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Stephen King Finally Addresses Controversial 'IT' Child Orgy Scene That Was Cut From the Movie
"There has been so much comment about that single sex scene and so little about the multiple child murders."
Thomas Freeman
As Stephen King's IT returns to the zeitgeist, with the reboot film's record-breaking opening weekend, an old controversy has also resurfaced.
Numerous cultural pundits have dug up that controversial child orgy scene from the 1986 source novel, when Beverly invites the rest of the Loser's Club to have sex with her just before their climactic showdown with Pennywise.
It's an odd means of uplifting group morale that was axed from the 1990 TV miniseries as well as Andy Muschietti's 2017 blockbuster reimagining.
Vulture tracked down a 2013 quote purporting to be from Stephen King, which explains why he wrote it without necessarily defending it.
I wasn't really thinking of the sexual aspect of it. The book dealt with childhood and adulthood –1958 and Grown Ups. The grown ups don't remember their childhood. None of us remember what we did as children–we think we do, but we don't remember it as it really happened. Intuitively, the Losers knew they had to be together again. The sexual act connected childhood and adulthood. It's another version of the glass tunnel that connects the children's library and the adult library. Times have changed since I wrote that scene and there is now more sensitivity to those issues.
(Photo: Warner Bros.)
Vulture reached out to King to confirm the quote is his, and he responded, "That sounds like my statement."
"To it I'd just add that it's fascinating to me that there has been so much comment about that single sex scene and so little about the multiple child murders. That must mean something, but I'm not sure what."
Like poor Georgie's arm being BITTEN OFF (spoiler), which has seen little controversy outside of one op-ed from Fast Company.
https://www.youtube.com/watch?v=HMmPHiMuMIM
Well played, King.
Tags: Books Controversy It movies Novels Stephen King
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Advocates Call On New York Legislature To Extend Invasive Species Law
Pat Bradley/WAMC
Invasive steward sign
A New York law that prohibits watercraft from launching into waters without taking precautions to prevent the spread of invasive species is set to expire at the end of the month. Adirondack advocates are urging the state legislature to renew and expand the provision.
A section of New York Environmental Conservation Law pertaining to invasive species states that no one "..shall launch a watercraft or floating dock unless it can be demonstrated that reasonable precautions such as the removal of any visible plant or animal matter, washing, draining or drying…have been taken." The law was passed five years ago with a sunset provision effective June 1st unless the legislature takes action.
Adirondack Park Invasive Plant Program Director Brendan Quirion says it's the only regulation that has provided teeth to the clean-drain-dry approach being used to prevent the spread of invasive species. "With this regulation boaters are required to take that reasonable precaution. What that really means is that they need to be practicing clean-drain-dry before they launch into any New York water body. If they follow that approach the likelihood for introducing or spreading invasive species is very slim and that's why it's so important. What we've found with this particular regulation is there has really been no conflict with users. People are very compliant with the regulation and want to do the right thing in practicing clean-drain-dry. So the sunset clause was for the end of May so now is the point where we need to ensure that it's continued, extended and ideally made permanent so that this would never happen again."
The Adirondack Council has found that the law made a difference in awareness and in limiting the spread of invasives. Spokesman John Sheehan says the group wants the provision renewed and made permanent. "We think that this would have a big impact on stemming the tide of invasive species into the Adirondack Park's waters. We are very lucky that because of our isolation from other more busy parts of the state a lot of the Park's interior waters do not have invasive species in them at all at the moment and some that have been infested have only one or two that are affecting the ecosystem but haven't caused dramatic change quite yet. So we are in a position where we can keep the Park from being significantly affected by this but we have to take action now. It's something that's necessary for the Park's continued health."
Both groups are lobbying the state legislature to extend the law and the Adirondack Council would also like a new provision requiring all boats be decontaminated before entering any Adirondack waters. But Quirion doesn't think there's time to add such a provision before the session ends in mid-June. "Ideally we would want to see it made permanent but at the very least I'd like to see it extended for at least five years. At this point I'm pretty optimistic as far as it being extended. If we were to push for anything above and beyond that, whether it be for more stringent standards like mandatory boat inspection decontamination or potentially making it permanent, that might require more time. But I am optimistic that it will be at least extended."
Loon Lake and Lake George are the only places in the Adirondacks that mandate inspections before putting boats or other craft into the water.
North Country NewsInvasive SpeciesInvasivesBoat InspectionsClean Drain DryAdirondack Invasives
Commission OK's Mandatory Boat Inspections for Upstate Lake
The Lake George Park Commission has approved a mandatory boat-washing and inspection program to protect one of New York's most popular lakes from invasive…

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Preste atenção antes de reservar.
Harbour Beach Villas is about a two minute walk to the beach. However, each one of our villas has an amazing view of Secret Harbour because they are nestled in the hillside.
Yes, you can find fishing charters at the nearby dive shop or you can visit Red Hook which is a five minute drive away for more options. Our General Manager is always happy to give you personal suggestions.
Is there a washer/dryer in each unit?
There are no laundry facilities in the units. For extended stays, arrangements can be made with our General Manager for some laundry services.
How far from airport to the villa? Take a cab? Do they have transportation?
Harbour Beach Villas is about an hour away from the airport. Taxis are readily available once you land and will be able to get you here quickly.


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Q: vb.net webbrowser control, does not refresh htmltext I have googled far and wide to the ends of china and the tip of south america... I cant seem to find a concrete solution to this common problem.
I am developing a google maps ap, and want to refresh the map with new detail on demand. The initial problem offcourse was that the webbrowser control does not reflect the changes (still keeps the original htmltext) and new document text and refresh. I understand the document text is set once, and cant be changed... apparently.
I have tried
navigate("about:blank")
document.stop
document.new(true)
doevents

All the collected user knowledge on this problem, only get me half way. I can get the page refreshed using some of the techniques above, but it then gives me a script error and an error 53, which both has no details or origins.. just blank errors.... after clicking through their error windows, my page refreshes.
Can anyone shed some light on a clear cut solution. Can it really be this big of an issue?
P.S. I don't know if my javascript events that are bound to the webbrowser control causes the errors. Some have suggested that the errors are due to the document loading without all its references being closed/open...
Can someone please save me from insanity.

A: Louis, how are you mate? I understand how WB control issues can be deal breakers, I will help you out until we solve this issue. However, could you tell me more about the HTMLText and DocumentText and what you mean by them? are they properties of the WB control? I'm using a pre-.NET WB control, it is still mainly the same thing but the .NET one has a few more fancy properties & methods :).
Ok, first thing is first, are you SURE this new data exchange isn't happening inside a frame or an iframe? Hence, you are not able to see any change in the HTML text of the top-level html document/page? I have a function which recursively grabs references to all the frames on the page, and all the frames in those frames, being every single frame and all nested frames up to infinite-depth. That might be able to help you.
Also, what are you using to get the text? The html document is a LIVE document, in that, as elements change, the DOM changes, and what you read from the DOM will also be updated, it is a 100% live document, and as long as you are declaring your document as a MSHTML.IHTMLDocument then you should be good to go.
Most importantly, I didn't hear you mention .innerText, .outerText, .innerHTML and .outerHTML. These are of course the items you want to be retreiving text/source from. If you want the full pages, check those properties out! So, if you want the Text inside the BODY tags, you would do the following:
Say, out IHTMLDocument object is called hDoc.
MsgBox hDoc.body.innerText

That will show you only the text inside the BODY tags, to get the HTML inside the BODY tags, just do this.
MsgBox hDoc.body.innerHTML

Now, if you want the HTML in the BODY tags while also retreiving the starting and closing BODY tags, then you'd do this:
MsgBox hDoc.body.outerHTML

... etc...
Of course, if you want to refresh the document for whatever reason, there is a refresh method of the webbrowser control, it's WebBrowser1.Refresh and I think there is a .Refresh2 which has slightly different refresh logic.
I can go on and on, but would like to know I've understood your question correctly before we do. Now, the only thing that changes is the live Image of the map inside the webbrowser control, doesn't it? Perhaps some text around it as well like address/etc? Or is it just the image data that changes (been a while since I used google maps, and not sure which implementation you are using), so if you could let me know what exactly changes and what you are trying to pick up/read, I should be able to help you better, all in all, I promise to hold your hand until we figure this thing out (lol) - cheers mate, let me know how it goes.
Erx.

