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Home » A-Z-Search » Epigenetics
In the beginning of the twentieth century, developmental biology and genetics were two separate disciplines. The word epigenetics was coined by Waddington to link the two fields. Epigenetics literally means "on top of or in addition to genetics." It is defined as the study of mechanisms or pathways that initiate and maintain heritable patterns of gene expression and gene function without changing the DNA sequence.
Many human diseases are caused in whole or in part by environmental factors. It has been accepted that environmental chemicals can cause many of these diseases through changes in the genome (i.e., genetic effects). However, environmental chemicals can also cause effects in a variety of other ways. The study of these enduring changes, where life meets the genome, is epigenetics. Epigenetic discoveries have a great impact upon the understanding of child development, mental health, and how public health and well-being can be maintained in a changing world.
What id Epigenetic?
The term epigenetics refers to heritable changes in gene expression (active versus inactive genes) that does not involve changes to the underlying DNA sequence; a change in phenotype without a change in genotype. Epigenetic change is a regular and natural occurrence but can also be influenced by several factors including age, the environment/lifestyle, and disease state. Epigenetic modifications can manifest as commonly as the manner in which cells terminally differentiate to end up as skin cells, liver cells, brain cells, etc. Or, epigenetic change can have more damaging effects that can result in diseases like cancer.
In other words, Epigenetics refers to the addition or deletion of a methyl group to a DNA base, turning the gene on or off, or to packaging of the chromatin structure by silencing or opening regions of the genome by winding or unwinding the DNA around histones.
Epigenetic and developmental epigenetic changes happen in all humans as part of normal growth, development, and aging. Some of the changes can alter the risk of developing certain diseases.
At least three systems including DNA methylation, histone modification and non-coding RNA (ncRNA)-associated gene silencing are currently considered to initiate and sustain epigenetic change. Numerous researches are continuously uncovering the role of epigenetics in a variety of human disorders and fatal diseases.
DNA Methylation – DNA methylation is a chemical process that adds methyl group to DNA. This prevents certain genes from being expressed. Methylation can be transient and can change rapidly during the life span of a cell or organism, or it can be essentially permanent once set early in the development of the embryo.
Histone Modification – Histones are proteins that are the primary components of chromatin, which is the complex of DNA and proteins that makes up chromosomes. Histones act as a spool around which DNA can wind. When histones are modified after they are translated into protein (i.e., post-translation modification), they can influence how chromatin is arranged, which, in turn, can determine whether the associated chromosomal DNA will be transcribed. There are two main ways histones can be modified: acetylation and methylation. Acetylation is usually associated with active chromatin, while deacetylation is generally associated with heterochromatin. On the other hand, histone methylation can be a marker for both active and inactive regions of chromatin.
RNA-Associated Silencing – Genes can also be turned off by RNA when it is in the form of antisense transcripts, non-coding RNAs, or RNA interference. RNA might affect gene expression by causing heterochromatin to form, or by triggering histone modifications and DNA methylation.
Causes of Epigenetic Changes
Interactions with the environment can cause epigenetic changes that affect how the genes work. These interactions include behaviors like smoking, eating, drinking, exercise, and exposure to natural and manufactured chemicals in air, water, and food.
Environmental Factors – Environmental factors are one cause. These can include, but are not limited to –
High-fat diet – Studies show that pregnant mothers' high-fat diets to epigenetic changes and later development of tumors in their offspring.
Lack of essential vitamins and nutrients, such as choline, B vitamins, and folic acid. An NICHD-supported animal study linked lack of B vitamins and folate in pregnant mothers' diets with epigenetic changes, obesity, and heart disease in their offspring.
Intake of resveratrol – This substance, found in red grapes and red wine, may help protect against cancer.
Nicotine, the drug that makes cigarettes addictive
Chemicals in the living space or workplace – Asbestos, a toxic chemical that is sometimes found in older buildings. Bisphenol A (BPA), a chemical in many plastic containers, such as water bottles.
Heavy metals (e.g., cadmium) can disrupt DNA methylation.
Vinclozolin, a widely used pesticide, can alter DNA methylation in exposed laboratory animals. These changes persist in unexposed offspring through several generations.
Deficiencies in folate and methionine, both of which are involved in cellular processes that supply methyl groups needed for DNA methylation, can change the expression (imprinting) of growth factor genes
These environmental factors are only a few examples of things that can cause epigenetic changes. Many other environmental factors, known and unknown, can cause epigenetic changes.
Some epigenetic changes appear to happen on their own, without any clear cause.
Some epigenetic changes happen as a result of certain types of chemical reactions in the body. Even some genes contribute to epigenetic changes.
Cesarean Delivery May Cause Epigenetic Changes In Babies DNA – Babies coming into the world by cesarean section experience epigenetic changes, a study has found. So far there has not been enough follow up to know whether the effects are long lasting, but the discovery may explain the relatively poorer outcomes for babies delivered in this way. Cesarean delivery, where the mother's abdomen and uterus are surgically cut open to remove the baby, was once a last, desperate option. Studies found higher rates of methylation in stem cells from babies delivered by cesarean than via vaginal birth. Methylation of DNA affects whether genes are expressed or not within a cell and is the major path through which environmental factors can alter the expression of genetic traits.
