text:
#pragma checksum "C:\Users\Nekozawa\Documents\Visual Studio 2015\Projects\KunappWinApp\cs\Views\DrillInPage.xaml" "{406ea660-64cf-4c82-b6f0-42d48172a799}" "D0469A700E66652C52C4F75AC8DFA950"
//------------------------------------------------------------------------------
// <auto-generated>
//     This code was generated by a tool.
//
//     Changes to this file may cause incorrect behavior and will be lost if
//     the code is regenerated.
// </auto-generated>
//------------------------------------------------------------------------------

namespace NavigationMenuSample.Views
{
    partial class DrillInPage :
        global::Windows.UI.Xaml.Controls.Page,
        global::Windows.UI.Xaml.Markup.IComponentConnector,
        global::Windows.UI.Xaml.Markup.IComponentConnector2
    {
        /// <summary>
        /// Connect()
        /// </summary>
        [global::System.CodeDom.Compiler.GeneratedCodeAttribute("Microsoft.Windows.UI.Xaml.Build.Tasks"," 14.0.0.0")]
        [global::System.Diagnostics.DebuggerNonUserCodeAttribute()]
        public void Connect(int connectionId, object target)
        {
            switch(connectionId)
            {
            case 1:
                {
                    this.navigatorImage = (global::Windows.UI.Xaml.Controls.Image)(target);
                }
                break;
            case 2:
                {
                    this.progressBar = (global::Windows.UI.Xaml.Controls.ProgressBar)(target);
                }
                break;
            case 3:
                {
                    this._anyMessage = (global::Windows.UI.Xaml.Controls.TextBlock)(target);
                }
                break;
            case 4:
                {
                    this.FirstAuthBlock = (global::Windows.UI.Xaml.Controls.Grid)(target);
                }
                break;
            case 5:
                {
                    this.timelineListView = (global::Windows.UI.Xaml.Controls.ListView)(target);
                }
                break;
            case 6:
                {
                    global::Windows.UI.Xaml.Controls.Button element6 = (global::Windows.UI.Xaml.Controls.Button)(target);
                    #line 82 "..\..\..\Views\DrillInPage.xaml"
                    ((global::Windows.UI.Xaml.Controls.Button)element6).Click += this.OnAuthorize;
                    #line default
                }
                break;
            case 7:
                {
                    global::Windows.UI.Xaml.Controls.Button element7 = (global::Windows.UI.Xaml.Controls.Button)(target);
                    #line 83 "..\..\..\Views\DrillInPage.xaml"
                    ((global::Windows.UI.Xaml.Controls.Button)element7).Click += this.PinExeCute;
                    #line default
                }
                break;
            case 8:
                {
                    this._pincodeTextBox = (global::Windows.UI.Xaml.Controls.TextBox)(target);
                    #line 84 "..\..\..\Views\DrillInPage.xaml"
                    ((global::Windows.UI.Xaml.Controls.TextBox)this._pincodeTextBox).GotFocus += this._pincodeText_GotFocus;
                    #line 84 "..\..\..\Views\DrillInPage.xaml"
                    ((global::Windows.UI.Xaml.Controls.TextBox)this._pincodeTextBox).LostFocus += this._pincodeText_LostFocus;
                    #line default
                }
                break;
            case 9:
                {
                    this._captionOrderTextBox = (global::Windows.UI.Xaml.Controls.TextBlock)(target);
                }
                break;
            case 10:
                {
                    this._orderTextBox = (global::Windows.UI.Xaml.Controls.TextBox)(target);
                    #line 70 "..\..\..\Views\DrillInPage.xaml"
                    ((global::Windows.UI.Xaml.Controls.TextBox)this._orderTextBox).GotFocus += this._orderText_GotFocus;
                    #line 70 "..\..\..\Views\DrillInPage.xaml"
                    ((global::Windows.UI.Xaml.Controls.TextBox)this._orderTextBox).LostFocus += this._orderText_LostFocus;
                    #line default
                }
                break;
            case 11:
                {
                    this._captionStatusTextBox = (global::Windows.UI.Xaml.Controls.TextBlock)(target);
                }
                break;
            case 12:
                {
                    this._statusTextBox = (global::Windows.UI.Xaml.Controls.TextBox)(target);
                    #line 65 "..\..\..\Views\DrillInPage.xaml"
                    ((global::Windows.UI.Xaml.Controls.TextBox)this._statusTextBox).GotFocus += this._statusText_GotFocus;
                    #line 65 "..\..\..\Views\DrillInPage.xaml"
                    ((global::Windows.UI.Xaml.Controls.TextBox)this._statusTextBox).LostFocus += this._statusText_LostFocus;
                    #line default
                }
                break;
            case 13:
                {
                    global::Windows.UI.Xaml.Controls.Button element13 = (global::Windows.UI.Xaml.Controls.Button)(target);
                    #line 51 "..\..\..\Views\DrillInPage.xaml"
                    ((global::Windows.UI.Xaml.Controls.Button)element13).Click += this.OnTweet;
                    #line default
                }
                break;
            case 14:
                {
                    global::Windows.UI.Xaml.Controls.Button element14 = (global::Windows.UI.Xaml.Controls.Button)(target);
                    #line 52 "..\..\..\Views\DrillInPage.xaml"
                    ((global::Windows.UI.Xaml.Controls.Button)element14).Click += this.ShoppingTweet;
                    #line default
                }
                break;
            case 15:
                {
                    global::Windows.UI.Xaml.Controls.Button element15 = (global::Windows.UI.Xaml.Controls.Button)(target);
                    #line 54 "..\..\..\Views\DrillInPage.xaml"
                    ((global::Windows.UI.Xaml.Controls.Button)element15).Click += this.LoadTimeLine;
                    #line default
                }
                break;
            case 16:
                {
                    global::Windows.UI.Xaml.Controls.Button element16 = (global::Windows.UI.Xaml.Controls.Button)(target);
                    #line 55 "..\..\..\Views\DrillInPage.xaml"
                    ((global::Windows.UI.Xaml.Controls.Button)element16).Click += this.JetStreamAttack;
                    #line default
                }
                break;
            case 17:
                {
                    this.title = (global::Windows.UI.Xaml.Controls.TextBlock)(target);
                }
                break;
            default:
                break;
            }
            this._contentLoaded = true;
        }

        [global::System.CodeDom.Compiler.GeneratedCodeAttribute("Microsoft.Windows.UI.Xaml.Build.Tasks"," 14.0.0.0")]
        [global::System.Diagnostics.DebuggerNonUserCodeAttribute()]
        public global::Windows.UI.Xaml.Markup.IComponentConnector GetBindingConnector(int connectionId, object target)
        {
            global::Windows.UI.Xaml.Markup.IComponentConnector returnValue = null;
            return returnValue;
        }
    }
}

