Researchers Say Gene Therapy Increased Cancer Risk New research shows that an effort to cure X-SCID (also known as the "bubble boy disease") using gene therapy may have had an unintended consequence -- causing cancer in people who tested the therapy.
From NPR News in New York, this is TALK OF THE NATION: SCIENCE FRIDAY. I'm Ira Flatow. Think human evolution is a thing of the past? Well, researchers studying our genomes say we're still evolving, with many changes to our genes within the last 10,000 years, really just a recent blip in our evolutionary history. This hour we'll talk with New York Times science reporter Nicholas Wade about how DNA analysis is rewriting our recent and ancient history.
Plus, we'll talk about a new study that explains how a successful gene therapy can cause cancer. And as global warming heats up the ocean, more and more coral reefs are dying, but scientists have found that one species of coral survives deadly bleaching by bingeing. It's all coming up after this break. Stay with us.
This is TALK OF THE NATION: SCIENCE FRIDAY. I'm Ira Flatow. In June of 2002, researchers announced the results of a gene therapy trial for children with severe combined immunodeficiency, commonly called, The Bubble Boy disease. That's a fatal genetic disease that leaves its victims without an immune system, but there was hope.
Using gene therapy, the researchers were able to insert a healthy copy of the faulty gene into the sick children, and many of the kids went on to develop an immune system and were cured of the disease. This trial was considered proof that gene therapy worked, but then three years later came a surprising consequence.
Researchers reported that three of the boys treated with the gene therapy went on to develop cancer; leukemia. And now another team of scientists thinks they know how those boys got cancer. They report their findings in this week's issue of the journal Nature, and the lead author joins us today to talk about their study.
If you'd like to talk about it, our number is 1-800-989-8255, 1-800-989-TALK. Inder Verma is the American Cancer Society Professor of Molecular Biology, professor in the laboratory of genetics at the Salk Institute for Biological Studies in La Jolla, California. He joins me today by phone from New York City. Welcome back to the program, Doctor Verma.
Dr. INDER VERMA (American Cancer Society): Thank you, Ira.
FLATOW: Now let's talk a bit about the background here of this gene therapy to treat this disease. One gene was inserted in the children? Is that what happened?
Dr. VERMA: Right. I think the way you described it is exactly right. They took, what these children were suffering from the deficiency of one gene which made a protein called gamma C chain. That protein is necessary for formation of the immune cells--B cells and T cells--to fight infection. Without that gene product, the children have no ability to fight infection, and that's why you said David, the bubble boy, had to live all his life in a bubble.
Dr. VERMA: So these people, the, to the French group, take the bone marrow of these children, who would have surely otherwise not survived unless they got a bone marrow transplantation, took their bone marrow, introduced into them the gamma-C chain using a viral vector system called retroviruses, and all these children showed a remarkable improvement of their immune function as judged by their ability to make antibodies, as judged by their ability to fight infection. They went to school. They behaved normal.
And as you said, three years later came the development of leukemia, and the argument was made that why--what happened is, that when the virus gets into a cell, it really cannot be controlled where it goes. It may have gone in the vicinity of another gene--in this case referred to LMO2--which normally is not making any protein, but when it does inappropriately, it can cause leukemia. So the argument was made that the virus might have inserted itself next to this gene, thereby activating it when it should not have been activated, and that results in T-cell lymphomas.
FLATOW: So, based on that data, we said we will perform the same identical experiment in mouse to ask the question, can we reproduce the phenomena that happened in human and could we learn from this? So we found a mouse which is exactly the duplicate of the same disease as the gamma C chain deficiency; made exactly the same experiment, except we used a different vector--a same family of vector but slightly different--and did the same experiment; and were surprised on two counts.
First, the experiment was done the following: one, where we took just the gamma C chain alone; second, where we just took the LMO2, the gene which is the offending gene of causing the disease; third, we combined the gamma C and the LMO2 together in one vector, so we give it the best chance to make cancer; and finally, a control which had a nonspecific gene, has no business to cause cancer.
So what we found that the control, 100 percent of the animals were fine. In those which had the LMO2, 40 percent of the animals came down with leukemia, as we expected. But what surprised us the most was that where gamma C chain alone was used, 33 percent of those animals also came down with the same kind of a tumor that was witnessed in these children, except it took them six months before we could observe them and some came as late as 10 months.
So in children, it was also after three months, uh, three years. Now it's difficult to compare the life of a mouse and that of a human, but it pointed to the fact that the gene product that was being used to correct the defect, had also the ability to cause cancer by itself. And therefore, one has to be, uh, rethink the idea of using genes like this, which have the ability to cause cancer. Possibly because, this gene is just not for one gene alone. There are a number of other genes which requires the same gamma-C chain to function. So we don't understand how that works.
FLATOW: Yeah. So you don't understand why this gene could cause cancer, do you?
FLATOW: Or else you would not have put it in in the first place.
Dr. VERMA: So, what happens is that, this gene is a third leg of a receptor which requires this. In other words, there are many receptors which are needed to make T cell, B cells. They have two components, but they need the third component which is called the gamma C chain. But it turns out there are six other receptors which also need the same gamma C chain.
So when we put gamma C chain in cells--in this case, all of them got the same gamma C chain--and therefore, there was a dis-regulation. So we don't know why and how, when multiple components which were missing this gene also got it, how they might have behaved. And that's something which we'll follow on. But the surprise still remains that the gamma-C chain alone has the ability to cause about the same number of tumors as have been observed in the case of human.
Dr. VERMA: I think it certainly should make people think about it because the first question one will ask is could it be that the method we used made more protein than normally, and it's therefore not natural? Well, that is a reasonable argument, but you can't really say that because we can't control in the human gene therapy trials how much protein will be made. We can't control how much virus will go in.
We cannot control how much virus will integrate, and therefore, there is a concern now--that since we can't control that, and since the protein has the ability, whether we make too much or too little--it certainly has the potential to cause the disease. And therefore, it requires rethinking how we might want to do it.
FLATOW: Mm hmm. Do you think that this rethinking in these risks are true not only for this gene but for others like it? Or do you think that it's likely to happen with all forms of gene therapy?
Dr. VERMA: No, no, no, because, definitely, not. Because there's another kind of a SCID, the same bubble boy, where the deficiency is a gene called a adenosine deaminase gene, which is a known enzyme. There you just put the enzyme back, and that enzyme can do the function. So there we don't think the same function will happen. Now there, the virus that can integrate in the vicinity of an offending gene can still happen, but it can't be due to the gene product itself. It may be due to other reasons but not the gene product, so it's different than the gamma C chain.
FLATOW: What has happened since with the other kids who did not come down with the cancer?
Dr. VERMA: Well, first of all, it's a matter, it's a--I definitely hope that none of them will come down.
Dr. VERMA: It's a perfectly reasonable to assume, and maybe they made small amounts of it. Maybe they made the correct amount of it that fit perfectly, and I hope that that is the case. However, we didn't see this tumor till six to 10 months, so it's a little be more long-lasting. We need to wait a little bit longer to be absolutely certain. But it is quite possible that these kids, and I hope, are going to be ok.
FLATOW: Are they kids who have the leukemia? Are they under treatment and in remission?
Dr. VERMA: I don't totally know that. I know one case they did a new bone marrow transplant. And another case the kid, I think, is responding to that. And the third kid, I don't know what is happening. But I know one who's responding, and one got a marrow transplant.
FLATOW: Is it not possible to think, and I'm thinking as a parent, or someone who takes care of kids, that if your child had this disease you might want to take that risk?
Dr. VERMA: You know, it's very hard, because when you're a parent whether that child, and when the time comes, I don't know. But I personally, would think, yes, it's worth taking the risk.
FLATOW: Yeah. Taking the risk and trading, possibly trading one illness for another. And one--and at leukemia, you know, we don't want it to happen, but might be curable, whereas the baby-bubble-boy disease may not.
Dr. VERMA: Yeah. The only other thing one could argue in that case is, and that's been done, that if you have a matching bone marrow, that may be the easier way to do it, because bone marrow transplantations are very successful, and that that might allow these children to have a normal. But finding a successful matching bone marrow is also not a trivial undertaking.
FLATOW: Yeah. So your case doesn't make, your study doesn't make a case for halting all gene therapy trials.
Dr. VERMA: No. No. Definitely not, definitely not. The only place where we think it is worth considering rethinking is in the gamma C chain, because there's an evidence of it. But it certainly does not say, and I hope that is not the impression, that they stop gene therapy, because those other things. Here is the product itself is toxic, not the methods, the product.
FLATOW: Yeah. Because we haven't seen a whole lot of successes in gene therapy yet.
Dr. VERMA: Well, I understand there's a group in Italy, now, they use ADA gene, and they have a successful reconstitution of the immune system, also. So that's another example.
FLATOW: Oh, there's something new, then?
Dr. VERMA: Yeah. That is the thing(ph) that has been going on in Italy in San Rafaela(ph) Hospital, and under the direction of Doctor Claudio Bodinio(ph). And that's--I understand again, I would haven't seen that later(ph) data, supposed to be very encouraging results.
FLATOW: So there may be an alternative developing.
Dr. VERMA: Yeah. So there's, it's a different kind of the same technology, but a different gene product.
FLATOW: I see. Well, we can always be hopeful, that something new will happen.
Ms. VERMA: Yeah. I still am, otherwise I wouldn't be working on it.
FLATOW: All right, and, as I say, we're all waiting for some good news in gene therapy.
Dr. VERMA: And I hope you will have soon enough, and me too. You're in the same (inaudible) that I am.
FLATOW: All right. I want to thank you very much for taking time to talk to us, and good luck to you. And we'll be back talking with you with good news, sometime, hopefully.
Dr. VERMA: Thank you very much. Shall I get off the phone now?
FLATOW: Yes you can. Have a good weekend.
The truth comes out in Science Friday. That's Inder Verma is the American Cancer Society professor of molecular biology, professor in the laboratory of genetics at the Salk Institute for Biological Studies in La Jolla, California. And he was joining--on the phone from New York. And we like to thank everybody who takes time out on a late Friday afternoon to be with us and talk to us.
We're going to take a break and we're going to come and we're going to switch gears and talk about the world's coral reefs are dying. And we'll talk about one reef, one kind of coral in particular, that has found a way around this bleaching. So stay with us. We'll be right back.
FLATOW: I'm Ira Flatow with this is TALK OF THE NATION - Science Friday, from NPR News.


