The United States Government is within 5 days of being shutdown by the extremist, Tea Party faction of the Republican controlled House of Representatives. Please visit my politics blog if you are interested in following this story. You will find a link to my countdown timer itself so you can watch it countdown in realtime.
If you want to understand more about one of the key figures behind the Tea Party efforts to shutdown the government take a look at the following great article from The Guardian.
Look George, you gonna be whupped all through the courts. And when you're whupped in the courts, the Klan's gonna come out on the streets and the killing's gonna start. You know what's gonna happen.
Wallace knew Flowers was right. He just didn't care.
His currency with his constituency did not come from winning, or even fighting, per se. His aim was to perform resistance in such a manner that nobody could say he hadn't tried – even if he had no chance of winning.
Damnit, send the Justice Department word, I ain't compromising with anybody. I'm gonna make 'em bring troops to this state.
It had been little more than a ceremony of futility. And, as a historical moment, a rather pedestrian production. But no other southern governor had managed to strike even that dramatic a pose of defiance and it has never been required of southern popular heroes that they be successful. Indeed, southerners tend to love their heroes more for their losses.
Ted Cruz's filibuster to prevent the implementation of Obamacare with the threat of shutting down the government has all the hallmarks of the "noble defeat" of southern Democrats from the mid-sixties onward. He is not so much opposing healthcare reform as protesting its inevitability.
Lest there be any confusion, I am not arguing Cruz is in any way a supporter of segregation or admirer of the late Wallace in his darker days. The comparison relates to his strategy, not his specific intent. It is in Cruz's buffoonery, showmanship and tactical disingenuousness that he poses now as Wallace in drag.
It is telling that the record for the longest filibuster in US history up this point goes to the late Senator Strom Thurmond from South Carolina, who was opposing civil rights legislation. As Cruz took to the Senate floor Tuesday, vowing to speak "until I am no longer able to stand", it was clear that efforts to block the healthcare reform were fruitless. The Democrats are the majority in the Senate. Even the filibuster is pointless because procedures exist that were bound to force Cruz to yield the floor by Wednesday afternoon.
We're in the minority [in the Senate]. We have to find a way of standing up for our principles without immolating ourselves in front of everybody, in a way, when we don't have the votes to do it.
But there stood Cruz, backed by his hardline tea party colleagues, going down in flames and lighting the path towards legislative irrelevancy, while reading Green Eggs and Ham and talking about Ashton Kutcher for as long as his voice and legs would hold.
A great many Texans, a great many Americans feel they do not have a voice, and so I hope to play some very small role in providing the voice.
With victory would come responsibility. He would actually need a plan for what to do about healthcare – as the senator for a state where 33% of adults and 17% of children have no health insurance. Not for the first time with the Tea Party, there is no plan B. Oppositionist by instinct and obstructionist by intent, their aim, from the debt ceiling to the budget, has always been to block and bluster.
As such, Cruz comes by his intransigence honestly. As with Wallace, one might even argue that even if it makes no sense legislatively, it does makes sense for him politically. Cruz has eyes on the 2016 presidential race when he will be standing in a party in which, according to a recent Gallup poll, people are evenly split on whether compromise is a good thing. Cruz will be seeking support from the wing of his party (the Tea Party) that is far more likely to champion the notion that a politician should "stick to his beliefs", than average Republicans are.
Cruz didn't come to the Senate to legislate – which demands compromise – but to perform. Now, he's turning Congress into his circus.


Trainer Anthony Freedman's son Sam is overlooking the Brisbane Winter Racing campaign of the stable's gun Japanese import Ambitious and is tipping the galloper to return to "world class" form in Saturday's 2018 Doomben Cup.
Jockey Craig Williams has the mount on Ambitious in Saturday's Doomben Cup 2018 field. Photo: Ultimate Racing Photos.
The Group 1 $650,000 Hardy Brothers Doomben Cup (2000m) steals the show on Saturday and the field is down to a dozen after the scratching of the Godolphin-raced It's Somewhat (8) due to a virus.
It is a wide open affair in the latest Doomben Cup odds at Ladbrokes.com.au with three single figure hopefuls including Deep Impact six-year-old Ambitious at $4.50.
He trails on Mick Price's last start A.D. Hollindale Stakes winning mare Oregon's Day ($4) and has ace hoop Craig Williams aboard for his fourth Group 1 bid down under.
The entire debuted down under at Flemington on March 10 at 'Super Saturday' when ninth, only four lengths off the winner Harlem in the Group 1 Australian Cup (2000m).
He improved heading to Sydney next-up later in the month when second as a $21 chance behind Almandin in Rosehill's Group 1 Tancred Stakes (2400m) over the mile and a half.
Last time out Ambitious took on the world's best mare Winx in Randwick's Group 1 Queen Elizabeth Stakes (2000m) where ran a disappointing but forgivable eighth.
Freedman has warned punters not to write the horse off based on the Queen Elizabeth Stakes run and that the galloper, a winner of over $3.3 million in career prize money, was set for better things in Brisbane.
"He'd done everything right since he's been in Queensland and I couldn't be happier," he told Racing Queensland.
"He's got no vices, and intellectually, he's a great horse to deal with.
"You have to forget his run in the Queen Elizabeth as he pulled three shoes.
The feet issues that have so far seen Ambitious end up winless in Australia are now behind him according to Freedman who is full of pre-race confidence going into the Doomben Cup.
"He's had a long preparation but he's freshened up nicely for tomorrow," he said.
Ambitious has won five of his 19 career starts to date but hasn't been first past the post since defeating subsequent Japan Cup champion and multiple Group 1 Japanese star Kitasan Black in a Group 2 over 2000m in April of 2016.
Freedman's father Anthony is after a third Doomben Cup success.
He prepared Mawingo for a win in the wet back in 2012, his first success as a solo trainer, before success again in 2016 preparing Our Ivanhowe for an upset win at 15/1 in partnership with his brother Lee two years back.


