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Plaque: Charles Lamb - 89 Chase Side
Charles Lamb lived here October 1829 until May 1833.
Site: Charles Lamb - Chase Side (2 memorials)
EN2, Chase Side, 85 and 89
Number 89 is the house with the white porch on the left of the photograph, and number 85 is the white house with the green door.
Hidden London says: "In September 1827 the essayist and poet Charles Lamb and his sister Mary came to live at the Poplars, Chase Side. The following month they moved to the house next door, lodging with the Westwood family for six years, after which they moved to Church Street, Lower Edmonton." So the duration at Poplars, no 85, is a bit in doubt: one month or two years.
Charles Lamb - 89 Chase Side
Born at 2 Crown Office Row, Inner Temple. Studied at Christ's Hospital where ...
This section lists the other memorials at the same location as the memorial on this page:
Information Also at this site
The overflow pipe is not part of the memorial.
The Bee Gees, Barry, Robin & Maurice Gibb, composed and stayed here, 1968...
Dovehouse Green - Victorian plaque
We think this plaque was probably erected in 1882 when the land was repurpose...
Florence Nightingale - South Street
London County CouncilIn a house on this site Florence Nightingale, 1820 - 191...
Isabella Beeton - Hatch End
The site of 2 Chandos Villas, home of cookery writer Isabella Beeton and her ...
The Trafalgar Way - Brentford
If the erection date of September 2009 is correct, it seems rather strange to...

