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ADS8684 ADC Datasheet
ADS8684 Datasheet, PDF, Equivalent
SAR ADC
Datasheet Download ADS8684 Datasheet
Sample &
ADS8684, ADS8688
SBAS582C – JULY 2014 – REVISED APRIL 2015
ADS868x 16-Bit, 500-kSPS, 4- and 8-Channel, Single-Supply, SAR ADCs with
Bipolar Input Ranges
•1 16-Bit ADCs with Integrated Analog Front-End
• 4-, 8-Channel MUX with Auto and Manual Scan
• Channel-Independent Programmable Input
Ranges:
– Bipolar: ±10.24 V, ±5.12 V, ±2.56 V
– Unipolar: 10.24 V, 5.12 V
• 5-V Analog Supply: 1.65-V to 5-V I/O Supply
• Constant Resistive Input Impedance: 1 MΩ
• Input Overvoltage Protection: Up to ±20 V
• On-Chip, 4.096-V Reference with Low Drift
• Excellent Performance:
– 500-kSPS Aggregate Throughput
– DNL: ±0.5 LSB; INL: ±0.75 LSB
– Low Drift for Gain Error and Offset
– SNR: 92 dB; THD: –102 dB
– Low Power: 65 mW
• AUX Input → Direct Connection to ADC Inputs
• SPI™-Compatible Interface with Daisy-Chain
• Industrial Temperature Range: –40°C to 125°C
• TSSOP-38 Package (9.7 mm × 4.4 mm)
Simplified Block Diagram
1 M:
AIN_0P
AIN_0GND
AUX_IN
AUX_GND
AVDD
DVDD
2nd-Order
REFSEL
RST / PD
4.096V
REFCAP
REFIO
AGND
DGND
REFGND
• Power Automation
• Protection Relays
• PLC Analog Input Modules
The ADS8684 and ADS8688 are 4- and 8-channel,
integrated data acquisition systems based on a 16-bit
successive approximation (SAR) analog-to-digital
converter (ADC), operating at a throughput of
500-kSPS. The devices feature integrated analog
front-end circuitry for each input channel with
overvoltage protection up to ±20 V, a 4- or 8-channel
multiplexer with automatic and manual scanning
modes, and an on-chip, 4.096-V reference with low
temperature drift. Operating on a single 5-V analog
supply, each input channel on the devices can
support true bipolar input ranges of ±10.24 V,
±5.12 V, and ±2.56 V, as well as unipolar input
ranges of 0 V to 10.24 V and 0 V to 5.12 V. The gain
of the analog front-end for all input ranges is
accurately trimmed to ensure a high dc precision. The
input range selection is software-programmable and
independent for each channel. The devices offer a
1-MΩ constant resistive input impedance irrespective
of the selected input range.
The ADS8684 and ADS8688 offer a simple SPI-
compatible serial interface to the digital host and also
support daisy-chaining of multiple devices. The digital
supply operates from 1.65 V to 5.25 V, enabling
direct interface to a wide range of host controllers.
ADS868x
(1) For all available packages, see the orderable addendum at
the end of the datasheet.
Gain Error versus Temperature
----- ± 2.5*VREF
----- ± 1.25*VREF
----- ± 0.625*VREF
------ +2.5*VREF
------+1.25*VREF
±7 26 59 92
Free-Air Temperature (oC)
intellectual property matters and other important disclaimers. PRODUCTION DATA.
5 Device Comparison Table..................................... 4
7.4 Thermal Information .................................................. 6
7.5 Electrical Characteristics........................................... 7
7.6 Timing Requirements: Serial Interface.................... 11
7.7 Typical Characteristics ............................................ 12
8.5 Register Maps ......................................................... 45
10 Power-Supply Recommendations ..................... 57
12.1 Documentation Support ........................................ 59
Changes from Revision B (August 2014) to Revision C
• Changed unipolar sub-bullet of third Features bullet.............................................................................................................. 1
• Added title to page 1 block diagram ...................................................................................................................................... 1
• Deleted footnote from Device Comparison table ................................................................................................................... 4
• Updated ESD Ratings table to current standards ................................................................................................................. 6
• Corrected package name in Thermal Information table ........................................................................................................ 6
• Changed Auxiliary Channel, SINAD and SFDR typical specifications in Electrical Characteristics table ............................. 9
• Changed tDZ_CSDO symbol in Timing Requirements table and Figure 1................................................................................ 11
• Deleted clamp from second sentence of Overview section ................................................................................................ 21
• Changed voltage range values in second paragraph of Analog Inputs section .................................................................. 22
• Changed Range_CHn[2:0] to Range_CHn[3:0] in Programmable Gain Amplifier (PGA) section........................................ 25
• Added Bit 3 column to Table 3 ............................................................................................................................................ 25
• Changed SDO to SDI in second sentence of Event 3 in Data Acquisition Example section .............................................. 34
• Changed Continued Operation in the Selected Mode section ............................................................................................. 37
• Changed Frame Abort Condition section ............................................................................................................................. 38
• Changed STANDBY Mode section: added clarification to description of STANDBY mode................................................. 38
• Changed second paragraph of Power-Down Mode section: added clarification to description of PWR_DN mode ........... 40
• Changed first two paragraphs of Auto Channel Enable with Reset section......................................................................... 41
• Changed first paragraph of Manual Channel n Select section ............................................................................................ 42
• Changed second paragraph of Reset Program Registers section: added clarity to description of RST mode .................. 44
• Changed Program Register Description section ................................................................................................................. 45
• Made changes to product preview data sheet, released to Production Data......................................................................... 1
Product Folder Links: ADS8684 ADS8688
Features Product Folder Sample & Buy Technical Documents Tools & Software Support & Community Reference Design ADS8684, A DS8688 SBAS582C – JULY 2014 – REVIS ED APRIL 2015 ADS868x 16-Bit, 500-kSPS, 4- and 8-Channel, Single-Supply, SAR A DCs with Bipolar Input Ranges Addition al Channels in ADS8688 Multiplexer Gain (%FS) 1 Features •1 16-Bit ADCs wit h Integrated Analog Front-End • 4-, 8 -Channel MUX with Auto and Manual Scan • Channel-Independent Programmable In put Ranges: – Bipolar: ±10.24 V, ±5 .12 V, ±2.56 V – Unipolar: 10.24 V, 5.12 V • 5-V Analog Supply: 1.65-V to 5-V I/O Supply • Constant Resistive Input Impedance: 1 MΩ • Input Overvo ltage Protection: Up to ±20 V • On-C hip, 4.096-V Reference with Low Drift � �� Excellent Performance: – 500-kSPS Aggregate Throughput – DNL: ±0.5 LSB ; INL: ±0.75 LSB – Low Drift for Gai n Error and Offset – SNR: 92 dB; THD: –102 dB – Low Power: 65 mW • AUX Input → Direct Connection to ADC Inputs • SPI™-Compatible Interface with Daisy-Chain • Industrial Temperatu.
Keywords ADS8684, datasheet, pdf, etcTI, SAR, ADC, DS8684, S8684, 8684, ADS868, ADS86, ADS8, Equivalent, stock, pinout, distributor, price, schematic, inventory, databook, Electronic, Components, Parameters, parts, cross reference, chip, Semiconductor, circuit, Electric, manual, substitute
ADS8684 Recommendation Datasheet
ADS8684 SAR ADC, etcTI
ADS8684A SAR ADC, etcTI
ADS8681 SAR ADC Data Acquisition System, etcTI


WR Royale Tokens are already removed from Battle Rewards as of WAR ROBOTS Update 4.6.
Developers are planning to remove WR Royale in one of the future versions.
WR Royale was created as a way to farm Components before the new Workshop arrived. Now with the Workshop in place, WR Royale on its own became more or less redundant. We kept tuning it over the last months but eventually decided that War Robots doesn't need it anymore. Our plan right now is to gradually phase WR Royale away before combining it together with Black Market in a new, more cohesive and fun mechanic. Stay tuned.


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Cameron Allison signs with Blue Raiders
MTSU baseball signed a pitcher Wednesday.
Cameron Allison signs with Blue Raiders MTSU baseball signed a pitcher Wednesday. Check out this story on dnj.com: https://on.dnj.com/1j8vBwR
MTSU Dispatch Published 6:50 p.m. CT Nov. 18, 2015 | Updated 6:51 p.m. CT Nov. 18, 2015
Cameron Allison signed with MTSU on Wednesday.(Photo: Submitted)
MURFREESBORO — Pitcher Cameron Allison has signed a national letter of intent to join the Middle Tennessee State baseball program, head coach Jim McGuire announced Wednesday.
The talented southpaw will come to Middle Tennessee State from Pope High School in Marietta, Ga., where he also competed with the Team Elite travel team. Allison is rated as the 46th best player out of the state of Georgia and the 413th best player in the nation by Perfect Game.
As a junior, Allison went 6-2 on the mound with a 2.33 ERA while holding opposing batters to a .186 average and racked up 68 strikeouts in 57 innings of work.
Allison is a two-time Perfect Game All-American and was named to the All-Region 5-6A First Team and All-Cobb County Second team in 2015 while helping Pope High School reach the Georgia 6A State Semifinals.
"Cameron is a great sign on the last day of the early-signing period," McGuire stated. "He's a big left-handed pitcher with unbelievable upside who we think has pro potential and has an opportunity to come in and pitch for us right away.
"Coach Hall did a great job identifying Cameron after he decommitted from Auburn and giving us the opportunity to add him to this signing class."
Prior to signing with the Blue Raiders, the 6-foot-4 lefty was previously committed to play for Auburn before reopening his recruitment just before the early-signing period opened Nov. 11.
Allison joins an early-signing class that already includes catcher Aaron Antonini of Hollywood, Fla.; infielder Elliott Curtis of Waterloo, Ontario, Canada; and pitcher Grant Williams of Hendersonville, Tenn.

