A guide to "the feel good record of the summer"
"The feel good record of the summer? That was the plan…"
"Surprisingly, we were able to accomplish this in Santorini, Greece, at a studio called Black Rock, thus the album's title. As opposed to working in Malibu or London, it was a terrific spot to really focus on the music. Cellphones, computers… We were cut off from a lot of typical distractions. After a few days, I didn't even know what was going on in the world. I found it very easy to channel my energies on record making.
"Greece is so beautiful and inspiring. The sunsets are spectacular, the street sounds are lively, the people are friendly and genuine - the whole vibe was very conducive to feeling reckless and having fun.
"I got my usual gang together - the amazing producer Kevin Shirley, Carmine Rojas on bass, Rick Melick on keyboards, and Anton Fig and Bogie Bowles on drums and percussion - but I was very happy to welcome some local Greek folk musicians who added different flavours with instruments like the bouzouki and clarino.
"Bobby Parker's a soul and R&B artist from the late '50s and early '60s. I don't want to sound like a name-dropper, but I found out about him from Robert Plant, who suggested I do this song. He thought it would suit my voice and the sound of the band.
"What's interesting is that Steal Your Heart Away was almost on Led Zeppelin's first album. How's that for some cool rock trivia? Apparently, the band cut a version of it, but for some reason it didn't make the album. I don't know why.
"When I recorded it, I changed the key around and made it sort of punk-rock blues, kind of like what Paul Weller used to do with The Jam. I think it's a fun song to kick off the album.
"John Hiatt's written so many great songs, but this one really spoke to me. He doesn't so much write songs as he paints pictures with words and melodies. I liked the lyrical content, the groove, and I thought that I could do a little English-style Cream thing with it.
"It was a challenge to sing, though, 'cause it's really high. Basically, I had to find a new place in my voice and feel comfortable with it. It worked out pretty well, so I guess my vocal lessons are paying off.
"That's right, I take vocal lessons - done it for years. There's nothing wrong with it. Hey, are you gonna tell a Major League baseball player he shouldn't have a pitching coach? Whatever gets your game on, you know?"
"Greece was a muse. It inspired creativity in magical ways that I can't even begin to understand or explain. All I know is, I walked around with my antenna up, and before you knew it I was writing songs at a pretty brisk pace.
"Santorini has these really great sunsets that are very different from anywhere else I've ever seen. They're like these giant fireballs that burn up the sky and then disappear into the ocean. The title, When The Fire Hits The Sea, came to me one day when I was marveling at this incredible sight.
"Another original. No, I wasn't thinking of The Beatles - I know John Lennon's first group was called The Quarrymen - but rather, I was inspired by my environment. I wanted to do sort of a world music treatment of something akin to The Thrill Is Gone.
"So even though it's a bit laid back, it's still blues. It's got a different kind of melody and texture to it. It's a very dramatic worldly track - that's about the best way I can describe it.
"This track was left over from the Sloe Gin album. It didn't fit that record, but when we listened to it with fresh ears in Greece it felt like it would really work on Black Rock.
"We had cut the basics in 2007 and they sounded cool, so there was no reason to mess with them. But I redid my vocal 'cause I thought I was singing better than a couple of years ago. Also, I put a new solo on it. Suddenly, there it was - boom!
"People ask me if it's daunting to cover a well-known song or a classic, and the answer is no. Would I cover Stairway To Heaven? Of course not; there's nothing I could add to it.
"This was me being somewhat ambitious, but in the end, I think it's one of the strongest tracks on the record.
"It pushed me vocally, that's for sure. It's bluesy but it's almost like a hymn. Playing-wise, too, it transported me. I probably played guitar with more restraint than usual, although I do a solo that kind of builds and builds.
"Three Times A Fool is straight-up blues in the best possible sense. Give me a song like this and I get excited; I wanna dig in. I was thinking about cutting this one for a while, but I could never sing it properly - until now.
"The key's in a high A, and that's a scary place - it's kind of in your head voice, you know? It's not falsetto, but it's up there. I never could tap into my head voice, not fully, but now I can.
"I was on a roll. Eric Clapton played with me at the Royal Albert Hall last year (for Further On Up The Road), so I said to myself, 'What the hell? Let me see if my luck will continue.' I called up Mr King - that's what I call him, even though he's a dear friend - and I said, 'Um, would you possibly consider playing on my new record?' To my surprise, he said yes.
"We were thinking of two songs, Buzz Me and Night Life, both of which are on BB's album Blues Is King (1967) but I chose Night Life because I think it's more iconic.
"BB cut his parts in Vegas. The guy works more than I do; he can't just jump on a plane to Greece. He nailed his takes and was incredible. Then it was up to me to see how I could compete with him.
"It's my five-part blues. I always wanted to write a song in which nothing was repeated, so I painstakingly put this one together.
"It was pretty hard. To write something that's a song, that's cohesive and flows, that's melodic and tells a story and isn't just a bunch of disconnected sections… Not so easy.
"This is me having my Freddie King moment. A few people covered this song, but to me, Freddie King's version was the classic, and I knew I could have a lot of fun with it.
"When I hear this song, I picture mod girls in London in 1967 wearing go-go boots and dancing on those black-and-white TV shows; or guys in funky clothes gettin' down - you know, like Freddie King. It's just a blast. You're in a bad mood? Put this song on, it'll cheer you up."
"Even though I wrote it in Greece, I was very inspired by Ry Cooder's Cherry Ball Blues, which, believe me, can take you a lot of places, but Greece is not one of them.
"With the title in my head, I went off and wrote down the lyrics. Took me about a hour. That's probably long for writing lyrics. I'm always of the mind that they should come in one short burst.
"Yes, it's one of my own compositions, but I still don't like it very much. In fact, it's my least-favorite track. Oddly enough, it's the most-requested song from the album so far. Every time we've played it live, people go nuts.
"What's the lesson here? That I never would have made it as an A&R guy. When it comes down to choosing what the public wants, I'm clueless. Good thing I never tried out for Clive Davis' job!
"I don't mean to go off, but I just think it's generic. But the band loved it and Kevin thought it was great, so I was like, 'Fine, we'll put it on the album, but that doesn't mean I'm gonna like it.'"
Have a cocktail for this album closer - Joe did!
"It's a sweet little Blind Boy Fuller song. If it sounds a little loose, well, there's a very good reason for that. We recorded it during our album-wrap celebration, and everybody was in various states of intoxication.
"We had this massive barbecue on the back porch of the studio, with all these drinks and about 20 bottles of wine. Before you knew what was going on, guitars started coming out and we were playing. Get alcohol and musicians together and that's what happens.
"Anton, I think he was he was scratching his drumsticks on a wicker chair; Rick, our keyboardist, was banging on something while he was whistling; and I was singing and playing lead guitar. Meanwhile, Kevin directed the whole thing.
"Given the circumstances under which we recorded it, it's a little ramshackle, but it's got spirit. A neat capper for the album. Listen to it and go back to the beginning again - that's what I say."
Come back next week when Joe talks MusicRadar through his favourite bluesmen ever.