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Jeffrey Wayne Frazier
Jeffrey Wayne Frazier, 66, of Statesville, N.C., passed away peacefully in his home on Thursday March 18, 2021, with his children by his side.
Jeff was born October 3, 1954, in Iredell County and was the son of the late Paul Stephen Frazier and Frances Lundy Frazier. He was a graduate of Statesville High School and retired from Iredell County as the director of Facility Services as well as West Iredell Fire Department, where he served for decades. He was a proud member of The Rock Church and was always helping others. He was a one-of-a-kind man who loved his family, God, working, camping, and riding his RZRS (side by sides)
In addition to his parents, Jeff was also preceded in death by his son, Adam Frazier; niece Katie Sigmon; and brother-in-law, Jack Sigmon.
Jeff is survived by one son, Josh Frazier of Statesville; one daughter, Abby Frazier of Statesville; four grandchildren, Bryson Caldwell, Adriana and Emma Smith, and Lucas Frazier; two sisters, Judy Howard (Ronnie) of Union Grove, and Elaine Sigmon of Statesville; two nephews, Travis Howard (Emily), and Kyle Howard (Melia); one niece, Emmylou Madison (Ben); and five great nieces and nephews, Avery, Brennan, and Smith Howard and Luna and Juniper Madison.
A memorial service for close friends and family will be held on Saturday March 27, 2021, at 1 p.m. at The Rock Church with Pastor Mike Pharr officiating, followed by a receiving of friends at 2:00pm.
In lieu of flowers, memorials can be made to The Rock Church, 1737 Suite D Wilkesboro Highway, Statesville, NC 28677 and Hospice of Iredell County, 2347 Simonton Road, Statesville, NC 28625.
Online condolences can be made to the family at www.troutmanfuneralhome.com.
Troutman Funeral Home is serving the family.
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Allen Bowen says:
To the family of Mr. Frazier
Numbers 6:24-26
"May The LORD bless you and keep you; 25 May the LORD make his face shine on you and be gracious to you; 26 May the LORD turn his face toward you and give you peace." '
Allen Bowen

redpajama_set_name: RedPajamaCommonCrawl


[Syrphidae] Syrphid Collector of the Year!
What a wonderful idea: The flower fly of the year!
localities. The syrphid collector of the year!
Tropidia scita would be of great help to us.
Pedersen in Denmark and Claussen in northern Germany.
contributes the most (species, not specimens) to us.
Maryland.  Your contributions will be promptly acknowledged, etc.
nothing is known about the larval biology of this distinct species.
decaying potatoes that are lying in water.


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All kinds of precious stones for trade
There are many types of gemstones, each of which is known for its specific characteristics, in the following we will discuss the features and properties of each.
Emerald gemstone: The original emerald has a pure color and does not show a colored flash. However, natural emerald reflects a few flashes called fire, these stones are weak against heat and may crack due to heat. . Imitation emeralds, like the rainbow, show different colors and are recognizable. These stones are used to treat stomach disease and epilepsy. Emerald decoction is also used to treat cancer.
High Jade Emerald: High jade is another type of emerald stone that has a high color variety and its price is very high. This stone has anti-stress and anti-anxiety properties and is also used in seizures.
Turquoise: Turquoise is naturally formed in the mountains and rocks on the basis of water, and aluminum and copper are also involved in its formation. Due to the presence of water, turquoise stone has pores, this stone is widely used in making jewelry. Among the medicinal properties of turquoise, we can mention the improvement of heart and eye function.
Diamond: Diamond is one of the rarest gemstones in the world. These gemstones are clear and colorless and are found in nature in different colors, but in general they are not different in structure, red diamonds are found only in South Africa and Western Australia. Pink diamond is more rare and shows the highest clarity and quality. Diamond has many healing properties and prevents the formation of kidney stones, bladder and gallbladder, and is also effective in improving the function of the brain, cerebellum and muscular system.
Opal and ruby, famous gemstones
Sapphire: Sapphire is mined in various forms such as red, yellow, sapphire and green. Sapphire is a precious stone that is used in making rings.
Ruby: Ruby has a special structure that can be scratched by being placed next to other stones, impure ruby with fine black beads is the original gem and is very rare without impurities and high quality. These stones are used to treat heart disease, strengthen the kidneys and improve the function of the circulatory system.
Opal Gemstone: Opal consists of repeated chalcedony and quartz strips. These minerals play an important role in the formation of metal oxides in these rocks and cause the opal rock to appear in different colors in nature. The most famous type of this stone is Yemeni or Yemeni agate, which is one of the most expensive agates. One of the characteristics of the original agate stone is that it does not scratch the glass and does not burn with fire. This stone is used to treat problems with concentration and memory and to regulate blood circulation.
In which regions of Iran are there different types of precious stones for trade?
In Iran, most precious stones are formed in the form of gravel and sedimentary materials in the riverbed, Ilam and Ceylon stones are formed in this way. Some stones, like the original pearl of an animal, are made from oysters and amber is made from the gum of trees. Important areas of gemstone formation are Neishabour, Kerman, Azarshahr, Ilam, Qom, Khorasan, Hamedan, Isfahan, Kurdistan and Semnan.
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Banking-Related Phishing Scams on the Rise Again in Singapore; Police Flag at Least 28 Cases Since May
By Staff Reporter, 05 June, 2022
BANKING-related phishing scams are on the rise again, with bank staff impersonation calls or unsolicited SMSes claiming at least 28 victims who collectively lost S$114,000 since the start of May, the Singapore Police Force (SPF) said in a statement on Sunday (Jun 5).
The update came just as the Monetary Authority of Singapore (MAS) and Association of Banks in Singapore (ABS) last Thursday announced more measures for banks to safeguard their customers from digital banking scams, on top of those relayed on Jan 19.
The latest measures, which are slated to take full effect by Oct 31, would require banks to roll out additional customer confirmations to process significant changes to customer accounts and other high-risk transactions identified through fraud surveillance. Default transaction limit for online funds transfers would also have to be set at S$5,000 or lower.
Banks are also expected to provide an emergency self-service "kill switch" for customers to suspend their accounts quickly if they suspect their bank accounts have been compromised.
They should also facilitate rapid account freezing and fund recovery operations by co-locating bank staff at the SPF Anti-Scam Centre.
The January round of measures had banks removing clickable links in emails or SMSes sent to retail customers, and were implemented after at least 469 OCBC customers fell prey to such scams and lost a total of at least S$8.5 million in the month prior.
On Sunday, the police noted 2 variants to the latest trend of phishing scams.
In the first variant, callers would impersonate bank employees to ask for victims' personal details such as Internet banking username and password.
This would be done under the pretext that the bank required their personal information to verify transactions performed in the victims' account, or that the victim was under investigation for transferring large sums of money to another bank.
The callers would succeed after asking the victims to convey the one-time passwords (OTPs) that would be sent to the victims' mobile phones upon login.
In the second variant, the victims would receive unsolicited text messages claiming that their debit or credit card had been blocked due to unusual activities, or that their bank account had been frozen because the "bank account was unusual".
The police said the SMSes would direct victims to sign in via an embedded link to verify their identity. After clicking through, the victim would be sent to a spoofed Internet banking log-in page, where the victim would key in his online banking username and password.
Later, the victim would be redirected to another webpage requesting them to key in the OTPs that they would have received on their mobile phones.
Victims of both variants will only discover that they have been scammed when they were notified of unauthorised transactions made on their bank accounts, the police said.
Business Times/Singapore
Phishing Attack
Albanian Government Websites and Services Forced to Shut Following Cyberattack
Hackers Leaked Two Billion Usernames and Passwords in 2021
Several South African Government Websites Crash


