegan is great for your health! According to the Academy of Nutrition and Dietetics, vegans are less likely to develop heart disease, cancer, diabetes, and high blood pressure than meat-eaters are. Vegans get all the nutrients that they need to be healthy, such as plant protein, fibre, and minerals, without all the nasty stuff in meat that may slow you down and make you sick, such as cholesterol and saturated animal fat.
Not only is being vegan good for us, it is good for the environment. Eating meat doesn't just hurt animals—it hurts people, too. It takes tons of crops and water to raise farmed animals. In fact, it takes up to 13 pounds of grain to produce just 1 pound of animal flesh! All that plant food could be used much more efficiently if people just ate it directly. The more people who go vegan, the better able we'll be to feed the hungry.
Making small changes to your everyday meals is one of the easiest ways to increase the amount of plant-based foods in your diet. You could start by removing meat or dairy one day a week and go from there. Or you could try changing one meal at a time, having vegan breakfasts during your first week, adding a vegan lunch during week two and so on. You could even try changing one product at a time by swapping cow's milk for almond or soya milk or butter for coconut oil or margarine. There's a plant-based alternative for almost every type of food you can think of, so you don't have to miss out on any of your favourite foods. For more inspiration, check out for recipes and inspiration online.


SFIB stress and failure of inclined boreholes software offers full 3D stress modeling for wellbore breakouts and tensile wall fractures. Forward modeling of inclined drilling-induced tensile wall fractures allows for assessment of the stress state around a wellbore. This also reveals tendency for compressive and tensile wellbore failure.
With SFIB software, you get down to uncommon and uncommonly profitable modeling detail. You can include thermal effects and account for rock strength anisotropy in weak bedding planes. Employ thermoporoelastic, poroelastic, and chemoporoelastic rock models for time-dependent effects on stability from mud-rock interactions.


