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Daily Deals: Box sets and a creepy middle grade book
JaneBook DealsDeals16 Comments
The Summit Authors Present by Various. $ .99
From the Jacket Copy:
The Summit Authors Present: Favorite Romance Themes™ is a set of six boxed sets centered around classic themes beloved by romance readers. Three new sets from this innovative collection are on sale now. Whether you love good guys, bad boys, or wounded heroes, you won't want to miss them. Each set includes four or five full-length novels from some of today's most exciting authors—all at an irresistible price: just 99c each for a limited time!
Buy all 6 Favorite Romance Themes™ boxed sets and you'll get 27 (yes, twenty-seven) bestselling, award-winning romance novels for less than $6. It's the biggest romance bargain of the summer, so hurry and grab yours today, because a deal this big can't last!
Good Guy Heroes Boxed Set (Favorite Romance Themes™)
He's the one who won't let you down. A man of honor, a peace-keeper, a hero with a heart of gold. If you need a protector, he's your man. Every woman dreams of a knight in shining armor who will keep her—and her heart—safe when the going gets tough. You'll find five of them right here. This boxed set features five full-length romance novels with "good guy" heroes by Julie Ortolon, Wendy Lindstrom, Patricia McLinn, and special guest authors Jacquie D'Alessandro and Lauren Royal.
Bad Boy Heroes Boxed Set (Favorite Romance Themes™)
Outlaws, rebels and rogues. A bad boy is the guy with a leather jacket, a killer reputation, and little regard for the rules. He's more than a little dangerous—but you just can't resist. Take a walk on the wild side with one of these men and you might lose more than your heart. This boxed set features four full-length romance novels with "bad boy" heroes by Patricia Ryan, Judith Arnold, Kathryn Shay, and special guest author Barbara Samuel.
Wounded Heroes Boxed Set (Favorite Romance Themes™)
He's a loner and a lost soul, the man who keeps to the shadows. He may have believed in love once, but not anymore. Whether his scars are physical or emotional, he's hurting and vulnerable and in need of redemption—but to get it, he'll need a Beauty with enough courage to tame the Beast. This boxed set features five full-length romance novels with "wounded" heroes by Judith Arnold, Kathryn Shay, Patricia Ryan, and special guest authors Jean Brashear and Lisa Mondello.
3 sets of books at 99c each. Authors include: Julie Ortolon, Wendy Lindstrom, Patricia McLinn, Jacquie D'Alessandro and Lauren Royal; Patricia Ryan, Judith Arnold, Kathryn Shay, and Barbara Samuel; and Judith Arnold, Kathryn Shay, Patricia Ryan, and Jean Brashear and Lisa Mondello.
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Truly Madly Yours by Rachel Gibson. $ 2.99
Where there's a will. . .
When pretty hairdresser Delaney Shaw returned home to Truly, Idaho, for the reading of her stepfather's will, she planned on paying her respects and getting out of town. But it seems the will has some unexpected stipulations-like the one that says if Delaney wants her inheritance she needs to stay put and have nothing to so with sexy Nick Allegrezza. . .for an entire year!
There's no way
Ten years ago, Nick had swept Delaney off her feet and onto his Harley, and that's when she really let her down her Hair! Back then, he was a love-'em-and-leave-'em man, and Delaney learned the hard way that she was just a fling. But Nick is as irresistible as ever. And when the ladies at Tuesday night Bingo see Nick and Delaney making after-hours whoopee through the window of a local beauty parlor, Delaney knows it's time to decide if Nick I truly, madly the man of her heart.
We've reviewed several Rachel Gibson books but not this one. I don't even remember if I read this one. Commenters?
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Shanna by Kathleen E. Woodiwiss. $ 2.99
A pact is sealed in secret behind the foreboding walls of Newgate Prison. In return for a night of unparalleled pleasure, a dashing condemned criminal consents to wed a beautiful heiress, thereby rescuing her with his name from an impending and abhorred arranged union. But in the fading echoes of hollow wedding vows, a solemn promise is broken, as a sensuous free spirit takes flight to a lush Caribbean paradise, abandoning the stranger she married to face the gallows unfulfilled.
But Ruark Beauchamp's destiny is now eternally intertwined with that of the tempestuous, intoxicating Shanna. He will be free . . . and he will find her. For no iron ever forged can imprison his resolute passion. And no hangman's noose will deny Ruark the ecstasy that is rightfully his.
This is a romance classic, but the dated themes and tropes from the 70s might be maddening.
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Doll Bones by Holly Black. $ 1.99.
A doll that may be haunted leads three friends on a thrilling adventure in this delightfully creepy novel from the New York Times bestselling cocreator of the Spiderwick Chronicles.Zach, Poppy, and Alice have been friends forever. And for almost as long, they've been playing one continuous, ever-changing game of pirates and thieves, mermaids and warriors. Ruling over all is the Great Queen, a bone-china doll cursing those who displease her.
But they are in middle school now. Zach's father pushes him to give up make-believe, and Zach quits the game. Their friendship might be over, until Poppy declares she's been having dreams about the Queen—and the ghost of a girl who will not rest until the bone-china doll is buried in her empty grave.
Zach and Alice and Poppy set off on one last adventure to lay the Queen's ghost to rest. But nothing goes according to plan, and as their adventure turns into an epic journey, creepy things begin to happen. Is the doll just a doll or something more sinister? And if there really is a ghost, will it let them go now that it has them in its clutches?
Creepy middle grade book that tackles issues of peer pressure and gender normativity.
Jane Litte is the founder of Dear Author, a lawyer, and a lover of pencil skirts. She self publishes NA and contemporaries (and publishes with Berkley and Montlake) and spends her downtime reading romances and writing about them. Her TBR pile is much larger than the one shown in the picture and not as pretty. You can reach Jane by email at jane @ dearauthor dot com
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Amy Kathryn
August 19, 2013 @ 2:15 pm
I think it is too high for the deals post, but as someone trying to replace my paperback keepers I picked up Lion's Lady by Julie Garwood when the price dropped recently to $3.99 for Kindle and Nook.
I think Truly, Madly Yours is fairly typical of Gibson's romances sans the hockey. The premise is one that's hard to buy in to in a contemporary setting and there's something about the Spanish Basque heritage (hero's family) I was hoping would be a greater part of the story than it ended up being. Good for a quick, light read but ultimately forgettable.
@Lada: If it's forgettable, it's not worth $2.99. Thanks, Lada!
Shanna is probably one of the few Woodiwiss books that be could be read today without too much wincing. I remember it well from my teenage years, but a modern reader may not appreciate it.
hapax
I loved DOLL BONES and it's definitely creepy, but not really about "peer pressure" or "gender normativity". It's about friendship, and the fine line between stories and reality (?), and the bittersweet loss of growing up and "putting away childish things."
I picked up the Holly Black, thanks!
Publishers, in case you ever read this: while I can't speak for anyone else, when I see that the Kindle edition of an upcoming book (in this case, The Coldest Girl in Coldtown) is somehow listed as free, and then I excitedly click over to get it and then find it's only the preview copy of the first eight chapters… it ticks me off. First, it feels like a bait and switch, which makes me less interested in even reading the book's description. Second, in this case, it appears to mean that I can't preorder the Kindle version even if I want to. Grr.
@Kay
It looks like Coldtown is available for preorder, delivery date of 9.3.
The Coldest Girl in Coldtown
@Anne:
Thanks, Anne! It's great to know that it can be ordered. Now I wonder why that 'normal' edition doesn't show up as an alternative (along with hardcover and paperback and two kinds of audio) on the preview page.
@Amy Kathryn:
Thank You for posting about The Lions Lady. I just recently started reading Garwood (shameful I know) and I am very slowly buying her backlist. Can't wait to read this one.
I tried rereading Shanna earlier this year. It was a DNF. Absolute torture to slog through the overwrought syntax and often laughable imagery. Even for $2.99, I'd suggest people read a sample before they buy.
@Kay: You're welcome. That is really odd though! It doesn't show on her author page either. I found it simply by doing a title search on the kindle store. Maybe because it's a preorder? It does show on my ereaderiq page for her but that's probably because they go by name rather than a specific author.
Kaetrin
I haven't read/re-read Shanna in a while but I remember it very fondly. Shanna is a bit of an immature cow for most of the book but Ruark was pretty special and I like the scenes near the end in the US the best I think. I can't decide if it should be in the "guilty pleasure" category or not but it's on my keeper shelf.
I have the Rachel Gibson too. I don't remember a lot about it now but I did enjoy it at the time. I went through a Gibson phase and glommed on all of her backlist at once and that was one of them.
Dabney
I'm a Gibson fan but this one did little for me.
Keishon
August 19, 2013 @ 11:51 pm
I loved Shanna when I read it years ago. Whether I could read it today is another story. Holly Black is great storyteller. I bought that book awhile ago at that price.
RevMelindaPDX
August 20, 2013 @ 1:29 am
I remember liking Shanna back in the day. Can't buy it now tho, because I'm boycotting books where the back-cover text describes the heroine as "tempestuous." It's like fingernails on the blackboard for me.
I read Truly, Madly Yours years ago. I liked the heroine, but really despised the assholic 'hero'. Definitely not Gibson's best, I'd give it a pass.
My secondary school library had a copy of Shanna (who knows how it got there, it had a clinch cover and everything), and I borrowed it multiple times. I didn't particularly like it (even then, I didn't like old-school), but it was romance, and I had no idea where else I could get romance.


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Q: inserting subclasses into a superclasses array in c++ This is one of those things where i just know im doing it wrong. My assignment is simple.
Create 3 classes in c++,
product ,software ,book. product is super, book and software are product.
then make an array of pointers and fill the array with software and books.
so i've done the following
int main()
{
 Product *productList[10];

 Book *pBook;
 Book q(5);
 pBook = &q;
 pBook->getPrice();

 Software *pSoftware;
 Software g(5);
 pSoftware = &g;
 pSoftware ->getPrice();

 productList[0] = pSoftware; // fill it with software, cannot do this.

