Irish residents can now renew their motor tax 24 hours a day, seven days a week, through a new website, www.motortax.ie. The guide included on these pages should be of assistance to you.
You can do all your Motor Taxation and Driver Licensing business by post. Do not send cash by post or through the express postal facility. We accept all major credit and Laser cards.
Telephone No: (071) 9620005 email: ssomtax@leitrimcoco.ie for queries.


text:
Karl-Anthony Towns lost 50 pounds after contracting COVID-19 in January
Madison Williams
Karl-Anthony Towns, the Minnesota Timberwolves center, spoke with Sports Illustrated about the struggles he endured during the 2019-20 and 2020-21 NBA seasons following the grief brought on by the COVID-19 pandemic.
In 2020, COVID-19 took the life of his mother, his uncle and five other family members. This was a nightmare of a disease for Towns as he struggled dealing with the grief of losing so much family, especially his mother.
2021 from the start hasn't been much easier for Towns. On Jan. 15, Towns tested positive for COVID-19. He quarantined for a few weeks and even received treatment in a hospital. By the time Towns rejoined his team on Feb. 1, he had lost 50 pounds.
Karl-Anthony Towns lost 50 pounds after he contracted COVID-19. He thought about stepping away from the game and had the symptoms of a panic attack when he was first cleared to travel with the Timberwolves.
On what Towns went through, and where he is now https://t.co/5yhvNV8RQi
— Michael Pina (@MichaelVPina) September 27, 2021
After missing just five total games combined over his first four seasons, Towns missed 37 games in 2019-20 and 22 more in 2020-21, an abrupt departure for one of the NBA's most consistently available players.
Towns turns 26 in November and — hardened by the trials and tribulations of a tumultuous two seasons — appears ready to move forward and leave his troubles behind.
"I'm like, 'I'm ready. If we had to start today. I'm more than prepared. I'm mentally prepared to go to Minnesota, live in Minnesota, play this game of basketball.' I've been working tremendously hard this offseason. I've been working on not only my body but just working on me," Towns said in his interview with Sports Illustrated. "I think I found some comfort in where my life is right now."
On Monday afternoon, Towns spoke with press during Timberwolves media day where he was asked about the team almost being fully vaccinated and how he feels about other NBA players being vocal about not getting vaccinated. He emphasized how it's everyone's choice to get a vaccine, but he is tired of people making up excuses that make no sense, similarly to what he expressed on Twitter a couple weeks ago.
Every day I see a new excuse why people ain't getting the vaccine. Ya starting to get creative with these "reasons" though and it's actually really funny.
— Karl-Anthony Towns (@KarlTowns) September 15, 2021
"I'm very appreciative of those two players coming forward and obviously knowing that everything's a choice. I'm never going to take away anyone's choice. I can strongly suggest something," Towns said. "Shoutout to those players for seeing how important it was to me and this organization that they went forward."

redpajama_set_name: RedPajamaCommonCrawl


Nowadays, .NET Core is in the top 5 of the most popular Frameworks, Libraries, and Tools. The metaphor of dwarfs standing on the shoulders of giants expresses the meaning of discovering truth by building on previous discoveries and experience. The point is that the .NET team has learnt from their previous experiences and .NET Core is the result of that experiences applied to a new multi-platform framework.
I have already write about .NET Core here: Developing token authentication using ASP.NET Core, Implementing SOLID REST API using ASP.NET Core, Unit testing ASP.NET Core Identity.
The framework is movin' fast, each new release enhance and sometimes change features of the framework. The following article shows some highlights and new feature which are present in the new version of .NET Core 2.1 and ASP.NET Core 2.1.
.NET Core comes with a new set of types for using arrays and other types of memory that is much more efficient. Furthermore, Span<T> and Memory<T> are part of the System.Memory.dll package, the preview of this package is available on NuGet and it is compatibile with .NET Standard 1.1.
Actually, Span<T> and Memory<T> concept goes behind the consumer-use side. Indeed, these new types became useful under the hood of the framework, e.g. for the HttpClient, in order to improve the performance.
The Windows compatibility pack package is useful for all the developers who want to port existing .NET Framework code to .NET Core. It increases the APIs surface to an additional 20k APIs.
Since it detects if the current OS platform is Windows, it may be useful in order to execute different code depending on the type of platform.
In addition, Microsoft has also released the following package: API Analyzer. API Analyzer is a Roslyn analyzer that comes as NuGet package. After referencing it in your project, it automatically provides live feedback on API usage and warns about potential compatibility issues and calls to deprecated APIs.
As you can see, in .NET 2.1 preview the build time for WebSmall project is of 2.7 sec, furthermore for the WebLarge project, the build time is 22.5 sec.
The .NET team goal is to improve it with the new .NET Core 2.1 RTM version. Their plan is drop that again to 6.8 sec for WebLarge project.
Let's talk about ASP.NET Core 2.1. The new release is targeted for mid-year 2018. It covers some improvements and features on following areas: Razor pages, SignalR, Webhooks, Security, Perfomance, MVC, Kestrel; Here is some highlights and new stuff from next release.
The NamedClient is the default choice.
Nowadays, HTTPS is the default choice. Some browsers, like Chrome, starts to apply security policies behind HTTP web applications, please see: Marking HTTP As Non-Secure.
Core 2.1 comes with https by default. In other words, in addition to listing on http://localhost:5000, Kestrel will listen on https://localhost:5001 when a local development certificate is present. .NET Core SDK will install a suitable certificate by default.
In conclusion, the new releases 2.1 provides a lot of useful improvements. As said before, it is based on feedback and suggestion which comes from consumers. It will also introduce some other new stuff, such as web hooks adapted on different provides and also it will re-introduce SignalR.
For more information about the high-level planning and its related issues/features at the following link: Announcements/issues/288.
First time i compiled and run a Blazor project, it made me drool. It's just amazing, specially now that it's been adopted officially by Aspnet repo.
For sure, it lacks lots of feature and tools. But it's a very VERY neat idea. I do think , that if given love from the community, it will have it's niche market.
It's just amazing how you can see those dll's being downloaded on the network tab.
Check the attached pic, how amazing is that?
Obviously, it's too early, but soon it will have AoT compilation and other performance/size optimizations.
Learning React, GraphQL, and Apollo?
Still don't have a dev.to account? You're welcome to lurk, but it's better to be part of the community.


"I have internet. I ALWAYS seem to have the Internet! Is this some Colossal JOKE? How can I possibly have internet any time of day or night without having to reset some stupid box, unplugging it, and plugging it back in over and over and over again…checking the signal strength, changing the APN, resetting the settings until I am blue in the face?...There is great joy in losing this source of frustration.Thank you for improving my life."
"Thanks for coming out and fixing me up with the best internet we've ever had out here!"
I've had their service for 18 months and love it.
Great! Wi-fibre is offering me the same service as Telus, with faster internet, for $140 less monthly. Its also a HUGE bonus to do business locally!


