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Enzyme engineering for rare genetic diseases and cancer
Aeglea BioTherapeutics is engineering human enzymes for the treatment of both rare genetic diseases and cancer.
Aeglea Biotherapeutics
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Amino acids (AAs) are fundamental building blocks of life, making up proteins, cycling nitrogen, providing energy and transmitting signals. Nine of the 21 AAs found in proteins are 'essential', meaning they must come from dietary sources. Four other AAs, including arginine and cysteine, are 'semi-essential', meaning there are biosynthetic pathways to produce them in humans, but a dietary source is required in some circumstances. Although adequate supplies of these AAs are clearly necessary for health, an oversupply of some AAs can, perhaps surprisingly, be devastating and even fatal.
Aeglea BioTherapeutics is a leader in the creation and development of novel human enzymes that act in the circulation to degrade specific AAs. Aeglea's engineered proteins are designed as enzyme-replacement therapies for the treatment of rare genetic diseases, removing excess AAs that would otherwise accumulate to toxic levels. These enzymes also hold promise as therapies for certain cancers that have become dependent on AAs to fuel their growth. The depletion of key AAs in blood may selectively starve tumor cells, targeting a tumor growth pathway that otherwise can't be blocked by antibodies or small-molecule therapeutics.
Aeglea is focused on discovering and developing treatments for abnormalities in AA metabolism for which the biology is well understood and there is a compelling unmet medical need. Rare genetic diseases are a large collection of over 700 disorders, including in AA metabolism. These rare metabolic diseases currently have limited treatment options, and no single therapy is appropriate to treat the full range of diseases. Aeglea concentrates its efforts on treatments that are amenable to a blood-based mechanism of action. According to Aeglea's CEO, David G. Lowe, this focus offers a high probability of success in creating effective treatments that will have a substantial impact on the course of disease. Serum AA levels are an accessible and clinically meaningful pharmacodynamic measure that provides proof of mechanism and serves as a potential surrogate marker for clinical benefit. Clinical and preclinical testing of several engineered human enzymes has shown reduced AA levels in blood after treatment.
All cells require a balance of AAs for normal function, but tumor cells can become particularly dependent on specific AAs. The energetic cost of AA production is high. In some cases, tumor cells can gain a growth advantage during oncogenesis by suppressing certain biosynthetic pathways, such as synthesis of the semi-essential AA arginine. While it creates a growth advantage for the tumor, the loss of this pathway also provides Aeglea with a potential biomarker or companion-diagnostic strategy to identify arginine-dependent tumors that are vulnerable to a reduction in arginine. Two US Food and Drug Administration– approved microbial enzymes that target asparagine conceptually validate AA targeting in cancer treatment, although immunogenicity appears to be a limiting factor for this approach. Although it is generally thought that the human genome cannot provide direct product candidates enabling broader exploitation of tumor dependence on AAs, Aeglea believes that its product candidate AEB1102, an engineered human arginase enzyme, has the potential to reduce blood arginine levels and to be less immunogenic than microbe-derived enzymes.
AEB1102, Aeglea's first product candidate to enter the clinic, has been shown to reduce blood arginine levels in clinical studies, thus providing proof of mechanism. Aeglea has an open phase 1/2 trial in the United States for patients with impaired arginine degradation caused by a mutation in the arginase 1 gene (ARG1) (Fig. 1). ARG1 deficiency is a devastating, life-threatening urea-cycle disorder that presents in early childhood. Affected children develop neurologic symptoms, such as spasticity, seizures and neurocognitive deficits that may ultimately lead to severe intellectual disability. To date, no therapy has been approved that addresses the fundamental defect underlying the disease. To Aeglea's knowledge, AEB1102 is the first attempt to create a potential enzyme-replacement therapy for ARG1 deficiency. The hope is that it may dramatically alter patients' lives if treatment is begun early in life, thereby delaying or even preventing progressive neurological and neurocognitive impairment.
Figure 1: Aeglea's product pipeline.
AEB1102 is also currently in phase 1 trials in cancer patients with advanced solid tumors and with hematological malignancies. Biomarkers of tumor dependence on arginine have shown value as predictors of sensitivity to arginine depletion—for example, in patient-derived xenograft models with a direct cell-killing effect—and will help guide the selection of future cancer indications to pursue in later clinical trials with AEB1102.
This work has focused Aeglea's attention on a select number of tumors predicted to be arginine-dependent, such as small-cell lung cancer, cutaneous melanoma, uveal melanoma, Merkel cell carcinoma, acute myeloid leukemia and myelodysplastic syndromes. Furthermore, contrary to expectation, arginine depletion is not broadly immunosuppressive. In preclinical studies, Aeglea has found additive or synergistic activity of arginine depletion with AEB1102 in combination with immune-checkpoint inhibitors, opening the possibility of combination trials.
In addition to the ongoing trials with AEB1102, Aeglea has a robust pipeline of engineered human enzymes that target other key AAs (Fig. 1). These product candidates degrade cysteine and its oxidized form, cystine, to target tumor dependence on glutathione for protection against oxidative stress, as well as methionine, an essential AA for which some cancers have an increased appetite. A third enzyme, AEB4104, degrades homocystine, which accumulates in people with the rare genetic disease classical homocystinuria as a result of a deficiency of the enzyme cystathionine β-synthase. Aeglea is committed to creating value by pursuing multiple clinical pathways in parallel, each focused on diseases with the potential to be markedly affected by a single enzyme.
David G. Lowe, CEO
Austin, Texas, USA
Email: investors@aegleabio.com
Website: www.aegleabio.com
Read our June 2017 issue.
Redefining cancer therapy with photoimmunotherapy
Aeglea BioTherapeutics was founded in December 2013 to develop engineered human enzymes invented in the laboratory of George Georgiou, Ph.D. of The University of Texas at Austin. The convergence of discovery and technology has created a significant opportunity for Aeglea to potentially impact both the treatment of inborn errors of metabolism and cancer.


Focusing on roleplaying games as well as board, card and strategy games, Tracon Hitpoint is the spinoff convention of Tracon, held for the second time ever in March 2017, from Saturday the 3rd to Sunday to 4th. This year Tracon Hitpoint – like its parent convention – will be held at the spacious Tampere Hall.
There will be opportunities for international guests to participate in English-language game sessions, as well as meet other English-speaking convention-goers. Most of the programs are in Finnish, but possible English programs will be marked as such in the program schedule, to be published before the event.
Ticket sales will open starting from Monday the 31st, October 2016. If you have a Finnish bank account, tickets can be bought from Tracon's web store. You can also purchase a ticket with cash at the event, provided that the event does not sell out beforehand.
Tracon Hitpoint (2017) -tapahtuman järjestää Tracon ry. Sivustoa pyörittää TraContent CMS Enterprise Edition © 2014–2018 Santtu Pajukanta.


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Q: How to send a audio file to a view using ASP.NET MVC I have a .mp3 file in my content folder on the server side. How can I return it to a view (client side) as a action result?

A:     public ActionResult Play()
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                }
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            catch (Exception e)
            {
                if (e.Source != null)
                    Console.WriteLine(e.Source);
                throw;
            }
        }

        return new EmptyResult();
    }

redpajama_set_name: RedPajamaStackExchange


With over 25 years experience in supplying wholesale vending machines and supplies, here at Eurocup we've built a strong reputation for providing excellent service and products.
We work to ISO 9001 and BRC (British Retail consortium) standards, packing the largest range of incup drinks in the market, and have been licenced to pack Nestle products for over 30 years.
We offer an extensive range of products, from small table-top machines through to high-capacity systems, as well as many dozens of different drink and snack options.
If you require vending machines or vending machine supplies on a wholesale basis, simply use our contact form or call 0800 220 208.


The Verge launched its new Verge Science vertical on Wednesday and tapped Wired reporter Katie Drummond as editor, the publication said.
Drummond most recently covered military research on Wired's defense blog, Danger Room, and previously worked at Rupert Murdoch's failed tablet news app The Daily and for AOL News, where she reported on science and health news.
The new section marks further expansion of the nascent Vox Media-owned tech and culture site that has made a name for itself as a journalist's news startup, slamming the Huffington Post for scraping 239 words of an aggregated story and touting its thorough, original reporting.
In October, Vox launched Polygon, a videogame news site to rival competitors like Joystiq, Kotaku and IGN.
"We'll deliver rigorous, thoughtful, authoritative reporting on what's new, what's coming next, and why it actually matters — and we'll make room for both certifiable science geeks and casual readers to find out what inspires them," Drummond said in a statement.
Keeping with that promise, the section debuted with an investigation into the potential risks of federal research designed to prevent a pandemic, and a Q&A with best-selling science journalist Mary Roach.
Watch Drummond introduce the section in a video here.


Although I've trained as a two dimensional designer, I've always been drawn to making three dimensional things, forming shapes and solving problems in 3D space. I love the elemental physicality of working with silver. There's something about forming and joining metal that can make you feel connected to artisans from millennia ago.
For me, making every piece by hand is essential to keeping that connection between the artist and the person who wears it. Retaining maker's marks in the finished jewellery helps to give each piece a voice and personality. I like working with simple and sometimes quirky forms and letting them have their way with me.
You can follow me on Instagram: @silverformstudio.


