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Chartered Accountants play important role in nation-building: Ashok Gehlot
The Chief Minister of Rajasthan made the remarks in an online address to the inaugural session of the sub-regional conference of the Central India Regional Council of ICAI.
February 05, 2022 06:07 pm | Updated 06:10 pm IST - Jaipur:
Rajasthan Chief Minister Ashok Gehlot. File
Chartered accountants play an important role in nation-building and they owe it to the people to spread financial awareness among them and make them understand various aspects of the economy, Rajasthan Chief Minister Ashok Gehlot said on February 5.
"A CA audit is always considered reliable as it is done after a lot of scrutinies. In such a situation, it is their responsibility to maintain their credibility while playing their important role in nation-building," the Chief Minister said.
Mr. Gehlot made the remarks in an online address to the inaugural session of the sub-regional conference of the Central India Regional Council of ICAI.
He said in the pre-Budget meeting held recently, the representatives of the State Level Tax Advisory Committee gave many good suggestions.
"It will be our endeavour to include these suggestions in the Budget so that entrepreneurs can be benefitted from it," he promised.
Observing that the role of Chartered Accountants is important in strengthening the economy of the country, Mr. Gehlot said it is their responsibility to discharge their positive role honestly for the development of the country and the State.
"They should give the right opinion to the industrial and commercial institutions and the general public about the payment of tax," he added.
He said chartered accountants should encourage their clients to invest more as they act as a strong bridge between the government and business houses.
At the same time, they can provide proper information to the entrepreneurs regarding the schemes, policies and programmes of the government, Mr. Gehlot said, adding that Rajasthan has given many famous chartered accountants to the country.


By Dr. Aaron R. Stewart, Ph.D.
Brooke Henderson Swing Analysis - Amazing!
On this "Whatever Wednesday" episode, we discuss how Justin Thomas has been expressing his opinion and doing it in a way that demands attention. Even at only 25 Justin seems to understand his role and the ability he has to use his platform to encourage positive change to the game. We also discuss the true meaning of a Fred Shoemaker saying we shared early, namely: "Only when you have felt it, can you fix it." The definition of "feel" in this statement goes much deeper than what many assumed. Finally, we discuss how to use Tour Averages to keep our expectations for our golf game where they should be so that we can get maximum enjoyment out of the game. Let's tee it up! #golf #pgatour #golfers #lovegolf #golfday #whyilovethisgame #golflessons #golflife #anythinggolf #beautifulgolfcourses #lovegolf #betterdatabettergolf #dataaxisgolf #golfislife #golfball #golftournament #golfcourse #golfrange #golfnews #instagolf #golfswing #golfing #golfaddict #nowhitebelts #talkbirdietome Follow us on Instagram, Facebook and YouTube.
Wednesdays are now "Whatever Wednesdays." Giving us a chance to review all things golf for the week, the news, the feel good, and maybe feel bad stories, essentially... whatever. In today's show, we discuss how the schedule change has hurt the Honda Classic, how our perception of Rory McIlroy here in the US probably more positive, where Rory's decision to skip the Irish Open has raised some ire from his hometown paper. We discuss the difficult and near disaster at the Monday qualifier for the Honda Open, and even a little bit on the ridiculous outcry on backstopping. Give me a freaking break; let it die already. And finally, my favorite, the very first installment of "Fred Says," which will be a segment where I share a quote or teaching of Fred Shoemaker of Extraordinary Golf, and then discuss the how it can help us in golf and sometimes even in life. It is what a mentee should always do for a mentor, so here we go. Let's tee it up!
Wow, that was a weird one at the Genesis Open this year. Much to cheer about with the improvement to the tournament going forward joining with Tiger Wood's charities and becoming an Invitational, more money, more extended exemption. Very cool. JB Holmes and Justin Thomas have history, which we didn't learn about until after the tournament, but did that mentor/mentee relationship play a role in the outcome. We look at the number that matter in both $$, but also in performance up against the performance benchmarks we use to manage and monitor our games. Let's tee it up!!
On Golf.com there was an interesting article entitled "Meet the biomechanist who's changing golf - and can help you gain distance." The article is about Dr. Sasho MacKenzie, who is a researcher of Human Kinetics at St. Francis Xavier University in Nova Scotia. You may know him from the work he has done with the BodiTrak. In this article, it tells us of the easiest way to get more speed in our swing. Additionally, we look at some consistency numbers of top tour pros and see how their career average stacks up with their 2018 and 2019 numbers to see how they are trending. It's for fun. Let's tee it up!
Phil's wins for his 5th time on the hallowed grounds of Pebble Beach Golf Links. He started his round 3 strokes back and ended up winning by three after posting a seven-under 65 to lap the field. Phil also lets us in on why Pebble Beach is such a special place for him and his family. We take a look at Phil's stats and see where his performance was above his 2018 averages and carried him on to the win. We also compare Phil's statistics to our established benchmarks, to continue refining how we are going to track our games and make sure we get better this summer. Let's tee it up!
Another impressive win for Bryson DeChambeau, who continues to prove to the world that using training aides that provide instant and correct data can transform you game. Not only your swing, but also you mental toughness, as you can prove to yourself that you golf swing is solid. You can know you golf swing, it won't be mystery to you any longer. And with that, your performance will go up, just ask Bryson. We also get into the one-length iron discussion, with some insight I learned personally after being fitted and playing with one-length clubs for a few months. Let's tee it up!
An amazing display of golf this week from Justin Rose, using new equipment for only the 2nd time in competition. What can we learn from Justin Rose? Let's get into the data and see how Justin's performance holds up compared to his averages and our performance bench marks. Let's tee it up!
On today's show we play two soundbites from Lee Westwood and Bryson DeChambeau, as they play in the Dubai Desert Classic. Lee provides us with great pearls of wisdom into how we need to carry ourselves mentally on the course to achieve our best golf. Bryson provides some brilliant insight into how we can prepare ourselves to be prepared and consistent on the golf course. Both pieces of advice are wonderfully helpful in assisting us get better at this great game. Let's tee it up!
Equipment manufacturers are producing better putters, grasses on modern greens are quicker due to better agronomy and watering strategies. It all means that we have better surfaces, better technology, but we aren't making statistically more putts. So what it the problem? In a nutshell we can't read greens well enough to adjust to these conditions. What can we do about it? Let's tee it up!
This time of year, with the PGA Show going on, we will hear about all kinds of new technology and products that are supposed to help us play better golf. There is also many coaches getting together to share notes, which always brings up the question of do we learn by feel or by technology. The answer? Let's tee it up!
Rickie Fowler is not playing Titleist Pro Vs anymore? My world just came crashing in around me? What in the world is going on around here?!? Rickie claims he has found the Taylormade TP5x golf ball to be better in the wind and he has picked up some distance with his irons. So how to you choose a golf ball? Does it really matter that much to us amateurs? Let's tee it up!
It may appear Adam Long was an overnight success, but not so fast my friends!! Adam has been earning this win for a very long time. On this Data Monday, we will go over some cool stats of Adam's from his PGA career, and we will even look at some from Phil Mickelson for comparison. We will also take a quick look at how Adam performed up against our amateur game improvement benchmarks. Let's tee it up!
Phil tweeted out he was a "little rusty" before his start at the Desert Classic, then he went out and shot a 60. It was the 3rd 60 of his playing career, which no one else has done on the PGA Tour. But this 60 was his lowest score to par in his career. So what was rusty? Let's tee it up!
Winter is a perfect time to work on our putting strokes. In this podcast we will go over 3 drills that won't cost you anything, are easy to set up and do, and will transform your putting game into a strength. These drills focus on making a precise stroke, making sure the putter face is dead square at impact, and insuring you are not moving during the stroke. Use these three drills until Spring and get ready to take money from your buddies pockets. Let's tee it up!
Do You Expect To Get Better When You Play?
Do you expect to get better while playing golf? Why? What do you do to make sure you are working on the weaknesses of your game? Are there strategies that make getting better possible while playing? Or is there a time to perform and a time to practice? Should our mindset be different for each? Let's tee it up!
Kuch Again! What Can We Learn on This Data Monday?
Jordan Spieth - Push the Panic Button?
After his first round of the Sony Open many "experts" were discussing their worries for Jordan Spieth and his game. Robert Damron (who is one of the most entertaining guys on Golf Channel) claimed it was DEFCON 7 for Speith (whatever that means). But Jordan has a plan and he is going to be just fine. Let's tee it up!
What can we expect from Jordan Spieth this year? Are you optimistic he will play better than last year? Why or why not? Based on some of his comments this might be a very, very important year in his long-term success. Let's tee it up!
Maybe one of the most under discussed topics in golf. How should we choose targets to better improve our performance and clearly communicate our intentions? There are some common mistakes to avoid, but better target strategies can drastically improve your scoring, and in some cases, instantly. Let's tee it up!
How Are You Swinging It?
If someone asked you how do you swing the golf club, how would you answer that? Could you answer? Can you describe your golf swing? Do you know if well enough to classify it? Explain it? Critique it? And if you can, will it make you a better player? Let's tee it up!
The Flagstick... In Or Out?
Better Goals for 2019 - Putting & G.I.R.
How do you plan to improve your golf game in 2019? In the last show of our Data Driven series we will review some 2018 PGA Tour statistics to calculate some reasonable benchmarks to measure our own games, and use those to set proper expectations for maximum enjoyment and maximum game improvement in 2019. On today's show, we examine proper expectations for putting and Greens-in-Regulation statistics. Let's tee it up!
How do you plan to improve your golf game in 2019? In our year-end Data Driven series we will review some PGA Tour statistics to calculate some reasonable benchmarks to measure our game against, and to then help us set up proper expectations for maximum enjoyment and game improvement in 2019. On today's show, we examine proper expectations for scrambling and sand saves. Let's tee it up!
How do you plan to improve your golf game in 2019? In our year-end Data Driven series we will review some PGA Tour statistics to calculate some reasonable benchmarks to measure our game against, and to help us set up proper expectations for maximum enjoyment and game improvement in 2019. On today's show, we examine approach shots. Let's tee it up!
How do you plan to improve your golf game in 2019? In our year-end Data Driven series we will review some PGA Tour statistics to calculate some reasonable benchmarks to measure our game against, and to help us set up proper expectations for maximum enjoyment and game improvement in 2019. On today's show we examine driving accuracy. Let's tee it up!
Practice doesn't make perfect unless we practice the right way... And even then, it's golf, so perfect is a stretch. Practicing the wrong way can seriously hamper your chances or ever playing the right way. Let's tee it up!
Data Monday - Davis and Dru Lovely!
Davis and Dru Love do it again! Jack Nicklaus quips he hopes Dru gets his card and can't defend next year. :) And we get into some cool data on how much the top 20 players in the world make per tournament and per day on average. Let's tee it up!
Think of your best rounds. Do you remember who your playing partners were? Was it the way you played, your final score, or who you were with that made the round memorable? Let's tee it up!
Can you increase your swing speed by just trying to swing "faster?" Hank Haney seems to think so! Let's tee it up!
Many are shouting that we need to get fit, for our ball, for our shafts, for our clubs, but do we? Do fittings really benefit the high-handicapper? The low handicapper? Or is it a ploy to get us to spend more? Let's tee it up!
No one can explain what causes them, no one knows how to fix them, no one really wants to talk about them, so we are going to anyway. 😂 Let's tee it up!
Data Monday - Tricky Blick!
What would you do if your clubs were stolen the night before the biggest round of your life? How about shoot 63 with borrowed clubs?!? Let's tee it up!
Some folks are sadly asking the question "what's wrong with Tiger Woods?" It is a bad question, the answer is... Tiger Woods isn't the old Tiger Woods anymore, and that is a great thing. Let's tee it up!
From his knees, Tiger Woods took an abbreviated swing and knocked his ball out of a bush, back toward the fairway. Upon further review, using HD video, it could be clearly seen that he had carried the ball on the face of his club or essentially perform a double hit, which is against the rules of golf. After some discussion by the officials, Tiger did not receive a penalty stroke, even with video proof of the infraction. Did Tiger Woods cheat? Let's tee it up!
You know who you are, and you know what you have done, and we are tired of it. How can you easily identify a sandbagger? Let's tee it up!
Jon Rahm has his own way about him. A fellow Sun Devil and a unique approach to the game. Let's tee it up!
A Tim Herron Sighting: The Return of Lumpy!
He has to be one of the most beloved golfers of our generation. Tim "Lumpy" Herron, the Minnesotan, the comedian, the entrepreneur, the husband, the dad, the legend! Let's tee it up!
Patrick Reed - Setting Off Fires and Playing On Fire!
Love him or hate him Patrick Reed has the game and the mentality to be around a very long time. Let's tee it up!
Can you remember back to when you played a great round of golf? Do you remember what you were focused on? Were you "outside" yourself? Let's tee it up!
Technology in golf is here to stay, despite the lamenting of some. Let's tee it up!
Cuts Made Data, plus we chat about Hosung Choi's unique swing and win on the Asian Tour, and Monday would not be complete without a recap on "The Match" of Tiger and Phil. Let's tee it up!
We go against conventional wisdom here, but after looking at a few positions in your swing, you too can more easily find your best grip. Be aware, as we work together your swing plane will simplify and improve, as it does, you may need to adjust your grip to take advantage of your new simplified action. Let's tee it up!
Can being thankful on the golf course improve your play? Let's tee it up!
Does a pre-shot routine really help your golf game? The answer is... maybe. It only helps if you use it the right way if not, it could actually be hurting your game. Let's tee it up!
Data Monday: Howell Cool Was That?!?
A quick recap of the RSM, and some data on Charles Howell III. Whatever happened to "Chuckie 3 Sticks?" Let's tee it up!
Is competition good for our golf game? It is good for us?
Golf can be frustrating and with frustration can come anger. We typically don't play our best while angry, so what should we do about it?
Rules are to created to make golf "fair" for all of us, but sometimes the rules, as written, are just plain cruel.
Our spouses are a huge part of our lives, and thus our golf life. How we interact with them concerning golf is vitally important. Especially if you want to keep playing golf.
Should you take the plunge and be fit for custom clubs? The quick answer is... Maybe. Let's discuss!
Yes, I did almost die, and yes Bubba Watson did, in fact, save my life... But I have never met the man. Let's get to it.
Why do really well hit golf shots feel so good? What is behind that? Maybe, just maybe, it has something to do with this.
Do you need a golf coach? Do you want a golf coach? What should we look for in a golf coach? Let's get into it!
In Malcolm Gladwell's book "Outliers" he puts forth the concept that we can achieve mastery in something at around 10,000 hours. My opinion inside this episode.
They have been six years in the making, but the USGA has finally released new golf rules for the 2019 season. We review the top 10 rule changes that we will deal with the most. The game of golf just got more straightforward, and hopefully, the pace of play will pick up too!
Most people are shocked when they actually take time to analyze the performance data of PGA touring pros. The data should help us develop more reasonable performance expectations.
He is known as a mad scientist, which is great. Bryson uses data to rapidly improve his golf swing, we can too.
How choosing the "right" targets can improve your play.
We all love golf magazines, but are they good for your golf swing?
Some rely on feel. Tiger talks that the "feels" are coming back. What?!?
My first experience at an Extraordinary Golf School, and my rampant stupidity on full display!
Through a series of really unfortunate and fortunate events, we now know how to help you rapidly improve your golf swing. To get better at anything we need accurate, instant and usable feedback. The more accurate, the more instant and the more usable the better! Yep, that's us.