text:
Fractal FM9
By Paulzx,
August 29, 2021 in Helix
Paulzx
Registered Products:1
Anyone checked this out yet? Looks like fractals attempt at a direct helix competitor to me.
It looks amazing in the demo video but they all do don't they!
Have to admit I'm intrigued but I doubt it will knock helix off the top spot, which I firmly believe it does occupy because you simply can't buy anything as good as a helix for the same money, and knowing fractal gear, it will be top notch but it will be expensive.
Has anyone tried one yet?
rvroberts
LocationSydney Australia
Yep - the price will be interesting to know.
I'm sure it's a serious competitor - but I'm invested in the Helix world, so it will have to do something fantastic to make me think about what I expect to be substantial dollars.
For new digital take up and people wanting to upgrade from a pod Go or something else lower spec'd if the dollars are competitive, it might start to take significant market share.
Competition is good for us all - sooner or later there will be a device that's enough of a step forward we will all find we start to get GA$!!
27 minutes ago, rvroberts said:
Agree..just seen the price though.. 1600 dollars or 1100 pounds, which makes it cheaper than a Helix! How the he'll did that happen. Since when does fractal beat line 6 on price?
Had a deeper look at this fractal, so it's a floor unit very similar to helix, they've obviously tried to copy it. It does all the same stuff from what I can see. My question now is, if this thing is bringing axe fx 3 quality tones with it, it could be too good to ignore.
It's so new that I don't think anyone knows much about it yet. I hope line 6 have got another good update for helix soon though. Better tones straight out of the box would be good. That is the one criticism I have of the Helix, it does require a bit of tweaking to get anything really good. We're all used to it by now but new comers may be underwhelmed at first.
I still think helix is the best thing out there right now though, at this price point. The fractal would have to be a decent step up to challenge it in my opinion.
Very interesting conversations going on in the gear page forums about this vs. The Helix. Seems a lot of folks are expecting line 6 to come in with something good to counter fractal.
What we do know about the fm9 is that it has the built in auto wah we want on the Helix and you can change guitar pitch properly. It doesn't have an expression pedal though. Tones do sounds epic but I don't know how much I trust these pro demo videos. My Helix never sounded like any demo video I ever saw, I had to learn how to extract those tones to suit my gear, so I'm sceptical
theElevators
Helix is more user-friendly for me. Both processors have the same capabilities. At this point as a Helix user, there are no sounds that the Helix does not have, which I need.
Which one is better? It's just about the capabilities, processing power, etc. Even though as far as I'm concerned, the Helix is doing just fine with processing power, maybe except poly shift -- there's a slight lag. There's a song where I transpose my whole guitar a step down and it is is noticeably "not together" with my picking.
One more thing... Fractal just has a reputation of being professional touring gear. Line 6 does not for most. I used to scoff when I saw somebody using a Line 6 Spider amp, for example. Now obviously, I'm a Line 6 Helix fan and don't plan on switching to anything. With any guitar processor, once you start using it and spend 100s of hours dialing in your presets, it'd be crazy to abandon it all and start from scratch. Unless of course you just use a pedalboard approach, then it's not so bad. I have 55 presets that I spent countless hours perfecting and am planning on continuing to use them for a long time.
4 hours ago, rvroberts said:
The price is $1599 as far as I know, so exactly the same as the Helix floor. But it's got no pedal :) and has one fewer FS....
phil_m
LocationMinneapolis, MN
3 hours ago, theElevators said:
Not to be nit-picky, but the Helix Floor is selling for $1499 in the US now. They moved some production from China, so they were able to avoid the tariffs that had raised the price since the initial introduction.
LocationOrcas Island
Meh. In this day and age I think it's splitting hairs. The Helix is just fine, thanks and I seriously doubt that the Fractal is going to be 'night and day' better than the Helix. It'll be a very subtle difference no matter which one is better. All the hassle of learning a new system, recreating all the patches that I use on the Fractal plus the financial hit? Not worth all the bother.
SaschaFranck
LocationGermoney
In case it's got the global blocks functionality (which the Helix will likely never will see) from the Axe FX, I might be in one day. Better hardware, better visibility on stage and an iOS editor, too. Hence, many things I'm missing from the Helix.
1 hour ago, SaschaFranck said:
I'll bite… What makes it more visible on stage? The Fractal scribble strips are actually quite a bit smaller than the Helix ones. As far as the iOS editor, that's a third party app, isn't it?
13 hours ago, phil_m said:
What makes it more visible on stage?
Quality LED rings. Compared the FM3 to the Helix already. The display has better readability as well. No idea about the scribble strips (didn't pay attention) but the bad visibility hasn't got anything to do with the size but with the lack of brightness and the rather pointless idea of making the text slightly more bold on active ones rather than inverting everything (which would immensely help already but L6 doesn't give a damn - would be a 5 minute job for any decent programmer).
As far as the iOS editor, that's a third party app, isn't it?
Sure - but it exists. Nothing like it for the Helix. And right now, no programmer outside of Line 6 could even come up with one for the Helix. A touchscreen optimized editor would be dope but L6 doesn't seem to understand that.
18 hours ago, theElevators said:
I think in your position as a gigging player, that is the only way to go, you've obviously got helix set up perfectly for what you're doing. I'm not playing live so it's different for me but you are right, at the end of the day we all have a time investment with helix one way or another
In the UK though, the fractal works out a bit cheaper than a new Helix at the moment. Fractal have obviously targeted the Helix this time around. I think Helix must dominate the market share for floor processors and fractal now want a piece of that
datacommando
Location3rd Stone From The Sun
1 hour ago, Paulzx said:
In the UK though, the fractal works out a bit cheaper than a new Helix at the moment.
From the G66.eu website:
"The price in Europe should be about EUR 1899-1999 (GBP 1599-1699) including VAT and 3-years' warranty."
but remember there is a waiting list, they're not available yet, so maybe the price will change when it hits the streets.
Meanwhile a Helix floor model is available now in the U.K. for £1,149.00.
https://www.peachguitars.com/line-6-helix-floor-tour-grade-guitar-processor.htm?opt=11321
Gear 4 Music are slightly more expensive at £1,299, but they have 4 available in stock now.
https://www.gear4music.com/Guitar-and-Bass/Line-6-Helix/1AFI
Edited August 30, 2021 by datacommando
Added link
Let alone you can always get a Helix in pretty much mint condition used (even with some warranty left, I have seen them selling for around €900 not too long ago). Not at all possible for an FM9 for a very long time to come. Add to this that you'll likely want an expression pedal, too.
Still, looks like a unit that could check many of my boxes - unfortunately, the global block functionality still seems to be something exclusive to to Axe FX. But they may have it added when I'm ready for a new unit (no need to spend any money for a modeler during a pandemic still killing pretty much all gigs for at least another half a year).
12 hours ago, SaschaFranck said:
No idea about the scribble strips (didn't pay attention) but the bad visibility hasn't got anything to do with the size but with the lack of brightness and the rather pointless idea of making the text slightly more bold on active ones rather than inverting everything (which would immensely help already but L6 doesn't give a damn - would be a 5 minute job for any decent programmer).
Right?!? Since they are inverting black/white for the pedalboard mode. If it were my call, I'd also have the same snapshot name view as the Helix LT. To me my signal chain view is absolutely freaking USELESS! I am playing a show, and I don't care about the order of my blocks. So it's just a huge waste of a huge screen to display all these blocks. When playing an outdoor show during daytime, Helix LT has better visibility than the floor. Good thing I have both :) -- LT is my workhorse, practice tool and the Floor is what I take to [dark] gigs. On a dark stage, the scribble strips absolutely saved my lollipop last time -- no way I'd be able to see anything, unless I changed the ring lights setting.
16 minutes ago, theElevators said:
Since they are inverting black/white for the pedalboard mode.
The Helix Floor is also inverting snapshot numbers on the scribble strips- which already helps a *lot* when it comes to visibility, and it's really just the small numbers, not even the text.
If it were my call, I'd also have the same snapshot name view as the Helix LT.
Yeah, but not only that. They could give us a 1:1 representation of what each switch is doing on the screen, regardless of the mode. Just give me 2 rows of 5 equally sized squares, ideally in monochrome coloration for even better visualisation (as soon as something is colored, the display shows it's subpar quality, just try to read, say, some orange colored amp parameter values in sunlight, it's barely possible at all).
And yeah, I apart from some last minute parameter adjustments during soundcheck, I never need any signal flow display, either.
My guess however would be that they won't add that screen mode to the Floor as that'd be like admitting they didn't get the rest of the visibility related things right. Same for inverted scribble strip displays - which would very likely not even take half a day of programming manpower.
cruisinon2
At last! Something new to specu-whine about...;)
On 8/30/2021 at 10:55 AM, datacommando said:
Helix was around £1400 over here when I looked before but either way, they've tried to put it in the same price point as Helix obviously,
as I said before though, it would have to be A LOT better than a Helix to tempt me. Be interesting if someone here can get a demo on one
3 hours ago, Paulzx said:
There's a whole bunch of people over on the Farcebuck Helix Family Group spitting venom about other people posting the demo of this Fractal gizmo in the Helix threads. It's going along the lines of "Burn the Witch"!
Anyhow if you want to hear it - it's no secret - there is an almost 10 minute video on Uchoob, by Brett Kingsman down in Melbourne AU. Search for "Fractal Audio: FM9 Amp Modeler / FX Processor" and you will find it. Also a longer, almost half hour demo from Leon Todd.
I'm not impressed, it's got less footwswitches than the Helix and no built in EX Pedal.
As noted by "cruisinon2" in the post above, - "Something new to specu-whine about...;)"
Hmm... yawn... here we go again.
EDIT: Re pricing. Considering the current state of the world, I would imaging the Fractal "should be about" price will go up. It's got a hundred quid variable in the guesstimate price anyhow.
Hope this helps/makes sense
codamedia
I'm sure it will be a great sounding unit... I'm happy for Fractal on their latest release.
My thoughts, just in case anyone really cares :)
Those so interested in price need to factor in an expression pedal... if that is something you use.
With 3 less "useable" footswitches (than a Helix) it limits the live control. Maybe not for everyone, but it would for me.
Competition is good.... it keeps both Fractal and Line 6 progressing. For that reason, I fully embrace this product even if I don't believe I will ever buy/use one.
Modeling matured over the last decade. IMO, the sounds are already great.... it's now just down to variations and features.
The Amp World and Pedal world are NO DIFFERENT! Everything matured long ago so now it's just variation upon variation with the odd new feature (and sometimes a "killer feature") rolled in.
The Keyboard world went through this by 1990 or shortly after. I think watching that happen in real time has helped me recognize that point has already arrived with modeling.
Some people will not be able to live without the new features, and some will be happy with what they have. Just like some need a Boogie Mark V and a massive pedal board while others are more than happy with a Fender '65 Deluxe with no effects.
It's a great time to be a guitar player.... EMBRACE IT!
Fwiw, I think there's *plenty* of room for improvements in the land of modeling. But less so in terms of sounds (especially regarding the basic amp and pedal sounds we all may want) but mainly in terms of useability.
Unfortunately, Fractal doesn't push that aspect much further - I would actually welcome it a lot if they did, as others would pretty likely try to follow.
For example, what I'd really love to see is a mobile device editor, ideally (and hence obviously) connecting wirelessly. At the moment, only Boss offers that - and it's one of the main reasons why I might get a 2nd hand GT-1000 one day (even if it might end up being sold again). Fracpad is a third party app and from all I know, it requires a cabled connection, plus it's only available for iOS.
Personally, I'd also like to see a device with more knobs and switches (the knobs however could likely be replaced by a mobile editing app). Fractal at least allows you to integrate an additional FC seamlessly, the other competitors don't (and I'm constantly running into a switch limit on the Helix).
I also think that each and every modeler should offer a feature such as global blocks - which would be tremendously useful in a whole number of scenarios. Just as one example regarding the Helix: Instead of slamming lots of things into one patch to achieve seamless switching, one could simply use the seamless patch switching option and distribute the overall DSP load to two patches while still not having to adjust multiple patches (as the important things could be set to be globally adjustable). For me, this would likely work absolutely great for anything I do. It'd possibly also make patch programming a lot easier as you wouldn't have to think about how to distribute things to paths 1 and 2. The resulting patches would offer a better overview, too. Another reason why I'm keeping an eye on the GT-1000 because apart from the Axe FX it's the only other device offering such a functionality.
Another thing that's constantly bothering me with the Helix is the absurdly yesteryear-ish organisation of IRs. Come on, it's 2021 and each computing device (or application) dealing with file storage in one way or the other should have a search function. With the Helix, all you get is some alert that the IR is missing. Yeah, right.
And when it comes to sonic improvements, I'm absolutely wondering why there's still no modeler allowing us to load longer IRs (for reverbs and experimental purposes). I mean, the Logidy EPSI was introduced in 2014 and could already load IRs up to 5 seconds in a box selling for 200 bucks. I can as well load a whole lot of IRs parallely on my 2008 Macbook. And now there's Fractal and Neural DSP coming along, telling us they'd offer the most powerful modeling devices ever, yet IR lengths aren't even covering more than 2048 or 4096 samples at best? In mono?
Oh, and I wish there would be something like an experimental playground, allowing you to, say, construct some new FX by combining a few basic blocks into a "container" (if you will). This is sort of possible in some modular hosts.
Also, in general, the experimental side of things is horrendously lacking. Where's some LFOs, envelopes, input level modifiers and what not? The Axe FX has some of that stuff, the rest of the hardware modeling world however doesn't even seem to know of the existence of any such things. Anyone who ever fiddled around with, say, Guitar Rig, will likely know what kinda crazy things are possible with just a handful of modulators.
I do absolutely agree that for any kind of bog standard amp/pedal sounds of highest quality (as in "good enough to even fool some analog afficionados"), we're already into option paralysis. Personally, I'd be absolutely fine to never play any other amp model but the ones that are in the Helix already ever again. And I guess it's similar for quite some more people.
But as far as some more "adventurous" sounds go, we haven't even seen any serious efforts yet (ok, maybe something like the SY-300/1000). Just have a look at the synth world (and even more so at the plugin world) and you'll instantly know that modeler makers have barely scratched the surface yet.
17 hours ago, codamedia said:
Agree with this really. I always find it a bit odd when people bash the competition in an effort to defend their own loyalty or purchase, when in the case of the Helix,
let's be honest, you need to hit it out of the park to beat that, but it's good to know what the competition is doing.
As others have mentioned, value for money cannot be beaten on the Helix right now and I for one wouldn't even consider changing to a vaguely similar unit just
because it's new. literally the only thing that interests me about Fractal gear, is the quality of the tones it produces. If the FM9 turns out to be vastly better in terms
of the guitar sound it produces, then I want to know about it because as most guitar players, we want the best sounding stuff within a realistic budget.
It's interesting to see how the FM9 goes down once more people have bought it. Initially on some Fractal forums, I've seen conversations where people
were comparing it unfavourably to the Helix! It's just interesting to know that's all.
It could become even more interesting when Helix firmware v.3.2 lands.
Don't know what is in it but over on TGP, Digital Igloo made this comment on Aug 22, 2021
"A few big (and small) things are coming, but they're not what you expect and they're not going to upset any Helix/HX users."
Mmm... D.I. being enigmatic as ever.
Don't ya just luv intriguing comments like that one.
1 hour ago, datacommando said:
"...and they're not going to upset any Helix/HX users."
Oh, I think we've all been hanging around here long enough to know that even if the update came with free $100 bills, once a week for life, plus a backstage pass to the Victoria's Secret fashion show, the Cranky Contingent would still whine that everything on their personal wish list wasn't included...;)
ThisIsFunk
I have Helix LT and an Axe FM3. When I "upgraded" from Amplutube 5 to Helix I was underwhelmed. Don't get me wrong, I love them both they're absolutely awesome, but I felt like the sounds were comparable to AT5 quality. Then I got my FM3 and the first chord I played…. sounded absolutely amazing, so organic. I'll be selling my FM3 soon to get the FM9 (because only three foot switches isn't enough and it's global, not per preset, which was a turn off after I bought it, the FM9 fixes that issue). Helix/Fractal both have their purposes. I still often use my Helix LT though with my Variax, that setup is so incredibly awesome and I love Line6 for that! I think Fractal wins on tones, but Helix wins on versatility and possibilities.
TRENDKILLCFH333
LocationDenver, CO
10 hours ago, ThisIsFunk said:
I agree. I have the Helix Floor and FM3. Helix is more user friendly - FM3 sounds more realistic. I think I'll actually sell both, get the FM9 and await the next Helix model.
On 10/1/2021 at 8:22 AM, ThisIsFunk said:
This is interesting. Looking at the fm9 has actually steered me towards the fm3 for a number of reasons and I do believe the fm3 is a better sounding unit particularly for high gain tones, than the Helix. I'm going to order one and do a direct comparison.
My requirement is a bit different because although I like the versatility of the Helix, it's not more important than the tones and I'm on a mission to get the best high gain tones, I've never been fully happy with the Helix on this front but that's just me, I realise others get what they need out of it.
To further muddy that issue, I've also discovered there are ways to make the Helix sound better and it all comes down to the output device.
Sadly, I had been using Alto TS212 speakers which although recommended at the time, are in fact lollipop for using with helix. Having swapped to smaller yamaha monitor speakers, the Helix has come alive more, so at the moment I'm looking at getting the Helix to sound as good as it can.
Thats a warning to anyone using these alto speakers.. they're great for music play back but not guitar. Way too much bottom end and way too muddy, it kills your tone
15 hours ago, TRENDKILLCFH333 said:I think I'll actually sell both, get the FM9 and await the next Helix model.
That's not a bad idea at all! I just love my Helix with a Variax too much to part with, a match made in heaven.
Yeah, you gotta find what works best for you. I would just say consider two things about the FM3 before buying. I thought three foot switches on the FM3 would be enough if you can control different pedals in different presets in stomp mode, set per preset (programmable like Helix)…. You can't (at least no way I can find)!!!!!! THEY ARE GLOBAL meaning when you set Stomp 1 to "drive 1" in stomp mode it is always drive 1, even if you don't have a drive pedal on that preset… that stomp then becomes useless when in Stomp mode for some presets. With the FM9 many people set it so the top right three stomps jump between presets, stomp mode, and scenes with the bottom six then controlling variables in each each (very similar to Helix setup which is awesome).
Also, FM9 can do two amps. Just one amp on the FM3 absolutely sounds amazing with the quality and is truly enough, but a two amp setup sometimes can work wonders for tone and sound. I find that on the Helix, all of the best preset files I've downloaded from others online all had a two amp setup, with each amp panned hard to the opposite side. I'm looking forward to trying that on theFM9.
Again, everyone has different needs, so the FM3 could be the best for you, just things to consider….. Best of luck on your choosing.
17 hours ago, TRENDKILLCFH333 said:
I think I'll actually sell both, get the FM9 and await the next Helix model.
That could be a very long wait.
Quote from Digital Igloo, over on TGP -
There will be no "Helix 2."
That followed on from his comment regarding firmware updates.
"Well, we didn't spend all that time and energy building Helix Core just to extend the family's life by two or three updates."
22 hours ago, datacommando said:
Interesting to know and to be fair line 6 do pretty well with updates so I think if they find a way of just improving some of the sounds now and then, it would be enough
I expect a lot of folks got the extra foot switch device to use with fm3, I would probably do the same eventually.
I was aware fm9 can do dual amps whereas fm3 can't, obviously Helix can do dual amps or IRs, but it's interesting you say your best downloaded tones were dual amp because I've never found any that I thought were any better than single amp, but I may try this again, can you recommend any?
Registered Products:10
Line6 is pretty damn good avoiding oversaturated markets. They always nailed it.
Now market is really oversatured of "helix'ed" devices (we all have to be honest, after the helix floor success, everyone tried to copy the concept, for the worse or for the better, doesn't matter), so imho they won't be doing a Helix 2, but just inventing something "new", and moving from there.
but I may try this again, can you recommend any?
I wish I could, but I changed the file names after I downloaded them from the forums so I can't remember who's they were, but the ones where I thought those people did better than my setups were Van Halen, Morley Crue etc, they seemed to be much more harmonically rich than what my end products are usually on Helix (although I usually use pretty basic setups and don't do too much tweaking).
On 10/2/2021 at 6:04 AM, datacommando said:
That makes sense. However, I'm sure there will be another flagship processor after Helix.
4 hours ago, TRENDKILLCFH333 said:
However, I'm sure there will be another flagship processor after Helix.
There is always something better further down the line - that's how we got to this stage of digital modelling.
Note: Subsequent to making the "no Helix 2" comment, Digital Igloo also went on to say that he was currently engaged in working on designs for 23 (yes, count 'em, 23) potential products. O.K. Many of those may never see the light of day, but others - well who knows?
It makes perfect sense that one of those could eventually be a potential successor to the current Helix, but as that was originally in development for many, many years I wouldn't hold my breath waiting for it to drop.
glideman
So what year do we see another update for the Helix? LoL!
MGW-Alberta
I run my Helix Floor into a guitar amp using the 4CM.
Am I blind? I don't see any loops on the FM9.