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Wwww » Encyclopedia » Index » Surface_Waves_on_Liquid_Film_Flow
Surface Waves on Liquid Film Flow
As will become evident in later chapters, condensation or evaporation at the interface of a thin liquid film flowing over a solid surface is often encountered in engineering applications. This type of process is commonly found in chemical and mechanical engineering equipment such as condensers, long-tube evaporators, wetted wall columns, and cooling towers. The fact that current literature shows continued interest in this general area affirms its continued importance. The problem of the transport from a liquid layer running down a vertical wall has been considered in literature with particular attention to heating, evaporation, condensation, and gas absorption for various applications. The flow in such a liquid layer may be either (a) laminar with a constant thickness, or (b) laminar with variable thickness due to waves, or turbulent with waves moving down the interface. Kapitza (1964) predicted theoretically that the mean film thickness is reduced by approximately 8% due to ripples on the interface. Many experiments have focused on determining the values of the wave properties in both laminar and turbulent flows. Experimental data on the mean film thickness of wavy laminar flow falls between the predictions of Kapitza and Nusselt (smooth interface) theories. Although the wave effect does not have any significant effect on the mean film thickness in wavy laminar regions, it plays a major role in heat and mass transfer processes. The structure of the liquid film running down a plane usually shows a randomly distributed wave on the surface, except at low flow rate at the entry region, where a periodic motion exists. Figure 1, which is taken originally from Rogovan et al. (1969) shows such a variation as obtained at a Reynolds number of 54 for water.
Comparisons of the experimental and theoretical values of the transport in falling film should be supported by a specification of the nature of the waves, for it is through the interaction of the normal velocities produced by the waves and the distribution of the transported quantity that the additional transport arises. But this is complicated by the existence of an initial wave-free length, depending upon the way in which the film was formed by the liquid supply, and by a region of wave development that ostensibly culminates in a steady regime at a distance far enough down the height of the film. Brauer (1956), for example, made measurements on water, and mixtures of water and diethylene glycol, at a distance of 1.3 m from the point of film initiation, and found sinusoidal waves to begin at a Reynolds number, where Ka = ν4ρ3g / σ3 is the Kapitza number. The ratio of the crest height of the waves to the mean film thickness increased with the Reynolds number to about twice for this Reynolds number than for higher Reynolds number. This ratio remained the same up to a Reynolds number of 140 / Ka1 / 10. Between these Reynolds numbers the waves become distorted and no longer sinusoidal; above the higher Reynolds number there were secondary capillary waves on the surface. Throughout, up to 4Γ / μ = 1600, the average film thickness remains essentially that given by the Nusselt analysis. But in the range where the ratio of the crest height to the mean film thickness is almost constant, the wave frequency increases with the Reynolds number to indicate a basis for a proportional increase in heat and mass transfer.
Koizumi et al. (2005) studied the behavior of a liquid film flowing down the inner surface of a pipe with countercurrent gas flow. In the experiment, the gas used was air, and silicone oils of 500, 1000, and 3000 cSt as well as water, were used for the liquid phase.
Three primary parameters were correlated: the film thickness, wave velocity, and wavelength. The film thickness was given three different values: minimum, maximum and mean film thickness. The film height was determined by taking photos of the film and measuring its thickness. The wave velocity was determined by seeing how far a wave peak traveled during the time interval between picture frames. The wavelength was determined in a similar manner; that is, photographs were taken, and the distance between peaks of the wave were measured.
Figure 1 Change in the local liquid film thickness at Re=54 at a distance from a sprayer of (a) 130, (b) 310, (c) 445, and (d) 670 mm (Faghri and Payvar, 1979).
Figure 2 presents experimental results for water and silicone oil with no airflow for dimensionless δ * versus the Reynolds number, where , δ is the film thickness, τw is the wall shear stress and is the liquid density. When there is no airflow, the maximum film thickness of the 500 cSt and the 1000 cSt silicone and water films is much greater.
Figure 2 Dimensionless liquid film thickness as a function of Reynolds number for falling liquid film (adopted from Koizumi et al., 2005).
To correlate the wave properties using a non-dimensional analysis, the non-dimensional wave velocity, and maximum film thickness, , are found according to the Buckingham pi theorem. They are functions of the Reynolds number ( ), the Morton number ( KF = ρ3ν4g / σ3) and the nondimensional wavelength ( ), where ww is the wave velocity and λ is the wavelength. Nosoko et al. (1996) developed the following correlations for wave velocity and maximum film thickness:
Equations (1) and (2) require information about the wavelength; therefore, the correlations are not closed. The wave velocity and maximum film thickness should be evaluated only from the film flow rate and physical dimensions, if possible. The wavelength correlation was incorporated into the Nosoko correlations by Koizumi et al. (2005), and the constants and exponents were modified for better accuracy. The final forms are
where and is the mean film thickness.
The thickness of these liquid films is small enough that boundary layer assumptions are valid. However, these films are not thin enough for disjoining pressure to play any significant role. Figure 3 shows a slow liquid flow on an inclined surface with negligible shear stress at the free surface. The gravitational and liquid viscous forces, as well as surface tension effects, are dominant. As the mass flow rate of the liquid increases, waves on the liquid film interface can be observed, as indicated by Fig. 3. The flow regimes of the liquid film include smooth laminar, wavy laminar, and turbulent, which correspond to different film Reynolds numbers. The Reynolds number is defined as
where Γ is the mass flow rate per unit width and is the mean velocity of the liquid film. The liquid film is laminar if the film Reynolds number is below 30. A wavy flow regime can be observed when the film Reynolds number is between 30 and 1600. The liquid flow becomes turbulent when the film Reynolds number is above 1600. For a fully-developed steady-state downward laminar flow, the momentum equation reads
Figure 3 Liquid film on an inclined surface.
Integrating eq. (7) twice and considering the boundary conditions w = 0 at y = 0 and dw / dy = 0 at y = δ, the velocity distribution in the liquid film is obtained.
The mean velocity in the liquid film is then
which is obtained under assumption that the liquid flow is steady-state. Under these assumptions (Nusselt analysis) and assuming , the dimensionless film thickness, and film velocity at the surface δ, wδ and the mean velocity are given for below:
When waves are present, the liquid film flow will be unsteady. However, it is assumed that eq. (9) is also valid for unsteady film flow. Consideration of hydrostatics and the Young-Laplace equation at the interface yields:
Since there is no motion in the vapor phase, the pressure gradient in the vapor phase satisfies
The momentum equation for an unsteady-state flow in the liquid film is
Substituting eqs. (13) – (14) into eq. (15), the momentum equation becomes
(16) Integrating eq. (16) and considering the continuity equation, two governing equations for δ(z,t) can be obtained:
These equations can be solved along with the energy equation. Our purpose, however, is to find the conditions of stability of the film. Assuming that δ = δ0 + δ' Z and , and noticing from eq. (9) that
the following is obtained:
The fluctuating component δ' is assumed to be a sinusoidal wave of the form
where α is the wave number and c is the wave velocity. For α > 0, which is the condition under which waves exist, it follows from eqs. (20) and (21) that
which can also be written in terms of film Reynolds number, , i.e.,
Equation (22) indicates that the critical Reynolds number at which waves appear equals cotθ. For a vertical surface where
become , which means that waves can be present no matter how small the film Reynolds number is. This result contradicts experimental observation, because waves are present only when the film Reynolds number reaches a certain value. This contradiction can be solved by considering the amplification rate of wave amplitude. If amplification over the time interval required to travel 100 times the liquid film thickness is considered, the amplification factor is (Benjamin, 1957; Carey, 1992)
For saturated water at one atmosphere, σ = 0.0589N/m, and and eq. (24) becomes
The dependence of disturbance amplification versus film Reynolds number is shown in the following table:
It can be seen from the above table that the wave becomes significant after is greater than 40. Waves increase the heat transfer coefficient during evaporation (also condensation) of wavy films as compared to a smooth surface due to an increase in interfacial surface area and mixing action (Faghri and Seban, 1985). Heat transfer during condensation and vaporization over a wavy liquid film will be discussed in detail in Chapter 8 and 9, respectively.
Benjamin, T.B., 1957, "Wave Formation in a Laminar Flow Down an Inclined Plane," Journal of Fluid Mechanics, Vol. 16, pp. 554-574.
Brauer, H., 1956, "Stromung and Warmenbergang bei Rieselfilmen," VDI Forschunsheft, Vol. 457, Dusseldorf.
Faghri, A., and Seban, R.A., 1985, "Heat Transfer in Wavy Liquid Films," International Journal of Heat and Mass Transfer, Vol. 28, pp. 506-508.
Kapitza, P.L., 1964, "Wave Flow of Thin Layers of a Viscous Fluid," Collected Papers of P.L. Kapitza, MacMillan, NY.
Nosoko, T., Yoshimura, P.N., Nagata, T., and Oyakawa, K., 1996, "Characteristics of Two-Dimensional Waves on a Falling Film," Chemical Engineering Science, Vol. 51, pp. 725-732.
Rogovan, I.A., Olevskii, V.M., and Runova, N.G., 1969, "Measurement of the Parameters of Film Type Wavy Flow on a Vertical Plate," Theoretical Foundations of Chemical Engineering, Vol. 3, pp. 164-171.
Retrieved from "http://wwww.thermalfluidscentral.org/encyclopedia/index.php/Surface_Waves_on_Liquid_Film_Flow"

