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Sandra Marchetti's The Canopy, a Review
The Canopy by Sandra Marchetti
2012, Midwest Writing Center Press, Davenport, IA
Paperback, 27 pages, $8
Reviewed by Kirsten Clodfelter
Sandra Marchetti's The Canopy, which she's divided into four succinct and effortlessly readable sections, opens with the heavy-hitter "Pastoral." This poem sets the tone of her debut chapbook and serves as a smart meta-interpretation of Marchetti's approach to the poetry that spans these 27 pages and, more significantly, the writing process she's used to craft it. I crunch my boots in for respite, she writes, survey the scape where the year's poems were written….
Marchetti approaches language cleverly and playfully in her work. Here, the word scape calls to mind both landscape and escape, and the author at once inhabits the role of surveyor and the role of someone seeking a way out. She artfully holds the balance between these two overlapping personas, between her ownership of and power over her environment and the way she must work to avoid succumbing to it.
Marchetti is able to use her temporary moments of captivity to transition the reader seamlessly into the wild terrain of her imagination, where she can always find freedom. In this space, Marchetti views even the most seemingly insignificant details around her through a microscopic lens, blowing up these tiny actions or images or thoughts until we're shifted beyond them into the metaphysical, into a fresh space where she is in charge.
For a moment, readers may feel anxious as Marchetti recounts in "Pastoral," I stand wrung-up, by feet/ fixed in their mush-spots; cold's tight arrow/ plunges my chest. But then there is a turn, a device we see employed successfully again and again in Marchetti's tight, controlled writing, a moment when, by the next line, she has reclaimed her power with her exacting language, writing, This is why I go out,/ I think; it is something to recover from.
In owning her experiences with the world she encounters, Marchetti guides readers through the unique and magical vision of her surroundings. With her, we see A snow machine's/ owl-lit eyes, the falling snow as skirts of white swaying/ earthward. Over and over Marchetti surprises us with the astounding and arresting beauty she finds in her quiet day-to-day movements, in actions as simple and ordinary as going for a walk, eating an apple, or taking a bath with her husband.
Marchetti transforms these tiny details into something grand, something truly lovely for the reader to behold and perhaps to see again, for the first time, from this new perspective. In "Cold dark deep and absolutely clear," we imagine with Marchetti that June is a sliver/ of wet movement, an arc that asks for colors/ to ice it hotly and shake the shake of gray. In "Silver," we witness Marchetti in bed with her lover, her skin a new bird/ white in the morning-bright/ and newly downy, but even as she discovers herself bound to these moments of inexperience, her language is articulated with force and confidence. Marchetti easily convinces us that she's someone who knows what she's talking about, that she's someone we should listen to.
Marchetti's word play continues in the second section of this collection, where she draws the reader in with the musical ease of her language in the powerful "Le Parc des Suicides." This poem exemplifies Marchetti's finest balance between the human struggle of maintaining some type of control over our environment and the danger of being consumed by it.
The piece opens with the image of heron and a bridge used for suicide. In the first three stanzas, we see the jumper among the birds, first chasing the heron and then even becoming like the heron with a human's perch; finally, the narrator transforms and is gifted with momentary flight at the instant of jumping. This action is met (here, again, in a carefully constructed turn) with the aftermath of that fall, the body, no longer heron-like at all, now given to granite,/ carved into a willing water, and later, [f]leshed/ against the sidewalls/ of underwater blood canyons. By the end, what's physically left of this poem's narrator has cycled into sustenance for the birds, this is the heron's/ pick-ground. For those few minutes before the jump, there is a last moment of intentionality, of ownership. After the jump, the narrator has succumbed to their environment, seeking the ultimate escape. The struggle is ever-present, and Marchetti captures it expertly.
Even indoors, in a place as quiet and safe as the bedroom, Marchetti writes compellingly about how truly complex our interactions with our own territory can be. In "Fissures" she explains, My body… / lies on the bed in its bones/ and curls of hair, and here we see the author at her most vulnerable, struggling to shift the balance of power back into her own favor, to find control, even as she tells us, I lay and am unhitched,/ unrolled. Yet at the close of the book, we see Marchetti as the thoughtful victor, someone who is unafraid of what she still has to learn from the details around her as she moves toward self-assuredness, someone who, a step at a time, is claiming her place, someone we need to pay attention to. Everywhere is sharp edges/ even outside rooms, Marchetti writes, I am attempting to see. We should look with her.
Guide to the Guides: Spunk and Bite
Imaging Figures #3

redpajama_set_name: RedPajamaCommonCrawl


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0800 917 1000 Open weekdays 9am-5pm
IICSA Independent Inquiry into Child Sexual Abuse
Interim Report
Victims and survivors' accounts
2. Overview of the Inquiry
2.1 The Truth Project
2.2 Investigations and public hearings
2.4 Seminars and engagement
2.5 Review of previous reports and investigations
2.6 Operation Hydrant
3. The nature and effects of child sexual abuse
4. Institutional responses to child sexual abuse investigation
5. Current practice to tackle child sexual abuse
6. Emerging themes
7. List of recommendations
8. The Inquiry's work programme for 2018-19
Annex A: Update on investigations
Annex B: Update on research projects
Appendix 1: Child migration programmes: Case study report
Appendix 2: Cambridge House, Knowl View and Rochdale: Investigation report
Back to IICSA.org.uk
The Inquiry's Terms of Reference require it to:
consider all the information which is available from the various published and unpublished reviews, court cases, and investigations which have so far concluded.
As a result, the Inquiry is considering what can be learned from the range of reviews and investigations that have preceded it. Part of this work has involved reviewing the recommendations from a number of previous public reports and investigations into child sexual abuse to identify whether there are consistent issues arising that should inform the Inquiry's work. In total, 211 reviews and reports ‒ containing 3,004 recommendations ‒ have been analysed.
The Inquiry has organised the recommendations made by these reports into a number of thematic areas (Table 1) to assist the Inquiry in identifying key issues that have arisen in previous reports and reviews. It is notable that the most frequently recurring issues have also arisen regularly in other parts of the Inquiry's work and are discussed in Chapter 6 of this report: the need for a culture change in relation to attitudes towards child sexual abuse, the role of leadership in supporting this culture change, and issues relating to staff practice and safe recruitment.
Table 1 Categorisation of recommendations in the review of previous reports and investigations
Recommendation areas
Number of recommendations
Staffing (including practice, supervision and recruitment) 826 (27.5%)
Records management systems and processes (including information sharing) 501 (16.7%)
Failures, issues and attitudes in working or supporting children and/or victims and survivors 413 (13.7%)
Leadership and oversight 396 (13.2%)
Inter-agency working 318 (10.6%)
Other recommendations (including operational policy and procedure, and complaints) 550 (18.3%)
The Inquiry is considering whether the recommendations made in previous reports and investigations about child sexual abuse have been implemented as part of the 'Child sexual exploitation by organised networks' investigation.
Download summary report (PDF 506.46 KB)
Lawrlwythwch adroddiad cryno (PDF 491.05 KB)
Download full report (PDF 1.55 MB)
Lawrlwythwch yr adroddiad llawn (PDF 1.66 MB)
IICSA Truth Project
Follow IICSA on Twitter
View the IICSA YouTube Channel


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Advising Families .
Our People .
Cycle of Wealth
Every family is strengthened by having a shared goal for the family's wealth and agreeing upon a set of values, which all generations wish to exhibit and live by.
Many families who successfully transition wealth through multiple generations have a unique set of values, which express their world-view and the principles which family members choose to embody. When a family has the courage to examine the qualities it wishes to uphold, the process is unifying and deeply fulfilling for all members of the family across all generations.
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A 21st Century Approach to Family Values
Families often make a common and critical mistake when determining their family values.
Let's look at how families typically think about "Family Values".
Concerns about transitioning family wealth have traditionally revolved around two core topics, Disposition and Timing: "What will be done with the wealth?" and "When will the heirs come to control the wealth?"
In recent decades, we have seen the emergence of what has come to be known as "Values-Based Estate Planning", which seeks to ensure that when the wealth is transferred, the heirs manage their inheritance in accordance with a set of values, which will prevent them from squandering the family's fortune.
This process typically consists of conversations with the patriarch and matriarch, to determine a set of principles and standards, which are then integrated into Estate documents, in order to ensure their heirs act in a "right and proper" manner in relation to their inheritance.
Unfortunately, this process frequently breaks down and leads to conflict.
Why? The process of Values-Based Estate Planning leads to heirs feeling trapped by a structured framework, upon which they were never consulted. It accounts for the large numbers of heirs who seek to break the shackles of their trustee relationships through litigious means.
A 21st century approach to Estate Planning begins by creating a compact across generations, whereby the whole family organises themselves around a shared long-term goal. In families, unlike in business, "long term" equates to at least three to four generations or 100 years. The family will agree on how they wish to reach decisions together as the family grows in size. They will consider whether wealth transitions per stirpes or per capita. Most importantly, however, once the family have agreed on their shared long-term goal across the generations, they will agree on a common set of values which they all subscribe to and which binds them together.
This process enables a family to resolve underlying issues and tensions, which might cause conflict at a later date. More importantly, our approach is specifically designed to create real affinity between family members across generations.
When family values are defined in this context, they establish a framework of common understanding and co-operation which can last for generations.
For a detailed description of this process, please see: Family Legacy.