redpajama_set_name: RedPajamaGithub


text:
About Journal of Turbomachinery
filter your search All ContentAll JournalsJ. Turbomach.
Boundary layer turbulence (59)
Boundary layers (41)
Flat plates (13)
Film cooling (12)
Boundary layer turbulence
Direct Experimental Measurements of Heat Transfer Coefficient Augmentation Due to Approach Flow Effects
Joshua B. Anderson, David G. Bogard, Thomas E. Dyson, Zachary Webster
J. Turbomach. March 2019, 141(3): 031011.
Topics: Boundary layers, Density, Film cooling, Flow (Dynamics), Heat transfer coefficients, Heating, Turbulence, Coolants, Heat flux, Boundary layer turbulence
Effects of Density and Blowing Ratios on the Turbulent Structure and Effectiveness of Film Cooling
Zachary T. Stratton, Tom I-P. Shih
J. Turbomach. October 2018, 140(10): 101007.
Topics: Boundary layer turbulence, Boundary layers, Density, Film cooling, Flow (Dynamics), Turbulence, Vortices, Cooling, Shear (Mechanics), Vorticity
Velocity Distributions for Low Pressure Turbines
J. D. Coull, R. L. Thomas, H. P. Hodson
J. Turbomach. October 2010, 132(4): 041006.
Topics: Blades, Boundary layers, Bubbles, Design, Diffusion (Physics), Flow (Dynamics), Pressure, Reynolds number, Suction, Turbines
Heat Transfer Augmentation Downstream of Rows of Various Dimple Geometries on the Suction Side of a Gas Turbine Airfoil
Jason E. Dees, David G. Bogard, Ronald S. Bunker
J. Turbomach. July 2010, 132(3): 031010.
Topics: Boundary layer turbulence, Boundary layers, Film cooling, Flow (Dynamics), Gas turbines, Heat transfer, Heat transfer coefficients, Shapes, Suction, Turbulence
Extended Models for Transitional Rough Wall Boundary Layers With Heat Transfer—Part I: Model Formulations
M. Stripf, A. Schulz, H.-J. Bauer, S. Wittig
Topics: Boundary layers, Surface roughness, Turbulence, Heat transfer, Boundary layer turbulence
Boundary Layer Influence on the Unsteady Horseshoe Vortex Flow and Surface Heat Transfer
D. R. Sabatino, C. R. Smith
Topics: Boundary layer turbulence, Boundary layers, Cascades (Fluid dynamics), Cylinders, Heat transfer, Vickers hardness testing, Vortices, Airfoils, Flow (Dynamics), Turbines
Modeling of Rough-Wall Boundary Layer Transition and Heat Transfer on Turbine Airfoils
M. Stripf, A. Schulz, H.-J. Bauer
Topics: Heat transfer, Surface roughness, Turbines, Boundary layers, Turbulence, Boundary layer turbulence, Airfoils
The Dynamics of the Horseshoe Vortex and Associated Endwall Heat Transfer—Part I: Temporal Behavior
T. J. Praisner, C. R. Smith
Topics: Flow (Dynamics), Heat transfer, Vortices, Vorticity, Boundary layers, Turbulence, Vickers hardness testing, Fluids, Boundary layer turbulence
Heat Transfer in Turbulent Boundary Layers Subjected to Free-Stream Turbulence—Part I: Experimental Results
Michael J. Barrett, Mem. ASME, D. Keith Hollingsworth, Mem. ASME,
Topics: Boundary layer turbulence, Heat transfer, Turbulence, Boundary layers, Wire, Skin friction (Fluid dynamics), Uncertainty, Enthalpy
Heat Transfer In Turbulent Boundary Layers Subjected to Free-Stream Turbulence—Part II: Analysis and Correlation
Michael J. Barrett, Mem. ASME,, D. Keith Hollingsworth, Mem. ASME,
Topics: Boundary layer turbulence, Boundary layers, Heat transfer, Turbulence, Flow (Dynamics), Reynolds number, Electromagnetic scattering
Discussion: "Development of Advanced Compressor Airfoils for Heavy-Duty Gas Turbines—Part II: Experimental and Theoretical Analysis" [ASME J. Turbomach., 122 , No. 3, pp. 406–414 (2000)]
N. A. Cumpsty
J. Turbomach. July 2000, 122(3): 414.
Topics: Aerospace engines, Airfoils, Boundary layer turbulence, Compressors, Gas turbines, Testing, Theoretical analysis, Turbulence, Reynolds number
Closure to "Discussion of 'Development of Advanced Compressor Airfoils for Heavy-Duty Gas Turbines—Part II: Experimental and Theoretical Analysis' " [ASME J. Turbomach., 122 , No. 3, pp. 406–414 (2000)]
Topics: Airfoils, Compressors, Gas turbines, Boundary layer turbulence, Flow visualization, Rotors, Stators
Discussion: "The Influence of Technical Surface Roughness Caused by Precision Forging on the Flow Around a Highly Loaded Compressor Cascade" [ASME J. Turbomach., 122 , No. 3, pp. 416–424 (2000)]
Topics: Cascades (Fluid dynamics), Compressors, Flow (Dynamics), Forging, Surface roughness, Boundary layer turbulence, Flow control, Gas turbines
Effect of High Free-Stream Turbulence With Large Length Scale on Blade Heat/Mass Transfer
H. P. Wang, R. J. Goldstein, S. J. Olson
Topics: Blades, Heat, Mass transfer, Turbulence, Boundary layers, Reynolds number, Boundary layer turbulence, Cascades (Fluid dynamics), Suction, Turbine blades
Mechanisms of Turbulence Transport in a Turbine Blade Coolant Passage With a Rib Turbulator
P. K. Panigrahi, S. Acharya
Topics: Coolants, Turbine blades, Turbulence, Flow (Dynamics), Stress, Boundary layer turbulence, Dynamics (Mechanics), Shear (Mechanics), Shear stress, Accounting
Nonlinear Separated Inviscid-Viscous Analysis of Oscillating Cascade Aerodynamics Using an Inverse Integral Method
J. M. Wolff, S. Fleeter
Topics: Aerodynamics, Cascades (Fluid dynamics), Airfoils, Boundary-value problems, Unsteady flow, Composite materials, Flat plates, Flow (Dynamics), Flow separation, Fourier series
Intermittent Flow and Thermal Structures of Accelerating Transitional Boundary Layers: Part 1—Mean Quantities
T. Wang, F. J. Keller
J. Turbomach. January 1999, 121(1): 98–105.
Topics: Boundary layers, Flow (Dynamics), Turbulence, Wakes, Boundary layer turbulence, Flat plates, Pressure gradient, Shapes, Skin friction (Fluid dynamics)
Analysis of the Flow in Vaneless Diffusers With Large Width-to-Radius Ratios
H.-S. Dou, S. Mizuki
Topics: Flow (Dynamics), Vaneless diffusers, Diffusers, Separation (Technology), Boundary layer turbulence, Boundary layers, Impellers, Pressure, Shear (Mechanics), Wakes
Spectral Measurements in Transitional Boundary Layers on a Concave Wall Under High and Low Free-Stream Turbulence Conditions
Ralph J. Volino, Terrence W. Simon
Topics: Boundary layers, Flow (Dynamics), Fluctuations (Physics), Spectra (Spectroscopy), Transfer functions, Turbulence, Boundary layer turbulence, Shear stress, Eddies (Fluid dynamics)
The Effects of Adverse Pressure Gradients on Momentum and Thermal Structures in Transitional Boundary Layers: Part 2—Fluctuation Quantities
S. P. Mislevy, T. Wang
Topics: Boundary layers, Momentum, Pressure gradient, Turbulence, Shear (Mechanics), Shear stress, Boundary layer turbulence, Eddies (Fluid dynamics), Fluctuations (Physics), Flux (Metallurgy)
Print ISSN 0889-504X

redpajama_set_name: RedPajamaCommonCrawl


text:
Akureyjar är öar i republiken Island.   De ligger i regionen Västlandet, i den västra delen av landet,  km nordväst om huvudstaden Reykjavík. Arean är  kvadratkilometer.

Terrängen på Akureyjar är mycket platt. Öns högsta punkt är  meter över havet. Den sträcker sig 0,6 kilometer i nord-sydlig riktning, och 0,7 kilometer i öst-västlig riktning.  Trakten runt Akureyjar består i huvudsak av gräsmarker.

Inlandsklimat råder i trakten. Årsmedeltemperaturen i trakten är  °C. Den varmaste månaden är juli, då medeltemperaturen är  °C, och den kallaste är december, med  °C.

Kommentarer

Källor

Öar i Västlandet

redpajama_set_name: RedPajamaWikipedia


Rehovot-based Evogene is establishing an R&D facility in St. Louis, Missouri.
The central focus of the facility will be Evogene's existing insect control program and it will be headed by Dr. James Presnail, Ph.D.
The company has received economic incentives from the Missouri Department of Economic Development for its choice of location.
Evogene (NYSE,TASE:EVGN), a leading plant genomics company, has announced that it has signed a Letter of Intent to establish a research and development facility in the Bio-Research and Development Growth (BRDG) Park on the campus of the Donald Danforth Plant Science Center in St. Louis, Missouri. Establishment of the facility is a key component of the company's previously disclosed entry into the field of advanced solutions for insect control. The project is expected to cost approximately $10 million in order to expand its existing predictive discovery and validation tools into this field.
The facility and insect control R&D activities will be headed by Dr. James Presnail, PhD, who previously held senior management positions at DuPont Pioneer and brings to the company two decades of in-depth knowledge and experience in the planning, execution and management of insecticidal gene discovery and efficacy testing.
At approximately 6,000-square-foot, the facility will feature state-of-the-art laboratories and insect rearing rooms and is expected to be fully operational by the end of 2015. It will house Evogene's growing insect control activities, initially focusing on ongoing product programs for corn rootworm and soybean aphids. Both field-specific modifications of the company's existing gene testing and validation infrastructure and new tools will be incorporated into the R&D at the facility. In addition, the center will aid the company's field-based data generation activities in the United States. Evogene has received a strategic economic incentive package from the Missouri Department of Economic Development for basing its R&D facility in St. Louis.
Based in Rehovot, Evogene is a leading company for the improvement of crop productivity and economics for the food, feed and biofuel industries. The company has strategic collaborations with world-leading agricultural companies to develop improved seed traits related to yield and abiotic stress (such as tolerance to drought) and biotic stress (such as resistance to disease and nematodes) in key crops, and is also focused on the research and development of new products for crop protection (such as weed control). The company has a fully-owned subsidiary, Evofuel, that develops seeds for second generation feedstock for biodiesel. For more information, visit www.evogene.com and www.evo-fuel.com.