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Home finance homework help Erikson eriksons psychosocial human development theory essay
Erikson eriksons psychosocial human development theory essay
Erikson's Psychosocial Theory of Development: Young Adults The young adult has numerous stresses placed upon them through the route of development. Erikson has theorised developmental stages of growth into tasks.
Moral Development and Importance of Moral Reasoning - Introduction: Lawrence Kohlberg was the follower of Piaget's theory of Moral development in principle but wanted to make his own theory by expanding his theory and study on that particular topic. Eriksons stages of psychosocial development, as articulated by Erik Erikson, is a psychoanalytic theory which identifies eight earrings judith viorst pdf stages through which a healthily developing human. Moral Development and Importance of Moral Reasoning - Introduction: Lawrence Kohlberg was the follower of Piaget's theory of Moral development in principle but wanted to make his own theory by expanding his theory and study on that particular topic.
Contact Us Freud and Erikson? Among early developmental theories, the most influential and controversial theory of development was proposed by Sigmund Freud. Freud proposed psychosexual stages of development, which changed the entire view on the childs development Storr, Erickson followed the footsteps of Freud but disagreed with his psychosexual stages to some extent and proposed his psychosocial stages of development.
Although there are lots of similarities as Erickson theory of development is heavily influenced by Freuds work, but it is also very different in its own unique way Bee, This essay is focused on similarities and differences between these two theories and also research for and against each theory.
Freud proposed that child development happens in fixed stages, which he named as psychosexual stages of development. He introduced the concept of libido, which is concentrated on different erogenous zones during different stages of development.
Freud believed that if psychosexual stages are completed successfully, a healthy personality is developed, but if a conflict is not resolved at any stage, a fixation can occur, which means that individual will be stuck at that stage until the conflict is resolved.
Erickson also believed that development takes place in the form of predetermined stages, but instead of five, he proposed eight stages. He suggested that development of healthy personality is formed by mastering the inner and outer dangers and if a certain capacity is not formed at its schedule, it can have unfavourable consequences on the development.
According to Freud and Erickson, the first stage starts from birth and lasts approximately up to a year. Freud called this an oral stage and the libido is concentrated on the mouth area. The infant drives the pleasure from the mouth by sucking, feeding and biting.
Freud believed an over oral stimulation leads to oral receptive personality which results in over dependent and self-centred individual.
Critically evaluate Eriksons psychosocial theory Essay Example | Graduateway
Whereas, under oral stimulation could lead to an oral aggressive personality i. Erickson on the other hand, called this stage as Trust vs. Mistrust and suggests that during this stage; child is dependent on the caregiver for his needs and the quality of care defines the personality of the person.
This stage is comparable to Freud Oral stage as Ericson believed that failure to develop trust between infant and caregiver will result in mistrust in the self and the world, which is similar to oral aggressive personality traits.
But too much protectiveness can lead to over-dependence and gullibility which are also the traits of oral receptive personality. The balance is required to achieve a healthy personality by both Freud and Erickson Gay, The second stage in psychosexual stages is an anal stage, which starts at around 1 year up to 3 years.
Freud suggested that libido is centred at the anus and child draws pleasure from controlling bowel movements. Fixation at this stage can either lead to anal retentive personality, which means a stringy, extraordinary orderly, rigid and obsessive personality or anal expulsive, which is a very messy, disorganised and rebellious personality.
According to psychosocial stages, this stage is called autonomy versus doubt, child develop some self-sufficiency during this stage and like Freud, Ericson also believed that potty training plays an important role during this age but refused the idea that this stage can only be defined by potty training.
Erickson suggests that self esteem is build at this stage through gaining control over major muscular development; holding bowels is required for a childs self esteem.
According to Freud, the third stage of development, phallic stage is very important in a childs development. This stage begins at the age of 3 until 5 and the focus of libido is at genitals in both sexes.
The pleasure is gained through masturbation.Scope and content note. This series contains various documents related to Erik Erikson, including. a prospectus describing a six-part film series documenting Erik and Joan Erikson's lives and work; and the first page of an undated biography of Erikson.
believe that Freud misjudged some important dimensions of human development. Throughout this essay, Erikson's psychosocial model will be explored, discussed and evaluated interms of it's concepts, theories and assumptions.
The. theoretical underpinning will be discussed with reference to the nature versus nurture. Psychosocial Stages Essay. Psychosocial Stages in Relation to Lia Erik Erikson, a developmental psychologist and psychoanalyst known for his theory on psychosocial developmental on human beings, proposed a lifespan model of development taking in five stages up to the age of eighteen and three further stages beyond into adulthood.
Erikson suggests that establishing a sense of safety and trust is a crucial developmental task, and that failure to do so has long-term developmental implications. Erikson believed that children develop through a number of stages. Developmental psychologist Erik H. Erikson () was best known for his theory on social development of human beings, and for coining the phrase identity crisis..
The theory describes eight stages through which a healthily developing human should pass from infancy to late adulthood. Erik Erikson was a German-born American from - Erik Erikson Stages of Personality Development Essay introduction. Erik was known for his psychosocial theory of emotional development of human beings.
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Erikson?s psychosocial development theory Research Paper Help – A Research Paper

redpajama_set_name: RedPajamaCommonCrawl


Cancer lies between Gemini to the west and Leo to the east, Lynx to the north and Canis Minor and Hydra to the south. Its name is Latin for 'crab' and it is commonly represented as such. Cancer is relatively small among the constellations with an area of only 505 square degrees and its stars are rather faint. Cancer is the dimmest of the zodiacal constellations, having only two stars above the fourth magnitude. Of special note in the cancer constellation is 55 Cnc which has a quintuple planet system with one super-earth and four gas giants, one of which is in the habitable zone and as of such has expected temperatures similar to Earth.
Those personalities born between June 21st and July 22nd are in the fourth sign of the zodiac. This cardinal, water sign is endowed with sensitivity to the vibrations of their surroundings and the thoughts and feelings of those around them. This same element of sensitivity can lead to shyness and even withdrawal and moodiness when feelings are impacted. Exhibiting calm strength, they are usually well liked by their peers. Although they are emotional, those born under this sign are able to conceal emotions very effectively. This ability, combined with a polished but tough outer shell, can make them a difficult opponent. Being that this sign is the ruler of the 4th zodiac house, which oversees the home and family, it's likely that they enjoy creating a safe and comfortable base for loved ones to be shielded from the outside world. Cancer is idealistic in romance and sentimental about the past. Antiques hold real appeal as tangible links to the 'good old days' and retaining all manner of mementos and keepsakes also adds to Cancer's reputation as something of a hoarder. Quietly rebellious at times, they were likely to have been regarded as a goody two-shoes in their teens due to their caring nature and dislike of direct confrontations. Loyalty to family and friends is important and similar loyalty is required in return. On the negative side, Cancer is sometimes regarded as moody and, in extreme cases, thought to be dealing with pent up hostility. It's important for those born under this sign to choose environments well because of the tendency to resonate with surroundings. Cancer will likely find locations by the sea particularly energizing and inspiring.
The creation of the constellation Cancer is explained in Greek mythology by the short-lived association of Karkinos (a giant crab) with one of the Twelve Labors of Hercules. While Heracles was fighting the multi-headed monster called the Hydra, in the swamp near Lerna, Hera sent Karkinos to distract Hercules and put him at a disadvantage during the battle. Karkinos emerged from the swamp and added its own attack by biting Hercules on the foot. Heracles angrily stamped on the crab, crushing it. For this modest contribution to history, we are told that the goddess Hera, the enemy of Hercules, put the crab among the stars of the zodiac. Fittingly enough for such a minor character, it is the faintest of the zodiac constellations. Some scholars have suggested that Karkinos was a late addition to the myth of Hercules in order to make the Twelve Labors correspond to the twelve signs of the Zodiac.


Sylvester Goh has found a 14 pound Gold Mission Unknown in Singapore.
The ball was purchased at Ken Pro Shop in Singapore. For the latest news on Gold findings, please continue to check www.ebonite.com/news.


Fixed price process from research to delivery.
Within a traditional Design & Build process the price and time span are fixed. It's transparent, reduces risk, and works best when the scope of the work and specifications are very clearly defined right from the beginning.
Before we start a Design & Build process, we implement a valuable Discovery Phase to understand the scope of the work. This will result in a fixed price and time span that is precise and realistic. More importantly, you won't be saddled with any extra costs along the way.
As processes go, we think this is the ideal way forward for our branding services as well as smaller digital products. It's less appropriate for digital products that require lots of iteration and prototyping. For these projects we recommend using a Continuous Process that allows for more prototyping and quicker ideation, as well as extensive user testing.
We've modified our waterfall process to reduce risk and improve results. By dividing phases into 'fixed' and 'flexible' we make room for more prototyping, iteration, and learning. This makes it a suitable tool for our small to medium size digital services, such as marketing websites.
Tip: It's not uncommon to start another Design & Development phase once new data becomes available. This makes it great for continuously adapting digital products.
A fixed price process is generally great for projects where the financial risk outweighs all others. Especially in government projects, where time-tracking is important (and sometimes mandatory) the scope has to be clearly defined and documented in advance. As a result, changes or additions aren't as prevalent. In this case a Discovery Phase which focusses on understanding the user and project goals is a great way to frame specifications and lay out a solid estimation.
Another example that would benefit a Design & Build process is one where a very clear idea of functionality, user needs, and goals (found through a Discovery Phase) is already in place. Based on your specific question, we assess if a fixed price process is the best option for your project.
Fixed price processes are especially good for companies with strict budgets which don't allow for unexpected costs (often found in Agile or Design Sprint projects).
The fixed price model is not suited for big digital projects, such as apps and custom back-end systems. These often change in scope based on prototyping discoveries and developments of fresh insight into user behavior. The fixed price model doesn't allow for these continuous developments, because of its predetermined budget. In cases such as these, we recommend considering a Design Sprint process or Continuous Process instead.