Is there any way of inserting a subclass into a super classes array. Or should i define the array of pointers as something else.
class definitions below
class Product
{
public:

double price;

double getPrice();

Product::Product(double price){};
};

class Book: public Product
{
public:
Book::Book(double price)
    :Product(price)
{
}
double getPrice();
};

class Software: public Product
{
public:
Software::Software(double price)
    :Product(price)                 // equivalent of super in java?
{
}                                   // code of constructor goes here.
double getPrice();
};

A: You should use public inheritance:
class Book : public Product {
...
};

[edit]
You should also declare getPrice() as virtual if you want to implement it differently in the child classes. This will make compiler call getPrice() of the right child class when you call getPrice() for a pointer to a Product:
virtual double getPrice();

A: As the array is of type Product, you should declare pSoftware as a pointer to Product:
Product *pSoftware = new Software(5);
// ...
productList[0] = pSoftware;

A: It's been a while, but what's the default inheritance type in C++? Should
class Book:Product
{

be
class Book: public Product
{

It's always a good idea to be explicit anyway.

A: Can't you just cast the software* to a product* to put it in your array?
    productList[0] = (Product*)pSoftware;

redpajama_set_name: RedPajamaStackExchange


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text:
Massive surveillance nation: Police now using license plate scanners to collect intelligence on cars, no crime necessary
Saturday, November 10, 2012 by: J. D. Heyes
Tags: surveillance, license plate scanners, police
https://www.naturalnews.com/037914_surveillance_license_plate_scanners_police.html
(NaturalNews) The newest version of the popular video game, "Assassin's Creed," is set in 1775, "a time of unrest in the American colonies." The theme is, of course, the Revolutionary War and it evokes thoughts of the colonists' struggle for freedom and independence from Great Britain.
For me, the game also conjures up thoughts about our country's founding document, the U.S. Constitution and especially the Bill of Rights, which are so badly under assault some 230 years after our founding fathers fought - and died - to enact them.
That is especially true of the Fourth Amendment's right to privacy, and how, little by little, that right to be secure in our "persons, houses, papers, and effects, against unreasonable searches and seizures," is simply vanishing.
Nowhere is this more evident than in the growing surveillance society in which we live, where police are now using tens of thousands of surveillance cameras to monitor Americans everywhere they go, especially when they drive.
Scan an entire mall in a matter of minutes
"License plate scanners are nothing new for law enforcement, but more and more agencies across the U.S. are relying on the technology as equipment becomes more affordable. As the cost of being able to catch a glimpse at every automobile in town drops day by day, though, the odds of being surveilled for simply riding around town is doing just the opposite," RT.com reported.
A recent blog post at PrivacySOS.org lays bare the issue: It directs web surfers to a YouTube video produced by PIPS Technology, a firm that describes itself as a world leader in automated license plate recognition, which is otherwise known as "ALPR" technology.
The technology is installed in police cars around the country. In Little Rock, Ark., for instance, officers say the equipment is well worth the $18,000-per-unit cost.
But while cops are touting its effectiveness, the company itself is silent when it comes to discussing the blatant violations of privacy that occur with each use.
"[It] can scan the mall parking lot in a matter of minutes," Sgt. Brian Dedrick, of the North Little Rock Police Department, tells Arkansas Matters of his ALPR scanner. "We couldn't even do that three years go."
Lt. Christopher Morgon of the Long Beach Police Dept. in southern California agrees that the ALPR technology installed in his agency's cruisers allow officers to do something they could not just a few years ago.
Before adding the technology, he says, officers could only manually dial in about 150 license plates during a shift. But after equipping patrol cars with the ALPR software and adding scores of surveillance cameras, Morgon says that now, the department does much more than just that.
Time to reign in technology
"If you dedicated your day to driving around and putting your vehicle in a place where there's lots of cars, you could read anywhere from 5,000 to 10,000 plates in that same shift," he said, adding that a single patrol car can collect data from upwards of three surveillance cameras simultaneously.
Think about it - 10,000 license plates a day can add megabytes of data to a department's database in a very short period of time. But it is all only used to track down suspects?
In the advertisement, Morgon explains that his department's police cruisers pick up intelligence on every car within sight and logs their location information without ever having to obtain probable cause, which is supposed to be a constitutional requirement - and that's only if someone has been suspected of actually committing a crime.
"Its catching cars that are parked on the side of the road three lanes over. The old technology never would have done that," he says in the advertisement.
Clearly, technology is being used to render our constitutional protections moot. It's way past time for those protections to be reaffirmed by those we elect to serve us.
http://rt.com/usa/news/license-plate-police-department-520/
http://www.youtube.com/watch?v=DKXp5FxVBDA&feature=plcp
http://www.startribune.com/local/minneapolis/177120451.html?refer=y
Surveillance at FETCH.news

redpajama_set_name: RedPajamaCommonCrawl


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TNB reveals "Hayati" second grand prize winner
The National Bank "TNB", announced today the second grand prize (a house and a monthly salary for 20 years) draw result within the first Palestinian women savings program "Hayati," which was awarded to Mr. Mousa Rahal from Bethlehem. Since the program is designed for women, Mr. Rahal granted the prize to his daughter Nadine.
"This was a big surprise for me!" Rahal stated, " I participated in the program a year ago because I believe in the value behind it; I'm a father of 3 daughters who are in college at the same time and education expenses are very high, I saw hope in "Hayati" program which contributes towards empowering women, and ensures them a virtuous life."
Rahal continuous: "I chose Nadine to win the prize because she's special to me, and since she has a special medical condition. I thank God for this prize that will change Nadine's life and I really thank TNB for developing this one of a kind program."
Chief Executive Officer of TNB, Ahmad Hajhasan commented:" Due to the remarkable success of "Hayati" Women Savings Program, it will remain constant. The new promotional campaign will start within weeks with a broadest range of prizes to address achieving financial security and stability for Palestinian women and empowering them economically."
HajHasan also highlighted some of the success stories that accompanied the program whether through the grand prizes that have been granted and changed lives of the winning families, or by financing 86 micro projects with a sum of $1.5 million with zero interest rates to establish entrepreneurial projects run and managed by women, these projects contributed directly towards job creation to hundreds of Palestinian youth. Hajhasan also noted the increase in number of the bank's women clients which serves TNB's goal in achieving a higher percentage of gender financial inclusion.
HajHasan also pointed out that the program will remain on the social responsibility message it carries; donating $1to Dunya Women Cancer Center for every "Hayati" savings account, to support women in combating breast cancer which is considered the number one disease that threatens women's lives around the globe.
The National Bank Le... 2019-07-17
The National Bank Sp... 2019-04-11
The National Bank an... 2019-03-10


Profile description I've left this pretty bare for a while so here goes, i may add to this at a later date. I am 100% single I work and have kids that don't live with me but my kids and work come first always, i will always be discreet and polite and hope to find others the same but unfortunately I have found that difficult on this site due to people showing interest then disappearing into the internet with not even a goodbye half the time, if you're not interested in me, that's fine just say so an I would wish you well and move on but I'm always interested in forging friendships for fun an frolicks and all the other f's that go with it. I can handle a conversation via message or call but generally prefer calls an I'm happy for you to call and withold your number if you wish to call me to verify my identity.
Your interests living life to the fullest.
*urbo76 has been photo-verified and these are genuine photos.


A guided coach tour of Ancient Athens, passing by the Zappeion Garden, Hadrian's Arch, Temple of Olympian Zeus, Anglican Church, St. Nikodimos Byzantine Church, National Garden, Tomb of the unknown Soldier, House of Parliament, Schliemann's House, the Academy, the University, the National Library, the ex Royal Palace (guarded the colorful Evzone), Panathinaiko Stadium, Theatre of Dionysus. Reach the Acropolis and visit the Propylaea Temple of Wingless Victory, Parthenon, Erechteon and the Hill of Philopapos with the breathtaking view of the entire City. The Acropolis Museum is an archaeological museum focused on the findings of the archaeological site of the Acropolis of Athens. The museum was built to house every artifact found on the rock and on its feet, from the Greek Bronze Age to Roman and Byzantine Greece. It also lies on the archaeological site of Makrygianni and the ruins of a part of Roman and early Byzantine Athens. The museum was founded in 2003 while the Organisation of the Museum was established in 2008. It opened to the public on June 21, 2009. Nearly 4,000 objects are exhibited over an area of 14,000 square meters.
Cape Sounion is noted as the site of ruins of an ancient Greek temple of Poseidon, the god of the sea in classical mythology. The remains are perched on the headland, surrounded on three sides by the sea. The site is a popular day-excursion from Athens, with a spectacular view of the Aegean Sea, as viewed from the ruins, a sought-after spectacle. The site is accessible by road from Athens. This is a scenic highway, which closely follows the west coast of Attica (the "Attic Riviera"), passing through numerous upscale residential districts and resorts. From this jutting headland, there is a panoramic view of the surrounding Aegean islands.
The tour to Delphi departs the hotel in the morning for what is considered one of the most important archaeological sites of classical Greece. The ride passes by colourful cliffs en route to the mountain village of Delphi, from which participants have a spectacular view of the olive groves in the valley below as they look out toward the sea. According to mythology, it was here in Delphi that Zeus released two eagles, one from the East and the other from the West.
Following your visit to the excavations, you will have time to visit the Delphi Museum, where all the fine objects on display have been discovered in or near Delphi.