We realize you may have a few questions, like what type of portable toilet do I need or how much is this going to cost. Just give us a call and one of our specialists in Syosset, New York will be happy to answer any questions you may have.
If your looking to rent a portable toilet in Syosset, don't accept slow responding companies or late deliveries. For over 20 years we have delivered our portable toilets on-time, when and where our customers need them. Give us a call today to experience why we're the #1 affordable porta potty rental company nationwide.
Have questions, need a quote, or want to schedule a delivery – just give us a call at 877-826-7488 or come visit us at our Syosset location to view our available inventory.
Hints For Renting a Porta John by Syosset, New York!
Acquiring a portable toilet might not be something you think of on a everyday basis, yet if you find yourself in need of them you're going to need a heads up on what's involved in the process.You've probably used a portable toilet at least more than a few times during the course of your travels, yet when it comes to renting a porta potty for your gatherings or weddings, you'll have to make sure you know a few vital facts beforehand.
For any outdoor events, and even many indoor events, will require facilities for your guests. From the smallest events to the biggest wedding, porta potties are always going to be a requirement to make sure your special event goes smoothly. How upscale your event will be, how many people will be attending and the length of time the event will last are the main factors determining which types of porta potties you're going to need. Reading up on the business and the types of portable toilets they have in stock is good advice before simply renting any old stalls.
Choosing a reliable portable toilet provider is first step to having a smooth event. Having swift customer service should be a top concern for whichever business you choose to rent your portable toilet from. Ask your portable toilet vendors about how fast they can react in case there is a problem with any of their stalls during your get together, since no one wants to have their guests exit prematurely due to a problem. There are a wide range of portable restrooms from basic portable toilets to upscale luxury restroom trailers, and all different types of stalls for different uses.
The best choice for basic porta potty rentals involving smaller occasions are usually going to be the single-stall option that you usually see on construction sites. Forbigger or more classy events, you can opt for the entire bathroom trailer choice, which gives you a full restroom area for people to use. Every portable toilet stall you rent should have a sanitation option, toilet paper and paper towels at the very least. If you have a smaller event and just need the most basics of portable toilets, you can always opt for an external hand washing area. Alternatively, you could go for an upscale portable toilet selection that includes amenities such as air fresheners and an inside basin with running water.
You'll want to consider portable toilet placement at your occasion or wordplace, as it's a important factor that could affect the success of your gathering or really slow down jobsite performance. The most ideal layout for a porta potty is a location that's dry, even, and is centrally located for all event attendees or construction site workers to access. The great thing about renting portable toilets is that you have the option to customize the toilets to fit your individual needs. Even the best event can be spoiled by low quality bathroom facilities, which is why you need to consider the quality of your portable toilet rental.
Portable Toilet placement is always an important factor to consider in order to ensure people won't have to walk a long distance to relieve themselves. It's suggested to place the porta potties in a easy to acces location that is easy to find for all guests, yet isn't in the way or obstructive of foot traffic. Remember that the portable toilet stalls will need to be between twenty and forty of access area for a service truck to come in if you need to get rid of their contents before you are finished using them. You will also want to make sure they aren't placed too close to dining or refreshment related areas, as you don't want potential odors to effect your attndees.
When you rent a portable toilet, it's important to know all the amenities it comes with. An entry level portable toilet is equipped with a few sanitary amenities like tissue paper, seat cover, a holding tank, dispenser, and lock on its door along with indicators. You might even spring for a high end portable toilet that has a flushing option and more amenities like air fresheners or flowing water with a sink. The most high end of mobile toilets will include a typical soap dispenser, mirror, and also a washing station. These addons are great for large outdoor weddings or formal events because guests will want to see how they look, and having an indoor light is a recommended amenity.
Depending on the kind of portable toilet you select and how long you'll be renting them for, your costs could be anywhere from fifty dollars on the low end to one hundred dollars if you are in a more costly area. You absolutely won't want to overestimate and end up paying for too many stalls, therefore it's important to acquire the exact amount you want in order to save on fees. Select the portable toilet rental agency that is close to the occasion's location as it can end up saving you some more money. Costs of portable toilets can to go up during wedding season, in the Spring or Summer times, so that's something to keep in mind when making your choice. It is suggested to rent the portable toilets ahead of time during the off season to get better prices. Now that you have a basic knowledge of portable toilet options and what goes into their offerings, you'll be able to make the best choice in order to host a great event regardless of how many people you're anticipating.


text:
Q: Services stops when i close the activity My project one service and one activity
in my activity i am having 2 spinners and 1 button
i am starting the service from my activity.
in the service it checks the onItemSelected on both dropdown list and run the code.
it works fine till is activity is active. if it is killed the service stops.
service is checking again n again from dropdownlist which is not accessible after i kill activity.
how can save the selected item in services and use it .
in mainactivity
    dropdown = (Spinner) findViewById(R.id.spinner1);
    dropdown.setOnItemSelectedListener(new CustomOnItemSelectedListener());
    dropdown2 = (Spinner) findViewById(R.id.Spinner01);
    dropdown2.setOnItemSelectedListener(new CustomOnItemSelectedListener());

i have used below code in services..
    public void onStart(Intent intent, int startId) {

     String m1 = (String) MainActivity.dropdown.getSelectedItem();
      String m1 = (String) MainActivity.dropdown2.getSelectedItem();

    if (m1 = "xyz")
    {
   switch m2:
        //code
    }
    else {
        switch m2:
          //code
         }

A: you can save your value in SharedPrefs
PreferenceManager.getDefaultSharedPreferences(this).edit().putString("value","myvalue").apply();

and get it next time this way
String v = PreferenceManager.getDefaultSharedPreferences(this).getString("value","");

redpajama_set_name: RedPajamaStackExchange


3 AM, 30 mph wind, snow/rain, big pile of black dead dinosaur rock, surrounded by boku hectares of corn stubble, free ranging beef, and not a hill or tree in sight.
I've been to some desolate places, and no offense to the residents, but damn.
On an upbeat note, this is the breadbasket of the country, with some hard working real Americans. Without this area we are buying grain from Russia and fish farming carp.
Legalize Freedom! Think, it ain't illegal yet.
Nebraska. Watch your corn hole buddy.
Wave "hello" to my family in Minnesota. Look to the northwest, you should see 'em.
Hey no whining I'm employed making good money and helping an industry and natural resource under assault from the EPA and the Loser-in-Chief..
2 of my favs, Condy and Bolton, they both got more balls than the whole Nobama Whitehouse and all their czars combined. Is that UhDannelUh behind them?
That doosh was on the head cocksuckers show tonight. Chris Mathews got a shiver up his leg...I noticed he's not on against O'Reily any more, tired of getting buried in the ratings.


First introduced to the world outside of Spain's Canary Islands by the American Anthropologist Dr. Carl Semencic in an article for Dogworld Magazine and in his books on the subject of rare breeds of dogs, the Presa Canario or "Canary Dog" is a large sized dog with a thick and muscular body. The head is broad, massive, square, and powerful. Proper head and good expression are part of the breed standard, and are manifest in the best breed specimens. The ears are normally cropped, both to create a more formidable expression and to prevent damage while working with cattle. If cropped the ears stand erect. In countries where ear cropping is banned the ears are close fitting to the head, they hang down and should be pendant or "rose" shaped. The lips are thick and hang in an inverted V where they join; the flews may be slightly loose. The interior lips are dark.
Males average between 23 to 26 inches (58 to 66 cm) at the withers with a minimum weight of 100 pounds (45 kg). Females average between 22 to 25 inches (56 to 63 cm) at the withers with a minimum weight of 85 pounds (39 kg). Very high weights could lead to a number of health problems. Too much weight is also known to compromise the dog's athleticism and working ability.
The breed is also characterized by a sloping topline (with the rear being slightly higher than the shoulders). Another characteristic of the breed is the shape of the paws (cat foot) and the catlike movement of the animal. The body is mesomorphic, that is, slightly longer than the dog is tall, contributing to the feline movement. The Presa should be powerful, balanced, and imposing in appearance. It is heavily built, but able to move with great athleticism.Presas are of strong character and are dominant animals requiring early socialization and obedience training. In some situations, the Presa can be aggressive toward other dogs and suspicious of strangers. Once the dog has been properly socialized and trained this becomes the exception rather than the rule. Many Presas share their homes with children, other dogs, cats, horses and other farm animals.


Gorse Cottage is a delightful semi detached bungalow set just a stone's throw from one of Pembrokeshire's finest sandy and surfboarding beaches. Conveniently located within walking distance of Broad Haven's facilities of shops, surf hire, pub and restaurants - something for everyone.
Comfortably and stylishly furnished with modern overtones, the open plan living space is well appointed with partial sea views from the lounge window seat.
A prettily landscaped front area and a small enclosed, lawned rear garden with patio offers space to relax and enjoy a barbecue on long summer evenings.
A great base for a beach holiday.
One Level Accommodation - This denotes that a bedroom, bathroom or shower room, whb/wc, living area and kitchen are on one level - guests must check the property access statement on the website or request a copy via email to base their decision on, if this is important to your stay.
Ground Floor: Hall, open plan kitchen/lounge/diner, double room, twin room, bathroom/overhead shower/whb/wc.
Facilities: Electric hob and oven, microwave, fridge, washer/drier, drying cupboard, TV/DVD player/CD player, iPod/radio, patio furniture, barbecue.
Heating: Electric heaters and night storage heaters.
Electricity: £15 per week Nov - March, free April - Oct.
General: Electric hob and oven, microwave, fridge, washer/dryer, drying cupboard, TV/DVD player/CD player, iPod/radio, WiFi, patio furniture, barbecue.
Pets: 1 well behaved dog.
What a beautiful home!We have enjoyed our stay here - covering much of the countryside, which is beautiful, and at the end of each day appreciated our return to Gorse Cottage.The local beach is clean and safe or Newgale which is just as sandy and good for children.