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Cleaning to Improve Health in Schools
According to the Centers for Disease Control, nearly 60 million school days are lost each year due to colds and the flu. In addition, asthma tends to be a big concern in schools; with close to 10% of students impacted to some degree. The American Lung Association estimates that children miss more than 14 million school days per year due to asthma. For many schools, student sick-days equal lost funding. With most schools all across the country now back in session, maintaining a healthy, clean environment for students and educators is crucial.
Cleaning to improve health in schools means using tools and procedures most likely to effectively remove germs from the educational environment and safeguard indoor air quality. This may involve using microfiber tools and backpack vacuums; using color-coded cloths and floor pads to minimize cross-contamination, and using safe cleaning chemicals with low Volatile Organic Compounds (VOCs) that disinfect effectively.
Educational facilities come in a wide variety of shapes, sizes, and types, each of which presents its own particular cleaning challenges. If you consider the fact that schools may be up to four times as densely occupied as a typical office space, creating a protocol to disinfect efficiently can help reduce the spread of germs in an educational facility.
Attention to Educational Facility Cleaning:
Whether you operate a daycare center, private school, public school, or a learning center there are many high traffic areas which require special attention in cleaning. Rooms with special concern in an educational facility cleaning include:
Hallways
Aside from the cleaning of floors and desktops in an educational facility, troublesome germ spots in a school include doorknobs, keyboards, a mouse, water fountains, telephones, toilet handles, and switch plates.
What Educators Can Do:
To keep students, teachers and your school as healthy as possible, you might encourage proper hygiene to your students and staff through hand washing education, as well as respiratory hygiene tips such as the "Dracula Cough" whereby coughing or sneezing in ones shirtsleeve (instead of their hands) can help prevent the spread of germs. If you seek an education facilities cleaning program, you should consider school, community and state standards for cleaning, as well as your school's schedule.
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Remove Chewing Gum - Cleaning Tip
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American pop singer Britney Spears has developed and endorsed a number of products; these have included books, video releases, video games, dolls, clothing, and perfumes. In 2000, Spears released a limited edition of sunglasses titled Shades of Britney. In 2001, she signed a deal with shoe company Skechers, and a $7–8 million promotional deal with Pepsi, their biggest entertainment deal at the time. Aside from numerous commercials with the latter during that year, she also appeared in a 2004 Pepsi television commercial in the theme of "Gladiators" with singers Beyoncé, Pink, and Enrique Iglesias. On June 19, 2002, she released her first multi-platform video game, Britney's Dance Beat, which received positive reviews. In March 2009, Spears was announced as the new face of clothing brand Candie's. Dari Marder, chief marketing officer for the brand, explained why they choose the singer, saying, "everybody loves a comeback and nobody's doing it better than Britney. She's just poised for even greater success." In 2010, Spears designed a limited edition line for the brand, which was released in stores in July 2010. In 2011, she teamed up with Sony, Make Up For Ever and PlentyofFish to release her music video for "Hold It Against Me", earning her $500,000 for the product placement. Spears also teamed up with Hasbro in 2012 to release an exclusive version of Twister Dance, which includes a remix of "Till the World Ends". The singer was also featured on a commercial, which was directed by Ray Kay, to promote the game. Spears was also featured on the commercial of "Twister Rave" and the game included a Twister remix of "Circus". In March 2018, it was revealed that Spears would be the face of Kenzo, a contemporary French luxury clothing house.

Spears's range of commercial deals and products also includes beauty care products and perfumes. She released her first perfume with Elizabeth Arden, Curious in 2004, which broke the company's first-week gross for a perfume. By 2009, she had released seven more perfumes including Fantasy. In 2010, Spears released her eighth fragrance, Radiance. In March 2011, company Brand Sense filed a lawsuit against Spears and Elizabeth Arden seeking $10 million in damages, claiming that she and her father, Jamie, stopped paying their thirty-five percent commission that was agreed as part of the contract terms. In July 2011, a Los Angeles judge denied the request by the company lawyers, claiming the fact that Spears is still under conservatorship. Brand Sense, however, stated that they would appeal the decision. In 2011, Radiance was re-issued as a new perfume titled Cosmic Radiance. Worldwide, Spears sold over one million bottles in the first five years, with gross receipts of $1.5 billion. In 2016, Spears contacted Glu Mobile to create her own role-playing game, Britney Spears: American Dream. The app officially launched in May 2016 and is compatible with iOS and Android. On June 17, 2016, Spears announced the release of her twentieth fragrance, Private Show. , Spears has released 24 fragrances through Elizabeth Arden.

Fragrances
Spears endorsed her first Elizabeth Arden perfume Curious in 2004, and made $100 million in sales in its first year. In September 2005, Spears released the fragrance Fantasy. In April 2006, Spears launched Curious: In Control as a limited edition fragrance. The same year, she released another perfume titled Midnight Fantasy. September 24, 2007 marked the release date of the fragrance collection Believe. She released her sixth perfume, Curious Heart, in January 2008. In December 2008, Spears released two more perfumes with the release of her sixth studio album Circus. In 2009, Curious won the Glammy Award for "Best Beauty Buy of 2009" by Glamour magazine readers, for Best Drugstore Fragrance.

As of 2009, Spears claimed to have sold 30 million bottles worldwide. As of 2012, her fragrances brand had grossed over $1.5 billion worldwide. According to a Daily Express newspaper report in 2013, a bottle of a Spears fragrance was sold every 15 seconds worldwide. In 2018, Spears released her twenty-fifth and first ever unisex fragrance, Prerogative. As of 2022, Spears has released thirty-six fragrances under her brand.

Toys and games

Dolls

In 1999, Play Along Toys released the Britney Spears doll. It was the first product ever released by this toy company. The doll featured Spears with various outfits, make-up and hairstyles from her concerts, appearances, photoshoots and music videos. Yaboom Toys also made a singing Britney Spears doll that would "sing' when you pressed her belly button – along with miniature dolls & Britney concert stages/Tour Bus toy replicas.  The line of merchandise eventually included Britney porcelain dolls.

Video game

Britney's Dance Beat is a one or two player music video game featuring songs and video appearances by Spears. The story is that players must pass "auditions" to tour as Spears' dancers. Gameplay involves pressing buttons in time with music. Symbols for buttons are arranged in a circle, resembling a clock dial. A pointer sweeps around the dial, indicating when to press each button.

The game contains five songs: "...Baby One More Time", "Oops!... I Did It Again", "Stronger", "Overprotected" and "I'm a Slave 4 U". Successful play is rewarded with "backstage passes" which unlocks features such as backstage video footage of Spears.

Mobile games

A cell phone game created by Qplaze-RME and Sony BMG titled Adventures of Britney Spears was announced in December 2005 but was never released. Images and video footage of the game were released along with the game's press release.

Ten years later, Spears started working on a game with Glu. In 2016, she released a casual role play as a pop star game called Britney Spears: American Dream in May 2016 and it sold 500,000 copies. The freemium game was developed by Glu, the company that developed Kim Kardashian: Hollywood.

Clothing
In March 2009, Spears was announced as the new face of Candie's, a clothing brand marketed for pre-teens and teenagers. After being the face of the line for two years, it was announced that Spears would design a limited edition collection for Candie's which would be unveiled by mid year. It premiered on July 1, 2010 with prices ranging from $14 to $78. In an interview with InStyle Magazine's website, Spears announced a few more pieces would be sold in September and October and that she would love to design for them again.

In August 2014, Spears launched an undergarment brand with the Danish company Change Lingerie, for sale online and in Change Lingerie stores.

Books

Britney mentioned she would be writing a memoir in 2022, for the upfront cost of 15M.

Other products
Britney Spears released a range of hair care products in the supermarket chain Lidl in December 2014 in England.

Endorsements
Spears has endorsed several brands throughout her career, including Pepsi, Polaroid, McDonald's, Hasbro, Versace, NFL, Skechers, Got Milk?, Tommy Hilfiger, Clairol, Herbal Essences, Samsung, Nabisco, Virgin Mobile, Zappos, KENZO, Sbarro, ABC, HBO, Candies, Kohls, Starburst candy, Eos, iHeart Radio, Kirin Company, Apple Music, Disney, Los Angeles Dodgers, and Toyota.
She has also included endorsements in her music videos for brands such as Bvlgari, Swarovski, Volkswagen, Mazda, MateFit, PlentyOfFish, Beats Electronics, Sony, Nokia, Lamborghini, and Samsung.

Accolades

Notes

References

Products

redpajama_set_name: RedPajamaWikipedia


Envelope. Siding, boards, squares and timbers.
Local Materials. All products are sources within less than 500 miles, and 70% of our products come from Minnesota forests.
Distribution. Local, regional, national, and international. Distribute primarily to wholesale customers.
True North Woods. The majority of our products are True North Woods certified.
FSC. The company is in the process of applying for FSC certification.
Sawmill, planers, and kilns. NSLB grading.
The company has been family owned since 1914 and is in its third generation.


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Lindre-Basse – miejscowość i gmina we Francji, w regionie Grand Est, w departamencie Mozela.

Według danych na rok 1990 gminę zamieszkiwało 228 osób, a gęstość zaludnienia wynosiła 28 osób/km² (wśród 2335 gmin Lotaryngii Lindre-Basse plasuje się na 817. miejscu pod względem liczby ludności, natomiast pod względem powierzchni na miejscu 737.).

Bibliografia

Miejscowości w departamencie Mozela


It is Valentine's Day and I want to take this opportunity to write about a very important topic: Self Love. I am partnering with CLUSE for their campaign "Time To Love Me" to share my thoughts on this subject with you and give you some tips that help me to be more gentle and kind to myself.
Self love is absolutely vital – especially when we talk about relationships. I believe that we are meant to be in partnership. "Belonging" is essential for our health and well being and we all have a deeply engraved desire to connect. But you cannot truly love anyone until you know how to love yourself. We cannot give what we do not have. It always starts with YOU. If you want deep intimate relationships in your life – and I mean true intimacy, not just physically being with someone – you need to show the people you care about who you really are. And for that vulnerability you need to truly know and accept yourself.


