text:
Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels
The LifeLines Cohort Study, CHARGE Lipids Working Group
Background So far, more than 170 loci have been associated with circulating lipid levels through genomewide association studies (GWAS). These associations are largely driven by common variants, their function is often not known, and many are likely to be markers for the causal variants. In this study we aimed to identify more new rare and low-frequency functional variants associated with circulating lipid levels. Methods We used the 1000 Genomes Project as a reference panel for the imputations of GWAS data from ~60 000 individuals in the discovery stage and ~90 000 samples in the replication stage. Results Our study resulted in the identification of five new associations with circulating lipid levels at four loci. All four loci are within genes that can be linked biologically to lipid metabolism. One of the variants, rs116843064, is a damaging missense variant within the ANGPTL4 gene. Conclusions This study illustrates that GWAS with high-scale imputation may still help us unravel the biological mechanism behind circulating lipid levels.
Journal of Medical Genetics
https://doi.org/10.1136/jmedgenet-2015-103439
The AGES Study has been funded by NIH contracts N01-AG-1-2100 and HHSN271201200022C, the NIA Intramural Research Program, Hjartavernd (the Icelandic Heart Association), and the Althingi (the Icelandic Parliament). The Airwave Study is funded by the Home Office (grant number 780-TETRA) with additional support from the National Institute for Health Research (NIHR) Imperial College Healthcare NHS Trust (ICHNT) and Imperial College Biomedical Research Centre (BRC). PE is an NIHR Senior Investigator and is supported by the ICHNT and Imperial College BRC, the MRC-PHE Centre for Environment and Health and the NIHR Health Protection Research Unit on Health Impact of Environmental Hazards. The ARIC Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute (NHLBI) contracts (HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C), R01HL087641, R01HL59367 and R01HL086694; National Human Genome Research Institute contract U01HG004402; and National Institutes of Health contract HHSN268200625226C. Cardiovascular Health Study: This CHS research was supported by NHLBI contracts HHSN268201200036C, HHSN268200800007C, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086; and NHLBI grants U01HL080295, R01HL087652, R01HL105756, R01HL103612, and R01HL120393 with additional contribution from the National Institute of Neurological Disorders and Stroke (NINDS). Additional support was provided through R01AG023629 from the National Institute on Aging (NIA). A full list of principal CHS investigators and institutions can be found at CHS-NHLBI.org. The provision of genotyping data was supported in part by the National Center for Advancing Translational Sciences, CTSI grant UL1TR000124, and the National Institute of Diabetes and Digestive and Kidney Disease Diabetes Research Center (DRC) grant DK063491 to the Southern California Diabetes Endocrinology Research Center. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. CROATIA-Korcula, CROATIA-Split and CROATIA-Vis (CR-Korcula, CR-Split, CR-Vis) were funded by the Medical Research Council UK, The Croatian Ministry of Science, Education and Sports (grant 216-1080315-0302), the European Union framework program 6 EUROSPAN project (contract no. LSHG-CT-2006-018947) and the Croatian Science Foundation (grant 8875). The ERF study as a part of EUROSPAN (European Special Populations Research Network) was supported by European Commission FP6 STRP grant number 018947 (LSHG-CT-2006-01947) and also received funding from the European Community's Seventh Framework Programme (FP7/2007-2013)/grant agreement HEALTH-F4-2007-201413 by the European Commission under the programme "Quality of Life and Management of the Living Resources" of 5th Framework Programme (no. QLG2-CT-2002-01254). The ERF study was further supported by ENGAGE consortium and CMSB. High-throughput analysis of the ERF data was supported by joint grant from Netherlands Organisation for Scientific Research and the Russian Foundation for Basic Research (NWO-RFBR 047.017.043). Exome sequencing in ERF was supported by the ZonMw grant (project 91111025). The Family Heart Study was supported by the by grants R01-HL-087700, R01-HL-088215 and R01-HL-117078 from the National Heart, Lung, and Blood Institute. Generation Scotland received core funding from the Chief Scientist Office of the Scottish Government Health Directorate CZD/16/6 and the Scottish Funding Council HR03006. Genotyping of the GS:SFHS samples was carried out by the Genetics Core Laboratory at the Wellcome Trust Clinical Research Facility, Edinburgh, Scotland and was funded by the UK's Medical Research Council. The LifeLines Cohort Study, and generation and management of GWAS genotype data for the LifeLines Cohort Study is supported by the Netherlands Organization of Scientific Research NWO (grant 175.010.2007.006), the Economic Structure Enhancing Fund (FES) of the Dutch government, the Ministry of Economic Affairs, the Ministry of Education, Culture and Science, the Ministry for Health, Welfare and Sports, the Northern Netherlands Collaboration of Provinces (SNN), the Province of Groningen, University Medical Center Groningen, the University of Groningen, Dutch Kidney Foundation and Dutch Diabetes Research Foundation. The Leiden Longevity Study (LLS) has received funding from the European Union's Seventh Framework Programme (FP7/2007-2011) under grant agreement no 259679. This study was supported by a grant from the Innovation-Oriented Research Program on Genomics (SenterNovem IGE05007), the Centre for Medical Systems Biology, and the Netherlands Consortium for Healthy Ageing (grant 050-060-810), all in the framework of the Netherlands Genomics Initiative, Netherlands Organization for Scientific Research (NWO), UnileverColworth and by BBMRI-NL, a Research Infrastructure financed by the Dutch government (NWO 184.021.007). The LOLIPOP study is supported by the National Institute for Health Research (NIHR) Comprehensive Biomedical Research Centre Imperial College Healthcare NHS Trust, the British Heart Foundation (SP/04/002), the Medical Research Council (G0601966,G0700931), the Wellcome Trust (084723/Z/08/Z) the NIHR (RP-PG-0407-10371),European Union FP7 (EpiMigrant, 279143) and Action on Hearing Loss (G51). The work was carried out in part at the NIHR/Wellcome Trust Imperial Clinical Research Facility. The NEO study is supported by the participating Departments, the Division and the Board of Directors of the Leiden University Medical Center, and by the Leiden University, Research Profile Area 'Vascular and Regenerative Medicine'. Dennis Mook-Kanamori is supported by Dutch Science Organization (ZonMW-VENI Grant 916.14.023). ORCADES was supported by the Chief Scientist Office of the Scottish Government, the Royal Society, the MRC Human Genetics Unit, Arthritis Research UK and the European Union framework program 6 EUROSPAN project (contract no. LSHG-CT-2006-018947). DNA extractions were performed at the Wellcome Trust Clinical Research Facility in Edinburgh. The PROSPER study was supported by an investigator initiated grant obtained from Bristol-Myers Squibb. JWJ is an Established Clinical Investigator of the Netherlands Heart Foundation (grant 2001 D 032). Support for genotyping was provided by the seventh framework program of the European commission (grant 223004) and by the Netherlands Genomics Initiative (Netherlands Consortium for Healthy Aging grant 050-060-810). The generation and management of GWAS genotype data for the Rotterdam Study is supported by the Netherlands Organisation of Scientific Research NWO Investments (nr. 175.010.2005.011, 911-03-012). This study is funded by the Research Institute for Diseases in the Elderly (014-93-015; RIDE2), the Netherlands Genomics Initiative (NGI)/Netherlands Organisation for Scientific Research (NWO) project nr. 050-060-810. The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University, Rotterdam, Netherlands Organization for the Health Research and Development (ZonMw), the Research Institute for Diseases in the Elderly (RIDE), the Ministry of Education, Culture and Science, the Ministry for Health, Welfare and Sports, the European Commission (DG XII), and the Municipality of Rotterdam. Participating centres of TRAILS include the University Medical Center and University of Groningen, the Erasmus University Medical Center Rotterdam, the University of Utrecht, the Radboud Medical Center Nijmegen, and the Parnassia Bavo group, all in the Netherlands. TRAILS has been financially supported by various grants from the Netherlands Organization for Scientific Research NWO (Medical Research Council program grant GB-MW 940-38-011; ZonMW Brainpower grant 100-001-004; ZonMw Risk Behavior and Dependence grants 60-60600-97-118; ZonMw Culture and Health grant 261-98-710; Social Sciences Council medium-sized investment grants GB-MaGW 480-01-006 and GB-MaGW 480-07-001; Social Sciences Council project grants GB-MaGW 452-04-314 and GB-MaGW 452-06-004; NWO large-sized investment grant 175.010.2003.005; NWO Longitudinal Survey and Panel Funding 481-08-013 and 481-11-001), the Dutch Ministry of Justice (WODC), the European Science Foundation (EuroSTRESS project FP-006), Biobanking and Biomolecular Resources Research Infrastructure BBMRI-NL (CP 32), and the participating universities.
10.1136/jmedgenet-2015-103439
Dive into the research topics of 'Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels'. Together they form a unique fingerprint.
Association Biochemistry, Genetics and Molecular Biology 100%
Lipid Level Biochemistry, Genetics and Molecular Biology 80%
Lipid Medicine and Dentistry 80%
Loci Agricultural and Biological Sciences 60%
Association Study Computer Science 60%
Nested Gene Biochemistry, Genetics and Molecular Biology 40%
ANGPTL4 Biochemistry, Genetics and Molecular Biology 40%
Gene Medicine and Dentistry 40%
The LifeLines Cohort Study, & CHARGE Lipids Working Group (2016). Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels. Journal of Medical Genetics, 53(7), 441-449. https://doi.org/10.1136/jmedgenet-2015-103439
The LifeLines Cohort Study ; CHARGE Lipids Working Group. / Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels. In: Journal of Medical Genetics. 2016 ; Vol. 53, No. 7. pp. 441-449.
@article{fe2a46c1df9442adbc300a40f97aab70,
title = "Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels",
abstract = "Background So far, more than 170 loci have been associated with circulating lipid levels through genomewide association studies (GWAS). These associations are largely driven by common variants, their function is often not known, and many are likely to be markers for the causal variants. In this study we aimed to identify more new rare and low-frequency functional variants associated with circulating lipid levels. Methods We used the 1000 Genomes Project as a reference panel for the imputations of GWAS data from ~60 000 individuals in the discovery stage and ~90 000 samples in the replication stage. Results Our study resulted in the identification of five new associations with circulating lipid levels at four loci. All four loci are within genes that can be linked biologically to lipid metabolism. One of the variants, rs116843064, is a damaging missense variant within the ANGPTL4 gene. Conclusions This study illustrates that GWAS with high-scale imputation may still help us unravel the biological mechanism behind circulating lipid levels.",