Santa Rosa Urban Art Partnership - Inquiring Systems Inc.
Santa Rosa Urban Arts Partnership (SRUAP) aims to strengthen the vibrancy of our community through arts programming and events, and to provide an inspirational and civic gathering place for artistic expression and engagement.
As Santa Rosa evolves from a suburban town into an urban city, and as population growth attracts more development, it�s important that we maintain and continue to support the cultural vibrancy of our amazing community. At Santa Rosa Urban Arts Partnership (SRUAP), we believe the way to balance growth and retain neighborhood character is through engaging arts programming; programming that encourages collective efficacy, fosters civic participation, and facilitates intercultural understanding by providing a common vocabulary for community building in our increasingly diverse society.
Please consider making a donation to Santa Rosa Urban Arts Partnership online or by check.
Get news and updates from ISI and Santa Rosa Urban Arts Partnership on Facebook!


text:
Abiomed leads latest FDA breakthrough designations for heart disease devices
Published Aug. 19, 2021
Sarah Silbiger via Getty Images
Abiomed and a clutch of other developers of cardiovascular disease devices have received breakthrough designations from FDA, setting them up to benefit from regulatory perks as they try to bring their products to market.
FDA awarded the breakthrough privileges to Abiomed's Impella ECP expandable percutaneous heart pump. Abiomed is pitching the experimental device as the world's smallest heart pump and the first that is suitable for use with small bore access and closure techniques. By developing a pump that is smaller than its existing Impella products, Abiomed is aiming to enable more coronary artery disease patients to receive hemodynamic support.
Earlier this month, Abiomed CEO Mike Minogue told investors an early feasibility study of the device is running ahead of schedule. Abiomed has enrolled 25 patients and submitted data for review ahead of the planned expansion of the study. The progress led one analyst to speculate about whether the device could win approval around the end of 2023.
Hancock Jaffe Laboratories received FDA breakthrough status for its potential treatment for chronic venous insufficiency. The VenoValve device is a prosthetic valve that is designed to mitigate the failure of the venous valves that enable blood to return to the heart from the lower limbs. Hancock shared first-in-human data on the device last year and is now preparing to move into a pivotal clinical trial.
FDA awarded a breakthrough designation to Neuralert Technologies' medical device for hospital stroke detection. The University of Pennsylvania spinout is developing the Neuralert Monitor in the belief that the current manual approach to detection means only a fraction of in-hospital strokes are identified in a timely manner. Neuralert's product is designed to accelerate stroke detection through the use of wearable devices that detect the onset of asymmetric movement.
Helius Medical Technologies received breakthrough status for a device targeted at patients who are suffering dynamic gait and balance deficits because of symptoms from stroke. The Portable Neuromodulation Stimulator delivers electrical stimulation to treat gait deficit, and is already indicated for use in patients with mild-to-moderate symptoms from multiple sclerosis.
CytoSorbents is the other recent recipient of a breakthrough device designation for a cardiovascular disease product. The breakthrough status covers a technology for removing the direct oral anticoagulants apixaban and rivaroxaban in a cardiopulmonary bypass circuit. Removing the drugs could "reduce the likelihood of serious perioperative bleeding in urgent cardiothoracic surgery," according to CytoSorbents.
In other disease areas, Altoida received breakthrough designation for a non-invasive software device that predicts if a person with mild cognitive impairment will develop Alzheimer's disease in the next 12 months. The artificial intelligence prediction is based on the patient's performance on "a 10 minute set of augmented reality and motor activities on their smartphone or tablet."
Finally, FDA granted breakthrough device status to Swing Therapeutics' digital therapeutic for the management of fibromyalgia. The device delivers a form of cognitive behavioral therapy that could improve the function and symptoms of fibromyalgia patients.
Filed Under: Medical Devices, Policy & Regulation, Diagnostics, Digital Health
Will a software bill of materials help or hurt medical device cybersecurity?
President Joe Biden's executive order calls for SBOMs, and the FDA wants to require premarket submissions to have an inventory of third-party device components. AdvaMed is concerned the data could be exploited by hackers.
By Greg Slabodkin • Oct. 7, 2021
What does J&J's Ottava delay mean for Intuitive and Medtronic? It's complicated.
The setback doesn't remove hurdles the rivals face playing catch-up to market leader Intuitive's da Vinci, which has a two-decade head start.
By Ricky Zipp • Oct. 28, 2021


This is Smitty. People call him Smitty, but his real name is Richard. He doesn't like to be called a shoe-cobbler. In his 80-year-old workshop, he tells me that he rebuilds the shoes. He doesn't just patch them up and call it good.
Dusty machines, a glue container with years of dried-up glue on the sides, old-fashioned tickets to mark the shoes, his workshop is amazing. It also has very good lights.
I paid him a visit after finishing the video about him to show it to him. It really made my day when he told me how much he loves it.


Just as in the summer of 2006, when the northern part of the country huddled in bomb shelters during the Second Lebanon War and the rest of the country carried on with its business, a new war has come that affects Israelis — at least in part — according to geography.
Leah Hassan, a nursery school teacher in Ashkelon, left her home Tuesday for the first time since the Israeli operation on Gaza began.
In Tel Aviv, meanwhile, Shlomo Dora, 31, sits back on a black leather chair at a popular bistro with the sound of a crooning jazz singer on the stereo and catches up with a friend.
In tiny Israel, he insists, far is never that far away.
Nearby, behind the counter of a cafe known for its homemade cakes and jams, two workers disagree about how out of touch the locals are about the fear and rocket fire in cities like Ashdod only a 45-minute drive south.
"Some of really do feel close to what's going on," said Shani Asulin, 24, a waitress at the cafe.
Asulin is worried for her best friend, who works in army intelligence near the Gaza border, and her brother, a border policeman who has been doing security at demonstrations by Arab Israelis in the north.
Mazor, a Haifa native, said some do seem more affected and subdued by the fighting.
Asulin offers that the night before, she left a dance club at 2 a.m. and the place was still packed.
In Sderot, Yigal Sal, 39, who has been unemployed since a Kassam hit his clothing store two years ago, says he does not leave the house much these days. His apartment, like most Sderot homes, has no protected room, so instead the family crouches together under the dining room table.
Sal is very worried about his 8-year-old son, Mike, who has known life under rocket attack since he was born and still has trouble sleeping through the night alone.
Most nights, and especially since the fighting began, Mike creeps into his parents' bed. Alone in his own bed he regularly wets his sheets – a sign in children of post-traumatic stress disorder.
"Everyone stays inside and looks towards God to make sure a Kassam does not hit him or his loved ones," Sal said.
His daughter Noy, 17, fled to Eilat for the first few days of the war but has returned. Most of her friends have left the city; she spends most of the day online sending them messages.
"It was hard to come back to the Kassams," Noy said in a quiet voice.
When an alert goes off, she dutifully ducks under the dining room table.
"We wait to hear the boom and I feel my heart racing," she said.
Talia Levanon, the director of the Israel Trauma Coalition, says it's been a major challenge trying to maintain the resiliency and sense of stability among children in Sderot, which until the fighting began a week and a half ago was the main target of Hamas rocket fire.
"We find ourselves treating the same people over and over again, and we have to be creative and use all our resources," she said Sunday during a visit by New York City Mayor Michael Bloomberg to a Sderot clinic.
The Israel Trauma Coalition, which is supported by the UJA-Federation of New York, is providing individual and community therapy to Sderot residents. Tel Aviv and other cities and towns also are becoming places of refuge for southern residents.
Shraga Zaiger, a 45-year-old lawyer, has been hosting his mother since Israel's operation against Hamas in Gaza began Dec. 27. On Tuesday he had taken her out for lunch at a crowded cafe.
"We are all very worried, but it's the personality of Israelis to go on with life as usual even during war. It was the same way when I was a soldier in Lebanon," he said, referring to the First Lebanon War, which began in 1982.
His mother, Malka, has spent most of her life in Ashkelon and is surprised to find herself a refugee from it.
"It's strange but this is our life," she said.
For Galit Sabar, 30, a Tel Aviv University student, it's no longer possible to feel far from danger. She lives in Gadera, 20 miles from Gaza, which on Tuesday was hit with its first Grad missile. She woke up to the sound of a siren.
"It's getting closer, and there is talk they have rockets that could get to Rehovot," she said, waiting her turn at a Tel Aviv hair salon. "In Gadera especially now, people feel the situation more, but in Tel Aviv you really hardly feel it at all.
This story "In Israel, Geography Dictates Mood" was written by Dina Kraft.