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Home | | Pharmaceutical Biotechnology: Fundamentals and Applications | Gemtuzumab - Monoclonal Antibodies in Cancer
Chapter: Pharmaceutical Biotechnology: Fundamentals and Applications - Monoclonal Antibodies in Cancer
Posted On : 15.06.2017 08:53 pm
Gemtuzumab - Monoclonal Antibodies in Cancer
Pharmacology and Mechanism of Action, Pharmacokinetics/Pharmacodynamics, Indications and Clinical Efficacy, Safety Concerns, Pharmaceutical Considerations: Formulation, Other Routes of Administration, Dosing Regimens.
Gemtuzumab
Pharmacology and Mechanism of Action
Gemtuzumab ozogamicin (GO) was one of the first commercially available bispecific monoclonal antibo-dies. This recombinant, humanized, IgG4 MAb to cell surface marker CD33 is covalently bonded by a bifunctional linker to the potent cytotoxic antibiotic, calicheamicin. Immature and mature myeloid cells, as well as erythroid, megakaryocytic, and multipotent progenitor cells express the 67-kDa glycosylated transmembrane protein CD33. In addi-tion, this protein is expressed on the surface of most leukemic blast cells found in acute myelogenous leukemia (AML) (greater than 90% of patients) as well as myelodysplastic syndromes (MDS) (Van der Velden et al., 2001; Cersosimo, 2003b). However, CD33 is not expressed on stem cells, nor is it expressed outside of the hematopoietic system, making it an excellent therapeutic target. The cytotoxic antibiotic calicheamicin is a natural antineoplastic compound derived from Micromonospora echinospora. It is made up of two molecules of the enediyne antitumor antibiotic n-acetyl-g-calicheamicin dimethyl hydra-zine (Sievers et al., 1999). This compound, along with its metabolites, has antineoplastic activity that is thousand times more potent than doxorubicin (Giles et al., 2003).
GO exerts its clinical effects through direct binding to the CD33 antigen. Following a standard9 mg/m2 infusion, CD33 antigenic sites are maximally saturated within 3 hr (Van der Velden et al., 2001). Endocytosis quickly follows, resulting in rapid inter-nalization of the antibody-antigen complex. Additional expression of new CD33 antigenic sites occurs after internalization of the GO molecule, leading to further accumulation and increased con-centration of intracellular GO (Van der Velden et al., 2001). Once inside the cell, GO is directed to lysosomes which cleave the molecule via acid hydro-lysis, liberating the calicheamicin compound. Calicheamicin then binds to double-stranded DNA helixes in the minor groove, causing site-specific double strand cleavage at oligopyrimidine-oligopur-ine tracts (Zein, 1998; Giles et al., 2003). Induction of apoptosis is observed after approximately 72–96 hr (Van der Velden et al., 2001). In addition to direct induction of apoptosis from calicheamicin, antibody-dependent cell-mediated cytotoxicity and comple-ment-mediated cytotoxicity also stimulate leukemic cell death.
Pharmacokinetics/Pharmacodynamics
Clinical studies investigating the pharmacokinetic parameters of GO have been conducted in adults with AML in first relapse (Dowell et al., 2001; Korth-Bradley, 2001). Initial phase I pharmacokinetic trials found that a dose of 9 mg/m2 fully saturated CD33 sites in all patients regardless of disease burden. Phase II studies confirmed the efficacy of GO in refractory AML patients, and helped consolidate the treatment schedule of two 9 mg/m2 infusions sepa-rated by approximately 14 days. Measurements of serial plasma concentrations have confirmed a distinct difference in pharmacokinetic parameters between the first and second doses, largely thought to be due to a decline in circulating leukemic blast cells that express CD33. A study conducted by Dowell and colleagues in 59 adult patients with relapsed AML found that maximum plasma concentrations (Cmax) of both MAb and calicheamicin typically occurred shortly after the end of the 2 hr infusion; additionally, Cmaxvalues were generally higher after the seconddose (Dowell et al., 2001). Values for Vd changed as well, averaging approximately 20.9 L after the first dose and only 9.9 L after the second (Dowell et al., 2001). This decrease in Vd is likely also due to a decline in the number of circulating cells expressing CD33. In addition, the relatively low distribution volumes suggest that GO does not distribute beyond the plasma compartment, but rather remains bound to CD33 antigenic sites within the vascular space. This has been confirmed by radiolabeled studies, which demonstrates that organs with a large blood pool, such as the spleen and liver, are primarily responsible for uptake and distribution of the antibody(Scheinberg et al., 1991; Caron et al., 1994). Another pharmacokinetic evaluation of GO by Korth-Bradley and colleagues (2001) compared the kinetic para-meters of GO in different populations. Although a great deal of interpatient variability was observed, the authors concluded that there were no significant differences in Cmax, time to Cmax, AUC, clearance, or Vdbetween males and females, nor were there anysignificant differences between those over 60 and those under 60 years of age. Clearance of GO from the plasma occurs mainly through uptake by CD33-positive cells and subsequent internalization, and is therefore influenced by antigen concentration. Elimination half-life of the drug is fairly long, and increases upon second exposure. Median half-life of the antibody component is 72.4 hr after the first dose and 93.7 hr after the second, while the median half-life of the calicheamicin component is 45.1 hr after the first dose and 61.1 hr after the second (Cersosimo, 2003b). Accumulation between doses was not found to be significant, as evidenced by concentrations equivalent to 1% of Cmax measured just prior to the second dose (Dowell et al., 2001b).
Indications and Clinical Efficacy
Results of a phase I study evaluating dose range, pharmacokinetics, and safety of GO in adults with CD33-positive relapsed AML showed that two doses of 9 mg/m2 resulted in > 75% saturation of CD33 antigen on peripheral blood mononuclear cells (Nabhan and Tallman, 2002). Subsequently, a series of three phase II trials utilizing the 9 mg/m2 dose were conducted to evaluate the efficacy of the compound. Initially, 142 patients with untreated, relapsed AML were enrolled. The data were compiled and published in one report (Sievers et al., 2001). The FDA granted approval of GO based on this analysis, but stated that approval was contingent upon ongoing studies to further clarify the role of GO in recurrent AML (Bross et al., 2001; Cersosimo, 2003b). Three years later, a final report summarizing the results of these studies was published by Larson and collea-gues. This study corroborated the findings of the initial data summary (Larson et al., 2005). In total, 277 patients were evaluated. Seventy-one patients (26%) achieved CR, with 35 (13%) fully recovering platelets and 36 (13%) achieving CRp (CR without full platelet recovery > 100,000/L). Median relapse-free survival was 5.2 months for all patients (6.4 months for patients in CR); overall survival was 4.9 months (12.6 months for patients achieving remission). Toxicities consisting of fever, rigors, hypotension, and other infusion-related events were common (grade 3 or 4 infusion reactions occurred in 34% of patients after the first dose, but only 12% after the second dose). Other significant grades 3 and 4 adverseevents were similar to previous reports, and included thrombocytopenia (99%), neutropenia (97%), and infections (25%) (McGavin and Spencer, 2001; Cersosimo, 2003b). The most clinically significant adverse event noted by investigators was hepatotoxi-city, which typically manifested as hyperbilirubine-mia (29% grade 3 or 4) and liver enzyme elevations (18% and 9% for AST and ALT, respectively). These generally appeared within a few days of exposure and were reversible without medical intervention. However, 16 episodes of veno-occlusive disease of the liver (VOD) were reported from 299 administered courses (5%). Other phase II trials have shown similar results (Table 3).
GO has been evaluated in combination with other chemotherapeutic agents (Table 3). Various investigators have explored the utility of GO at different doses and with different agents, including cytarabine, daunorubicin, topotecan, idarubicin, cy-closporine, and fludarabine (Cortes et al., 2002; Estey et al., 2002a,b; Tsimberidou et al., 2003; Piccaluga et al., 2004b). One study utilized the combination of GO with fludarabine, cytarabine, and cyclosporine for treatment of patients with relapsed or refractory AML. The response rate of 30% (CR 28%, CRp 6%) was superior to the typical response rates seen with other regimens in refractory AML (17–20%) (Tsimberidou et al., 2003; Tsimberidou et al., 2005). However, hyperbilirubinemia was reported in 44% of patients, and 9% developed VOD (Bearman, 2000; Tsimberidou et al., 2005). While some combination regimens have shown high response rates, toxicity has remained a significant concern. The exact role of GO in combination with other chemotherapeutic agents requires further investigation.
Significant activity has been demonstrated with the use of GO in the treatment of acute promyelocytic leukemia (APL) (Estey et al., 2002a; Lo-Coco et al., 2004). Cells isolated from APL patients frequently express CD33, and are therefore an effective target for GO (Tsimberidou et al., 2005). A study by Lo-Coco and colleagues (2004) evaluated GO as single-agent therapy in patients with advanced stages of APL, and found that after two doses were administered, 91% patients attained a molecular remission (MR); after three doses were administered, essentially 100% of 13 patients achieved MR. Only 1 patient (6%) developed clinically significant hepatotoxicity (grade 3), and this patient had received stem cell transplanta-tion and had chronic GvHD during therapy (Lo-Coco et al., 2004). Combination therapy for APL has also been studied; Estey and colleagues (2002a) adminis-tered GO with tretinoin in newly diagnosed APL patients, and found a response rate of 84%. Therapy was relatively well tolerated, and no patients devel-oped VOD. The authors concluded that GO appears to demonstrate activity in and be feasible for the treatment of APL.
GO is associated with a variety of adverse effects, the most common of which are infusion-related reactions, hepatotoxicity, and myelosuppression (Giles et al., 2003). Myelosuppression is profound and prolonged, occurring in 99–100% of patients; counts typically nadir at 7–14 days and recover within 28–35 days (Giles et al., 2003). In some cases, recovery may take even longer, and platelets may never return to normal values. Infusion-related events, including fever, rigors, hypotension, dyspnea, nausea, emesis, and headache are common as well; however, these are typically mild in severity, and risk decreases after initial exposure (Larson et al., 2005; Tsimberidou et al., 2005). Premedication with corticosteroids and diphenhydra-mine may reduce this complication. Hepatotoxicity associated with GO therapy is another recognized adverse effect. Hyperbilirubinemia and transaminase elevations are often mild and reversible without medication, occurring within 8 days of drug exposure and lasting approximately 20 days (Giles et al., 2003). However, a more concerning manifestation of hepato-toxicity is VOD. This seems to be more common when GO is used in combination with other chemotherapeu-tic agents, or after SCT (Giles et al., 2003). When GO is utilized in the approved single-agent manner, VOD incidence is approximately 1–5%. However, when GO is used in combination therapy, VOD risk increases to 5–12%. Age, gender, underlying disease, preexisting renal or hepatic function, alcoholism and hepatitis history do not predict which patients will develop VOD (Giles et al., 2003). It has been postulated that premedication with acetaminophen could increase the risk of VOD; interference with glutathione oxida-tion-reduction reactions by acetaminophen could leave sinusoidal endothelial cells susceptible to attack by calicheamicin-generated free radicals, thus increasing the risk of toxicity. Until the exact mechanism of VOD is elucidated, some clinicians advocate the avoidance of premedication with acetaminophen prior to GO treat-ment (Gordon, 2001; Cersosimo, 2003b). VOD remains a significant concern with GO therapy, and more data are needed to determine the risks and benefits of treatment with this agent.
Pharmaceutical Considerations: Formulation, Other Routes of Administration, Dosing Regimens
GO is indicated for the treatment of CD33-positive AML in first relapse for patients ‡ 60 years of age who are not candidates for other chemotherapy. The recommended dose is 9 mg/m2 IV over 2 hr repeated after 14 days for a total of two doses (Wyeth, 2006).
GO is commercially formulated as a lyophilized powder for injection in 5 mg amber vials. The contents of each vial should be stored under refrigeration (2LC to 8LC) and protected from light. After reconstitution with 5 mL sterile water for injection, the appropriate amount of drug should be drawn up and further diluted with 100 mL of sterile 0.9% sodium chloride for injection. This product should be protected from light with the addition of a UV-protectant bag. Infusions should be administered over 2 hr through an intravenous line that is equipped with a low-protein-binding 1.2 mm terminal filter. This medication can be infused peripherally or centrally. Patients should also receive appropriate premedica-tion with diphenhydramine prior to receiving GO (Wyeth, 2006).
PK/PD in Clinical Development of Antibody Therapeutics
Mechanistic Modeling Approaches - Translational Medicine/Development Process
Population PK of Monoclonal Antibodies
Monoclonal Antibodies in Cancer
Alemtuzumab - Classes of Monoclonal Antibodies: CD Antigens
Rituximab, Yttrium-90 (90Y) Ibritumomab Tiuxetan, Iodine-131 (131I) Tositumomab
Bevacizumab - Classes of Monoclonal Antibodies: Vascular Endothelial Growth Factor Inhibitors
Trastuzumab - Classes of Monoclonal Antibodies: Endothelial Growth Factor Receptor (EGFR) Inhibitors
Cetuximab - Classes of Monoclonal Antibodies: Endothelial Growth Factor Receptor (EGFR) Inhibitors
Panitumumab - Classes of Monoclonal Antibodies: Endothelial Growth Factor Receptor (EGFR) Inhibitors
Monoclonal Antibodies in Solid Organ Transplantation
Immunologic Targets: Rational Development/ Use of Monoclonal Antibodies in Organ Transplant