author = "{The LifeLines Cohort Study} and {CHARGE Lipids Working Group} and {van Leeuwen}, {Elisabeth M.} and Aniko Sabo and Bis, {Joshua C.} and Huffman, {Jennifer E.} and Ani Manichaikul and Smith, {Albert V.} and Feitosa, {Mary F.} and Serkalem Demissie and Joshi, {Peter K.} and Qing Duan and Jonathan Marten and {van Klinken}, {Jan B.} and Ida Surakka and Nolte, {Ilja M.} and Weihua Zhang and Hamdi Mbarek and Ruifang Li-Gao and Stella Trompet and Niek Verweij and Evangelos Evangelou and Lyytik{\"a}inen, {Leo Pekka} and Tayo, {Bamidele O.} and Joris Deelen and {van der Most}, {Peter J.} and {van der Laan}, {Sander W.} and Arking, {Dan E.} and Alanna Morrison and Abbas Dehghan and Franco, {Oscar H.} and Albert Hofman and Fernando Rivadeneira and Sijbrands, {Eric J.} and Uitterlinden, {Andre G.} and Mychaleckyj, {Josyf C.} and Archie Campbell and Hocking, {Lynne J.} and Sandosh Padmanabhan and Brody, {Jennifer A.} and Rice, {Kenneth M.} and White, {Charles C.} and Tamara Harris and Aaron Isaacs and Harry Campbell and Lange, {Leslie A.} and Igor Rudan and Ivana Kolcic and Pau Navarro and Tatijana Zemunik and Veikko Salomaa and Vilmundur Gudnason",
note = "Funding Information: The AGES Study has been funded by NIH contracts N01-AG-1-2100 and HHSN271201200022C, the NIA Intramural Research Program, Hjartavernd (the Icelandic Heart Association), and the Althingi (the Icelandic Parliament). The Airwave Study is funded by the Home Office (grant number 780-TETRA) with additional support from the National Institute for Health Research (NIHR) Imperial College Healthcare NHS Trust (ICHNT) and Imperial College Biomedical Research Centre (BRC). PE is an NIHR Senior Investigator and is supported by the ICHNT and Imperial College BRC, the MRC-PHE Centre for Environment and Health and the NIHR Health Protection Research Unit on Health Impact of Environmental Hazards. The ARIC Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute (NHLBI) contracts (HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C), R01HL087641, R01HL59367 and R01HL086694; National Human Genome Research Institute contract U01HG004402; and National Institutes of Health contract HHSN268200625226C. Cardiovascular Health Study: This CHS research was supported by NHLBI contracts HHSN268201200036C, HHSN268200800007C, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086; and NHLBI grants U01HL080295, R01HL087652, R01HL105756, R01HL103612, and R01HL120393 with additional contribution from the National Institute of Neurological Disorders and Stroke (NINDS). Additional support was provided through R01AG023629 from the National Institute on Aging (NIA). A full list of principal CHS investigators and institutions can be found at CHS-NHLBI.org. The provision of genotyping data was supported in part by the National Center for Advancing Translational Sciences, CTSI grant UL1TR000124, and the National Institute of Diabetes and Digestive and Kidney Disease Diabetes Research Center (DRC) grant DK063491 to the Southern California Diabetes Endocrinology Research Center. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. CROATIA-Korcula, CROATIA-Split and CROATIA-Vis (CR-Korcula, CR-Split, CR-Vis) were funded by the Medical Research Council UK, The Croatian Ministry of Science, Education and Sports (grant 216-1080315-0302), the European Union framework program 6 EUROSPAN project (contract no. LSHG-CT-2006-018947) and the Croatian Science Foundation (grant 8875). The ERF study as a part of EUROSPAN (European Special Populations Research Network) was supported by European Commission FP6 STRP grant number 018947 (LSHG-CT-2006-01947) and also received funding from the European Community's Seventh Framework Programme (FP7/2007-2013)/grant agreement HEALTH-F4-2007-201413 by the European Commission under the programme {"}Quality of Life and Management of the Living Resources{"} of 5th Framework Programme (no. QLG2-CT-2002-01254). The ERF study was further supported by ENGAGE consortium and CMSB. High-throughput analysis of the ERF data was supported by joint grant from Netherlands Organisation for Scientific Research and the Russian Foundation for Basic Research (NWO-RFBR 047.017.043). Exome sequencing in ERF was supported by the ZonMw grant (project 91111025). The Family Heart Study was supported by the by grants R01-HL-087700, R01-HL-088215 and R01-HL-117078 from the National Heart, Lung, and Blood Institute. Generation Scotland received core funding from the Chief Scientist Office of the Scottish Government Health Directorate CZD/16/6 and the Scottish Funding Council HR03006. Genotyping of the GS:SFHS samples was carried out by the Genetics Core Laboratory at the Wellcome Trust Clinical Research Facility, Edinburgh, Scotland and was funded by the UK's Medical Research Council. The LifeLines Cohort Study, and generation and management of GWAS genotype data for the LifeLines Cohort Study is supported by the Netherlands Organization of Scientific Research NWO (grant 175.010.2007.006), the Economic Structure Enhancing Fund (FES) of the Dutch government, the Ministry of Economic Affairs, the Ministry of Education, Culture and Science, the Ministry for Health, Welfare and Sports, the Northern Netherlands Collaboration of Provinces (SNN), the Province of Groningen, University Medical Center Groningen, the University of Groningen, Dutch Kidney Foundation and Dutch Diabetes Research Foundation. The Leiden Longevity Study (LLS) has received funding from the European Union's Seventh Framework Programme (FP7/2007-2011) under grant agreement no 259679. This study was supported by a grant from the Innovation-Oriented Research Program on Genomics (SenterNovem IGE05007), the Centre for Medical Systems Biology, and the Netherlands Consortium for Healthy Ageing (grant 050-060-810), all in the framework of the Netherlands Genomics Initiative, Netherlands Organization for Scientific Research (NWO), UnileverColworth and by BBMRI-NL, a Research Infrastructure financed by the Dutch government (NWO 184.021.007). The LOLIPOP study is supported by the National Institute for Health Research (NIHR) Comprehensive Biomedical Research Centre Imperial College Healthcare NHS Trust, the British Heart Foundation (SP/04/002), the Medical Research Council (G0601966,G0700931), the Wellcome Trust (084723/Z/08/Z) the NIHR (RP-PG-0407-10371),European Union FP7 (EpiMigrant, 279143) and Action on Hearing Loss (G51). The work was carried out in part at the NIHR/Wellcome Trust Imperial Clinical Research Facility. The NEO study is supported by the participating Departments, the Division and the Board of Directors of the Leiden University Medical Center, and by the Leiden University, Research Profile Area 'Vascular and Regenerative Medicine'. Dennis Mook-Kanamori is supported by Dutch Science Organization (ZonMW-VENI Grant 916.14.023). ORCADES was supported by the Chief Scientist Office of the Scottish Government, the Royal Society, the MRC Human Genetics Unit, Arthritis Research UK and the European Union framework program 6 EUROSPAN project (contract no. LSHG-CT-2006-018947). DNA extractions were performed at the Wellcome Trust Clinical Research Facility in Edinburgh. The PROSPER study was supported by an investigator initiated grant obtained from Bristol-Myers Squibb. JWJ is an Established Clinical Investigator of the Netherlands Heart Foundation (grant 2001 D 032). Support for genotyping was provided by the seventh framework program of the European commission (grant 223004) and by the Netherlands Genomics Initiative (Netherlands Consortium for Healthy Aging grant 050-060-810). The generation and management of GWAS genotype data for the Rotterdam Study is supported by the Netherlands Organisation of Scientific Research NWO Investments (nr. 175.010.2005.011, 911-03-012). This study is funded by the Research Institute for Diseases in the Elderly (014-93-015; RIDE2), the Netherlands Genomics Initiative (NGI)/Netherlands Organisation for Scientific Research (NWO) project nr. 050-060-810. The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University, Rotterdam, Netherlands Organization for the Health Research and Development (ZonMw), the Research Institute for Diseases in the Elderly (RIDE), the Ministry of Education, Culture and Science, the Ministry for Health, Welfare and Sports, the European Commission (DG XII), and the Municipality of Rotterdam. Participating centres of TRAILS include the University Medical Center and University of Groningen, the Erasmus University Medical Center Rotterdam, the University of Utrecht, the Radboud Medical Center Nijmegen, and the Parnassia Bavo group, all in the Netherlands. TRAILS has been financially supported by various grants from the Netherlands Organization for Scientific Research NWO (Medical Research Council program grant GB-MW 940-38-011; ZonMW Brainpower grant 100-001-004; ZonMw Risk Behavior and Dependence grants 60-60600-97-118; ZonMw Culture and Health grant 261-98-710; Social Sciences Council medium-sized investment grants GB-MaGW 480-01-006 and GB-MaGW 480-07-001; Social Sciences Council project grants GB-MaGW 452-04-314 and GB-MaGW 452-06-004; NWO large-sized investment grant 175.010.2003.005; NWO Longitudinal Survey and Panel Funding 481-08-013 and 481-11-001), the Dutch Ministry of Justice (WODC), the European Science Foundation (EuroSTRESS project FP-006), Biobanking and Biomolecular Resources Research Infrastructure BBMRI-NL (CP 32), and the participating universities.",
doi = "10.1136/jmedgenet-2015-103439",
journal = "Journal of Medical Genetics",
The LifeLines Cohort Study & CHARGE Lipids Working Group 2016, 'Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels', Journal of Medical Genetics, vol. 53, no. 7, pp. 441-449. https://doi.org/10.1136/jmedgenet-2015-103439
Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels. / The LifeLines Cohort Study; CHARGE Lipids Working Group.
In: Journal of Medical Genetics, Vol. 53, No. 7, 01.07.2016, p. 441-449.
T1 - Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels
AU - The LifeLines Cohort Study
AU - CHARGE Lipids Working Group
AU - van Leeuwen, Elisabeth M.
AU - Sabo, Aniko
AU - Bis, Joshua C.
AU - Huffman, Jennifer E.
AU - Manichaikul, Ani
AU - Smith, Albert V.
AU - Feitosa, Mary F.
AU - Demissie, Serkalem
AU - Joshi, Peter K.
AU - Duan, Qing
AU - Marten, Jonathan
AU - van Klinken, Jan B.
AU - Surakka, Ida
AU - Nolte, Ilja M.
AU - Zhang, Weihua
AU - Mbarek, Hamdi
AU - Li-Gao, Ruifang
AU - Trompet, Stella
AU - Verweij, Niek
AU - Evangelou, Evangelos
AU - Lyytikäinen, Leo Pekka
AU - Tayo, Bamidele O.
AU - Deelen, Joris
AU - van der Most, Peter J.
AU - van der Laan, Sander W.
AU - Arking, Dan E.
AU - Morrison, Alanna
AU - Dehghan, Abbas
AU - Franco, Oscar H.
AU - Hofman, Albert