redpajama_set_name: RedPajamaCommonCrawl


In our experience, the most successful projects stem from a true partnership, rather than a client-vendor relationship.
The goal should be to find seasoned professionals who can counsel and guide you through your project and become a trusted partner. As our name suggests, we take this concept very much to heart and aim to essentially become an extension of a client's team for the duration of the project and beyond.
We understand that sometimes the RFP process is a requirement of your organization or company. If your executive board—or the law, in the case of government work—is mandating you utilize this process, we feel ya and we'll work with you.
We also understand that our potential clients want to make informed decisions and the RFP process seems like a good way to systematize that. However, we find them not to be an effective evaluation of us (or any agency).
RFPs work great for commodity-based work where evaluating the cost of identical solutions is the goal but they don't work well when looking to hire for a service that is more creative in nature. Design style, approach, and process can't be completely conveyed and compared in an RFP. An RFP will show how good a vendor is at writing RFP responses, but won't necessarily yield the best partner. Looking for a creative solution and using a process that removes creativity seems counterintuitive.
RFPs are rigid, leaving little-to-no opportunity to showcase our studio in a creative and impactful way. What's more, RFPs rarely provide an apples to apples comparison because there are too many differences between agencies and their approaches. Design can't be commoditized.
If we're going to invest the amount of time it takes to explain who we are, how we work, learn about your company and your project, we expect a fair opportunity at getting hired. In our experience, the time investment involved in responding to RFPs tends not to be proportional to the chance of ultimately winning the business.
True professional relationships are built on a foundation of respect and responsibility from both parties. Professionals are hired to apply their expertise and experience for a client's benefit. An RFP takes that away and creates more of a one-sided situation where "the vendor" takes on most, if not all, of the responsibility. Design works differently; it should always be a collaboration between client and design studio.
Tell us about your problem so we can hear you talk about it and collaboratively come up with a solution together.
RFPs rarely include budget. If a client is unwilling to indicate budget (ranges are fine) it's a red flag for us. A website's cost can vary from a couple thousand to hundreds of thousands of dollars. Indicating budget allows us to create a plan tailor-made for that budget (as well as your business goals). If budget isn't disclosed, it becomes an extremely inefficient guessing game.
Rather than comparing costs, consider comparing value. Chances are, your budget is fixed anyway. Besides, in most cases a final price can't be determined until a formal discovery process has taken place.
We're not suggesting that every RFP is guilty of this because most are not. However, there are times when organizations use the process to provide documented cover for a contracting decision that is already made.
Ok, so if not RFPs, then what?
Document the problems you are trying to solve and the short-term and long-term business goals you are hoping to achieve with as much detail as possible. Do not prescribe solutions at this point. Establish a rough budget and preferred timing.
Research your potential vendors and get an idea of their design style, approach, process and who they are. Narrow your list of potential vendors to as few as possible.
Set up phone calls with your top 1-3 vendors and learn more about them and discuss your problem/project.
Select one partner to do a deeper, paid discovery with to help you establish solutions and additional goals for the project. If you like what results, the cost estimate and relationship then work with this partner. If not, repeat.
You're going to work closely with these people for the next few months to bring your project to life and hopefully the next few years to maintain and improve it. So, make sure they are people you like, trust and actually want to work with.
Adjacent has and will be a tremendous asset for our brand and future growth. Fantastic results and deliver what they promise. Those eight principles they list are truly what they bring to the table and yes, they are awesome to work with.
The RFP process may yield companies who are OK with being just vendors, which isn't always in the best interest of a client and their project.
We're always happy to invest the time to meet with potential clients and have meaningful dialogue about how we might be a good fit. Sometimes lowering the RFP and raising the phone (or coming to meet us!) is a step towards a more worthwhile vendor partner relationship.


Available for the first time since its construction in 1961, a very bright, spacious detached house with a delightful westerly 60' rear garden. The property benefits from three spacious bedrooms, two large reception rooms and kitchen and is located in a lovely quiet cul-de-sac position in a very popular part of Hutton. The centre of Shenfield is a short walk or drive away and St. Martin's school is also very close.
This property offers enormous scope to enlarge, subject to the usual planning consents.
Three bedrooms. Two reception rooms. Shower room. Kitchen. Large westerly rear garden. Double depth garage. Quiet location.
A step rises to a UPVC wood effect front door with obscure glazed leaded light panel which opens to the entrance hall. Double glazed window to the side elevation. Dado rail. Spotlight. Coved cornice to ceiling. Wooden multi paned obscure glazed door with glazed panels to the side opens to the entrance hall.
A door opens to cloaks cupboard fitted with hanging rail and shelving and light. A spacious area. Coved cornice to ceiling. Dado rail. Radiator. A single balustraded staircase rises to the first floor landing below which is useful storage. Door to cupboard with shelving.
Containing a tiled shower enclosure. Back to wall WC with concealed cistern. Vanity wash hand basin with cupboards below and drawers to side. Tiling to floor and to full ceiling height with feature border. Spotlights to ceiling. Access to loft storage obscure glazed window to front elevation. Curved heated towel rail.
A lovely bright and spacious room drawing maximum light from a large bay window to the front elevation. Radiator. Coved cornice to ceiling. A central feature is a brick coal effect gas fire with brick surround, wooden mantle and tiled hearth. Two radiators. This room is accessed from the hall through multi paned glazed double doors and a door leads from here into the kitchen.
The kitchen has been fitted with a range of units which comprise base cupboards, drawers and matching wall cabinets with concealed down lighting on three walls. A marble effect worktop incorporates a one and a quarter bowl single drainer stainless steel sink unit with mixer tap and tiled splash back fitted above. Appliances to remain include a Bosch stainless steel five ring gas cooker with stainless steel extractor hood fitted above. Bosch Diplomat oven with Bosch microwave cooker above. Tiling to floor. Part tiling to walls. Refrigerator and freezer. Obscure double glazed window to rear aspect. Spotlights to ceiling. UPVC obscure double glazed door leads to a sheltered workshop area which is accessed from both the front and rear gardens. Double doors open to eaves storage cupboard fitted with shelving and accommodating the gas fired boiler and hot water cylinder.
This is a lovely bright and spacious room drawing maximum light from a set of double glazed sliding patio doors which lead to the rear garden sun terrace and a large box window overlooking the established and well tended rear garden beyond. Coved cornice to ceiling. Four wall light points. A central focal point is an electric fire with brick surround, tiled hearth and wooden mantle. Doors open to a practical storage cupboard with shelving and light. Two radiators.
This area is illuminated by a UPVC double glazed window that is fitted to the side elevation. Dado rail. Access to loft storage space. Coved cornice to ceiling. Doors to all rooms.
This is a sunny bedroom fitted with a wide double glazed window to the front elevation drawing the morning light. Radiator below. Coved cornice to ceiling. Three wall light points. Running along an entire wall are a range of wardrobes which provide ample hanging and shelving space with dressing table adjacent and drawers to the opposite side. Two built in cupboards fitted with shelving.
This is a good size dual elevation room with UPVC double glazed windows fitted to the rear and side elevations. Coved cornice to ceiling. Two wall light points. Built in cupboards fitted with hanging rail and shelving. Radiator.
This is a delightful bedroom fitted with a pair of double glazed french doors which open to a Juliette balcony providing a central view of the attractive gardens below. Built-in cupboard with hanging and shelving space. Dado rail. Radiator. Two wall light points.
This is an attractive spacious rear garden with a depth of 73' and a width of 47'. It has a westerly elevation, so is in sunshine throughout virtually the entire day. Running across the property is a paved terrace of an ideal size for eating out on warm summer evenings and this is retained by a low level brick wall and to the centre steps descend to a large lawn area. The garden has been largely laid to lawn interspersed with well stocked flowerbeds planted with a varied and interesting assortment of mature shrubs, plants and trees many of which are spring flowering and provide a delightful garden setting. Access from the terrace to the garage. As previously mentioned, to the northern boundary there is a sheltered workshop area accessed from both the front and rear gardens.
The front garden consists largely of a block paviour driveway capable of providing off street parking for five or six vehicles. Access to garage. The property is partially screened from the road by a mature hedgerow. A magnolia tree provides an attractive feature. Access to double depth garage.
The garage has a depth of 31'7 x 7'6. Two obscure glazed windows to the side elevation. Power and light. The garage has been fitted with an electronically remote controlled up and over door. As previously mentioned, a UPVC double glazed door leads to the rear garden terrace.


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In the Mediterranean, the coastal population was estimated at 146 miUion in 1990 and the urban coastal population alone is projected to rise to 176 million by 2025, with an addition of 350 million of tourists per year. In coastal zones, forecasting shoreline location and changes in time is a basic tool for decisional making regarding land management and future planning. Historical maps, aerial photography, topographic maps and a beach survey were used as data sources to detect the shorelines of the Sele Plain coastline between the towns of Salerno and Agropoli (southern Italy) and define its change from 1870 to 2009. By using the potential of ArcGIS release 8.3 software and its extension digital shoreline analysis system, we followed two main stages. The first required identification of the shorelines, reducing to a minimum the errors associated to the suitability of source material, distortion of the photographs, residuals in georeferencing, and seasonal shoreline variation. The second was to define the shoreline variations along 170 transects spaced every 200 m. This systematic analysis showed that in the Sele River plain the highest rates of erosion, generally localized at river mouths (Picentino River, mean value = 0.4 m/y; Sele River, mean value = 1.3 m/y), have decreased in the last 20 years, revealing that the beach system is acquiring new coastal stability.
Historical Shoreline Change of the Sele Plain (Southern Italy): The 1870–2009 Time Window
Alberico*, Ines;Amato, Vincenzo;AUCELLI, Pietro Patrizio Ciro;D'Argenio, Bruno;Di Paola, Gianluigi;PAPPONE, Gerardo


90% of Myschoolpulse pupils passed class in 2015!
2015 was an exciting year for Myschoolpulse especially as we opened a school in the Makassed General Hospital, our sixth!
We are happy to introduce our new teachers at Makassed, Mrs Nawal Nader and Mrs Manal Abi Abdallah.
In March 2015, Art therapy was introduced in a second hospital, Saint George Hospital UMC with Art Therapist, Ms Myra Saad.
Art therapy helps children tame the anxieties and fears related to their illness and improve their well-being.
In November 2015, Myschoolpulse launched its 2nd edition of "Pulses of Happiness", an annual exhibition displaying art produced by children under treatment at the Notre Dame de Secours hospital, Byblos. The event was organised by our Art Therapist Ms Soraya Obeid, with the kind participation of the prominent theatre celebrity M. Georges Khabbaz. Watch the Future TV report here.
Christmas is a cherished period of the year for Myschoolpulse and all its pupils. Personalised gifts are distributed to children and their room mates in all six hospitals and nurses receive their gifts too! It is a good occasion to share, smile, rejoice and hope.
This year, the Pulse 5K & 1K Run/Walk at Faqra club has gathered nearly 1,800 participants and raised $140,000. This annual event is eagerly anticipated both by kids and by adults!
Fundraising for Myschoolpulse can be hard work (and fun), with Farid Habib taking part in two Ironman challenges (in Zurich and in Mallorca) and raising over $10,000!
More challenges by Farid to come in 2016!
Discover other Myschoolpulse fundraisers or become one yourself by clicking here.
We cannot possibly name them all, but we would like to give special thanks to a few stars among Myschoolpulse supporters for their organisation of fundraising events: Laudy Asseily (Swim-a-thon), l'Ecole Bilingue (Fundraising sports day in the UK), Maissa Abou Adal and Ghia Hawari (Recettes de Vie 2) and Alice Mogabgab (Art conferences at Alice Mogabgab Gallery) for their precious support.
Since inception in 2010, Myschoolpulse has schooled 375 children undergoing treatment for life-threatening illnesses.
This would not have been possible without the help and contribution of each and every one of you.


