3′-deoxy-3′-[18F]fluorothymidine (18F-FLT) has been used to evaluate tumor malignancy and cell proliferation in human brain gliomas. However, 18F-FLT has several limitations in clinical use. Recently, 11C-labeled thymidine analogue, 4′-[methyl-11C]thiothymidine (11C-4DST), became available as an in vivo cell proliferation positron emission tomography (PET) tracer. The present study was conducted to evaluate the usefulness of 11C-4DST PET in the diagnosis of human brain gliomas by comparing with the images of 18F-FLT PET.
Twenty patients with primary and recurrent brain gliomas underwent 18F-FLT and 11C-4DST PET scans. The uptake values in the tumors were evaluated using the maximum standardized uptake value (SUVmax), the tumor-to-normal tissue uptake (T/N) ratio, and the tumor-to-blood uptake (T/B) ratio. These values were compared among different glioma grades. Correlation between the Ki-67 labeling index and the uptake values of 11C-4DST and 18F-FLT in the tumor was evaluated using linear regression analysis. The relationship between the individual 18F-FLT and 11C-4DST uptake values in the tumors was also examined.
11C-4DST uptake was significantly higher than that of 18F-FLT in the normal brain. The uptake values of 11C-4DST in the tumor were similar to those of 18F-FLT resulting in better visualization with 18F-FLT. No significant differences in the uptake values of 18F-FLT and 11C-4DST were noted among different glioma grades. Linear regression analysis showed a significant correlation between the Ki-67 labeling index and the T/N ratio of 11C-4DST (r = 0.50, P < 0.05) and 18F-FLT (r = 0.50, P < 0.05). Significant correlations were also found between the Ki-67 labeling index and the T/B ratio of 11C-4DST (r = 0.52, P < 0.05) and 18F-FLT (r = 0.55, P < 0.05). A highly significant correlation was observed between the individual T/N ratio of 11C-4DST and 18F-FLT in the tumor (r = 0.79, P = 0.0001).
The present study demonstrates that 11C-4DST is useful for the imaging of human brain gliomas with PET. A relatively higher background uptake of 11C-4DST in the normal brain compared to 18F-FLT limits the detection of low-tracer-uptake tumors. Moreover, no superiority was found in 11C-4DST over 18F-FLT in the evaluation of cell proliferation.
Imaging of cell proliferation and DNA synthesis is an attractive target for diagnosing and treating tumors. A fluorinated thymidine analogue, 3′-deoxy-3′-[18F]fluorothymidine (18F-FLT) (Figure 1A), has emerged as a promising positron emission tomography (PET) tracer for evaluating cell proliferation in various malignant brain tumors [1-4]. Fluorothymidine (FLT) is phosphorylated by thymidine kinase-1 (TK1) and trapped inside the cells. The application of 18F-FLT as a marker of cell proliferation is based on the assumption that cellular 18F-FLT trapping is a representation of thymidine incorporation into DNA [5,6]. However, previous studies including our recent report have shown that the major portion of 18F-FLT uptake is due to increased transport and influx through the disrupted blood-brain barrier (BBB) but not increased phosphorylation process by TK1 [7,8]. Non-enhancing tumors with an intact BBB have limited transport for the tracer, and their cell proliferation cannot be adequately assessed by 18F-FLT [4,9]. Moreover, little 18F-FLT is actually incorporated into DNA synthesis; rather, it is retained intracellularly after mono-phosphorylation by TK1 . Therefore, 18F-FLT uptake in the tumor does not reflect the whole DNA synthesis.
Radiopharmaceutical structures of 18 F-FLT (A) and 11 C-4DST (B). 18F-FLT, 3′-deoxy-3′-[18F]fluorothymidine; 11C-4DST, 4′-[methyl-11C]thiothymidine.
Recently, Toyohara et al. developed a new thymidine analogue, 4′-[methyl-11C]thiothymidine (11C-4DST) (Figure 1B), for cell proliferation PET-imaging tracer [11,12]. 11C-4DST is resistant to degradation by thymidine phosphorylase and incorporated into DNA synthesis . 11C-4DST showed high-tumor uptake (sensitivity) and high-tumor selectivity in a rodent tumor model . In a pilot study in human brain tumors, 11C-4DST showed little uptake in normal brain tissue, resulting in low-background activity for imaging brain tumors . 11C-4DST PET demonstrated rapid uptake in aggressive tumor masses, whereas no uptake of 11C-4DST was seen in clinically stable disease . 11C-4DST might be superior to 18F-FLT in evaluating cell proliferation and treatment response and predicting prognosis as 11C-4DST uptake represents the whole DNA synthesis process. The difference of radiopharmaceutical structure between 11C-4DST and 18F-FLT (Figure 1A,B) is small; however, it has been recognized that small molecular changes of the chemical structure sometimes make greater difference in the pharmacokinetics of PET tracers. The differences of thymidine kinase selectivity, nucleoside transporter subtype, and rate-limiting step enzyme between 11C-4DST and 18F-FLT may change the characterization of PET findings . No comparison has been reported between 11C-4DST and 18F-FLT for in vivo imaging tool of tumors. In the present study, we demonstrate our initial experience of 11C-4DST PET imaging and compare the images of 11C-4DST and 18F-FLT to evaluate usefulness in the diagnosis of human brain gliomas.
Twenty primary (n = 9) and recurrent (n = 11) human brain gliomas (9 men and 11 women; mean age, 52.9 ± 18.6 years; range, 22 to 79 years; median, 47 years) were included in this study (Table 1). Histopathology was examined on tissue specimens obtained by biopsy (n = 3) or resection (n = 17). Twelve patients had grade IV glioma (10 glioblastoma, 2 glioblastoma with oligodendroglioma component), 6 had grade III glioma (4 anaplastic astrocytoma, 2 anaplastic oligoastrocytoma), and 2 had grade II diffuse astrocytoma. The cellular proliferation activity of the tumor was determined by measuring the Ki-67 labeling index obtained by immunohistochemical staining with anti-Ki-67 antibody (1:50, Dako, Glostrup, Denmark). The percentage of tumor cells that stained positively for Ki-67 antigen was measured in the area containing the largest number of positive cells and was regarded as representative of the tumor proliferative activity. PET studies with 11C-4DST and 18F-FLT were performed within 1 week before the surgery. The two PET studies could be performed on the same day; however, we performed the examinations on two different days to decrease a physical burden on the patients because some of the patients were ill and the mean interval between the two examinations was 2.9 ± 1.7 days (median, 2 days). All patients underwent routine magnetic resonance imaging (MRI) examination including contrast-enhanced T1-weighted MRI. The use of 11C-4DST and 18F-FLT as a PET tracer was approved by Kagawa University, Faculty of Medicine Human Subjects Ethical Committees and informed consent was obtained from all patients before PET examination.
aDA: diffuse astrocytoma, AA: anaplastic astrocytoma, AOA: anaplastic oligoastrocytoma, GBM: glioblastoma, GBM-O: glioblastoma with oligodendroglioma component. 4DST: 4′-thiothymidine, FLT: fluorothymidine, SUVmax: maximum standardized uptake value, T/N ratio: tumor-to-normal tissue uptake ratio.
11C-4DST was synthesized according to the method described by Toyohara et al. , and the radiochemical purity of 11C-4DST was >95%. 18F-FLT was synthesized according to the method described by Martin et al. , and the radiochemical purity of 18F-FLT was >95%. All chemical reagents for tracer synthesis were purchased from commercial sources. PET examination was performed using a Biograph mCT64 PET/CT scanner (Siemens/CTI, Knoxville, TN, USA). The image systems enabled simultaneous acquisition of 74 transverses per field of view (FOV), with an intersection spacing of 3 mm, for a total axial FOV of 21.6 cm. The in-plane transverse-reconstructed resolution was 4.3 mm full width at half maximum (FWHM) in the brain FOV. No special dietary instructions were given to the patients before PET examination. Images were acquired with patients in the supine position, resting, with their eyes closed. CT data were acquired first (tube rotation time 0.6 s per revolution, 120 kV, 192 mAs, reconstructed slice thickness of 3 mm) and used for attenuation correction and anatomical localization of the tumors. For the 11C-4DST study, a dose of 229 to 587 MBq (mean, 391 ± 108 MBq) of 11C-4DST was injected intravenously, and regional emission images were obtained for 15 min, beginning 15 min after the 11C-4DST administration. For the 18F-FLT study, a dose of 237 to 342 MBq (mean, 309 ± 24 MBq) of 18F-FLT was injected intravenously, and regional emission images were obtained for 15 min, beginning 60 min after the 18F-FLT administration. Image reconstruction was performed using ordered subset expectation maximization (OSEM) with time of flight (TOF) and point spread function (PSF). The reconstruction parameters were 2 iterations and 21 subsets. The FWHM of the Gaussian filter was 3 mm.
11C-4DST and 18F-FLT uptakes were semiquantitatively assessed by evaluating the standardized uptake value (SUV). A region of interest (ROI) was set manually by an observer (N.K.) around the hottest area of each lesion or the area of tumor biopsy. The maximum value of SUV (SUVmax) of the ROI was regarded as the representative value of each tumor. To calculate the tumor-to-normal tissue uptake (T/N) ratio and the tumor-to-blood uptake (T/B) ratio, ROIs were set on the normal brain parenchyma (usually contralateral normal cerebral tissue excluding ventricles) and the vertical portion of the superior sagittal sinus with the aid of PET/CT fusion images. The mean values of SUV (SUVmean) of the ROIs were calculated. The T/N and T/B ratios were determined by dividing the SUVmax of the tumor with the SUVmean of the normal brain and the superior sagittal sinus.
All parametric data were expressed as mean ± SD. Paired Student t-test was used to compare the individual uptake values of 11C-4DST and 18F-FLT in the normal brain and tumor. Differences in the uptake values of 11C-4DST and 18F-FLT among different glioma grades were compared using analysis of variance. Linear regression analysis was used to evaluate the relationship between the uptake values of 11C-4DST and 18F-FLT and the Ki-67 labeling index of the tumor. The relationship between the individual 11C-4DST and 18F-FLT uptake in the tumor was also examined by linear regression analysis. Differences were considered statistically significant at a P value of less than 0.05.
Both 11C-4DST and 18F-FLT showed little uptake in the normal brain, and 11C-4DST uptake was visually higher than 18F-FLT in almost all cases. 11C-4DST showed a high uptake in the choroid plexus, whereas 18F-FLT showed a faint uptake. 11C-4DST and 18F-FLT provided identical PET images of the tumor in many cases (Figure 2A). Two primary diffuse astrocytomas that had no contrast enhancement in the tumor could not be visualized with 11C-4DST. One of the two diffuse astrocytomas could be visualized with 18F-FLT but the other could not. One recurrent glioblastoma with oligodendroglioma component that had multiple spotty enhancements in contrast-enhanced MRI was faintly visualized with 11C-4DST but well visualized with 18F-FLT (Figure 2B). In total, 2 of 20 tumors were well visualized only in 18F-FLT PET.