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text:
Q: Is it possible to check if a bucket name already exists? I have a method that needs a name to create a new bucket.
And I want to show a message "bucket name already exist" if the bucket name already exist.
It is possible to check if a bucket name already exists?
def createBucket(bucketName):
    c = boto.s3.connect_to_region("us-east-1")
    # if bucketName exist:
        print "bucket name already exist"
    else:
        bucket = c.create_bucket(bucketName)

bucket = createBucket(raw_input("Bucket name: "))

A: lookup should work (though I can't try now).

A: Amazon Web Services will give you a custom S3CreateError exception when the bucket name per location has already been taken.
>>> bucket = conn.create_bucket('mybucket')
Traceback (most recent call last):
  File "<stdin>", line 1, in ?
  File "boto/connection.py", line 285, in create_bucket
    raise S3CreateError(response.status, response.reason)
boto.exception.S3CreateError: S3Error[409]: Conflict

You could use that exception for your case.
from boto.exception import S3CreateError

    def createBucket(bucketName):
        c = boto.s3.connect_to_region("us-east-1")
        try:
            bucket = c.create_bucket(bucketName)
        except S3CreateError:
            print "bucket name already exist"

    bucket = createBucket(raw_input("Bucket name: "))

A: assumes boto.cfg is configured for region, secure, access, etc.
from boto.s3.connection import S3Connection
conn = S3Connection()
if conn.lookup('bucketnamehere') is not None:
     print('bucket already exists')

if your boto does not support conn.lookup, you may want to use head instead of get (see : http://boto.readthedocs.org/en/latest/ref/s3.html#module-boto.s3.connection )
try:
    conn.head_bucket('bucketnamehere')

except S3ResponseError as error:
    print('bucket already exists: {0}'.format(error))

A: I had the same question but a) using boto3 and b) I care about the difference between "doesn't exist in anyone's account" and "I just don't have access". This is what what I found seems to work:
import boto3
list(s3.Bucket("private").objects.all())
# Thank you whoever created that bucket!
# -> throws "An error occurred (AccessDenied)..."

list(s3.Bucket(some_name_that_does_not_exists).objects.all())
# -> throws "An error occurred (NoSuchBucket)..."