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The Lincoln Cathedral Code and the Olympic Torch
On March 12th 2010, against all odds and ahead of that summer's world cup finals in Africa, the 36.5 centimeters tall, 5kg solid gold chalice shaped soccer World Cup was lowered into Sincil Bank, home of lowly Conference National league Lincoln city football club, by helicopter as a token acknowledgement of the club's 125th anniversary. Nowhere else was it making an appearance within the UK. This was an amazing synchronicity as the symbology of the 'Blade and the Chalice' to modern Grail hunters is even mentioned in Dan Brown's 'The Da Vinci Code'. The helicopter (blade) bringing the world cup (a golden chalice) – to Lincoln. After its arrival it next went to Paris where Brown's novel placed the final resting place of Mary Magdalene. The visiting team that played Lincoln that night was Hereford United, Hereford Cathedral home to the 158cm x 133cm golden 13c Mappa Mundi or 'Map of the World'. What connects both Cathedrals of Lincoln and Hereford was the once chancellor of the former, Walter Map (1140-1210) long considered to be the author of a lost prose entitled 'Quest of the Holy Grail' on which later accounts of the Arthurian legacy were based. In the centre of the Mappa Mundi is placed Jerusalem. Three miles to the west of Lincoln Cathedral is the small village of Jerusalem, a place name unique to the British Isles. One of Hereford United's nicknames is 'The Lillywhites', a synchronicity as the white lily is the emblem of Mary Magdalene. The origin of the name 'Sincil' is untraceable until we employ the cryptic code of the Knights Templar to reveal phonetic 'Sign Seal', completing the synchronised collection of blade and chalice of the Grail, a sign, and the seal, the word 'seal' meaning an authentication or attestation.
The Mappa Mundi with Jerusalem at the centre
The synchronicities involved in what I have announced as the 'Lincoln Cathedral Code,' are beyond meaningless coincidences, and all began happening after 1986 when I encountered a UFO in the close vicinity of Rennes-le-Chateau, France.
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The Collective Unconscious and its tool of synchronicity works through the unwitting agency of the human and can employ whom ever it chooses, often sensitive painters and sculptors, to leave 'clues' wherever and whenever it wills throughout the centuries. It was the author Henry Lincoln who primarily kick started the modern day search for a symbolic Magdalene related Grail back in 1982 as major author of three in the best seller 'The Holy Blood and the Holy Grail'. He went looking for evidence at Rennes-le-Chateau for clues. They were there, but only I discovered they led back to the place name bearing his surname, Lincoln in England! The Chateau, dedicated to Mary, is high up a hill and the church has a demon guardian statue inside. Lincoln Cathedral, high up a hill has its own demon guardian, the Lincoln Imp, a 'v' notch on its left leg, the acknowledged symbology of 'the chalice'. A church of Mary Magdalene was demolished and built upon to make way for the Cathedral in 1097. No sooner had I announced the code in 2005 when who should come knocking on Lincoln Cathedral's door to film scenes for Brown's 'The Da Vinci Code' movie, but Hollywood itself. True irony, a fictional movie about a Code, in a Cathedral that actually does have one, initially found in 2005 when instead of a cup or loaf on Christ's platter at the scene of the Last Supper at the Great East Window, we discover a dog, which goes on to appear a further twice elsewhere! The dog a symbol for the dog star Sirius, the blazing emblem of all Freemasonic Lodges. When the HBHG authors Baigent and Leigh sued Random House, publishers of Brown's novel for plagiarism, they were represented in the Courts by QC Raynor James, the same sounding Rayner being the name of the family tomb that the Code finally leads us to the lost treasure of the Templars at a burial grounds only yards adjacent the Cathedral.
Lincolnshire has more than its share of Templar activity and the Cathedral, viewed from the air, is in the shape of the Cross of Lorraine, the original Templars' emblem.
Lincoln Cathedral
The famous Rennes Parchments, discovered its parish priest Sauniere, decode at Lincoln Cathedral, the Shepherdess 'no temptation' being a pregnant , therefore no sexual temptation, depiction of Queen Eleanor high up the SE buttress, looking directly over at the secret marker tomb, in the St Margaret burial grounds, this saint herself a shepherdess. 'That Poussin and Teniers hold the key peace' (piece) is explained by the presence of the shepherdess in Poussin's 'Shepherds of Arcadia (1341) and Teniers painting 'The Cabinet of Archduke Leopold' which contains over 50 smaller paintings in the canvass, its central depiction that of St Margaret, a green canvas suspiciously draped over the top right of the frame. St Margaret's burial grounds is also known as 'The Green'. The French word 'tenure' means 'to hold,' in the sense of 'to aim, to direct' indicating our Eleanor statue that holds the gaze of the marker tomb.
Shepherdess No Temptation stares directly over at the Marker Tomb
St Margaret, centerpiece of ' The Cabinet of Archduke Leopold' (click to enlarge)
'681' in the Parchments are discovered when we look up at the Cathedral East Sun Dial, the equal spacing between the numbers 6, 8 and the 1 in the 10 explain the cipher. 'By this horse and cross of God' is found within the Cathedral hidden under a seat in the Choir stalls, a depiction of a falling knight shows a horse with its legs crossed. It has seven studs on the right of its fastenings and four on the left. The crossed legs serve as the sign for multiplication, and when we multiply the 7×4 we arrives at 28, the exact recorded plot number of the tomb in the burial grounds that is the marker.
681 Sundial completes the demon guardian
By This Horse and Cross of God – 7 x 4 = 28
A straight line drawn through the eyes and the centre of the cross of the kneeling Magdalene in her painting at the Rennes church ends at the 28th in a series of oblong tomb shapes read from left to right. In the background we can clearly see Lincoln Castle and its surroundings. The Angel Choir in the Cathedral has 28 carvings. 'I complete this guardian demon at noon blue apples' is explained when we return to the Sundial and its Latin motto 'Pereunt et imputantur'. We 'complete' the Demon imp by expanding the word' imp' to 'imputantar'. At noon on 22nd July, the feast day of Mary Magdalene, straight out a scene one would expect in an Indiana Jones movie, sunlight shines through a specific pane glass to create a dancing dappling effect on the stone floor that looks like red and blue apples! The second of the Parchments decodes on a plaque at the statue of Grail Poet Laureate Lord Tennyson (also with a dog!) – 'For Dagobert II King of Sion is this treasure and it is death'. Both the word 'Sion' and Roi', French for king, interlock on this statue, in the same 'v' notch as on the imp's leg, the reference to treasure and 'it is death' telling us that what we seek resides in the nearby burial ground, only yards away.
Extended line hits tomb shape number 28
Sion and Roi encrypted in 'V' notch
The last few lines of Tennyson's 1869 epic 'The Holy Grail' poem, contain cryptic references to within the Cathedral to confirm the Code. Further startling evidence and synchronicities that interlock involve the Maquette, a model map commissioned by Rennes priest Sauniere two years before his death in 1917. Entitled 'Jerusalem', and we have one in Lincoln, it comfortably fits the topography of the area involving the Cathedral and our marker tomb. A strange painting. 'The Invocation', left in the Museum of Antwerp also affords visual clues that pinpoint our location, as does a mysterious document simply entitled 'Wyville' deposited in Grantham Library in Lincolnshire that has been there for as long as the library's history can recall, the benefactor unknown.'Wyville' is a Masonic play on word revealing 'Wife Hill' the spot where our Quest concludes…the hill where hides the remains of the wife of Jesus?
'The Invocation'
Sauniere's Maquette overlays Lincoln
The plot thickens, for in 1995 the then Dean of the Cathedral Brandon Jackson (whose surname shares the strangely adjoining tomb to our marker), announced nationally that he thought the Cathedral, damaged by fire in 1141 and almost destroyed by an earthquake in 1185, was the battleground of Good and Evil and wanted it closed for three months to have it exorcised! In 2008 author and mathematician Greg Rigby orientated and aligned the Cathedral for me with star maps to discover it has an on ground relationship with the star Arcturus, the heavenly body that is the home of Arthurian legend, its name the origin of 'Arthur'. The Rose Window situated at the North side of the Cathedral (when all other Gothic Cathedrals have theirs at the west) is actually a Star Clock of the Northern heavens of which Arcturus features. Given this revelation, it may be clearer why the Very Reverend Alec Knight, Dean of the Cathedral in 2004, had a winking figurehead of himself carved and placed around the Rose Window Tracery 85' above the ground and around its stained glass, for the Masonic understanding of a 'wink' is an informal mode of communication indicating shared, secret knowledge.
The winking Dean high up the Star Clock Rose Window
Further appearances of sacred geometry appeared when astonishing alignments came to light when my friend Tony Peart and his templarmechanics.com/ Sacred Geometry website announced that churches south of Lincoln sit on pagan sites that form a mystical pentagram and that the Templars had built their headquarters at Temple Bruer as part of it, physical manifestations in the area, both natural and man made, affected by its geometrical dimensions. The remains of this 13c Templar Preceptory house on the west wall a peculiar etching that is at the top left of one of the two Rennes Parchments. Peart has also demonstrated a clear connection geometric between Bruer and Rennes-le-Chateau. In 2002 international stone sculptor Michael Dan Archer who has told me he receives his inspiration for his talent through dreams, positioned a sarcophagus shaped slab outside of the Great East Window home to the dog on the plate, randomly pointing over to our marker tomb. Unwittingly, he chose a most fascinating title for this work. He named it 'The Secret'!