text:
Overdue Books
Rem Koolhaas is the real diva
In the final installment of our summer series, Curbed's architecture critic re-reads all 1,344 pages of the Dutch architect's "S,M,L,XL"
By Alexandra Lange Aug 22, 2019, 12:12pm EDT
Illustrations by Naomi Elliott
Curbed's architecture critic Alexandra Lange takes a fresh look at classics of the architectural canon.
S,M,L,XL does not hide its ambition: 1,344 pages. Three inches thick. A dictionary, a chronology, a comic, an excerpt from Delirious New York, plans, diagrams, photographs, poetry, dialogues, history lessons and, last but not least, the work of Rem Koolhaas and his office since 1972. Three authors are listed on the cover of the book, which was published in 1995: OMA, Koolhaas specifically, and designer Bruce Mau. In recent years, editor Jennifer Sigler has also received her fair share of credit in press about the book.
In the first edition, the cover is silver with black and yellow embossed type. One name is in yellow, in lights: Rem.
The first two weighty books I re-read for this series wore their organization on their sleeves. Christopher Alexander worked in numbered patterns, starting with the largeness of the city and working his way down to the smallness of decor. Virginia McAlester organized her field guide chronologically, folk to colonial, Victorian to modern.
Ostensibly, this one is no different. The work of the Rotterdam-based Office for Metropolitan Architecture (OMA), Koolhaas's firm, is organized into, yes, small, medium, large, and extra-large categories. The texts are interspersed between visual sections. Dictionary entries, definitions drawn from hundreds of sources, run down the left side of the page beginning with Abolish, Absence, Accepted. The result is a jumble and a wave, a wash of information that doesn't actually hold you by the hand. We aren't wading in to the work of OMA, but taking the plunge. The first line of the introduction is "Architecture is a hazardous mixture of omnipotence and impotence," and already the audience is like, You aren't kidding with that!
I call you and me "the audience" because this book is really a performance. You can get what S,M,L,XL represents without reading a word. You can get it by reading all of the words and flipping by the pictures. You can open it at a random place and see what happens (I landed on a competition model for the Center for Media and Technology, Karlsruhe, 1989-'92). You can use it as a doorstop slash trophy.
I should know, because I have a first edition with yellow, rather than blue, type. I traded my editor for it when it showed up at the New York magazine offices in 1995, because I knew it was a trophy worth having, and reading.
My question, 24 years later, concerned the feat of endurance that warranted that trophy. To what audience is S,M,L,XL playing? Does it work? I wouldn't want all that labor to be for naught.
There is a person in here I actually like. An overtired, vulnerable young man who feels jerked around by jet lag, clients, culture, committees. He isn't saying, Fuck you for being interested in me, in the way Rem Koolhaas has been ever since the book's publication pushed him to starchitect level. Even at the book's launch event at the Architectural Association in London—his alma mater—Rem declined to charm. Here's the book, he says in so many words; must I explain?
You get the clearest sense of that appealing Young Rem in the haiku-containing essay "Learning Japanese," written in 1993. OMA was invited to participate in a Tokyo architecture exhibition; seven days later he is there, experiencing Japanese architecture culture for the first time.
Instead of obligations embedded in generic
free time, free time in Japan
is exceptional condition excavated from
general condition of obligation.
If you've been paying attention to recent reporting on the culture of overwork in Japan, you'll see that little has changed from the 1990s. But the Japanese are hardly alone. The sense of obligation Koolhaas describes is the obligation of the architecture school studio and the architecture office, a culture of overwork that drives people away from the profession.
The only way to succeed in that culture is to work like a cyborg. In S,M,L,XL Koolhaas quotes a memo from Toyo Ito, the dean of Japanese late-20th-century architecture, which compares Koolhaas to a "mechanical baseball pitching machine." "Only from a Japanese / such a compliment / would not be an / insult."
Unpaid internships, underpaid competitions, overtime, not to mention labor conditions on construction sites have all chipped away at the image of architecture as somehow more civilized, more artistic, and more fulfilling than other professions. The first point in the 10-point manifesto of The Architecture Lobby, an organizing group dedicated to improving working conditions in the profession, is "Enforce labor laws that prohibit unpaid internships, unpaid overtime; refuse unpaid competitions."
The first few pages of S,M,L,XL include charts showing the size of OMA's workforce, the firm's income and expenditures, employee turnover, employee travel. Project credits for the work inside are rendered as a two-column list, people and projects, with crisscrossing lines. Correct but illegible. It's easy to flip past most of these, as the graphics float over grainy and unfluffed photos of the office (piles of paper, leftover takeout). It is a statement, as the cover is a statement, as naming your firm Office for Metropolitan Architecture is a statement, that the work, like the book, is a collective project.