Epigenetic Inheritance – It may be possible to pass down epigenetic changes to future generations if the changes occur in sperm or egg cells. Most epigenetic changes that occur in sperm and egg cells get erased when the two combine to form a fertilized egg, in a process called "reprogramming." This reprogramming allows the cells of the fetus to "start from scratch" and make their own epigenetic changes. But scientists think some of the epigenetic changes in parents' sperm and egg cells may avoid the reprogramming process, and make it through to the next generation. If this is true, things like the food a person eats before they conceive could affect their future child. However, this has not been proven in people.
Epigenetics and Diseases
Alterations in epigenetic pathways have been shown to be implicated in common human diseases
Common, chronic diseases of Western societies, such as eczema, asthma, diabetes, coronary heart disease, depression and cancers, are very different. They are nearly all multifactorial, so defining the cause is impossible. There are many contributing factors, including the person's genetic makeup. Imagine driving along a narrow, winding country lane in the rain, having just had a row with your partner. The windscreen is fogged up, and your car has rather bald tyres. You round the corner to find the lane blocked by a tractor backing into a field, and crash into the tractor. . A few examples are given below to illustrate the importance of epigenetic pathways in disease development.
Epigenetic and Cancer – The first human disease to be linked to epigenetics was cancer, in 1983. Epigenetic changes have been observed in virtually every step of tumor development and progression. Too little DNA methylation (hypomethylation) is believed to initiate chromosome instability and activate oncogenes.
A malignant cell can have 20- 60% less genomic methylation than its normal counterpart. Conversely, too much DNA methylation (hypermethylation) may initiate the silencing of tumor suppressor genes. Medical researchers are evaluating epigenetic markers as a means for early cancer diagnosis and prediction of clinical outcome. Therapeutics based on epigenetic strategies are also being considered for cancer treatment and prevention. How epigenetic changes may be a mechanism of environmental chemical-induced cancers is being researched as well.
Epigenetics and Aging – DNA methylation decreases as cells age. Identical twins are epigenetically indistinguishable early in life, but have substantial differences in epigenetic markers with age. This observation suggests an important role by the environment in shaping the epigenome. It has been shown that the process of aging involves some epigenetic pathways that have been identified in the process of carcinogenesis.
Epigenitics and Mental Retardation – Fragile X syndrome is the most frequently inherited mental disability, particularly in males. Both sexes can be affected by this condition, but because males only have one X chromosome, one fragile X will impact them more severely. Indeed, fragile X syndrome occurs in approximately 1 in 4,000 males and 1 in 8,000 females. People with this syndrome have severe intellectual disabilities, delayed verbal development, and "autistic-like" behavior. The syndrome is caused by an abnormality in the FMR1- fragile X mental retardation 1 gene. People who do not have fragile X syndrome have 6 to 50 repeats of the trinucleotide CGG in their FMR1 gene. Loss of this specific protein causes fragile X syndrome. Although a lot of attention has been given to the CGG expansion mutation as the cause of fragile X, the epigenetic change associated with FMR1 methylation is the real syndrome culprit.
Other human diseases – There is increasing evidence that epigenetic changes play a
critical role in the development of certain human diseases, such as, neurodevelopmental
disorders, cardiovascular diseases, type-2 diabetes, obesity and infertility.
Epigenetic Therapy
The use of drugs to correct epigenetic defects, is a new and rapidly developing area of pharmacology. Epigenetic therapy is a potentially very useful form of therapy because epigenetic defects, when compared to genetic defects, are thought to be more easily reversible with pharmacological intervention. In addition to holding promise as therapeutic agents, epigenetic drugs may also be able to prevent disease. However, epigenetic therapy has its limitations, such as the fact that both DNMT as well as HDAC inhibitors may activate oncogenes due to lack of specificity, resulting in accelerated tumor progression. The drugs include –
DNMT inhibitors (DNA demethylating drugs) – These drugs inhibit methylation of DNA by inhibiting the DNMTs. Most of the DNMT inhibitors presently available are not specific for any of the DNMTs. Inhibition of DNA methylation can be therapeutically useful in cancer where hypermethylation of promoter regions of genes is the most well established epigenetic change known to occur. DNMT inhibitors are also being investigated as a means to reactivate the methylated and silenced foetal haemoglobin gene in patients with thalassaemia and sickle cell anaemia in order to increase production of haemoglobin F, thereby helping in the correction of anaemia that characterizes these diseases. Some of these drugs such as zebularine and procaine are small molecule DNMT inhibitors.
Non-nucleoside analogue DNMT inhibitors – The myelotoxic effects of the nucleoside analogue inhibitors has encouraged the search for inhibitors of DNA methylation that are not incorporated into DNA because of structural differences from cytosine. These non-nucleoside analogue inhibitors are undergoing preclinical trials. Some of these drugs such as procainamide and procaine have the potential advantage as these have already been extensively used in clinical practice.
Antisense oligonucleotides – Antisense oligonucleotides are short, defined sequences of nucleotides that are complementary to mRNAs and hybridize with them and make them inactive, thereby blocking translation.
HDAC inhibitors (chromatin remodelling drugs) – These drugs inhibit HDACs, which along with HATs, help maintain the acetylation status of histones. The anticancer effects of these drugs are thought to be due to the accumulation of acetylated histones leading to the modulation of the transcription of specific genes whose expression causes inhibition of cancer cell growth. Some HDAC inhibitors such as suberoylanilide hydroxamic acid and depsipeptide have been undergoing. Some HDAC inhibitors such as suberoylanilide hydroxamic acid37 and depsipeptide38 have been undergoing.
http://www.nature.com/scitable/content/epigenetic-diseases-and-their-causes-and-symptoms-37397
http://science.howstuffworks.com/life/genetic/epigenetics2.htm
https://www.nichd.nih.gov/health/topics/epigenetics/conditioninfo/pages/risk.aspx
http://www.whatisepigenetics.com/dna-methylation/2/
http://www.zymoresearch.com/learning-center/epigenetics/epigenetic-biomarkers-treatments
http://www.iflscience.com/health-and-medicine/cesarean-delivery-may-cause-epigenetic-changes-babies-dna
http://onlinelibrary.wiley.com/doi/10.1002/047001153X.g103227/pdf


