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A sub-phenotype approach to dissect the genetic control of murine type 1 diabetes
Bergman, Marie-Louise
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology).
The non-obese diabetic (NOD) mouse is a model for human type 1 diabetes (T1D). The disease in the NOD mouse is polygenic and multifactorial and so far at least 20 insulin dependent diabetes (Idd) susceptibility loci have been identified. However, no etiological mutations have been definitely ascribed to the Idd loci. To identify potential etiological mutations, a sub-phenotype approach was undertaken, consisting of the establishment and genetic mapping of immuno-related sub-phenotypes that may contribute to the pathogenesis of T1D in the NOD mouse model. This thesis presents (1) the results of the identification and genetic mapping of four novel NOD immuno-phenotypes to individual Idd loci, and (2) confirmation of these results by the generation and analysis of congenic strains covering those Idd regions.
Evidence is provided that gene(s) within the Idd5 region control cyclophosphamide (CY)-induced apoptosis in peripheral lymphocytes and y-irradiation induced apoptosis in NOD thymocytes. Analysis of non-obese resistant (NOR) and NOD-Idd5 congenic mice reveal that CY-induced apoptosis in peripheral lymphocytes and y-irradiation induced apoptosis in thymocytes are controlled by a 20cM and a 6cM region, respectively, both containing the Idd5 region and including the immuno-regulatory Ctla4 gene. Additionally, CTLA4 is shown to be defectively up-regulated in activated NOD peripheral lymphocytes, and CTLA4-deficient mice show similar defects in T cell apoptosis induction. Taken together, these results suggest that a defective up-regulation of CTLA4 mediates apoptosis resistance, contributing to diabetes pathogenesis.
Moreover, it is shown that gene(s) within the Idd6 region control low proliferation ofNOD immature thymocytes and resistance to dexamethazone-induced apoptosis in immature DP thymocytes. The decrease of diabetes incidence and the restoration of the apoptosis resistance phenotype in reciprocal Idd6 congenic strains further restrict the chromosomal region controlling the Idd6 locus as well as the locus controlling the apoptosis resistance phenotype. In fact, analysis of NOD-Idd6 congenic mice reveal that Dxm-induced apoptosis in thymocytes is controlled by the distal 3cM region of the Idd6 locus. As the thymic selection process is highly dependent on both proliferation and apoptosis, the hypothesis is raised that the Idd6 locus contributes to the pathogenesis of diabetes by altering thymic selection, resulting in an autoimmune prone peripheral T cell repertoire.
Umeå: Umeå University , 2002. , p. 62
Endocrinology and Diabetes Cell and Molecular Biology
URN: urn:nbn:se:umu:diva-148283ISBN: 91-7305-257-4 (print)OAI: oai:DiVA.org:umu-148283DiVA, id: diva2:1211911
2002-05-02, Lecture Hall "Major Groove", Dept. of Molecular Biology, Umeå, 10:00 (English)
Andersson, Leif
Swedish University of Agricultural Sciences, Uppsala.
digitalisering@UmU
1. Apoptosis resistance of nonobese diabetic peripheral lymphocytes linked to the Idd5 diabetes susceptibility region
Open this publication in new window or tab >>Apoptosis resistance of nonobese diabetic peripheral lymphocytes linked to the Idd5 diabetes susceptibility region
Colucci, Francesco
Penha-Gonçalves, Carlos
Cilio, Corrado M.
Holmberg, Dan
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
Show others...
1997 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 94, no 16, p. 8670-8674Article in journal (Refereed) Published
Defects in lymphocyte apoptosis may lead to autoimmune disorders and contribute to the pathogenesis of type 1 diabetes. Lymphocytes of nonobese diabetic (NOD) mice, an animal model of autoimmune diabetes, have been found resistant to various apoptosis signals, including the alkylating drug cyclophosphamide. Using an F2 intercross between the apoptosis-resistant NOD mouse and the apoptosis-susceptible C57BL/6 mouse, we define a major locus controlling the apoptosis-resistance phenotype and demonstrate its linkage (logarithm of odds score = 3.9) to a group of medial markers on chromosome 1. The newly defined gene cannot be dissociated from Ctla4 and Cd28 and in fact marks a 20-centimorgan region encompassing Idd5, a previously postulated diabetes susceptibility locus. Interestingly, we find that the CTLA-4 (cytotoxic T lymphocyte-associated antigen 4) and the CD28 costimulatory molecules are defectively expressed in NOD mice, suggesting that one or both of these molecules may be involved in the control of apoptosis resistance and, in turn, in diabetes susceptibility.
National Academy of Sciences, 1997
urn:nbn:se:umu:diva-148282 (URN)10.1073/pnas.94.16.8670 (DOI)A1997XQ12400068 ()9238035 (PubMedID)
2. CTLA-4-/- mice display T cell-apoptosis resistance resembling that ascribed to autoimmune-prone non-obese diabetic (NOD) mice
Open this publication in new window or tab >>CTLA-4-/- mice display T cell-apoptosis resistance resembling that ascribed to autoimmune-prone non-obese diabetic (NOD) mice
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology). Instituto Gulbenkian de Ciencia, Oeiras, Portugal.
Cilio, Corrado M
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM). Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Endocrine Research Unit, Wallenberg Laboratory, Malmö University Hospital MAS, University of Lund, 205 02 Malmö Sweden.
Lamhamedi-Cherradi, Salah-Eddine
INSERM U25, Hopital Necker, Paris, France.
Löfgren, Anna
Lejon, Kristina
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology).
Garchon, Henri-Jean
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Instituto Gulbenkian de Ciencia, Oeiras, Portugal.
2001 (English)In: Journal of Autoimmunity, ISSN 0896-8411, E-ISSN 1095-9157, Vol. 16, no 2, p. 105-113Article in journal (Refereed) Published
The genes conferring susceptibility to autoimmune (insulin-dependent) diabetes mellitus (IDDM) are, in most cases, not defined. Among the loci so far identified as associated with murine IDDM (Idd1-19), only the nature of Idd1 has been assessed. Here we show that thymocytes and peripheral lymphocytes of the non-obese diabetic (NOD) mouse are relatively resistant to apoptosis induced by gamma-irradiation. By linkage analysis of F2 progeny mice, we map this trait to a locus on chromosome 1 containing the Idd5 diabetes susceptibility region. By the use of congenic mice, we confirm the linkage data and map this locus to a 6 cM region on proximal chromosome 1. Ctla4, being localized in this chromosomal region and mediating crucial functions in T cell biology, is a logical candidate gene in the Idd5 susceptibility region. In line with this, we demonstrate that T cells from Ctla4(-/-)deficient mice show a similar resistance to gamma-irradiation-induced apoptosis as observed in the NOD mice. This reinforces the notion that CTLA-4 contributes to the pathogenesis of autoimmune diabetes.
Elsevier, 2001
urn:nbn:se:umu:diva-87510 (URN)10.1006/jaut.2000.0474 (DOI)000167547100003 ()11247636 (PubMedID)
3. Diabetes protection and restoration of thymocyte apoptosis in NOD Idd6 congenic strains
Open this publication in new window or tab >>Diabetes protection and restoration of thymocyte apoptosis in NOD Idd6 congenic strains
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
Duarte, Nadia
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM). Instituto Gulbenkian de Ciencia, Oeiras, Portugal .
Campino, Susana
Instituto Gulbenkian de Ciencia, Oeiras, Portugal .
Lundholm, Marie
Motta, Vinicius
Instituto Gulbenkian de Ciencia, Oeiras, Portugal.
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM). Instituto Gulbenkian de Ciencia, Oeiras, Portugal.
2003 (English)In: Diabetes, ISSN 0012-1797, E-ISSN 1939-327X, Vol. 52, no 7, p. 1677-1682Article in journal (Refereed) Published
Type 1 diabetes in the nonobese diabetic (NOD) mouse is a multifactorial and polygenic disease. The NOD-derived genetic factors that contribute to type 1 diabetes are named Idd (insulin-dependent diabetes) loci. To date, the biological functions of the majority of the Idd loci remain unknown. We have previously reported that resistance of NOD immature thymocytes to depletion by dexamethazone (Dxm) maps to the Idd6 locus. Herein, we refine this phenotype using a time-course experiment of apoptosis induction upon Dxm treatment. We confirm that the Idd6 region controls apoptosis resistance in immature thymocytes. Moreover, we establish reciprocal Idd6 congenic NOD and B6 strains to formally demonstrate that the Idd6 congenic region mediates restoration of the apoptosis resistance phenotype. Analysis of the Idd6 congenic strains indicates that a 3-cM chromosomal region located within the distal part of the Idd6 region controls apoptosis resistance in NOD immature thymocytes. Together, these data support the hypothesis that resistance to Dxm-induced apoptosis in NOD immature thymocytes is controlled by a genetic factor within the region that also contributes to type 1 diabetes pathogenesis. We propose that the diabetogenic effect of the Idd6 locus is exerted at the level of the thymic selection process.
American Diabetes Association, 2003
Immunology in the medical area Endocrinology and Diabetes
urn:nbn:se:umu:diva-4715 (URN)10.2337/diabetes.52.7.1677 (DOI)000183838900013 ()12829632 (PubMedID)
4. Low rate of proliferation in immature thymocytes of the non-obese diabetic mouse maps to the Idd6 diabetes susceptibility region
Open this publication in new window or tab >>Low rate of proliferation in immature thymocytes of the non-obese diabetic mouse maps to the Idd6 diabetes susceptibility region
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
Gulbenkian Institute for Science, Oeiras, Portugal, PT.
2001 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 44, no 8, p. 1054-1061Article in journal (Refereed) Published
Aims/hypothesis: The non-obese diabetic (NOD) mouse spontaneously develops T-cell-dependent autoimmune diabetes. This mouse strain has a number of immune dysfunctions related to T-cell development but so far there are no available data on the proliferation of NOD immature thymocytes. We therefore studied the thymocyte proliferation in the NOD mouse in discrete stages of T-cell development.
Methods: We depleted thymocytes in vivo and analysed thymocyte proliferation during the thymus recovery from depletion. We used co-segregation analysis and quantitative loci trait analysis to investigate the genetic control of proliferation impairments in NOD thymocytes.
Results: Immature thymocytes of female NOD mice proliferate with a relatively low rate compared to non-autoimmune C57Bl/6 mice. This aberrant proliferation was most pronounced in CD4– /loCD8+ cells differentiating from the CD4–CD8– to the CD4+CD8+ stage. A genetic mapping study using an F2 intercross between the NOD and the C57BL/6 strains showed that a major locus controlling this trait is linked to the insulin-dependent diabetes susceptibility locus Idd6.
Conclusion/interpretation: Our results suggest that impairment of proliferation of immature thymocytes is one possible mechanism through which the Idd6 locus contributes to the pathogenesis of diabetes.
NOD, immature thymocytes, proliferation, genetics
Endocrinology and Diabetes Immunology in the medical area
urn:nbn:se:umu:diva-87518 (URN)10.1007/s001250100600 (DOI)000170686800016 ()11484085 (PubMedID)
2e6b964f5af103849ef835f4540d7471ceb07b09df53cc2a3ee8d8f30e05dc63f5eb770111badcbee5c5f6d21d7ccf495b5ed123aa1ff428a47179d83be490e3
Department of Molecular Biology (Faculty of Medicine)Department of Molecular Biology (Faculty of Science and Technology)
Endocrinology and DiabetesCell and Molecular Biology