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Home Season Preview Potent offense sparks Minnesota-Duluth's high expectations
Potent offense sparks Minnesota-Duluth's high expectations
The pieces are in place for Minnesota-Duluth to meet expectations and finish near the top of the WCHA standings in 2010-11.
The Bulldogs return three 40-plus-point scorers — Jack Connolly, Mike Connolly and Justin Fontaine — that anchored a UMD power play that ranked third in Division I at the end of last season.
The media picked the Bulldogs to finish second in the WCHA, while the coaches projected them to take third.
"I like our chances to continue performing at a high level on the power play with the personnel we're bringing back," Minnesota-Duluth coach Scott Sandelin said in a press release. "We probably have more players, both forwards and defensemen, who are capable of seeing power-play time than we ever have."
On Dec. 30, the Bulldogs will move into the new, $70 million Amsoil Arena to replace the Duluth Entertainment Convention Center, which the Bulldogs called home for 44 years.
Fontaine and the Connollys will undoubtedly be counted on to score a bulk of UMD's goals this year after the type of seasons they had in 2009-10.
Jack Connolly was the Bulldogs' overall points leader with 49 and led the team in assists (31) to go with his 18 goals. WCHA coaches voted him the conference's preseason player of the year.
Fontaine led the Bulldogs in goals with 21, finishing with 46 points. Mike Connolly finished the season with 14 goals and 40 points.
"Travis Oleksuk is another guy we'll need production from to try and take some pressure off our big three," Sandelin said. "Our opponents are going to focus on them, but we have some other capable players."
The Bulldogs will miss 40-point scorer Rob Bordson, who left Duluth after his junior season.
On the blue line
Sandelin expects Justin Faulk to have an impact on the Bulldogs' blue line this season after scoring 33 points for the U.S. National Under-18 Team last season. He also helped Team USA win the IIHF U18 World Championship gold medal.
"Justin Faulk comes in as a very talented, highly touted player who has obviously played at a high level with the National Team Development Program the past two winters," Sandelin said. "He brings an element of offense to his game, but can also play tough if need be."
Brady Lamb was UMD's top scoring defenseman from last season with 24 points.
Kenny Reiter split time in net with Brady Hjelle last season, with Reiter starting the majority of the games. Reiter had better numbers with a 2.37 goals-against average and a .912 save percentage.
Hjelle returned to the USHL in the offseason.
Previous articleMinnesota State looks to go farther after late-season setbacks
Next articleBemidji State seeks same results in new league, arena
NEHC Preview: Norwich seeking to repeat championship run
UCHC Preview: Utica expecting a tight conference race
MIAC Preview: Augsburg seeking fifth consecutive title


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text:
// --------------------------------------------------------------------------------------------------------------------
// <copyright file="WaitForTrackingCodesToBeInStatusMessage.cs" company="Naos Project">
//    Copyright (c) Naos Project 2019. All rights reserved.
// </copyright>
// --------------------------------------------------------------------------------------------------------------------

namespace Naos.MessageBus.Domain
{
    using System;

    /// <summary>
    /// Message to wait for tracking codes to be in a set of statuses.
    /// </summary>
    public class WaitForTrackingCodesToBeInStatusMessage : IMessage, IShareTrackingCodes
    {
        /// <inheritdoc />
        public string Description { get; set; }

        /// <inheritdoc />
        public TrackingCode[] TrackingCodes { get; set; }

        /// <summary>
        /// Gets or sets the statuses that are being waited for.
        /// </summary>
        [System.Diagnostics.CodeAnalysis.SuppressMessage("Microsoft.Performance", "CA1819:PropertiesShouldNotReturnArrays", Justification = "Keeping this way for now.")]
        public ParcelStatus[] AllowedStatuses { get; set; }

        /// <summary>
        /// Gets or sets the wait time between checks on status.
        /// </summary>
        public TimeSpan WaitTimeBetweenChecks { get; set; }
    }
}

redpajama_set_name: RedPajamaGithub


text:
Post Tagged with: "US News rankings"
Geisel Continues to Rank Among Nation's Top Medical Schools
The Geisel School of Medicine at Dartmouth rose in the most recent U.S. News & World Report Best Medical School rankings.
Geisel Rises in U.S. News Best Medical Schools Rankings to Top 20 in Primary Care
by Geisel Communications in Press Release
The Geisel School of Medicine at Dartmouth has moved into the top 20 of medical schools nationally for primary care, climbing 13 spots to 18th in the 2015 U.S. News & World Report's Best Medical Schools rankings. Geisel also moved up four spots to 34th in the Best Medical Schools for research ranking.


text:
Defunct street lights? Don't expect SMC to fix them
Fatima Riyaz | 2 Mins Read
Srinagar, Jun 17: Srinagar plunges into darkness soon after sunset as most of the street lights in the capital city are defunct.
This being so since Srinagar Municipal Corporation (SMC) claims it is incapable to deal with the issue.
In absence of this basic facility, the city residents face a lot of inconvenience moving out of their homes to the markets or masjids during the evening and early morning hours.
Cases of burglary and dog-bites have been reported from many secluded areas where residents complain of either having defunct or no street lights.
People living in many of these poorly-lit areas feel scared to venture out of their homes in late hours.
"I prefer not to leave my home after Isha namaz. Dogs chase passersby since there is no street light in this colony," said Bashir Ahmed, 60, a resident of Illahibagh.
SMC claims it has installed more than 40,000 street lights across the city. However, majority of them remain dysfunctional due to lack of an established electric division and less technical manpower in the corporation.
Executive Engineer SMC, Qazi Imtiyaz who looks after the Mechanical division, said: "We have nothing. Zero manpower to look after the technical faults of street lights. There is no electric division in our corporation."
SMC Commissioner, Khursheed Ahmad Sanai said: "SMC lacks an established electric division as well as skilled staff to mend defunct street lights in Srinagar. But we are constantly making up to illuminate more areas through whatever little staff is available to us."
Mid-Day Meal transferred to PRIs
RKFC signs top English striker
Fatima Riyaz
Nisar Dharma
Srinagar, Jul 19: Five districts in Jammu and Kashmir do not have the facility of blood banks thus presenting the sorry state of basic health infrastructure in the state.
The information was Friday revealed by Union Minister of State for Health Ashwini Kumar Choubey in a written reply to Rajya Sabha.
The five districts – Bandipora, Ganderbal, Shopian, Samba, Reasi – share the poor record with 76 others in India.
As per Government of India policy, each district has to have at least one blood bank.
"Public Health, being a State subject, it is the primary responsibility of the State Government to ensure the establishment of Blood Banks as per their need," the Minister said in his reply.
Lack of blood banks can be the deciding factor between a person's life and death especially in J&K, which witnesses freak road accidents now and then killing more people in the state than the political conflict.
Such is the paucity of blood that the attendants of patients admitted at tertiary care hospitals in Srinagar have to, at times, resort to crowd-sourcing asking people to donate blood at the eleventh hour.
Like J&K, Meghalaya and Bihar too don't have blood banks in at least five districts, followed by Telangana, Assam, Chhattisgarh, and Jharkhand respectively, wherein there are no blood banks in four districts each.
The northeastern state of Arunachal Pradesh tops the list with 14 districts of not having blood banks. This was followed by Manipur wherein 12 districts, and Nagaland wherein nine districts do not have blood banks.
A total of 3,108 licensed blood banks are established in the country, with Maharashtra being on top with 333 blood banks, followed by Uttar Pradesh with 327 blood banks in the state.
In Gujarat, there are 153 blood banks and the national capital Delhi has 60 blood banks.
Kashmir News Service
Srinagar, Jul 19: Unidentified gunmen Friday afternoon shot dead a Personal Security Officer (PSO) of Peoples Democratic Party (PDP) leader and Mehbooba Mufti's cousin brother Sajad Mufti outside the shrine in Baba Mohalla area of Bijbehara in South Kashmir's Anantnag district.
The slain cop was identified as Constable Farooq Ahmad of Dirpora Khiram. A police official said that he was attacked by militants at Ziyarat Baba Naseer-ud-din Gazi in Bijbehara during Friday prayers.
Farooq was standing guard outside the shrine when he was shot dead by the gunmen.
The former chief Minister's cousin brother was offering prayers in Masjid at the shrine when his PSO was shot dead.
The cop was immediately rushed to the Sub District Hospital Bijbehara for treatment where doctors declared him dead on arrival.
Reports said the gunmen also decamped with the service rifle of Ahmad.
Meanwhile, police paid tributes to the slain cop and expressed solidarity with his bereaved family. "We stand by his family at this critical juncture," Kashmir Zone Police said in a tweet.
The wreath laying ceremony for the slain cop was held at District police Line (DPL) Anantnag.
Police officers led by Inspector General of Police (IGP) Kashmir, Swayam Prakash Pani laid floral wreaths on his mortal remains and paid tributes to the cop. (KNS)
Senior police officers including IGP Kashmir, SP Pani, DIG SKR, SSP Anantnag and other officers from CAPF laid floral wreaths on the mortal remains and paid rich tributes to the slain cop.
Farooq is survived by old aged father, brother, wife, 12 years old son Mohsin Farooq, seven year old Faisal and two year old Zaid Farooq.
"We pay our rich tributes to the martyr for his supreme sacrifice made in the line of duty. We stand by his family at this crucial juncture," a police spokesperson said.
Srinagar, Jul 19: Police Friday said it has arrested three individuals involved in physically abusing a minor girl inside Dal Lake.
A police spokesperson said that police Station Nigeen received a complaint that a minor girl has been physically abused inside Dal Lake in Hazratbal area.
"Consequently Case FIR No. 65/2019 under relevant sections of law was registered in Police Station Nigeen and investigation was initiated," the spokesperson said.
During the course of investigation, the spokesperson said, police arrested two persons identified as Tawheed Ahmad Mir son of Showkat Ahmad Mir and Ehsan-ul-haq son of Showkat Ahmad Yatoo both residents of Sadrabal.
However, the third accused managed to escape taking advantage of deep waters, police added.
"A special team under the supervision of SP Hazratbal arrested third person after strenuous efforts. He has been identified as Bilal Ahmad Dar alias Kila son of Ghulam Nabi Dar resident of Dargah. The prompt action of police and the arrest of all the three accused in the heinous crime within 24hrs was appreciated by the community members," the spokesperson added.