Gd-enhanced T1-weighted MRI, 11 C-4DST PET, and 18 F-FLT PET of two patients. (A) A 76-year-old woman with newly diagnosed glioblastoma (Case 8). Gd-enhanced T1-weighted MR image demonstrates a round lesion with irregular ring enhancement in the right frontal lobe. PET studies with 11C-4DST and 18F-FLT PET show almost identical tracer uptake in the tumor. Background uptake of 11C-4DST is higher than 18F-FLT PET. (B) A 29-year-old woman with recurrent glioblastoma with oligodendroglioma component (Case 20). Gd-enhanced T1-weighted MR image demonstrates multiple spotty enhancements in the right temporo-occipital lobes extending to the basal ganglia. The tumor is faintly visualized with 11C-4DST but well visualized with 18F-FLT. 18F-FLT, 3′-deoxy-3′-[18F]fluorothymidine; 11C-4DST, 4′-[methyl-11C]thiothymidine.
In the normal brain, 11C-4DST uptake was significantly higher than 18F-FLT (SUVmean; 0.34 ± 0.06 vs. 0.19 ± 0.04, P < 0.001 by paired t-test). Individual 11C-4DST SUVmax in the tumor was almost comparable to 18F-FLT except a few cases. Therefore, the average T/N ratio of 18F-FLT in the tumor was significantly higher than that of 11C-4DST (10.55 ± 5.45 vs. 5.96 ± 3.86, P < 0.001 by paired t-test) resulting in better tumor visualization with 18F-FLT. The average 11C-4DST T/N ratio in WHO grade II (n = 2), III (n = 6), and IV (n = 12) gliomas was 1.16 ± 0.14, 5.82 ± 2.8, and 6.75 ± 4.25, respectively. No significant differences of 11C-4DST T/N ratio were observed among different glioma grades. The average 18F-FLT T/N ratio in WHO grade II, III, and IV gliomas was 2.23 ± 0.68, 11.65 ± 5.63, and 11.39 ± 4.78, respectively. Again, no significant differences of 18F-FLT T/N ratio were observed among different glioma grades.
Linear regression analysis showed a significant correlation between the Ki-67 labeling index in the tumor and the SUVmax of 11C-4DST (r = 0.46, P < 0.05) and 18F-FLT (r = 0.49, P < 0.05) (Figure 3A). Moreover, a significant correlation was observed between the Ki-67 labeling index in the tumor and the T/N ratio of 11C-4DST (r = 0.50, P < 0.05) and 18F-FLT (r = 0.50, P < 0.05) (Figure 3B). A significant correlation was also observed between the Ki-67 labeling index and the T/B ratio of 11C-4DST (r = 0.52, P < 0.05) and 18F-FLT (r = 0.55, P < 0.05) (Figure 3C).
Linear regression analysis between the Ki-67 labeling index and the uptake values of 11 C-4DST and 18 F-FLT. (A) A significant correlation is observed between the Ki-67 labeling index in the tumor and the SUVmax of 11C-4DST (r = 0.46, P < 0.05) and 18F-FLT (r = 0.49, P < 0.05). (B) A significant correlation is also observed between the Ki-67 labeling index in the tumor and the T/N ratio of 11C-4DST (r = 0.50, P < 0.05) and 18F-FLT (r = 0.50, P < 0.05). (C) A significant correlation is also observed between the Ki-67 labeling index in the tumor and the T/B ratio of 11C-4DST (r = 0.52, P < 0.05) and 18F-FLT (r = 0.55, P < 0.05). 18F-FLT, 3′-deoxy-3′-[18F]fluorothymidine; 11C-4DST, 4′-[methyl-11C]thiothymidine; SUVmax, maximum standardized uptake value; T/N ratio, tumor-to-normal tissue uptake ratio; T/B ratio, tumor-to-blood uptake ratio.
A highly significant correlation was observed between the individual SUVmax of 11C-4DST and 18F-FLT in the tumor (r = 0.71, P < 0.001) (Figure 4A). A highly significant correlation was also observed between the individual T/N ratio of 11C-4DST and 18F-FLT in the tumor (r = 0.79, P = 0.0001) (Figure 4B).
Linear regression analysis of the individual SUVmax (A) and T/N ratio (B) of the tumor between 11 C-4DST and 18 F-FLT. A highly significant correlation is observed between the individual SUV max of 11C-4DST and 18F-FLT (r = 0.71, P < 0.001) and T/N ratio of 11C-4DST and 18F-FLT (r = 0.79, P < 0.0001). 18F-FLT, 3′-deoxy-3′-[18F]fluorothymidine; 11C-4DST, 4′-[methyl-11C]thiothymidine; SUVmax, maximum standardized uptake value; T/N ratio, tumor-to-normal tissue uptake ratio.
In the present study, we demonstrate three important findings in the comparison of imaging between 11C-4DST and 18F-FLT for clinical application. Firstly, both tracers had low-background activity in the normal brain and were able to visualize the tumor well except one non-enhancing primary diffuse astrocytoma in which both tracers failed to visualize the tumor. Both tracers had similar uptake values in the tumor, but the 18F-FLT uptake in the normal brain was relatively lower than that of 11C-4DST, resulting in better tumor visualization with 18F-FLT. Secondly, a significant correlation was observed between the Ki-67 labeling index and the uptake values of 11C-4DST and 18F-FLT in the tumor. We hypothesized that 11C-4DST is superior to 18F-FLT in evaluating cell proliferation as 11C-4DST uptake represents the whole DNA synthesis process. However, the correlation coefficients of 11C-4DST uptake values to the Ki-67 labeling index were slightly lower than those of 18F-FLT. Finally, a strong correlation was observed between the individual 11C-4DST and 18 F-FLT uptake values in the tumor.
For oncological use, measurement of the cell proliferation and DNA synthesis is an attractive target for imaging. A fluorinated thymidine analogue, 18F-FLT, has emerged as a PET tracer for evaluating tumor-proliferating activity in various brain tumors [1-4]. However, 18F-FLT has several limitations in clinical use that have been reported in previous studies [4,7-9]. Most critically, little 18F-FLT is actually incorporated into DNA synthesis, and 18F-FLT uptake in the tumor does not reflect the whole of DNA synthesis [7,8,10]. With the drawbacks of 18F-FLT, efforts were made to produce a more attractive PET tracer that can be used to evaluate tumor malignancy and cell proliferation accurately. Toyohara et al. focused on the 4′-thiothymidine (4DST) because of its metabolic stability and close similar structure to native thymidine . They synthesized 14C-labeled 4DST (14C-4DST) as a model compound of 11C-labeled alternative and demonstrated the evidence that 11C-4DST matches the concept of the ideal DNA-synthesis-imaging agent . Feasibility studies of 11C-4DST in rodent tumor models showed higher uptake than that of 18F-FLT and reflect the DNA synthesis rate [12,13]. Usefulness of 11C-4DST for the imaging of human brain tumors with PET was investigated in a recent pilot study by comparing the images of 11C-4DST and [11C]methionine (11C-MET) in six patients with various brain tumors . There was little uptake of 11C-4DST in the normal brain and rapidly growing brain tumors that were well visualized in contrast-enhanced MRI and 11C-MET PET were clearly seen in 11C-4DST PET. Although 11C-MET detected all the enhanced lesions in MRI, clinically stable (non-aggressive) tumors with enhancement were not detected with 11C-4DST. In addition, the distribution pattern of 11C-4DST in the tumor was not always identical to that of 11C-MET. Here, we report the first clinical study of comparing two nucleoside PET tracers for DNA synthesis, 11C-4DST and 18F-FLT, for in vivo imaging of human brain gliomas. 11C-4DST PET images were acquired for 15 min, beginning 15 min after the administration. The start time for imaging 11C-4DST was earlier than that for 18F-FLT PET imaging (60 min). We confirmed that 11C-4DST uptake and distribution in the tumor was almost fixed 15 min after 11C-4DST administration in a preliminary dynamic acquisition study. Two non-enhanced diffuse astrocytomas could not be visualized with 11C-4DST suggesting that 11C-4DST does not readily cross the intact BBB, and 11C-4DST uptake in the tumor rather depends on the influx through the disrupted BBB similar to 18F-FLT. The distribution pattern and uptake value of 11C-4DST in the tumor are almost identical to those of 18F-FLT except one non-enhanced primary diffuse astrocytoma and one recurrent glioblastoma with oligodendroglioma component in which only 18F-FLT could detect the tumor well, whereas 11C-4DST showed no and a faint uptake in the tumors, respectively. 11C-4DST uptake in the normal brain was visually and semiquantitatively higher than 18F-FLT. A previous clinical study reported that 11C-4DST is mainly metabolized by glucuronidation in the human body and largely accumulated in the liver . Other metabolites could be nonspecifically accumulated in the normal brain. Furthermore, a recent study has demonstrated that 4DST but not FLT can be transported via the nucleoside transporters . The active transport may cause higher uptake of 11C-4DST than 18F-FLT through the intact BBB in the normal brain though the amount of 11C-4DST transport is small.
In the present study, we examined 20 patients with various grades of gliomas and a mixture of primary and recurrent cases. There are critical limitations in the present study. Firstly, the total number of gliomas enrolled in this study was small for evaluating the usefulness of this new tracer, especially low-grade glioma. Secondary, primary, and recurrent cases should be separated when evaluating the usefulness of a BBB-dependent PET tracer, such as 11C-4DST and 18F-FLT. Recently, our research group has demonstrated that 18F-FLT PET is less useful for evaluating tumor malignancy and cell proliferation in recurrent gliomas compared with newly diagnosed gliomas . In the present study, no significant differences in the T/N ratio of 18F-FLT were noted among different glioma grades. This finding is not in accordance with the findings of our previous  and recent  studies in newly diagnosed gliomas. Moreover, there is a significant correlation between the 18F-FLT uptake and the Ki-67 labeling index, but the correlation coefficient (r = 0.50) was lower compared with the findings of our previous (r = 0.89)  and recent (r = 0.81)  studies in newly diagnosed gliomas. These discrepancies might be due to the small number of patients and mixture of primary and recurrent cases. Radiotherapy used as an adjuvant treatment for malignant gliomas may cause loosening of the endothelial tight junctions, vascular leakage, or endothelial cell death and thus can increase vascular permeability not only in the BBB but also in the blood-tumor barrier . Besides increased cell proliferation in recurrent tumors, treatment-induced breakdown of the BBB and blood-tumor barrier might contribute to the degree of 18F-FLT in the tumor. This may also be the case in 11C-4DST.
Although the short physical half-life of 11C is a significant limitation for routine clinical use, 11C-4DST has benefits with regard to lower radiation burden and diagnosis using multiple tracers in 1 day. An alternative thymidine analogue labeled with a longer half-life isotope that can be incorporated into DNA synthesis is applied`easibly for clinical use and might provide additional and alternative information. As 11C-4DST uptake represents the whole DNA synthesis process, 11C-4DST PET might be superior for evaluating treatment response and predicting prognosis compared to other tracers in patients with brain gliomas.
The uptake pattern and uptake value of 11C-4DST in the tumor are similar to those of 18F-FLT, and both nucleoside tracers might be BBB dependent. Although no superiority was found in 11C-4DST over 18F-FLT in the detection of tumors and in the evaluation of cell proliferation, we consider that 11C-4DST is useful for the imaging of human brain gliomas with PET. Further studies are necessary to examine the usefulness of 11C-4DST for clinical application in evaluating treatment response and predicting prognosis.
This study was supported by a Grant-in-Aid for Scientific Research (B) 26293324 from the Japan Society for the Promotion of Science. We gratefully acknowledge the excellent technical support of the PET radiological technologist at our hospital.
YT, KM, NK, and JT participated in the design of the study and performed the statistical analysis. Data acquisition and data analysis were performed by YY and YN. JT helped to synthesize 11C-4DST. The manuscript was prepared by YT and NK. YN and TT conceived of the study and participated in its design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.