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5 Promising Companies to watch out for in the Batten Disease Therapeutic Market
01 Aug 5 Promising Companies to watch out for in the Batten Disease Therapeutic Market
Posted at 17:59h in Biotechnology	by	admin 0 Comments
Neuronal Ceroid Lipofuscinosis (NCL), or more commonly known as Batten disease, is a group of rare lysosomal storage disorders attributed to the dysfunction in the autosomal recessive gene, which causes mutations that hinder efficient cell functioning. They disrupt the cell's natural waste disposal mechanism leading to a build-up of proteins and lipid. According to the data made available by Batten Disease Research and Support Association, an estimated 2 to 4 births per 100,000 are afflicted with this disease.
The disease progressively affects the neurological functioning and includes symptoms such as seizures and visual impairment, behavioral changes, Ataxia, cognitive decline to name a few. There are over 14 known forms of Batten disease and the symptoms and progression vary from person to person, making diagnosis difficult.
Advancements in diagnostic tools and methodology have made diagnosis quicker and more efficient, with methods like DNA analysis/genetic testing, measurement of enzyme levels, electroencephalogram (EEG) skin or tissue sampling helping in faster and accurate diagnosis. However, no cure exists and treatment is limited to alleviating symptoms. Currently BioMarin's Brineura (cerliponase alfa) is the only enzyme replacement therapy available, which can slow down the progressive loss of motor ability in patients with batten disease.
A report by Zion Market Research, the Batten Disease treatment market which was worth nearly USD 35.09 million in 2017 will grow at a CAGR of 2.79% between 2018 and 2023 to reach USD 41.39 million. The growth can be attributed to increasing research and development efforts by companies to find the elusive cure for this debilitating disease.
We take a look at some of the companies which are at the forefront of innovation in this space.
Abeona Therapeutics (NASDAQ :ABEO)
Market Cap: $146.50M; Current Share Price: 2.98 USD
Data by YCharts
A clinical-stage biopharmaceutical company, Abeona Therapeutics is developing AAV-based gene therapies for Batten disease. ABO-202 and ABO-201 are two of its candidates meant for the treatment of CLN1 and CLN3 forms of Batten disease. The company is also working on creating therapeutics for Epidermolysis Bullosa (EB) and Sanfilippo syndrome.
ABO-002 is designed to use an AAV9 vector platform, to deliver a functional copy of the PPT1 gene, the defective CLN1 gene, using a combination of intravenous and intrathecal administrations. This can promote proper metabolism in lysosomes by activating the PPT1 enzyme.
The company is planning a phase I /2 trial, after the acceptance of an investigational new drug application by the FDA in May 2019. Results from preclinical trials have demonstrated the safety and tolerability of the drug, along with improvement in survival rates, motor function and cognitive abilities in mice. The drug has been awarded an Orphan Drug Designation and a rare pediatric disease designation in the U.S, in addition to an Orphan Drug Designation in the E.U.
Image Source: Company
The company has a state-of the-art cell and gene manufacturing and production facility to address its needs. Its pipeline also consists of candidates for the treatment of Cystic Fibrosis (ABO-401) and Retinal Diseases (ABO-50X). Furthermore it is working on an undisclosed target named the AIM Vectors, touted to be a next generation AAV product.
Polaryx Therapeutics (Private)
Polaryx is pioneering novel oral small molecule therapeutics to treat lysosomal storage disorders and neurodegenerative disorders such as Batten Disease, Alzheimer's and Parkinson's. Using its key mechanism of action based on transcription Factor EB (TFEB), the regulator of lysosome biogenesis, to upregulate cellular functioning to eliminate cellular waste, it is developing a solution for a range of disorders.
PLX-100, its lead product candidate for treatment of Batten disease, is a retinoid X receptor-α (RXRα), which binds to PPARα thereby up-regulating the expression of TPP1 mRNA in brain cells via the PPARα/RXRα heterodimer, in addition to activating PPARα that promotes the production of transcription factor EB (TFEB) in brain cells, which in turn results in lysosome biogenesis. It can also prevent apoptosis and reduce inflammation.
The company received an Orphan Drug Designation from the FDA for PLX-100 indicated for the treatment of Late Infantile Neuronal Ceroid Lipofuscinosis (LINCL) and other forms of NCL also known as Batten Disease. In addition, it has also received an ODD from the European Medicines Agency (EMA).
Its approach is based on the use of repurposed drugs thereby reducing the risk, time and costs involved in developing candidates from scratch. It has an ongoing research and development collaboration with the Rush University Medical Center. It is exploring the possibility of developing solutions for other indications such as Niemann-Pick type A and B disease (NPD), Krabbe disease and Sandhoff disease.
RegenxBio (NASDAQ: RGNX)
Market Cap: $1.68B; Current Share Price: 45.91 USD
The company is developing a one-time gene therapy RGX-181, which has been granted an orphan drug designation and a rare pediatric drug designation by the FDA, for the treatment of late-infantile neuronal ceroid lipofuscinosis type 2 (CLN2) disease, a common form of Batten Disease. RGX-181 uses the AAV9 vector to deliver the tripeptidyl peptidase 1 (TPP1) gene, whose deficiency is the primary cause of CLN2, directly to the central nervous system (CNS).RegenexBio is preparing to file an investigational new drug application (IND) for the same in 2019.
RegenexBio is developing a therapy that involves one-time administration of the TPP1 enzyme, which has the potential to arrest the neurological decline and progression of other symptoms. The company uses its proprietary NAV technology platform, to deliver specific genes for therapeutic usage using adeno-associated virus vectors. It has exclusive rights to AAV7, AAV8, AAV9, AAVrh10 and over 100 other novel AAV vectors (NAV Vectors), including over 100 patents covering composition of matter, methods for their manufacture and therapeutic uses.
In addition, its pipeline consists of therapeutic candidates for wet AMD, Diabetic retinopathy, Mucopolysaccharidosis Type II (MPS II) or Hunter syndrome and homozygous familial hypercholesterolemia (HoFH). It has partnership and development agreements with big pharma companies such as Novartis (NYSE: NVS), Sarepta (NASDAQ: SRPT), Abeona (NASDAQ: ABEO), Prevail (NASDAQ: PVRL) and Takeda (NYSE: TAK) to name a few.
Theranexus (EPA: ALTHX)
Market Cap: $15.94M; Current Share Price: 4.40 EUR
A biopharmaceutical company creating solutions for CNS related disorders, Theranexus' is using its proprietary technology to improve the efficacy of CNS drugs that already exist, thereby reducing developmental risks, time-to-market and market entry costs. The company's efforts are based on the work of founders Franck Mouthon and Mathieu Charvériat, who identified the importance of non-neuronal cells (or "glial cells") in neuron response to CNS drugs. They devised a technology that could not only improve the neuron response but also increase the efficacy of CNS drugs, by tweaking the structure of glial cell networks.
The company has signed an agreement in principle with the Beyond Beyond Batten Disease Foundation (BBDF) for the development and commercialization of BBDF 101, giving it a six-month exclusivity period to reach a final agreement. BBDF 101, is a proprietary combination of drugs that leverages the synergistic effect of two approved compounds. The candidate has shown promising results in preclinical research and will be presented for an Investigational new drug approval (IND) to the FDA.
In addition its pipeline consists of THN201, a combination of donepezil+ mefloquine, to treat neurocognitive disorders linked to Alzheimer's disease and THN101, a combination of amitriptyline + mefloquine for treatment of neuropathic pain and THN102, its first product, which is a combination of modafinil, and flecainide, intended to act on the glial cells. It is currently being evaluated in phase II clinical trials. The drug candidate enjoys patent protection until 2034.
It has a strong intellectual property rights portfolio covering combinations (compositions of matter) and their specific applications.
Recursion Pharmaceuticals (Private)
Recursion Pharmaceuticals uses a combination of artificial intelligence, automation and experimental biology to create life-altering medical innovations. The company's technology can build millions of cellular images which are then analyzed using AI-based software, to identify potential compounds, which can be developed to fight a variety of rare diseases.
The company has an extensive pipeline of clinical and discovery stage candidates, besides two candidates under phase I trials. It also has development and partnership agreements with big pharma companies in areas such as oncology, inflammation, immunotherapy and ageing. In January 2019, the company announced that its partnership with Takeda pharmaceuticals has resulted in the evaluation of Takeda's preclinical and clinical molecules in over 60 unique indications, with over half-a-dozen new therapeutic candidates being identified. Takeda exercised an option for two drug candidates from these studies, in two rare diseases.
Recursion has also entered into a research agreement with Sanofi Genzyme (NASDAQ: SNY) for using its proprietary drug repurposing platform to identify new uses for Sanofi's clinical stage molecules in a variety of genetic diseases.
Disclosure: I/we have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours.
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https://bdsra.org/what-is-batten-disease/
https://battendiseasenews.com/batten-disease-treatment/
https://www.newswire.com/news/polaryx-therapeutics-received-orphan-drug-designation-from-the-20349351
https://www.polaryx.com/index.html
https://www.recursionpharma.com/approach-2/
https://www.recursionpharma.com/press-article/recursion-announces-options-exercise-by-takeda-and-extension-of-ai-enabled-drug-discovery-collaboration/
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ABEO, Abeona, Abeona Therapeutics, ALTHX, Batten Disease, Behavioral Changes, Best Batten Disease Stock, Biopharmaceutical, Diabetic, DNA, Drugs, EPA, FDA, Genetic, Immunotherapy, Inflammation, NASDAQ, Neuronal Ceroid Lipofuscinosis, Novartis, NVS, NYSE, Polaryx Therapeutics, Prevail, PVRL, Recursion Pharmaceuticals, RegenxBio, RGNX, Sanofi, Sarepta, SNY, SRPT, TAK, Takeda, Technology, Theranexus
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redpajama_set_name: RedPajamaCommonCrawl