In an article by Luke Carmen in Meanjin (Autumn 2016) he observes "the senselessness, doubt and despair our anti-art overlords are inculcating in our so-called culture industries". "Getting Square in a Jerking Circle", overwritten and jejune as it is, assails the arts philistines who will always be with us, and is certainly about the mark as far as that goes. But so what? Take the cash, and the art will look after itself.
The work is the thing. We do what we can to put some bread and cheese and if we're lucky, jam, on the table. But that is fuel, to fuel our inspiration. Unless you actually dream of "being invited down to the wharf to break canapes with all those cynical shysters with champagne flutes glowing in their eyes, and business cards clutched in their hands" (as Carmen puts it neatly but almost wistfully), rise above it, and get back to work.


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Meet the Accessibility Roundtable: Anne Prusky
Meet the Accessibility Roundtable: In this series, we'll be getting to know the team members that make up this cross-departmental working group to improve OneTable's accessibility (learn more about the Accessibility Roundtable here). Join Naomi (they/them), Miami Field Manager, and Anne Prusky (she/her), Manager of Development & Research, in a conversation about Anne's story, why she joined the roundtable, and what she loves about this work.
How did you get involved in accessibility work?
In college, I made friends who were disabled or chronically ill for the first time. I started taking American Sign Language and Deaf Studies, and learning from the local Deaf community became central to my undergraduate education. I ended up designing my own major in college in order to incorporate all that I was learning about the way language impacts society and society impacts language.
I learned that part of being a responsible signer was being an advocate and ally to the Deaf community, which often meant shutting up (literally – AKA not using my voice – but more importantly, not positioning myself as an expert, and instead elevating words and thoughts of Deaf community members when it comes to issues that affect their community). I had never thought about the fact that I could hear as a privilege. This responsibility made me realize that I needed to uplift and advocate, and then step aside to make room for other folks to have their stories, experiences, and advocacy centered.
I also learned about the concept of Deaf Gain – the idea of Deafness as a positive, affirmative identity, rather than centering a "lack" or "loss" of hearing. This encouraged me to reframe my understanding of ability and disability and to shift to a cultural/social model that puts the onus on society to change and adapt, rather than putting pressure on the individual to conform.
What does accessibility mean to you?
When it comes to OneTable, I think we use the term accessibility in two ways that are often overlapping:
Come as you are! You don't have to be an expert to engage in this experience. For example, anyone at any level of Jewish fluency can arrive and plug into an offering of ours.
Ability vs. disability: Thinking about inclusion, we want to ensure that the reality of people's bodies and minds aren't preventing them from engaging with Shabbat. And, further, we want to move into a realm of belonging — in that people's full selves are contributing to and even improving an experience.
Normally, we think about these as two different pursuits, but at OneTable's Accessibility Roundtable, we are thinking about these two concepts as pillars of the same mission.
There are all sorts of reasons one might experience a barrier to engaging with OneTable and Shabbat, and our team is working on creating a community in which everyone can show up as their full selves.
How does improving accessibility benefit the OneTable community?
Our OneTable community is stronger when we have a lot of different voices at the table. More diversity in a community brings new ideas and new inspiration. For example, if we're creating a program and need to shift some aspect of it to accommodate one person — this can actually open a whole new world and allow creativity and ingenuity for everyone involved. In working to include one person or one group, we end up designing a system or program that is better for everybody.
This is known as the Curb Cut Effect. The "Curb Cut Effect" is the idea that an accommodation or adjustment for one person can end up benefiting other people that weren't initially intended. Curb cuts were designed for people with wheelchairs, but they also help little kids get up on the sidewalk, make it easier to wheel groceries to your car…thanks to the activism of folks in wheelchairs, our streets are now more accessible for everybody.
What is a program or initiative you've been involved with at OneTable to improve accessibility?
I started at OneTable as the DMV Field Manager and one of my first programs was a Deaf Shabbat. It was co-organized with Tori Greene, who was the Miami Field Manager at the time, and Jacob Salem, Director of Hillel at Gallaudet. It was essentially a community Shabbat dinner that was ASL First. Usually, hearing and spoken language is centered and it was really awesome to create a space in which sign language, and the Deaf experience, was at the fore. I felt so lucky to be a part of that experience and to meet new friends through Shabbat!
The experience of bringing that to OneTable, and especially having my colleagues be so enthusiastic about it, inspired me to help found the Accessibility Roundtable, so that initiatives like this could move from being one-off to being integrated in how we develop programming.
What's something you're excited to learn more about?
I've been very grateful to learn somewhat about physical disabilities, but I know very little about intellectual disabilities. I used to think that this meant that I couldn't be involved, but being on the Accessibility Roundtable has allowed me to learn about areas that I didn't know so much about. I want to meet more people with intellectual disabilities, build community, and celebrate Shabbat together!
In what ways does the work of your specific department need to be mindful of accessibility needs?
In regards to the research part of my work, I collect stories and experiences from our users and find ways to share those discoveries based on their sharings. It's important that that information is accessible to the people who shared those stories, particularly for an organization where research is so central, like OneTable. I feel a responsibility to make sure we share our findings back out in the world, in a way that many different folks can find meaningful. For example, that means thinking about people who haven't taken a statistics class, and also ensuring that our charts are color coding-accessible. Sometimes screen readers have a hard time reading charts. It's important to ensure that the info is also in a paragraph, so that if the visual doesn't work for you, then you also have a verbal explanation. And vice versa.
When I think about my development work, I'm thinking about ways for our whole community — hosts and guests, donors, staff, partners, even those who went to a dinner ages ago and haven't been back, but still think of Shabbat fondly — to be a part of shaping OneTable now and into the future. One of the things I love most about OneTable is that rather than guessing or prescribing what our community should do, we get a lot of feedback from our whole network, and we act on that feedback to serve our community better. I want us to keep making decisions in response to the diverse needs of our participants and shifting our programming to meet the needs that emerge. The elevation of this broad spectrum of thoughts is what stands out to me about OneTable's pursuit of accessibility.
OneTable
Accessibility . Meet the Team
accessibility, shabbat
OneTable empowers people who don't yet have a consistent Shabbat dinner practice to build one that feels authentic, sustainable, and valuable. The OneTable community is funded to support people (21-39ish), not in undergraduate studies, and without an existing weekly Shabbat practice, looking to find and share this powerful experience.
Meet the Accessibility Roundtable: Emily Zussman
Meet the Accessibility Roundtable: Chris Phillips


