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Ian Clunies Alsop (* 14. Juni 1943 in Wembley) ist ein ehemaliger britischer  Bahnradsportler und späterer mexikanischer Radsporttrainer und Fahrradrahmenbauer.

Sportliche Laufbahn
Schon als Junior belegte Ian Alsop bei britischen Bahn-Meisterschaften Podiumsplätze. Zwischen 1962 und 1968 errang er insgesamt fünf britische Meistertitel in den Disziplinen Tandemrennen und Zweier-Mannschaftsfahren sowie mehrfach Plätze unter den ersten Drei. Bei den British Empire and Commonwealth Games 1966 in Kingston siegte er im Scratchrennen über zehn Meilen und belegte im 1000-Meter-Zeitfahren Platz sieben.

Alsop startete auch bei UCI-Bahn-Weltmeisterschaften, im Sprint wie in der Mannschaftsverfolgung, errang jedoch keine Podiumsplätze. 1968 nahm er an den Olympischen Spielen in Mexiko-Stadt teil und startete dort im Sprint und in der Mannschaftsverfolgung, blieb aber ohne Medaille. Ab 1966 versuchte er sich auch als Steher, war aber nicht so erfolgreich wie in anderen Bahndisziplinen. 1967 gewann er im Vorabendprogramm des Sechstagerennens von London das Londoner Amateur-Sechstagerennen mit seinem Partner Tony Gowland.

Nach einem Streit mit dem britischen Radsportverband British Cycling Federation beendete Ian Alsop 1968 seine Radsportlaufbahn und wanderte nach Mexiko aus. Dort war er zunächst als National-Bahntrainer tätig. Er baut Fahrradrahmen für das US-amerikanische Unternehmen Raysport. Alsop fährt für Mexiko weiterhin Rennen in der Masters-Klasse. Bei den Huntsman World Senior Games gewann er 2002 in der Altersklasse 55–59 Gold mit dem Mountainbike.

Erfolge
1962
  Britischer Amateur-Meister – Tandemrennen (mit Roger Whitfield)
1966
  Commonwealth Games – Scratch (10 Meilen)
  Britischer Amateur-Meister – Zweier-Mannschaftszeitfahren (mit Tony Gowland), Scratch (10 Meilen)
1967
  Britischer Amateur-Meister – Scratch (10 Meilen)
1968
  Britischer Amateur-Meister – Tandemrennen (mit Geoff Cooke)

Familiäres
Alsop heiratete Jean Dunn, die mehrfache britische Meisterin im Radsport war.

Weblinks

 Ian Alsop auf hetchins.org

Einzelnachweise

Teilnehmer der Olympischen Sommerspiele 1968
Radsportler (Großbritannien)
Bahnradfahrer
Olympiateilnehmer (Vereinigtes Königreich)
Sieger bei den Commonwealth Games (Radsport)
Radsportler (Mexiko)
Radsportnationaltrainer (Mexiko)
Brite
Mexikaner
Geboren 1943
Mann


Here's our street style edit of the best dressed men and women spotted in the Birdcage at Melbourne Cup 2015.
Here's our street style edit of the best dressed men and women at Derby Cup 2015.
Here's our street style edit of the best dressed men and women at Caulfield Cup 2015.
TheTrendSpotter picks the best street style looks from Paris Fashion Week Spring 2016.


A decades-old electoral law provision, in which no one is allowed to drink alcoholic beverages during general elections and primary events, was revoked before this Sunday's GOP Primary. The Government of Puerto Rico decided that the status known as "Ley Seca" or Non Drinking Electoral Disposition Law, was not to apply to the Republican Party's Presidential Primary to be hold on Sunday.
According to current law in Puerto Rico, a U.S. territory in the Caribbean, alcohol consumption is banned during electoral events, including general elections. The law is known as "Ley Seca," which stands for No Drinking Law. The law says that no one is allowed to drink during the electoral event, and that no business – supermarkets, bars, pubs, sport venues, etc. – will be allowed to sell, serve, or consume alcoholic beverages between midnight and 9:00 PM on the day of the electoral event. If caught disobeying the law, individuals can be punished with up to 60 days in jail, though it does not apply to tourist-designated areas like hotels and resorts owned by the Puerto Rico's Tourism Company.
While the decades-old law has been questioned and called archaic given today's standards, the Government of Puerto Rico will still observe the legal process for the fairness of every electoral candidate participating in the GOP Primary happening on Sunday.
Some business partnerships are requesting that Governor Alejandro Garcia Padilla halt the anti-drinking law provision of the electoral law. A major sporting event was told they can't sell alcoholic beverages on Sunday, causing the organizers to cancel several events. The Governor claims that under the Commonwealth's Electoral Law, the only way it can be halted is by passing an amendment.
The Republican Party leadership on the island has said that while they believe the elections have to be held in fairness with the Electoral law, they believe that the drinking law is unnecessary as it takes away police resources in an effort to ban excessive drinking during the electoral process.
The law provision can also apply during non electoral related events and emergency situations on the island, like during a hurricane or earthquake, as part of the Governor's executive orders request. It can then be revoked after the emergency has been suspended.


Former Vice-President Kwesi Amissah-Arthur has criticized the New Patriotic Party administration for its management of the economy.
He says the NPP government could have done much better in one year and that is what as Ghanaians we are all hoping for in the coming years for them to be able to resolve the problems.
The former Vice President made the statement in Ho on Christmas Day, 25th December, 2017 when he spoke to the media after donations to children on admission at the Ho Regional and Municipal hospitals with his wife, Matilda Amissah-Arthur.
Mr Amissah-Arthur said that most of the programmes of the immediate past National Democratic Congress government that have been adopted and implemented by the NPP government are without the full conceptualization and appreciation of the cost involved.
Mr Amissah-Arthur gave as example, the free SHS which he said is a problem and require more expert consultations to better define goals and outcomes.
The couple was accompanied by the NDC MP for the Area, Benjamin Kpodo and went round the various wards to interact with patients on admission and to wish them well.
They presented assorted gifts such as fruits, drinks, biscuits, cooking oil and bags of rice to the children's ward and staff of the hospital.


It might not be so obvious these days but the design and making of furniture is at the core of Wilkins and Kent. We still have the workshop and we are still hard at work making our special pieces for all our customers (quite a few are regulars over the years as they collect a household of Wilkins and Kent Furniture.
As we have grown, our furniture making has been structured along two paths. We have several standard lines although they are still mostly made to order, such as the signature CD/DVD cabinet, Hifi and wine cabinets, beds and bookcases. Added to that are our solid timber pieces such as the beautifully crafted tables and buffets. Always a strong part of the business has been our built in furniture such as large bookcases, storage areas and wardrobes.
Most of our standard pieces have PDF's available showing the prices for different sizes and configurations. If you are interested in any other furniture please drop into the shops or send us an email to discuss your ideas.


A few years back, when I first designed the Geek Cave Creations website, I received a lot of spam emails through the contact page that I had made, which at the time had no Human Verification protection. In short order, I started looking into CAPTCHA scripts, but couldn't find one that I was able to easily figure out (after all, if I can't read it, maybe other's can't either), so I wrote my own. This first script still used the same old tactic of randomly placed letters for the user to decipher, though it varied the number of characters, along with the font, angle, color and placement of each letter, adding randomly generated noise and a gradient background, to make it harder for the bot scripts to crack. It seemed like it was better than what I had seen out there at the time, and it did the job quite well.
The only problem was, I still had a hard time reading the characters in the output image from time to time. So I considered the idea a bit more, and came up with a different method.
The idea here was to get rid of all those difficult to read letters, and replace them with something that even a 5 year old could recognise, yet would be difficult for a bot script to figure out. The real "trick" to this isn't so much in defeating the bot script's Object Recognition, since Object Recognition is nearly as advanced as Character Recognition. The "trick" here is to give the bot scripts as little "free access" to the images as possible. Most bot scripts don't rely on cracking every single image that they come across. They rely on matching the current image with one that was previously cracked, and using the results from the previous image. Needless to say, this is the area where I've concentrated on improvement. After all, pretty pictures are nice, but they do no good at all if a bot script can crack them without any effort.
The image above still "looks" like a CAPTCHA image, but all it really is is a randomly generated image, made to keep bot scripts happily working away on something that does absolutely nothing. This is something that's enabled in all versions of the CAPTCHA4us scripts, and the Deluxe package takes this a step further, with IP logging (so that you can note repeat offenders, and possibly report them), and other methods that I don't exactly think I want to be made public. As an added, extra security measure, the Deluxe CAPTCHA4us script package will come as a pre-compiled executable file that will run on *nix or Win32 systems (your choice; both files will be included), to prevent bot script owners from purchasing the package and reverse-engineering the code quite so easily. and since the Deluxe package uses a completely different code base, and different methods of security measures, getting the Free package won't help the bad guys deal with the Deluxe package at all.
- To process transactions,	We may use the information Users provide about themselves when placing an order only to provide service to that order. We do not share this information with outside parties except to the extent necessary to provide the service.
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This license shall automatically terminate if you violate any of these restrictions and may be terminated by CAPTCHA4us.com at any time. Upon terminating your viewing of these materials or upon the termination of this license, you must destroy any downloaded materials in your possession whether in electronic or printed format.
The materials on CAPTCHA4us.com's web site are provided "as is". CAPTCHA4us.com makes no warranties, expressed or implied, and hereby disclaims and negates all other warranties, including without limitation, implied warranties or conditions of merchantability, fitness for a particular purpose, or non-infringement of intellectual property or other violation of rights. Further, CAPTCHA4us.com does not warrant or make any representations concerning the accuracy, likely results, or reliability of the use of the materials on its Internet web site or otherwise relating to such materials or on any sites linked to this site.
In no event shall CAPTCHA4us.com or its suppliers be liable for any damages (including, without limitation, damages for loss of data or profit, or due to business interruption,) arising out of the use or inability to use the materials on CAPTCHA4us.com's Internet site, even if CAPTCHA4us.com or a CAPTCHA4us.com authorized representative has been notified orally or in writing of the possibility of such damage. Because some jurisdictions do not allow limitations on implied warranties, or limitations of liability for consequential or incidental damages, these limitations may not apply to you.
The materials appearing on CAPTCHA4us.com's web site could include technical, typographical, or photographic errors. CAPTCHA4us.com does not warrant that any of the materials on its web site are accurate, complete, or current. CAPTCHA4us.com may make changes to the materials contained on its web site at any time without notice. CAPTCHA4us.com does not, however, make any commitment to update the materials.
CAPTCHA4us.com has not reviewed all of the sites linked to its Internet web site and is not responsible for the contents of any such linked site. The inclusion of any link does not imply endorsement by CAPTCHA4us.com of the site. Use of any such linked web site is at the user's own risk.
Any claim relating to CAPTCHA4us.com's web site shall be governed by the laws of the State of Nevada without regard to its conflict of law provisions.