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How did Lord Rama's death, why did Lord Ram give Laxman the death penalty?
Hello friends, how do you feel that you should be all right, God will keep you happy,
Let's start with today's article with another interesting subject,
So friends, do you know how the death of Lord Rama, yes, friends, do you know how Lord Ram died?
Let us tell you today,
It is said that Lord Rama lived on this earth for more than ten thousand years, but in the end he also had to go through this earth,
It is a matter of one day that in the court of Lord Ram, an old saint arrived in the court of Lord Rama and asked him to meet him alone, Lord Rama, taking the saint's request and request, took him to a separate room and at his door The younger brother Laxman was placed as a watchman and said that if he tried to dissolve the discussion of his and that Saint, he would give him death penalty.
Laxman, following the command of his elder brother, left the two in solitude in the room and began to guard himself outside, that old saint was no one else but Kaldev sent from Vishnu people who sent Lord Rama to tell him It was said that his life on earth has been completed and now he will have to return to his dharma,
At the gate of Akhenak, Rishi came to Durvas, he requested Lakshman to go inside the room to meet Lord Rama, but Lakshman refused to do so by following the order of Shri Ram. For which he was always known,
Even after refusing the Laxman, Rishi Durvas did not withdraw from his talk and in the end warned Laxman and Shree Ram to curse which Lakshman was worried as he could not understand that he cursed his brother, Shri Ram Avoid getting or following their commands,
In the end, Laxman decided that he would go inside himself, while he knew that according to Shri Ram, he would have to die, so that he went ahead and went inside the room,
Seeing Laxman growing up in the discussion, Shri Ram also went to Dharam Crisis and asked Lakshman, what was the work or what was it that you had to break through my order, then when Laxman told him the whole story, then Ram also dilemma Lord Rama, who had gone to see him in the dilemma, explained to him that Rishi Vashishth explained to him that you should let Lakshman get his country out of death, because he took his country U is equal to
Then Lord Ram gave away his brother Lakshman to the country; Laxman came away from Asu and immediately joined the side of the river Saryu and folded his hand and restrained his entire senses by stopping his coconut, seeing that all the gods show flowers on them, and Devraj Indra takes them along with their body and goes to heaven,
After Lord Laxman left the earth, Lord Ram decided to give up the people of death, knowing this decision of Lord Shri Ram, all the apes and Vibhishans, including the Sugriva, also came to Ayodhya,
After this, all the monkeys with Lord Ram, Bharat Satguna, decide to leave this folk,
Then Lord Shree Ram refused to leave five people, including Jammant, Hanuman, Vibhishan, and all the monkeys and Ayodhya Vasasi entered the Sarayu river with Lord Shri Ram and merged in the river of Saryu,
So friends were the mysteries of Lord Rama's death which many people do not know.
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Aranos is a farmer's town nestled between beautiful Kalahari dunes to the east of Mariental. Although it only receives about 188mm of rain annually, fresh produce forms a large part of the agricultural industry. Farms and nature reserves are rolled out across the plains and the scenery can be quite stunning. The winds sweep up the red sands into rippling hills scattered with grasses and shrubbery. The town sports a filling station with a workshop, small shops and an information centre that portrays the history of the town and its people. The majestic Kgalagadi Transfrontier Park lies to the east and sprawls over the Botswana and South African borders. Wildlife flourishes in the seemingly dry Kalahari with oryx, springbok and ostrich regularly seen.


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Olivia Benson Quotes That Will Inspire Every Woman to Kick Butt Today
By	Anna Quintana	 January 25, 2018
If there is one female TV character that every girl should look up to, it's Olivia Benson. The crime-fighting superhero — because not all superheroes wear capes — not only lays down the law, but also shares words of wisdom that we should all live by on almost every episode of Law and Order: Special Victims Unit. Trust us — we've seen them all twice.
In honor of Mariska Hargitay's 54th birthday, we are looking back at her most powerful quotes on the police procedural. And now, more than ever, her words are inspirational and insightful. Nearly two decades since it's premiere, Mariska continues to bring to the small screen Olivia's compassion, but also her "I am woman, hear me roar" attitude.
"I'm still here because it's still challenging and interesting to me. I feel like we keep going deeper and mining out these new places. After 12 years [of doing the show], I thought, 'What are we going to do after 12 years?' It was such an education for me because I had no idea,'" Mariska said in 2016 of her iconic role. "It's very exciting to me… and it still feels utterly fresh."
(Photo Credit: NBC)
That's not to say Olivia's backstory is not without its challenges. The daughter of an alcoholic mother and an abuse victim herself, Olivia can relate to the victims she encounters episode after episode on the NBC drama. She is proof that what doesn't kill you makes you stronger. In the words of Olivia herself, "We're all branded I guess. By our parents, our childhoods."
We shouldn't be surprised Olivia continues to be our girl crush and daily inspo — there is a reason Taylor Swift named one of her cats after her. Keep scrolling for even more Olivia Benson quotes!
This article originally appeared on our sister site, Life & Style.
Olivia Benson 6
"Everybody changes every day and some things are more devastating than others, but we never are the same, and there are two ways to deal with these changes: you either accept them or you fight them like hell all the way."
— Season 1, episode 10
Olivia Benson 10
"I trust my instincts. If I don't have that, I shouldn't be here."
— Season 13, episode 17
"Once you tell your story, it can be empowering."
"There are two things that you need to know about me. First — I like an open and free exchange of ideas. And second — I'm usually right."
— Season 17, episode 8
"Some things, you can put them behind you... but they do change you."
"Healing begins when someone bears witness. I saw you. I believe you."
"Running away doesn't make it over."
"I don't need anybody to hold my hand."
"Nothing changes... except what has to."
"Don't you just hate to see a grown man cry? Highlight of my day. "
"You think I'm a b---h, don't you? You're not the first."
Gayle King Shares 5 Ways She Finds Happiness During the Holidays
John Travolta Makes Heartwarming Pledge to Olivia Newton-John Amid Her Third Battle With Breast Cancer
The actress wants her 'Grease' co-star to be there for her daughter.
14 Famous Ladies Who Found Love With Younger Men
Age really is just a number when it comes to falling in love.
The Real Reason Dolly Parton Never Had Any Kids of Her Own
It kind of feels like she's a mom to all of us though, right?
Jane Seymour Shares Her Keys to Embracing Vibrant Energy
Kate Middleton Has a Refreshing and Healthy Favorite Lunch
Ralph Macchio Has the Cutest Story About Meeting His Wife When He Was 15
Naomi Watts Reveals Her Lessons in Life and Love
How Long Do Christmas Leftovers Last?
The Relatable Reason Prince Philip Prefers Eating Without Queen Elizabeth
Meghan Markle and Prince Harry Announce Exciting New Charitable Project


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Comparative advantage – definition and meaning
Comparative advantage is an economic concept that a nation should specialize. Specifically, it should specialize in making and exporting only products which it can produce more efficiently than other goods.
It should specialize even if it has superior productivity in making all goods compared to another country. Furthermore, comparative advantage says that the country should import the goods it does not make.
Imagine there are two countries, Nation A and Nation B. Nation A knows how to make cars and airplanes, while Nation B only knows how to make cars. Productivity in car-making in Nation A is slightly superior to Nation B's.
Nation A would be better off making just airplanes and importing cars from Nation B because airplanes sell for much more money. In other words, Nation A can buy many more cars if it imports them and just makes planes.
If Pam knows how to do Ann's work, why doesn't she do everything herself? Her secretary's wages bill would be saved, wouldn't they? Yes, they would, but her practice would earn considerably less money.
What happens if Nation B only makes cars and Nation A just makes airplanes? They can trade so that the two countries end up with both cars and planes.
Nation A's workers can buy more cars per head of population if they just make planes. Total production and consumption of Nation A and Nation B combined is considerably greater.
We can apply the theory of economic advantage to whole economies and companies. We can also apply it to people.
Comparative advantage – definition
According to the Financial Times Lexicon, comparative advantage is:
"The idea that a country or region should specialize in making and exporting goods and services that it can produce most efficiently."
"In turn, the country should import goods and services that it has a comparative disadvantage producing. This should in theory lead to an increase in overall trade."
Economist David Ricardo used the comparative advantage theory to explain why nations engage in international trade. Communities in total isolation fall rapidly behind technologically.
Absolute vs. comparative advantage
Comparative advantage and absolute advantage are terms we often use in the same text. However, their meanings are quite different.
Imagine a lawyer and her secretary. This lawyer can type faster and is better at producing legal services than the secretary. The lawyer has an absolute advantage over the secretary.
Even so, both people benefit thanks to their comparative advantages as well as disadvantages. Let's suppose that legal services and secretarial duties charge $150 and $25 per hour respectively.
The lawyer is capable of providing both legal and secretarial services. On the other hand, the secretary can only provide secretarial duties.
However, for every hour the lawyer spends on secretarial work, she is not earning $150 by practicing law. Consequently, she loses a net $125. The lawyer would be better off working full-time as a lawyer and employing a full-time secretary.
40-hour week compared
Look at the difference in income below for a 40-hour week:
Lawyer just does secretarial work and has no help:
$25 x 40 hours = $1000
Lawyer practices law full-time and employs a full-time secretary:
Lawyer's fees of $150 x 40 hours = $6,000. Minus secretary's wages of $1,000 ($25 x 4).
The net income for the week is $5,000
The lawyer can do the secretary's job. Nevertheless, she earns much more by delegating the secretarial work to an employee.
The opportunity cost in employing a secretary is very low. This is where her comparative advantage lies.
Opportunity cost refers to how much you have to give up by not doing something. Therefore, in this case, the opportunity cost is the lawyer giving up doing secretarial work.
Thomas Sowell, an American economist, and social theorist is currently Senior Fellow at the Hoover Institution at Stanford University. He writes from a conservative libertarian viewpoint, advocating supply-side economics. (Image: aei.org)
David Ricardo (1772-1823) developed the classical theory of comparative advantage in 1917. Ricardo was a British economist who academics today consider as one of the most influential of the classical economists. He also introduced the Ricardian equivalence proposition.
He used it to explain why nations engage in international trade. They trade even when one country's workers are more efficient in producing every single product than those in another.
Ricardo showed what happens if two national economies, which can produce two commodities, engage in international trade.
They subsequently consume more by exporting the product for which they have a comparative advantage while importing the other product. However, there must be a difference in labor productivity between the two nations.
Ricardo's theory implies that comparative advantage, and not absolute advantage, is responsible for the bulk of international trade.
David Ricardo was born in London; he was third of seventeen children of a Sephardic Jewish family of Portuguese origin. American economists rank him as the second most influential economic thinker, after Adam Smith, before the 20th century. (Image: Wikipedia)
Scottish political economist Adam Smith (1723-1790) first alluded to this idea as the basis for international trade. He did so in the publication of The Wealth of Nations in 1776. Many modern economists say Smith was the 'father of modern economics.'
The concept of comparative advantage appeared in Ricardo's book – On the Principles of Political Economy and Taxation – published in 1817.
Video – What is comparative advantage?
This Marginal Revolution University video explains what comparative advantage is. It also tells us why it is crucial not only for international trade but also for the technological advance and often very survival of communities and civilizations.
The history of Tasmania, off the south coast of Australia, is given as an example.