Vehicle manufacturers have shown an increasing wil-lingness to use aluminum in a wider variety of components, helping create an overall growth market for the light metal.
While aluminum producers appreciate the ongoing appetite, the sector's growth also has attracted investors from around the world. The end result for many secondary aluminum furnace operators is an overabundance of competition, even in a growth sector.
The list and map of North American secondary aluminum producers include facilities in a range of sizes operated by companies as large as Alcoa or as small as a one-location family-owned scrap yard.
The list was last published in mid-2015. In the ensuing two-and-a-half years, the changes have not been enormous, but disruption could be on the way in form of a Chapter 11 bankruptcy filing by the company with the most facilities on the list.
Court officials, attorneys, creditors and executives are in the midst of formulating a Chapter 11 reorganization plan for Real Alloy. The Cleveland-based firm was operating 15 scrap-fed aluminum melt shops in 14 cities (13 in the United States, one in Canada) at the time of its bankruptcy filing in November 2017.
Some of these plants have operated for decades under several different ownership groups. No certainty is attached to what a reorganization plan will include, but it seems doubtful that every Real Alloy plant will remain in operation when the company emerges from bankruptcy.
A name change on this year's list involves the former Sapa Extrusions. In 2017, Norway-based Hydro—which had been a co-owner of Sapa along with the Norway-based Orkla Group—bought out its partner. Hydro now refers to those assets as its Extruded Solutions business area.
Another Scandinavian company, Sweden-based Gränges, has entered the North American market by purchasing two aluminum plants operated by the former Noranda.
Braidy Industries is building a new facility in eastern Kentucky that is scheduled to come online in 2020. Kentucky's state government offered considerable incentives to attract the $1.3 billion, 370,000-ton-per-year facility, which reportedly included taking a 20 percent ownership stake in the plant.
A "thank you" is owed to Recycling Today readers who helped identify and verify the 100-plus facilities on our list. Changes to the secondary aluminum sector are certain to continue in 2018 and beyond. As well, doubtless other facilities that we did not uncover belong on this list. If you know of one, please contact me by email at btaylor@gie.net with that information.


Jake Winkman is a part-time agent with the CIA.
He prefers to think of himself in his other profession, that of professional card player. The exploits of Jake Winkman is one of those razor-edge borderline cases of what is or is not a spy series. Winkman is most definitely not a spy. He is a bridge pro. Still, he does help out the CIA in his spare time and those adventures form the mold around which his activities take place.
But even more than spy cases, the overwhelming purpose of the books is teaching the reader how to be a bridge pro. This is someone who makes a living teaching people to play bridge and, more importantly, attending bridge tournaments with them as their partner to amass points towards being a Master or better at that addictive card game.
For the uninitiated, a person becomes a Bridge Master by attending and doing well at authorized tournaments around the world. Since this form of bridge is a partnership style, when the partnership does well, both members earn the points. Therefore, having a good teacher is important to doing well and having a good partner is even more so. Winkman makes a very nice living travelling, expense-paid, of course, to various exotic locales, and many not so exotic, and on cruises where wealthy people eager to make bridge points make frequent use of him.
And since Winkman is going to these places and is expected to go there and is very much a known quantity and thus able to blend in well, he is a perfect man to be asked by the Agency to do little things for them.
While the author, through the Winkman character, sets the scene for many events at the various tournaments and shows the hands he and his partners have there, he also explains the rationale behind the bids and the plays.
The tournament is in Honolulu and along with the hot weather and hotter card play, there are corpses lying around and spies in the closets.
What the FBI doesn't disturb in the tournament in the nation's capital, the CIA more than covers. Jake Winkman deals with trump, dead bodies, and beautiful women.
While a master of disguise does all he can to steal the country's newest weapon, Jake Winkman just wants to get through the L.A. tournament with his pride intact.
A compendium of 3 novelettes and 6 short stories depicting Jake Winkman adventures, only a couple of which seem spy related.
There is nothing of an espionage nature in this book that deals with a long bridge cruise but there is one heckuva good travelogue about the Far East.
Three novelettes, three short stories, and three 'system' short stories make up this compendium of tales of Jake Winkman's bridge life.
If you are an avid bridge fan, you'll likely enjoy these stories, though the amount of bridge information thrown at you is intense. I am a fan and I did enjoy them but I was overwhelmed. If you are not a bridge fan, you will not want to even start. Espionage, action, anything non-bridge is tertiary (forget secondary) to the play of the cards.
These books are intended as a training tool and the series is a lot of fun to read, if you are a bridge fanatic, which I have been for years. If you are not, this book will drag slower than a VW bug with three flat tires.


The healthier we become in body, heart, mind & spirit, the healthier our world becomes on social, political, economic & environmental levels.
c) Our Universal Health - Earth as a healthy planet & our place in the interdimensional worlds.
EXPERIENCING HEALTH ENHANCEMENT:- The first step into enhanced personal health can be as simple as applying and experiencing the benefits of our Luscious Lifestyles Program and the changes this lifestyles brings on both the Personal & Global Health Paradigms. In the Youtube Video on The Embassy of Peace - Luscious Lifestyles Program Jasmuheen elaborates on the 8 point Luscious Lifestyles Program for personal harmonization - as offered by the Embassy of Peace for the enhancement of individual and global health.
Meditation - link to series of videos on benefits of meditation & also brief meditations to practice the art.
Prayer - link to video.
Programming - link to video. Part 1; part 2.
Vegetarian Diet - link to video. Amusing vegetarian quotes video.
Jasmuheen on the Luscious Lifestyles Program & Human Evolution interview with Supreme Mastery TV.
As we have mentioned, one step at the Embassy of Peace to fulfill our projects, has been to understand by living it, the dynamics of conscious energy field fine-tunement. Many in our world have now found that good thinking, good dreaming and pure-hearted living can reveal other doors that beckon us to enter and walk a rhythm that I can only describe as "being love in action".
Personally I feel so blessed in this now moment that all I can do is sing as I fly along these cosmic air waves in a state that feels like the fluid rhythm of love in action. It is a marvel to behold what is flowing through me and all around me now for there is a grace within these subtle realms that one can only behold and then stand in awe of, for it brings an order and a flow, a current of energy that is so pleasing harmonically to my deepest, purest being.
This frequency arises within us all when it is our deepest heart's desire to be nourished by what it brings ... and to be united in the sweetest most succulent rhythm of mutual energy field enhancement.
Many also know that it is a time now to honor our intelligence, to embrace and tune in deeper to that which touches our soul and to let the voice of heaven call our name as it floods us with its essence, as we allow our personal dreaming to be our beacon home.
We know also that it is a time to do what unites us further and to let harmony be our guide and that it is a time to let go of everything else, every other worry. No chaos can touch the essence of the purest you within, for its light will guide us as each one of us now chooses to enhance the other.
Each one of us is king and queen so let us rise in this moment in the glory of that which we are, united in a greater truth and live in harmony's field, let us blend in brotherhood and sisterhood united in our field of peace for we are the field keepers, the dream-weavers, those who sing and play. We are the poets of life and we know now that we can all exist in the grandest state.
Many now have felt the call to be quiet and still, to go deeper within, to meditate on the highest dreaming and to make our personal existence as harmonious as possible within the fields of life. Applying the steps provided here can only add to it all."
Programs & Projects - Embassy of Peace:- Personal, Global & Universal Harmonization Programs & Projects for the co-creation of unity and permanent peace on Earth. This manual combines the Luscious Lifestyles Program with its 8 point lifestyle plan, with the Madonna Frequency Planetary Peace Program, and adds the Embassy's Universal Harmonization Program offering finetuning methods for our Ambassadors of Peace.
Designed to promote individual and global health and happiness, these programs also promote permanent peace and prepare Earth en-mass to enter into higher paradigms.
Covering lifestyle practices, world health and hunger issues plus extra-terrestrial realities, and more, this manual also helps in the training of the Embassy's Ambassadors of Peace and Diplomats of Love. With over 150,000 copies of the Embassy's Programs downloaded freely a year, in various languages, we now offer this complete 200 page manual FREE as a download from our website OR via our lulu.com homepage in paperback for those who require it in book form.
Click HERE to preview and order your copy. Print: US$24.50 + postage.