text:
MiWay sponsors 40th Wally Hayward Marathon
2016 is shaping up to be a big year, MiWay Insurance and MiWayLife announce their second sponsorship deal this year with the Wally Hayward.
MiWay has been announced as the title sponsor of the 40th Wally Hayward Marathon, taking place at Hoërskool Zwartkop in Centurion on 2 May 2016.
Earlier this year, MiWay and MiWayLife announced their three year partnership with B-Active Sports, organisers of the ULTRA Triathlon Series, which kicks off on 6 March in KZN.
Head of Marketing and Brand at MiWay, Nthabiseng Moloi says: "We are delighted to be partnering with the Wally Hayward Marathon. This is part of our ongoing quest to support home-grown events that give athletes the freedom to showcase their talent and improve their performance in order to compete in other iconic events".
The 40th Wally Hayward Marathon will be held in honour of one of South Africa's greatest long distance runners. Hayward's exceptional running career spanned six decades. He represented South Africa at the Olympic Games and is best remembered for his remarkable achievements in the Comrades Marathon, which he won five times and ran at the ages of 79 and 80.
"We are extremely proud, as well as excited, to be partnered with MiWay Insurance who share the same passion for service excellence and a client satisfaction as we do," says Francois Jordaan, Chairman of Alpha Centurion Runners and Walkers.
MiWay recently extended membership in its ASA-registered running club – MiWay Warriors – to its clients and their friends and family at no cost. "Our increasing involvement in sports is part of our commitment to fostering a healthy and balanced lifestyle - not only for our staff, but for our clients too," says Moloi.
The 40th Wally Hayward Marathon comprises a 42.2km marathon, a 21.1km half marathon, a 10km road race and a variety of fun runs. The event caters for the whole family with fun activities planned for kids.
Online registrations for the marathon are now open, and more race information can be found at www.wally.co.za. Comrades Marathon personnel will also be on hand to provide qualifying athletes with information.
No tag selected
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redpajama_set_name: RedPajamaCommonCrawl


text:
Newport News Authenticates Keel for US Navy Sub Arkansas
(Photo: HII)
HII's (NYSE: HII) Newport News Shipbuilding (NNS) division hosted a keel authentication ceremony for Virginia-class submarine Arkansas (SSN 800).
The ship's sponsors are the six women of the historic group known as the Little Rock Nine, the first African American students to attend all-white Central High School in Little Rock, Arkansas during desegregation. NNS honored all nine members, including the three men, during Saturday's ceremony.
The Little Rock Nine made history in 1957 with their response to the Supreme Court ruling in Brown v. Board of Education, declaring racial segregation in public schools unconstitutional. Faced with shouting mobs, threats of violence and hostile state leaders who blocked their way, the teenagers were escorted into the school by federal troops at the direction of President Dwight D. Eisenhower.
"Their courageous spirit will forever inspire Arkansas and her crew. This group forever changed our nation's history and their submarine will help ensure their legacy continues," NNS President Jennifer Boykin said. "The bravery and resilience of the Little Rock Nine sparked a fire of change and demonstrated the strength of blending different perspectives and backgrounds. We harness this strength in the shipyard every day. Our diversity allows us to extend beyond our own limits, to reach new heights, and build each boat even better than the one before it. Arkansas will be proof of this power."
During Saturday's ceremony, NNS welders etched a historic six sets of initials of the Little Rock Nine onto metal plates, signifying the keel of SSN 800 as being "truly and fairly laid." The metal plates will remain affixed to the submarine throughout its life.
"(Former Navy) Secretary Ray Mabus asked us to be supporters of the ship and its crew. I signed on to be a foster grandmother," said Elizabeth Eckford, a member of the Little Rock Nine, who spoke on behalf of the group during the ceremony. "President Eisenhower sent 1,000 paratroopers to Little Rock to disperse a mob, bring order, and they made it possible for us to enter Central High School. From that point, I've had very high regard for specially trained forces."
Arkansas is the 27th Virginia-class fast attack submarine being built under the teaming agreement with General Dynamics Electric Boat.
"With advances in sound silencing, acoustic sensors, and weapons delivery systems, Arkansas will traverse the world's oceans and seas as an apex predator. Representing our asymmetric advantage in the undersea domain, the Arkansas will have no equal," said Vice Adm. William Houston, commander, Naval Submarine Forces.
"It is an incredible honor for the crew to begin to establish the relationship with our namesake state of Arkansas as well as with the ship's sponsors," said Cmdr. Adam Kahnke, commanding officer of the pre-commissioning unit. "The story of the Little Rock Nine demonstrates the power of perseverance in the face of adversity. I find the relationship with the ship's sponsors very appropriate due to the fact that perseverance is an essential attribute to success in the art of submarine warfare."
NNS is one of only two shipyards capable of designing and building nuclear-powered submarines. The advanced capabilities of Virginia-class submarines increase firepower, maneuverability and stealth.
This milestone on Arkansas comes following the delivery of USS Montana (SSN 794), the launch of New Jersey (SSN 796), and continued progress on Massachusetts (SSN 798) at NNS earlier in 2022, as the shipyard continues to invest in its workforce and facilities to make steady progress on delivering these important assets to the Navy.
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New Balance Msx90pnb Grey/Yellow - Jim P.
New Balance draw their inspiration from the '90s with the MSX90PNB Sneakers. This chunky sneaker is made with an upper part in one piece suede, which secures the right comfort. Furthermore the sneaker has a reflective "N" on the sides, a ultra soft REVLite sole and X-90 branding on the tongue.


text:
Saint-Laurent-les-Églises è un comune francese di 866 abitanti situato nel dipartimento dell'Alta Vienne nella regione della Nuova Aquitania.