One of the best rule changes to come out of this Stellenbosch business?
The rule doing away with the silly "too many players in the line out" rubbish. I've seen so many teams in a position to put some serious points on the board only to throw it away because of one extra guy at the line out.
Don't you feel like is to small for this biotype of players?


This function returns the content of the actual node.
Only to correct a very small error, but maybe difficult to find in che function GetContentAsString posted by someone in April 2005.
There was $anode-node_value() instead of $anode->node_value().
$st .= $anode->node_name() . "='" .
$st .= ">" . $nodeText . "</" .
get_content() always returns UTF-8 (as should be!).
Seems that get_content() always returns utf-8.
Here's a routine I wrote that acts like get_content() but returns embedded XHTML in the string returned. I needed this as I was wanting to embed HTML formatting codes in my HTML (e.g., "<br />") and converting them to HTML entities or using CDATA was a huge hassle.


Discussion in 'Servos & Animatronics' started by Superman, Aug 26, 2011.
This is still a work in progress but I'm happy with the results and would like to share some of what I've been playing with.
Some of you would have seen these items at the Brisbane Mini but unfortunately I was unable to attend due to my little fall and they weren't operational.
I have 2 animated props on the go at the moment, One for Halloween and one for Christmas. The first one is a Skull that is mounted on a body. He is a completely stand alone motion activated prop. Here's what I come up with.
I purchased the skull from anatomy warehouse for about $25 for a forth quality one. BARGAIN.
The instructions for installing the servos into this exact skull are here.
The electronics for him consisted of 3 boards. The first 2 were to produce the audio and mouth movement and the 3rd one is to control his neck movement.
This Board from Cowlacious_Designs is basically a flash mp3 Player which can be triggered to play a single mp3 file once every time it's triggered OR it can even play a different mp3 file each time it's triggered which is the way I use it. When anyone walks past him he comes alive and sings a different song or tells a joke. I find it a bit better then just saying the same thing over and over again.
This Board also from Cowlacious_Designs is the second one in the group it takes Audio from any source (I'm using the 1st board for my input) and converts it to signal to drive a RC servo to create the mouth movement on the skull.
This Board from LOR is used to move his neck servos. It's capable of controlling up to 8 servos. My Servo dog board has a programmed 30 second sequence loaded into its memory and is triggered by a motion sensor to start its operation. It is currently only connected to 2 servos which control his head nod and tilt action a third servo will be installed to also get him to look left and right.
I'm curious how it "knows" to sing the main vocal versus the chorus (talking about the reindeer) - is there something you need to do on your part to differentiate them?
While the skull is fully automated and gets his jaw movement from the output of the mp3 board. The Reindeer isn't at that stage yet, He was driven by the servodog controller and a LOR sequence for demo purpose.
However to answer your question in a different way, Board 2 does have settings that it can either use left ,right or Both audio channels to drive the servo as part of its settings.
This Board from Cowlacious_Designs is basically a flash mp3 Player which can be triggered to play a single mp3 file once every time it's triggered OR it can even play a different mp3 file each time it's triggered which is the way I use it.
Just a minor correction (sorry Steve!) about the audio storage. This board uses an ISD "chipcorder" IC that stores the audio file(s) in a funky analog cell array. You can only record onto it via an analog input. The is no actual (mp3) file or way to digitally transfer an audio file onto the chip. You need to use a line level input. The playback quality is not hi-fi, but quite good enough for a simple talking effect like this.
I think I'll stop chasing the pixel push and move more into this area for next year. I already have a number of 'movers' mostly all powered by wiper motors. I like the use of a trigger for the walkers. I know the kids will get a kick out of them!!!
Great posts here. Keep them coming!
Thanks Dano. My Reindeer will hopefully be button activated for the kids. they really enjoy pressing things that are interactive. Keep an eye on this Thread. I can't wait for this to get the go ahead.
Steve, what a great marriage of electronics and mechanical animation! Very nice work!
I am sure all of your visitors ("big kids" and little kids alike) will really enjoy it!
Here's a quick video of Bucky all dressed up for his Halloween party.
SUPERMAN you are a bloody legend they are fantastic love both of them especially the reindeer head can't wait to see the finished product. Are you taking orders for next christmas yet hahaha.