Southside Garden is a memory care provider in Hillsboro, GA. The staff at Southside Garden provide supervision and are able to remind residents to attend to activities of daily living such as grooming and toileting. There are activities appropriate for seniors with Alzheimer's disease and dementia that help keep residents active and engaged.
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Christos is a common Greek given name. In Greek, it may be spelled Χρίστος (Chrístos) or Χρήστος (Chrēstos), which are pronounced identically (cf. iotacism).

Derivation

Χρίστος

The Greek name Χρίστος is derived from the earlier word χριστός (note the difference in accentuation), meaning "anointed" and which became the Christian theological term for the Messiah.

Χρήστος

The spelling of the Greek name Χρήστος suggests a derivation from the word χρηστός, which in earlier forms of the language principally meant "useful", and in modern Greek means "ethical, righteous, good, just, upright, virtuous".

Transposition of accent

Transposing the accent to the first syllable distinguishes Χρίστος (Christos), the common name, from Χριστός, Jesus Christ. Similarly the given name Stavros (Σταύρος, Stávros) has the stress on the first syllable, differentiating it from σταυρός (stavrós), the Christian cross.

Constantine P. Cavafy gave two reasons for the transposition of the accent in the name "Christos": firstly, the rule of transposition of the accent from the final syllable to the immediately preceding syllable in ancient adjectives when they become proper nouns, "and secondly, the pious practice of differentiating in appearance from the divine epithet". Cavafy gave other anthropological examples of the need felt to distinguish between the "sacred" and the "profane", and university professor Giorgos Veloudis added tο Cavafy's examples the distinction between the "profane" word Σταύρος (the name "Stavros") and the "sacred" word σταυρός ("cross").

Veloudis also mentioned the reverse process whereby Christians have treated as "profane" the names of pre-Christian divinities such as Hermes, Artemis, Athena, Aphrodite, names used today by Greek-speakers.

See also
 , which includes people with first name "Christos"