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Wenstrom Bible Ministries will not be conducting weekday services Tuesday April 23, Thursday April 25, Tuesday April 30 and Thursday May 2. We will resume our weekday services and our series on the book of Haggai Tuesday May 7. Please note our Sunday services will not be interrupted.


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Live in Los Gatos blog
A resource for folks living in or moving to Los Gatos, by Mary Pope-Handy
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Vasona Park's Fantasy of Lights (Light Festival)
November 1, 2021 November 1, 2021 Mary Pope-Handy
The 23rd annual Fantasy of Lights show at Vasona Lake County Park begins soon! Occasionally people call me to ask about it – please note that I do not run the event – I am only posting information about it. Full info can be found on the county's park website, linked below.
23rd annual Fantasy of Lights: get your tickets now, they sell out fast! Entry with prepaid tickets only!
When: The Fantasy of Lights
Walk-thru Weekend Dec 4 & 5, 2021 from 4 to 9 pm
Drive-thru Nights Dec 7 – 30, 2021
As always, the Fantasy of Lights is closed on Christmas Day (Dec 25).
Where: Vasona Lake County Park, 333 Blossom Hill Road (near University Avenue) Los Gatos, CA
How much: Tickets must be purchased in advance available online through EventBrite.
Walk through cost is $10 for ages 13 and up, $5 for ages 4 – 12, and free for 3 and under
Drive through cost is $20 – per vehicle. One household per vehicle!
Please visit the Santa Clara County Parks page for the Fantasy of Lights to get more information and updates on this event.
Please check the county's page for this event (bring a mask!).
More questions? PLEASE do NOT call me about this event. Please contact the SCC Parks Dept and check out their website for the Fantasy of Lights! The Vasona phone number is (408) 355-2201.
Please visit Live in Los Gatos for year round events, neighborhood information, photos around the town, interesting real estate market data, haunted places and the occasional historical tidbit.
Los Gatos is a wonderful place to visit during the holidays, but it's also a great place to live year round! If you are interested in buying a home in Los Gatos (or selling one), please contact me, Mary Pope-Handy. I'm both a Realtor in town and a resident myself, working full time in helping nice folks to buy & sell homes here and throughout the west valley.
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Categories Events, LG Lifestyle, Los Gatos Events, Los Gatos Parks, Parks in Los Gatos, Visiting Los Gatos Tags Cost, Date, Fantasy Of Lights, Holiday, Los Gatos, Park, Vasona
The Cornucopia Fruit Stand
October 20, 2021 October 15, 2021 Mary Pope-Handy
Edit (10/15/2021): Sadly, Cornucopia looks like it is permanently closed. What may have been Los Gatos' last permanent farm stand closed it's doors this winter after tree sales and the property sold in February. On Facebook the family has bid farewell with a "Thank You" with many more from patrons and business associates in reply. The large property so close to El Camino and Netflix will likely be intended for development. We will miss you, Cornucopia Fruit Stand!
Original Article (10/27/2019):
Perched at a slight angle on Winchester Boulevard, the Cornucopia Fruit Stand is a celebrated remnant of the town's agricultural heritage that you can still enjoy. Established in 1976, Cornucopia continues selling seasonal produce almost year-round. Spring and summer mean fresh fruit and veggies, and for the holidays it's a great spot for top-grade Christmas trees.
This weekend my family and I stopped by the Cornucopia Fruit Stand in Los Gatos to stock up on some Halloween pumpkins. If you're still looking for a squash for your porch, Cornucopia has a plethora – from Sugar Pie Pumpkins for carving to the fancy Cinderella pumpkins! And what would a pumpkin patch be without some festivity? Los Gatos' Original Great Pumpkin Patch (as they proudly call it) is decorated with painted pumpkins (also for sale), instagrammable photo spots, friendly scare crows, and classic Halloween stand-in cutouts for the kids.
Categories Great Places in Los Gatos, LG Lifestyle, Los Gatos Businesses, Visiting Los Gatos Tags Halloween, Los Gatos Business, pumpkin, pumpkin patch, pumpkins
The Promenade: Strolling Downtown Los Gatos with Live Music this Summer! 7/1 – 8/12, 2021
August 12, 2021 June 28, 2021 Clair Handy
Los Gatos Chamber of Commerce poster for the Promenade!
The Los Gatos Chamber of Commerce invites the community to celebrate summer together with free live music all summer!
Thursday Promenades in Downtown Los Gatos
There's a party in downtown every Thursday Promenade beginning this week! Every Thursday evening, 3pm to 8pm from July 1st to August 12th, the stretch of North Santa Cruz Avenue in downtown Los Gatos between Main St and Bachman (that's from Dolce Spazio to Andalé for the foodies) will transform into "the promenade." The street will be open to foot traffic, and two stages will bookend the promenade with live musical entertainment!
Bands will begin performances at 4:30pm on the North Stage (Bachman), and at 5:30pm on the South Stage (Main), with entertainment from a different group each week. See the lineup (and any changes) on the Los Gatos Chamber of Commerce calendar, the Thursday Promenades page linked above, or Camber of Commerce social media pages.
Drivers, plan to reroute around this stretch of N. Santa Cruz Ave on Thursday nights. While there is usually plenty of parking along the old rail line behind the shops, it tends to fill up with festival traffic, so schedule in some extra time for parking. If you're coming for the event, consider traveling by bike, or using a ridesharing service if you plan on patronizing any of the bars or brewery!
As someone who regularly attends free summer concerts in Los Gatos, which were mostly canceled earlier this year (and the Fiesta de Arts / Wine Walk postponed until September), the Promenade is music to my ears!
So invite your friends to eat, drink, play, and stroll the night away!
Musical lineup, taken from the Los Gatos Chamber of Commerce Facebook page. Click to see the original post.
Categories Downtown Los Gatos, Events, Food & Drink, Irrelevant Fun, LG Lifestyle, Los Gatos Art & Entertainment, Los Gatos Businesses, Los Gatos Events, Los Gatos Restaurants, Cafes, Bars, Wineries, Maps of Los Gatos, Pampered in Los Gatos, Shopping, Visiting Los Gatos Tags Community Event, Entertainment, Event, Events, Free Event, free music, Free Music Concerts, Free Music Series, Free Musical Concerts, Fun, Los Gatos Events, Los Gatos Free Music, Los Gatos Music, Music, Musical Series
JCO'S Place for Fine Art
April 3, 2019 February 7, 2019 Mary Pope-Handy
Love fine art? A fun place to stop in and get tempted by the work of creative people can be found in downtown Los Gatos at JCO'S Place, located on University Avenue (address is near the bottom of this article).
A few years back, when JCO's was located on N Santa Cruz Avenue near the theater, I was strolling past this gallery with my daughter, plus my visiting niece and nephew, who hail from Boston, and noticed some beautiful, over-sized paintings. I did a double take when I saw one of Tom Brady, # 12, as you don't normally find a lot of Patriots art here in Los Gatos. Stepping in, that wasn't the only piece from the Northeast. It was a surprising find!
Not everything is Brady, Patriots, and Boston – there was plenty of other football art on display to keep in the theme of the game for this season and the multiple celebrations of SuperBowl 50 here in Silicon Valley. To get a better sense of the diverse offerings, check out the blog portion of her website: http://www.jcosplace.com/art-blog .
Why the Tom Brady and Patriots focus? I wish it were because they would have been in an upcoming game. Instead, it turns out that the proprietor of the store, Julie Jenkins, hails from Boston. I had a fun talk with her. She is very warm and welcoming, and I'd love to come back to see what she brings in next.
The shop also had an artist painting and visible from the window, Nick Brown, a very talented guy. What I saw looked quite a bit like our eastern foothills, but I didn't get a chance to talk much as my younger relatives were ready to continue our walk through downtown Los Gatos.
Next time you are out for fun in downtown LG, take a few minutes and stop by JCO's Place. I think you will enjoy it!
Julie Jenkins
805 University Avenue #E • Los Gatos CA 95032
Hours: As of this writing, closed or by appointment Mon and Tues. Check the most current hours on the site: http://www.jcosplace.com/visit.html
JCOSPLACE.com
Categories Los Gatos Art & Entertainment, Los Gatos Businesses, Pampered in Los Gatos, Visiting Los Gatos Tags Fine Art, JCO's Place, Julie Jenkins, Los Gatos, N Santa Cruz, painting, Patriots, Tom Brady
Los Gatos Historic Home Tour
February 16, 2018 February 12, 2018 Mary Pope-Handy
The annual Los Gatos historic home tour returns to town for one day only on April 21st, 2018, and tickets will be available to purchase online as soon as February 26th. Sponsored by the New Museum of Los Gatos (NUMU), the annual event showcases beautiful Los Gatos properties from different eras and frequently their gardens, too.
The focus of this 23rd annual Los Gatos historic home tour will be the lovely Johnson Avenue neighborhood!
Seven houses will be on display for tour-goers. The medley of event features also includes some live music and vintage cars for show on the street.
The NUMU site offers this teaser about the Los Gatos historic home tour: "The program guide provided to all tour goers includes historical and architectural information on the featured homes as well as back stories and trivia on the history of the Johnson Avenue neighborhood, including the locations of the former sites of a private zoo of exotic animals, and the baseball field where Los Gatan Hal Chase practiced. (He was later implicated in the Black Sox scandal of 1919.)"
Sunday evening, in lieu of the usual second tour day is a new event, entitled A Bigger Bash.
Please visit the link below or click on the image at the right to get all of the details and to purchase your advance tickets (more costly if you wait to the day of the event).
http://www.numulosgatos.org/hht
Please also see this list of downtown, central, and historic Los Gatos neighborhoods
Categories Los Gatos Events, Los Gatos History, Visiting Los Gatos Tags Events, historic home tour, Los Gatos, real estate, volunteer
Los Gatos historical walking tour app: LOST GATOS
July 8, 2016 Mary Pope-Handy
Michael Kane as Mountain Charlie in the 2007 Historic Walking Tour in Los Gatos
Locals may remember that a few years back, there was a wonderful "Los Gatos History Walk" put on every year or so. Town residents would don garments from a bygone era and take on the persona of legendary Los Gatos figures for a few hours. Both fun and educational, it provided a sense of the town's past – both the buildings and the people's. It was absolutely wonderful while we had it.
Today, there's an app for that! It's called Discover LOST Gatos and as of this writing, there are 3 different tours:
The Heart of Los Gatos (approximately a 35 minute walking tour with 12 stops)
Los Gatos: The Gem City (a 45 minute walk with 12 stops
The Cradle of Los Gatos (50 minute stroll with 13 stops)
The Mercury News did a nice article on this and will fill in the details on who's behind this wonderful idea.
http://www.mercurynews.com/los-gatos/ci_30098778/los-gatos-discover-lost-gatos
As for me, I just downloaded it to my phone and look forward to getting to know our beautiful town a little more. You can find it online wherever you get your phone's apps – just search for LOST Gatos.
Categories LG Lifestyle, Los Gatos History, Visiting Los Gatos Tags app, history tour, history walk, Los Gatos History, Lost Gatos, Michael Kane
Chocolate Dream Box – a Los Gatos Treasure!
August 28, 2015 Mary Pope-Handy
Chocolate Dream Box has been a part of the Los Gatos landscape, in one location or another, for many years. It first opened in downtown along North Santa Cruz Avenue, then was located on Los Gatos Boulevard and Blossom Hill Road at King's Court Shopping Center, and now calls The Downing Center (at the corner of Union & Los Gatos-Almaden Road) home.
Today I stopped in to see the new shop, to buy a gourmet chocolate gift and see how the owner, Holly Westbrook, and staff are doing. I'd blogged about it in 2011, back at the old location, and thought an update was in order, too, for their new location (and my blog's new location).
Things seem to be great overall. The new store is bigger and brighter than the former one was and feels comfortably roomy. The decor is always beautiful, with a hint of Europe here and there to remind visitors of the inspiration.
What's selling? Old favorites, such as the dark and milk chocolate cats, can still be found, and as always, there's an abundance of specialty candies and exceptionally beautiful and tasty truffles. There are non-candy gift items too, pretty affordably priced also. Today I saw a pewter fleur de lis that was quite tempting…
The move was, of course, a lot of work for them, and if you're local, you know that they hadn't wanted to move but got forced out by their former landlord. Any business owner would be concerned about losing customers with a new location, but I imagine in time everyone will find their way to the new shop – it's only 1.5 miles away from the old one. An unexpected element, though, happened too – the Yelp reviews from the old location could not transfer to the new one – ouch! If you are a fan, cruise on over there and give them a shout out. I did that today; it's great to support our local Los Gatos businesses!
Truffles, truffles, and more truffles. The biggest problem with visiting the Chocolate Dream Box is figuring out which one(s) to buy!
Categories LG Lifestyle, Los Gatos Businesses, Pampered in Los Gatos, Relocating to Los Gatos, Visiting Los Gatos Tags Chocolate, Downing Center, European chocolate, Gifts, specialty, truffles
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redpajama_set_name: RedPajamaCommonCrawl


