text:
Central Point Bank Robber In Custody
Metro Crime
August 20, 2021 2 min read MedfordAlert
On 8/20/21 at approximately 10:28 a.m., Central Point Police responded to the U.S. Bank in the 100 block of East Pine Street for a report of a bank robbery. The lone male suspect passed a note to the teller and purported to have a weapon, although no weapon was seen. After receiving an undisclosed amount of cash, the male fled on foot.
Dispatch was able to relay a suspect description and direction of travel to the responding Officers. Officers saturated the area and were able to locate a male matching the description several blocks away. The male fled on foot, but was later located hiding on private property. The male was taken into custody without incident.
Central Point Police K9 "Gus" was called in to assist in locating evidence potentially discarded over the multiple blocks traveled by the suspect. K9 "Gus" and his handler, Officer Aplin, were able to recover several articles of clothing discarded by the suspect, as well as all the cash taken from the bank.
The 33 year old male suspect was identified as Jeremy Justin Hetrick. He will be lodged in the Jackson County Jail on charges of: Robbery II, Theft I, Burglary II and Criminal Trespass II.
Central Point, Crime, Jackson County, Metro, Official Info, Rogue Valley
Amber Alert Issued
Metro AQ Advisory In Effect.
Portland Woman Arrested After High Speed Pursuit Involving Stolen BMW
JCSO Attempting to Locate White City Burglary Suspect
Medford Police Update on Search for November Bank Robber
Last Updated on Jan 31 2023, 1:53 am PST
Wind: West at 4mph


Dr. Sy was raised in Tucson, Arizona where he attended the University of Arizona on a full scholarship and graduated college in three years with a 4.0 GPA in physiology. He completed dental school at UCLA in 2009, earning numerous academic and leadership awards along the way. Upon graduation, he worked for one year for the Native American Tribal Health Center (completing an Advanced Education in General Dentistry-AEGD) before accepting a resident position at UCSF Oral and Maxillofacial Surgery. For the next six years, he trained in one of the premiere medical centers in the country where he received his medical degree (UC Davis), anesthesia, general surgery and maxillofacial surgery certification from UCSF. Dr. Sy has also been active in research and is the first author of two manuscripts in well-established, peer-reviewed journals.
Dr. Sy is of Chinese/Filipino descent, fluent in three languages including Tagalog and Taiwanese-Hokkien and is also conversational in Spanish. One of Dr. Sy's main interests is teaching and he frequently gives Continuing Education lectures on a broad range of topics from medical emergencies to cosmetics. His other interests include global outreach, travel and is a huge fan of bay area sports. He is married to his wife, Kippy, who is a general dentist in public health. They both continue to be active in their community and local charities.
Dr. Sy is skilled in all facets of oral and maxillofacial surgery and his scope includes dentoalveolar, implants, bone grafting, sinus lifts, office-based intravenous sedation, trauma, pathology, orthognathic surgery and non-surgical cosmetic alternatives such as Botox, Kybella, Latisse and dermal filler injections.


text:
University of Strathclyde joins major new net zero infrastructure programme
The University of Strathclyde's Centre for Energy Policy (CEP) has been named the lead academic partner in a new £30 million UK Government-funded initiative called Scotland's Net Zero Infrastructure (SNZI).
Part of Innovate UK's Industrial Strategy Challenge Fund, SNZI will bring together academic and industrial partners to develop a major package of work designed to progress a national low carbon infrastructure to support the transition of the Scottish and wider UK economies to net zero targets.
The programme has matched industry funding and links to the Acorn carbon capture and storage (CCS) project and will be led by Pale Blue Dot, a Storegga Group company and the lead project developer of the Acorn Project alongside Shell and Chrysaor. This will provide a significant boost to Scotland's fast-growing low carbon credentials, paving the way for onshore and offshore developments totalling more than £3 billion.
As the academic partner, CEP will lead work around understanding the longer-term economic impacts, including important job preservation and creation opportunities, as Scotland transitions away from oil and gas to low carbon fuels like hydrogen. There will be a particular focus on the role of carbon capture and storage (CCS) as both a large scale carbon dioxide (CO2) removal technology and a new industry opportunity.
Professor Karen Turner, director, Centre for Energy Policy, said: "Establishing a domestic CO2 management industry in Scotland could set important foundations for greener GDP generation, offsetting costs associated with industry decarbonisation, and sustaining existing and creating new jobs in the transitioning economy. An industry built around CCS in Scotland also brings potential for further growth through exporting C02 transport and storage services.
"However, realising this opportunity will involve responding to a range of associated economic and societal opportunities and challenges, including building understanding of the wider economy consequences of deploying CCS at scale.
"The Centre for Energy Policy has a solid track record of collaborating with industry and government partners to generate this type of critical evidence and analysis across various aspects of the net zero economy.
"We are looking forward to bringing this expertise to the SNZI programme and working with partners to ensure the project contributes to net sustained benefits at local, regional and national levels and accelerates progress towards mid-century net zero targets."
Other partners on the project include:
SSE Thermal, which is developing a comprehensive decarbonisation programme for Peterhead Power Station
National Grid, which is exploring the potential repurposing of onshore gas pipelines to transport CO2
Petrofac is supporting offshore pipeline and sub-surface activities to develop the Acorn CCS project
LNG9/GB-Tron will be undertaking an engineering design programme for carbon capture technology on a gas power station at Grangemouth
NECCUS is providing a key link to other work in Scotland, including the ISCF Plan and Scotland's Net Zero Roadmap project (SNZR).
The initiative complements work that is already underway on the SNZR, with CEP also contributing to the public policy understanding on that project.
University of Strathclyde unveils designs for £60m learning and teaching hub
University of Strathclyde announces first online CPD course for architects, planners and lighting designers
University of Strathclyde and ESALA dominate annual student architecture awards
University of Strathclyde's largest-ever gift to fund construction of new building

redpajama_set_name: RedPajamaCommonCrawl


Oooh, must listen to this tonight when i… | Something Odd!
I don't know if you watch The Russian Badger's vids, but he was on podcast #4. Very funny. You should watch a couple of his vids first though if you haven't already.


K&H Limburgse Katjes-- Cat Shaped Sweet Licorice 1kg - Licorice - The Dutch Shop LLC your store for Dutch groceries.
K&H Limburgse Katjes-- Cat Shaped Sweet Licorice 1kg. Ingredients: Sugar, glucose syrup, modified starch, gelatin, caramel coloring, licorice extract, ammonium chloride, artificial flavor, glazing agent (vegetable oil and beeswax).


how can people make money off poor people, is the big question.
But then, what we challenge students to do is to be able to question assumptions.
out of which 4 billion people earn less than $5 a day.
the big question in 2016, going forward, is what happened to the other 4 billion?
Why aren't for business companies actually targeting these people?
less than $5 a day, alleviate their poverty, and make money at the same time.
Or what we call ambidexterity.
Well, one of the key things that they have to do is be able to question assumptions.
is of low volume, but high margin, right?
high volume, 4 billion people, but very little margin from each person?
students to figure that out because of tradition, right?
work out what the lecturer's thinking, probably wrongly.
I'll give you an example, it's a very specific one.
I get the students to look up the student pronunciation, a second language learner.
It reasons why pronunciation is not correct.
English said, I watch TV yesterday, instead of watched.
I wanted a range of answers.
It could be because the student was tired.
It could be because they didn't hear the [SOUND] at the end.
It could be that they did know the past tense, but had difficulty pronouncing it.
So what we want often, is a range of possible answers.
not this is the answer but this could be this, it could be this, it could be this.
you're doing, giving yourself more time to do an essay, and thinking about it.