text:
Words by Jono Kennedy
Infographic by Kevin Hawkins
Words by Zoe Efron, Kevin Hawkins, Michelle See-Tho, and Sean Watson
It's easy to feel selfish when you're a Farrago editor. Without meaning to boast, the four of us are lucky enough to be getting paid to do stuff we love—putting together a beautiful magazine, making up April Fools' Day scams, and exchanging our favourite Sandy Cohen quotes. But sometimes it's pertinent to stop and ask ourselves, "Is this job just a bit of a wank or are we actually doing something meaningful?"
We like to think that the third edition of Farrago for 2014 is a very meaningful publication. It draws attention to a range of important social issues, namely the harsh living conditions of asylum seekers and the struggles they face seeking refuge in Australia. The phenomenally talented (and ever-reliable) Cameron Baker has highlighted this issue with a thought-provoking front cover. We're also proud to feature Gajan Thiyagarajah's profile piece on Fawad Ahmed and Mohammad Ali Baqiri, two former refugees who are making significant contributions to their communities in Melbourne.
Our intention in publishing these pieces is not to push a political agenda, but to bring attention to the human side of this issue and add an important voice to the conversation. The same can be said about Christine Li's feature on the university's investment in fossil fuels, where she goes beyond the moral arguments to assess the financial feasibility of the university's current approach.
But, in true Farrago style, edition three doesn't just cover the serious topics; we like to think it's a lot of fun, too. Over the following 60 pages, Simon Farley attempts to play muggle quidditch, Jeremy Nadel joins the secret Cave Clan, and Will Whiten takes us through Myanmar. Oh, and Mia Abrahams helps us fulfil our number one goal for the year: publishing a Sandy Cohen quote.
Here are five things the four of us have argued about while making edition three:
The fine line between humour and racism: In celebration of the proposed changes to the Racial Discrimination Act, our original plan was to publish a piece arguing for and against being Asian. Kevin and Michelle, who between them are 150 per cent Chinese, thought the piece was hilarious. But Zoe and Sean (both white) vetoed that decision, fearing that some readers might find the piece racist.
Being partisan: The four of us each have strong political views. The question is, is it appropriate for us to yell them at our readers? Half of us shouted 'YES'. The other half whispered 'no'.
Letter of the month: Zoe wanted Z; Kevin wanted K; Michelle wanted M; and Sean wanted S. We settled with a happy medium: ö
Advertorial: We weren't sure whether it would be a conflict of interest for Kevin to commission a piece about Live Below the Line, the charity campaign that invites Australians to live on $2 a day for five days from 5-9 May. Kevin worked for the campaign last year. (Ed: and you can donate to his fundraising page at lbl.com.au/me/hihathawkins)
Who should write the editorial? As writers with big egos, we each wanted to be the author of this page. We even toyed with the idea of writing an editorial each and printing all four of them. For those of you playing at home, Kevin won this round. But the sentiments are shared by all four of us. Guess that's one thing we could actually agree on.
Zoe, Kevin, Michelle, and Sean
Words by Kevin Hawkins
If there's one thing to take away from Ronny Chieng's show Chieng Reaction, it's that the University of Melbourne is the fifth best law school in the world. Throughout his set, Chieng feels no hesitation in labouring this point, eager to remind the audience of his academic credentials.
Chieng's unashamed arrogance is part of his comic appeal. He presents himself as far smarter than the average person, and sets out to belittle those who can't match his wisdom. That said, you don't need to be a genius to enjoy Chieng's material. His rants about Asian parents, feminism going too far, public transport etiquette, and poor customer service manage to tap into universal attitudes and everyday situations. The only people who might feel a little peeved by Chieng's offensive are under 25s, a demographic Chieng dismisses for knowing nothing.
Inevitably, some won't be able to stand Chieng's self-righteous demeanour, or his overtly blunt delivery. He even acknowledges this himself by drawing an imaginary bell curve for his crowd (which incidentally draws more attention to his learned nature). But Chieng's show is hardly about pleasing everybody; indeed, Chieng clearly derives personal pleasure from gloating and complaining in front of a large crowd, and that alone is enjoyable to watch.
Ronny Chieng's Chieng Reaction is on at the Melbourne International Comedy Festival at the Hifi Bar until 20 April.
The only other time I've seen Lehmo speak at a live event was on 23 February, at the Reza Berati #lightthedark vigil. That evening, the breakfast morning radio presenter and refugee rights advocate gave an impassioned and thought-provoking speech, defending people seeking asylum. It was a breath of fresh air to hear an Australian personality uninhibited by the commercial or political pressures of television or radio, and just speaking their mind.
While Lehmo wasn't particularly funny that evening, his speech that night gave me the impression that he would be one person worth seeing at the upcoming Melbourne International Comedy Festival. I didn't expect him to preach his political values at his audience (only Tom Gleeson can get away with that), but I expected him to bring intelligence – or a sharp wit, at the very least – to his performance.
Perhaps my expectations were too high, but LEHMOOOO!!! (Get Involved) failed to deliver. While his set was amusing, one gets the impression Lehmo didn't work particularly hard on writing his material. He took aim primarily at the low-hanging fruit*: the Corby family, the Southern Star, his nagging girlfriend, cheap airlines, and bogans. I'd be lying to say I didn't laugh at anything, but there wasn't much in Lehmo's repertoire that I hadn't heard before. Perhaps the best way to sum it up is that Lehmo's best material was a running gag about cats, and a joke about MH370*.
Lehmo's formulaic routine certainly doesn't compromise the great work he does as an ambassador for Welcome to Australia, Make It Possible, and Live Below the Line – among other initiatives. But those hoping for something more intelligent than your typical stand up routine might be better off waiting around for the next asylum seekers rally.
LEHMOOOO!!! (Get Involved) is on at the Melbourne International Comedy Festival at the Melbourne Town Hall on 14 April.
If you voted for either the Coalition or the Greens in the last federal election, chances are that you won't appreciate all of Tom Gleeson's comic material. With mic in hand and audience at his feet, Gleeson's one-hour show Quality is an opportunity for him to speak about his political beliefs (and specifically his hate for Tony Abbott). And there's nothing the audience can do about it.
Two things save Gleeson from crowd heckling and mid-show walkouts. The first is that his show is part of the Melbourne International Comedy Festival, a cultural event in arguably Australia's most progressive left city. The second is that Gleeson is laugh-out-loud hilarious. Even if you're ideologically opposed to some of his rants, it's difficult not to appreciate his clever critiques of the government's demand for a surplus or their lack of action on climate change, not to mention his caricature of Tony Abbott as a bumbling idiot.
While politics is a prominent theme of his set, Gleeson is smart enough not to limit himself to that arena. Gleeson speaks in depth about his experiences as a parent, and is brutally honest about his struggles with alcoholism and his sessions with his counsellor. Gleeson's confessions may make some audience members a little uncomfortable; laughing at Gleeson's expense has more than a little bit of schadenfreude to it. But Gleeson's self-deprecating style and ability to read the audience means the show is more than just a sad AA meeting.
While converting his crowd into Labor supporters probably isn't Gleeson's intention, it wouldn't be surprising if a few audience members leave the show with a few reservations about Tony Abbott, or a few question marks over the Greens. In doing so, Gleeson demonstrates how powerful comedy is as a persuasive tool. While my personal allegiance to Sir Tony was not shaken by Gleeson's repertoire*, the quick-witted comedian nevertheless convinced me of his natural comedic talent. And for this reason I'd implore you to give him your vote.
*Disclaimer: Don't worry. I didn't actually vote for Tony Abbott.
Tom Gleeson's Quality is on at the Melbourne International Comedy Festival at the Melbourne Town Hall from April 10-20.
Welcome to episode two of Farradio.
Farradio is a monthly podcast, where the articles and issues of each edition of Farrago are dissected. Each episode will feature interviews and conversations with Farrago contributors, as well as some lighthearted banter and games.
In this month's episode…
Timothy McDonald opens up the long-lost Farrago fax machine
Sarah Dalton, Adriane Reardon, and Sean Mantesso discuss Scout Boxall's piece on heroin use and celebrities.
Sean Mantesso and Simon Farley chat about Ned Kelly and other Australian "heroes".
Farradio episode two
Produced by Ash Qama
Hosted by Adriane Reardon
Featuring Sarah Dalton, Simon Farley, Sean Mantesso, Timothy McDonald, and Emily Weir
Video edited by Kevin Hawkins
Music by destinazione_altrove (ccmixter)
Welcome to episode one of Farradio, the radio show… on camera… for Farrago.
Adriane Reardon chats to Matthew Lesh about his edition one opinion piece on the University of Melbourne's new smoking restrictions.
Timothy McDonald offers his three best tips for saving money at university.
Sean Mantesso chats to Simon Farley about his edition one Declassified piece about Vietnam draft dodgers.
Timothy McDonald tests the other presenters on how closely they read edition one.
Farradio episode one
Hosted by Timothy McDonald
Featuring Sarah Dalton, Simon Farley, Matthew Lesh, Sean Mantesso, Adriane Reardon
There are moments during Doc Brown's Of Mic and Men show where you might wonder whether you're at the comedy festival or in a lecture. Brown often goes minutes without telling a joke, using his set as a platform to discuss his views on race, politics, crime, and parenting in a slow and measured tone. His progressive values and open-mindedness are certainly welcome, but given the educated, cosmopolitan nature of the Melbourne audience, one could dismiss Brown for preaching to the converted.
Brown's tendency to take long pauses and walk around the stage aimlessly means that his punchline per minute ratio is lower than many of his compatriots. But if you prefer laughs to lessons, don't worry; Brown is still a funny man. Even when discussing serious topics, he finds a way to make his spiel entertaining, including a bit of irony here, and a verse of rap there.
With a background in hip hop, Brown hits his highest notes—and gets his best audience reactions—when breaking into rhymes. If the noise generated by the audience is any indication, one suspects they wanted more freestyling than philosophising.
Brown's style won't be to everybody's liking, but he brings an intelligent and thoughtful voice to an industry where it can be so much easier to appeal to the lowest common denominator. If less cultured members of the audiences can walk out of Brown's show feeling a little bit worldly—not to mention with a smile on their face—then it's fair to say he's done a good job.
Doc Brown is performing Of Mic and Men at the Melbourne International Comedy Festival from 27 March to 20 April.
As patrons find their seats inside the Lower Town Hall, the first thing they see is a small slip of paper. It invites the bravest of guests to write down their name, their occupation, and a funny story. These people and their stories form the basis of The Tim Vine Chat Show—a hybrid comedy show of pun-based one-liners, musical comedy, and conversations between Vine and his most willing audience members.
There's a lot of risk involved in Vine's approach. Thankfully he is not only hilarious, but experienced. He has a backlog of comic material he can retrieve at any moment, ensuring that his show does not fall flat even if his guests have nothing to offer.
On the night I attended, Vine had two types of guests: the straight guests, and the 'funny' guests. The guests who attempted to steal the limelight from Vine—in this case a broadcast announcer and an ex-circus performer—highlighted the vast cleavage between people who are funny and professional comedians. It was clear that Vine was not a fan of their over-the-top personalities and efforts to outshine him, and it was in these reactions that these segments found their humour.
In contrast, Vine's interviews with the straight guests were comedy gold. Vine has an innate ability to find humour in his guests' responses, or lack thereof, without personally attacking them. This might sound self-evident, but Vine understands humour and has an uncanny ability to force laughs out of his audience, even when the material at hand is weak.
The nature of the show means that every night will be different, and that judging Vine's tour on the basis of one night is partly unfair. Nevertheless, one suspects that Vine is comfortable regardless of who comes to the stage, and is confident enough in his own ability to improvise. For this reason, I would recommend against seeing one of Vine's live performances; seeing him at least twice would be far better.
The Tim Vine Chat Show will be performing at the Melbourne International Comedy Festival from 27 March to 20 April.
If Luke Heggie was the type of person who played amateur football—and it wouldn't surprise me if he was—he'd be the kind of player who sits at forward pocket, and spends the whole game sledging his direct opponent. Occasionally, he'd pop up to kick the odd goal, but his true value to the team would be after the day's play, when he unleashes a long list of cynical observations about the opposition.
In many regards, Heggie's comedy festival show Bush Week is itself a long list of cynical observations about a life's worth of opponents. And by opponents, I mean people that get on Heggie's nerves.
Over the course of his one-hour show, Heggie directs insults towards wanky tourists, bogan Australians, and his older brother. Many of the jokes—particularly those involving gender stereotypes—aren't particularly original, but they're nevertheless funny enough to generate laughs. Indeed, on the opening night, there were at least 10 audience members—albeit, 10 middle-aged women—who rewarded every one of Heggie's gags with a loud cackle.
While the majority of Heggie's stories work as isolated anecdotes, he does well to regularly return the conversation to his travel stories. Heggie takes the audience into his cheap backpacker accommodation, and introduces them to some of the more colourful characters from his journey. Next thing you know, he's having a rant about asbestos-free egg, or sharing his all-time greatest pranks. But without fail, Heggie is focused enough to return the narrative back to his hostel, providing some structure to a set that could otherwise be mistaken for a stream-of-consciousness dialogue.
Heggie brings his set to a close by performing a musical number with a stringed instrument from his travels. It's an unusual conclusion, especially given that his singing quality is not sensational, nor humorous, but somewhere in between. Nevertheless, the song—along with a set of good one-liners—gives the show a nice bit of closure.
Luke Heggie is performing Bush Week at the Melbourne International Comedy Festival from 27 March to 20 April.