redpajama_set_name: RedPajamaStackExchange


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The Art and Science of Dealing with Difficult People
David Brown (?):
The Art and Science of Dealing with Difficult People (?)
David Brown, Books, Business and Finance, Human Resources and Personnel Management, Organizational Behavior, The Art and Science of Dealing with Difficult People, In The Art and Science of Dealing with Difficult People, David Brown pinpoints the seven principles of relationship building that are crucial to creating a successful working environment. Brown breaks down each principle by providing easy to understand instructions and universally applicable management skills.Brown's philosophy is to approach work place discord as a problem from both a managerial and lower level perspective. He offers advice on how to treat employees, while at the same time asking leaders to reflect and make self-adjustments which will facilitate a more efficient work space. Readers will gain a deeper understanding of how their employees view management personnel, what leadership skills are most effective, and how to ensure two-way communication. Using Brown's tried and true tools, anyone can learn to focus on how to motivate, establish trust, and form a psychological contract.Numerous case studies throughout allow readers to observe the concrete application of Brown's suggestions in real-life scenarios and complex situations, such as mergers and staff integration, information management, and more. In addition, The Art and Science of Dealing with Difficult People provides readers with skills drawn from an understanding of the basic fundamentals of human behavior.
Category: Books>Business and Finance>Human Resources and Personnel Management>Organizational Behavior
business,business and investing,human resources and personnel management,industries and professions,management,management and leadership,psychology, In The Art and Science of Dealing with Difficult People, David Brown pinpoints the seven principles of relationship building that are crucial to creating a successful working environment. Brown breaks down each principle by providing easy to understand instructions and universally applicable management skills.Brown's philosophy is to approach work place discord as a problem from both a managerial and lower level perspective. He offers advice on how to treat employees, while at the same time asking leaders to reflect and make self-adjustments which will facilitate a more efficient work space. Readers will gain a deeper understanding of how their employees view management personnel, what leadership skills are most effective, and how to ensure two-way communication. Using Brown's tried and true tools, anyone can learn to focus on how to motivate, establish trust, and form a psychological contract.Numerous case studies throughout allow readers to observe the concrete application of Brown's suggestions in real-life scenarios and complex situations, such as mergers and staff integration, information management, and more. In addition, The Art and Science of Dealing with Difficult People provides readers with skills drawn from an understanding of the basic fundamentals of human behavior.
Category: Psychology
£ 8.20(free shipping, without obligation)
Provides seven principles for developing stronger relationships and fostering better communication skills in any working environment.
ISBN: 9781616083632 (?) or 1616083638, in english, Skyhorse Publishing, Paperback, New
Art-and-Science-of-Dealing-with-Difficult-People~~David-Brown, The Art and Science of Dealing with Difficult People, paperback
Category: Business>Motivation/Self Management>Motivation/Self Mgt
Brown, David (?):
ISBN: 9781616083632 (?) or 1616083638, in english, Skyhorse Pub Co Inc, SKHSC, SKHSC, Used
A simple and succinct guide to help leaders in every field master the art of conflict resolution.
Seller order number: 220945165
Platform order number Rakuten.com: 220945165
Category: Books~~Business & Economics~~Organizational Behavior
[More][Watch book][Save book]Details »Order at Rakuten.com »
Available rare books, used books and second hand books of the title "The Art and Science of Dealing with Difficult People" from Brown, David are completely listed.
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(A) Adult Supervision - an adult should always supervise children around water.
(B) Barriers - a self latching/locking gate should be in place to isolate your pool and spa from the home and play yard.
(C) Classes including CPR for adults and swim lessons for children. You are your child's first responder!
Drowning is a leading cause of unintentional injury and death for children 4 years and younger. Floaties and other flotation devices should NEVER be substituted for adult supervision.
Always empty water in buckets, ice chests and bathtubs. A child can drown in as little as two inches of water.


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DethKarz ist ein futuristisches Rennspiel für PC, das 1998 in Deutschland von Infogrames vertrieben wurde. Entwickelt wurde es vom australischen Studio Beam Software. Originaler Vertriebspartner war Melbourne House.

Spielinhalt
Ziel des Spiels ist es, sich auf kniffligen Rennstrecken in vier unterschiedlichen Umgebungen (Stadt, Karibik, Antarktis, Mars) den ersten Platz gegen 19 konkurrierende Fahrer zu erkämpfen. Dabei kann der Spieler seine Konkurrenten auch mit Waffengewalt bekämpfen. Die Strecken weisen häufig frei schwebende Fahrbahnen ohne Seitenbegrenzung auf und zeichnen sich durch schwierige Kombinationen von Kurven und Steigungen aus. Überfährt der Spieler die Fahrbahnbegrenzung und fällt in die Tiefe, so wird er nach kurzer Zeit wieder auf die Fahrbahn teleportiert. Die aktuelle Geschwindigkeit des Fahrzeugs halbiert sich hierbei. Auf den Strecken ist eine Fülle von Powerups verteilt, die das Fahrverhalten des eigenen Boliden kurzzeitig verbessern, bessere Waffen zur Verfügung stellen oder Schutz vor bestimmten Waffen bieten.

Es stehen vier Fahrzeuge zur Auswahl, die sich im Fahrverhalten stark unterscheiden. Fahrzeuge weisen Beschädigungen auf (grafisch jedoch nur durch Rauch), diese haben jedoch keinen Einfluss auf das Fahrverhalten. Übersteigt das Schadensniveau ein bestimmtes Maß, explodiert das jeweilige Fahrzeug und ist aus dem Rennen. Reparaturen erfolgen im Boxenbereich, bei dem die Reparaturen proportional zu Aufenthaltsdauer fortschreiten, bzw. durch ein hellblaues Powerup.

Kernstück des Spiels ist der Meisterschafts-Modus. Bei diesem muss der Spieler ein Minimum an Qualifikationspunkten erreichen, um am Ende als Sieger dazustehen. Auf diese Weise schaltet der Spieler weitere Strecken und Fahrzeug-Upgrades frei. Neben dem Meisterschaftsmodus kann der Spieler ein Einzelrennen starten oder versuchen, im Zeitfahren neue Rundenrekorde aufzustellen.

Ein Mehrspielermodus über Netzwerk existiert und bietet Platz für 8 Rennteilnehmer.

Technik
DethKarz wurde sowohl für die DirectX-Schnittstelle als auch für die Glide-Grafikschnittstelle programmiert.

Kritik
DethKarz konnte bei Kritikern trotz des relativ geringen Spielumfangs dank seiner effektreichen 3D-Grafik und der überzeugenden Fahrphysik punkten und erzielte durchweg gute Wertungen.

Computerspiel 1998
Windows-Spiel
Rennspiel
Science-Fiction-Computerspiel

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HomeNewsmakersFuture of Cheese's (OTC: OGGFF) Plant-Based Brie Launch Is Selling Faster Than Expected
December 8, 2021 admin Newsmakers Comments Off on Future of Cheese's (OTC: OGGFF) Plant-Based Brie Launch Is Selling Faster Than Expected
The Company's distributor has satisfied all initial retailer orders and sells through the first production run of the plant-based brie
TORONTO, December 07, 2021—-Organic Garage Ltd. (TSXV: OG | OTCQX: OGGFF | FRA: 9CW1), one of Canada's leading independent organic grocers, is pleased to announce that its plant-based food company, Future of Cheese Inc. ("Future of Cheese" or the "Company"), has reported a successful launch of the Company's recently announced plant-based brie, selling through its first production run while satisfying all retailer orders. The plant-based brie launched through retailers last week and builds on the recent success of the Company's plant-based butter and rapidly growing brand awareness.
"The retail response is even better than anticipated. Selling out our first production run without incurring lost product costs is as successful as it gets in the CPG business," stated Jen Wojtaszek, President of Future of Cheese. "We are currently increasing production for all of our current products in anticipation of the holiday season, accelerated in part by increased interest from new retailers and potentially high-profile foodservice and restaurant partnerships."https://s.yimg.com/rq/darla/4-10-0/html/r-sf-flx.html
Canadian retailer The Cheese Gallery commented, "We are so excited to have this new line of dairy-alternative products created by Canada's premier cheese expert Afrim Pristine and his partners at Future of Cheese! We are thrilled to have both the plant-based, ripened brie and the cultured butter available for our clients."
"We are very pleased by the overall response to the launch of our plant-based products," added Matt Lurie, CEO of Organic Garage. "Following the successful launch of the plant-based brie, we now have three SKUs that are in high demand and we are able to meet current and future needs from existing and new clients."
About Future of Cheese
The Future of Cheese Inc is a Canadian plant-based cheese innovator and manufacturer led by one of the world's best and recognized cheese makers, along with one of Canada's top chefs, and supported by a team of science minds and sustainability experts. Utilizing unique aging and manufacturing processes, a well-established distribution network and high-profile marketing channels, the Company is set to disrupt the rapidly growing plant-based dairy alternatives market, paving the way for the future of plant-based dairy alternatives! For more information please visit the Future of Cheese website at www.futureofcheese.com
About Organic Garage Ltd.
Organic Garage (TSXV: OG | OTCQX: OGGFF | FRA: 9CW1) is one of Canada's leading independent organic grocers and is committed to offering its customers a wide selection of healthy and natural products at everyday affordable prices. The Company's stores are in prime retail locations designed to give customers an inclusive, unique and value-focused grocery shopping experience. Founded in 2005 by a fourth-generation grocer, Organic Garage is headquartered in Toronto. The Company is focused on continuing to expand its retail footprint within the Greater Toronto Area. For more information please visit the Organic Garage website at www.organicgarage.com
ESE (OTC: ENTEF) to Organize Esports Competition with Riot Games, the Ultraliga Teamfight Tactics Championship Arcane


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Tucker 48 – samochód osobowy klasy pełnowymiarowej produkowany pod amerykańską marką Tucker w latach 1947–1948.

Historia i opis modelu

Rozwój
Po II wojnie światowej i kilkuletniej stagnacji na rynku samochodowym klienci oczekiwali nowości. Producenci z Wielkiej Trójki od kilku lat nie zaproponowali jednak żadnych nowych konstrukcji. Taka sytuacja stworzyła ogromne możliwości małym producentom i manufakturom, którzy w przeciwieństwie do dużych producentów mogli znacznie szybciej opracować i wdrożyć swoje pomysły. Studebaker jako pierwszy wprowadził na rynek zupełnie nowy powojenny model samochodu. Preston Tucker postanowił obrać inną ścieżkę rozwoju samochodów, projektując pojazd bezpieczny wyposażony w innowacyjne funkcje i nowoczesną stylistykę. W nowym samochodzie planowano wprowadzić chłodzony cieczą aluminiowy blok silnika. Miał to być płaski sześciocylindrowy boxer o pojemności 9,65 l, hamulce tarczowe, niezależne zawieszenia każdego koła, wtrysk paliwa, magnezowe koła, wysoką ergonomię wnętrza, a także pasy bezpieczeństwa, co w tamtym czasie było raczej niespotykanymi rozwiązaniami.