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'Always Be My Maybe' Review: The Sweet Story of Childhood Love Being Reunited DONE
by Shea Vassar
Ali Wong first impressed audiences with her outrageous and raunchy Netflix standup special Baby Cobra — performed with confidence while the comedian was eight-months pregnant — she later recaptured the concept with her second pregnancy. Her new appearance, another Netflix debut, is in the romantic comedy Always Be My Maybe, where a new, less-raunchy side of Ali Wong is displayed.
Wong plays a young girl in San Francisco, Sasha Tran, whose parent's constant absence while they run a local shop pushes her to spend time with the family next door, the Kims. Sasha spends her time with Mrs. Kim as they prepare traditional dishes and runs around the local spots with Marcus Kim, played as an adult by Randall Park. Years later, after Mrs. Kim dies, the emotional Sasha and Marcus have an intimate moment in the backseat of his Corolla. They attempt to act like the dynamic hasn't changed, but after a blow-up of emotions at the local Burger King, it becomes apparent these two best friends can no longer act the same.
Fast forward to 2019, sixteen years after the infamous Corolla and Burger King incidents. Sasha has moved to Los Angeles and jumped to fame as a celebrity chef, but Marcus has remained at home, stuck in a similar time, place, and teenage bedroom as before while still playing in the same local band. When the two are reunited, the history of romantic feelings collides with the reality that their lifestyles are completely different.
The infamous Burger King scene in Always Be My Maybe © Netflix
I expected a writing collaboration with Park and Wong, both who have incredibly impressive resumes in the comedic field, to be an experience of possibly-pee-your-pants laughter every few minutes. However, going in with this mindset only puts the plot of the movie in a tiny box. The writing of the plot is okay, but the actual development and complexity of the characters are where the duo's ability behind the scenes stands out. Thankfully, this is more about the characters than the typical romantic comedy cliches that the film depends on moving forward with.
The lack of exuberant comedy Wong is known for doesn't hurt Always Be Your Maybe, as it shows that she is versatile enough to lead in a feature film. Comedy isn't erased because there is just enough relief for the heavyweight of serious topics that the characters go through. Plus, the funny moments between characters feel much more natural than if the film had decided to try and keep up with the comedy in Wong's standup specials. The mix of realistic humor, real-life situations, and an original conflict standing between the lovers make for a very charming story. It doesn't hurt that the two leads are also talented in their comedic timing due to their impressive resume.
The writers aren't the only two that should be credited with making a character-driven, feel-good movie. Director Nahnatchka Khan, best known for creating the sitcom Fresh Off the Boat, uses her ability to create realistic relationship moments similar to those seen on primetime television and mixes them with the tried and true tactics of the 'rom-com' genre. Always Be My Maybe feels a little like When Harry Met Sally but with less Kat's Deli sandwiches and a lot more crystallized lavender air bubbles and no main white characters.
Ali Wong with Randall Park in Always Be My Maybe © Netflix
One of the less believable, yet very necessary, parts of the movie features Keanu Reeves as Keanu Reeves. Well, it is a more satirical, less personable version of the fan favorite movie star but Reeves cameo is one of the best parts of the movie. He appears in a scene where Sasha and Keanu go on a double date with Marcus and his eclectic girlfriend. Though some of the film alludes to commentary on gentrification in little lines here and there, this restaurant and its dishes are the epitomai of what is wrong with change due to anything trendy in areas once occupied by a population of mostly people of color, like San Francisco. The restaurant is expensive and has dishes where wearing headphones is part of the experience. This scene is a catalyst for the ultimate realization for the two former childhood best friends. As the real personalities of all four characters, even the fictional Keanu, is displayed, Sasha and Marcus are pushed closer and closer.
Always Be My Maybe is an easy watch and an excellent return to the fun romantic comedy genre. The progression and development of the characters along with the onscreen charisma and talent of Ali Wong and Randall Park is worth the watch. Plus, Keanu Reeves as Keanu Reeves, enough said.
Ali Wong
Always Be My Maybe
Female Directed
Nahnatchka Khan
Between Realism and Empowerment: Queer Coming-of-Age in Netflix's 'Young Royals'
In Wilhelm and Simon, viewers find an authentically told story of queer love, loss and growth, set amidst the ups and downs of adolescence.…
Ferdinando Cito Filomarino, Director of 'Beckett', Discusses Cinematic Influences, Detailed Locations, and Crafting a Confident Thriller
With his genre-colliding new feature Beckett coming to Netflix in August, filmmaker Ferdinando Cito Filomarino spoke with Film Daze's Nathaniel Brimmer-Beller on crafting the…
Shea Vassar
Cherokee Nation writer and filmmaker, staff writer for Film Daze, huge Oklahoma City Thunder basketball fan, active defender of Rogue One, and lover of carrots and coffee (but not together)


Hope On the Other Side of the Door - Podcast is a passion project by Dr. Ken Campos MD, DFAPA. Dr. Campos is on a quest to help caregivers of mental illness family members, specifically schizophrenia. After 25 years of helping patients in hospitals and prevention centers, he became compassionate about helping the caregivers and family members that cope daily and wanted to provide a community to get them support. In this bi-monthly interview series, Dr. Ken Campos talks to practitioners, caregivers, non-profits, family members and other community support resources. He is passionate about creating a clearing for a balanced respectful life for those with schizophrenia and their caregivers internationally. Please Join him and share with other care givers of schizophrenia.


SCB series introduces world advanced technology and equipment. It is the perfect combination of crushing technology and mechanism, showing new technology and process. It is mainly applied to highway, railway, construction, govemment project, cement mixer station. It is the core equipment in artificial sand and aggregate industry.
•Long service life of wearing parts and the application of special iron and kentanium can reduce operation cost.
•This machine with large application range and crushing styles could have "stone stricken by stone" and "stone stricken by iron".


posted: August 26, 2016 by: Angie Tags: "Clinic Specials" "News"
We would like to extend a warm welcome to Dr. Michelle Taddie. She has recently joined our practice, which will help us better serve our clients and patients. She is a recent veterinary graduate from The University of Pennsylvania. She grew up in western Pennsylvania which fostered her interest in both small and large animals. She is great addition to our team and we enjoy her expanded knowledge and enthusiasm to work with our clients and patients. We hope that you get a chance to stop by our office to meet and greet with her or on a future farm visit. We know that you will enjoy her as much as we do.


We are looking to recruit a talented Junior Immersive Media Developer to support a growing team of developers based in Bristol.
The successful candidate will be working to develop a variety of interactive experiences, including VR and AR, to communicate and interact with engineering and architectural design. You should have a good understanding of the Unity development environment and be passionate about developing your skills further.
You will be part of the Creative Design practice, who are based in key locations throughout the UK, consisting of 50+ talented designers, developers and visualisers who provide a professional visual communication service to its UK and worldwide markets.
We deliver world class interactive solutions to a wide range of Atkins clients including EDF, Highways England, Environment Agency and HS2.
• Collaborate effectively with a high energy team of developers and producers.
• Support our interactive developers to produce high quality digital experiences.
• Help develop C# program solutions for Unity.
• Test and debug new features and VR prototypes.
• Use in house tools and plugins to setup new projects.
• Ensure consistent quality and performance.
• Tracking of time spent on project tasks and communicating these with project leads.
• Minimum 2.1 university degree in games development, computer science or similar.
• Strong knowledge of the Unity engine.
• Good working knowledge of C# and OOP.
• Strong maths and problem solving skills.
• Knowledge of 3D file formats, concepts and techniques.
• Good time management and communication skills.
• Experience with VR platforms and hardware.
• Experience with 3D modelling and texturing.


