text:
The chemical reactivity of a known anti-psoriasis drug. Part 1: Further insights into the products resulting from oxidative cleavage
Magali M. Lorion, Tomas Lebl, Alexandra M Z Slawin, Douglas Philp, Nicholas J. Westwood, Alan Jones
The oxidative cleavage of the known anti-psoriasis drug 1 to give 2 has been reported previously. Due to the importance of accessing medium-sized ring containing systems via oxidative cleavage, this reaction has been revisited revealing additional information about the structure of 2. Alternative reaction products were identified when the reaction was carried out in the presence of water. The conversion of 1 to 2 has also been carried out using ruthenium tetroxide. A detailed variable temperature NMR and computational study of the restricted rotation of the N-aryl ring in 2 is presented.
https://doi.org/10.1016/j.tet.2010.10.044
Heterocycle
Macrocycle
Oxidative fragmentation
VT NMR analysis
10.1016/j.tet.2010.10.044
Dive into the research topics of 'The chemical reactivity of a known anti-psoriasis drug. Part 1: Further insights into the products resulting from oxidative cleavage'. Together they form a unique fingerprint.
ruthenium tetraoxide Medicine & Life Sciences 100%
Antipsoriasis Chemistry 91%
Oxidative Elimination Reaction Chemistry 60%
Chemical Reactivity Chemistry 52%
Psoriasis Medicine & Life Sciences 49%
Restricted Rotation Chemistry 33%
Water Medicine & Life Sciences 33%
Lorion, M. M., Lebl, T., Slawin, A. M. Z., Philp, D., Westwood, N. J., & Jones, A. (2010). The chemical reactivity of a known anti-psoriasis drug. Part 1: Further insights into the products resulting from oxidative cleavage. Tetrahedron, 66(51), 9667-9674. https://doi.org/10.1016/j.tet.2010.10.044
Lorion, Magali M. ; Lebl, Tomas ; Slawin, Alexandra M Z et al. / The chemical reactivity of a known anti-psoriasis drug. Part 1 : Further insights into the products resulting from oxidative cleavage. In: Tetrahedron. 2010 ; Vol. 66, No. 51. pp. 9667-9674.
@article{2c0d463254e84729b5a1aeecee60ed64,
title = "The chemical reactivity of a known anti-psoriasis drug. Part 1: Further insights into the products resulting from oxidative cleavage",
abstract = "The oxidative cleavage of the known anti-psoriasis drug 1 to give 2 has been reported previously. Due to the importance of accessing medium-sized ring containing systems via oxidative cleavage, this reaction has been revisited revealing additional information about the structure of 2. Alternative reaction products were identified when the reaction was carried out in the presence of water. The conversion of 1 to 2 has also been carried out using ruthenium tetroxide. A detailed variable temperature NMR and computational study of the restricted rotation of the N-aryl ring in 2 is presented.",
keywords = "Heterocycle, Macrocycle, Mechanism, Oxidative fragmentation, VT NMR analysis",
author = "Lorion, {Magali M.} and Tomas Lebl and Slawin, {Alexandra M Z} and Douglas Philp and Westwood, {Nicholas J.} and Alan Jones",
doi = "10.1016/j.tet.2010.10.044",
Lorion, MM, Lebl, T, Slawin, AMZ, Philp, D, Westwood, NJ & Jones, A 2010, 'The chemical reactivity of a known anti-psoriasis drug. Part 1: Further insights into the products resulting from oxidative cleavage', Tetrahedron, vol. 66, no. 51, pp. 9667-9674. https://doi.org/10.1016/j.tet.2010.10.044
The chemical reactivity of a known anti-psoriasis drug. Part 1 : Further insights into the products resulting from oxidative cleavage. / Lorion, Magali M.; Lebl, Tomas; Slawin, Alexandra M Z et al.
In: Tetrahedron, Vol. 66, No. 51, 18.12.2010, p. 9667-9674.
T1 - The chemical reactivity of a known anti-psoriasis drug. Part 1
T2 - Further insights into the products resulting from oxidative cleavage
AU - Lorion, Magali M.
AU - Lebl, Tomas
AU - Slawin, Alexandra M Z
AU - Philp, Douglas
AU - Westwood, Nicholas J.
AU - Jones, Alan
N2 - The oxidative cleavage of the known anti-psoriasis drug 1 to give 2 has been reported previously. Due to the importance of accessing medium-sized ring containing systems via oxidative cleavage, this reaction has been revisited revealing additional information about the structure of 2. Alternative reaction products were identified when the reaction was carried out in the presence of water. The conversion of 1 to 2 has also been carried out using ruthenium tetroxide. A detailed variable temperature NMR and computational study of the restricted rotation of the N-aryl ring in 2 is presented.
AB - The oxidative cleavage of the known anti-psoriasis drug 1 to give 2 has been reported previously. Due to the importance of accessing medium-sized ring containing systems via oxidative cleavage, this reaction has been revisited revealing additional information about the structure of 2. Alternative reaction products were identified when the reaction was carried out in the presence of water. The conversion of 1 to 2 has also been carried out using ruthenium tetroxide. A detailed variable temperature NMR and computational study of the restricted rotation of the N-aryl ring in 2 is presented.
KW - Heterocycle
KW - Macrocycle
KW - Mechanism
KW - Oxidative fragmentation
KW - VT NMR analysis
U2 - 10.1016/j.tet.2010.10.044
DO - 10.1016/j.tet.2010.10.044
Lorion MM, Lebl T, Slawin AMZ, Philp D, Westwood NJ, Jones A. The chemical reactivity of a known anti-psoriasis drug. Part 1: Further insights into the products resulting from oxidative cleavage. Tetrahedron. 2010 Dec 18;66(51):9667-9674. doi: 10.1016/j.tet.2010.10.044


text:
«Я́дерная триа́да» (от , род.п.  — «троица»; ) — общепринятый международный термин, обозначающий оснащённые ядерным оружием стратегические вооружённые силы государства, включающие в себя три компонента:
 стратегическая авиация
 межконтинентальные баллистические ракеты
 атомные подводные ракетоносцы.
Разделение стратегических ядерных зарядов государства между несколькими видами ядерных вооружённых сил стратегического назначения обеспечивает невозможность уничтожения всего боеспособного арсенала ядерного оружия в случае внезапного нападения противника и предоставляет большую гибкость в его применении. Даже при полном уничтожении арсеналов двух любых компонентов, третий должен быть способен нанести ответный удар, гарантирующий уничтожение противника или причинение ему неприемлемого ущерба.

Классическая «ядерная триада»
Классическая «ядерная триада» состоит из сухопутного, морского и воздушного компонентов. Считается, что полноценной ядерной триадой в XX веке обладали имевшие ядерный паритет сверхдержавы СССР и США, и в настоящее время (с 1991 г.) из всех ядерных держав ядерной триадой обладают только США и Россия.

Тактические ядерные заряды не входят в ядерную триаду, так как не предназначаются для использования в нанесении «второго удара».

Компоненты

Сухопутный
Межконтинентальные баллистические ракеты (МБР) стационарного и мобильного базирования являются главным компонентом стратегических ядерных сил. Малая уязвимость МБР обеспечивается за счёт высокой защищённости стационарных шахтных пусковых установок, способных выдержать близкий (до нескольких сотен метров) ядерный взрыв средней мощности и рассредоточения их на местности. Мобильные грунтовые и железнодорожные пусковые установки способны быстро менять позиции и маневрировать в пределах всей дорожной сети страны, что затрудняет их обнаружение и уничтожение.

Морской
Основным носителем межконтинентальных баллистических ракет на флоте являются атомные подводные лодки. Они имеют большой срок автономности и способны скрытно маневрировать в пределах всего мирового океана и проводить запуски ракет из подводного положения, а также всплывая из-подо льдов Северного Ледовитого океана, что делает их обнаружение и уничтожение до момента запуска ракет очень сложной задачей. Существуют подводные лодки, способные нести до 24-х МБР с четырнадцатью боевыми частями индивидуального наведения каждая (лодки типа «Огайо»), что делает даже одиночную подводную лодку крайне опасной.

Некоторые надводные корабли также способны нести крылатые ракеты с ядерными боевыми частями.

Воздушный
Носителем крылатых ракет воздушного базирования с ядерными боеголовками и ядерных бомб являются стратегические бомбардировщики, способные совершать дальние перелёты и длительное время находиться в воздухе на патрулировании, в том числе и возле границ потенциального противника. Это даёт возможность политического давления на противника, обеспечивает быстрое нанесение удара в случае начала войны. Также достоинством таких бомбардировщиков является возможность оперативного манёвра силами и поражения цели практически в любой точке мира.

«Ядерная триада» России
«Ядерную триаду» России, согласно актуальному составу стратегических ядерных сил Российской Федерации, составляют:
 ракетные войска стратегического назначения Российской Федерации (РВСН),
 морские стратегические силы Российской Федерации,
 стратегическая авиация Российской Федерации.

По состоянию на 1 октября 2016 года в боевой состав ракетных войск стратегического назначения России (РВСН) входит около 300 ракетных комплексов, способных нести более 1000 ядерных боевых зарядов. На боевом дежурстве РВСН находятся: 46 тяжёлых ракет Р-36М2 (SS-18, Satan), 20 (30?) ракет УР-100Н УТТХ (SS-19), 72 подвижных грунтовых комплекса РТ-2ПМ «Тополь» (SS-25), 60 комплексов РТ-2ПМ2 «Тополь-М» шахтного базирования (SS-27), 18 мобильных комплексов РТ-2ПМ2 «Тополь-М» (SS-27), 78 мобильных комплекса РС-24 «Ярс» и 18 РС-24 «Ярс» шахтного базирования. Треть всех ракет — новейших типов, с дальностью 11-13 тысяч километров. Все МБР наземного базирования развёрнуты в позиционных районах одиннадцати ракетных дивизий трёх ракетных армий. Географически соединения ракетных войск России расположены таким образом, что никакой глобальный удар не может разом вывести из строя группировку РВСН.

С 2013 года в России началось обновление морского компонента «ядерной триады». 10 января 2013 года на вооружение ВМФ РФ были приняты новый стратегический атомный подводный крейсер «Юрий Долгорукий» (проекта 955 «Борей») и его основное оружие — межконтинентальная баллистическая ракета морского базирования Р-30 «Булава-30», 23 декабря 2013 года — вторая подводная лодка проекта 955 «Борей» «Александр Невский», 19 декабря 2014 года — третья АПЛ этого же проекта «Владимир Мономах».