redpajama_set_name: RedPajamaCommonCrawl


There was no leap second added at the beginning of 2004!
This is a sign that the Earth's rotation is currently a little faster than expected. In modern times, a leap second is needed every 500 days or so. This keeps our atomic clocks in sync with the earths rotation, which is slightly longer than 24 hours.
But the last leap second we had was at the beginning of 1999. Scientists are a little puzzled by this. In general the earth is slowing down it's rotation. Some theories to account for the current speed up are: position of other planets in our solar system, and current weather changes.
Maybe Global Warming is causing more change to our Earth than I thought!
Posted on Monday, 5 January 2004 5:05 p.m.
I think that the world is spinning faster because the giant gnomes that control the rotation of the planets have been drinking heavily and are not paying attention to their jobs.
Either that or it is a plot by a group of potheads from Bakersfield, CA to get a better buzz off their weed.
i think the tsunami had something to do with this.
I think it is the gnomes.
hi everyone, i'm sitting here in the lovely (haha) little country of Britain, it's 3:20 in the morning and its getting light outside, in fact its really light, hmm, now this time of year im pretty sure its not meant to get light until 4:30(ish) or later, and it's only been like this this year, and its definatley not zodiacal light, its proper sunlight, so maybe this whole theory is true, who knows.
the gnomes are all powerful! they will all force the earth to spin faster until the centripital force throws the atmosphere nd ourselves out of orbit...wait! that's me too! screw the gnomes, and i'm leavin' before...someone's comin'. hey! who the heck are you?! what the...nooooo!....................YOU HUMANS ARE NO MATCH FOR US! HA, HA, HA, HA, HA, HAAA!
Hey there, I believe the real reason has something to do with Bible Prophcy. Jesus Christ said in the book of Matthew chp 24:v22 (speaking about the Great Tribulation)"Unless those days be shortened, no flesh would be saved; but for the elects sake those days will be shortened." Also in the book of Revelation Jesus tell John about the Fourth Trumpet. Rev 8:v12 then the fourth angel sounded: And a thrid of the sun was struck, a thrid of the moon, and a thrid of the stars, so that a thrid of them were darkened. A thrid of the day did not shine, and like wise the night.
My question is do you Know Christ? My pray is you do.
i think its slowin , lets be 4 real peeps!
Hi all I am South Africa, Durban, Yes the earth is spinning faster, NASA has 12 earthologists working on ways to stop this from happening, Its seems that has much has we try to find ways to stop the earth from spinning faster then normal we are not Gods and we can always find ways to make earth suit us but we cannot control earth.
The Earth is spinning faster because their is a secret cult of over 1 billion people who always run in one direction at an established time of the day.
ohh no, like everything, it is the global financial crisis to blame for this. We are in these "tough times" right now and they are causing a lot of inconvenient things to happen, including causing the Earth to spin faster. This means everything on Earth is faster. A year now only takes the time of 11 months, but we dont see it because we still experience the same number of days and nights, but the days are shorter and so are the nights. Everything has adapted to the faster time so we dont really notice. TIME IS SPEEDING UP!!!!!! Oh well, happiness can only be felt in the present, and if you spend all your present worrying about making a happier future, you will spend all your present in the future stressing about planning the happiness to come in the future of that future.
I love watching the moom and stars. These days I can stand behind the verandah pole and obscure the moon, and within 1 minute it has moved to where I can see it. Happens with stars too. I guess this can only be the earth moving faster, and my guess is the core of the earth is getting hotter.
It is spinning faster, trust me, I'm the only one left on Earth that is still trustworthy. I never lie. The Earth is also wobbling. The poles are moving. The cause? Again, trust me, you really don't need to know, just make peace with the creator, this is the utmost importance. Trust me.
The scientist can't explain the earth spinning faster because it has nothing to do with theory. The world is going to end.
Well, astro, you finally barked up the wrong tree. I am your boss stupid, stop wasting tax payers money and get in my office right now! You are fired! I always hated you.
From a scientific approach, this speeding up of the Earth's rotation is quite logical. As high school chemistry students would all know, an increase in temperature increases kinetic energy, thus causing particles to speed up. This global warming has undoubtedly caused not only everything within Earth's atmosphere to speed up, but also the planet's rotation.
No wonder kids are growing up too fast!


Today, Mafia III's Family Kick-Back Pack is available in your platform's digital store. And to celebrate, developer Hangar 13 released a new trailer highlighting the extra goods.
The pack — which was previously exclusive to people who preordered the game — contains three custom guns and three custom guns.
The guns will be available as soon as Cassandra joins your crew in the game. From there all you will need to call the Arms Dealer – and three new weapons will be at your disposal.
As for the cars, once Burke joins your crew, you will have the three cars added to your Vehicle Delivery service.