We are the Trail Guardians for over 1000 miles of trails in Pennsylvania, Maryland, West Virginia & Virginia, including 240 miles of AT. Our territory begins in Central Pennsylvania at Pine Grove Furnace, continues thru Maryland & West Virginia to Harpers Ferry and extends into the mid-point of Virginia, including the Shenandoah National Park. .
Due to the Trail's historic legacy of volunteerism, our programs are focused on supporting and encouraging volunteers. These volunteers help ensure you and future generations can enjoy the trails today, tomorrow and for centuries to come. PATC members provide over 50,000 volunteer hours annually.
Since 1927, we have existed through the generosity, talents, and support of our members, supporters, and our volunteers.….. the very soul of the Trail. We hope you choose to Get Involved or Support Us.


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Admiral Horthy's bust defaced in Budapest
In the wake of the movement to topple statues in the United States and in Western Europe, a woman poured red paint on the bust of the interwar Regent. A Conservative analyst warns against arbitrary gestures towards history. READ MORE
Debate on World War One Freemasonry
In the new Hungarian Historikerstreit, right-wing commentators condemn mainstream left-liberal historians for denying what they consider to be the influence of freemasonry in producing the Trianon Peace Treaty. They maintain that the real controversy should be about the supposedly secret operations of internationalist liberal networks in our age. READ MORE
Weeklies on the new national curriculum
The debate over the new national curriculum continues in the weeklies. Left-wing and liberal commentators pour scorn on the government and accuse it of brainwashing kids. Pro-government and conservative commentators, on the other hand, find the critics ideologically biased. READ MORE
12th district mayor praised for confronting family history
A rabbi welcomes Budapest 12th district mayor Zoltán Pokorni's courage in facing up to his family history and publicly discussing his grandfather's involvement in the murder of Jews in World War Two. READ MORE
77th anniversary of the Disaster on the Don
A pro-government author describes the soldiers of both Hungary and the Soviet Union who fell in the Second World War as ordinary citizens who had no choice but to fight far from their homelands. READ MORE
Hóman remembered for both his merits and his sins
A pro-government writer admits that monuments to historic heroes should only be erected after a thorough public debate on their merits and faults. READ MORE
Responsibility of WW2 Allies in Hungary's Nazi occupation
Thursday, March 21st, 2019
In the leading online left-wing liberal news site, a historian accuses a colleague of trying to whitewash Hungarian leaders of responsibility for the Holocaust, by suggesting that the occupation in March 1944 was provoked by the Allied powers in clear disregard for the fate of Hungarian Jews. READ MORE
Remembering Hungary's occupation by Nazi Germany
A historian remembering Hungary's 1944 occupation contends that the Allied powers ignored the fate of Hungarian Jews. Another young historian calls for a more nuanced and less politicized interpretation of the 1944 events. READ MORE
Dispute over history curriculum
A liberal and a left-wing columnist harshly criticize a conservative historian's suggestion that history education should be used to strengthen national feeling. A pro-government commentator, on the other hand, welcomes the proposal. READ MORE
Dispute over Hungary's Turkic heritage
A conservative commentator accuses the government of advancing Hungary's Turkic ancestry out of geopolitical considerations. Another conservative historian dismisses the accusation, and welcomes the inclusion of the nomadic heritage in the Hungarian national identity. READ MORE


Qualified coach (ILM level 5) specialising in performance, career and executive coaching on a personal basis, or through businesses with wider aspirations of people development and improving business performance goals.
25 years' development experience in corporates. Coaching (personal & professional) for executives, entrepreneurs & senior managers .Team coaching for leadership teams, Coach Supervision.
What is your definition of success? My passion is helping others to answer that, and then go out and do it! If you want to make sustainable positive change to your lifestyle, get in touch.
Jayne Newman - What's Holding You Back?
What would it take to become the person that you have always aspired to be? Contact me for a free consultation to find out how I can help you move past fear and doubt and make the changes you need to create the life that you deserve.
Marriage and Relationship Coaching. Step-by-step strategies and tools for now and the future. When life feels wrong it's hard to know what to do next. I can help.
The purpose of working with a personal coach is to maximise your potential. Is there some area of your life, be it personal or professional, that you're looking to change? I will help you to meet, and often exceed, your goals and realise your dreams.
As a career coach, I can help you make the transition from one career to the next, helping you fine tune your plans, help you stick to your goals and act as a sounding board for your ideas.
I help people navigate through professional transitions such as promotions, restructures, mergers or new roles. By working with me you'll develop clarity & awareness, along with the practical steps/strategies you need to move forward towards success.
My passion has always been working with people, building strong relationships and teams and helping individuals to grow. I have run team development programs, coached and mentored people over the last 20 years.


El Furniture Warehouse approached us with a design for this large-scale laser-engraved signage in mind, which we modified a little to make it more efficient to manufacture.
Laser engraving looks great on wood. The varying grain hardness adds extra texture to your signage project. The sign is made up of multi-layered solid wood. The cross-grain lamination process helps keep the natural wood product from bending and splitting when subjected to extreme weather conditions. These signs are now up in Whistler Village!


Peter Scholze has been awarded the Fields medal, at the 2018 International Congress of Mathematicians in Rio, for "transforming arithmetic algebraic geometry over p-adic fields through his introduction of perfectoid spaces, with application to galois representations and for the development of new cohomology theories."
Perfectoid spaces are testament to the vibrancy of mathematics, having only been introduced by Scholze in 2011 (when he was just 23). And despite being such new mathematics, the concept of a perfectoid space has allowed Scholze and others to already prove important open problems in algebraic geometry and other areas. His work brings together the areas of mathematics of topology (which studies the shape of mathematical objects – read more here), Galois theory (which uses symmetry in the study of solutions of equations – read here) and p-adic geometry (which we'll describe below).
Adding 1s together in the real or rational numbers never gives you an answer of 0. This difference is captured by the characteristic of the field – for our field of arithmetic modulo 7, the characteristic is 7. (For any field defined as the arithmetic modulo some prime number p, the characteristic of that field will be the number p.) But as it isn't possible to do this in the reals or rationals; they both have a characteristic of 0.
Scholze worked on problems that involved different fields, sometimes involving both a field characteristic p (where p is a prime number) and a related field with characteristic 0. In particular, Scholze wanted to solve problems in fields with p-adic arithmetic, which have characteristic 0. In these infinite fields the p represents a prime number that defines a new measure of closeness (eg, 2-adic, 3-adic, 5-adic arithmetic and so on). In this new measure of closeness, two numbers are close not if they are close in value, but if their difference is divisible by a power of the prime number p. The higher the power, the closer the two numbers are.
For example, in the arithmetic we are used to, the numbers 3 and 67 are not particularly close, but they are closer than 3 and 1027. But in 2-adic arithmetic pairs of numbers are close to each other as they differ by powers of 2: 3 and 2017 differ by 210, making them far closer than 3 and 67, which only differ by 26.
Sometimes it is easier to tackle problems for fields with prime characteristic than it is for fields with characteristic 0. And so Scholze created the concept of perfectoids as a way to "tilt" the fields with characteristic 0 to ones with characteristic p. The method this involves is complex and the perfectoid space created is an infinitely winding, fractal-like object that bridges p-adic arithmetic and geometry. Perfectoid spaces are ones in which p-adic arithmetic can be used to understand the geometry and topology of the spaces, connecting different areas of mathematics and allowing tools from on area to be used in another.
Perfectoid spaces have already had a great impact on mathematics in a very short time: a growing new area of research, solving open problems and opening up new avenues for research. The concept might even shed light on some deeper unifying aspects of mathematics.
It also demonstrates the role of mathematics as a language, and the importance of having the right language for what you are trying to do. "The key issue for me is finding the right definitions, finding the right notions that really capture the essence of some mathematical phenomenon," says Scholze. "I often have some vague vision of what I want to understand but I'm often missing the words to really say that. But then sometimes I read some other paper and there's this definition that really clicks, and suddenly I can say what I always wanted to say." Scholze is expanding the language of mathematics and allowing us to tell new, beautiful and perhaps surprising mathematical stories.


"A Resource Guide for Beginning Farmers" (LF 0006) compiles training resources on everything from soil and composting to small farm equipment and whole farm planning; including information on food safety and seed saving. It's available from Iowa State University Extension and Outreach and the Leopold Center for Sustainable Agriculture.
Available at the Extension Online Store.


Gary has sold a number of homes for us that we have constructed over the last several years. He has exceptional selling skills and unlike many agents is a good listener and can help find the right buyer for a home. We enthusiastically recommend Gary to sellers in the Metrowest area.