At least 2,018 terrorists have been "neutralized" in northwestern Syria's Afrin since Operation Olive Branch was launched on Jan. 20, Turkish Armed Forces announced Sunday, with eight more villages brought under control.
A Turkish soldier has fallen Saturday during operations targeting YPG/PKK and Daesh terrorists, a Turkish Armed Forces statement said Sunday, without giving further information. So far, 33 Turkish soldiers have been killed in action during the operation.
On Sunday, Turkish forces and Free Syrian Army (FSA) liberated eight more villages from YPG/PKK terrorists Saturday as part of the Operation Olive Branch in Afrin.
The villages of Sarmalik, Shaykh Muhammadli, Wilakli, Dudu, Kavanda, Maydan Akbis and Bandirak, located northwest of Afrin town center, and the village Umranli and a nearby YPG/PKK training base, located northeast, have been cleared of the terrorists.
A violent clash took place between the FSA forces and YPG/PKK terrorists near the training base located close to the town of Sharan.
After neutralizing the terrorists, the FSA troops captured and entered the area which was used by the terrorists as an armed training camp.
The terrorists had shaped the upper part of a rock found at the camp as a human head, depicting the terror group's leader.
They had also written "APO" on the rock, referring to the convicted head of the terrorist PKK.
The FSA forces destroyed the rock after they captured the camp. They also found scores of pennants and documents of the terror group.
Since the launch of the operation, Turkish military and the FSA liberated 112 locations including one of Afrin's five towns, 83 villages, six smaller villages 20 strategic mountains and hills and two YPG/PKK bases.
The TSK along with the FSA launched Operation Olive Branch in Afrin targeting the PKK terror group's Syrian affiliates the Democratic Union Party (PYD) and its armed wing the People's Protection Units (YPG) as well as remaining Daesh elements in the region.
The military also said only terror targets are being destroyed and "utmost care" is being taken to avoid harming civilians.