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Q: Is it safe to resize a partition while writing to it? I'm working on a script for automatically setting up Amazon Linux servers. I create them with 100gb virtual disks, but the main partition is always 8gb. No problem, I call sudo resize2fs /dev/sda1 at the start of the script to expand it to the full 100gb.
The process is fairly slow, though. Later on in my script I download various tools and components and set them up. I was wondering if it's safe to do that in parallel with the resize. Intuitively it seems like it would not be safe to write to a partition that's in the process of getting resized, but I thought I'd ask in case there's some clever magic Linux does that makes this ok.

A: Enlarging a mounted volume has been officially supported for ext3 and ext4 for some time now. I don't know of any strong assessment regarding a change in safety. Obviously both the resizing and the other activities take even longer when done on parallel.
But it seems strange to me that this takes so long. In my experience shrinking is slow but enlarging fast. Maybe you should open another question about resizing optimization. Maybe you can do something about the image in order to speed up this process.

redpajama_set_name: RedPajamaStackExchange


Home Miscellaneous NVIDIA GeForce Experience – Optimising Your PC the Easy Way.
NVIDIA GeForce Experience – Optimising Your PC the Easy Way.
Being the owner of a not so gaming optimised PC, I often look at PC games like Far Cry 3, and Black Ops 2 as if they're far, far in the distance knowing that my little old PC couldn't run them even with all of the settings on low. I'm often checking http://canirunit.com to see what games I can play before committing to, and handing over my card details to buy them but that might be all over thanks to the NVIDIA GeForce Experience.
The NVIDIA GeForce Experience is a handy program from NVIDIA that helps optimise video game settings for a variety of PC set ups. No matter what your system, it'll go through your list of games and tweak the graphics settings so you get a much smoother and better gaming experience. You don't have to have an NVIDIA GPU either so that's super handy!
First it checked my GPU driver version and updated accordingly. I had an update and all I had to click was two buttons and it began downloading and installing the driver. For those of you who don't check your GPU driver often, this is a handy piece of kit just for that. It took around 10 minutes to complete and my computer screen flickered on and off and stretched a little, but once it was complete everything went back to normal – this is to be expected.
Next I chose to scan my computer for a list of games and a nice bit of info popped up whilst doing so; "GeForce Experience optimises your games by downloading personalised graphics settings from the NVIDIA Cloud." – Fancy. This process took just as long as the update. Once completed it gave me a list of three games (out of the possible 10 I have installed) and out of those three only one had the ability to be optimised.
I chose to optimise the one game, even though it warned that my computer might not be able to run the game with the optimised settings.. a little strange considering the program is supposed to optimise the game to my computers specs..
Overall the NVIDIA GeForce Experience has every potential to be a great utility to optimise computers of all types. At the moment it's barely out of the closed beta that NVIDIA had going for about a month so the library of computer settings are pretty scarce, especially for lower end computers like mine with slightly older components, but I think if you had some of the currently supported games it'll work better for you. So far there's just under 50 supported games, but they are some of the latest titles like Far Cry 3, Borderlands 2, DmC: Devil may Cry, and Hitman Absolution.
Give it a try by downloading the beta here, and then let us know how you got on in the comments below.