Michael Dan Archer's 'The Secret' faces the burial grounds
In 2006 the Chief Executive of the Cathedral announced publicly that there would be no problem allowing my request for a GPR radar scan at my marker tomb location – I was paying for it myself and it involved no structural damage. When the time drew nearer for the scan, the Cathedral reneged and a strange silence on the matter followed and remains. Even the Archbishop of Canterbury cannot overturn any decision made by a Cathedral, as I learned when I put my case to him. However, a German geophysicist and a well-known Rennes researcher, both wishing to remain anonymous, carried out their own scan at the site in April 2011 and a sarcophagus shaped anomaly alongside a metal oblong anomaly were detected. (see Youtube 'The Lincoln Cathedral Code GPR Scan 2011')
Being led to a 'lost' historical artifact of the Knights Templar is only half of this ongoing story. Wrapped up in the symbology of the Grail as it is perceived today, a mystery involving Mary Magdalene, this 'treasure' appears to await us under tomb 28 at the burial grounds of St Margaret opposite the SE corner of Lincoln Cathedral. French aristocrat Marie de Negre, who is universally believed to have guarded the secret of Rennes, died in 1781…the very year that the church of St Margaret that housed the spot under the ground where our marker tomb stands, was demolished. When I decoded De Negre's complex cryptic headstone, it read' Margaret at Lincoln'. Is it the mysterious Magdalene, the contemporary Grail, who awaits discovery? Is this 'treasure' the object of a battle between two opposing forces?
'Margaret at Lincoln' – The complex de Negre code broken
An 1850 painting in the Cathedral by an ex member of the Royal Academy of Art famed for his canvasses of salacious women, Matthew William Peters, who became Canon at the Cathedral, shows a red haired, red garbed pregnant woman. The scene is supposed to be of the Annunciation, but clearly the figure depicts the sacred feminine associated with the Magdalene, an observation agreed with me by the respected authoress Margaret Starbird. The woman looks over at a small black monolith that resembles our marker tomb. On it lays something resembling scrolls. Does the remains of Mary, documentation and some shocking secret await discovery under the tomb? My own enforced conclusion is presented in the USA movie docu 'The Murder of Mary Magdalene; Genocide of the Holy Bloodline'.
On November 23rd 2011 something quite unexpected and alchemically significant occurred when for 48 hours only the mystical archetype of the Chartres labyrinth was chalked on the stone floor of Lincoln cathedral exactly in the middle of both opposing Light and Dark Rose Windows, at the area called The Crossing. The centre of the labyrinth is known as 'The Temple of Jerusalem'.
Alchemical Chartres Labryinth Mandala arrives inside Lincoln Cathedral
Then in 2012 another global icon announced it would be visiting Lincoln to brush past the Cathedral code marker tomb….the Olympic Torch. The blazing torch is a symbol of the Greek archetype Hecate Goddess of the Underworld whose presence is associated with entrances, tombs and burial grounds, and so it comes as no surprise that her torch will pass by the Cathedral Code marker tomb and burial grounds of St Margaret's. The synchronicities unfold when we learn that the torch will be carried into Lincoln Cathedral to stay overnight on 28th June, that reoccurring number associated throughout the Code. Even more intriguing is that the surname of the Masonic number and 33 year old carrier is HOPE. This is most interesting from the point of why should the bearer, of all names, that is passing by our marker tomb express an etymology that can be traced back to a Germanic word from the Dutch 'hopen' – phonetically 'open' – meaning a desire of good with some expectation of fulfillment? Is our tomb destined to be opened ? There is another number associated with our Code mystery that has been deduced by American author Gary Val Tenuta by exploring the notion that our English alphabet is encoded to synchronise with the numbers 1 through to 9, useable as a form of Geomatria. This find is to use the basic single digit numerology that is part of Ross Kelly's 'Ana Code' (see 'Synchronicitywins.blogspot.com/') 151 is the key number Kelly's Code is based around and his principle figure, the female 'Ana' or Isis, has the value 151. Using Tenuta's findings, both Rennes-le-chateau and Lincoln Cathedral, as well as numerous Templar related words and short phrases, have a value of 151. If we accept the date 11 -23-11 for when the Chartres Labyrinth arrived within Lincoln Cathedral we find the total 151 hides itself right in the centre – 11 2+3 11
Hecate of the burial grounds and tombs holds her torch
The geometry discovered by Tony Peart's Templar Mechanics has shown that the key measurement is 5.15 miles, a simple reassembly of 151. When I paid a visit to 192.com a site that finds how many people they could find with the surname Kelly, it came up with exactly 151 people named Ross Kelly. Studying Kendrick's 1928 famed and voluminous book of Lincoln Cathedral looking for a ground plan, I found only one. It is figure 151! The reason I mention the 151 association becomes clear when we follow the Olympic torch out of Lincoln where it next heads to the Major Oak in Sherwood Forest, the handover from one torchbearer to another taking place at 11:11am, 11:11 being a noted phenomenon associated with synchronicity. The Major Oak is a huge oddly shaped oak tree which according to local folklore was Robin Hood's shelter where he and his merry men slept. Robin has a strong connexion with Lincoln in that Lincoln green is the colour of the dyed woolen cloth worn by Robin and his men, produced by the dyers of Lincoln. However, did the enigmatic figure of Robin ever really exist and the same can be asked of his alleged wife Maid Marion, she of the same initials of Mary Magdalene? There is a very strong indication that throughout history, perhaps inspired by the meanderings of the Collective Unconscious, couplet myths have maintained the indication that once there were an original male and female of great significance, Isis-Osiris and Mary Magdalene-Jesus being two examples and forerunners to Robin and Marion, for each generation appears to have them to keep the burning flame of memory alive. Whether all these couples actually existed as recorded or where partly myth or archetypical is a moot question. The fact remains that we have them in our memory for our own investigations.
The Sherwood Forest Pentagram with the Major Oak at the centre
Jerusalem's Well
When the torch heads for the Major Oak the flame is carried by five people all with surnames relevantly significant to our Cathedral Code: SHEPPARD, FOOTE, WILLIAMS, and particularly so, GRAVES and CHAMBERS. In Poussin's 'Shepherds of Arcadia' the shepherd nearest to the Shepherdess has his foot placed on a noticeably and strategic small raised rock, the same theme duplicated with the Lincoln Imp's placing of his 'v' notched left leg. The Archbishop of Canterbury, head of the church in England is of course Rowan Williams. A trusty correspondent of mine bought to my attention their 'Sherwood Forest Pentagram' with the Major Oak at its centre, nearby the landmark are two place names close to one another that return us to our peculiar Holy Land associations, with 'Jerusalem Well' and 'Jerusalem Plantation'. There is a recent post to mark the site of the well, filled in decades ago, records attesting to its very ancient history and the rumour that it served as a watering hole for the Crusades on their way to the Middle East. Neither historians nor the Forestry Commission, can explain how Jerusalem Plantation got its name. Indications are, led by the Collective Unconscious, the Lincoln leg of the Olympic Torch is following an old Templar/Pilgrim pathway. Perhaps, the route that furtively brought the mystery of Mary Magdalene, whatever that may be, to its final resting place?
Oh, and if you add the ages of the five torchbearers for this leg of the journey, would you be surprised to learn that it is 151?
Shepherds of Arcadia, the foot placed on the rock
The Lincoln Imp places his foot upon the rock
Filed Under: Dan Green, Guest Authors, Mystic Places, Strange Artifacts Tagged With: Da Vinci Code, Dan Brown, Dan Green, Lincoln Cathedral Code, Mary Magdalene, Olympic Torch, Templars, wife of Jesus
Ghys says
The 'tomb' on 'the the 'sheperds of arcadia' painting, showing through the shadow a secret relationship; the right boy born out of the Lady (Solomon & Makeda& Menelik?).
The location at Serres, S-Fr ( Pech Cardou, mountain known by those who're seeking the Inner Grale).
The right boy making a cross with his arm and leg, pointing at the boy on the left (Joseph??) This man obviously wears a crown of thorns (not Jesus but his son???)
Cathar philosophy – reincarnation, multidimensional painting
The Shadow on the tomb showing a Heart as well; there's a lake near Lincoln having the same form – there's an island: the not shadowed area in the heart??
By the way: as the mountain showed me ( through Isis?) 'horrible things happened here'…
A King at Rennes-Le-Chateau received an Arabian or Ethipian queen as well
The Shadow showing a squatting woman holding her lover's head (only the head!!); the right boy making a representationn of the decapitated boy on the right (with his staff)…
Dan Green says
Just thought I'd add that when the torch headed out of Lincoln it was halted by a lightning strike when the bearer's name was Chambers…
Ab Asaff says
This is an intriguing article that is of an archetypal and certainly a mythological nature. Historically, both mythology and archetypes have always aided humans in progressive spiritual evolution. A society without these two important factors is spiritually stagnated which has proven itself in this egocentric materialistic modern world void of the mythic adventure found in the above article. With Hollywood, computers and mindless violent electronic games and all the instant technology, humanity has lost its grand imagination and intuition and become egotistic selfish left brain ideologists deluded with illusions of imperial all knowing scientific grandeur.
Kudos to Dan Green for working to keep the spirit of the Mythical Quest alive in a world that is void of myth, magic and adventure.