Таким образом, в строю морских стратегических сил РФ по состоянию на 1 марта 2017 года находятся 13 атомных подводных лодок с баллистическими ракетами ПЛАРБ с 212 пусковыми установками, способных нести до 936 ядерных боевых блоков, из них боевое дежурство несут 10 ПЛАРБ со 160 носителями. Основу морских стратегических сил России составляют 5 ракетоносцев проекта 667БДРМ «Дельфин» (Delta IV), оснащённых 80 (16 х 5) пусковыми установками (ПУ) с баллистическим ракетами подводных лодок (БРПЛ) Р-29РМУ2 «Синева» (SS-23) и их модификацией Р-29РМУ2.1 «Лайнер», ещё одна подлодка этого проекта находится на плановом перевооружении. В строю остаются 3 подводные лодки проекта 667БДР «Кальмар» (Delta III), оснащённых 32 (16 х 2) ПУ ракет Р-29Р, причём одна лодка данного проекта прошла ремонт и модернизацию в 2011—2016 годах и вернулась в строй в феврале 2017 года. Также на боевую вахту заступили 3 подводные лодки проекта 955A «Борей», оснащённых 48 (16 х 3) ПУ со стратегическими ракетами Р-30 «Булава». Тяжёлый ракетоносец проекта 941 «Акула» (Typhoon) переделан под испытания ракет Р-30 «Булава». На ПЛАРБ размещено более 700 ядерных боевых блоков. Дальность ракет — 8-9,3 тысяч километров. К 2020 году основу морского компонента «ядерной триады» России составят восемь «Бореев» (на каждой — 16 БРПЛ «Булава»).

Стратегическая авиация «ядерной триады» России по состоянию на 1 мая 2017 года состоит из 60 стратегических бомбардировщиков Ту-95МС и 16 Ту-160, дислоцированных на трёх авиабазах. От других компонентов «триады» российскую дальнюю авиацию, называемую «длинной рукой», отличает гибкость применения, ведь перенацелить самолёт можно прямо в воздухе. В 2015 году пять «Ту-160» вернулись в строй обновлёнными, должны пройти модернизацию и все остальные боевые стратегические самолёты этой модели.

Министр обороны Российской Федерации Сергей Шойгу, выступая 11 декабря 2015 года на заседании расширенной коллегии Министерства обороны Российской Федерации, об оснащении «ядерной триады» России сообщил: «Доля современных вооружений в наземных стратегических ядерных силах составила 51 %. Авиационные стратегические ядерные силы в 2015 году пополнились десятью самолётами, из них два Ту-160, три Ту-95МС и пять Ту-22М3. Усилилась боевая мощь стратегических ядерных сил. В состав постоянной готовности введены два ракетных крейсера — "Александр Невский" и "Владимир Мономах". Всего в ВС РФ поставлено 35 баллистических ракет, что позволило добиться уровня оснащения современными вооружениями "ядерной триады" в 55 %».

20 декабря 2015 года президент Российской Федерации Владимир Путин в интервью Владимиру Соловьёву, показанном в документальном фильме Саиды Медведевой «Миропорядок» в эфире телеканала «Россия-1», по вопросу ядерного оружия сделал следующее заявление: «Как фактор сдерживания Россия, как одна из ведущих ядерных держав, будет это оружие совершенствовать… Ядерная триада лежит в основе нашей политики ядерной безопасности, но мы никогда не размахивали и никогда не будем размахивать этой ядерной дубиной, но в нашей военной доктрине ей отводится надлежащее место и надлежащая роль».

По данным Государственного департамента США, по состоянию на 1 марта 2017 года в составе стратегических ядерных сил России находилось 1765 ядерных боезарядов на 523 развёрнутых стратегических носителях, общее же количество носителей, развёрнутых и неразвёрнутых, составляло 816 штук.

«Ядерная триада» США
В течение 2020-х годов США намереваются формировать новую ядерную триаду, которая прослужит до конца XXI века.

2 февраля 2018 года Министерство обороны США опубликовало новую ядерную доктрину Соединённых Штатов Америки под названием «Обзор ядерной политики», исходя из которой США намерены продолжать предложенную в 2010 году бывшим президентом Бараком Обамой концепцию модернизации ядерных сил в связи с «развитием российского ядерного потенциала». Ключевые места в стратегии занимают также ядерные силы КНР, Ирана и КНДР.

В своём заявлении от 2 февраля 2018 года Президент США Дональд Трамп отметил:
«На протяжении последнего десятилетия, несмотря на попытки США снизить роль и арсенал ядерного оружия, другие ядерные державы наращивали свой арсенал, увеличивали значение ядерного оружия в своих стратегиях безопасности, а также — в ряде случаев — продолжали развивать новые ядерные возможности, чтобы угрожать другим народам. Последующие администрации США воздерживались от крайне необходимой модернизации ядерного оружия, инфраструктуры и средств доставки… Ядерная доктрина 2018 года направлена на то, чтобы справиться с этими вызовами».
Согласно этой новой ядерной доктрине, материально-техническую основу вновь создаваемой стратегической ядерной триады страны составят 400 моноблочных МБР наземного базирования, предположительно под названием «Минитмен-4», первая из которых появится в 2029 году, для размещения которых будет оставлено повышенное количество шахтных пусковых установок (450), что позволит рассредоточить этот компонент стратегических ядерных сил и создать до 50 ложных шахт под такие ракеты.

На начальном этапе в ядерную триаду США должны войти до 240 БРПЛ «Трайдент-2» (D-5), установленных на 12 ПЛАРБ типа «Колумбия» с большим водоизмещением по сравнению с ПЛАРБ типа «Огайо» (соответственно, 21 тыс. тонн против около 19 тыс. тонн). Впоследствии названные БРПЛ будут заменены на новые типы. Первая атомная субмарина нового класса должна выйти на боевое патрулирование в 2031 году.

Третьей составляющей обновлённой триады станут 60 тяжёлых бомбардировщиков типа «B-21 Рейдер» («B-3») с ядерными крылатыми ракетами воздушного базирования и корректируемыми ядерными авиабомбами. Первый такой бомбардировщик должен быть сооружён в 2025 году. Впоследствии на этих бомбардировщиках будет размещена новая крылатая ракета повышенной дальности с ядерным боезарядом. Кроме того, триаду усилит неназванное количество бомбардировщиков средней дальности двойного назначения, то есть способных нести авиабомбы в ядерном или неядерном снаряжении. Основу последних составят уже поступающие в ВВС США новые многофункциональные истребители-бомбардировщики «F-35» передового наземного и авианосного базирования, что означает, что они появятся на аэродромах многих государств Североатлантического альянса (НАТО) и его внеблоковых союзников, прилегающих к территории России и КНР.

17 февраля 2018 года на Мюнхенской конференции по безопасности первый заместитель госсекретаря США Джон Салливан заявил:

«Мы не собираемся представлять новые виды вооружений, мы собираемся реализовывать договор о стратегических наступательных вооружениях (СНВ). Мы планируем — как Китай и Россия — модернизировать нашу ядерную триаду. В противном случае у нас будут системы, которые устарели на десятки лет, у которых давно вышел срок годности. Если у нас не будет надёжного сдерживания, то в такой ситуации угроза возникновения ядерной войны будет куда больше, чем в той ситуации, когда у нас есть модернизированные системы, когда мы поддерживаем установленные соглашениями уровни [боезарядов]»

См. также
 Тактическое ядерное оружие
 Ядерный арсенал Российской Федерации
 Ядерный арсенал США
 Ядерный арсенал Китая
 Ядерный арсенал Франции
 Ядерное вооружение Индии

Примечания

Ссылки
 Андрей Шушков, Михаил Цурков. Ядерная триада США: перспективы развития. — Приоритет отдаётся авиационному компоненту. Журнал «Воздушно-космическая оборона» (ВКО) // vko.ru (11 октября 2013 года)
 Вадим Пономарёв. Ядерная триада: Россия стала неуязвимой. — Россия произвела успешный запуск баллистической ракеты «Булава». Интернет-ресурс «Эксперт Online» // expert.ru (10 сентября 2014 года)
 Олег Божов. Ядерные планы России: как обновляются самые мощные войска. — Триада, которая нас спасает. Газета «Московский комсомолец» // mk.ru (26 августа 2015 года)
 Дмитрий Киселёв, ведущий. Видео: Учения ядерной триады России стали антивоенным посланием США. — 30 октября 2015 года прошли одновременные учения так называемой ядерной триады России — наших стратегических сил, задействовать которые предполагается в самом крайнем случае. Телеканал «Россия-1», программа «Вести недели», эфир от 1 ноября 2015 года. // russia.tv
 Александр Ермаков, независимый военный эксперт. Стратегические ядерные силы России и США. Сегодня и завтра. Журнал «Новый оборонный заказ. Стратегии» // dfnc.ru (13 сентября 2016 года)

Ядерная стратегия

redpajama_set_name: RedPajamaWikipedia


Congratulations you have just won £100,000,000!
1 Response to Congratulations you have just won £100,000,000!
Submitted… Hope I will win big this time!
Have tried this before, but somehow the Lottery went bankrupt even though my entry fee was paid on time!


With the decree 11861 of 11/02/2004, the number of lebanese muhafazah-s increased from six to eight. Two muhafazah-s were created, Baalbek-Hermel and Aakkar.
First level : Eight muhafazah-s.
Second level : Twenty-five kaza-s.
Third level : 1 029 municipalities (baladia, may 2016). Two or more municipalities could form a federation of municipalities.
Read more : Decree about Lebanon administrative divisions n°116 of 12/06/1959 (in arabic).