AU - Rivadeneira, Fernando
AU - Sijbrands, Eric J.
AU - Uitterlinden, Andre G.
AU - Mychaleckyj, Josyf C.
AU - Campbell, Archie
AU - Hocking, Lynne J.
AU - Padmanabhan, Sandosh
AU - Brody, Jennifer A.
AU - Rice, Kenneth M.
AU - White, Charles C.
AU - Harris, Tamara
AU - Isaacs, Aaron
AU - Campbell, Harry
AU - Lange, Leslie A.
AU - Rudan, Igor
AU - Kolcic, Ivana
AU - Navarro, Pau
AU - Zemunik, Tatijana
AU - Salomaa, Veikko
AU - Gudnason, Vilmundur
N1 - Funding Information: The AGES Study has been funded by NIH contracts N01-AG-1-2100 and HHSN271201200022C, the NIA Intramural Research Program, Hjartavernd (the Icelandic Heart Association), and the Althingi (the Icelandic Parliament). The Airwave Study is funded by the Home Office (grant number 780-TETRA) with additional support from the National Institute for Health Research (NIHR) Imperial College Healthcare NHS Trust (ICHNT) and Imperial College Biomedical Research Centre (BRC). PE is an NIHR Senior Investigator and is supported by the ICHNT and Imperial College BRC, the MRC-PHE Centre for Environment and Health and the NIHR Health Protection Research Unit on Health Impact of Environmental Hazards. The ARIC Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute (NHLBI) contracts (HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C), R01HL087641, R01HL59367 and R01HL086694; National Human Genome Research Institute contract U01HG004402; and National Institutes of Health contract HHSN268200625226C. Cardiovascular Health Study: This CHS research was supported by NHLBI contracts HHSN268201200036C, HHSN268200800007C, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086; and NHLBI grants U01HL080295, R01HL087652, R01HL105756, R01HL103612, and R01HL120393 with additional contribution from the National Institute of Neurological Disorders and Stroke (NINDS). Additional support was provided through R01AG023629 from the National Institute on Aging (NIA). A full list of principal CHS investigators and institutions can be found at CHS-NHLBI.org. The provision of genotyping data was supported in part by the National Center for Advancing Translational Sciences, CTSI grant UL1TR000124, and the National Institute of Diabetes and Digestive and Kidney Disease Diabetes Research Center (DRC) grant DK063491 to the Southern California Diabetes Endocrinology Research Center. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. CROATIA-Korcula, CROATIA-Split and CROATIA-Vis (CR-Korcula, CR-Split, CR-Vis) were funded by the Medical Research Council UK, The Croatian Ministry of Science, Education and Sports (grant 216-1080315-0302), the European Union framework program 6 EUROSPAN project (contract no. LSHG-CT-2006-018947) and the Croatian Science Foundation (grant 8875). The ERF study as a part of EUROSPAN (European Special Populations Research Network) was supported by European Commission FP6 STRP grant number 018947 (LSHG-CT-2006-01947) and also received funding from the European Community's Seventh Framework Programme (FP7/2007-2013)/grant agreement HEALTH-F4-2007-201413 by the European Commission under the programme "Quality of Life and Management of the Living Resources" of 5th Framework Programme (no. QLG2-CT-2002-01254). The ERF study was further supported by ENGAGE consortium and CMSB. High-throughput analysis of the ERF data was supported by joint grant from Netherlands Organisation for Scientific Research and the Russian Foundation for Basic Research (NWO-RFBR 047.017.043). Exome sequencing in ERF was supported by the ZonMw grant (project 91111025). The Family Heart Study was supported by the by grants R01-HL-087700, R01-HL-088215 and R01-HL-117078 from the National Heart, Lung, and Blood Institute. Generation Scotland received core funding from the Chief Scientist Office of the Scottish Government Health Directorate CZD/16/6 and the Scottish Funding Council HR03006. Genotyping of the GS:SFHS samples was carried out by the Genetics Core Laboratory at the Wellcome Trust Clinical Research Facility, Edinburgh, Scotland and was funded by the UK's Medical Research Council. The LifeLines Cohort Study, and generation and management of GWAS genotype data for the LifeLines Cohort Study is supported by the Netherlands Organization of Scientific Research NWO (grant 175.010.2007.006), the Economic Structure Enhancing Fund (FES) of the Dutch government, the Ministry of Economic Affairs, the Ministry of Education, Culture and Science, the Ministry for Health, Welfare and Sports, the Northern Netherlands Collaboration of Provinces (SNN), the Province of Groningen, University Medical Center Groningen, the University of Groningen, Dutch Kidney Foundation and Dutch Diabetes Research Foundation. The Leiden Longevity Study (LLS) has received funding from the European Union's Seventh Framework Programme (FP7/2007-2011) under grant agreement no 259679. This study was supported by a grant from the Innovation-Oriented Research Program on Genomics (SenterNovem IGE05007), the Centre for Medical Systems Biology, and the Netherlands Consortium for Healthy Ageing (grant 050-060-810), all in the framework of the Netherlands Genomics Initiative, Netherlands Organization for Scientific Research (NWO), UnileverColworth and by BBMRI-NL, a Research Infrastructure financed by the Dutch government (NWO 184.021.007). The LOLIPOP study is supported by the National Institute for Health Research (NIHR) Comprehensive Biomedical Research Centre Imperial College Healthcare NHS Trust, the British Heart Foundation (SP/04/002), the Medical Research Council (G0601966,G0700931), the Wellcome Trust (084723/Z/08/Z) the NIHR (RP-PG-0407-10371),European Union FP7 (EpiMigrant, 279143) and Action on Hearing Loss (G51). The work was carried out in part at the NIHR/Wellcome Trust Imperial Clinical Research Facility. The NEO study is supported by the participating Departments, the Division and the Board of Directors of the Leiden University Medical Center, and by the Leiden University, Research Profile Area 'Vascular and Regenerative Medicine'. Dennis Mook-Kanamori is supported by Dutch Science Organization (ZonMW-VENI Grant 916.14.023). ORCADES was supported by the Chief Scientist Office of the Scottish Government, the Royal Society, the MRC Human Genetics Unit, Arthritis Research UK and the European Union framework program 6 EUROSPAN project (contract no. LSHG-CT-2006-018947). DNA extractions were performed at the Wellcome Trust Clinical Research Facility in Edinburgh. The PROSPER study was supported by an investigator initiated grant obtained from Bristol-Myers Squibb. JWJ is an Established Clinical Investigator of the Netherlands Heart Foundation (grant 2001 D 032). Support for genotyping was provided by the seventh framework program of the European commission (grant 223004) and by the Netherlands Genomics Initiative (Netherlands Consortium for Healthy Aging grant 050-060-810). The generation and management of GWAS genotype data for the Rotterdam Study is supported by the Netherlands Organisation of Scientific Research NWO Investments (nr. 175.010.2005.011, 911-03-012). This study is funded by the Research Institute for Diseases in the Elderly (014-93-015; RIDE2), the Netherlands Genomics Initiative (NGI)/Netherlands Organisation for Scientific Research (NWO) project nr. 050-060-810. The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University, Rotterdam, Netherlands Organization for the Health Research and Development (ZonMw), the Research Institute for Diseases in the Elderly (RIDE), the Ministry of Education, Culture and Science, the Ministry for Health, Welfare and Sports, the European Commission (DG XII), and the Municipality of Rotterdam. Participating centres of TRAILS include the University Medical Center and University of Groningen, the Erasmus University Medical Center Rotterdam, the University of Utrecht, the Radboud Medical Center Nijmegen, and the Parnassia Bavo group, all in the Netherlands. TRAILS has been financially supported by various grants from the Netherlands Organization for Scientific Research NWO (Medical Research Council program grant GB-MW 940-38-011; ZonMW Brainpower grant 100-001-004; ZonMw Risk Behavior and Dependence grants 60-60600-97-118; ZonMw Culture and Health grant 261-98-710; Social Sciences Council medium-sized investment grants GB-MaGW 480-01-006 and GB-MaGW 480-07-001; Social Sciences Council project grants GB-MaGW 452-04-314 and GB-MaGW 452-06-004; NWO large-sized investment grant 175.010.2003.005; NWO Longitudinal Survey and Panel Funding 481-08-013 and 481-11-001), the Dutch Ministry of Justice (WODC), the European Science Foundation (EuroSTRESS project FP-006), Biobanking and Biomolecular Resources Research Infrastructure BBMRI-NL (CP 32), and the participating universities.
N2 - Background So far, more than 170 loci have been associated with circulating lipid levels through genomewide association studies (GWAS). These associations are largely driven by common variants, their function is often not known, and many are likely to be markers for the causal variants. In this study we aimed to identify more new rare and low-frequency functional variants associated with circulating lipid levels. Methods We used the 1000 Genomes Project as a reference panel for the imputations of GWAS data from ~60 000 individuals in the discovery stage and ~90 000 samples in the replication stage. Results Our study resulted in the identification of five new associations with circulating lipid levels at four loci. All four loci are within genes that can be linked biologically to lipid metabolism. One of the variants, rs116843064, is a damaging missense variant within the ANGPTL4 gene. Conclusions This study illustrates that GWAS with high-scale imputation may still help us unravel the biological mechanism behind circulating lipid levels.
AB - Background So far, more than 170 loci have been associated with circulating lipid levels through genomewide association studies (GWAS). These associations are largely driven by common variants, their function is often not known, and many are likely to be markers for the causal variants. In this study we aimed to identify more new rare and low-frequency functional variants associated with circulating lipid levels. Methods We used the 1000 Genomes Project as a reference panel for the imputations of GWAS data from ~60 000 individuals in the discovery stage and ~90 000 samples in the replication stage. Results Our study resulted in the identification of five new associations with circulating lipid levels at four loci. All four loci are within genes that can be linked biologically to lipid metabolism. One of the variants, rs116843064, is a damaging missense variant within the ANGPTL4 gene. Conclusions This study illustrates that GWAS with high-scale imputation may still help us unravel the biological mechanism behind circulating lipid levels.
U2 - 10.1136/jmedgenet-2015-103439
DO - 10.1136/jmedgenet-2015-103439
JO - Journal of Medical Genetics
JF - Journal of Medical Genetics
The LifeLines Cohort Study, CHARGE Lipids Working Group. Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels. Journal of Medical Genetics. 2016 Jul 1;53(7):441-449. doi: 10.1136/jmedgenet-2015-103439