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WP livestock report – August 2, 2018
Aug 2, 2018 Markets
Small producers can keep their turkeys
Looming yield reports key to mustard prospects
Jul 30, 2018 Markets
AGT announces intentions to privatize company
New ag school to focus on applied learning
The U.S. national live price average for barrows and gilts was US$49.43 per hundredweight July 27, down from $53.34 July 20.
U.S. hogs averaged $62.50 on a carcass basis July 27, down from $76.61 July 20.
The U.S. pork cutout was $76.97 per cwt. July 27, down from $85.52 July 20.
The estimated U.S. weekly slaughter to July 28 was 1.987 million, down from 2.382 million the previous week.
Slaughter was 2.234 million last year at the same time.
In Canada, the July 28 Signature Five price was C$167.94 per 100 kilograms, down from $179.95 the previous week. On a per hundredweight basis, the price was $76.18, down from $81.62.
The Canadian Bison Association said Grade A bulls in the desirable weight range sold at prices from C$5.90-$60 per pound hot hanging weight. U.S. buyers are offering US$4.60 or more with returns dependent on exchange rates, quality and export costs.
Grade A heifers sold up to C$5.80. U.S. buyers are offering US$4.40.
Animals outside the desirable buyer specifications may be discounted.
Ontario Stockyards Inc. reported that 956 sheep and lambs and 55 goats sold July 23. All lambs and good quality sheep traded at prices $7-$10 cwt higher. Goats sold steady.
Beaver Hill Auction in Tofield, Alta., reported that 1,159 sheep and 426 goats sold July 23.
Wool lambs lighter than 54 lb. were $205-$250 per cwt., 55-69 lb. were $220-$250, 70-85 lb. were $220-$249, 86-105 lb. were $220-$240 and 106 lb. and heavier were $215-$230.
Wool rams were $106-$125 per cwt. Cull ewes were $95-$151.
Hair lambs lighter than 54 lb. were $200-$230 per cwt., 55-69 lb. were $220-$250, 70-85 lb. were $220-$245, 86-105 lb. were $220-$235 and 106 lb. and heavier were $200-$218.
Hair rams were $117-$145 per cwt. Cull ewes were $90-$125.
Connections: keys to success
Producers urged to lock up their fertilizer supplies
Being prepared is key to successful risk management
China's corn needs likely to fall as ethanol plan slashed
Canfax report - Jan. 16 - 2020
WP livestock report - Jan. 16, 2020
more markets →
Don't bet the farm with your grain marketing strategy
Crush margins, currency, charts show support for canola futures
guide business
Introducing next steps into your farm operation


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Dirk on last road trip through B.C.
Ice overage defenceman will swing through the Okanagan where he grew up in five-game trip through B.C. Division.
Dec. 5, 2013 5:00 p.m.
For Jagger Dirk, there's no place like home.
He may not be heading through Penticton, but it will be close enough.
The Kootenay Ice are heading through the B.C. Division in a five-game road trip, and will swing through the Okanagan where the overage defenceman grew up.
Due to scheduling issues, the Ice and B.C. Division teams alternate travel, as Kootenay heads on the road once every two years, while the opposition comes up to Cranbrook on alternating seasons.
This will be his third and final trip of his WHL career going back through his stomping grounds.
"Being 20 and the last time I'm able to go through that B.C. road trip, it's going to mean a lot to me," said Dirk, following a 5-1 loss to the Oil Kings last Saturday night at Western Financial Place, "because I started my WHL career in Vancouver five years ago, so it's going to be bittersweet."
Entering his fifth season of his career, Dirk has developed to be a staple on the back end with an offensive touch, and, like his jersey number, is currently fifth in team scoring with three goals and 15 assists.
Dirk began his junior career in the BCHL, playing with the Salmon Arm Silverbacks, before being called up to the Ice full time, starting with his first career WHL game against the Giants on Dec. 2, 2009—a 6-2 win for Kootenay.
"16 [years old], came in and played Vancouver where my dad played his Canucks career, it's pretty special," continued Dirk. "Hopefully we end it the right way, with a sweep, that'd be nice. We're definitely capable of doing it if we play the right way."
So far, the road trip hasn't gone favourably for the Ice.
The team dropped a 3-0 decision to the Royals in Victoria, and despite putting in a better effort in Vancouver, the Giants stole a 3-2 victory on some solid goaltending.
The Ice will take on the Kamloops Blazers on Friday, which are dwelling in the basement of the Western Conference but that's no excuse to take them lightly.
It will be a reunion for the two teams that consummated a trade earlier in the season that sent former Ice players Collin Shirley, Matt Thomas and draft picks to Kamloops in exchange for Landon Cross and Tim Bozon.
Ice assistant coach Jay Henderson is under no illusions that they have their work cut out for themselves.
"It's going to be some tough games still coming up, and it'd be nice to come out ahead on this trip with three wins, three opportunities to play," he said, after Wednesday's loss in Vancouver. "But I thought tonight's performance was much better, it was just about capitalizing and we didn't do that, but the effort was there, for sure."
While Kamloops is struggling, Kelowna is on the opposite end of the spectrum, sitting in second place in the Western Conference and on top of the B.C. Division.
With Cranbrook-born head coach Ryan Huska leading from the bench, the Rockets have only one loss in 14 games. Four Rockets players are property of NHL teams that were picked up in the 2013 draft.
Both games should have some familiar faces in the stands cheering for Dirk.
"I know lots of friends and family are going to come to the Kamloops-Kelowna games, so I'm excited to see them," said Dirk. "I haven't seen them in a while, but I've obviously got to concentrate on the game when it's game time."
Giants edge Ice with 3-2 win
Nitros fizzle with two weekend losses


Site24x7's Root Cause Analysis (RCA) Report offers valuable insights on the various issues in your IT infrastructure. In this post, we will see how to interpret an RCA report and how to put RCA to optimal use in identifying and addressing performance and network issues.
Root Cause Analysis; what makes it different?
RCA is different from a conventional downtime alert. Conventional downtime alerts contain details like start time of the instance and Traceroute if available, which is sufficient for you to know what has happened. However, the critical question as to why it happened remains unanswered. You need to know what caused the issue to immediately get down to working on it.
Root Cause Analysis automatically generates a plethora of information to arrive at a definite conclusion as to what triggered a downtime. RCA intends to determine the root cause of specific downtime or performance issues. In short, RCA aims to answer questions like what went wrong, how it went wrong and why it went wrong.
Checks from Primary location and re-checks from the Secondary locations.
This section shows you the current status of your website when polled from the Primary and Secondary monitoring locations. This will have downtime details, duration, and location wise reason for the outage.
This screenshot is the exact error returned when the monitoring stations tried to connect to your website. This kind of screenshot acts as a proof or evidence of what exactly happened when the site was trying to reach the remote server. In our example, the site returned 'Connection Timed Out' error.
Ping Analysis can be used to gather valuable insights like the number of packets sent, packet loss and response time. Traceroute analysis lets you diagnose network issues and helps you identify any vulnerability in your network. Traceroute is a simple tool to show the actual pathway to a remote server. This can be anything from a website that you attempt to connect to a remote device on your intranet network. All traceroutes except for Ping monitor utilizes TCP protocol. Ping Monitor generates ICMP based traceroute.
This is a complete health check of your Name Servers and Email Servers. It retrieves records like SOA details and Name Server performance.
MTR, also known as My Traceroute combines the functionality of the Traceroute and Ping in a single interface. Combining these functionalities, MTR constantly polls your remote server and allows you to see how the latency and performance changes over time. Since the output is constantly updated in MTR, it allows you to collect actual performance trends and averages, and gives you a clear picture of the network performance over a varied time period.
The same set of tests will be conducted from all your configured secondary locations as well. This is to confirm the actual downtime.
This is where the RCA report tells you the probable reason for the outage instance based on the above results. The conclusion reached in this case is "Connection to the server got dropped in the Hop 16". This is obviously something to do with the network. Armed with this conclusion, you can immediately get down fixing the issue.
For Website, REST API, and REST API Transaction Monitor type, Site24x7 generates a trouble or Down RCA report. On the contrary, RCA reports are not available for SSL, Website Defacement, and Domain Expiry Monitor. We would love to hear from you on how the RCA has been helpful in identifying and troubleshooting issues. Share your valuable feedback in the comments.
It sounds great, but how can I get it to run automatically when my website goes down?
This should automatically be ran when your site goes down.