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redpajama_set_name: RedPajamaGithub


text:
Here's where most Americans are really getting their retirement income
Rare coin featuring King Edward VIII sells for $1.3 million
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Business News Plus
Latest Business News In One Place
Here's what top advisors see on the horizon for markets in 2020
December 11, 2019 ayman022 0 Comments
PeskyMonkey | iStock | Getty Images
The bull market in U.S. stocks rolls on.
From the trade war between the U.S. and China and the slowdown in global economic growth, to Britain's messy exit from the European Union and the potential impeachment of President Trump, nothing has dampened the enthusiasm for stocks.
The American economy remains in the midst of the longest economic expansion on record and the longest — if not strongest — bull market in stocks. Despite some concerns about higher volatility from a range of potential factors, registered investment advisors expect 2020 could be another good year for both the economy and the stock market.
"The cycle has been long but the economy has also been slower than in past cycles and without the big imbalances we've seen previously," said Alan Cohn, president of Sage Financial, ranked No. 50 on the CNBC FA 100 list of top investment advisors for 2019. "With interest rates low and the U.S. economy good, we think there's still room to run."
More from FA 100:
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"We're clearly extended in the cycle but that doesn't mean that it can't continue," added Jason Graybill, co-director of fixed income at Carret Asset Management and a member of the firm's investment committee. Carret is ranked No. 14 on the FA 100 list. "There are global risks out there but we think there's a high probability that 2020 could be another good year."
Topping most advisors' list of risks is the trade war between the U.S. and China — the world's two biggest economies. Since the battle erupted last year, when President Trump began levying tariffs on Chinese-made products, business confidence and capital expenditures have slipped, contributing to the recent tapering of global economic growth.
Graybill thinks the slowdown now presents an opportunity for at least partial resolution of the dispute.
"All eyes are fixated on trade," he said. "We've seen slower growth in the last two or three quarters due to the uncertainty and that creates the opportunity to resolve some of the tariff issues."
A so-called Phase 1 trade deal would see the U.S. postpone new tariffs set to take effect this month and begin rolling back previously levied tariffs as China agrees to resume more purchases of U.S. agricultural products. "It's our view that President Trump and the administration don't want to have tariffs in the election headlines next year," said Graybill. With growth also slowing significantly in China, it, too, has a strong incentive to strike a deal.
While the U.S.-China dispute still has business leaders nervous about investing new capital, trade is not the only factor affecting the economic outlook. With the U.S. currently at record low unemployment and consumer spending still solid, the economy continues to grow, albeit at a slower pace.
"It's important not to focus solely on one issue like trade," Cohn said. "We're seeing better corporate earnings than expected and lower interest rates are driving the [stock] market higher."
Federal Reserve Chairman Jay Powell and, as President Trump has called them, the "boneheads" at the Fed deserve a good deal of the credit, despite frequent withering criticism from the commander in chief. Earlier interest rate hikes followed by a "mid-cycle adjustment" of three rate cuts has restored market confidence that the Fed will respond to signs of further economic weakness.
"If the economy softens and people have less ability to service debt, the Fed will lower rates further," said Graybill, whose firm invests three quarters of its $2.9 billion in assets under management in fixed income. The current Fed Funds rate is 1.5% to 1.75%.
We expect more volatility in the stock market if companies miss expectations, but that will give us opportunities to add names to our portfolio.
Michael Morrill
chief operating officer at D.F. Dent and Company
Graybill focuses solely on the U.S. fixed income market.
"we stick to what we're good at," he said.
However, he believes the flexibility that the Fed still has relative to other developed markets in Europe and Japan that currently have negative interest rates provides more potential support for domestic bond prices.
"There has been so much central bank intervention globally," he said. "If they back off now, interest rates could rise rapidly," he said.
Nevertheless, Graybill is underweight U.S. Treasury bonds.
"We think U.S. Treasurys are one of the more over-valued areas of the fixed income landscape," Graybill said.
After bottoming below 1.5% in early September, the yield on the 10-year Treasury bond has risen to 1.76%.
"It's not enough compensation for the duration risk," he said.
Instead he favors corporate credit risk on the short-end of the market again because of the duration risk of holdings bonds in such a low-rate environment.
Cohn's firm is also overweight U.S. bonds versus other developed markets, though it maintains an allocation to higher-yielding emerging market bonds. Sage brought down exposure to emerging market stocks and bonds in July when it became clear the U.S.-China trade war could be protracted but still believes in emerging markets "in a structured way."
"The economies are growing faster, the demographics are favorable and the valuations are good," Cohn said. "We expect to see stronger returns there."
He also favors so-called unconstrained bond funds that can invest anywhere and change strategies quickly based on changing circumstances. "We like them heading into an election year," said Cohn. "We think volatility could pick up with comments from a candidate like Elizabeth Warren or Bernie Sanders."
Sen. Elizabeth Warren (D-Mass.), former Vice President Joe Biden and Sen. Bernie Sanders (I-Vt.) at the Nov. 20 Democratic Presidential Debate in Atlanta.
Alex Wong | Getty Images News | Getty Images
Michael Morrill, a portfolio manager and chief operating officer at D.F. Dent and Company, No. 20 on the FA 100 list, doesn't spend much time thinking about the economic outlook. "We're bottom-up stock-pickers and less interested in the short-term outlook," he said. "We keep an eye on the macroeconomic picture but we don't obsess over it."
Morrill said his firm looks to own stocks of "good companies with great management teams" for a five- to seven-year period based on fundamentals and valuation. He sticks to U.S. stocks and, as a growth manager, his largest sector weightings are currently technology, business services and health care. He is avoiding utilities, consumer staples and energy companies.
Morrill does have some concerns about corporate earnings in the coming year, given the highly valued market. "It's tougher to find new ideas," he said. "We expect more volatility in the stock market if companies miss expectations, but that will give us opportunities to add names to our portfolio."
If enough of the smart money sees volatility as opportunity, the bull market could roll on in 2020.
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redpajama_set_name: RedPajamaCommonCrawl


text:
The 2010 BSWW Mundialito was a beach soccer tournament that took place at a temporary stadium at Praia da Rocha, Portimão, Portugal from August 6 to 8. This competition was played in a round-robin format.