Data visualization would increasingly become part of the OMA project, a rhetorical device, as Shannon Mattern has written, used in tandem with words and more old-fashioned representations like models and drawings. For the public, sometimes uncomfortable with judging aesthetics, watching chunks of square footage assemble themselves into a stack connected by ramps, as at the Seattle Central Library, seemed like an architectural proof. Charts also become a way of representing architecture anonymously.
The failed attempts to present the firm's architecture as by OMA, and not by Koolhaas, continue. This is more the fault of the media than of individual architects, but from the outside, we can't tell how much the subject resists. Examine the recent coverage of the deeply average addition to the New Museum, to be designed by OMA New York. Ever since OMA set up a New York office, it has been presented as a duchy with a partner-in-charge responsible for the work. The first of these was Joshua Prince-Ramus, now of REX, who was the design lead for the Seattle Central Library and the Wyly Theater in Dallas. Today, it is Shohei Shigematsu. He's going to be the one designing the New Museum—or rather, he's going to be the leader of the team designing the New Museum from OMA's office in Manhattan—and yet, in the embargoed New York Times coverage, who must be quoted? Rem.
Look at the buildings we will remember OMA for, the Seattle Central Library, the CCTV Headquarters in Beijing, the bid to redesign the Museum of Modern Art that called it MoMA Inc. long before it became the chilly airport-size behemoth it is today—all competitions.
He may call competitions "a form of torture," but he is still playing the game. He's diagnosed the problem with architecture, but has he changed anything? Hard to say. I have no knowledge of OMA employees' hours, or the pay. (Most big-name architects, with the exception of Jeanne Gang, who once worked at OMA, have been silent on the question of pay inside their offices.) Meanwhile the articles in which Koolhaas rejects the word "starchitect" while being covered like a starchitect just keep coming.
In 2000, Index magazine asked Sigler to interview Koolhaas, turning to her because he was proving so difficult to pin down. Sigler, who was most recently the editor of the Harvard Design Magazine, asks Koolhaas if S,M,L,XL wasn't the end of his professional adolescence.
REM: I don't know of what, but it was definitely the end of something. You know the book was published at a moment of serious crisis in our office, so everything that happened since is part of the construction of a new office, the construction of a new way of looking at architecture that culminated in the founding of AMO. AMO doesn't stand for anything specific, but it could be Architecture Media Organization. OMA and AMO are like Siamese twins that were recently separated. We divide the entire field of architecture into two parts: one is actual building, mud, the huge effort of realizing a project; the other is virtual — everything related to concepts and "pure" architectural thinking. The separation enables us to liberate architectural thinking from architectural practice. That inevitably leads to a further questioning of the need for architecture, but now our manner of questioning has changed: first we did it through buildings; now we can do it through intellectual activities parallel to building.
JEN: You're continuing what you've always done, but now you're making it explicit.
Naming his firm Office for Metropolitan Architecture, including those laborious charts, creating AMO, these were all moves intended to take the heat off himself as a person and intended to get architects paid for all the things they do that aren't constructing buildings. S,M,L,XL was also one of those things, research made into a saleable product that wasn't supposed to serve as a sales brochure.
Ultimately, the book is a monument to and a polemic about labor. Its size represents the labor of designers, editors, printers, and packers, on top of the labor of the architects listed on that illegible project credit chart. The move Koolhaas made after its publication, to split OMA (the architects of buildings) from AMO (the architects of ideas), was a move to get paid for the free consulting work architects so often do as part of competitions, to be paid for writing and research, and to be paid for branding.
Mark Lamster wrote on Design Observer in 2010 that he would like to consign the "mania among design professionals for obscenely fat monographs" to history.
What catnip it was! The designer as a transformative thinker rather than merely a form-giver, a true hero for the global age! S,M,L,XL, inevitably, became a model. Who wouldn't want a big fat doorstop advertising their genius? Fat books feel good in the hand and they feed the ego.
The fat book, he wrote, is a lazy book, powered by images and lacking the scalpel of written argument. They are also wasteful of our time and resources as well as physically difficult to read.
Martin Filler, who remains the architecture critic at the New York Review of Books, reviewed S,M,L,XL for the New York Times in 1996. He called it "user-hostile." "Persistent readers may well experience the onset of carpal tunnel syndrome unless they use wrist supports," he wrote. And he calls the book's creators out for hypocrisy: "Countless architects have been the subjects of monographic catalogues deemed necessary as sales brochures to win clients." Here, the physical aspects of the book "do everything they can to divert attention from the fact that this volume is not much different in intent from, say, the collected works of Gwathmey Siegel & Associates."