References

Greek masculine given names
Given names of Greek language origin

redpajama_set_name: RedPajamaWikipedia


Editor's note: The following post was written by Data Platform MVP Sergio Govoni as part of our Technical Tuesday series. Mia Chang of the MVP Award Blog Technical Committee served as the technical reviewer for this piece.
In order to scale, it's imperative that companies stay ahead of competition. So how can they identify, store, manage and deliver goods to customers efficiently? The answer is: Barcode! A barcode is the graphical representation of a sequence of numbers and other symbols. The representation is made by lines (bars) and spaces. A barcode typically consists of five parts - and one of these is the check character, also known as the check digit. Handwriting this is a hard work, and is also susceptible to legibility problems. Barcoding dramatically reduces human error, recognition errors and transcription errors.
This article explores the algorithm needed to calculate the check-digit of an UCC/EAN barcode. It compares two possible implementations of the algorithm to calculate the check character for an EAN13 barcode using T-SQL language for SQL Server.
The UCC/EAN standard coding requires that every (well-formed) code ends with a check-digit that will be used by barcode readers to interpret the code properly. The check-digit is a number between zero and nine and it is calculated according to the other digits in the code.
The calculation algorithm requires that every digit in the code is enumerated from right to left, is shown here.
Subtract the upper multiple of 10 from the result obtained in step four. For example, if the result of step four is 47, subtract 50 from 47, so the result is 3.
If the result of the four step is a multiple of ten, the check-digit will be equal to zero. Otherwise the check-digit will be the result of the fifth step.
Suppose that your boss asked you to implement a T-SQL object, in an SQL Server database, that it is able to calculate the check-digit for a given EAN13 code. How can you translate the standard algorithm to T-SQL code?
One possible solution could be implemented by a user-defined scalar-valued function that receives an EAN13 code as input, and gives out the check-digit calculated for the given code. In reading the algorithm step-by-step, the most natural and obvious solution is implemented by the following T-SQL function.
This implementation of the algorithm to calculate check-digit works fine. If you try to calculate the check character for the sample barcode "801271210146" the function will return the number five, so, the check digit for the given barcode is five.
If you compare the result of the function -five - with the check-digit calculated by the GS1 check digit calculator, we observe that they are equal. The result of GS1 check digit calculator is shown in the following picture.
The first version of the function dbo.udf_get_check_digit_ucc_ean13 has been implemented with a row-by-row approach. But is it really the best solution? Let's think outside the code. The code is just a tool. We have to try to find out the logical solution and then translate it into T-SQL commands.
Usually, one immediately begins by realizing the first solution that comes to mind, and solving all the problems that arise - performance problems are the first type of issue that one usually takes on. But let's give up this approach and try to find the best algorithm (language-independent) that can solve the problem. This is called "set-based thinking". In chatting with Joe Celko, I found a set-based solution to implement the check-digit algorithm.
With the following, you can find the 2.0 version of the function dbo.udf_get_check_digit_ucc_ean13.
As the previous version, the 2.0 version of the function dbo.udf_get_check_digit_ucc_ean13 works properly, but it's better because it uses a set-based approach instead of row-by-row ones. And it also works fine on Azure SQL Database.
Barcodes offer companies automatic product identification, extremely fast warehouse movement and very fast data recognition and implementation. This means that barcodes improve productivity, and help companies save time and money. For each barcode that is generated (independently from the type: EAN8, EAN12, EAN13, EAN14, GTIN and SSCC) one has to calculate the check-digit, in order to add it at the end of the barcode characters.
In this article, we learned how to implement the check digit algorithm with T-SQL language using a user-defined function, saved in a user or system database in a SQL Server instance. We optimized the first version of the function using set-based theory. The function dbo.udf_get_check_digit_ucc_ean13 can be used directly in a T-SQL statement to obtain the check character of a given barcode.
Enjoy working with the EAN13 check-digit calculator!
Personally, I'm at a loss how anyone could consider the first version "natural" or "obvious". (The only thing really obvious about that is clearly a database server is the wrong platform for calculating a checksum).
However, the important note I want to make is that I don't see the second as being set-based at all. You are still essentially iterating through the string; you've just unrolled the loop (https://en.wikipedia.org/wiki/Loop_unrolling#Early_complexity).
Now, let's imagine that we have a table like such : CREATE TABLE Barcode ( digit int; weight int), and it is populate properly for this calculation (not sure how to do that without iterating over the string, but we'll hand-wave over that for now). Then we could calculate the sum with the query: Select Sum(digit * weight) as CheckSum from Barcode. That would be a proper set-based solution. For a true set based plan, each item should be independant of each other, and not care about their position. However, since the digits' position is the number is vitally important to the calculation, this calculation would be a rather bad example for showing set-base processing.
Thanks for leaving a comment here. We used the SQL Server function dbo.udf_get_check_digit_ucc_ean13 to calculate the check-digit of a given EAN13 barcode in every report that prints barcode on sticky labels for goods in the warehouse.
Yes, this solution is set-based, but what about Performance? There are barcode that have more than 13 digit and, in my opinion, store a row for each digit in a table is not a good solution! Consider, that we can generate thousand or hundred of thousand barcode every day, table-based solution will not scale properly in this case.
Given that, the rest of my commentary about the set-based calculation was just theortical, without concern for practicality or performance.
If you wish to speed up your own code, an inline table valued function will help.
If you have a Tally\Numbers table available, the second bit of code may outperform that too.
I hope this makes sense….
When I'm teaching people to move from procedural code to set-based code, I use this example. If they started with C as their programming language, then left to right scanning of strings was used in many of the classic textbook algorithms. In particular, converting a string of digits into an integer inside a loop (or recursively), or parsing a CSV string into local variables. Because of that, your first approach of looping seems natural to them.
I tell them to look at each position in the tag number string and what happens to it. The first thing is that it's sliced out, turned into an integer and multiplied by weight. Then all of the weights are summed. The next question is "how many of these operations can be done in parallel?" It quickly becomes obvious that multiplying by weights is parallelizable (is that a real word? Well, it should be), but summation is not. Summation only works on a completed set.
The other thing I really, really like about a declarative check digit computation is that I can move it into the DDL in SQL with a simple CHECK() clause. This means I don't have to keep doing the same code over and over and over. I can do it one place one way one time and be safe.


Western Ontario Warden's Caucus launches new web site to capture local broadband needs | Western Ontario Wardens' Caucus Inc.
The Rural Broadband Feasibility Study and re-launch of the WOWC website are part of the region's efforts to become an "Intelligent Community," a designation used by the Intelligent Communities Forum to describe communities that leverage high speed, high capacity information and communications technologies to drive economic development and promote job creation, diversity and innovation.
High speed internet access is a critical factor in ensuring Western Ontario can fully participate in the 21st century economy, often referred to as the "knowledge economy." With optimal internet speeds, individuals living in Western Ontario can do business with partners and clients virtually anywhere in the world while enjoying the lifestyle of their chosen community. Becoming an "Intelligent Region" means that Western Ontario will be able capitalize on opportunities to grow local businesses as well as attract community builders from across the sectors that have a significant impact on quality of life: health and well-being, entertainment and education, commerce and communication.
The Western Ontario Wardens' Caucus Inc. (the WOWC) is a not-for-profit organization representing 14 counties in western Ontario, the purpose of which is to enhance the prosperity and overall wellbeing of rural and small urban communities across the region. The members of the WOWC work collectively to influence federal, provincial and municipal legislative, regulatory and program initiatives through advocacy, research and analysis and education.