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2019, Grand View College, Avogadro's review: "Purchase Extra Super Cialis online in USA - Best online Extra Super Cialis OTC".
Typical plaque- like lesions disappear buy generic extra super cialis 100 mg line, the skin is universally red and scaly and the condition is known as erythrodermic psoriasis cheap generic extra super cialis canada. Patients who are seriously ill suffer from: ● heat loss buy extra super cialis 100 mg low price, and are in danger of hypothermia because of the increased blood supply to the skin ● water loss, leading to dehydration because of the disturbed barrier function of the abnormal stratum corneum ● a hyperdynamic circulation, because effectively there is a vascular shunt in the skin; when the patient's myocardium is already compromised because of other factors, there is a danger of high output failure ● loss of protein, electrolytes and metabolites via the shed scales and exudates; patients may develop deficiency states. Pustular psoriasis Most dermatologists consider this to be a manifestation of psoriasis, although there are some who believe it is a separate disorder. It seems probable that pustu- lar psoriasis is indeed a type of psoriasis, with exaggeration of one particular com- ponent of the disease (see Pathology below). Palmoplantar pustulosis Patients with palmoplantar pustulosis develop yellowish white, sterile pustules on the central parts of the palms and soles (Figs 9. Older lesions take on a brownish appearance and are later shed in a scale at the surface. The affected area can become generally inflamed, scaly and fissured and, although relatively small areas of skin are affected, the condition can be very disabling. The disorder tends to be resistant to treatment (see below) and is subject to relapses and remission over many years. Generalized pustular psoriasis This is also known eponymously as Von Zumbusch disease, and is one of the most serious disorders dealt with by dermatologists. In its classical form, attacks occur suddenly and are characterized by severe systemic upset, a swinging pyrexia, arthralgia and a high polymorphonuclear leucocytosis accompanying the skin disorder. The skin first becomes erythrodermic and then develops sheets of sterile pus- tules over the trunk and limbs (Fig. Sometimes, the pustules become confluent so that 'lakes of pus' develop just beneath the skin surface. In other areas, there is a curious type of superficial peel- ing without pustules forming. They can usually be brought into remission by modern treatments (see below), but are subject to recurrent attacks. Other forms of pustular psoriasis Occasionally, pustules may develop after strong topical or systemic corticosteroids have been used and then abruptly withdrawn. Other rare variants of pustular psor- iasis include: ● acrodermatitis continua, in which there is a recalcitrant pustular erosive dis- order on the fingers and toes around the nails and occasionally elsewhere ● pustular bacterid, in which sterile pustules suddenly appear on the palms, soles and distal parts of the limbs after an infection. Arthropathic psoriasis There is a higher prevalence of a rheumatoid-like arthritis with symmetrical involvement of the small joints of the hands and feet, wrists and ankles in patients with psoriasis (5–6 per cent) compared to a matched control population (1–2 per cent). This 'rheumatoid arthritis-like' disorder differs in one important respect from ordinary rheumatoid arthritis – there is no circulating rheumatoid factor. In addition, there is a distinctive and destructive form of joint disease that seems specific to psoriasis. In this 'psoriatic arthropathy', the distal interphalangeal joints, the posterior zygohypophysial, the temporomandibular and the sacroiliac 135 Psoriasis and lichen planus Figure 9. Bony erosion and destruction take place, leading to 'collapse' of affected digits (Fig. Treatment may temporarily improve these joint complications of psoriasis, but they tend to run a progressive course subject to remissions and relapses. The main features may be subdivided into (1) the epidermal thickening, (2) the inflam- matory component, and (3) the vascular component, but of course all are closely interlinked. The epidermal thickening The epidermis shows marked exaggeration of the rete pattern and elongation of the epidermal downgrowths with bulbous, club-like enlargement of their ends (Fig. The average thickness is increased from about three to four cells in the normal skin to approximately 12–15 cells in the psoriatic lesion. Many mitotic fig- ures can be seen and the rate of epidermal cell production seems to be greatly enhanced. The turnover time of psoriatic epidermis and stratum corneum is con- sequently very much shortened. Normally, it takes some 28 days for new cells to ascend from the basal layer and travel through the epidermis and the stratum corneum and reach the surface. Epidermal nuclei are retained in the inefficient horny layer that results (parakeratosis). The inflammatory component Interspersed between the 'parakeratotic' horn cells are collections of desiccated polymorphonuclear leucocytes known as Munro microabscesses. The dermis immedi- ately below the epidermis also contains many inflammatory cells, mostly lym- phocytes. In pustular psoriasis, the epidermal component is much less in evidence and there are collections of inflammatory cells within the epidermis (Fig. The vascular component The papillary capillaries are greatly dilated and tortuous to a degree not seen in other inflammatory skin disorders. Ultrastructurally it can be seen that there are larger gaps than usual between the endothelial cells. One very obvious abnormality in psoriasis is the hyperplastic epidermis with increased mitotic activity, and one line of intense investigation was directed at the control of epidermal cell production in this disease. Attention has moved away from this possibility in recent years and focused more on the 137 Psoriasis and lichen planus inflammation and possible immunopathogenesis. The disorder often responds to immunosuppressive agents such as cyclosporin and methotrexate and currently psoriasis is thought of as a 'lymphocyte-driven' disease. Various potentially heritable biochemical abnormalities have been suggested and/or described that could explain both the increased epidermal proliferation and the inflammatory component. At different times, alterations in the skin content or activity of cyclic nucleotides, polyamines, eicosanoids, cytokines and growth fac- tors have been described, but in most cases these changes are secondary to the underlying and fundamental less well-characterized events. Infection has been considered as a cause and in recent years the involvement of retroviruses has been suggested. Case 8 Jessie's mother and aunt had psoriasis and at the age of 19 Jessie thought that she was getting it too, as she had scaling patches on her knees and elbows and in her scalp. She also noticed some separation of the nail plates from the nail beds and pitting of three of her fingernails. The rash disappeared after 6 weeks, but unfortunately recurred the following year. In other patients, simple treatment with an emollient such as white soft paraffin, by itself or with 2 per cent salicylic acid, is sufficient when used once or twice daily. Tar-containing preparations are less popular than previously, but may suit some patients who can put up with the stinging, the unpleasant smell and the staining. Tar has anti-inflammatory and cytostatic activity and certainly has mild anti-psoriatic effect. Proprietary tar preparations have some advantages over the British National Formulary formulations. Used alongside medium-potency corticosteroids, the efficacy is increased and the skin imitation decreased. A preparation of calcipotriol formulated together with betamethasone-17-valerate is now available as 'Dovobet', and does appear quite effective. Tacalcitol is another vitamin D3 analogue, which, although effective when employed topically, is not as potent as calcipotriol.
Correlation between quantitative and qualitative burn wound biopsy culture and surface alginate swab culture buy generic extra super cialis. Comparative evaluation of surface swab and quantitative full thickness wound biopsy culture in burn patients order extra super cialis online now. Use of burn wound biopsies in the diagnosis and treatment of burn wound infection best purchase for extra super cialis. Correlation of culture with histopathology in fungal burn wound colonisation and infection. Frozen section technique to evaluate early burn wound biopsy: comparison with the rapid section technique. The Incidence of bacteremia following burn wound manipulation in the early post-burn period. Evaluation of white blood cell count, neutrophil percentage, and elevated temperature as predictors of bloodstream infection in burn patients. Enteral feeding intolerance: an indicator of sepsis associated mortality in burned children. The risk factors and time course of sepsis and organ dysfunction after burn trauma. Incidence, outcome, and long-term consequences of herpes simplex-virus type 1 reactivation presenting as a facial rash in intubated adult burn patients treated with acyclovir. Pneumonia in patients with severe burns; a classification according to the carrier state. A prospective study of hospital acquired infections in burn patients at a tertiary care referral centre in North India. Association between the presence of the Panton- Valentine leukocidin-encoding gene and a lower rate of survival among hospitalized pulmonary patients with staphylococcal disease. Catheter infection risk related to the distance between insertion site and burned area. Infections Related to Steroids in 22 Immunosuppressive/Immunomodulating Agents in Critical Care Lesley Ann Saketkoo and Luis R. Espinoza Section of Rheumatology, Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, U. Discussion will focus on complications of therapy in relation mainly to serious infections—defined as infection that is fatal, life threatening, or causing prolonged hospitalization. The use of biologic agents as they are newer therapies will be highlighted in the discussion. However, its use is fraught with a catalogue of damaging and disabling complications that will not be listed here. For this reason, it has been used as a bridge therapy during the time it takes for other less harmful therapeutics to take effect. The hospital-based physician needs to be aware of two potentially devastating complications in the management of the in-patient receiving exogenous corticosteroids: (i) hypothalamic suppression leading to adrenal insufficiency and (ii) risk of serious infection. Consensus in defining levels of immune suppression with glucocorticoid use is difficult to reach due to immunologic complexities inherent in underlying diseases being treated with corticosteroids as well as variances in patient sensitivity based on genetic make-up. But it is generally accepted that the degree of immune suppression increases with level of dosing and observation of physical changes such as cushingoid features, striae, and vascular friability. Level of dosing effecting immune response has been suggested through vaccine response studies and studies ascertaining infections as follows: l Daily prednisone of 10 mg (or its equivalent) or a greater or cumulative dose of 700 mg carried an increased relative risk of 1. Depending on the severity of the illness, glucocorticoids may indeed need to be supplemented to address hypothalamic stress caused by the illness itself. Decisions of hypothalamic support should be made on a case-by-case basis with decision-making between the critical care specialist, rheumatologist, infectious diseases specialist, and perhaps an endocrinologist. The effects of glucocorticoids on the immune system are several: l The appearance of increased white blood cell count is due to de-margination of leukocytes from the vascular endothelium. Nuclear factor kappa beta (key transcription factor) is prevented from attaching to the promoter regions of the genes expressing the above inflammatory agents. The risk of serious infection in the patient receiving exogenous corticosteroids is a real one. Due to steroid effects on innate and adaptive immunity, these patients may present in a very atypical manner with normal signals of the inflammatory response such as fever, itching, rash, or discrete pulmonary lesions, for example, being muted. Corticosteroids act further upstream in the body's immune response and more widely than most of the biologics listed below. Therefore, patients receiving moderate-to-high–dose steroids have been reported to be vulnerable to each of the microbial entities that are listed in the following section for biologic therapy. It is important to maintain a high level of suspicion and conduct a thorough investigation for the unusual suspects and have a low threshold to begin empiric therapy. Further susceptibility to infection is likely conferred by concomitant use of other immunosuppressive therapies, such as glucocorticoids and disease-modifying agents such as methotrexate, coexistent morbidities (3), age (4), and underlying immune dysfunction inherent to many autoimmune diseases (5). It is important to recognize that the patient numbers reflected here are small in comparison to the vast number of patients receiving biologic therapy. Until we understand better infectious disease patterns with the use of these agents, it is important to maintain a high index of suspicion for serious infection with both the usual and the unusual suspects presenting in usual and unusual ways. Very importantly, with signs or symptoms of potentially serious infection, biologic agents must be discontinued. We also advocate that with the exceptions of hydroxychloroquine and the presence of transplantation, all other immunosuppressants, such as methotrexate, mycophenolate, cyclosporine etc. Interference of immune cell migration and entry into sites of inflammation (alefacept, natalizumab) 4. It is a protein secreted by T cells, natural killer cells, and mast cells but mainly from activated mononuclear phagocytes in response to antigen presentation. It is recognized as important in stimulating macrophages, fibroblasts, and hematopoiesis in bone marrow. It is secreted by T cells, macrophages, and fibroblasts in response to tissue damage and presence of antigenic material. This is in use and under investigation for inflammatory bowel diseases, multiple sclerosis, psoriasis, and psoriatic arthritis. This signaling lies upstream of major cytokine expression and adaptive immunity mechanisms such as T- and B-cell proliferation and signaling. Lymphocytes may show repletion three weeks after therapy; however, depletion may last as long as one year. T-Cell activation and migration are targeted under several therapies with very different mechanisms of action. This co-stimulatory binding is 380 Saketkoo and Espinoza necessary for activation of T cells that directly impacts cytokine activation and B-cell proliferation. Greater than 50% of these cases were disseminated extrapulmonary disease with involvement of bone, bladder, meninges, and lymphoid tissue (12–14).