redpajama_set_name: RedPajamaStackExchange


text:
Difference between revisions of "Resistance"
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{{Top}}résistance{{Bottom}}
=====Sigmund Freud=====
[[Freud]] first used the term "[[resistance]]" to designate the unwillingness to [[recall]] [[repressed]] [[memories]] to [[consciousness]].
[[Freud]] first used the term '[[resistance]]' to designate the unwillingness to [[recall]] [[repressed]] [[memories]] to [[consciousness]].
=====Treatment=====
Since [[psychoanalytic treatment]] involves precisely such [[recollection]], the term soon came to denote all those obstacles that arise during the [[treatment]] and interrupt its [[progress]]:
Since [[psychoanalytic treatment]] involves precisely such [[recollection]], the term soon came to denote all those obstacles that arise during the [[treatment]] and interrupt its [[progress]]: "Whatever disturbs the progress of the work isa resistance."<ref>Freud, 1900a: SE V, 517</ref>

"Whatever disturbs the progress of the [[work]] isa resistance."<ref>{{F}} ''[[Works of Sigmund Freud|The Interpretation of Dreams]]'', 1900a. [[SE]] IV-V, 517</ref>

[[Resistance]] manifests itself in all the ways in which the [[subject]] breaks the '[[fundamental rule]]' of saying everything that comes into his mind.
[[Resistance]] manifests itself in all the ways in which the [[subject]] breaks the "[[fundamental rule]]" of saying everything that comes into his [[mind]].
=====Psychoanalytic Theory=====
Though [[present]] in [[Freud]]'s work from the beginning, the [[concept]] of [[resistance]] began to play an increasingly important part in [[psychoanalytic theory]] as a result of the decreasing efficacy of [[analytic treatment]] in the decade 1910-20.
Though present in [[Freud]]'s work from the beginning, the concept of [[resistance]] began to play an increasingly important part in [[psychoanalytic theory]] as a result of the decreasing efficacy of [[analytic treatment]] in the decade 1910-20.
As a consequence of this, [[ego-psychology]] placed increasing importance on overcoming the [[patient]]'s [[resistance]]s.
==Jacques Lacan==
=====Lacan's Criticism=====
[[Lacan]] is very critical of this shift in emphasis, arguing that it easily leads to an 'inquisitorial' style of psychoanalysis which sees resistance as based on the 'fundamental ill will' of the patient.<ref>{{S1}} p.30</ref>
[[Lacan]] is very critical of this shift in emphasis, arguing that it easily leads to an "inquisitorial" style of [[psychoanalysis]] which sees [[resistance]] as based on the "fundamental ill will" of the patient.<ref>{{S1}} p. 30</ref>
[[Lacan]] argues that this overlooks the structural nature of
[[Lacan]] argues that this overlooks the structural [[nature]] of
resistatice and reduces analysis to an imaginary dual relation <ref>{{E}} p.78; {{Ec}} p.333ff</ref>
[[resistance]] and reduces analysis to an [[imaginary]] [[dual relation]].<ref>{{E}} p. 78; {{Ec}} p. 333ff</ref>
[[Lacan]] does accept that [[psychoanalytic treatment]] involves "analysis of resistances," but only on condition that this phrase is understood correctly, in the sense of "knowing at what level the answer should be pitched."<ref>{{S2}} p.43</ref>
[[Lacan]] does accept that [[psychoanalytic treatment]] involves "analysis of resistances," but only on condition that this phrase is [[understood]] correctly, in the [[sense]] of "[[knowing]] at what level the answer should be pitched."<ref>{{S2}} p. 43</ref>
In other words, the crucial thing is that the [[analyst]] should be able to distinguish between interventions that are primarily orientated towards the [[imaginary]] and those that are orientated towards the [[symbolic]], and know which are appropriate at each moment of the [[treatment]].
In other [[words]], the crucial [[thing]] is that the [[analyst]] should be able to distinguish between interventions that are primarily orientated towards the [[imaginary]] and those that are orientated towards the [[symbolic]], and [[know]] which are appropriate at each [[moment]] of the [[treatment]].
=====Structural Resistance=====
In [[Lacan]]'s view, [[resistance]] is not a question of the ill will of the [[analysand]]; [[resistance]] is [[structural]], and it is inherent in the [[analytic process]].
This is due, ultimately, to a [[structural]] "incompatibility between desire and speech."<ref>{{E}} p.275</ref>
This is due, ultimately, to a [[structural]] "incompatibility between desire and speech."<ref>{{E}} p. 275</ref>
Therefore there is a certain irreducible level of [[resistance]] which can never be 'overcome'.
Therefore there is a certain irreducible level of [[resistance]] which can never be "overcome".
"After the reduction of the [[resistance]]s, there is a residue which may be what is essential."<ref>{{S2}} p.321</ref>

"After the reduction of the [[resistance]]s, there is a residue which may be what is essential."<ref>{{S2}} p.321</ref>

This irreducible 'residue' of [[resistance]] is 'essential' because it is the respect for this residue that distinguishes psychoanalysis from [[suggestion]].
=====Suggestion=====
This irreducible "residue" of [[resistance]] is "essential" because it is the respect for this residue that distinguishes [[psychoanalysis]] from [[suggestion]].
[[Psychoanalysis]] respects the right of the [[patient]] to resist [[suggestion]] and indeed values that [[resistance]].
[[Psychoanalysis]] respects the [[right]] of the [[patient]] to resist [[suggestion]] and indeed values that [[resistance]].

"When the [[subject]]'s [[resistance]] opposes [[suggestion]], it is only a [[desire]] to maintain the [[subject]]'s [[desire]]. As such it would have to be placed in the ranks of positive [[transference]]."<ref>{{E}} p.271</ref>

=====Analyst and Analysand=====
However, [[Lacan]] points out that while the [[analyst]] cannot, and should not try to, overcome all [[resistance]], he can minimise it, or at least avoid exacerbating it.<ref>{{S2}} p. 228</ref>
However, [[Lacan]] points out that while the [[analyst]] cannot, and should not try to, overcome all [[resistance]], he can minimise it, or at least avoid exacerbating it.<ref>{{S2}} p.228</ref>
He can do this by recognizing his own part in the [[analysand]]'s [[resistance]], for "there is no other [[resistance]] to [[analysis]] than that of the [[analyst]] himself."<ref>{{E}} p. 235</ref>
He can do this by recognising his own part in the [[analysand]]'s [[resistance]], for "there is no other [[resistance]] to [[analysis]] than that of the [[analyst]] himself."<ref>{{E}} p.235</ref>
This is to be understood in two ways:
==One==
=====Lure=====
The [[resistance]] of the [[analysand]] can only succeed in obstructing the [[treatment]] when it responds to and/or evokes a [[resistance]] on the part of the [[analyst]], i.e. when the [[analyst]] is drawn into the [[lure]] of [[resistance]] (as [[Freud]] was drawn into the [[lure]] of [[Dora]]'s [[resistance]]).
"The patient's resistance is always your own, and when a resistance succeeds it is because you [the analyst] are in it up to your neck, because you understand."<ref>{{S3}} p.48</ref>

"The patient's resistance is always your own, and when a resistance succeeds it is because you [the analyst] are in it up to your neck, because you [[understand]]."<ref>{{S3}} p.48</ref>

Thus the [[analyst]] must follow the rule of neutrality and not be drawn into the [[lures]] set for him by the [[patient]].
Thus the [[analyst]] must follow the rule of [[neutrality]] and not be drawn into the [[lures]] set for him by the [[patient]].
==Two==
=====Interpretation=====
It is the [[analyst]] who provokes [[resistance]] by pushing the [[analysand]]:
"There is no resistance on the part of the subject."<ref>{{S2}} p.228</ref>

"There is no resistance on the part of the subject."<ref>{{S2}} p.228</ref>

"[[Resistance]] is the present state of an [[interpretation]] of the [[subject]]. It is the manner in which, at the same time, the subject interprets the point he's got to. ... It simply means that he [the patient] cannot move any faster."<ref>{{S2}} p.228</ref>

"[[Resistance]] is the present [[state]] of an [[interpretation]] of the [[subject]]. It is the manner in which, at the same [[time]], the subject interprets the point he's got to. ... It simply means that he [the patient] cannot move any faster."<ref>{{S2}} p.228</ref>

[[Psychoanalytic treatment]] works on the principle that by not forcing the [[patient]], [[resistance]] is reduced to the irreducible minimum.
[[Psychoanalytic treatment]] works on the [[principle]] that by not forcing the [[patient]], [[resistance]] is reduced to the irreducible minimum.
Thus the [[analyst]] must avoid all forms of [[suggestion]].
=====Ego=====
The source of [[resistance]] lies in the [[ego]]:
"In the strict sense, the [[subject]]'s [[resistance]] is linked to the [[register]] of the [[ego]], it is an effect of the [[ego]]."<ref>{{S2}} p.127</ref>

"In the strict sense, the [[subject]]'s [[resistance]] is linked to the [[register]] of the [[ego]], it is an effect of the [[ego]]."<ref>{{S2}} p.127</ref>

=====Imaginary Order=====
Thus [[resistance]] belongs to the [[imaginary]] [[order]], not to the level of the [[subject]].
"On the side of what is [[repressed]], on the [[unconscious]] side of things, there is no [[resistance]], there is only a tendency to [[repeat]]."<ref>{{S2}} p.321</ref>

"On the side of what is [[repressed]], on the [[unconscious]] side of things, there is no [[resistance]], there is only a tendency to [[repeat]]."<ref>{{S2}} p.321</ref>