Participating nations

Final standings

Schedule and results

See also
Beach soccer
BSWW Mundialito
Euro Beach Soccer League

References

External links
Beach Soccer Worldwide
Mundialito page at Portimão web site

BSWW Mundialito
2010–11 in Portuguese football
2010 in beach soccer

redpajama_set_name: RedPajamaWikipedia


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Blend Expands Digital Lending Platform with New Configuration Capabilities for Consumer Banking
Medical insurance premiums rising at an unsustainable rate, says LIAM
Twisted Tapas In Rogers Park Joins List Of Restaurants Going Out Of Business Due To COVID-19
Stocks Rise as Economic Recovery Still Looks Strong
This Aviation Entrepreneur Scaled Private Jet Charter Business to a Global Brand and Focuses on Providing a New Standard of Service to Their Clients
Signature Bank Announces Issuance of Subordinated Notes
Euromoney China's digital currency: A small leap forward
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Mike Pence attacks Joe Biden economic plan that would raise taxes
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Capital Group Boosts Stake in Deutsche Bank
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Uquid Launch the Defi Shopping Stake (DSS) and Defito Finance (DTO)
The trouble with many current DeFi projects is that while they eliminate traditional institutions from the mix, they instead transfer ultimate control over to a select group of insiders who have their financial motives and agendas. It's an arrangement that's ripe for abuse, and something that should be anathema to […]
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BUSINESS FINANCE The United Kingdom based TLG Capital (TLG) has purchased 49% of Opportunity Bank Uganda Ltd (OBUL) from MyBucks SA – according to a statement by the London based firm. The transaction makes TLG the largest shareholder of OBUL. Remaining shareholders (all NGOs) include Opportunity International Group (43%), Faulu […]
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Black Dog Venture Partners Acquires a 50% stake in Restaurant Ordering Application, OnPlate Technologies
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HSBC shares enjoy their best daily surge for more than a decade after Chinese investor ramps up stake in embattled bank
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Ping An buys HSBC stake, stocks rally on China data
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Specialities: Behavioral Weight Management, Weight Loss Surgery Evaluations Binge Eating Disorder, Insomnia, Depression, Stress Management, Anxiety Disorders, Coping with Chronic Health Conditions (i.e. Chronic Pain, Diabetes).
Dr. Lindsey Berisha is a licensed clinical psychologist with advanced training and expertise in clinical health psychology. She provides evidence-based interventions for behavioral weight management, binge eating disorder, insomnia, depression, stress, and anxiety. She also works with individuals managing and coping with chronic health concerns such as chronic pain and diabetes. Additionally, she works with individuals both before and after weight loss surgery, and has expertise in conducting psychological evaluations for individuals considering surgery. Dr Berisha has been conducting psychological evaluations for bariatric surgery for the past 10 years, and was the lead psychologist in the weight loss surgery program at Walter Reed National Military Medical Center.
Dr. Berisha primarily uses Cognitive Behavioral Therapy (CBT) and Acceptance and Commitment Therapy (ACT) in her work with clients. Both approaches help individuals gain insight into the relationships among their thoughts, feelings, and behaviors, and develop alternative strategies to help improve distress and break unhelpful patterns. She helps clients to examine and resolve ambivalence, and to enhance and maintain motivation for long-term change.
Dr. Berisha also has experience working with military service members, veterans, and their family members, having previously worked at Walter Reed National Military Medical Center and VA Connecticut Healthcare System. Additionally, she has led trainings across the country to educate physicians and other medical providers about the psychological aspects of behavior change and to equip providers with skills to assist their patients in making lasting changes to manage their health.
Dr. Berisha received her Ph.D from Virginia Commonwealth University in Richmond, and completed her internship and postdoctoral residency at VA Connecticut Healthcare System before being hired on as a staff psychologist. She also served as an Assistant Professor at Yale School of Medicine, Department of Psychiatry. She continues to collaborate with colleagues on research studies, primarily focused on eating behaviors and weight.


The documentation of "System.Environment.getProgName" says that "However, this is hard-to-impossible to implement on some non-Unix OSes, so instead, for maximum portability, we just return the leafname of the program as invoked." This library tries to provide the missing path. Note: Since base 4.6.0.0, there is also a function "System.Environment.getExecutablePath".


text:
Albert Hoffa (* 31. März 1859 in Richmond, Kapkolonie (Namakwa/Südafrika); † 31. Dezember 1907 in Köln) war ein deutscher Chirurg und Orthopäde.

Leben
Hoffas Vater war Moritz Hoffa, der aus Kassel stammende erste deutsche Arzt in Pretoria. Die Mutter war Mathilde Hoffa geb. Lelienfeld.

Albert Hoffa kam als Kind nach Deutschland. Nach dem Abitur in Kassel studierte Hoffa Medizin an der Philipps-Universität Marburg. 1879 wurde er im Corps Hasso-Nassovia aktiv. Als Inaktiver wechselte er an die Albert-Ludwigs-Universität Freiburg, die ihn 1883 zum Dr. med. promovierte.

Würzburg
Mit Hermann Maas ging er an die Julius-Maximilians-Universität Würzburg. Am Juliusspital, wo er chirurgisch arbeitete, habilitierte er sich 1886 für Chirurgie. 1893 heiratete er Sophie Günther (1867–1938). 1892 gründete er die Zeitschrift für orthopädische Chirurgie, deren Herausgeber er bis zu seinem Tod war. Seit 1895 apl. Professor, lehrte er Orthopädie und gründete 1887 mit Ernst Bumm in Würzburg eine Privatklinik für Orthopädie, Heilgymnastik und Massage. Er betrieb die Eigenständigkeit der Orthopädie und gehörte 1901 zu den Gründern der Deutschen Gesellschaft für Orthopädische Chirurgie.
Sein 1891 erstmals erschienenes Lehrbuch der orthopädischen Chirurgie ist eine Zusammenfassung der damaligen Möglichkeiten konservativer und operativer Behandlungsverfahren der Orthopädie.
Zu seinen Schülern gehörten unter anderem Hermann Gocht, August Blencke, Hans Spitzy, Alfred Schanz, Gustav Drehmann und Gustav Albert Wollenberg.

Berlin
Die Friedrich-Wilhelms-Universität zu Berlin berief ihn 1902 als außerordentlichen Professor und Direktor der Universitätspoliklinik für Orthopädische Chirurgie. Hoffa forcierte die operative Akzentuierung der Orthopädie, nahm aber zugleich die Technische Orthopädie und die Physiotherapie in ärztliche Verantwortung. Ihm gelang die erste offene Reposition einer angeborenen Hüftluxation. Er erweiterte die orthopädische Ausbildung um neurologische, radiologische und internistische Inhalte. Im Anhang seines weltberühmten Lehrbuchs der orthopädischen Chirurgie (1905) erschien die erste orthopädische Bibliographie, die er mit August Blencke erstellt hatte.

Tod
Albert Hoffa laborierte bereits seit etwa zehn Jahren an Diabetes und einem Herzleiden, als sich während einer an Weihnachten 1907 aus beruflichen Gründen nach Antwerpen unternommenen Reise schwere Herzbeschwerden einstellten, die ihn zur Bettruhe zwangen. Die dennoch angetretene Rückreise musste er in Köln unterbrechen und sich schließlich ins dortige Augusta-Hospital einweisen lassen, wo er am Silvesterabend im Alter von 48 Jahren verstarb. Bei der Obduktion wurde Atherosklerose der Herzkranzgefäße festgestellt. Beigesetzt wurde Albert Hoffa am 4. Januar 1908 auf dem Kaiser-Wilhelm-Gedächtnis-Friedhof in Charlottenburg (heutiger Ortsteil Berlin-Westend). Das Grab ist erhalten.

Seine Ehefrau überlebte ihn um mehr als 30 Jahre. Von seinen fünf Töchtern wurde Elisabeth Hoffa ebenfalls Ärztin.

Soziale Medizin
Hoffa erkannte die sozialmedizinischen Probleme bei Behinderungen. Er initiierte die erste umfassende Statistik aller krüppelhaften Kinder (1906) und warb für die fachärztliche Überwachung von Schul- und Berufsausbildung. Zum Zweck der Fürsorge setzte er die Gründung entsprechender Spezialanstalten durch. Die Kinderheime in Bad Sodenthal und Groß-Lichterfelde, das Cäcilienheim für Knochen- und Gelenktuberkulose in Hohenlychen, die Berlin-Brandenburgische Krüppelerziehungsanstalt als Vorgängerin des Oskar-Helene-Heims und das Humboldt-Sanatorium auf Teneriffa verdankten ihm die Errichtung.