Identify additional cases Initial notification of an outbreak may come from a clinic or hospital; enquiries in health centres order generic extra super cialis from india, dispensaries and villages in the area may reveal other cases purchase extra super cialis 100 mg mastercard, sometimes with a range of additional symptoms order 100mg extra super cialis with visa. Overall or specific attack rates (age-specific village-specific) can then be calculated. These calculations may lead to new hypotheses requiring further investigation and development of study designs. Microbiological typing and susceptibility to antibiotics can then be used to develop appropriate control measures. Formulate a hypothesis as to source and spread of the outbreak Determine why the outbreak occurred when it did and what set the stage for its occurrence. Whenever possible the relevant conditions before the outbreak should be determined. For foodborne outbreaks it is neces- sary to determine source, vehicle, predisposing circumstances and portal of entry. All links in the process must be considered: i) disease-causing agent in the population and its characteristics; ii) existence of a reservoir; iii) mode of exit from this reservoir or source; iv) mode of transmission to the next host; v) mode of entry; vi) susceptibility of the host. Contain the outbreak The key to effective containment of an outbreak is a coordinated investigation and response involving health workers including clinicians, epidemiologists, microbiologists, health educators and the public health authority. The best way to ensure coordination may be to establish an outbreak containment committee early in the outbreak. Manage cases Health workers, including clinicians, must assume responsibility for treatment of diagnosed cases. In outbreaks of meningitis, plague or cholera, emergency accommodation may have to be found and additional staff may require rapid essential training. Outbreaks of diseases such as sleeping sickness and cholera may require special treatment and recourse to drugs not normally available. Outbreaks such as poliomyeli- tis may leave in their wake patients with an immediate need for physio- therapy and rehabilitation; timely organization of these services will lessen the impact of the outbreak. Implement control measures to prevent spread After the epidemiological characteristics of the outbreak have been better understood, it is possible to implement control measures to prevent further spread of the infectious agent. However, from the very beginning xxx of the investigation the investigative team must attempt to limit the spread and the occurrence of new cases. Immediate isolation of affected persons can prevent spread, and measures to prevent movement in or out of the affected area may be considered. Whatever the urgency of the control measures they must also be explained to the community at risk. Population willingness to report new cases, attend vaccination campaigns, improve standards of hygiene or other such activities is critical for successful containment. If supplies of vaccine or drugs are limited, it may be necessary to identify the groups at highest risk initial for control measures. Once these urgent measures have been put in place, it is necessary to initiate more perma- nent ones such as health education, improved water supply, vector control or improved food hygiene. It may be necessary to develop and implement long-term plans for continued vaccination after an initial campaign. Conduct ongoing disease surveillance During the acute phase of an outbreak it may be necessary to keep persons at risk (e. After the outbreak has initially been controlled, continued community surveillance may be needed in order to identify addi- tional cases and to complete containment. Sources of information for surveillance include: i) notifications of illness by health workers, community chiefs, employers, school teachers, heads of families; ii) certification of deaths by medical authorities; iii) data from other sources such as public health laboratories, entomological and veterinary services. It may be necessary to maintain estimates of the immune status of the population when immunization is part of control activities, by relating the amount of vaccine used to the estimated number of persons at risk, including newborns. Prepare a report A report should be prepared at intervals during containment if possible, and after the outbreak has been fully contained. Reports may be: i) a popular account for the general public so that they understand the nature of the outbreak and what is required of them to prevent spread or recurrence; ii) an account for planners in the Ministry of Health/local authority so as to ensure that the necessary administrative steps are taken to prevent recurrence: iii) a scientific report for publication in a medical journal or epidermiological bulletin (reports of recent outbreaks are valuable aids when teaching staff about outbreak control). For example, it may be necessary to show that sliced foodstuffs can be contaminated by an infected slicing machine if this has not been proven during the outbreak investigation. Such verification requires more laboratory facilities than are available in the field, and is often not completed until long after the outbreak has been contained. The response will of necessity involve the intelligence com- munity and law enforcement agencies as well as public health services, and possibly the Defence Ministry as well, especially if the event is considered of non-domestic origin. Difficulties in communication and approaches may arise, since these disciplines do not usually work to- gether. The public health response included identifying all those at risk of infection through the postal system, and prescribing antibiotics to over 32 000 persons identified as potentially in contact with envelopes contaminated with anthrax spores. The event and associated hoaxes caused unprecedented demands on public health laboratory services, and several nations had to recruit private laboratories to deal with the overflow. If the agent is widely dispersed and/or easily transmissible, a surge capacity may be required to accommodate large numbers of patients, and systems must be available for the rapid mobilization and distribution of medicines or vaccines according to the agent released. In the event that the agent is transmissible, additional capacity will be required for contact tracing and active surveillance. Some of the infectious agents of concern include bacteria and rickettsia (anthrax, brucellosis, melioidosis, plague, Q fever, tularemia, and typhus), fungi (coccidioidomycosis) and viruses (arboviruses, filoviruses and variola virus). International threat analysis xxxii considers that deliberate use of biological agents to cause harm is a real threat and that it can occur at any time; however, such risk analysis is not generally considered a public health function. According to national intelligence and defence services, there is evi- dence that national and international networks have engineered biological agents for use as weapons, in some instances with suggestions of attempts to increase pathogenicity and to develop delivery mechanisms for their deliberate use. Infection of humans may be a one-time occurrence, or may be repeated over a period of time after the initial occurrence. The agent used will determine whether there is a risk of person-to-person transmis- sion after the initial and subsequent attacks; information on this risk is covered in more detail under specific disease agents. Incubation period, period of communicability and susceptibility are agent-specific. Prevention of the deliberate use of biological agents presupposes accurate and up-to-date intelligence about terrorists and their activities. The agents may be manufactured using equipment necessary for the routine manufacture of drugs and vaccines, and the possibility of dual use of these facilities adds to the complexity of prevention. This has led some analysts to regard a strong public health infrastructure, with rapid and effective detection and response mechanisms for naturally occurring infectious diseases of outbreak potential, as the only reasonable means of responding to the threat of deliberately caused outbreaks of infectious disease. Adequate background information on the natural behaviour of infectious diseases will facilitate recognition of an unusual event and help determine whether suspicions of a deliberate use should be investigated. Preparedness for deliberate use also requires mechanisms that can be immediately called into action to enhance communication and collabora- tion among the public health authorities, the intelligence community, law enforcement agencies and national defence systems as need may arise. Preparedness should draw on existing plans for responding to large-scale natural disasters, such as earthquakes or industrial or transportation accidents, in which health care facilities are required to deal with a surge of casualties and emergency admissions. Most health workers will have little or no experience in managing illness arising from several of the potential infectious agents; training in clinical recognition and initial management may therefore be needed for first xxxiii responders. This training should include methods for infection control, safe handling of diagnostic specimens and body fluids, and decontamina- tion procedures. One of the most difficult issues for the public health system is to decide whether preparedness should include stockpiling of drugs, vaccines and equipment.
Public health action to prevent the adverse consequences of inappropriate dietary patterns and physical inactivity is now urgently needed cheap extra super cialis 100 mg with amex. To this end order generic extra super cialis online, the Consultation discussed how nutrient/food intake and physical activity goals could be used by policy-makers to increase the proportion of people who make healthier choices about food and undertake sufficient physical activity to maintain appropriate body weights and adequate health status discount extra super cialis 100mg without a prescription. This chapter discusses ways to catalyse the long-term changes that are needed to place people in a better position to make healthy choices about diet and physical activity. Such processes require long-term changes in thinking and action at the individual and societal levels; demand concerted action by national governments, international bodies, civil society and private entities and will need insights and energies contributed by multiple sectors of society. New scientific information will be essential to permit adjustment not only of the policy levers, but also of the strategic processes to introduce change. This constitutes an important focus for applied research that should yield useful evidence to guide effective interventions. The first is the range of possible policy principles that would help people achieve and maintain healthy dietary and activity patterns in a simple and rewarding manner. The second is the prerequisites for possible strategies to introduce these policies in different settings. These include the need for leadership, effective communication of problems and possible solutions, function- ing alliances, and ways of encouraging enabling environments to facilitate change. The third is the possible strategic actions to promote healthy diets and physical activity. Strategies should be comprehensive and address all major dietary and physical activity risks for chronic diseases together, alongside other risks --- such as tobacco use --- from a multisectoral perspective. Each country should select what will constitute the optimal mix of actions that are in accord with national capabilities, laws and economic realities. Governments have a central steering role in developing strategies, ensuring that actions are implemented and monitoring their impact over the long term. Ministries of health have a crucial convening role --- bringing together other ministries needed for effective policy design and implementation. Governments need to work together with the private sector, health professional bodies, consumer groups, academics, the research community and other nongovernmental bodies if sustained progress is to occur. This starts with maternal and child health, nutrition and care practices, and carries through to school and workplace environments, access to preventive health and primary care, as well as community- based care for the elderly and disabled people. Strategies should explicitly address equality and diminish disparities; they should focus on the needs of the poorest communities and population groups --- this requires a strong role for government. Furthermore, since women generally make decisions about household nutrition, strategies should be gender sensitive. There are limits to what individual countries can do alone to promote optimal diets and healthy living. Strategies need to draw substantially on existing international standards that provide a reference in international trade. Member States may wish to see additional standards that address, for example, the marketing of unhealthy food (particularly those high in energy, saturated fat, salt and free sugars, and poor in essential nutrients) to children across national boundaries. Countries may also wish to consider means of ensuring the accessibility of healthier choices (such as fruits and vegetables) to all socioeconomic groups. These include leadership, effective communication, functioning alliances and an enabling environment. Within nations, governments have the primary responsibility for providing this leadership. In some cases leadership may be initiated by civil society organizations prior to government action. It is unlikely that there will be just one correct path to improved health: each country will need to determine the optimal mix of policies that its particular circumstances best fit. Each country will need to select measures within the reality of its economic and social resources. More proactive leadership is needed, worldwide, to portray a holistic vision of food and nutritional issues as they affect overall health. Where this leadership has existed, it has been possible to make governments take notice and introduce the necessary changes. The question remains of how to develop and strengthen leadership capacity to reach a critical mass. Governments throughout the world have developed strategies to eradicate malnutrition, a term traditionally used synonymously with 136 undernutrition. However, the growing problems of nutritional imbal- ance, overweight and obesity, together with their implications for the development of diabetes, cardiovascular problems and other diet-related noncommunicable diseases, are now at least as pressing. This applies especially to developing countries undergoing the nutrition transition; such countries bear a double burden of both overnutrition, as well as undernutrition and infectious diseases. Unless there is political commit- ment to spur governments on to achieve results, strategies cannot succeed. Setting population goals for nutrient intake and physical activity is necessary but insufficient. Giving people the best chance to enjoy many years of healthy and active life requires action at the community, family and individual levels. The core role of health communication is to bridge the gap between technical experts, policy-makers and the general public. The proof of effective communications is its capacity to create awareness, improve knowledge and induce long-term changes in individual and social behaviours --- in this case consumption of healthy diets and incorporating physical activity for health. An effective health communication plan seeks to act on the opportunities at all stages of policy formulation and implementation, in order to positively influence public health. Sustained and well targeted communication will enable consumers to be better informed and make healthier choices. Informed consumers are better able to influence policy-makers; this was learned from work to limit the damage to health from tobacco use. Consumers can serve as advocates or may go on to lobby and influence their societies to bring about changes in supply and access to goods and services that support physical activity and nutritional goals. The cost to the world of the current and projected epidemic of chronic disease related to diet and physical inactivity dwarfs all other health costs. If society can be mobilized to recognize those costs, policy-makers will eventually start confronting the issue and themselves become advocates of change. Experience shows that politicians can also be influenced by the positions taken by the United Nations agencies, and the messages that they promote. Medical networks have also been found to be effective advocates of change in the presence of a government that is responsive to the health needs of society. Consumer nongovernmental organizations and a wide variety of civil society organizations will also be critical in raising consumer consciousness and supporting the climate 137 for constructive collaboration with the food industry and the private sector. Ideally, the effort should include a range of different parties whose actions influence people's options and choices about diet and physical activity. Alliances for action are likely to extend from communities to national and regional levels, involving formal focal points for nutrition within different public, private and voluntary bodies. The involvement of consumers associations is also important to facilitate health and nutrition education. Alliances with other members of the United Nations family are also important --- for example, with the United Nations Children's Fund on maternal --- child nutrition and life-course approachesto health. Private sectorindustry with interests in food production, packaging, logistics, retailing and marketing, and other private entities concerned with lifestyles, sports, tourism, recreation, and health and life insurance, have a key role to play.
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Ms X received compensation after being injured on a car ride at a theme park.
She was injured on the ride when, without warning, the car Ms X was sitting in came to a sharp halt. The car behind Ms X failed to stop and collided with the back of Ms X's car. The accident was reported to an attendant of the ride and the theme park.
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text:
#ifndef __CS_143_Flow__
#define __CS_143_Flow__
#include <string>
#include <set>
#include <memory>
#include <queue>
#include <memory>
#include "../EventHandling/Packet.h"
#include "../Tools/Log.h"