The EADS Innovation Works are the corporate research centres of EADS, with sites in Germany, France, Spain, Singapore and Russia and provide world-class capabilities in aeronautics, defence and space research topics. Consistent with the EADS research & technology strategy and covering the skills and technology fields that are of critical importance to the EADS group of companies, the EADS Innovation Works are organized in five trans-national Technical Capability Centres: Composites Technologies - Metallic Technologies & Surface Engineering - Structures Engineering, Production & Mechatronics - Sensors, Electronics and Systems Integration - Simulation, Information Technologies & Systems Engineering. The EADS Innovation Works are an operational and strategic entity for the creation of added value by technology innovation.


text:
Sago Report Struck By Lightning
I have been lucky enough never to have a tragedy in my immediate family. I've never lost a loved one in an accident.
But one thing I've learned after working many years in workplace safety is that families need some kind of closure when their loved is killed in a workplace accident, and they rarely get it, particularly from OSHA or other agencies that are tasked with investigating the incident and issuing citations. All too often I hear stories from parents or spouses that they never really got the whole story on what exactly happened to their husband or daughter, and what the real causes were. Too often they're just given a list of OSHA violations, a short summary of the cause of death, and whispered allegations that the victims themselves were at fault for being careless or negligent.
So it was completely understandable how upset the families of the miners killed in the Sago disaster last year were following the release of the state of West Virginia's report on the tragedy by Ronald Wooten, director of the state Office of Miners' Health, Safety and Training.
On Monday, Wooten came under heavy criticism from families of the Sago victims after a private meeting that was billed as a briefing for families on the state's new report on the disaster.
Families were upset when Wooten simply provided them with copies of the thick report, told them lightning caused the disaster, and asked for questions.
When families asked questions, they were told the answers were in the report and that they should read it.
Families had expected a more detailed — and understandable — briefing, similar to one that was provided a month ago to families of the two miners killed in the Aracoma Mine fire.
Also, families became angrier when they learned that Wooten's agency had posted the report — or at least one version of it — on its Web site hours before the family meeting. Families had thought they would learn the report's contents first, but by the time their meeting ended, the report was all over the news.
The report was then withdrawn, initially because it was to be re-written, but later Wooten said that they were only preparing a better briefing for the families.
Wooten came under significant criticism when he was appointed due to his controversial career in the coal industry as former vice president of safety for CONSOL Energy Inc. from 1983 until 1998, a lawyer and lobbyist for CONSOL before that, and a lawyer for the American Mining Congress, an industry group.
A couple of other things. Even if lightning was involved, it was only one cause of the disaster. To be more precise, it may have been the ignition source of the explosion. But the explosion itself only killed one of the miners, and then only because the seals behind the closed off part of the mine didn't hold. The others died from asphyxiation for a number of reasons: the respirators either malfunctioned or the miners were not trained to use them properly (or both), it took too long for the rescue team to enter the mine, rescuers had no way to locate the miners, and the miners had no way to communicate with the surface.
In other words, simply telling the families that "lightning caused the disaster" period, end and go read the report yourselves was at best insensitive, and at worst ignorent, incompetent and not a statement that someone heading up the state's mine safety office should ever have made.
To make matters worse, the Associated Press reported that Wooten
told relatives of the Sago Mine disaster victims that he "wouldn't want to be in there" if another electrical storm rolled over an active underground coal mine with a worked-out, recently sealed area, the brother of one victim said today.
Yet the state has taken no action to change its rules and regulations.
John Groves, whose brother Jerry was among 12 men who died in or after the Jan. 2 blast, said the comment came in a private meeting earlier this week as he and others questioned Ron Wooten, director of the state Office of Miners' Health, Safety and Training.
The families asked Wooten a series of questions about how the state would respond now that its investigation report has blamed lightning for causing the Sago explosion. They then pressed the point on active mines with newly sealed areas, asking what he would do.
"I wouldn't want to be in there," Wooten allegedly replied.
Several other people who were in the room at the time told The Associated Press the same account of that conversation.
Wooten's comment prompted a response from the United Mineworkers:
"I think there are 14,000 coal miners in West Virginia that wouldn't want to be in there, either," said United Mine Workers spokesman Phil Smith, when told of Wooten's remark.
Since learning the state would join Sago Mine owner International Coal Group Inc. in blaming lightning, the UMW has called for new regulations that require miners to be evacuated when an electrical storm is approaching.
Wooten's simplistic explanation was even a bit too much for MSHA head Richard Stickler. MSHA is preparing its own report on the Sago disaster:
Stickler indicated a partial answer on the cause from his team would not be acceptable.
"If it was lightning, how did it get in the mine? If you don't know that, you don't know how to keep it out, do you?" he said. "There's questions there we need the answers to."
Stickler also seemed to learn a lesson from Wooten's presentation:
Stickler said he will be present when his agency's report is given to the Sago families, and that they will have the chance to question the investigators.
"We will give them copies of report, but not necessarily expect them to sit there and read the report and know what's in it," he said.
I'm sure the families would appreciate that.
Labels: Coal Mining, Richard Stickler, Sago
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redpajama_set_name: RedPajamaCommonCrawl