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Rose McNulty
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Rose is a freelance writer for The American Journal of Managed Care® (AJMC®), where she previously worked as an editor.
She has a BA in journalism & media studies and Spanish from Rutgers University. You can connect with Rose on LinkedIn.
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redpajama_set_name: RedPajamaCommonCrawl


The Hillsborough disaster inquest has ruled that the 96 victims of the football tragedy were unlawfully killed.
The jury has also ruled that there was no behaviour by football supporters which caused or contributed to the disaster.
After hearing more than two years of evidence, the jury of six women and three men have revealed their conclusions.
The inquests found the 96 football fans were unlawfully killed; fans were in no way to blame and that the police made major omissions and errors in their planning for the FA Cup semi-final and their response to the disaster.
The verdicts have vindicated the Hillsborough families who have fought for justice for 27 years against South Yorkshire Police's blaming of football supporters for the tragedy.
Emotional families at the inquest have reacted with cheers, applause and tears to the verdicts.


A couple of weekends ago, Robert and I both had the day off. So, we decided to take a walk to Pitcher Park. Pitcher Park is a quaint little park near "The Circle" in Orange.
We have walked to this park dozens of times, but this time it was different. As we approached the park, we noticed that a sweet and intimate ceremony site had been setup. There was a simple white aisle runner, with twelve white wedding chairs on each side, and two adorable topiary trees to mark the altar. I simply couldn't resist capturing a few photos.
As we were getting ready to leave, the details put together at the guest book table under the gazebo caught our eye.
Below are some of the adorable details of this beautiful and intimate wedding.
That old fashion tape player was the perfect centerpiece for this welcome table.
This is one of my favorite Bible passages. We included it in our own wedding.
Aren't these little Orange shaped candies adorable? What a great touch for an Old Towne Orange wedding!
Topiary trees were an element that I really wanted to incorporate into our wedding, but it didn't quite fit. They worked beautifully here.
What a precious and intimate ceremony site, beautifully lit by the golden afternoon of the July sun.


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Hocine Gherzouli, (Arabic:حسين غيرذل) is a Paralympian athlete from Algeria competing mainly in category F40 shot put events.

He competed in the 2008 Summer Paralympics in Beijing, China. There he won a bronze medal in the men's F40 shot put event.

External links

Paralympic athletes of Algeria
Athletes (track and field) at the 2008 Summer Paralympics
Paralympic bronze medalists for Algeria
Living people
Medalists at the 2008 Summer Paralympics
Medalists at the 2012 Summer Paralympics
Athletes (track and field) at the 2012 Summer Paralympics
Paralympic silver medalists for Algeria
Year of birth missing (living people)
Paralympic medalists in athletics (track and field)
21st-century Algerian people
Algerian shot putters


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[Press Release] Protect Human Health and the Environment from Persistent Organic Pollutants (POPs) | EcoWaste Coalition
#HumanRights #Health #Environment
Groups: Protect Human Health and the Environment from Persistent Organic Pollutants (POPs)
Environmental health groups today urged national and local authorities to give priority to zero waste strategies that prevent and reduce the generation of persistent organic pollutants (POPs), a class of highly hazardous synthetic chemicals.
The EcoWaste Coalition, Interfacing Development Interventions for Sustainability (IDIS) and Mother Earth Foundation (MEF) together made the call in observance of the 17th anniversary of the entry into force of the Stockholm Convention on POPs last May 17, 2004.
The treaty, which counts on the Philippines among its state parties, seeks to protect human health and the environment from POPs through a range of measures aimed at reducing and eventually eliminating their releases to the environment. Among these POPs are unintentionally produced pollutants such as dioxins and furans resulting from combustion and industrial processes, including the open burning of trash, the incineration of municipal, medical and hazardous wastes, and cement kilns firing hazardous waste.
"We call upon the Philippines as party to this treaty addressing global chemical pollution to prioritize zero waste strategies that are proven effective in preventing the formation and release of unintentional POPs, as well as greenhouse gas (GHG) and mercury emissions," said Thony Dizon, Chemical Safety Campaigner, EcoWaste Coalition. "While lauding the concerted multisectoral efforts dealing with POPs polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs), we also would like to find out where we are in terms of updating and putting our National Implementation Plan on all POPs into operation as part of the country's strategy toward sustainable development."
"Zero waste strategies, including waste avoidance and reduction, segregation at source, recycling of non-biodegradable discards, composting or digesting of organic materials, reuse and repair, extended producer responsibility, product redesign and clean production, effectively reduce pollution, while conserving energy and resources, creating jobs, and advancing community development," stated Sonia Mendoza, Chairman, MEF.
"In lieu of waste-to-energy incineration that is disturbingly being pushed in both houses of the 18th Congress and in some localities, we appeal to decision makers to divert their attention to mainstreaming zero waste strategies and action plans, with adequate budget support, to counter proposals to construct costly landfills and incinerators for burying or burning wastes," said Atty. Mark Peñalver, Executive Director, IDIS.
Promoting zero waste strategies — not the repeal of the incineration ban under the Clean Air Act (RA 8749) and the Ecological Solid Waste Management Act (RA 9003) – must form part of nation's priority efforts to recover from the dire impacts of the COVID-19 pandemic on people's health and livelihoods, the groups insisted.
According to the International Pollutants Elimination Network (IPEN), which includes the EcoWaste Coalition, IDIS and MEF among its members, "POPs are recognized as a serious, global threat to human health and to ecosystems."
POPs can remain intact in the environment for long periods of time, can travel great distances through air and water, can bio-accumulate in the food chain and can have adverse effects on human health and the environment.
Highly toxic to both humans and wildlife, exposure to POPs has been linked to the disruption of the immune system, neurological disorders, reproductive abnormalities, cancers and other diseases.
A living treaty where new POPs are added following rigorous review procedures, the Stockholm Convention started with an initial list of "dirty dozen" POPs. Currently, there are 30 POPs listed.
EcoWaste Coalition
78-A Masigla Extension, Barangay Central, 1100 Quezon City, Philippines
Phone: +632-82944807 E-Mail: info@ecowastecoalition.org
Website: http://ecowastecoalition.blogspot.com
tagged with EcoWaste Colaition, Human Rights, philippines