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FOUNDATION_EXPORT double Pods_test_TestsVersionNumber;
FOUNDATION_EXPORT const unsigned char Pods_test_TestsVersionString[];

redpajama_set_name: RedPajamaGithub


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New law to reduce distracted driving signed by governor
TACOMA – A bipartisan effort by state lawmakers to target distracted driving received the governor's endorsement today. The Driving Under the Influence of Electronics Act updates the 2010 state law regarding the use of personal electronic devices by people when they are behind the wheel.
Sen. Ann Rivers, R-La Center, and Rep. Jessyn Farrell, D-Seattle, worked together throughout this year's legislative session to build support for the measure in the Senate and House of Representatives. It received strong bipartisan votes shortly before lawmakers concluded their regular legislative session April 23.
"I wish we didn't need a stronger law, but it's clear that people need a new reason to concentrate on the road ahead instead of something else in the car," said Rivers. "I'll bet most people who drive our highways have witnessed the kind of risky behavior this bill is meant to discourage."
"Because of this bill, our law-enforcement officers will be able to do an even better job of keeping our roads safe," Farrell said. "They see drivers holding phones and other devices all the time, but the wording of our law has made it extremely difficult for them to actually do anything about it. That will now change, and it will help save lives."
Holding a cell phone to one's ear or texting while driving is already prohibited under state law. But other uses of electronic devices – such as sending messages or posting photos through apps like Facebook, Instagram, or SnapChat – were not specifically prohibited because those technologies were not as prevalent in 2010.
Rivers and Farrell had proposed distracted-driving legislation in 2015 and 2016, respectively. After joining forces, they chose against proposing a measure that could quickly become outdated due to ever-changing technology, in favor of a straightforward approach. The Driving Under the Influence of Electronics Act prohibits any holding of a personal electronic device, watching video on such a device, or using a hand or finger to use the device's features – other than to activate or deactivate a function.
Pushing a button with one finger to initiate hands-free calling is permitted, as is the use of citizens' band or ham radios in vehicles.
Legislators voted to have the updates take effect in 2019. However, Gov. Jay Inslee chose to veto that part of the bill today. Now the new law will instead take effect July 23, as will most other laws created during the legislative session that ended April 23.
"We wanted to give both drivers and law enforcement ample time to prepare for these stronger restrictions. Now that the governor has dramatically shortened the timeline, people need to be ready much sooner," Rivers said.
The House passed Farrell's version of the bill (House Bill 1371) in early March, just after the Senate adopted Rivers' version (Senate Bill 5289). It was Rivers' bill that reached Gov. Jay Inslee's desk after changes proposed by Farrell were approved by both chambers.
The bill was signed along with two other impaired-driving measures, HB 1614, and SB 5037. All three measures support the state's continued Target Zero efforts, which aim to reduce traffic fatalities and serious injuries on Washington's roadways to zero by 2030.
Washington State House Democrats > Blog > New law to reduce distracted driving signed by governor


Gold is the most valuable resource in the wartune adventure game and as you progress through the world of wartune and increase in level, the need of that gold will increase by 10 fold. Gold is produced by your city depending upon what level your town hall has reached. There are many other ways to obtain gold though and it is very important for your success that you take advantage of every way you can produce gold. Note that some wartune gold production abilities in wartune will not be available until you reach a certain level (Gold Refinery is not unlocked until you reach level 24).
Gold can be produced by levy from your town hall, doing bounty quest, daily quest, campaigns, increasing the gold skill in your guild, increasing the technology in your academy, reaching new levels, farming, gold mines in the wilds, and other various ways through-out wartune. Your cities base production of gold will increase as you increase in level and you upgrade your town hall. Upgrading your town hall will also increase the levy you can obtain every day.
You can do a maximum of 20 bounty quest per day, doing these quest will give you exp and gold. These bounty quest are randomly generated from the Bounty Hall in your city every 30 minutes. To obtain the most amount of gold and experience you will want to focus on the bounty quest that pay the highest bonuses. Daily quest are quest that are set by wartune and do change from time to time. You can locate the daily quest from your quest menu by clicking on the scroll at the bottom right side of your screen. The amount of gold varies on the daily quest so be sure to check them every day.
You can obtain gold by doing wartune game campaigns though the campaign button or from the hall of heroes. Obtaining this gold is random and may not be available on every campaign that you do. You can obtain this gold from chest or from coin purses laying on the ground.
You can increase your cities gold production by leveling up the gold boost skill in your guilds tower. The level that you can purchase (purchase with guild contributions) depends upon the level of the skill tower in your guild. The gold power boost skill will increase your gold production by a certain percentage.
As you increase in level you will be granted a certain amount of experience and gold in the form of main quest. The amount of gold you receive is based upon the level you are reaching.
It is my opinion that farming is the best way to produce gold in wartune. You have the ability to plant gold (and other resources) once every few hours. The amount of time it takes for your crops to mature depend upon the level of your land and the seed that you are planting. Because you can plant a new crop 5, 6, or even 7 times a day, you have the ability to produce a vast amount of gold. There are different level of seeds so the amount you crop will depend upon not only the level of your farm land but also the level of the seed planted. You also have the ability to help "harvest" (or steal) gold from your friends farm.
3 times a day there is a wartune world boss fight that allows you to get gold and daru. The amount of gold that you can receive from the boss fights are based upon the amount of damage you do to the boss. The more damage you do the gold you will receive. If you reach 1% of damage to the boss you will also get an additional bonus of 50k in gold. The final hit to the world boss will reward you with 1 million+ in gold (at the time of writing this the final boss blow gave a reward of 1.2 million in gold).
Based on the ranking of your Arena status, you can claim a certain amount of Gold and Daru every 3 days. The higher level Wartune arena ranking that you have, the more gold and daru that you can obtain. Currently you are allowed to do 20 arena duels every day.
There are other methods in wartune to claim gold. You have the ability to gain gold from Altar spins in your guild, these are known as guild blessings. You can claim gold from the VIP Wheel with VIP Tokens - To see a detailed secret wartune game hint of how to claim 580k in gold from the VIP Wheel, visit TheLeague's private forum. You can also receive gold from the daily login bonus and from clearing campaign maps.
For those that dont mind putting money into the wartune game, you can also receive gold as a bonus when you purchase Balens. There are several levels you can purchase which will determine the amount of gold you get as a bonus. From time to time wartune will run specials that will give you more gold as a bonus. You can also perform alchemy which exchanges Balens for gold, careful though because this could get expensive real fast.
Wartune gold mines are an excellent way to keep gold production going on a constant basis for your city. Gold mines will spawn in the wilds 2 times a day. The level of these gold mines will depend upon what location you have your castle on the world map (Autaric Plains, Murken Forest, Fetid Swamp, Deathly Sands, Erandel).
Claiming a gold mine is easy, you enter the wilds and locate a gold mine that you would like to take over. Locating gold mines at a higher level would obviously give you more gold production per hour. Click on which gold mine you would like to attack and your character will walk to that gold mine and begin an attack.
You can take over other players gold mines also but be aware when attacking these gold mines you will face that player in a battle for the gold mine. It will not cost you anything for losing but it really is just as easy to go find another gold mine. A vast amount of gold mines are spawned which gives you plenty to choose from without the need to attack another players gold mine.
You are allowed a maximum of 2 gold mines and they do have an active time on them. The timer on the gold mines are between 8 and 11 hours. Usually new gold mines spawn around 0:00 am PDT time (the sever time). You want to make sure you login often to check your gold mines so you constantly keep gold production going for your city.
Academy Gold Research - In your academy you have a gold technology skill that will increase your cities gold production per hour. This skill can be increased equal to what your game characters level is at. To produce the most amount of gold for your city you should always keep this skill maxed-out and equal to your characters level. The higher the level this skill is the higher your cities gold production per hour will be.