S,M,L,XL is definitely and now defiantly an artifact of the pre-digital age, created by fax, paste-up, and print-out. Nowhere is this more obvious than in the photography. You may not realize how design websites have accustomed you to sharp photography, facade, interior, detail, project description until you try to make sense of the way projects are presented in this book. I squinted at every photo, waiting for it to achieve higher resolution. The idea is that projects are presented cinematically rather than as snapshots. In a traditional monograph—the selling kind—a spread should be all you need to "get" a project. The client needs to be seduced by clarity of form. But OMA's architecture wasn't like that (yet). Its built projects tended to be tucked in to existing city fabric, without clear forms and clear shots. Transparent walls, ramps, curtains, elevators were all showcases for movement, so, on the page, the eye had to move.
Whatever the rationale, that approach now feels dated. I am used to beautiful, well-lit images. I am used to absorbing architecture via a few well-chosen pictures on Instagram. Is it really so bad to understand something, if not everything, at a glance? The visual sections in S,M,L,XL can feel gloomy and tedious, like a Very Serious Documentary.
Koolhaas, Mau, and Sigler's great leap forward for the architecture monograph has been imitated, exceeded, and used for parts, primarily by the many American architects who once worked on Planet OMA. Koolhaas's disarming dialogues with clients (and with himself) turn up in WORKac's 2017 book We'll Get There When We Cross That Bridge, a "duograph" between principals Amale Andraos and Dan Wood.
Bjarke Ingels's archicomic Yes is More was foreshadowed by "Byzantium" in S,M,L,XL, illustrated by Tomas Koolhaas and Louis Price and chronicling a competition for a mixed-use development in Amsterdam that OMA completed in 1991. S,M,L,XL's visualizations have nothing on Studio Gang's first book, Reveal, which showcased the firm's research and diverse collaborators and had an equally complex chart of credits. Koolhaas's own studios, at Harvard's Graduate School of Design, have led to more big, multi-author books: The Harvard Design School Guide to Shopping, Lagos: How It Works, and collaborations like one with star graphic designers 2x4, which published its own giant monograph, It Is What It Is.
After he's done trashing the largeness of S,M,L,XL in the Times, Filler turned to the large scale of the work Koolhaas admires, underlining his affinity for Wallace K. Harrison, a midcentury architect also obsessed with bigness (see the Empire State Plaza in Albany) and willing to play ball with oligarchs and developers.
Although at times [Koolhaas] plays the existential romantic, dramatizing the harsh realities of big-city life, he also knows how to translate his fantasies into workable solutions. He is a shrewd political player and self-promoter whose understanding of how public architecture gets assigned and built is not the least of his noteworthy talents.
For too long architects had done that work as adjacent to the highest glory, building a building, essentially donating analysis to potential future clients. Koolhaas wants to be the architect and the client, torching the historical lines between art and commerce, the gentleman designer and the businessman developer.
That's why he admires John Portman so much. The Atlanta-based architect and developer, who died in 2017, never pretended to play the mother's house-museum competition-concert hall-skyscraper game. He skipped right to bigness, creating the interior atriums (and the hotels, office buildings, and shopping malls around them) that transformed American cities, particularly in hot climates, during the 1970s. In the essay "Atlanta," filed under XL, Koolhaas writes:
John Portman is a hybrid; he is architect and developer, two roles in one. That explains his tremendous power: this combination makes him a myth. It means, theoretically, that every idea he has can be realized, that he can make money with his architecture, and that the roles of architect and developer can forever fuel each other. In the early '70s, to a power-starved profession, this synthesis seemed revolutionary, like a self-administered Faustian bargain.
While American architecture's intellectual heroes were making works on and of paper—Peter Eisenman's endless iterations, Lebbeus Woods's endless drawings, John Hejduk's endless models—Portman was building "without opposition, without influence, without inhibition."
This is when Young Rem, at that time a screenwriter, writes Delirious New York about his travels in America. That book, like this one, is filled with appreciation for theme parks, commercial architecture, and architects who know how to pitch and when to compromise. His dream practitioner bends committees to his will, takes over sections of cities, makes it happen. Harrison, father of Lincoln Center; Victor Gruen, father of the shopping mall; John Portman, father of the atrium: These are not architecture-school heroes but financial ones.