Jeszcze przed końcem wojny Preston Tucker rozpoczął prace nad nowym samochodem. Latem 1944 roku zatrudnił znanego projektanta Georgea S. Lawsona, który zajmował się pracami koncepcyjnymi. Lawson otrzymał miano "Głównego stylisty Tucker Corporation" w lutym 1946 roku, zaraz po utworzeniu Tucker Corporation.

W grudniu 1946 Lawson zrezygnował ze współpracy po licznych nieporozumieniach z Prestonem Tuckerem. Wkrótce potem do Tucker Corporation dołączył stylista Alex Tremulis z chicagowskiej projektowni Tammen & Denison, który rozwinął projekt Lawsona. Tucker udzielił Tremulisowi trzymiesięcznego kontraktu, który wygasł w marcu 1947 roku i nie został przedłużony. Dzieło wysiłków Tremulisa zostało zaprezentowane w broszurze reklamowej w wielu amerykańskich gazetach w 1947 r. Projekt Tremulisa opierał się bezpośrednio na pracy George'a Lawsona, jednak projektant włączył do wielu elementów swoje artystyczne koncepcje.

Alex Tremulis podobnie jak George Lawson, został ostatecznie mianowany "Głównym stylistą Tucker Corporation", pierwsze wzmianki o tym, że zajmuje on tę funkcję, pojawiły się dopiero w 1948 po zakończeniu prac nad zewnętrznym wyglądem Tuckera 48.

Równolegle z zakończeniem współpracy z Tremulisem, Preston Tucker zatrudnił zespół pięciu projektantów: Read Viemeister, Budd Steinhilber, Tucker Madawick, Hal Bergstrom i Phillip Egan z nowojorskiego Gordon Lippincott, którzy zaktualizowali rysunki Tremulisa. Po miesięcznej nieobecności Tremulis został ponownie zatrudniony dzięki czemu dwa niezależne zespoły opracowały dwa pełnowymiarowe konkurencyjne wobec siebie modele z gliny. Wzór Tremulisa pozostał w niezmienionej formie w stosunku do propozycji z marca 1947, przez co nie został skierowany do dalszych prac.

Cechy konstrukcyjne

Niektóre elementy i cechy samochodu były innowacyjne i wyprzedzały swoją epokę o 20 lat. Najbardziej charakterystycznym elementem Tuckera 48 jest kierunkowy trzeci reflektor umieszczony centralnie (znany również pod nazwą "oko cyklopa"). Automatycznie uaktywniał się przy kątach skrętu większych niż 10 stopni, co pozwalało na doświetlenie zakrętów. W tamtym czasie 17 stanów posiadało przepisy zabraniające większej liczby reflektorów niż dwa. Tucker wyposażył samochód w osłonę, która zakrywała dodatkowy reflektor, pozwalając na użytkowanie samochodu w tych stanach USA.

Pojazd miał silnik umieszczony z tyłu, napędzający tylną oś, wytrzymałą ramę nadwodzia w całości zintegrowaną z dachem, co wpływało na większą sztywność konstrukcji. Układ kierowniczy znajdował się za przednią osią co miało chronić kierowcę przed uderzeniami z przodu. Tablica wskaźników i wszystkie elementy sterujące znajdowały się w zasięgu ręki i oczu kierowcy, deska rozdzielcza była wyściełana materiałem dla większego bezpieczeństwa. Szyba czołowa była nietłukąca i zaprojektowana tak, aby w razie większej kolizji samoczynnie wypaść. Hamulec ręczny posiadał dodatkowy kluczyk zapobiegający kradzieży. Drzwi zachodziły na dach samochodu, aby ułatwiać wejście i wyjście z pojazdu. Każdy zbudowany egzemplarz różnił się nieco od poprzedniego, ponieważ każdy był zasadniczo prototypem, w którym wypróbowywano nowe cechy konstrukcyjne i koncepcje inżynieryjne, ulepszane lub odrzucane w całym cyklu produkcyjnym.

Wewnętrzna strona drzwi pochodziła z Lincolna Zephyr, Kolumna kierownicza użyta w Tuckerze została przekazana przez Forda i pochodziła z Lincolna z 1941 roku.

Schowek na rękawiczki został umieszczony w przednich drzwiach, zamiast tradycyjnie na desce rozdzielczej. Deska rozdzielcza stała się znacznie bezpieczniejsza dzięki brakowi wyżłobień i elementów które mogły ranić pasażera w razie kolizji.

Silnik i skrzynia biegów zamontowane zostały na oddzielnej ramie pomocniczej, która zabezpieczona była zaledwie sześcioma śrubami. W ten sposób cały układ napędowy w ciągu kilku minut można było wymontować z samochodu. Tucker zakładał, że silnik można było wymienić w czasie zaledwie 30 minut. Tucker przewidywał szereg innych pomysłów, które później zostały porzucone jak: hamulce tarczowe, wtrysk paliwa, opony bezdętkowe samouszczelniające, bezpośrednie przełożenie napędu. Ostatecznie w związku z wysokimi kosztami, problemami natury technicznej i brakiem czasu na dopracowanie nie zostały wprowadzone.

Tucker pragnął stworzyć innowacyjny silnik. Z pomocą Bena Persona, ówczesnego właściciela i prezesa Fuelcharger Corporation, a następnie głównego inżyniera Tuckera zaprojektowano silnik pod nazwą Tucker 589 (589 oznacza cale sześcienne, czyli 9,65 l). Był to płaski sześciocylindrowy silnik z półsferycznymi komorami spalania, wtryskiem paliwa i zaworami sterowanymi ciśnieniem, a nie wałkiem rozrządu. Rozdzielacz ciśnienia zamontowany w linii z aparatem zapłonowym dostarczał odpowiednio dobrane czasowo ciśnienie, aby otworzyć każdy zawór w odpowiednich odstępach czasu. Silnik posiadał duże tłoki zbudowane z aluminiowych i magnezowych odlewów ze stalowymi okładzinami cylindrów. Silnik został zaprojektowany do pracy na biegu jałowym z prędkością 100 obrotów na minutę i obrotami w czasie jazdy od 250 do 1200. Przełożenie napędu odbywało się poprzez przekładnie hydrokinetyczną.

Silnik osiągał 200 KM (150 kW) i 660 Nm momentu obrotowego. Podczas jazdy z prędkością 97 km/h obroty silnika wynosiły około 1000 obr./min. Te cechy wyróżniały konstrukcję na tle konkurencji. Powstało sześć prototypów, które zostały zainstalowane tylko na podwoziu testowym i pierwszym prototypie.

Kłopotliwa premiera
Światową premierę bardzo oczekiwanego Tuckera 48 zaplanowano na 19 czerwca 1947 roku. Na prezentację przybyło ponad 3000 osób. W związku z problemami jakie pojawiły się w ostatniej chwili premiera była poważnie zagrożona. W noc poprzedzającą premierę pękły dwa wahacze pod ciężarem samochodu (prototyp był znacznie cięższy niż kolejne pojazdy). Wystąpiły usterki silnika, z którymi sobie szybko poradzono. Eksperymentalny silnik 589 był bardzo głośny. Tucker nakazał grać orkiestrze bardzo głośno, aby jak to tylko możliwe zagłuszyć hałas silnika. Dodatkowym problemem był rozrusznik, który wymagał zewnętrznego zasilania do uruchomienia silnika. Z tych powodów Tucker zatrzymał zespół mechaników, którzy mieli dbać o to, aby samochód w ogóle mógł się poruszać o własnych siłach. Kiedy premierowy egzemplarz był wprowadzany na platformę zagotował się płyn chłodzący.

Drew Pearson, jeden z czołowych publicystów tamtych czasów spostrzegł, że samochód nie potrafił jeździć do tyłu i nazwał całą sprawę oszustwem, co spowodowało nadwątlenie reputacji i spotkało się z dużą nieprzychylnością prasy.

Kolejną porażkę Tucker poniósł, gdy jego oferta na dostarczenie stali niezbędnej do produkcji zostały odrzucone przez War Assets Administration, decyzja miała charakter polityczny.

Silnik

Początkowo obiecywano moc 150 KM, ale silnik nie działał zgodnie z założeniami. Układ zaworów okazał się problematyczny, a silnik osiągał jedynie 88 KM. Wysokie ciśnienie oleju wymagało 24V układu zasilania, a do rozruchu było potrzeba 60 V oraz bardzo długiego czasu do osiągnięcia stabilnej pracy. Po wielu problemach i roku bezowocnej pracy ostatecznie zaczęto poszukiwania alternatywny dla niesprawnego i niedopracowanego silnika. Początkowo próbowano wykorzystać silnik samolotowy Laycoming, ale nie było możliwości sensownego umieszczenia go w tylnej komorze silnika.

Znacznie mniejsze problemy sprawił chłodzony powietrzem rzędowy sześciocylindrowy silnik Franklin O-355 stworzony przez Air Cooled Motors, który oryginalnie był przeznaczony dla śmigłowca Bell 47. Zakupiono cztery egzemplarze za 5000 dolarów od sztuki. Inżynierowie Tuckera przerobili chłodzenie z powietrznego na ciecz. Jednostka napędowa została znacząco przebudowana przez zespół Tuckera, w tym Eddiego Offutta i syna Tuckera, Prestona Jr. Wykorzystanie silnika lotniczego wymagało znacznych modyfikacji, w ten sposób niewiele elementów oryginalnego silnika zostało zachowanych w ostatecznej wersji. Zmodyfikowana jednostka testowana była przez 150 godzin, co odpowiadało pokonaniu dystansu 29.000 km.