Brian Carter has designed nearly a dozen websites for himself and others, but more importantly, has brought more than half a million visitors to these sites since 1999- more than 20,000 per month in 2005, and, through various monetization strategies, this traffic has meant $5,000-20,000 monthly. Recently, he has devoted a limited number of hours per week to professional SEO expert consulting.
Achieving a high search engine ranking is indeed realistic. And that's something everyone with a website presence should be doing.
But it's not as simple as it sounds. Which search engines are most important to score well in? Which ones update most frequently? Which are most reliable?
And how many pages and keyphrases should you compete with? Just one? Five? Twenty?
Then there are your tactics- if it were possible to achieve high search engine rankings without thinking about how search engines rank sites, there would be no need for search engine optimization. But you do need to know how they think, because language is complicated, and programs (search engine ranking "bots") are dumb.
Still, you don't want to spam or cheat- not only because you'd anger the search engines, but also because your pages would begin to look weird to your human audience. So you need to know where the line is that separates ethical SEO from cheating.
What's worse, search engines can change their criteria for rankings without warning- so achieving a high search engine ranking means either constantly monitoring all the search engines and updating your pages, or taking a long-view, long-term smart approach based on how all search engines work and are likely to work in the future. From a cost and time investment perspective, the second choice is obviously better.
I provide Christian SEO services in that I am a Christian, and therefore my ethical practices are consistent with the Christian character I strive to have and improve upon.
Many Christians like to work with other Christians - they prefer to pay Christians for services- that may be because they see the alternative as being "unequally yoked" or because they just feel safer with someone whose conscience and decisions are informed by the Holy Spirit.
I gave my life to the lordship of Jesus Christ in 2001, and my wife (before we were married) followed me in 2002. I have several websites on Christian topics. I am eminently grateful (beyond my ability to express it) for the love of God.
I'm happy to work with anyone, regardless of their faith- though the projects and ideas I will lend my time, talents, and treasure to are informed by my conscience. Which is to say, for example, I will not do SEO for adult sites.
An ethical SEO firm (search engine optimization company) is committed to doing honest work that does not violate the terms of the major search engines. They keep abreast of SEO trends, are aware of what is considered search engine spam or gaming, and refuse to stoop to those tactics.
Ethical SEO firms are a positive force much like ethical marketers. Coming from a place of good character, clear conscience, and positive intentions, they help clients think about how to realize their business plans and marketing strategies in the online environment.
The Web is like the Wild West. Like that period of American History, the internet of the 90's and this first decade of the 21st century is a lawless Babylon replete with immoral tricksters. Search engines here are analogous to the law, and they are imperfect robot policemen always catching up to the latest expoits of unethical SEO marketers.
Ethical SEO techniques are sometimes called "white hat", and some ethical SEO experts become frustrated that leading search engines like Google, Yahoo, MSN, and Ask don't seem to be able to filter out the cheaters, but as an ethical SEO expert who takes the long view, I believe these genius SE engineers will figure it out, and those of us who do it the ethical way will be rewarded.
In search engine ranking, there is no guaranteed, and if anyone tells you there is, I suggest you run the other way, quick!
Even the best search engine ranking experts cannot ensure that every page of their websites gets top ranking. Search engines change their criteria, links to websites come and go, competition increases, specific tactics can be copied, etc.
What's more, each search engine has its own criteria for ranking, so your rankings will vary on each. It's possible for one of your pages to have a top five ranking on one engine, but be effectively invisible in another engine.
If you're looking for guaranteed search engine rankings, then you don't really understand search engine optimization. If an SEO firm offers guaranteed ranking, you'd better be sure their contract binds them to update their SEO work on your pages when search engines change their criteria. Otherwise, it's just a marketing gimmick on their part.
A guaranteed top 20 search engine ranking is certainly more realistic than a guaranteed top 10 search engine ranking. As I've said, nothing is certain in the search engine optimization world except change, and certain good long-term SEO strategies.
Your rankings on various pages and keyphrases will change like the weather from week to week, but ideally, the weather is generally good for your website because of the architecture your SEO expert has put into place.
Every keyphrase and industry is different. Even within the same industry, some keyphrases are more competitive, vulnerable, or glutted than others. Some are more profitable than others, some are more in line with your USP than others... intelligent SEO is an essential part of implementing a realistic business plan online.
But guaranteed search engine rankings are a suspect claim, or they must be written into your contract with the SEO firm.
Our butter loving bretheren in England still can't spell optimisation correctly, but we love them anyway. Just kidding! It's the same story regardless of what country you're in, but SEO experts may use different sources of data to find out what exactly people are searching for in whatever your target country is.
In 2005, despite great growth in the online presence of the Chinese, Africans, and South Americans, the major markets and dollars are still in the USA and English-focused internet. An SEO expert can focus your efforts whereever is needed.
Increasing your search engine ranking position is a much more realistic goal. Instead of focusing on perhaps unattainable perfection, you decide to be competitive in your industry and keyphrases.
A review of your niche, products, services, and target market will make it possible to unearth the most expeditious keyphrases to focus upon, and web page architecture based on time-tested and sensible SEO principles will ensure an increase in your search engine ranking position, web site traffic, and profits.
A good, ethical SEO firm will increase search engine ranking positions for all your most important keyphrases- at least as much as is possible in the current environment of flux and lawlessness.
Meta tag optimization is not fundamentally different from all search engine optimization (SEO). Meta tags are only one aspect of SEO, and meta tag optimization is possible only when the needed analysis of your business, goals, keyphrases, and competition is complete.
How much repetition will be tagged as spam- whether you intend to spam or not, you need to know when to stop!
As I've said, search engine ranking is different for each search engine. Yahoo, MSN, and Google, for example, all will rank pages differently, because they value different criteria.
To be more clear, they may all care about keyphrase usage in the same places on a page (title, headers, body, links), how many backlinks you have, what their link text says, etc. but they may assign different priorities to these criteria.
Various search engines also may have different maximum numbers of frequency and weight for usage before you trigger a "spam" threshhold. And all of this can change from month to month... in fact, with Google, it has been changing unpredictably for about a year!
MSN has been taking search much more seriously of late. They've been advertising it, improving their algorithms, and starting pay per click and profit-sharing publishing programs of their own. Obviously they are following in Google's footsteps and plan to compete in their typically vigorous fashion.
Lately, my own observations of how the big search engine services have ranking pages have increased my esteem for MSN rankings. Like Google, MSN actively indexes lots of pages, which helps you get SEO results quicker, but unlike Google, MSN has been more stable and predictable, which is good for both SEO and business. Google, on the other hand, has made life hard for even ethical SEO people- if traffic from Google is your lifeblood, you've probably suffered over the last year. They don't seem to understand that businesses require consistency to operate well, even to survive.
At first, I didn't welcome MSN's entry into search. But as Google continues to produce strange and unstable results about which now even normal search users are complaining, I am encouraged my MSN's search engine ranking techniques. No one has a crystal ball, but if MSN's way of doing business loudly and making big, slowly updated software is any measure, their aggressive pursuit of search market share bodes well for both SEO efforts and companies that want consistent search engine rankings.
Search Positioning SEO is rather redundant, I suppose, but when has redundancy ever stopped a good phrase from claiming mindshare?
Search engine optimization (SEO) means positioning web sites- or more specifically, web pages- high on search engines... and not just for any old phrase, but for keyphrases that real people are already typing into search engines, keyphrases that haven't already been vomited into a million other web pages.
But #1 is inefficient, #2 only works each time you do a mailing, which is expensive, besides which a % of your mailing list doesn't go online much, #3 is expensive and you keep having to pay for it over and over, and #4 isn't easy without a quality website... also, #4 happens naturally if you have high search engine rankings.
Elsewhere, I've answered a number of frequently asked questions about PPC vs. natural/organic search engine optimization rankings. The bottom line is that high search engine rankings will get you free traffic, thus more profit. But PPC is an important and powerful supplement to natural SEO. Both are ideal, but it would be foolish to do PPC without natural SEO. These days, ethical SEO is just part of how to do good web design.
All in One Web Site building and ranking solution: If you haven't started your web site yet, consider using Sitesell.com's Site Build It! all-in-one solution. I used it for my home-herbal-remedy.com website, and it works fine. It's nice for those with little html ability, but for us pro's it's a bit clunky- which explains why I haven't taken the time to make it look better. ;-) It's a great deal, well worth the money.
Web Position Gold 3 - $150-$350 depending on what you get, but an all in one tool with lots of great features.
If you're not sure if you want to invest in SEO expert consulting, I'd suggest you read the forums, and try the free WebCEO yourself. This will give you a much better sense about the real question, which is- do you want to deal with all that yourself?
People sometimes want a search engine rankings service from someone in their own city- despite the fact that the internet has changed all that so that you can get help from the best person anywhere.
I live in San Diego, and I'm happy to provide SEO services to San Diego companies who need search engine ranking help. Likewise, instead of writing a bunch of pages for other cities' searches, I respected the people of those cities- that they wanted someone local.
Of course, there are a number of San Diego SEO firms and SEO experts, and you don't have to choose me. In fact, I only have a limited number of hours to devote to SEO consultant work, because I run several other sites, write books, and teach medical classes at the Pacific College of Oriental Medicine.
This is what it's all about. High search engine rankings make you visible to real people who are already searching for the services, products, or information you offer. Without search engine optimization, high search engine rankings will elude you.
Of course, you could pay per click, become a "sponsored listing" and be visible up there... and statistics show that most searchers don't know the difference between a natural search engine result and a paid one... but your pocketbook and your accountant know the difference.
In a well run business, search engine optimization should be treated like any other marketing strategy. It should pay for itself at least, if not lead to profits and business you wouldn't have seen otherwise.
If you can get high search engine rankings with search engine optimization, you'll get long-term traffic, prospects, business, and so on from a one time investment. If you only do pay per click advertising, you'll keep paying and paying and paying. You can do both, but SEO natural rankings are not optional.
I'm developing a training course for aspiring SEO experts. Over the last six years, I've read up on all the techniques and strategies the experts have suggested, and I've done my own experiments as well.
My site pulsemed.org has more than 1,700 pages, at least 1,000 of which are keyphrase optimized pages. The website is a bit of a frankenstein, because I kept adding to it and changing strategies as I learned... but it remains a great resource for me to learn more and more about SEO.
So my SEO training course will be based both on the distillation of dozens of experts and ebooks, the thousands of SEO forum posts I've read, and my own in-the-trenches, scientist in the SEO laboratory experience... you'll learn from both my failures and successes.
As I've said about MSN and Google, every search engine is different, and they all will rank the same page differently. Maddening, I know... but it's better to have more than one brain trust working on this search engine problem- and their competition with one another will ensure that search improves, and search engine rankings ultimately will be higher quality.
If you're new to the internet, Yahoo used to be just a directory- hand-picked pages in categories. But they've added a search engine "web" directory as well.
Anyhow, a top Yahoo search engine ranking is a lot like an MSN one right now- they're the second and third top used engines behing Google. As of March 2, 2005, they each get about 60% as much traffic as Google. And it's important to note that 60-70% of searchers of all three of these search engines use other search engines.
The point is that each of the major search engines is a tool, and you should strive for as many top rankings in Google, Yahoo, and MSN as possible- your web site should be optimized for all of them.
You could certainly strive only for top MSN rankings, top Google rankings, or top Yahoo rankings, but there's no reason to... using ethical best practices SEO strategies, you'll get good rankings on all of them, but not top rankings for every page- that's just the nature of the beast.
It's a web in joke- and not a funny one- that web site designers will sell you on a great looking website that won't necessarily bring any visitors. Kevin Costner did not create the web, so if you build it, they might not come.
For example, some web site design people love Flash, but at this point, none of the search engines will rank a Flash page- all the text in the Flash is invisible to them. That's not to dis Flash, because it's great if used correctly.
Thus, more and more people realize that web site design must take your top search engine ranking goals into account. The best way to do it is to think SEO before you even build the web site!
Huh? How can you optimize something that doesn't exist?
You're right- you can't. But let's not get stuck on the words. The problem is, if you don't know anything about the web, and your web site designer doesn't know about SEO, he'll urge you toward cool looking stuff, and you'll think in terms of your business as it has been offline.
But online is different. Not totally different, but very different.
In a way, you have to go back to basics- no matter how many years you've been doing business, you have to think about your business plan, your goals, your unique competitive advantages, your target market, and so on. These all go into choosing the right keyphrases to dominate, and how you write the copy on the pages you create. Then you have a fighting chance of your web site getting top search engine rankings.
But if you already have a web site, you can still optimize it. We may have to change some things on some or all of your pages. We may have to create more pages.
And there may be other great options you haven't thought of or gotten the most out of, like an email mailing list... but that's another topic.