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Two female women medical doctors looking at x-rays in a hospital.
Two female women medical doctors looking at x-rays in a hospital
Radiology Adobe Stock licensed
Artificial Intelligence, Medicine and Health
AI Can Help Spot Cancers—But It's No Magic Wand
When I spoke last month about how AI can help with cancer diagnoses, I failed to appreciate some of the complexities of medical diagnosis
Last month, I suggested that Deep Learning-based AI could be useful in radiology. Radiologists evaluate many images daily, often for small anomalies indicative of disease or cancer. Our eyes and mind get tired, increasing the chance something is missed. An AI system tweaked to favor false positives over false negatives could help reduce the workload and raise the odds of finding conditions early.
I still believe that. But I failed to appreciate all that goes into a radiologist's role. I was making the mistake that many AI boosters (whom I've criticized) make: When we reduce a problem to something a computer can process we can all too easily leave out the crux of the problem.
Sai Balasubramanian (right), who has both legal and medical training, knows much more than I do about radiology. While he sees a place for AI-assisted diagnosis, interpreting images involves much more than pattern matching:
While AI systems may be able to detect routine medical problems based on pre-defined criteria, there is significant value provided by a trained radiologist that software simply cannot replace. This includes the clinical correlation of images with the physical state of the patient, qualitative assessments of past images with current images to determine progression of disease, and ultimately the most human aspect of medicine, working with other healthcare teams to make collaborative care decisions.
Sai Balasubramanian, "Artificial Intelligence Is Not Ready For The Intricacies Of Radiology" at Forbes
Radiology images come from a patient with a family history and other possible conditions. Further, as he points out, any one image is a snapshot in time, a brief part of the whole story. And it's the whole story that matters, not a single image, perhaps taken out of context.
Balasubramanian goes on to note other challenges with deploying AI in radiology, including finding a way to obtaining the data necessary to train the systems without violating privacy. Further, the training data must include a sufficient swath of the global population to eliminate a frequent source of bias, the inadvertent use of samples that mostly include members of one group.
Still, even with these qualifications, Balasubramanian does see AI as augmenting a physician's workflow, "especially given increasing radiology demands in clinical medicine."
And that's key word: Augmenting. AI systems can be useful tools, like every other tool we build, to assist us.
Even then, we must not dumb down the problems to the point that the solution no longer matters as long as we can say we have found one. Like driving, hiring, and so much else that we do, medical diagnosis is not an On-Off, True-False affair. Medical diagnosis entails judgment, some only the conscious human mind can do.
How AI can help us fight cancer: Breast cancer is an excellent example of how AI can speed up early detection. (Brendan Dixon)
Why was IBM Watson a flop in medicine? Robert J. Marks and Gary S. Smith discuss how the AI couldn't identify which information in the tsunami of medical literature actually mattered.
Can AI combat misleading medical research? No, because AI doesn't address the "Texas Sharpshooter Fallacies" that produce the bad data.
Fellow, Walter Bradley Center for Natural & Artificial Intelligence
Brendan Dixon is a Software Architect with experience designing, creating, and managing projects of all sizes. His first foray into Artificial Intelligence was in the 1980s when he built an Expert System to assist in the diagnosis of software problems at IBM. Since then, he's worked both as a Principal Engineer and Development Manager for industry leaders, such as Microsoft and Amazon, and numerous start-ups. While he spent most of that time other types of software, he's remained engaged and interested in Artificial Intelligence.
Follow Brendan
Researchers: Trees "sense" their height and weight
Trees rarely just fall over but we seldom stop to think about why they don't. Recently, University of Helsinki researchers discovered that trees can "sense" their weight in relation to their height and adjust their growth for stability. Manipulating the weight of downy birch trees, the …
The Expanse, Season 4: The Best So Far?
We've all heard this at some point: Whether it's The Lord of the Rings, Ender's Game, or Hunger Games, we are told, "That was a great movie but the books were better." I'm not ashamed to admit that I rarely read the books beforehand. I can certainly see why people prefer them. …

redpajama_set_name: RedPajamaCommonCrawl


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Best sunshine holidays for larger families (3 or more kids)
Home + Europe
Last updated 23rd November 2017
Planning a family holiday is an exciting time. For larger families however, it can be tricky to find resorts that cater to the needs of your brood. But don't despair. Here are nine brilliant overseas package holidays for families with three or more children to take the strain out of booking a break away.
1/9 7 nights self-catering for 6 people, Ibiza, £2,487
A few minutes' stroll from one of Portinatx's beaches, the Apartmentos Del Ray is a peaceful resort bordered by palm trees. Enjoy a dip in the pool while the kids play in the children's pool or relax with a drink on the sun terrace. When you fancy a day out take a ride on a glass-bottomed boat, browse the hippie market at Portinatx or laze about on the postcard-perfect S'Arenal Gros beach. The home-from-home apartments sleep up to six people and and come with a kitchenette, satellite television and terrace or balcony.
What: Return flights from Gatwick plus transfers and seven nights' self-catering accommodation in a two-bedroom apartment for six people
Where: Ibiza, Spain
When: 10-17 August 2018
Find out more and book this holiday at Thomson
2/9 7 nights' all-inclusive in Costa Dorada, for 5 people, £2,192
This family-friendly hotel benefits from an ideal location in quiet Cap Salou, within walking distance of local shops and restaurants. A free shuttle bus takes guests to nearby Salou beach with its plentiful family fun- choose from banana boats, jet skis or daily boat trips. Festival Village offers a full entertainment programme including arts and crafts, team games and chilled movie nights as well as a popular mini disco! The kids' club provides a supervised play area and dedicated entertainers for little ones, while adults can get involved with water polo, pool competitions and evening quizzes.
One-bedroom apartments at the Festival Village feature two double beds plus a cot, and two-bedroom apartments sleep up to six people, with double and sofa beds as well as an extra bathroom. All the apartments have a spacious living area and kitchenette as well as satellite television and a private balcony or terrace.
What: Return airport transfers and flights from London Gatwick plus seven nights' all-inclusive accommodation in a one-bedroom apartment with two double beds plus cot
Where: Festival Village, Costa Dorada, Spain
When: 2-9 August 2018
Find out more and book this holiday at Thomas Cook
3/9 7 nights' self-catering for 6 people at theme park, Holland, £1,177
What more could you want on a family holiday than a child-friendly campsite and theme park in one? Duinrell holiday and amusement park in Holland is home to over 40 rides including bumper boats, a family rollercoaster, a loop-the-loop coaster and a Ferris wheel. Other attractions include mini golf, a miniature railway and outdoor trampolines. When you're tired out why not take a seat and watch one of the musical shows or peruse the shopping court for souvenirs? Duinrell also has a tropical swimming paradise known as the Tiki Pool, with 16 waterslides, a kids' waterpark with waterfall and a lazy river.
Guests can refuel at one of the resort's restaurants, grab a takeaway or pick up some local sweets and baked goods from the on-site shops. Stay in a modern Esprit holiday home with two bedrooms, sofa beds, air conditioning and a fully equipped kitchen.
What: Seven nights' self-catering accommodation for up to six people in a two-bedroom Esprit holiday home
Where: Duinrell holiday park, Wassenaar, Holland
Find out more and book this holiday at Eurocamp
4/9 7 self-catering for 6 people, Majorca, £2,184
Treat yourself with a summer break at this holiday village on the sunny Spanish island of Majorca. The 17 buildings are dotted with swimming pools, playgrounds and sport facilities, making it the perfect place to keep kids busy throughout your stay. A children's club will keep little ones entertained from morning 'til night and the resort offers children's menus and highchairs in all its restaurants. The BelleVue is just 300m from local shops, bars and restaurants and 800m from the nearby beach. The apartments feature a kitchen and dining area, breakfast bar and a furnished terrace or balcony.
What: Return flights and transfers from London Stansted plus seven nights' self-catering accommodation in a two-bedroom apartment
Where: BelleVue Club Majorca, Spain
Find out more and book at Jet2holidays
5/9 7 nights 'all-inclusive plus' for 5 people, Spain, £4,240
You won't need to step outside your resort on a break to Magic Natura, which has its very own animal-themed water-park. Stay in a premium two-bed Polynesian-themed lodge with thatched roof and flat-screen television, fridge and daily maid service. Stepping out of your lodge you'll have unlimited access to the Terra Natura animal park, with over 1500 animals and a 'zoo-immersion' concept that allows guests to get up close with the animals. There is also a children's club for ages 4-16 with games, toys and organised activities. When it comes to dining, choose from three restaurants including two with kids' buffets; your 'all-inclusive plus' concept also means unlimited ice cream, snacks and drinks around the resort including in the waterpark. A complimentary shuttle bus will ferry your family to the local sandy beach for even more fun in the sun!
What: Return flights from London Stansted; transfers plus seven nights' 'all-inclusive plus' accommodation for five people in a two-bedroom Polynesian-themed lodge
Where: Magic Natura Animal Waterpark & Polynesian Lodge Resort, Benidorm, Costa Blanca
6/9 7 nights' self-catering for 5 people, Spain, £2,424
These bright and breezy apartments with ocean views are ideally situated a few minutes' walk from Calpe's Levante beach. Families can enjoy light interiors and kitchenettes in-room as well as two swimming pools and a separate children's pool. Guests are also free to use the facilities at the sister hotel, the AR Roca Esmeralda Hotel & Spa less than five minutes' walk away. A buffet restaurant offers international cuisine and there is also the Grill plus a cafe and bar to enjoy. Explore the local area with a trip to see flamingos at Les Salines National Park, wander through the Old Quarter or hike up the Penon d'Ifach rock.
What: Return flights from London Gatwick, transfers plus seven nights' self-catering accommodation in a two-bedroom apartment
Where: Esmeralda Suites, Costa Blanca, Spain
When: 7-14 August 2018
7/9 7 nights for 5 people, Crete, £2,435
Enjoy relaxing by the pool in this child-friendly beach apartment complex in Stalis, Crete. The two-bedroom family apartments are just 50 metres from the beach and the shops and local restaurants serving authentic Cretan and international food. The complex itself has a popular buffet restaurant and two bars as well spacious gardens, mini-golf and a swimming pool with a slide for outdoor family fun! The two-bedroom apartments are simply furnished and include a flat-screen television, iron and kitchenette. Take in all that the local area has to offer with watersports on Stalis beach, trips into the mountains and visits to rural traditional villages.
What: Return flights from Stansted, transfers and seven nights' self-catering accommodation in a two-bedroom apartment
Where: Amazones Villas, Stalis, Crete
When: 27 July-3 August 2018
8/9 7 nights' in a self-catering apartment for 6 people, Turkey, £2,568
A Tripadvisor favourite, the Club Evin hotel is just 700 metres from the beach and the lively main resort of Marmaris. The hotel pool area has a waterslide for kids (and fun-loving grown-ups!) and guests are entertained with shows and quizzes each evening. An outstanding restaurant serves children's favourites as well as authentic Turkish cuisine and there are plenty more local eateries nearby. The rooms are clean and bright and feature a kitchenette with balcony or terrace. Families can enjoy day trips on boats to nearby coves and explore the marine life and crystal-clear water of the Mediterranean coast.
What: Return flights from Gatwick plus return transfers and seven nights' self-catering in a two-bedroom apartment
Where: Club Evin, Marmaris, Turkey
9/9 7 nights' self-catering for 6 people, Portugal, £2,587
A 15 minute walk from the pretty Portuguese fishing town of Alvor, the Club Alvorferias apartments in the Algarve have a lot to offer large families. Make a splash in the two swimming pools, enjoy a leisurely lunch in the a la carte restaurant or let the kids enjoy their day at the children's club while you walk down to the ocean. The hotel provides a complimentary shuttle bus down to the beach so you won't have to worry about little ones' tired legs! The two-bedroom apartments have spacious bedrooms, a kitchenette and family dining area.
What: Return flights from Luton airport, transfers plus seven nights' self-catering accommodation in a two-bedroom apartment
Where: Club Alvorferias apartments, Algarve, Portugal
Why 2023 is a great year for big family adventure holidays
Great deals on family breaks to Corsica, Sardinia, Gambia and Cape Verde
Freewheeling in France: how to cycle La Vélomaritime with kids
Naturhotel Forsthofgut: a little Aspen in Austria that's perfect for families