redpajama_set_name: RedPajamaCommonCrawl


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11 Plain Language Summary
0 Expert Review
11 Full text available
11 Free full text available
11 Journal Article
11 Research Support, N.I.H., Extramural
BANT Guidelines
Equivalence Trial
Digital cognitive behavioral therapy for insomnia promotes later health resilience during the coronavirus disease 19 (COVID-19) pandemic.
Sleep. 2021;44(4)
The Impact of COVID-19 Stay-At-Home Orders on Health Behaviors in Adults.
Obesity (Silver Spring, Md.). 2021;29(2):438-445
Prevalence of Depression Symptoms in US Adults Before and During the COVID-19 Pandemic.
JAMA network open. 2020;3(9):e2019686
Results for 'Covid-19' • 11 results
1. Digital cognitive behavioral therapy for insomnia promotes later health resilience during the coronavirus disease 19 (COVID-19) pandemic.
Cheng, P, Casement, MD, Kalmbach, DA, Castelan, AC, Drake, CL
The 2019 coronavirus disease (COVID-19) pandemic has had health consequences that extend well-beyond symptoms of the virus. Mental health problems are already being observed in the context of COVID-19 and have also been documented during previous epidemics. The aim of this study was to evaluate the effect of prior digital cognitive-behavioural therapy for insomnia (dCBT-I) versus sleep education on health resilience during the COVID-19 pandemic. This study is a follow up study based on a previous randomised controlled trial [SPREAD trial] for which the enrolled participants were divided into two groups: 358 in the dCBT-I condition and 300 in the control condition. For this follow-up study 208 participants (dCBT-I: n = 102; control: n = 106) out of the total 658 participants were enrolled. Results indicate that 67.3% of the sample reported direct impact from the coronavirus, and 26.4% reported living alone during the shelter-in-place orders. Furthermore, those who received dCBT-I reported less insomnia, stress, depression, and better global physical health compared to those who received a sleep education control. Authors conclude that future research should examine the mechanisms by which insomnia treatment may enhance resilience, and the role of dCBT-I in mitigating the adverse health consequences of the COVID-19 pandemic.
STUDY OBJECTIVES Stressful life events contribute to insomnia, psychosocial functioning, and illness. Though individuals with a history of insomnia may be especially vulnerable during stressful life events, risk may be mitigated by prior intervention. This study evaluated the effect of prior digital cognitive-behavioral therapy for insomnia (dCBT-I) versus sleep education on health resilience during the COVID-19 pandemic. METHODS COVID impact, insomnia, general- and COVID-related stress, depression, and global health were assessed in April 2020 in adults with a history of insomnia who completed a randomized controlled trial of dCBT-I (n = 102) versus sleep education control (n = 106) in 2016-2017. Regression analyses were used to evaluate the effect of intervention conditions on subsequent stress and health during the pandemic. RESULTS Insomnia symptoms were significantly associated with COVID-19 related disruptions, and those who previously received dCBT-I reported less insomnia symptoms, less general stress and COVID-related cognitive intrusions, less depression, and better global health than those who received sleep education. Moreover, the odds for resurgent insomnia was 51% lower in the dCBT-I versus control condition. Similarly, odds of moderate to severe depression during COVID-19 was 57% lower in the dCBT-I condition. CONCLUSIONS Those who received dCBT-I had increased health resilience during the COVID-19 pandemic in adults with a history of insomnia and ongoing mild to moderate mental health symptoms. These data provide evidence that dCBT-I is a powerful tool to promote mental and physical health during stressors, including the COVID-19 pandemic. CLINICAL TRIAL REGISTRATION NCT02988375.
Silverchair Information Systems
2. The Impact of COVID-19 Stay-At-Home Orders on Health Behaviors in Adults.
Flanagan, EW, Beyl, RA, Fearnbach, SN, Altazan, AD, Martin, CK, Redman, LM
In response to the global outbreak of COVID-19, a wave of quarantine and stay-at-home mandates were issued to attenuate the rapid worldwide spread. The aim of this study was to quantify changes in habitual dietary behaviours, physical activity, sleep, sedentary behaviours, and mental health before and during the initial peak of the COVID-19 pandemic. This study is based on an anonymous survey via paid advertisements on the social media platform Facebook. A total of 7,753 completed the first COVID-19 question and were thus included in the analysis. Results indicate that: - declines in healthful eating behaviours were coincident with reductions in physical activity. These negative behaviours were characteristic of individuals reporting weight gain in response to the pandemic outbreak. - anxiety scores nearly doubled in response to the pandemic and 20% of the sample reported that symptoms were severe enough to interfere with daily routines. - home confinement led to shifts in daily work and household responsibilities which resulted in mental health declines alongside some positive and many negative changes to health behaviours. Authors conclude that with increased cases of weight gain and significant declines to mental health, COVID-19 may impact clinical practice for years to come.
OBJECTIVE Stay-at-home orders in response to the coronavirus disease 2019 (COVID-19) pandemic have forced abrupt changes to daily routines. This study assessed lifestyle changes across different BMI classifications in response to the global pandemic. METHODS The online survey targeting adults was distributed in April 2020 and collected information on dietary behaviors, physical activity, and mental health. All questions were presented as "before" and "since" the COVID-19 pandemic. RESULTS In total, 7,753 participants were included; 32.2% of the sample were individuals with normal weight, 32.1% had overweight, and 34.0% had obesity. During the pandemic, overall scores for healthy eating increased (P < 0.001), owing to less eating out and increased cooking (P < 0.001). Sedentary leisure behaviors increased, while time spent in physical activity (absolute time and intensity adjusted) declined (P < 0.001). Anxiety scores increased 8.78 ± 0.21 during the pandemic, and the magnitude of increase was significantly greater in people with obesity (P ≤ 0.01). Weight gain was reported in 27.5% of the total sample compared with 33.4% in participants with obesity. CONCLUSIONS The COVID-19 pandemic has produced significant health effects, well beyond the virus itself. Government mandates together with fear of contracting the virus have significantly impacted lifestyle behaviors alongside declines in mental health. These deleterious impacts have disproportionally affected individuals with obesity.
3. Prevalence of Depression Symptoms in US Adults Before and During the COVID-19 Pandemic.
Ettman, CK, Abdalla, SM, Cohen, GH, Sampson, L, Vivier, PM, Galea, S
Coronavirus disease 2019 (COVID-19) is an event that can cause physical, emotional, and psychological harm. Thus, the COVID-19 pandemic can itself be considered a traumatic event. The aim of this study was to (a) assess the burden of depression symptoms in the US during COVID-19 using the same measures deployed in representative national surveys before COVID-19 began, and (b) understand the factors associated with depression symptoms during and before COVID-19. This study is a population-representative survey study of US adults. A total of 1441 participants were included in the final sample out of which 619 participants were aged between 18 and 39 years, 723 were men, and 933 were non-Hispanic White. Results showed that: - prevalence of depression symptoms in the US increased more than 3-fold during the COVID-19 pandemic, from 8.5% before COVID-19 to 27.8% during COVID-19. - there was a shift in depression symptoms, with fewer people with no symptoms and more people with more symptoms during COVID-19 than before COVID-19. - lower income groups were at greater risk of depression symptoms than higher income groups. Authors conclude that the potential for the mental health consequences of COVID-19 to be large in scale, to recognize that these effects can be long-lasting, and to consider preventative action to help mitigate its effects.
Importance: The coronavirus disease 2019 (COVID-19) pandemic and the policies to contain it have been a near ubiquitous exposure in the US with unknown effects on depression symptoms. Objective: To estimate the prevalence of and risk factors associated with depression symptoms among US adults during vs before the COVID-19 pandemic. Design, Setting, and Participants: This nationally representative survey study used 2 population-based surveys of US adults aged 18 or older. During COVID-19, estimates were derived from the COVID-19 and Life Stressors Impact on Mental Health and Well-being study, conducted from March 31, 2020, to April 13, 2020. Before COVID-19 estimates were derived from the National Health and Nutrition Examination Survey, conducted from 2017 to 2018. Data were analyzed from April 15 to 20, 2020. Exposures: The COVID-19 pandemic and outcomes associated with the measures to mitigate it. Main Outcomes and Measures: Depression symptoms, defined using the Patient Health Questionnaire-9 cutoff of 10 or higher. Categories of depression symptoms were defined as none (score, 0-4), mild (score, 5-9), moderate (score, 10-14), moderately severe (score, 15-19), and severe (score, ≥20). Results: A total of 1470 participants completed the COVID-19 and Life Stressors Impact on Mental Health and Well-being survey (completion rate, 64.3%), and after removing those with missing data, the final during-COVID-19 sample included 1441 participants (619 participants [43.0%] aged 18-39 years; 723 [50.2%] men; 933 [64.7%] non-Hispanic White). The pre-COVID-19 sample included 5065 participants (1704 participants [37.8%] aged 18-39 years; 2588 [51.4%] women; 1790 [62.9%] non-Hispanic White). Depression symptom prevalence was higher in every category during COVID-19 compared with before (mild: 24.6% [95% CI, 21.8%-27.7%] vs 16.2% [95% CI, 15.1%-17.4%]; moderate: 14.8% [95% CI, 12.6%-17.4%] vs 5.7% [95% CI, 4.8%-6.9%]; moderately severe: 7.9% [95% CI, 6.3%-9.8%] vs 2.1% [95% CI, 1.6%-2.8%]; severe: 5.1% [95% CI, 3.8%-6.9%] vs 0.7% [95% CI, 0.5%-0.9%]). Higher risk of depression symptoms during COVID-19 was associated with having lower income (odds ratio, 2.37 [95% CI, 1.26-4.43]), having less than $5000 in savings (odds ratio, 1.52 [95% CI, 1.02-2.26]), and exposure to more stressors (odds ratio, 3.05 [95% CI, 1.95-4.77]). Conclusions and Relevance: These findings suggest that prevalence of depression symptoms in the US was more than 3-fold higher during COVID-19 compared with before the COVID-19 pandemic. Individuals with lower social resources, lower economic resources, and greater exposure to stressors (eg, job loss) reported a greater burden of depression symptoms. Post-COVID-19 plans should account for the probable increase in mental illness to come, particularly among at-risk populations.
4. Can Vitamin D and L-Cysteine Co-Supplementation Reduce 25(OH)-Vitamin D Deficiency and the Mortality Associated with COVID-19 in African Americans?
Jain, SK, Parsanathan, R
Journal of the American College of Nutrition. 2020;39(8):694-699
African Americans are more susceptible to vitamin D deficiency. In addition they have lower amounts of cellular glutathione (GSH), which is an antioxidant produced in the body from L-cysteine, capable of affecting genes involved in vitamin D production. Clinical trials have indicated a relationship between vitamin D deficiency and poorer outcomes in patients with COVID-19. This review paper looked at data in humans, animal models and at the cellular level and proposed that African Americans are susceptible to vitamin D deficiency due to increased skin pigmentation affecting its production. Reduced GSH was attributed to decreased dietary intake of L-cysteine, and lower levels of biological compounds, which are involved in the production of GSH. Research surrounding vitamin D's role in immunity and lowering viral infection risk was reviewed and several routes were proposed, such as increasing anti-microbial action, decreasing inflammation, increasing anti-oxidants and blocking viruses entering cells. It was concluded that randomised control trials on vitamin D supplementation have been underwhelming. This disconnect with trials showing a relationship between low vitamin D levels and poor clinical outcomes is due to the fact that vitamin D was tested in isolation. More randomised control trials are needed to investigate co-supplementation with L-cysteine on outcomes of COVID-19 infection in African Americans. Clinicians could use this review to understand the relationship between vitamin D and L-cysteine and, in lieu of any randomised control trials, as a potential justification for co- supplementation of Vitamin D and L-cysteine in patients with vitamin D deficiency and COVID-19.
Early reports indicate an association between the severity of the COVID-19 infection and the widespread 25-hydroxy vitamin D deficiency known to exist in populations around the world. Vitamin D deficiency is extremely common among African American (AA) communities, where the COVID-19 infection rate is three-fold higher, and the mortality rate nearly six-fold higher, compared with rates in predominantly white communities. COVID-19 infection primarily affects the lungs and airways. Previous reports have linked 25-hydroxy vitamin D deficiency with subclinical interstitial lung disease. AA are at risk for lower cellular glutathione (GSH) levels, and GSH deficiency epigenetically impairs VD biosynthesis pathway genes. Compared with vitamin D alone, co-supplementation of vitamin D and L-cysteine (a GSH precursor) showed a better efficacy in improving levels of GSH and VD-regulatory genes at the cellular/tissue level, increasing 25(OH) vitamin D levels, and reducing inflammation biomarkers in the blood in mice studies. We propose that randomized clinical trials are needed to examine the potential of co-supplementation with anti-inflammatory antioxidants, vitamin D and L-cysteine in correcting the 25(OH)VD deficiency and preventing the 'cytokine storm,' one of the most severe consequences of infection with COVID-19, thereby preventing the adverse clinical effects of COVID-19 infection in the vulnerable AA population.
5. Immediate and long-term consequences of COVID-19 infections for the development of neurological disease.
Heneka, MT, Golenbock, D, Latz, E, Morgan, D, Brown, R
Alzheimer's research & therapy. 2020;12(1):69
Covid-19 may cause brain dysfunction evidenced by symptoms individuals experience once they have contracted the disease. Loss of smell, taste and confusion have all been reported by patients and a number of severe cases have reported incidences of stroke. These are all of concern, as Covid-19 can severely affect the elderly who ordinarily are the most likely to suffer from brain disorders. This small review paper of 27 studies stated that there are four possible ways in which Covid-19 may affect the brain, which put Covid-19 sufferers at an increased risk of long-term brain disorders. This was supported by findings, which showed one third of Covid-19 patients leave hospital with evidence of brain dysfunction. Inflammation was heavily reviewed by the authors as a possible causal factor. It was concluded that patients who survive Covid-19 infection are at an increased risk for developing brain disorders such as Alzheimer's disease, however it was acknowledged that further studies are required. Clinicians could use this study to understand the possible need for both short-term and long-term monitoring of brain function in individuals who have survived Covid-19, especially if they are elderly.
Increasing evidence suggests that infection with Sars-CoV-2 causes neurological deficits in a substantial proportion of affected patients. While these symptoms arise acutely during the course of infection, less is known about the possible long-term consequences for the brain. Severely affected COVID-19 cases experience high levels of proinflammatory cytokines and acute respiratory dysfunction and often require assisted ventilation. All these factors have been suggested to cause cognitive decline. Pathogenetically, this may result from direct negative effects of the immune reaction, acceleration or aggravation of pre-existing cognitive deficits, or de novo induction of a neurodegenerative disease. This article summarizes the current understanding of neurological symptoms of COVID-19 and hypothesizes that affected patients may be at higher risk of developing cognitive decline after overcoming the primary COVID-19 infection. A structured prospective evaluation should analyze the likelihood, time course, and severity of cognitive impairment following the COVID-19 pandemic.
6. Effects of COVID-19 Lockdown on Lifestyle Behaviors in Children with Obesity Living in Verona, Italy: A Longitudinal Study.
Pietrobelli, A, Pecoraro, L, Ferruzzi, A, Heo, M, Faith, M, Zoller, T, Antoniazzi, F, Piacentini, G, Fearnbach, SN, Heymsfield, SB
Obesity (Silver Spring, Md.). 2020;28(8):1382-1385
The coronavirus disease 2019 (COVID-19) pandemic has had far reaching health, social, and economic implications. Among them is the abrupt cessation of school programs for children and adolescents in Italy. The aim of this study was to test the hypothesis that factors contributing to weight gain among children and adolescents with overweight and obesity are exacerbated during a pandemic-associated lockdown. This study is a longitudinal clinical trial which enrolled non-adult participants (n=41) with obesity as controls in the ongoing longitudinal observational OBELIX Study in Verona, Italy. Results indicate that eating, activity, and sleeping behaviours changed in an unfavourable direction just after three weeks into their confinement during the national lockdown. Thus, findings support the hypothesis that lockdown appears to create an unfavourable environment for maintaining healthy lifestyle behaviours Authors conclude that recognition of the lockdown phenomenon is the first step in taking preventive measures.
OBJECTIVE The aim of this study was to test the hypothesis that youths with obesity, when removed from structured school activities and confined to their homes during the coronavirus disease 2019 pandemic, will display unfavorable trends in lifestyle behaviors. METHODS The sample included 41 children and adolescents with obesity participating in a longitudinal observational study located in Verona, Italy. Lifestyle information including diet, activity, and sleep behaviors was collected at baseline and 3 weeks into the national lockdown during which home confinement was mandatory. Changes in outcomes over the two study time points were evaluated for significance using paired t tests. RESULTS There were no changes in reported vegetable intake; fruit intake increased (P = 0.055) during the lockdown. By contrast, potato chip, red meat, and sugary drink intakes increased significantly during the lockdown (P value range, 0.005 to < 0.001). Time spent in sports activities decreased by 2.30 (SD 4.60) h/wk (P = 0.003), and sleep time increased by 0.65 (SD 1.29) h/d (P = 0.003). Screen time increased by 4.85 (SD 2.40) h/d (P < 0.001). CONCLUSIONS Recognizing these adverse collateral effects of the coronavirus disease 2019 pandemic lockdown is critical in avoiding depreciation of weight control efforts among youths afflicted with excess adiposity. Depending on duration, these untoward lockdown effects may have a lasting impact on a child's or adolescent's adult adiposity level.
7. The COVID-19 Pandemic: a Call to Action to Identify and Address Racial and Ethnic Disparities.
Laurencin, CT, McClinton, A
Journal of racial and ethnic health disparities. 2020;7(3):398-402
The severe acute respiratory syndrome coronavirus 2 virus was first identified in late 2019 in Wuhan, China. Various unsubstantiated reports emerged declaring that the genetic constitution of Blacks or even the presence of melanin rendered Blacks immune to the virus. This study is a call of action which reviews preliminary data on race and ethnicity in the peer-reviewed literature for citizens in America affected by COVID-19. Findings demonstrate that communities of colour (Blacks) have a higher rate of infection and death in comparison to their population percentage in the state of Connecticut. However, authors are unable to draw conclusions since race and ethnicity data is missing and the data in this paper is the earliest data available. Therefore, the authors call for action to identify and address racial and ethnic health disparities in the COVID-19 crisis.
The Coronavirus disease 2019 (COVID-19) pandemic has significantly impacted and devastated the world. As the infection spreads, the projected mortality and economic devastation are unprecedented. In particular, racial and ethnic minorities may be at a particular disadvantage as many already assume the status of a marginalized group. Black Americans have a long-standing history of disadvantage and are in a vulnerable position to experience the impact of this crisis and the myth of Black immunity to COVID-19 is detrimental to promoting and maintaining preventative measures. We are the first to present the earliest available data in the peer-reviewed literature on the racial and ethnic distribution of COVID-19-confirmed cases and fatalities in the state of Connecticut. We also seek to explode the myth of Black immunity to the virus. Finally, we call for a National Commission on COVID-19 Racial and Ethnic Health Disparities to further explore and respond to the unique challenges that the crisis presents for Black and Brown communities.
8. Potential Anti-SARS-CoV-2 Therapeutics That Target the Post-Entry Stages of the Viral Life Cycle: A Comprehensive Review.
Al-Horani, RA, Kar, S
Viruses. 2020;12(10)
The covid-19 pandemic has required the identification of therapies to prevent infection and limit severity. A previous paper by the same authors reviewed therapies that block the virus in the early stages of its lifecycle. This very large review of over 300 papers aimed to summarise therapeutics which are aimed at blocking the lifecycle of the virus after it has entered the body's cells. The authors began by reviewing the lifecycle of the covid-19 virus explaining how it enters the body's cells, replicates inside and then is released to infect new cells. Several antivirals, antimalarials and natural products were then reviewed. Of note, Remdesivir is being trialled in covid-19 patients, with mixed results, however, is being recommended in the US for the treatment of hospitalised covid-19 patients with severe disease. Ribavirin, which is being trialled in combination with other antivirals is also showing promising results in shortening hospitalisation times in covid-19 patients. It was concluded that any stage of the covid-19 lifecycle could be a target for therapeutics and combining therapies is likely to be more successful than monotherapy. This paper could be used by health care professionals to understand the most recent therapeutic research for covid-19.
The coronavirus disease-2019 (COVID-19) pandemic continues to challenge health care systems around the world. Scientists and pharmaceutical companies have promptly responded by advancing potential therapeutics into clinical trials at an exponential rate. Initial encouraging results have been realized using remdesivir and dexamethasone. Yet, the research continues so as to identify better clinically relevant therapeutics that act either as prophylactics to prevent the infection or as treatments to limit the severity of COVID-19 and substantially decrease the mortality rate. Previously, we reviewed the potential therapeutics in clinical trials that block the early stage of the viral life cycle. In this review, we summarize potential anti-COVID-19 therapeutics that block/inhibit the post-entry stages of the viral life cycle. The review presents not only the chemical structures and mechanisms of the potential therapeutics under clinical investigation, i.e., listed in clinicaltrials.gov, but it also describes the relevant results of clinical trials. Their anti-inflammatory/immune-modulatory effects are also described. The reviewed therapeutics include small molecules, polypeptides, and monoclonal antibodies. At the molecular level, the therapeutics target viral proteins or processes that facilitate the post-entry stages of the viral infection. Frequent targets are the viral RNA-dependent RNA polymerase (RdRp) and the viral proteases such as papain-like protease (PLpro) and main protease (Mpro). Overall, we aim at presenting up-to-date details of anti-COVID-19 therapeutics so as to catalyze their potential effective use in fighting the pandemic.
9. COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status.
Thomas, T, Stefanoni, D, Reisz, JA, Nemkov, T, Bertolone, L, Francis, RO, Hudson, KE, Zimring, JC, Hansen, KC, Hod, EA, et al
JCI insight. 2020;5(14)
There is increasing urgency for the development of Covid-19 therapies. Treatments preventing infection and decreasing the amount of virus in the body have largely been unsuccessful and so the focus has turned to host biological pathways, which may be altered by Covid-19 infection. This observational study of forty-nine Covid-19 positive and negative individuals aimed to determine alterations in the hosts metabolism. The results showed that Covid-19 infection was associated with disrupted host inflammatory and immune pathways. Markers for kidney dysfunction were also increased alongside raised blood sugar levels and fatty acids in the blood. It was concluded that inflammatory markers may be an indicator for disease severity and a target for Covid-19 therapy. Dietary therapy could be used to target blood fatty acid changes brought about by Covid-19 infection. This study could be used by healthcare professionals to understand that inflammation is increased in Covid-19 patients and in lieu of approved therapies, dietary intervention may be of benefit.
BACKGROUNDReprogramming of host metabolism supports viral pathogenesis by fueling viral proliferation, by providing, for example, free amino acids and fatty acids as building blocks.METHODSTo investigate metabolic effects of SARS-CoV-2 infection, we evaluated serum metabolites of patients with COVID-19 (n = 33; diagnosed by nucleic acid testing), as compared with COVID-19-negative controls (n = 16).RESULTSTargeted and untargeted metabolomics analyses identified altered tryptophan metabolism into the kynurenine pathway, which regulates inflammation and immunity. Indeed, these changes in tryptophan metabolism correlated with interleukin-6 (IL-6) levels. Widespread dysregulation of nitrogen metabolism was also seen in infected patients, with altered levels of most amino acids, along with increased markers of oxidant stress (e.g., methionine sulfoxide, cystine), proteolysis, and renal dysfunction (e.g., creatine, creatinine, polyamines). Increased circulating levels of glucose and free fatty acids were also observed, consistent with altered carbon homeostasis. Interestingly, metabolite levels in these pathways correlated with clinical laboratory markers of inflammation (i.e., IL-6 and C-reactive protein) and renal function (i.e., blood urea nitrogen).CONCLUSIONIn conclusion, this initial observational study identified amino acid and fatty acid metabolism as correlates of COVID-19, providing mechanistic insights, potential markers of clinical severity, and potential therapeutic targets.FUNDINGBoettcher Foundation Webb-Waring Biomedical Research Award; National Institute of General and Medical Sciences, NIH; and National Heart, Lung, and Blood Institute, NIH.
10. Clinical Characteristics and Outcomes of Hospitalized and Critically Ill Children and Adolescents with Coronavirus Disease 2019 at a Tertiary Care Medical Center in New York City.
Chao, JY, Derespina, KR, Herold, BC, Goldman, DL, Aldrich, M, Weingarten, J, Ushay, HM, Cabana, MD, Medar, SS
The Journal of pediatrics. 2020;223:14-19.e2
Epidemiologic studies have consistently demonstrated that children are at lower risk of developing severe symptoms or critical illness compared with adults. The aim of this study was to describe the clinical profiles and risk factors for critical illness in hospitalised children and adolescents with COVID-19. The study is a retrospective review of 67 children aged between 1 month to 21 years with COVID-19 from a single tertiary care children's hospital. Out of the 44 children who tested positive, 33 (72%) were admitted to the general paediatric medical unit and 13 (28%) to the paediatric intensive care unit (PICU). Results showed that patients admitted to the PICU were noted to have more severe symptoms and markers of inflammatory response. The most common symptoms at admission were cough (63%) and fever (60.9%). Of the 13 patients in the PICU, 8 (61.5%) were discharged home, and 4 (30.7%) patients remain hospitalized on ventilatory support at day 14. Authors conclude that their study showed a higher rate of PICU admission per hospitalization (28.2%), which they believe may be a reflection of a variety of social determinants that influence health outcomes.
OBJECTIVE To describe the clinical profiles and risk factors for critical illness in hospitalized children and adolescents with coronavirus disease 2019 (COVID-19). STUDY DESIGN Children 1 month to 21 years of age with COVID-19 from a single tertiary care children's hospital between March 15 and April 13, 2020 were included. Demographic and clinical data were collected. RESULTS In total, 67 children tested positive for COVID-19; 21 (31.3%) were managed as outpatients. Of 46 admitted patients, 33 (72%) were admitted to the general pediatric medical unit and 13 (28%) to the pediatric intensive care unit (PICU). Obesity and asthma were highly prevalent but not significantly associated with PICU admission (P = .99). Admission to the PICU was significantly associated with higher C-reactive protein, procalcitonin, and pro-B type natriuretic peptide levels and platelet counts (P < .05 for all). Patients in the PICU were more likely to require high-flow nasal cannula (P = .0001) and were more likely to have received Remdesivir through compassionate release (P < .05). Severe sepsis and septic shock syndromes were observed in 7 (53.8%) patients in the PICU. Acute respiratory distress syndrome was observed in 10 (77%) PICU patients, 6 of whom (46.2%) required invasive mechanical ventilation for a median of 9 days. Of the 13 patients in the PICU, 8 (61.5%) were discharged home, and 4 (30.7%) patients remain hospitalized on ventilatory support at day 14. One patient died after withdrawal of life-sustaining therapy because of metastatic cancer. CONCLUSIONS We describe a higher than previously recognized rate of severe disease requiring PICU admission in pediatric patients admitted to the hospital with COVID-19.
Elsevier Science