text:
November 4, 2019 November 10, 2020 Tim Worthington
Do Not Viddy This, My Brothers!
This was originally commissioned for A Leading Film Website as part of a feature they were running on whether the thrill of queueing outside a cinema had been consigned to history by Netflix or something. It didn't make it into the final piece, and judging from what did, I imagine they were looking for a little less contentious and a little more about a big crowd of people singing 'Star Wars' to the tune of the Star Wars theme while waiting to see Star Wars. Maybe it was a little off-topic in fairness, but even so, it's hard to avoid the suspicion that even now, A Clockwork Orange has still not shaken off the heavy chill of notoriety that surrounded it for far too long. Almost as if they felt it was a malenky lomtick sinister.
I later loaned this reworked version to a website I was a fan of to draw a bit more attention to it, and then reused it in Can't Help Thinking About Me, in a longer version with much more background on my longstanding moviegoing relationship with the much-missed 051 Cinema. In fact there's a lot more in Can't Help Thinking About Me about old-skool cinema visits and various hi-jinks, mishaps, and very occasionally about watching the actual film itself. You can get Can't Help Thinking About Me in paperback here or from the Kindle Store here.
This is the story of how I didn't see a movie.
A Clockwork Orange, Stanley Kubrick's controversial (not least with the author himself) 1971 big-screen version of Anthony Burgess' acclaimed novel, had caused a vivid furore on its release, and by the end of the decade had been withdrawn from UK distribution at the director's request. There have been wild stories of threats and protests outside the Kubrick family home from 'anti-violence' protesters, though it's also worth remembering that the film was used as a political football by moralising blowhards like pretty much no other before or since; including, to Burgess' great frustration, one James Wilson Vincent Savile. What an excellent arbiter of socially responsible behaviour he turned out to be. Anyway, whatever the reason, withdraw it Kubrick certainly did, and with home entertainment still really only in its infancy, this meant that – for UK audiences at least – A Clockwork Orange pretty much disappeared off the face of the planet.
As you can imagine, this made A Clockwork Orange a very intriguing prospect indeed to any self-respecting young student of the weird and lurid corners of cinema history. Surreally stylised and futuristic photos in books about 'Sci-Fi Films' were a nagging reminder of its tantalising unavailability. It stood almost alone as a movie that had been a huge hit one minute then basically erased from history the next, while older cousins and more verbose rock journalists hinted at a secret knowledge of it that you weren't allowed to share. Even the row about its content and suitability seemed more exciting than it maybe should have warranted. The fact that even if it had been available, I would have been too young to actually see A Clockwork Orange was neither here nor there – I was as obsessed with it as others were with A Nightmare On Elm Street or Predator. I read the book, I listened to the fantastic soundtrack album, I even cut out and kept a Guardian article about the RSC's stage adaptation starring Phil Daniels as Alex. There was just one small but significant flaw with this fanaticism – I hadn't actually seen the film itself.
There were rumours, of course, that it was widely available on 'pirate', but it always seemed to command the sort of sums of money that you didn't particularly want to be handing over to shifty teenagers on street corners, especially when you'd already seen the woeful quality of some of their more easily affordable wares. And so it was that, long after I'd seen Twisted Nerve, Peeping Tom, The Magic Christian, Supervixens, Cannibal Apocalyse, Vampyros Lesbos, The Trip, Monte Carlo Or Bust!, Psychomania, 200 Motels, Two-Lane Blacktop, Every Home Should Have One, The Rise And Rise Of Michael Rimmer and many other tantalisingly elusive doodles in the margin of cinema history, A Clockwork Orange remained my one big Halliwell-troubling box to tick. Yet despite the occasional frowning in a newspaper article accompanied by a badly-cropped version of that photo of Alex at the wheel of a car, it was still nowhere nearer becoming available.
Then, one day, a rumour began to circulate amongst members of a local Cinema Club that they were going to stage a secret – and not even remotely Kubrick-approved – screening of an under-the-counter print of the film to mark their tenth anniversary. Whether they ever actually intended to or not nobody really knows, as some ingrate prat promptly leaked the story to an illiterate muck-raking grief-porn-peddling chip-on-regional-shoulder local newspaper, who went predictably condemnatory crazy with the story – no prizes for guessing which photo they used to accompany it – prompting the cinema to issue a strenuous denial that they'd ever even considered it. Was this all a clever double-bluff, though? Was it worth running the risk of missing out on an actual chance to see it, and subsequently having to administer a self-kicking worthy of Alex and his Droogs? There was only one way to find out – to turn up on the supposed date and time and see if they were actually showing it away from prying smudgy-newsprint eyes.
As it turned out, I wasn't the only one who'd had that idea. A sizeable crowd had gathered outside the suspiciously darkened venue, made up primarily of studenty types holding cineaste-friendly impromptu discussions, nervy-looking lone gentlemen with an apparent disdain for washing their raincoats, and a small army of people in boiler suits and bowler hats. Oh, and a reporter, who was pleasingly blanked by everyone she attempted to speak to. As the night set in, the weather got colder, and it became increasingly obvious to anyone with a shred of sense that there was nobody actually inside the building, the Droogs seized their moment. A flurry of brolly-rapping on the determinedly shut doors and shouts to the effect of "but the slovo did viddy that the film would be on all horrorshow" did nothing to change the situation, so they started to indulge in in-character jostling of fellow would-be patrons instead. Once they began to loudly decry the arrival of 'the millicents', it really was time to give up and go home.
So, that's how effective banning films really is in terms of preventing copycat violence. Of course, there was also the time someone threw a full carton of Kia Ora at my head, but that's another story. And I actually saw the film that time too.
You can find an expanded version of this feature, with much more about cinema foyer tomfoolery and other decidedly non-cineaste-appropriate antics, in Can't Help Thinking About Me, available in paperback here or from the Kindle Store here.
You can find more tales of the 051 Cinema and its eclectic repertoire of movies – in particular True Crime oddity The Young Poisoner's Handbook – in the edition of Looks Unfamiliar with me as the guest, which you can listen to here.
Phil Daniels
Previous Looks Unfamiliar #53: Richard Littler – This Is All That Is Left… Of A Wall
Next The Zeitgeist Tapes: Vote For Froglet