Most financial plans are designed or structured with an enormous amount of guesswork. Advisors are guessing about the rate of returns or guessing about the future needs of the clients. Going deeper, clients are even guessing about their future financial needs. How do you really know what you will need financially in the future to live? The 4% math equation does not tell the full story. People are working longer into retirement years and their qualified investment buckets have major losses with severe tax penalties due. For many of us, not only do spiritual, emotional, and physical needs change from year to year, but our financial needs do as well. This would be one of the most important needs that we must stay in step with.
We believe you should be highly aware of its presence in your life. It is a primary source for your lifestyle. We also believe that you should anticipate variables in life that will bring a disruption of cash flow to your life and build an ideal financial solution that keeps your cash heavy. The first step to make is protecting your current cash flow starting here.
An automated stream of money funding your plan. You have to systematically fund your plan.
A solid rate of return on your investment. Earnings must be solid.
Availability is paramount. You should not lock up your dollars in a way that there is no availability due to future needs.
Minimum taxes. Taxes are the name of the game. Hopefully, you want to pay as little taxes as possible.
Minimum tax distribution. In distribution, life is different, money is different, so taxes need to be low.
Easy distribution. Your wealth should be an easy transfer with minimum problems.
Minimize losses. Financial risk is detrimental. Do not play this game.
Contingency proof. Meaning, it is able to handle all unknown or unanticipated needs such as death, disabilities, etc.
Flexible. Your financial plan is flexible enough to connect with your greatest financial desires.
Consumer control. You keep 100% of control. No one else.
You should be educated well enough to implement a plan that satisfies all of these benefits without sacrificing one. The goal of your financial plan is to maximize your profits in the least expensive way while still enjoying life.


A short while ago my friend Tom - who traded bonds for many decades and knows something about debt -sent me an email that simplified the understanding of the federal debt problem. I'm guessing he thought it might end up on this blog.
The national debt, as it is sometimes called, is easily thought of as something the government owes, but we all owe the money. Unfortunately, for most people it's more of a concept than an actual problem. It's why they keep voting for people like Barack Obama and George W Bush. It's also why they haven't figured out that Mitt Gingrich won't be the correct answer to the question of how it's going to be addressed.
People have a hard time relating to numbers as astronomical as those the government owes. When the numbers become so big, billions and trillions start to run together into one big imaginary number. But remember folks, a brazillion isn't just a hair removal reference and Greece isn't just a place with goat soup and stinky cheese. If you take a good look while walking along on our national journey, you can see the end of the road that we have been kicking the can along for so long. And you don't have to squint anymore.
You can go back to sleep this election and hope the nightmare is gone when you wake up, but that hope will get you just about as far as the "hope and change" the nation bought into when a bunch of Democratic marketing slicksters sold it to them in 2008.
So how can we laugh while our money burns? It's easier if you use the tragicomedy video below as a teachable moment to make it clear just how ludicrous the debt has become as the politicians spend us into oblivion in order to buy our votes. I was laughing at the end of the video, but only because I know the joke is on us.
Feel free to pass the URL of this post around to your email list. This video should go viral.
"This rather brilliantly cuts thru all the political doublespeak we get. It puts it into a much better perspective."
Let's say, You come home from work and find there has been a sewer backup in your neighborhood....and your home has sewage all the way up to your ceilings.
Raise the ceilings, or pump out the crap?
Great piece. I will link to this from my Old Jarhead blog.
I'm glad you enjoyed it. And feel free to visit my blog at whatwethinkandwhy.blogspot.com where I post articles like this every time I come across them.
I'll be sure to visit your blog as well.


text:
using Grabacr07.KanColleWrapper.Models;
using MetroRadiance.Core;
using System;
using System.Collections;
using System.Collections.Generic;
using System.Linq;
using System.Windows;
using AMing.Plugins.Core.Extensions;
using forms = System.Windows.Forms;

namespace AMing.Warning.Views
{
    /// <summary>
    /// ToastWindow.xaml 的交互逻辑
    /// </summary>
    public partial class StatusWindow : Window
    {
        public StatusWindow()
        {
            InitializeComponent();
            this.Loaded += StatusWindow_Loaded;
            Application.Current.MainWindow.Closing += (sender, e) => this.Close();
            Application.Current.MainWindow.StateChanged += MainWindow_StateChanged;
        }

        void MainWindow_StateChanged(object sender, EventArgs e)
        {
            this.WindowState = Application.Current.MainWindow.WindowState;
        }

        void StatusWindow_Loaded(object sender, RoutedEventArgs e)
        {
            AMing.Plugins.Core.Helper.ToolWindowHelper.SetToolWindow(this);

            Dpi dpi = this.GetSystemDpi() ?? Dpi.Default;
            this.Top = forms.Screen.PrimaryScreen.WorkingArea.Height / dpi.ScaleY - this.Height;
            this.Left = forms.Screen.PrimaryScreen.WorkingArea.Width / dpi.ScaleX - this.Width;

            //AMing.Plugins.Core.Helper.PenetrateHelper.SetPenetrate(this);
            //this.Opacity = 0.8;
        }
        #region method

        private StatusItemControl AddShip(Ship ship)
        {
            var statusItemControl = new StatusItemControl(ship);
            sp_status.Children.Add(statusItemControl);

            return statusItemControl;
        }
        private void UpdateShip(StatusItemControl itemControl, Ship ship)
        {
            //itemControl.Fleet = fleet;
            itemControl.Ship = ship;
        }
        private void RemoveShip(Ship ship)
        {
            var itemControl = sp_status.Children.OfType<StatusItemControl>().FirstOrDefault(item => item.Ship.Id == ship.Id);
            if (null != itemControl)
            {
                itemControl.Remove();
            }
        }
        private void ClearShip()
        {
            sp_status.Children.OfType<StatusItemControl>().ToList().ForEach(item => item.Remove());
        }

        public void UpdateFleet(List<Ship> ships)
        {
            this.Dispatcher.BeginInvoke(new Action(() =>
            {
                List<Ship> showlist = new List<Ship>(ships);
                sp_status.Children.OfType<StatusItemControl>().ToList().ForEach(item =>
                {
                    var ship = showlist.FirstOrDefault(s => s.Id == item.Ship.Id);
                    if (ship != null)//存在就更新控件里面的信息,然后从队列中移除
                    {
                        UpdateShip(item, ship);
                        showlist.Remove(ship);
                    }
                    else
                    {
                        item.Remove();//如果已经不存在舰队里面就移除掉控件
                    }
                });
                showlist.ForEach(ship => AddShip(ship));//添加剩余的船