Werke
 Lehrbuch der orthopädischen Chirurgie (Stuttgart 1891 u. ö.), übersetzt in viele Sprachen.
 Die ambulante Behandlung der tuberkulösen Hüftgelenkentzündung mittels portativer Apparate. Lipsius & Fischer 1893.
 Über Krüppelelend und Krüppelfürsorge, 1906.
 Technik der Massage (1893); 9. Auflage mit Hermann Gocht und Hans Storck (1937)
 Atlas und Grundriss der Verbandlehre (1900)
 Lehrbuch der Fracturen und Luxationen für Ärzte und Studierende, 1887/88.
 Die Nachbehandlung der nach abgelaufener Coxitis zurückgebliebenen Deformitäten. Breitkopf & Härtel, Leipzig 1896.
 Die moderne Behandlung der angeborenen Hüftgelenksverrenkung. Seitz & Schauer, München 1898.
 Die neueren Forschungen über Pathologie und Therapie der Silikose, 1898.
 Die chronisch ankylosirende Entzündung der Wirbelsäule (Strümpell). Breitkopf & Härtel, Leipzig 1899.
 Die Osteotomie bei der Behandlung der Hüftgelenksdeformitäten. A. Stuber's Verlag (C. Kabitzsch), Würzburg 1899.
 Die moderne Behandlung des Klumpfusses. Seitz & Schauer, München 1899.
 Die moderne Behandlung der Spondylitis. Seitz & Schauer, München 1900.
 Die Orthopädie im Dienste der Nervenheilkunde, 1900.
 Die Prophylaxe in der Chirurgie. Seitz & Schauer, München 1900.
 mit Ludwig Rauenbusch: Atlas der orthopädischen Chirurgie in Röntgenbildern. Enke, Stuttgart 1906.
 Operationen am Skelettsystem. In: Georg Joachimsthal: Handbuch der orthopädischen Chirurgie I, 1905/07.
 mit Gustav Albert Wollenberg: Arthritis deformans und sogenannter chronischer Gelenkrheumatismus; eine röntgologische und anatomische Studie. Enke, Stuttgart 1908.

Ehrungen
 Geheimer Medizinalrat
 Büste im Kurpark von Soden
 Albert Hoffa-Preis der Norddeutschen Orthopädenvereinigung
 Albert Hoffa-Straße in Frauenland

Literatur

 Uwehorst Paul: 150 Jahre Berliner Orthopädie. Der Weg der Berliner Orthopädie und die gesellschaftliche Bedingtheit ihres Wandels. In: Uwehorst Paul: 150 Jahre Berliner Orthopädie (= Wissenschaftliche Schriftenreihe der Humboldt-Universität). Humboldt-Universität, Berlin 1985, S. 9–97.
 Erdmute Baudach: Eine Studie über Albert Hoffa und seine Resonanz in Amerika unter Berücksichtigung der Zeitumstände. Würzburg 1977 (Dissertation, Universität Würzburg, 1978).
 Barbara I. Tshisuaka: Hoffa, Albert. In: Werner E. Gerabek, Bernhard D. Haage, Gundolf Keil, Wolfgang Wegner (Hrsg.): Enzyklopädie Medizingeschichte. De Gruyter, Berlin/ New York 2005, ISBN 3-11-015714-4, S. 608.

Weblinks

 Enzyklopädie Medizingeschichte

Einzelnachweise

Orthopäde, Unfallchirurg
Sozialmediziner
Mediziner (19. Jahrhundert)
Mediziner (20. Jahrhundert)
Hochschullehrer (Humboldt-Universität zu Berlin)
Hochschullehrer (Julius-Maximilians-Universität Würzburg)
Herausgeber
Corpsstudent (19. Jahrhundert)
Geheimer Medizinalrat
Deutscher
Geboren 1859
Gestorben 1907
Mann
Absolvent der Albert-Ludwigs-Universität Freiburg


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The Period Products (Free Provision) (Scotland) Act 2021 was enacted in November 2020 by the Scottish Government, and received Royal assent on 12 January 2021. It is the world's first legislation to make it mandatory for all public institutions to provide free sanitary products for menstruation including tampons and pads. The act followed a campaign coordinated by Monica Lennon, MSP, the spokesperson on health for the Scottish Labour party, and obtained all-party support in the Scottish Parliament. The provision will cost an estimated £8.7 million annually.

History
The campaign for free period products had been led by Scotland. In 2017 the country's first minister had announced that period products would be free in Scotland's schools. It has been noted that other public toilets have followed the lead offering free products or free with an "honesty box". Similar schemes for schools have been promised for Ireland in 2020. The Scottish government had originally proposed that free products should be available on a means tested basis but changed its proposals in February given the wide support in the Scottish parliament.

The legislation came into force on 15 August 2022, making Scotland the first country to make such a provision.