At LaRocca's there's only one thing we love more than wine-it's cheese!
While it's difficult to imagine not enjoying a sip of wine with a hunk of your favorite cheese, certain combinations will particularly titillate your tongue and make your soul sing.
Join us for a whirlwind class and tasting of 5 wines and 5 cheeses with Arethusa Farms and our Resident Sommelier, Ross Edward Marks.
Learn which cheese types best match your favorite wines and get insider tips on how to find the right match on your own. Join us for a pairing session to explicate the essential fundamentals of wine and cheese harmony.
Best Part. The class is only $10 and you get to take some cheese home with you.
Hope you can join us. We've designed our educational events to offer you a myriad of ways to get your knowledge on.


Embark on a fascinating journey into the culture, heritage, knowledge, skills and contemporary life of the San/Bushman people. Guided tours are offered and can be taken on foot or by bicycle. Indigenous to the area, the San have a wealth of knowledge of the region and are intrinsically tied to it. A great outing for young and old.


Congratulations, you're going to college full time. How are you going to pay for it?
Unless you have the means to pay for college out of pocket, all college educations begin with a hard search for any and all available financial aid streams. This will generally begin with filling out the Free Application for Federal Student Aid (FAFSA). It's at this point that the concepts of free and college typically part ways.
The FAFSA form provides a deep examination of your family's income, assets and what dollar amount you'll be expected to contribute to the college education, based on combined household income. Even if you plan to attend a private college, you'll still be required to fill out the FAFSA form. Private schools often use the federal methodology to determine whether and how much need-based financial aid you may qualify for.
There are two broad types of financial aid: need-based and merit-based. Both may have limitations to qualifications depending on how many hours the student takes during the semester that's being paid for. If you're fortunate enough to be able to attend school as a full time student, then congratulations; most schools allow full-time students to qualify for 100 percent of financial aid. This doesn't mean that you'll automatically receive financial aid of any kind as a full-time student. It only means that you're eligible to receive that percentage.
So what are the ways that you might be able to cobble together 100 percent of your college tuition costs? In this article we'll look at the offers that American students have available to help them get through college without resorting to a life of crime. On the next page we'll look at the most desirable way, grants and scholarships.


text:
package com.hazelcast.spring.cache;

import com.hazelcast.core.HazelcastInstance;
import com.hazelcast.map.MapLoaderLifecycleSupport;
import com.hazelcast.map.MapStore;

import java.util.Collection;
import java.util.Map;
import java.util.Properties;
import java.util.Set;

public class CacheMapLoader implements MapStore, MapLoaderLifecycleSupport {

    private String type;

    @Override
    public void init(HazelcastInstance hazelcastInstance, Properties properties, String mapName) {
        type = mapName;
    }

    @Override
    public void destroy() {
    }

    @Override
    public Object load(Object key) {
        return type + ":" + key;
    }

    @Override
    public Map loadAll(Collection keys) {
        return null;
    }

    @Override
    public Set loadAllKeys() {
        return null;
    }

    @Override
    public void store(Object key, Object value) {
    }

    @Override
    public void storeAll(Map map) {
    }

    @Override
    public void delete(Object key) {
    }

    @Override
    public void deleteAll(Collection keys) {
    }
}

redpajama_set_name: RedPajamaGithub


If you are a current volunteer, you can view your schedule using our online scheduling system. Enter the username and password that you received via email to get started. If you have trouble or run into questions, contact Cathy 862-3636.
Volunteers are always needed at His Hands Free Clinic. In fact, everything we do relies on the support and efforts of our volunteers! Common volunteer positions are described below. Check them out and see if we might be a good fit for your skills and passions. We also encourage interested professionals in related medical fields (EMT, Physical Therapist, Occupational Therapist, etc.) to get involved.
For insurance purposes, our licensed volunteers must have personal liability insurance. If you don't carry your own, you can get the appropriate coverage through the Volunteer Health Care Provider Program through the Iowa Department of Public Health. Contact us for more details.
Qualifications: Unrestricted Iowa license, professional malpractice insurance or insurance through the VHCPP program, experience preferred.
Frequency: Minimum once a month for two hours.
When: During clinics (Tuesdays/Thursdays 5 – 7 p.m., or Wednesdays and Thursdays 10 a.m. to 2 p.m.) If these times don't work, we can work around your schedule. Please call for more details.
Note for specialist volunteers: Our patients need specialists too!
Frequency: Minimum of once a month for two hours.
Qualifications: Licensed pharmacists, Pharmacy Technicians, experience preferred.
Qualifications: Unrestricted Iowa license, professional malpractice insurance or get insurance through the VHCPP program, experience preferred.
Qualifications: Pleasant attitude, organized, dependable, phone experience a plus, experience preferred.
Volunteers to greet patients, schedule appointments and various other administrative tasks.
Qualifications: Pleasant attitude, organized, dependable, experience preferred.
When: Monday through Friday between 9 a.m. and 4 p.m. or Tuesday and Thursday evenings from 5-7 p.m.
Volunteers to provide spiritual care by praying with patients.
Frequency: Minimum of once a month.
When: During medical, chiropractic or dental clinics.
Are you looking for a project for your small group of friends? We have various group projects including cleaning, painting and providing snacks for our volunteers. Contact us and we will put your group to work!
We work to show the love of God to our friends and neighbors by meeting their medical, prescription, chiropractic and dental needs. We can only do this with your support.
There's a lot going on at His Hands. God has been showing us new needs in the community and challenging us to find ways to meet them. Your prayers are needed more than ever.


text:
Q: How to redraw a custom QQuickItem I have created a custom QML Element by extending QQuickItem and overriding the updatePaintNode() function. I am drawing two lines on my application which will expand or shrink in size based on the block size that gets added on the left side of the application. This block can be added in small and big modes and can be removed by selecting the buttons on the top bar.
This is my code:
line.cpp
#include <QSGGeometry>
#include <QSGGeometryNode>
#include <qsgnode.h>
#include <qsgflatcolormaterial.h>
#include "line.h"

Lines::Lines(QQuickItem *parent) : QQuickItem(parent) {
    setFlag(QQuickItem::ItemHasContents, true);
}

Lines::~Lines() {}

QSGNode *Lines::updatePaintNode(QSGNode *oldNode, UpdatePaintNodeData *) {
    QSGGeometryNode *node = NULL;
    QSGGeometry *geometry = NULL;
    QSGGeometry::Point2D *vertices;
    QSGFlatColorMaterial *material;
    int points = 0;
    int lineHeight = 0;
    int ys = 0;
    int xs;
    int xe;

    points = width();

    if (!oldNode)
    {
        node = new QSGGeometryNode;
        geometry = new QSGGeometry(QSGGeometry::defaultAttributes_Point2D(), points);
        geometry->setLineWidth(1);
        geometry->setDrawingMode(GL_LINES);
        node->setGeometry(geometry);
        node->setFlag(QSGNode::OwnsGeometry);
        material = new QSGFlatColorMaterial;
        material->setColor("white");
        node->setMaterial(material);
        node->setFlag(QSGNode::OwnsMaterial);
    }
    else
    {
        node = static_cast<QSGGeometryNode *>(oldNode);
        geometry = node->geometry();
        geometry->allocate(points);
    }

    vertices = geometry->vertexDataAsPoint2D();
    lineHeight = (height() / 4);

    xs = 0;
    xe = width() - xs;

    for(int i = 0; i < 2; i++)
    {
        ys = ( i * lineHeight);
        vertices[(2*i)].set(xs, ys);
        vertices[(2*i)+1].set(xs + xe, ys);
    }

    node->markDirty(QSGNode::DirtyForceUpdate);
    return node;
}

line.h
#include <QQuickItem>

class Lines : public QQuickItem
{
    Q_OBJECT
public:
    Lines(QQuickItem *parent = 0);
    ~Lines();

    QSGNode *updatePaintNode(QSGNode *, UpdatePaintNodeData *);
};

main.cpp
#include <QGuiApplication>
#include <QQmlApplicationEngine>
#include "line.h"

int main(int argc, char *argv[])
{
    QGuiApplication app(argc, argv);

    QQmlApplicationEngine engine;
    qmlRegisterType<Lines>("lines", 1, 0, "Lines");

    engine.load(QUrl(QStringLiteral("qrc:/main.qml")));

    return app.exec();
}

main.qml
import QtQuick 2.4
import QtQuick.Window 2.2
import QtQuick.Controls 1.0
import lines 1.0

Window {
    id: canvas

    height: 500
    width: 500
    color: "black"
    visible: true

    Rectangle {
        id: topBar

        height: 40
        Row {
            spacing: 10
            Button {
                text: "Small"
                onClicked: {
                    rect.visible = true
                    rect.width = 50
                }
            }
            Button {
                text: "Big"
                onClicked: {
                    rect.visible = true
                    rect.width = 100
                }
            }
            Button {
                text: "None"
                onClicked: {
                    rect.visible = false
                    rect.width = 0
                }
            }
        }
    }

    Rectangle {
        id: rect

        anchors {
            left: parent.left
            top: topBar.bottom
            bottom: parent.bottom
        }

        color: "grey"
        visible: false
    }

    Rectangle {
        id: rect2

        anchors {
            left: rect.right
            right: parent.right
            top: topBar.bottom
            bottom: parent.bottom
        }

        color: "black"

        Lines {
            id: lines

            x: 0
            y: 100

            width: parent.width
            height: 225
        }
    }
}

I am seeing that when I select the left Grey block (using the buttons) the Lines were not redrawn properly and I see some glitches. The attached picture below shows my output with glitches.