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Home Municipal News Make A Difference in Your City; Hollywood Seeks Advisory Board Applicants
Make A Difference in Your City; Hollywood Seeks Advisory Board Applicants
If you have lots of ideas about how things could be better in the City, here's a great opportunity for you to be heard, and maybe see your thoughts put into action. The City of Hollywood is seeking applicants to serve on various Boards and Committees on a voluntary basis. The deadline for applications is April 19.
The Office of the City Clerk is currently accepting applications for vacant or expiring positions that exist on the following committees and boards:
African American Advisory Council
Age-Friendly Community Task Force
Artwork Selection Committee
Community Development Advisory Board
Dune Master Plan Task Force
Education Advisory Committee
Employees' Retirement Plan
Green Team Advisory Committee
Historic Preservation Board
Hollywood Housing Authority
Marine Advisory Board
Neighborhood Watch Advisory Board
Parks, Recreation and Cultural Arts Advisory Board
Planning and Development Board
Unsafe Structures Board
Young Circle ArtsPark Advisory Board
There are specific requirements for each board or committee. You can apply online or get more information on the City's website here.
All completed interest forms must have a resume attached and be returned to the Office of the City Clerk at Hollywood City Hall, 2600 Hollywood Boulevard no later than 6 pm on Thursday, April 19. Appointments will be announced by the City Commission on May 22 at 3:30 p.m.
For additional information, please contact the Office of the City Clerk at 954-921-3211.
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This entry was posted on Friday, January 6th, 2012 at 14:35 and is filed under Barack Obama, Breaking News, Call To Action, Law, Media, Politics.
Barack Obama's tyrannical actions must be challenged. This is going to be in the form of what Donald Rumsfeld once explained when he said to cat-calls: "You go to war with the army you have – not the army you might want or wish to have at a later time." We are now in that sort of fix. John Boehner is a weak leader, at least in terms of his willingness to make waves or engage in battle, but this is no time for whimpering. President Obama has openly declared by his actions of Wednesday that the Constitution is fungible, and that he has no need to obey it due only to a technicality otherwise known as the law. This cannot be permitted to go without challenge, and whether the United States Senate will take it up or not, the Speaker of the House must move to begin impeachment proceedings on the basis of Barack Obama's willful disobedience of the US Constitution. Members of Congress must assemble to denounce him, and this must be brought to the light of day. What Barack Obama has hereby argued is that the constitution only matters when he permits it to be the controlling legal authority, but that in all other cases, it is secondary to the whims of his willingness to enforce or abide by the law.
If you haven't kept up with this issue, or like so many, haven't heard a peep about it, let's make it simple to understand: What's at stake is our constitutional form of government, and the checks and balances about which you may have been taught when you were a child in school. Those checks and balances provide that presidents do not possess unlimited authority to act without reference to the other co-equal branches of government. What the President has done in this case is to make a "recess appointment" without the Senate actually being in recess. In so doing, he is violating the law, and he has more than one motive with this plot. Obama intends not only to give a new hand-out by virtue of mortgage write-downs for qualified persons, but also to set the precedent for undermining all law.
This is extraordinary, and for the President to undertake this action is a treason against the United States Constitution. What he is attempting to do is to pull the rug out from beneath his opponents by buying off enough of the electorate to swing the vote in his direction, and he's willing to violate the law to carry it out. This sort of reckless indifference to the rule of law is unprecedented in American history, and it cannot be stated loudly enough or often enough that it must be opposed by every American, but particularly our political leadership. This demonic assault on the separation of powers embodied by our Constitutional Republic must not be permitted.
Congress must act. We haven't the luxury of waiting for an election. Every member of Congress must stand and in one voice denounce this violation of law. Every American should be upset by this, because what it means is that one man, Barack Obama, has arrogated to himself the power of law. Ladies and gentlemen, let none persuade you that this had been a trivial matter. Presidents swear an oath to uphold the Constitution, and here, Barack Obama has taken it upon himself to simply ignore the law. At the American Center for Law and Justice has an excellent piece on the specifics here.
Let none be mistaken: Your lives are under attack by this action as surely as by the act of a foreign aggressor. If you're not writing and calling and raising a ruckus, what you're doing is to participate in the surrender of our nation. This isn't just another act by Obama in defiance of some statute, or some judge's ruling, all of which are bad enough to impeach him, but instead a direct head-on assault upon your US Constitution. Why do so many shrink from this? I realize the media is downplaying it for the most part, so it's not really caught on with most people who aren't even aware of the situation, much less its details. This, I submit to you, is when you can be most effective if you're inclined to fight for your country. Pick up the phone, call your Representatives and Senators, call your friends and family, and call anybody you know who will give you a few minutes of their time.
Explain to them the simple facts, direct them to the ACLJ link above, and make it known that this is a serious issue with which we must contend. I read many oaths in the comments section, some of which do not get published because they're too profane, but a constant theme is how you will fight for the country. This is one of those times. It's Friday, and the press is putting the week to bed, but if you wanted to, by Monday morning the country could be a sea of uproar over this issue, with or without the media's reporting.
I have long feared that for too long, this nation has suffered a surplus of sports fans and a dearth of active citizens. I would hate that my surmise had been proven correct over an issue of such glaring national effect. Will we have the rule of law, or the rule of one man? It's time for you to decide. It's time for you to place those calls. It's time to make the start of a resistance to a growing, grasping dictatorship. Unopposed, he will grow to love his newly discovered power, and he will make ever greater use of it.
Yes. I will. I cannot think of anything else I can do, yet.
Anton, Clearly, you need to pull back a little. Obama received a Nobel prize because he's a leftist, and the Nobel committee favors leftists, and because they felt like he deserved it due purely to his race. Think of it as an "affirmative action Nobel prize," because otherwise, the award to Obama is inexplicable. He had done nothing to earn it.
As for Rumsfeld, my reason for quoting him was because of what he said, and its usefulness in the article I was writing. I take it most other readers of my site were able to grasp that concept. Since it's clear you were somewhat confused, let me see if I can help: I was making the point that although Boehner is a weak leader, he's the leader we have in the House of Representatives, and when you are compelled to confront an issue, politically or militarily, you must engage with what you have at the time. That was Rumsfeld's point about the Army at the time he made that statement, meaning he may have wished to have a different composition of the force structure, but you don't necessarily have the luxury of retooling your forces as you go to war. In short, you "go to war with the Army you have."
Now, as for Obama and international law, he's done nothing of the kind, since, as you've noticed, G'tmo is still open. Now please take your sycophantic support for Obama and leave. He's currently engaged in treasonous disregard for the rule of law, and apparently, you support it. Bye!
THAT is the warrior I've come to see on these pages. GREAT rally cry and I am with you!!
Wish I could say more than…don't hold your breath.
Already emailed my friends and hopefully they will pass it on. I do not have high hopes. The majority of people just don't care, Mark. How do we fight apathy? I will call my reps but expect the same.
This is being thrown right in congress' face and nothing from them. What in the world are they getting for this? I just cannot come up with a reason for why they are letting Obama get away with this unless there is something huge in it for them. Can we believe that every single one of them is too cowardly to fight this? I just don't know any more what the answer is to this.
Tracy, it has been my thought before and now, that , either they are getting a bundle of fake money, or are being threatened.
The "revolutionaries " have said before, those who will not adjust to new ways will have to die.
They are capable of anything.
patriotsoul, I'm wondering about threats also. I keep hearing that they don't dare because of charges of racism. It just seems that all they're good at is curling up in a corner and covering their heads. Disgusting! They're all treasonists as far as I'm concerned.
Some of our reps are alredy on it. Let's make sure we support them.
Indeed, those that are on the job should get our support. Those who aren't or are timid should hear from us.
Which reps are on this. I have no idea so I would like some names. I will make sure they hear from me.
Just emailed Louie Gohmert and John Cornyn's offices. (Not sure if Kay Bailey is even working anymore – have not had much luck getting anything out of her in the past so I didn't bother with that one….) Sure hope somebody does something. Gohmert is a lawyer, former judge and a very conservative constitutionalist. He will usually stand up and fight for what he thinks is right regardless of what people think of him too, so maybe he'll take this on.
Now (smile) This is the Mark that has me coming back over and over to read his words. Yes, all of us should be angry, MORE than ANGRY! email, call and fax our congressmen, senators and friends of this Constitutional offense!
Hope your challenge here gets the response it should. I'd already called and sent emails to a number in Congress, though my particular Rep is a democrat, so I don't expect any help there – which is why I've contacted a number of others, incl both our Senators.
PS – I've already long thought our leaders should have challenged bho and his administration on a number of things and that our courts should have as well. I am mightily displeased with many of our supposed leaders.
Bob, With good reason sir. We should be asking those who claim to support the Constitution and the rule of law when they will begin supporting them when they are under direct attack.
Remember, Mark, these are just claims on their parts. When they take the oath I doubt more than 10% support the Constitution anymore. If they were Constitutionalists they would be fighting the dictator wannabe tooth and nail. If they don't support it and we can't get them out what then?
Yes, what is the point of sending our young men to fight and die for freedom overseas when we so callously ignore assaults on our freedom here at home?
I have long feared that for too long, this nation has suffered a surplus of sports fans and a dearth of active citizens.
Or playing the latest video games. Ugh.
It is my hope , the men / women who have returned will also defend us against the onslaught of criminals in our government.
I have seen posts of attempts will be made to indoctrinate them against us.
We must work more quickly.


Public Factory, which aims to help emerging designers, will open at the SoHo Grand Hotel.
One entrepreneur is setting out to help new designers who are eager to open their own retail stores but less enthusiastic about having to commit to long leases and pay expensive rents.
Earlier this year, Yazid Aksas founded Public Factory, which leases large spaces and subdivides them for short-term rental to emerging designers. Mr. Aksas' first venture will open at 310 W. Broadway, between Grand and Canal streets, on Sept. 22. It will house his own menswear label, Beau.com, and the wares of 11 other designers, with a focus on menswear.
"The terms and conditions to open your own store are so out of whack compared to what most people can afford," said Mr. Aksas, who experienced the difficulties firsthand when he opened Beau.com two years ago at 311 W. Broadway, noting that most landlords expect 10-year leases and tenants also have to contend with hefty construction costs. He added that pop-up stores are simply too short term in nature. The label will move into the Public Factory space at 310 W. Broadway when it opens.
At Public Factory, a dozen labels will share 3,300 square feet. Similar to a shared co-working space such as WeWork (where Mr. Aksas and his four co-workers headquarter their company at 222 Broadway), members pay a monthly fee—$3,000, in this case—for about 100 square feet. Brands must commit to three months.
"We are the ones taking the risks—we build the space and manage it, pay electricity and Internet and those things designers don't want to deal with," said Mr. Aksas. "They just have to worry about the product and brand marketing."
Mr. Aksas leases the retail space from the SoHo Grand Hotel, which will offer an entrance to Public Factory in addition to a street-side entryway. He has signed on for a 10-year deal for the property. A representative from the SoHo Grand did not return a request for comment.
In the coming months, he plans to open a similar WeWork-like space in SoHo for womenswear labels only, and already has about 25 brands on a wait-list, he said.