Società

Evoluzione demografica

Note

Altri progetti

Saint-Laurent-les-Eglises

redpajama_set_name: RedPajamaWikipedia


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Could the next generation of killer diseases come from the family pet? Scientists say cats and dogs 'large potential source' of diseases that could hit mankind
By Mark Prigg
Published: 11:48 EDT, 12 November 2012 | Updated: 12:33 EDT, 12 November 2012
A new generation of killer diseases set to hit mankind could come from cats and dogs, a study has found.
Scientists say human beings will soon be infecting serious illnesses which have spread from their domestic pets.
A report found the risk to humans from animal-based 'emerging diseases' has increased as pets have moved 'out of the barn' and into homes.
Researchers say that domestic pets such as this Afghan Hound could be the source of the next major diseases to jump between animals and humans.
It says people are becoming more and more at risk because pets are increasingly part of their owner's lives - including sleeping in their bedrooms.
The report says diseases in humans started by animals will be increasingly virulent - like canine rabies which kills around 55,000 people in Africa and Asia each year.
It calls for global monitoring of these 'zoonotic' diseases - spreads from animals to humans - so medicines and vaccines can be developed.
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The study was led by Michael Day, Professor of Veterinary Pathology in the School of Veterinary Sciences at the University of Bristol and published in journal Emerging Infectious Diseases,
He says cats and dogs are a 'large potential source' of the new generation of diseases set to hit mankind.
Professor Day said: 'The number of small companion animals is significant.
For example there are an estimated eight to ten million dogs living in up to 31 per cent of UK homes and in the USA, 72 million dogs in 37 per cent of homes.
'In developed countries the relationship between man and dogs and cats has deepened, with these animals now closely sharing the human indoor environment.
'The benefits of pet ownership on human health, well-being and development are unquestionable, but as dogs and cats have moved from the barn, to the house, to the bedroom, the potential for disease spread to humans increases.'
Researchers say the increased number of owners who sleep with their pets has increased the risk of diseases spreading from them to their owners
The report was backed by The World Small Animal Veterinary Association (WSAVA), One Health Committee, the US Centres for Disease Control and Prevention (CDC), the World Organisation for Animal Health (OIE) and the World Health Organization (WHO).
The report said international health agencies largely monitor diseases spread by livestock - not domestic pets.
Professor Day added: 'For example, the WHO monitors human influenza virus infection through a network of 111 centres in 83 countries.
'In contrast, there is no such monitoring for the infections that may be transmitted between small companion animals and man.'
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SpaceX says a leaky valve was to blame for Crew Dragon explosion in April, as VP admits firm's plan to fly with astronauts on board this year has become 'increasingly difficult'
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Someone Just Pointed Out How Messed Up New Orleans Map Is And Now We Can't Unsee It
by admin · Published March 28, 2018 · Updated March 28, 2018
Last week, James L. Sutter, a 34-year-old game designer and author, took to Twitter to share his hilarious tongue-in-cheek critique on the real map of New Orleans.
Sutter, best known as the co-creator of the Pathfinder Roleplaying Game, an expansion to Dungeons and Dragons 3rd edition, took a look at New Orleans as if it were a fantasy map, designed and submitted by a freelancer.
Playfully highlighting some seemingly nonsensical bridge placement, and the fact that Lake Borgne doesn't appear to be a lake at all, the cartography of Louisiana's largest city was quickly picked apart by the author. He concluded that it is a "really interesting-looking design, but in the end, it's just not believable. Please clean up your map and resubmit when it follows the rules of a real-world city".
We guess that whoever "designed" the map for New Orleans was tripping on something, but doesn't it look like an interesting place to go and check out? What can be cooler than a place that, according to Sutter, is stranger than fiction? Scroll down below to check out his 'critique' for yourself, and let us know what you think in the comments!
More info: Twitter
Last week, game designer James L. Sutter took to Twitter to share his critique on the real map of New Orleans
Sutter is best known as the co-creator of the Pathfinder Roleplaying Game
Having the expertise on fictional map creation, the author criticized it's many seemingly nonsensical parts
Like this canal that is perfectly linear…
Or why is Lake Borgne called 'lake' when it's technically a lagoon?
And then the placement of Lake Pontchartrain Causeway that expands for 24 miles (38km)?
Sutter elaborates on the texture of the swamps of Louisiana, pointing out that no cartographer would work on replicating it
While admitting that the design is quite interesting, James Sutter concludes that the map is simply not believable
He jokingly recommends the South to rework the map of New Orleans and resubmit it when it looks like a real city
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Tag Archives: love story
Feb 17, 2012 · 9:45 am
Pagliacci at the Edinburgh Fringe – but will laughter get women into bed?
Giacinto Palmieri in Pagliacci costume
As mentioned in my blog yesterday, I had a drink with Italian-born British-based comedian Giacinto Palmieri – after seeing the first try-out of his show Pagliaccio which he will be performing at the Edinburgh Fringe in August.
Giacinto is one of life's natural quotables:
"It's a love story," he says, "but it's a double love story because it's also a love story for the Edinburgh Fringe itself.
"The Fringe is an intense experience. It is like those war veterans who spend the rest of their life talking about what they did in the War. People think Why? The War is a horrible thing – but it's the intensity they are missing. Once you have done the Edinburgh Fringe, the rest of your life just looks bland."
This will be Giacinto's fourth year at the Fringe.
"This is my first attempt to do a thematic narrative show," he told me in a Soho pub. "I was doing joke-joke-joke comedy but, as a member of the audience, I started to discover and love thematic shows. There was a mis-match between what I was doing and what I really like. So I set myself the goal of writing a thematic show.
"Edinburgh is such a strong experience, it really stimulates your writing. I started to write this year's Edinburgh show the day after the Fringe finished last year; some material I even wrote during Edinburgh itself. I wanted to start writing fresh from the Edinburgh experience without waiting for January or February like most comedians."
"Most comedians seem to start writing around 25th July!" I said.
"Yes," he laughed. "Or on the train up to Edinburgh! It's true."
"But I really wanted to express the intensity of being there and the fact that people are up in Edinburgh to express their emotions, so anything can happen there. Once you open the bottle, you don't know what comes out. Once you go there to express yourself every day for three-and-a-half weeks, you don't know what you will discover about yourself.
"My show is about comedians living together and sharing a show and working together and it is a true story of unrequited love and jealousy between the comedians and I play with the similarity between that situation and the plot of the opera Pagliacci which is about a travelling group of clowns.
"So it is a love story about another performer I became romantically interested in at last year's Fringe, but also about the craziness and intensity of the Fringe itself."
"The Pagliacci cliché," I said to Giacinto, "is that all clowns are sad."
"There is clearly some truth in that cliché," he replied. "One of the best responses I have ever seen on the comedy circuit was when a comedian asked a member of the audience What do you do for a living? and the reply was I'm a therapist and the comedian simply asked So why am I doing this?
"You do need to wonder why we are all doing this."
Giacinto has been in the UK for eleven years (and is now a British citizen) but he has only been performing comedy for the last four years. Before that, he was a full-time I.T. consultant. That seems a bit weird to me – coming to a foreign country, pursuing your career for seven years, then becoming a stand-up comic.
"It is even weirder than that," he tells me. "The first time I went to Edinburgh was as a member of the audience. I absolutely loved it and saw 30 or 40 theatre shows but only one comedy show which I did not even like. So I did not know comedy at all. I discovered it later. I was in a pub in London and saw there was a comedy show upstairs and I went and I was mesmerised because I discovered how much creativity and energy there was in it. It looked very fresh. I was fascinated by that level of comedy, not by the professional level on TV.
"When I started, my models were the comedians who were one or two levels above me on the London circuit, not the Big Names.. I discovered the Big Names quite late.
"I had always liked writing. I started writing a fake, mock anthropological study of the British tradition of the corporate Christmas party and – completely by mistake – I emailed it to the MD of my company and he liked it so much he read it in front of everybody during the Christmas party. And it worked very well. People liked it. People laughed. But he did not mention my name. He thought he was protecting me. But I would have liked the recognition.
"So, at the same time, I discovered the comedy club scene on the one hand and my comedy writing instinct on the other hand. I put the two things together. I thought why not take my material and convert it into a stand-up comedy form and perform it myself?"
"But," I asked Giacinto, "people from I.T. have a different mindset to comedians, don't they?"
"Well," he explained, "people in I.T. are interested in recursion and self-referential paradoxes like Bertrand Russell's – the paradox of the infinite sets."
"Ah, of course," I said, nodding sagely and hoping Wikipedia had an entry I could look up later.
"Philosophy," Giacinto continued, "is what I studied at University, so there is a connection between my interest in logic and philosophy which can be brought into the I.T. arena because computer programming is applied logic and many jokes are based on paradoxes and self-reference. So, if you like logic, you will probably like word gaming, paradoxes and so on.
"That is why, until now, as a comedian I have always been very academic, very much inside my head, very much philosophical – it has been about language and so on. Which, of course, is very much part of my personality and my way of looking at things.
"The fact that English is not my native language is a difficulty – an obstacle of sorts – but it is also a great opportunity, because you can play with it. I can see in the English language things which a native speaker cannot see. Every foreigner is able to see cultural things which a native cannot see.
"Most foreign comedians in Britain are foreigners but still native English-speakers. They are Australians, Americans, New Zealanders and so on. I have the advantage, as a non-native English speaker, of being not only able to see British culture but the English language itself from a fresh point of view.
"I played with that as part of my act for a long time. This new show Pagliaccio does not play with language so much. It is a love story, so is more universal.
"My comedy was very abstract, so I decided to try to be more personal, to go more into the emotional side of things. And people told me one of the reasons I always had problems with women was because I am too much inside my own head.
"It is true comedy is a journey of self-discovery, in a sense. I am trying to discover the emotional side of me. It is frightening. Once you open the bottle, you don't know what kind of genie will come out. It might be a good genie or a bad one."
"One great cliché," I suggested, "is that the way to get a woman into bed is to make her laugh."
"Well, it hasn't worked for me!" laughed Giacinto.
"The comedian Andrew Watts – a very very clever guy – wrote an article. His theory is that women use laughter as a way to communicate a sexual interest in somebody. In a comedy club situation, maybe onstage I can get a bigger laugh than a very good-looking comedian but, if you go for drinks with the girls afterwards, I am pretty sure the good-looking comedian will get bigger laughs in the bar. Pretty sure. Because women are sending signals.
"Getting a woman into bed by making her laugh… That was my hope, but I lost that hope: I don't think it's going to work for me."
"The press will love your show in Edinburgh," I told Giacinto: "A love story with laughs actually set during last year's Edinburgh Fringe."
"Perhaps," he mused.
"Maybe you should call it Pagliacci – An Edinburgh Fringe Love Story," I suggested.
"Perhaps," he mused. "Perhaps. Perhaps women will like it."
Filed under Comedy, Edinburgh, Italy, Philosophy, Sex, Uncategorized
Tagged as Andrew Watts, Bertrand Russell, british, comedy, edinburgh, English, festival, Fringe, Giacinto Palmieri, infinite sets, Italian, language, love story, Pagliacci, paradox, sex