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Searching for Diana
Daniel Gawthrop|2002 September 17|Latest
Not long ago, I published a lousy article in the newspaper I work for in Bangkok. That's quite an admission to make. Like most writers, I invest a lot of ego and presumptions-of -authority-and-relevance into my work. So allow me to qualify that self-judgment: it wasn't a badly written piece, or an egregiously stupid one. But it was plagued by a sentimental tone bordering on the creepy, a lack of critical bite on a subject that demanded more incisive thinking, and no insight into the ambivalence I was obviously feeling about the subject. But because no one at the features desk challenged me on these points, the article was published as written.
The piece was a brief essay on the occasion of jazz superstar Diana Krall's first concert in Bangkok. The show had taken place five days earlier but, because of our section deadlines, The Nation was unable to print a review of it any earlier and the Bangkok Post beat us to it by three days. So, instead of offering the standard wrap-up of the concert and how Krall was received by her Thai audience—which would have been very old news by then—I chose instead to focus on my memories of Diana Krall from our youth in Nanaimo, BC. I talked about how Krall and my younger sister Lise were in the same class at elementary school and worked at the same restaurant as teenagers. And I described how every mention of Diana Krall, the sight of her photo or the sound of her voice reminded me of my sister because she and Lise were almost exactly the same age, were both confident young women and, apart from hair colour, shared a similar appearance. This recognition was a haunting of sorts: Lise died in a drowning accident at 19 and will never reach her potential the way Krall has. So Krall's celebrity is, for me, a constant reminder of my sister's snuffed-out narrative. Until that concert in Bangkok, I wrote, I hadn't seen Diana Krall in person for 20 years, when Lise was still alive and the two of them were working in that restaurant together.
Nothing wrong with a bit of personal memoir, as far as it goes. But then I wrote this:
When I finally saw Diana Krall again, two decades later in another hemisphere – after all the Juno and Grammy awards, the concert for US president Bill Clinton, the hobnobbing with Tony Bennett and Oscar Peterson, the multiple film score credits, and the raves by everyone from Harrison Ford and Sarah Jessica Parker to Elton John and Sting—it was hard to separate my critical reaction to her concert from those memories of Nanaimo and all the "what if?"s about Lise.
"Hard to separate my critical reaction"? Well, that's a cop-out. At the very least, I could have used "those memories of Nanaimo" as a departure for further reflection rather than as a reason to shut down my critical faculties. Instead, I went on to write four paragraphs of standard review-ese about the concert—recycled fluff about Diana Krall's prowess as an interpreter of pop jazz standards, plus an apology for the time pressure she was under after rebooking her Asian tour due to her mother's recent death from cancer—followed by a brief description of a post-concert party that Krall couldn't wait to get away from. Finally, this rather lame clincher: If Lise were alive today, I found myself wondering, would she want to trade places with Diana at that moment?"
The following is how the piece should have been written.
"Back in high school," Diana Krall told her Bangkok audience halfway through a sold-out show in the sparkling ballroom of the Queen Sirikit Convention Centre, "I never imagined I would end up here." Well, that makes two of us.
Before her appearance in the Kingdom as a Grammy award-winning international superstar, the last time I had seen Diana Krall in person she was playing the piano at the local steak-and-brew in Nanaimo, paying her career dues as an ambitious 17-year-old. She was a big hit with the weekend crowd of cigar-chomping bank managers and timber executives, whom she serenaded with lively renditions of Fats Waller and Cole Porter tunes.
Back then, no one who came from Nanaimo ever became world-famous. A coal mining boomtown in the late-19th and early 20th centuries, Nanaimo was an anonymous little seaside truckstop on the West coast where nothing really happened. During the 1970s, it was a fishing and lumber town whose biggest employer was a pulp mill. Although a handful of novelists like Jack Hodgins and Anne Cameron tapped into their muses from its shores, it wasn't exactly a cultural Left Bank. The "Hub City" was known mainly for its annual bathtub race to Vancouver, its boxing fights, and its colourful mayor Frank Ney – a lovable drunk who once refused to fund an arts centre because, as he told my mother, "the people prefer corn to culture". How could a jazz musician growing up in such an environment ever amount to much more than a successful nightclub act if she didn't write her own material or invent some new "fusion" genre?
Obviously, the gal had talent. There are female jazz singers and female jazz pianists, but few who combine the two talents so effortlessly. Over the years, the smooth, dulcet tones of Diana Krall's adolescent voice matured into the rich, sultry croon of a torch song diva—a sound like Barbara Stanwyck cloned with Julie London. It was an elegant and sexy voice, with romantic cadences and catchy phrasing that were right up there with Sinatra's. On the piano, she displayed all the form that's required of a top-flight jazz musician: she had a great instinct for improvisation, impeccable timing, and a sense of arrangement that complemented her fellow musicians, making her a dream to work with.
But that wasn't all she had going for her. In addition to talent, Diana Krall had physical beauty. I don't want to go overboard here and ascribe totally cynical motives to her record label's marketing department. But this woman is a glamorous, blonde Diana goddess the world hasn't seen since, well, the last glamorous, blonde Diana goddess (you know, the one who's no longer with us). That's why her face is prominently displayed on her latest album, "The Look of Love", as it is on all the others—its every feature airbrushed to perfection. She is indeed a princess; the "total package", as a music industry exec might say.
Diana Krall, her publicity tells us, was "a four-year veteran of piano lessons by age nine". That was the same year, just across the hall from her at Cilaire Elementary School, that I was giving up on musical instruments because my parents rejected my choice of the trumpet. Later, while I was wanking my way through high school by wasting my summer job earnings on rock and roll albums that would end up in garage sale trash heaps, Diana Krall was setting herself up for a scholarship at the Berkelee Music School.
After being "discovered" at the restaurant in Nanaimo, Krall's musical apprenticeship lasted nearly a decade. She moved to New York, met everyone who was anyone in the jazz world, and slowly worked her way to a recording career. In the last decade, she has produced five albums. All of them are lush recordings with rich production values; they're perfect to play at the end of a long date when you just want to sit down with your partner du jour and knock back a couple of whisky sodas before collapsing on the couch for the night.
The only criticism I'd heard of Diana Krall before she showed up in Bangkok was that all of her songs sounded the same. And there is a bit of truth to this. When she first hit the stage that night, plodding her way through "Love Being There", then followed that with an a cappella version of Lawrence/Altman's "All or Nothing at All", there was a strange aloofness about her demeanor. Her playing and singing were flawless, as usual, but there were odd moments of detachment from her audience that suggested boredom with the material. (My Thai companion at the concert, a colleague from The Nation, was somewhat harsher in his verdict: he thought she sounded "cold and soulless".)
I also had to wonder at Krall's choice—or was it someone else's?—of "The Look of Love" as the title track for the new album. From a sales standpoint, it made sense: the pop music world had been going through a Burt Bacharach renaissance that's dragged on for a couple of years. "The Look of Love" was released the same year that big retrospectives on Burt came out, including tribute compilations and boxed set albums by the cocktail king himself. Lots of other artists have been jumping on the Burt bandwagon, shamelessly pandering to the nostalgia industry. Jose Padilla, for one, couldn't get enough of "The Look of Love". He included Dusty Springfield's version three years ago on "Café Del Mar: Volume Six", a jazz pop/fusion series he produced. Then last year he included N'Dea Davenport's version on his own "Navigator".
Surely this song has long since passed the point of parody worthy of the karaoke lounge set. Like "Can't Take My Eyes Off Of You" ("You're Just Too Good To Be True")–one of those songs that no serious artist can perform without stifling the gag reflex. So why would Krall, a musician's musician with obvious respect for jazz tradition, one who is so much more interesting and creative when she attempts something like "Take the 'A' Train", bother singing it—much less make it the title track of her new album?
My hunch is that a lot of the choices she makes about her music are not her own. These days, it seems, modern jazz has become the only pop music genre in which it is possible to achieve international stardom through interpretation rather than song-writing credits. Once you've eliminated the fight to push your own material through a record company, and then, once you've subjected yourself to the full arsenal of the company's publicity department, then all subsequent claims of artistic freedom become instantly suspect. As an artist for Verve/Universal, which belongs to Sony, Diana Krall would not be where she is today if she were a rebel-rousing boat-rocker who insisted on total control of her own material. And that, for me, raises the question of how much of this torch song persona she puts out to the world is really her own and how much of it is manufactured for marketing purposes; to what extent has she become her own person—an autonomous individual artist expressing herself through her medium, as opposed to a tool of the music industry?
I suspect that, despite all the superficial glamour, the name-dropping and the New York City postal code, there's probably a lot of that Girl Next Door from Nanaimo about her. It was certainly in evidence at the post-concert reception organised in her honour. Krall seemed dazed when she walked through the door to find a large crowd of people and a lavish spread of canapes and whiskey laid out by sponsor Chivas Regal – as if no one had told her in advance. When she was invited onstage to address her fans and have her picture taken with a few of them, there was a moment of excruciating silence as the emcee waited for Krall to cross the floor and join her onstage.
"Oh," the singer said, sounding exasperated, "nobody told me about this." Such glad-handing publicity stunts are the bane of every music superstar's existence; they are to be tolerated, not embraced. But in Thailand, a country whose people treat Western pop stars like royalty and are delighted by any contact with them, a little forbearance can go a long way. Thai culture places very high importance on the ability to be polite and show humility when people place themselves below you in public; it's a major breach of protocol when you fail to do so. Most celebrity visitors to The Land of Smiles do enough research on the basics before arriving to avoid diplomatic embarrassment while they're here. But Krall, who was clearly showing the effects of cramming 22 shows and 12 countries into 37 days, didn't have it together.
When she arrived onstage, the perky hostess from TV Channel 11 showered her with compliments on her performance and expressed regret that Krall had flown in only for one night and was leaving the next day. When would she be back to see more of this country and meet more of its people?
"Whenever you'll have me," Krall replied, offering nothing more. There were a few more failed attempts to get the singer to connect with the crowd—mostly Thai yuppies who had paid several thousand baht for the privilege of having their photo taken with the star—before the emcee lobbed a softie. "Do you have any message for your Thai fans?" she was asked.
"Oh, just what I said onstage—that I'm really happy to be here and that I want to thank the fans in Bangkok for such a great reception." Period.
Oh dear: a canned response. Krall sounded very much like a player being interviewed on Hockey Night in Canada. There were smiles all around, and scattered bits of polite applause, but it was clear to everyone in the room—perhaps even the guest of honour herself—that she was bombing big-time, and the emcee had little choice but to move things along and get to the photo session. After enduring two or three groups of "lucky winners" who posed with her, the star of the show began making her way through a procession of well-wishers, clearly heading for the exit. After less than ten minutes, the "meet-and-greet" Diana Krall love-in was over.
I swallowed my complimentary Chivas Regal and shrugged at my missed opportunity to surprise a hometown girl in Bangkok.
September 17, 2002	2,352 words
Daniel Gawthrop is a Vancouver writer, and the author of several books, the most recent of which is "The Trial of Pope Benedict: Joseph Ratzinger and the Vatican's Assault on Reason, Compassion and Human Dignity" (Arsenal Pulp, 2013).
More from Daniel Gawthrop:
After the Asshole Apocalypse
How to keep thinking during and after the Apocalypse. Dan Gawthrop has a few practical suggestions. Read more… →
Xenophobic nationalism: Myanmar's curse
Dan Gawthrop on genocide-in-progress. The Rohingya crisis in Myanmar. Read more… →
Omar Khadr: Window on the Canadian Soul
Thinking through the controversy over a child soldier. Read more… →
Nanaimo Pride: The Resistance of Memory
Nanaimo, B.C. held its first Pride Parade. But when? Read more… →
An Independent Newsroom Where Self-Censorship Rules
Dan Gawthrop reports from Burma. The post-dictatorship press looks "independent," but what about the big story on which it is tip-toeing the government line? Read more… →
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The Wall Street Journal reports that Baidu is eyeing an IPO for iQiyi that could value the streaming platform at a cool $5 billion.
In what may shape up to be the ultimate win-win for Baidu (NASDAQ:BIDU) and its critics, it seems as if we'll be getting an IPO next year of Baidu's popular yet profitless video-streaming platform. The Wall Street Journal is being told the Chinese dot-com darling is considering a U.S. or Hong Kong debut for iQiyi, a move that would raise $1 billion for Baidu's majority-owned business and value iQiyi at $5 billion.
This is good news all around, but it would come as sweet vindication to the activists who earlier this year were accusing Baidu insiders of trying to practically steal the streaming hub. In February, Baidu CEO Robin Li and iQiyi CEO Yu Gong led a group that planned to take iQiyi private. The proposed $2.8 billion deal would've translated into a roughly $2.25 billion pre-tax payday for Baidu's 80.5% position.
Baidu stock rallied at the time. As prolific as iQiyi was, monetizing chunky video streams is a tall order in China. With iQiyi in the red it was weighing down Baidu's higher margin search engine business. It would've been the best of both worlds. Baidu would be able to move a profit-sucking subsidiary off of its books and collect a fat check in the process.
It didn't happen. Some started to argue that $2.8 billion wasn't enough for iQiyi. Baidu investor Acacia Partners would go on to pen an open letter to Li, suggesting that the price was too low and the transaction would be a conflict of interest. iQiyi rival Youku Tudou had been acquired in a $4.8 billion deal that closed a few months earlier, and with Youku Tudou and iQiyi putting out rival statements claiming superiority in the past, Acacia Partners wondered why it was punching out for $2 billion less than its biggest competitor.
Li and Gong officially withdrew the offer to Baidu's board to take iQiyi private just days after the open letter went out. Baidu's press release would point out that the two sides failed to agree on the transaction structure and purchase price, and it seemed likely that activist pressure played a part. Baidu's stock languished after the privatization deal fell apart, but an IPO that values iQiyi at a lot more than the $2.8 billion proposed in the deal to go private vindicates the activism and benefits Baidu and its stakeholders.
The market cheered last year's deal to take iQiyi private at $2.8 billion. It will naturally love the plan to take iQiyi public at $5 billion, even if $1 billion of that value comes in the form of shareholders buying into the offering.
Baidu can use the favorable attention. The stock has languished since it had to curb health-related ads following regulatory mandates earlier this year, a blow to both ends of Baidu's income statement given the high-margin nature of those paid search spots. Video streaming is important to Baidu, but clearly not profitable. Baidu has been investing in new businesses that may not pay off right away, and it now has an opportunity to turn a big drain on its bottom line into a money maker. It's the right call if the reports hold up and the market climate is conducive to making the IPO happen.