I have tried calling node->markDirty(QSGNode::DirtyForceUpdate) but it is of no use.
How can I fix this issue. Please help. Thanks in advance.

redpajama_set_name: RedPajamaStackExchange


Last April, the Law School announced the opening of the Guarini Institute for Global Legal Studies with a celebration at 22 Washington Square North, the institute's new home. Supported by a $20 million gift from Frank J. Guarini '50, LLM '55, the Guarini Institute extends the Law School's international reach by building on existing programs and introducing new ones. Benedict Kingsbury, vice dean for global programs and Murry and Ida Becker Professor of Law, who serves as faculty director of the institute, sat down with editorial director Emily Barker to talk about the ingredients for "Global 2.0," the intersection of transnational law and technology, and why it's more important than ever for the Law School to engage internationally.
Why do you think this is the time to start an initiative like the Guarini Institute?
From the standpoint of people living in the United States, the nature of global order since 1945 has been substantially aligned with US visions of the world, with a particular kind of liberal capitalism. Especially once the Cold War ended, the sense that American or North Atlantic values could be made global became very strong.
Quite rapidly, probably from the early 2000s onward, that understanding began to dissipate. Over time, there emerged somewhat different models. In particular, the spectacular increase in power and vitality of China has begun to project a different view of the state and society. And alongside that is the importance of India, the gradual flourishing of some parts of African societies, and the energization of Southeast Asia and parts of Latin America, and different engagements with Russia.
We are seeing increasing authoritarianism in some parts of the world, and a multiplicity of models of governance. We see now globalization as it has been—the continuous flows of capital and the connectedness and interdependence of markets and strong communications—and at the same time there is now deglobalization, including the rise of populist leaders and the exit of countries from treaties that in the past they would have been part of, such as Britain going outside the European Union.
The nature of the international orders in which this generation of students will be working and living is much more complicated. Some old platitudes are now exposed for being that. Some real challenges are clear to everybody, and some are incipient, and they're going to become very difficult.
We believe that this is exactly the right time to be engaging with the world, and the Guarini Institute is well placed to do it. We'll be trying to think about the way that the world's going and work through big ideas, recommendations for the world that's being made and that we all ourselves are part of making.
Will the Guarini Institute focus on any particular parts of the world?
We don't have the aim of being a regionally focused enterprise. NYU Law does have a lot of historic connections across the North Atlantic. The importance of China in the world is reflected in our programs and thinking—as is, increasingly, the importance of India, Indonesia, Japan, and other East Asian countries.
We also would very much like to deepen our real connections with Latin America. We have terrific groups of LLM students from many of those countries. Brazil is the second largest LLM cohort after China. We could be more systematic about our connections and joint projects in Latin America, including Mexico, which is one area where we hope we can move forward quite quickly.
We are already working in Guarini with some Mexican scholars doing that. We hope over time to be able to do more work with African universities, African scholars, African students, and NYU Law students working in Africa. We believe we can do a lot to really build there.
Can you tell us about the Guarini Institute's mission, and how it fits into NYU Law's existing international programs?
What we are trying to support through Guarini is what you can call Global 2.0 for NYU Law. Since 1995 the Hauser Program has worked to bring outstanding people to New York and to make a rich, intellectually vibrant community here that brings the law and practice of other countries and international, transnational issues into the now-daily legal activities of all sorts in the school.
So the next step, 2.0, has been to think more about how NYU Law can be out in the world.
The key existing program that the Guarini Institute is supporting is the Law Abroad Program, which was a very important innovation in legal education, letting JD students spend a semester in our own NYU Law programs in Buenos Aires, in Paris, or in Shanghai. We had more than 50 students this spring across those places.
As well, we're going to do a more comprehensive job of international moot courts. We intend to appoint a coordinator for all of our international moot court negotiation competitions. The teams so far have been very self-organized—our aim is to systematize it.
We'll also be supporting some regular international lectures— for example, the Jean Monnet program, which features world leaders coming to give an annual lecture. And there is also a set of conferences with international dimensions that we will support.
We all felt internally that with such a magnificent gift and initial support, it was a chance for the school to take another step. Our new step is to focus on the digital world, the digitalization of society, and the transborder elements of that shift. This program is the Guarini Global Tech Law Program.
One element will be student externships—New York being a great advantage locationally for that. Our aim there is to provide students with experiential engagement—in particular, with United Nations agencies and other international agencies who are trying to develop, often with limited resources or special expertise, new uses of digital technology in their own work. For example, blockchain and some sort of scanning ID system might be used to make sure that, when funds are sent to support a refugee family of displaced people, the person who is supposed to receive the money is receiving the money. Our idea is that a law student could add something to these projects. Quite often there is not much lawyering in the whole process, and sometimes that can prove to be a problem.
A second element will be providing a combination of training and cutting-edge thinking and research opportunities for students, addressing global tech law issues. So we have a Guarini Colloquium, which is taught by Joseph Straus Professor of Law Joseph Weiler and me and Adjunct Professor of Law Thomas Streinz, on the international law of global digital corporations. We look at how these companies operate in the world, how they deal with different governments and different regulatory environments.
A third is a more specialized course, Global Tech Law, which will be launched in Spring 2019. It sits alongside the outstanding expertise our NYU faculty have in intellectual property, innovation, competition law and privacy, large algorithms, algorithm accountability. But we are adding a global dimension, so that students who have an international orientation—which is really strong at NYU—can learn about the tech world and have influence on important choices being made there.
Our assumption is that the experience of being a transnationally capable lawyer is really changing. Whether they are in a law firm or in an NGO or in different kinds of government—and certainly in international organizations and in the business world— increasingly lawyers are directly working with tech products. Perhaps they are trying to produce them or choose among them or to help with some development or perhaps to challenge some problematic conduct in the tech and data space. We believe that it's a little bit like financial literacy—that familiarity with the digital world is another part of the equipment of a good global lawyer.
The Guarini Institute's launch on April 4 featured a lively conversation between Justice Sonia Sotomayor of the US Supreme Court and Albie Sachs, a former justice of the Constitutional Court of South Africa.
Sotomayor began by asking Sachs whether he would advise future justices to take an originalist approach to applying South Africa's constitution. "In 200 years…will your successors be well served in trying to think how their founding fathers would have solved the problem?" she said.
Sachs noted that since he helped write South Africa's constitution, he is literally an "originalist." But even the constitution's drafters can't reconstruct its original meaning now, he said: "There were so many people, and you had a draft, and it was amended, it was changed. I can recall a couple of phrases I can put my little flag on. 'No detention without trial'…'an open and democratic society'…the word 'open,' I insisted on that. For the rest, I was involved in the Bill of Rights, in fundamental rights, in the structures of government, everything, but I don't think anyone can say, 'This is what we actually meant,' because there wasn't an intention in that sense… .
Guarini previously funded the Frank J. Guarini Center for Environmental, Energy, and Land Use Law, the Frank J. Guarini Leaders in Government Service Institute, and the Guarini Government Lecture. "With his latest gift, Frank is helping ensure that the Law School maintains its preeminent position in international legal scholarship and education," Dean Trevor Morrison said.
After growing up in Jersey City, New Jersey, Guarini served as a naval navigator in the Pacific during World War II, receiving the Navy Commendation Medal and three Battle Stars. In addition to his NYU Law degree, Guarini pursued advanced studies at The Hague Academy of International Law. Following a career in law and real estate investment in Jersey City, Guarini served two terms in the New Jersey State Senate and seven terms in the US House of Representatives.
In public office, Guarini took a strong interest in international matters. In 1979 he met with Chinese leader Deng Xiaoping as part of the first US government mission to discuss opening China's doors to trade. He served as a delegate to the North Atlantic Treaty Organization and as US representative to the United Nations General Assembly. Italian President Giorgio Napolitano awarded him Italy's highest honor, the Knight of the Grand Cross of the Order of Merit of the Italian Republic.


text:
Written on 30 November 2009 . Posted in Climate
ClimateGate Hearings to Start
Congress Must Ask Hard Questions At Climategate Hearing or Risk Further Erosion of Public Confidence in Climate Predictions -- Scandal May Have a Silver Lining, Western Business Leaders Say: Shifting Congress' Focus From Punitive Regulation to Technology Incentives
Washington, D.C. (Nov. 30, 2009) -- Congressional investigators must ask tough questions at Wednesday's hearing on Capitol Hill on climate science and the so-called "ClimateGate" scandal if public confidence in climate predictions is to be restored, a coalition Western business leaders warns.
But the Western Business Roundtable also says there may be a silver lining to Climategate: it may force Congress to shift its focus away from punitive climate taxes and regulation toward incentives-based plans to accelerate technology innovation.
"There is no question that the 'Climategate' scandal has seriously shaken the public's confidence in the integrity of the data that powers the computer climate prediction models that, in turn, provide the justification for thousands of government programs and regulations aimed at addressing climate change," said Jim Sims, President and CEO of the Roundtable. "Without a full and transparent accounting of any and all irregularities and data manipulation that may have occurred, public support for action to address climate issues is going to continue to decline."
But, as with any political scandal, there may be a silver lining, Sims said.
"Much of the debate on climate 'solutions' has focused on regulatory threats and taxes and punishment for the fact that we live in a carbon-based society and operate in a carbon-based economy," Sims said. "This scandal may finally wake up Congress, Governors, state legislators and all policymakers to the fact that the challenge of reducing emissions across the spectrum isn't a regulatory challenge. It's a technology challenge."
"Congress needs to start offering some serious carrots for technology development rather than brandishing a heavy stick of regulation and taxes," Sims said. "If American history shows anything, it is that incentives are a much more efficient path to technology innovation."
"After all," he added, "we didn't land a man on the moon in less than a decade by threatening to put engineers in jail if they failed that challenge."
The Western Business Roundtable is a coalition of companies that are working to pioneer a variety of technologies to increase U.S. productivity and job creation while putting the nation on a glidepath to reduced emissions of all kinds.
Sims said the leaders of the U.S. House Select Committee on Energy Independence and Global Warming should seek answers to "tough" questions in Wednesday's hearing and use the hearing as a platform to call for the following actions:
All raw temperature records and data that has been collected by the Climate Research Unit at the East Anglia center in the UK from the beginning of its work on climate should be immediate released so that scientists around the world can examine the data in detail and seek to replicate the interpretations made of that data. Data checking and replication is a fundamental tenet of the scientific method, Sims said.
A full accounting should be provided of any and all data destruction and/or manipulation that was done by scientists at the center.
A full accounting should be made of any and all attempts to corrupt the peer review process connected with the review of data regarding climate science.
An independent audit should be conducted of all sources of funding that supported the work at the East Anglia CRU and of the individual scientists that work in conjunction with the center. According to the CRU, its work is funded through "external contracts and grant from academic funding councils, government departments, intergovernmental agencies, charitable foundations, non-governmental organisations, commerce and industry."
"Only when all information is made publicly available and full discovery is completed in these critical areas will the public's confidence begin to be restored in the work that has been done by climate scientists and by the IPCC," Sims warned. "In the absence of such disclosure, the cloud that has descended over climate science and IPCC computer models will only get worse."