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Nearly three years after a deepwater well rupture killed 11 men, sank a rig and spewed 4 million barrels of oil into the Gulf of Mexico, BP and the other companies involved are about to face their day in court.
The trial over the worst U.S. offshore oil spill is set to start this morning in New Orleans before a federal judge and without a jury. Few expect the case, seen lasting several months, will be decided by the judge.
Efforts to pull together an eleventh-hour settlement over the weekend did not result in a deal, but legal experts expect a resolution, at least with the U.S. Department of Justice, in the coming months. Early testimony is likely to set the tone for any settlement talks, depending on how damaging the evidence is, the experts said.
Joining well owner BP Plc in Judge Carl Barbier's courtroom will be rig owner Transocean Ltd and well cement services provider Halliburton Co .
The stakes are higher this time, though. The Macondo well explosion and spill on April 20, 2010, affected five state coastlines, prompted a six-month ban on oil and gas drilling in the Gulf, and disrupted the livelihoods of fishermen, hoteliers and others.
BP has spent or committed $37 billion on cleanup, restoration, payouts, settlements and fines. That includes $8.5 billion to most plaintiffs, a record $4.5 billion in penalties, and a guilty plea to 14 criminal counts to resolve criminal charges from the Justice Department and civil claims from the U.S. Securities and Exchange Commission.
But the company could end up paying tens of billions more, depending on whether the U.S. government, Gulf states and plaintiffs convince Judge Barbier that BP was grossly negligent.
A finding of gross negligence would open the door to punitive damages against BP, Transocean and Halliburton.
The first phase of the trial, expected to last several months, will focus on the level of negligence as well as apportion blame between the defendants.
The second phase, slated for September, will focus on the flow rate of the oil that spewed from the well. The third phase in 2014 will consider damages.


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text:
Michael Ray to Fans, Family After DUI Arrest: 'I Am So Very Sorry'
Wendy Hermanson Published: December 22, 2017
Michael Ray has released a statement after being arrested early Wednesday morning (Dec. 20) for driving while intoxicated, and he says he's sorry.
"I want to apologize to my fans, family, and my hometown community for placing myself in this situation," he notes. "I am so very sorry for the disappointment these events have caused everyone. I know it will take time; however, I will do everything I can to rebuild your trust."
Ray was also in possession of marijuana when police picked him up at a McDonald's in Eustis, Fla. He was released from the Lake County Jail earlier in the day, where he was being held on $6000 bond.
Police say Ray crashed his 2012 Jeep into the car in front of him in the McDonald's drive-thru line around 4AM. The Orlando Sentinel quotes the arrest report — Ray says his foot slipped off the pedal, causing him to hit a 2016 blue Toyota Scion in front of him.
Police also found a bottle with liquid, which Ray said was his "weed oil." He has a court date set for Jan. 18. The possession of marijuana charge was for "THC Hash Oil."
The 29-year-old's real name is Michael Ray Roach and Eustis, Fla., is his hometown. His hits include "Kiss You in the Morning" and "Think a Little Less." Earlier this year he released a song called "Get to You" from an upcoming second studio album. He closed the year with Dustin Lynch on the Ride or Die Tour and with news that he'd been named one of the 2018 CRS New Faces.
More Country Artists' Mug Shots
Source: Michael Ray to Fans, Family After DUI Arrest: 'I Am So Very Sorry'
Luke Combs Reveals His New Album's Title and Cover Artwork
Luke Combs, Brandi Carlile to Perform at the 2023 Grammy Awards
Luke Bryan, Shania Twain, Zac Brown Band Head Up 2023 Faster Horses Festival
Did Carly Pearce Just Admit to Bribing a Cop?
CMT Reveals 2023 Next Women of Country
How to Watch Lisa Marie Presley's Public Memorial Service
Hardy Invites Morgan Wallen for Reminiscent 'Red' From New Album [Listen]


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text:
Q: How to prevent http caching for javascript modules? A brief introduction
First of all, I know, the question is often asked and I have read many discussion before asking.
Tipical approches to handle the cache problem that are suggested in other question are:

*

*Versioning js files in this way: <script src="/myJavascript.js?version=4"></script>. See Keparo's answer here.

*Create a rewrite rule on the web server in this way: RewriteRule ^(.*)\.[\d]{10}\.(css|js)$ $1.$2 [L]. See Kip's answer here.

Context description
Currently I'm refactoring my old php code running on apache2, introducing an heavy layer of js/jquery to handle the frontend and decoupling FE and BE building some api.
The js project is organized in this way:
my-project/
├── main.js
├── main.css
├── main.php
├── js/
│   ├── JsClass1.js
│   └── JsClass2.js
└── src/
    └── php_code/
        ├── class1.php
        └── class2.php

My problem
I don't know how to avoid that js classes are cached from web browser because the previous solution describer in the description are not feasible.
Just to make a brief example of my problem this is a portion of code that gives me problems:
main.js
//Import my js classes
import JsClass1 from './js/JsClass1.js';
import JsClass2 from './js/JsClass2.js';

//Instantiate js objects
const j1 = new JsClass1();
const j2 = new JsClass2();

//Use js object
j2.do_stuff();
j2.do_stuff();

JsClass1.js
import JsClassN from "./JsClassN.js";

export default class JsClass1 {
    constructor(var1) {
        //Create stuff
    }

    do_stuff() {
        //Doing real stuff
    }

}

main.php
<!DOCTYPE html>
<html lang='it-IT'>
<head>
    <script type='module' src='/main.js?ver=<? echo  getVersion(); ?>' type='text/javascript'></script>
</head>
<body>
...
</body>

Wrap up
How can I handle those js imports and avoid that browser caches old classes when I release in production new versions?
Do I need to reorganize my code structure to achieve this? And if so, what's the best approach?

redpajama_set_name: RedPajamaStackExchange


Below is information describing the California Community Colleges Classified Senate and its history. The organization is also known as "4CS" or "CCCCS". If you do not find what you're looking for, please contact Jim Wilson, President Emeritus and request assistance.


text:
Advisory Board Groups
Center Partners
User Experience and Expectation Research (R1)
Social and Cultural Design Research (R2)
Inclusive Emergency Lifelines (D1)
Wireless Connected Devices (D2)
App Factory (D3)
TRAINING / DISSEMINATION
Capacity Building and Training (T1)
Policy and Outreach Initiatives To Accelerate Adoption (DS1)
Publications / Presentations / Products
RE: Wireless - Consumer Newsletter
TDPH Monthly Newsletter
Papers Archive 2001-2016
Policy Filings
Wireless RERC News
Publications / Reports
Wireless Industry Updates
Wireless RERC
About the Georgia Institute of Technology
The Georgia Institute of Technology is one of the nation's top research universities, distinguished by its commitment to improving the human condition through advanced science and technology. As a leading technological university, Georgia Tech stands out as a distinctively different kind of university, one that is eagerly encouraging and developing the revolutionary technologies of the 21st century with more than 100 centers focused on interdisciplinary research that consistently contribute vital research and innovation to American government, industry, and business. Its campus occupies 400 acres in the heart of the city of Atlanta, where 20,000 undergraduate and graduate students receive a focused, technologically based education. Accredited by the Southern Association of Colleges and Schools (SACS), the Institute offers many nationally recognized, top-ranked programs. Undergraduate and graduate degrees are offered in the Colleges of Architecture, Computing, Engineering, Scheller College of Business, Sciences and the Ivan Allen College of Liberal Arts.
About the Center for Advanced Communications Policy
The Center for Advanced Communications Policy (CACP) focuses on key issues that influence the development, implementation and adoption of cutting-edge, advanced communications technologies. CACP work includes assessment of policy issues and production of regulatory filings, identification of future options for innovation, and articulation of a clearer vision of the ever-changing technology landscape. Center research areas include wireless communications and platforms; accessible technology design and use for people with disabilities; emergency alerts and communications; higher education policy and evaluation; workforce development and employment for people with disabilities; new communications modes such as social media and online participatory platforms; STEM (science, technology, engineering, and mathematics) education, and the cultural impact of technology shifts. CACP, in its role as an objective and neutral source, collaborates with government, industry and academia at the national, local, state, and international levels.
About Georgia State University Center for Leadership in Disability (CLD)
Georgia State University's Center for Leadership in Disability (CLD) is a University Center for Excellence in Developmental Disabilities Education, Research, and Service (UCEDD) funded by the Administration on Intellectual and Developmental Disabilities. The CLD is located within the Mark Chaffin Center for Healthy Development and the School of Public Health. CLD's mission is to translate research into sustainable community practices that contribute to independent, self-determined, inclusive, and productive lives for people with disabilities and their families. The major activities of CLD include community education and technical assistance to people with developmental disabilities, family members, service providers, educators, and professionals; research on implementation of evidence-based practices and the policies that support them; disseminating information about services, supports, and resources for people with developmental disabilities, their families, professionals, service providers, and families; providing advocacy and leadership training; and designing and delivering educational programs for graduate students and professionals.
About the University of Texas at Arlington School of Social Work (UTA SSW)
The University of Texas at Arlington School of Social Work has been the leader in social work education and research for the North Texas community since 1967. The UTA SSW has over 2,000 students currently enrolled across baccalaureate, master's and doctoral programs, with active external funding from the National Science Foundation, the National Institute on Minority Health and Health Disparities, the US Department of Transportation, and the Health Resources and Services Administration. Key project personnel are drawn from the UTA Research Institute, the College of Liberal Arts and the College of Nursing and Health Innovations. We are also collaborating with an award-winning non-profit service provider, Helping Restore Ability (HRA) that "helps restore ability of individuals with disabilities by assisting them to remain self-sufficient so they may continue to live in their homes, go to school and/or work, and most importantly to maintain their independence and dignity".
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Center for Advanced Communications Policy
GSU Center for Leadership in Disability
The contents of this website were developed under a grant from the National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR grant number 90RE5025-01-00). NIDILRR is a Center within the Administration for Community Living (ACL), Department of Health and Human Services (HHS). The contents of this website do not necessarily represent the policy of NIDILRR, ACL, HHS, and you should not assume endorsement by the Federal Government.
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Vacuum casting is used for materials that cannot be cut from or carved out of an original block of material. After making an initial pattern, a silicone based mold is made based on the pattern. This allows the desired material to be casted (poured into pattern cavity and hardened). This method allows for the prototyping of clear plastics and rubber parts. Normally, a vacuum casted mold is good for approximately 10-15 pieces, Vacuum castings produce prototypes that are precise replicas of the mold that are also dimensionally and texturally accurate, Vacuum Casting and silicone molds are perfect for short run production.