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Electronic Theses and Dissertations (ETDs)
The Second Sex of Tomorrow? Constructions of Masculinity in the Moral Panic About Boy's Education. A Content Analysis of Canadian News Media
Gerke_Markus_2015_Masters.pdf (678.0Kb)
Gerke, Markus
Based on qualitative content analysis of articles in ten major Canadian newspapers between 1990 and 2011, this thesis asks how masculinity is represented in discourses about gender and education. My analysis suggests that the public discourse about boys' education is out of touch with scholarly research, and instead relies on a number of problematic tropes: (1) Schools are imagined as being run for girls and by female educators devoted to an anti-male agenda; (2) education is seen as a zero-sum game, in which what benefits girls must be necessarily bad for boys; (3) boys are being constructed as one homogenous group that is inherently different from girls, while any diversity among boys, especially in terms of race and class, is erased. I argue that the panic about boys' education must be understood as a backlash against feminism, based on a misreading of economic transformations through a gender lens.
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Hundreds of North Carolinians from across the state came to Raleigh on Wednesday to urge lawmakers to end gerrymandering and enact fair redistricting.
Organized by the nonpartisan NC Coalition for Lobbying & Government Reform, the Citizens Lobby Day to End Gerrymandering provided an opportunity for the public to speak directly with their state representatives on why they support changing the way congressional and legislative voting maps are drawn in the state.
The citizens lobby day came just a day after a bipartisan group of state lawmakers unveiled House Bill 200, which would take the power of redistricting out of the hands of partisan lawmakers and give it to nonpartisan legislative staff.
Under North Carolina's longstanding system, whichever party controls the legislature also controls redistricting. For decades, the result has been voting maps that heavily favor one party or the other and reduce competition at the ballot box.
Since 1992, nearly half of all legislative races have had only one candidate on the ballot. And just 1 in 10 of last year's legislative races were competitive. The other 90 percent were decided by double-digit margins.
"North Carolinians are tired of gerrymandering depriving them of a choice and a voice in our elections, and they are saying 'enough is enough.' It's time for fair redistricting," said Jane Pinsky, director of the NC Coalition for Lobbying & Government Reform.
A majority of North Carolinians support independent redistricting, as shown by a January survey from Public Policy Polling that found 59 percent of voters in favor of making the map-drawing process nonpartisan, with just 15 percent opposed to reforming the current system.
Over 240 civic leaders across North Carolina have signed a petition calling on the legislature to pass independent redistricting reform. A dozen towns and cities across the state have passed resolutions in support of independent redistricting. And more than 100 North Carolina business leaders have launched a coalition calling for an end to gerrymandering.
As 'gerrymandering' turns 205, is there a real chance for reform in North Carolina?


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Home > Community Histories > Bromham > Bromham in 1086
Bromham Index of Pages
1 and 5 Molivers Lane Bromham
1 to 9 Thistley Lane Bromham
109 to 113 Village Road Bromham
110 Stagsden Road Bromham
38 and 40 Village Road Bromham
45 to 49 Village Road Bromham
46 Village Road Bromham
6 Village Road Bromham
A Cart Accident in Bromham in 1272
A Ramble in Bromham in 1879
Baptists in Bromham
Berry Farmhouse Bromham
Bromham Before 1086
Bromham Church Alterations and Repairs
Bromham Church Architecture
BromhamHall
Bromham in 1086
Bromham Maps
Bromham Pound
Bromham Pubs
Bromham Registration and Early References
Bromham School in 1904
Bromham Schools
Bromham Vicarages
BromhamBridge
BromhamHouseAndColony
BromhamMill
Early Education in Bromham
EducationInBromham
Greenwood Cottage - 14 The Green Bromham
Hill Cottage - 37 Village Road Bromham
Kerry House - 15 The Green Bromham
Kerry Thatch - 16 The Green Bromham
LicensedPremisesInGeneral
List of Bromham Vicars
Little Park House Bromham
Methodists in Bromham
Moliver House - 15 Oakley Road Bromham
Molivers Wood Bromham
NonconformityInBromham
Old Yews Cottage - 129 Village Road Bromham
Rainbow Special School Bromham
Roman Catholicism in Bromham
Rose Cottage - 11 Oakley Road Bromham
Sir Lewis Dyve
Sir Lewis Dyves Escape
Sources for Education in Bromham
The Crown Public House Bromham
The Dispute Between the Botelers and the Dyves
The Dyve Family of Bromham
The Manor of Bromham alias Brayes
The Manor of Bromham Bowels
The Manor of Bromham Wakes
The Murder of a Priests Son in Bromham in 1272
The Old Smithy - 8 Stagsden Road Bromham
The Parish of Bromham in General
The Prince of Wales Public House Bromham
The Second Manor of Bromham
The Swan Public House Bromham
The Trevor Family
The Vine Inn Bromham
William Henry Allen
Domesday Book was commissioned by William the Conqueror (1066-1087) at Christmas 1085. It was designed to show who held every piece of land in the newly conquered Kingdom of England. It was known colloquially as the Domesday Book because it was seen as being as final as the Last Judgement and as difficult to conceal things from. The book does not cover the whole country - Cumberland, Durham, Northumberland, and Westmorland were omitted and London and Winchester likewise, along with some other towns. A separate book, called Little Domesday covered the counties of Essex, Norfolk and Suffolk and, despite its name, it is actually bigger and more detailed than the Great Domesday Book containing the other counties.
Domesday Book records four separate landowners in Bromham. Count Eustace of Boulogne held a hide and a half of land and his tenant, as mesne lord of the manor, was Arnulf of Ardres; Ardres is a small town a few miles from Calais. The holding had been held by two men named Alfwold and Leofric before the Norman Conquest. The holding was then worth twenty shillings. After these native Englishmen were deprived of the land in favour of the French count the land was still worth the same, but by 1086 its value had been halved. The usual explanation for this decrease, common in Bedfordshire, is that the land suffered from the depredations of William the Conqueror's armies as they moved through the county to crush revolts. The first County Archivist, George Herbert Fowler even produced a map showing the direction of travel of these armies based on the decrease figures in the Domesday Book. This was the only one of the four manors in Bromham to lose in value so perhaps the village was not on the direct path of any army.
Hugh de Beauchamp was an important local magnate, created Baron of Bedford by William the Conqueror's successor William Rufus [1087-1100]. He held six hides in Bromham and his tenant, who also held land in Biddenham, was a man named Serlo de Rots. This large manor contained sixteen villagers, five smallholders and six slaves, a total of twenty seven families as each of these men would just have been head of household and would have had any number of dependents. Even a fairly conservative figure of three each gives a population for the manor of over a hundred, a good size for the time. The manor also contained a mill (perhaps on or near the site of today's Bromham Mill) worth twenty shillings and 125 eels. There was also woodland enough for forty pigs. The manor had been held by Alfsi before the Norman Conquest and had been worth the large sum of £4. When acquired it was worth more, unlike Eustace's holding, one hundred shillings. This had risen to £7 by 1086.
The third holding belonged to Countess Judith, a niece of William the Conqueror, the daughter of his half-sister Adelaide. She was married to Waltheof, Earl of Huntingdon, a powerful Anglo-Saxon nobleman from whom William wished support to legitimise his reign. Waltheof rebelled against his new master twice, in 1069 and 1074, being executed for the latter offence. Judith's holding in Bromham was two hides and her tenant a man named Hugh who also had five villagers and two smallholders. This holding also contained a mill worth forty shillings and a hundred eels, again it may, or may not, have been in the vicinity of today's mill, the book has the cryptic note concerning the mill "it does not lie in this land". The holding had belonged to Godwin, a supporter of King Harrold II (whose father had also been called Godwin) and had been worth ten shillings, the same value as when Judith acquired it. Again, her land seems to have escaped depredations, by 1086 it had doubled in value.
The final holding belonged to one of the king's officers, a man named Osgeat and was small, just a virgate and a "two parts of a virgate". Unusually this man had held the land before the Norman Conquest and was still in possession. The land had been worth five shillings then and had doubled in value by 1086.