text:
Les Hynobiidae sont une famille d'urodèles. Elle a été décrite par le zoologiste Edward Drinker Cope (1840-1897) en 1859.

Répartition
Les espèces de ses dix genres se rencontrent en Russie, en Asie centrale, en Iran et en Asie de l'Est.

Liste des genres
Selon  :
 sous-famille Hynobiinae Cope, 1859
 genre Afghanodon Dubois & Raffaëlli, 2012
 genre Batrachuperus Boulenger, 1878
 genre Hynobius Tschudi, 1838
 genre Iranodon Dubois & Raffaëlli, 2012
 genre Liua Zhao & Hu, 1983
 genre Pachyhynobius Fei, Qu, & Wu, 1983
 genre Pseudohynobius Fei & Yang, 1983
 genre Ranodon Kessler, 1866
 genre Salamandrella Dybowski, 1870
 sous-famille Onychodactylinae Dubois & Raffaëlli, 2012
 genre Onychodactylus Tschudi, 1838
et les genres fossiles :
 †Iridotriton Evans, Lally, Chure, Elder & Maisano, 2005
 †Liaoxitriton Dong & Wang, 1998

Publication originale
 Cope, 1859 : On the primary divisions of the Salamandridae, with descriptions of two new species. Proceedings of the Academy of Natural Sciences of Philadelphia, ,  (texte intégral).