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What a romantic place you see on this high resolution image! It is just fantastic. It is not just a glade with benches there. There are trees around and their leafs are red. The grass is yellow. But the place where the benches stand exactly is green. You can find this "Glade with benches" hi definition picture in these categories: Autumn (69), Trees (87). There is a possibility to crop other popular image sizes by using our suggested cropping tool. The size of this HD "Glade with benches" image is 1920x1200 pixels.


text:
Thrombus-specific theranostic nanocomposite for codelivery of thrombolytic drug, algae-derived anticoagulant and NIR fluorescent contrast agent
Lee Hsin Chang, Er Yuan Chuang, Tsai Mu Cheng, Chi Lin, Chun Ming Shih, Alexander TH Wu, Pei Ru Jheng, Hsin Ying Lu, Chun Che Shih*, Fwu Long Mi
Thrombolysis is a standard treatment for rapidly restoring blood flow. However, the application of urokinase-type plasminogen activator (Uk) in clinical therapy is limited due to its nonspecific distribution and inadequate therapeutic accumulation. Precise thrombus imaging and site-specific drug delivery can enhance the diagnostic and therapeutic efficacy for thrombosis. Accordingly, we developed a P-selectin-specific, photothermal theranostic nanocomposite for thrombus-targeted codelivery of Uk and indocyanine green (ICG, a contrast agent for near-infrared (NIR) fluorescence imaging). We evaluated its capabilities for thrombus imaging and enzyme/hyperthermia combined thrombolytic therapy. Mesoporous silica-coated gold nanorods (Si-AuNRs) were functionalized with an arginine-rich peptide to create an organic template for the adsorption of ICG and fucoidan (Fu), an algae-derived anticoagulant. Uk was loaded into the SiO2 pores of the Si-AuNRs through the formation of a Fu-Uk-ICG complex on the peptide-functionalized template. The Fu-Uk/ICG@SiAu NRs nanocomposite increased the photostability of ICG and improved its targeting/accumulation at blood clot sites with a strong NIR fluorescence intensity for precise thrombus imaging. Furthermore, ICG incorporated into the nanocomposite enhanced the photothermal effect of Si-AuNRs. Fu, as a P-selectin-targeting ligand, enabled the nanocomposite to target a thrombus site where platelets were activated. The nanocomposite enabled a faster release of Uk for rapid clearing of blood clots and a slower release of Fu for longer lasting prevention of thrombosis regeneration. The nanocomposite with multiple functions, including thrombus-targeting drug delivery, photothermal thrombolysis, and NIR fluorescence imaging, is thus an advanced theranostic platform for thrombolytic therapy with reduced hemorrhaging risk and enhanced imaging/thrombolysis efficiency. Statement of significance: Herein, for the first time, a P-selectin specific, photothermal theranostic nanocomposite for thrombus-targeted co-delivery of urokinase and NIR fluorescence contrast agent indocyanine green (ICG) was developed. We evaluated the potential of this theranostic nanocomposite for thrombus imaging and enzyme/hyperthermia combined thrombolytic therapy. The nanocomposite showed multiple functions including thrombus targeting and imaging, and photothermal thrombolysis. Besides, it allowed faster release of the thrombolytic urokinase for rapidly clearing blood clots and slower release of a brown algae-derived anticoagulant fucoidan (also acting as a P-selectin ligand) for prevention of thrombosis regeneration. The nanocomposite is thus a new and advanced theranostic platform for targeted thrombolytic therapy.
Acta Biomaterialia
https://doi.org/10.1016/j.actbio.2021.07.072
Published - 15 10月 2021
10.1016/j.actbio.2021.07.072
深入研究「Thrombus-specific theranostic nanocomposite for codelivery of thrombolytic drug, algae-derived anticoagulant and NIR fluorescent contrast agent」主題。共同形成了獨特的指紋。
Theranostics Engineering & Materials Science 100%
Fibrinolytic Agent Chemical Compounds 84%
Algae Engineering & Materials Science 69%
Nanocomposites Medicine & Life Sciences 68%
Theranostic Nanomedicine Medicine & Life Sciences 67%
Fibrinolytic Agents Medicine & Life Sciences 62%
Anticoagulant Chemical Compounds 62%
Contrast Medium Chemical Compounds 57%
Chang, L. H., Chuang, E. Y., Cheng, T. M., Lin, C., Shih, C. M., Wu, A. TH., Jheng, P. R., Lu, H. Y., Shih, C. C., & Mi, F. L. (2021). Thrombus-specific theranostic nanocomposite for codelivery of thrombolytic drug, algae-derived anticoagulant and NIR fluorescent contrast agent. Acta Biomaterialia, 134, 686-701. https://doi.org/10.1016/j.actbio.2021.07.072
Chang, Lee Hsin ; Chuang, Er Yuan ; Cheng, Tsai Mu 等. / Thrombus-specific theranostic nanocomposite for codelivery of thrombolytic drug, algae-derived anticoagulant and NIR fluorescent contrast agent. 於: Acta Biomaterialia. 2021 ; 卷 134. 頁 686-701.
@article{426ced0f19b9454b8c860466f542286f,
title = "Thrombus-specific theranostic nanocomposite for codelivery of thrombolytic drug, algae-derived anticoagulant and NIR fluorescent contrast agent",
abstract = "Thrombolysis is a standard treatment for rapidly restoring blood flow. However, the application of urokinase-type plasminogen activator (Uk) in clinical therapy is limited due to its nonspecific distribution and inadequate therapeutic accumulation. Precise thrombus imaging and site-specific drug delivery can enhance the diagnostic and therapeutic efficacy for thrombosis. Accordingly, we developed a P-selectin-specific, photothermal theranostic nanocomposite for thrombus-targeted codelivery of Uk and indocyanine green (ICG, a contrast agent for near-infrared (NIR) fluorescence imaging). We evaluated its capabilities for thrombus imaging and enzyme/hyperthermia combined thrombolytic therapy. Mesoporous silica-coated gold nanorods (Si-AuNRs) were functionalized with an arginine-rich peptide to create an organic template for the adsorption of ICG and fucoidan (Fu), an algae-derived anticoagulant. Uk was loaded into the SiO2 pores of the Si-AuNRs through the formation of a Fu-Uk-ICG complex on the peptide-functionalized template. The Fu-Uk/ICG@SiAu NRs nanocomposite increased the photostability of ICG and improved its targeting/accumulation at blood clot sites with a strong NIR fluorescence intensity for precise thrombus imaging. Furthermore, ICG incorporated into the nanocomposite enhanced the photothermal effect of Si-AuNRs. Fu, as a P-selectin-targeting ligand, enabled the nanocomposite to target a thrombus site where platelets were activated. The nanocomposite enabled a faster release of Uk for rapid clearing of blood clots and a slower release of Fu for longer lasting prevention of thrombosis regeneration. The nanocomposite with multiple functions, including thrombus-targeting drug delivery, photothermal thrombolysis, and NIR fluorescence imaging, is thus an advanced theranostic platform for thrombolytic therapy with reduced hemorrhaging risk and enhanced imaging/thrombolysis efficiency. Statement of significance: Herein, for the first time, a P-selectin specific, photothermal theranostic nanocomposite for thrombus-targeted co-delivery of urokinase and NIR fluorescence contrast agent indocyanine green (ICG) was developed. We evaluated the potential of this theranostic nanocomposite for thrombus imaging and enzyme/hyperthermia combined thrombolytic therapy. The nanocomposite showed multiple functions including thrombus targeting and imaging, and photothermal thrombolysis. Besides, it allowed faster release of the thrombolytic urokinase for rapidly clearing blood clots and slower release of a brown algae-derived anticoagulant fucoidan (also acting as a P-selectin ligand) for prevention of thrombosis regeneration. The nanocomposite is thus a new and advanced theranostic platform for targeted thrombolytic therapy.",
keywords = "Fucoidan, Gold nanoparticles, Near-infrared imaging, Photothermal therapy, Targeting delivery, Thrombolysis",
author = "Chang, {Lee Hsin} and Chuang, {Er Yuan} and Cheng, {Tsai Mu} and Chi Lin and Shih, {Chun Ming} and Wu, {Alexander TH} and Jheng, {Pei Ru} and Lu, {Hsin Ying} and Shih, {Chun Che} and Mi, {Fwu Long}",
note = "Publisher Copyright: {\textcopyright} 2021 Acta Materialia Inc.",
doi = "10.1016/j.actbio.2021.07.072",
journal = "Acta Biomaterialia",
Chang, LH, Chuang, EY, Cheng, TM, Lin, C, Shih, CM, Wu, ATH, Jheng, PR, Lu, HY, Shih, CC & Mi, FL 2021, 'Thrombus-specific theranostic nanocomposite for codelivery of thrombolytic drug, algae-derived anticoagulant and NIR fluorescent contrast agent', Acta Biomaterialia, 卷 134, 頁 686-701. https://doi.org/10.1016/j.actbio.2021.07.072
Thrombus-specific theranostic nanocomposite for codelivery of thrombolytic drug, algae-derived anticoagulant and NIR fluorescent contrast agent. / Chang, Lee Hsin; Chuang, Er Yuan; Cheng, Tsai Mu 等.
於: Acta Biomaterialia, 卷 134, 15.10.2021, p. 686-701.
T1 - Thrombus-specific theranostic nanocomposite for codelivery of thrombolytic drug, algae-derived anticoagulant and NIR fluorescent contrast agent
AU - Chang, Lee Hsin
AU - Chuang, Er Yuan
AU - Cheng, Tsai Mu
AU - Lin, Chi
AU - Shih, Chun Ming
AU - Wu, Alexander TH
AU - Jheng, Pei Ru
AU - Lu, Hsin Ying
AU - Shih, Chun Che
AU - Mi, Fwu Long
N1 - Publisher Copyright: © 2021 Acta Materialia Inc.
N2 - Thrombolysis is a standard treatment for rapidly restoring blood flow. However, the application of urokinase-type plasminogen activator (Uk) in clinical therapy is limited due to its nonspecific distribution and inadequate therapeutic accumulation. Precise thrombus imaging and site-specific drug delivery can enhance the diagnostic and therapeutic efficacy for thrombosis. Accordingly, we developed a P-selectin-specific, photothermal theranostic nanocomposite for thrombus-targeted codelivery of Uk and indocyanine green (ICG, a contrast agent for near-infrared (NIR) fluorescence imaging). We evaluated its capabilities for thrombus imaging and enzyme/hyperthermia combined thrombolytic therapy. Mesoporous silica-coated gold nanorods (Si-AuNRs) were functionalized with an arginine-rich peptide to create an organic template for the adsorption of ICG and fucoidan (Fu), an algae-derived anticoagulant. Uk was loaded into the SiO2 pores of the Si-AuNRs through the formation of a Fu-Uk-ICG complex on the peptide-functionalized template. The Fu-Uk/ICG@SiAu NRs nanocomposite increased the photostability of ICG and improved its targeting/accumulation at blood clot sites with a strong NIR fluorescence intensity for precise thrombus imaging. Furthermore, ICG incorporated into the nanocomposite enhanced the photothermal effect of Si-AuNRs. Fu, as a P-selectin-targeting ligand, enabled the nanocomposite to target a thrombus site where platelets were activated. The nanocomposite enabled a faster release of Uk for rapid clearing of blood clots and a slower release of Fu for longer lasting prevention of thrombosis regeneration. The nanocomposite with multiple functions, including thrombus-targeting drug delivery, photothermal thrombolysis, and NIR fluorescence imaging, is thus an advanced theranostic platform for thrombolytic therapy with reduced hemorrhaging risk and enhanced imaging/thrombolysis efficiency. Statement of significance: Herein, for the first time, a P-selectin specific, photothermal theranostic nanocomposite for thrombus-targeted co-delivery of urokinase and NIR fluorescence contrast agent indocyanine green (ICG) was developed. We evaluated the potential of this theranostic nanocomposite for thrombus imaging and enzyme/hyperthermia combined thrombolytic therapy. The nanocomposite showed multiple functions including thrombus targeting and imaging, and photothermal thrombolysis. Besides, it allowed faster release of the thrombolytic urokinase for rapidly clearing blood clots and slower release of a brown algae-derived anticoagulant fucoidan (also acting as a P-selectin ligand) for prevention of thrombosis regeneration. The nanocomposite is thus a new and advanced theranostic platform for targeted thrombolytic therapy.
AB - Thrombolysis is a standard treatment for rapidly restoring blood flow. However, the application of urokinase-type plasminogen activator (Uk) in clinical therapy is limited due to its nonspecific distribution and inadequate therapeutic accumulation. Precise thrombus imaging and site-specific drug delivery can enhance the diagnostic and therapeutic efficacy for thrombosis. Accordingly, we developed a P-selectin-specific, photothermal theranostic nanocomposite for thrombus-targeted codelivery of Uk and indocyanine green (ICG, a contrast agent for near-infrared (NIR) fluorescence imaging). We evaluated its capabilities for thrombus imaging and enzyme/hyperthermia combined thrombolytic therapy. Mesoporous silica-coated gold nanorods (Si-AuNRs) were functionalized with an arginine-rich peptide to create an organic template for the adsorption of ICG and fucoidan (Fu), an algae-derived anticoagulant. Uk was loaded into the SiO2 pores of the Si-AuNRs through the formation of a Fu-Uk-ICG complex on the peptide-functionalized template. The Fu-Uk/ICG@SiAu NRs nanocomposite increased the photostability of ICG and improved its targeting/accumulation at blood clot sites with a strong NIR fluorescence intensity for precise thrombus imaging. Furthermore, ICG incorporated into the nanocomposite enhanced the photothermal effect of Si-AuNRs. Fu, as a P-selectin-targeting ligand, enabled the nanocomposite to target a thrombus site where platelets were activated. The nanocomposite enabled a faster release of Uk for rapid clearing of blood clots and a slower release of Fu for longer lasting prevention of thrombosis regeneration. The nanocomposite with multiple functions, including thrombus-targeting drug delivery, photothermal thrombolysis, and NIR fluorescence imaging, is thus an advanced theranostic platform for thrombolytic therapy with reduced hemorrhaging risk and enhanced imaging/thrombolysis efficiency. Statement of significance: Herein, for the first time, a P-selectin specific, photothermal theranostic nanocomposite for thrombus-targeted co-delivery of urokinase and NIR fluorescence contrast agent indocyanine green (ICG) was developed. We evaluated the potential of this theranostic nanocomposite for thrombus imaging and enzyme/hyperthermia combined thrombolytic therapy. The nanocomposite showed multiple functions including thrombus targeting and imaging, and photothermal thrombolysis. Besides, it allowed faster release of the thrombolytic urokinase for rapidly clearing blood clots and slower release of a brown algae-derived anticoagulant fucoidan (also acting as a P-selectin ligand) for prevention of thrombosis regeneration. The nanocomposite is thus a new and advanced theranostic platform for targeted thrombolytic therapy.
KW - Fucoidan
KW - Near-infrared imaging
KW - Photothermal therapy
KW - Targeting delivery
KW - Thrombolysis
U2 - 10.1016/j.actbio.2021.07.072
DO - 10.1016/j.actbio.2021.07.072
JO - Acta Biomaterialia
JF - Acta Biomaterialia
Chang LH, Chuang EY, Cheng TM, Lin C, Shih CM, Wu ATH 等. Thrombus-specific theranostic nanocomposite for codelivery of thrombolytic drug, algae-derived anticoagulant and NIR fluorescent contrast agent. Acta Biomaterialia. 2021 10月 15;134:686-701. doi: 10.1016/j.actbio.2021.07.072