USA Today has an article discussing the Norwood eminent domain case. Regular readers of this website know by now that the Ashbrook Center (along with former State Representative William Batchelder) filed a brief in Norwood arguing that the Ohio Constitution prohibits using eminent domain in a non-blighted area to transfer property from one private owner to another. Of course, that is the relevant legal question raised by the Norwood case: May local governments in Ohio take non-blighted private property for the purpose of transferring it to another private owner?
USA Today, which states that "the neighborhood doesn't appear blighted," is merely confirming the obvious. According to the article, Joseph Horney purchased his Norwood home for $63,900 in 1991. The home is currently valued at more than $230,000. I wish we all lived in areas that were "deteriorating" so rapidly.
Not having seen your posts for awhile, I was wondering whether we were keeping you too busy with Civ Pro!


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Led by Bryan Del Rosario, Staff Counsel for the Council on Foundations, and Lindsay Mason, Director of Corporate Philanthropy, this workshop is organized to ensure common legal questions for administering grants, board governance and charitable giving activities are addressed. Bryan will provide technical and practical understanding of complex rules and regulations impacting private and corporate foundations/giving programs.
The Council's legal team will tailor each session to emphasize the issues most frequently addressed in their interactions with private foundations and corporate grantmakers. Sessions will be structured to ensure there will be time for questions and an in-depth discussion of the answers.
This workshop is open to any of the following employees eager to dive into the legalities of charitable activities, develop a better understanding of the law and unlock effective management and leadership tools of private and corporate foundations/giving programs.
Thanks to Wells Fargo Regional Foundation and Southern California Grantmakers for co-hosting this event with the Council on Foundations.
Specific topics will be defined in advance of the workshop as attendees begin to submit ideas, pressing issues, and assist with the defining of sessions. This event is designed to be time sensitive and relevant to current issues. The format will be discussion-oriented, question and answer-based learning.


St. Peter is a small town in the central part of the Adriatic coast (Riviera Biograd), with beautiful views of the island of Pasman and Pasman Channel. Location is especially suitable for those who want to spend a holiday familiar in silence and tranquility.
Environmental home a yard of richly decorated with Mediterranean plants such as the olive, fig, pomegranate, laurel, mandarin, rosemary and various flowers.
In this environment, the open space, there is a large round stone table capacity of 8 to 10 people. Near the stone table is universal grill. The yard is large enough that the contents mentioned above provides space for play and sunbathing "
The house with 2 terrace is about 100m2 and consists of two floors with sea view. Distance from the sea is 70m.
Guests can use the universal grill, internet access, table tennis, bowling and hanging electronic darts. The house is air-conditioned and equipped with a washing machine and dishwasher, microwave and other small kitchen appliances.


Disable all your browser extensions/add-ons.
Browser exceptions can cause odd, slow, or broken behavior. If you use Chrome, try using Tracker in an Incognito window which should disable them all. If you find an extension in any browser that's affecting your use of Tracker, please email tracker@pivotal.io and we can at least help contact the extension's creator to try and get that fixed.
Force reload the page instead of a normal reload of your browser. To do this, go to the page, and in Firefox, Safari, or Chrome, hold down the Shift key while you click page reload, or type CTRL+R or Command+R.
Clear your browser's cache and Tracker cookies.
Check your system date and time and update them if needed. Some errors in Tracker may be caused by your system clock being incorrect.
For any issues using the iOS mobile app, please see Using the iOS app.
What OS/browser/browser version do you use (and is the behavior any different in another browser)?
Did disabling your extensions/add-ons or using a different browser without them help?
Do you or anyone else see the problem on a different machine in your location?
Do you see the same behavior on a different network, such as another office or at home?
If applicable, please provide an ID for a story that demonstrates the problem.
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text:
Al-Futtaim Toyota delivers strong H1 results
By Editor_wr	 Last updated Aug 16, 2019
Al-Futtaim Toyota has registered a strong performance in the first half of 2019, thanks to the launch of a number of new models as well as robust Land Cruiser sales.
Sales increased by 5.4 per cent versus the same period last year – a strong achievement considering the overall non-luxury market dropped by two per cent in 2019.
In the first six months of the year, Al-Futtaim Toyota introduced several new models including the Land Cruiser GTS, the all-new RAV 4 – including a hybrid variant and the region's first hybrid SUV – and the all-new 2020 Corolla which also featured a hybrid variant for the first time ever.
Al-Futtaim Toyota registered sales increase across all categories with Sedan sales increasing by eight per cent, SUVs growing by two per cent and Light Commercial Vehicles (LCV) registering an increase of six per cent when compared to the first six months of last year. Hybrid sales, which include models such as the Prius, Camry, Corolla and the RAV 4, were up by 80 per cent in H1.
The launch of the new hybrid models reaffirms the market's growing appetite for environmentally-friendly mobility solutions. Next year, Al-Futtaim Toyota will be introducing additional Hybrid models giving customers the opportunity to contribute to a greener, healthier planet for generations to come.
"Our H1 performance is the result of our customer-centric approach and our strong product line-up. In the first half of the year, we've refreshed our line-up with the introduction of several new models and also launched a number of initiatives such as the Rewards Card programme, Personal Contract Purchase (PCP) offer, as well as our current tactical campaign that gives our customer the opportunity to buy now and pay in 2020. All these efforts have helped Toyota retain its top spot as the automotive brand of choice in the UAE," said Saud Abbasi, Managing Director of Al-Futtaim Toyota.
"For the second half of the year, we have more exciting all-new model launches planned and we remain confident of closing out the year successfully," he added.
According to a recent survey by YallaMotor – a leading regional automotive portal, Toyota enjoyed double the audience of its closest rival in the UAE. The survey also revealed that the iconic Land Cruiser was still the most popular model in the country.
Source: Khaleejtimes
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SABIS® to Use Huawei's Wi-Fi Solutions for Its School…


US$ 950 / person ?
2 Tashigang – Merak Today you will change the car for hardy Bolero jeep and start early in the morning ascending to high mountains of Merak – Sakteng, so called Migoi national park. Migoi is local name for elusive yeti and most local inhabitants will be able to remember numerous cases when they or they relatives encountered yeti in the wild. After two hours drive we will reach Mon-la pass where the welcome party of Borkpa nomads in local dress will be waiting. Experience of local hospitality and yummy nomad lunch, the tasty local spirit and milk-like chang beer. Continue drive to Merak village (3500 m) and accommodation in local farmhouse as a guest of Brokpa family. Explore village and witness the performance of Yak dance and then and Aum Yomo (local deity) dance. Sleeping in simple conditions (own sleeping bag is recommended but not necessary).
3 Merak – Sakteng Start 7-8 hours hike over the 4000 meters high Nyuksang-la pass to the large Sakteng village. The trail offers great view back to Merak and lot of opportunity to see various wild animals like blood phesants and similar. After crossing pass there is long descent to river bed and another brief ascent after which the large village of Sakteng becomes visible. This village was not yet reached by motorable road and maintains quite a nice local culture.
4 Sakteng One day exploration around Sakteng, visiting temples above the village and other notable sites around.
5 Sakteng – Tashigang Morning hike around the Sakteng village and then continue hiking to Tharthi. Good bye party at the small pass behind the village and then continue hiking gently downwards to the Tharthi village. Here we will again take Bolero jeep and will go till the paved road and further to the hotel.
6 Tashigang – Samdrup Jongkhar, onward to Guwahati This will be all day drive descend from the Himalayas southwards to Indian border. You will start early in the morning, going the same way you came here on the day one, going around Yongphula airport, Sherubtse university. Don't forget to stop for another blessing at Damthang before reaching Smadrup Jongkhar. After immigration formalities, you will tell good bye to your Bhutanese guide and driver and Indian counterpart will drive you to Guwahati. This is the tour end.
Extend stay in Merak (+1 days): Staying one day in Merak might also be good idea. You can explore the surroundings or try to negotiate holy Aumo Yomo peak (somewhat over 5 thousand meters) or explore village more thoroughly.