Search the Community: Showing results for tags 'combat'.
Self-explanatory. If you are hit with a sharp object, you will "bleed". There will be a trail of "blood-stain" decoration blocks behind you and coming from you, and new particles will drip from the screen looking like red water droplets. You will lose 5 health points every 3 seconds until you put a new item of a bandage on you (right clicking, should be crafted by 2 string or 2 wool, depends) then you will stop bleeding, or you will stop bleeding naturally (2 minutes after last sharp object hit). Bleeding is also caused by arrows. This will only happen with a "Sharp" object, which brings me to another good point. Maces and hammers should have a gray tag under them that says "Blunt" and they don't make an enemy bleed, but do more damage combat wise. Knives and javelins will have a white tag under them called "Sharp". They do a lot of damage combat wise and induce "bleeding" to the mob (Unless it is a skeleton, for obvious reasons). This can also happen to you, if a javelin throwing skeleton or a friend hits you with a sharp object. Anything I missed or you want to add, feel free to say so!
This is a Repost from the Combat Revamp thread. As I understand it, I hear many players are more interested in PvE. However, I wanted to get a poll of the People interested in this. Like Bioxx, I believe that we cannot treat this like real life. With the features so far, we are able to address many of the challenges we encounter in PvE and PvP. However, while we are not lacking much in principle, there are things that should exist that would make combat more immersive. To list a few: shields, armor weight, More projectiles weapons, Chain mail armor, War animals, Mob Upgrades. Some of which have been said in the Suggestion page. But here is how I see it: [*]Shields: From personal experience with using the Asgard Shields mod I've found that its use against projectiles were well founded, but its use in close courters combat is situational. For example: [*]If Cornered- It could be used to push back your opponent, like a shield bash. [*]If Jumped- it will allow you to stand your ground without breaking the flow of combat. [*]Armor Weight: If used in combination with shields, it could fixe many gaps in the flow of combat. From what I've seen of this mod which is similar to TFC (But more combat oriented), Mine Fantasy it creates a system of armor weight that may be appropriate for us. This would allow for more variety to a players choice of arsenal, may it be the light armor with ranged weapons choice, or heavy armor with melee weapons choice. However, like it was said by p122 in this Thread: This Issue can be resolve through choices by Player A: [*]If shields exist, he can use it to reduce the oncoming damage of his opponent as he advances and/or hope Player B advances into his range or Stops his barrage. [*]if War animals exist, He could use it to attack player B or expose him and/or If it is a Horse (An Armored Horse would be Ideal), use it to outrun his opponent. [*]He himself could attempt to shot his opponent dead while letting his armor take the damage. fast shooting, Preloaded weapons like a Crossbow would suit this need well. [*]More Projectile Weapons: Even though the current features of Ranged attack are sufficient to deal moderate damage, There is lack of GOOD disposable ranged firepower in TFC. The regular bow, although its arrows are disposable, lacks power and the Javelins, although powerful, lack disposability. I imagine this is intentional, yet this also hinders advanced combat and makes ranged weapons only second rate and used for inflicting slight damage and not to kill. This sort of feature was done well by our own home-grown mods ExtraFirma and the now abandoned Terra Bow Mod (Now Renewed). These sort of feature would grant players an edge in combat even if they lack strong armor, In addition, If added with my past mentioned features, It would link well together and make combat a little more strategized. [*]Chainmail Armor: This is more or less a feature that would suit well with Armor Weights, it would create and intermediate class of warrior that could afford to do both melee and ranged attack. The armor would vary against piercing and be better suited to deflect slashing than Crushing blows yet I believe it would receive a warm welcome from the TFC audience. [*]War Animals: This, for the most part, focuses on Horse. I have shared this opinion already in the Suggestion page and Dunkleosteus Stated: So I understand the circumstances of this feature a little better than the others. Yet I will state again, here, that I believe Horses clade in armor would enhance the combat structure of TFC with or without the addition of Armor Weights. It would grant greater mobility to player. In addition, like it was simply put in the Thread, I believe a Critical hit should be granted to horse bound players. On the other-hand, we currently possess Wolves, which if modified correctly, could become a better companion when attacking players. However, because of current changes they can no longer breed. This is sad and I fear that this may kill part of this idea, but I will let the admins correct me. [*]Mob Scaling: This is more of a PvE feature than PvP, but Mob Scaling would be create a vastly improved challenge to night combat. In principal, mobs would start with little armor or weapons and work up to stronger armors as the player or group average EXP exceeds the qualifier for better armed mobs. This would increase the challenge for mob battles. As to features like Skills and Magic, I believe we have to approach it cautiously. Too much focus on skills and the mod becomes like that MMORPG server pluggin. Too much focus on Magic and this mod becomes like Ars Magica or Thaumcraft (Not to say that there is anything wrong with the mods, Its just not my cup of tea). This doesn't mean that skills don't have a place, hell the EXP to Health system is a great feature, but is it necessary to have many more modifiers. As to magic, I do not know were to go with it, I just hope if it ever exists, it is purely additive. To me, this seems more of a Compilation than original idea, but then again, that is what this Thread needs. A little organization. Proposed Ideas: Inventory Limits: By Sting_AuerI think a system like this would work if we had set weights to all items (and weight cap for players). Also, make items have a certain size on the inventory grid. I.E. Equip Time: By RavenleftThis is well said in the Quote, a GUI that if interrupted, forces the player to stop equipping.
Just a simple question: for those of you who know of the game Chivalry, what would you think of having a similar combat system in TFC?


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FLIPOVER FRIDAY: NEW ARRIVALS AT iTUNES AND APPLE MUSIC
PlayboiCarti's surprise release is already screaming its way up Apple Music's chart and, despite no pre-sales, it's Top 10 at iTunes where Charlie Puth is the pace setter this flipover Friday.
Puth's second album, Voicenotes (Artist Partner), sits at #1, followed by Arctic Monkeys' Tranquility Base Hotel & Casino (Domino) at #2. The Monkeys are opening pop-up shops today in six cities—New York, Sheffield, England, and Berlin among them—to offer physical copies of their music and merch.
Bad Wolves, the Eleven Seven rock act that hit with their recent cover of The Cranberries' "Zombie," are at #3 with Disobey. The 12th studio album from alt-metal act Sevendust, All I See is War (Rise), is #4.
After announcing the release of a new album seven hours before it hit the Internet, Playboi Carti's Die Lit (AWGE/Interscope) drummed up enough business to get it to #7 at iTunes and #3 on Apple Music where it is this week's top rookie.
Beach House's aptly titled 7 (Sub Pop)—yes, it's their seventh album—is #8. Frozen: The Broadway Musical (Walt Disney) lets it go at #9.
Self Promotion, a four-song EP from Wale released Tuesday, is #12 at Apple Music and Ski Mask the Slump God's Beware the Book of Eli (Republic) is #14.
On the singles side at iTunes, Selena Gomez's track from Interscope's 13 Reasons Why: Season 2 soundtrack, "Back to You," sits at #2 followed by John Mayer's surprise drop, "New Light" on his Snack Money label, at #3.


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Strengthening the Palestinian Economy to Keep a Two-State Solution Viable
By Hardin Lang and Rudy deLeon Posted on April 13, 2016, 12:00 pm
It has been more than two decades since the signing of the first Oslo Accord, which set into motion a process that was designed to achieve a lasting peace based on a two-state solution. Subsequent rounds of diplomacy have failed to realize that vision. Growing numbers of Israelis and Palestinians have begun to question the "land for peace" bargain. Yet the strategic logic of a two-state solution, with an independent state of Palestine alongside the state of Israel, remains strong. Without two states—both viable, thriving, secure, and free—Israel faces a difficult dilemma in reconciling its identity as a Jewish state with its tradition of democracy.
The stalled peace negotiations have left Palestinians looking for other options to achieve greater control over their own affairs. Former Palestinian Authority Prime Minister Salam Fayyad has called for a long-term nation-building project independent of negotiations with Israel to set the foundations for an eventual Palestinian state. But various crises continue to chip away at the legitimacy of the Palestinian Authority, or PA. Plans for a Palestinian political transition also remain opaque. As one observer in the West Bank town of Ramallah put it, "There is no longer a story that Palestinians can tell themselves about how our lives get better."
In recent years, some Palestinians have shifted their rhetoric toward the pursuit of full economic and political rights as part of a so-called one-state solution. For his part, Palestinian President Mahmoud Abbas has sought to increase international pressure on Israel to force recognition of Palestinian statehood. This strategy hinges on a campaign to leverage international boycotts, divestment, and sanctions—or BDS—against Israel. But some BDS leaders have conflated opposition to Israeli policy in the West Bank with a challenge to the "legitimacy of the concept of Israel as a democratic and Jewish State"—a stance at direct odds with the objective of a two-state solution.
The next U.S. president will enter office facing an unresolved Israeli-Palestinian conflict. The new administration will need to take steps to sustain a two-state solution until a resumption of talks becomes politically feasible. As the Center for American Progress has previously argued, the window on a two-state solution is rapidly closing. Key security, institutional, and economic challenges must be addressed to keep that window open. This report looks at the set of economic challenges that must be tackled in order to maintain a viable Palestinian polity capable of anchoring a future Palestinian state.
Specifically, this report will identify practical measures to improve the lives of ordinary Palestinians and to create an increasingly self-reliant Palestinian partner—both essential ingredients of a two-state solution. That Palestinian partner's economy will need to create jobs and offer some measure of relief and growth to its people in order to keep a two-state solution from slipping out of reach. An agenda to strengthen the Palestinian economy, however, is not a substitute for political progress. The goal must be to give Palestinians the tangible opportunity to take charge of their own livelihoods and thereby sustain their aspirations to statehood.
Few elements of this agenda for growth are new. Since Oslo, there have been repeated and serious attempts by multiple U.S. administrations, European donors, and multilateral bodies to strengthen the Palestinian economy. Some plans have been implemented. Others have been stymied for extended periods. The Office of the Quartet—a body supported by the United States, the European Union, Russia, and the United Nations—is currently engaged in its own efforts to bolster the Palestinian economy. Going forward, any renewed American attempt to engage on a focused set of economic priorities should take into account the lessons learned over the course of past and present efforts.
To better understand the challenges facing the Palestinian economy, a team from CAP recently traveled to the Middle East and interviewed dozens of Palestinian entrepreneurs, bankers, and investors in the West Bank and the wider region. The field research made clear that any plan to economically empower Palestinians will require progress on two fronts. First, the United States will need to reengage diplomatically with Israel and the Palestinian Authority and push for the removal of specific barriers to Palestinian economic growth. Second, the United States and other donors will need to take practical steps directly with the Palestinians to foster that growth. Specifically, the United States should pursue an agenda designed to achieve the following:
Priorities for U.S.-Israel-Palestinian Authority diplomacy that include:
Insulating the payment of clearance revenues from the politics of Palestinian-Israeli relations
Easing restrictions on Palestinian employment in Israel, as recommended by Israeli security institutions
Improving the Allenby Bridge border crossing—a key trade and transportation route
Rationalizing the system for processing dual-use goods
Reducing movement restrictions inside the West Bank
Improving access to land in all areas of the West Bank
Priorities for direct bilateral and multilateral Palestinian economic engagement that include:
Improving domestic access to finance for Palestinians
Promoting sectors that show promise under current conditions
Improving transparency and reducing corruption inside the Palestinian Authority
Supporting a Palestinian Authority local public works program
It should be noted at the outset that this report will concentrate on the West Bank. The CAP team did not travel to Gaza. A comprehensive examination of Gaza's economy is beyond the scope of this research. But the pressing humanitarian and reconstruction needs of Gaza's population would appear to take priority over efforts to facilitate private sector growth. Any plan for Gaza must also take account of the political challenges and security threats posed by the continued misrule of Hamas.
Progress on any agenda for growth will likely be incremental and will require patience and determination. In the absence of a final status agreement, the next administration will need to steer a pragmatic course with a greater focus on what is achievable economically. Relations between the parties do not lend themselves to quick successes or major breakthroughs. But an agenda of smaller, concrete steps could achieve meaningful improvements in conditions for Palestinians and sustain hope for a two-state solution—as well as peace, security, and prosperity for Israelis and Palestinians alike.
Hardin Lang is a Senior Fellow at the Center for American Progress. Rudy deLeon is a Senior Fellow with the National Security and International Policy team at the Center.