class CongestionAlg;
class Host;

// packet size is 100KB
static const int DATA_PKT_SIZE = 100000;

class Flow
{
public:
    // Host that owns the flow
    std::shared_ptr<Host> host;

    // ID of the flow
    std::string id;

    // source of the flow.  Should equal host->uuid
    std::string source;

    // Destination of the flow
    std::string destination;

    // Congestion algorithm associated with the flow.
    std::shared_ptr<CongestionAlg> a;

    // Total number of packets in the flow.
    int numPackets;

    // set of all packets that have been sent, but not acknowledged
    std::set<int> unAckedPackets;

    // How long the flow will wait before sending another packet.
    float waitTime;

    // window size
    int windowSize;

    // packet size
    int packetSize;

    // Time when the flow is generated.  Used to create a small set
    // of Events.
    float timestamp;

    // number of packets that have been acknowledged
    int numAcked;

    // Constructors
    Flow();
    Flow(std::string idval, std::string dest,
             std::shared_ptr<CongestionAlg> alg, int data_size, std::shared_ptr<Host> h,
             int winSize, float ts);

    // Called when there is a potentially unacknowledged event.
    // When we send a packet, we add an UnackEvent to the event heap.  Then,
    // when the event is handled, we check to see if it has been acknowledged.
    // If so, we have a no-op.  If not, resend.
    void handleUnackEvent(std::shared_ptr<Packet> unacked, float time);

    // Called when an ack is received.
    void handleAck(std::shared_ptr<Packet> p, float time);

    std::string toString();

    void initialize();
};