To Justify Land was published in a serialized form in Berfrois, and republished in the Media Co-Op. Thank you to Billie Pierre and David Gray-Donald for their close editing of the essays for republication in the Media Co-Op; Shuwei Fang and Berfrois for the first publication of the essays; and Nathan Medema for his support, patience, and encouragement.
There is an important distinction between Indigenous traditional self-governance and government-sanctioned First Nations, which may often differ in their principles in resisting or collaborating with private industry development. Contemporary territorial definitions for First Nations in the eyes of the Canadian state were formed largely following the 1876 "Indian Act," which dismantled traditional systems of governance and subjected Indigenous peoples to dependence on systems of recognition and authorization from the Canadian government. Colonial-delineated First Nations governance, which is typically decided by an electoral system enforced by the Canadian government, tends to hold concentrated forms of power and wealth that are very different from the leadership structures in traditional governments. First Nations often receive both government and industry funding, and receive protected jurisdictions and rights for land-use. By contrast, autonomous, traditional governments like that of Unis'tot'en, represent a traditional way of life, and tend to exercise inherently anti-capitalist values that respect and protect the earth and water. They may not be officially recognized by the Canadian government, and may be in conflict with the priorities of the Canadian government and the First Nations governments and bands accepting what rewards industry dangles in front of them for compliance, partially filling gaping holes in the meager funding distributed by the Canadian state.
On one hand, the urgency of providing for basic living needs that are denied through systemic colonial oppression will coerce First Nations into the acceptance of bribes offered by extractive companies and the Canadian government (explored in sections 2 and 3). One of the arguments being made for First Nations' collaboration with oil companies or other extractive industries is that, facing an apparent inevitability of such projects' approval, First Nations investment would relieve some financial support on the federal government, allowing for communities' self-determination to be more quickly realized. As quoted in an article in the CBC on the Trans Mountain pipeline, Stephen Buffalo of Samson Cree Nation – president and CEO of the Indian Resource Council of Canada – said, "There's a lot of money going through those pipes, and First Nations can't stand to the side and watch it go by" (CBC, Aug. 21, 2017). On the other hand, there are simply inflamed desires for ownership, profits, and participation in the lucrative oil industry, for which identity doesn't stand in the way of bloating profits. In this case, there are projects like the pipeline between Alberta and British Columbia which was proposed by Eagle Spirit Energy Holding Ltd., intended to be twice as long as the rejected Northern Gateway pipeline. The Eagle Spirit pipeline, under company president Calvin Helin, is Indigenous-led, backed by Suncor Energy Inc., Cenovus Energy Inc. and Meg Energy Corp, and intends to overturn a ban on constructing oil tankers along the coast of the Great Bear Rainforest (Financial Post, Nov. 23, 2017, and Financial Post, Nov. 29, 2016).
How fast are we to forget the Oka Crisis? Wherein the Mohawk of Kanesatake, Kahnawake, and Akwesasne resisted the expansion of Club de golf d'Oka over Mohawk burial grounds – a resistance that, under Trudeau Senior's Liberal Government, received a militarized response from Sûreté du Québec (Québec's provincial police), the RCMP, and Canadian Armed Forces. What exactly do these lives mean for those who only see "a lot of money" and are "open for business"?
On June 16, 1959, La Gangrène was bravely published in France for the first time by Jérôme Lindon for Éditions de Minuit, a French publishing house that operated secretly under the Nazi occupation in 1942. La Gangrène documented the tortures endured by Algerians under the hands of French police. On June 20, the book was confiscated by the French government under President—and Minister of Algerian Affairs—Charles De Gaulle. On June 23, French police smashed the plates intended for printing a second French edition. The following spring, New York author and independent publisher Lyle Stuart re-published the book in English, breaking through a state-imposed silence. In France, it would be followed by Henri Alleg's book La Quéstion and critical writings by Pierre Vidal-Naquet, both of whom publically denounced state-sanctioned torture. The censorship of La Gangrène also extended to similar works like Italian director Gillo Pontecorvo's 1966 film, The Battle of Algiers, which was based on the memoirs of FLN leader Saadi Yacef and was banned for five years after its release in France.
The re-publication of La Gangrène in this form is intended as a kind of commemorative edition, not in time with its original publication, but rather in dialogue with the printing date of November 11, 2018 and the printing location of Montréal, Québec. This date commemorates Armistice Day—exactly 100 years ago in 1918—and echoes with the words, Lest we forget . . . French military general Charles de Gaulle was captured by German forces during the First World War and was released on Armistice Day. During the Second World War, Charles De Gaulle would become celebrated as a leader of French resistance against Nazi Germany, and would emerge as the leader of a "Free France".
Under De Gaulle, however, a "Free France" incubated its own racism as these testimonies will show, cultivating anti-Semitism among French police, a hatred towards dark-skinned North African immigrants within France and oppression towards Algerians living under French colonial occupation. De Gaulle also remains a figure celebrated historically and today by Québec nationalists—recalling his speech "Vive le Québec libre" that was given on July 24, 1964 and united nationalist sentiment over another form of French colonial occupation in unceded Indigenous land. Under de Gaulle's government, Algerians fought for independence and attempted a coup, and eventually won their freedom—the universal, basic human right to exist for which, it would seem, the Second World War had been fought.
It becomes even more important to remember narratives such as those of La Gangrène as bigotry and right-wing ideology gain political fervour across Québec and the Americas, police are permitted more abusive powers, and anti-immigrant sentiment becomes policy. So we return to the sentiment that is attached to Armistice Day—what is it we are warned of in the symbolic phrase, lest we forget? We celebrate political leaders as icons of liberation and freedom, we elevate political caricatures and with them discard entire histories.
alethe is published with Italian e-book publisher, Versi Guasti, an imprint of Kipple Officina. The edition is translated from English into Italian by Valerio Cianci, with an introduction by the editor, Alex Tonelli. The cover is a section of a painting by Francesca Macor.
"Potremmo chiederci da dove arriva la sua scrittura, il connubio caotico di prosa e poesia, il versificare sfrenato e senza condizioni, le trame oscure e confuse, il coacervo di immagini che creano dimensioni al di là della stessa surrealtà. Immaginare che vi sia una fonte di pura creatività dentro la poetessa, un nocciolo profondo di assoluta ispirazione magmatica e incontrollabile, una demoniaca possessione della parola poetica. Ma non sarebbe ancora ciò che andiamo cercando, Lital Khaikin infatti non è una poetessa surrealista, non trae la propria forza espressiva dalla dimensione inconscia del proprio sé, da quel magma che è l'Es freudiano, così potente, però così chiuso in una individualità monadica. Nulla è più personale e non condivisibile dello spazio nascosto che giace in fondo alla seconda topica di Freud.
alethe is now available for under 1 Euro (!) on Kipple Officina's website, as well as on Amazon.
The Green Violin is printing once again, and expanding distribution! Copies of all Green Violin publications are always available for mail by request. The Green Violin will be distributing a few publications in Vancouver in early October. Special drop-points are also forthcoming in Atlantic Canada (Moncton, Sackville, Halifax, Saint John, and Fredericton), thanks to an H. de Heutz tour late September, and in Trois-Rivières on October 26.
Tour dates are here, go see the show if you want Green Violin publications!
More copies of the first run of Fiona Sze-Lorrain's not meant as poems and ko ko thett's four poems in Burmese translation will be available through ground and mail distribution later this month (including at the aforementioned Atlantic locations).
New publications are printing now!
A chapbook called Ahn Hak-sŏp #4 by Don Mee Choi is first off the rollers, followed by a broadside titled Prophet Seekers, and other poems by Rethabile Masilo.


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'Black Panther' blows past $500 million at the global box office after one week in US theaters
Published Fri, Feb 23 2018 12:45 PM EST Updated Fri, Feb 23 2018 1:05 PM EST
Tom DiChristopher@tdichristopher
Disney and Marvel's "Black Panther" surpassed $500 million at the global box office one week after debuting in the United States.
High praise from critics and positive word of mouth have helped to sustain the buzz around the first big-budget superhero movie to feature a majority black cast.
"Black Panther" has earned $292 million in North America, the highest one-week North American haul for any Marvel Studios film.
Disney and Marvel Studios' "Black Panther" has hauled in half a billion dollars at the global box office just one week after debuting in U.S. theaters.
The latest estimate from the House of Mouse shows the superhero movie's worldwide ticket sales climbing to $520.1 million through Thursday.
"Black Panther" has now earned $292 million in U.S. theaters, topping the seven-day sales for "Marvel's Avengers" and taking the crown for the best North American opening week for a Marvel Studios film.
In the bigger picture, "Black Panther" can also claim the fourth-best first week at U.S. theaters ever, according to Disney.
"To see these types of revenues generated by a February release is unprecedented, and with China, Japan and Russia yet to open, the $1 billion global mark seems within reach for 'Black Panther,'" said Paul Dergarabedian, comScore senior media analyst.
"Black Panther" has proven its staying power after breaking records during its North American debut last weekend. The film's $40.2 million haul on Monday was the biggest Monday at the U.S. box office ever. Since then, "Black Panther" has posted the best Tuesday, Wednesday and Thursday performance for any movie in Marvel Studios' series of 18 interconnected films.
Audiences have packed multiplexes to experience the first big-budget superhero movie to feature a majority black cast, set its story in an African locale and tackle the legacy of slavery and themes of black identity.
High praise from critics and positive word of mouth have helped to sustain the buzz around "Black Panther," which set social media on fire ahead of its premiere.
The film boasts a 97 percent "fresh" rating on movie review-aggregation website Rotten Tomatoes, the best score for any Marvel Studios movie.
Nearly 90 percent of moviegoers said they would definitely recommend "Black Panther," according to surveys conducted by comScore and Screen Engine.
Heading into the weekend, Box Office Mojo speculates that "Black Panther" could become only the fourth movie in history to earn $100 million in its second weekend in U.S. theaters, before adjusting for inflation. The other films to achieve that feat are "Star Wars: The Force Awakens," "Jurassic World" and "Marvel's Avengers."
Disney projects "Black Panther" could earn $83 million to $95 million this weekend if it follows trends for comparable Marvel Studios films.
Meanwhile, foreign audiences have chipped in $228.1 million since the movie debuted in international markets on Feb. 13, according to Disney. The top overseas markets to date are the United Kingdom, South Korea and Brazil.
"Black Panther" is debuting in the key Russian market this weekend and will premiere next week in Japan, another critical location.
The following weekend, it opens in China, where Marvel Studios movies have recently drummed up more than $100 million in total domestic box office sales.
Comscore Inc
TWDC Enterprises 18 Corp


According to Money, the included schools "deliver a superior education at an affordable price, enabling graduates to avoid heavy debt and succeed in the workplace." Only Princeton University and UC San Diego topped UCI this year. In 2017, the campus placed seventh in the Money rankings.
In indicators of short- and long-term affordability, UCI shined. The campus provides need-based grants to 68 percent of its students, a figure that no other college in Money's top 20 can match. And according to the survey, UCI graduates' median debt load is $17,000, with early-career earnings of $54,900 per year. Money also included newly available data on how many Pell Grant recipients a school graduates, a measure of how well it supports low-income students.
In excess of 11,800 UCI enrollees received Pell Grants in 2016-17 – the most among the Money top 10 and more than the entire Ivy League combined. And the majority of them are first-generation students, for whom a university education provides a means for upward mobility. Almost half of UCI's incoming class of in-state freshmen are first-gen, and the ratio is even higher for California-resident transfer students.
These factors determining the Money rankings help explain why, among UC campuses, UCI had the largest number of in-state freshman applications for the 2018-19 academic year from underrepresented minorities, the most from Chicanos/Latinos and the second-most from African Americans.
And for the second consecutive time, the campus tops The New York Times' College Access Index of U.S. universities based on their commitment to economic diversity, which takes into account the number of low- and middle-income students that a school enrolls and the price it charges them.