Most of the body art end up healing perfectly, but sometimes problem might appear during the healing process. Tattoo scar is one of them. In this post, we will discuss about tattoo scars, and in addition to that, you will also come to know how you can deal with them.
The process of tattooing is an overwhelming journey. First of all, you have to choose the best design and the body part for your tattoo. In addition to that, you also have to choose the best tattoo studio in Melbourne to get the job done. After the tattooing process you have to focus on its aftercare. If you don't pay enough attention to your aftercare, then you might end up developing tattoo scars. In fact, studies have also revealed that one might also create a scar during the tattooing process. The tattoo removal process might also cause you scars.
In this section of the post, you will learn about the symptoms of tattoo scars. Here comes the question what you can do to treat the symptoms. So continue reading to know about the treatment of tattoo scars.
Scar Ointment: If you search carefully in the market then you will find scar-fading ointment like Mederma, Bio Oil etc. By using them, you will be able to diminish your scars.
Aloe Vera: This is an excellent thing which is known for its skin-healing properties. Aloe Vera gel is highly beneficial for wounds like burns. You can also apply this product on tattoo scars and get rid of it.
These are the things that you need to apply on your scars to treat it. Meanwhile, you also have to focus on completing the tattooing process successfully. You need to hire the best artist to complete the tattooing process. By performing a Google search, you will easily find the top tattoo artists in Melbourne. According to your preference, you can hire any of them to get the job done. This is all for now. Hope it will help you to fight against tattoo scars.