Which is why I wasn't entirely surprised to find, on page 1008, a thoroughly researched historical essay on the creation of Singapore, the island city-state which continues to be a repository for ambitious megastructural projects, from airports to botanical gardens, and whose citizens' high standard of living is undergirded by an authoritarian government. This is why it pays to page through the whole bloody book: On my other trips through it, I never noticed this essay. Koolhaas calls Singapore "a pertinent can-do world" and refers to its leaders' "ruthless determination to avoid the debris and chaos that democracy leaves in its wake elsewhere." "Singapore is clearly not free," he writes, "but at the same time it is difficult to identify what precisely is unfree."
As in his description of Portman's architecture and its effect on the city, Koolhaas is enthralled. Not laudatory, but fascinated.
After touching all 1,344 pages, this is how I feel about Koolhaas too. The headline on this piece is a commentary on constant sexist coverage of the woman who was, for a time, Koolhaas's rival globe-trotting architecture star, the late Zaha Hadid. Her imperiousness, her clothes, her distance made her in media terms slightly monstrous, while for him the interviews in cars speeding between European capitals, the Prada wardrobe, the endless faxes begging for his attention became part of his chilly allure.
No matter how much Koolhaas tries to share the spotlight, it won't stick. It isn't clear to me if it is us (the architectural audience, the media) or him who ruthlessly drags the focus back to the tall, skinny man behind the curtain designed by longtime collaborator Petra Blaisse.
Could he have used his stardom to refuse competitions, establish parameters for equitable practice, set a 40-hour workweek, not work in China and the Middle East? Maybe. Did he? No.
S,M,L,XL lays out the reasons why one could try to overthrow the architectural system, but perhaps the book's very popularity redirected energy away from revolution and toward the success that Koolhaas had, before 1995, found so elusive. (Maybe he never wanted a revolution for everyone else, anyway.) In the ambiguity of his diva-tude I can admire the prescience of his analysis and believe today's revolutionaries should keep their manifestos short and sweet.
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Wood & Hay Funeral Directors :: Burial or cremation?
When arranging a burial, a choice must be made as to which cemetery to use.
In East Lothian and Midlothian ground can sometimes be purchased prior to a death. This situation is different in Edinburgh, where ground can only be purchased at the time of a death.
For information on the cost of purchasing ground and the cost of an interment, visit our burial costs page.
When arranging a cremation, a choice must be made as to which crematorium to use. In Edinburgh there are three crematoria. Mortonhall Crematorium is on the south side of the city, and is owned by Edinburgh City Council. Warriston Crematorium is on the north east side of the city and is privately owned by Edinburgh Crematorium Limited. Seafield Crematorium is on the east side of the city, and is also owned by Edinburgh Crematorium Limited.
Mortonhall Crematorium is situated on Howdenhall Road close to the Edinburgh city bypass, and easily accessible from the south and west of the city. Mortonhall has two chapels, the Pentland Chapel and the Main Chapel. The Pentland Chapel can seat about 60 people and the Main chapel can seat 200 or more people. Both chapels have an organ, and neither have steps into the chapel, which makes them easily accessible for wheelchairs.
The times in the Pentland chapel are every hour with the first time being 9.30 am and the last time 4.30 pm Monday to Thursday, 9.30 until 3.30 on a Friday, and 9.30 am until 11.30 am on a Saturday. The times in the Main chapel are every hour on the hour with the first service at 9 am and the last 4 pm Monday to Thursday, 9 am until 3 pm on a Friday and 9 am until 11 am on a Saturday.
Warriston Crematorium is situated on Warriston Road just off Ferry Road. Like Mortonhall, Warristion has two chapels, the Cloister Chapel and the Lorimer Chapel. The Cloister Chapel can seat about 60 people and the Lorimer chapel can seat around 200 people. Both chapels have an organ, and are accessible for wheelchairs.
The times in the Cloister chapel are every 40 minutes with the first time being 9.10 am and the last time 4.30 pm Monday to Friday, and 9.10 am until 12.30 pm on a Saturday. The times in the Lorimer chapel are every hour on the hour with the first service at 9 am and the last 4 pm Monday to Friday, 9 am until 12 pm on a Saturday.
Seafield Crematorium is situated on Seafield Road in the east of the city. Seafield has one chapel which will seat about 150 people. The chapel is accessible for wheelchairs.
The times in the chapel are on the hour, every hour with the first time being 9 am and the last time being 4 pm Monday to Friday, and 12 pm on a Saturday.
It must be noted that in the Cloister chapel and the Pentland chapel, the 40 minute intervals are between services, not the length of the service. The service in these chapels should last about 20 minutes, allowing time to arrive and be seated, and time to leave the chapel, and the chapel area. Similarly in the Lorimer chapel, the Main chapel at Mortonhall, and the chapel at Seafield, the time interval is one hour. The service in these chapels lasts about 25 minutes, allowing time to enter the chapel and be seated, and time to leave the chapel and meet people after the service. It is possble to book two times if required at additional cost.
For information on the cost of each chapel and each crematorium, visit our cremation costs page.