            }));
        }
        #endregion

    }
}

redpajama_set_name: RedPajamaGithub


text:
January 21, 2019 January 21, 2019 Gronda Morin
Deja Vu/ What Happened With The October 2013 Gov Shutdown That lasted 16 Days
PRESIDENT OBAMA SIGNING ACA INTO LAW
After the Democratic Party lawmakers in the US Congress under the Obama administration passed the 2010 Patient Protection and Affordable Care Act (Obamacare), the republican lawmakers attempted to repeal this legislation numerous times with no success. Conservative organizations challenged Obamacare in the courts to where they managed to have this law reviewed by the US Supreme Court in 2012 but the ruling was not in their favor."
"Then the conservatives pinned their hopes in winning the presidency in 2012, with the republican Mitt Romney, but no cigar. The Democratic Party incumbent President Barack Obama had thwarted their plans to kill Obamacare by winning a second term in the White House."
President Barack Obama and his wife Michelle are showered with confetti after his acceptance speech in Chicago, on November 7, 2012. # Reuters/Philip Andrews
Empty chairs at a GOP watch party in Las Vegas, on November 6, 2012. # AP Photo/Julie Jacobson
But in 2012, there were these Tea Party conservatives who managed to gain a bigger foothold in the House of Representatives within the US Congress to where their one mission was to end Obamacare. In 2013, they came up with the idea to attach a provision to a spending bill that would have eliminated the funding necessary for the continuation of Obamacare, and if their Democratic colleagues didn't sign off on this bill, there wouldn't be the monies to fund the running of the US government which would cause a government shutdown. After some back and forth maneuvering between the US Senate and the US House, it turned out that the US Congress had not passed the laws required to fund the US government beyond September 30, 2013. A government shutdown ensued which lasted 16 days.
What occurred in 2013 bears similarities to the government shutdown political currents of today, in January 2019. After years of GOP members telling their constituents that they could easily repeal Obamacare, they had to look like they were seriously working towards this goal. Meanwhile President Obama and democratic lawmakers were not about to allow their signature legislation crafted to grant accessible, affordable, quality health insurance to millions of previously uninsured Americans, to be gutted.
BOTH WERE INVOLVED WITH 2013 SHUTDOWN
As per a 10 /3/13 Forbes report, "right wing elements of the Republican Party — often referred to as the Tea Party — within the U.S. House of Representatives attached a provision to a spending bill that required eliminating funding for the implementation of the PPACA in order to fund the rest of the U.S. Federal Government."
"That bill was sent to the U.S. Senate. The Senate then stripped out the provisions relating to defunding the PPACA, and sent it back to the House. The House then sent back a version of the bill that delayed implementation of the Act for one year, and the Senate tabled the measure and didn't even take it up for consideration."
REP MICK MULVANEY WAS MAJOR PROPONENT OF 2013 SHUTDOWN/ IN 2019, HE'S PRESIDENT'S CHIEF OF STAFF
"Since the U.S. Congress has not passed law to appropriate any funds past September 30, 2013, the Federal Government has "shut down."
"Somewhat ironically, as of October 1, 2013, the health insurance exchanges created by the Act are now open for enrollment. Funding for those was already appropriated. http://www.healthcare.gov."
Around the 16th of October 2013, the US Congressional Republicans conceded defeat on in their bitter budget fight with President Obama over the new health care law as the House and Senate approved last-minute legislation ending a disruptive 16-day government shutdown and extending federal borrowing power to avert a financial default with potentially worldwide economic repercussions.
AS REP DESANTIS IN 2013, HE PUSHED FOR 2013 GOV SHUTDOWN
Here's the rest of the story…
On October 3, 2013, Jena McGregor of the Washington Post penned the following report, "Negotiation experts on how to end the shutdown"
"Anyone hoping for a quick and tidy shutdown fix following President Obama's meeting with House and Senate leaders at the White House was bound to be disappointed. Senate Majority Leader Harry Reid (D-Nev.) told reporters after the meeting late Wednesday that "we are locked in tight on Obamacare." Minority Leader Mitch McConnell (R-Ky.) called the meeting "cordial but unproductive."
CANTOR/ PELOSI/ BOEHNER/ OBAMA/ REID
"But as hours turn into days, the question everyone wants an answer to is just how the government shutdown might end. Will House Speaker John Boehner (R-Ohio) cave and allow a vote on a "clean" funding bill? Will the president or Democrats weaken their current stance on negotiating over Obamacare? How long will all this go on?"
"I asked negotiation experts to take out their crystal balls and explain, using what they know about conflict resolution, the kind of exit strategy that might be used to bring the shutdown to a conclusion. How would they advise the president or the Republicans? What have other stalemates taught us?"
OBAMA/ MCCONNELL/ GRASSLEY
"First, let's establish what kind of negotiation we're talking about here. Calling the shutdown an "impasse" or a "standoff" implies that both sides are equally responsible for the current crisis. Rather, there is a group of Republicans trying to work outside the normal legislative process to overturn a law, and the president is refusing to negotiate to prevent setting such a precedent. Still, the fact remains that "there is a power struggle going on," as William Ury, co-author of negotiation bible "Getting to Yes," said. The two sides have dug in, the little talk that is happening is caustic and ineffective, and the ideological principles dividing the groups aren't about to change overnight. "The question is how is this power struggle going to be resolved?"
"Most of the experts I spoke with agreed on 3 things:"
"This is likely to get worse before it gets better."
"The president might choose not to negotiate on his core principles, but he'll still have to find a way to let Republicans save face."
"And even if you're dealing with hostage-takers, there's still room to talk."
"Let's take these one by one. Right now, however bad the shutdown may be for many people, neither Democratic or Republican leaders yet feel immediate pain from the fallout. Democrats know the polls show that Republicans are getting hit worse by the government's closure. And Republicans aren't yet getting heat from constituents for their hardline positions. But at some point, a shutdown—or worse, the potential of a disastrous default—could become so painful that it drives people to the negotiating table."
"There's a term for this in the field of conflict resolution. It's called a "mutually hurting stalemate," and Robert Bordone, director of the Harvard Negotiation and Mediation Clinic and a professor at Harvard Law School, thinks that's where the shutdown fight is headed. "Until people actually feel the pain themselves, they are falling victim to psychological biases." They're able to convince themselves that "this might be hurting me, but it's hurting you more."
"Similarly, others think the only way the shutdown will get resolved is for enough constituents (not just lawmakers) to feel pain, or at least get angry, over the crisis. Robert Tobias, who teaches conflict resolution as part of his role as director of American University's Key Executive Leadership Programs, is reminded of the quick fix Congress managed after sequester cuts furloughed air traffic controllers, wreaking havoc on flight delays. Given that 2.8 million people visited the federal Web site on opening day, he thinks the Affordable Care Act may get enough early adopters to change the debate."
"But digging in their heels and waiting around for everyone to get mad enough isn't necessarily a strategy. Seth Freeman, a professor of negotiation and conflict management at Columbia University and NYU's Stern School of Business, says that "there's a distinction between engagement and agreement. The subtlety here is that when you contact the other side, there's a risk your constituents see you as going native." That's one problem with the current dynamic: Boehner reportedly won't go to the table alone with Obama after some in his party tried to depose him following his fiscal cliff negotiations with the president. And now that Obama has repeatedly said he won't negotiate over his health care law as part of the funding bill or debt ceiling crisis, even inviting the key players to talks may be seen by some as capitulation."
"At some point, however, the White House and Democrats will need to find a way for Republicans to "climb down out of this tree," says Robert Mnookin, the director of the Harvard Negotiation Research Project and the author of "Bargaining with the Devil: When to Negotiate, When to Fight." What might that golden bridge for retreat look like? Mnookin and others say there will have to be a commitment to passing a clean spending and debt ceiling bill, while simultaneously agreeing to a process that would take place afterwards to try to improve the Affordable Care Act. Note: That doesn't mean Obama should cut a deal on the health care law to get the current crisis resolved. Bordone admits that "as a negotiation person I actually agree that the Democrats, if they relent on this, it's the worst decision they can make strategically. It reinforces bad behavior."
"But he and others say the president could set up a process that would take place after the first 2 crises are resolved, and which could give Republicans an out. "In my field we talk about substantive issues and process issues," Bordone says. President Obama might say "I will as a matter of process agree to talk about substantive issues related to the health care law"—but only after the funding bill is passed and the debt ceiling is raised, Bordone suggests. In other words, set up a process, give it some teeth, and make a commitment."
"Mnookin agrees: "The obvious deal, if I were to make a prediction, is for there to be a clean budget and a clean extension done simultaneously with an agreement that there's going to be some bipartisan approach to improving the health care law. Nothing would be done to delay the implementation of Obamacare. … But there would be a commitment to a legislative process to rather promptly explore how the Affordable Care Act can be improved."
"He admits, though, that such a solution would be tricky. "How can Obama credibly commit to being flexible to considering changes?" Mnookin asks. "It's clear he's not going to make changes that are going to gut it." And that, of course, may very well not be enough for conservatives who have what conflict resolution types call a "expectation interest." After years of being told by lawmakers that Obamacare can be repealed, conservative Republicans have come to expect that it can and will happen. When such an expectation interest is established, says Bordone, "you've created a monster. It ties the negotiators hands at the negotiation table."
"Even when expectations are unreasonable, some real level of engagement—and listening—needs to happen. This is true whether you're dealing with crises in the Middle East, politicians or even hostages. Ury, who has trained hostage negotiation squads, helped to broker arms control deals and advised countries on ethnic wars, says the conventional wisdom that you don't negotiate with hostage-takers simply isn't true. Today, he says, law enforcement officials "don't say we don't negotiate. They go in in a very organized way with a swat team, and they start listening," he says. "They don't give in on key principles, they don't let the hostage taker go. But they'll say 'do you need a hot sandwich, do you want something to drink?' And maybe they allow them to get the message across."
Bussiness & Consumer News
former House Speaker John Boehner
former Senate Majority Leader Harry Reid
Jena McGregor
Tea Party conservatives
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The obscenity of these independently very wealthy people having the gall and the arrogance to play their stupid little games with ordinary peoples lives is an obscenity.
If by no other standard Trump and his cronies are moral criminals.
Too many of these rich peoples end up being like hoarders instead of being thrilled that they're in a position to where they can help others. I like this saying, To whom much is given, much is expected.
But that they should deliberately seek to harm others is unconscionable.
I agree Gronda, the very worse of god complexes