So the furnace went out (again). We might be the last people you want to talk to, but in a situation like this, R & M Climate Control Service Experts Heating & Air Conditioning in Knoxville should be your very first call. It doesn't matter if it's early in the morning or late at night – our NATE-certified technicians on call 24/7/365. We'll be there before you know it and get the job done fast – so you can get back to your routine and not have to worry about needing another furnace repair anytime soon.
Whether your unit is electric, gas, duel fuel, heat pump, oil or a boiler. We have everything needed to get the job done correctly the first time. Think of the repair process as though our technician were skilled doctor, working tirelessly to diagnose and provide the best prescription for your home's comfort problem.
If you can noticeably smell gas, call R & M Climate Control Service Experts right away.
Find out more about our repair services for electric and gas furnaces or oil furnaces and boilers on our website. Need one of our experts in Knoxville for a furnace repair service ASAP? Call 865-229-6176 to get it set up, and we'll get your furnace working smoothly before you know it.


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BySponsored Content
After checking out GreenYrLife, an addictive new Facebook app that combines entertainment with education about living a green lifestyle, we at Earth911 wanted to know more — after all, we're all about environmental education with a dose of entertainment as well. So we caught up with Catherine Tait, chair and co-founder of iThentic.com, the digital content company behind GreenYrLife, to talk about what makes this game different than any you've played before.
Earth911: For those who haven't seen it yet, what is GreenYrLife?
Catherine Tait: It's a Facebook game that we developed to capture the enthusiasm of the FarmVille experience but to direct the idea of a game where people are able to be rewarded not only for virtual actions but real-life actions related to the daily greening of their lives. We wanted to create a Facebook game that would look and feel different; we added some fun smaller micro-games but also a video series to engage viewers and players and go deeper into the subject matter.
All the information we're trying to provide is really handy, digestible pieces of information. Our approach was to take the scariness out of climate change and take the tedium out of making good environmental choices and try to translate that into something fun and easy that will have a benefit.
E911: How long did it take to create the app?
CT: From start to finish, almost three years. Canada Media Fund dedicates a portion of its financing to innovative digital applications, so we went through that process and were awarded funding. We also wanted to put in place a partner such as the David Suzuki Foundation, which we donate a portion of our proceeds to. Also, our videos were carefully researched and have a lot of different moving parts, so that all took time.
E911: What are the topics of the video series you've added into the game?
CT: First, "GreenTips" includes very short tips on actions you can take to green your life.
"The Dirt on Green" is more investigative in approach. Each episode starts with a question that comes from the community and touches on choices that people might be making, such as cloth diapers vs. store-bought diapers. It's hosted by Scientific American journalist Christie Nicholson.
The final series, "Today on Earth," was produced with David Suzuki's daughter Sarika Cullis-Suzuki, a marine biologist and scientist in her own right. It's a factual-based series of information on environmental issues.
E911: There are lots of games and apps and things to do online these days. What makes GreenYrLife stand out?
CT: What we tried to do is make this game, which has a social issue at its core, as entertaining as possible. We hope people in the environmental community will be our first core users and then it will be played in high schools and other educational environments. At its core, it is a Facebook game with some of the similar experiences as others, but the difference is in the video and multiple points of entry to be engaged.
E911: Why was this project something iThentic wanted to take on?
CT: Our company is probably best known for narrative-based scripted series, and we're storytellers at heart. This is more of an educational, factual-based digital product, but we felt if we could bring our storytelling skills to the challenge, we could advance the conversation on reversing climate change.
We care about the environment as a group of people. We asked ourselves, "How can we make this subject that's often terrifying and vast and makes people feel helpless more digestible and accessible?" The scope of the game is more far-reaching than similar games you might find online today.
For more about GreenYrLife, check out our article that breaks down the game's features.
Solar Power Conspiracy?


Here's the complete uncut version of one of the great masterpieces of world literature presented by famed Royal Shakespeare Company director Peter Brook. This is the complete 5hrs and 12mins T.V. miniseries that spawns over 2 dvds.
One of the great masterpieces of world literature comes to vivid life in an elaborate production from acclaimed theater and film innovator Peter Brook (Marat/Sade, Lord of the Flies). This collection of ancient Sanskrit stories (composed into the longest book ever written) comprises a series of enlightened fables at the heart of countless beliefs, legends, and teachings; indeed, its very title means "the great story of mankind." Brook and award-winning writer Jean-Claude Carriere worked for eight years to develop this epic concerning two sides of a royal family, the Pandavas and the Kauravas, whose struggle leads to a fascinating voyage of emotions, contradictions, and dreams, filled with subplots which are alternately comic and tragic but always gloriously entertaining.
The dvds are encoded Region 0(playable on dvd players worldwide). The audio and video quality is EXCELLENT. There also, is an interactive menus with scene selection for easy navigation through the dvds, and bonus material.


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Kenneth "Ken" Lovsin, född 4 december 1966 i Peace River i Alberta, är en kanadensisk före detta ishockeyspelare.
Lovsin blev olympisk silvermedaljör i ishockey vid vinterspelen 1994 i Lillehammer.

Källor

Kanadensiska ishockeyspelare
Kanadensiska olympiska silvermedaljörer
Tävlande vid olympiska vinterspelen 1994 från Kanada
Tävlande i ishockey vid olympiska vinterspelen 1994
Olympiska silvermedaljörer 1994
Idrottare från Alberta
Födda 1966
Levande personer
Män


Performers John Morris, vocals, piano, organ, and bass ; Pam Morris, vocals ; with Butch Johnson, bass ; Donald Brown, guitar ; and Ronnie Jerry, Tony Lewis, drums.
Contents Side 1. I feel a shout (4:04) -- I've got Jesus (3:22) -- I love that man (4:22) -- Just one drop (5:53) -- Things could be worst (3:53) -- Side 2. I'm getting stronger (5:42) -- Let's cross this bridge together (4:45) -- Keep me saved (4:52) -- Praise the Lord (5:30).
Recording Notes Recorded live at Bethany Apostolic Church (Los Angeles, Calif.) by recording engineer, Donald Brown.
Note Program notes by Evangelist John Morris, and biographical notes by Elder Bruce Scott Riley. ; All songs written and composed by Evangelist John Morris. ; Photography by Arthur Lewis.


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Gaudy Welsh tea pot
This Gaudy Welsh tea pot was made in the 19th century in Staffordshire. Gaudy Welsh ware is characterised by the patterns of stylised flowers, highlighted with splashes of lustre glaze. The colours are usually dark blue, rusty red, yellow and green. The patterns are thought to have started as naïve imitations of Japanese Imari ware porcelain which had the same colour with gold highlights. Imari ware was produced in Arita especially for export to Europe and was very popular from the mid 1600s to the early 1700s. It was an expensive luxury item and began to be copied in China and Europe.
The majority of Gaudy Welsh ware was made in Staffordshire, England between 1820 and 1860 and was very popular in Wales. A small proportion of Gaudy Welsh ware was made in the Cambrian Pottery, Swansea and in the South Wales Pottery in Llanelli from about 1840.
The pattern on this Staffordshire teapot is known as the tulip pattern and it is part of a tea service. Several homes in Wales had Welsh Gaudy ceramics. They were often transferred from one generation to another such as with these from Cwrt y Llyn, Pentrefoelas that were in the possession of the family since the mid 19th century.
Salesmen travelled from Staffordshire to Welsh markets to sell earthenware pieces at prices most people could afford. In the watercolour Market Day in Bangor, painted in about 1856 by Joseph Josiah Dodd and now in Storiel's collection, you can see a china stall selling domestic crockery.
Lustre ware, with its metallic shiny glazes, was also popular in Wales and the two types of affordable crockery were proudly displayed on wooden dressers, catching the flickering firelight. This china could have been used to eat and drink from, but the glazes, especially the metallic ones, wear off quickly. By the 19th century tea had become the most common drink in Britain.


Chaffee Tire provides Computerized Wheel Balancing services to Salida, CO, Poncha Springs, CO, Buena Vista, CO, and other surrounding areas.
Why Should You Have Computerized Wheel Balancing Services Performed at Chaffee Tire?
We proudly service the Computerized Wheel Balancing needs of customers in Salida, CO, Poncha Springs, CO, Buena Vista, CO, and surrounding areas.