text:
Fort Louis was a Royal fort built just outside the walls of the Huguenot city in La Rochelle.

The fort was a source of great tension between the Huguenots of La Rochelle and Louis XIII, and was perceived as a real threat to their survival. Marshal Lesdiguieres predicted "Either La Rochelle must take Fort Louis, or the Fort will destroy La Rochelle."

The construction of the fort had been started by the Count of Soissons in 1620 during the first Huguenot rebellion. With the Treaty of Montpellier, Louis XIII had agreed to remove the fort in due time, but he and his Minister Richelieu later temporised and avoided the promised removals despite the requests by La Rochelle.

Fort Louis played a key role in establishing the fortifications around La Rochelle during the 1627-1628 Siege of La Rochelle.

Notes

Châteaux in Charente-Maritime
Buildings and structures in La Rochelle


"Agency problems" are what economists call situations where a person's interests diverge from his or her firm's interests.
Large companies are in a constant state of agency crisis. A primary role of senior management is to counter agency problems through organizational structures and incentive systems. For example, most big companies divide themselves into de facto smaller companies by creating business units with their own P&L or similar metric upon which they are judged. (Apple is a striking counterexample: I once pitched Apple on a technology that could increase the number of iTunes downloads. I was told "nobody optimizes that. The only number we optimize here is P&L in the CFO's office").
If you are selling technology to large companies, you need to understand the incentives of the decision makers. As you go higher in the organization, the incentives are more aligned with the firm's incentives. But knowledge and authority over operations often reside at lower levels. Deciding what level to target involves nuanced trade offs. Good sales people understand how to navigate these trade offs and shepherd a sale. The complexity and counter-intuitiveness of this task is why it's so difficult for inexperienced entrepreneurs to sell to large companies.
Agency problems also exist in startups, although they tend to be far less dramatic than at big companies. Simply having fewer people means everyone is, as they say in programming, "closer to the metal". The emphasis on equity compensation also helps. But there are still issues. Some CEOs are more interested in saying they are CEOs at parties than in the day-to-day grind of building a successful company. Some designers are focused on building their portfolio. Some developers are only interested in intellectually stimulating projects. Every job has its own siren song.
One of the reasons The Wire is such a great TV show is that it shows in realistic and persuasive detail how agency problems in large organizations consistently thwart well intentioned individual efforts. The depressing conclusion is that our major civic institutions are doomed to fail. Those of us who are technology optimists counter that the internet allows new networks to be created that eliminate the need for large organizations and their accompanying agency problems. Ideally, those networks recreate the power of large organizations but operate in concert like startups.


text:
Het seizoen 1952/53 was de 36e editie van de Belgische Tweede Klasse. De competitie ging van start in de zomer van 1952 en eindigde in het voorjaar 1953. Het was het eerste seizoen na de competitiehervorming van 1952, waarbij het aantal nationale nationale niveaus van drie op vier werd gebracht. Een gevolg hiervan was dat het tweede nationale niveau, dat tot 1952 bestond uit twee reeksen van 16 ploegen die Eerste Afdeling werden genoemd, voortaan uit één reeks van 16 ploegen zou bestaan, die Tweede Klasse werd genoemd.

Lyra won deze eerste editie van de vernieuwe Tweede Klasse en promoveerde samen met vice-kampioen en stadgenoot Lierse SK naar de Eerste Klasse.

Gedegradeerde teams
Deze teams waren gedegradeerd uit de Ere-afdeling voor de start van het seizoen:
 R. Racing Club de Bruxelles degradeerde na 7 seizoenen terug naar 2e nationale.
 RUS Tournaisienne degradeerde na 7 seizoenen terug naar 2e nationale.

Gepromoveerde teams
Als gevolg van de competitiehervorming waren er geen gepromoveerde teams uit Promotie. De hoogst geëindigde teams uit promotie vormden samen samen met de degradanten uit Eerste afdeling de vernieuwde Derde Klasse.