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Home / Regional Movies / I am young at heart and want to stay so: Usha Naik
I am young at heart and want to stay so: Usha Naik
Usha Naik doesn't let her age be a deterrent when she is taking up projects and is keen to do more experimental films
regional-movies Updated: Jul 28, 2018 19:31 IST
Anjali Shetty
Hindustan Times, Pune
Usha Naik doesn't let her age be a deterrent when she is taking up projects and is keen to do more experimental films(HTPHOTO)
Having started out as a background dancer and junior artiste, veteran actor Usha Naik has featured in over 250 films. Known for her impeccable dancing skills, Naik later went to be the lead in several films in her five-decade-long career. This year, the senior actor will be seen in Milind Ukey's Monsoon Football, which stars Sagarika Ghatge, Chitrashi Rawat, Vidya Malavade, Pritam Kagne and Delnaaz Irani.
Naik says that she has seen various phases of the Marathi film industry. From being known to make dramatic films to classics and the latest crop of unbearable trends, the veteran has seen it all. "Honestly, people started noticing my work after Ek Hazarachi Note (2014). Till then, they knew I was an actor and a great dancer. However, after this film they believed I could act 'well' (smiles)," she says.
Naik likes to be a part of films that are helmed by talented directors. Through her experience, she has seen that no matter how great a script is, if the director is not good enough, the film does terribly. "I have seen films where the director gave in to the actor's demands and ruined a perfect story. Hence, I pick a director and not a story," she says.
Talking about Monsoon Football, she says, "Milind (Ukey, director) is an excellent person with great skills. He is a director, who is true to his script. He is clear in his head, which helps in the long run for a film."
At 62, Naik shows no signs of stopping and wants to do as many experimental projects as she can. She adds, "I am young at heart and want to stay so. I do have health issues but I don't let that be a deterrent. I feel evergreen at heart."
Naik finds many similarities between herself and her character in Monsoon Football. The Half Ticket (2017) actor says, "I found a lot of resemblance between me and my character. She is eager to learn and experiment. She is strong and determined just like me. So, I enjoyed portraying a part of me on screen."
I have learnt a lot from theatre: Bhushan Pradhan
My web show took me back to my stage days: Yatin Karyekar
Telugu remake of Pink goes on floors, Pawan Kalyan starts shooting
Vijay Deverakonda's Fighter starts rolling, Karan Johar to present film
Box office: Ala Vaikuntapuramloo, Sarileru Neekevvaru strike gold
Prabhas resumes shooting for next film, shares update on Facebook
https://www.hindustantimes.com/regional-movies/i-am-young-at-heart-and-want-to-stay-so-usha-naik/story-1d7Vyumsked3N0Q754VCAK.html
https://www.hindustantimes.com/regional-movies/telugu-remake-of-pink-goes-on-floors-pawan-kalyan-starts-shooting-see-pics/story-nKZ5ksQzcVCmRFeZjaM5nI.html
https://www.hindustantimes.com/regional-movies/vijay-deverakonda-s-fighter-goes-on-floors-karan-johar-comes-on-board-as-presenter/story-vJawHPoC4kxmVSNBcmUc8L.html
https://www.hindustantimes.com/regional-movies/sankranti-telugu-releases-ala-vaikuntapuramloo-sarileru-neekevvaru-strike-gold-at-the-box-office/story-Bm8033vi57uLu8fTVHkqJK.html
https://www.hindustantimes.com/regional-movies/prabhas-resumes-shooting-for-next-film-prabhas-20-shares-update-on-facebook/story-jvgKeAuFG0J1FzJOzh61cO.html


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ECHA's dossier evaluation process covers compliance checks and the examination of testing proposals. By consulting the table below, you can find out whether ECHA has started to evaluate dossiers for a particular substance and follow the progress through the evaluation process.
The table below displays the type, scope and status of the assessment undertaken for a given dossier. The decision date and the non-confidential version of the decision are published shortly after the decision has been adopted.
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Identifiers of the substance: Name (as on the Dissemination website); EC/List number (European Community number / List number assigned by ECHA); CAS number (also called the Chemical Abstract Service Registry Number or CAS RN).
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Last updated 17 January 2020. Database contains 2968 unique substances/entries.
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Showing 1 - 100 of 5,077 results.
Substance name
EC / List no
(+)-tartaric acid
(+/-) trans-3,3-dimethyl-5-(2,2,3-trimethyl-cyclopent-3-en-1-yl)pent-4-en-2-ol
(1-hydroxyethylidene)bisphosphonic acid, sodium salt
(1-methylethyl)-1,1'-biphenyl
(1-methylethylidene)di-4,1-phenylene tetraphenyl diphosphate
Testing Proposal
(1R,2R)-1,3-Dihydroxy-1-(4-nitrophenyl)propyl-2-ammonium (1R, 5S)-5-(dimethylphenylsilyl)-2-(hydroxymethyl)cyclopent-2-ene-1-carboxylate
(1R,2S,5R)-5-methyl-2-(propan-2-yl)-N-[2-(pyridin-2-yl)ethyl]cyclohexanecarboxamide
(2-(2-hydroxyethoxy)ethyl) oxo(phenyl)acetate; reaction mass of: 2-(2-((oxo(phenyl)acetyl)oxy)ethoxy)ethyl oxo(phenyl)acetate
(2-methoxymethylethoxy)propanol
(2E)-2-benzylideneoctanal
(2E)-2-ethyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)but-2-en-1-ol
(3,4,5-trifluorophenyl)boronic acid
(3-(Formylamino)propyl)dimethylammonioacetate
(3-chloropropyl)diethoxymethylsilane
(3-chloropropyl)dimethoxymethylsilane
(3-chloropropyl)triethoxysilane
(3E)-2-chloro-3-(hydroxymethylene)cyclohexene-1-carbaldehyde
(3R,6R)-3,6-dimethyl-1,4-dioxane-2,5-dione
(3S-cis)-3,6-dimethyl-1,4-dioxane-2,5-dione
(5-ethyl-1,3-dioxan-5-yl)methyl acrylate
(carboxymethyl)dimethyl-3-[(1-oxododecyl)amino]propylammonium hydroxide
(chloromethyl)triethoxysilane
(E)-3-methyl-5-cyclopentadecen-1-one
(E)-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-buten-2-one
(E-E )-3,3'-(1,4-phenylenedimethylidene)bis(2-oxobornane-10-sulfonic acid)
(epoxyethyl)benzene
(ethoxymethoxy)cyclododecane
(octadecanoato-O)oxoaluminium
(phenylethyl)benzene
(R)-lactic acid
(R)-p-mentha-1,8-diene
(Reaction product of 4-[2-(4-hydroxyphenyl)propan-2-yl]phenol, 2-(2-hydroxyethylamino)ethanol and formaldehyde), propoxylated
(RS)-N-(3-ethoxypropyl)-2,4-dihydroxy-3,3-dimethylbutanamide
(S,S)-1,1,1,2,2,3,4,5,5,5-decafluoropentane; reaction mass of: (R,R)-1,1,1,2,2,3,4,5,5,5-decafluoropentane
(tetrapropenyl)succinic acid
(trans(trans))-4'-vinyl-4-(4-methylphenyl)bicyclohexyl
(xylenes and 4-ethylbenzene)sulfonic acids
(Z)-2-butene-1,4-diol
(Z)-cyclooctene
(Z)-docos-13-enamide
(Z)-hex-3-enyl acetate
(Z)-hex-3-enyl benzoate
(Z)-N-9-octadecenylpropane-1,3-diamine
(Z)-N-methyl-N-(1-oxo-9-octadecenyl)glycine
(Z)-N-octadec-9-enylhexadecan-1-amide
(Z)-N-octadecyldocos-13-enamide
(Z)-octadec-9-enylamine, C16-18-(even numbered, saturated and unsaturated)-alkylamines
1,1',1''-nitrilotripropan-2-ol
1,1'-(1,1,2,2-tetramethylethylene)dibenzene
1,1'-(1,1-dimethyl-3-methylene-1,3-propanediyl)bisbenzene
1,1'-(2,3-dimethylbutane-2,3-diyl)bis[4-(propan-2-yl)benzene]
1,1'-(ethane-1,2-diyl)bis[pentabromobenzene]
1,1'-(isopropylidene)bis[3,5-dibromo-4-(2,3-dibromopropoxy)benzene]
1,1'-(methylenedi-4,1-phenylene)bis(3-butylurea)
1,1'-(methylenedi-p-phenylene)bismaleimide
1,1'-(p-tolylimino)dipropan-2-ol
1,1'-[methylenebis(oxy)]dibutane
1,1'-dithiobis[hexahydro-2H-azepin-2-one]
1,1'-ethan-1,2-diylbisbenzene, brominated
1,1'-isopropylidenebis(p-phenyleneoxy)dipropan-2-ol
1,1'-Methylenebis(4-isocyanatobenzene) and its oligomeric reaction products with [(methylethylene)bis(oxy)]dipropanol
1,1'-Methylenebis(4-isocyanatobenzene) and oligomeric reaction products of 1,1'-methylenebis(4-isocyanatobenzene) and oxydipropanol
1,1,1,2,2,4,5,5,5-nonafluoro-4-(trifluoromethyl )-3-pentanone
1,1,1,2,3,3,3-heptafluoropropane
1,1,1,3,3,3-hexamethyldisilazane
Dossier evaluation