#endif /* defined(__CS_143_Flow__) */


text:
Intellectual Property and your R&D Career/Business
Intellectual property (IP) rights are important for supporting an innovation-driven economy and the growth of industry and commerce in Singapore. Singapore's IP regime has been ranked among the top five in the world by the World Economic Forum's Global Competitiveness Index since 2014. In line with Singapore's IP Hub Master Plan, it is desirable to develop skilled manpower to help businesses and R&D professionals harness IP with the aim of bringing ideas, products, services and brands to the global market. This two-day interactive workshop will provide participants with an introduction to IP with a focus on patents and more importantly, explore how such knowledge can be applied to their R&D careers/businesses.
Day 1 : Introduction to Intellectual Property, with a Focus on Patents
Importance of IP
Why IP is important on a National Level and within a Company
Basics of Patent Law
Anatomy of a Patent Specification
Patent Application Process (e.g. Singapore's Patents Regime, Paris Convention, PCT)
Patentability Requirements
How to Increase Chances of Obtaining a Patent
Introduction to Careers in IP
What are some of the careers in IP?
What skills sets are valuable for careers in IP?
Day 2 : Creating Value from Your Ideas
I have an Idea, Now What?
Importance of protecting your idea (e.g. by trade secrets, patents, designs, trademarks)
How to Capture and Assess Your Idea
How to carry out a prior art search, prepare a business plan (e.g. what the invention or creation is, why it would make a difference, how much would it cost, how it fits with the company's strategy)
Making Money from IP, with a Focus on Patents
Obtaining grants and attracting investors
Scientists, engineers and technical professionals involved in R&D work
Business owners considering IP protection for their R&D work
Diploma/Degree in Engineering or Science or relevant working experience with R&D activities
A Certificate of Participation will be issued to participants who
Attend 75% of the workshop; and
Welcome and Registration
Interactive session with hands-on activities
Quiz / Q&A
End of Day 1
Registration and Recap?
How to Capture and Assess Your Idea (cont'd)
Category Full Fee After SF Funding
Singapore Citizen (Below 40) / Singapore PR $1,712.00 $513.60
Date 29 Apr 2021 (Thu) to
30 Apr 2021 (Fri)
PHE3019A Process Safety Concepts
PHE3019B Fire and Explosion Prevention
Managing Workplace Relationships
CHE6011A Designing and Engineering for Safe Operations: Runaway Reactions and Dust Handling
13 Apr 2023 (Thu)
Writing in The Workplace
Sensory Evaluation - Pragmatic Applications in Workplace
Writing The Script for Microlearning Modules
PHE3019C Relief Systems: Types, Characteristics and Design Considerations
04 May 2023 (Thu)
CHE6011B Process Hazard Analysis
CHE6011C Layer of Protection Analysis (LOPA)
CHE6020A The Human Factor in Process Safety
CHE6020B Quantitative Risk Analysis
17 Aug 2023 (Thu)


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text:
is an adult visual novel/adventure game video game by Innocent Grey for Windows. It was released in Japan on July 4, 2008, and by MangaGamer (with the assistance of the TLWiki) for English-speaking markets on June 29, 2011.

Gameplay
Kara no Shōjos gameplay primarily revolves around reading dialogue with other characters and making choices that affect the outcome of the game.

At certain points in the game the player character, Reiji, is tasked with investigating crime scenes. During these investigation sequences, the player must examine these scenes to uncover evidence and depending on the evidence found, the course of the game can change. After collecting evidence, the player must put it together during inference sequences, in which Reiji must find the best answer from the clues obtained before. However, it is possible to fail an inference sequence by missing a given piece of evidence during a prior investigation; this in turn affects the game's ending.

The game also features a travel system, through which the player can traverse between different locations in Tokyo. The player can only use this a limited number of times per day, and only on certain days.

Plot
Set in a post-World War II Japan during 1956, Kara no Shōjo'''s story revolves around , a private investigator who is investigating a series of grotesque murders on the request of his former colleague/best friend,  of the Tokyo metropolitan police force. The murders are reminiscent of another string of serial murders that occurred six years ago prior to the game where Reiji lost his fiancée, which drives him with a strong desire to solve this case. Later at a park, Reiji also meets a high school girl from Ouba Girls Academy named , who asks him to find her real self. Reiji is initially unsure of what she means, but later finds out that Toko has an unusually complicated past that may have more to do with the current string of serial killings than Reiji initially expects. While working to solve the growing number of murder cases in Tokyo, Reiji takes some time out to get to know Toko and her friends as well as other students from her school while working behind-the-scenes to unravel the mysteries of her dark past.

Characters

The series main protagonist and a private detective that specializes in particularly brutal murder cases. Before the series events, Reiji worked in the police force but then he was forced to quit after the death of his beloved fiancée Yukiko; he lives with his younger sister Yukari-(a student at Ouba Academy) who he cares for dearly and wants to make sure that nothing bad happens to her. He doesn't spend too much of his time at home due to his work unless he's off duty; he enjoys reading history books during his free time, even when he's in his office. He also becomes a substitute teacher teaching history at the same school that his sister attends.

Reiji's younger sister and a high school student at the all-girls Ouba Academy. An old-fashioned, reliable type of girl, she's very close to her older brother and often takes care of him even when he tends to be helpless when it comes to doing household chores and will usually become concerned and worried when her brother has to go out and solve certain cases-(even if they're ones that could put his life at risk). Like Reiji she's very academic, but she has strong interests in entomology-(much to the dismay of some people including her brother) and has a huge collection of certain insects in her bedroom; on some occasions, her pet bugs end up appearing out of nowhere in certain parts of the house. She's a member of her school's art club.

A mysterious teenage girl who meets Reiji with a request that he help her find her "true self". Like Yukari, she attends Ouba Girls Academy along with being one of her classmates and also a member of the art club at her school; despite being one of the most popular students at school, she actually hides some secrets that no one else knows. She's shown to be a regular customer at Cafe Moon World, a restaurant/bar owned by Kyoko-(a widow whose husband died long before the series events).

 Kuchiki's best friend and classmate from school. Sharing the same name as each other-(but spelled differently), the two girls are often shown spending time and hanging out together. Due to her poor background and having to live in a broken home, she is shown to have a severe inferiority complex, because of this she hates her parents, herself, as well as other people around her, revealing that she's also victim of bullying and torment by some of her peers. Like most of the people from her school, she practically worships Kuchiki especially since she's been one of the few people that ignores her troubled background. Since her first encounter with Reiji during a school field trip, she holds a strong grudge against him fearing that he's trying to take her friend away.

Tsuzuriko is an aspiring writer and one of Yukari's classmates/best friend from school who serves as a comic relief in both the OVA and visual novel. She possesses a bright and hyperactive personality and has published multiple stories in many well known literary magazines while keeping her writing career a secret from her school. She's often referred to as "Tojiko" by Reiji claiming that her real name is hard to pronounce, much to her dismay.

 The president of the student council at Ouba Academy. A talented honor student, she comes from a wealthy, loving and influential family; her charisma makes her an idol of many of her classmates.

 Reiji's best friend and former colleague from the police. He and Reiji have known each other since they were students at the police academy where they both join the force and worked under the same supervisor. Even after his friend resigned from the police force, he still relies on Reiji's help in solving cases. He's also a regular customer at Cafe Moon World and has a crush on the owner, Kyouko.

The widowed owner of Cafe Moon World and a close acquaintance of Reiji and Uozumi (two of her regular customers). She is one of the few people who remembers Reiji's dark tragic past and she was also an old friend of his deceased fiancée. Since they've both lost someone important and special to them, they're able to connect on a more different level. Her cafe has a lot of regulars including Uozumi and Toko Kuchiki.

A waitress working at Cafe Moon World who used to help out at a brothel entitled Yukishiro, but after the establishment was shut down, Madam Ujaku took Hatsune under her wing and gave her the name Amemiya. She learned how to write from Shugo when they both lived at the Yukishiro brothel, so she gets mad whenever people say bad things about him.

Also known by his pen name, Shin Katsuragi (葛城 シン, Katsuragi Shin) or Katsuragi-sensei for short is one of the series main antagonists. He is shown to be famous well-known novelist and author of Shell of Sheol, one of his most popular published books. Unknown to most people, he is secretly a serial killer.

A school nurse at Ouba Girls Academy.

Touko's frail mother; she's often very gloomy and quiet type of person who often devotes all her time to her household duties.

Touko's calm and friendly uncle. He deeply cares a lot for his niece as she is the most precious person to him.

Touko's grandfather who seems to be a very grumpy fellow most of the time. He is also the chief physician of a local hospital.

A homeroom teacher at Ouba Academy. A highly unassuming person who doesn't stand out very much. He often advises Reiji that the school rules do not allow for much interaction between siblings. However he does appear to sympathize with Reiji as he struggles to deal with the seemingly emotionless students that lack any trace of individuality.

A half-Japanese friend of Reiji's who works as a tour guide at the art museum that Reiji and the students visit during a school field trip.

The vice principal of Ouba Girls Academy as well as the faculty advisor to the art club. He hires Reiji to search for the missing students at his school and pleads with him to conduct an investigation within school grounds in order to prevent any more casualties.

A psychiatrist at the hospital owned by the Kuchiki family.

Yui's best friend and classmate. She runs into Yukari and the rest of the art club members a lot. She became rather depressed after her friend's disappearance, and as a result doesn't talk to others as much as she used to.