Foreign Missions Center, Walter Reed Army Medical Center, western portion bound by 16th Street, Alaska Avenue, Fern Street, and Main Drive, NW. Master plan. Concept.
Southwest Waterfront Development ("The Wharf"), Public spaces, amenities, and landscapes associated with Parcels 1, 2, 3b, 4, and 5, District Pier, Transit Pier, Market Pier, 7th Street Park, the Mews, Yacht Club Plaza, and Maine Avenue, SW. Concept.
Southwest Waterfront Development ("The Wharf"), Water Street and M Place, SW. Waterfront Park. Concept.
Museum of the Bible (Passages), 300 D Street, SW. Additions, alterations, and rehabilitation of Washington Design Center Building and adjacent office building. Revised concept.
Georgetown University – new residence hall, 3700 O Street, NW. New eight-story building. Concept.
DC KIPP College Prep High School (formerly Hamilton Special Education School), 1401 Brentwood Parkway, NE. New school building. Concept.
Duke Ellington School of the Arts, 1680 35th Street, NW. Building modernization and additions. Revised concept.
Congressional Gold Medal honoring the First Special Service Force Designs for a gold medal with bronze duplicates. Final.
United States Marshals Service 225th Anniversary Commemorative Coin Program Designs for a five–dollar gold, one–dollar silver, and half–dollar clad coin. Final.
2015 and 2016 Presidential One Dollar Coin Programs Obverse designs for the ninth and tenth sets of coins. Final.
2015 and 2016 Native American One Dollar Coins Reverse designs for the seventh and eighth sets of coins. Final.


We'd love to keep you updated with the latest Blatchford news, let you know when we launch new products and services, and share some of the amazing stories from people using our life changing products. We'll only use the information you supply here for this purpose and we'll never pass your details on to anyone else.
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For news and updates on Blatchford products and services for private patients provided through our private clinics, including medical-legal.


text:
Q: Insert a modal razor page in the navbar. How to do it? I'm building a new website and one of the requirements is to have the login form be a modal window. I'm trying to include it in the top navigation bar and it's only being rendered if the user is not logged in.
How can I add this modal window with it's own model inside the top navbar? Are there any alternatives?
If I delete the model and let an empty modal everything works perfectly but when I add it again it doesn't work, because the model of the page (in this case the index page) is a different one then the one from the modal login.
P.S. I'm using Razor Pages and ASP.NET Core 2.2.

A: Partial View
So you make a _LoginPartial.cshtml file. and let's say you set @model LoginViewModel
Inside this _LoginPartial.cshtml you have your Login Modal and all the functionality.
Now when you invoke your partial inside an Index page that has model @model AnotherModel, you need to pass a new model to the partial like so:
<partial name="_LoginPartial" model='new LoginViewModel()' />
name is the name of your cshtml page.
model is the @model of the page.
Read More Here
View Components
To be brief if you take this route this is essentially like nesting a little controller inside your page. Allowing you to change scope for your @model.
Read more about View Components
Update for nested objects
You need to instantiate the object property.
<partial name="_LoginPartial"
           model='new LoginViewModel { InputModel = new InputModel() }' />


text:
BlackBerry diversifies into autonomous cars with Ford deal
admin Digital Cars 122,081
BLACKBERRY announced a partnership with carmaker Ford to develop automotive software solutions that hint at a self-driving future, as it continues a "pivot from hardware to software" and moves beyond the smartphone business.
BlackBerry's QNX software already powers Ford's SYNC 3 Infotainment system and is found in 60 million cars from other carmakers.
In a statement, BlackBerry said the deal will see Ford expand the use of its QNX and security software "in developing the next generation of connected cars", but reportedly bought through Panasonic.
In a blog by John Wall, Senior Vice-President and Head of QNX Software Systems at BlackBerry, Wall wrote: "QNX may be best known as a platform for infotainment and 3D navigation. But underlying what you see on your car's dashboard are the fundamental building blocks for the modules in cars that can control an automobile. In fact, our ADAS platform is the only one available today that is ASIL-D certified, meaning it is the only one ready today for carmakers to create autonomous car driving systems on top of it."
BlackBerry added that it will dedicate a team to work with Ford on expanding use of the system, but said that the terms of the deal with Ford are confidential.
After deciding to axe its struggling smartphone business in September, BlackBerry is pinning high hopes on the automotive sector, and said the deal with Ford extends its position in providing security and mobility solutions, that "are critical for the connected car".
Nissan Note to debut e-Power hybrid drivetrain The age of virtual reality (VR)
Ford, Toyota forge in-car app...
Nissan aims to roll-out autonomous cars...
Nissan Note to debut e-Power hybrid...


Looking great, while spending less for men's dress pants seems like a smart buyer's point of view. Cut from a wrinkle resistant and stain resistant lightweight fabric, you will save money and time on maintenance as this garment is machine washable.
This budget priced style is a classic pleated front that is designed for maximum comfort, as the woven cloth wicks odor and perspiration. A perfect selection for part of a work uniform, there are two front and two back pockets. The zipper has been upgraded to brass, while the waist closes with a hook/eye.
Choice of two colors and waist sizes from 28 to 54 inches, inseams can be shipped unhemmed or hemmed from 28 to 36 inches, big men's and tall men's sizes are covered. Let our online size chart help you get the best fit. Bulk Pricing.


text: Q: Near-Near-MDS codes I am trying to understand the codes which are not maximum distance separable but are at a distance of 2 from being Maximum Distance Separable. I have trying to find articles specifically related to the topic and trying to find an example of it too. But have been unable to do so. Can someone please guide me as to what material should I refer to or if someone can give an example of generator matrix of space of codewords which ar at a distance 2 from being MDS, that is near-near MDS codes?


We once opined that we were hard pressed to find great casual French restaurants in San Francisco. Now Monsieur Benjamin, opened last July by Co-Owners/Executive Chefs Corey Lee and Jason Berthold, is definitely filling the void. Both chefs are heavily pedigreed, with Lee having spent several years earning Michelin stars as Executive Chef at the French Laundry under Thomas Keller before striking out on his own with the excellent Asian-inspired Benu. Berthold was the opening chef for Michael Mina's RN74 and stayed there for almost four years before joining forces with Lee to open Monsieur Benjamin.
Both chefs are extremely well versed in French cooking techniques, so it was with high anticipation that we dined at Monsieur Benjamin, their more casual (albeit still classy) bistro-style restaurant. Whimsically named by Chef Lee after he heard the name called out by a bellman in a Paris hotel, Monsieur Benjamin struck him as a perfect moniker that is both very French and very American. It's an apt name for the restaurant since the menu evokes classic French fare while keeping San Francisco sensibilities.
The ambitious 50-item bistro menu is divided into six primary categories: Fruits de Mer (chilled seafood), Petit Plats (small plates), Hors d'Oevres (appetizers), Plats de Resistance (main course), Garnitures (sides) and Fromage et Desserts (cheeses and desserts). Over a couple of visits, we tried to sample as much of the menu as we could but still haven't made our way completely through.
We're definitely looking forward to making our way through the rest of the menu. The chilled seafood platter is a new item that we are definitely looking forward to ordering.


text:
Canadian stamp marks centennial of insulin discovery
Apr 15, 2021, 2 PM
Canada Post issued a stamp April 15 to honor the 100th anniversary of the discovery of insulin by Frederick Banting, Charles Best, James Collip and John Macleod. The stamp shows an early insulin vial and an excerpt from an unpublished memoir by Banting.
A 1971 6¢ stamp commemorates the 50th anniversary of the discovery of insulin and shows lab equipment used in that medical breakthrough.
Dr. Frederick Banting was honored for his role in discovering insulin on Canadian stamps issued in 1991 and 2000. The former stamp is part of a set featuring physicians, and the latter is part of Canada Post's Millennium series.
By Denise McCarty
Canada Post commemorates the 100th anniversary of the discovery of insulin on a nondenominated permanent-rate (currently 92¢) stamp issued April 15.
In Details, Canada Post's magazine for collectors, Jim Phillips, the director of stamp services, said: "The centennial of one of Canada's most important medical discoveries is celebrated for the life-changing impact it has had on people with diabetes around the world."
The new stamp shows a vial of insulin and an excerpt of an unpublished memoir by Dr. Frederick Banting (1891-1941). Canada Post said that the excerpt "reflects the very moment he conceived the idea that set in motion events leading to the discovery of insulin."
That discovery in 1921 at the University of Toronto and the first successful use of insulin in a human in early 1922 at Toronto General Hospital was a team effort with "surgical approach of Dr. Banting, the critical input of research assistant Charles Best and visiting biochemist James Collip, and the advice, guidance and oversight of John Macleod, chair of the Physiology Department" according to Canada Post.
Banting and Macleod received the 1923 Nobel Prize in physiology or medicine for the discovery. Banting shared his award money with Best, and Macleod shared his with Collip.
The website of the Nobel Prize summed up the work that led to the prize: "Diabetes is the body's inability to metabolize sugar correctly. Doctors realized that diabetes is caused by a lack of insulin, which is formed in parts of the pancreas, but could not prove it. Frederick Banting suspected that another substance formed in the pancreas, trypsin, broke down the insulin. In John Mac-Leod's laboratory in 1921, Frederick Banting and Charles Best treated dogs so that they no longer produced trypsin. Insulin could then be extracted and used to treat diabetes."
The first person to receive insulin injections was 14-year-old Leonard Thompson (1908-35) in January 1922. Thompson weighed only 65 pounds and was in critical condition. At the time, people with Type 1 diabetes (formerly called juvenile diabetes) were only expected to live a few years at most, and the treatment used to extend their lives was a starvation diet.
Canada Post said: "Although Leonard had an adverse reaction to the initial formula, a second round of injections — administered after further refinements — saved his life. From these early trials came the medical breakthrough now known as insulin. The diagnosis of diabetes was no longer considered a death sentence."
Previous Canadian stamps commemorate Banting and the discovery of insulin.
The first, a 6¢ stamp issued May 3, 1971, marked the 50th anniversary of the discovery (Scott 533). The design shows laboratory equipment used in the discovery.
Banting was honored on a 40¢ stamp in the 1991 Physicians issue (Scott 1304) and on a 46¢ stamp (1822) in the Medical Innovators set issued Jan. 17, 2000, as part of Canada Post's Millennium series.
The 1991 stamp shows a portrait of Banting in the foreground with a University of Toronto medical building in the background. The stamp in Canada Post's Millennium series includes images of Banting, Best, a dog and a hypodermic needle in the foreground and handwritten notes in the background.
The new Insulin stamp was designed by Subplot Design of Vancouver, British Columbia, using images of the insulin vial courtesy of Sanofi Pasteur Canada (Connaught Campus) archives, and Banting's notes courtesy of the Banting Collection, Thomas Fisher Rare Book Library, University of Toronto. Seth Stevenson took the photos, according to Canada Post.
The stamp is 40 millimeters by 25mm. Lowe-Martin printed it by six-color lithography in booklets of 10. A total of 130,000 booklets (1.3 million stamps) were printed.
Canada Post created 7,000 first-day covers canceled in Toronto, Ontario. The overall cachet shows covers that contained letters of gratitude sent to Banting, including one simply addressed "to the Dr. who cures diabetes, Toronto, Ont."
The new Insulin stamp (ordering no. 414164111) and FDC (414164131) are available from Canada Post, and by mail order from Canada Post Customer Service, Box 90022, 2701 Riverside Drive, Ottawa, ON K1V 1J8 Canada; or by telephone from the United States or Canada at 800-565-4362, and from other countries at 902-863-6550.
They also are available from many new-issue stamp dealers, and from Canada Post's agent in the United States: Interpost, Box 400, Hewlett, NY 11557.
Canada Post to issue Eid stamp April 22
Apr 8, 2021, 2 PM
Canada Post honors its music awards, the Junos
Mar 2, 2021, 10 AM
Canada's new Flower stamps are a sign of spring