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H.J.M. Groen
P1.06 - Poster Session 1 - Prognostic and Predictive Biomarkers (ID 161)
Type: Poster Session
Track: Biology
Coordinates: 10/28/2013, 09:30 - 16:30, Exhibit Hall, Ground Level
P1.06-054 - Targeting MCL1 amplification in NSCLC through anthracycline-mediated transcriptional suppression (ID 3213)
09:30 - 16:30 | Author(s): H.J.M. Groen
Targeting oncogene dependency for effective therapy has been one of the most successful strategies for managing metastatic non-small cell lung cancer (NSCLC). Although validating therapeutically tractable oncogenic driver mutations are a major focus, non-driver mutations may also confer dependencies that may also be exploitable. The prosurvival BCL2 protein, MCL1 prevents mitochondrial apoptosis by blocking interaction of proapoptotic BH3 only proteins with their multidomain proapototic counterparts, BAX and BAK. MCL1 is often mutated in cancers, and ranks as one of the most frequently amplified loci at 1q21.2. MCL1 amplified tumours exhibit addiction to this oncogene. Anthracyclines have been shown to transcriptionally suppress MCL1. Phase IIA studies in NSCLC have shown that epirubicin has useful single agent activity in unselected patients, with a significantly greater response rate than that achieved with standard chemotherapy. We therefore set out to evaluate MCL1 addiction in NSCLC, its correlation with anthracyline induced apoptosis and the prevalence of 1q21.2amplification to support a planned 1q21.2 stratified phase II trial in NSCLC, (EORTC-1303-LCG).
RNAi targeting MCL1was conducted in NCI-H460, NCI-H1299, NCI-H28 and NCI-H23 cell lines. Doxorubicin activity was measured by viability assay and apoptosis was assessed by western blot. gDNA from cell lines was obtained by Phenol-Chloroform extraction. The QIAamp DNA FFPE Tissue Kit was used to extract gDNA from FFPE tissues. MCL1 amplification was quantified by real-time PCR with a set of two primers and one probe (minor groove-binding (MGB) hydrolysis probe assay) for the gene of interest MCL1 and the two reference genes CCT3 and H6PD. Tonsil samples were used as a control diploid population.
MCL1 silencing efficiently induced apoptosis in a subset of NSCLC cells, however we identified two cell lines that were resistant to MCL1 knockdown (NCI-H1299 and NCI-H28). Doxorubicin efficiently induced apoptosis in MCL1 addicted cells but exhibited significantly less activity in cells that were not addicted. We developed a genomic DNA based quantitative real time PCR assay to evaluate copy number variation (CNV) at the 1q21.2 locus. A clear correlation r[2] >0.91 was observed for 1q21.2 CNV compared with reference Conan Copy Number Analysis Tool (Cancer genome project, Sanger). Increased 1q21.2 copy number was consistently associated with MCL1addiction; however addiction also occurred in cells lacking 1q21.2 CNV, suggesting that MCL1 amplification represents a subset of MCL1 dependence. The concentration of doxorubicin was titrated against MCL1 protein downregulation into therapeutically sub-micromolar concentration range and we observed that MCL1 downregulation occurred coincidently with cleavage of poly-ADP ribose polymerase. We then screened DNA isolated from 19 adenocarcinomas, and identified 1q21.2 CNVs in 36.8%, with high level amplification (CNV >5) in 1q21.2 in 10.5%.
Targeting MCL1 addiction in 1q21.2 amplified NSCLC induces apoptosis and this dependence can be exploited by anthracyclines at therapeutically relevant concentrations. Given its significant prevalence in NSCLC, our data suggests that 1q21.2 amplification could be a novel non-driver mutation predictive for anthracycline response.
P2.04 - Poster Session 2 - Tumor Immunology (ID 154)
P2.04-001 - Myeloid derived suppressor cells (MDSC) are increased in patients with advanced non-squamous lung cancer (aNSQ) compared to healthy controls and early stage non-squamous lung cancer (eNSQ) and are related to the WHO performance status. Subanalysis of the NVALT12 study (ID 1802)
Background: recent evidence shows a role for immunotherapy via checkpoint antibodies in a subgroup of patients with non-small cell lung cancer (NSCLC). We have recently published the complex interplay between tumors and the immune system[1]. The modulating effect of the tumor on the immune system, mainly immunosuppressive, is challenging. MDSC are described to play a major role in this tumor associated immune suppression by inhibiting cytotoxic Tcell function. The aim of the present study is to relate the number of MDSC to two well-known prognostic factors in NSCLC: stage of the disease and WHO performance status.
Methods: MDSC were determined in peripheral blood mononucleair cell fractions of 195 treatment-naive NSCLC patients (185 stage IV (aNSQ), 10 stage I-III(eNSQ), and 20 healthy controls (HC)). WHO performance status was determined by experienced investigators prior to the start of treatment. In this abstract the relation between clinical data and polynucleair MDSC are presented. Flowcytometric analysis was performed within 5 hours after the blood was drawn. MDSC were characterized as CD16low,CD11b+,CD14-,HLA-DR-,CD15+, and CD33+.
Results: A large variation in the number of MDSC was observed in patients with NSCLC, also in the same stage of the disease and WHO performance status. In a subgroup of patients with eNSQ high MDSC levels were found, but also in patients with aNSQ low levels of MDSC were found. For the group as a whole, however, an increased number of MDSC was found in patients with aNSQ compared to HC and eNSQ (p<.001, in both comparisons). Comparison of the limited number of patients with of eNSQ and HC no statistical difference was found but there is a tendency for an increase in the number of MDSC per stage of NSCLC. The number of MDSC increased with worse WHO performance status ( p=0.05 between 0 and 2). Whether the number of MDSC has prognostic or predictive value to response to chemotherapy in all patients is subject of current research. Follow up data in all patients with response to chemotherapy, progression free survival and overall survival are at present collected.
Conclusion: Peripheral blood MDSC levels are increased in patients with aNSQ compared to eNSQ and HC. MDSC are increased in patients with worse WHO performance status. The number of MDSC shows large variation between patients with similar stage of the disease, showing the complex interplay between tumor and immune system. 1 Aerts JG, Hegmans JP, Cancer Research 2013
P2.11 - Poster Session 2 - NSCLC Novel Therapies (ID 209)
Track: Medical Oncology
P2.11-004 - A Phase Ib, open label, dose escalation study of the safety and pharmacology of PI3-Kinase (PI3K) Inhibitor GDC 0941 in combination with either Paclitaxel (Pac) and Carboplatin (Carbo) with or without Bevacizumab (Bev), or Pemetrexed (Pem), Cisplatin (Cis), and Bev in patients with advanced Non–Small Cell Lung Cancer (NSCLC). (ID 885)
The PI3K pathway has been implicated as a mechanism for cell survival and resistance to chemotherapy. PI3K may be an important target in NSCLC based on genetic alterations such as PIK3CA amplification, PTEN loss and PI3K mutations. Preclinical NSCLC models show that concurrent dosing of GDC-0941 improved activity of taxanes, platinums, and anti-VEGF therapy. This Phase 1b study aims to establish the safety and tolerability of GDC-0941 in combination with four frontline standard of care regimens in patients with advanced NSCLC.
This study contains two Carbo/Pac containing arms: Arm A (GDC-0941 + Carbo + Pac), open to squamous (Sq) patients and Bev-ineligible non-squamous (NSq) patients; and Arm B (GDC-0941 + Carbo + Pac + Bev) for NSq patients. The study also aims to evaluate two Cis/Pem containing arms in NSq patients: Arm C (GDC-0941 + Cis + Pem + Bev); and Arm D (GDC-0941 + Cis + Pem). Study objectives are to evaluate safety and pharmacokinetics (PK), and to determine the maximum tolerated/administered dose (MTD or MAD) of GDC-0941 in combination with chemotherapy regimens in all arms. Patients received GDC-0941 with 4-6 cycles of chemotherapy every 3 weeks (Q3W): Pac (200 mg/m[2]), Carbo (AUC 6 mg/mL·min), Cis (75 mg/m2), Pem (500 mg/m2), and Bev(15 mg/kg) . In all arms, GDC was given PO qd on Days 1-14 of a 21-day cycle. GDC-0941 +/- Bev were given until progression or toxicity.
As of 1 February 2013, Arms A, B and C have completed enrollment, with 18, 24 and 13 patients, respectively; no patients have been enrolled in Arm D to date. The most common Grade 3/4 treatment-related adverse events (TAEs) reported in ≥10% of patients were as follows: Arm A: neutropenia (50%), anemia (17%), febrile neutropenia (17%), leukopenia (11%) and thrombocytopenia (11%); Arm B: neutropenia (38%), lymphopenia (13%); Arm C: fatigue (31%), dehydration (15%) and hypertension (15%). The MTD/MAD in Arms A, B and C is 340 mg GDC-0941 in combination with either Carbo + Pac +/- Bev or with Cis + Pem + Bev, respectively. PK characteristics in all Arms were similar to historical profiles for the respective chemotherapy agents, as well as to the single-agent GDC-0941 profile. Confirmed partial responses (PRs) for patients with at least one post-baseline scan are as follows: 6 of 10 (60%) Sq patients; 11 of 28 (39%) NSq (Arms A and B) and 9 of 12 (75%) NSq patients (Arm C).
The combinations of GDC-0941 with either Pac + Carbo (+/- Bev), or Cis + Pem + Bev have been well tolerated at doses consistent with target PK exposures based on preclinical activity. Promising responses rates have been observed with all combinations evaluated. Evaluation of GDC-0941 + Cis + Pem is ongoing. A randomized Phase 2 study of GDC-0941 + Pac + Carbo (+/- Bev) in NSq and Sq patients is ongoing.
P3.11-037 - A phase II study of sorafenib and metformin in patients with stage IV non-small cell lung cancer (NSCLC) with a KRAS mutation (ID 2701)
Previously we reported a phase II study of sorafenib, a multi tyrosine kinase inhibitor, in advanced NSCLC patients with a KRAS mutation [1]. While sorafenib was found active in this group of patients, progression free survival (PFS) and overall survival (OS) were disappointing. Concurrent inhibition of multiple pathways may improve treatment outcome. Metformin is a save and well known antidiabetic drug. It has been described that metformin has inhibitory effects against mTOR, downstream of PI3K. An in vitro study of our group has shown synergistic effects of sorafenib and metformin which provided the rationale for this study [2]. In a post hoc analysis of the previous study, metformin users appeared to be among the longest survivors.
Patients with advanced NSCLC with a KRAS mutation, pretreated with platinum containing chemotherapy were included. Other inclusion criteria were: ECOG performance score (PS) 0-1, adequate organ reserve, creatinine clearance >60 ml/min and provided written informed consent according to local IRB regulations. A tumor biopsy was mandatory to confirm the presence of a KRAS mutation, prior to start of treatment. Treatment consisted of sorafenib 400 mg BID and metformin 1000 mg BID until disease progression or unacceptable toxicity. Dose reductions and discontinuations were specified per protocol in the face of CTC toxicities grade 3 and 4. Primary endpoint: disease control rate (DCR) at 6 weeks according to RECIST version 1.1. Secondary endpoints: duration of response, progression free survival (PFS), overall survival and treatment related toxicities. A 2-stage design was implemented (Simon's optimal design; p0=50%, p1=70%, alpha=0.05, beta=0.20) for a total of 45 evaluable patients.
Fifty-five patients were included between 1[st] of July 2012 and 1[st] of June 2013. Median age was 60 (range 34-77) years, 28 female (51 %), ECOG PS 0/1/2 16/32/1, all patients had stage IV disease. Of 47 patients disease evaluation after 6 weeks was available (Fig. 1). Two patients had a partial response, 23 stable disease and 22 patients had progressive disease. DCR was 53%. Results of secondary endpoints will be available at time of the conference.
This preliminary analysis suggests that the addition of metformin did not improve DCR, compared to previous reported results of sorafenib monotherapy in pretreated stage IV NSCLC patients with a KRAS mutation. [1] Dingemans AM et al. Clin Cancer Res. 2013 Feb 1;19(3):743-51 [2] Groenendijk FH et al. EJC. 2012 Nov; 48 (suppl. 6): p 48 Figure 1
P3.13 - Poster Session 3 - SCLC (ID 202)
P3.13-006 - Docetaxel-Carboplatin (DC) as Second Line Treatment in Patients With Small Cell Lung Cancer (SCLC): A phase II study. (ID 1877)
Patients with relapsing SCLC have a poor prognosis and options for treatment are limited. Paclitaxel in combination with platinum has demonstrated activity in first and second-line treatment. We conducted a phase II study to investigate the anti-tumor activity and safety profile of Docetaxel/Carboplatin (DC) in patients with refractory or relapsing SCLC.
SCLC patients who were refractory to or relapsed after first-line treatment and who did not receive platinum based chemotherapy within the 3 months before inclusion, were treated with Docetaxel (75 mg/m[2], day 1 iv) followed by Carboplatin (area under the curve 6, day 1 iv.) once every 3 weeks for 4-6 cycles. Primary endpoint was response rate (RR) and secondary endpoints were time to progression (TTP), overall survival (OS) and safety profile. Tumor response was measured according to RECIST version 1.1. Toxicity was evaluated according to Common Toxicity Criteria of the National Cancer Institute.
50 patients (29 male and 21 female) were included with a median (range) age of 67 years (46-82). The majority of patients had an Eastern Cooperative Oncology Group performance status of 1; median time off first-line treatment was 12 weeks. Average number of treatment cycles was 4 (range 1-6). Evaluable for response and toxicity were 45 and 48 patients, respectively. A complete response was achieved in 1 patient, a partial response in 24 patients, stable disease in 16 patients, and progressive disease in 4 patients (RR 73.5%; 95% confidence interval, 59 to 88). Median time to progression was 133 days (range 89-177). Median overall survival was 198 days (range 77-322). One-year survival rate was 34%. Hematologic toxicity grade 3 and 4 was leukopenia 19% and 8%, thrombocytopenia 10% and 2%, and anemia 4% and 0%, respectively, in a total of 186 cycles. Nonhematologic toxicity was diarrhea grade 3-4 (15%), stomatitis grade 3 (4%) and hyponatriemia grade 3 and 4 in one patient each. Seven patients were hospitalized due to neutropenic fever; no toxic deaths occurred.
Second-line DC in refractory or relapsing SCLC patients yielded a high RR and toxicity was relatively mild in these poor-prognosis patients. NCT00686985
PL03 - Presidential Symposium Including Top Rated Abstracts (ID 85)
Type: Plenary Session
Moderators:M. Boyer, K. Fong
Coordinates: 10/29/2013, 08:15 - 09:45, Plenary Hall, Ground Level
PL03.01 - Lung cancer probability in subjects with CT-detected pulmonary nodules (ID 1578)
The main challenge in computed tomography (CT) screening for lung cancer is the high prevalence of pulmonary nodules and the relatively low incidence of lung cancer. Thresholds for nodule size and growth rate, which determine which nodules require additional diagnostic procedures, should be based on the lung cancer probability of the individual.
Diameter, volume and volume-doubling time (VDT) of 9,681 non-calcified nodules detected by CT screening in 7,155 subjects were used to quantify lung cancer probability. Complete coverage on all lung cancer diagnoses was obtained by linkages with the national cancer registry. The nodule management algorithm recommended by the ACCP was evaluated and an improved algorithm, based on lung cancer probability, was proposed.
Lung cancer probability was low in subjects with a nodule volume <100mm³ (≤0.7%) or maximum transverse diameter <5mm (≤0.6%) Moreover, probability in these subjects was not significantly different from that in subjects without nodules (0.4%). Lung cancer probability was 0.9-5.8% for nodules with a volume 100-300mm³ or a diameter 5-10mm; the VDT further stratified the probability: 0.0-0.9% for VDTs>600days, 4.0% for VDTs 400-600days and 6.7-25.0% for VDTs<400days. Lung cancer probability was high for participants with nodule volumes ≥300mm³ (8.9-26.1%) or diameters ≥10mm (11.1-26.2%), even with long VDTs. Finally, raising the thresholds for nodule size recommended by the ACCP for an indeterminate result from 4mm to 5mm and for a positive result from 8mm to 10mm, would yield fewer follow-up CT examinations (from 29.8% to 22.2%) and fewer additional diagnostic procedures (from 8.9% to 5.3%) while maintaining the sensitivity at 94.2%.
Small nodules (volume <100mm³ or diameter <5mm) are not predictive for lung cancer. Immediate diagnostic evaluation is necessary for subjects with large nodules (volume ≥300mm³ or diameter ≥10mm) and only for subjects with nodules of intermediate size is VDT assessment advocated.