This is illustrated in [[schema L]]; resistance is the imaginary axis a-a' which impedes the insistant speech of the Other (which is the axis A-S).
This is illustrated in [[schema L]]; [[resistance]] is the [[imaginary]] axis '''a-a'''' which impedes the insistant [[speech]] of the [[Other]] (which is the axis ''A-S'').
The [[resistance]]s of the [[ego]] are [[imaginary]] [[lures]], which the [[analyst]] must be wary of being [[deceived]] by.<ref>{{E}} p.168</ref>
The [[resistance]]s of the [[ego]] are [[imaginary]] [[lures]], which the [[analyst]] must be wary of [[being]] [[deceived]] by.<ref>{{E}} p. 168</ref>
Thus it can never be the [[aim]] of [[analysis]] to "strengthen the [[ego]]," as [[ego-psychology]] claims, since this would only serve to increase [[resistance]].
=====Ego-psychology=====
=====Resistance and Defence=====
[[Lacan]] also criticises [[ego-psychology]] for confusing the concept of [[resistance]] with that of [[defense]].
[[Lacan]] also criticizes [[ego-psychology]] for confusing the concept of [[resistance]] with that of [[defense]].
However, the distinction which [[Lacan]] draws between these two concepts is rather different from the way in which they are distinguished in Anglo-American [[psychoanalysis]].
However, the [[distinction]] which [[Lacan]] draws between these two [[concepts]] is rather different from the way in which they are distinguished in Anglo-American [[psychoanalysis]].
[[Lacan]] argues that [[defence]] is on the side of the [[subject]], whereas [[resistance]] is on the side of the [[object]].
That is, whereas [[defence]]s are relatively stable [[symbolic]] [[structure]]s of [[subjectivity]], [[resistance]]s are more transitory forces which prevent the [[object]] from being absorbed in the [[signifying chain]].
That is, whereas [[defence]]s are relatively [[stable]] [[symbolic]] [[structure]]s of [[subjectivity]], [[resistance]]s are more transitory forces which prevent the [[object]] from being absorbed in the [[signifying chain]].
{{See}}
* [[Analysand]]
* [[Defence]]
* [[Ego]]
* [[Ego-psychology]]
* [[Lure]]
* [[Psychoanalysis]]
* [[Repression]]
* [[Structure]]
* [[Subject]]
* [[Suggestion]]
* [[Treatment]]
* [[Unconscious]]
{{Also}}
==References==

[[Category:New]]
[[Category:Jacques Lacan]]
[[Category:Terms]]
[[Category:Concepts]]
[[Category:Dictionary]]
[[Category:Treatment]]
[[Category:Practice]]
[[Category:Imaginary]]
[[Category:Psychoanalysis]]
French: résistance
Freud first used the term "resistance" to designate the unwillingness to recall repressed memories to consciousness.
Since psychoanalytic treatment involves precisely such recollection, the term soon came to denote all those obstacles that arise during the treatment and interrupt its progress:
"Whatever disturbs the progress of the work isa resistance."[1]
Resistance manifests itself in all the ways in which the subject breaks the "fundamental rule" of saying everything that comes into his mind.
Though present in Freud's work from the beginning, the concept of resistance began to play an increasingly important part in psychoanalytic theory as a result of the decreasing efficacy of analytic treatment in the decade 1910-20.
As a consequence of this, ego-psychology placed increasing importance on overcoming the patient's resistances.
Lacan's Criticism
Lacan is very critical of this shift in emphasis, arguing that it easily leads to an "inquisitorial" style of psychoanalysis which sees resistance as based on the "fundamental ill will" of the patient.[2]
Lacan argues that this overlooks the structural nature of resistance and reduces analysis to an imaginary dual relation.[3]
Lacan does accept that psychoanalytic treatment involves "analysis of resistances," but only on condition that this phrase is understood correctly, in the sense of "knowing at what level the answer should be pitched."[4]
In other words, the crucial thing is that the analyst should be able to distinguish between interventions that are primarily orientated towards the imaginary and those that are orientated towards the symbolic, and know which are appropriate at each moment of the treatment.
Structural Resistance
In Lacan's view, resistance is not a question of the ill will of the analysand; resistance is structural, and it is inherent in the analytic process.
This is due, ultimately, to a structural "incompatibility between desire and speech."[5]
Therefore there is a certain irreducible level of resistance which can never be "overcome".
"After the reduction of the resistances, there is a residue which may be what is essential."[6]
This irreducible "residue" of resistance is "essential" because it is the respect for this residue that distinguishes psychoanalysis from suggestion.
Psychoanalysis respects the right of the patient to resist suggestion and indeed values that resistance.
"When the subject's resistance opposes suggestion, it is only a desire to maintain the subject's desire. As such it would have to be placed in the ranks of positive transference."[7]
Analyst and Analysand
However, Lacan points out that while the analyst cannot, and should not try to, overcome all resistance, he can minimise it, or at least avoid exacerbating it.[8]
He can do this by recognizing his own part in the analysand's resistance, for "there is no other resistance to analysis than that of the analyst himself."[9]
The resistance of the analysand can only succeed in obstructing the treatment when it responds to and/or evokes a resistance on the part of the analyst, i.e. when the analyst is drawn into the lure of resistance (as Freud was drawn into the lure of Dora's resistance).
"The patient's resistance is always your own, and when a resistance succeeds it is because you [the analyst] are in it up to your neck, because you understand."[10]
Thus the analyst must follow the rule of neutrality and not be drawn into the lures set for him by the patient.
It is the analyst who provokes resistance by pushing the analysand:
"There is no resistance on the part of the subject."[11]
"Resistance is the present state of an interpretation of the subject. It is the manner in which, at the same time, the subject interprets the point he's got to. ... It simply means that he [the patient] cannot move any faster."[12]
Psychoanalytic treatment works on the principle that by not forcing the patient, resistance is reduced to the irreducible minimum.
Thus the analyst must avoid all forms of suggestion.
The source of resistance lies in the ego:
"In the strict sense, the subject's resistance is linked to the register of the ego, it is an effect of the ego."[13]
Imaginary Order
Thus resistance belongs to the imaginary order, not to the level of the subject.
"On the side of what is repressed, on the unconscious side of things, there is no resistance, there is only a tendency to repeat."[14]
This is illustrated in schema L; resistance is the imaginary axis a-a' which impedes the insistant speech of the Other (which is the axis A-S).
The resistances of the ego are imaginary lures, which the analyst must be wary of being deceived by.[15]
Thus it can never be the aim of analysis to "strengthen the ego," as ego-psychology claims, since this would only serve to increase resistance.
Ego-psychology
Resistance and Defence
Lacan also criticizes ego-psychology for confusing the concept of resistance with that of defense.
However, the distinction which Lacan draws between these two concepts is rather different from the way in which they are distinguished in Anglo-American psychoanalysis.
Lacan argues that defence is on the side of the subject, whereas resistance is on the side of the object.
That is, whereas defences are relatively stable symbolic structures of subjectivity, resistances are more transitory forces which prevent the object from being absorbed in the signifying chain.
Analysand
Unconscious
↑ Freud, Sigmund. The Interpretation of Dreams, 1900a. SE IV-V, 517
↑ Lacan, Jacques. The Seminar. Book I. Freud's Papers on Technique, 1953-54. Trans. John Forrester. New York: Nortion; Cambridge: Cambridge University Press, 1988. p. 30
↑ Lacan, Jacques. Écrits: A Selection. Trans. Alan Sheridan. London: Tavistock Publications, 1977. p. 78; Lacan, Jacques. Écrits. Paris: Seuil, 1966. p. 333ff
↑ Lacan, Jacques. The Seminar. Book II. The Ego in Freud's Theory and in the Technique of Psychoanalysis, 1954-55. Trans. Sylvana Tomaselli. New York: Nortion; Cambridge: Cambridge Unviersity Press, 1988. p. 43
↑ Lacan, Jacques. Écrits: A Selection. Trans. Alan Sheridan. London: Tavistock Publications, 1977. p. 275
↑ Lacan, Jacques. The Seminar. Book II. The Ego in Freud's Theory and in the Technique of Psychoanalysis, 1954-55. Trans. Sylvana Tomaselli. New York: Nortion; Cambridge: Cambridge Unviersity Press, 1988. p.321
↑ Lacan, Jacques. Écrits: A Selection. Trans. Alan Sheridan. London: Tavistock Publications, 1977. p.271
↑ Lacan, Jacques. The Seminar. Book II. The Ego in Freud's Theory and in the Technique of Psychoanalysis, 1954-55. Trans. Sylvana Tomaselli. New York: Nortion; Cambridge: Cambridge Unviersity Press, 1988. p. 228
↑ Lacan, Jacques. The Seminar. Book III. The Psychoses, 1955-56. Trans. Russell Grigg. London: Routledge, 1993. p.48
Retrieved from "https://nosubject.com/index.php?title=Resistance&oldid=44820"


text:
Q: The correct way to normalize time series data A question very similar to mine has been asked already:
Zero mean unit variance normalization of multivariate time series
I'm asking a new question because that one didn't have any replies.
I'm analyzing dataset number 6 here
https://ti.arc.nasa.gov/tech/dash/groups/pcoe/prognostic-data-repository/
in particular, data set 001.
Data: The data set consists of multiple multivariate time series. Each time series is from a different engine – i.e., the data can be considered to be from a fleet of engines of the same type. For each engine, we have the engine ID, the time of operation (in cycles), and 24 time series: three operating conditions and 21 noisy sensor measurements. Example:
> glimpse(train_set)
Observations: 20,631
Variables: 26
$ engine       <int> 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1...
$ cycles       <int> 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14,...
$ op_setting_1 <dbl> -0.0007, 0.0019, -0.0043, 0.0007, -0.0019, -0....
$ op_setting_2 <dbl> -4e-04, -3e-04, 3e-04, 0e+00, -2e-04, -1e-04, ...
$ op_setting_3 <dbl> 100, 100, 100, 100, 100, 100, 100, 100, 100, 1...
$ sensor_1     <dbl> 518.67, 518.67, 518.67, 518.67, 518.67, 518.67...
$ sensor_2     <dbl> 641.82, 642.15, 642.35, 642.35, 642.37, 642.10...
$ sensor_3     <dbl> 1589.70, 1591.82, 1587.99, 1582.79, 1582.85, 1...
$ sensor_4     <dbl> 1400.60, 1403.14, 1404.20, 1401.87, 1406.22, 1...
$ sensor_5     <dbl> 14.62, 14.62, 14.62, 14.62, 14.62, 14.62, 14.6...
$ sensor_6     <dbl> 21.61, 21.61, 21.61, 21.61, 21.61, 21.61, 21.6...
$ sensor_7     <dbl> 554.36, 553.75, 554.26, 554.45, 554.00, 554.67...
$ sensor_8     <dbl> 2388.06, 2388.04, 2388.08, 2388.11, 2388.06, 2...
$ sensor_9     <dbl> 9046.19, 9044.07, 9052.94, 9049.48, 9055.15, 9...
$ sensor_10    <dbl> 1.3, 1.3, 1.3, 1.3, 1.3, 1.3, 1.3, 1.3, 1.3, 1...
$ sensor_11    <dbl> 47.47, 47.49, 47.27, 47.13, 47.28, 47.16, 47.3...
$ sensor_12    <dbl> 521.66, 522.28, 522.42, 522.86, 522.19, 521.68...
$ sensor_13    <dbl> 2388.02, 2388.07, 2388.03, 2388.08, 2388.04, 2...
$ sensor_14    <dbl> 8138.62, 8131.49, 8133.23, 8133.83, 8133.80, 8...
$ sensor_15    <dbl> 8.4195, 8.4318, 8.4178, 8.3682, 8.4294, 8.4108...
$ sensor_16    <dbl> 0.03, 0.03, 0.03, 0.03, 0.03, 0.03, 0.03, 0.03...
$ sensor_17    <int> 392, 392, 390, 392, 393, 391, 392, 391, 392, 3...
$ sensor_18    <int> 2388, 2388, 2388, 2388, 2388, 2388, 2388, 2388...
$ sensor_19    <dbl> 100, 100, 100, 100, 100, 100, 100, 100, 100, 1...
$ sensor_20    <dbl> 39.06, 39.00, 38.95, 38.88, 38.90, 38.98, 39.1...
$ sensor_21    <dbl> 23.4190, 23.4236, 23.3442, 23.3739, 23.4044, 2...