A coroner who forbids anyone to address her as anything but "Natsume-san". Though she can be rather shady with her words and actions, her skill as a coroner is undisputed. Reiji met her during his time on the force, and still relies on her for important information. However, he tries to stay away from her as much as possible, as she tends to require "something" in exchange for information.

A private detective based in Ueno. Used to work with Reiji and Uozumi and still helps out his friends when needed. Married to Kazuna, a former client with whom he shares a lot of history. Since she's currently pregnant, Shugo focuses on less dangerous tasks like investigating cheating spouses and searching for people in order to worry her less.

A police officer who was part of the investigation team for the Ueno's serial killer and murder mystery. After the case got solved, he was transferred and promoted and has become a police officer of the National Police Agency in the Kara no Shoujo series.

An obstetrician at the Kuchiki Pathological Research Institute. A gentle person with a serious demeanor who likes taking care of people. Helps out during Reiji's investigation. Due to the small amount of doctors they have available, she often has to help with things other than her actual field of obstetrics.

A junior student of Yukari and Touko and best friends with Ayumu. She's revealed to be one of the missing students from the academy.

A famous well known stage actress. She went through a horrific past but then settled down and married Shugo. Seems to be comparatively more calm and mature after getting married. Due to her pregnancy, she is currently taking a break. Though she stays at home most of the time, she'll occasionally stop by Shugo's office from time to time to see to his needs.

Reiji's late fiancée who was murdered by Makoto Rokushiki long before the series events.

DevelopmentKara no Shōjo is developed by Innocent Grey. The original concept was by Miki Sugina.

An audition for the voice roles of five of the main female characters of Kara no Shojo was held in January 2008. 254 applicants attended the audition.

In 2011, a sequel for Kara no Shōjo was announced by Innocent Grey under the provisional title . The title was eventually changed to  and was released on February 8, 2013. The final installment  was released in Japan on 25 December 2020.

Release historyKara no Shōjo released its first demo on May 4, 2008 with the full version planned for release on July 4, 2008. Pre-orders of the game will come with a unique special packaging and an illustration book spanning 82 pages.

An English-language version of Kara no Shōjo was released on June 29, 2011, in a collaboration between MangaGamer and tlwiki. The game can be purchased and downloaded from the MangaGamer website. MangaGamer released Kara no Shoujo: The Second Episode in English on October 30, 2015.

Music
The music for the game is composed Manyo. The opening theme to Kara no Shōjo, named , was performed by Haruka Shimotsuki. The soundtrack for the game, named Azure, was released on the same day as the game on July 4, 2008.

Reception
During the month of June 2008, one month before Kara no Shōjo's release on July 4, 2008, Kara no Shōjo'' ranked sixth in national PC game pre-orders in Japan.

Adaptations
A 2 episode hentai OVA based on the game was made by MS pictures and released in 2010.

On January 3rd, 2023, an American, independent international media distributor Media Blasters has announced on their official Twitter page that an English dubbed production of the OVA is currently slated for a late winter 2023 release on Blu-Ray and DVD in the United States, featuring notable voice actors like Yara Naika.

References

External links
''Kara no Shōjo'''s official website
''Kara no Shōjo'''s official website

2008 video games
Adventure games
Christianity in fiction
Crime fiction
Detective video games
Eroge
Fiction set in 1956
Horror video games
MangaGamer games
Schools in fiction
Single-player video games
Video games developed in Japan
Video games set in Tokyo
Video games with alternate endings
Visual novels
Windows games
Windows-only games

redpajama_set_name: RedPajamaWikipedia


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Previewing The Perfect Pairing
Heather M, January 13, 2022
[Warning: General spoilers ahead.] Saturday night, Hallmark Channel rolls out an amnesia-themed romance starring Nazneen Contractor and Brennan Elliott, The Perfect Pairing follows Christina (Contractor), a jaded food critic who writes under the moniker "C.J.," as she heads to upstate New York for an assignment covering a wine festival. After…
Previewing North to Home
Heather M, January 7, 2022
[Warning: General spoilers ahead.] Sunday night on Hallmark Movies & Mysteries, director Ali Liebert helms North to Home, an ensemble family drama starring four of Hallmark's leading ladies–Lyndsy Fonseca, Kimberly Sustad, Erica Durance, and Barbara Niven, as three daughter and their mom who are forced to face old trauma when…
[Warning: General spoilers ahead.] Happy New Year, y'all! Saturday night, Hallmark Channel begins its The Wedding Veil trilogy of films inspired by Lori Wilde's Wedding Veil Wishes series and starring network powerhouses Lacey Chabert (who also executive produces), Alison Sweeney, and Autumn Reeser, who co-star in all three films, with…
Holiday Movies and Chill: The 2021 Home Stretch Edition
[Warning: General spoilers ahead.] There's been no shortage of falalalaing through the holiday romcoms this winter (all our coverage so far is here), so it's entirely possible that you missed a few. Here are some options for films currently streaming, repeating, and premiering this weekend. Hallmark Channel/Hallmark Movies & Mysteries…
Ashley Williams and Kimberly Williams-Paisley Talk Sister Swap
Heather M, December 9, 2021
[Warning: General spoilers ahead.] Hallmark Channel switched things up this year with a "hold my eggnog" response to its own sequels to bring us Sister Swap: A Hometown Holiday and Sister Swap: Christmas in the City, an intertwined pair of holiday movies anchored by sisters Kimberly Williams-Paisley and Ashley Williams…
Previewing Sister Swap: A Hometown Holiday and Christmas in the City
[Warning: General spoilers ahead. Separately, sisters Kimberly William-Paisley and Ashley Williams have become Hallmark staples, and this Sunday and next Sunday, they pool their talents for the first time in a pair of movies that flip the perspective on a threaded story. The first film, Sister Swap: A Hometown Holiday,…
Thanksgiving Holiday Weekend 2021 TV Mash-Up
Heather M, November 24, 2021
[Warning: General spoilers ahead.[ Long holiday weekends can be tricky, especially with a pandemic still brewing. Wherever you are, and however you choose to spend it, we wish you all the best. And if you find yourself looking for something to watch, and your interests are all over the place,…
Nikki DeLoach Previews Five More Minutes
[Warning: General spoilers ahead.] This Saturday on Hallmark Movies & Mysteries, Nikki DeLoach stars opposite David Haydn-Jones in Five More Minutes, a Christmas-themed take on the Scotty McCreery song. In the film, DeLoach is Clara, a teacher who comes home to have Christmas with her mom, Bonnie (Sherry Miller, who…
Previewing A Christmas Together With You
[Warning: General spoilers ahead.] Saturday on Hallmark Channel and W Network, Laura Vandervoort and The Blacklist's Harry Lennix headline A Christmas Together With You, which offers a different kind of Christmas story, and refreshingly, one that spends the bulk of its time reconciling a 50-year-old romance. Vandervoort is Megan, who…
Andrew Walker Talks My Christmas Family Tree
[Warning: General spoilers ahead.] Hallmark Channel mixes it up a little Saturday night with My Christmas Family Tree, an ensemble story about a found family that spins off a DNA match discovered right before Christmas. Aimee Teegarden plays Vanessa, a foster care worker for a non-profit, who's coaxed by her…