You don't have to pay for new devices to get an upgrade – we can refurbish your old phones, Blackberrys and smartphones so they're as good as new. And it's not just cost-effective – it's good for the environment too.
We also work with operators and retailers who have end of line stock, surplus or customer returns of mobile phones and related products. We provide a take back facility and exit for all volumes. No matter how many units we have you can free up their value via the TSR buy back scheme.
Refurbished phones are often sent to emerging markets around the world, where there are no fixed line telephone networks and communities rely on mobile phones.
If you're looking to purchase refurbished phones then we can offer excellent deals on all mobile phones and accessories. To find out more please get in touch at info@tsrlimited.co.uk.


This three strand necklace is made of a mix of grey beads and tubes, peacock colored freshwater pearls, citrine tinted quartz and 6 mm round cantaloupe swarovzki crystals. What I find interesting is that the cantaloupe crystals only look green at night under artificial light.
This three strand necklace is more stunning than the picture portrays!
The findings of these ear-rings are made of copper and are hand-made. The crystal rondelles are peridot.
Twisted copper links and swarovski crystals make up this dangle ear-rings.


Celano is an upgraded apartment community in the prime location of South Downtown Orlando, FL (SODO). The urban charm of these modern one-bedroom apartments include stainless steel appliances, laminate wood flooring, large walk in closet's and in home washers & dryers.
Our pet friendly community features a salt water pool, fitness center, outdoor grill and recreation area, dog park and recycle center. Located in the new "HourGlass District" you can take part in the City Beautiful's latest and most unique neighborhood, featuring local favorites like Foxtail Coffee, HourGlass Social House, Pizza Bruno and more!
It is also just a short drive to Lake Eola Park where you can visit the Downtown Orlando Farmers Market, catch a show at the Walt Disney Ampitheatre and see the iconic Linton E. Allen Memorial Fountain light up at night with the city!


Volatility made a (timid) comeback in April and bond yields continued to surprise on the low side. Nevertheless, it was another solid month for international equity markets as the technology-heavy Nasdaq index crossed the 6,000 mark for the first time ever. Meanwhile, global investors' focus is progressively shifting towards non-US international markets as Europe and selected Emerging Markets have been collecting impressive amounts of foreign flows recently. In the Middle East, markets have been range-bound but the major news was definitely the decree by King Salman of Saudi Arabia to rescind salary cuts and reinstate bonus payments to thousands of civil servants.
While it could beg the question of how committed the Kingdom is in terms of reforms, this news is likely to boost con¬sumer sentiment and is supportive for growth.
Coming back to international markets, investors are now facing the usual question: "Should we sell in May and go away?" This is precisely the focus of our monthly investment strategy ("Seasonality and other stock markets cycle").
In the "Macro round-up", we take another look at Global inflation trends and conclude that upside risks are mounting, especially in the U.S. The "Hot topic" of the month is about the French Presidential election, which creates both risks and opportunities for fund managers. We then make the case for Active management, arguing that asset allocators should balance their exposure between passive and active instruments in a smart way.
In the second part of this monthly publication, we share our long-term optimism on Middle East equities.
We hope you will enjoy this Fourth issue.
Please do not hesitate to contact us if you want to discuss further any of these ideas.


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Edge Realty Recipe: Campari Cake
I personally love a spritz made with Campari vs the milder version, made with its slightly less bitter cousin, Aperol. The apéritif, though originating from Italy and extremely popular…
Written by Ryan & Juliana Wilson
Local Rhode Island Artist: Eric Lutes
"Best known as the actor who played Del on NBC's long-running hit comedy "Caroline in the City" among many other roles, Eric's first passion is fine art and painting. Eric…
What Impact Might COVID-19 Have on Home Values?
What Impact Might COVID-19 Have on Home Values? A big challenge facing the housing industry is determining what impact the current pandemic may have on home values. Some buyers are…
How Technology is Helping Buyers Navigate the Home Search Process
How Technology is Helping Buyers Navigate the Home Search Process [INFOGRAPHIC] Some Highlights: A recent realtor.com survey revealed that buyers are still considering moving forward with the homebuying process, even if they…
Coronavirus Stimulus Package
The unprecedented $2 trillion coronavirus relief package Congress signed by President Trump on Friday, March 27, has a lot to unpack in it. In fact, Congress is still hammering out…
Netflix and Chill: The Top 100 Movies of 2019
If you're like most of us, you probably haven't had much free time to catch up on the latest and greatest flicks on the big screen… That is, until now.…
Quarantine Baking: The Best Chocolate Chip Cookies of All Time
I love to cook, bake, and most of all- eat. Having this extra time at home allows us the opportunity to do more of all of the above and the other day,…
2021 Housing Forecast!
HGTV's Rhode Island DREAM HOME
The Holidays Aren't Stopping Homebuyers This Year
Your House May Be High on the Buyer Wish List This Holiday Season
Why Working from Home May Spark Your Next Move


text:
JUST IN: Top Biden Nuclear Waste Official Charged With Felony After Stealing Woman's Luggage
Biden official Sam Brinton was caught stealing Vera Bradley luggage at the Minneapolis airport and has been charged with a felony. Brinton works as the deputy assistant secretary of the Office of Spent Fuel and Waste Disposition at the U.S. Department of Energy.
On September 16, Minneapolis-St. Paul International Airport law enforcement were notified of a missing suitcase in baggage claim. The female victim said she went to retrieve her checked bag at a carousel and found it missing.
Records confirmed her navy blue Vera Bradley roller bag had arrived at 4:40 p.m. before going missing. According to a criminal complaint, when law enforcement reviewed surveillance footage they saw Brinton taking the missing bag from the carousel. Brinton went on to detach the women's luggage claim tag from the bag, deposited it into his handbag and "then left the area at a quick pace."
Sam Brinton, the "gender fluid" Deputy Assistant Secretary for Spent Nuclear Fuel and Waste Disposition in the Department of Energy, was charged with felony theft last month after stealing ~$2,500 worth of women's luggage at an airport. pic.twitter.com/y7ZUrBoylS
— BowTiedRanger (@BowTiedRanger) November 28, 2022
According to the complaint, Brinton did not check a bag on his flight to Minneapolis/St Paul Airport and had no explainable reason for going to baggage claim. Yet video survelliance shows that Brinton continued to use the stolen bag. On Oct 9 Brinton returned from Europe and was seen carrying the bag in Dulles International Airport footage. The victim positively identified her stolen bag and said the value of the bag and its contents exceeded $2300.00.
Twitter users used the opportunity to roast Brinton, with one user commenting on the Biden official's style saying "it makes way more sense when you realize he's just wearing whatever he finds in other people's luggage."
Sam Brinton's style makes way more sense when you realize he's just wearing whatever he finds in other people's luggage. pic.twitter.com/FVqNRsVKv7
— Kate Hyde (@KateHydeNY) November 29, 2022
Police interviewed Brinton on October 9 asking if he had taken anything that did not belong to him. But according to AlphaNews, he initially pretended his bag had gotten mixed up with another passenger, saying,
"If I had taken the wrong bag, I am happy to return it, but I don't have any clothes for another individual. That was my clothes when I opened the bag."
However Brinton apparently called the investigating officer back two hours later, to apologize for not being "completely honest." This time Brinton blamed fatigue saying he thought the bag was his. In his second story he said he was worried people would think he stole the bag, and "got nervous" and did not "know what to do" telling the police he left the victim's clothes in in the hotel room. Police did not find clothing left in the room and explained how the bag should be returned to Delta. The Department of Energy declined to comment and Brinton's hearing is currently scheduled for Dec 19.
Sen. Ted Cruz Calls On DOJ to Investigate Truckloads of Documents Biden Gave to Univ. of Delaware... Where Did Funding for Document Archival Come From? [VIDEO]


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Q: how can I upgrade chocolatey? Basically I am facing problem with after install node … now I am try to upgrade chocolatey..
after run this command choco upgrade chocolatey below message I found.. Windows 10

Chocolatey v0.10.15
Upgrading the following packages:
chocolatey
By upgrading you accept licenses for the packages.
Error retrieving packages from source 'https://chocolatey.org/api/v2/':
The operation has timed out

chocolatey was not found with the source(s) listed.
If you specified a particular version and are receiving this message,

it is possible that the package name exists but the version does not.
Version: ""; Source(s): "https://chocolatey.org/api/v2/"

Chocolatey upgraded 0/1 packages.
See the log for details (C:\ProgramData\chocolatey\logs\chocolatey.log).

Warnings:
chocolatey - chocolatey was not found with the source(s) listed.