References

Menstrual cycle
Acts of the Scottish Parliament 2020


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Desjardins making a name for himself
by Samantha Wood || for NHL.com
Cedrick Desjardins.
"I think (some) people know who he is, but by the end of this year, I think everyone's going to know who he is," said Lake Erie Monsters head coach David Quinn.
"There's no one better in the American Hockey League right now."
The numbers agree: Desjardins, in his first year in the Colorado Avalanche organization, leads the AHL in both goals against average (1.49) and save percentage (.952).
Just don't tell him that.
"I don't really care about the stats. I'm just looking to win every game," Desjardins said. "My main goal on the ice every night is to just help my team, and my teammates are doing the same for me.
"The numbers come by themselves. I just try to not give up that goal that could give the other team a chance to win."
Desjardins joined the Cleveland-based Monsters club after battling injuries last year with the Norfolk Admirals, the top affiliate for the Tampa Bay Lightning. He was having another strong campaign – which included an impressive showing in his NHL debut – but played just four periods during the second half of the 2010-11 season.
"Coming to Colorado, it was the first time that a team said, 'We trust you, we like the way you play, we want you to get healthy as soon as you're ready,'" said Desjardins. "They showed me a lot of confidence."
The Edmundston, N.B., native needed all the confidence he could get this summer, as he was about to begin an arduous rehabilitation process following surgery on a pre-existing injury. All told it forced him to miss the start of the season.
"That confidence gave me the motivation to get through that six-month rehab," he said. "I missed the first month of the season, but sometimes you have to take a step back to move forward.
"That was the main goal of my rehab – to move on and try to get my play to as high a level as possible."
And move on he did, as he returned to his place between the pipes on Oct. 30 and debuted with a 29-save shutout in a 4-0 victory over the Toronto Marlies.
Along with the support of the Avalanche organization, Desjardins said his recovery was bolstered by the memory of his first NHL action with the Lightning last season.
Desjardins, who had a career year (29-9-4, 2.00, .919, Second Team AHL All-Star) in 2009-10 playing for new Lightning head coach Guy Boucher with the AHL's Hamilton Bulldogs, received the call to head to Tampa Bay on Dec. 20, 2010. He ended up playing in back-to-back games for the Bolts, notching wins against the Montreal Canadiens on Dec. 30 and the New York Rangers on Jan. 1.
"You work all your life to get a shot at it," said Desjardins, who stopped 61 of 63 shots in his two NHL games. "I couldn't ask for a better start in the NHL. It was two big wins, and it was good for my confidence.
"I got hurt right after, but those two games gave me that little spark of energy to keep moving, motivation to come back and try to go and have another shot at it."
Exactly one year after that call-up – and with Desjardins back to his winning ways – the Monsters are thrilled to have their former nemesis in their net.
"We saw him a few years ago when he played for Hamilton and we got a front-row seat of how dominant he could be," said Quinn. "He's been a winner everywhere he's been."
Lake Erie is no exception. With his 7-4-1 record (in Desjardins' four regulation losses, the Monsters' offense has scored a grand total of one goal) and his league-leading GAA and save percentage totals, Desjardins is doing his part to help his Monsters move up in the standings – one save at a time.
"I don't think I've ever been around a goalie that works harder than Cedrick does," Quinn said. "He's been an elite goalie in this league for a couple years now and right now I don't think anyone's playing better than he is in that position."
Desjardins insists that gratitude is mutual.
"I'll be ready if they need me [in Colorado] and I'm thankful that they gave me the chance to get back to the level of play that I was at," he said. "The guys have been playing pretty good defensively to help me keep my confidence, and the way we're playing helps me to get my game at the highest level as possible."
At 26, Desjardins is in his sixth year as professional athlete, his third as a number-one goalie in the AHL. And though his injury and lengthy rehab may have put a bump in the road to a full-time position in the NHL, goalies like Tim Thomas, Jimmy Howard and Al Montoya are proving the benefits of patience and perseverance, and Desjardins wouldn't have changed the experience.
"For my part, I took maybe a little longer road," he said. "But at the same time, I always move forward one step at a time and try to not waste any season. There's a lot of adversity sometimes, but when you get your shot at the NHL, you want to enjoy that as much as possible. That's the reason why we're playing hockey."
He was also quick to offer advice for less-traveled players.
"It goes fast," he said. "Every year could be your break-out year to go to the NHL, especially when you start in the AHL. Don't waste time."
As Desjardins and Quinn look into the second half the season, they agree that they have one goal in mind – winning.
"When your team has that type of success collectively, individuals certainly benefit from it in the long haul," Quinn said. "People want winners and we think Cedrick's in a position to get us where we all want to go.
"We're looking to not only win our division but win a Calder Cup."
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Thais Rocha da Silva (St Benet's) fighting Blues Tae Kwon Do vs Cambridge
At Benet's, we have at least one, often two, sometimes three, rowing eights and regularly enter pretty much all competitions going. St Benet's is currently Rugby 7s Cuppers (inter-college competition) winners. If you want to take your game to an even higher level, then many Benet's students play for other colleges and it's easy to sort out. Everyone is encouraged to try out for the Blues (the name for Oxford University sports teams). If you are keen to play any sport at any level, please contact a member of the committee.
Women's novice boat racing in Christ Church Regatta
St Benet's Mens Eight successfully bumping in Summer VIIIs and achieving 'blades'
St Benet's Hall is one of Oxford's more unique and smallest boat clubs, yet has the strongest community spirit. The club brings together people from a huge range of backgrounds and competes in all the major Oxford University competitions, fielding an eight in Nephthys and Christ Church Regatta, as well as Torpids and Summer VIIIs.
The Boat Club has its own website which you can find here: http://sbhbccommittee.wixsite.com/sbhbc
Charlie Pozniak (St Benet's) playing Blues rugby vs Canada