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Written by John McHale
The COTS Confidential Roundtable gathers experts from the defense electronics industry – from major prime contractors to defense component suppliers. Each Roundtable will explore topics important to the military embedded electronics market. This issue, we discuss how embedded computing suppliers are leveraging artificial intelligence (AI) for military applications, the impact of the Sensor Open Systems Architecture (SOSA) Consortium and other open architecture initiatives, and the outlook for the future of embedded technologies in the defense and aerospace markets with sponsors of the Embedded Tech Trends (ETT) conference, held during late January in Atlanta, Georgia.
This time, our panelists are Rodger Hosking, Vice President and Co-founder, Pentek; David Jedynak, Chief Technology Officer, Curtiss-Wright Defense Solutions; John Bratton, Director of Product Marketing, Mercury Systems; and Doug Patterson, Vice President, Global Marketing, Aitech Systems.
MIL-EMBEDDED: Artificial intelligence, or AI, was the topic of many presentations at ETT this year. How is AI making an impact in military electronics? Which applications are benefitting from the technology now? Electronic warfare? Radar? Other?
HOSKING: Virtually all military electronics are benefiting from AI, and the technology is moving quickly. The first applications are "expert systems" that deliver relatively quick decisions and actions for a relatively narrow task. These include classification and identification of all objects in the operating theater of war, and even determining the most effective countermeasures or attack strategies. Another very important application is extracting critical intelligence from the glut of electromagnetic spectrum signals and internet traffic of all types, and then detecting patterns or relationships among those signals for further action. With continued expansion of deployed unmanned military vehicles, autonomous AI systems can help boost their survival rate and mission effectiveness. AI is not just developing smart engines, neural networks, or algorithms. It requires engineering of hundreds of specialized systems, each evolving over time to exploit a broader scope of sensor inputs, and more complex decision-making elements and principles to deliver increasingly accurate, targeted results.
JEDYNAK: Machine learning, deep learning, and AI are revolutionizing applications that help warfighters identify threats and objects from afar, detect unseen dangers, and locate and resolve equipment issues before failures occur. AI is key to the DoD's Third Offset Strategy [which seeks to outmaneuver advantages made by top adversaries primarily through technology]. The specific examples almost don't matter – we can take it as a given that it provides a significant leap forward. Think of the automobile versus horse and buggy: While so much remains extremely familiar, and on a spec sheet may not look all that different (i.e., four wheels, room for passengers, leather seats, room for luggage, luxury styling, etc.), the performance/capability difference is immense. In electronic warfare (EW), for example, AI enables machines to identify objects and take appropriate actions in a faster and more accurate way than humans can on their own. In signals intelligence (SIGINT) applications, machine learning and deep learning can be used to automate signal classification, which otherwise typically requires extensive expertise and is prone to human error.
Another key area where machine learning capabilities can be applied to increase the safety of warfighters and equipment is health and usage monitoring systems (HUMS). It enables computers to be trained to intelligently predict when equipment failures are most likely to occur and allows issues to be addressed before a mission is affected. For example, if a HUMS application detects that extra power is being applied to a wheel on a Humvee, it could mean the pressure in that tire has dropped and the tire could collapse. The same technology can also be used to inspect the physical integrity of air and ground vehicles before and after field operations. Ultimately, AI is enabling faster, more accurate identification of threats to today's military platforms and helping deliver a competitive edge by accelerating and strengthening functions traditionally performed by humans.
SOSA and Open Standards for Military Embedded Computing
Embedded computing systems in forward-deployed vehicles that meet SOSA certification will enable easier replacement of components and even upgrades thanks to vendor-agnostic requirements.
EW and the DoD's MOSA Mandate
Electronic Warfare (EW) system designers must constantly respond to new threats and come up with appropriate ways to respond.
Multi-INT and SOSA: A Consideration of Next Steps
One of the key tenets of Multi-INT or multi-modality is that the architecture by its very nature is realizable through the core components of a sensing system which can accommodate more than one mission at the same time.
David Jedynak
Business Unit Director and Technical Fellow
David Jedynak is Business Unit Director for Curtiss-Wright's Salt Lake City facility, home of the Parvus small form factor network and computing products. David is also a Curtiss-Wright Technical Fellow. Previously, he served as Chief Technology Officer for Curtiss-Wright Defense Solutions for many years, and continues to provide technology leadership for the group. David joined Curtiss-Wright in 2008, and has focused his expertise in network-centric systems, COTS solutions and Assured Position, Navigation and Timing. He actively drives and supports the adoption of modular open standard approach (MOSA) architectures for the defense industry to accelerate technology deployment. Prior to joining Curtiss-Wright, David worked in both the automotive electronics and film industries on the forefront of industry-wide migrations to cutting-edge open standard digital architectures. He holds a BS Electrical Engineering from UCLA, as well as a Certificate in Astronautical Engineering and a Certificate in Project Management, both also from UCLA.
Open standards are key to resolving today's challenges
As a result of our long-time commitment to developing modular COTS solutions based on open standards architecture, along with our dedication to industry collaboration and open standards development, Curtiss-Wright is ideally positioned to deliver ruggedized, reliable, and secure COTS solutions that are aligned with key industry standards.
Machine Learning and Artificial Intelligence in Defense and Aerospace Applications
This white paper discusses the terminology, applications, challenges and technology enablers for machine learning, deep learning and artificial intelligence (AI) in the aerospace and defense markets.
The Open Group Sensor Open Systems Architecture (SOSA) and CMOSS Brochure
Curtiss-Wright to Showcase MOSA-based Tactical Warfighter Communications and Processing Solutions at Modern Day Marine 2022
Curtiss-Wright Showcases New Rugged MOSA-based Solutions for Ground Vehicles and Live System Solution Demonstrations at AUSA 2022
Curtiss-Wright to Showcase MOSA Solutions at Tri-Service Open Architecture Interoperability Demonstration TIM & Expo
Simplifying the Integration of Assured PNT with CMOSS/SOSA-Aligned Solutions
Electronic Warfare as Easy as Changing a Light Bulb
SOSA Technical Standard Will Benefit Systems of all Kinds
SOSA Open-Systems Standard for Embedded Computing, Sensor Processing Could be in Final Form by This Summer
Sensor Open Systems Architecture (SOSA): Enabling the Next Generation of Flexible and Adaptable Radar Systems
SOSA Briefing Outlines Future Defense Sensor System Architectures
Open Standards Need Open Minds
Open Architecture Initiatives Bolster Unmanned Sensors and Systems
The Latest Trends in Rugged Computing
The Coming Revolution in Sensor and Signal Processing
Army TITAN Team from Raytheon Leverages MOSA Expertise
The Ever-Shrinking World of Small-Form-Factor Embedded Computing
Accelerate Open Standard Adoption to Drive Warfighter and Weapon-system Effectiveness
Curtiss-Wright Establishes MOSA Task Force to Drive Developed in Alignment with CMOSS & SOSA Technical Standards
When High-Performance Embedded Computing Meets Open-Systems Standards
Why an Open Standards Approach Is Essential in Defense and Aerospace
Modular Open Systems Approach (MOSA): Why Open Standards Like CMOSS and SOSA Are the New Normal
Choosing the Best Processor for the Job
How Can I Teach My Machine to Learn