Smooth and flowing, the GIORGIO Solid Surface Bathtub is inspired by the form of a river stone.
Cheviot solid surface bathtubs are crafted using the latest generation of composite resin materials to achieve a strong and elegant rim profile. Warm to the touch and possessing superior insulation properties, these bathtubs are ideal for those who prefer a long, hot soak. Inherently harder and stronger than acrylic, solid surface bathtubs are also impervious to creaking and flexing. Polished by hand to a glossy sheen, the material is stain resistant and easy to clean and maintain.


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By Pat Louise
WCS Joins Connected Community Schools
It's a complicated world teachers find themselves in as instructors.
In outlining how teachers and schools are called upon to do more than simply educate these days, American Federations of Teachers union president Randi Weingarten said her organization has found a way to support and supplement what is done in the classroom. "If we don't meet the needs of children how will we instruct in a high-quality way,'' she asked about 50 people last week at the Delta Lake Inn.
Weingarten came to Rome on a multi-purpose trip, including taking a look at the results in the Rome City School District where AFT has funded what was the Rome Community School program.
She also announced the financial support for the new expanded Connected Community Schools, with the Waterville Central School District, along with Town of Webb and Dolgeville districts, joining as the pilot expansion districts.
The program based in Rome is run by Melissa Roys, a Waterville Central School graduate who invited many of the program's 52 partners to the event. It was, she said, a way for everyone to be in the same room and understand the big picture of what is being done.
"You are truly connecting the community,'' Roys told them as she gave an outline of the success of the Rome program.
Roys, who has been leading the program for 18 months, said there are four pillars that define what is done. These are Expanded Educational Opportunities, Collaborative Leadership Services, Active Family Community Engagement and Family Support.
In Rome, the top needs were identified as …


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Hampstead DVD review
Diane Keaton & Brendan Gleeson star in this North London-set romantic comedy.
Jason Palmer
Credit: Nick Wall
Credit: eOne
Romantic comedies are usually only targeted at the 20-something market, so it comes as a very welcome and refreshing change to have Hampstead buck that trend. Diane Keaton and Brendan Gleeson are brilliant in this sweet, humorous and touching tale of second chances set against the backdrop of one of North London's most beloved areas.
The film is based (at times quite loosely) on the 2007 news story of Harry Hallowes, a recluse who fought for squatter's rights to a patch of land in Hampstead Heath which he called home. He took the property developers who tried to remove him to court to fight for his right to remain there. In the movie, Brendan Gleeson plays Donald, a cantankerous and fiercely independent man whose home is nestled deep in the Hampstead woods.
Emily, played by Diane Keaton, is a widow who lives in one of the fancy apartments in the area, and whose window overlooks the park. She is experiencing some financial trouble having been lumbered with debt from her late husband. One evening she witnesses Donald being attacked and calls for help. The two soon strike up an unlikely friendship, with Emily enamoured by Donald's straight-talking, honest personality. Before long she learns about the legal battle he faces to stay where he lives, so she helps rally local support to fight back against the property developers and the council to keep Donald in Hampstead.
The strength of the film lies in the rapport between Gleeson and Keaton. Both are excellent here and deliver performances that sparkle. The supporting cast are fine too with Trollied favourite Jason Watkins stealing his scenes yet again – this time as a smarmy accountant who takes a fancy to Emily. Lesley Manville does well as the busy-body neighbour of Emily's who has grand designs on her luxury apartment building. Hugh Skinner plays a wet but good-intentioned local activist and James Norton doesn't have a great deal to do as Emily's son.
I love London and I love rom-coms so when a film comes along that celebrates both, I'm fully onboard. Anyone that has ever visited Hampstead will love spotting areas that they have frequented in the film. Director Joel Hopkins (who is no stranger to the genre, having worked on The Love Punch and Last Chance Harvey) gives the film a nice visual appeal. He knows how to tap into the beauty of his surroundings and coupled with screen legends like Keaton and Gleeson, effortlessly conjures up scenes that delight.
Hampstead has a few problems with its narrative – the final third of the movie relies a little too heavily on the legal proceedings and more could have explored Donald's intriguing back-story a bit more, but it's of little consequence to have a romantic film come along to break the monotonous onslaught of summer blockbusters clogging up your local cinema. Hampstead is an engaging and at times very funny movie with plenty of heart and some wonderful chemistry from both its leads, and taken on face-value, delivers an enjoyable story.
Cast: Diane Keaton, Brendan Gleeson, James Norton, Simon Callow, Lesley Manville, Alistair Petrie, Jason Watkins, Hugh Skinner Director: Joel Hopkins Writer: Robert Festinger Released By: eOne Certificate: 12 Duration: 103 mins Release Date: 30th October 2017
In this article:Alistair Petrie, Brendan Gleeson, Diane Keaton, Hampstead, Hugh Skinner, James Norton, Jason Watkins, Joel Hopkins, Lesley Manville, Simon Callow
A celebration of the cult TV series in large format hardback book.
Greg Jameson7 days ago
Find out all the details for the eagerly awaited new album.
Pip Ellwood-Hughes7 days ago
The album accompanies her forthcoming book with James Patterson.
First single "Everything She Ain't" is out now.


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The Hyannis International Film Festival is an idea whose time has come. The festival will bring visitors from all over the world to vibrant Hyannis, Cape Cod's largest town, to enjoy a multi-day film event in the Fall that will fill the streets with filmmakers and film lovers and become a cultural mainstay.
An international film competition for feature length and short films with entries coming from all over the world through online film festival submission platforms Film Freeway and Without A Box. (screenings at Main Venue)
A separate showcase for regional filmmakers featuring films made in New England. (screenings at Main Venue and other locations, including outdoor screenings)
Year-round film and filmmaking education, consisting of speakers, panels, workshops and screenings. (Main Venue and other locations)
At present there is no downtown Hyannis movie theater. An independent movie theater on or near Main Street would bring year-round business to downtown Hyannis and could serve as the main venue for HIFF each year.