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Northeast Laundry Association (http://nelaundry.org/) is the association in the Northeast representing textile supply and service companies. NELA members provide, clean, and maintain reusable textile products, such as uniforms, sheets, table linen, shop and print towels, floor mats, mops, and other items to businesses in all industries. These industries include light, heavy, and hi-tech manufacturing; healthcare; restaurants; service, retail, construction and transportation industries and institutions.
Promotional Products Association International (http://www.ppai.org) is a membership organization leading the evolving promotional products industry in growth, innovation and success.
Society For Human Resource Management (http://www.shrm.org) is the world's largest association devoted to human resource management. Representing more than 250,000 members in over 140 countries, the Society serves the needs of HR professionals and advances the interests of the HR profession.
Textile Rental Services Association (www.trsa.org) is an international organization representing companies that supply laundered garments, uniforms, linens, floor mats, towels and other products necessary for businesses to operate clean, safe facilities while maintaining an attractive environment and image. TRSA advocates for protecting and expanding the textile services market; conducts research and benchmarking initiatives; and provides industry education via its Textile Services magazine and the annual Clean Show.
Universal-Unilink Purchasing Association (www.universal-unilink.com) represents over 600 independent industrial laundries in the United States and Canada. It is designed to provide consolidated purchasing power to its members in the business of uniforms, textiles, laundries, wearables and promotional products.
Western Textile Services Association (www.wtsa.org) serves the interests of industrial uniform and linen supply textile rental companies, along with their suppliers. With membership of over 200 textile rental plants and 75 supplier companies in the Western United States, WTSA keeps members informed and represented regarding important industry trends and legislative issues.