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Summaries of health policy coverage from major news organizations
Monday, Oct 24 2016
Administration's Tough Campaign Against Medicare Fraud Busts Some Major Scams
The Justice Department reports that since 2010 the administration's task force has arrested and prosecuted 1,200 people for defrauding Medicare and Medicaid.
The Fiscal Times: Crackdown On Medicare Fraud Is Producing Some Impressive Results
After years of losing tens of billions of dollars through Medicare fraud, Justice Department and Health and Human Services officials, the FBI, government agency inspectors general, auditors and others have made important headway in slamming the door on fraudulent activities by doctors, hospitals, nursing home facilities, recruiters and conspiring patients. At the beginning of his second term, President Obama made combatting Medicare and Medicaid fraud a top priority – a decision that has led to a series of high-profile arrests and prosecutions by federal and state law enforcement agencies. (Pianin, 10/23)
The Hill: Nursing Homes Challenge New Rule Giving Residents Right To Sue
The nursing home industry is fighting back against new rules from the Obama administration that would give patients at federally funded facilities the right to settle disputes in court. Starting Nov. 28, nursing homes that accept Medicare and/or Medicaid funds will be banned from using pre-dispute arbitration clauses in resident contracts. The policy is being enacted under new rules from the Centers for Medicaid and Medicare services (CMS). The arbitration language — often slipped into the fine print — forces residents to settle disputes privately with an arbitrator rather than through the courts. (Wheeler, 10/23)
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Joanna Gaines' French Toast Crunch With A Nutella Twist
Susan Olayinka/ Mashed
By Susan Olayinka/Updated: Aug. 12, 2021 11:35 am EST
Joanna Gaines started off on the home remodeling show "Fixer Upper," and the brand has quickly spiraled into several other departments, including cooking. Gaines is now also known for whipping up some of the tastiest dishes, proving that there is literally nothing that she cannot do. While Gaines' recipe for French toast is incredible by itself, it's even better with a twist. Recipe developer Susan Olayinka of The Flexible Fridge is the mastermind behind this creation. The recipe has quite a few steps, but trust us when we tell you that the end result will be totally worth it.
Olayinka added Nutella to the French toast for her twist because let's be honest: Who doesn't love French toast and who doesn't love Nutella? The two together are a match made in heaven! The creator also opted to roll the toast to serve, making a delicious and fun breakfast treat that will knock your socks off. Keep scrolling to find out how to make this delightful dish that will please you and your guests while making it seem like you're a veteran chef!
Gather the ingredients
First, you will want to gather everything that you need to throw this breakfast dish together. It calls for 16 ingredients, and hopefully, you will have a lot of them on hand already. You'll want to get brioche bread, cornflakes, butter, and sugar. The recipe also calls for some cream of tartar, water, heavy cream, and salt. In addition, you will need a few eggs, vanilla extract, Nutella, and chopped hazelnuts. To round out the list, get some maple syrup, strawberries, whipped cream, and finally, powdered sugar.
Preheat and Prep
To start the recipe, preheat your oven to 375 degrees Fahrenheit. Once that's done, get out a baking tray and spread the cornflakes onto it. Set your timer for eight minutes, and then take out the cornflakes — the edges of the cereal will turn brown when they're done. Now, set the cornflakes aside to cool and move onto the next step. If you must, feel free to sample a few bites — it's very tempting. Who knew oven-baked cereal was so good?
Make the caramel
If you've never made your own caramel, it's surprisingly simple. Recipe creator Susan Olayinka says that homemade is a better option than store-bought. "The homemade caramel hardens sticking the cornflakes," Olayinka dishes. "I feel that store-bought caramel would harden but would just remain sticky which wouldn't work unfortunately." So, homemade is the way to go.
Get out a medium pan, sugar, and water. Turn on the stove and combine your ingredients in the pan and stir until it's all incorporated. Once everything is mixed together, turn the heat to low and watch it for four to five minutes. Do not stir at this time. When the mixture is done, it should be a translucent brown color.
Continue the caramel
Now that the mixture is a beautiful light brown color, take it off of the heat. Stir in two tablespoons of butter and mix it for 30 seconds. When the 30 seconds is up, add an eighth-cup of heavy cream, the cream of tartar, and the salt. Stir for another 60 seconds on medium heat. Now, the mix should have a thicker texture and look even more like caramel. If it's helpful, you can use the photo above as a guide
Cornflakes and carmel
Grab your toasted cornflakes and a big mixing bowl. Gently pour the caramel sauce into the bowl and on top of your cornflakes. It will be easier to stir if you evenly distribute it as best as you can. Now stir gently, trying not to break apart the cereal. Continue stirring until all of the cornflakes are coated with caramel. Set it aside and let it cool for about 30 minutes, until the caramel starts to harden a bit.
Continue the prep
When the 30 minutes are up, and the caramel and cornflakes are cooled, you're ready for the next step. Add the hazelnuts to the bowl. Then, get a rolling pin or a pestle and gently crush the mixture into smaller cornflakes. You don't want these as small as a fine powder, but you do want the pieces a little smaller than whole Cornflakes. This is the fun part where you can sneak in another bite as a taste-test.
Get another mixing bowl
Get out another mixing bowl for this step. Place the eggs, half a cup of heavy cream, and the vanilla extract in it. Now, give it a few good whisks until everything is well incorporated. The mix should be similar to what the photo looks like. A whisk is the best tool to use because it really helps get the egg mixture even. Set it aside and get out a chopping board because you will need this for the next step.
Prep the bread
Get out your loaf of brioche bread and trim off the crust. Flatten it carefully with a rolling pin and then spread the Nutella in an even layer on each slice. You will want to do this for all of the remaining slices of bread and roll them. Now, dip each piece of bread into the egg mixture and then allow the excess to drain off. Next, dip it into the caramel hazelnut crunch, making sure to coat every part. Do this for all the remaining bread.
Cook the bread
Once every piece of bread is dipped and ready to go, put on a cast-iron skillet over medium-high heat. Place two tablespoons of butter in the skillet, and when it's melted, the bread is ready to go in. Try and fit as many pieces as you can in the skillet without overcrowding. Leave it on for about two to three minutes per side and repeat for all the remaining pieces. The aroma should be filling your home and making your mouth water.
Now, it's time to dig in! Place the toast on a serving dish for you and any lucky guests who you have over. You can add powdered sugar, maple syrup, sliced strawberries, and whipped cream if you're big into toppings. The French toast won't keep well as leftovers so be sure to eat as much as you can so nothing goes to waste (though we hardly doubt it would). This dish is best if eaten immediately, so dig in!
Joanna Gaines' French toast crunch and Nutella are a match made in breakfast heaven. This hearty and delicious treat will be your new brunch or dessert go-to.
15 brioche bread slices
2½ cups cornflakes
⅛ teaspoon cream of tartar
0.625 cups heavy cream
⅛ teaspoon of salt
¼ cup Nutella
2 tablespoons hazelnuts
½ cup sliced strawberries
Optional Ingredients
1 squirt of spray whipped cream
1 tablespoons of powered sugar
Preheat oven to 375 degrees Fahrenheit.
Spread the cornflakes onto a baking tray and bake for 8 minutes, or until the edges have lightly browned.
After 8 minutes, set aside to cool.
To make the caramel, pour sugar and water in a medium pan. Gently stir the sugar mixture until incorporated.
Put the pan on low heat and do not stir the caramel for 4-5 minutes. The mixture should become a translucent light brown color.
Take the mixture off the heat when it turns light brown.
Stir in 2 tablespoons butter and gently mix for 30 seconds.
After 30 seconds, add ⅛ cup of heavy cream and salt. Stir for a further 60 seconds on medium heat. The caramel should have formed, changing to a thicker texture.
Put the toasted cornflakes into a mixing bowl then gently pour the caramel sauce into the bowl.
Gently stir until cornflakes are coated. Allow this to cool for about 30 minutes.
After 30 minutes, add the hazelnuts and get the end of a rolling pin or a pestle and gently crush the mixture into smaller cornflakes (you don't want a fine powder).
Get another mixing bowl and drop in eggs, 0.5 cup heavy cream, and vanilla extract. Whisk until well incorporated.
Get a chopping board. Place the brioche slices on it, trim off the crusts.
Roll each bread slice out carefully with a rolling pin and spread on an evenly thin layer of Nutella. Do this for the remaining brioche slices.
Roll bread slices.
Dip each brioche roll into the egg mixture, allowing it to drain, then dip it into the caramel-hazelnut crunch, making sure to coat every part.
Put a cast iron skillet on medium heat and melt 2 tablespoons of butter.
Once the butter is melted, place brioche rolls in the skillet (avoid overcrowding).
Cook for 2 to 3 minutes on each side.
Repeat until all the brioche rolls are cooked.
Place on a serving dish and top with optional powdered sugar, maple syrup, sliced strawberries, and spray whipped cream. Serve immediately.
Calories per Serving 1,434
Total Carbohydrates 186.8 g