Hmm... unfortunately, not that I can think of. There really isn't a way to trick a modem into believing it's handshaking without actually having it handshake with another modem. You can use a serial cable to connect the two, that's not a problem but if the modem is expecting the modem connection sequence in response, there's no way for a serial port of any variety to approximate that. Really, the only way to get it to do what you want would be to connect a modem and phone line to the PC and have PageGate's GetTAP module monitor the modem. Then tell your sending modem to dial whatever number is plugged in to the modem PageGate's GetTAP module is monitoring.
We have done exactly this in many callcenters nationwide. The trick is to use the getTAP module to watch a serial port and set the init string to "direct"
Use a NULL modem cable (NOT a straight through Serial cable) to connect the ports on the SENDING and RECEIVING system.
Remember that, when the TAP spec was first written, the intention was to use it for DIRECT SERIAL CONNECTION to a paging terminal.
Wait... you CAN actually trick a modem into passing over TAP without handshaking first? I thought that was limited to direct serial connections between a transmitter and a computer. I thought if a modem was in any stage of the process, you had to do dialup because of the modem's requirement for a handshake?
Yes - the "Handshake" is supplied by PageGate through the serial port.
In this example, the SENDING system THINKS it is sending an alphanumeric page to a paging company terminal. PageGate emulates the terminal to take the message and tell the sending system that it is done. PageGate then reads the ID/PIN and retransmits the text to a cellular phone as an SMS (using an attached supplied cellular modem). In this case, a copy of the message is also wrotten to a text file for use by another internal legacy system.


The SqlConnectionStringBuilder was introduces in .NET 2.0 that is used to build the database connection string specific for the SQL Server .
The SqlConnectionStringBuilder is defined in the namespace System.Data.SqlClient and can help you build the connection string or even parse an existing connection string to retreive the properties .
AsynchronousProcessing to indicate if the asynchronous processing is allowed for the connection .
what a luck, exactly what I need for today 🙂 Lucky me 😀 Thx! Very useful snippet!


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3 doors down another 700 miles album
Check out Another Miles (Live At The Congress Theater, Chicago/) by 3 Doors Down on Amazon Music. Stream ad-free or purchase CD's and MP3s now on lageneraltv.com(33). Stream Another Miles (Live At The Congress Theater, Chicago/) by 3 Doors Down and tens of millions of other songs on all your devices with Amazon Music Unlimited. Exclusive discount for /5(34). Oct 29, · 3 Doors Down Licensed to YouTube by UMG (on behalf of Republic / Universal); LatinAutor, UMPI, UBEM, CMRRA, UMPG Publishing, LatinAutor - UMPG, and 3 Music Rights Societies.
Oct 29, · 3 Doors Down Licensed to YouTube by UMG (on behalf of Republic / Universal); LatinAutor, UMPI, UBEM, CMRRA, UMPG Publishing, LatinAutor - UMPG, and 3 Music Rights Societies. Stream Another Miles (Live At The Congress Theater, Chicago/) by 3 Doors Down and tens of millions of other songs on all your devices with Amazon Music Unlimited. Exclusive discount for /5(34). 3 Doors Down 3 Doors Down is an American rock band from Escatawpa, Mississippi formed in The band originally consisted of Brad Arnold (vocals/drums), Todd Harrell (bass) and Matt Roberts (guitar). They took in Chris Henderson in the very early days of The Better Life's creation and released the album . Nov 11, · Listen to your favorite songs from Another Miles (Live At The Congress Theater, Chicago/) by 3 Doors Down Now. Stream ad-free with Amazon Music Unlimited on mobile, desktop, and tablet. Download our mobile app now. Another Miles is a live EP by 3 Doors Down released on November 11, It was recorded live at a performance in Chicago, Illinois during the band's Away from the Sun tour. The EP's name is derived from the lyrics of their song "I Feel You", which appears on their album Away from the Sun. Track listingGenre: Post-grunge, hard rock.Tracklist with lyrics of the album ANOTHER MILES [EP] [] from 3 Doors Down, including the top song: Here Without You. Click here. Find album reviews, stream songs, credits and award information for Another Miles - 3 Doors Down on AllMusic - - Another Miles is a holdover EP. All the great songs and lyrics from the "Another Miles [EP]" album ont he Web's largest and most Another Miles [EP] album by 3 Doors Down. 3 Doors. 3 Doors Down - Another Miles - lageneraltv.com Music. this album has 7 (live recorded songs on it and this album is only 28 minutes long. Read more. Another Miles is a live EP by 3 Doors Down released on November 11, . It was recorded live at a performance in Chicago, Illinois during the band's Away from the Sun tour. The EP's name is derived from the lyrics of their song "I Feel You", which appears on their album Away from the Sun.
3 Doors Down - Here Without You (Live), time: 4:12
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Leaders and problem-solvers, the attorneys in our Environmental & Remediation Group are at the forefront of the ever-evolving field of environmental law and compliance. We employ a sophisticated, collaborative approach that focuses on our clients' business objectives while identifying strategies for minimizing environmental exposure.
Brownstein's team works with clients nationwide on virtually every aspect of environmental law. Our experience includes solid and hazardous waste, development of Brownfield sites, Superfund liability, water and air quality, underground storage tanks, protection of endangered species, natural resource protection and advice concerning legislative and rulemaking developments in the environmental arena.
With an average of more than two decades experience in the environmental field, the group's attorneys have the experience and knowledge to provide invaluable assistance in the most complex transactional, regulatory or litigation matter, including the Comprehensive Environmental Response, Compensation, and Liability Act; Resource Conservation and Recovery Act; the Clean Water Act; the Clean Air Act; the Endangered Species Act and other environmental statutes.
Members of the group have worked for Congress and for federal and state agencies, including Congressional energy committees, the Departments of Energy and Interior, the Department of Justice, the Environmental Protection Agency and the Colorado State Attorney General's office. Because we have worked on environmental and remediation issues from within the government, we have an excellent understanding of the system, which helps us obtain the best possible results for our clients.
Has represented the Hollister Ranch Owners Association on issues relating to the Coastal Act. In recent years, Brownstein has represented the Association in litigation against the California Coastal Commission and State Coastal Conservancy related to public access.
Represented property owner in a multi-week jury trial involving damage relating to the property's natural resources.
Represents a number of oil and gas companies in obtaining state and local government land use and operating permits either through negotiation or litigation. Representation includes assisting companies in royalty, operating, and antitrust disputes with other operators.
Defended action taken in furtherance of the City of Long Beach's major clean air initiatives based on alleged violation of the Open Meeting Law, alleged improper delegation of police powers and alleged violations of the California Environmental Quality Act.
Represent a major California water district in an appeal to the Ninth Circuit concerning an endangered species in the San Joaquin Valley in California.
Helped obtain funding for an innovative bioremediation project to remove a chemical pollutant from drinking water.
Assisted Slaterpaull Architects in acquiring historic real property from the City & County of Denver and with related environmental and rehabilitation tax credit matters.
Successfully defended one of the largest landfill operators in the country against allegations of non-compliance with air regulations and permits at the companies' facilities in Colorado. The resulting civil penalties were well below SEC reporting obligations for this publicly traded company.
Successfully defended GCC, a coal mining operation in Hesperus, CO, against CDPHE allegations that the facility failed to obtain all required permits. The resulting fine was $10,000 when penalties could have exceeded half a million. Negotiated the return of over $5 Million of cash funded reclamation obligations for the limestone mine at the GCC facility in Pueblo, Colorado.
Successfully represent a non-profit entity in Endangered Species Act listing litigation.
Represented an energy company in a challenge on state and federal preemption grounds to County regulations governing oil and gas operations.
Represent a large electrical utility in a Clean Air Act investigation of a coal fired power plant. The EPA investigation covers over 25 years of documents and environmental and operational data at the multi-unit power plant. Representation involves advising the utility on its response to the agency and managing the production of tens of thousands of documents and data.
Successfully represented interests of private property owners in Santa Barbara regarding proposal by an organization to paint blue waves across 68 city streets depicting a potential flood zone, which would have devalued hundreds of homes and businesses.
Represented a large development company on the investigation and remediation of soil and groundwater contamination on a 65 acre parcel in the Central Platte Valley and worked closely with the State to obtain approval of Voluntary Clean Up Plans and No Further Action letters for this contaminated and environmentally-sensitive area.
Represented a major home developer in the demolition of the CU Health Sciences Center and the redevelopment of this area for mixed commercial and residential use. Matter involved asbestos and radioactive material abatement, and hazardous and medical waste remediation in over 15 medical buildings.
Represented city to insure that environmental documents prepared by city appropriately evaluated the global warming impacts created by the projects in city planning documents.
Kern County/Department of Toxic Substance Control administrative civil actions against client City of Oxnard regarding the storage and handling of biosolids. Successfully negotiated fines and remedy.
Property contamination requiring remediation, CERCLA 104(e) response. Drafted complex sale and indemnity agreement.
Negotiated settlement with insurer of $9M regarding dioxin contamination; commenced action against LADWP (settled).
Property contamination requiring remediation. Negotiated approvals with agencies, approved cleanup.
Represented a large electric utility in an enforcement action containing numerous alleged violations of the Clean Air Act against one of its coal-fired generating stations. The enforcement action was brought by the Nevada Division of Environmental Protection, the United States Environmental Protection Agency and the United States Department of Justice. After considerable time and effort, the company was able to negotiate a complex settlement with all parties in the form of a consent decree filed in U.S. District Court. The settlement included a fine significantly less than the fine amounts initially proposed by the governments. In addition, the consent decree involved several supplemental environmental projects, including the creation of environmental reduction credits.
Represented a major hotel developer in inverse condemnation and CEQA actions related to the Sacramento County Airport expansion.