$60k of your hard-earned revenue may be going home in the pockets of thieves. The NRA estimates that, on average, Net Income ('NI') for most restaurant companies is around 5% to 6%. The NRA also states that loss due to fraud at the restaurant runs around 4% of sales CASH is KING. Assuming the NRA estimates for theft are accurate then it would be safe to further assume that a restaurant with $1,500,000 ('$1.5M') in sales could conservatively lose $45K or possibly even $60K in revenue due to theft.
Given the number of ways theft can occur, it's no wonder the percentage (4%) remains as high as it does. It's not my intent to attempt to try and cover each way a restaurant can be losing money, rather, I'll focus on the most popular -cash theft.
OK, by now you're probably thinking there's no way we're losing that much and maybe you're not, but ask yourself this; is it possible that $20 or $40 or even $60 a day goes missing? Maybe? Well, let's look at how that adds up because little numbers have a way of compounding and becoming much larger than one might expect.
For example, if theft in your locations is running just $20 a day then it's possible that you're losing roughly $7,300 annually from each location where this is occurring - at $40 it becomes $14,600 and at $60 it becomes $21,600.
Lastly, multiply the amount you feel is possible your business could be losing times the number of your locations for the total impact. E.G., $40 Daily X 30 Days X 35 Locations = $42,000 Monthly. No matter how you slice it, it's a lot of money, money that should be getting back to your bottom line but isn't.
My next question – does your current approach to cash theft help you detect a loss of $20 - $60 a day? If you're open 16 hours a day that's just $1.25 an hour - again, doesn't seem like something anyone should be concerned about, right. But that's exactly what the people who are committing this type of theft count on.
The best way to combat this level of fraud is by using the data your point-of-sale system makes available (check level detail) and then combine it with an exception-based reporting technique to determine who, among your staff (cashiers, servers, managers) are most likely stealing.
Check Level Detail or as some call it; Transaction Level Detail (TLD) is basically every line item rung up on every check in every one of your restaurants every day. Exception-based reporting is a process created by establishing thresholds, generally percentages of what's acceptable / unacceptable to your company, that are then applied to your TLD to produce exceptions.
Examines all the data provided for each restaurant.
Automatically delivers exceptions via 'alerts' -further improves efficiency, convenience and speed to resolution – Alerts can be sent as email or SMS text messages – keeping managers informed without having to login.
While it's not realistic to think you can prevent all theft in every location, it is realistic to think you can minimize this activity by actively monitoring check level detail. For example, you can start by monitoring discounts, voids, overrings, and any other means your POS system allows money to be removed from a check. Next, set a threshold for what's acceptable. Your company may determine that it's unacceptable to have more than 10% of every dollar discounted, voided, etc., from any check. Therefore, once this threshold is applied to the TLD, a list of individuals who exceed this level will be produced. This limits your review to just those individuals who's behavior matches or exceeds the threshold. Of course you may be thinking 10% is too high and that 0% is the only percentage that's acceptable and while I don't disagree that's a noble goal, I'd argue, setting your thresholds at very low levels to begin will cause a significant percentage of your employees to be flagged making it very difficult, if not impossible, for your team to sort out who the real culprits are.
So, in the beginning, my suggestion would be to set your threshold slightly higher than you may be comfortable with and then keep an eye your reporting and make sure the threshold is doing a reasonable job and adjust as necessary. Over time, you'll want to lower it – again keeping an eye to make sure you're not flagging everyone. The goal here is to slowly tighten up the level of acceptability and further minimize theft. Your check level detail is a powerful tool and when combined with exception-based reporting it's made even more powerful in helping you combat the many ways cash theft can occur and contribute to that $20 - $60 loss.
The steps we've described cover some of what you need to be aware of and a few ways to track individuals that may be stealing cash directly. Once you have your exception list in hand, the individuals identified need to be confronted and a resolution for next steps needs to be identified. That can include something as simple as more training is needed or more drastic; termination required. In most, if not all, of these situations having an ability to track the time to resolution and the resolution itself can be equally helpful. There are solutions available that can help you automate these steps.
Having a well-rounded approach that helps you see how quickly each incident is being addressed along with its outcome can help you / your team ensure issues are being addressed in a timely manner and as we stated at the beginning; time is money. Having the ability to quickly locate and remove individuals that are stealing can have a significant impact on your bottom line.
What could you do with and extra $60K?


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	arg.apikey = ak;

	http.get({
		url: vtApiEndpoint + method + '?' + qs.stringify(arg),
		headers: {
			'user-agent': userAgent
		}
	}, function(err, res) {
		if (err) {
			callback(err);
			return;
		}

		jsonHandler(res.buffer, callback);
	});
};

/**
 * Issues a POST request to the VirtusTotal API
 *
 * @private
 */
var postRequest = function(method, arg, callback) {
	if (!ak) {
		throw new Error('The VirusTotal API requires an API key.');
	}

	arg.apikey = ak;

	http.post({
		url: vtApiEndpoint + method,
		reqBody: new Buffer(qs.stringify(arg)),
		headers: {
			'user-agent': userAgent,
			'content-type': 'application/x-www-form-urlencoded;charset=utf-8'
		}
	}, function(err, res) {
		if (err) {
			callback(err);
			return;
		}

		jsonHandler(res.buffer, callback);
	});
};

/**
 * Wraps a POST request with multipart/form-data. Only used by scanFile
 *
 * @private
 */
var postRequestMultipart = function(resource, callback) {
	if (!ak) {
		throw new Error('The VirusTotal API requires an API key.');
	}

	var form = new http.FormData();
	form.append('apikey', ak);

	if (typeof resource === 'string') {
		form.append('file', fs.createReadStream(resource));
	}

	if (typeof resource === 'object') {
		var haveFile = false;
		if (resource.stream instanceof ReadStream) {
			form.append('file', resource.stream);
			haveFile = true;
		}

		if (resource.stream instanceof IncomingMessage) {
			var meta = {};

			if (resource.filename) {
				meta.filename = resource.filename;
			}

			if (resource.size) {
				meta.knownLength = resource.size;
			} else if (resource.stream.headers['content-length']) {
				meta.knownLength = resource.stream.headers['content-length'];
			}

			form.append('file', resource.stream, meta);
			haveFile = true;
		}

		if (!haveFile) {
			form.append('file', resource.stream, {
				filename: resource.filename,
				knownLength: resource.size
			});
		}
	}

	http.post({
		url: vtApiEndpoint + 'file/scan',
		reqBody: form,
		headers: {
			'user-agent': userAgent
		}
	}, function(err, res) {
		if (err) {
			callback(err);
			return;
		}

		jsonHandler(res.buffer, callback);
	});
};

/**
 * Checks the method arguments
 *
 * @private
 */
var checkArgs = function(resource, callback, method) {
	if (!resource) {
		throw new Error('You need to define a resource argument in order to use ' + method + '().');
	}

	if (!callback || typeof callback !== 'function') {
		throw new Error('You need to define a callback for ' + method + '().');
	}
};

// Public API

/**
 * Sets the VirusTotal API key
 *
 * @param {String} apiKey VirusTotal API key
 *
 * @example
// it is mandatory to call this before any other remote calls to the VirusTotal API
virustotal.setKey('your-virustotal-api-key');
 */
exports.setKey = function(apiKey) {
	ak = String(apiKey);
};

// VirusTotal API methods

// https://www.virustotal.com/vtapi/v2/file/scan
/**
 * Send and scan a file
 *
 * @param {Mixed} resource - a String for a disk path or a {@link module:virustotal~streamWrapper}
 * @param {module:virustotal~callback} callback Completion callback
 *
 * @throws {Mixed} You need to define a resource argument in order to use scanFile().
 * @throws {module:virustotal~callback} You need to define a callback for scanFile().
 *
 * @example
// scan a file stored to disk
virustotal.scanFile('/path/to/file', function (err, res) {
	if (err) {
		console.error(err);
		return;
	}

	console.log(res);
});

// wrapping a ReadStream created with fs.createReadStream
virustotal.scanFile({
	stream: fs.createReadStream('/path/to/file')
}, function (err, res) {
	if (err) {
		console.error(err);
		return;
	}

	console.log(res);
});

// wrapping an IncomingMessage (a HTTP response)
http.get('http://example.org/file.exe', function (im) {
	virustotal.scanFile({
		stream: im,
		// you may specify a filename
		// the form-data library may detect it from the IncomingMessage
		// but this could produce the wrong filename
		// your call
		filename: 'file.exe'
	}, function (err, res) {
		if (err) {
			console.error(err);
			return;
		}

		console.log(res);
	});
});

// wrapping a generic stream
// in this case you need to specify both the filename and the size of the stream
virustotal.scanFile({
	stream: readableStream,
	filename: 'filename.exe',
	size: 1337
}, function (err, res) {
	if (err) {
		console.error(err);
		return;
	}

	console.log(res);
});
 */
exports.scanFile = function(resource, callback) {
	checkArgs(resource, callback, 'scanFile');
	postRequestMultipart(resource, callback);
};

// https://www.virustotal.com/vtapi/v2/file/rescan
/**
 * Rescan already submitted files
 *
 * @param {module:virustotal~virustotalResource} resource A VirusTotal resource. The CSV list may have up to 25 items
 * @param {module:virustotal~callback} callback Completion callback
 *
 * @throws {module:virustotal~virustotalResource} You need to define a resource argument in order to use rescanFile().
 * @throws {module:virustotal~callback} You need to define a callback for rescanFile().
 *
 * @example
virustotal.rescanFile(
	'2fc19a61b81055c199f23de35b7eb8b2827e283442965bc1898c0e044563d836',
	function (err, res) {
		if (err) {
			console.error(err);
			return;
		}

		console.log(res);
	}
);
 */
exports.rescanFile = function(resource, callback) {
	checkArgs(resource, callback, 'rescanFile');
	postRequest('file/rescan', {
		resource: resource
	}, callback);
};

// https://www.virustotal.com/vtapi/v2/file/report
/**
 * Retrieve a file scan report
 *
 * @param {module:virustotal~virustotalResource} resource A VirusTotal resource. The CSV list may have up to 4 items
 * @param {module:virustotal~callback} callback Completion callback
 *
 * @throws {module:virustotal~virustotalResource} You need to define a resource argument in order to use getFileReport().
 * @throws {module:virustotal~callback} You need to define a callback for getFileReport().
 *
 * @example
virustotal.getFileReport(
	'2fc19a61b81055c199f23de35b7eb8b2827e283442965bc1898c0e044563d836',
	function (err, res) {
		if (err) {
			console.error(err);
			return;
		}

		console.log(res);
	}
);
 */
exports.getFileReport = function(resource, callback) {
	checkArgs(resource, callback, 'getFileReport');
	postRequest('file/report', {
		resource: resource
	}, callback);
};

// https://www.virustotal.com/vtapi/v2/url/scan
/**
 * Submit and scan a URL
 *
 * @param {String} resource An URL or a CSV list of up to 4 URLs
 * @param {module:virustotal~callback} callback Completion callback
 *
 * @throws {String} You need to define a resource argument in order to use scanUrl().
 * @throws {module:virustotal~callback} You need to define a callback for scanUrl().
 *
 * @example
virustotal.scanUrl('http://example.org/', function (err, res) {
	if (err) {
		console.error(err);
		return;
	}

	console.log(res);
});
 */
exports.scanUrl = function(resource, callback) {
	checkArgs(resource, callback, 'scanUrl');
	postRequest('url/scan', {
		url: resource
	}, callback);
};