One of the easiest waterfalls to visit in Bali is probably the Layana waterfall, located just east of Ubud.
This is a nice 2 step waterfall that you can see without any hiking or entrance fee. It's actually sitting right next to a warung (small food shack) where you can buy food or drinks while hanging out in a hut above the falls.
I expected the owners to charge me a fee for visiting the waterfall, but it's actually free. I didn't try the food at the warung, but I'm sure it's good too.
The waterfall can be seen directly behind Layana Warung, which is located just east of Ubud.
From the restaurant parking, it's just a 30 yard walk down to the waterfall. The track can be a bit muddy and slippery near the bottom, so do watch out for that.
There is no fee for parking or visiting the waterfall. It's free.


Accusations of military interference, encroaching extremism and a series of deadly attacks have cast an alarming shadow over Pakistan's hopes for a rare democratic transition of power in next week's election. Observers have slammed "blatant" attempts to manipulate the ballot, which will see the brother of a recently jailed three-time prime minister face off against a former World Cup-winning cricketer for leadership of the nuclear-armed nation, whose short history is peppered by coups and assassinations. A series of deadly attacks in mid-July has further darkened the mood, denting optimism over hard-won security for the country of 207 million.
Full Article: Military looms large over divisive Pakistan election | GulfNews.com.


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text:
Q: Sqlalchemy filter by date I'm trying to construct a query that filters a list of hotel rates. I only want to  show hotel reservations from today and into the future. The query I built is below but does not filter the results. What am I doing wrong?
hotels = db.session.query(Hotel).\
    join(Location).\
    join(Rate).\
    filter(Location.city == city).\
    filter(Rate.arrive > datetime.utcnow())

For background, my models look like this:
class Location(Base):
    __tablename__ = 'locations'

    id = Column(Integer, primary_key=True)
    city = Column(String(50), nullable=False, unique=True)

    hotels = relationship('Hotel', back_populates='location')

class Hotel(Base):
    __tablename__ = 'hotels'

    id = Column(Integer, primary_key=True)
    name = Column(String(100), nullable=False, unique=True)
    phone_number = Column(String(20))
    parking_fee = Column(String(10))
    location_id = Column(Integer, ForeignKey('locations.id'), nullable=False)

    location = relationship('Location', back_populates='hotels')
    rates = relationship('Rate', back_populates='hotel', order_by='Rate.arrive')

class Rate(Base):
    __tablename__ = 'rates'

    id = Column(Integer, primary_key=True)
    price = Column(Numeric(6, 2))
    arrive = Column(Date, nullable=False)
    link = Column(String(500), nullable=False)
    updated = Column(DateTime, default=datetime.datetime.utcnow, nullable=False)
    hotel_id = Column(Integer, ForeignKey('hotels.id'), nullable=False)

    hotel = relationship('Hotel', back_populates='rates')

Edit:
Here is some sample data:
Date: Friday, Sep 9

Rate: 299.25

Date: Sunday, Sep 11

Rate: 261.75

Date: Monday, Sep 12

Rate: 261.75

Date: Tuesday, Sep 13

Rate: 261.75

Date: Sunday, Sep 18

Removing filter(Rate.arrive > datetime.utcnow()) does not change the data. It is output the same each time I run the query.

A: Option zero is to apply the filter of rates after you loaded the hotels, but this will generate additional queries, and is not desired.
Define filters which are used later on:
city = 'mumbai'
arrive = datetime.date.today()

Option-1: Load Rate of interest in the initial query
query = (
    session.query(Hotel, Rate)  # this query will return pairs (Hotel, Rate)
    .join(Location)
    .join(Rate)
    .filter(Location.city == city)
    .filter(Rate.arrive > arrive)
)

# one could use the results directly as (Hotel, Rate) pairs
# but we can also convert to the format: {hotel: rates}
from collections import defaultdict
hotels_list = defaultdict(list)
for h, r in hotels:
    hotels_list[h].append(r)

# and print:
for hotel, rates in hotels_list.items():
    print('', hotel)
    for rate in rates:
        print('  ', rate)

Option-2: Trick the relationship Hotel.rates
Here we are using contains_eager
hotels = (
    session.query(Hotel)
    .join(Location)
    .join(Rate)
    .options(contains_eager(Hotel.rates))  # this is the key
    .filter(Location.city == city)
    .filter(Rate.arrive > arrive)
)

for hotel in hotels:
    print('', hotel)
    for rate in hotel.rates:  # this now contains only sub-list, so be careful
        print('  ', rate)

redpajama_set_name: RedPajamaStackExchange


Yeah, I'm on some kinda blog roll today. But this is short!!
Vampire Weekend released a new song called 'Horchata'. Now, the drink (which is a type of mexican rice drink w/ spices), is AWESOME.
Though, I used rice milk instead of milk and reduced the sugar to 3/4 cup from 1 cup.
Dude man, I can only describe this as a combination of egg tarts and apples in taste (both of which I love :o).
oh cool, that looks nice!


text:
Award Show Gliz and Glam, Fashion, Trends/News, Tween and Teen Girls
Fashion, Trends/News, Tween and Teen Girls, What's Trending
Categories: Fun, Funny Fashion / January 20, 2020
These outfits are definitely quite a statement piece and probably wouldn't be worn or seen on a day to day basis. However these are just a few of my pick of the funniest and silliest outfits!
Categories: Apps/Games, Fun / January 20, 2020
Kim Kardashian shocked the world again, realising her new app, Kimoji. This app is based on the Emoji characters that Apple had invented for the iPhone, however can now be used on most mobile devices as Emoji's have taken over the world! Kim's new Emoji's range from pictures for her face, her pregnancy, her clothes, her famous selfies, pole dancing and everyone's favourite, Kim's ugly …
Categories: Fashion, Funny Fashion, Kids - Boys, What's Trending / January 20, 2020
This was too cute not to post but it's not every day you see a 3 year old Harry. This Russian boy's name is Michael and has a fast growing Instagram account with currently 116k followers. It is run my his mum to show off his incredible fashion sence and style. To follow Michael and to see his cuteness visit https://www.instagram.com/michaelrangamiz/
Categories: Fashion, Fun, Funny Fashion, Kids - Girls / January 20, 2020
Mother throws outrageous fashion show birthday party for her daughter, dressing her in Chanel, Dior, Louis Vuitton and Prada The mother purchased the extravagant wardrobe from all over the world She rented a hotel foyer and runway to use in Taiyuan, Shanxi province The mother spent over 1 million yuan – or $AUD204,177 (US $157,000) – on the lavish outfits The wardrobe features Louis Vuitton, Dior, Burberry, …
The Fault in Our Stars by John Green (Goodreads Author) Despite the tumor-shrinking medical miracle that has bought her a few years, Hazel has never been anything but terminal, her final chapter inscribed upon diagnosis. But when a gorgeous plot twist named Augustus Waters suddenly appears at Cancer Kid Support Group, Hazel's story is about to be completely rewritten. Insightful, bold, irreverent, and raw, The Fault in Our …
Categories: Fun, Music / January 20, 2020
The old Hilary is back! New show, new song, new hair — this is the season of Hilary Duff and everybody else is just living in it and/or complaining about how it's still too cold outside. This latest single is called "Sparks," and while we loved Hilary's super chill single "Chasing The Sun" she dropped last year, "Sparks" super poppy upbeat feel is a refreshing …
Pop star Taylor Swift and British soul singer Sam Smith, who were among the top-selling musical acts in the US last year, led the nominations for the 2015 Billboard Music Awards finalists. Taylor Swift earned four nominations for the 2015 Billboard Awards, including nods for top artist, best album for her '1989,' and best female artist. Swift will go head to head with British soul …


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Q: JPA Adding Logic to Removing an Entity I am somewhat new to using JPA -- I'll put that out there right off the bat. I'm getting more familiar with it, but there are big holes in my knowledge right now.
I am working on an application that uses JPA, and deletes entities using the EntityManager.remove(Object entity) function. However, the application also links into a third-party application, and I would like to add logic that gets executed whenever a certain type of Entity is removed from the persistence layer.
My question is this. Is there a way to add logic to the EntityManager.remove(Object entity) function on a Entity class level, such that every time that type of entity is deleted the extra logic is executed?
Thanks much.