Tucker po pomyślnych testach wykupił Air Cooled Motors za kwotę 1,8 mln USD, aby zabezpieczyć źródło dostaw. Następnie anulował zamówienia na silniki do samolotów, aby wszystkie zasoby skupić na produkcji silników samochodowych. Była to ważna decyzja, ponieważ Air Colled Motors posiadał 65% powojennych umów na produkcję silników lotniczych w USA. Strata dochodów była znacząca.

Zawieszenie i karoseria
Konstrukcja zawieszenia, zwłaszcza przedniego, musiała zostać zmieniona w trakcie prac rozwojowych. Zamiast stalowych sprężyn użyto elastomerowego niezależnego zawieszenia na cztery koła, podobnego do tego jakiego użyto w samochodach wyścigowych, które opracowano z Harrym Millerem dla samochodów biorących udział w wyścigach Indianapolis 500. Elastomery zostały opracowane przy udziale firmy Firestone, która wykorzystała specjalny proces wulkanizacji.

W samochodach zastosowano trzy wersje przedniego zawieszenia. Samochody o numerach 1001–1002 wykorzystywały gumową konstrukcję ze skrętną rurką, która ulegała silnemu przechyłowi podczas hamowania. W samochodach 1003–1025 przerzucono się na gumowe zawieszenie typu sandwich (z gumowym klockiem umieszczonym pomiędzy górnym i dolnym ramieniem typu A), jednak takie zawieszenie cechowało się bardzo dużą sztywnością. Ostatecznie od samochodu 1026 zdecydowano się na pierwotną wersję z poprawionym problemem hamowania.

Oryginalne kody kolorów nadwozia:
 100: Black
 200: Waltz Blue
 300: Green
 400: Beige
 500: Grey (Silver)
 600: Maroon

Oryginalne kolory wnętrza:
 900: Green
 920: Blue
 940: Beige

Finansowanie i promocja
Po zebraniu pierwszych 17 mln dolarów w jednej z pierwszych ofert publicznych, nadal potrzebne były środki pieniężne do kontynuacji rozwoju. Jednym ze sposobów pozyskania pieniędzy była sprzedaż akcesoriów takich jak pokrowce, radio czy siedzenia. Kupno akcesoriów zapewniało miejsce na liście oczekujących. Działanie to przyniosło dodatkowe 2 mln dolarów.

Po zakończeniu projektowania, Preston Tucker zabierał pojazdy przedprodukcyjne na drogę, aby prezentować je w miastach całego kraju. Samochody odniosły natychmiastowy sukces, a tłumy gromadziły się wszędzie, gdzie się zatrzymały.

Aby udowodnić jakość swoich samochodów, Tucker i jego zespół poprowadził kilka samochodów na torze Indianapolis Motor Speedway w testach wytrzymałościowych. Podczas jednego z testów samochód o numerze 1027 koziołkował przy prędkości 153 km/h, a kierowca (główny mechanik Eddie Offut) wyszedł z samochodu jedynie z kilkoma siniakami. Podczas koziołkowania zgodnie z przewidywaniami szyba czołowa samoczynnie wypadła. Następnie po wymianie uszkodzonej opony, samochód o własnych siłach opuścił tor.

Śledztwo i upadek projektu

Jeden z najbardziej innowacyjnych pomysłów Tucker Corporation sprowadził na firmę największe kłopoty. Był to program zakupu akcesoriów jeszcze zanim samochód został wyprodukowany. Po wojnie popyt na nowe samochody przewyższał podaż. Większość dealerów miała listy oczekujących, gdzie pierwszeństwo mieli powracający z wojny weterani. Program zakupu akcesoriów pozwalał na zagwarantowanie miejsca na liście nawet dla nieweteranów.

W komunikatach prasowych Tucker 48 mocno ewoluował w stosunku do wcześniejszych wizualizacji, co w połączeniu z sugestywnym hasłem "15 lat testów, aby stworzyć samochód roku", braku działającego prototypu i wieloletniego oczekiwania po wpłaceniu środków przez klientów było jedną z przyczyn wszczęcia postępowania przez Komisję Papierów Wartościowych, która postawiła zarzuty oszustwa i wyłudzeń. Komisja nie udowodniła nigdy takich działań, a sam Tucker został uwolniony od zarzutów w styczniu 1950 roku. Mimo że nie udowodniono działania na szkodę kupujących negatywna reklama zniszczyła firmę i ostatecznie zatrzymała produkcję.

Tucker 48 po latach
Do zakończenia produkcji 3 marca 1949 roku z fabryki wyjechało 51 egzemplarzy Tuckera 48, do czasów nowożytnych zachowało się 47 egzemplarzy. Tucker 48 określany był jako "tylnosilnikowy zwiastun rewolucji konstrukcyjnej".

W październiku 2021 na amerykańskim portalu ogłoszeniowym eBay wystawiono na sprzedaż jedyny zbudowany w historii egzemplarz Tuckera 48 z nadwoziem 2-drzwiowego kabrioleta, którego wyceniono na 2,5 milona dolarów.

Samochody Tucker 48
Pierwszym prototypowym wyprodukowanym egzemplarzem był sedan zwany "Tin Goose". Zostało wyprodukowanych 58 ram podwozia i tyle samo gotowych elementów nadwozia. Z tych złożono 36 egzemplarzy przed zamknięciem fabryki. Po zamknięciu, ale jeszcze przed likwidacją fabryki zbudowano dodatkowo 14 egzemplarzy, co dało łączą liczbę 50 wyprodukowanych samochodów. 51. egzemplarz został częściowo ukończony. Kilka pozostałych ram i nadwozi zostało jeszcze w późniejszym czasie złożonych w kompletne pojazdy, w szczególności numer 1052 i 1057 (prototyp z 1949 roku ze zmianami projektowymi). Los pozostałych nie jest znany.

We wczesnych latach pięćdziesiątych XX wieku właściciel wesołego miasteczka z Florydy zakupił dziesięć Tuckerów, oryginalne podwozie testowe, liczne części, zdjęcia i dokumenty. Opracował program "Bajeczne Tuckery", jeżdżąc po kraju woził samochody i pamiątki przez 10 lat, bardzo często stawiając się na targach i pokazach motoryzacyjnych.

Samochody bardzo rzadko pojawiają się na aukcjach i uznawane są za unikaty. W sierpniu 2010 roku Tucker numer 1045 sprzedano za 1,127 mln dolarów, podczas gdy Tucker 1043 Został sprzedany za kwotę 2,915 mln dolarów na aukcji w 2012 roku.

Przed zamknięciem fabryki

Po zamknięciu fabryki

Tucker 48 w kulturze
Film Tucker: Konstruktor marzeń z 1988 roku opowiada o problemach na jakie natknęli się konstruktorzy i przeciwnościach z jakimi musieli się zmierzyć. Reżyser filmu Francis Ford Coppola jest właścicielem dwóch egzemplarzy Tuckera 48, o numerach nadwozia 1014 i 1037. Początkowa, sugerowana cena samochodu wynosić miała 1000 dolarów, ale rzeczywista cena szybko urosła do 4000 dolarów.

Samochód powszechnie określany jest jako "Tucker Torpedo". Jednakże nazwa ta nigdy nie była używana w połączeniu z rzeczywistym modelem produkcyjnym ze względu na żywe jeszcze wspomnienia związane z wojną II Wojną Światową. Oficjalna nazwa pojazdu to "Tucker 48".

Przypisy

48
Samochody z lat 40.
Sedany
Samochody tylnonapędowe


text:
Image credit: Jack Sprat
House Coronavirus Bill Includes Cannabis Banking Reform
The SAFE Banking Act has been included in the HEROES Act. Whether the language will survive the Senate is another question.
Published on May 12, 2020 3:27PM EDT Congress
Alyson Martin	@alysonrmartin
Will COVID-19 legislation be the vehicle for cannabis banking? Maybe.
After trying, and failing, to ensure that cannabis businesses would have access to federal coronavirus aid, advocates have pushed for a different financial shot in the arm, one with implications far beyond the pandemic: banking access.
The House's new coronavirus bill, known as the HEROES Act, includes the Secure and Fair Enforcement (SAFE) Banking Act, which, in short, would eliminate consequences for banks and other financial institutions that work with cannabis businesses, thus expanding cannabis industry access to financial services.
"The inclusion of the SAFE Banking Act is recognition that cannabis businesses have been classified as essential. Prohibiting these businesses from banking and forcing cash-only transactions in the middle of a global health crisis is irresponsible and wrong," Oregon Rep. Earl Blumenauer told Cannabis Wire. Blumenauer is also the co-chair of the Congressional Cannabis Caucus.
"We were able to ensure small business owners are no longer disqualified or ineligible for the Paycheck Protection Program solely because of their involvement with the criminal justice system. The passage of the bipartisan SAFE Banking Act will be a huge benefit, not only to the industry but to our communities and public safety."
Colorado Rep. Ed Perlmutter told Cannabis Wire that he will "continue working to ensure" that the SAFE Banking Act, which has already passed "by an overwhelming majority" in the House, "remains included in the HEROES Act and signed into law."
"The SAFE Banking Act will help reduce the existing public safety risk posed to cannabis businesses and exacerbated by the COVID-19 crisis and provides some financial relief to the industry by allowing legitimate cannabis businesses access to the banking system," Perlmutter said.
This legislation has seen more lobbying from within and outside the cannabis industry than any other cannabis related bill, perhaps in history, and the only one ever to get voted out of the House. (Though it has since stalled in the Senate.) As Cannabis Wire has reported, counties and cities across the US, major banks and insurance companies, and even less-than-expected entities like Brinks Security Company and the National Rifle Association, have all chimed in on the bill.
"We strongly support the SAFE Banking Act, and continue to urge lawmakers to resolve the conflict between state and federal law so banks can provide services to cannabis-related businesses in states where it is legal," Blair Bernstein, spokesperson for the American Bankers Association, told Cannabis Wire.
Since March, cannabis advocates, the cannabis industry, and cannabis-friendly lawmakers have all been pushing to ensure that state-legal cannabis companies could access coronavirus-related federal aid, specifically from the Small Business Administration. As Cannabis Wire reported, efforts ranged from multiple letters sent to lawmakers to the introduction of legislation.
(Read Cannabis Wire's interview with Oregon Senator Ron Wyden about his efforts around coronavirus-related relief for the cannabis industry.)
Those efforts have been, so far, unsuccessful. Then, on May 8, several cannabis groups, including the Marijuana Policy Project, Minority Cannabis Business Association, National Cannabis Industry Association, National Cannabis Roundtable, National Organization for the Reform of Marijuana Laws, and Policy Center for Public Health and Safety, among others, sent a letter to Congress suggesting that the SAFE Banking Act "or similar language" be included "in the next pandemic relief package."
Why? "The ability of cash to carry contagions and the personal proximity required by cash transactions."
On Tuesday, cannabis groups applauded the inclusion of the SAFE, and language preventing denial of SBA loans to those with criminal convictions, while NORML also called out the absence of SBA-related language for the cannabis industry.
"The inclusion of the SAFE Banking Act in the CARES 2 package is a positive development, but one that's akin to applying a band-aid to a gaping wound," said NORML Political Director Justin Strekal. "While larger, better capitalized players may be able to weather this storm, smaller cannabis businesses may not be able to do so absent some economic stimulus."
The full House will now consider the bill. And the cannabis language, as has been the case with previous cannabis legislation, faces a steep climb in the Senate, where Republicans are in control.
"It appears that passing any relief bill in the Senate may be a heavy lift. That being said, stripping this language out of a relief package will likely be a low priority for that chamber," National Cannabis Industry Association spokesperson Morgan Fox told Cannabis Wire.
"Beyond that, I think we have to watch how the negotiations go and see what the political climate is like at that time."
This story was updated to include comment from Oregon Representatives Earl Blumenauer and Ed Perlmutter, the American Bankers Association, and the National Cannabis Industry Association.