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Vice Admiral (Ret.) Jeff Wieringa, who as a child wanted to fly jets, went on to work as both an award-winning pilot in the U.S. Navy and at Boeing as a Chief Engineer and Vice President. He credits his success to Pittsburg State.
On Friday, he was recognized as one of three Meritorious Achievement Award winners by the PSU Alumni Association, an award established in 1958. Candidates must have demonstrated substantial professional growth and advancement over an extended period.
"I wasn't a great student, but PSU agreed to take a chance on me," he said of his start here as a freshman.
Wieringa grew up uninterested in school and moved a lot as a child, but became the first college graduate in his family. He thrived in the PSU Physics Department, where small class sizes meant that faculty members made a big impact.
Wieringa earned his bachelor's degree in Physics in 1975. He went on to graduate from U.S. Naval Test Pilot School, became a naval aviator, and as an Attack Squadron 128 trained A-6 Intruder pilot, he completed tours onboard USS Ranger and US Kitty Hawk.
He has flown 65 types of aircraft, with more than 4,000 flight hours and 534 carrier landings. He was selected "Outstanding Naval Aviator United States Pacific Fleet." He also was awarded numerous medals, including the Defense Distinguished Service Medal, Legion of Merit, Meritorious Service Medal, Navy and Marine Corps Commendation Medal, the J.H. Doolittle Award, and the Navy and Marine Corps Achievement Medal.
He served as an aeronautical engineering duty officer on the A-12, Avionics Systems project officer, the Attack X/Attack Fighter X program, and commanded the F/A -18 Program, supporting the first combat deployment of the Super Hornet in Operation Iraqi Freedom. In 2007, he was the first Navy flag officer in more than 30 years to direct the Defense Security Cooperation Agency.
Following his retirement from a 34-year career in the Navy, he worked as the Vice President of Boeing Company in the Global Services and Support business, working on the President's airplane and other programs. He also was the Chief Engineer of Boeing Phantom Works.


text:
/*
 * SignalBase.h
 *
 *  Created on: 2013-3-3
 *      Author: fasiondog
 */

#pragma once
#ifndef SIGNALBASE_H_
#define SIGNALBASE_H_

#include <set>
#include "../../KData.h"
#include "../../utilities/Parameter.h"
#include "../../trade_manage/TradeManager.h"
#include "../../serialization/Datetime_serialization.h"

#if HKU_SUPPORT_SERIALIZATION
#include <boost/serialization/shared_ptr.hpp>
#include <boost/serialization/set.hpp>
#include <boost/serialization/assume_abstract.hpp>
#include <boost/serialization/base_object.hpp>
#endif

namespace hku {

/**
 * 信号指示器基类
 * @ingroup Signal
 */
class HKU_API SignalBase : public enable_shared_from_this<SignalBase> {
    PARAMETER_SUPPORT

public:
    SignalBase();
    SignalBase(const string& name);
    virtual ~SignalBase();

    /**
     * 指定时刻是否可以买入
     * @param datetime 指定时刻
     * @return true 可以买入 | false 不可买入
     */
    bool shouldBuy(const Datetime& datetime) const;

    /**
     * 指定时刻是否可以卖出
     * @param datetime 指定时刻
     * @return true 可以卖出 | false 不可卖出
     */
    bool shouldSell(const Datetime& datetime) const;

    /**
     * 下一时刻是否可以买入,相当于最后时刻是否指示买入
     */
    bool nextTimeShouldBuy() const;

    /**
     * 下一时刻是否可以卖出,相当于最后时刻是否指示卖出
     */
    bool nextTimeShouldSell() const;

    /** 获取所有买入指示日期列表 */
    DatetimeList getBuySignal() const;

    /** 获取所有卖出指示日期列表 */
    DatetimeList getSellSignal() const;

    /**
     * 加入买入信号,在_calculate中调用
     * @param datetime 发生买入信号的日期
     */
    void _addBuySignal(const Datetime& datetime);

    /**
     * 加入卖出信号,在_calculate中调用
     * @param datetime
     */
    void _addSellSignal(const Datetime& datetime);

    /**
     * 指定交易对象,指K线数据
     * @param kdata 指定的交易对象
     */
    void setTO(const KData& kdata);

    /**
     * 获取交易对象
     * @return 交易对象(KData)
     */
    KData getTO() const;

    /** 复位操作 */
    void reset();

    typedef shared_ptr<SignalBase> SignalPtr;
    /** 克隆操作 */
    SignalPtr clone();

    /** 获取名称 */
    string name() const;

    /** 设置名称 */
    void name(const string& name);

    /** 子类复位接口 */
    virtual void _reset() {}

    /** 子类克隆接口 */
    virtual SignalPtr _clone() = 0;

    /** 子类计算接口,在setTO中调用 */
    virtual void _calculate() = 0;

protected:
    string m_name;
    KData m_kdata;
    bool m_hold;

    // 用 set 保存,以便获取是能保持顺序
    std::set<Datetime> m_buySig;
    std::set<Datetime> m_sellSig;

//============================================
// 序列化支持
//============================================
#if HKU_SUPPORT_SERIALIZATION
private:
    friend class boost::serialization::access;
    template <class Archive>
    void save(Archive& ar, const unsigned int version) const {
        ar& BOOST_SERIALIZATION_NVP(m_name);
        ar& BOOST_SERIALIZATION_NVP(m_params);
        ar& BOOST_SERIALIZATION_NVP(m_hold);
        ar& BOOST_SERIALIZATION_NVP(m_buySig);
        ar& BOOST_SERIALIZATION_NVP(m_sellSig);
        // m_kdata都是系统运行时临时设置,不需要序列化
        // ar & BOOST_SERIALIZATION_NVP(m_kdata);
    }

    template <class Archive>
    void load(Archive& ar, const unsigned int version) {
        ar& BOOST_SERIALIZATION_NVP(m_name);
        ar& BOOST_SERIALIZATION_NVP(m_params);
        ar& BOOST_SERIALIZATION_NVP(m_hold);
        ar& BOOST_SERIALIZATION_NVP(m_buySig);
        ar& BOOST_SERIALIZATION_NVP(m_sellSig);
        // m_kdata都是系统运行时临时设置,不需要序列化
        // ar & BOOST_SERIALIZATION_NVP(m_kdata);
    }

    BOOST_SERIALIZATION_SPLIT_MEMBER()
#endif /* HKU_SUPPORT_SERIALIZATION */
};

#if HKU_SUPPORT_SERIALIZATION
BOOST_SERIALIZATION_ASSUME_ABSTRACT(SignalBase)
#endif

#if HKU_SUPPORT_SERIALIZATION
/**
 * 对于没有私有变量的继承子类,可直接使用该宏定义序列化
 * @code
 * class Drived: public SignalBase {
 *     SIGNAL_NO_PRIVATE_MEMBER_SERIALIZATION
 *
 * public:
 *     Drived();
 *     ...
 * };
 * @endcode
 * @ingroup Signal
 */
#define SIGNAL_NO_PRIVATE_MEMBER_SERIALIZATION                \
private:                                                      \
    friend class boost::serialization::access;                \
    template <class Archive>                                  \
    void serialize(Archive& ar, const unsigned int version) { \
        ar& BOOST_SERIALIZATION_BASE_OBJECT_NVP(SignalBase);  \
    }
#else
#define SIGNAL_NO_PRIVATE_MEMBER_SERIALIZATION
#endif