Lumineon are perciformes with an interesting choice of habitat; Finneon spend their days in sunlit coral reefs before returning to the depths of the ocean at night, while Lumineon wander along the sea floor on their fins. Their main competition for food is Lanturn, who are also bioluminescent deep-sea dwellers. Without the electrogenetic capabilities that Lanturn have, however, Lumineon seem to be at an immediate disadvantage. Scientists believe that these Pokémon evolved to trawl the very bottom of the sea to avoid direct conflict with Lanturn, as they have settled for whatever scraps have floated down from the ocean's surface.
Finneon graze on algae and coral polyps in productive coral reefs. Lumineon use their bioluminescence to attract and hunt small fish and invertebrates like Starmie deep below in ocean trenches, where food is far more scarce.
Though these Pokémon are naturally deep-sea dwellers, they are actually tolerant of a wide range of pressures and salinities (some Finneon can even survive entirely in fresh water). Finneon function on a standard day-night cycle with regular, consistent periods of sunlight each day. Constant artificial lighting or irregular periods of darkness can cause them stress. Lumineon prefer to rest on sandy substrate at the very bottoms of their enclosures.


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Written on June 20, 2013 . Posted in Fine Arts, Liberal Arts, Updates from & for Faculty.
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Tag: omicron variant
Biden White House Ramps Up Delivery Of Free COVID Tests And KN-95 Masks
The Biden administration is taking several steps to address the latest wave of COVID-19, including the creation of a response team designed to head off possible future variants of the coronavirus.
Experts say the month of February will likely be "tough" in terms of omicron, though there are signs that the wave may be peaking as reported infections and hospitalizations slow. Health officials are simultaneously concerned about future variants developing and groups like the World Health Organization and the Centers for Disease Control continue to monitor the ever-changing situation.
The White House Office of Science and Technology Policy, meanwhile, has made moves to address the crisis, recently launching the Pandemic Innovation Task Force, which is focused on developing treatments, vaccines, testing, and other tools to respond to variants that may appear within six months to two years.
Eric Lander, who serves as President Joe Biden's science adviser, leads the group along with Dawn O'Connell, assistant secretary for preparedness at the Department of Health and Human Services. Bloomberg reported that the task force builds on the $65.3 billion, 10-year pandemic preparedness plan released by the White House in September to coordinate efforts across the government in the event of future outbreaks.
That plan is a reversal from former President Donald Trump, whose team, upon taking over, discarded the pandemic preparedness plan left in place by President Barack Obama's team and left the Office of Science and Technology Policy director seat vacant for two years.
The Biden administration on Tuesday also launched an official website to offer COVID-19 tests to every American household, a day ahead of the scheduled launch.
The site, COVIDtests.gov — which allows each household to order 4 free at home COVID-19 test kits, to be delivered by the U.S. Postal Service — immediately attracted hundreds of thousands of visitors and was the most visited federal government page. According to the official federal government analytics site, it received over 47 million visits in its first 48 hours of operation.
On Wednesday, the Biden administration also announced that it would make 400 million N95 masks available to Americans for free. The masks are being sourced from the Strategic National Stockpile and will be sent to local pharmacies and community health centers for anyone to pick up.
The U.S. Centers for Disease Control and Prevention updated its guidance on Jan. 14 to reflect the fact that N95 caliber masks, in comparison to cloth masks, "offer the highest level of protection" against COVID-19 infection.
Biden has publicly voiced support for masks since the height of the pandemic in 2020 and has continued to publicly mask himself while promoting vaccination efforts.
Republished with permission from American Independent
Fox News Promotes Its Dumbest Anti-Vax Lie To Date
Alicia Sadowski
Amid a surge in COVID-19 cases due to the Omicron variant, Fox News has been relentlessly undermining the vaccination effort, including by recklessly misinterpreting a Danish study on vaccine efficacy against the latest variant.
The study, circulated by professional COVID-19 "contrarian" Alex Berenson and mentioned in a Wall Street Journal op-ed, was originally published on medRxiv, a website for preliminary studies that have not been peer-reviewed. A warning on the website states the studies "should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information."
This warning did not stop Fox hosts and personalities from citing the study and cherry-picking data to claim that vaccination makes it more likely for an individual to contract COVID-19. The study found that 90 days post "vaccine protection," or the date 14 days post-second dose, both the Pfizer and Moderna vaccine had negative vaccine efficacy. The authors of the study, however, explained the unusual result as "different behavior and/or exposure patterns in the vaccinated and unvaccinated cohorts causing underestimation of the vaccine efficacy."
In an email to PolitiFact, one of the authors of the study also suggested that the negative efficacy could be explained by the fact that vaccinated people may test more than unvaccinated people and an overrepresentation of vaccinated people in the studied cohort. Furthermore, Fox hosts and personalities failed to convey the authors' conclusion that "booster vaccination offer[s] a significant increase in protection" and that their "findings highlight the need for massive rollout of vaccinations and booster vaccinations."
Article reprinted with permission from Media Matters
Biden Orders Insurance Companies To Cover Eight Monthly COVID Tests
WASHINGTON (Reuters) - Insurance companies will be required to cover eight over-the-counter at-home coronavirus tests per person each month starting Saturday, the Biden administration said, expanding access to highly sought-after kits as Americans grapple with a surge in coronavirus cases.
The White House also said on Monday that there is no limit to the number of COVID-19 tests, including at-home tests, that insurers must cover if they are ordered or administered by a health care provider.
The measures are part of a bid by President Joe Biden to make testing more widely available to Americans facing soaring coronavirus cases due to the highly infectious Omicron variant.
In a speech in December, Biden outlined plans to distribute 500 million at-home coronavirus test kits and stand up new federal testing sites, adding to the 20,000 already in existence. However, experts decried the announcement as "too little too late" amid testing shortages nationwide.
White House Press Secretary Jen Psaki said on Monday that Americans should be able to order the tests online later this month, noting that all contracts for rapid tests should be awarded over the next two weeks. The first was signed last week.
Under the insurer coverage plan announced Monday, the administration said that insurers are still required to reimburse tests purchased by consumers outside of their network, at a rate of up to $12 per individual test.
It was not immediately clear what incentives were offered to insurers to agree to the plan. The Department of Health and Human Services did not immediately respond to a request for comment.
(Reporting by Eric Beech and Alexandra Alper; Editing by Chris Reese and Cynthia Osterman)
Airport Chaos As More Than 2,600 US Flights Are Cancelled
Washington (AFP) - Air travel continued to be severely disrupted in the United States on Saturday, with bad weather in parts of the country adding to the impact of a massive spike in Covid-19 infections fuelled by the Omicron variant.
The United States had 2,604 cancelled flights, more than half of the 4,529 cancelled worldwide, shortly after 4:30 pm (2130 GMT), according to tracking website FlightAware.
In addition, 3,447 domestic flights were delayed on Saturday, out of a total of 7,602 worldwide for the day.
The worst affected US airline was Southwest, which had to cancel 13 percent of its flight schedule, according to the site.
In the United States, airports in Chicago were particularly hard-hit because of difficult weather, with a snowstorm expected in the area on Saturday afternoon and into the night.
The global air travel industry is still reeling from the highly contagious Omicron variant.
Many pilots, flight attendants and other staff are absent from work after contracting Covid-19, or because they are quarantining after coming in contact with someone who has the infection.
Some 7,500 flights were cancelled by airlines worldwide over the Christmas weekend.
S&P 500 Hits Record Close As Omicron Fears Subside
By Lewis Krauskopf, Medha Singh and Bansari Mayur Kamdar
(Reuters) - Wall Street's main indexes posted solid gains for a third straight session on Thursday, with the S&P 500 marking a record-high close, as encouraging developments gave investors more ease about the economic impact of the Omicron coronavirus variant.
Stocks ended the holiday-shortened week on a positive note, lifting sentiment heading into Christmas. Gains were broad among S&P 500 sectors, led by consumer discretionary and industrials, which both rose about 1.2 percent.
Vaccine makers AstraZeneca Plc and Novavax Inc said their shots protected against Omicron as UK data suggested it may cause proportionally fewer hospital cases than the Delta variant, though public health experts warned the battle against COVID-19 was far from over.
The arrival of Omicron has helped ratchet up market volatility for much of the last month of 2021, which has been a strong year for equities.
"There was a lot of negative sentiment coming into the final part of the year, and investors have likely continued to see pretty strong economic growth and pretty positive developments as it relates to healthcare innovation around COVID and that is putting in a bit of a bid into equities and causing investors to look to allocate capital as they close out the year," said Matthew Miskin, co-chief investment strategist at John Hancock Investment Management.
The Dow Jones Industrial Average rose 196.67 points, or 0.55 percent, to 35,950.56, the S&P 500 gained 29.23 points, or 0.62 percent, to 4,725.79 and the Nasdaq Composite added 131.48 points, or 0.85 percent, to 15,653.37.
Defensive sectors, which have mostly outperformed in December, generally lagged on Thursday. The real estate sector fell 0.4 percent.
The S&P 500 has gained for three days, after falling in the three prior sessions.
"People are seeing the strength on Tuesday and Wednesday and all of a sudden everybody is more optimistic again," said Robert Pavlik, senior portfolio manager at Dakota Wealth Management.
For the week, the S&P 500 rose 2.3 percent, the Dow gained about 1.7 percent and the Nasdaq climbed 3.2 percent.
Trading volumes were expected to be thinner than usual ahead of the Christmas and New Year holidays. The stock market will be closed on Friday in observance of the Christmas holiday.
In another medical development against the pandemic, the United States authorized Merck & Co's antiviral pill for COVID-19 for certain high-risk adult patients, a day after giving a broader go-ahead to a similar but more effective treatment from Pfizer Inc. Merck shares fell 0.6%, while Pfizer dropped 1.4 percent.