Springfield, IL – While the Legislature is still in the midst of its summer recess, there was activity this week involving two special committees tasked with addressing issues surrounding the state's Medicaid Reform plan passed last year and tackling the thorny issue of education funding fairness. Meanwhile, this week was also Constitution Week marking the 226th anniversary of the adoption of the US Constitution.
At the center of the joint House and Senate Appropriations Committee hearing Sept. 17 on Medicaid Reform (which I attended) was the state's contract with Maximus, a company hired to remove ineligible individuals from the state's Medicaid program. The contract was a key component of the 2012 bipartisan Medicaid reform effort. However, in June an arbitrator agreed with the union that using a third party vendor to review Medicaid eligibility violates the state's contract with the state employees union AFSCME (American Federation of State, County and Municipal Employees).
During the hearing, state officials said they plan to appeal the arbitrator's ruling. According to Department of Healthcare and Family Services (HFS) Director Julie Hamos, Maximus has reviewed approximately 15 percent of the state's Medicaid cases and has already saved taxpayers $44 million with about 125,000 ineligible individuals having been removed from the program.
Also meeting this week was the bipartisan Senate Advisory Committee on Education Funding, which heard testimony about an independent review of Illinois' school finance system. The report revealed the state has moved away from long-standing funding formulas, originally intended to equalize funding for Illinois schools. It indicated the state's use of poverty grants has increased dramatically over the last ten years, which has contributed to the funding imbalance between schools in Chicago, suburban and downstate. The Illinois State Board of Education (ISBE), which testified at the hearing, confirmed that over the last decade poverty grant funding has increased from $300 million each year to $1.8 billion annually.
Earlier this year, a report made public by Senate Republicans showed while only 18 percent of the state's students attend Chicago Public Schools (CPS), CPS receives 48 percent of the state's poverty grants. What is more troubling is that the state's steady increase in allocations to the poverty grant program is a funding decision that has occurred with limited review or input from policy makers or the public.
Although poverty grants vary from school district to school district, some metropolitan schools receive nearly eight and a half times the funding compared to some downstate schools. In some situations the imbalance is quite notable. In fact, CPS poverty grant students qualify for $3,000 in funds versus some downstate schools that only receive $355 per pupil.
Obviously, high poverty schools require greater resources than those schools with lower poverty rates but it's also clear the considerable disparity in the allocation of this funding deserves greater review.
During the hearing, Senate Republican members also questioned why CPS receives guaranteed block grants each year for special education and early childhood education dollars while suburban and downstate schools must submit paperwork to the State Board of Education for review. Another interesting revelation to come out of the hearing this week was an admission by ISBE Superintendent Christopher Koch that overall education funding, from federal, state and local funding, has actually increased 55 percent during the past decade, which is in contrast to the more widely accepted popular notion is that education funding in Illinois has decreased.
Meanwhile, the Senate Advisory Committee on Education Funding is tentatively scheduled to meet again in mid-October and ISBE said it would provide guidance and suggestions on achieving a fair and equitable funding formula at that time.
Finally, this week was Constitution Week, marking the 226th anniversary of the adoption of the US Constitution on September 17, 1787. Perhaps the most incredible part of our Constitution is how it was crafted by the Founding Fathers. Until the US Constitution, never before in the history of the human race or since has any government been founded on the principle that those who govern, govern only by the consent of the people. The United States of America is unique in that regard and it's is a great responsibility and legacy that we all must share in defending, protecting and passing down to future generations. Constitution Week was officially enacted on August 2, 1956 by President Dwight D. Eisenhower from a congressional resolution petitioned by the Daughters of the American Revolution, but it wasn't publicly declared until President George W. Bush officially did so 11 years ago this month.
While we're on the subject of constitutions, there is currently an effort underway to amend the Illinois Constitution which would limit legislators and Constitutional officers to eight years of service. I believe it is critical for the future of our state that we return to citizen legislators instead of career politicians. Only then will our legislators vote for what is good for our state instead of what they perceive to be good for their reelection. In addition to term limits, the Amendment would reduce the number of state Senators to 41 from 59 and divide each Senate district into 3 house districts instead of the current 2. It would also increase the majority needed to override a Governor's veto to two-thirds from the current 60%.


text:
/* Ce code est une repompe assez directe de celui-ci :
 * http://powerof2games.com/node/10
 */
#include <cstdio>
#include <cstdarg>

#include <Core/Debug/Assert.h>
#include <Core/Debug/CallStack.h>
#include <Core/Logger.h>

namespace Core { namespace Assert
{
void doNothing()
{}

static bool sAssertBreak = true;

void activateAssertBreak(bool active)
{
    sAssertBreak = active;
}

struct AssertHandler
{
    AssertHandler()
        : handler(&AssertHandler::DefaultHandler)
    {
    }

    static bool DefaultHandler(const char* condition, const char* msg, const char* file, const int line)
    {
        std::printf("%s(%d): Assert Failure: ", file, line);

        if (condition != NULL)
            std::printf("'%s' ", condition);

        if (msg != NULL)
            std::printf("%s", msg);

        std::printf("\n");
        std::fflush(stdout);

        ERR << L"ASSERT failed : " << String(condition) << L" @ " << String(file) << L":" << Core::toString(line) << L"\n";

        String cs;
        Core::getCallStack(cs);
        ERR << cs;

        return sAssertBreak;
    }

    Handler handler;
};

AssertHandler& GetAssertHandlerInstance()
{
    static AssertHandler s_handler;
    return s_handler;
}

Handler GetHandler()
{
    return GetAssertHandlerInstance().handler;
}

void SetHandler(Handler newHandler)
{
    GetAssertHandlerInstance().handler = newHandler;
}

bool Report(const char* condition, const char* msg, const char* file, const int line)
{
    return GetAssertHandlerInstance().handler(condition, msg, file, line);
}

bool ReportFormatted(const char* condition, const char* file, const int line, const char* msg, ...)
{
    if (msg != NULL)
    {
        char messageBuffer[1024];
        {
            va_list args;
            va_start(args, msg);
#if defined _MSC_VER
            vsnprintf_s(messageBuffer, 1024, _TRUNCATE, msg, args);
#else
            vsnprintf(messageBuffer, 1024, msg, args);
#endif
            va_end(args);
        }