#define SIGNAL_IMP(classname)              \
public:                                    \
    virtual SignalPtr _clone() override {  \
        return SignalPtr(new classname()); \
    }                                      \
    virtual void _calculate() override;

/**
 * 客户程序都应使用该指针类型,操作信号指示器
 * @ingroup Signal
 */
typedef shared_ptr<SignalBase> SignalPtr;
typedef shared_ptr<SignalBase> SGPtr;

HKU_API std::ostream& operator<<(std::ostream&, const SignalBase&);
HKU_API std::ostream& operator<<(std::ostream&, const SignalPtr&);

inline KData SignalBase::getTO() const {
    return m_kdata;
}

inline string SignalBase::name() const {
    return m_name;
}

inline void SignalBase::name(const string& name) {
    m_name = name;
}

inline bool SignalBase::shouldBuy(const Datetime& datetime) const {
    return m_buySig.count(datetime) ? true : false;
}

inline bool SignalBase::shouldSell(const Datetime& datetime) const {
    return m_sellSig.count(datetime) ? true : false;
}

} /* namespace hku */
#endif /* SIGNALBASE_H_ */

redpajama_set_name: RedPajamaGithub


FINE GAEL MEP Seán Kelly has rowed back on his call for Irish people not to visit Mauritius in the wake of the not guilty verdict in the Michaela McAreavey murder trial following the remarks of the Mauritian DPP today.
Kelly, a family friend of the Hartes, said on Facebook yesterday that there had been "no justice" for the Tyrone woman after two men were acquitted of her murder following an eight-week trial and said that "no Irish should visit Mauritius until justice is done".
But following remarks by the Director of Public Prosecutions in Mauritius, Satyajit Boolell, who indicated that there was a 'possibility' of a new trial in the case on RTÉ Radio this morning, Kelly said that if that process was satisfactory for the McAreavey and Harte families he'd reconsider.
He told TheJournal.ie today: "If the process is ongoing and it's genuine then we would have to give that time. But I was afraid that the trial is over, there was no result, and no proof so they would have to drop it.
"Once the McAreavey and Harte families are happy it would change the circumstances certainly," he said adding that there had been "a lot of incredulity regarding the whole process" of the Mauritian judicial system in light of the not guilty verdict.
The former GAA president said there was a danger with the court's verdict that "justice wont be done at all" and said he had been worried that "unless we as a nation stand behind them it would slip away into oblivion".
Of Michaela, who was murdered last year while on honeymoon with her husband John McAreavey, Kelly said that he had met her on number of occasions.
"She was a lovely girl, an exceptionally fine girl in every respect and I just think this is outlandish and I think we have to stand behind them as a nation," he said.
Meanwhile, a spokesman for Enda Kenny has denied that the Taoiseach criticised the judicial system in Mauritius, the Irish Independent reports.
Kenny had said yesterday that justice "clearly hasn't been done" but a spokesperson said that Kenny was merely empathising with the family.
Kelly said the Taoiseach was right to have said what he did, telling TheJournal.ie: "He obviously, like myself, was very unhappy with what happened and obviously was very disappointed for the McAreavey family.
"In fairness they have admitted themselves that the process wasn't maybe as professional as it might have been.
Email "Michaela: FG MEP rows back on call for Irish tourists to boycott Mauritius ".
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The path of universal brotherhood and a just society is not possible unless wahabiyat stops its hidden propaganda and unless the pretext of 'collateral damage' stops working.
A good comment by Hamza sb which has gone unanswered. The irony is that barabaric scholars are hailed as "enlightened" by selectively quoting them. With such hypocrisy, no progress is possible.


text:
Local Bartenders Lead with Sustainable Spirits
8:32 AM UTC on Jul 31, 2020
Have you ever ordered a cocktail, taken a sip, and wondered just how much energy went into making that magical concoction? Centuries of wisdom passed down from bartender to bartender, years of experimentation with nuance and flair converging in 21st-century awareness of profit and, increasingly, sustainability. It could take a thousand thoughtful decisions to make one perfect drink, and nowadays, mixologists are considering sustainability as part of the process. From the bartender to the establishment to the liquor supplier, the alcohol industry, and the big agriculture behind it, the spirits in our glass impact a whole lot more than our happy hour. With over 120 billion pounds of agricultural crops grown for alcohol production annually, how the crops are grown–conventionally or sustainably–marks the first big impact. From grain to glass, the energy and resources necessary to ferment and distill the spirit, the waste generated, the packaging, and transportation all add up to one big carbon footprint. Wouldn't it be just a little sweeter, a touch brighter, a bit more relaxing to know that what is in your glass is not contributing to the warming of the planet, rather your drink is sustainably sourced and ready to be raised to your health and the health of the entire planet.
The good news is, the big liquor industry wants to be sustainable, the craft liquor industry is already doing it, and perhaps most importantly, our favorite neighborhood bartenders have been hard at work building fabulous cocktails with sustainable spirits, fresh ingredients and zero waste. We can only assume the rest of us, from home mixologists to occasional imbibers, will be following their moves before too long. It's no surprise, bartenders have always been skilled persuaders, experts in behavior, scientists of society. In the 19th century, "Professor" Jerry Thomas changed the game by insisting the bartender be viewed as a creative professional, a role he himself aptly played from east to west coast, paving the way for world-renowned mixologists to come. Thomas had a formidable rival in Harry Johnson, who established the first bar management consulting firm after publishing his New and Improved Bartender's Manual, or How to Mix Drinks in the Present Style in 1882. Things have changed a bit since then, but we still enjoy variations of those same recipes from Thomas and Johnson, and we can bet if they were alive today, they'd be experimenting on how to make sustainable cocktails to keep us drinking well into the morning.
Today's bartending pioneers are as near as our neighborhood bar and they're innovating in the spirit of Thomas and Johnson. Not only are they choosing "green" spirits, they're growing their own ingredients, sourcing locally, composting waste, choosing glassware over disposable types, recycling liquor bottles, and concocting not only cocktails, but natural cleaning products to reduce their environmental impact and ultimately fix us all a more sustainable drink. Down in New Orleans at the bar Loa, Alan Walter, aka Spirit Handler, uses fresh, local ingredients that he sometimes forages himself, creating cocktail menus that change with the season. He makes dozens of syrups, tinctures, and aromatic bitters on-site, and when you order a cocktail, it will most certainly arrive in a vintage glass from Walter's own collection.
Meanwhile, in Denver at the world-renowned Death & Co, bar manager Alex Jump reflects on her profession: "From co-workers to guests to everyone in between, there is a beautiful connection created through the sharing of food & drink that is irreplaceable." Just before the COVID shutdown, Death & Co was featuring a drink called the Free Tail, and for every one sold, they'd donate $1 to the Bat Friendly Tequila & Mezcal Project, dedicated to protecting the long-nosed bats that are often agave's number one pollinator. No bats, no tequila. Even more reason to go green. Jump says: "If you're looking for a great tequila to drink at home, Siembra Valles is always going to be my number one recommendation for the sustainability and conservation work they're doing in Mexico."
Sustainability breeds innovation and vice versa. Kristin Koefod, co-founder and COO of 18.21 Bitters, says many of their flavors were born of an attempt at using up excess ingredients. They soak cherries in high-proof whiskey to make their Tart Cherry + Saffron bitters and to avoid wasting the delicious boozy fruit, they started making limited edition Whiskey Soaked Cherry Shrub. Their White Jasmine + Grapefruit Shrub came from hundreds of grapefruits left bald from zesting. Like the way a dash of bitters can change a cocktail, Koefod says using "sustainable spirits is a small and meaningful part in helping the environment." 18.21 Bitters has a new line of carbonated cocktail mixers linked to different non-profits, one of which is focused on beach and water cleanup. "When we owned a bar, we used anything in the kitchen that was about to go bad as a garnish, we only used paper straws, all of those small things are important for the future of our earth."
Bartenders are particularly poised to lead the sustainability movement, with some of them enjoying celebrity status online. Ashley Hupp, a 28-year-old breakout star,Hupp posts on TikTok as @TheParadise.Bartender. She's got the attention of 2.7 million fans who showed up pretty much overnight when Hupp started posting video recipes of herself making drinks against the backdrop of her native Hawaiian coast. In a time of social distancing, her bright persona and positive message have had an especially engaging effect on viewers. Like Jerry Thomas, today's bartenders–including professionals like the Kobricks, Koefed and Hupp–all have a huge opportunity to help us build a better cocktail, and a better future for the world. But at the end of the day, whether you're pouring a beer at a dive bar or stirring martinis until your wrists hurt, sustainability is where we're all heading. Just don't get too fancy with it. You'll end up looking like Tom Cruise.


In this lesson, you'll have a button press modify the value of a variable rather than have the button press directly impact the code. This adds one more link to the chain of code complexity: Button --> Variable --> Action on screen.
This lesson shows that some things that are fairly simple for a human take some work to make happen for a computer. The program doesn't 'know' anything about the character, so you have to very carefully think about and track the different states with code.