Liens externes

Notes et références

Hynobiidae
Famille d'urodèles (nom scientifique)

redpajama_set_name: RedPajamaWikipedia


text:
Consider building your businesses around your domain name.
by Brad Huss | May 9, 2014 | Branding, Facebook, Google+, Instagram, LinkedIn, Pinterest, Social Media, Twitter, Web | 0 comments
In June, Shaun McGowan's business, Beep.com.au, was turning over $60 million. Five months later the company has grown by 60%, now exceeding $100 million in turnover, through one simple change – the domain name.
McGowan purchased a new, premium domain name CarLoans.com.au in June and since then the business's click throughs have increased, its marketing spend has reduced and turnover has increased by $40 million.
Speaking to SmartCompany,McGowan says the change has made a "massive" impact.
"There is a natural assumption the biggest, oldest companies have the premium generic domain names," he says.
"In terms of the domain name investment, the name paid itself back within four months.
McGowan says the benefits of the new name have been multi-tiered, but the number one change has been people's perception of the business.
"People assume it's the biggest and the best car loans business now," he says.
"The benefit of a premium domain name is its very descriptive – people know straight away what your business does."
McGowan took almost two years to acquire the name from a gentleman who bought it 15 years ago and says it's since improved both the front and back-end of the business.
"We noticed the impact the very next day. The moment we launched CarLoans, we had a 35% drop in our AdWord spend the next day," he says.
"A lot of our inquiries are driven through AdWords, but we're now getting the same number of leads for much less. Our click-through rate went up and our conversion rate alone has increased by 30%."
The impact of premium domain names on online advertising click-throughs seen by McGowan was also noted in a UK study by Memorable Domains.
The report found "ads featuring a generic domain name with an exact match to the product (ElectricBicylces.co.uk) performed significantly better than identical ads featuring an alternative generic (YourBikes.co.uk) or non-generic (InAHurry.co.uk) domain".
The study found ElectricBicycles.co.uk ads produced 45% more click throughs than YourBikes.co.uk and 105% more click throughs than InAHurry.co.uk ads.
McGowan says while premium domain names can be expensive, it's a worthwhile investment.
"Our inquiry rate increased massively. The cost-per-click came down and we catapulted through the search engine rankings, and that was just our front-end improvements," he says.
"We've also noticed when the sales consultants are talking to the customers our name now is now seen as the authority in car loans because of its natural association with CarSales. Our settlements and conversion rates from us speaking to customers increase, customers would give us more information from the outset and they'd speak to us on the phone for longer."
McGowan has also capitalised on people's natural association of the name with CarSales by designing the CarLoans website and its processes to be similar to those found on the CarSales site.
McGowan says people should consider building their businesses around domain names.
"The problem most have in today's world is they decide on their business and then go looking for a name. They should find the domain name and then build the business around it," he says.
"When you can, you should invest in the best possible name and spend the most money that you can afford. Relating it back to the retail world, think about it like a store location. Having a premium domain name is the equivalent of buying the best shop on the best street with the best foot traffic."
originally published November 5, 2013 : http://www.smartcompany.com.au/technology/online/34431-from-beep-to-carloans-how-a-domain-name-change-resulted-in-a-40-million-turnover-boost.html#


14 people believed to be Chekosis have been arrested by the police in the Saboba district of the Northern Region.
They were arrested in one of the villages in the area on suspicion of a planned attack on a Konkomba community.
The suspects are expected to be transferred to Tamale.
The violence at Chereponi was ignited last month when unknown assailants opened fire on Nawieku, a Chokosi community in the district, injuring one person.
In late March 2019, six persons out of eight suspects who were arrested in connection with the violence between the Chekosis and Konkombas were remanded into police custody.
Three persons lost their lives and more than 20 communities were burnt in the latest violence.
Some students of the Chereponi Senior High School fled the school premises following clashes in the town.
The Overload of Dagbon, Yaa Naa Mahama Abukari II subsequently sent a delegation to the troubled Chereponi and Saboba districts to seek for peace.


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TruHealth Solution's partner with business helping them develop their health and safety policy and procedures as well as recruiting, testing and managing the health and safety of their employees.
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Drug Deaths in Australia at Record High
Truhealth Solutions
If you think that record high drug deaths in Australia should be outside your company's sphere of concern, think again.
A recent article in The Age by Aisha Dow reports the alarming new figures of drug deaths in Australia. There is a new breed of killer drugs that are claiming more lives than heroin or speed.
Benzodiazepines: Prescription drugs that kill
Dow refers to a new report published by the Penington Institute. The report finds that legal pharmaceutical painkillers are the leading killer of many Australians. With many deaths due to a lethal combination of painkillers, sleeping pills, and alcohol.
As sedatives and sleeping pills become more and more popular in Australia, drug related deaths will only increase.
Benzodiazepines are widely prescribed in Australia for a wide variety of problems. These include conditions such as anxiety, insomnia, epilepsy, alcohol withdrawal, anxiety, and some psychological disorders.
Xanax, Klonopin, Valium, Ativan — these pills are so common in Australian homes and contribute to hundreds of drug overdose deaths each year.
Even Non-Addicts Overdose
It is so easy to cross the line between prescription drug use and prescription drug abuse. In Australia, a prescription for benzodiazepines is usually only for short-term use. Anything more than a month can lead to dependence on the drug.
But what's surprising is that it is not only prescription drug addicts who overdose on opioids. According to John Ryan, the chief executive of Penington Institute, even the occasional takers, those without drug dependencies, CAN and HAVE overdosed.
The way Benzodiazepines work is that it depresses a person's respiratory system. They are tranquilisers and sedate, relax, or hypnotize the person taking them.
What makes it so dangerous, and why many people overdose, is that it slows down a person's breathing and deprives the brain of oxygen.
Hardest Hit Demographic Of Drug Deaths In Australia: Middle-Aged Australians
Australians aged 30 to 59 are the hardest hit demographic in this epidemic. In 2017, 70 percent of accidental deaths occurred in that age group.
What begins as youthful experimentation in their younger years often leads to drug use later on to cope with crises.
While a person who has never used drugs in the past have healthier coping mechanisms, those who have tried prescription drugs often resort to them in dealing with struggles.
Australians who resort to Benzodiazepines often have physical, mental, emotional struggles. Since they are legal, it easy for Australian employees to get their hands on benzodiazepines.
Another sad thing about drug overdoses is that they happen quickly. One minute the user is okay and laughing and the next he or she is gone.
Many drug users don't have an awareness of an impending death.
Record High Drug Deaths in Australia Uncovers Widespread Legal and Illegal Drug Addiction
The Penington Institute's Annual Overdose Report in 2017 exposes Australia's growing drug problem. A huge numbe of overdoses can be attributed to pharmaceutical drugs and methamphetamines.
Accidental drug overdoses claim approximately 142 deaths a month.
Heroin deaths rose to 1183 between 2012 and 2016. That's more than a twofold increase from 554 between 2002 to 2006.
Deaths from amphetamines quadrupled from 298 to 1237 and deaths from opioids rose from 55 to 746 in the same time period.
Drug toll far exceeding road toll
The death toll difference between accidental drug deaths and car accidents has never been greater.
There were 1,489 accidental deaths by drugs in 2015, significantly higher than 712 deaths by car accidents in the same year.
Drug-related deaths are now more than double the number of deaths caused by car accidents.
Mr. Ryan warns that if Australia doesn't do anything about the increasing number of drug deaths, we are going down the same path as the United States, where approximately 30,000 opioid-caused deaths were recorded in 2017.
Therefore, our country should respond to the surge in drug deaths by providing easy access to drug treatment and rehabilitation.
You can read the original news story here.
As a company, do not wait for someone in your workforce to succumb to a drug overdose. For some businesses, this can be fatal. It is exceedingly difficult to spot drug addicts, even when you work side by side.
Why Testing for Prescription Drug Abuse Is Critical For Your Company Now
With the staggering number of drug deaths in Australia, it's critical to invest in testing for drug use.
Roughly 70% of Australians using and abusing illicit drugs are part of the workforce. As we have discovered, the combination of illicit and prescription drugs is a lethal one.
We see the solution as two-fold:
Do what you can to ease the stress that work may cause your employees.
Invest in a drug testing and drug safety program to increase awareness and prevent drug problems from remaining undetected until it is too late.
The impact of drug abuse is swift and often severe. Therefore, your company cannot afford to wait around. If someone is developing a prescription drug addiction, you need to know very quickly.
There's no better time to be pro-active and define a program for drug safety and drug testing at the workplace.
It is not just about saving your business, it's about protecting Australian workers and their families, too.
Highest Number of Australian Drug Deaths in Almost 20 Years (Infographic)
Smashed Trafficking Ring Highlights Size of Ice Problem In Australia
More Drivers Test Positive for Drugs than Alcohol in Australia
Truckie Intended To Drive 42 Trips High On Ice
Published On: September 29th, 2020 / Categories: TruHealth /
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Truhealth Solutions has always sought to create a better understanding of the issues around substance abuse within our unique and treasured Australian society.
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Third-party iOS camera app Camera+, which launched five years ago this month and brought a companion app to the Apple Watch this week, is known for its extensive suite of editing tools, filters, and settings that let shutterbugs customize and tinker with their images the way the pros do. Amid all that functionality, though, there's one big feature that it doesn't have.
The team considered the possibility of adding video at one point, recalls Camera+ co-founder Lisa Bettany, before deciding it would probably overwhelm the user experience. Better, they ended up deciding, to have an app that does one thing — in this case functioning as a combination camera and image editing tool — and focus on doing that well.
That's also the reason Bettany and two other Camera+ developers, Scott Meinzer and Karl von Randow, revisited their interest in video two years ago and started building a standalone video editing tool — think Camera+, except for video. The result: Their new app Vee for Video, an iOS exclusive that arrives today in the App Store.
For Bettany, who first made a name for herself as a photographer and as a key member of the Camera+ team, the release adds another to a growing string of apps with her name attached to them. In addition to Camera+, which is now up to version 6.3 and adding new features with each release, there's also MagiCam, a 2014 release that strips away some of the complexity of Camera+ to cater to users who want more of a one-touch, simpler experience. Towards the end of last year, she also released her first solo project – Poppets, a mobile game for iOS.
The game was a product of the app development company Bettany set up called CakeBytes Creative Inc. She's started another company, Medious, which is behind Vee for Video.
The idea behind Vee, she goes on, is that a user can take a batch of clips and stich them together by using a simple editor that makes it easy to drag and drop clips, add filters, trim the clips and even add a soundtrack via the user's iTunes library. Bettany says the team's starting point was a belief that "shooting and editing on mobile is broken" – that editing has, in fact, been a secondary process instead of integrated into an application that also enables shooting video.
"I was shooting videos and never watching them again," Meinzer said about why the team built Vee. "They just took up space in my camera roll, and I never went back and edited them, because it was too much work.
Among its other features, Vee includes 18 live filters, lets users shoot up to 1080p in full HD and uses the device's sensors to eliminate camera wobble. Touching the screen lets the user choose focus and exposure points, and Vee allows for sharing among all the major services at full resolution.
There's also a feature that gives the user a kind of ghostly image of their last frame, which they can use to line up the next shot. And rather than having to wait while Vee exports a video, Vee will keep going in the background if the user wants to jump to another app.