Is it worth upgrading to 7.1 surround sound?
Most all-in-one surround sound systems will be either 5.1 or 2.1. It isn't normally until you go the separate amplifier and speakers route that you're likely to even have the option of a full 7.1 system.
Whilst the temptation to chuck another couple of speakers into your set up is hard to resist, there are a couple of questions to consider first.
Can you fit in another two speakers?
Generally, a 7.1 system suits a larger listening room. This is because the positioning of the four rear speakers is crucial to getting the benefits. You will need to position two of the speakers behind the listening position, and the other two to the side of the listening position. If you have your sofa slammed against the back wall of your room for example, this is going to be difficult to achieve. But if you can successfully site the speakers, 7.1 becomes an option.
Is 7.1 Surround Sound Worth It?
This is the second factor, and the old adage "Quality is better than quantity" comes in here. More speakers do not necessarily mean better sound! For example, you may need to decide if you would be better off spending the money on upgrading your existing rear speakers if you feel there is room for improvement. Otherwise given the right room environment, 7.1 can make the sound feel more immersive.
If you have decided to go the 7.1 route, you need to get yourself an additional two speakers. We are big believers that the speakers should match each other in quality and sound as closely as possible. This especially important in the front speakers where you want a coherent and seamless sweep of sound. Whilst it is not as crucial that the rear two speakers match the fronts, if you add an additional two speakers to the rear, it is important that all the rears match each other as closely as possible, otherwise you run the danger of not getting any benefit from your 7.1 system. The whole principle is that the sound is immersive, and that means all the speakers need to be similar, if not identical, otherwise you will be able to notice the difference in quality and sound as the effects sweeps around.
Stick with 5.1 and Bi-amp?
Many people reading this will have an amplifier capable of bi-amping (not to be confused with bi-wiring) such as the Onkyo 607. If you also have speakers with four input terminals you have the option of sticking with 5.1 or and using the spare two channels to bi-amp the front speakers i.e. power the high and low frequency inputs of the speakers separately. It is quite simple to achieve and will only require an additional two runs of speaker cable from the amp to your front speakers, removing the bridging plate on the speaker input terminals and changing a setting on the amp. It should give a noticeable improvement, with a more open sound as the high and low frequency signals get a better quality and dedicated supply.
Overall, if you can fit in the additional speakers, and your money would not be better off being spent on another part of your system, then 7.1 surround sound will definitely enhance the immersive home movie experience.


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Air Force to develop F-16 'digital twin'
The U.S. Air Force plans to make a digital replica of the F-16 Fighting Falcon, in an effort to improve the sustainment and modernization of F-16s operating around the world.
309th Aerospace Maintenance and Regeneration Group returns final T-1A to training operations
A fleet of hail-damaged T-1A "Jayhawk" trainers are now back in the air thanks to a unique repair and maintenance mission performed by the 309th Aerospace Maintenance and Regeneration Group at Davis-Monthan Air Force Base, Ariz.
First KC-10 arrives at 309th Aerospace Maintenance and Regeneration Group
Approximately 40 years after the KC-10 Extender took to the skies for the first time, a KC-10 from the 305th Air Mobility Wing at Joint Base McGuire-Dix-Lakehurst, New Jersey, was retired and arrived at the 309th Aerospace Maintenance and Regeneration Group July 13 for storage.
A QueSST for speed and parts: 309th AMARG's role in quiet supersonic technology development
Recall when traveling faster than the speed of sound was possible aboard the supersonic airliner called the Concorde, flying 3,459 miles from New York to London in around three hours. Those days might not be gone forever if NASA, Lockheed Martin and the 309th Aerospace Maintenance and Regeneration
Bye-bye 'Wise Guy'
A team of Air Force maintainers spent four months prepping Wise Guy, a B-52 Stratofortress for flight. The bomber had been in storage at the 309th Aerospace Maintenance and Regeneration Group since 2008.
Sustaining the Ogden ALC, F-16 relationship
Though Hill's operational F-16s have departed, the Ogden Air Logistics Complex continues to sustain and fly one of the world's most widely recognized and widely used fighter aircraft ever to take to the skies, with ongoing regeneration, depot-level maintenance and modifications on C and D model
Final C-27J departs 309th AMARG for the U.S. Coast Guard
After a successful collaboration between the 309th Aerospace Maintenance and Regeneration Group and the U.S. Coast Guard, the last of 13 regenerated C-27J Spartans returned to service October 19. When the U.S. Air Force retired the twin-engine, light cargo aircraft in 2013, the Coast Guard expressed
309th AMARG sends off final regenerated C-27J
A C-27J Spartan prepares to depart from Davis-Monthan Air Force Base, Oct. 19, 2017. This aircraft was the last of 13 C-27Js which were regenerated from the 309th Aerospace Maintenance and Regeneration Group at D-M and given to the U.S. Coast Guard. (U.S. Air Force photo by Airman 1st Class Frankie
309th AMARG delivers 23 F/A-18C Hornets ahead of schedule
Tucson's 309th Aerospace Maintenance and Regeneration Group, commonly referred to as AMARG, recently completed a project to withdraw 23 F/A-18C "Hornet" jet fighters from war-reserve storage and deliver them to the U.S. Marine Corps for return to flying service. The 309th AMARG is part of the Ogden


Grant, almighty God, that we may celebrate with heartfelt devotion these days of joy, which we keep in honour of the risen Lord, and that what we relive in remembrance we may always hold to in what we do.
Proclaim a joyful sound and let it be heard; proclaim to the ends of the earth: the Lord has freed his people, alleluia.
I shall ask the Father, and he will give you another Advocate to be with you forever, that Spirit of truth.
A time of transition: Jesus prepares his friends for his departing and the Spirit's coming. They and the early Church begin to understand this new (unseen) presence of Jesus.
How are they to respond? I may like to reflect on the 'comings' and 'goings' of my life.
'I will not leave you orphans…' I may ask to feel the depth of Jesus' love for his disciples – for me.
The word 'Advocate' can mean one who comforts – and even more than this: one who gives power and courage to help me cope calmly with life.
I may feel moved to pray for an even deeper understanding of the effects of the Spirit of Jesus in me: to be a person of deeper faith; to make wise decisions; to be open-minded and accepting of others, and so on.
How am I moved to end my prayer?


Video Insight stores all camera-related settings in a Microsoft SQL Server database. In multi-server configurations, a single database can be used to store all settings.
Video Insight uses a Microsoft SQL Server database to store system settings, user permissions, activity, alarm, and system logs.
Video Insight supports distributed and centralized deployments. With increases in bandwidth, switching, and better compression, it's now possible to move the servers to a central data centre.
The Video Insight Server supports Automated Failover at no additional software cost. When utilizing the Video Insight Single Database configuration, a physical or virtual server can be designated as a Failover.
Video Insight IP Server runs as a Windows Service on 32 or 64 bit OS. Requesting images from the cameras, the IP Server processes the images for motion alarm, stores the video in a folder structure, and saves all configuration, motion, and system logs in a SQL server database. The Clients connect to the IP Server - not directly to the cameras - and the Web Client uses Microsoft Internet Information Server (IIS). From an architecture perspective, Video Insight has four components: Server; Storage; SQL and IIS - each of which can be configured a number of ways to adapt to your organization's needs.