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DISCONNECTED Release Official Music Video for "Life Will Always Find Its Way"
November 23, 2021 ColetteJosef Leave a comment
French Modern Metal band DISCONNECTED has released the official music video for "Life Will Always Find Its Way." Directed by Laurent Hart, "Life Will Always Find Its Way" is the second single off of their upcoming, sophomore album, We Are Disconnected, following the 2020 release of "Unstoppable," which garnered over 1.5 million streams across platforms. DISCONNECTED will also be joining such rock and metal legends as GUNS'N'ROSES, METALLICA, MEGADETH, ALICE COOPER, and NINE INCH NAILS at the upcoming HELLFEST Open Air Festival in Clisson, France June 15-26, 2022.
"Life will always find its way" is a statement to raise ecological awareness, and the urgency to act. It is a clear shout out for ecology!" – DISCONNECTED
Click HERE to Download / Stream "Life Will Always Finds A Way" Online
DISCONNECTED is a modern metal band drawing influences from Gojira, Deftones, and Alter Bridge.
They released their debut album White Colossus in March 2018 through indie record label Apathia Records on all major streaming platforms with physical releases in Europe and Japan.
After playing numerous gigs in France they opened for Tremonti on his 2018 European tour playing a further 24 shows across 17 countries. This expanded the European fan base notably in the UK, Germany and France.
After being noticed by Drouot Production and Ossy Hoppe of Wizard Promotion, the band were invited to open for Judas Priest in January 2019 (Zenith of Paris). Disconnected also supported Mass Hysteria in March and November 2019.
The band will also be playing Rock Fest 2022 (postponed edition of 2020) in Barcelona, Wacken.
OpenAir 2022 (postponed edition of 2020) in Germany, and festival of Cabaret Vert 2022 (postponed edition of 2020).
They recorded their second album and plan on releasing it in the first half of 2022.
Previous to this they released a first excerpt : "UNSTOPPABLE" the 10th of April 2020 with already more than 950,000 streams on Spotify, and more than 100,000 views on the music vid (Facebook and YouTube views combined)
As the pandemic hit in 2020 and almost every live events was being postponed to 2022 they decided to work on an EP to offer their fans some new to listen to in 2021.
THE DOWNTIME is out since the 14th of May 2021 and only available on digital platforms. (Distributed by Le Pool).
RECENTLY, DISCONNECTED HAS BEEN ADDED ON THE HISTORICAL LINEUP OF HELLFEST 2022 (MAINSTAGE) ALONGSIDE WITH BANDS SUCHAS GUNS'N'ROSES, METALLICA, MEGADETH, ALICE COOPER, and NIN .
Connect with DISCONNECTED:
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The Wholesale Forums (or TWF) is the UK's leading networking wholesale forum marketplace, community & independent advice forum for trade buyers and suppliers. We're on a mission to change the way our industry connects with each other by building a networking and engaging community.
What started as a fledgling idea back in July 2004 has matured to become an essential source of information, advice and networking for over 200,000 members across the globe.
Commerce is the transfer of ownership of goods and services from one person or entity to another, a network that facilitates this is often called a market. Between that we believe an ecosystem exists where everything leading up to a transaction tends to get completed. As an online community, we have embedded ourselves within that ecosystem and we exist to serve as an essential source of information, advice and networking for trade buyers and suppliers from across the globe.
Anthony Trollope, then CEO wanted to change the way trade buyers and suppliers networked with each other, thus developing The Wholesale Forums in 2004 to the launch in 2005.
The Wholesale Forums then CEO, Anthony Trollope, completed his studies and went full time opening TWF offices in West London.
Having employed people back in 2010, The Wholesale Forums active community membership did exceptionally well and reached over the 100,000 threshold.
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Anthony Trollope handed The Wholesale Forums over to new CEO, Helen Parker.
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The Wholesale Forums undergoes major development work, with the re-introduction of Member of the month and our newest feature Advertising Directory.
The company was founded in 2004 to change the way trade buyers and suppliers network with each other online – the founder Anthony Trollope was selling on eBay and saw the need for a place to allow people to trade and share expertise and news. The company has grown exponentially since then and is now located in Leatherhead, Surrey and run by our Community Manager Cody Stallard - who loves all things forum, online and trade. The team have a massive experience in trade and online, and work tirelessly to ensure the community continues to be the welcoming, informative and successful place it has been for the past 13 years.
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text:
Dexamethasone promotes long-term functional recovery of neuromuscular junction in a murine model of tourniquet-induced ischaemia–reperfusion
D. Zhang, D. Wang, I. I. Pipinos, R. L. Muelleman, Y. L. Li
Ophthalmology and Visual Sciences
Orthopaedic Surgery & Rehabilitation
Fred & Pamela Buffett Cancer Center
Great Plains IDeA-CTR
Cellular & Integrative Physiology
Vascular Surgery, Nebraska Medicine
Emergency Department, Nebraska Medicine
Aim: Tourniquet-induced ischaemia and subsequent reperfusion cause serious ischaemia–reperfusion (IR) injury in the neuromuscular junction (NMJ) and skeletal muscle. Here, we investigated whether dexamethasone (Dex) promotes long-term functional recovery of the NMJ and skeletal muscle in tourniquet-induced hindlimb IR. Methods: Unilateral hindlimb of C57/BL6 mice was subjected to 3 h of ischaemia following 6 weeks of reperfusion (6-wk IR). Dex treatment began on the day of IR induction and lasted for different periods. Sciatic nerve-stimulated gastrocnemius muscle contraction was detected in situ. Function of the NMJ was measured in situ using electrophysiological recording of the miniature endplate potential (mEPP) and endplate potential (EPP). Western blot was used to detect protein expression of nicotinic acetylcholine receptors (nAChRs) in gastrocnemius muscles. Results: Gastrocnemius muscle contraction in mice with 6-wk IR was about 60% of normal skeletal muscle contraction recorded in age-matched sham mice. The amplitude of the mEPP and EPP was lower in mice with 6-wk IR, compared to sham mice. Dex treatment for 1 or 3 days did not restore the function of the NMJ and improve gastrocnemius muscle contraction in mice with 6-wk IR. Dex treatment for 1 week exerted a maximum effect on improving the function of the NMJ and skeletal muscle, with the effect of Dex gradually lessening with prolonged Dex treatment. There are no significant differences in protein expression of nAChR-α1 and nAChR-β1 subunits in the gastrocnemius muscle among all groups. Conclusion: Dex promotes repair of the NMJ and subsequently restores skeletal muscle contractile function in tourniquet-induced 6-wk IR.
Acta Physiologica
https://doi.org/10.1111/apha.12737
endplate potential
ischaemia–reperfusion injury
neuromuscular junction
10.1111/apha.12737
Dive into the research topics of 'Dexamethasone promotes long-term functional recovery of neuromuscular junction in a murine model of tourniquet-induced ischaemia–reperfusion'. Together they form a unique fingerprint.
Tourniquets Medicine & Life Sciences 100%
Neuromuscular Junction Medicine & Life Sciences 92%
Skeletal Muscle Medicine & Life Sciences 62%