A: Entity class may have methods annotated with @PreRemove or @PostRemove.

A: If you are using Eclipselink, it has a much more fine grained native event system via the DescriptorEventListener interface.


They were very friendly and understanding. Had a meeting get bumped to later afternoon due to weather and they made accommodations for us to stay and not kick us out. Will definately make this our place for KC!!!
The room was very nice and comfortable. I was solo, but the layout would have afforded privacy with a small wall dividing 'living' space from bedroom. The breakfast was standard, eggs, bacon, cereals, yogurt, but it was good. My only disappointment was in the pool. It was very small - too small to actually swim- and cloudy.
The suite was comfortable for our family of 5. Staff was friendly. Lots of movie channels. In door pool was just so so. Way over chlorinated... the water was foggy and the smell was very strong. Water pressure in the shower was terrible, but overall we enjoyed our stay and would stay there again.
Although I prepaid for the room for December 29th and 30th, at checkin they charged me $180 plus the $40 incidental fee. As of January 4th, they still have not refunded those fees!!!!
The staff was very friendly and the hotel was very clean. The problem was that you can hear everything around you. We were woke up every morning by the people showering next door. We could hear every time they flushed the toilet, turned on the water or the hairdryer. It's sad that this is not in anyone's control, but unfortunately we would not stay again.


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Woolpert has been hired by Pinellas County to implement Cityworks software and develop a comprehensive enterprise asset management (EAM) program.
The $6.5 million, multiyear contract includes the development of an asset management program, software installation and configuration, enterprise system integrations and deployment to all divisions that manage county infrastructure assets.
The asset management program will align with internationally recognized standards established by The Institute of Asset Management (IAM) and documented in ISO 55000.
"We'll be building an asset management framework and developing content to help the county make the best long-term decisions when it comes to repairing or replacing its $4 billion in assets," said Program Director Steve Schwabe, one of Woolpert's 12 IAM-certified professionals. "Not every asset needs to be treated equally, and this program will allow the county to prioritize assets in terms of importance to their operations. Then they can optimize their preventive maintenance programs and reactive maintenance procedures such that critical assets receive the attention they require, and time and money are not overextended to an asset with a smaller value or risk of failure."
Jim Fletcher, Pinellas County's EAM program sponsor, said the economy and the aging infrastructure of the county factored into the decision to adopt this program.
"We needed to take a hard look at the way we're doing business and specifically our asset and infrastructure management plan, which was not sustainable," Fletcher said.
He added that the county has taken proactive steps to address the need.
"This is a global approach, and our business case clearly supported EAM implementation," he said. "The rest of the world believes that the ISO 55000 Asset Management Standards are the bible for effective and responsible asset management."
Schwabe said Pinellas County is extremely well-run and responsible, and lauded the municipality for professionally managing its multibillion-dollar portfolio.
"They're a very sophisticated and forward-thinking group, and they've spent nearly three years figuring out what this project should be," Schwabe said. "It's been refreshing to work with an organization that understands the difference between an asset management software and an asset management program. Pinellas is going about things the right way by developing a program within which their asset management tools will be applied."
Dragonfly Consultants is part of the Woolpert team, helping Pinellas County employees prepare and adapt to change as a result of a large-scale system implementation.
"In order to get the full benefits of this system, the county understands the culture will need to shift. They are committed to understanding the impact and implications this will have on how people lead, manage and work every day," said Adrienne Seal, managing partner and coach at Dragonfly Consultants. "We're helping Pinellas understand how being proactive about change and using an inclusive change approach will make these implementations more successful and sustainable."
Steven Alston is the county's EAM change management lead.
"Some change you're prepared for, and some change you have to deal with as it occurs," Alston said. "At end of the day, it's all about supporting these individuals and getting them and the county where we need to be by ensuring alignment of our people, work process and technology."
The implementation is scheduled to get underway in October.
About Woolpert
Woolpert is a national architecture, engineering and geospatial (AEG) firm that delivers value to clients by strategically blending engineering excellence with leading-edge technology and geospatial applications. With a dynamic R&D department, Woolpert works with inventive business partners like Google; operates a fleet of planes, sensors and unmanned aerial systems (UAS); and continually pushes industry boundaries by working with advanced water technologies, asset management, Building Information Modeling (BIM) and sustainable design. Woolpert's mission is to help its clients progress—and become more progressive. For over 100 years and with 23 offices across the United States, Woolpert serves the needs of federal, state and local governments; private and public companies and universities; energy and transportation departments; and the United States Armed Forces. The firm currently is doing business in all 50 states and in five foreign countries. For more information, visit woolpert.com or call 937-531-1258.
About Dragonfly ConsultantsDragonfly Consultants takes a refreshing approach to Organizational Culture, Strategic Change, Coaching, and Leadership. We offer a distinct leadership development program aimed at helping organizations create inclusive cultures. As leaders, we have over 50 years of experience across numerous industries from start-up to global Fortune 500 companies. We offer a range of services directed at both transformational and operational change, including executive coaching, leadership skills coaching, culture assessment, organizational design and development. For more information, visit dragonflyconsultants.net.
via prweb
Tags: asset management, woolpert


Last time I was at the Kingdom Hall they were praising themselves about all the growth in members they have been having. Is this "growth" they are having statistically accurate?or are a lot leaving?
If I were you I'd check the most recent yearbook.
The growth of Jws has definitely peaked in the developed world. Look to the BRIC countries that's where growth will be.
Where's InsideTheKH when you need him to confirm that growth is in fact massive?
I suspect that even if Botchtower tracks people who leave, I am not sure they'd publish those facts. It probably doesn't look good.
With a large majority of the industrialized world's people aging, there is quite a number who will become too old to witness and will die off in the next 20 years.
My Father is one of these people. I have no idea what his official status is as a JW. I suspect it is 'inactive'. I guarantee they've removed him as a Ministerial Servant. He no longer has the ability to witness. Dementia has a way of doing that to a person.
I live in a medium-sized mid-western town with a handful of English congregations. In the last few years, I have observed zero growth and probably decline. I can't even remember the last convert from the field. I know that is anecdotal, but I think the situation is so common that the anecdote can be taken as a general indicator.
The excitement is gone. Nobody talks about the nearness of the end the way JWs used to. There is no discussion of prophecy the way there used to be. JWdom is no longer the bold, confident, in-your-face entity it once was. It is, as has been said on this site many times, dumbed down. It's corny and shallow.
The org is no longer attracting normal individuals or families with decent knowledge and intelligence. If it is gaining members, it's either those with previously existing JW connections, those in under-educated areas, or those who are naive.
A friend of mine has been going to the same hall for 25 years. Not one new convert in all that time.
JW`s are Breeding More Members,than Converting more Members..
..We Made a "NEW" Jehovah`s Witness!................."New Jehovah`s Witness" Warehouse..
I encountered a jw from the last congregation I attended. She said they had so many new ones...so I asked.
Are they newly baptized jws or are they already jws that changed to that congregation?
That means that somewhere a congregation(s) went down 6 jws. Do have some unbaptized adult jws coming to the meetings, other than minor children of jws?
Then she scurried off. I hated this statement when I was a jw.