This listing is for an extremely rare original vintage AMT Authentic Model Plastic Kit of the original, early 1960's First issue. "1949 Ford Club Coupe" - From the AMT "Trophy Series". This is one Hot Bad to the Bone model kit here modelers! 3 in 1 Customizing Kit - Stock - Custom - Racing Competition. T149 - Another great early model car kit - A sure winner from AMT. Build as Hot Competition for the Track or Strip! AMT Authentic Kit; is accurately scaled, ready to assemble, easy to build, completely formed plastic, ready to paint model kit. This is a 3 in 1 Customizing kit / Build it all Stock, Pro-Racing Drag Competition, or Beautiful Custom Show Car by AMT's own Customizing Team. Customized & styled by the famous "King of Kustomizers" - George Barris sharing all with you to build this car Genuine Custom! AMT's Greatest Customizing Team Ever - to bring you the newest in custom ideas. AMT Custom Consultants George Barris & Car Craft Magazine arm you with the latest ideas & innovations. "Bud Anderson" tells all of his secrets on painting your Hot model with his personal illustrated step-by-step made easy directions! (Painting & Applying Decals Tips). That's some priceless information you'll dig, appreciate, never forget & find valuable for all your future builds modelers!
Kit's loaded with lots of chrome, colorful custom decals, fully detailed assembly instructions/plans & story details of history of this car included inside. USA Made - AMT Corp.
Box 400 - Troy, Michigan. 1/25 scale model kit designed for real car quality, speed assembly. 2 engines, both stock & big block Blown CAD engine, headers, show engine stand, lots of chrome parts, custom accessories, one piece body, detailed chassis, stock hood, hood ornament, custom shaved leaded in hood, hood air scoop, roof scoop, custom wheel discs, stock wheels, stock hub caps, wheel rings, drag Mag wheels, brake drums, soft rubber tires, complete exhaust system, custom pipe extensions, stock & custom grilles, Bumpers, fender skirts, detailed interior, dash board & instruments panel, roll bar cage, bucket seats, safety belts, fire extinguisher, Moon competition fuel tank, competition headlamp lens covers, stock bench seats, detailed undercarriage, "A" frame, steering wheel, floor shifter, shock-absorbers, chrome bumpers, license plate, real clear windows, colorful custom decals, trophy, painting suggestions for a wild paint job & lots, lots more! Included Bonus: Authentic Model Turnpike Official AMT Modelers "License to Drive". Only in AMT model car kits do you get authentic speed equipment from such leading manufactures as.
The stands filled with cheering crowds in the background.... Also some of the many fantastic customizing & racing accessories that are included inside this super kit!!
- "WOW - WOW - WOW". This is truly one Exploding Hot Kit!
It's real because it's AMT! Just like the real car! - "Top quality customizing kit".
This kit is a replica of one of the worlds first early on true Hot Muscle American Detroit built cars of all time. A definite true timeless super-hot classic auto.. This is an extremely very rare hard to find model kit in this "Pristine" time capsule like kept condition, or otherwise at all even.
Rare opportunity presented here to get this kit for yourself now. Don't miss out - This is an amazing collectors Kit. Another original one owner model kit from me personal lifetime well cared for collection offered up here to you. Will make a great collectible addition for you, or as a gift for a special someone you know to add to their own collection. See all listings photos for best description details.
Good feedback is always left prompt once good feedback has been left letting me know you rec'd your model safely first. More being added to my listings offered all the time.... Add me to your "Favorite Sellers" watch list to keep updated. Your business is very appreciated & I always hope to continue doing more on other items in the future with you as well. The item "VTG'49 Ford Club Coupe Model/Kit AMT USA T149 3in1 Pristine Time Capsule Kept" is in sale since Thursday, November 24, 2016. This item is in the category "Toys & Hobbies\Models & Kits\Automotive\Vintage".
The seller is "bebopbeat" and is located in Parsonsfield, Maine. This item can be shipped to United States, to Canada, to United Kingdom, DK, RO, SK, BG, CZ, FI, HU, LV, LT, MT, EE, to Australia, GR, PT, CY, SI, to Japan, to China, SE, KR, ID, to Taiwan, TH, to Belgium, to France, to Hong Kong, to Ireland, to Netherlands, PL, to Spain, to Italy, to Germany, to Austria, RU, IL, to Mexico, to New Zealand, PH, SG, to Switzerland, NO, SA, UA, AE, QA, KW, BH, HR, MY, CL, CO, CR, DO, PA, TT, GT, SV, HN, JM.
Another Amazing AMT 3 in 1 Kit: Customizing Tips & Ideas by George Barris "King"


text:
Home » Popular Streamers Pokimane And Disguised Toast React… To Getting Banned On Twitch
Popular Streamers Pokimane And Disguised Toast React… To Getting Banned On Twitch
Turns out, even the most popular streamers aren't free from the DMCA injunction hammer. In the past week, two high-profile Twitch streamers – Pokimane and Disguised Toast – have been given Twitch bans after streaming popular animated series on their channels. While the reason for these bans has not been officially confirmed by the streaming platform, all signs point to both cases involving copyright infringement – and both streamers have some thoughts.
Lucky for Imane "Pokiman" Anys, who was banned from streaming the Nickelodeon series on Friday, January 7. Avatar: The Last Airbender, her account has already been recovered. Considering Pokimane is one of the site's biggest streamers, with a whopping 8.5 million followers, her quick verdict isn't all that surprising. According to the streamer's tweets, she was denied access to her channel for 48 hours, after which she held a 12-hour stream Monday morning discussing the "fair" and "inevitable" punishment.
just to be clear, I'm not surprised and I don't think this is unfair. imo, it was inevitable that publishers would take action, against me or anyone else, during this comment meta.
will talk more about it Monday, when I can explain the situation further! 💜
— pokimane (@pokimanelol) January 9, 2022
As for Jeremy "Disguided Toast" Wang, the future of his channel is more uncertain, but it looks like you could be waiting a long time before seeing him grace the front page of the site. Banned on Monday, January 10 after streaming the popular anime series Obituary, it looks like the streamer could wait up to a month to restore his channel — something that both Toast and his fellow streamers seem a little shattered about. Toast addressed the ban on Twitter, writing "Poeper, looks like I'll be seeing you in a month" to his 1.5 million followers.
well, looks like i'll be seeing you in a month
— Toast (@DisguidToast) January 11, 2022
Shortly after his tweet, streamers Ludwig, Hasanabi, Hafu, Bnans, Peter Park and several others expressed surprise at the long sentence. While Pokimane may have thought her ban was fair, many have questioned the length of Toast's sentence, which seems grueling in comparison. However, Twitter user Petr Fogl was quick to point out that Toast is apparently "100+ episodes" of Obituary on his channel, which could contribute to the month-long ban.
It's really not, he's watched over 100 episodes. He's lucky it isn't anymore.
— Petr Fogl (@PetrFogl) January 11, 2022
Unfortunately for Twitch streamers who participate in what's now called the "TV meta" – a new trend that some streamers are jumping on where they try to attract more viewers to their channel by streaming popular shows – this is the danger that comes with it. with the territory. In recent years, the streaming service has been notoriously tough on DMCA violations, eventually implementing a three-warning policy that could result in a streamer's channel being removed.
While some have discussed the seriousness of Twitch's enforcement, expressing frustration at how justice is distributed unevenly depending on a streamer's popularity, at this point it appears that the platform isn't ready to release their DMCA rights. forbidden to solve quickly. . With such glaring bans, it seems likely that more streamers will shy away from such a risky, high-reward method of growing their channel, though time will tell.
Disney Gargoyles: Awakening Board Game Review
How Much Dying Light 2 Is Too Much? – Unlocked 526
Logitech's Pen is a durable stylus made for...


PETA has issued new guidelines for helping people remove what it has dubbed "speciesism" and anti-animal language from daily conversations.
"Words matter, and as our understanding of social justice evolves, our language evolves along with it," reads a tweet on the official PETA Twitter account.
An accompanying chart gives several examples of common terms that PETA has dubbed offensive to animals alongside handy replacement phrases.
Time will tell if these new PETA approved phrases will take off, but there's good news for early adopters, as we all know the early bird has brunch with the worm.
Topics: animal, Animal Abuse, language, PETA, phrase.