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Friday Close-Up: Masala Baby
Nicole Feliciano
Had enough of the snow? Masala Baby will have your thinking spring. Dipali Patwa is the President and designer behind this colorful collection of kids' clothing. Modern, spirited, with the essence and traditions of India, this new line of pint-sized fashions caught our attention when we craved a break from boring black and gray. We've got the scoop on the inspiration and aspirations of Dipali.
Tell me about the inspiration behind the colors in masala baby?Masala, transliterated, is a combination of unique ingredients to create a surprising result - a pinch of turmeric, a dash of cloves, a sprig of saffron, and a handful of rose petals provide the inspiration for our signature "spice" colors, all beautifully layered as in the threads of this new collection. They were inspired by my roots in India; delicious curries, authentic spices, bollywood movies, beautiful marigold flowers, traditional indian roses, pink stone architecture, colors of the chaotic bazaars all blended together to create a unique palette. Kids respond to color instinctively. The rhapsodic use of color in India in brightly painted streets, mosaics of the palaces, the vivid hues of the women's sarees, the variety of spices used in Indian cooking and the exuberance of Indian festivals, the Indian love of color is celebrated in every facet of daily life. India's textile tradition is a kaleidoscope of colors and cultures.
I love the images on the web. Who did your photography? My friend and an incredible photographer- Franco Vogt of Woodstock Picture Studio did all the photography.
Where do you find your yummy models? They are delicious, aren't they! They all have been my inspiration along with my main inspiration, my son Elan. Some of them are his friends and couple of them that Franco was able to scout for us up in Woodstock for what we needed for the brand
What are the most popular styles from the spring line? Gypsy Raani Dress, Raani Medallion Tunic Dress, White Peacock Tunic, Desert Camel Stripe Tunic, Evening Sun Stripe Tunic, Dev Embroidered Tunic, Folk Skirt
What does the name mean? Masala, transliterated, is a combination of unique ingredients to create a surprising result. It is mainly used for spices when they are blended together to create an incredible flavor and aroma. It is also used to describe bollywood films which mixes various genres in one film- action, comedy, romance, musical all in one film.
For Masalababy, a pinch of turmeric, a dash of cloves, a sprig of saffron, and a handful of rose petals provide the inspiration for our signature "spice" colors. It is a mix of all things wonderful that come together in its own unique fashion.
Where do you live and what do you love about your neighborhood?We live in Park Slope, Brooklyn, NY. We love the fact that the neighborhood is ethnically diverse, culturally vibrant with lovely local boutiques, cafes and restaurants that are all very kid friendly. We like the combination of urban, cosmopolitan attitude with a neighborhood vibe
Favorite place for a cultural nyc playdate? Prospect Park summer time concerts that gives us a wide variety of music, dance, theater, film to experience from around the world in a wonderful outdoor relaxed atmosphere. Events at BAM- Brooklyn Academy of Music.
What are you working on next? For 2010 our key focus will be to enhance the Masala Baby brand and establish a greater retail presence with the launch of our new Fall 2010 line that includes two new collections.
The first is called 'Mela', inspired by the Indian village fairs. Mela is the Hindi word for 'gathering or village fair. The line is inspired by wandering gypsies, fortune tellers, colorful caravans, medallions and peacock feathers which set the mood for our patterns and colors. The cuts and designs are earthy, comfortable yet chic, catering to the new age young traveler that appreciates the simplicity and wonder of life.
The second collection called 'Mod Masala' is urban, modern and casual using our signature prints and unique applique techniques. We are introducing 'khadi' which is indian homespun, handwoven fabric within this collection. Its natural properties keeps this fabric cool in the summer and warm in the winter. Mahatma Gandhi promoted the production of khadi in his movement to revive India's domestic weaving industry. This fabric is close to my heart for its aesthetic appeal as well as the small scale industry that it supports back in India.
Masala baby is also proud to collaborate with aden + anais (australian swaddle company) on the introduction of 'Mela' bamboo muslin wraps. Mela is inspired by the fun and festivities of indian village fairs. Motifs such as marigold flowers, medallion inlay and the beautiful peacock feathers unfold on to these soft to touch bamboo wraps. The distinct aesthetic of Masala Baby and use of signature spice colors capture the brilliance of everyday life!
Momtrends readers save 20%! Use discount code- 'friends'
Plus free shipping for orders over $75. Discount code- 'freeship'
www.masalababynyc.com