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From the classroom to the campus
Helping students in Canada transition from school to university
Callum was a regular at church, even through his teenage years. He played the drums in the church youth band once a month, and in his final year of high school he was one of the leaders at the Friday night youth club. The younger boys looked up to him. Christian family, summer camps, youth group — he would be fine at university, no question.
But Callum wasn't fine at university. He never really settled into a church — it was a bit of a walk from where he was living, and the morning service started at 9.30am (much too early after a night-out). He went along once or twice to the student fellowship group in the first semester, but they kept going on about evangelism and it made him feel uncomfortable. He never went totally off the rails, he just slowly drifted away. The change was so gradual, he hardly noticed it. Finals, football and a new girlfriend took up all his time. Four years later when he graduated and landed a good job in the city, it didn't even cross his mind to find a church. He no longer called himself a Christian anyway.
The alarming reality
Callum's story is based on the story of thousands of young people in Canada.
A survey carried out in 2011 showed that two out of three young adults (aged 18–34) who had been raised in the church in Canada, were no longer attending. The survey results shook the Christian community across the country. The drop-out rate was alarmingly high. Since then, InterVarsity Canada have been taking action to try to reverse the trend: three years ago they recruited staff to re-pioneer high schools work in a couple of its big cities. Their focus would be on getting the students into the Bible, encouraging them to think missionally and helping them to transition well into university.
by Justin Eisner on Unsplash
It was not going to be a quick or easy task. Once healthy and thriving, high schools ministry in Canada had declined in the 1990s and early 2000s, as schools became less open and various staff members left. They needed to start again from scratch.
In Toronto, Inter-Varsity staff spent a few years concentrating on building relationships and trust with local pastors and headteachers. When doors started to open up, they found that the familiar campus ministry model would need to be adapted for the high school context. For one thing, the students' lunch breaks were short. They'd only have about 15 minutes for a Bible study, so the passages would have to be chosen carefully — a short parable or just a few verses. The staff were keen to equip the students with skills to handle the Bible faithfully on their own. So they taught the students how to ask simple questions of the passage: What could they observe? What did it mean? How could they apply it to their own lives? These were tools they could use in their personal Bible study times or in leading groups in the future.
42-week mission trip
Helping high school students develop a missional mindset was key. But how? Toronto staff had an idea. They knew that most students would be familiar with the concept of a short-term mission trip — one or two weeks in the summer serving overseas or downtown in the city. Staff decided to capitalise on that and launched the idea of a 42-week mission trip. The school campus was their mission field for every week they were at school. They encouraged the young people to team up, to pray, to survey and plan, to try something, and then to debrief together — just as they would do on a short-term mission trip. They asked the students to consider where they were already involved in school life — a sports team, a jazz band, a social action club — and then encouraged them to live and think missionally in those communities.
Slowly, the students started to get on board. The weekly lunchtime slots became evangelistic opportunities, while planning and prayer moved to the mornings or after school. 60–80 students came along to Christmas and Easter events, organised and led by the students themselves. One group of guys ran a 'pop and prayer' event, where they handed out free pop to teachers and students, and then offered to pray for them. One girl finished school and then decided to take a year out serving Inter-Varsity school Christian fellowships — she started leading a Bible study for Muslim students.
Developing Bible-based, mission-minded high school students was one thing; but would they stick at it when they transitioned to university?
by Bewakoof.com Official on Unsplash
Transition 101
To help give the high school students a fighting chance of transitioning well into university life, a new initiative was launched in Toronto this year: Transition 101. Different youth ministries teamed up to host an event at which Christian university students would come and meet high school students. There were seminars on a range of topics, including how to survive at university, apologetics, spiritual disciplines and mental health.
It was also an opportunity for the high schoolers to make connections with older students already there, students who could encourage them to keep the missional mindset as they started at university in a few months' time. Research carried out in 2018 found that young adults going on to further education are four times more likely to connect with a Christian campus group or chaplaincy if someone from their home church tries to make a connection for them. Initiatives like Transition 101 will, God-willing, help reduce the drop-out rate.
by Timothy Choy on Unsplash
Hitting the ground running
There are already stories of students transitioning well. Noah is one of those. He's just started university in Canada, having been involved in InterVarsity ministry in high school. He writes about his experience as a freshman so far:
"Having been part of a Christian group in high school, I was able to learn about on-campus ministry opportunities before getting to university. That made it easier to get involved once university started. I knew that I wanted my faith to continue to grow and my relationship with Jesus to deepen. Looking back on my first month of university, my main encouragement for future freshmen would be to get involved with on-campus ministry and find a church to call home as soon as possible, before the semester gets into full swing."
InterVarsity Canada staff are praying that there will be more stories like Noah's, of students arriving at university ready to hit the ground running. In such a vast country, staff-workers are spread thinly. If student ministry is going to flourish it's essential to get Christian students on board as early as possible with the vision of reaching out on campus. Similarly, it's important to invest in graduates as they transition into the working world, so that they, too, can hit the ground running in their workplaces, envisioned to live and speak for Jesus.
InterVarsity Canada President Nigel Pollock reflected:
"We are increasingly seeing that discipleship is a process from early teens to late 20s. Student ministry — and in particular being involved in leadership in a campus group — is a really significant opportunity for students to grow in a different environment which complements and adds to their local church experience. Mentoring students through the key transitions from high school to university and from university into work makes an enormous difference to the effectiveness of student ministry and the impact of the gospel in people's lives."
Only with continued investment in these critical transition stages might the trends be reversed. Pray with us that this might be so, in this generation.
The full survey reports can be found here:
https://p2c.com/wp-content/themes/avada-corp/files/Renegotiating-Faith-Report.pdf
http://hemorrhagingfaith.com/
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The 5,000-square-foot facility is the largest Express Category Pizza Inn and hosts another restaurant, SuKasa Grill & Bar. It seats 96 guests and features a pick-up window and a room for private parties and meetings.
Pizza Inn Express recently reopened its doors to Hebbronville in a brand new facility located at 204 West Viggie St., next to State Highway 359.
On Wednesday, Feb. 13, Pizza Inn will celebrate its grand opening with raffle drawings and door prizes. The 5,000-square-foot facility is the largest Express Category Pizza Inn and hosts another restaurant, SuKasa Grill & Bar. It seats 96 guests and features a pick-up window and a room for private parties and meetings.
"We're so excited to be open again in Hebbronville," said Franchisee Dave Gonzalez. "Our first location was a huge success, so we can't wait to show the community a larger location with room to sit, play games and enjoy time with family and friends."
Gonzalez has been a part of the Pizza Inn family since 2014. Over the last four years, the Hebbronville PIE has given back to the local church and various fundraisers in the community. The restaurant's biggest event is supporting local kids in the Jim Hogg County Fair. Over $5,000 a year is donated to these organizations.
The Hebbronville Pizza Inn store hours will be Sunday through Thursday 10 a.m. to 10 p.m. and Friday and Saturday 10 a.m. to 11 p.m.
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If you are a member of Pizza Inn you may be interested in learning how to optimize your content on our network.


Annotation: STATES' USE OF SECURE DETENTION CENTERS AND JAILS FOR JUVENILE OFFENDERS DURING THE MID-1970'S IS DESCRIBED AND DIFFERENCES AMONG STATES ARE EXPLAINED.
Abstract: STATE PLANS AND STATES' MONITORING REPORTS ON STATUS OFFENDER DEINSTITUTIONALIZATION ARE AMONG REPORT DATA SOURCES. OTHER SOURCES INCLUDE PUBLISHED AND UNPUBLISHED STUDIES AND THE FBI UNIFORM CRIME REPORTS. ANALYSIS OF THE DATA INDICATES THAT DURING THE MID-1970'S ABOUT 520,000 JUVENILES WERE BEING ADMITTED ANNUALLY TO DETENTION CENTERS IN THE U.S., WHILE ABOUT 50 PERCENT OF ALL ADMISSIONS OCCURRED IN CALIFORNIA, OHIO, TEXAS, WASHINGTON, AND FLORIDA. CALIFORNIA LED THE NATION WITH A TOTAL OF 139,423 ADMISSIONS IN 1975. APPROXIMATELY 120,000 JUVENILES WERE DETAINED ANNUALLY IN ADULT JAILS IN THE MID-1970'S, WHILE OVER 50 PERCENT OF THESE ADMISSIONS OCCURRED IN IDAHO, ILLINOIS, KENTUCKY, MINNESOTA, NEW MEXICO, OHIO, OREGON, TEXAS, VIRGINIA, AND WISCONSIN. ALTHOUGH NO CLEAR REGIONAL DIFFERENCES ARE APPARENT, SEVERAL MOUNTAIN AND WESTERN STATES RELIED MORE ON ADULT JAIL DETENTIONS FOR JUVENILES THAN DID EASTERN, PARTICULARLY NORTHEASTERN, STATES. THE COMBINED RATES OF ADMISSION TO BOTH CENTERS AND JAILS IN EACH STATE RANGED FROM 117 TO 4,734 PER 100,000 JUVENILES; THE WEST HAD SUBSTANTIALLY HIGHER COMBINED RATES. STATUS OFFENDERS CONSTITUTED 26 PERCENT OF ALL ADMISSIONS. ANALYSIS DID INDICATE SOME FACTORS AFFECTING STATE RATES OF ADMISSION. FOR EXAMPLE, DEGREE OF URBANIZATION IS POSITIVELY RELATED TO DETENTION CENTER RATES AND NEGATIVELY RELATED TO JAIL DETENTION. RATES OF REFERRAL TO COURT INTAKE ARE POSITIVELY ASSOCIATED WITH RATES OF DETENTION CENTER ADMISSION, AND JUVENILE ARREST RATES ARE ASSOCIATED WITH JAIL ADMISSION RATES. OVERALL, THE ANALYSIS POINTS TO CONSIDERABLE VARIATION IN STATES' USE OF DETENTION, A VARIATION THAT MUST BE CONTROLLED. REMEDIAL APPROACHES ARE SUGGESTED. FOR ONE, DECISIONMAKING FOR INTAKE AND REFERRAL MUST BE DOCUMENTED WITH WRITTEN CRITERIA AND WRITTEN AGREEMENTS BY ADMINISTRATIVE OFFICIALS. IN ADDITION, AN INFORMATION SYSTEM SHOULD BE CREATED TO MAINTAIN DATA ON JUVENILE PLACEMENT. FINALLY, POLICE DIVERSION PROGRAMS SHOULD BE CONSIDERED FOR REDUCING JUVENILE ADMISSIONS TO JAIL, AND ALTERNATIVES TO DETENTION AND COURT DIVERSION PROGRAMS SHOULD BE CONSIDERED FOR REDUCING DETENTION CENTER ADMISSIONS. FOOTNOTES, TABLES, MAPS, DATA SOURCES, AND 24 REFERENCES ARE INCLUDED.