4k00:184K. Blacksmith brings dripping hot metal from furnace and he beats a piece of hot metal with a hammer on an anvil. Shot on RED EPIC - W Helium Cinema Camera in Slow Motion.
4k00:23Young couple telling about engagement to their friends during the party at night.


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The answer to the letter of His Excellency Archbishop Stanislaw Gądecki
Poznań, 13 June 2014
The Most Reverend
Stanisław Gądecki
Archbishop of Poznań
President of the Polish Episcopal Conference
Your Excellency,
I have read with great attention Your Excellency's letter concerning the programme of this year's Malta Festival, especially one of the presented shows – "Golgota Picnic" directed by Rodrigo García.
I am particularly concerned about the fact that the festival is accused of betraying the values that determine the quality of social life, such as peace, freedom, respecting the rights of fellow men and tolerance. In this context, I wish to underscore that I respect the opinion of the Church as an institution that contributed substantially to Poland regaining democracy and freedom of speech, however – contrary to the views Your Excellency refers to in the letter – the main theme of the show "Golgota Picnic" is not the Christian religion or the Passion, neither is it offending religious feelings. Information about the blasphemous character of the show is disseminated by people who did not see the show or saw only its fragments which they inform about in public.
In the intention of the director and according to critics' interpretation, the show "Golgota Picnic" is a metaphor for the ordeal of modernity, it speaks about our loneliness, fear of death and the exhausted possibilities of attaching any meaning to the world. Thus, the main subject of the show is the condition of the European society immersed in consumerism and spiritual void. Your Excellency maintains that "in the show Christ appears as a degenerate, egoist, responsible for all evil in the world". However, according to García it is not Christ, but we – people from the West, bored and focused on our pleasures and comfort – that are responsible for this evil due to our passivity and lack of reflection on our own existence. The director condemns the decay of the modern world and defends values that are dear to the Church. That is why many people call him a moralist. He says about himself that he is an idealist: "I am an idealist and so disappointment is a permanent element of my life. I like to imagine that man can be wonderful and as a result, every time when it turns out that it is impossible I experience the same disappointment all over again. Disappointment is an important element of my theatre in which I attempt to show the path from disappointment to hope and from hope to disappointment."
The director's theatrical language may be considered provoking by some spectators, but it is my conviction that accusing the creator of blasphemy is a significant exaggeration. In fact, blasphemy refers to the realm of faith, while a theatrical show does not, just like a work of literature or film. One can disagree with the director on the merits, reject his aesthetics or message, but in all of these cases we deal with an original voice of the creator, with an artificial situation created by him which is a subjective, processed image of the world.
The physical character of "Golgota Picnic" which is so often referred to by the protesters and called pornographic is factually justified and is a consequence of the references to Christian iconography which does not hide human physicality, but in opposite – exhibits it. Would we call the works of Giotto, Grünewald's, da Messina, Rubens or Bellini obscene or pornographic? In the show actors reconstruct the scenes from the works of the greatest Christian painters and engage in a dialogue with the iconography which was part of Christianity throughout its whole history.
The show "Golgota Picnic" was shown in many countries, including Brazil, Belgium, Spain, the Netherlands and Germany, but it triggered protests of Christian circles only in France. The majority of the protesters (according to the French police ca. 2 thousand people) were Lefebvrists. Furthermore, despite the protests triggered by the show in France, a few months ago Rodrigo García became the director of the French Centre National Dramatique in Montpellier. Nomination to this prestigious position expressed recognition for his works. The show "Golgota Picnic" was appreciated by critics and a large part of the French audience. The show does not solicit violence and does not publically insult the believers of the Church. It is an instance of the artist's personal expression and a manifestation of his outlook on the world. His statement is addressed to spectators who are open to this message and accept the language the artist employs. The fact that it is not of interest to everyone and some spectators can perceive it as offensive or provocative does not mean that its presentation should be banned.
In the present circumstances I would also like to express my deep concern about the information that we receive concerning the protesters' pickets and actions aiming at blocking the presentation of the show. The declared actions raise fears that the show's adversaries may be overcome by emotions and commit acts of a violent character.
Despite repeated explanations on the part of Malta Festival Poznań, the circles that inspired the protests do not want to listen to factual arguments and deprive other citizens of the right to participate in an artistic event which they bought tickets to and, hence, which they regarded as worthy of their attention. In view of that – taking into consideration Your Excellency's authority and the values which underlie the strong moral foundation of the Catholic Church – I kindly request your help in toning down emotions concerning this matter in the circles related to the Church.
I wish to assure once again that Rodrigo García's show "Golgota Picnic" in no way violates Article 257 of the Polish Penal Code. On stage no one insults a "group of population" due to their religious affiliation. Contemporary art has kindled polarized opinions for centuries. The fact that particular persons many not accept the message and form of the piece of art does not mean that their subjective opinion is to prevent other groups of the society from getting to know it and to hinder a large event such as Malta Festival Poznań.
The declared course of the protests will, it is my conviction, lead to the violation of Article 73 of the Constitution of the Republic of Poland which ensures "the freedom of artistic creation and scientific research as well as dissemination of the fruits thereof, the freedom to teach and to enjoy the products of culture" and can be conducive to setting a dangerous precedent reminding of Poland's grim past. It is my conviction that the demands to cancel the show are an attempt to introduce preventive censorship which was used in our country for the last time 25 years ago.
I read with great attention last year's letter of Your Excellency raising accusations that the festival presents shows of a blasphemous character in which Your Excellency expressed hope that the organizers would spare no efforts in the future so that the popular image of the festival is not associated with obscene shows. After all, in 2013 Malta Festival Poznań did not present the show which the letter referred to, namely "Sul concetto del Volto del Figlio di Dio" (only this show of Romeo Castellucci was protested against before). In turn, the programme of Malta included the show "The Four Seasons Restaurant" which does not refer to the Christian religion in the slightest degree (it refers to Mark Rothko's paintings and Friedrich Hölderlin's works). It is worth accentuating that the show "Sul concetto del Volto del Figlio di Dio" appeared as an artistic profession of faith to many clergymen and the French episcopate backed up the director. Romeo Castellucci is a highly valued artist all around the world, last year he received the Golden Lion for lifetime achievement in Venice and next year a retrospective on his work will take place during the prestigious Festival D'Automne in Paris.
Preparing the programme of Malta festival we spare no efforts to show the highest quality art and to work with renowned artists who take a stance in the discussion on contemporary world and take responsibility for their actions. This is the foundation of our decisions and it determines the good reputation of the festival on the European map of similar cultural events.
Taking into consideration the fact that a few weeks before the show's presentation, the event arises great interest of the public opinion, I believe that this letter explains the controversy around one of three hundred positions in the programme of his year's Malta Festival Poznań.
Michał Merczyński, director of Malta Festival Poznań