        return Report(condition, messageBuffer, file, line);
    }

    return Report(condition, NULL, file, line);
}
}}

redpajama_set_name: RedPajamaGithub


"FATHER, . . . this is eternal life, that they may know you, the only true God, and Jesus Christ whom you have sent."1 "God our Savior desires all men to be saved and to come to the knowledge of the truth."2 "There is no other name under heaven given among men by which we must be saved"3 - than the name of JESUS.
9 "The ministry of catechesis draws ever fresh energy from the councils. The Council of Trent is a noteworthy example of this. It gave catechesis priority in its constitutions and decrees. It lies at the origin of the Roman Catechism, which is also known by the name of that council and which is a work of the first rank as a summary of Christian teaching. . . ."12 The Council of Trent initiated a remarkable organization of the Church's catechesis. Thanks to the work of holy bishops and theologians such as St. Peter Canisius, St. Charles Borromeo, St. Turibius of Mongrovejo or St. Robert Bellarmine, it occasioned the publication of numerous catechisms.
10 It is therefore no surprise that catechesis in the Church has again attracted attention in the wake of the Second Vatican Council, which Pope Paul VI considered the great catechism of modern times. The General Catechetical Directory (1971) the sessions of the Synod of Bishops devoted to evangelization (1974) and catechesis (1977), the apostolic exhortations Evangelii nuntiandi (1975) and Catechesi tradendae (1979), attest to this. The Extraordinary Synod of Bishops in 1985 asked "that a catechism or compendium of all Catholic doctrine regarding both faith and morals be composed"13 The Holy Father, Pope John Paul II, made the Synod's wish his own, acknowledging that "this desire wholly corresponds to a real need of the universal Church and of the particular Churches."14 He set in motion everything needed to carry out the Synod Fathers' wish.
14 Those who belong to Christ through faith and Baptism must confess their baptismal faith before men.16 First therefore the Catechism expounds revelation, by which God addresses and gives himself to man, and the faith by which man responds to God (Section One). The profession of faith summarizes the gifts that God gives man: as the Author of all that is good; as Redeemer; and as Sanctifier. It develops these in the three chapters on our baptismal faith in the one God: the almighty Father, the Creator; his Son Jesus Christ, our Lord and Savior; and the Holy Spirit, the Sanctifier, in the Holy Church (Section Two).
16 The third part of the Catechism deals with the final end of man created in the image of God: beatitude, and the ways of reaching it - through right conduct freely chosen, with the help of God's law and grace (Section One), and through conduct that fulfills the twofold commandment of charity, specified in God's Ten Commandments (Section Two).
22 At the end of each thematic unit, a series of brief texts in small italics sums up the essentials of that unit's teaching in condensed formula. These IN BRIEF summaries may suggest to local catechists brief summary formula that could be memorized.
13 Extraordinary Synod of Bishops 1985, Final Report, II B a, 4.
14 John Paul II, Discourse at the Closing Of the Extraordinary Synod of Bishops, 7 December 1985: AAS 78, (1986).
18 Roman Catechism, Preface II; cf. 1 Cor 9:22; 1 Pt 2:2.
19 Roman Catechism, Preface 10; cf. 1 Cor 13:8.


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Autism, if you are not scared, you ought to be. A disease or disability can affect your physical and psychological ability to perform your work satisfactorily and could place your long-term career prospects, along with current employment, in danger. Rather than relying solely on pills or surgery, patients should get an alternative option that is strikingly potent and more cognizant of the person all-around wellness. In the close of the see the doctor asked us to think about the flu vaccine. Therefore, if you are interested to receive free medicine or medication for your health care, here is how to receive it. Because the moment you try us, you can not go back to the early way of growing health care.
Don't use letterhead unless you're instructed to attain that. Your letter needs to be composed in a style that's very clear and succinct. An official letter offers proof of your request and outlines several vital characteristics of your leave, like the date you want your leave to begin and the expected length. Saying goodbye was not fast. If your leave is due to medical reasons, a note or other documentation in your wellbeing care provider may be required. Start your letter by mentioning that you're asking a leave. Write the exact time period you are asking unpaid leave. Time to go ahead from your current company and locate new opportunitiesI get it. So, at the conclusion of the day, only you may say whether you're an alcoholic or not.
Supply your contact number and allow it to be quite clear that you will be content to answer questions. You're experienced afterward not a matter. Tell your supervisor that you're writing to talk about a matter that you have. In case the problem is personal, you don't need to offer details you are uncomfortable giving. Check your organization's policy to establish how much notice you're expected to provide. Explore your leave options before making your request. Ultimately, following is a sample email you can use as a template.
Any company is dependent on the standard of this service you offer to your customer. Besides the letter, your company may ask you to complete a request for leave form. As a way to qualify to sit down on a board as an unaffiliated member, an individual shouldn't have been involved with the business in the past five decades. The company will lead the approaching construction and maturation of this laboratory. Most private businesses finally have separate boards. If you would like to observe an innovative, sustainable digital wellness company continue to exist in Earth, please connect Sherpaa now or any time you require medical attention later on.
If you've got an adventure of handling numerous calls, then notify them you are able to deal with. Go to your regional Walgreens Store and deliver your records to show that you are out of job and don't have any medical insurance. If you left your job to observe over a parent, and you are going to be able to confirm your parent has a critical illness and is clinically determined upon your maintenance, you may qualify for unemployment benefits. If you have been unhappy with your job, a statement like I have resolved to pursue different choices for private reasons" is sufficient. Propose a training session for a direct employee who could be in a position to take over the job you were doing. In fact, quitting the job doesn't need to be a nerve-wracking choice. Though resigning may cause you to get thrilled, you don't wish to convey that you are happy about leaving the situation.
Whenever it is not always prudent to present the precise reasons for quitting, it may help your working relationship when it is likely to communicate a general reason. Leaving a significant expert dedication is never a simple choice, but if you are sure you are making the appropriate option, you can leave the position at a positive manner. Or, if at all possible, you might suggest you can assume that the responsibilities without needing to move. The goal of an independent board would be to be sure members are not affected by interests in the business. Leave without pay is a decision that's made by the employer or the employee in situations where the employee should be away from his work and will not be compensated. Evidently, the suggested fee doesn't incorporate any copying costs, though Faircloth has been advised to ask any records electronically to stop such costs in the future.
When a worker is unable to report to work because of illness or circumstances beyond her hands, she should notify the proper person that has a call. Explain to your company that you are able to contribute more where you are at currently. The employer should know precisely why you think you're unable to function on your position for a time period. If you are genuinely a valuable employee, your employer will attempt to work out something.
There are numerous types of meetings based on the gist of the business and what a company wishes to realize. Before organizing a meeting, it is necessary to know what should be done before a meeting to prepare a smooth stream of your assembly. You are going to need several meetings here in order to reach a few drafts of the app. 1 major reason most meetings become inefficient is typically caused by the dearth of proper planning and agenda. The meetings were embarrassing sometimes. For example, when assembly in Europe, invite the KM leaders from all of the European nations, but just a few vital leaders from a few other regions.
The importance of the four unique agendas will ensure you get the proper answer from participants in the assembly and the idea on what to anticipate. There are particular characteristics of a meeting in order for it to be considered productive. It's necessary to know the elements in a meeting agenda to ensure it is less difficult for you to make one without leaving the vital components.
The local government conducts internal training to be certain that staff can make decent use of organizational information within their daily work. It provides access to trainings for many local authorities personnel about the best way to use evidence and data to make decisions. It seeks relationships with outside researchers who might have the ability to use organizational information to provide the local authorities with useful insights. Mexico City's Authorities will also receive a tiny percentage of their yearly income. Policies have stripped employees' rights in order to get more flexibility used.
The science of helping others Research has shown that women desire to actually make a difference on earth. Education raises opportunity for everyone. You will get an application that will make hitting your targets a lot more likely. The CMS program is meant to deliver a thorough overview of campaigns. The implementation plan makes sure that the KM program is put into action so as to accomplish the Top 3 Objectives formerly identified. If you've got that, you'll have more than the usual plan. The entire plan of record should be maintained on an easily-accessible web website. Agendas also allow a recap of the previous meeting, which is vital to understand more about the progress made and the condition of the company. Since the team leader, you have got to have the schedule, otherwise you'll have anarchy in your palms and no one is very likely to thank you for that. Our Meeting Agenda and Board Meeting Agenda samples may also be helpful to you, click the hyperlinks to test on the assortment of forms and samples which you might download.
Utilizing a meeting agenda cannot only benefit the people but the entire progress of a company or company. Meeting agendas are useful for plenty of unique facets. Developing a meeting agenda will ensure it's simpler for everyone to speak about about the main topics without the prospect of forgetting about the main info. It's crucial to learn the way to make the very best meeting schedule to have the ability to make meetings easier not only for the presenter but also for the participants.
A project leader should execute these tasks. After the team has the capacity to comprehend the matter, they must come together to be able to get to the very best choice to resolve the matter. Implementing a round-robin approach, each group member briefly presents, but doesn't talk about, the very first thought on their listing. Cabinet members may take part and offer advice and information, but do not have voting rights. Your board members will most likely provide you with feedback after each meeting. Late participants should not be permitted entrance in a meeting room to stop disruption and distractions from the continuing meeting. If a player has the capability to assist the person requesting the help, both parties can meet away from the assembly to go over the process of solving it.
The comments about things you are able to improve part of this meeting is the important thing to concentrate on for a worker who is struggling. Before creating a schedule, it's essential to be aware of the parts and also the information needed in creating the perfect meeting agenda to make certain that the efficiency of a meeting. In front of a company meeting, it's essential to be prepared on the crucial topics that will be tackled in a meeting. Remind the group your job is to keep up the discussion focused and effective. The thought of working via the internet has begun to creep into the regular office,… Read , an attractive agenda that's also practical is the best way to go. There's also space provided for a basic introduction to your agenda.
In case you haven't prepared an agenda in a day of this meeting, you may want to postpone. Other regions of the agenda seem to be a summary using Roman numerals to recognize board items for discussion. A meeting's agenda can only be deemed as leader that leads towards the expert ending. Developing a meeting agenda serves two principal functions. Financial meeting agendas are related to encounters that are called for financial pursuits and resolving and talking financial requirements of any organization.
A program supplies you with a roadmap to ensure you are covering what you desired to chat about, and it immediately relieves a lot of anxiety and tension that the salespeople could be feeling in the assembly. If you own a lot to get through, you're likely to want to have a more comprehensive agenda. In other words, a successful meeting agenda is an essential component to produce the meeting effective and it's usually ready for all sort of encounters.
The agenda may be utilized as the proof when the agent can not recall or know some points. It can help the leader to replicate the things for the people that are late. The informal meeting agenda also has to be developed in case of casual meeting and ought to also be conveyed to all the participants.
To operate, agendas should be followed and used with consistency and fidelity. Meeting agenda is like blueprint of the coming assembly which helps assembly attendees to be prepared for the meeting so as to get involved in the assembly positively. You must produce the schedule for the business meeting within the business or between companies. It will steer you when distracted and, at the wee hours of the morning as soon as your willpower is reduced, it will provide you with a objective to kickstart your daily life and accomplish something while the rest of the planet is still waking up. It will guide you when distracted and, in the early hours of the morning as soon as your willpower is reduced and it's difficult to consider, it will supply you with a goal to kickstart your day and reach something while the rest of the world is still waking up. Just take the individual who wishes to write a business program.
Board members should make an effort to comprehend the financial reports in order that they can identify possible financial threats. They should have a talk about new business items and identify a plan to do it. In most cases, they should have received a copy of those minutes before the meeting.
The main reason is because the template can differ from 1 company to the other. It's possible to see also straightforward agenda templates. The casual agenda template is perfect for team meetings. The absolutely free meeting agenda templates are available online. The meeting schedule templates that are available online have all of the fields that cover the many different aspects of a meeting.
If you're sure you have a purpose, here's where to begin. Exactly like every agenda it's important to confirm the intention behind the meeting. The second principal objective is to allow participants understand what the assembly is all about and what is expected from them. It's also sensible to let folks understand the most important intention of the discussion.
The meetings were embarrassing occasionally. In the event you have ever attended or planned a board meeting, you then see that the agenda involves a great deal more information than an simple team meeting schedule. Starting a board meeting with a very clear purpose and program helps members understand exactly the main reason why they are there and what things to expect.
Read More and should you never plan meetings regularly, then it's logical, especially if you like doing it. If it resembles the meeting is likely to operate long, wrap up this without a selection. To be called productive, a meeting has to be necessary, it has to serve a goal, it must deliver a result, and it needs to be an effective utilization of everyone's time. In accordance with processionals if you would like to hold a flourishing assembly then you need to prepare a meeting agenda in advance. When it is going to be a participatory meeting, choose the tone of the discussion beforehand and note it to the schedule. Other people suggest requiring every individual to stand up for the entire assembly.
With Agilean, you merely focus on the assembly and let its agile oriented AI engine manage the rest. You don't always require everyone to be there for the whole meeting. Business assembly is a significant schedule on your office.