text:
NewsPaperthe art of publishing
Home BETTING TIPS Bwin Plans To Reach The Colombian Market In 2021
Bwin Plans To Reach The Colombian Market In 2021
By Gamble Geeks
The Entain Plc group, formerly GVC Holdings and owner of gaming operator Bwin, has advanced the company's intentions to continue expanding in South America. The next regulated market that the company could access in the short term would be Colombia, with the possibility that its flagship brand Bwin will break into the market next month.
Martin Lycka, Senior Vice President of Regulatory Affairs and Responsible Gambling for the United States at Entain Plc, discussed the rapid progress of the FTSE100 betting group in Colombia after obtaining the license from the regular body in Colombia, Coljuegos.
Bwin Could Be In Colombia In January 2021
Marin Lycka confirmed that the company would force to enter Colombia as soon as possible, with early 2021 being the scheduled date.
Colombia has had a regulated gambling market since 2017 in a similar way to what happens, for example, in Spain, where a state-dependent body is responsible for granting licenses and controlling everything that concerns gambling.
Bwin Could Be The 1st Global Operator To Operate In Colombia
Lycka stated that Bwin would be the first truly global operator to operate in Colombia since although Spanish brands are already working, they are part of companies that are present in only a few countries. But it is that Bwin is an international operator with an almost worldwide reach.
After the change from Holdings to Entain, Colombia has been the next destination to be conquered for the company. The objective is for the business in the coffee country to be of a large volume and to become the safest online gambling option in the country.
Brazil Is Also Part Of Bwin's Plans
But Colombia is not the only country in the region that would be in Entain's orbit, since the company would be monitoring the development of markets in other Latin American countries, within the new expansion strategy.
Possibly the arrival in Brazil would be part of Bwin's plans for 2021.
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Targeting R&D intensity in Finnish innovation policy
Matthias Deschryvere, Kai Husso, Arho Suominen
Quantitative science and technology studies
Finland has been setting research and development (R&D) intensity targets for almost 50 years. This paper explores the Finnish national policy experience in fostering public and private investments in R&D. Three key insights are the following: a) a systemic and integrated policy approach needs an impactful co-ordination and governance mechanism; b) a balanced innovation system with well-working joint public-private partnership efforts and mechanisms will do better in absorbing shocks; c) a key strategy to absorb shocks to the economy and society is to invest in long-term capabilities. This study also provides an overview of the factors influencing the level of R&D intensity. The current 4% target to be reached by 2030 was set in 2019 but thus far relatively few policy actions have been introduced to operationalise it. With these dynamics and uncertainty, it remains to be seen if the target will be reached by 2030.
D4 Published development or research report or study
R&D policies for better post-pandemic futures: New approaches and tools. - Virtual event, Helsinki, Finland
Duration: 20 May 2021 → 21 May 2021
https://www.vttresearch.com/en/news-and-ideas/virtual-event-rd-policies-better-post-pandemic-futures-new-approaches-and-tools
OECD Science, Technology and Industry Working Papers
R&D intensity targets
R&D policy
Dive into the research topics of 'Targeting R&D intensity in Finnish innovation policy'. Together they form a unique fingerprint.
Innovation Policy Business & Economics 100%
Targeting Business & Economics 83%
Coordination Mechanism Business & Economics 35%
Governance Mechanisms Business & Economics 33%
Public Investment Business & Economics 33%
Private Investment Business & Economics 33%
Finland Business & Economics 32%
Innovation System Business & Economics 32%
Deschryvere, M., Husso, K., & Suominen, A. (2021). Targeting R&D intensity in Finnish innovation policy. OECD. OECD Science, Technology and Industry Working Papers No. 2021/08 https://doi.org/10.1787/18151965
Deschryvere, Matthias ; Husso, Kai ; Suominen, Arho. / Targeting R&D intensity in Finnish innovation policy. Paris : OECD, 2021. 44 p. (OECD Science, Technology and Industry Working Papers; No. 2021/08).
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title = "Targeting R&D intensity in Finnish innovation policy",
abstract = "Finland has been setting research and development (R&D) intensity targets for almost 50 years. This paper explores the Finnish national policy experience in fostering public and private investments in R&D. Three key insights are the following: a) a systemic and integrated policy approach needs an impactful co-ordination and governance mechanism; b) a balanced innovation system with well-working joint public-private partnership efforts and mechanisms will do better in absorbing shocks; c) a key strategy to absorb shocks to the economy and society is to invest in long-term capabilities. This study also provides an overview of the factors influencing the level of R&D intensity. The current 4% target to be reached by 2030 was set in 2019 but thus far relatively few policy actions have been introduced to operationalise it. With these dynamics and uncertainty, it remains to be seen if the target will be reached by 2030.",
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author = "Matthias Deschryvere and Kai Husso and Arho Suominen",
doi = "https://doi.org/10.1787/18151965",
series = "OECD Science, Technology and Industry Working Papers",
publisher = "OECD",
number = "2021/08",
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note = "R&D policies for better post-pandemic futures: New approaches and tools. ; Conference date: 20-05-2021 Through 21-05-2021",
url = "https://www.vttresearch.com/en/news-and-ideas/virtual-event-rd-policies-better-post-pandemic-futures-new-approaches-and-tools",
Deschryvere, M, Husso, K & Suominen, A 2021, Targeting R&D intensity in Finnish innovation policy. OECD Science, Technology and Industry Working Papers, no. 2021/08, OECD, Paris. https://doi.org/10.1787/18151965
Targeting R&D intensity in Finnish innovation policy. / Deschryvere, Matthias; Husso, Kai; Suominen, Arho.
Paris : OECD, 2021. 44 p. (OECD Science, Technology and Industry Working Papers; No. 2021/08).
T1 - Targeting R&D intensity in Finnish innovation policy
AU - Deschryvere, Matthias
AU - Husso, Kai
AU - Suominen, Arho
N2 - Finland has been setting research and development (R&D) intensity targets for almost 50 years. This paper explores the Finnish national policy experience in fostering public and private investments in R&D. Three key insights are the following: a) a systemic and integrated policy approach needs an impactful co-ordination and governance mechanism; b) a balanced innovation system with well-working joint public-private partnership efforts and mechanisms will do better in absorbing shocks; c) a key strategy to absorb shocks to the economy and society is to invest in long-term capabilities. This study also provides an overview of the factors influencing the level of R&D intensity. The current 4% target to be reached by 2030 was set in 2019 but thus far relatively few policy actions have been introduced to operationalise it. With these dynamics and uncertainty, it remains to be seen if the target will be reached by 2030.
AB - Finland has been setting research and development (R&D) intensity targets for almost 50 years. This paper explores the Finnish national policy experience in fostering public and private investments in R&D. Three key insights are the following: a) a systemic and integrated policy approach needs an impactful co-ordination and governance mechanism; b) a balanced innovation system with well-working joint public-private partnership efforts and mechanisms will do better in absorbing shocks; c) a key strategy to absorb shocks to the economy and society is to invest in long-term capabilities. This study also provides an overview of the factors influencing the level of R&D intensity. The current 4% target to be reached by 2030 was set in 2019 but thus far relatively few policy actions have been introduced to operationalise it. With these dynamics and uncertainty, it remains to be seen if the target will be reached by 2030.
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KW - Finland
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BT - Targeting R&D intensity in Finnish innovation policy
PB - OECD
CY - Paris
T2 - R&D policies for better post-pandemic futures: New approaches and tools.
Deschryvere M, Husso K, Suominen A. Targeting R&D intensity in Finnish innovation policy. Paris: OECD, 2021. 44 p. (OECD Science, Technology and Industry Working Papers; No. 2021/08). https://doi.org/10.1787/18151965