There are $N=100$ engines (multivariate time series) in the training set, and each time series has about $M=200$ time samples, so for each sensor we have a total of about  $N\times M = 20000 $ time samples across all engines in the training set. I can add a plot of the data if necessary, but I don't think it's needed for my question.
The engine is operating normally at the start of each time series, and develops a fault at some point during the series. In the training set, the fault grows in magnitude until system failure. In the test set, the time series ends some time prior to system failure.
Analysis goal: Given a test time series as input, I want to predict the corresponding Remaining Useful Life (RUL) value, with a model which I'll train on the training set. I also have a vector of RULs for all time series in the test set, so I can compute the test accuracy of my model. I've chosen to use two models:

*

*Cox proportional hazard models, corrected to allow time-dependent input features (any suggestions/references on how to do this?)

*an RNN

and compare results.
Question: I would like to normalize the value of the sensor outputs, because I don't think the units of measurement carry any information about the RUL.  What's the most correct approach?

*

*for sensor $X_i(t)$, compute the sample mean $\overline{X}_i$ and the sample standard deviation $S$ across all the $\approx 20000$ data points in all time series in the the training set. For example, for sensor_11 we have
summary(train_set$sensor_11)
Min. 1st Qu.  Median    Mean 3rd Qu.    Max.
46.85   47.35   47.51   47.54   47.70   48.53

Then we compute $Z_i(t)=\frac{X_i(t)-\overline{X}_i}{S}$

*or instead we compute the sample mean $\overline{X_i}(t)$ and sample standard deviation $S(t)$ of $X_i(t)$ at each time $t$, and we normalize the time series with a time-varying sample mean and sample standard deviation, $Z_i(t)=\frac{X_i(t)-\overline{X_i}(t)}{S(t)}$. Since I have $N=100$ engines in the training set, at each time $t$ I have a random sample of size $N_t \leq N$ to estimate $\overline{X_i}(t)$ and $S(t)$. I don't overly like this approach because it introduces new issues: if $t_{min}$ is the minimum failure time across all engines in the training set, how do I compute $\overline{X_i}(t)$ and $S(t)$ for times $t>t_{min}$?
Finally, in both cases I believe I should compute $\overline{X}_i$ and $S$ (or  $\overline{X_i}(t)$ and $S(t)$) based only on training set data, and use the values so computed to normalize the test set time series. Correct?
Note that one of the models I'll use is a RNN. I'm not sure if this carries any relevance when choosing the way to normalize data.

A: *

*You should stick to the first approach. Or its variation when you calculate the separate scale for each series. That's a short answer, there are nuances though.

Your scale must be constant if your model doesn't have a scale in it. For instance, take a look at Heston model in finance. Just look at the equations, ignore the context. You see how the valatility changes with time. The first equation models the returns, and the second one models the volatility (standard deviation). The model explicitly models volatility.
In this case I could see dynamic scaling working, because then you'd have other parts of your model that are modeling the scale itself. Your model doesn't have to be stochastic volatility like Heston's but it must explicitly account for the fact that volatility changes over time somehow. Otherwise, if your scale changes and you don't deal with it, I doubt you'll get a sensible result.

*On the second question of whether to use the training set to scale. Ideally it shouldn't even matter, because your scale is constant, right? So, if it's constant then your scale shouldn't change if you calculated it on subsamples. In reality it will move a little bit, and if the change causes issues it means that your training set is different from the test set. The macro characteristics such as means and standard deviation should not change too much between subsamples. If this happens it's a sampling or data size problem. Also, if the change in scale is small, but the model breaks down it means that the model is not robust to small disturbances, a problem in and of itself, in my opinion.


If you're still a little peeved that you couldn't get a ticket to Glastonbury then without doubt the next best festival of similar tone but smaller stature is Latitude Festival. Set in Suffolk's beautiful Henham Park and filled with amicable music lovers of ages zero to 90, it really is a music festival for those who like to chill out as well as rock out. No, we can't believe we said that either.
Anyway, more bands have been added to the bill and they are Glasvegas, Seasick Steve, Iron & Wine and Dog Is Dead. Latitude Festival takes place on the weekend of 15th-17th July and tickets and further information are available from Latitudefestival.co.uk.


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Home > Linguistics, Communication > Vol 6 No 1 June 2018 Abstract 5
A Review of the Critical Period Hypothesis in Second Language Acquisition
Qiao'er Li
The issue about the Critical Period Hypothesis in the first and second language acquisition has been on dispute since the notion of the critical period in biology was proposed. In this paper, We make a review of the studies supporting and opposing the existence of a critical period in second language acquisition from the perspectives of psycholinguistics, cognitive linguistics and neurolinguistics in different language aspects. We concluded that no consensus on this controversial issue was found, because of the different research methods, materials, participants in different studies and the discrepant measurement standards and understanding of scholars about the critical period in language acquisition. We also suggested significant implications of the research findings for second language teaching, and made some recommendations for the future research on age effect upon second language acquisition in China.


Enjoy shopping, museums, parks, and hot springs!
Check out the Sky Garden, an observation deck on the 69th floor!
A beautiful pier with a beautiful design!
Go aboard this ocean liner that is permanently anchored in Yokohama.
Check out one of Kanagawa`s biggest summer event at Minato Mirai.
Enjoy the open green space in Yamashita Park.
One of Japan`s newest zoos.
Check out this awesome museum and learn about the history of ramen.
The shopping streets of the motomachi area are a perfect place to shop.
Make your own cup noodle at Nissin`s Cup Noodle Museum.
Enjoy a theme park, aquarium, shopping area, restaurants, and a hotel, all in the wonderful Hakkejima Sea Paradise.
Tokyo City . Yokohama City, Japan Filmed with DJI Mavic Pro during Summer holiday trip.


Mohamed Salah's double helped Liverpool extend their unbeaten run to 15 games in all competitions with victory against Leicester at Anfield.
Jamie Vardy gave the visitors an early lead when he poked home a Riyad Mahrez pass across the box before Salah equalised in the second half.
The Egypt international then turned Harry Maguire on the edge of the area before firing in his second of the day - and 17th Premier League goal of the season - to give Liverpool the lead.
Jurgen Klopp's Reds will finish the year in fourth place. Leicester remain in eighth but have now gone six games without a win.
Liverpool have failed to capitalise on their chances too many times this season - having to settle for draws against both West Brom and Spartak Moscow after dominating for 90 minutes.
That was not the case on Saturday as the Reds battled through a tough defensive unit to come back from a goal down against the 2016 Premier League champions.
There were still plenty of missed opportunities - Salah squandered four efforts in the first half alone, before Liverpool's top scorer made up for it with two clinical finishes after the break.
It still took 17 shots, six on target, for the hosts to get the result they needed but the recovery from falling behind so early is an encouraging sign for Klopp's side as they head into the new year.
At the other end, it was a fairly solid performance from centre-back duo Dejan Lovren and Joel Matip, who have both been criticised for their performances at times this season.
Overall, Klopp has much to be pleased about after his team produced a persistent display against the Foxes, who have so far been something of a bogey side for the German manager.
Before Saturday's victory, the Reds had lost three times against Leicester under Klopp - more than they have to any other club since he took over in October 2015.
Leicester went into half-time with the lead thanks to yet another goal from Vardy - his 10th of the season.
His record against Liverpool is impressive - scoring seven of Leicester's past nine goals against the Reds in the Premier League.
It was no surprise to see him identified as a threat before the game and he was just that - running in behind the defenders and looking to find spaces behind Liverpool's back four.
There were signs of danger for the home side when Vardy found space on the left even before his third-minute opener.
He could have doubled Leicester's lead shortly before half-time too but for a heavy touch which allowed Lovren time to recover.
Even after Salah's equaliser, England striker Vardy continued to be a constant threat, with the offside flag coming to Liverpool's aid on more than one occasion.
It was therefore a surprise to see him substituted with the teams level - alongside Mahrez, who had assisted Vardy's early goal.
The pair have scored in five of the Foxes' seven games this month and fans will no doubt question Claude Puel's decision to take both of them off with more than 15 minutes still left to play.