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Odochilus parajohnsoni är en skalbaggsart som beskrevs av Rakovic 1997. Odochilus parajohnsoni ingår i släktet Odochilus och familjen Aphodiidae. Inga underarter finns listade i Catalogue of Life.

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The August Indie Next List flier, now on its way to stores in the IndieBound movement, features the month's Indie Next Great Reads, Now in Paperback titles, and Revisit & Rediscover backlist favorites.
Beginning August 1, titles will be featured on downloadable fliers and shelf-talkers on BookWeb.org and IndieBound.org.
Carousel Court: A Novel, by Joe McGinniss Jr.


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Technology becoming a great equalizer for students with special needs
By Samuel Gilstrap, LA Unified School District Daily
Students in L.A. Unified face unique challenges when it comes to achieving in the classroom – many of them dealing with disabilities that create barriers to learning or inhibit their ability to get to a classroom at all.
But high-tech devices are creating new opportunities for youngsters with limited mobility or other disabilities that may constrain their ability to learn.
Assistive technology can be – in a sense – magical," said Kari Tapie, who coordinates the Assistive Technology Program in L.A. Unified's Division of Special Education. "It can provide a sense of empowerment for students by virtue of their ability to do things previously believed to be impossible."
To help educators determine what device is the most appropriate for a student, L.A. Unified is opening assistive technology "lending libraries" at locations throughout the District. More akin to a showroom than a library, the displays include models of high-tech devices that may eventually be purchased to help students access their curriculum.
Meet Christopher Leon, user of assistive technology and accomplished artist
Christopher Leon is among students that have been assisted by VGo, a robotic machine that replicates a person's presence in a remote location. Students who are physically unable to attend school can still be present in the classroom, thanks to a wheeled machine equipped with a camera, microphone and screen. With just the touch of a finger trigger or other input device, students can see, hear, move around and communicate.
Diagnosed with spinal muscular atrophy at an early age, Christopher has been home bound since first grade. Thanks to the opportunity to be a "test driver" of the VGo device, he has been attending classes at Verdugo Hills High School for the past two years and is set to graduate this spring. Through the process, he has developed friendships, attended school events, and had the chance to overcome what he describes as a shy personality. He plans to be present for his graduation.
Christopher was present via his VGo device at the recent open house of the lending library at Plummer Elementary School. There, he used his device to talk about his artwork on display and his post-graduation plans.
"At first I plan to study artistic design at Santa Monica College," he said through his screen. "Later I want to attend the Art Institute in San Francisco."
It's not a surprise to hear that Christopher is passionate about art. A great deal of his work was on display at the lending library. He is definitely a fan of super heroes, fantasy figures, and other colorful characters.
"Because his disability affects muscle strength and movement, Christopher has been unable to hold a pencil or turn pages in a textbook since the seventh grade," Tapie said. "However, his disability never held him back in terms of educational progress. It is his character and curiosity that have enabled him to achieve academic success as he works to complete his course credits for graduation. Technology has certainly provided a foundation on which he has been able to do so."
Christopher was named as the winner of the "Yes, I Can" Award in Technology by the Council for Exceptional Children in April 2015. He was more recently awarded the Every Child Succeeding Award from the Association of California School Administrators (ACSA) and will be honored at a ceremony in May 2016.
"It is his artistic talent and his willingness to embrace technology has resulted in this important honor," Tapie said. "And now thanks to a robotic device, the reciprocal experience of creating, critiquing and enhancing artistic expression between Christopher and his classmates has provided an extension of opportunities for him to grow as an artist, and also support the growth of his peers in their work."
Christopher is among about a dozen students in L.A. Unified who are able to participate in general education classes thanks to the use of VGo technology.
Other devices on display at the lending library used technology called Eyegaze, which use eye movements to manipulate keyboards and other input devices.
"It is important to be able to spend time with each student and know what specific barriers he or she faces," said Brian Saavedra, an occupational therapist who specializes in finding the right assistive technology for students. "It's one thing to read about or see images of these devices. But to appreciate fully how they function and help our students, one needs actually to interact with them in person the way our students do."
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Home | Companies
Tags: Howard Stern | Sirius XM | radio | video
Howard Stern Announces 5-year Deal With Sirius XM
Howard Stern (AP Photo/Richard Drew)
Cynthia Littleton Tuesday, 15 December 2015 10:06 AM
Howard Stern has struck a new five-year deal with SiriusXM Satellite Radio that includes plans for a streaming video component to augment his four-hour daily radio program.
The famed shock j0ck announced the agreement live on his show Tuesday morning. Details of the video plan were not immediately clear but SiriusXM said the pact includes a 12-year deal giving SiriusXM rights to video and audio material from Stern's 30-year radio career and a plan "to launch its first venture into video programming with Howard."
Stern also has a separate pact with Lloyd Braun's Whalerock Industries to create an Internet hub for all things Stern — a deal that lead to speculation that the radio veteran would pursue a direct-to-consumer option if SiriusXM balked at a rich renewal deal. But SiriusXM's emphasis on the video component and long-term library rights in the new pact would seem to limit Stern's ability to launch much of an online service.
Stern referred to a streaming video service in talking up the deal and expressing his affection for SiriusXM CEO Jim Meyer.
"I am living a dream here on satellite radio and Jim Meyer is my life partner and the baby we are about to have is our new streaming video app," he said.
After some tough talk from Stern, who teased listeners on Monday that Wednesday might mark his last show, the star hailed the new deal in his own inimitable way.
"As a broadcaster, it does not get any better than working at SiriusXM and I'm truly excited for the future with this great company. I happen to think that its best days are ahead," Stern said.
"So, if you are not listening to SiriusXM and 'The Howard Stern Show,' then you are really more like a zombie, a rotting corpse monster, living half a life, deadened and blackened inside. It's as if you were still watching black and white television while shopping in actual stores on your way to the post office to fax a memo."
Stern has been the cornerstone of Sirius XM's service since 2004, prior to Sirius' merger with XM Satellite Radio. He signed his most recent five-year contract with the company in 2010. He has earned an estimated $80 million a year under that contract.
Negotiations went down to the wire, as Stern's contract formally expires at year's end but his last new show of 2015 is set for Wednesday.
Meyer made it clear in public statements during the past year that he hoped to keep Stern but not at a price that breaks the bank. Financial details of the new deal were not immediately available.
Stern's longtime agent, Don Buchwald, called it a "cutting edge and truly unique broadcasting agreement" that "required a lot of give and take, as well as creative thinking on everyone's part."
Earlier this year, Stern ended his four-season run as a judge on NBC's summer talent show "America's Got Talent."
Stern is credited with helping to build up SiriusXM's subscriber base to nearly 33 million in the U.S. and Canada. Today, seven out of every 10 new cars sold in North America come with a SiriusXM free trial, and Stern is known to be a major draw for users to sign up as paying customers.
© 2019 Thomson/Reuters. All rights reserved.
Howard Stern, Sirius XM, radio, video
Tuesday, 15 December 2015 10:06 AM
US Judge Slashes Roundup Jury Award to $25.3M from $80.3M
A federal judge on Monday slashed a damages award that Bayer AG owed a California man who blamed Roundup weed killer for . . .
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WSJ: Schwab in Talks to Buy USAA Wealth, Brokerage Units
Charles Schwab Corp. appears to be making a play to grab more advisory clients as fees fall for asset management and tra . . .