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Home MIL NZ OSI Bachelor of Business Studies
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text:
Conero
This Application collects some Personal Data from its Users.
Hotel Ristorante Mira Conero di Leonardi Sauro,
info@miraconero.it
www.miraconero.it
Among the types of Personal Data that this Application collects, by itself or through third parties, there are: email address, Cookies, Usage Data, first name, last name, phone number, company name, country, ZIP/Postal code, city and various types of Data.
Personal Data may be freely provided by the User, or, in case of Usage Data, collected automatically when using this Application.
Unless specified otherwise, all Data requested by this Application is mandatory and failure to provide this Data may make it impossible for this Application to provide its services. In cases where this Application specifically states that some Data is not mandatory, Users are free not to communicate this Data without consequences to the availability or the functioning of the Service.
Any use of Cookies – or of other tracking tools – by this Application or by the owners of third-party services used by this Application serves the purpose of providing the Service required by the User, in addition to any other purposes described in the present document and in the Cookie Policy, if available.
Users are responsible for any third-party Personal Data obtained, published or shared through this Application and confirm that they have the third party's consent to provide the Data to the Owner.
The Data processing is carried out using computers and/or IT enabled tools, following organizational procedures and modes strictly related to the purposes indicated. In addition to the Owner, in some cases, the Data may be accessible to certain types of persons in charge, involved with the operation of this Application (administration, sales, marketing, legal, system administration) or external parties (such as third-party technical service providers, mail carriers, hosting providers, IT companies, communications agencies) appointed, if necessary, as Data Processors by the Owner. The updated list of these parties may be requested from the Owner at any time.
The Data is processed at the Owner's operating offices and in any other places where the parties involved in the processing are located.
Depending on the User's location, data transfers may involve transferring the User's Data to a country other than their own. To find out more about the place of processing of such transferred Data, Users can check the section containing details about the processing of Personal Data.
The Data concerning the User is collected to allow the Owner to provide its Services, as well as for the following purposes: Managing contacts and sending messages, Analytics, Contacting the User, Interaction with external social networks and platforms, Content commenting, Remarketing and behavioral targeting, SPAM protection, Displaying content from external platforms, Infrastructure monitoring, Backup saving and management, Advertising, Content performance and features testing (A/B testing), Registration and authentication, Interaction with online survey platforms, Handling payments, Managing landing and invitation pages, Interaction with data collection platforms and other third parties, Platform services and hosting and Data transfer outside the EU.
Users can find further detailed information about such purposes of processing and about the specific Personal Data used for each purpose in the respective sections of this document.
This type of services allows User Data to be utilized for advertising communication purposes displayed in the form of banners and other advertisements on this Application, possibly based on User interests.
Some of the services listed below may use Cookies to identify Users or they may use the behavioral retargeting technique, i.e. displaying ads tailored to the User's interests and behavior, including those detected outside this Application. For more information, please check the privacy policies of the relevant services.
Direct Email Marketing (DEM) (This Application)
This Application uses the User Data to propose services and products provided by third parties or unrelated to the product or service provided by this Application.
Personal Data collected: email address.
Backup saving and management
This type of services allows the Owner to save and manage backups of this Application on external servers managed by the service provider itself. The backups may include the source code and content as well as the data that the User provides to this Application.
Backup on Dropbox (Dropbox, Inc.)
Dropbox is a service to save and manage backups provided by Dropbox Inc.
Personal Data collected: various types of Data as specified in the privacy policy of the service.
Place of processing: US – Privacy Policy.
Backup on Google Drive (Google Inc.)
Google Drive is a service to save and manage backups provided by Google Inc.
Content commenting
Content commenting services allow Users to make and publish their comments on the contents of this Application.
Depending on the settings chosen by the Owner, Users may also leave anonymous comments. If there is an email address among the Personal Data provided by the User, it may be used to send notifications of comments on the same content. Users are responsible for the content of their own comments.
If a content commenting service provided by third parties is installed, it may still collect web traffic data for the pages where the comment service is installed, even when Users do not use the content commenting service.
Facebook Comments (Facebook, Inc.)
Facebook Comments is a content commenting service provided by Facebook, Inc. enabling the User to leave comments and share them on the Facebook platform.
Personal Data collected: Cookies and Usage Data.
Data transfer outside the EU
The Owner is allowed to transfer Personal Data collected within the EU to third countries (i.e. any country not part of the EU) only pursuant to a specific legal basis. Any such Data transfer is based on one of the legal bases described below.
Users can inquire with the Owner to learn which legal basis applies to which specific service.
Data transfer from the EU and/or Switzerland to the U.S based on Privacy Shield (this Application)
If this is the legal basis, the transfer of Personal Data from the EU or Switzerland to the US is carried out according to the EU – U.S. and Swiss – U.S. Privacy Shield.
In particular, Personal Data is transferred to services that self-certify under the Privacy Shield framework and therefore guarantee an adequate level of protection of such transferred Data. All services are listed within the relevant section of this document and those that adhere to Privacy Shield can be singled out by checking their privacy policy and possibly also by specifically checking for Privacy Shield adherence in the official Privacy Shield List. Privacy Shield also specifically guarantees rights to Users which can be found in its most current form on the website run by the US Department of Commerce.
Personal Data may be transferred from within the EU or Switzerland to the U.S. to services that are not, or not anymore, part of Privacy Shield, only based on other valid legal grounds. Users can ask the Owner to learn about such legal grounds.
Personal Data collected: various types of Data.
Handling payments
Payment processing services enable this Application to process payments by credit card, bank transfer or other means. To ensure greater security, this Application shares only the information necessary to execute the transaction with the financial intermediaries handling the transaction.
Some of these services may also enable the sending of timed messages to the User, such as emails containing invoices or notifications concerning the payment.
PayPal (PayPal Inc.)
PayPal is a payment service provided by PayPal Inc., which allows Users to make online payments.
Place of processing: See the PayPal privacy policy –Privacy Policy.
Interaction with data collection platforms and other third parties
This type of service allows Users to interact with data collection platforms or other services directly from the pages of this Application for the purpose of saving and reusing data.
If one of these services is installed, it may collect browsing and Usage Data in the pages where it is installed, even if the Users do not actively use the service.
MailChimp widget (The Rocket Science Group, LLC.)
The MailChimp widget is a service for interacting with the MailChimp email address management and message sending service provided by The Rocket Science Group LLC.
Personal Data collected: email address, first name, last name and phone number.
Place of processing: United States – Privacy Policy. Privacy Shield participant.
Interaction with online survey platforms
This type of service allows Users to interact with third party online survey platforms directly from the pages of this Application.
SurveyMonkey Widget (SurveyMonkey Inc.)
The SurveyMonkey Widget is a service for interacting with the SurveyMonkey online survey platform provided by SurveyMonkey Inc.
Managing landing and invitation pages
This type of service helps with building and managing landing and invitation pages, i.e., pages for presenting a product or service, where you may add your contact information such as an email address.
Managing these pages means that these services will handle the Personal Data collected through the pages, including Usage Data.
Mailchimp Landing Page (The Rocket Science Group, LLC.)
Mailchimp Landing Page is a landing page management service provided by The Rocket Science Group, LLC., that allows this Application to collect the email addresses of Users interested in its service.
Mailchimp Landing Page allows the Owner to track and analyze the User response concerning web traffic or behavior regarding changes to the structure, text or any other component of the created landing pages.
Registration and authentication
By registering or authenticating, Users allow this Application to identify them and give them access to dedicated services.
Depending on what is described below, third parties may provide registration and authentication services. In this case, this Application will be able to access some Data, stored by these third party services, for registration or identification purposes.
Direct registration (This Application)
The User registers by filling out the registration form and providing the Personal Data directly to this Application.
Personal Data collected: city, country, email address, first name, last name, phone number and ZIP/Postal code.
WordPress.com Single Sign On (Automattic Inc.)
WordPress.com Single Sign On is a registration and authentication service provided by Automattic Inc. and is connected to the WordPress.com network.
Log In with PayPal (PayPal Inc.)
Log In with PayPal is a registration and authentication service provided by PayPal Inc. and is connected to the PayPal network.
This type of services analyzes the traffic of this Application, potentially containing Users' Personal Data, with the purpose of filtering it from parts of traffic, messages and content that are recognized as SPAM.
Akismet is a SPAM protection service provided by Automattic Inc.
Google reCAPTCHA is a SPAM protection service provided by Google Inc.
The use of reCAPTCHA is subject to the Google privacy policy and terms of use.
Google Analytics is a web analysis service provided by Google Inc. ("Google"). Google utilizes the Data collected to track and examine the use of this Application, to prepare reports on its activities and share them with other Google services.
Place of processing: US – Privacy Policy – Opt Out.
Google Analytics with anonymized IP (Google Inc.)
This integration of Google Analytics anonymizes your IP address. It works by shortening Users' IP addresses within member states of the European Union or in other contracting states to the Agreement on the European Economic Area. Only in exceptional cases will the complete IP address be sent to a Google server and shortened within the US.
Facebook Ads conversion tracking (Facebook, Inc.)
Facebook Ads conversion tracking is an analytics service provided by Facebook, Inc. that connects data from the Facebook advertising network with actions performed on this Application.
Google AdWords conversion tracking (Google Inc.)
Google AdWords conversion tracking is an analytics service provided by Google Inc. that connects data from the Google AdWords advertising network with actions performed on this Application.
Analytics collected directly (This Application)
This Application uses an internal analytics system that does not involve third parties.
WordPress Stats (Automattic Inc.)
WordPress Stats is an analytics service provided by Automattic Inc.
Contacting the User
By registering on the mailing list or for the newsletter, the User's email address will be added to the contact list of those who may receive email messages containing information of commercial or promotional nature concerning this Application. Your email address might also be added to this list as a result of signing up to this Application or after making a purchase.
Contact form (This Application)
By filling in the contact form with their Data, the User authorizes this Application to use these details to reply to requests for information, quotes or any other kind of request as indicated by the form's header.
Personal Data collected: company name, email address, first name, last name and phone number.
Phone contact (This Application)
Users that provided their phone number might be contacted for commercial or promotional purposes related to this Application, as well as for fulfilling support requests.
Personal Data collected: phone number.
The services contained in this section allow the Owner to track and analyze the User response concerning web traffic or behavior regarding changes to the structure, text or any other component of this Application.
Google Website Optimizer (Google Inc.)
Google Website Optimizer is an A/B testing service provided by Google Inc.
Google may use Personal Data to contextualize and personalize the ads of its own advertising network.
This type of services allows you to view content hosted on external platforms directly from the pages of this Application and interact with them.
This type of service might still collect web traffic data for the pages where the service is installed, even when Users do not use it.
YouTube video widget (Google Inc.)
YouTube is a video content visualization service provided by Google Inc. that allows this Application to incorporate content of this kind on its pages.
Google Maps widget (Google Inc.)
Google Maps is a maps visualization service provided by Google Inc. that allows this Application to incorporate content of this kind on its pages.
Instagram widget (Instagram, Inc.)
Instagram is an image visualization service provided by Instagram, Inc. that allows this Application to incorporate content of this kind on its pages.
Vimeo video (Vimeo, LLC)
Vimeo is a video content visualization service provided by Vimeo, LLC that allows this Application to incorporate content of this kind on its pages.
Google Fonts is a typeface visualization service provided by Google Inc. that allows this Application to incorporate content of this kind on its pages.
Personal Data collected: Usage Data and various types of Data as specified in the privacy policy of the service.
TripAdvisor widget (TripAdvisor LLC)
TripAdvisor widget is a content visualization service provided by TripAdvisor LLC that allows this Application to incorporate content from that external platform on its pages.
Issuu widget (Issuu, Inc)
Issuu is a digital content visualization service provided by Issuu, Inc. that allows this Application to incorporate content of this kind on its pages.
YouTube video widget without cookies (Google Inc.)
This widget is set up in a way that ensures that YouTube won't store information and cookies about Users on this Application unless they play the video.
Personal Data collected: Usage Data.
This type of services allows this Application to monitor the use and behavior of its components so its performance, operation, maintenance and troubleshooting can be improved.
Which Personal Data are processed depends on the characteristics and mode of implementation of these services, whose function is to filter the activities of this Application.
Monitis (Monitis US LLC.)
Monitis is a monitoring service provided by Monitis US LLC.
This type of services allow interaction with social networks or other external platforms directly from the pages of this Application.
The interaction and information obtained through this Application are always subject to the User's privacy settings for each social network.
This type of service might still collect traffic data for the pages where the service is installed, even when Users do not use it.
Google+ +1 button and social widgets (Google Inc.)
The Google+ +1 button and social widgets are services allowing interaction with the Google+ social network provided by Google Inc.
Facebook Like button and social widgets (Facebook, Inc.)
The Facebook Like button and social widgets are services allowing interaction with the Facebook social network provided by Facebook, Inc.
Twitter Tweet button and social widgets (Twitter, Inc.)
The Twitter Tweet button and social widgets are services allowing interaction with the Twitter social network provided by Twitter, Inc.
LinkedIn button and social widgets (LinkedIn Corporation)
The LinkedIn button and social widgets are services allowing interaction with the LinkedIn social network provided by LinkedIn Corporation.
Pinterest "Pin it" button and social widgets (Pinterest)
The Pinterest "Pin it" button and social widgets are services allowing interaction with the Pinterest platform provided by Pinterest Inc.
Tumblr sharing button and social widgets (Tumblr Inc.)
The Tumblr sharing button and social widgets are services allowing interaction with the Tumblr social network provided by Tumblr Inc.
ShareThis (Sharethis Inc.)
ShareThis is a service provided by ShareThis Inc., which displays a widget that allows interaction with social networks and external platforms as well as sharing the contents of this Application.
Depending on the configuration, this service can display widgets belonging to third parties such as the managers of social networks where interactions are shared. In this case, also the third parties that provide the widget will be informed of interactions and Usage Data on the pages where this service is installed.
AddThis (Addthis Inc.)
AddThis is a service provided by Clearspring Technologies Inc., which displays a widget that allows interaction with social networks and external platforms as well as sharing the contents of this Application.
YouTube button and social widgets (Google Inc.)
The YouTube button and social widgets are services allowing interaction with the YouTube social network provided by Google Inc.
Managing contacts and sending messages
This type of services makes it possible to manage a database of email contacts, phone contacts or any other contact information to communicate with the User.
These services may also collect data concerning the date and time when the message was viewed by the User, as well as when the User interacted with it, such as by clicking on links included in the message.
MailChimp (The Rocket Science Group, LLC.)
MailChimp is an email address management and message sending service provided by The Rocket Science Group, LLC.
Platform services and hosting
These services have the purpose of hosting and running key components of this Application, therefore allowing the provision of this Application from within a unified platform. Such platforms provide a wide range of tools to the Owner – e.g. analytics, user registration, commenting, database management, e-commerce, payment processing – that imply the collection and handling of Personal Data. Some of these services work through geographically distributed servers, making it difficult to determine the actual location where the Personal Data are stored.
OVH is a platform provided by OVH that allows the Owner to build, run and host this Application. OVH is highly customizable and can host websites from simple blogs to complex e-commerce platforms.
Place of processing: Germany – Privacy Policy.
This type of service allows this Application and its partners to inform, optimize and serve advertising based on past use of this Application by the User.
This activity is performed by tracking Usage Data and by using Cookies, information that is transferred to the partners that manage the remarketing and behavioral targeting activity.
In addition to any opt out offered by any of the services below, the User may opt out of a third-party service's use of cookies by visiting the Network Advertising Initiative opt-out page.
Facebook Remarketing is a Remarketing and Behavioral Targeting service provided by Facebook, Inc. that connects the activity of this Application with the Facebook advertising network.
Facebook Custom Audience is a Remarketing and Behavioral Targeting service provided by Facebook, Inc. that connects the activity of this Application with the Facebook advertising network.
Personal Data collected: Cookies and email address.
AdWords Remarketing is a remarketing and behavioral targeting service provided by Google Inc. that connects the activity of this Application with the Adwords advertising network and the Doubleclick Cookie.
Remarketing through Google Analytics for Display Advertising (Google Inc.)
Google Analytics for Display Advertising is a remarketing and behavioral targeting service provided by Google Inc. that connects the tracking activity performed by Google Analytics and its Cookies with the Adwords advertising network and the Doubleclick Cookie.
Further information about Personal Data
The Service is not directed to children under the age of 13
Users declare themselves to be adult according to their applicable legislation. Minors may use this Application only with the assistance of a parent or guardian. Under no circumstance persons under the age of 13 may use this Application.
Selling goods and services online
The Personal Data collected are used to provide the User with services or to sell goods, including payment and possible delivery.
The Personal Data collected to complete the payment may include the credit card, the bank account used for the transfer, or any other means of payment envisaged. The kind of Data collected by this Application depends on the payment system used.
Receive their Data and have it transferred to another controller. Users have the right to receive their Data in a structured, commonly used and machine readable format and, if technically feasible, to have it transmitted to another controller without any hindrance. This provision is applicable provided that the Data is processed by automated means and that the processing is based on the User's consent, on a contract which the User is part of or on pre-contractual obligations thereof.
This Application uses Cookies. To learn more and for a detailed cookie notice, the User may consult the Cookie Policy.
The User's Personal Data may be used for legal purposes by the Owner in Court or in the stages leading to possible legal action arising from improper use of this Application or the related Services.
Additional information about User's Personal Data
In addition to the information contained in this privacy policy, this Application may provide the User with additional and contextual information concerning particular Services or the collection and processing of Personal Data upon request.
For operation and maintenance purposes, this Application and any third-party services may collect files that record interaction with this Application (System logs) use other Personal Data (such as the IP Address) for this purpose.
This Application does not support "Do Not Track" requests.
The Owner reserves the right to make changes to this privacy policy at any time by giving notice to its Users on this page and possibly within this Application and/or – as far as technically and legally feasible – sending a notice to Users via any contact information available to the Owner. It is strongly recommended to check this page often, referring to the date of the last modification listed at the bottom.
Information collected automatically through this Application (or third-party services employed in this Application), which can include: the IP addresses or domain names of the computers utilized by the Users who use this Application, the URI addresses (Uniform Resource Identifier), the time of the request, the method utilized to submit the request to the server, the size of the file received in response, the numerical code indicating the status of the server's answer (successful outcome, error, etc.), the country of origin, the features of the browser and the operating system utilized by the User, the various time details per visit (e.g., the time spent on each page within the Application) and the details about the path followed within the Application with special reference to the sequence of pages visited, and other parameters about the device operating system and/or the User's IT environment.
The individual using this Application who, unless otherwise specified, coincides with the Data Subject.
The natural or legal person, public authority, agency or other body which, alone or jointly with others, determines the purposes and means of the processing of Personal Data, including the security measures concerning the operation and use of this Application. The Data Controller, unless otherwise specified, is the Owner of this Application.
This Application
The service provided by this Application as described in the relative terms (if available) and on this site/application.
Small piece of data stored in the User's device.
This privacy policy relates solely to this Application, if not stated otherwise within this document.
Mira Conero Hotel Restaurant
Via Scossicci 16, 62017 Porto Recanati (MC) - Regione Marche, Italia
Tel.: +39 071 7501328 - Fax: +39 071 7504291
P.Iva: 01344680424 C.F.: LNRSRA54M19E690H
Policy in compliance with the article 13 of the legislative decree 196/2003.
The data you provide through this form are necessary to supply the booking service you require, they are processed in compliance with the security measures stated in the legislative decree 196/2003.
Your personal data will not be disclosed to third parties.
The data processor is Sauro Leonardi owner of Hotel Ristorante Mira Conero, whose main office is in Porto Recanati (MC), Via Scossicci 16.
HOTEL MIRA CONERO
via Scossicci 16, 62017 Porto Recanati (MC)
Fax.: +39 071 7504291
E-mail: info@miraconero.it
Informativa ai sensi dell'art. 13 D.Lgs. 196/2003
I dati forniti con il presente Form, il cui conferimento è facoltativo, ma necessario per fornire il servizio di prenotazione richiesto, sono trattati nel rispetto delle idonee misure di sicurezza previste dal D.Lgs. 196/2003.
I dati personali non saranno comunicati ad altri soggetti e non saranno diffusi.
Titolare del trattamento è Sauro Leonardi titolare dell'Hotel Ristorante Mira Conero con sede operativa in Porto Recanati (MC), Via Scossicci 16.
Prenota con WhatsApp
Richiedi informazioni o effettua una prenotazione con WhatsApp!
Inserisci il numero 327 736 0708 tra i tuoi contatti e potrai liberamente contattarci su WhatsApp 24/7
HOTEL MIRA CONERO via Scossicci 16, 62017 Porto Recanati (MC)Tel.: +39 071 7501328 Fax.: +39 071 7504291 E-mail: info@miraconero.it
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text:
package pipeline.branchpredictor;