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China's Crackdown On On Moderate Voices Has Reached A New Level
Sui-Lee Wee and Megha Rajagopalan,
Oct. 13, 2014, 6:32 AM
To go with story CHINA-DISSIDENT/
BEIJING (Reuters) - China has detained a prominent scholar who helped blind dissident Chen Guangcheng flee to the United States two years ago and has banned books by eight writers in an escalating crackdown on dissent.
Guo Yushan, a founder of the Transition Institute, a think-tank that researches business regulations, reform and civil society, was detained on Thursday, his wife, Pan Haixia, said.
More than 10 police officers took him away along with his laptop, wireless router, mobile phone and iPad, she said.
Guo was instrumental in helping Chen escape house arrest in his village in 2012. Chen traveled to Beijing where he sought refuge at the U.S. embassy, sparking a diplomatic row between China and the United States. Authorities shut down Guo's institute last year.
In a telephone interview, Pan said Guo's detention could be related to the detention of Shi Lin.
Activists describe Shi as an art editor at Peking University and say she was detained after she tried to put up posters on campus expressing support for pro-democracy demonstrations in Hong Kong. In a picture on her Twitter account, she can be seen wearing a face mask with a yellow ribbon on it. The ribbon is a symbol of the protests.
Guo was detained on a charge of "causing a disturbance", according to Pan and his lawyer, Li Jin. Police did not give Pan a reason for Guo's detention. Li said she had applied to meet him but had not heard whether she could.
"We just want to know the truth," Pan said. "We hope the police will investigate this thoroughly and release him quickly."
Police could not be reached for comment.
If charged and convicted, Guo could face up to five years in prison.
'SUSPICIOUS'
China's President Xi Jinping arrives for a meeting with Brazil's President Dilma Rousseff at the Planalto Presidential Palace, in Brasilia, Brazil, Thursday, July 17, 2014.
Felipe Dana/AP
The government has convicted and detained several scholars in what activists say is a sustained campaign against dissent. A court in the western region of Xinjiang sentenced economics professor Ilham Tohti to life on separatism charges last month.
Legal scholar Xu Zhiyong was sentenced in January to four years in prison after he campaigned for government officials to disclose their wealth.
Rights groups say dozens of activists supporting the demonstrations in Hong Kong have been detained or intimidated by police.
Maya Wang of New York-based Human Rights Watch said the detentions signaled increasing intolerance of dissent.
"Even very moderate intellectuals who have kept a low profile ... are now being targeted for detentions," Wang said.
Separately, the State Administration for Press, Publication, Radio, Film and Television said on Friday it was banning books by at least eight renowned writers and intellectuals.
The publishing regulator circulated a notice to say that books by the writers, including prominent liberal economist Mao Yushi, were "not to published", according to the notice, obtained by Reuters.
"A national government organ is daring to risk universal condemnation, in open opposition to the constitution," Mao wrote on his microblog. "What is our government actually trying to do? It makes one suspicious."
The other writers whose books were banned include Zhang Qianfan, a constitutional law expert at Peking University and a critic of the Communist Party's grip on the judiciary. Zhang did not answer calls to his mobile phone.
Books by history scholar Yu Yingshi, Taiwan writer Giddens Ko, Hong Kong television personality Leung Man-tao and columnist Xu Zhiyuan were also banned, according to the regulator. It did not say why and did not respond to a faxed query by Reuters.
It also called for authorities to "strictly" control publication of religious books, especially on Tibetan Buddhism, Christianity and Islam.
The Global Times, a nationalist tabloid owned by the party's official newspaper, the People's Daily, said the ban was justified because some on the list had supported "Hong Kong's Occupy Central movement or 'Taiwan independence'," or they opposed China's political system.
"If one has positioned himself at odds to the country's mainstream political path, he shouldn't expect his influence to keep on rising without disruption," the newspaper said.
(Editing by Robert Birsel)
More: China Censorship Reuters Reuters World


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Zac Efron, Martin Shkreli, Nancy Pelosi, the Sussex Royals, Kamala Harris, Michael Bloomberg, Adam Schiff's Nicknames, Sam Smith: HOT LINKS
JARED KUSHNER. Trump's son-in-law shrugs off questions about his security clearance, and the Mueller Report: "We've had a lot of crazy accusations, like, that we colluded with Russia. I complied with all the different investigations, whether it be the Senate, the House, the special counsel. I've sat for nearly 20 hours of interviews with them."
SPICE DRAMA. Ginger said she never hooked up with Scary.
TAKEDOWN OF THE DAY. Colbert on Trump's threat to close the border.
Rep. Justin Amash (R-MI)
JUSTIN AMASH. Michigan Republican ponders third party run against Trump: "I think my message does resonate with a lot of people," said Amash, now in his fifth Congressional term. "There are people who are tired of the way it works and are coming to understand that the problem is this two-party duopoly and the partisan fighting that is nonstop. If people came to Washington with strong ideologies but less partisanship this would be a lot better."
JOIN THE STRAIGHT ARM CLUB. Pelosi chastises Biden for being too touchy-feely with women: "Just pretend you have a cold and I have a cold."
MAN CANDY. This Karamo Brown #TBT and more here.
It's a #TBT but not much has changed. #CheckMyStoryToSee
A post shared by Karamo (@karamo) on Mar 28, 2019 at 5:46pm PDT
PAPARAZZI. Alexander Skarsgard speaks out about shooting the classic Lady Gaga video.
NEW INSTAGRAM ACCOUNT OF THE DAY. Prince Harry and Meghan Markle.
"Welcome to our official Instagram; we look forward to sharing the work that drives us, the causes we support, important announcements, and the opportunity to shine a light on key issues. We thank you for your support, and welcome you to @sussexroyal."- Harry & Meghan
A post shared by The Duke and Duchess of Sussex (@sussexroyal) on Apr 2, 2019 at 7:16am PDT
2020. Bloomberg might still run: "These people tell me that Bloomberg, 77, who announced March 5 that he wouldn't run, might reconsider if a centrist lane were to open up. The most likely scenario for that would be if Biden, 76, whose displays of public affection have burst into a major issue, were to stay out or fade fast."
THE MATRIARCH. Barbara Bush biography reveals how much Nancy Reagan hated her.
CASH HAUL. Kamala Harris raises $12 million in first quarter: 'Half of the total haul for Harris, a California senator, was raised online, including more than $1.1 million in the final week of March, when she spent heavily to attract more donors ahead of the financial deadline. Harris' overall average donation was $55, while her campaign said the average online contribution was $28.' Bernie Sanders raises $18 million. "Aides said the Vermont senator's average donation was $20. Sanders' campaign said he received a little under 900,000 individual donations, after setting a goal of 1 million in the first quarter of the year."
ADAM SCHIFF. On Trump's nicknames for him: "This is nothing new. We've seen these childish nicknames for a year and a half, but he is violating the cardinal rule of childish nicknames which is you've got to pick one and stick with it.
Question: "What do you make of [Trump] calling you 'Shifty Schiff'?"@RepAdamSchiff: "This is nothing new, we've seen these childish nicknames for a year and a half, but he is violating the cardinal rule of childish nicknames which is you've got to pick one and stick with it." pic.twitter.com/a7DdKjQULM
— The Hill (@thehill) April 2, 2019
TOP TEN OF THE DAY. Earners on YouTube.
BEHIND BARS. Pharmadouche Martin Shkreli placed in solitary confinement: "Earlier this month, the much-maligned pharmaceutical businessman and uber troll Martin Shkreli was put in solitary confinement at Federal Correctional Institution in Fort Dix, New Jersey, Forbes has been told by two sources with knowledge of the situation. That came after the Wall Street Journal described how he was using a contraband phone to run his pharma business from behind bars."
TRAILER OF THE DAY. Pet Sematary.
TRAILER II OF THE DAY. Zac Efron as Ted Bundy in Extremely Wicked, Shockingly Evil and Vile.
SELF-LOVING SELFIE OF THE DAY. Sam Smith
Feeling bloated and gross after my flight so thought I'd post a mirror selfie of my sexy bloated boobies coz we are friends. Finally
A post shared by Sam Smith (@samsmith) on Apr 1, 2019 at 1:54pm PDT
The post Zac Efron, Martin Shkreli, Nancy Pelosi, the Sussex Royals, Kamala Harris, Michael Bloomberg, Adam Schiff's Nicknames, Sam Smith: HOT LINKS appeared first on Towleroad Gay News.


Disclosure: It is our company policy to abide by the Fair Credit Reporting Act, which means that we must verify all applicants' identities before proceeding to run a credit report. In addition, our policy is to submit all identification, banking statements and application fees in person prior to credit and background screening and to have all parties present for the execution of the lease agreement.
Background Authorization and Consent: I authorize JAMCO Properties, Inc. to obtain the information described in my residency application for the purpose of evaluating my application for residency. The information required in my residency application is for the sole purpose of conducting a background investigation which may include credit history, civil and criminal information, records of arrest, rental history, salary details, vehicle records, licensing records, and any other necessary information. Information regarding date of birth is requested for the sole purpose of gathering the above information accurately, as it is required by law enforcement agencies for positive identification purposes when checking public records, and it will not be used in violation of any law. I hereby release JAMCO Properties, Inc., and any other procurer or furnisher of the information, from liability whatsoever in the use, procurement, or furnishing of such information, and understanding that my application information may be provided to various local, state and/or federal government agencies, including without limitation, various law enforcement agencies. I hereby state the information given by me in my residency application is true. I agree that if any information is found to be false or incomplete in any respect, I will be subject to rejection of my application or termination of my residency benefits. I give permission for an investigation to be conducted now or at any time during my residency.
I agree to be screened after payment of application fees. If I cancel this application after 72 hours or refuse to occupy the premises on the agreed upon date, then I acknowledge, understand and agree that the Non-Refundable Pet Fee will be refunded, Non-Refundable Leasing Fee and Security Deposit will not be refunded. Application Fees are Non-Refundable regardless of approval status. THIS APPLICATION IS NOT A LEASE AGREEMENT.