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What Tests Are Done For Parkinson's Disease
Parkinson's Vaccine Shows Positive Results
Q: Can The Stress Of The Covid
COVID-19 vaccine shows positive results in first phase of human trials
A: Stress can definitely increase PD symptoms. I have discussed the relationship between stress, anxiety and PD in general before, and COVID-19 has certainly created a very stressful environment for everyone. There can be stress related to contracting the virus as well as the anxiety and concern about returning to pre-pandemic activities now that life is starting to return to normal. The stress is being felt much more acutely by older adults and those with chronic medical issues, members of the population who have an increased risk of complications from COVID-19 infection. Many people with PD experience anxiety as a non-motor feature of their PD, and many are reporting that anxiety has increased since the pandemic began. To help minimize stress and normalize the current situation, be sure to establish daily routines, continue to exercise , and stay connected with family and friends in person if youre ready, or online or on the phone. Be patient with yourself and with others.
Question: How Worried Should We Be About Virus Variants Does That Level Of Worry Change If Weve Been Vaccinated
Dr Okun: Mutations are very common in coronaviruses. Sometimes the mutations are easier to treat and sometimes they're harder to treat. The vaccine is still active, but the longer we give the virus to continue to mutate the worse chance we have of beating this thing. This is why its important for us to get our vaccines, put our masks on and distance. If we don't do these things and we let this virus crawl back in, and keep mutating, eventually it could beat the vaccinations. That's why it's so important for us to continue masking even though we are vaccinating.
Plants As 'mini Protein Factories'
Founded in 1999, Quebec Citys Medicago is a pioneer of plant-derived therapeutics.
Its tech takes the idea of traditional vaccine manufacturing based on using eggs to produce viruses and instead uses living plants as the bioreactor that produces a protein particle that mimics the target virus.
The first step is to create the required protein particle and introduce it into a plant-specific bacterial vector. This is then taken up by plants which multiplies the vector. It takes just four to six days for the mini-factories to produce the Virus-Like-Particles compared to around six months for egg-based production .
While initial experiments had used alfalfa , today the company uses N. benthamiana plants: a relative of tobacco which has a weakened immune system meaning genetic material can be hosted rather than rejected by the plant.
Copyright – Unless otherwise stated all contents of this web site are © 2021 – William Reed Business Media Ltd – All Rights Reserved – Full details for the use of materials on this site can be found in the Terms & Conditions
Also Check: Parkinson's Disease Education Handout
Question: My Family Refuses To Get The Vaccine What Is The Best Argument I Can Use To Try To Convince Them To Get It
Dr Okun: We can convince more people to consider the vaccine by starting out on the right foot. We have to respect each others points of view.
It's OK for people to be scared it's OK to question whether the safety record is there. You should be doing that. We now know that people who are vaccinated very rarely die of COVID-19-related complications statistically close to zero. I think that's a powerful fact.
Almost everybody wants the information. If you can share the information with them and have a positive dialogue and respect their points of view, I think more people will come around to the vaccine, particularly as the safety record continues to evolve. Sharing with people that you respect their decision and that you are grateful to have a dialogue will take us farther in overcoming vaccine hesitancy than shouting and fighting.
What Are The Differences Between Available Vaccines
Dr. Okun: Moderna and Pfizer vaccines are distributed in the U.S. and in other countries, with 94 and 95 percent effectiveness. Both require two dosages and need to be stored at incredibly low temperatures the Pfizer vaccine requiring an even lower storage temperature than the Moderna vaccine making distribution and storage a challenge. These two vaccines belong to a new treatment approach called messenger RNA vaccines, which create a COVID-19 defense system.
Other vaccines are in development around the world and most work more like a traditional vaccine . They send instructions through DNA, teaching the immune system how to respond to COVID-19. There are several vaccines in early development, but these have the most available information:
OxfordAstraZeneca: distributed in the U.K. with ~70 percent effectiveness. It works in two dosages. The major benefit to this vaccine is that it can be stored at refrigerator temperatures. The vaccine may be more effective if a weakened first shot is followed a few weeks later by a standard dose.
Sinovac and Sinopharm: created in China with ~78-80 percent effectiveness using two dosages. There is limited data on these vaccines. Sinovac is currently in late-stage trials in other countries.
Sputnik V: distributed in Russia and works using two dosages. Early reports are of ~92 percent effectiveness. However, there is limited data on this vaccine.
You May Like: How To Tell The Difference Between Essential Tremor And Parkinson's
Regulatory Process Under Way With Health Canada Fda And Mhra
Medicago started a rolling review for the candidate in April with Health Canada and will now seek regulatory approval imminently.
It has also initiated the regulatory filing process for the vaccine with the US FDA and UK MHRA while preliminary discussions are underway with the WHO in preparation of a submission to the organization.
Medicago has also initiated Phase 1/2 trial in Japan where it plans to submit for regulatory approval in combination with the Phase 2/3 global study results next spring.
What Is Required To Induce A Good Immunomodulating Therapy
We know that CD4+CD25+Foxp3 regulatory T cells inhibit autoimmunity and protect against tissue injury, in the case of PD, against neuronal death caused by the aggregation of -syn. Thus the best therapy for the treatment of PD appears to be the one that approaches enhancing Treg cell functions to restore tolerance to -syn and thereby protect the neurons against the detrimental chronic inflammatory response mounted by the immune system as a response to -syn toxicity. Tolerance still remains a fundamental concept of modern immunology and one has to consider that the induction of Treg could be coupled to therapeutic IgG production. B cells can also influence the T cell response indirectly by modulating DCs and both effects are probably mediated by IL-10 production. Alternatively, B cells could be directly involved in the generation of Tregs: Mann, et al., found that B cell deficiency resulted in a delay in the emergence of Foxp3 expressing Treg cells and IL-10 in the CNS during EAE, but not in the periphery, and that reconstitution with wild type B cells resulted in disease recovery and normalized IL-10 and Foxp3 expression.
Read Also: Moringa And Parkinson's Disease
Parkinson's Treatment Shows Positive Results In Clinical Testing
by University of Florida
Researchers from the University of Florida and 14 additional medical centers reported results today in the online version of The Lancet Neurology journal indicating that deep brain stimulation also known as DBS is effective at improving motor symptoms and quality of life in patients with advanced Parkinson's disease.
The study, sponsored by St. Jude Medical Inc., tested the safety and effectiveness of a constant current DBS device developed by St. Jude Medical to manage the symptoms of Parkinson's disease. The device aimed to reduce tremors, improve the slowness of movement, decrease the motor disability of the disease and reduce involuntary movements called dyskinesia, which are a common side effect of Parkinson's drugs.
After treatment, analysis of 136 patient diaries revealed longer periods of effective symptom control known as "on time" without involuntary movements. "On time" for patients who received stimulation increased by an average of 4.27 hours compared with an increase of 1.77 hours in the group without stimulation. Patients also noted overall improvements in the quality of their daily activities, mobility, emotional state, social support and physical comfort.
Today's voltage-controlled DBS devices deliver pulses of current that vary slightly with surrounding tissue changes. The DBS devices tested in this study are intended to provide more accurate delivery and control of the electrical pulses.
Therapeutic Immunization Protects Dopaminergic Neurons In A Mouse Model Of Parkinson's Disease
WION Fineprint: Oxford COVID-19 vaccine early trail shows positive results
*Center for Neurovirology and Neurodegenerative Disorders and Departments of Pathology and Microbiology and **Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 Departments of §Neurology and ¶Pathology and Center for Neurobiology and Behavior, Columbia University, New York, NY 10032 and College of Pharmacy, Creighton University, Omaha, NE 68178
See allHide authors and affiliations
Read Also: Stabilizing Spoon For Parkinson's
Q: I Received The Covid
A: The vaccine is certainly able to cause short term side effects of fatigue, aches and even fever. There isnt extensive data yet on how it affects PD symptoms, just anecdotal data. For some people, PD symptoms are worse in the short term. This does not mean that your PD has progressed, and I would expect that you will return to your previous baseline in the next few days. I would talk with your neurologist about your worsened tremor as well.
Is It More Difficult To Recover From Covid
Stay up to date with Parkinson's and COVID-19 information at Parkinson.org/COVID19.
Dr. Okun: Data suggests that having Parkinsons means a more difficult COVID-19 recovery. Since this virus is still actively spreading, we are collecting tons of data on COVID-19 patients. A study from The Roy J. and Lucille A. Carver College of Medicine at the University of Iowa, a Parkinsons Foundation Center of Excellence, showed that people with Parkinsons who contracted COVID-19 had a 30 percent increased risk of mortality from the virus.