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4th Estate
ACC Editions
André Deutsch
Birlinn
Carpet Bombing Culture
Crown Archetype
Dey St
Ebury
John Blake
Little, Brown
Little, Brown and Co
Methuen Drama
Painted Turtle
Reel Art
Sidgwick & Jackson
Skyhorse
Weidenfeld
Filtered to: bicdescription Individual actors & performers bicdescription
More Than Just A Good Life
The Authorised Biography of Richard Briers
Hollywood's Last Icon
Marc Eliot
The Definitive Biography
One of the most charismatic actors of his generation, Peter O'Toole (1932–2013) brought a dangerous edge to both his roles and his life. Drawing on exclusive interviews with colleagues and friends, this biography from the author of Hellraisers paints an intimate picture of a complex, much-loved man. From the mystery of his place of birth through his formative years with the Royal Shakespeare Company, the book charts his celebrated performances, his turbulent relationships and his drunken antics.
Martin Freeman: From Slough to Middle Earth
Nick Johnstone
The Moment an Actress Becomes an Icon
George Tiffin
My Life as a Beach Boy
Mike Love;James S Hirsch
A Brief Life
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An Actors Despairs
There's Something I've Been Dying to Tell You
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Twentieth-Century Star
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Morecambe & Wise
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My Fifty-Year Friendship with a Remarkable Man
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Audrey and Bill
A Romantic Biography of Audrey Hepburn and William Holden
Edward Z Epstein
Audrey Hepburn and William Holden met on the set of Sabrina in 1954 and began a sensational love affair that, although it was short-lived, marked a turning point in both their lives. This double biography reveals the workings of Hollywood in the 1950s and 1960s, charting the rise to fame of the two stars and following their subsequent careers and private lives beyond the pivotal affair.
Michael Caine:
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The Marilyn Encyclopedia
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Kate Remembered
Katharine Hepburn: A Personal Biography
A Scott Berg
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Despite the success of American Graffiti in 1973, George Lucas was unable to get the rights to Flash Gordon, so instead began to develop his own science fiction soap opera. Tracing the director's roots and influences, this biography recounts the stories of bringing blockbusters such as Star Wars to the screen and assesses Lucas's profound influence on movie-making, not least through the foundation of special effects and production companies such as Pixar and THX Sound.
Movie Star Italian Style
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Kendra Bean;Anthony Uzarowski
Dismissive of her own talent and largely remembered for her off-screen antics, this lavishly illustrated biography of Ava Gardner aims to set the record straight. Charting four decades of film history, the authors examine Gardner's roles in movies such as The Killers and Night of the Iguana, the creation of her image, her tempestuous relationships (including with Hemingway and Sinatra) and her loyal friendships, revealing her to be far more than an MGM-created 'cookie-cutter star'. Slightly off-mint.
Great Historical Shakespeare Recordings
This collection brings to life the greatest Shakespearian performances of the 19th and 20th centuries, from Irving's Richard III and Terry's Ophelia to Gielgud's Romeo and Olivier's Henry V. The second disc's miscellany includes Edith Evans as Lady Bracknell and a dialogue by Laurel and Hardy.
The Death of Photography
Peter Gravelle
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No Cunning Plan
After stints in regional theatre in Leeds, Birmingham and Bristol, Tony Robinson played small parts on television during the 1970s, including presenting Play Away, and began to make his name as a comedian in the early 1980s with the sketch show Who Dares Wins. The Blackadder star reads his engaging autobiography in this 12-CD set.
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Dead Now Of Course
Phyllida Law
Greasepaint, sausage pie in the landlady's Aga, alcoholic monkeys, Peter Wyngarde's wig on fire... Phyllida Law gives a hugely entertaining account of her early acting career and her marriage to Eric Thompson.
Before Marilyn
The Blue Book Modelling Years
Astrid Franse;Michelle Morgan
Miss Emmeline Snively, head of the Blue Book Agency, nurtured 19-year-old Norma Jeane Dougherty at the beginning of the young woman's modelling career, before she transformed into the movie icon Marilyn Monroe. It was Miss Snively's archive, which includes previously unseen colour and black-and-white photographs, adverts, notes and press clippings from the agency, which enabled the authors to put together this unique and detailed account of Marilyn's first tentative steps along the road to fame.
Philip Norman
Philip Norman's history of the Beatles, Shout!, and his biography of John Lennon seemed to take a largely anti-McCartney stance so it was a surprise when Paul gave tacit approval to Norman to write this biography, enabling access to family members and close friends. The result redresses the balance, describing the importance of McCartney's creative leadership in the Beatles and exploring his later career and personal life from the early death of his mother to his highly publicized marriages. Felt-tip mark on upper trimmed edge.
I Know Nothing!
The Autobiography
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Much loved as the Spanish waiter Manuel in Fawlty Towers, Andrew Sachs (1930-2016) was born in Berlin rather than Barcelona and fled to England in 1938 after his father was arrested by the Gestapo. In this compelling and often hilarious memoir he tells of his early years in showbiz, the success of the infamous Torquay hotel, and his acting career beyond Fawlty, which included Shakespeare, Dustin Hoffman's Quartet, a stint as Father Brown, and Snowy in BBC Radio 5's Tintin.
Reflections on a Legendary Life
Manoah Bowman;Natasha Gregson Wagner et al
Natalie Wood's roles in Rebel Without a Cause and The Searchers in the mid 1950s made her an international star before the age of 18. Oscar-nominated performances in later films and a high-profile marriage to Robert Wagner kept her in the news until her mysterious death in 1981. This large-format photographic celebration contains stills, promotional shots and on-set and behind-the-scenes images from all her movies, as well as snaps from her private family collection. Felt-tip mark on lower trimmed edge.
Over the Top and Back
Achieving phenomenal success in America in the 1960s and 1970s, Tom Jones's image as a hairy-chested Vegas superstar contributed to his becoming deeply unfashionable by the 1980s, but his resilience and vocal ability saw him come back strongly after teaming up with the Art of Noise to cover Prince's Kiss in 1988. In this autobiography he discusses his childhood, teenage marriage and early struggles as well as the highs and lows of his showbiz career. Felt-tip mark on lower trimmed edge.
One of the most charismatic actors of his generation, Peter O'Toole (1932-2013) brought a dangerous edge to both his roles and his life. Drawing on exclusive interviews with colleagues and friends, this biography from the author of Hellraisers paints an intimate picture of a complex, much-loved man. From the mystery of his place of birth through his formative years with the Royal Shakespeare Company, it charts his celebrated performances, his turbulent relationships and his drunken antics.
Actress Charlotte Rampling's early life included schooling and holidays in France and much time spent with her sister, Sarah, who committed suicide in 1967. The truth about the tragedy was initially kept from Charlotte and she then shared the secret with her father until her mother's death. This short memoir is written in elegiac, fragmentary and sometimes poetic style and includes photographs from the family archive.
Gerry Dukes
The distinguished Beckett scholar Gerry Dukes presents a photographic biography of one of the most interesting and challenging writers of the 20th century. Illustrated with family snapshots, formal portraits and many informal photographs taken during rehearsals and performances of his plays, the book traces Beckett's life from his birth in Dublin in 1919 to his death in Paris, his adopted home, in 1989.
The Adventures of the Crumpsall Kid
Mike Harding
The comedy for which Mike Harding became well known in the 1970s and 1980s grew out of increasingly lengthy stories told between songs during folk-club performances, and was inextricably linked to his Lancashire background. This memoir focuses on his early life in post-war Crumpsall, his Irish Catholic upbringing and schooling, memories of Manchester in the early 1960s and his formative musical experiences playing in beat groups while studying for his A levels.
Jérôme Larcher
Jérôme Larcher traces Charlie Chaplin's life and work from the London music hall to his tremendous success as the Little Tramp, and from the films he made in Hollywood after the advent of 'talkies', to his later work in Europe – minus the baggy trousers and bowler hat.
A Woman at War
Marlene Dietrich Remembered
J David Riva;Guy Stern
An icon of Hollywood's golden era, Marlene Dietrich first made her name in the Deutsches Theater in Berlin in the 1920s. The most famous German performer of the 1930s, Dietrich was a vocal critic of the Nazi regime, bravely denouncing it and later working to promote the American war effort. Recalling the great star during this turbulent period, this book is a collection of interviews with a range of people who knew her, from GIs to well-known fellow entertainers.
Tim Ewbank;Stafford Hildred
Now regarded as a national treasure, Joanna Lumley began her career as a model before becoming an actress and starring in well-known series such as Absolutely Fabulous and The Avengers. Her early life abroad, her complicated love life and her film and TV career are described in this lively biography, which brings the story up to date with her recent campaign for Gurkha rights.
Sheila Hancock
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My Autobiography
Ronnie Corbett
Ronnie Corbett (1930-2016) was one of Britain's best-loved entertainers. Here he discusses his life and work with characteristic self-deprecating wit, including his Edinburgh childhood before the war; early ventures on the stage and screen; encounters with stars such as John Cleese, Noel Coward, Tony Hancock and Spike Milligan; plus his solo sitcom Sorry! and - of course - his long-running partnership with Ronnie Barker.
The Cinematic Legacy of Frank Sinatra
David Wills
Already famous as a singer, Frank Sinatra (1915–1998) entered the film industry as a comedic song-and-dance man, but soon demonstrated his versatility in roles ranging from romantic leads to tough guys in films such as Ocean's 11 (1960) and The Manchurian Candidate (1962). This book celebrates his career as an actor, pairing more than 200 photographs and posters with reflections from co-stars including Grace Kelly and Sammy Davis Jr, and essays from his children Nancy, Tina and Frank Jr.
De Niro
The star of landmark movies including Mean Streets, Taxi Driver, The Deer Hunter and Sergio Leone's legendary Once Upon a Time in America, Robert De Niro is indisputably one of the greatest actors of his generation, famous for his total immersion in roles such as Jake LaMotta in Raging Bull. This biography from the author of Rat Pack Confidential follows the trajectory of De Niro's career as actor and director, but also examines the life of the man behind the many characters.
Absolute Pandemonium
There's no one quite like Brian Blessed: actor, storyteller, mountaineer and coffin-maker. In this frank, riotous memoir he recalls his childhood in a Yorkshire mining town, his breakthrough on Z Cars, falling for Katharine Hepburn, raising hell with Peter O'Toole, meeting the love of his life, the actress Hildegard Neil – and punching Harold Pinter down a flight of stairs. 'No long dramatic pauses this time, Harold; he got one right on the side of the jaw. Wham!'
Brando's Smile
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Susan L Mizruchi
Marlon Brando (1924–2004) is remembered for his charismatic screen presence, rugged good looks and rebellious stance. Drawing on unpublished documents, letters, the actor's own library and interviews with friends and colleagues, this major biography presents a very different portrait of the fascinating private man: a civil-rights activist and intellectual who collected 4,000 books, rewrote scripts to sharpen his dialogue, loved the poetry of Emily Dickinson, and embraced other cultures and let them shape both his politics and his art.
Alexander Thiltges;Yann-Brice Dherbier
Destined for the limelight from childhood, Elizabeth Taylor (1932–2011) was just twelve when National Velvet made her a star. And while later films such as Cat on a Hot Tin Roof (1958) and Who's Afraid of Virginia Woolf? (1966) established her depth and power as an actress, she was better known for her many marriages and passion for diamonds. Illustrated with photographs, this handsome book charts her life and career, her turbulent relationship with Richard Burton, and her charity work. Off-mint.
Candice Bal;Yann-Brice Dherbier
'Everything you see I owe to spaghetti.' Sophia Loren (b.1934) is one of the most magnetic actresses in the history of cinema, yet her off-screen life has been a quiet one, and she counts motherhood and her 40-year marriage to producer Carlo Ponti (1912–2007) as her greatest achievements. This lavish photographic biography covers her impoverished childhood, her early films and her subsequent international success, and explores the contradictions of her public and private personae.
In this touching memoir, the luminous Italian Oscar-winner reflects on her life, from her infancy in war-torn Naples to the dizzy heights of worldwide fame. Each chapter begins with an object such as a letter or a photograph that brings back memories: of her family; of her late husband, Carlo Ponti; of friends and co-stars such as Cary Grant, Frank Sinatra, Marlon Brando and Richard Burton; and of the joy and satisfaction of being a mother and a grandmother.
Jack Duckworth and Me
Bill Tarmey;Alan Hart
Bill Tarmey (1941–2012) played the lovable rogue Jack Duckworth in Coronation Street for 31 years until his character was killed off during the show's 50th anniversary in 2010. His story of growing up in post-war Manchester, singing in working men's clubs, and then finding his niche playing a rascal whose life uncannily mirrored his own will be cherished by all fans of Britain's longest-running soap.
Joanna Lumley is not only a star of stage and screen but a national treasure. Luckily her magpie instincts have preserved a hoard of memorabilia that make this illustrated memoir a visual feast, with photos from her Indian childhood to the present. There are souvenirs of her early modelling career, her celebrated roles in The New Avengers, The Pink Panther and Absolutely Fabulous and, of course, the causes about which she feels passionate. Felt tip mark on upper trimmed edge.