Ploegen
Deze ploegen speelden in het seizoen 1950-51 in Eerste Afdeling reeks A. De nummers komen overeen met de plaats in de eindrangschikking:

Eindstand

P: wedstrijden gespeeld, W: wedstrijden gewonnen, G: gelijke spelen, V: wedstrijden verloren, +: gescoorde doelpunten, -: doelpunten tegen, DS: doelsaldo, Ptn: totaal punten K: kampioen en promotie, P: promotie, D: degradatie

Promoverende teams
Deze teams promoveerden naar Eerste Klasse 1953-54 op het eind van het seizoen:
 K. Lyra (kampioen) promoveerde na 3 seizoenen terug naar eerste klasse.
 K. Lierse SK (vice-kampioen) promoveerde na 5 seizoenen terug naar eerste klasse.

Degraderende teams
Deze teams degradeerden op het eind van het seizoen naar Derde Klasse 1953-54:
 RFC Renaisien (voorlaatste) degradeerde na 19 seizoenen in 2e klasse
 R. Stade Louvaniste (laatste)  degradeerde na 14 seizoenen in 1e en 2e klasse.

Topschutter
Jozef Piedfort - K. Lyra - 27 doelpunten

Referenties

Tweede klasse voetbal België
Belgie 2


Mayan Princess One bedroom condo on the second floor. A view of the pool and gulf view.King Bed in Master Bedroom. Bunk Beds built into the living room. 20 inch TV in Master Bedroom. 22 inch TV in Living Room. DVD Player. This unit will comfortably sleep 2 adults and 2 children.
1 Bedroom Unit, 1 bathroom, Maximum Occupancy of 4 - Maximum occupancy limits are enforced.
We had stayed at other condos in the area, and this one is our current favorite. Location: perfect, room: nice, property: attractive and clean. My only complaints: 1) The Jacuzzi-style tub/shower was NOT friendly. Difficult to get in/out, even for the able-bodied. Would have been impossible if we had chosen to take our elderly parents. Next time we will pick a unit with a regular shower. 2) Door to condo was super difficult to lock/unlock; had to go to the front desk for help. Other than that, nice property, clean, friendly, etc. We like that it's not in the town so less traffic and beach less crowded.
We were at the Mayan Princess the week before Memorial Day and had a great time. Not crowded since it was between spring break and Memorial Day. We really enjoyed the short walk on the boardwalk to the beach where we played in the water for most of our time there. On the last night, we decided we needed to try the pools out before we had to leave. Three beautiful pools of varying depths were clean and beautiful.
It was a nice location and room was clean, it was a great stay. Only thing to suggest is perhaps it needs to be updated a bit.
The property location is nicely located outside of town away from the crowds. Family friendly. My children very much enjoyed the heated pool. The room was ok. Could use some updates and maintenance. Overall we had a great time. Will definitely be back.


And rend all nature's frame.
-Isaac Watts, Hymns and Spiritual Songs, 1707-1709.
What are your goals as an artist and hymn writer?
What is the role of the artist in the church?
What is the most important aspect of a hymn?
"Throughout Scripture when you see God's people singing, they sing to God, and they sing together. At a pragmatic level, we need to write songs that are rich in vibrant truth, and write songs in which every musician accompanies the artist who called the congregation to worship. Every piece of artistry a worship leader has is given to lead the congregation in singing.
"My wife, Kristyn, and I recently returned from a tour where we had the privilege of sharing our music in cities across North America. As we do on our tours, we partnered with most of our concert sponsors to host a lunch and time of discussion with local pastors, worship leaders, and other church musicians.
Whose sins are covered in the sight of heaven.
Not count all his iniquity and guilt.
Whose spirit harbors no deceitfulness.
I pined away through my incessant groaning.
My strength was sapped as by the summer's heat.
I then at last acknowledged my transgression.
And all my guilt Thou hast forgiven me.
Thou me with great rejoicing dost surround.
And in the way that you should go will guide you.
And, keeping watch, I will with you abide.
They disobey unless restrained by force.
Him will the LORD with steadfast love surround.
Those who revere Him are with mercy crowned.
For light and life He will to you impart.
Now shout for joy, you men of upright heart.