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The Coal Men
Dave Coleman | Dave Ray | w/ Paul Slivka
THE COAL MEN | Pushed to the Side
Press | EPK – Pushed to the Side
PRESS | EPK – Escalator
Press | EPK – Skeletons
dave coleman
Coachella Valley Weekly – Review – "Pushed to the Side" – The Coal Men
Posted on August 11, 2016 by Dave
THE COAL MEN "Pushed To The Side" (Vaskaleedez Records)
By Admin | August 11, 2016 at 6:08 pm |
By Eleni P. Austin
When you think about Nashville, chances are you think about women in rhinestones and spangles, men in cowboy hats, boots and spurs, inevitably those bro-tastic backwards baseball caps.
40 years ago the charts were populated by Willie, Waylon, Merle, George, some Johnnys' (Cash and Paycheck), and some Charlies' (Rich and Pride). These days names like Blake, Jake, Luke, Brantley, Brad, Tucker and Kip, (seriously, Kip) rule the airwaves.
Luckily, anyone yearning for music a little less genetically modified and a little more home grown will be relieved to find that kind of authenticity is still readily available in Music City. You just know where to look.
Artists like Sturgill Simpson and Chris Stapleton have flipped the script, concentrating more on song craft than showmanship. By dispensing with the artifice they've each gotten down to the grit and grain of Country music, opening the door for other like-minded artists.
Dave Coleman is one of Nashville's best kept secrets. He grew up near the Big Fork National River, in rural east Tennessee. He considered becoming a park ranger like his mother, but those plans changed once began playing music in his first band. Rock & Roll was his first love but he soon became inspired by Country outliers like Dwight Yoakam, Marty Stuart and Billy Joe Shaver.
Just as he was finishing his studies at Nashville's Belmont University, Dave signed a publishing deal with Acuff-Rose. The venerable publishing house began in 1942 and was responsible for hits from Elvis Presley, Roy Orbison and the Everly Brothers. It was around this time he hooked up with drummer Dave Ray.
The duo began gigging around Nashville at the end of the 20th century as the Coal Men. They also made ends meet playing on sessions and touring with artists like Matthew Ryan, Jessi Alexander and Taylor Swift. Mentored by the likes of John Prine, Todd Snider, Buddy Miller, members of the Mavericks and the Delevantes, slowly but surely they built a solid following.
Between 2001 and 2013 they recorded an EP, and four full-length records. Nowhere's Too Far arrived in 2004, Kids With Songs popped up in 2006. A year later they released Beauty Is A Moment. Bassist Paul Slivka, who made his bones with Tommy Conwell & The Young Rumblers, Tony Joe White and Tommy Womack, joined the fold in 2011. Two years later the trio recorded Escalator.
Since then, their music has been featured in hit television series like "Nashville," "The Deadliest Catch" and "Sons Of Anarchy." Several times a year they spend week-long residencies at the infamous Key West venue, Hog's Breath Saloon. Now the band has returned with their latest long-player, Pushed To The Side.
The album glides into gear with "Depreciate." Over a teardrop rhythm, languid Spanish guitars and roiling bass-lines comes Coleman's slow-as-molasses vocals. The lyrics offer a crisp metaphor for aging: the decrepitude of the touring van, from the van's point of view. "I'm ready for the junkyard, counting down the miles/I can't remember all my travels, but boy I road'em out in style."
Three tracks, "Willy Jett," "Lilly Hurst" and "Travis" co-written with Jeff Wickland, offer the kind of rich and evocative storytelling woefully absent from today's "I got drunk in my truck and put my toes in the sand" Country music. Downcast baritone guitar notes and a kick-drum beat open "Willy…" The lyrics weave a vivid yarn of a lonely coal miner.
After a brutal week in the mines he seeks solace in alcohol and paid companionship; "Willy came down from the coal camp, dreaming of a woman on his arm/And he found one down on the corner, Lily took him with all of her charms." Of course, hard living has taken a toll…"He lived by a quicker minute, and drifts further away each night/Bound by the weight of hunger, the burden of an appetite."
Sun-dappled guitar, a wash of keys and tick-tock percussion anchor "Lily Hurst." The lilting melody and instrumentation belies what is essentially a traditional murder ballad. Lily is the same working girl that hooks up with Willy, but this time she runs afoul of a jealous customer "needin' comfort and rest," but finding Lily already "doin' what she did best." The end isn't pretty; "Which man she was with, I guess I never did hear/ He drew a line left Lily bleeding ear to ear."
"Travis," is the saddest saga of all. Honeyed guitar licks brush up against a supple shuffle-rhythm and roiling bass. With an economy of language the song sketches a portrait of teenage ennui at the tipping point; "Travis lived 'cross town by the railroad track, just his dad and four walls of a dying shotgun shack/His mind was restless, it ached and it groaned/He walked this town, head hung down, most days he stayed stoned." His suicide is swift, but Coleman reserves his righteous indignation for the indifferent town that never saw it coming.
Three tracks take a break from (to paraphrase Mr. Mojo-Risen) from wallowing in the mire. "The Payoff" is a hard-charging tune powered by a bludgeoning back-beat, driving guitars and Coleman's rough-hewn vocals. The message here is the end rarely justifies the means.
"Fast Driver" is a sly charmer. Snap-back bass, rattle-trap rhythms and wicked guitar licks take a backseat to Coleman's lascivious drawl. He almost has the listener convinced that he's the first guy ever to use driving = sex metaphor. Meanwhile, "Speeding Like A Demon" hooks a shaggy dog, 'speeding to reach the gig' yarn to an infectious melody that's equal parts Bakersfield Buckaroo and Cash-tastic boom-chicka-boom.
The action slows for two songs, "Faithless Eyes" and "A Name." The former is a twangy two-step that is a kissin' cousin to the Eagles' "Lyin Eyes." The latter is a High Lonesome haiku that notes no matter how we try to out run our legacies, DNA doesn't lie.
The Coal Men completely color outside the lines on the tribal "Stones River" and on the gutbucket blues of the title track. "The Singer (In Louisville)" closes out the album. A clangorous note of feedback provides a through-line that crackles and sparks for the entire song. With a few deft strokes Coleman presents a not-so-glamorous portrait of life as a working musician. It's a rollicking end to a great album.
Pushed To The Side is keen and uncluttered. The music of the Coal Men may not be famous, but it's authentic.
This entry was posted in Uncategorized by Dave. Bookmark the permalink.


text:
MCManager is a Bukkit inspired Forge mod for managing a server. The goal is to provide server admins with the tools to run their server without the extra hassle. The mod uses a web server to provide a web interface for server management as well as in games commands and utilities.

Installation:
	1) Install Forge
	2) Add jar to mods folder
	3) Run server

Configuration:
	TODO:

redpajama_set_name: RedPajamaGithub


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The Original Platforming Powerhouse (Image Courtesy of "Nintendo Life" and Nintendo)
"Super Mario Bros. 35" Gameplay Impressions
Jake Pierce
Oct 27, 2020 Updated Oct 29, 2020
Nintendo has released an absolute deluge of content featuring their flagship "Super Mario" character in celebration of the 35th Anniversary of the original release of "Super Mario Bros." on the Nintendo Entertainment System. At the beginning of October, "Super Mario Bros. 35" made its way onto the Nintendo Switch eShop as a free download for all Nintendo Switch Online members. This title seeks to reintroduce the original gameplay of that classic "Mario" experience back into a modern gaming space, both for players who have fond memories of crowding around their NES consoles 35 years ago and those who wouldn't be born until much later. With a modern release comes a modern twist, and here that twist is massive online multiplayer functionality.
Make no mistake, at its core "Super Mario Bros. 35" looks and plays nearly identically to that original game, but that tried and true gameplay has been adapted into a "battle-royale" style contest with up to 35 players to be the last Mario standing. Players are tasked with making their way through classic "Super Mario Bros." stages, all while keeping their timer from ticking down to zero by defeating enemies, collecting power-ups, and doing anything it takes to add more precious seconds to the clock. Players can use a basic, four-option targeting system consisting of random, attackers, lowest time, and most coins settings to send all of the enemies that they defeat as they play to invade the screens of other players. Enemies are flying around between screens constantly leading to situations in which normally safe corridors can suddenly be utterly overrun with Goombas, Koopa Troopas, Lakitus, and more. It can all get very chaotic very quickly, but thankfully the game's targeting system tends to take care of offensive play, automatically freeing up players to focus on navigating the absolute lunacy that they are often presented with.
Perhaps the greatest strength of "Super Mario Bros. 35" is the way it rewards skillful play. Defeating more enemies in your game means sending more obstacles to your opponents, making it ever more likely that they will become overwhelmed and get KO'ed. Players who go out of their way to collect coins are also at an advantage, as the game allows you to spend 20 coins to roll a Mario Kart-style item wheel for an extra power-up. Being able to adapt to any situation and keep a level head when surrounded by threats is the real key to victory in "Super Mario Bros. 35," and the lack of any in-game purchases whatsoever means that concerns of the game creating a "pay-to-win" online ecosystem is not an issue.
Unfortunately, while the gameplay itself may be fantastic, it's in everything surrounding that core gameplay where "Super Mario Bros. 35" begins to crumble a bit. For an online multiplayer game, this title doesn't do a particularly good job at making players feel like they're part of a large, interconnected ecosystem. Matches are entirely one and done affairs, and there's no way to see the usernames of past people you've played with, follow other players or integrate your Nintendo Switch Friend List. There's absolutely no option for you and a friend, whether through local or online play, to join the same match together. The only hope for something like this to happen would be for you and your friend to join at the exact same time and pray that the game just so happens to place you in the same room out of potentially thousands.
The game also lacks a sense of progression. Through the course of a match, every player who is eliminated has their current coin total added into a pot, which is then awarded to the eventual winner of that game along with a set amount of bonus coins. However, the only thing that these coins can be used for is to provide yourself with advantages at the beginning of a match, such as starting off the game as "Fire Mario." This ends up being a moot point though, as not only is it easy to find power-ups during actual gameplay, but the items are also incredibly cheap to purchase. Many players will likely end up with thousands of coins that they simply can't spend, and when the only thing that completing matches rewards you with is more coins, it all begins to feel a bit aimless.
"Super Mario Bros. 35" is a very novel concept and a fantastic example of putting a modern twist on a time-tested retro base. The gameplay itself is strong, with the fast-paced platforming of the original "Super Mario Bros." being successfully merged with a simple and intuitive multiplayer battle system. However, this is also a title that I can see a lot of people burning out on very quickly, as there are no real systems at play here to keep competitors coming back for more. If you're looking for a way to step back to the very beginning of Mario's storied past, "Super Mario Bros. 35" is certainly worth a download, but the longevity that each player sees from it is almost sure to vary wildly.
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based on TLS 1.3 [TLS13].
DTLS protocol does not compensate for lost or reordered data traffic.
order in case datagrams are lost or reordered.
the TLS HelloRetryRequest message (see Section 5.1 for details).
once all previous messages have been received.
2.  DTLS adds an epoch and sequence number to the TLS record header.
reduced from those in previous versions.
DTLSCiphertext header are set to 001.
C: The C bit (0x10) is set if the connection ID is present.
means an 8-bit sequence number, 1 means 16-bit.
L: The L bit (0x04) is set if the length is present.
an implicit one, carried in the sequence_number field of the record.
sequence_number initially being 0 for each epoch.
same epoch and keying material as the original transmission.
records.  The final record in a datagram can omit the length field.
record.  Records MUST NOT span datagrams.
timer to the initial value.
in the same UDP datagram as handshake records.
provide order protection and may not provide replay protection.