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  } else if (query instanceof lf.query.SelectContext) {
    generator = new lf.proc.SelectLogicalPlanGenerator(query);
  } else if (query instanceof lf.query.UpdateContext) {
    generator = new lf.proc.UpdateLogicalPlanGenerator(query);
  } else {
    // 513: Unknown query context.
    throw new lf.Exception(513);
  }

  var rootNode = generator.generate();
  return new lf.proc.LogicalQueryPlan(rootNode, query.getScope());
};


text:
Research and Talks
…our general research interest
…methods that we established
…our funding sources
…recent and upcoming talks of Harald
OUR RESEARCH INTEREST
Our work lies at the interface of synthetic biology and mammalian physiology in the new research field synthetic physiology. The past decades have seen the emergence of synthetic biology, and with its paradigm 'build to understand', synthetic biology has proven to tackle the most complex biological problems. We are exploring synthetic principles for understanding and manipulating animal physiology. In past few years, our focus was on the 'synthetic' of synthetic physiology and we established new methods to control the signaling and behavior of nerve cells, cancer cells and key cell populations involved in metabolism. Our methods offer spatial and temporal precision and included but were not limited to optogenetics. We are currently transitioning to the 'physiology' of synthetic physiology with a focus on understanding/manipulating cell signaling and cell behavior in tissues affected by degeneration. Our interdisciplinary research builds on the development of new molecular tools and their applications in animal models (mouse and Drosophila) of disease.
You can download Harald's Biosketch here.
Click here for a list of recent and upcoming presentations of Harald.
Cell proliferation and survival in degenerative disorders
Cell survival and proliferation are stringently regulated in all organisms and dysregulation towards too much cell death or too much cell growth can be equally fatal. Cancer is the most prominent disease characterized by uncontrolled cell growth, while many disparate diseases, including Type I and Parkinson's disease, are characterized by excessive cell death. Growth factors are capable of activating pro-survival and proliferative pathways in cells affected by excessive disease-related death (e.g. pancreatic beta-cells, dopaminergic neurons and spinal cord neurons), but difficulties and concerns in using growth factors as research tools and in translation remain. Many growth factor receptors have widespread tissue distribution and thus systemic administration results in undesired signaling and toxicity in cells other than those targeted. In addition, many growth factors exhibit limited half-life in the circulation and cannot be delivered to some critical tissues (e.g. the brain). Finally, growth signals delivered by gene therapy are stationary and permanent. For these and other reasons, it is currently not possible to selectively and reversibly regulate the survival and proliferation of specific cell populations in a tissue or organism. We tackle this challenge by exploring new synthetic strategies for site-targeted administration of pro-survival and proliferative signals. In light of the known efficacy of growth factors but confronted with the above challenges, the new strategies may in the future be applied to control survival and proliferation of cells ex vivo or in translation.
Function and physiology of orphan receptors
Many membrane receptors are classified as 'orphans' because limited information is available on their ligands, coupling to the cellular signaling machinery and physiological functions. Many orphan receptors are conserved across species, strongly suggesting the existence of physiological functions, and orphans have been implicated in a variety of dysfunctions, including cancer, metabolic disorders and brain disorders. Currently, it is not possible to activate orphan receptors in situ and in real time and consequently at least two major questions remain: (i) Do orphan receptors couple to canonical cellular signaling pathways? (ii) What are the physiological roles of orphan receptors in health and disease? We tackle these questions based on the hypothesis that 'functionalized' orphan receptors, in which activation by an unknown ligand is replaced with that of a known stimulus, enable probing their function in cells and animals models. This work shines light on one of the longest-standing problems in physiology by revealing new biological insight on the signaling function and physiology of orphan receptors (this information will be valuable in basic research and drug discovery) and by providing chemical-genetic and optogenetic approaches to activate receptors in the absence of ligands (conventionally, ligands are considered essential for experiments with receptors). In our all-optical drug screen (see below), we already identified a drug candidate targeting an orphan receptor tyrosine kinase that is implicated in non-small cell lung cancer.
– Our paper on light-activated GPCR signaling in Nature Communications 2018
– Identifiers and sequences of light-activated variants of 63 understudied and orphan GPCRs can be found in Nature Communications 2018 Supplementary Table 3 and Supplementary Data 1 to 4
– Our modified Golden Gate cloning procedure and the corresponding expression vectors can be found in Nature Communications 2018 Supplementary Figures 1 and 2 and Supplementary Tables 4 and 5
– Available genes and construct information can be found here, including light-activated variants of nine prototypical GPCRs that served as controls
– Our Current Opinion 2019 on the design of GPCRs with new functions
All-optical drug discovery
Already some years ago we and others have proposed that the non-invasive nature of optogenetics may be exploited to create new experimental paradigms in systems biology and small molecule screening. In both cases the use of optogenetics was suggested for creating more powerful, more reproducible and more economic high-throughput cellular assays. We recently demonstrated the first of these optogenetics-assisted small molecule screening methods. In our 'all-optical' screen, light acted both as activator and read-out to obviate the use of assay chemicals (e.g. peptide ligands or reagents for read-out), to limit the number of required operational steps (e.g. solution exchange or other invasive actions using robotics) and to improve specificity. In our first screen, we identified AV-951 (Tivozanib) as a potent and selective inhibitor of ROS1, an orphan kinase that we activated using light in the absence of the unknown ligand. Our method can be easily adapted to many drug targets and cellular processes because of the many optical control tools available (see below for a link to a review of Mueller and Weber) and we are excited to do this in the future also with new partners.
– Our Current Opinion 2017 with Viviana Agus from Axxam S.p.
– A recent Methods 2020 paper with with Viviana, specifically in the context of ion channels
– Our paper in Nature Chemical Biology 2015
– Our bioinformatics procedure to identify orphan (receptor) tyrosine kinases can be found in the Nature Chemical Biology 2015 Supplementary Figure 7 and Supplementary Table 2
– Press coverage and articles about this work can be found here
Sensors for neurotransmitters and synthetic neurotransmission
Our work in the context of our HFSP Young Investigator grant focused on understanding and manipulating neurotransmitter signaling. Historically, acetylcholine was the first chemical neurotransmitter to be synthesized, and it was shown to activate cells about sixty years before the genetic identity of acetylcholine receptors was revealed. While the components of chemical neurotransmission have been at least in part demystified in the past, an on-going challenge is to more sensitively detect neurotransmitter signaling, e.g. using optical sensors, and to create orthogonal neurotransmitter systems that will allow manipulating neural circuits in a manner that strictly relies on synaptic connectivity and activity. We address these two challenges in ongoing collaborative work with Christian Henneberger's (University of Bonn) and Colin Jackson's (Australian National University) lab.
– Our recent collaborative paper in Nature Chemical Biology 2018
– Our series of articles in the Synthetic Protein Switches 2017 issue of Methods in Molecular Biology and in ACS Sensors 2017
– Our first joint paper in Protein Science 2015
– The webpage of our collaborator Colin Jackson (Australian National University)
– The webpage of our collaborator Christian Henneberger (University of Bonn)
ESTABLISHED METHODOLOGICAL FOUNDATION
Light-controlled receptor tyrosine kinases (Opto-RTKs)
Optogenetics has revolutionized the field of neuroscience and is starting to have a big impact on cell and developmental biology as well. Advantages of optogenetics include the ease with which signals can be applied and withdrawn and the ability of rapid and local signal activation. Complementary to light-sensing ion channels and ion pumps, we developed light-activated receptor tyrosine kinases, such as Opto-FGFR1 or Opto-EGFR, the light-activated fibroblast growth factor receptor 1 or the light-activated epidermal growth factor receptor, along with light-activated neurotrophic factor receptors, as well as a light-INactivated fibroblast growth factor receptor 1. In cells expressing these receptors, light controls signaling with spatial and temporal precision and faithfully mimics complex mitogenic and morphogenic cell behavior. The receptors are available here. We are currently continuing this project in many directions by both further engineering as well as applying the receptors to selected questions in physiology.
– Our papers in EMBO Journal 2014 (blue light), Angewandte Chemie Int. Ed 2016 (red light) and Angewandte Chemie Int. Ed 2017 (green light INactivated)
– Our perspective in Molecular and Cellular Oncology 2015
– Press coverage and articles about this work can be found here (blue light), here (red light) and here (green light)
– Interview with Harald in LabTimes 2014
– Available genes and construct information can be found here
Light-induced homodimerization of receptors and other proteins
While working on the Opto-RTKs project, we have identified through database and literature searches LOV domains that change oligomerization state in response to blue light stimulation. The proteins allow for in vivo spatio-temporally precise regulation of many dimerization reactions in response to blue light with different lifetimes and dissociation constant. The domains are available here, along with the red-light induced homodimerizing phytochrome sensory domain.
– Our JMB 2019 paper describing a useful vector collection
– EMBO Journal 2014 supplement Table S1, S2 and S4
– A modified Table S1 for the blue light-activated proteins with estimated, in vitro dissociation constants and additional references can be found here
Optogenetics meets analytical chemistry
All optogenetic tools require chemical co-factors (e.g. flavins in LOV domains, retinal in opsins or tetrapyrroles in phytochromes) for light sensing, but surprisingly the quantity and distribution of these molecules in cells and tissues are poorly understood, even for those molecules that are present in all cells. To address this, we started a new line of research that combines analytical chemistry with optogenetics. In our first study, we quantified flavin contents in different cell types using a modified, LED-based capillary electrophoresis technique. We found that free flavin contents were limited and are potentially limiting in optogenetic experiments and other synthetic biology studies that express flavin-binding proteins. We are now expanding this line of research to the other co-factors and we explore how co-factor household is regulated.
– Our paper in Electrophoresis 2015
– Wikipedia.org reference to our paper, e.g. here
REAGENTS AND COLLABORATIONS
We believe in sharing of published but also unpublished materials without strings attached. Have a look at our genes and reagents here and drop us a line if you think we might have something that is useful for your research (even if it is not listed on that page).
"Lights will guide you home." – Coldplay
Our common research goal is to shed light on biological signals with the help of synthetic molecular torches. Each of us contributes a unique background ranging from biology to neuroscience, physics and chemistry. This enables us to design novel and multidisciplinary ways to approach classic problems in cellular signaling in mammalian systems. As an international group we work together following principles of collegiality by supporting each other to achieve our goals. Our dedication to research builds on the desire for innovation and intellectual curiosity.
OUR RESEARCH IS CURRENTLY FUNDED BY…
EMBL Australia
Australian Research Council (ARC)
National Health and Medical Research Council (NHMRC)
IN THE PAST, OUR RESEARCH WAS FUNDED BY…
The Juvenile Diabetes Research Foundation (JDRF)
European Union Seventh Framework Programme (FP7)
Human Frontier Science Program (HFSP)
Austrian Science Fund (FWF)
Austrian Research Promotion Agency (FFG)
Austrian Academy of Sciences (OEAW)
Dan David Foundation
Ramon Areces Foundation
RECENT AND UPCOMING INVITED PRESENTATIONS
2019, November 29, Neuroplasticity – Systems, Synapses and Tools Symposium, Hobart, TAS
2019, October 3, Charles Perkins Centre, University of Sydney, NSW
2019, September 20, University of New South Wales, Sydney, NSW
2019, September 8-13, 13th Australian Peptide Conference, Port Douglas, QLD
2019, May 3, Baker Heart and Diabetes Institute, Melbourne, VIC
2019, April 30, Department of Diabetes, Monash University, Melbourne, VIC
2019, April 16, St Vincent's Institute of Medical Research, Melbourne, VIC
2018, November 30, 11th Australian Islet Study Group Meeting, Canberra, ACT
2018, October 25&27, International Symposium on Growth Factors in Disease and Therapy, Hangzhou and Wenzhou, China
2018, October 2, Genetic Manipulation of Neuronal Activity V, Janelia Farms, VA
2018, September 20, Science without borders symposium, EMBL Heidelberg, Heidelberg, Germany
2018, July 15, Chinese University of Hong Kong, Hong Kong SAR
2018, June 20, Baker Heart and Diabetes Institute, Melbourne, VIC
2018, March 25, Gordon Research Conference on Fibroblast Growth Factors in Development & Disease, Ventura, CA
2018, March 22, School of Medicine, University of California Davis, CA
2018, March 20, Department of Chemistry, Stanford University, CA
2018, March 5, Gordon Research Conference on Photosensory Receptors and Signal Transduction, Il Ciocco, Italy
2018, February 5, The 43rd Lorne Conference on Protein Structure and Function 2018, Lorne, VIC
2017, December 5, The VIP-PACAP Congress 2017, Hong Kong SAR
2017, November 30, Molecular Health Sciences, ETH Zurich, Zurich, Switzerland
2017, September 14, With new molecular probes and modulators towards novel pharmacological concepts, Bonn, Germany
2017, September 1, Design and Light Control, Frankfurt, Germany
2017, August 27, Paul Ehrlich Symposium, Vienna, Austria
2017, August 24, International Biophysics Summer School, Kleinwalsertal, Austria
2017, August 22, 26th ISN-ESN Biennial Meeting, International Society for Neurochemistry, Paris, France
2017, April 6, 14th Life Science meeting, IMC University of Applied Sciences, Krems, Austria
2017, April 13, Neuronal Patterning and Connectivity, Center for Molecular Neurobiology, Hamburg, Germany
2016, December 15, BioMedX, Heidelberg, Germany
2016, December 8, iBV CNRS INSERM, Université de Nice Sophia Antipolis, France
2016, October 19, Genetic Manipulation of Neuronal Activity IV, Janelia Farms, VA
2016, October 5, 17th International Conference on Retinal Proteins, Potsdam, Germany
2016, September 21, Pharmacology of 7TM-receptors and downstream signaling pathways, Bonn, Germany
2016, July 16, A Passion for Proteins: From Structure and Folding to Understanding and Design, Bayreuth, Germany
2016, June 8, From Solid State to BioPhysics VIII, Dubrovnik, Croatia
2016, March 24, Faculty of Health Sciences, University of Macao, Macao SAR
2016, March 21, School of Aerospace, Mechanical and Mechatronic Engineering, University of Sydney, NSW
2016, March 14, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, VIC
2016, January 28, Modern Concepts in Structural Biology, Vienna Biocenter, Austria
2015, December 1, bioss – Centre for Biological Signalling Studies, Freiburg, Germany
2015, September 24, Ludwig Institute for Cancer Research, Oxford, UK
2015, July 1, Institute of Chemical Biology, University of Vienna, Austria
2015, June 9, Signal Processing in Neurons (SPIN), Innsbruck, Austria
2015, March 20, Bordeaux Neurocampus, France
2015, March 3, Medical University of Graz, Austria
2014, October 15, University Hospital Heidelberg, Germany
2014, October 14, European Molecular Biology Laboratory, Heidelberg, Germany
2014, September 26, Beilstein Conference on Molecular Switches, Chiemsee, Germany
2014, September 12, 16th International Congress on Photobiology, Cordoba, Argentina
2014, June 9, Salk Institute for Biological Studies, CA
2014, June 6, University of California Irvine, CA
2014, May 7, Casimir Spring School, Arnemuiden, Netherlands
2014, February 4, CIM IMPRS, Münster, Germany


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Quran: [17:36] "You shall not accept any information, unless you verify it for yourself. I have given you the hearing, the eyesight, and the brain, and you are responsible for using them."
Quran: [49:12] "O ye who believe! Avoid suspicion as much (as possible): for suspicion in some cases is a sin: And spy not on each other behind their backs. Would any of you like to eat the flesh of his dead brother? Nay, ye would abhor it...But fear Allah. For Allah is Oft-Returning, Most Merciful."
Surah 101. Al-Qariah Translations of the Qur'an. Chapter 101: AL-QARIAH (THE CALAMITY, THE STUNNING BLOW, THE DISASTER, THE SHOCKER). Total Verses: 11. Revealed At: MAKKA. Order in which revealed: 30.
Ah, what will convey unto thee what the calamity is!
And the mountains will become as carded wool.
He will live a pleasant life.
The Bereft and Hungry One will be his mother.
Ah, what will convey unto thee what she is!
Quran.Mu 2012 | Royal Road Tyack Riviere Anguilles. MAURITIUS.