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Twin Research and Human Genetics (2)
International Soc for Twin Studies (2)
Plasmodium knowlesi: a superb in vivo nonhuman primate model of antigenic variation in malaria
M. R. GALINSKI, S. A. LAPP, M. S. PETERSON, F. AY, C. J. JOYNER, K. G. LE ROCH, L. L. FONSECA, E. O. VOIT, THE MAHPIC CONSORTIUM
Journal: Parasitology / Volume 145 / Issue 1 / January 2018
Published online by Cambridge University Press: 17 July 2017, pp. 85-100
Print publication: January 2018
Antigenic variation in malaria was discovered in Plasmodium knowlesi studies involving longitudinal infections of rhesus macaques (M. mulatta). The variant proteins, known as the P. knowlesi Schizont Infected Cell Agglutination (SICA) antigens and the P. falciparum Erythrocyte Membrane Protein 1 (PfEMP1) antigens, expressed by the SICAvar and var multigene families, respectively, have been studied for over 30 years. Expression of the SICA antigens in P. knowlesi requires a splenic component, and specific antibodies are necessary for variant antigen switch events in vivo. Outstanding questions revolve around the role of the spleen and the mechanisms by which the expression of these variant antigen families are regulated. Importantly, the longitudinal dynamics and molecular mechanisms that govern variant antigen expression can be studied with P. knowlesi infection of its mammalian and vector hosts. Synchronous infections can be initiated with established clones and studied at multi-omic levels, with the benefit of computational tools from systems biology that permit the integration of datasets and the design of explanatory, predictive mathematical models. Here we provide an historical account of this topic, while highlighting the potential for maximizing the use of P. knowlesi – macaque model systems and summarizing exciting new progress in this area of research.
Estimation of Prevalence of DSM-IV and Latent Class-Defined ADHD Subtypes in a Population-Based Sample of Child and Adolescent Twins
Rosalind J. Neuman, Nantawat Sitdhiraksa, Wendy Reich, Ted H.-C. Ji, Cynthia A. Joyner, Ling-Wei Sun, Richard D. Todd
Journal: Twin Research and Human Genetics / Volume 8 / Issue 4 / 01 August 2005
Print publication: 01 August 2005
The goal of this study is to determine the prevalence and age of onset of Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSMIV; American Psychiatric Association, 1994) and latent class-derived attention deficit/hyperactivity disorder (ADHD) subtypes in a population-based twin sample of boys and girls. Missouri birth records identified families with a twin pair 7 to 18 years of age. Telephone screening interviews for ADHD symptoms were completed for 5007 families. Diagnostic assessments were administered to 564 families with at least one twin meeting screening criteria, plus 183 control families. Prevalence and age of onset for both ADHD nosologies were calculated by sex and zygosity from parent report data. The prevalence of any DSM-IV ADHD was 6.2% overall, 7.4% in boys and 3.9% in girls. The inattentive subtype was most common in boys; the combined subtype was most common in girls. The mean age of onset of symptoms in children with any DSM-IV ADHD was 3.5 years, with no significant differences between boys and girls. Prevalences of latent class defined ADHD subtypes also varied by sex with the severe inattentive and combined classes more common in boys than girls. The age of onset of symptoms did not differ between boys and girls but were higher than in the DSM-IV subtypes. Findings in this twin sample showed that clinically significant ADHD, defined by either DSM-IV or latent class criterion, has an early age of onset and is more common in boys than girls. As clinical samples are most commonly composed of male combined subtypes, the inattentive subtype of both sexes in the general population is an under- treated segment of the general population.
Reliability and Stability of Mothers' Reports about their Pregnancies with Twins
Wendy Reich, Richard D. Todd, Cynthia A. Joyner, Rosalind J. Neuman, Andrew C. Heath
Journal: Twin Research and Human Genetics / Volume 6 / Issue 2 / 01 April 2003
Print publication: 01 April 2003
The objective of this study was to determine if mothers' retrospective reports about events in their pregnancies with twins are reliable and stable. Six hundred and twenty-four mothers completed psychiatric interviews about their twins. These interviews also contained questions about the mothers' pregnancies, the perinatal period, and the child's early development. The mothers reported first on one twin and then on the other with interviews spaced from 3 days to 2 weeks apart. Thus mothers reported on the same pregnancy twice. Of these mothers, 47 were re-interviewed 6 to 18 months later by raters blind to the results of the initial interview. The twin design allowed us to compare the short-term reliability of the 624 mothers' reports of the same pregnancy. The re-interview of the 47 mothers enabled us to compare the stability of reports over a longer time period. Agreement between the reports was measured with the kappa statistic. Kappas were good to excellent for the short-term reports of pregnancy for each twin for the 624 mothers. Kappas were equally high for the 47 mothers that were re-interviewed 6 to 18 months later. Mothers show good reliability and stability of reporting about events during pregnancy.
Structure/Reactivity Studies Of Nd2O3/MgO AND MgO/Nd2O3 Catalysts Used In Methane Coupling
A. Burrows, C. J. Kiely, R. W. Devenish, J. S. Hargreaves, G. J. Hutchings, R. W. Joyner, M. Y. Sinev
Published online by Cambridge University Press: 15 February 2011, 39
Using High Resolution Electron Microscopy, we have investigated the structure/function relationships of the Nd2O3/MgO and MgO/Nd2O3 catalyst systems which are active in the oxidative coupling of methane. In both cases catalytic performance was found to depend critically on the morphology of Nd2O3. We demonstrate that high selectivities are associated with a thin disordered film of neodymia on the MgO surface for the Nd2O3/MgO system whilst for the reverse catalyst, the dominant morphology is a highly disordered cubic form of Nd2O3.
Microstructural Studies of the WO3/TiO2 Monolayer Catalyst System Using High Resolution Electron Microscopy
A. Burrows, C. J. Kiely, R. W. Joyner, H. Knözinger, F. Lange
We have characterised the WO3T'iO2 (anatase) catalyst system using High Resolution Electron Microscopy. We will show that the overlayer preserves the surface roughness of titania and consists of 2D-hexagonal clusters that have a definite orientation relationship with the support. The contrast observed from these clusters is discussed in terms of existing structural models. A comparison between traditional chemical methods of preparation and simple mechanical mixing is made to assess the effectiveness of the latter to disperse WO3.
Morphological effects of arprinocid on developmental stages of Eimeria tenella and E. brunetti
S. J. Ball, R. M. Pittilo, C. C. Norton, L. P. Joyner
Journal: Parasitology / Volume 91 / Issue 1 / August 1985
Published online by Cambridge University Press: 06 April 2009, pp. 31-43
Medication of chicks with 70p.p.m. arprinoeid in the food, starting 2 days prior to inoculation with Eimeria tenella, resulted in decreased oocyst production and oocyst sporulation. The main morphological alteration seen during the development of the second-generation schizont was a reduction in the number of second-generation merozoites due to incomplete merogony, resulting in large masses of vacuolated residual cytoplasm. In places around the developing macrogamete the integrity of the parasitophorous vacuole was lost by either the host cell limiting membrane making contact with the parasite pellicle, or the disruption of one or both of these surfaces apparently brought about by the intervention of the host cell mitochondria. Thirty p.p.m. arprinocid reduced sporulation of the oocysts of E. brunetti and caused enlargement of the perinuclear space in the late merozoites and swelling of the endoplasmic reticulum around wall-forming bodies II.
Ultrastructural changes in the macrogamete and early oocyst of Eimeria maxima resulting from drug treatment
R. M. Pittilo, S. J. Ball, L. P. Joyner, C. C. Norton
Journal: Parasitology / Volume 83 / Issue 2 / October 1981
The ultrastructure of the macrogamete and developing oocyst of Eimeria maxima (Weybridge strain) was examined in the intestinal cells of chicks fed 3 different anticoccidial drugs. Amprolium at 125 p.p.m., arprinocid at 35 p.p.m. and dinitolmide at 250 p.p.m. caused considerable morphological abnormality and incomplete development of the wall-forming bodies of Type 2 (WFB II), which did not appear able to participate in oocyst wall formation. The wall-forming bodies of Type 1 (WFB I) were able in each case to participate in oocyst wall formation although amprolium and dinitolmide produced morphological abnormalities in them. In birds medicated with dinitolmide, the outer layer of the oocyst wall was formed initially at opposite poles of the macrogame tes rather than as a uniform layer. Other abnormalities resulting from drug treatment are reported and some evidence that intravacuolar tubules may be formed by the parasite pellicle is presented.
Scanning and transmission electron microscopy of Eimeria maxima microgametogenesis
S. J. Ball, R. M. Pittilo, L. P. Joyner, C. C. Norton
Journal: Parasitology / Volume 82 / Issue 1 / February 1981
The structure and development of microgametocytes of Eimeria maxima from chicks killed during the 6th day of infection were examined using transmission and scanning electron microscopy. Initially, nucleoli disappear and the surface of the microgametocyte invaginates. This is followed by a condensation of the chromatin which then lies at the periphery of the nuclei. Concurrent with this, the flagella are formed and they project into the parasitophorous vacuole and internal invaginations. Eventually, the nuclei become more dense and are seen to protrude from the periphery of the gametocyte. The surface view of mature microgametocytes consists of a large number of closely packed flagella.
Preliminary Studies in the Use of Herbicides for the Control of Weeds in Sansevieria
Edward O. Gangstad, Charles C. Seale, J. Frank Joyner
Journal: Weeds / Volume 2 / Issue 2 / April 1953
A high quality cordage fiber can be obtained from certain species of sansevieria (3, 5, 8, 10). Laboratory and small scale manufacturing tests indicate that this fiber is a suitable substitute for abaca, a fiber which is critical for defense purposes. (1,9). Weed competition has been a major problem in the culture of sansevieria for fiber because the plant has a slow rate of growth and a long period of time is required to develop a stand.


Global executive search firm Stanton Chase announced today that J. James O'Malley, a veteran search consultant, has been appointed Managing Director in the Chicago office. As Managing Director, O'Malley will serve as a senior member of the Professional Services and Financial Services practice groups for Stanton Chase.
"I am thrilled to welcome Jim to our team in Chicago, he brings 30 years of executive leadership experience and a track record of exceeding his clients' expectations," said Bernie Layton, Managing Director and Global Practice Leader.
O'Malley's new role centers around senior level searches for the Professional Services and Financial services practice groups in Chicago with a focus on ensuring leadership talent aligns with changing business needs across the groups.
Most recently, Jim was a Partner and Executive Search Practice Leader at TalentRISE, a recruitment solutions firm in Chicago. Prior to his search career O'Malley worked for several professional service firms including; Arthur Andersen, Deloitte, Huron Consulting and Lante.
Jim is a graduate of DePaul University and serves on the Executive Committee and Board of Directors for HFS Chicago Scholars. His past affiliations include the boards of Sheila Greco & Associates, Staffing Management Association of Chicago (STAR) and Mount Assisi Academy. He is also an active member of the Society of Human Resources Professionals, Human Resource Management Association of Chicago and the Metropolitan Club of Chicago.


Below you'll find a recursive and an iterative version of the Factorial algorithm in Lisp/Scheme, based on the book Structure and Interpretation of Computer Programs (SICP).
Notice that in this version the procedure (i.e., the function) is still recursive, as it's defined in terms of itself. However, since it's a tail recursion, the Lisp interpreter/compiler will generate an iterative process, where the variables will be kept through out all iterations.
This entry was posted in Lisp / Scheme on February 3, 2014 by Daniel Scocco.