Let's try something a little different this week.
You find the following items on a list. What do they have in common? What kind of list might this be and why?
Example: If you found a list that said "onion, carrots, potatoes, beef", it might be a grocery list and perhaps the list-maker was putting together a stew.
The producers of The new adventures of MacGyver really wanted to top themselves for bizarre escape scenarios.
Reason: I'm not sure I want to imagine what the duck would be used for - here's hoping it's more of a verb and less of a noun!
He looked over the list slowly. Duck, chair, elbow, banana. As a group, they didn't make sense. People would think he was crazy if he walked into a store and asked for this particular list of items. But he had the insight to know that each item had its own special meaning to his daughter. He smiled and shook his head at the same time. It would be a shopping trip to blog about, that is, if he got his rear end in the car. His time was running out. Gracie would be done with preschool in 2 hours. Motivated by the sheer lack of time to procrastinate, he folded the list and put it neatly into his wallet.
Target was about a mile away. It wouldn't take long to drive the distance, but he thought he better factor in 15 minutes. Parking would be a practice in patience. He would need another 15 minutes to check out and 10 to drive to the preschool if he was going to be on time. That left him just under an hour and a half to find the items on the list. He grabbed his keys and practically ran to the garage, starting the car and turning left out of the apartment complex toward Target.
"Excuse me Miss," he said after futilely searching for the items on his own, "do you have any miniature ducks?" She looked at him intrigued from what was probably a hectic yet mundane shift.
"A what?" she said, half smiling.
"A miniature duck. My daughter wants one as a pet for a doll." The associate started to laugh, but waved at him, indicating he should follow her. He tried to wedge himself between the shoppers, their carts, and the random piles of boxes left by over trusting shoppers. She easily out paced him. Still ,he kept moving to the end cap he saw her disappear around. She was standing a few feet down the isle, flipping through packages on hooks.
"There you are!" she said, never taking her eyes off the packages as her agile fingers continued to flip through them demonstrating obvious experience. "This is the doll house section. There should be a little yellow rubber duckie in here somewhere. If its too small, you could try looking in the bathroom department. They will have bigger ones that might work." He looked at her with a great deal of appreciation. The little duck wouldn't work. He'd have to force his way to the other department, but he should be able to find the chair she wanted for her doll house here.
"Forget the duck. I'll get the bigger one. Do you think you can help me find a chair for her doll house?" She quickly moved to a section a few steps closer to him and pulled out three chairs. He chose one, dropping it in his basket. "Do you sell replacement parts for those new robotic dolls? Her's needs a new elbow. The last one was crushed in the car door." Sure enough, she was off and running to a location a few isles away.
"Anything else?" she said, smiling at his absurd list and his long handsome face.
"A banana. But I am guessing I can find that in the grocery section."
She nodded. "Unless it is something she needs for her doll again."
He laughed. "Not this time. It's for what I hope will be fabulous banana splits. It's a Christmas Eve tradition for the two of us."
"Well, I hope your Christmas is merry and that she is getting everything on her list." She smiled one last time and turned to help the new costumer tapping her on the shoulder.
He walked away smiling. Once he picked up the rubber duckie, he'd have everything on her list. He checked his watch as he entered the bath department. He had 35 minutes to spare. That would be enough time to actually take the gifts home and hide them for the next two days. It was going to be a good Christmas.
Trip on a banana peel to get a sure laugh.
Silly words like "elbow" might work in your gaffe.
Might get them to crack.
Then fall of a chair, when it breaks in half.
This is a list of some of the many ways I have injured myself - running over my own foot with my wheelchair, forgetting to duck as I closed the upper cupboard door, smashing my elbow repeatedly on the corner of the counter that sticks out just an inch too far, and choking on a piece of banana (because slipping on a banana peel is so overdone apparently and I have to be different and unique in my injuries). Also on the list are stabbing my leg with a pen through my blue jeans pocket, dripping hot glue onto my fingers, pouring shampoo into my eyes when I missed my hair, and stapling my own finger, among others.
I was walking through the cafeteria, when I heard one of my students yell, "Mrs. Victory, Duck!" At the same moment, a banana came flying toward my head. In an attempt to dodge the tropical projectile, I slipped and banged my elbow on a chair. It turned out I had walked into the middle of a food fight. After I picked myself up and dusted myself off, I made the rabble-rousers clean up the mess. It is a day I will never forget.
Today I was sitting in a chair doing what all my teachers had always yelled at me for--tipping it back on 2 legs. Suddenly a duck came by the window. In my excitement, I fell backwards in the chair, managing to bruise the side of my face. I returned to my feet, dazed, only to forget that I had previously been eating a banana. I slipped on the peel of the banana, and fell once more, dislocating my elbow.
This is the list I would make if my almost-4-Yr-old granddaughter Emily were coming for dinner.
1) Duck down and give here a hug. I oves me some Em hugs.
2) Chair - have a chair ready by the conter so she can help me make dinner.
3) Elbow - we're making macaroni, a stellar kids favorite.
4) Banana - hile the water is boiling, we'll cut up a banana and put it in the pudding to have for dessert.
Lots of carbs, but great fun.
Oh, davidseven, we totally need a MacGyver remake!
In second grade, my teacher wouldn't assign homework on Monday nights because that was MacGyver night. I had a crush on both MacGyver AND Mr. Rounds.


As everyone is now looking for the price and updates on Jio Coin because of the owner behind Jio is Mr Mukesh Ambani and why everyone is looking forward to investing.
Global Customer Support Technical Publications: Overview. dated May 2016 has been released as an incremental update on IML.Existing circulation, market capitalization, volume of transactions and more details of Bitcoin.
Latest Forex news from all over the world. with inflation coming out within expectations and the current account beating forecasts.Get updated to the latest news, breaking news, news updates, pakistan news, live tv, live streaming, urdu news, news today, live news, entertainment news.
Watch to learn the latest update on The Billion Coin as we get ready for Blockchain migration and testing of the Fiat Exchange Also below are important links for your.
Latest E-mail update on OneGram Coin. in the unlikely event that any coin holder is not in agreement of the current business direction OneGram has taken,.
The swap will not be done on 1 Jan, so we still have time to transfer the coin to their new wallet before the swap.
Here are some of the most recent updates you should know about. Latest News. Java Update is a feature that keeps your Windows computer up-to-date with the latest Java releases.Hello Friends, join my telegram channel:- in this video i have shared with you latest price update on tron(TRX) coin. in this video i have shared now that to do with.
The token of Royal Kingdom Enterprise, represented by the acronym RKC, a Dubai company that invests in projects.Our 2 in 1 rate tools provides bitcoin current exchange rate, live price update in 163 currencies.
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text:
რუქა
ალენდარი
გადმოტვირთვები
პროგრამის შესახებ
იპოვნეთ პარტნიორი
პროცესის მიმოხილვა
საუკეთესო პრაქტიკა
როექტის მენეჯმენტი
1. October 2020 @ 8:00 - 28. March 2022 @ 17:00
Events for international exchange projects
The JOE List for young Eastern Europe experts in Germany always provides a number of events in English/German. Keep yourself updated here https://www.joe-list.de/
7. December 2020 @ 8:00 - 24. January 2021 @ 0:00
Info: German-Ukrainian funding programme "Culture for changes" by MEET UP!
Apply now in the funding programme that aims at intensifying relations to Ukraine and strengthening German and Ukrainian young people in their commitment to basic democratic values and international understanding.
Nazi Forced Labor: History and Aftermath (Digital Winter School)
The third edition of the winter school goes digital. It will provide a forum for educators who want to exchange ideas on methods and teaching practices on the topic of Nazi forced labour and its memory in postwar Europe from a transnational perspective. The winter school will also focus on how educators can use the documents archived at the Arolsen Archives, which comprise among others multi-million page collections of records on forced labour, including the situation of Displaced Persons after liberation. Furthermore, the participants will have the opportunity to develop a teaching unit, a workshop, or a presentation in small international teams, using the material and digital tools provided by the Arolsen Archives and the Nazi Forced Labour Documentation Centre. The compiled output could be used in their own work with pupils, students or adults.
March 25 @ 8:00 - March 26 @ 17:00
25-26 March, 2021 SDG Global Festival of Action
The SDG Action global community's annual meeting place is returning, larger and bolder than ever! No longer confined by a physical location, the SDG Global Festival of Action will meet you where you are.
აფინანსებულია
#CivilSocietyCooperation


Do you ever stare at those coordinated trees in magazines and wonder what it is about it that looks so good? It's really just unity. A common theme of color throughout the tree. Garland is a great way to do that and I have found 10 Great Christmas Garland Ideas you can use on your tree. This is my tree. I use grapevine Garland. I love the rustic look against all my glass ornaments.
There is always the old standby of Popcorn and Cranberries but if you want something a little different here are 10 great ideas!
Do you use garland on your tree? What do you use?
I've used jute webbing the last couple of years and I love it!