It's got style, All the space in the world for the Kids, A large Shed for Dad and even a Cottage for your Parents or Private Guests (bathroom disability friendly), In fact it's got Everything!
This lovely Family Home built in 2011 by the Multi Award Winning Kier Construction offers too much to mention but here are some of the features to feast your eyes on until you visit!
*	Gas stoves and water plus plus plus…..
Simply impossible to replace and ready to go!


text:
Judge commends former drug user charged in relation to friend's death
It's been more than two years since 26-year-old Clay Gorby was found dead in the shower of his home - a day Dutch Bess will likely never forget.
Judge commends former drug user charged in relation to friend's death It's been more than two years since 26-year-old Clay Gorby was found dead in the shower of his home - a day Dutch Bess will likely never forget. Check out this story on zanesvilletimesrecorder.com: https://www.zanesvilletimesrecorder.com/story/news/2019/09/04/judge-fleegle-commends-former-drug-user-charged-relation-friends-death/2202869001/
Shelly Schultz, Zanesville Times Recorder Published 4:00 p.m. ET Sept. 4, 2019
Dutch Bess, represented by attorney Peter Scranton, was placed on community control for three years for tampering with evidence after his friend overdosed and died in 2017. (Photo: Shelly Schultz/Times Recorder)
ZANESVILLE - It's been more than two years since 26-year-old Clay Gorby was found dead in the shower of his Zanesville home - a day Dutch Bess will likely never forget.
The judicial system made sure Wednesday, at least for the next three years, that Bess will be regularly reminded of that day as he serves his community control sanctions and pays for the young man's funeral.
On May 18, 2017, 30-year-old Bess and 24-year-old Dominique Harris were using drugs with Gorby when he overdosed.
Instead of seeking medical attention for him, the two men proceeded to clean the scene and place what could have been used as evidence into a safe before leaving the residence.
What could have been hours later, Harris called 911 using an alias and reported the overdose.
Both Bess and Harris pleaded guilty earlier this year to tampering with evidence - a crime lessened, according to Assistant Prosecutor John Litle, because evidence that could have been used to hold the men responsible for Gorby's death, was tampered with.
During sentencing Judge Mark Fleegle noted the seriousness of what Bess had done.
"There is an entire family out there that lost someone," Fleegle said.
Also noted was the actions Bess has taken in the past two years to change his life.
"Since this happened, you have successfully completed drug court in Perry County, you have a good job, you've done everything right," Fleegle said. Among the things Fleegle had to consider were to protect society, to punish Bess or to rehabilitate him.
"You're already rehabilitated," Fleegle said. "What do I do? Send you to prison and send you to rock bottom again. Drugs are just as available in there, and probably a lot cheaper."
Fleegle said his judgement was based solely on the time span since Gorby's death and the what Bess had done with that time.
"It's not often I get to see someone come into court who's turned their life around."
cschultz3@gannett.com
Twitter: @infoobtainer1
Read or Share this story: https://www.zanesvilletimesrecorder.com/story/news/2019/09/04/judge-fleegle-commends-former-drug-user-charged-relation-friends-death/2202869001/
Woman trapped in burning house on Fairview Lane
Former city auditor charged for petty theft
Landlord enters plea, forfeits property
Local News Briefs: Miller honored by fair managers
John Saunders: Changing the machining industry


Though glass Christmas tree ornaments appeared only as recently as 1848, there are few signs of the season as timeless as ornaments. With the Ornaments Soap Mold, you'll get three festive designs for the holidays including holly, snowflakes, and a spiral swirl.
COMMENTS: everybody felt in love with this shape soaps, truly ornaments add glitter to your soaps and you will have a beautiful sparkly ornamnet!
COMMENTS: Did not like as much as silicon mold. More difficult to release.
COMMENTS: I made beeswax ornaments for the tree with these molds, they are so cute and fun to be creative with!
COMMENTS: Really nice mold. Easy to color the swirls on the ornaments and then spritz with alcohol and pour on your next color. Pops out very easily. Has three cavities. Very pretty.
• Ease in use. Unique.
COMMENTS: Can't wait to use this mold. Definately will be a big seller!
COMMENTS: The cutest - just like little Christmas ornaments!
"Anyone know the measurements on the individual ornament soap?"
Staff Answer The dimensions of each bar are 3" x 3" x 1 1/8".