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HqO Raises $60M in Series C Funding to Power the Tenant Experience for Modern Office Environments
New funding from the world's top commercial real estate investors follows record-breaking growth and demand
April 14, 2021 07:00 ET | Source: HqO HqO
BOSTON, April 14, 2021 (GLOBE NEWSWIRE) -- HqO, the only tenant experience operating system for commercial office buildings, today announced it raised $60M in Series C funding from leading venture capital and commercial real estate firms. Previous investors Accomplice, Insight Partners, JLL Spark, Navitas Capital, DivcoWest, Allegion Ventures, and The Pagliuca Family Office participated in the round, joining new investors PruVen Capital, Cushman & Wakefield, and Suffolk Capital. The company has raised $106.9M to date, and will use the funds to support its rapid growth. As HqO continues to scale, it will expand its existing footprints in Boston, New York City, London, and Paris, as well as open new offices in Toronto and the Midwest and West Coast regions of the United States.
HqO is the undisputed leader in tenant experience technology with more than 150M square feet under management. The company tripled its revenue in the past 12 months and doubled its headcount. The new financing will further accelerate HqO's growth initiatives and continue the company's commitment to its world-class product through research and development, as well as support future mergers and acquisitions.
"Customer demand for HqO's offering continues to be extraordinary. The company helped landlords, property teams, and tenants alike adjust to the changes of the pandemic around the world," said AJ Malhotra at Insight Partners. "HqO is empowering office owners to bring their assets into the future through tenant experience, technology partnerships, and advanced data and analytics capabilities. This is crucial to the success of CRE, and we are excited to continue our partnership with the HqO team as they lead the tenant experience space."
HqO services over 60 commercial real estate clients worldwide, including Columbia Property Trust, Vornado Realty Trust, Nuveen Real Estate, Jamestown L.P., Hudson Pacific Properties, Grosvenor, Landsec, J.P. Morgan Asset Management, and Endurance Land. By using the HqO platform, landlords and property teams are guaranteed an advantage in the ever-changing commercial real estate industry. HqO lets office owners generate value by arming them with technology that blends the physical and digital office experiences to better engage with the people who occupy their buildings. These technology activations also provide important insights that can be leveraged to create the most value for their assets.
HqO Co-Founder and CEO Chase Garbarino said, "We're really happy with the composition of our Series C round being led by existing investors, but also bringing together a network of strategic investors setting HqO up for unprecedented growth as the world returns to offices. This round of funding is more than just capital; it comes with strategic partnerships that will significantly expand HqO's reach and differentiate our offering."
"The CRE industry is in the process of shifting the value equation away from the physical nature of the buildings to the tenants and employees who occupy them. We believe that a world-class tenant experience platform will help to satisfy this shift. After extensive research, we have identified HqO as the tenant experience market leader," said Travis Skelly at PruVen Capital. "Their best-in-class technology has made HqO the preferred platform for landlords. We are very excited to partner with the HqO team to help them deliver an unparalleled product with superior technology and client service."
"We're proud investors in HqO since 2018 and excited to support them as they expand their industry-leading tenant experience platform and technology leadership," said Yishai Lerner, Co-CEO at JLL Technologies. "HqO is a must-have product for any landlord seeking to retain, attract and build stronger relationships with their tenants."
About HqO
The world's leading commercial real estate firms count on HqO to help them deliver a state-of-the-art tenant experience within their properties. Active in over 150 million square feet in 7 countries, HqO is known for its tenant experience platform comprised of an award-winning tenant app, analytics suite, and partner marketplace. Our solutions put experiences and a sense of community directly into the tenants' hands while helping property owners uncover insights and take intelligent action to differentiate their assets. For more information, visit www.hqo.co, and connect with us on LinkedIn, Twitter, and Instagram.
Primary Contact: Kristin Concannon
Email: kristin.concannon@hqo.co
hqo series c funding commercial real estate technology proptech
https://www.hqo.co/


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Better Watch Out (2016)
USA/Australia. 2016.
Director – Chris Peckover, Screenplay – Zack Kahn & Chris Peckover, Story – Zach Kahn, Producers – Sidonie Abbene, Brion Hambel, Paul Jensen & Brett Thornquest, Photography – Carl Robertson, Music – Brian Cachia, Visual Effects – Orb VFX (Supervisor – Steve Anderson), Special Effects Supervisor – Tim Riach, Production Design – Richard Hobbs. Production Company – Storm Vision Entertainment/Best Medicine Productions.
Levi Miller (Lucas Lerner), Olivia De Jonge (Ashley), Ed Oxenbould (Garrett), Aleks Mikic (Ricky), Dacre Montgomery (Jeremy), Virginia Madsen (Deandra Lerner), Patrick Warburton (Robert Lerner)
Ashley accepts a job babysitting twelve-year-old Lucas Lerner while his parents go to a Christmas party. Lucas has a crush on Ashley and tries to make moves on her, which she brushes off with amusement. They are then interrupted by threatening phone calls and figures outside the house. A brick is thrown through the window with a note threatening to kill them if they leave. Lucas's best friend Garrett tries to flee only to be killed. A masked figure then enters the house and Ashley and Lucas are forced to hide. However, as Ashley finds, everything is not as it seems.
Better Watch Out was the second directorial film for Chris Peckover. Peckover had first appeared with Undocumented (2010), a quite reasonable Found Footage film about a documentary crew following a group of Mexican illegal immigrants as they are captured and tortured by vigilantes. Though Better Watch Out appears as a regular American film, it was actually shot in Australia. The film played at several international film festivals.
I had done only minimal reading on Better Watch Out before sitting down to watch it. And that way – with no raised expectations or spoiled surprises – is the best way to watch it. If you don't want to read on and prefer to watch instead with surprises intact, I won't hold it against you other than to urge you to watch the film.
Better Watch Out starts out seeming like it is a standard stalked babysitter film. This is a familiar set-up that goes back to the heyday of the slasher film with works like Halloween (1978) and When a Stranger Calls (1979). Chris Peckover delivers a fine variant on the familiar, peopled with characters that are written and portrayed with a wry sense of humour. Particularly good during these scenes is fourteen year-old Levi Miller as Lucas. The scenes with him playing at being grown-up and coming onto Olivia De Jonge come with a great deal of amusement. Peckover more than effectively delivers scares once we get to the scenes with the intruder in the house and Olivia De Jonge and Levi Miller trying to hide.
Babysitter Ashley (Olivia De Jonge) with Lucas (Levi Miller)
However, what we think is going on – a standard babysitter stalker film – proves to not the case at all and Better Watch Out pulls a major Conceptual Reversal Twist on us and turns everything we expect is happening on its head (although it is a twist that is given away by the below-listed trailer). It is at this point that the film starts to get really good where it is revealed [PLOT SPOILERS] that there is no intruder, that twelve-year-old Levi Miller and his friend Ed Oxenbould set it up so that Levi can have his way with Olivia De Jonge. This ends with her tied up and the two, principally Levi, tormenting her.
In these sections, Levi Miller totally owns the show, giving the performance of a lifetime as he quietly connives the situation, frequently being tripped up and outwitted in his machinations, and demonstrating increasingly psychopathic ruthlessness. There is a whole genre of Films About Evil Children and this contains one of the best performances one has seen. Chris Peckover does an excellent job of ratcheting tension with Olivia De Jonge tied up, various things going wrong or people intruding (often brought there with ill purpose by Levi Miller) and some nasty despatches. The results are enormously enjoyable.
(Nominee for Best Supporting Actor (Lev Miller) at this site's Best of 2016 Awards).
Director: Chris Peckover
Actors: Olivia De Jonge, Levi Miller, Ed Oxenbould, Aleks Mikic, Dacre Montgomery, Virginia Madsen, Patrick Warburton
Themes: Evil Children, Imprisonment Thrillers, Conceptual Reversal Twists, Christmas Films, Home Invasion Thrillers, Films of 2016
Goodnight Mommy (2014)
The Bad Man (2018)
Pet (2016)
Cadence (2016)
Don't Breathe (2016)
The Other (1972)
Krampus: The Reckoning (2015)
Phobias (2021)
Wolves at the Door (2016)
Son (2021)
Villains (2019)
Unholy Night (2019)
The Owners (2020)
Antebellum (2020)
Strange Circus (2005)
Eli (2019)
Rillington Place (2016)


Nudging Asteroids to Save the Earth (and how you can help).
All you have to do is look at the craters on the Moon. How do you think they got there?
On February 15, 2013, as a delegation from the Association of Space Explorers was discussing how to prevent future Earth-Asteroid impacts at the United Nations in New York City, a meteor entered Earth's atmosphere and exploded over Chelyabinsk, Russia. Luckily, no one was killed, but the explosion caused a brilliant flash brighter than the Sun and an enormous shock wave. As a result, approximately 1100 people had to seek medical treatment and more than 7,000 buildings were damaged.
On June 30, 1908 an enormous explosion known as the Tunguska Event rocked a remote region of Russia. The energy from that explosion is estimated to have been 1,000 times greater than the atomic bomb dropped on Hiroshima. It is estimated that the bomb dropped on Hiroshima instantly killed between 60,000 and 80,000 people. Although there have been other hypotheses put forth, the generally accepted explanation for the Tunguska Event is that a small asteroid or comet exploded when it collided with the Earth's atmosphere. Earth-asteroid collisions are not mere science fiction events created in the imaginations of Hollywood writers, they are real events and not so rare that we can afford to ignore them. Actually, we have the technology to prevent them.
Imagine the loss of life if an asteroid collided with the Earth and produced an explosion over New York 1000 times greater than the explosion over Hiroshima in 1945. New York and its 8 million people would be obliterated, and the U.S. financial system would be in danger of collapsing. It would trigger a world-wide depression.
"This is taking responsibility for the survival of life on planet Earth." — Russell Schweickart, former NASA astronaut (Apollo 9 Mission) and co-founder and chairman emeritus of the B612 Foundation.
Watch the video: Defending Earth from Asteroids – A panel discussion held at the Museum of Natural History in New York City on October 25, 2013.
Link to: B612 Foundation and consider a donation.