18) If it was said that the Qur'an was a book which was written by Muhammad () in order that a society steeped in immorality be led to morality, can this assertion be denied?
One: There have been no two opinions about the fact that Muhammad () was truthful. It is illogical, therefore, to assume that such a one as he would then, in the name of moral revival, attribute a blatant falsehood in the name of God. It is unbelievable that a person who persevered for the cause of morality would then committ, for the same cause, a gross immorality. What, indeed, can be a greater sin than attributing lies in the name of God?
Two: The Qur'an itself has declared that the worst transgressor is the one who invents lies in the name of the Lord Creator and the one who writes something and then says that it is from God. "Who can be more wicked than one who inventeth a lie against Allah, or saith, 'I have received inspiration,' when he hath received none, or (again) who saith, 'I can reveal the like of what Allah hath revealed'?" (6:93). If the Qur'an is, indeed, Muhammad's own work, then the 'most wicked' one mentioned in this verse must necessarily be he himself. Will he have condescended to describe himself as the "most wicked" and to preserve it in writing too?
Three: God has cursed those who write with their own hands and then attribute it to God. "Then woe to those who write the Book with their own hands, and then say: 'This is from Allah'." (2:79). If the Qur'an is, indeed, the work of Muhammad (), then this curse is most applicable to him . Consider this : to makes one's own composition; then to proceed to curse one's own self. Is this believable?
Four: The Qur'an is not a book that was revealed all at once. The verses of the Qur'an were, in fact, revealed over a long period of twenty- three years and, that too, under varying circumstances. Indeed, in some cases, the verses of the Qur'an were revealed as a direct answer to the questions posed by the people. There are, in the Qur'an, around fifteen occasions wherein the verses which employ the style "they ask thee (O Muhammad) concerning…" and "Say (O Muhammad)…" have been used. It is evident from this that there were occasions when the Prophet could not provide a satisfactory answer to the questions of the people on a topic and that it was only later, with the revelation of the verses of the Qur'an, that this became possible. If the composition of the Qur'an was, indeed, the work of the Prophet, who sought to bring about a moral revival, he would have been able to answer the questions of the people as and when they arose. For instance, if it was the Prophet's intention to save the people from the evils of drinking and gambling, he could have straightaway declared them to be sinful.Instead, that was not done; without making his own statement and he awaited the arrival of the divine revelation. It was only after the revelation of the divine verses that he sought to take action against these evils.
If the Qur'an was really the composition of the Prophet, which he had made for the moral transformation of the people, would there have been verses in the Qur'an which criticized his own actions?
Previous PostPrevious 17) Can it not be professed that the Qur'an was a book composed by Muhammad () with the objective of uniting the quarrelsome Arabs and to, thereby, lead them to the heights of greatness?
Next PostNext 19) Could it not have been that Muhammad ( ) suffered from Schizophrenia and that the feeling of revelations was but a symptom of that disorder? In fact, was he not called a madman by his contemporaries?


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Q: GDAL libraries, who does what I'm struggling installing GDAL on ubuntu 16.04 to work with GeoDjango (Django 2.1, python3), so I need to understand what I'm actually installing.
What is the rôle of each library/package/module ?
apt

*

*gdal-bin (A 'C' library containing the actual functions ?)

*python-gdal (The same in python, or just some kind of bridge ?)

*python3-gdal (see above, but for python3. Does it need python-gdal ?)
pip

*

*gdal

*pygdal

What is the link between pip modules and apt packages here ?

A: Every piece of info is available, if one is willing to search for it.

*

*DEBs (installed system-wide):

*

*gdal-bin ([Ubtu]: Package: gdal-bin) - a collection of gdal related binaries (tools and utilities)

*python3-gdal ([Ubtu]: Package: python3-gdal) - Python 3 bindings, extensions (.sos) and some wrapper scripts, which enable gdal usage from Python

*python-gdal - the same thing, but for Python 2 (totally unrelated to previous item)

*WHLs (installed as Python modules to the interpreter used to launch pip):

*GDAL ([PyPI]: GDAL) - the sources (.tar.gz) for #2. (and / or #3.). During pip install phase, they are built and installed for current Python

*pygdal ([PyPI]: pygdal) - same thing (but for VEnv?) as previous item. It seems to be a lighter version (it doesn't contain the scripts)

But, all of the above depend on libgdal ([Ubtu]: Package: libgdal1i), which is the gdal library.


This is only for the cost of the interim antenna and line sweep. It does not include any of the other costs associated with this invoice.
UHF - High Power, Side Mount, basic slot antenna, 15 kW input, horizontally polarized Information not provided.
This is only for the cost of the main antenna and line sweep. It does not include any of the other costs associated with this invoice.
Only including the cost to remove the main antenna and install the new main antenna. This does not include the install or removal of the interim antenna.
This is the second invoice for this work. This covers the cost of the install and removal of the main antenna. It does not include the cost of the install and removal of the interim antenna.
This is the second invoice to cover the cost of the install and removal of the interim antenna. It does not include the cost of install and removal of the main antenna.
This is the cost for the install and removal of the interim antenna. It does not include the cost of the install and removal of the main antenna.