The number of Americans filing new claims for unemployment benefits held below pre-pandemic levels last week as the labor market tightens, while consumer spending increased solidly, putting the economy on track for a strong finish to 2021.
Tesla Inc shares rose 5.8 percent, gaining sharply for a second day after chief executive Elon Musk said on Wednesday he was "almost done" with his stock sales after selling over $15 billion worth since early November.
The S&P 500 is up about 26% so far this year. Still, the environment for equities could be changing heading into next year as the Federal Reserve is expected to begin raising interest rates in 2022.
Advancing issues outnumbered declining ones on the NYSE by a 2.40-to-1 ratio; on Nasdaq, a 2.22-to-1 ratio favored advancers.
The S&P 500 posted 35 new 52-week highs and no new lows; the Nasdaq Composite recorded 62 new highs and 80 new lows.
About 8 billion shares changed hands in U.S. exchanges, compared with the 11.8 billion daily average over the last 20 sessions.
(Reporting by Lewis Krauskopf in New York, Medha Singh and Bansari Mayur Kamdar in Bengaluru; Editing by Uttaresh.V and Matthew Lewis)
Large Holiday Gatherings In U.S. Unsafe Even For Boosted, Fauci Warns
By Ahmed Aboulenein and Katharine Jackson
WASHINGTON (Reuters) - Americans vaccinated and boosted against COVID-19 can be with family over the holidays but attending large gatherings is not safe, even for those who received a booster dose, top U.S. infectious disease expert Anthony Fauci said on Wednesday.
The United States faces a second Christmas of upended holiday plans, with a surge in infections fueled by the now-dominant Omicron variant of the coronavirus forcing many to cancel travel, reconsider visiting loved ones, and question attending holiday parties.
"There are many of these parties that have 30, 40, 50 people in which you do not know the vaccination status of individuals. Those are the kind of functions in the context of Omicron that you do not want to go to," Fauci said at a White House briefing.
Early evidence indicates Omicron is less severe than the Delta variant, said Fauci, citing studies from South Africa and Scotland, but warned Americans must remain cautious.
"This is good news. However, we must wait to see what happens in our own population which has its own demographic considerations," he said.
The seven-day average of COVID-19 cases in the United States rose 25 percent from the previous week to about 149,300 cases per day, said U.S. Centers for Disease Control and Prevention Director Rochelle Walensky, with average daily deaths up 3.5 percent at 1,200.
Omicron represents approximately 73 percent of cases across the country, said Walensky, and as high as 90 percen of cases in some areas, such as the eastern Atlantic states, parts of the Midwest, South, and northern Pacific states.
"This increase in Omicron proportion is what we anticipated and what we have been preparing for," she said.
The U.S. government will have 265,000 treatment courses of Pfizer Inc's COVID-19 anti-viral treatment available by January and 10 million by late summer, said White House COVID-19 response coordinator Jeff Zients.
The Food and Drug Administration on Wednesday authorized Paxlovid, Pfizer's pill for at-risk people aged 12 and above.
The government will provide any resources Pfizer needs for production and will distribute treatments to states and localities at no charge as soon as they are delivered, he said.
(Reporting by Ahmed Aboulenein and Katharine Jackson; Additional reporting by Caitlin Webber in Washington and Kanishka Singh in Bengaluru; Editing by Leslie Adler and Alistair Bekk)
Even Donald Trump Himself Cannot Sell MAGA Extremists On COVID Vaccines
During a recent event with former Fox News host Bill O'Reilly, former President Donald Trump was booed by some anti-vaxxers after revealing that he had received a COVID-19 vaccine booster. Trump insisted that the MAGA movement deserves the credit for COVID vaccines, but that messaging didn't persuade the anti-vaxxers who booed him. Discussing this incident in an op-ed published on December 20, Washington Post opinion columnists Paul Waldman and Greg Sargent lament that anti-vaxxer sentiment is so ingrained in the MAGA movement at this point that even Trump himself cannot convince far-right anti-vaxxers to get vaccinated.
Not everyone in Trumpworld is pushing anti-vaxxer arguments. Former White House Press Secretary Sarah Huckabee Sanders, who is running for governor of Arkansas, describes COVID-19 vaccines as "the Trump vaccine." And Trump has similar messaging, arguing that his supporters should hail COVID-19 vaccines as a MAGA achievement instead of rejecting them.
Trump told the crowd, "Look, we did something that was historic. We saved tens of millions of lives worldwide. We together, all of us — not me, we — we got a vaccine done, three vaccines done, and tremendous therapeutics … This was going to ravage the country far beyond what it is right now. Take credit for it. Take credit for it. It's great — what we've done is historic. Don't let them take it away…. If you don't want to take it, you shouldn't be forced to take it. No mandates. But take credit because we saved tens of millions of lives. Take credit. Don't let them take that away from you."
The response to those comments, Waldman and Sargent note, was "boos from at least some in the crowd."
"There is clearly a good portion of the Republican base that in this case, finds the truest expression of Trumpism in rejecting what Trump himself is telling them," Waldman and Sargent write. "Opposition to vaccines has been woven so tightly into their political identity that not even Trump himself can remove it."
But as Waldman and Sargent point out, being an anti-vaxxer has become a badge of honor in MAGA World.
"For some time, we've heard reports of people who live in conservative communities getting secretly vaccinated, fearful of letting others around them know they've gotten a vaccine," the columnists point out. "It's reasonable to assume some people in liberal communities likewise lie about having been vaccinated. The idea that one's political identity requires fighting against vaccines is constantly reinforced from all directions, whether by conservative media or politicians who are responsive to what they know their constituents are hearing…. Red states that are this far down this road are not going to immediately reverse course now that Trump is suddenly talking sense on this matter."
Article reprinted with permission from Alternet
With Warning For Unvaccinated, Biden Reveals Plan To Fight Surging Omicron
By Steve Holland and Jarrett Renshaw
WASHINGTON (Reuters) - President Joe Biden announced on Tuesday more federal vaccination and testing sites to tackle a surge in COVID-19 driven by the Omicron variant, and said 500 million free at-home rapid tests will be available to Americans starting in January.
Biden offered both a warning to the unvaccinated, who he said have "good reason to be concerned," and reassurance that those who are inoculated can gather for the holidays despite the new variant sweeping the country.
"No this is not March of 2020," Biden told reporters at the White House. "Two hundred million people are fully vaccinated, we're prepared, we know more."
Biden's remarks came as some cities and states imposed new measures aimed at protecting the public, including stricter vaccine mandates.
Striking a dire tone about the risks to the one-in-four American adults who are not fully vaccinated, Biden said they "have a significantly higher risk of ending up in the hospital or even dying."
Biden noted that former President Donald Trump has also received his booster shot. "Maybe one of the few things he and I agree on," he said.
The measures laid out on Tuesday include activating new pop-up vaccination clinics run by the Federal Emergency Management Agency and federal testing sites starting this week, including in hot spot New York City.
Biden also said that some 1,000 military doctors, nurses and medics have been deployed to support hospitals already being overwhelmed by COVID-19 patients in some areas.
Biden's pandemic response has been criticized for focusing on vaccines at the detriment of testing and masking, and for underestimating the impact of the anti-vaccine movement in the United States.
In his speech, Biden said Americans had a patriotic duty to get vaccinated and called out social media companies and TV networks for "peddling lies and allowing misinformation that can kill their own customers."
The new federal measures will not be fully in place by Christmas, leaving many Americans scrambling to find available tests ahead of holiday gatherings and travel - and confused about whether it is safe to press ahead with their plans.
The Omicron variant, which was first detected last month and now accounts for 73 percent of U.S. cases, is causing infections to double in 1.5 to 3 days, according to the World Health Organization. It is not yet known whether it causes more serious illness than the Delta variant.
The rapid rise of infections is once again disrupting life across the country, canceling events from Broadway shows to professional sports.
In New York, Washington, and other U.S. cities there were long lines for COVID-19 tests as people sought to find out if they were infected before celebrating the holidays.
"If I don't, I could take a chance of sending it home to my family, and I'm not trying to do that," said Ronald Tives as he lined up in Washington's Farragut Square on Tuesday.
$100 For A Booster In New York City
With new infections spiking, local officials are also taking steps to encourage vaccinations, including boosters, and increase testing and mitigation measures.
New York City Mayor Bill de Blasio announced on Tuesday a $100 incentive for residents who get a COVID-19 vaccine booster at city-run sites by the end of the year.
The city's public hospitals said they would ban most visitors. Starting on Wednesday, only hospitalized infants and children, women in labor and dying patients can have visitors. They must be fully vaccinated or show a negative COVID-19 test from the past 24 hours.
In California, Governor Gavin Newsom said on Twitter that all healthcare workers would be required to receive booster vaccines. The state is expected to announce additional measures on Wednesday.
Chicago will require patrons to present proof of COVID-19 vaccinations for entry to restaurants, bars, gyms and some other indoor spaces, effective January 3, Mayor Lori Lightfoot said on Tuesday.
Biden noted that the Omicron variant is so contagious that it will infect vaccinated Americans but that they will be far less likely to become seriously ill.
These breakthrough infections are rising among the 61 percent of the country's fully vaccinated population, including the 30 percent who have gotten booster shots.
Still, Biden told Americans that those who are vaccinated and follow guidance around using masks, especially while traveling, should feel comfortable celebrating the holidays as planned.
New COVID-19 cases rose 19 percent in the United States in the past week and are up 72 percent since the start of December, according to a Reuters tally.
The number of hospitalized COVID-19 patients has increased 27 percent this month, with hospitals in some areas already strained by the Delta variant that emerged earlier this year.
There have been more than 51 million infections and 810,000 coronavirus-related deaths reported in the United States since the pandemic began, the most of any country.
(Reporting by Jarrett Renshaw and Ahmed Aboulenein; Additional reporting by Lisa Shumaker and Sharon Bernstein; Writing by Maria Caspani; Editing by Peter Cooney, Bill Berkrot, Sonya Hepinstall and Cynthia Osterman)