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How a 90's Best Seller is Helping Kids in Honduras Today
A pilot reflects on nearly twenty wears of sponsorship
Shelley Callahan | January 26, 2017 En Español
In 1997, Southwest Airlines distributed thousands of copies of Dr. Richard Carlson's bestseller, Don't Sweat the Small Stuff, to its employees — including pilot Don Wyatt of Palm Coast, Florida.
Inspired by the sentiment of the book, Wyatt wanted to give back. And since the late author was a strong supporter of Children Incorporated, Wyatt began to research the organization.
"There are many fine agencies to choose from, but my personal favorite is Children Incorporated… The experience has brought tremendous joy and satisfaction to my entire family."
– Dr. Richard Carlson
After thoughtful consideration, Wyatt signed on. He currently sponsors four siblings — three sisters and a brother. They live in El Progreso, Honduras, a town still recovering slowly from the destruction caused by Hurricane Mitch in 1998. Today, the population still grapples with the effects of homelessness, disease and continued poverty stemming from that natural disaster.
El Refugio Welfare Center opened soon after to provide a place for poor and abandoned children to go to for food, clothing, and educational assistance. The center provides for the children during the day and invites parents to become involved at the center by providing support in childcare, hygiene and healthcare.
A sponsor since 1999, Wyatt has consistently gone above and beyond to help provide the siblings with the essentials they need to succeed. He is currently paying for one to attend college and plans to help the other three when the time comes.
We sat down with Wyatt to learn more about why he chose to become a sponsor, and what he's learned along the way.
CI: How did you get involved with Children Incorporated?
DW: Like many other people, I learned about Children Incorporated though the book, Don't Sweat the Small Stuff. I acquired that book through my employer, Southwest Airlines, in 1997. The company thought so much of the book that they bought thousands of them for their employees. The book says to give back to others, and I was impressed with what the author said about Children Incorporated. I have contributed to other charities, and one of the things that I liked the most was that the money goes straight to the children.
CI: What do you know about Honduras?
DW: It was the first time I had been in Honduras in about three years. I am prior military and have lived all over the world. I am very familiar with how things are in underdeveloped countries. I have been to Korea and the Middle East, and I have seen poverty.
CI: What do you know about the childrens' living situation?
Mr. Wyatt with his family and sponsored children's family
DW: They live with their mother. She is the primary caregiver, and she has worked several odd jobs in El Progreso. Employment is hard to come by, so she has worked as a clerk in a grocery store, and a custodian at a hospital. But recently, the mother has had health problems. I don't know how she helped the children when they were not old enough to take care of themselves.
They live in a very rough part of town, and it is amazing that they have somewhere to live at all. They rent the home. For a while they were squatting in a home, and they got into the program because they found an empty home right next to the coordinator's home. She enrolled the children in Children Incorporated's program, and then they eventually moved into a home that they could legally pay for.
CI: What do you know about El Refugio?
DW: I met an assistant coordinator, Trenie, who always arranged for a translator and a driver, and has always met me, and spends the whole time with me and my wife, and going about visiting the children's homes. I have visited all of their schools, and I have taken them out to restaurants and water parks for a day of relaxation. The children are being provided for at the center after school with supplies, clothes and large bags of groceries on a monthly basis.
CI: What can you tell us about the children you sponsor?
The book says to give back to others, and I was impressed with what the author said about Children Incorporated. I have contributed to other charities, and one of the things that I liked the most was that the money goes straight to the children.
DW: Bernardo* was my first sponsored child, but he ended up dropping out of the program. I was asked if I was willing to sponsor a child in the same program in Honduras, which is when I learned about Samuel*. Over the course of a few months, I was told about some special needs of this family, and found out that he had three sisters as well. For about six months, I was only sponsoring Samuel, and then started sponsoring all the children — and that was in 2005.
Cándida* is the eldest of the four children. She was about eleven back then, and now she is 21. She is in her second year of the higher education program in university classes in El Progreso, where she studies information technology. When she's not studying, she spends her time listening to music and watching movies with her friends.
Right behind her is Mariluz*, who just graduated last December. She's also a movie buff. We got her a computer to help her with her studies.
Samuel is seventeen. He took an auto mechanics course in junior high school and is continuing his studies at a technical trade school, along with some regular classes.
Natalia* is the youngest. She's in high school. Like any other teenager, she likes movies and listening to music — but mostly, she looks for simple things to do that don't cost that much.
CI: Do you communicate with the children directly?
DW: Yes, I try to write them at least as often as they do, if not more — six to eight times a year, and then on birthdays and holidays as well. I tell them a little bit about my life and what I do, and I take pictures of the cockpit of the airplane and send those, and ask them about their health and happiness, and try to encourage them in school. I am hopeful that it will provide some additional opportunities for them.
CI: Do they write back? What do they say to you?
DW: The letters are normally eight to ten lines long, and they give a brief sentence of how they are doing. And then say they hope my family is happy and healthy.
CI: What advice would you have for someone reading about you and your sponsored children, and considering sponsorship?
DW: Children Incorporated is extremely responsive. They welcome inquiries, pass along concerns and are willing for me to get more personally involved with the needs of the children. I am very happy being associated with Children Incorporated, and I feel that the organization has a great history, and every dollar goes to the direct needs of the child.
People contribute to charities for a lot of different reasons. If you are the type of person that wants to become more involved on a personal level, Children Incorporated lets you do that. Often with other charities, you don't feel like you have a personal impact. With Children Incorporated, you can be more than just a contributor of money.
* Names changed for children's protection.
HOW DO I SPONSOR A CHILD IN HONDURAS?
You can sponsor a child in Honduras in one of three ways – call our office and speak with one of our sponsorship specialists at 1-800-538-5381, email us at sponsorship@childrenincorporated.org, or go online to our donation portal, create an account, and search for a child in Honduras that is available for sponsorship.
January 26, 2017 Education, Stories of Hope, Honduras
written by Shelley Callahan
Shelley is the Director of Development for Children Incorporated. She is also the lead social correspondent, regularly contributing insights through the Stories of Hope blog series. Sign up for Stories of Hope to receive weekly email updates about how your donations are changing the lives of children in need.
» more of Shelley's stories
More Stories of Hope
"I Won't Let Him Down"
Counting on friendships from across miles
Letters from Abel
A veterinarian shares her sponsor story
A Songbird in El Salvador
A young student at the Marillac School gets the chance to show off her talents