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Rights of children must trump violent parents: Rosie Batty
By Miki Perkins and Social Affairs
Updated September 28, 2015 — 5.40pm first published at 5.15pm
Luke Batty's parents were not together when he was born, but his mum Rosie was told it was very important a child have access to both parents.
Rosie Batty responds to the findings of the inquest into the death of her son, Luke. Credit:Eddie Jim
But custody visits with her volatile ex-partner Greg Anderson took an "unbearable" toll on her and Luke, Rosie Batty said on Monday, speaking after the release of the coroner's report into her son's murder.
"It seems to be that the perpetrators have rights that are not right for the child," she said.
A myth persists that men who abuse, assault, blackmail, stalk or terrorise their ex-partners can still be "good dads".
It's a cultural shibboleth that remains largely unexamined (and given copious oxygen by men's rights groups), yet often informs custody agreements.
"This notion you can be a great father and an abusive partner - it's not possible," says Professor Cathy Humphries, one of a handful of family violence experts who have supported Ms Batty through the harrowing coronial process.
Luke suffered, and began counselling because he was distressed by contact with his volatile father, who he loved.
In Ms Batty's case, her good relationship with Luke meant child protection deemed her a "protective parent" and closed the case.
But not before workers insisted Ms Batty sign an undertaking she would make sure Anderson didn't take photos of their son, and his access to Luke would be supervised.
What kind of a system makes women take responsibility for their violent partners' behaviour?
In his report, Coroner Ian Gray recommends an approach that puts the welfare of children - and that of their mothers - first.
Where one parent is assessed as "protective", they should be given support by the Department of Human Services to manage the risk posed by the other parent, he writes.
Similarly, the department should end its practice of asking women to supervise or manage the behaviour of the other parent.
Judge Gray also makes recommendations about how child protection workers should respond to family violence - some seem so obvious, it is sobering they must be made at all.
For example, when assessing the risk to a child, workers should find out if their parents have any family violence notifications with the police or relevant domestic violence organisations.
Because intervention orders can be varied to allow for custody arrangements, there continue to be many women who have to negotiate with their former abuser, including - as Ms Batty noted yesterday - arranging for their children to visit the perpetrator in prison.
"We know that what is best for the child has to be paramount, and right now [we privilege] what the parents want to fulfil their own needs," she said.
Miki Perkins
Miki Perkins is a senior journalist and Social Affairs Editor at The Age.


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Which Country Is Best For Studying Architecture?
What is the highest degree in architecture?
What university is known for architecture?
Will architects be replaced by robots?
Where do most architects live?
Which country is famous for architecture study?
What is the best architecture school in the world?
Why are architects poor?
Which country pays architects most?
What is the highest paying job in architecture?
Can architects make millions?
Who is the richest man in history?
Is architecture hard to study?
What skills do you need to be an architect?
Where are architects best paid?
Are architects happy?
Do architects travel a lot?
Is architecture a good career?
Are architects rich?
Who is the richest architect?
Master of ArchitectureThe Master of Architecture (M.
Arch.) is a professional degree in architecture, qualifying the graduate to move through the various stages of professional accreditation (internship, exams) that result in receiving a license..
The Top 10 Architecture Graduate Programs1Harvard University2Columbia University3Massachusetts Institute of Technology (M.I.T.)4Cornell University5Yale University5 more rows•Sep 4, 2018
Automation and artificial intelligence, for the time being, would not replace architects, but this does not mean that the discipline does not undergo profound transformations in its exercise: computers and software eliminate tedious repetitive activities, optimizing the production of technical material and allowing, …
San Francisco, California. Here some stats on the State of California: … New York City, NY. New York was ranked as the third-highest paying city behind Santa Rosa. … Seattle, Washington. Washington is among the top 10 states for architects. … Boston, Massachusetts. … Dallas, TX.
Countries like the USA, Canada, Russia, Germany, China, Japan, Greece, Germany, England, etc. are countries that offer good courses in Architecture.
These are the top 20 architecture schools in the world.Manchester School of Architecture (MSA) … Politecnico di Milano. … University of California, Berkeley (UCB) … Harvard University. … ETH Zurich. … University College London (UCL) … Delft University of Technology. … Massachusetts Institute of Technology (MIT) Location: Cambridge, US.More items…•
Architects consider themselves poor because they always compare themselves to other white collar professionals like lawyers, doctors, and bankers who generally make more money. … And what does that mean "you can make money in this profession if you want to.
An infographic published by Metalocus shows that these seven countries (in ascending order) offer highest average monthly salaries: Ireland ($4,651), Qatar ($4,665), Canada ($4,745), Australia ($4,750), United States ($5,918), the UK ($6,146), and Switzerland ($7,374).
Top 5 Best Paying Related Architect Jobs in the U.S.Job TitleAnnual SalaryMonthly PayPrincipal Solutions Architect$167,500$13,958Remote Solutions Architect$163,999$13,667Chief Software Architect$162,857$13,571IT Data Architect$159,443$13,2871 more row
Most architects spend years in school, go through an internship and earn far less. And yet what we do as architects is just as needed. The average salary of a sole proprietor in the US is $70,000 according to recent surveys. … The good news is, making a great income IS possible for an architect.
Mansa Musa I of MaliAt an estimated value of $400 billion, Mansa Musa I of Mali is the richest person who ever lived. Born in 1280, Mansa Musa was ruler of the Malian empire, and acquired the most part of his wealth from the production and trade of salt and gold; more than half of the world's supply at the time in fact.
Doing an architecture degree can be hugely rewarding. But it is also among the most challenging – with long hours, a huge workload and focus on detail – so it's vital to understand what you're letting yourself in for. Here we answer students' commonly asked questions.
Skills and knowledgedesign skills and knowledge.knowledge of building and construction.to be thorough and pay attention to detail.thinking and reasoning skills.customer service skills.excellent verbal communication skills.analytical thinking skills.the ability to use your initiative.More items…
Best-Paying States for Architects The states and districts that pay Architects the highest mean salary are New York ($106,910), District of Columbia ($105,380), Georgia ($104,470), Massachusetts ($102,320), and Minnesota ($99,870).
Architects are about average in terms of happiness. At CareerExplorer, we conduct an ongoing survey with millions of people and ask them how satisfied they are with their careers. As it turns out, architects rate their career happiness 3.1 out of 5 stars which puts them in the bottom 41% of careers.
Architects who work for international companies will often travel to different locations all the time in order to design and complete a project.
Architecture is rough. It's definitely not a profession for everyone or more accurately everyone who thinks they should be an Architect. In fact, architecture can be more of a lifestyle than just a job or a profession. Unfortunately in many situations the cards often aren't stacked in the Architects favor.
Technically, at least in the US, architects are "rich." An upper-level manager, a partner or a principal generally make more than about 95-98% of the U.S. It's also sort of the same way how people believe those working in the tech industry or engineering believe them to be well off.
Norman FosterWho is the richest architect? Today, the highest earning architect in the world is 77-year-old Norman Foster of Foster and Partners.
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Breakthroughs in childhood cancer
A new clinical trial takes CAR T-cell therapy to the next level
For the past two years, Children's Wisconsin has offered cutting edge therapies that harness a patient's own immune system to fight cancer. Children's is one of only about 40 pediatric hospitals in the country authorized to treat patients with relapsed or refractory B-cell acute lymphoblastic leukemia (ALL) using CAR T-cell immunotherapy Kymriah™ (tisagenlecleucel). While Kymriah uses a CD19-directed genetically modified autologous T-cell immunotherapy to treat patients, clinicians and researchers at Children's and The Medical College of Wisconsin have now developed their own CAR T-cell product targeting both the CD19 and the CD20 antigens.
"The thought is that by targeting both the CD19 and CD20, instead of just the CD19 like Kymriah does, hopefully, there is less chance of cancer cells escaping the therapy and returning," says Julie An M. Talano, MD, a pediatric bone marrow transplant and cellular therapy physician at Children's and professor at the Medical College of Wisconsin, who leads the bone marrow transplant clinical research team at Children's.
Children's new clinical trial, which was approved and launched in the fall of 2020, is open to patients with refractory leukemia that have failed traditional therapy and commercial products. Patients must be relatively stable, have adequate heart, oxygen and kidney function, and be under the age of 39.
One of the chief challenges with Kymriah, which led to the development of this new treatment, is the 50% relapse rate. "It also takes several weeks to manufacture the cells (at Novartis)," Dr. Talano says. "And these children are fragile and often quite ill, so there's a very small window of opportunity to help them."
The cells for Children's new CD19 and CD20 trial will be manufactured locally using the Prodigy system in the lymphocyte propagation laboratory at the Medical College under the direction of Bryon Johnson, PhD, and Tyce Kearl MD, PhD. This on-site manufacturing has shortened the turnaround time for cells from four-to-six weeks down to two weeks, which is critical for fragile patients. Plus, in the midst of a global COVID-19 pandemic, being able to treat patients locally gives them and their loved ones one less thing to worry about, adds Dr. Talano.
"Not only is this an exciting development for us and our patients, but it was a huge undertaking by multiple people across this campus — and we've also partnered with local scientists who will be studying these samples to learn more about the immune system as well," Dr. Talano says. "These efforts position Children's on the cutting edge of cellular therapy treatments."
One of the greatest risks with any CAR T-cell immunotherapy treatment is cytokine release syndrome (CRS), in which the large, rapid release of cytokines into the blood from the modified immune cells leads to fever, nausea, headache, rash, rapid heartbeat, low blood pressure and respiratory problems. Neurologic side effects may also occur, including encephalopathy.
"We mandate that the patients be monitored very closely for 30 days after the cells are infused. And we closely monitor them throughout the trial," Dr. Talano says.
Dr. Talano and her team have also worked closely with the emergency room and intensive care unit staff to educate them about the treatment and the early signs of CRS and other complications.
For information and eligibility requirements on the CD19 and CD20 clinical trial, visit clinicaltrials.gov (CAR-20/19-T Cells in Pediatric and Young Adult Patients With Relapsed/Refractory B Cell ALL - Full Text View - ClinicalTrials.gov NCT04049383).