Also Check: Neural Transplantation For The Treatment Of Parkinson's Disease
What Are The Most Common Covid
Dr. Okun: We are just starting to get the information on clinical Parkinsons symptoms and COVID-19. One study in Milan, Italy, reported that motor and non-motor symptoms seemed to worsen with COVID-19, and that medication adjustments were required in a third of people with PD and COVID-19. Researchers hypothesized that the COVID-19 infection, the Parkinsons medications, and the immune system, together create a perfect storm to worsen Parkinsons symptoms. The most common symptoms encountered were urinary issues, fatigue, cognitive dysfunction and confusion. We are seeing many patients who survive COVID-19 and require that their PD medications be adjusted. Similarly, we are also finding that in the hospital, a neurologist with expertise in Parkinsons can help in decision making for those with COVID-19.
Affiris Michael J Fox Foundation Report Positive Results On Pd01a Parkinson's Vaccine
By Cyndi Root
AFFiRiS announced in a press release that a study on PD01A, a Parkinsons disease vaccine, has shown positive results. The research, sponsored by the Michael J. Fox Foundation for Parkinson's Research , met its primary endpoint as two different doses of PD01A were well tolerated and safe. AFFiRiS and MJFF intend to conduct a follow-up study in Vienna, Austria starting in September on the immunological and clinical effects of a boost vaccination, and then proceed to Phase II trials.
Walter Schmidt, PhD, Co-founder and CEO of AFFiRiS, said, "The safety and tolerability observed in this study, especially in a protein such as alpha-synuclein where we do not yet know its normal function, are encouraging. We are grateful for the continued support of The Michael J. Fox Foundation as we progress in clinical development."
AFFiRiS' proprietary therapeutic vaccine, PD01A, was evaluated in the AFF008 trial. PD01A is an immunotherapy vaccine against Parkinsons disease that targets the protein alpha-synuclein. The agent produces alpha-synuclein-specific antibodies that are measurable in serum samples and cerebrospinal fluid. MJFF CEO Todd Sherer, PhD., said of the study results, "A treatment that could slow or stop Parkinsons progression would be a game changer for the five million worldwide living with this disease and the many more who will become at risk as our population ages.
About AFFiRiS
Also Check: Parkinson's Disease And Death
Ac Immune Announces Strategic Acquisition Of Industry
All stock acquisition & PIPE maintains and enhances AC Immune's strong cash position.
ACIU moves to the forefront of Parkinson's drug development
All-stock transaction maintains AC Immunes strong cash position
USD 25 million private placement led by premier investor Athos Service GmbH
Transactions expand and accelerate AC Immunes therapeutic development in Parkinsons disease
AC Immune to immediately launch clinical development of acquired vaccineinto an adaptive, biomarker-based Phase 2 study in Parkinsons disease
Conference call scheduled today at 8:30 am ET / 2:30 pm CET
LAUSANNE, Switzerland, July 27, 2021 — AC Immune SA , a clinical-stage biopharmaceutical company pioneering precision medicine for neurodegenerative diseases, today announced that it is acquiring Affiris portfolio of therapeutics targeting alpha-synuclein , notably Affiris PD01, a clinically-validated active vaccine candidate for the treatment of Parkinsons disease, as well as cash. The all-stock asset acquisition is valued at USD 58.7 million. AC Immunes cash position, as well as the Companys investor base, is also being strengthened by a total of USD 30 million in gross proceeds stemming from the asset acquisition and a parallel financing that are adding Athos Service GmbH , First Capital Partner GmbH 1 and MIG Fonds2, the lead investors in Covid-19 vaccine innovator BioNTech SE, as new AC Immune shareholders.
Figures accompanying this announcement are available at:
Immunotherapeutic Strategies For Pd
During the last decade the study of the access of immune cells, such T-cells, into the CNS has been extensively developed . Pioneering work from several researchers is now being exploited to design novel therapies aiming at T-cells for the treatment of neurodegenerative diseases
The current PD immunoregulatory therapies based on vaccine design can be divided into 2 strategies: One is based on generating antibodies against -syn,,, and the other one aims at the induction of a particular T cell response to modulate the neuroinflammatory response.,,,,- The first strategy has as primary goal the removal of -syn aggregates, as it is has been shown that this will modify the course of the disease.,, The second strategy targets microglia, as neuroinflammation has long been recognized to exacerbate the disease . A summary of all the recently designed immunotherapies used in experimental animal PD models is presented in .
Table 3. Immunotherapeutical strategies used in PD animal models
Abbreviations: DA, dopamine -syn, -synuclein DAT, dopamine transporter SN, Substantia nigra Tg, transgenic Ab, antibodies ko, knock out VIP, vasoactive intestinal peptide GM-CSF, Granulocyte macrophage colony stimulating factor TH, Thyrosin Hydroxylasa N.A., not applicable.
Read Also: Foods Not To Eat With Parkinson's Disease
Question: The Parkinsons Foundation Recently Posted A Covid
Dr. Okun: The highest COVID-19 mortality rates are among the elderly, so many countries including the United States, Europe and the Netherlands have prioritized vaccinations in people over 65. Many of the elderly population reside in nursing homes. The vaccine makes a lot of sense for most cases of elderly people and for people at nursing homes.
The Dutch study is specifically referring to handful of rare exceptions extremely frail or terminally ill people, or those who dont want their lives prolonged. There are also a group of people who cannot consent due to memory loss and dementia.
Its important to talk to your doctor. Its also important to have the conversation: What do you think this person would want us to do if they had capacity to consent? If the goal is prolonging life and preventing COVID-19, the vaccination might be the answer. For people who are terminally ill, very frail and at the end of life, you could make an argument that you should talk about it before administering a vaccine that could prolong their life.
What Do People With Parkinsons Need To Bring With Them For Their Vaccine Appointment
Moderna COVID-19 vaccine shows positive early results
Dr. Okun: Take your personal information and medication list. If you are prone to fainting, let the nurse know. For the second shot, bring the card issued to you on the first shot, so that the vaccine administration can be documented. Take a picture of the card once you have both shots so that you always have a copy.
Recommended Reading: Is Blurred Vision A Symptom Of Parkinson's
Question: When Should I Get The Vaccine If I Tested Positive For Covid
Dr. Okun: We don't have the exact answer to that question, but we're starting to get some clarity. If you had COVID-19 you should still be vaccinated. The Centers for Disease Control is looking at this question. We dont know how long its safe to not be vaccinated after youve recovered from COVID-19 or how long does the protection last. We are assessing whether an unvaccinated previously affected person can be with someone who's vaccinated and for how long they may get protection from having had the actual COVID-19 virus.
We have seen people with COVID-19 infection who do not have antibodies a few months down the road. The CDC is examining this issue but in general we recommend that people with Parkinsons who had COVID-19 get vaccinated 6-8 weeks after the infection. This may change with more guidance from the CDC.
Things are evolving quickly in the field and we want to make sure that we get you as much information as we can in-real time, so be sure to frequently check Parkinson.org/COVID19 for updates on the COVID-19 vaccination.
April 2020 World Parkinsons Day: Affiris Developing Pd01 To Treat Parkinson's Disease A Major Unmet Medical Need
World Parkinsons Day: AFFiRiS developing PD01 to treat Parkinsons disease, a major unmet medical need
Vienna, Austria, April 9, 2020 AFFiRiS, a clinical-stage biotechnology company developing novel disease-modifying specific active immunotherapies for patients with neurodegenerative diseases, joins people around the world to raise awareness of Parkinsons disease and the need to increase the efforts in the development of innovative treatment options.
Parkinsons disease is a neurodegenerative disease that results from a progressive loss of nerve cells in the brain. A diagnosis of PD is life-changing for patients, as increasingly debilitating and distressing problems with movement and mental function can develop. As the disease progresses, patients may require assistance for most activities of daily living, which places a profound emotional and physical strain on family members. An estimated 710 million people worldwide live with Parkinsons disease.
James Parkinson first described the disease in 1817 as the Shaking Palsy. Since 1997, World Parkinsons Day has been recognized annually on Parkinsons birthday, April 11th, and April has been designated as Parkinsons Awareness Month.
Currently available treatments aim to control the symptoms, not stop or reverse disease progression. Parkinsons disease as well as some other neurodegenerative disorders are characterized by the accumulation of the protein alpha-synuclein in neuronal or non-neuronal cells of the brain.
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The basic tasks of the University's academic advising program are to help advisees identify and achieve their academic goals, to promote intellectual discovery, to encourage students to take advantage of both in- and out-of-class educational opportunities, and to become self-directed learners and decision makers.
Academic advising specialists are available at each campus to help students; in addition, there is a full range of print and electronic advising resources for student use, including LionPath. The Advising Center can help with your advising questions.
Academic advising and course scheduling.
Assistance with selection of major, change of major, change of campus location.