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Fishing: Panfish
Science Reveals Bluegill Secrets
Steve Quinn - January 21, 2014
This ubiquitous panfish is a biological marvel, honed by selective forces to be a survivor, a reproducer, and more — an exciting gamefish and worthy adversary. And at no time is that truer than below the ice. Because the bluegill is so common and able to exist in a range of habitats, many scientific studies have been conducted with them. At least one scientist has labeled them the lab rat of the fish world. In his book, Bluegills, Biology and Behavior, Stephen Spotte of the Mote Marine Lab in Florida, has reviewed hundreds of these studies and presented fascinating facts about this favorite fish. The book is available from the American Fisheries Society, fisheries.org.
If you watch a 'gill closely (underwater or in an aquarium), you can see the marvelous way it uses its pectoral fins, located close to its center of mass, to scull back and forth. Watch it move forward, stop on a dime, turn around, or move in reverse. The fin rays pulse like a fan, but in complex movements that push water in uncountable ways. Countering movements of the left and right fins give remarkable maneuverability.
In addition to its fins, the round compressed shape of its body helps it make fast turns, stops, and other maneuvers needed to capture prey or escape predation, though at the sacrifice of speed. Less obvious but important to holding position is the fish's manipulation of the upper and lower lobes of its caudal fin, as well as the anal fin. Under control of the brain, fin rays control the position and shape of the fins. When swimming forward, the dorsal fin undulates continuously, creating thrust and a resulting vortex behind the fish.
These features make this species ideally suited to feeding on small, slow-moving objects at close range. Bluegills thrive among dense stands of aquatic plants, where they can pluck invertebrates from stalks or turn tail-up and feed on worms and small benthic creatures.
Sensory Perception
Hearing and Lateral Line: The bluegill's movements are directed by its brain, based on input from its complex sensory apparatus. They're considered hearing generalists, possessing no special adaptations to increase hearing range or acuteness, unlike hearing specialists like minnows, catfish, and characids. Yet, their sound detection is remarkable.
Minute hair cells in the inner ear and lateral line detect water displacement. At close range, neuromasts in the lateral line, running down the length of the fish, detect the velocity of water moving past, from underwater disturbances caused by other moving objects. The otoliths of the inner ear detect the fish's acceleration and help it maintain equilibrium. These related sensory systems work in concert so a bluegill is constantly aware of its position and speed, and that of stationary objects as well as other fish and creatures. They enable the fish to maintain its position in a group of fish, avoid obstacles, detect and capture prey, and avoid predators.
The lateral line's detection range is thought to extend no more than a few body lengths from the fish, being most effective within one body length. Using these senses, bluegills detect and presumably identify vortices created by the movement of passing fish. The wake left by a swimming fish or other aquatic animal slowly attenuates, but not without leaving clues about its owners location and distance.
Some scientists have labeled these invisible trails "fish footprints" or "fish fingerprints." A study found that the wakes of pumpkinseeds in still water remained up to five minutes. Other studies have shown that bluegills can detect and approach small preyfish by following the hydrodynamic trails they leave. When bluegills' lateral lines were blocked by a cobalt treatment, they lost this ability. Researchers have postulated the lateral-line sense of bluegills is sensitive enough to detect swimming insect larvae, even in complete darkness.
Vision: Scientists consider bluegills a primary sight feeder, relying on vision heavily though certainly not exclusively. Because the ability to focus is related to the diameter of the lens, visual ability of bluegills improves as the fish grows. Dr. Keith Jones, chief fish researcher at Pure Fishing, reports that bluegill vision is rated high, compared to most other species, and similar to the largemouth bass. "The area of highest concentration of cone cells, those that enable color vision and improve visual acuity is called the fovea," Jones says. "The location of the fovea tells us about the direction a species tends to feed in. For bluegills, the fovea is somewhat toward the upper part of the retina, suggesting that they see best when tilted downward slightly." This is a position they often feed in, especially when browsing among plants, and it would be beneficial for bottom-feeding as well.
"Bluegills have two types of cones that peak in the range of green and red areas of the spectrum," Jones says. "This red-green combination is well matched to a daytime existence, enhancing contrast at dawn and dusk to increase feeding efficiency near the surface, while also increasing vision in deeper water during midday. Like bass, they seem to have little discrimination in the blue range. And they seem to have no capability to detect UV light. As for polarized light, early field studies suggested they were sensitive to it, but physiological studies have found no mechanism for this ability."
This cone pattern also helps them detect prey against the generally yellowish-green backgrounds they encounter in many waters far better than most freshwater species. This ability to heighten contrast is particularly helpful when feeding on nearly transparent zooplankton in open water.
Bluegills also excel in accommodation, meaning that they can extend or withdraw the lens of each eye to better focus on near objects. This movement is like the lens adjustment on an SLR camera, which focuses clearly on objects at varying distances as the lens is moved in and out. At close range, the lens protrudes toward the fish's snout, providing good discrimination of small nearby objects, such as zooplankton. These adaptations make the bluegill most adept at detecting small mobile prey in bright environments.
Their ability to find prey, particularly small ones, is reduced as turbidity increases and light levels decline. Field studies and lab experiments indicate that bluegills sometimes forage after dark, likely relying on their lateral line and inner ear systems.
Taste: According to Jones, bluegills have a sophisticated sense of taste, surprising given their habit of nibbling on the toes of bathers. Indeed, bits of dead skin might not be so distasteful as humans find them. "In our lab tests," he says, "bluegills are more sensitive to taste than crappies or largemouth bass. But in general taste preferences, they are similar to bass."
While some might find this surprising, there's considerable overlap in diet, especially when you consider fry and fingerling stages. "Overall, taste is phylogenetically conservative," he adds, "meaning that the genes that control taste do not vary greatly among closely related fishes, such as those in the centrarchid family. The sense of taste is under strong genetic control."
Jones' research has sought to define organic flavors and chemical classes, such as amino acids, that a species prefers. "Once we find the flavors they like, we can spike synthetic materials with high doses of those flavors and come up with baits that are preferred over food that they eat in nature." These findings have been used to create many of Berkley's successful panfish formulas in the Gulp! and PowerBait lines.
Bluegills are highly opportunistic feeders, especially when you consider the size of their mouth. Compared to the closely related pumpkinseed, their mouth is better suited to feeding on plankton. Pumpkinseeds have pharyngeal pads covered with flat, grinding teeth that enable them to crush and eat snails and mussels, but the pads of the bluegill are covered with fine needlelike teeth best suited to feed on small soft prey.
In addition to plants and many types of zooplankton, they consume great numbers of larval forms of aquatic insects, from gnats and flies to dragonflies and stoneflies. They also eat eggs of their own species and any others they can find, along with aquatic invertebrates including small crayfish and snails. Bluegills consume considerable amounts of aquatic plants in some waters, including pondweeds, cattails, elodea, and filamentous algae.
To ingest prey in open water, bluegills rely on suction feeding. To do this, a fish rapidly opens its mouth (less than 1/25 of a second), creating negative pressure as the mouth cavity expands, which causes a stream of water to rush into its mouth. If a prey item is caught in the stream of water, it's eaten. Observations even indicate that this inrush of water is capable of dislodging creatures clinging to sticks or plants. Studies comparing the feeding of bluegills and bass found bluegills about twice as efficient at capturing their target.
A study done during winter in Michigan found that bluegills reduced food intake considerably during winter. In early winter, they relied on mayfly nymphs, turning to Cladocerans, a type of zooplankton, in mid-winter, then insects at late ice. In mid-winter, bluegills ate more midge larvae that mayfly larvae. Overall feeding declined from early winter to mid-winter, rebounding in late February and March.
Next time 6-inchers surround your ice hole, don't disparage the little bait stealers, but watch their remarkable ability to sulk close to a lure, stare it down, then dismissively blow it off with a sudden blast of water. And sometimes, pulling a bait from a flock of little guys gets nearby bulls, lurking in the vegetation, to rise up and check out the action.
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Does B-Hub provide space where I can meet with my team to work on our business idea?
Do you work in remote villages?
Yes, we work in any localities of the West Bank.
Is my graduation project eligible for the B-Hub support?
Yes, if you plan to turn it to a real business and willing to commit your time to realizing this goal.
Does B-Hub provide seed funds or grants for startups or companies?
No, we do not provide any financial support, however, we will link you with the financiers best fitting your business needs and help with preparing all required documents for seed funds or loan or investment.
Can B-Hub write a business plan for my business?
We do not write business plans. Our experts will support you in the business planning and will help you develop the plan – you are the key decision-maker for your business. And remember, a business plan is only a document summarizing your business. What is really important is your full involvement into the business planning process.
Does B-Hub work with medium-sized companies?
Yes, our professional consultants are qualified to provide any type of business development services to any local company or international company willing to enter the local market. Services are chargeable; fees depend on the type of the services and level of effort required.