Bunny Blends are carefully handcrafted blends designed to help supplement your rabbit's diet. My rabbits have eagerly helped me develop each blend to not only be nutritious and helpful, but to appeal to rabbit appetites as well.
Packages are $5 each and packed by volume. I am always happy to barter. See my ISO page for ideas. I mix them in small batches, so please contact me for availability if you are looking for something specific. Shipment can be arranged.
Digestive booster blend great for weaning or to tempt rabbits off their feed. May also be used as an herbal treat.
Blend intended to help alleviate gas buildup in rabbits.
Supportive blend to aid rabbits being treated for coccidiosis in conjunction with medication. Does not treat cocci.
Blend designed to help with healing from wounds or injuries.
Delicious, nutritious treat blend designed for rabbits!
Fertility blend designed to help make your rabbit eager to breed as well as help your rabbit be more fertile. Good for bucks and does.
Blend designed to ease and support expectant mothers.
Blend designed to boost milk production. Do not feed to pregnant does.
Blend designed to decrease milk production, especially useful when weaning kits or if a doe loses a litter. Do not feed to young kits.
Blend designed to reduce stress and calm rabbits. Useful when transporting, showing, and at other times of high stress.
Offer Bunny Blends in a small dish. Rabbits will pick through and take what they need instinctively. Remove any uneaten portion daily and replace. Adding Bunny Blends to your rabbit's feed may cause your rabbit to dig out feed in order to get to the good bits. Bunny Blends can be combined if desired.
Alternatively, Bunny Blends may be brewed into a tea, allowed to cool, and added to water bottles or bowls. Bunny Blends teas may also be syringed into a rabbit's mouth (as in the case of Bloat Buster and Cocci Support).


Recently, I had the opportunity to train a bunch of movement teachers from across the globe. They were accomplished teachers of a movement modality that draws from both ancient and modern forms. They aren't yoga teachers exactly, but they know yoga in their bodies. I was asked to teach them traditional aspects of yoga through the lens of their lives. And so, that's what I did. I realized in the midst of it, that what I was teaching them, so many students and teachers of yoga might also enjoy as a little refreshment… So here are 13 "Pearls of Wisdom" as seen through the lens of Yoga. Enjoy… (and take little bites)!
13. Yoga always asks from you, and gives back to you these three precepts: free & easy breath, long neutral spine, & a relaxed body.


text:
Q: prototype for function does not match any in class C++ I keep getting an error that says "prototype for 'void Engine::start(Tank&)' does not match any in class 'Engine'" Additionally, it says "'Tank' has not been declared," all of which are at the same function 'start' in the Engine class.
    //Engine.h
    #ifndef ENGINE_H
    #define ENGINE_H

    using namespace std;

    class Engine {
    public:
         Engine(int);
         ~Engine() {};
         void setTrip(int tr);
         int getTrip();
         bool isStarted();
         void start(Tank &inTank);
         void stop();
     protected:
         bool started;
         int trip, numCyl;
     };

     #endif /* ENGINE_H */

    //Engine.cpp
    using namespace std;

    #include "Engine.h"
    #include "Tank.h"

there is more to this .cpp but this is the function where the error is
happening.
    void Engine::start(Tank &inTank) {
           if(inTank.isEmpty()) {
                 cout << "Engine cannot start\n";
                 started = false;
           }
           else {
                 cout << "Engine started\n";
                 started = true;
           }
     }

and my main here is used for testing these two classes.
    #include "Tank.h"
    #include "Engine.h"
    #include <cstdlib>

    using namespace std;

    int main()
    {
         Tank t(12);
         Engine e(4);
         e.start(t);
         e.stop();
         t.refuel();
         e.start(t);
         e.stop();
         return 0;
     }

and I'll add my Tank class.
    #ifndef TANK_H
    #define TANK_H

    using namespace std;

    class Tank {
          public:
               Tank(float);
               virtual ~Tank();
               void consumeFuel(float);
               float getFuel();
               virtual void refuel();
               bool isEmpty();
               int getNumTanks();
               float getTankCapacity();
               void setFuel(float fl);
          protected:
               static int numTanks;
               const float tankCapacity;
               float fuel;
               bool empty;
          };

          #endif    /* TANK_H */

Tank.cpp
     using namespace std;

     #include "Tank.h"
     #include "Engine.h"

     //creates tank with certain capacity taken from parameter.
     Tank::Tank(float inCap) {
            Tank::tankCapacity(inCap);
     }

     //I completed the rest of the functions with no errors... so far.lul

A: Whenever class is being used by Reference or Pointer in header, than you need to forward declare that class rather than including entire .h file.
So in your case, you just need to forward declare class Tank in Engine.h and include Tank.h in Engine.cpp.
    //Engine.h
    #ifndef ENGINE_H
    #define ENGINE_H

    //Forward Declaration
    class Tank;

    using namespace std;

    class Engine {
    public:
         Engine(int);
         ~Engine() {};
         void setTrip(int tr);
         int getTrip();
         bool isStarted();
         void start(Tank &inTank);
         void stop();
     protected:
         bool started;
         int trip, numCyl;
     };

     #endif /* ENGINE_H */

A: Move the Tank class declaration above the Engine class


What if you have completed the Agent install but forgot to note the Agent Serial number? What if you're worried that you neglected to check the box so the public key wasn?t installed? You can always check the status of your Agent.
Start in a terminal window.


text:
Yesterday's Gallery and Babylon Revisited Rare Books
author: NAZI GERMANY ALBUMS
1. NAZI GERMANY ALBUMS. Collection of Six Photograph Albums: Germany During Nazi Era, World War Two Germany, Dresden Zoo, Netherlands, Peasant Captives, Dead Bodies. 1940.
A Collection of 6 German family photo albums during the Nazi era. Various sizes. Contain over 1,000 black and white photographs and travel postcards. Contains some photos of persons in Nazi uniform. Both albums chronicle site-seeing and vacations. Many of the albums are notated with location and dates. These albums give an excellent portrait of Germany during the early days of World War Two. One album has extensive photos of Dresden (including photos of the Dresden Zoo) before the bombing: this album's second half follows one Manfred Schimmeck as he goes into military service during the Nazi regime. Some of the albums also contain loose photographs. Excellent glimpse into the daily life of the German people during the Nazi era. The Manfred Schimmeck Album contains a series of photos taken in an unidentified location (possibly the Nazi invasion of the Netherlands), and may depict war atrocities. The village depicted is not Germany and the subjects appear to be peasant captives including women, children and the elderly. A distinguishing feature of this rural village is a tattered windmill. There is at least one photo that shows multiple dead bodies left in what seems to be a ditch, possibly where they fell trying to defend against the Nazi's entering their village - this photo also seems to show a Nazi horse soldier leading what may be a deportation. Item #34158
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2. PHOTO ALBUMS - NAZI ERA GERMANY. Collection of Five Photograph Albums of Nazi Soldiers, Family Life, Adolph Hitler, Hitler Youth, Officers. [Germany]: No Publisher, 1940.
This collection of five personal Nazi era photo albums contain over 400 black and white photos - including 2 candid photos of Adolf Hitler (never published). The group consists of 3 full-sized oblong canvas fabric covered albums, and two miniature photo books. The larger sized albums contain photos of: Nazi Youth camps (Boys Hitler Youth, RAD, and BDM); uniformed Nazi officers; photographs of children in group training and excursions; and athletic exercises showing both very young boys; as well as excellent shots of girls of the BDM in iconic athletic exercises. NOTE: The leather covered miniature album seems to belong to a particular Nazi soldier and contains a range of subjects including two candid photos that could be considered indecent (one can be considered pornographic). Item #34160
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