This indicates the number of step-in the procedure.
This is the most important component in the pricing procedure. The rates are picked up from this element, on the basis of the properties described.
This forms the description of the condition type.
This function enables to allow the condition type to be entered manually also apart from automatic pickup.
This function identifies the conditions that are mandatory in the pricing procedure. The sales price is a mandatory condition type.
The activation of this function will enable the printing of the values and conditions to the document.
This function is used to assign a requirement to the condition type. This requirement can be used to exclude the system from accessing the condition type and trying to determine the value. This can be used to specify that the condition type should only be accessed if the customer has a low risk credit.
This function allows you use a formula as an alternative in finding the value of the condition type, instead of standard condition technique. this can be used to calculate complex tax structures.
N. ALTERNATE CONDITION BASE VALUE.
The alternative condition base value is a formula assigned to a condition type in order to promote an alternative base value for the calculation of a value.
The account keys form part of account determination. These keys are used here to define the posting of the revenue generated to respective account heads& to subsequent assignment to GL accounts.
The accrual keys form part of account determination. These keys are used here to define the posting of the revenue generated to respective account heads& to subsequent assignment to GL accounts and payment to respective parties.
For example if you want to use field PSTYV ('Sales document item category') that is included in structure KOMP ('Pricing Communication Item') as a key for a condition table.
When you create a condition table (Transaction V/03), however, the system does not propose the field in the field catalog.
For technical reasons, field PSTYV was included in structure KOMP, however, not in structure KOMG ('Allowed Fields for Condition Structures').
1. Call up the ABAP Dictionary (Transaction SE11) and create data type ZZPSTYV. Choose PSTYV as a domain.As a short text, you can use, for example, 'ZZ – sales document item category' and as a field label, you can use the field labels of PSTYV.Save, check and activate your entries.
Save, check and activate the change you made.
3. Note:Because of the change in structure KOMPAZ, field ZZPSTYV is now known in structures KOMG and KOMP because structure KOMPAZ is included in both structures.
4. Call up Transaction SPRO. Navigate to 'Sales and Distribution -> Basic Functions -> Pricing -> Pricing Control' and execute 'Define Condition Tables'. Choose 'Conditions: Allowed fields' and include ZZPSTYV as a new entry.
5. Note:Now you can use field ZZPSTYV as a key field when you create a condition table Axxx.
In order processing you find the user exit in Include MV45AFZZ, and in billing document processing you find it in Include RV60AFZZ.
KOMKAZ instead of structure KOMPAZ and USEREXIT_PRICING_PREPARE_TKOMK instead of USEREXIT_PRICING_PREPARE_TKOMP.
Technique) -> New Fields for Pricing' and Note 21040.
1) There are almost all the regularly used Conditon Table predefined in the system from 001 to 500.
See what best you can use the Standard Tables to avoid further errors.
Press execute and reach to next screen.
c) Check up whether the field you are looking is already added in Field catalogue.
d) Double click on the fields you want to make a Table..one by one. Note that the sequence here is important in higher hierarchical to lower..
e) After selecting, click on the Techincal View buttin (redone) and reach to next screen.
7) Check which key should be in header and which key should be footer. Use check and uncheck functionalities there..
8) Once you are through with all the above steps ..click on generate button.
Check the Table is generated or not.
You can check it at V/04 or V/05 or in SE11.
1. Why we are maintaining separate pricing procedure for inter company sales and business processs.
2. What is the different between standard and inter company pricing procedure and what type condition type we are using in this intercompany.
There are two simple reasons for making any Pricing Procedure in SAP SD Modules.
goods or render services, is all about the reason for various pricing procedures.
– A High Discount oriented pricing Procedures.
– A repair pricing procedures.
You have your own conditions intended to few transactions only. Put all this conditions as a set defining your own Procedures. It may even include special requirements and formulas applied for such Pricing Procedures.
pricing procedure. SAP Standard programmes checks these special Indicators in-order to do some required functions.
As a example 1, you need to have a Pricing procedure for condition supplement inorder to use the condition supplements. The condition supplement pricing procedure must be given in the condition type definitions (v/06) of the Pricing Condition where you need to supplement, without which SAP SD Condtion Supplements functionality doesnt work.
As a example 2, you need to have a Pricing procedure for Inter Company Billing Conditions(IV01 & IV02) inorder to be active for Inter Company Billing specific transactions. Thus make sure that, the procedure wouldnot apply for non-Inter company transactions.
Here I would like to remind about a important field in pricing.
In V/08 of defining a new Pricing Procedure, in main screen, you have a field called TSPP (Transaction Specific Pricing Procedure). This has to be ticked on for Intercompany Billings.
Before Release 4.0A, no special pricing procedures were used for intercompany billing and rebate credit memos, programs were just set accordingly to deal with these situations. As of Release 4.0A you are offered greater flexibility in the form of the option to define special pricing procedures for intercompany billing and rebate credit memos. For reasons of future compatability, you will still be able to use the old program specifications. For this reason, you must set this indicator if you want to create a special pricing procedure. This is to prevent the program settings being used.
This indicator is also used as of Release 4.0A to redetermine the condition class and the statistical condition indicator when copying from a reference document.
You copy prices from a shipment document to the billing document. The prices should lead to a surcharge in the billing document. This is guaranteed by the redetermination of the condition class in the pricing procedure.
Same case with Standard Pricing procedure or Inter Company Pricing Procedure.
This configuration is done when user request for new pricing condition type other than the standard ones provided by the system.
e.g. a business may no longer wants to have a sales discount based on the sales organization, customer group, and material, but decided that the discount should be based on the sales organization, customer group and material group.
V/06 – Create new condition types by copying a similar conditions type and changing it according to your needs.
V/08 – Pricing Procedures for condition types.
The pricing procedure is also used in the account determination. This determines the general ledger accounts to which prices, discounts and taxes must be posted.
OVKK – Determine which Pricing Procedures to use for which Condition Type.
You can add additional decimals for a currency through a work around method.
Set up a currency let's say instead of USD call it US$ ( OY03 ) and define the number of decimal places ( OY04 ) to be 3 or more depending on your requirement.
Maintain the exchange rate for between US$ and USD to be 1 to 1 ( OBBS and OB08 ).
Create pricing condition records for those customers requiring 3 decimal places using Current US$ instead of USD.
That will give you 3 decimal places for your prices. However, one thing you will have to watch out for is rounding.
You can try transaction OB90, define rounding rule for currency. Here you define the rounding rule for your customer's currency.
e.g. You create an order type ZP00 for QT – Quotation and does not wish it to be used in OR – Standard Order.
Users will receive Message no. V1 206 "Condition ZP00 is missing in pricing procedure A V ZQT".
In VK12, click the Key Combination button. You can see a list of available key combination for your price master.
Finally, goto VK12 and key in the new price master for PR00.
Next, goto VA02 and test out the material. If it didn't work check the pricing date in the header details. Is the pricing date within the validity period?
You are free to design your own processing status flow.
To convert the old Pricing Condition with the release status use program SD_MOVE_A004_TO_A304.
For example, if you are using A005 –> A305, you have to copy the program to ZSD_MOVE_A005_TO_A305 and amend the program Source and Target table.
First test run by ticking both option. If you confirm that there are no errors, then run by unticking both options.
Be careful while executing the conversion program as it can erase all your existing pricing condition data.
In VK12, you will be able to choose the new Customer/Material with the release status column per material.
Configure the pricing procedure at delivery with the required condition type to determine freight. Also have the copying control from delivery to billing at item level with Price source as D for Delivery. While you execute billing you would get the prices from the sales order as well as from deliveries.
If you were to look at the pricing procedure RVAA01 you will see there was a section dedicated to the various freight charges. Normally, I would use one of the available condition types and create a condition master based on the Incoterms.
It also tells you to create two new includes: ZZAUTH01 and ZZAUTH02, but it doesn't tell you what changes to actually make in any of these. I am assuming that the authority checks have to be added somewhere, but what goes where?
* damit auf jeden Fall Berechtigungsprüfung durchgeführt wird.
* Sicherheitshalber zunächst Berechtigung verweigern.
* if komv is initial.
* Berechtigungsprüfung auf Kalkulationsschema und Stufen-Nr.
IF KOMK-KALSM NE OLD_KOMK-KALSM OR KOMV-STUNR NE OLD_KOMV-STUNR.
OR SCREEN-NAME = 'KOMV-KWERT' ).
In my system (46B) I remember that the subroutines USEREXIT is not changed for this purpose. With SU21 (z_konh_kls I think that you don't have problems), like with SU02.
For procedure you can populate with the procedure (see tcode V/08 ) that you use in your SD documents, or the procedure/s in where you want that the restriction will work, if you have many procedures.
For level, you must write the ranges of levels in this procedures (into V/08 ) that you want that the user can see (remember that alpha routine conversion dont works, ie: for level ' 1' [in dynpro] you must write '001', if not, you will have problems). The levels out of this ranges, the user with this profile when go to conditions in SD document will not see the value of these items.
Finally, in SU01, add this profile to profiles created with PFCG in 'profiles'.
After check if it works.
1. Create the new data element ZZPRODH1. Also create a domain with the length "3" and the data type "CHAR" for the new data element. Remember that new data fields must start with the letters "ZZ" or "YY", since SAP reserved these letters to protect them from being overwritten during a release upgrade.
2. Check whether the product hierarchy (PRODH) is found at header or at item level. In table VBAP, document field PRODH is defined as an item field.
3. Integrate the field name ZZPRODH in the communication structure KOMP using the INCLUDE KOMPAZ and allocate the data element PRODH to it.
5. Check in which table the field PRODH exists.
The field is in table VBAP (sales document: item data).
MOVE VBAP-PRODH(3) TO TKOMP-ZZPRODH. ENDFORM.
7. Allocate the specifications A, V and 001 to the field ZZPRODH in table T681F. Use "E" has been added for fields in rebate processing.
Please note that this is a very simple example. Quite often you have to dig a lot deeper.
Modifications of Copy Control routines, making output forms (thru SapScript) and such requires you to know all the necessary tables, structures and fileds.
The only advice I can give you is to use tx SE11, which will show you the organisation of a table/structure, and can also help you check the contents of a specific table in a specific sales doc.
1. Create a Material of your Motor Cycle using Material type KMAT(MM01).
3. Create a class called Zbike with the above 2 characteristics and save the class.
5. Then create the order and Enter the Kmat material you want in the Order.
Q – In variant configuration I have configured my material properly during sales order creation it is selecting proper characterstics but my question is pricing should calculate at characterstics level not at header level.