In the previous post Impress users with new visualizations in Telerik Reporting Q1 2013, we covered some of the features that the new Graph report item offers to developers who want to add data visualizations to Telerik reports. Just to recap, the new Graph report item uses the crosstab's OLAP data engine, and offers a set of new visualization capabilities which will help your users understand data quicker and make better decisions.
The Graph item uses a two-dimensional coordinate system that uniquely identifies the position of each data point (http://en.wikipedia.org/wiki/Coordinate_system). Each coordinate system consists of two reference lines called coordinate axes or just axes and an origin.
y axis - the vertical axis.
The data point in the Cartesian coordinate system is represented by an ordered pair of two coordinates (x, y).
radial axis - the axis for the radial coordinate.
The data point in the Polar coordinate system is represented by an ordered pair of two coordinates (r, ϴ).
(x, y) ⇔ (ϴ, r).
The coordinate system also defines the default appearance/style of the two axes.
The coordinate axis or simply axis represent a single dimension of the coordinate system.
Grid lines - Within the graph a grid of lines may appear to aid in the visual alignment of data. The grid can be enhanced by visually emphasizing the lines at regular or significant graduations. The emphasized lines are then called major grid lines and the remainder are minor grid lines.
Scales define how the data is projected on the corresponding axis that is how the data from the user domain is converted to coordinates.
CategoryScale - represents an ordinal scale with discrete domain like names and categories.
Bar (clustered, stacked, stacked 100%). Used for Bar, Column, Pie and Rose chart.
Line (stacked or stacked 100%). Used for for Line, Bubble, Radar line and Spider line charts.
Area (stacked or stacked 100%). Used for Area, Radar area and Spider area charts.
When the data appearing in a chart contains multiple variables, the chart may include a legend. The legend contains a list of the variables appearing in the chart and an example of their appearance. This information allows the data from each variable to be identified in the graph.
The Graph item can have one or more Titles that provides a succinct description of what the data in the graph refers to.
This is the first blog of a series where we will introduce the new Telerik Reporting Graph item powerful features.


Yay! Up early to curl hair. 2 cups of coffee. Got to church early. Adrenalin pumping. All hyped up.
Figured its not worth the effort to curl my hair so I straighten it and cake it with hair spray to fight off the Florida humidity. Was good with one cup of coffee.
My excitement energy is wearing off. I quickly get ready so I can fix a cup of coffee. I contemplate/attempt taking a nap behind stage before the morning extravaganza.
Took a nap afterwards while waiting for Steve to pick me up for a trip to run some errands. He woke me up and I was tired the rest of the day.
Getting out of bed is not very easy. I didnt finished my coffee cause i was too tired/sickfeeling. Arrived at church. Tried to memorize lines. Thankful for adrenalin that kicked in when it was show time.
The only thing motivating me to get out of bed is that thought that it is the last day and I get to come home in 5 hours and sleep.
Which I did for a whole hour.
This isn't to say I didnt enjoy my week. I truly felt blessed by what I got to do and my interactions with the kids.
But anyone who works in children's ministry, it is very tiring.


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Young looks ahead to return to Arms Park
Friday night will be something of a homecoming for Dai Young, who spent almost ten years in charge at Cardiff Blues.
Speaking ahead of the match, the Wasps Director of Rugby said,
"It will be a bit strange alright going down there and playing against my old side, but once the game gets going it's like any other."
"I expect Cardiff to name a strong side for the game because they are looking to get some momentum after a few losses and they'll see this competition as a good way to get that going again."
"Thomas is making his way in the Cardiff set-up and like any Dad I'm very proud every time he's involved in a game, but I'll congratulate him afterwards if he plays on Friday. My wife and my parents will definitely be supporting him and not Wasps this time anyway!"
Young would like to use the LV=Cup as a competition to blood a number of young and emerging Wasps players, but with five players unavailable due to international call-ups this weekend and another seven currently out with injury, his hands are tied somewhat on selection.
"We don't have the luxury of resting a lot of players to be honest. We have a very small squad and with a lot of players unavailable this weekend and with two retirements already this season, the job for me is to try and mix and match as best I can with the players who are here and fit. I will be giving a game to guys who haven't started much this season but in some positions I don't have much of a choice in giving them a break."
"These two weeks will though give a really good opportunity to those guys who have been benching or not getting in the match-day squads so far."
Lee Thomas and T Rhys Thomas are both named to start against their former team while on the bench, Matt Everard, Will Taylor and Nathan Morris will form part of the match-day squad for the first time this season, while London Wasps Academy youngster Dave Hughes is in line for his first ever senior appearance for Wasps.
London Wasps15. Elliot Daly ?14. Christian Wade ?13. Chris Bell ?12. Lee Thomas? 11. Jack Wallace ?10. Tommy Bell ?9. Jonah Holmes??
1. Simon McIntyre? 2. T Rhys Thomas? 3. Phil Swainston ?4. James Cannon ?5. Marco Wentzel (captain) ?6. Tinus Du Plessis ?7. Sam Jones ?8. Billy Vunipola??Replacements?
16. Nathan Morris?17. Tim Payne?18. Will Taylor?19. Dave Hughes?20. Matt Everard?21. Charlie Davies?22. Tom Varndell?23. Hugo Southwell
Adams sets out Six Nations goals and hails "unbelievable" playmaker Evans
Pivac pleased with Evans progress and explains back row duo's omission
Williams, Evans and Amos recalled into Wales squad for Guinness Six Nations campaign
Adams urges Cardiff Blues to continue showing attacking instinct
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▪ The Grizzwells are a family of anthropomorphic bears, drawn by Bill Schorr.
▪ Heart of the City centers on a young girl named Heart Lamarr, drawn by Mark Tatulli.
▪ Pickles focuses on retired couple Earl and Opal Pickles, drawn by Brian Crane.
▪ Soup to Nutz tells the story of the Nutz family, including three children, drawn by Rick Stromoski.
▪ Go to the comments section below and tell us which two you'd like to read every day in The Herald.
▪ Email your two choices to domara@heraldonline.com. Please write "comics vote" in the subject line.
Cast your ballot by noon Friday.