Muscle Contraction Medicine & Life Sciences 32%
Hindlimb Medicine & Life Sciences 17%
Zhang, D., Wang, D., Pipinos, I. I., Muelleman, R. L., & Li, Y. L. (2017). Dexamethasone promotes long-term functional recovery of neuromuscular junction in a murine model of tourniquet-induced ischaemia–reperfusion. Acta Physiologica, 219(2), 453-464. https://doi.org/10.1111/apha.12737
Dexamethasone promotes long-term functional recovery of neuromuscular junction in a murine model of tourniquet-induced ischaemia–reperfusion. / Zhang, D.; Wang, D.; Pipinos, I. I. et al.
In: Acta Physiologica, Vol. 219, No. 2, 01.02.2017, p. 453-464.
Zhang, D, Wang, D, Pipinos, II, Muelleman, RL & Li, YL 2017, 'Dexamethasone promotes long-term functional recovery of neuromuscular junction in a murine model of tourniquet-induced ischaemia–reperfusion', Acta Physiologica, vol. 219, no. 2, pp. 453-464. https://doi.org/10.1111/apha.12737
Zhang D, Wang D, Pipinos II, Muelleman RL, Li YL. Dexamethasone promotes long-term functional recovery of neuromuscular junction in a murine model of tourniquet-induced ischaemia–reperfusion. Acta Physiologica. 2017 Feb 1;219(2):453-464. doi: 10.1111/apha.12737
Zhang, D. ; Wang, D. ; Pipinos, I. I. et al. / Dexamethasone promotes long-term functional recovery of neuromuscular junction in a murine model of tourniquet-induced ischaemia–reperfusion. In: Acta Physiologica. 2017 ; Vol. 219, No. 2. pp. 453-464.
@article{5665318def404d9c9312bb63a613fe75,
title = "Dexamethasone promotes long-term functional recovery of neuromuscular junction in a murine model of tourniquet-induced ischaemia–reperfusion",
abstract = "Aim: Tourniquet-induced ischaemia and subsequent reperfusion cause serious ischaemia–reperfusion (IR) injury in the neuromuscular junction (NMJ) and skeletal muscle. Here, we investigated whether dexamethasone (Dex) promotes long-term functional recovery of the NMJ and skeletal muscle in tourniquet-induced hindlimb IR. Methods: Unilateral hindlimb of C57/BL6 mice was subjected to 3 h of ischaemia following 6 weeks of reperfusion (6-wk IR). Dex treatment began on the day of IR induction and lasted for different periods. Sciatic nerve-stimulated gastrocnemius muscle contraction was detected in situ. Function of the NMJ was measured in situ using electrophysiological recording of the miniature endplate potential (mEPP) and endplate potential (EPP). Western blot was used to detect protein expression of nicotinic acetylcholine receptors (nAChRs) in gastrocnemius muscles. Results: Gastrocnemius muscle contraction in mice with 6-wk IR was about 60% of normal skeletal muscle contraction recorded in age-matched sham mice. The amplitude of the mEPP and EPP was lower in mice with 6-wk IR, compared to sham mice. Dex treatment for 1 or 3 days did not restore the function of the NMJ and improve gastrocnemius muscle contraction in mice with 6-wk IR. Dex treatment for 1 week exerted a maximum effect on improving the function of the NMJ and skeletal muscle, with the effect of Dex gradually lessening with prolonged Dex treatment. There are no significant differences in protein expression of nAChR-α1 and nAChR-β1 subunits in the gastrocnemius muscle among all groups. Conclusion: Dex promotes repair of the NMJ and subsequently restores skeletal muscle contractile function in tourniquet-induced 6-wk IR.",
keywords = "dexamethasone, endplate potential, ischaemia–reperfusion injury, neuromuscular junction, skeletal muscle, tourniquet",
author = "D. Zhang and D. Wang and Pipinos, {I. I.} and Muelleman, {R. L.} and Li, {Y. L.}",
note = "Publisher Copyright: {\textcopyright} 2016 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd",
doi = "10.1111/apha.12737",
journal = "Acta Physiologica",
T1 - Dexamethasone promotes long-term functional recovery of neuromuscular junction in a murine model of tourniquet-induced ischaemia–reperfusion
AU - Zhang, D.
AU - Wang, D.
AU - Pipinos, I. I.
AU - Muelleman, R. L.
AU - Li, Y. L.
N1 - Publisher Copyright: © 2016 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd
N2 - Aim: Tourniquet-induced ischaemia and subsequent reperfusion cause serious ischaemia–reperfusion (IR) injury in the neuromuscular junction (NMJ) and skeletal muscle. Here, we investigated whether dexamethasone (Dex) promotes long-term functional recovery of the NMJ and skeletal muscle in tourniquet-induced hindlimb IR. Methods: Unilateral hindlimb of C57/BL6 mice was subjected to 3 h of ischaemia following 6 weeks of reperfusion (6-wk IR). Dex treatment began on the day of IR induction and lasted for different periods. Sciatic nerve-stimulated gastrocnemius muscle contraction was detected in situ. Function of the NMJ was measured in situ using electrophysiological recording of the miniature endplate potential (mEPP) and endplate potential (EPP). Western blot was used to detect protein expression of nicotinic acetylcholine receptors (nAChRs) in gastrocnemius muscles. Results: Gastrocnemius muscle contraction in mice with 6-wk IR was about 60% of normal skeletal muscle contraction recorded in age-matched sham mice. The amplitude of the mEPP and EPP was lower in mice with 6-wk IR, compared to sham mice. Dex treatment for 1 or 3 days did not restore the function of the NMJ and improve gastrocnemius muscle contraction in mice with 6-wk IR. Dex treatment for 1 week exerted a maximum effect on improving the function of the NMJ and skeletal muscle, with the effect of Dex gradually lessening with prolonged Dex treatment. There are no significant differences in protein expression of nAChR-α1 and nAChR-β1 subunits in the gastrocnemius muscle among all groups. Conclusion: Dex promotes repair of the NMJ and subsequently restores skeletal muscle contractile function in tourniquet-induced 6-wk IR.
AB - Aim: Tourniquet-induced ischaemia and subsequent reperfusion cause serious ischaemia–reperfusion (IR) injury in the neuromuscular junction (NMJ) and skeletal muscle. Here, we investigated whether dexamethasone (Dex) promotes long-term functional recovery of the NMJ and skeletal muscle in tourniquet-induced hindlimb IR. Methods: Unilateral hindlimb of C57/BL6 mice was subjected to 3 h of ischaemia following 6 weeks of reperfusion (6-wk IR). Dex treatment began on the day of IR induction and lasted for different periods. Sciatic nerve-stimulated gastrocnemius muscle contraction was detected in situ. Function of the NMJ was measured in situ using electrophysiological recording of the miniature endplate potential (mEPP) and endplate potential (EPP). Western blot was used to detect protein expression of nicotinic acetylcholine receptors (nAChRs) in gastrocnemius muscles. Results: Gastrocnemius muscle contraction in mice with 6-wk IR was about 60% of normal skeletal muscle contraction recorded in age-matched sham mice. The amplitude of the mEPP and EPP was lower in mice with 6-wk IR, compared to sham mice. Dex treatment for 1 or 3 days did not restore the function of the NMJ and improve gastrocnemius muscle contraction in mice with 6-wk IR. Dex treatment for 1 week exerted a maximum effect on improving the function of the NMJ and skeletal muscle, with the effect of Dex gradually lessening with prolonged Dex treatment. There are no significant differences in protein expression of nAChR-α1 and nAChR-β1 subunits in the gastrocnemius muscle among all groups. Conclusion: Dex promotes repair of the NMJ and subsequently restores skeletal muscle contractile function in tourniquet-induced 6-wk IR.
KW - dexamethasone
KW - endplate potential
KW - ischaemia–reperfusion injury
KW - neuromuscular junction
KW - skeletal muscle
KW - tourniquet
U2 - 10.1111/apha.12737
DO - 10.1111/apha.12737
JO - Acta Physiologica
JF - Acta Physiologica


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