import pipeline.ExecutionEngine;

public class AlwaysTaken extends BranchPredictor {

	public AlwaysTaken(ExecutionEngine containingExecutionEngine) {
		super(containingExecutionEngine);
	}

	@Override
	public void Train(long address, boolean outcome, boolean predict) {

	}

	@Override
	public boolean predict(long address, boolean outcome) {

		return true;
	}

}

redpajama_set_name: RedPajamaGithub


If you happened to run into a soothsayer recently who cautioned you to 'Beware the Ides of March' go home (if you're not already there), get back in bed, and hide under the covers until tomorrow. In the Shakespeare tragedy, Julius Caesar didn't heed the warning, and the next thing he knew Marcus Junius Brutus was stabbing him to death. The real Julius Caesar died on the Ides of March. He should have learned from Popeye the Sailor Man that it doesn't pay to have friends named Brutus!
It wasn't always a bad day. In ancient times, Kalends, Nones and Ides referred to dates in relation to lunar phases. 'Ides' referred to the first full moon of any particular month, usually falling around the 13th, 14th, or 15th of the month. But when Caesar was assassinated in 44 BC at the age of 55 the Ides of March became infamous.
It was bad enough that the Ides of March was his own personal worst day ever. But there are other reasons the Ides is a day to beware of. In 1781 1,900 British troops, vastly outnumbered by 4,400 American troops tounced the colonists at the Battle of Guilford Courthouse in North Carolina. In 1889 a cyclone destroyed three US war ships and three German ones in Samoa, killing 200 sailors. In 1917 Czar Nicholas II abdicated on the Ides of March. Just over a year later he and his family were executed by a firing squad.
Minnesota and North Dakota were devastated by a blizzard on the Ides of march in 1941, leaving 40 dead. Two years earlier Hitler chose the Ides of march to invade Czechoslovakia. On the same day in 1938 he took away Jews' right to vote.
The Ed Sullivan show was cancelled by CBS on the Ides of March in 1971. Oh noooo, Eddie... Topo steel loves you... Eddie, kiss me goodnight!"
The World Health Organization warned the world of an outbreak of SARs on the Ides of March in 2003. IOn the Ides of March in 1988 NASA announced the NASA reports that the ozone layer had been depleted three times faster than predicted over the Northern Hemisphere. That same year the Saint Louis Cardinals moved to Phoenix. You might say they chose the Ides to march.
In 2011 the Syrian Civil War began on... you guessed it! The Ides of March.
It hasn't been all bad. In 1493 Columbus triumphantly returned to Spain, and in 1820 Maine became a state. On the Ides of March in 1869 the Cincinnati Red Stockings became the very first professional baseball team, and Rolls Royce was founded on the Ides of March in 1906.
And for those of us addicted to our phones and tablets, the very first domain name was registered for use on the World Wide Web (aka: www) - symbolics.com was the first.
Although, come to think of it there are many people -- mostly parents who can't get their kids eyes off the little screens -- who probably consider that another example of why the Ides of March has come to represent very bad luck indeed.