A – Pricing in variant Configuration is done at the Header level only. The logic is that you create pricing variant keys for each characteristic Value. This will be done at the Header level using cond type VA00.based on the characteristic chosen the appropriate price according to the pricing variant key will be picked up.
Q – Here my question is with out creating the materials is it possible to get price based on the characterstics.
I am working on variant configuration here my product is 9-100. i have created characterstics for describing colours. this characterstics assigned to class, this class is assigned to 9-100(KMAT type). here i have not created amterial to describe each colour.
Now how I need to setup my system to calculate the price based on colour.
A – A cool Question. It will really get us into the thick of things in Variant Configuration.
Give the description and go directly to Addnl Data Tab.Here in the table name Enter "SDCOM" and in the Field Name Enter "VKOND".The system will pick up the format from the Dictionary.
3. Now go to CT04 and change the Characteristic Zcolour.
Go to values tab and select RED.Goto Extras-> Object Dependencies->Editor and then select Procedure.
In front of 000010 Enter $self.ZCol_surcharge='RED'.
3. Link both these characteristics to the Class(The class which you have attached the KMAT Material).
4. Go to VK11 and the Enter VA00.Then give the values RED and BLUE and enter the values.
5. Go to your order and Enter your material.
Q – Here are some clarifications required from you.
what is the significance of item category group 0002 and 0004. Apart from these are they any other item category groups are available for configurable materials ?
In BOM header material having components. is it possible to make the component as configurable material.
A – The difference b/w 0002 and 0004 is basically that of LUMF & ERLA.
In 0002 the pricing happens at the Header Item Level.
In 0004 the pricing happens at the Sub Item Level.
Check out the Item category Assignments and things will be Clear.
I think these two are the only ones used for Configuration.
Please let me know in which Scenario you would like to have the configurable material Inside a BOM(as it would help me in visualising thh Item Category Assignment).
Q – As you said I setup my system to calculate price based on colour.
ZCOLOUR contains all colours in values tab page.
ZPRICE contains table name and filed name in additional data tab page.
I went to ZCOLOUR characterstics I maintained (extras-object dependicies-editor-action) there I have given $self.ZPRICE = 'RED' for all the values.
when am creating the sales order price is coming only for RED colour not other colours. even price is maintained for all the colours.
A – Seems like there is a mistake in the line $self.ZPRICE = 'RED' (You have said you have given this for all the values- If I have not mistaken). This refers only to red colour.
All this is Case Sensitive. So please be careful.
This entry was posted in 4. Pricing on October 23, 2007 by jiteshdua.
I have two pricing conditions for discounts.
The first one is a percent based. i.e. 15% for all customers in the group but not for the customer group customers that received the second pricing condition – quantity.
How could I omplement this scenario using routines 6 or 38?
* Use standard customer discount conditions – k005 (quantity based) and k007 (percentage based) and create a condition exclusion group.
* Write a routine to include 'customer group' as the basis for selection.
Let me know if this does not help.
I am not getting your question exactly.. but i give you one link there itself you can get the solution..
as we know in SIS there are some field who can be assigned by our self.
can u mention me how to assign the certain condition type into that field (order pricing subtotal 5) in the pricing procedure?
In sales order for specific materials there is automatic pricing that is coming to sales order.
When new price (PR00) is added to item, there is double price for material. Of course this other condition type can be moved manually, but sometimes user don't remember to remove it.
Is it possible to change system, so that when PR00 is entered manually, system would not calculate other condition type for pricing? So basicly system would need to notice that manually entered PR00 is available and do not calculate automatic price to total amount.
I want to display the condition subtotals(Net value before freight) in my report.. can you tell me in which table i get those details.
Go to your home table.
I am facing the problem for condition type VPRS, where amount in sales order & invoice not same ( here there is no delivery document case is Order to Billing ).
Hi, I have a requirement of using more decimals (8) in the condition base value vs the Std SAP rule.
material codes have the alternative UoM set-up, the alternative UoM is the one used for pricing maintenance in VK11/VK12.
however the "std SAP condition base value" is considers only few decimals (I guess 2 or 3) and it rounds at that level.
This triggers a big difference in the unit price value (given by [condition base value * price per alternative UoM], where the condition base value is given considering the conversion factor between alternative and base UoM, one divided by the other as stored in the material master alternative UoM tab) between the "current legacy rule (8 decimals) and the SAP rule".
(this is the result of the conversion factor between UoM). We need to find a way to use the figure with 8 decimals.
This triggers a 4p price difference and with big quantities this is a lot.
The idea of pricing per base UoM is not an option here as that will impact other external applications and important Business rules.
What your thoughts about it?
PS: Apparently only using one custom "condition base value formula" in VOFM (then linked to the pricing schema) is not enough as the "variable" will already contains e.g. 0.278 (based on the previous example).
Hi Pier, do you managed to find a solution to this problem? I'm new to SD and am currently facing the same problem? Hope there's something to new here. Thanks.
I'm trying to set up a price mechanism with a customer, about freight costs.
Is that possible and which are the steps for?
I wanted to configure pricing procedure. The requirement is price is cost plus margin say 10%. The cost is the highest of VPRS and EK01, How to configure this??
Client buys Goods from third party vendor and resale it by adding margin 10%.
Please guide me. Thanks !!!!
A formula for a pricing condition is well computed when creating order in CRM or in R/3, but when the order is transfered from CRM to R/3, there is a redetermination and the formula does not work.
I have Problem About Pricing error in Item xxxxx from VF02 (change Invoice), when i click Icon Accounting.
Material standard cost price is changed at the time of sales order creation.
my requirement is std cost price need to be calclute for the condition EK02 ,while creating the sales order.
please give all your inputs.
I have prepared the sales BOM. My Client wants keeps the stock at header level item, but wants to do the Pricing at item level. It means Pricing at item level & delivery PGI at header level item. I do not know how to achieve this? Any idea. Thanks!
Does anybody knows how to do so?
Total fixed amount surcharge is required.
Reading SAP documentation and what I could find on the interned Header conditoins are only possible manually (and then the total amount is distributed across the items).
Is there a way of applying header conditons automatically (conditons set up – acc.sequence – but applied on header and then distributed across all items) .
I have exactly same requirement.
I have set up surcharge condition as group condition and header and item condition checked. Also have access sequence. But this is not working out for me. Do you have got any solution yet?
This is something SAP has to work on. I am afraid, until current release, header conditions can only be entered manually. A work around could be to create a customized solution with the help of your developers. It will be interesting to know what solution you finally come up with. Please keep us posted.
If we need to do a calculation within a exit during pricing what exit needs to be used and how. Basically we want to bring a condition value in the pricing condition by a calculation in an exit.
Please let us know how can this be achieved?
I am facing problem for profit center. In sales order line item profit center showing correctly but when I prepared billing in VF01 and when finance document created, there in Profit center document I found that profit center is not showing correctly for VAT & debtors GL a/c line item but it shows correct profit center in sales line item in single document. Please let me know where I can check for rectifying the problem.
I am facing problem for profit center. In sales order line item profit center showing correctly but when I prepared billing in VF01 and when finance document created, there in Profit center document I found that profit center is not showing correctly for VAT & debtors GL a/c line item, it shows dummy profit center code for 2 line item, but it shows correct profit center in sales line item in single document. Please let me know where I can check for rectifying the problem.
I have to implement one ESP(Estimated Selling Price) . we need to sum all the line item total and send it to Header condition type(ex: ZESP). It would be great if anyone can throw any light to achieve this type of functionality.
ya sure! see in va02, for item line 10, order quantity is 10, i vl select it and goto pricing conditions, for particular condition type ZHS7, i want to check, its showing me rate as 16% ok, now i vl go back change the order qty to 101 and press enter, it will give me info msg tht new pricing conditon.. after that i vl select it and goto pricing conditions, the rate becomes 0% for that. what can be reason? i check the condition records for that condition type, the rates are not matching wt scale values maintained.
While entering the pricing condition manually in the shipment in vi02 transaction for the delivery items, i get the amount in red color and when i go back to delivery items and select the same one, the condition type which i gave previously is getting vanished.
Can you give me some idea on what is happening? or how to fix this issue?
I also have a complicated requirements for shipment costs. I need to cumulate all items' quantities in order to determine each item condition value. In a shipment cost document there is no total quantity field and the only field that gives me a quantity at item level is KOMP-MLGME or KOMP-MGAME.
Will this be possible? if not I would really appreciate some suggestions.
I am interested in on line Sd functional training, please let me know the complete details.
I have a the following problem.
We sell service item, but the amount posted to the revenue account (for us a balance sheet account) should be split and post on several other account according to a predefined rule based on the material code (let say x1% should be posted on account A1, …., x_n% on account A_n) but in the invoice only the total amount should appear without any detail because it is only for internal purpose.
My idea was to manage n conditions types according on the number of split which sould be done (with the rule sum x_i%=100) and build the effective price of my item. To this total (as if it is my PR00) apply all the other conditions.
hi ram this is raghu u r reliance frnd yeah u r right this blog was very help ful ….
You need to do the required settings for a MTO or Made To Order scenario to create a sales order stock.
what ever you did it is called make to stock process, and what you want was its make to order process, so please configure accordingly for the MTO Process, so that you will get properly.
I would like to know, when I changed the data VALID TO field in VK12, the header data in KONH could not be changed but It shows the changed value. Can anybody tell me which is the actual Table where the current VALID TO field value is stored?
PlZ give the solution for the problem.
while creating the material master and in customer master screens displaying both set of tax codes ZCST,ZVAT,ZSCT,ZSVT and these fields we configured as requird fields.Is there any way to seperate these taxes based on Material type and Customer Account Group.
2.While creating the sale order for Scrap system is taking the tax codes from ZCST and taking the condition value from ZSCT.
plz. suggest the solution for the above problem.
following tips when you enter in the kitchen area.
or methods of your house. Preparing yummy meals can be something that anyone can do, and it's exciting also!
your respective cooking area. Any chaos can be cleaned up!
I have a doubt , can we issue discount on net document value , if so how ??
I'm using a bespoke field in the pricing table to determine price. If I maintain Alphanumeric e.g (double2) the price condition is determined, but when I maintain numeric (eg 1) the price condition is not picked.
Please does anyone knows what the issue could be. I have followed the steps above with help of an abap developer.