Does anyone have any idea about this ?

A: Have you tried running the install command, this should just replace and update chocolatey:
Set-ExecutionPolicy Bypass -Scope Process -Force; [System.Net.ServicePointManager]::SecurityProtocol = [System.Net.ServicePointManager]::SecurityProtocol -bor 3072; iex ((New-Object System.Net.WebClient).DownloadString('https://community.chocolatey.org/install.ps1'))

Also please make sure you have set PowerShell to accept the security protocol to: $AllProtocols = [System.Net.SecurityProtocolType]'Ssl3,Tls,Tls11,Tls12' [System.Net.ServicePointManager]::SecurityProtocol = $AllProtocols [System.Net.ServicePointManager]::CertificatePolicy = New-Object TrustAllCertsPolicy
This has to be done before the choco install command.
Also, another way just to update node without updating Chocolatey is to just run the following command: choco install nodejs-lts --version=14.17.3 --confirm --timeout 216000;


text:
Location: Kennesaw, GA (USA)
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Within the political turmoil and high-profile demonstrations of the last week, supporters of President Donald Trump see a shining example of a rare commodity — a politician who has kept his word.
"He's fulfilling all of his campaign promises his first two weeks in office," said Anthony D'Amelio, a Republican business owner and state representative from Waterbury. "I can't believe the energy level of this man."
D'Amelio was the first state legislator to publicly endorse Trump, partly because he believed the brash New Yorker's outsider cred would shake up the system. "He's taking on some real controversial issues," D'Amelio said. "I knew he could pull it off ... It's a different day already in America and the guy's only been in office since Jan. 20."
Trump's first 11 days in office have been marked by massive protests around the nation. His defenders assert that the broad swath of the American public supports him. A Quinnipiac University poll conducted in early January, before Trump was sworn in, found narrow support for new limits on immigration.
Forty-eight percent of those surveyed backed "suspending immigration from terror prone regions, even if it means turning away refugees," the poll found. By a broader margin, 53 to 41 percent, voters supported requiring immigrants from predominantly Muslim nations to register with the federal government.
Trump's immigration policy is motivated by a strong desire to keep Americans safe, said Jeff Murray, a supporter from Andover. "We need to secure our borders," he said. "What if another Sept. 11 happens?"
Murray says he has heard a lot of heated rhetoric from Trump critics over the past few days. He recalled his own feelings of disappointment following Barack Obama's election.
"There's no need to take it to the streets," said Murray, who works at Pratt & Whitney and leads the Andover Republican Town Committee. "Give the man a chance."
"President Trump ... we saw what he ran on, we saw how he responded to illegal immigration," said Mary Ann Turner, chairwoman of the Enfield Republican Town Committee. "He talked about the fact that we need to protect the United States of America first. The reaction is really overblown in my opinion."
Throughout his campaign Trump pledged to "Make America Safe Again" and in December 2015 he called for a "total and complete shutdown of Muslims entering the United States until our country's representatives can figure out what is going on."
Trump's executive order last week suspended travel to the United States from seven majority-Muslim countries for 90 days, suspended the federal refugee program for 120 days and indefinitely blocked Syrian refugees. But Trump and his supporters cautioned against calling it a "Muslim ban" or a "travel ban," noting its temporary nature.
On the morning of Trump's inauguration Roy Perkins of East Haddam said he would be "the greatest president since Lincoln and Washington." On Tuesday Perkins wasn't let down.
"I think [Trump] hit the ground running," he said. "He's following up on what he said and I agree. I would have been disappointed if he didn't come out of the gate and work on this."
Sam Pollastro, the Republican chairman in Derby, said the weekend protests in places like California, New York and Connecticut don't represent the sentiment in the rest of the country, like the Rust Belt states of Pennsylvania, Ohio and Michigan that helped propel Trump to victory. In Pollastro's city, Trump beat Clinton by 6 points.
"Nobody should be surprised, he campaigned on it," Pollastro said. "There's no reason to think he wouldn't follow through with it."
His fellow Derby Republican, Tony Staffieri, the former mayor of the state's smallest city, said Trump supporters would have pushed back if the president hadn't acted quickly on his campaign pledges.
"I voted for Trump, but let me tell you, if he doesn't do what he said he's going to do I'll be the first one to talk bad about him and say 'Throw the bum out,'" said Staffieri, an Italian immigrant who voted for Trump primarily because of his economic promises.
Protests over the immigration executive order have gone too far, Staffieri said, and critics are "100 percent undermining him," he said.
"I think he's not being given ... the opportunity to be able to implement and be successful with the things he wants to do and the reasons why he was elected," Staffieri said.
Nationally, some high-profile Republicans have come out against Trump's executive order, like Sens. John McCain of Arizona and Lindsey Graham of South Carolina. Turner, the Enfield Republican chairwoman, dismissed their criticism.
"He spoke bluntly, and now all of the sudden these guys are shocked by it?" she said. "He put his whole plan out on parade for two years. ... He's being clear and articulate on the fact that he wants our country to be protected."
Jim Campbell, a Westport resident and the former chairman of the Greenwich Republican Town Committee was an early Trump supporter in a town that flipped from Mitt Romney in 2012 to Hillary Clinton in 2016.
"The Trump administration is executing on what Donald Trump campaigned on," Campbell said. "He said we should stop and do a rethink on security procedures from everybody coming to the country from high-terrorist activity countries. And that's what he's doing."
Campbell said the execution of the order could have been cleaner, but noted that Trump was working without a full cabinet because the Senate has held up some of his nominees. He said Sally Yates, the acting attorney general who was dismissed after she refused to devote Justice Department resources to defending the order, should have resigned "rather than engage in this public spectacle."
Do millionaires really leave the state when taxes get higher?


text:
AP® French Language & Culture
All-Gender Course; Prerequisite - Successful completion of at least three years of high school French required, suggested four years of high school French or three years with an immersion experience; Full-year course
AP® French Language and Culture is designed to provide deeper understanding and broader application into French language. By the end of this course, students will be able to interpret and discuss historical and cultural topics, as well as current events pertaining to the various communities that exist in the Francophone world. Students explore six themes throughout the course: Personal and Public Identities, Families and Communities, Global Challenges, Science and Technology, Contemporary Life and Beauty and Aesthetics. Students use information from a wide range of sources to engage in learning, discussion, and analysis activities as they deepen their understanding and confidence in the grammatical structures of the language. Throughout the year, students engage in reading, writing, speaking and listening activities and assessments. Students are expected to delve deeply into the topics, take AP®-style assessments and prepare for the AP® exam.
"I enjoyed the opportunity to apply something I value, a feminist representation, to a French topic, the French film Van Gogh, and I felt our work was thorough and interesting."
"I feel like I've definitely begun to understand French language and culture more in-depth. Notably, learning about social issues such as immigration and racism has helped me draw parallels between French culture and American culture as well as understand French society."
"I think I've improved my listening to French and writing long paragraphs in French, which I'd never done too much of before this class. Listening especially used to really overwhelm me, but I don't even think twice about it anymore."
Examples of signature activities and projects for this course are:
French Film Study: During the first semester, students will have the opportunity to watch a French-language feature-length film and complete a creative project to share their understanding and review of the film.
Invention Project: During the second semester, students will have the opportunity to learn about recent finalists in a French invention competition and then they will get to create their own invention that addresses a problem or need they have identified in a Francophone region of the world though their coursework earlier in the year.
Small Group Conversation: Throughout the year, students will have regular opportunities to meet in small groups via Google Hangouts for French conversation and to build connections within the class.
OUR RESEARCH-BASED APPROACH TO TEACHING LANGUAGES ONLINE
One Schoolhouse designs competency-based courses with the student-teacher relationship as the cornerstone of our personalized pedagogy. While students excel in our language AP courses, for many years we did not offer full sequence language courses because there was little research to support the efficacy of online language learning at the early levels. The research shows that fewer than 1% of Americans are proficient in the language they studied in traditional classrooms. Not wanting this outcome for One Schoolhouse students, our goal is to inspire deep learning so we strive to ensure that the online learning experience increases the effectiveness of second language acquisition. In recent years, we have honed our approaches to delivering the four language competencies – reading, writing, listening, and speaking – in the online space, and have therefore endeavored to build out our Chinese, French, and Latin sequences. The limitations of other online language programs are mitigated by the centrality of the student-teacher relationship, including interactive sessions where students speak, listen, and translate with their peers and teacher, at One Schoolhouse. J.C. Narcy-Combes's research on second language learning online shows that, "meaningful interaction will trigger learning processes," which we know to be true anecdotally, and that, with intentional design, students can be taught to learn language effectively online. Carrier et. al. have more recently shown that educational technologies and online learning are rapidly transforming second language acquisition, and that intentional practice can create a highly effective digital experience. Because One Schoolhouse students have pathway options where they can practice in the target language at their own pace, get feedback from their teacher, interact with peers from around the country, and demonstrate their mastery through both traditional assessments and creative projects, students have the full complement of research-based learning activities in their online courses that you would expect to find in any independent school language program. Additionally, our language teachers have advanced degrees from American universities, are trained in both their language and the best pedagogical practices for delivering language online, teach in independent schools around the US, and are AP readers.
This course is approved by: the College Board, NCAA and the University of California.
Elizabeth Caldwell
Foreign Languages Teacher
BA Lafayette College
MSEd University of Pennsylvania