Although cancer chemotherapy has historically been considered immune suppressive, we now understand that combining chemoimmunotherapy incites a mechanism called Immunogenic cell death. These mechanisms are now moving from concepts to the clinic. Recently dramatic advances in lung cancer treatment by combining chemotherapy with immunotherapy have led the way to this new frontier in cancer medicine. We will explain the mechanism behind ICD and how it will perhaps breathe a new life into chemotherapy use in cancer, not front and center but as a helpful hand to immunotherapy.
Galluzzi L, Buqué A, Kepp O, Zitvogel L, Kroemer G. Immunogenic cell death in cancer and infectious disease. Nature Reviews Immunology. 2016;17:97-111.
Okada H, Mak TW. Pathways of apoptotic and non-apoptotic death in tumour cells. Nat Rev Cancer. 2004;4(8):592-603.
Tesniere A, Schlemmer F, Boige V, et al. Immunogenic death of colon cancer cells treated with oxaliplatin. Oncogene. 2010;29(4):482-491.
Storkus WJ, Falo LD, Jr. A 'good death' for tumor immunology. Nat Med. 2007;13(1):28-30.
Emens LA, Middleton G. The Interplay of Immunotherapy and Chemotherapy: Harnessing Potential Synergies. Cancer Immunol Res. 2015;3(5):436-443.
van der Most RG, Robinson BW, Lake RA. Combining immunotherapy with chemotherapy to treat cancer. Discov Med. 2005;5(27):265-270.
Yatim N, Cullen S, Albert ML. Dying cells actively regulate adaptive immune responses. Nat Rev Immunol. 2017;17(4):262-275.
Kroemer G, Galluzzi L, Kepp O, Zitvogel L. Immunogenic cell death in cancer therapy. Annu Rev Immunol. 2013;31:51-72.
Zitvogel L, Galluzzi L, Smyth MJ, Kroemer G. Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. Immunity. 2013;39(1):74-88.
Kepp O, Senovilla L, Vitale I, et al. Consensus guidelines for the detection of immunogenic cell death. Oncoimmunology. 2014;3(9):e955691.
Sanchez-Perez L, Suryadevara CM, Choi BD, Reap EA, Sampson JH. Leveraging chemotherapy-induced lymphopenia to potentiate cancer immunotherapy. Oncoimmunology. 2014;3(7).
Yewdell JW. DRiPs Solidify: Progress in Understanding Endogenous MHC Class I Antigen Processing. Trends Immunol. 2011;32(11):548-558.
Zitvogel L, Tesniere A, Kroemer G. Cancer despite immunosurveillance: immunoselection and immunosubversion. Nat Rev Immunol. 2006;6(10):715-727.
Ma Y, Adjemian S, Mattarollo SR, et al. Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells. Immunity. 2013;38(4):729-741.
Bianchi ME. HMGB1 loves company. J Leukoc Biol. 2009;86(3):573-576.
Apetoh L, Ghiringhelli F, Tesniere A, et al. The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy. Immunol Rev. 2007;220:47-59.
Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G. Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol. 2010;11(10):700-714.
Hellwig CT, Rehm M. TRAIL signaling and synergy mechanisms used in TRAIL-based combination therapies. Mol Cancer Ther. 2012;11(1):3-13.
Panaretakis T, Kepp O, Brockmeier U, et al. Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. EMBO J. 2009;28(5):578-590.
Chan CJ, Andrews DM, McLaughlin NM, et al. DNAM-1/CD155 interactions promote cytokine and NK cell-mediated suppression of poorly immunogenic melanoma metastases. J Immunol. 2010;184(2):902-911.
Sukkurwala AQ, Martins I, Wang Y, et al. Immunogenic calreticulin exposure occurs through a phylogenetically conserved stress pathway involving the chemokine CXCL8. In: Cell Death Differ. Vol 21.2014:59-68.
Obeid M, Tesniere A, Ghiringhelli F, et al. Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med. 2007;13(1):54-61.
Klebanoff CA, Gattinoni L, Restifo NP. CD8+ T-cell memory in tumor immunology and immunotherapy. Immunol Rev. 2006;211:214-224.
Finn OJ. Immuno-oncology: understanding the function and dysfunction of the immune system in cancer. Ann Oncol. 2012;23 Suppl 8:viii6-9.
Lynch TJ, Bondarenko I, Luft A, et al. Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study. J Clin Oncol. 2012;30(17):2046-2054.
Maio M, Di Giacomo AM, Robert C, Eggermont AM. Update on the role of ipilimumab in melanoma and first data on new combination therapies. Curr Opin Oncol. 2013;25(2):166-172.
Buchbinder E, Hodi FS. Cytotoxic T lymphocyte antigen-4 and immune checkpoint blockade. J Clin Invest. 2015;125(9):3377-3383.
Gadgeel SM, Stevenson J, Langer CJ, et al. Pembrolizumab (pembro) plus chemotherapy as front-line therapy for advanced NSCLC: KEYNOTE-021 cohorts A-C. http://dxdoiorg/101200/JCO20163415_suppl9016. 2017.
Langer CJ, Gadgeel SM, Borghaei H, et al. Carboplatin and pemetrexed with or without pembrolizumab for advanced, non-squamous non-small-cell lung cancer: a randomised, phase 2 cohort of the open-label KEYNOTE-021 study. Lancet Oncol. 2016;17(11):1497-1508.
Gandhi L, Rodriguez-Abreu D, Gadgeel S, et al. Pembrolizumab plus Chemotherapy in Metastatic Non-Small-Cell Lung Cancer. N Engl J Med. 2018;378(22):2078-2092.
Socinski MA, Jotte RM, Cappuzzo F, et al. Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC. N Engl J Med. 2018;378(24):2288-2301.
Jotte RM, Cappuzzo F, Vynnychenko I, et al. IMpower131: Primary PFS and safety analysis of a randomized phase III study of atezolizumab + carboplatin + paclitaxel or nab-paclitaxel vs carboplatin + nab-paclitaxel as 1L therapy in advanced squamous NSCLC. Journal of Clinical Oncology. 2018;36(18_suppl):LBA9000-LBA9000.
Hellmann MD, Ciuleanu TE, Pluzanski A, et al. Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden. N Engl J Med. 2018;378(22):2093-2104.


Chopard Amber Malaki, is the latest addition to the Malaki Collection. With its sensuous, powerful and captivating accords, it represents a truly magical sensory experience. Like a precious stone, amber has captivated humans for centuries with its mesmerizing beauty. Golden amber is the seductive heart of this latest fragrance.


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Must-See TV? Twitter's Livestreaming Play Has Me Excited
By Ernie Smith / Jul 12, 2016 (Twitter screenshot)
Twitter and livestreaming go together like peanut butter and chocolate, and Twitter may have found the perfect formula. It's one that any organization with a large-scale event should keep an eye on, because they might want to try it someday.
The livestreaming of events has clearly held quite a bit of value for attendees who found themselves stuck at home. Heck, the Racehorse Owners Association just re-angled its whole event around livestreams.
Last week, however, the idea of streaming content online may have hit critical mass—for a variety of wildly different reasons.
The most obvious (and troubling) example of this was at the top of the news cycle, where the death of Philando Castile after being shot by a police officer—a tragedy recorded by his girlfriend and published via Facebook Live—showed that live video is about more than manufactured moments. It can be used to tell stories of vital importance in a way you can't with any other medium. That's even if you'd like to look away, as a lot of people did when they heard about the video of Castile.
As sad and deeper-question-creating as that all is, such notice is likely to give livestreams cultural acceptance in many walks of life, not just as a news or advocacy tool, but as a basic communication tool. We're past the days of ChatRoulette's shock factor for the sake of shock, as well as the janky solutions that kept online livestreaming a niche option.
My focus today, however, is further down the news cycle, where one social network's livestream offering has me thinking very big picture.
Last week, Twitter started streaming live from Wimbledon, combining live video from the Grand Slam tennis tournament with a sidebar of related tweets in a dead-simple but genius combination of television and technology. It's something of a dress rehearsal for Twitter, which won a streaming partnership with the National Football League. Thursday Night Football is about to make Twitter into more than just a second screen for sports fans: It may, in fact, be the first screen for a whole lot of people.
Twitter is also said to be eyeing a number of other streaming opportunities, and on Monday, it announced a deal with CBS News to livestream the two major political conventions this month.
That's an awesome place for Twitter to be as a company. Facing headache after headache from Wall Street, CEO Jack Dorsey may have found a way to turn Twitter into a more mainstream tool without scaring off the power users that give it cultural relevance.
Twitter just created a way to marry prowess as a conversation-owner with many of the ideas that have made companies like Twitch into major niche offerings.
And I wonder if this livestreaming approach will eventually fall into the hands of people with smaller events.
big Potential
As a lot of folks know, Twitter is the place to be during a big event. It's perfectly suited for real-time conversations. It allows in-person attendees to get their own voices out there, to network, to launch their own deeper conversations about the things they're learning.
Twitter just created a way to marry that prowess as a conversation-owner with many of the ideas that have made companies like Twitch into major niche offerings.
Twitch, owned by Amazon, already plays a big role in the Games Done Quick series of charity events, as I explained last year. But its focus on the gaming community limited its reach. (Not that Twitch probably minds, considering that it has such a tight hold on that audience.)
But Twitter already owns a good chunk of the conversation. There's nothing stopping it from expanding beyond sporting events and putting the technology to good use at super-events like SalesForce's annual DreamForce conference, the Consumer Electronics Show, or South by Southwest.
(It even has a good excuse to do it for SXSW. The event next March will be the 10-year anniversary of Twitter's coming-out party at the Austin, Texas, festival.)
And if Twitter and Dorsey were really smart, they would sell livestreaming even further down the food chain.
A Revenue Model?
Twitter has always been dogged to a degree by the reputation that it's an open-ended network that speaks to specific groups with specific interests. It does well with relatively narrow audiences and with people who have large tribes of their own (see Bieber, Justin), but it has trouble winning over the broader public because of its slightly esoteric nature and the fact that it's less focused on friends than Facebook and Instagram are.
This issue has people who care more about their stock portfolios than their audiences frequently discussing how disappointing Twitter is as a company, and why the company should sell to the highest bidder.
On the other hand, it's pretty much a perfect communication vessel for associations, which are nothing if not niche and designed to enable people to speak to one another. Twitter can help broaden an organization's reach, as well: Not everyone can make it to every event, and if members or other potential attendees are stuck at home or the office, they can still get a little bit of the hashtag magic.
It's tough to make money from people simply tweeting out your content and never making it to your events, but livestreaming is a different beast: It could create some new revenue streams if executed properly.
It's not too much of a reach to see associations livestreaming events of their own using Twitter, sponsored by advertisers and with potential premium offerings for some users, like daily content breakdowns via email. And, hey, if Twitter actually allowed associations to charge for the video stream, that would be even better—but even if it didn't, the potential to draw in new members with this technology could make the investment worthwhile.
During the past five years or so, we've seen an impressive improvement in the recording capabilities and production values of livestreaming, but two-way communication via the technology has taken a backseat. Before this year, the execution was off, to put it mildly.
For tennis and football, at least, Twitter may have figured out a way to make livestreaming work as both a broadcast and a communication medium. I'm keeping my fingers crossed that they make it work for you and your members—because it could be a game changer.
Should You Crowdsource Your Event's Note-Taking?Ernie Smith
A New Strategy for Event Social MediaErnie Smith
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