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text:
Interview & Giveaway for The Last One by Tawdra Kandle
posted by Unknown , on 12:01 AM , 1 comment
The Last One by Tawdra Kandle
Genres: Contemporary, New Adult, Romance
Meghan Hawthorne is restless. The last year has been a roller coaster: her widowed mother just married a long-time family friend. Her younger brother unexpectedly became a father and a husband. Everyone's life is changing. . .except for hers. As she begins her final summer of college, Meghan's looking for excitement and maybe a little romance. Nothing serious; this girl just wants to have fun.
But the only man for Meghan turns out to be the last one she expects.
Sam Reynolds doesn't need excitement, and he doesn't want romance. Fun is out of the question. He's been the steady, responsible one since his parents were killed, and serious is his way of life.
When Sam rescues Meghan alongside a dark Georgia backroad, she falls hard for his deep brown eyes and slow drawl. But making him see her as more than just a party girl won't be easy. Sam's tempted by the fiery young artist, even as he realizes that giving into his feelings will mean radical change. . .maybe more than he can handle.
Nobody ever said love was simple.
Purchase: Amazon | B&N
Q: Tell us a little about Meghan and Sam, the couple in THE LAST ONE.
A: Meghan just finished her junior year at art college in Savannah. She's dealing with a lot of family turmoil: her father died over a year ago, her brother found out he was a father (and shortly thereafter became a husband), and her mother remarried a long-time family friend. Meghan feels like she's the only one without a plan for her life, which leads to her volunteering as an art teacher in a small town where the art program has been cut.
She met Sam under less-than-ideal circumstances, and when they're thrown together over the summer, neither of them is particularly happy. Sam is a totally serious, responsible guy. . .some might even call him a little uptight. He lost his parents when he was eighteen, and he had to carry a heavy load of responsibility. Sam sees Meghan as a flighty party girl, and he's not shy about letting her know how he feels. Or. . .is that really how he feels?
Q: How did you choose the names for your characters?
A: Most of the time, characters' names simply come with them. Meghan was already named from her appearance in THE POSSE. Sam's name came from a Civil War general, Samuel Cooper, who was the highest ranking Confederate general. Although our Sam's name is Samuel Pierce Reynolds, after his fictional great-great-great-grandfather, I thought of General Cooper as I wrote Sam.
Another little note on names: I almost always include some nod to friends or family or readers in my books. In THE LAST ONE, Meghan's best friend and roommate is Laura, and her boyfriend, a Marine, is Brian. Brian is named after the husband of my very dear friend who retired from the Corps a few years ago. I would have used my friend's name, too, but I know she doesn't love her name. . .and she does love Laura Ingalls Wilder. . .so I gave her Laura's name instead. Got that?
Q: Do you set a certain number of hours to write each day?
A: Up until recently, I have not. My life has been a little haphazard the last few years. I have four children, and although they're mostly grown, they still require attention and time. My youngest is still being homeschooled. And until this past summer, we also cared for a sweet four-year old little boy several days a week. So writing came whenever I could spare a few minutes to sit down.
Now, however, I am in a routine. I write every day from 8-12, and then after lunch, I work on social media, promotion, answering email, checking on my son's school work and I even try to get a work-out in. I will often write more in the afternoon and after dinner, too, if I can.
Q: There are two more books in The One Trilogy. Will we see more of Sam and Meghan?
A: Sam and Meghan will definitely be around, but they won't be the main characters or the persons whose POV we follow. THE FIRST ONE, which is the next book, is about Ali, Sam's sister, and Flynn, her high school boyfriend. Sparks are going to fly when Flynn comes back to town eight years after he left Ali there. But since Ali lives in the same house with Sam, and Meghan is spending a good deal of time there now, too, we'll definitely keep our eye on that relationship, too.
THE ONLY ONE is about Rilla and Mason. We haven't met Rilla yet, and we haven't met Mason by name, though we have seen him. And something special will be happening for Meghan and Sam in that book. Stay tuned.
Tawdra Kandle writes romance, in just about all its forms. She loves unlikely pairings, strong women, sexy guys, hot love scenes and just enough conflict to make it interesting. Her books run from YA paranormal romance (THE KING SERIES), through NA paranormal and contemporary romance (THE SERENDIPITY DUET, PERFECT DISH DUO, THE ONE TRILOGY) to adult contemporary and paramystery romance (CRYSTAL COVE BOOKS and RECIPE FOR DEATH SERIES). She lives in central Florida with a husband, kids, sweet pup and too many cats. And yeah, she rocks purple hair.
Blitz-wide giveaway (INTL):
A $50 gift card to Amazon or BN
I love a good love story and The Last One sounds great.


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It has been quite an interesting summer in the Big Oak Flat/Groveland Unified School District and we are just about ready for the 2016-17 school year. We have hired several new employees, done quite a bit of work at the school sites and finalized our new website. Some of you are probably wishing for more summer time, and some of you are undoubtedly anxious for school to start. Those of us working in the district are ready to go!
New Website – We are very excited to be able to open our new website to our district and community just prior to the opening of school. We knew it was time to update our website and we believe you will like the new features we have included.
Cafeteria – Our cafeteria staff is dedicated to make sure they make, "healthy meals our students will enjoy". We want to be sure our students are looking forward to what is being made in the cafeteria each day, and want to be sure everyone who qualifies and signs up, eats at school every day. Last year we saw many students bringing unhealthy lunches to school, and some students not eating lunch at all. This is unacceptable, and with the national nutrition standards our staff follows, our lunches are super healthy.
Tenaya – Attend one of the two new and required registration nights provided at the school cafeteria on Monday, August 15 and Thursday, August 18 from 4-7pm. You will fill out paperwork and get signed up for the appropriate programs. Pick up paperwork in the school office on August 11th or 12th. For questions, call 962-7846.
Tioga High – Call the school office the week of August 15th to schedule an appointment for Thursday, August 18 or Friday, August 18 to get your schedule of classes. Call 962-4763.
Don Pedro High — Call the school office the week of August 15th to schedule an appointment for Wednesday, August 17th or Thursday, August 18th to get your schedule of classes. Call 852-2864. Come in and meet the new principal, Mr. Rob Egger.
Best wishes for a great school year for your son and/or daughter. I'll see you at school.