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Sinister Seven: Municipal Waste with "LAST RAGER" EP review
Friday, October 11, 2019 | Album Review, Interviews
By KRISTOF G.
It's a good thing we can count on Municipal Waste to always deliver top-shelf thrash metal—old-school, in-your-face-melting stuff—even if they keep busy elsewhere. The lads—screamer Tony Foresta (Iron Reagan), guitarist Ryan Waste (Bat, Volture), bassist Philip "Landphil" Hall (Cannabis Corpse, Iron Reagan), drummer Dave Witte (Brain Tentacles and so many other bands) and guitarist Nick Poulos (Bat)—always take good care of their MW fans, with amazing shows in equally awesome tours and consistently great releases with super-fun, gory artwork. Are you up for some seriously good ol' flesh-ripping, toxic-wasting and head-cutting, while drinking, bruising and cruising in a junkyard at top speed? It's all there in their new THE LAST RAGER EP from Nuclear Blast Records, dude. You might even find a bit of Kurt Russell in it too. So put your gas mask and hazmat suit on; this is the 10-minute classic thrash attack you need right now!
Municipal Waste has been blasting away for almost two decades now, and they aren't slowing down anytime soon. Plus, they're not strangers to horror. Beyond their albums' gory cover art and in-song homages (like the 2003 TANGO AND THRASH EP, dedicated to all things Russell), they've done videos with Troma ("Headbanger Face Rip," 2007) and Fangoria ("Acid Sentence," 2010), before teaming up with effects artist Norman Cabrera last year for the video for "Slime and Punishment" (see below), their latest album's title song, which is a homage to the video-store heyday in an Italian gore and body-horror way…as if the best bits of DEMONS and VIDEODROME were taped over a VHS of THE VIDEO DEAD.
During Heavy Montreal 2019, RUE MORGUE sat down with three-fifths of the band: first Witte and then, together, Foresta and Waste. All three are huge genre buffs and great, funny dudes to be around; here is some of their favorite horror-related stuff.
Who is your favorite horror-loving metalhead?
DAVE WITTE: Let's see…maybe King Fowley, he is like this big horror-movie nerd. The singer from Deceased. Actually, no—Scott Ruth, the singer from Ripping Corpse, back in the day; that was the most important band to me, growing up. That guy, he goes to all the horror conventions, he's the biggest horror maniac I know. A lot of his stuff is from H.P. Lovecraft and Clive Barker, movies like FROM BEYOND and BASKET CASE. We would go see all that stuff in the movie theaters. We saw ARMY OF DARKNESS together when it came out.
What is your favorite monster movie?
RYAN WASTE: BLACK ROSES, 'cause, like, the musicians turn into monsters and that's heavy metal. BLACK ROSES, hands down.
DW: Oh man, everybody loves GODZILLA. GODZILLA is amazing. But actually, PUMPKINHEAD and RAWHEAD REX. I've always been a big Clive Barker fan; I love all that stuff. I don't know if Pinhead is considered a monster… I guess Barker's NIGHTBREED had a lot of monsters in it back in the day. But you know what's really great? THE HOST, that Korean monster movie? That's a really good one.
TONY FORESTA: Oh, cool! I like THE HOST [without knowing Witte mentioned it] a lot.
What are your favorite slashers?
DW: Oh man, I remember this movie called TERROR TRAIN. It always kinda shocked me. And would you call THE TEXAS CHAINSAW MASSACRE a slasher movie? And MOTEL HELL? No, it's not really [laughs], but it's a good one, a comedy, yeah.
TF: Would MANIAC work? I liked that one.
RW: I like FRIDAY THE 13TH: THE FINAL CHAPTER, with Crispin Glover. I love THE BURNING too; it's got George Costanza in it, Jason Alexander.
What is your favorite Kurt Russell-John Carpenter movie?
RW: THE THING.
TF: One of my favorites!
RM: Dave just told me THE THING might be his favorite horror movie ever.
RW: And it's the best remake of all time. It's actually a remake. It's all about the practical effects—the dog, man, it's incredible. And ESCAPE FROM NEW YORK is a close second.
TF: I fuckin' love that shit!
What are your favorite zombie movies?
DW: I say, let's go with THE EVIL DEAD, or, like, ARMY OF DARKNESS. I mean, they are kind of like zombies, in a way, right, or they are more possessed people? Also, JASON AND THE ARGONAUTS had some skeletons, I liked that a lot. TRAIN TO BUSAN is cool. I know I'm jumping all over the place, but DAWN OF THE DEAD, NIGHT OF THE LIVING DEAD, the classics, of course.
What is your favorite horror film poster?
TF: The RETURN OF THE LIVING DEAD poster. That was in my first apartment; they had the soundtrack on the poster, with band names and shit. I always thought it was pretty cool.
RW: Can I add an honorable mention for video posters? I acquired a VIDEO DEAD one—you know, with the zombie coming out of the TV. The artwork is better than the movie! It's like the sickest artwork.
DW: I dunno, maybe ALIEN. Probably DEAD ALIVE. See, it might be a good zombie one for me too. 'Cause I like the real fucked-up shit, when it's so over the top, like WOLFCOP.
RW: The original BLOOD DINER poster was hanging above my bed. BLOOD DINER was one of the movies I was attracted to as a child in the video store; it just always stuck with me. It was a comedic kind of horror movie like BLOODSUCKING FREAKS or something, with the diner feeding body parts to the customers. [Our 2003 song] "Blood Hunger" was based on BLOOD DINER. I got our old drummer into it, Brandon [Ferrell], who passed away [in 2016]. He had given [the poster] to me when he moved out.
What is your favorite horrific album cover art?
DW: Carcass' SYMPHONIES OF SICKNESS. That was fucked up. I guess they were vegetarian at the time; that was the message, from what I remember. I know Wes Benscoter did some really cool gory stuff [Slayer, Cattle Decapitation, Mortician, Autopsy]. Thinking of it, Vince Locke might be the king of the disgusting album covers. The Cannibal Corpse stuff? It got banned in so many countries, cause it's so extreme. TOMB OF THE MUTILATED, BUTCHERED AT BIRTH…
TF: I've always liked the second Autopsy SEVERAL SURVIVAL cover, with the surgery room. That's one of my favorites.
RW: The soundtrack for TRICK OR TREAT [1986] with Sammi Curr on the front, by Fastway. And I love the album; that's my favorite Fastway record.
Stay tuned; there's more from Ryan Waste on movies and another exciting new projects to come…
Dave Witte
Ryan Waste
THE LAST RAGER
Tony Foresta


Truly Southern Low Country dish.
Peel shrimp and set aside.
In a 4-6 quart pot (cauldron) add oil, garlic, and sausage. Stir and cook over medium heat until garlic is golden.
Add thyme and onion soup mix. Gradually add water and whisk to blend, bringing to a boil. Add vermouth and simmer for 10 minutes.
Stir in Margaret Holmes Seasoned Collard Greens and Triple Succotash. Simmer for 10 minutes until sausage is cooked.
Raise heat and add shrimp to "cauldron". Cook until shrimp is pink approximately, 5-10 minutes. Serve with biscuits or warm bread, if desired.


Some people are skeptical about using toilets because they associate it with germs and dirt. However, toilets do not have to be messy or dirty or even stinky. And one of the best ways to improve your toilet experience is to have a bidet as it cleans the essential body parts without leaving much traces on the toilet bowl.
Fortunately, there are many reliable bidets on the market today. If you are shopping for one, then you may want to consider the Chrider Bidet for Toilet. This article examines the features, advantages, and disadvantages of this product.
The Chrider Bidet for Toilet promises convenience, reliable cleaning, and easy installation. This product is elegantly designed for comfort and proper sanitation.
The product manufacturer promises ease of use as those using the toilets only need to twist the knob to turn on the bidet and control the water pressure.
It has a self-cleaning nozzle that extends to release the aerated water for reliable cleaning of sensitive body parts. The nozzle also retracts by itself when not being used.
Buyers should not worry about installing this product; even non-plumbers can do this task quickly as the product manufacturer has already included the necessary parts needed for installation.
One only requires a screwdriver and allow 10 to 20 minutes of their time to do the installation. The manufacturer also provides a detailed instruction guide with accompanying pictures.
This mechanical bidet measures 16.9 by 6.4 by 3.4 inches and weighs 1.56 pounds. The product maker also promises an 18-month warranty and free extended warranty when buyers register their purchases online. Buyers who have concerns or issues with the product can also contact the customer support for help.
The Chrider Bidet for Toilet boasts of many features and is suitable for those who would like to control the water pressure of their bidet. It has a knob for water control and self-cleaning nozzle. When not in use, the nozzle retracts automatically for sanitation purposes.
There is no need to worry about the installation as the product manufacturer promises an easy time in installing this bidet. The package comes with a detailed instruction guide complete with pictures.
The product manufacturer also offers an 18-month warranty as well as an extended warranty for free for buyers who register their purchase online.
However, this bidet is not without any flaws as there have been reported incidents of leaking with this product.
The Chrider Bidet for Toilet has many competitors as other product manufacturers offer similar bidets.
For example, the BLENDX Bidet for Toilet Bidet Attachment also has a self-cleaning nozzle, and dual spray for front and rear washing and is simple and quick to install.
The user can also control the pressure and flow of water using the control knob and an option to use either cold and hot water for washing. It is made of metal and ABS valves and comes with a water hose measuring three meters.
However, this item has its flaw, too as there have been complaints of leaking.
Similarly, the ABHQP Bidet Fresh Water Spray has a single nozzle that can be easily attached to a standard two-piece toilet.
It has a control dial that lets users adjust the water pressure according to his or her preference. It is made from durable and high-grade plastic material to prevent rusting of the bidet.
The product manufacturer promises buyers that they will have a quick and easy installation that can be finished within 10 to 20 minutes.
The Chrider Bidet for Toilet has many great qualities. For one, it is a self-cleaning attachment that makes the use of bidet sanitary.
Using the item is convenient, too since the water pressure can be adjusted with the use of a knob. It is a self-cleaning tool that extends when the knobs are turned and retracts by itself when no longer in use.
Installation is easy as well as the product maker provides a detailed instruction guide with accompanying pictures for users to have a clear idea of what they need to do to install the bidet properly.
The product also comes with an 18-month warranty and extended warranty for buyers who register their purchases online. There are also customer service representatives who can handle a buyer's inquiry or question when needed.
When compared to other items on the market, the Chrider Bidet for Toilet has either less or more features than other bidets.
For example, one of its competitors the ABHQP Bidet Fresh Water Spray has a self-cleaning nozzle and control knob for the water pressure. This product is much simpler than the Chrider Bidet for Toilet.
On the other hand, the BLENDX Bidet for Toilet Bidet Attachment has similar features as well as more advanced ones. It also boasts of a self-cleaning nozzle and a control knob for water pressure adjustment.
However, there are other qualities that BLENDX Bidet for Toilet Bidet Attachment possesses that make it more advanced. For one, it is a dual spray that has a front and rear washing as well as the option to use hot or cold water. It is also made from ABS and metal valves for durability purposes.
So, is the Chrider Bidet for Toilet a worthy buy? Yes, if one is looking for a bidet that allows users to control the water pressure and an attachment that has the self-cleaning mechanism.
However, if one wants a product that has the option for the hot and cold water and dual washing, then this product is not the one to buy.
Overall, this product can still be considered a good and worthy purchase as it offers specific features that other products do not. Plus, the product manufacturer also provides an 18-month warranty and even an extended one, an offer that other makers do not provide.