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Home Health Hinge-like protein may open new doors in cystic fibrosis treatment
Hinge-like protein may open new doors in cystic fibrosis treatment
In recent decades, treatment options for people with cystic fibrosis have improved dramatically. The newest drugs, known as potentiators, target a protein called cystic fibrosis transmembrane conductance regulator, which is mutated in people with the disease. Yet, while these medications can help some people with cystic fibrosis, they are far from perfect. Moreover, researchers haven't been able to figure out how the drugs actually work—until now.
A new study by Rockefeller scientists characterizes, for the first time, the interaction between potentiators and the protein they target at atomic resolution. The research, described in a recent report in Science, shows that two distinct compounds act on the same protein region—a finding that points to strategies for developing more effective drugs.
Finding the hotspot
The cystic fibrosis transmembrane conductance regulator (CFTR) is a channel that, when open, allows chloride ions to move in and out of cells. When CFTR is mutated, ions cannot flow freely, leading to changes in the make-up of mucus lining internal organs. These changes can be particularly dangerous in the lungs where they cause thick mucus to accumulate, often leading to impaired breathing and persistent infections.
Potentiators are used to increase the flow of ions through CFTR, ameliorating some symptoms of cystic fibrosis. Currently, only one such drug, known as ivacaftor, is on the market; another, called GLPG1837, is now in development.
"Ivacaftor can improve lung function by about ten percent. It can help a lot, but it's not a cure and not everybody responds to it," says Jue Chen, the William E. Ford Professor. "So there's a lot of interest in developing new potentiators."
Pursuing this goal, Chen and her colleagues investigated how existing potentiators work. They used cryo-electron microscopy—a technique that beams electrons at a frozen specimen to reveal protein architecture at an atomic level—to study the structure of CFTR attached to either ivacaftor or GLPG1837. Somewhat surprisingly, the researchers found that the two drugs bind to the exact same spot on the protein.
"These compounds are developed by two different companies and have very different chemical properties. But they manage to make their way to the same site," says Chen. "That tells us that this is a very sensitive, very important region of the protein."
Better drugs, more access
Upon analyzing the "hotspot" where the two potentiators bound, the researchers noticed a peculiar feature: This area contained unwound loops inside the membrane that signify a flexible structure. And this flexibility, the researchers realized, serves a practical function.
"The region we identified, it turns out, works as a hinge that swings open to allow ions through the channel—so its structure needs to be flexible," says Chen. "The compounds we studied bind to that very region, locking it into a channel-open conformation to improve ion flow. That's how they work."
With this knowledge, the researchers hope to craft compounds that directly target the hinge and do an even better job at keeping the ion channel open. And as Chen and her colleagues work toward the development of new drugs, she encourages other researchers to do the same. This kind of competition, she hopes, will drive down the cost of potentiators, making the medication available to a much larger portion of patients.
"We put our original data online and welcome anyone to use it," says Chen. "Because if more researchers use it, more treatment options will become available, prices will drop, and more people will be helped."
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Healing refugees' mental scars could help them build new lives
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Daylight Transmission
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Schools and media literacy critical for teen refugees' social wellbeing
A warming world notwithstanding, how does civilian space travel make sense?
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From anti-aging to the search for alien life, we promise to never bore.


Don't they look pretty holding hands!!
It helps that I now have a thimble. My finger was getting so sore but no more!
I'm hoping to maybe try to get some more fmq done tomorrow because there's been no progress on the 'Not So Charming Rainbow Stars Quilt'.
I gained a pound this week and am so fed up. I'm hoping it's water retention because I've barely been able to eat anything. Admittedly I've not done so much exercise (except normal looking after kids stuff) but who wants to work out when you're poorly??!
I'm on the mend so I promise no excuses next week and hope to see some loss.
Can anyone recommend some effective but gentle exercise? The next couple of days I want to go easy on myself (that makes it sound like I work out really hard, clearly I don't!! I just want a change and nothing too strenuous).
In other news... If you have facebook and fancy some free 'facebook cards' head over to moo . This is the UK site but I know the US one is doing the same thing (not sure about Canada or Australia or anywhere else, sorry!).
So incredibly professional and handy for handing out at all those important meetings I attend! HA! They're just for fun, I only paid a couple of pounds postage and I wanted to check them out. They come in a cute little case and you can chose 6 different images and get 50 free cards (for a limited time!). I have to say the images didn't come out as well as I'd hoped, the colours are pretty dull so if you're going to get some I'd say pick some really bright shots.
They do a lot of fun cards but I'm assuming the quality of the stuff you pay for is better!
Oh and look what my son made at school :) Happy Chinese New Year!
Hope you are feeling better soon, but even as a sickie you are productive! Your camera case is really cute! Unfortunately I don't have many suggestions on the exercise front...maybe yoga?
I love the camera case... how cute! And your starts look really nice. As for exercise, how about a nice walk?
I love that block...it is wonderful...hope everyone gets well soon!!
Rest up until you feel better- exercising when you aren't at least ninety per cent could see you have a relapse! Take it easy and make another Rose and Star!
Love your camera case - thanks for the tutorial! And thanks for the facebook cards tip - hope I can find the US site...feel better soon!
Love what your son made and your moo cards. I have mini cards for my etsyshop and got some free business cards too which I pop in with any orders I get. Not that I get loads but I just like them so much!! Love the blocks very modern and the Lark fabric is lovely.
Lucy the fact that you are doing anything when you are ill is amazing! Great handstitching - it's at times like these when it pays off! Love your sewing case and your rose star blocks!
The cards look good as does that dragon!
Hope you are feeling better soon! great camera case - a little thing I just did when she was napping! OMG, how do you do it? To be fair I would be napping too knowing me rather than sewing - hence the slow progress.
Hope you all feel better soon. Love the rose star blocks and the camera case. And the dragon is fabulous!
I really love your colour choices for the rose star block, they are very vibrant indeed!


Most of you know my son, Parker who recently turned 9 years old, and we very much enjoyed celebrating his sweet spirit and brave heart. He loves Disney's Cars, eating lots of pasta, listening to music, and really, really loves the ocean! There's no sweeter sound that warms our hearts than hearing his beautiful giggles throughout the day.
He is many wonderful things. Many of you may not know that he is also a child with severe autism and is still currently non-verbal. Autism is a bio-neurological developmental disability that becomes evident in early childhood. Individuals with autism struggle with verbal and non-verbal communication and also exhibit numerous physical disorders, including epilepsy, sleep disorders, anxiety disorders, digestive disorders, and allergies. 1 in 88 children in the US will be diagnosed with an Autism Spectrum Disorder (Centers for Disease Control, 2012).
It was a few years ago that I realized I needed to get back into shape. Raising 4 boys and practicing full time was tiring enough but I was always physically and emotionally drained. So with the help of a few neighbors, I started crossfit and running, moved to triathlons last year, and completed my first full Ironman Race last fall. The physical activity has been therapeutic for me and given me a chance to spend time with old friends and make new ones. Most importantly, my solitary morning trainings have been a time that I could truly reconnect with God and appreciate all the blessings and burdens He has provided.
On Sunday, November 16, 2014, I will be participating in my second Ironman Triathlon in Tempe, Arizona.
There is no cure for Autism. However, numerous educational, behavioral, biomedical, and related interventions have been proven effective in improving symptomology in individuals with this diagnosis.
I am fundraising on behalf of Train 4 Autism( T4A), a foundation dedicated to bringing together a community of athletes, physically active, and socially conscious people who are committed to raising awareness and funds for research and treatment for those living with Autism and their families.
Please join me in making a donation today. I am asking for donations of $14.06 to represent the 140.6 miles (2.4mile swim, 112mile ride and 26.2 run) I'll be covering this coming Sunday. As I race, I will be praying for Parker and all the amazing families we have met through this journey.


This episode's guest, Craig Haworth, is a youth sports coach who has a website that teaches other youth coaches to become better at what they do. He is also the host of the podcast "Winning Youth Coaching".
Is there a point when parents can become too meddlesome?
The universal traits of a successful coach that can be applied to any sport?


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EXPRESS SPORT looks at what could happen at Tottenham in the January transfer market.
Tottenham have out-run most of their Premier League opponents and have only lost twice so far this campaign.
Though their energy levels have dropped off in the past few matches, Spurs have one of the youngest squads in England's top flight.
Maurico Pochettino's philosophy has had the desired effect and he has rightly received the plaudits.
He has helped to shake off their inferiority complex against the big teams and made them mentally stronger.
Dele Alli and Eric Dier have been two of the club's standout players, and while Harry Kane has rediscovered his goalscoring touch after a slow start to the season, another striker is needed to take the burden off him.
Another centre-back would be handy, especially if Toby Alderweireld or Jan Vertonghen were to get injured.
A lot of fringe players were sold in the summer and their only big expense was £22million signing Son Heung-Min. There should be plenty in the coffers if Pochettino fancies bringing in another striker.
Saido Berahino has been touted as a possible target. Tottenham don't appear to be deterred after West Brom refused to sell the forward in the summer. Berahino has been frozen out of the first-team picture this campaign and he would give some Spurs some extra pace up front.
Chelsea have also been monitoring Berahino, so Spurs could face serious competition and it is thought they would have to pay upwards of £25m for his signature.
Andros Townsend's days at White Hart Lane appear to be numbered. He hasn't played for the club for nearly two months.
Newcastle and Aston Villa expressed an interest in Townsend before the start of the season, when he was thought to be valued at £12m.
However, he could now leave for a fraction of that price.