// http://www.virustotal.com/vtapi/v2/url/report
/**
 * Retrieve an URL scan report
 *
 * @param {String} resource An URL, a scan_id returned by {@link module:virustotal.scanUrl}, or a CSV list made of URLs and scan_ids. The CSV list may have up to 4 items
 * @param {Boolean} scan Optional; Set this to true to scan the URL if no report is found for it in VirusTotal's database
 * @param {module:virustotal~callback} callback Completion callback
 *
 * @throws {String} You need to define a resource argument in order to use getUrlReport().
 * @throws {module:virustotal~callback} You need to define a callback for getUrlReport().
 *
 * @example
virustotal.getUrlReport('http://example.org/', function (err, res) {
	if (err) {
		console.error(err);
		return;
	}

	console.log(res);
});
 */
exports.getUrlReport = function(resource, scan, callback) {
	if (!callback && typeof scan === 'function') {
		callback = scan;
		scan = null;
	}

	checkArgs(resource, callback, 'getUrlReport');

	var arg = {
		resource: resource
	};
	if (scan) {
		arg.scan = 1;
	}

	postRequest('url/report', arg, callback);
};

// http://www.virustotal.com/vtapi/v2/ip-address/report
/**
 * Retrieve IP address report
 *
 * @param {String} resource An IPv4 address
 * @param {module:virustotal~callback} callback Completion callback
 *
 * @throws {String} You need to define a resource argument in order to use getIpReport().
 * @throws {module:virustotal~callback} You need to define a callback for getIpReport().
 *
 * @example
virustotal.getIpReport('8.8.8.8', function (err, res) {
	if (err) {
		console.error(err);
		return;
	}

	console.log(res);
});
 */
exports.getIpReport = function(resource, callback) {
	checkArgs(resource, callback, 'getIpReport');
	getRequest('ip-address/report', {
		ip: resource
	}, callback);
};

// http://www.virustotal.com/vtapi/v2/domain/report
/**
 * Retrieve a domain report
 *
 * @param {String} resource Domain name
 * @param {module:virustotal~callback} callback Completion callback
 *
 * @throws {String} You need to define a resource argument in order to use getDomainReport().
 * @throws {module:virustotal~callback} You need to define a callback for getDomainReport().
 *
 * @example
virustotal.getDomainReport('example.org', function (err, res) {
	if (err) {
		console.error(err);
		return;
	}

	console.log(res);
});
 */
exports.getDomainReport = function(resource, callback) {
	checkArgs(resource, callback, 'getDomainReport');
	getRequest('domain/report', {
		domain: resource
	}, callback);
};

// https://www.virustotal.com/vtapi/v2/comments/put
/**
 * Creates a new comment for file/URL
 *
 * @param {String} resource A {@link module:virustotal~virustotalResource} or URL submitted via {@link module:virustotal.scanUrl}
 * @param {String} comment The comment
 * @param {Array} tags Optional; List of tags to prepend to the comment
 * @param {module:virustotal~callback} callback Completion callback
 *
 * @throws {String} You need to define a resource argument in order to use makeComment().
 * @throws {module:virustotal~callback} You need to define a callback for makeComment().
 *
 * @example
virustotal.makeComment(
	'2fc19a61b81055c199f23de35b7eb8b2827e283442965bc1898c0e044563d836',
	'Yahoo! Messenger installer.',
	['goodware', 'clean'],
	function (err, res) {
		if (err) {
			console.error(err);
			return;
		}

		console.log(res);
	}
);
 */
exports.makeComment = function(resource, comment, tags, callback) {
	if (!callback && typeof tags === 'function') {
		callback = tags;
		tags = null;
	}

	checkArgs(resource, callback, 'makeComment');

	if (!comment) {
		throw new Error('You need to define a comment argument in order to use makeComment().');
	}

	if (tags instanceof Array) {
		var i, tag;
		for (i in tags) {
			if (tags.hasOwnProperty(i)) {
				tag = tags[i];
				if (tag.charAt(0) !== '#') {
					tag = '#' + tag;
				}
				tags[i] = tag;
			}
		}
		comment = comment + ' ' + tags.join(' ');
	}

	postRequest('comments/put', {
		resource: resource,
		comment: comment
	}, callback);
};

// Documentation section

/**
 * The completion callback
 *
 * @callback module:virustotal~callback
 * @param {module:virustotal~error} error The passed error or *null* on success
 * @param {module:virustotal~result} result The VirusTotal report or confirmation for succesful action
 */

/**
 * The result Object which is obtained by parsing the JSON response of the VirusTotal API. The result is passed to the success case only when its response_code equals to 1
 *
 * @typedef module:virustotal~result
 * @type {Object}
 */

/**
 * The Error instance describing what went wrong. There are three types of errors. 1. A HTTP error which may happen under the conditions described by the [Response basics](https://www.virustotal.com/en/documentation/public-api/#response-basics), handled by the http-request library's [stdError object](http://saltwaterc.github.io/http-request/module-request.html#stdError). 2. If the JSON is corrupt, then the error is defined by the exception thrown by [JSON.parse](http://es5.github.io/#x15.12). 3. The last case of error is when the response_code property of the returned JSON does not equal to 1
 *
 * @typedef module:virustotal~error
 * @type {Error}
 * @property {Object} json Defined when the parsed JSON has the response_code property different than 1. Contains the response from the VirusTotal API describing what went wrong. error.json.verbose_msg describes the error in detail
 */

/**
 * md5/sha1/sha256 file hash, a scan_id (sha256-timestamp as returned by {@link module:virustotal.scanFile}), or a CSV list made of a combination of hashes and scan_ids
 *
 * @typedef module:virustotal~virustotalResource
 * @type {String}
 */

/**
 * The stream wrapper for uploading a file to the VirusTotal API by using {@link module:virustotal.scanFile}
 *
 * @typedef module:virustotal~streamWrapper
 * @type {Object}
 * @property {Object} stream Mandatory; The Readable Stream instance
 * @property {String} filename Optional; The file name of the resource. This property recommended for streams that are a [http.IncommingMessage](http://nodejs.org/api/http.html#http_http_incomingmessage), and mandatory for generic Readable Streams
 * @property {Number} size Optional; The size of the stream. It is mandatory to define this property for streams with unknown length. This includes a http.IncomingMessage that uses chunked transfer which does not pass a content-length header. The content-lenght header value is used only when the size property is undefined. Compressed responses with gzip or deflate provide a wrong value for the size property, therefore it is recommended to avoid using HTTP compression if you wish to use the content-length value
 */

redpajama_set_name: RedPajamaGithub


text:
Isherwood, Christopher, 1904-1986
Existence: 1904-08-26 - 1986-01-04
Christopher Isherwood (1904-1986), Anglo-American novelist, playwright, screenwriter, autobiographer, and diarist.
Decision Magazine papers
Call Number: MS 176
Overview: Correspondence, drafts of articles and poems, legal documents, press releases, clippings and other papers of the magazine which was published in New York from January 1941 to February 1942 under the editorship of Klaus Mann. Correspondents and writers include W.H. Auden, André Gide, Sir Julian Huxley, Christopher Isherwood, Heinrich Mann, Thomas Mann, William Carlos Williams and Stefan Zweig. Also in the papers is the proof for an unpublished article by Vladimir Nabokov, "Soviet Literature...
Found in: Manuscripts and Archives > Decision Magazine papers
New World Writing records
Call Number: YCAL MSS 388
Overview: The collection documents all aspects of the production and promotion of the literary magazine New World Writing from its first issue in 1952 to its last issue in 1959. Correspondence, including letters by and about various authors whose work was published in the magazine, and manuscripts, including corrected typescripts of published works, shed light on the selection and editorial process. Highlights include the corrected typescript of "Catch-18" by Joseph Heller, originally published in issue...
Found in: Beinecke Rare Book and Manuscript Library > New World Writing records
More about 'Isherwood, Christopher, 1904-1986'
Bradshaw-Isherwood, Christopher William, 1904-1986
אישרווד, כריסטופר
Subject: Periodicals X


text:
Tuesday May 27 , 2014 12:00 AM
"I thank God for the help you gave me." (Philippians 1:5a NCV)
Developing an attitude of gratitude does not come naturally. We are not by nature grateful people. We are by nature discontented. We always want more or something different.
In the book of Philippians, Paul was writing to the church that he started in Philippi, where a woman named Lydia opened up her home and, along with others, welcomed Paul to the city. The Philippian church even helped fund Paul's missionary journeys. In Philippians 1:5, Paul says, "I thank God for the help you gave me" (NCV).
The thing is, Paul didn't have a good time in Philippi. In fact, it was one of his roughest churches to get started. When Paul went to this city to start a church, he was beaten, whipped, humiliated, falsely arrested, thrown into prison, and survived an earthquake. Then, he was politely asked by the city leaders to leave town.
Yet Paul told the believers, "Every time I think of you, I give thanks to my God" (Philippians 1:3 NLT).
What is Paul doing there? He is choosing selective memory. Philippi was not a happy place for Paul, and he endured a lot of persecution and suffering during his time in that city. But he chose not to dwell on painful memories and instead expressed his gratitude for the good things that had been done for him and through him.
The longer you know someone, the more likely you are to take that person for granted and to look for faults and remember the bad things instead of the good things.
Are you still living some painful memories with some people in your life? You've never let them off the hook, and you can't enjoy the relationship because you're still holding on to the past.
You need to understand that memories are a choice. I heard a story one time about two friends who were talking. One of them asked the other, "Don't you remember that time when your husband did this?" Her friend replied, "I distinctly remember forgetting that."
Your memories are a choice. If you want to hold on to your painful memories, go right ahead. But you're not going to be happy! Paul had a lot of reasons to have painful memories of Philippi. Instead, he made the choice to be grateful for the people in his life and the work God was doing in and through them. When you do the same, God will bless your relationships far beyond your expectations.
Why is it sometimes easier to hold on to painful memories than replace them with good ones?
How does focusing on good memories change your expectations for the future?


We tailor our programs to meet the needs of your specific organization. Our Linen conservation initiatives revolve around proper-utilization-per-linen-item relative to your census and/or patient days.
Once we determine your optimum inventory and distribution, we provide comprehensive guidance on inventories and proper product application directly to your end users. These usage initiatives are designed to ensure that all areas have sufficient amounts of linen items while reducing any hoarding and misuse of merchandise in your system, leading to an efficient and cost effective linen program.
Our team will also make recommendations to denote where linen items may be interchangeable to provide the level of service required at the lowest possible cost. Our experience has proven there are many alternatives in bed make-up and distribution procedures that will help monitor and control overall linen utilization.
Our goal is to always provide proper amounts of each linen item to all areas of your facility and to manage this process to ensure the needs of your staff are met while staying within the financial requirements of your organization.