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Brachycyttarus mixta is een vlinder uit de familie van de zakjesdragers (Psychidae). De wetenschappelijke naam van de soort is voor het eerst geldig gepubliceerd door Bourgogne.

Zakjesdragers

redpajama_set_name: RedPajamaWikipedia


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OPINION AND ANALYSIS | 27-01-2018 11:17
So what about policy for the forlorn and trashed forces?
And then there is the Army, the most politicised of the services. Historically a force able to remove governments at will. Recent available figures show a standing army of men and women and civilian staff of 80,000 soulds, with a not-veryimpressive list of 650 tanks, 850 pieces of heavy artillery and 150 helicopters.
Andrew Graham-Yooll
Former editor of the Buenos Aires Herald (1994-2007).
| Pablo Temes - CEDOC.
The passing of the second full month since the November 15 vanishing of the ARA San Juan submarine, with the third nonews month now in sight, leaves us with a catalogue of questions that go further than the immediate concern for the loss and bereavement of the families and friends of the 44 crew-members. These questions go to the quick of the Armed Forces, running to their budgets today, their symbol as a mechanism of national defence and the domestic politics that go into their management. Add to that the complex ways in which the Armed Forces are used across the political spectrum, by all parties.
Following information about allegedly faulty repairs on the ARA San Juan three years ago and the damaging effect of the loss of the submarine to society as a whole, the first stop in any inquiry should be the economies of the services and the way their monies are handled. This will obviously be extensive, involving the national border guard (Gendarmería), the coast guard (Prefectura), the National Police, the relatively new Air Security (Seguridad Aeroportuaria) founded in December 2010, the Federal Police with branches in all provinces, and the all-purpose so-called intelligence agency – formerly the Intelligence Secretariat (SIDE) founded on 4 June 1946, the day Juan Perón started his first presidency. SIDE has now closed to make way for the FI (Agencia Federal de Inteligencia), which created by Congress in February 2015. None of these agencies are seen with wholly friendly eyes in Argentina today.
A prime question, beyond the policy issues, is how society feels toward the military after nearly a century of change and upheaval. A comparative timeframe might start with the admiration expressed for the training of the Prussian Army in World War I by the Argentine Army and climax in the last military dictatorship (1976-83). Historically, it was the middle classes who liked the Navy (now a force of 18,500 men and women). This was in spite of or because of the anti-Peronism felt in the Navy, which climaxed in 1955 when the naval elite was primary in the action to bring down Perón. This is still a point of reference for many who wish to ventilate their prejudices against the naval institution as a whole. Social sentiment has its ups and downs, of course. This was in evidence with the outflow of sorrow and indignation when the ARA General Belgrano battleship was sunk by a British torpedo during the South Atlantic conflict in 1982, with the loss of 323 lives, more than half of Argentina's losses in the Malvinas War. The lost men were regarded as war heroes. The bloodiest regime in the 20th century was still in government.
The politics of security
A strong feeling of "hero status" toward the Navy came back once again with the more recent sinking of the San Juan submarine on November 15, about which there is hardly any evidence and much suspicion. The country was moved to great sorrow, eventually watered down by Argentina's persistent source of all evil: corruption. The suspicion of bribes and faulty repairs came to the surface in the first month after the sinking. Today, with little news in the search for the missing submarine, there are three technically equipped ships still involved on the high seas in the search for the submarine, two Argentine and one Russian.
The Argentine Air Force, with military members totalling 14,600 and 6,900 civilian personnel (figures dated in 2010) and what appears to be a limited number of flight units for transport and attack, had their greatest moment in the history of the service since its foundation in 1945 in the South Atlantic conflict. In fact, the Air Force emerged as the single successful fighting force during the 1982 war, mainly with the French-made Dassault-Breguet Super Etendard fighter jets, which first flew in 1974. These planes had been taken out of service, in Argentina and France, but last year it was confirmed that the government would contract the French builders for the modernisation of five Super-Etendards.
In popular terms, however, the Air Force is seen much as a technical force, a mystery service that attracts a class of servicemen interested in the mechanics and miracles of modern flying machines. It is obviously the smallest of the three services, seen in recent history as having less participation in the counter-insurgency activities of the 1970s.
A little less conversation, a little more action please
And then there is the Army, the most politicised of the services. Historically a force able to remove governments at will. Recent available figures show a standing army of men and women and civilian staff of 80,000 souls, with a not very impressive list of 650 tanks, 850 pieces of heavy artillery and 150 helicopters. Traditionally, the Army was a career-opening, especially for a lower middle and climbing class and one that actively thought in terms of NCO ranks opening the way to better social conditions, and also the paving of a path to university careers for their offspring. It lost much of its shine with the outrages of the 1970s.
The Army chiefs had secured presidential rulings under general Juan Carlos Onganía to court martial rioters in 1969 following the "Cordobazo." However, constitutionally the Army was barred from actions within national borders. It was in September 1975 when President María Estela Martinez (Isabelita) Perón signed a security law that authorised the "annihilation" of the ERP guerrillas in Tucumán and subversive elements elsewhere. The law gave the Army unlimited power, but eventually it would mark the beginning of the end of the idea of a "friendly army." In the 1980s, Argentina witnessed one of its most painful stages in history with the trials of the military leaders of the 1970s. Again, the country was torn apart. And it was not until the 1990s that the Army chief, general Martín Balza – who served eight years in the job, the longest term held by a commander – began the building of a professional army for men and women. The Army became a middle-class career setting once again.
The new government has taken cautious budgetary and professional steps towards a more efficient and useful Army. Whether or not this creates a new atmosphere in civilian-military relations is still very hard to guess.
(*) Former editor of the Buenos Aires Herald (1994-2007)
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The Simpsons is currently airing its thirtieth season on Fox. As one might expect, not all of the stories and characters covered over the span of three decades have gone over with fans, and there's been no backlash quite like that surrounding Apu Nahasapeemapetilon. The convenience store owner, voiced by Hank Azaria, has been the center of controversy. Many find him to be an inaccurate and even offensive portrayal of Indian-Americans in the U.S. Well, it now looks like The Simpsons is taking the drastic step of removing Apu.
I got some disheartening news back, that I've verified from multiple sources now: They're going to drop the Apu character altogether. They aren't going to make a big deal out of it, or anything like that, but they'll drop him altogether just to avoid the controversy.
Instead of attempting to remedy the problem and tweak Apu's characterization, Adi Shankar reports to Indiewire that Apu's elimination has been confirmed, if not officially announced by The Simpsons or Fox. His comments that the producers aren't going to make a big deal out of dropping Apu at least make it likely that Apu won't be killed off a la Maude Flanders. That said, Maude was killed due to a dispute with the voice actress, and Hank Azaria certainly isn't going anywhere.
The Simpsons' attempted to address the controversy that largely arose after the release of a documentary called The Problem With Apu that highlighted what many found offensive about the character, but it wasn't effective in stopping any backlash. Hank Azaria himself spoke up with an idea of how The Simpsons should change now that his "eyes have been opened."
If you are a show about cultural commentary and you are too afraid to comment on the culture, especially when it's a component of the culture you had a hand in creating, then you are a show about cowardice. It's not a step forward, or step backwards, it's just a massive step sideways. After having read all these wonderful scripts, I feel like sidestepping this issue doesn't solve it when the whole purpose of art, I would argue, is to bring us together.
The original goal for Adi Shankar's script contest was for Fox to produce the winning script for the show. Shankar has found what he considers the "perfect" script to do justice to Apu; the apparent removal of the character makes the production of the script as a canon episode of The Simpsons unlikely. In the winning script, Apu becomes a thriving businessman, moving on from his status as owner of a single convenience store.
Apu's absence from The Simpsons moving forward doesn't mean the script will never be produced, however. Adi Shanker is working to produce the script through his YouTube page, Bootleg Universe. We'll have to wait and see if and when this Apu script makes it to the small screen.
If you're still a Simpsons fans, you can catch new episodes of the series on Sundays at 8 p.m. ET on Fox. There are plenty of other viewing options, and you can find them on our fall TV premiere schedule.


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View the basic ALT,CODES,LIST,OF,KEY option chain and compare options of Altimmune, Inc. on Yahoo Finance. up-to-date news, portfolio management resources, international market data, social interaction and mortgage rates that help you manage your financial life. Search for ticker symbols for Stocks, Mutual Funds, ETFs, Indices and Futures on Yahoo! Finance.
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