WILTON -- Wiltonian voices will be heard tonight as the dog leash and alcohol ordinances go to public hearing before the town's board of selectmen.
Both ordinances would expand on current statutes.
The revised alcohol ordinance would permit the sale of liquor in all restaurants until midnight on Friday and Saturday nights and on New Year's Eve.
The ordinance currently allows alcoholic beverage sales in restaurants until 11 p.m. in Wilton restaurants on Friday and Saturday nights.
A review conducted by the Wilton Chamber of Commerce found that nearby towns allow restaurants to serve alcohol until 1 a.m. on weekdays and 2 a.m. on weekends, in accordance with state law, and changing the law in Wilton may help business.
Currently, the dog leash ordinance states that owners must keep their dogs on leashes in Wilton Center, Schenck's Island, Town Hall, the Gilbert and Bennett School properties, all board of education properties, parks and recreation playing fields, and all public sidewalks and roadways.
The revised ordinance would expand those areas to Allen's Meadows and on Wilton trails.
Dogs in other public areas are not required to be on a leash but must be under control of the owner at all times.
There is a $50 fee for violating the ordinance.
The public hearings will take place at 7 p.m. and the board of selectmen will consider the amendments during their regular meeting at 7:30 p.m.


A ditched car marked the beginning of the dangerous leg of the journey. They progressed with care, but despite all, each hill proved to be worse and worse.
With no way to go but down, there was little choice but to knock on the door of Tim's neighbor. It was dark without lights, and the place looked sinister indeed.
Much running alongside the car, scooping/ swallowing ash, pushing, and praying, and they were back on the main stretch, headed homeward.
'Twas an adventure from start to finish: howling coyotes, sinister hermits turned friendly folks, doughty companions, some heart-stopping moments of fear and a warm and welcoming home at the end of it all. Thanks to God for keeping us safe through it all!
That is hysterical! The pictures perfectly match our adventure. I am so glad you took it upon yourself to make the memories of that night last a little longer. You were indeed a trooper-thanks for your great attitude!
I just love those pictures :)...and you too!
Ruth I love it! haha so hilarious! you really captured the feelings we were having :) and i love your art!
YES! Praise the Lord! And what a spectacular adventure it was indeed! I Love your pictures, rufus! Great job on the story in addition to your great example of perserverance and a positive heart throughout the whole matter.
I love you, my dear cousin!


I have about a year and a half of grad school left, and I want to start thinking about topics for my Master's thesis. My goal is to have one chosen by the time I go back to school in the fall (knowing the importance of this particular paper, I really don't want to procrastinate). The problem is, I have no idea where to begin. I have such varied interests when it comes to literature, and there's so many possibilities that my mind just freezes and I can't think of anything.
I love SciFi/Fantasy, so that seems like a good area to start. Perhaps something on Tolkien or C.S. Lewis, or maybe a more modern writer like Neil Gaiman? I've also considered something having to do with the role graphic novels have played in culture in the last 20-30 years. As a big fan of mythology another possibility I've though of is something having to do with how prevalent ancient mythologies (Greek, Roman, Egyptian) still are in modern writing. These are all very vague and random ideas right now.
Steering away from the fantasy genre, I've also considered something along the lines of Shakespeare and modern day, but although I love Shakespeare, it's such a vast topic and so many people have already covered so many aspects of it that it doesn't feel original enough to me.
If anyone has any advice on choosing topics (or even any suggestions on any topic) please feel free to share. I welcome any and all input, especially if it's actually helpful!


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Music release comments
2021 Grammy Awards Finally Done: See The African Artists Who Made Us Proud.
By Health360 (self media writer) | 1 year ago
The best Grammys in memory may have just revived the awards show. Trevor Noah hosted the 63rd Grammy Awards on Sunday, held outside Staples Center in downtown Los Angeles.
Damini Ebunoluwa Ogulu, known professionally as Burna Boy, is a Nigerian singer, songwriter, rapper, and dancer. He is one of the biggest and most successful African artists. He rose to prominence in 2012 after releasing "Like to Party", the lead single from his debut studio album L.I.F.E.
Burna Boy won Best Global Music Album for Twice As Tall at the Premiere Ceremony of the 63rd GRAMMY Awards. This marks his first career GRAMMY win. This is the first time a Nigerian has won from this category.
Ayodeji Ibrahim Balogun, known professionally as Wizkid, is a Nigerian singer and songwriter. One of Africa's biggest artists, Wizkid is the most decorated Nigerian artiste ever, and one of the most revolutionary Afro-pop artists of the modern era.
Beyonce's song, Brown Skin Girl, featuring the popular Nigerian artiste, Wizkid won the 2021 Grammy awards for Best Music Video.
Ghanaian superstar, Stonebwoy has congratulated Burna Boy and Wizkid for their Grammy awards victory while also praising Nigeria. This congratulation has turned to be something else for Samini which I will publish in my next article. Let all comment to congratulate them, they really made Africa proud.
Share this with your loved ones and friends.
Follow me to know more about the incoming Beaf between Samini and Stonebwoy.
Content created and supplied by: Health360 (via Opera News )
Damini Ebunoluwa Ogulu Grammys Nigerian Staples Center Trevor Noah


Doughnuts & Dragons, an artisanal doughnut shop and taproom, will open later this year at 3838 E. 82nd St. in the Clearwater Crossing shopping center on the city's north side.
It's the brainchild of Blake Dollive, who owns the business along with a minority partner, Mitchell Kunkle.The "doughnuts" part of the Doughnuts & Dragons equation will include both traditional sweet donuts and savory flavors to pair with beer. "Dragons" refers to the 100-plus board games that Dollive will make available for patrons to play while they're eating and drinking.
Dollive is working with a consultant to develop the doughnut menu. On the beer side, he expects to have between 30 and 40 beers on tap, with an emphasis on local and regional brews.
Dollive wants to open before this year's Gen Con event Aug. 1-4, an annual game convention that attracts tens of thousands of attendees to Indianapolis.
The combination of beer and doughnuts might seem unlikely, but it makes sense to Dollive.
The Purdue University finance graduate had intended to open a straight doughnut shop. "I've always enjoyed baking. My mom taught me to bake my own pies from scratch as a kid," he said. But in thinking of a way to differentiate the business, he realized that if he also served beer, he could capture both morning and evening customers. The shop will have equipment capable of producing small batches of doughnuts throughout the day, so that fresh product will be available into the evening.
The storefront property, which includes 4,117 square feet of customer space, has been vacant since BD's Mongolian Barbecue vacated it in early 2016. Doughnuts & Dragons will offer seating for about 130 patrons, including two private 20-person rooms that will be available for rental.
— Louisville-based LouVino will open March 5 in the mixed-use Penrose on Mass development at 530 Massachusetts Ave. The restaurant, owned by Chad and Lauren Coulter, offers Southern-inspired small plates and more than 60 wines served by the glass. It will be the second central Indiana location for LouVino, which opened in Fishers in 2016. IBJ first reported on the Mass Ave location in September.
— Central Indiana's first Taco John's is opening soon at 2004 N. Lebanon St. The Boone County restaurant is expected to open in March or April, followed by additional Indianapolis-area locations within the next few years, a company spokeswoman said. The Cheyenne, Wyoming-based fast-food chain has locations in 23 states. It currently has only two Indiana locations, both in Evansville. IBJ first reported on plans for the Lebanon restaurant n in 2017.
— Downtown restaurant Osteria Pronto, located on the ground floor of the JW Marriott, relaunched on Sunday with a new name—OP Italian—as well as a new dining concept and menu. The new menu is built around pasta, seafood, slow-cooked meats and Neapolitan-style pizza cooked in a new specialty oven. Osteria Pronto opened in 2011. Merrillville-based White Lodging, which runs the JW Marriott, developed both the Osteria Pronto and OP Italian concepts.
— Pizza restaurant King Dough opened Jan. 29 at 452 N. Highland Ave. in the city's Holy Cross neighborhood. It fills a long-vacant space that formerly served as a gas station and auto shop. This is the second location for owners Adam and Alicia Sweet, who brought in Reed Owens as a partner in the Indianapolis operation. The Sweets opened their original King Dough in Bloomington in 2015. IBJ first reported on King Dough in November.