UV-A is in the wavelength range of 315-400nm and is mostly transmitted through the atmosphere before hitting on earth. UV-A was not an important key to photosynthesis for scientists for a long time. Recent studies have shown that UV-A radiation's positive effects on the growth and flowering of plants. This means that rays outside the PAR spectrum are impacting the fundamental photosynthesis processes.
When we use the term UV-Light, we often associate it with UV-B. UV-B is in the wavelength range between 290-315nm and is usually filtered by the ozone layer (where it is sufficiently thick). UV-Light generally causes problems, whether for us humans or for plants. Too much UV-B light can inhibit plant growth and destroy important nucleic acids. PAR light and UV-A drive the production of chloroplasts (including beta-carotene) to strengthen the defense system against stress and diseases, and provide some protection against UV-B rays. However, permanent exposure to UV-B should be avoided in any case until the last 2 weeks of flowering.
Certain plant species may benefit from UV-B. During the flowering phase, the production of potent flowers can be accelerated. Due to the cell damage by UV-B the plant attempts to protect exposed cells by increased resin production.
Figure 2: UV light (especially UV-C light) can cause irreversible damage to plant DNA. Plants can prevent damage from UV light by making physical and chemical "sunscreens".
Figure 4: Stink bugs are a particularly annoying predator of soybean plants. Not only do they eat the leaves, but they let out a stinky smell if you touch them!
Figure 5: Powdery mildew can reduce cannabis yields by attacking leaves. Fortunately, UV-B light is an effective method for preventing the spread of spores.
In 1983, the University of Maryland conducted a study to measure the changes in THC levels (and CBD) of Sativa plants grown indoors under HPS vs. identical plants indoors under HPS, but supplemented with 4 different levels of UVB light supplied by mercury vapor based UVB lamps. The UVB levels ranged from Zero (0) UVB on the low end, to Equatorial Sun levels UVB on the high end, and a couple increments between.
The results were quite remarkable. The baseline Sativa plants with no UVB measured 25% THC. The plants at Equatorial sun level UVB measured 33% THC. That's over a 30% increase in THC levels by just supplementing UVB light throughout the growth cycle (CBD levels did not change).
This study was what prompted California LightWorks to be the first and only LED grow-light company to integrate mercury-vapor UVB lamps in their SolarStorm LED grow-light line with great success. Do not let competitors fool you with claims of "UV" in their products supplied by LEDs. UV LED's are EXTREMELY expensive and inefficient, and completely impractical for use in grow-lights. The UV our competitors refer to is UVA, NOT UVB, and it is provided in ANY LED fixture that uses the Deep Blue LEDs because the very low end of the Deep Blue spectrum band overlaps slightly into the very top of what is considered the UVA range. This has allowed them to rather disingenuously claim their fixtures supply "UV". But understand, it is only UVA, and only in miniscule amounts that will have absolutely NO measurable effect on THC levels. Mercury vapor is the only legitimate system for UVB supplementation available today, and it is only found in the California LightWorks product line.
For all these reasons, the potential benefits from Photomorphogenesis may be greater in Cannabis than virtually any other cash crop, and as more data is coming in on this fascinating topic all the time, it is clear there are far more benefits to flowering with LEDs than just energy savings.
Back in the early years of the medical cannabis industry, some savvy individual made the connection that the strongest marijuana historically has come from the lowest equatorial latitudes and the highest altitudes. It was speculated that possibly it was the higher levels of UVB found in the tropics or at high elevations that might influence THC production. One popular theory reasoned that the THC effectively served as a sunscreen to protect the sensitive seeds from UVB damage, much like melanin protects human skin. Growers have realized an increase of up to 30% THC percentage by using supplemental UVB light but the actual mechanism was not well understood.
Finally, researchers appear to have identified the actual pathway of exactly how UVB affects THC production. While the analysis is somewhat technical, we'll do our best to outline the results below. Ready?
The Ultraviolet (UV) spectrum ranges from about 100 nanometers (nm) and 400 nm. UVA, from about 315 nm to 400 nm, is an extension of the deep blue light spectrum and is included in most artificial light sources. Some level of photosynthesis occurs in this range. UVB, from about 280 to 315, is somewhat damaging to plants in high levels and causes sunburns on humans. UVC, from about 100 nm to 280 nm is highly damaging to all living things. This is often used in sterilization and killing bacteria.
UVB causes damage in plants in much the same way as it damages human skin, and plants created defenses against UVB in the form of a protein called UVR8.
UVR8 is a protein molecule which senses UV, and then "tells" plant cells to change their behavior. Exactly how UVR8 molecules sense UV was recently discovered and is pretty interesting. UVR8 is what chemists call a "dimer," which simply means that it's made of two structurally similar protein subunits. When UV light hits the two protein subunits in UVR8, their charge weakens and they break apart. To help visualize this, imagine rubbing two balloons against one another. The balloons will stick together because of a static charge. Now imagine the balloons get rained on. The water takes the static charge with it and the two balloons fly apart. In this example, the balloons are the two protein subunits and the rain is UV light cascading down on the plant cell. After the protein subunits break apart, they head to the cell nucleus to deliver their information.
One of these changes caused by this reaction is very important in your cannabis garden. UV stress stimulates cannabis' production of chemicals via the phenylpropanoid pathway, specifically malonyl-CoA and phenylalanine. Why is this important? Because cannabis uses malonyl-CoA to make Olivtol, which it in turn uses to make THC. So finally the specific pathway which increases Cannabis potency when exposed to UV light is understood, and we can use this information to our advantage.
UVB light is already generated by the mercury found in all HID (i.e. HPS and Metal Halide) light sources, but it's typically blocked by the bulb's outer glass jacket. Ordinary glass blocks over 90% of UVB radiation, so UVB levels will naturally be a little higher using open fixtures with no glass lens.
Many growers have been aware of the benefits of UVB and have used supplemental lighting to boost potency. However, be aware, there is a threshold where the damage to yield caused by high level UVB will exceed any benefits in potency, so caution and careful design protocols MUST be used when attempting to supplement UVB. It is also VERY important to be EXTREMELY careful using off-the-shelf UVB sources like lizard lights that are not specifically designed for human exposure, because while sunlight has quite high levels of UVB, the intensity of the sun prevents people from staring straight at it. UVB is invisible, so your eyes can't tell you if they are getting too much UVB from a UVB light source in your grow room, and your eyes and skin can be damaged if the levels are too high. So it's worth repeating: Extreme caution must be observed when using secondary UVB supplementation.


Author Rado, Jeffrey, 1970- author.
Title Living with schizophrenia : a family guide to making a difference / Jeffrey Rado, MD, and Philip G. Janicak, MD.
Publication Info. Baltimore : Johns Hopkins University Press, 2016.
4 copies being processed for GDL Central Library Non-Fiction.
Description ix, 128 pages ; 23 cm.
Bibliography Includes bibliographical references (pages 115-120) and index.
Contents What is schizophrenia? -- What causes schizophrenia? -- Biological therapies for schizophrenia -- Psychosocial and behavioral treatments for schizophrenia -- Staying well -- Schizophrenia and the family -- Medical conditions and schizophrenia -- Looking to the future.
Subject Schizophrenia -- Popular works.
Schizophrenia -- Treatment -- Popular works.
Added Author Janicak, Philip G, author.


Ever since I started RF online, I have always wanted to get weapons and armors without having to buy from other co-players. Well, as I went on with the game I found out the answer to that was Crafting. My first character was an item crafter but I had a hard time finding a good source for crafting recipes. So, to those who need one, below is a compilation of item combinations for RF online. For those newbies out there, Item combination allows you to create items out of ingredients both looted from monsters or through mining of ores.
But first things first. You must know where to have ingredients combined. There is an NPC in the game called "Hero". This NPC allows you to combine materials. When you find him, try and talk to him and click on the Item Combination option. You will be prompted to a window that has five (5) empty boxes. This is where you place crafting ingredients. These can be looted from different monsters in the game.
Hope this Online Crafting Guide helps.


text:
Q: If $(X_n+Y_n)$ has bounded variance, is the same true for $(X_n)$ and $(Y_n)$? Let $(X_n)$ and $(Y_n)$ be two sequences of random variables defined on the same probability space such that the variance of all components $X_n$, $Y_n$ is finite and the sequence of variances of $X_n+Y_n$ is non-zero and bounded. Does this imply that the variance sequences of $X_n$ and $Y_n$ are bounded as well?
In formulas, let $a_n^2$ and $b_n^2$ be the variance of $X_n$ and $Y_n$, respectively, and let $c_n$ be the covariance of $X_n$ and $Y_n$. Then the assumption from above translates into
$$0 < \operatorname{Var}  (X_n+Y_n) = a_n^2 + b_n^2 + 2c_n \leq M$$
for some $M \geq 0$. From a purely analytical point of view, one could take $a_n^2=b_n^2=n+M/2$ and $c_n=-n$. Then $(X_n)$ and $(Y_n)$ would have unbounded variances but the variance of $(X_n+Y_n)$ would be bounded. Do random variables of this form exist?

A: They do. Simply choose, say, $X_n$ a Bernoulli random variable taking values $n$ or $-n$ with probability $\frac 12$ for each. Notice that $Var(X_n) = n^2$. Define $Y_n = - X_n$. You have $Var(X_n + Y_n) = 0$ and, to answer your last interrogation, $Cov(X_n,Y_n) = - Var(X_n) = -n^2$.
Edit : Let now $Z$ be some random variable, as nice as you like (say, another symmetric Bernoulli, but on $\{-1,1\}$ this time) and independant from all the $X_n$. Choose $Y_n = - X_n + Z$. Then $Var(X_n + Y_n) \equiv 1$ and $Var(X_n) \sim Var(Y_n) \sim n^2$.

redpajama_set_name: RedPajamaStackExchange


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Here are some of the Books that i found were available in the amazon.com .
The Number of Books / resources are plenty for starting with the Windows Phone 7 .
Some of the books are available for pre order too .
With so many interests among the Book authors and the publishers , looks like there is more for the developers to choose the right one to start the development .
Don't forget there is MSDN too so start with .


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' Copyright (c) Microsoft.  All Rights Reserved.  Licensed under the Apache License, Version 2.0.  See License.txt in the project root for license information.

Imports System.Threading
Imports System.Threading.Tasks
Imports Microsoft.CodeAnalysis.Completion
Imports Microsoft.CodeAnalysis.Options
Imports Microsoft.CodeAnalysis.Text
Imports Roslyn.Utilities

Namespace Microsoft.CodeAnalysis.Editor.UnitTests.IntelliSense

    Friend Class MockCompletionProvider
        Inherits CommonCompletionProvider

        Private ReadOnly _getItems As Func(Of Document, Integer, CancellationToken, IEnumerable(Of CompletionItem))
        Private ReadOnly _isTriggerCharacter As Func(Of SourceText, Integer, Boolean)

        Public Sub New(Optional getItems As Func(Of Document, Integer, CancellationToken, IEnumerable(Of CompletionItem)) = Nothing,
                       Optional isTriggerCharacter As Func(Of SourceText, Integer, Boolean) = Nothing)
            Me._getItems = getItems
            Me._isTriggerCharacter = isTriggerCharacter
        End Sub

        Public Overrides Function ProvideCompletionsAsync(context As CompletionContext) As Task
            If _getItems Is Nothing Then
                Return SpecializedTasks.EmptyTask
            End If

            Dim items = _getItems(context.Document, context.Position, context.CancellationToken)

            If items Is Nothing Then
                Return SpecializedTasks.EmptyTask
            End If

            For Each item In items
                context.AddItem(item)
            Next

            Return SpecializedTasks.EmptyTask
        End Function

        Friend Overrides Function IsInsertionTrigger(text As SourceText, characterPosition As Integer, options As OptionSet) As Boolean
            Return If(_isTriggerCharacter Is Nothing, Nothing, _isTriggerCharacter(text, characterPosition))
        End Function

    End Class
End Namespace


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Develop To some type of recycling pro through the addition of a dedicated centre for recycling into your own kitchen renovations. It turns into a fantastic method of eliminating those bins and totes which clutter your kitchen flooring.
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Grinding Teeth of Duck-bill Dinosaurs More Advanced Than Horses' main content.
A new scientific study shows that duck-billed dinosaurs pulverized tough and abrasive plants with grinding teeth more complex than those of cows, horses, and other well-known modern grazers. The researchers, which included Mark Norell, the chair of the Museum's Division of Paleontology, are the first to recover material properties from fossilized teeth.
Duck-bill dinosaurs, also known as hadrosaurids, were the dominant plant-eaters in what are now Europe, North America, and Asia during the Late Cretaceous about 85 million years ago. With broad jaws bearing as many as 1,400 teeth, hadrosaurids were previously thought to have chewing surfaces similar to other reptiles, which have teeth comprised of just two tissues—enamel, a hard hypermineralized material, and orthodentine, a soft bonelike tissue.
But paleontologists who study the fossilized teeth of these animals in detail have long suspected that they were not that simple.
To investigate the dinosaurs' dental structure and properties in depth, Norell worked with lead author Gregory Erickson, a biology professor at Florida State University, and a team of engineers on a series of novel experiments. Erickson sectioned the fossilized teeth and made microscope slides from them. These revealed that hadrosaurids actually had six different types of dental tissues—four more than reptiles and two more than expert mammal grinders like horses, cows, and elephants. Using a technique called nanoindentation, in which a diamond-tipped probe is indented and/or drawn across the fossilized teeth to mimic the grinding of abrasive food, the researchers also determined the differential hardness and wear rates of the dental tissues.
In addition to the four dental tissues found in mammals—enamel, orthodentine, secondary dentine that helps prevent cavities, and coronal cementum that supports the teeth's crests—the hadrosaurid teeth include giant tubules and a thick mantle dentine. These extra tissues are thought to provide additional prevention against abscesses. Also unlike mammalian teeth, the dental tissue distribution in hadrosaurids greatly varied in each tooth. Together, these characteristics suggest that hadrosaurids evolved the most advanced grinding capacity known in vertebrate animals, which might have led to their extensive diversification.
The paper (abstract here) was published this week in the journal Science.


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DCLM Daily Manna For Today | 14 March 2022 | Devotional
Home/Devotional/DCLM Daily Manna Devotional/DCLM Daily Manna For Today | 14 March 2022 | Devotional
DCLM Daily Manna 14th March 2022 Deeper Life Devotional For Monday Written by Pastor W. F. Kumuyi — Tragedy Of Arrogance
TOPIC: Tragedy Of Arrogance
TEXT: Isaiah 9:8-21 (KJV)
8 The Lord sent a word into Jacob, and it hath lighted upon Israel.
9 And all the people shall know, even Ephraim and the inhabitant of Samaria, that say in the pride and stoutness of heart,
10 The bricks are fallen down, but we will build with hewn stones: the sycomores are cut down, but we will change them into cedars.
11 Therefore the Lord shall set up the adversaries of Rezin against him, and join his enemies together;
12 The Syrians before, and the Philistines behind; and they shall devour Israel with open mouth. For all this his anger is not turned away, but his hand is stretched out still.
13 For the people turneth not unto him that smiteth them, they neither seek the Lord of hosts.
14 Therefore the Lord will cut off from Israel head and tail, branch and rush, in one day
15 The ancient and honourable, he is the head; and the prophet that teacheth lies, he is the tail.
16 For the leaders of this people cause them to err; and those led by them are destroyed.
17 Therefore the Lord shall have no joy in their young men, neither shall have mercy on their fatherless and widows: for every one is an hypocrite and an evildoer, and every mouth speaketh folly. For all this his anger is not turned away, but his hand is stretched out still.
18 For wickedness burneth as the fire: it shall devour the briers and thorns, and shall kindle in the thickets of the forest, and they shall mount up like the lifting up of smoke.
19 Through the wrath of the Lord of hosts is the land darkened, and the people shall be as the fuel of the fire: no man shall spare his brother
20 And he shall snatch on the right hand, and be hungry; and he shall eat on the left hand, and they shall not be satisfied: they shall eat every man the flesh of his own arm:
21 Manasseh, Ephraim; and Ephraim, Manasseh: and they together shall be against Judah. For all this his anger is not turned away, but his hand is stretched out still.
KEY VERSE: "The bricks are fallen down, but we will build with hewn stones: the sycomores are cut down, but we will change them into cedars." – (Isaiah 9:10)
DCLM DAILY MANNA FOR TODAY
The sin of arrogance and pride s tragic with fatal consequences. It brought down Lucifer and some other angels. Pride also destroyed Korah and his gang, as well as Ahithophel. It is the height of transgression because it attempts to place those ensnared by it on the same pedestal with God. Thus, the proud seek to play the Creator of heaven and earth.
ALSO, READ DCLM Daily Manna For Today | 2 March 2022 | Devotional
The same was the case with the nation of Israel. The land had become prosperous, with the leaders and their people feeling self-sufficient. They believed this material satisfaction positioned them independent of God. In a theocratic society like Israel, this was a dangerous national outlook. It was arrogance that plunged the whole society into sin. This, needless to say, brought swift judgment on the land and its leaders.
But as it has been with the sin of pride, the people's response to God's chastisement was dismal. It pushed them into more acts of rebellion. They felt they did not need God and could stand on their own.
When the Lord chastened them, they said: "The bricks are fallen down, but we will build with hewn stones: the sycomores are cut down, but we will change them into cedars." The Bible says they acted "in the pride and stoutness of heart".
God has great love for His children; thus, He continues to warn the haughty who shun the "quiet and meek spirit" that should characterise them. It is a broad path that leads to perdition. When punishment comes from God to whip us into line, we must accept it thankfully as the gentle rebuke of a caring Father.
ALSO, READ DCLM Daily Manna For Today | 28 February 2022 | Devotional
THOUGHT FOR THE DAY:
Only negligent parents ignore their erring children.
THE BIBLE IN ONE YEAR:
DCLM Daily Manna 14 March 2022 was written by Pastor W. F. Kumuyi; is the founder and General Superintendent of the Deeper Life Bible Church situated at KM 42 on the busy Lagos-Ibadan Expressway, Nigeria.
ALSO, READ DCLM Daily Manna 20 July 2021 Devotional
ALSO, ARE YOU BORN AGAIN? IF NO ACCEPT JESUS NOW
DCLM Daily Manna Today


JavaParaTrooper Answered on March 15, 2017.
If you don't want to use Bootcamp, you could try to use Parallels on your Mac, which enables you to run both operating systems simultaneously.
I haven't tried it for AutoCAD which I expect will be a lot of memory and processor intensive but for other programs it works wonderfully well.
They have a 14 day free trial here: http://trial.parallels.com/?lang=en&terr=us so I suggest you test it with AutoCAD before you buy it.
Good luck, I'd be interested to here how it goes!
CadMan Answered on March 16, 2017.
I read on the Autodesk forums that there are no plans to release Civil3D for Mac, so if you really want to run it on your Macintosh it looks like you're going to have to go either Bootcamp or Parallels which will allow you to run PC programs.
Here's a short article on the Pros and Cons of Bootcamp vs Parallels to help you see the difference.
KingCAD Answered on March 17, 2017.
Good find KingCAD… and with some other options too that I didn't think of!
There is another option for the OP. He doesn't need to use Parallels or Bootcamp, he could create a virtual machine in Citrix or VMWare as the article KingCAD posted says.
Personally I've used every method. I like Parallels because it let's you run Mac and PC applications at the same time (with Bootcamp you literally need to choose Windows or Mac OS on startup). Citrix and VMWare will allow you to create a virtual machine on your Mac, but in my experience they are a hassle to setup.
So, depending of whether you need access to your Mac applications at the same time as Civil 3D (choose Parallels) or not (choose Bootcamp).
Lakers Answered on March 17, 2017.
I'd agree with you Lakers. If ps_c3d goes for Citrix of VMWare he'd have the hassle of finding a Windows image to install. The Parallels or Bootcamp option seem far more simple to me!
amitshah316 Answered on March 19, 2017.
Super User Answered on March 19, 2017.


text:
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E info@petans.co.uk
BSTW
STCW Maritime >
LocationNorwich
Start time8:30 AM
Price (exc. VAT)£975.00
Validity 5 Years
Accreditation MCA
5 Day STCW Basic Safety Training Week
If you are employed or engaged in any capacity onboard a ship you will be required to successfully complete those elements of MCA-approved basic training appropriate to your duties and functions.
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Recommended refresher training
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