I decided on making a 'crumble' to ward off the outrageously cold weather here in Sydney. Granny Smith apples were peeled, cored and sliced, and steamed with a tiny amount of water. I folded in a jar of home-cooked rhubarb that I had taken out of the freezer, plus some sugar, and a good amount of zested lemon peel for an aromatic lemony zing.
Today I thought I'd commence a series of blog entries highlighting some of my kitchen equipment. If you're just starting a serious kitchen at home, or are just interested in seeing what bits of equipment other people have in their home, you might find this inspirational.
The other day I foraged my tiny patio garden for herbs and salad leaves to make a green risotto. It's winter, and most of my herbs and greens have died down. The patio garden photo above was taken in early summer last year. Anyway, there's always something growing out there.
I managed to find some decent rainbow chard (silverbeet), a last habonero chili that was hiding under foliage, two varieties of baby lettuce leaves, two varieties of rocket, some spearmint, vietnamese mint, some basil, marjoram, thyme and oregano, and some parsley.
This is a salad spinner. My old friend Tracey gave it to me as a present years ago when I was living in Perth. She was mad on Tupperware, and I was happy to receive this practical item from their range.
I filled the base with water, plunged the greens inside, sloshed them about and drained them. I repeated this until there was no more debris, then transferred the greens to the spinning basket, popped on the lid and spun away.
Centrifugal force spun out all the water and the greens were left completely dry. This piece of equipment is essential if you want to make a perfect salad and you don't always buy so-called prewashed leaves. I subscribe to the 'wash everything' mindset, so Mr Spinner gets well used.
I brought home a good-sized tray of red peppers (capsicum) the other day, and ear-marked them for oven-roasting. Early in the morning as the sun rose (the best time for doing ANYTHING, I cut them in half, took out their innards, pressed them flat and roasted them on a tray in the oven, finishing them off under the grill, until they were blackened and blistered.
I quickly put them in a plastic bag and allowed them to steam, then removed and peeled them, revealed their soft, bright, smoky-flavoured red flesh. After patting them dry on paper towel, I packed them into a jar and covered them with a good quality olive oil. There they will stay until needed for salad, pasta or pizza.
My father is a bit of a fan of stewed apples and custard – good Anglo-Saxon fare. So while the peppers were roasting, I peeled, cored and sliced some Granny Smith apples and stewed them with water, and when they were soft, I added a little raw sugar. My father likes them plain, so 'plain they is'.
On the other hand, I like aromatics, so while all the above was going on, I also poached a batch of peeled and halved pears. The sugar syrup was made fragrant with the addition of saffron, star anise, cinnamon and vanilla, along with a large strip of orange zest. They look very elegant, and their taste and fragrance is quite spectacular.
For all the friends and well-wishers of Sriman Yasomatinandana Prabhu, here are the details of his Memorial Festival.
Program: Homages, recollections, kirtans, feasting and more. All welcome.
On Sunday afternoon, after perusing the contents of my refrigerator and pantry, and noting that I was "cooking for one" (my son was eating out with his friends, and my father was too) I decided on following my appetite to guide me in a simple dinner menu choice.
When it's possible, I always try to follow these two ultra-simple rules of eating: 'eat when you are hungry', and 'cook what you feel like eating'. Life in all its complexities often make this very difficult to achieve, and sometimes it fails miserably. But sometimes I find myself able to fulfil these two great rules at once.
Ayurveda says to eat at the same time each day to promote a proper digestive regulation. My life varies from day to day so radically that this is often just not possible.
However, ayurveda-inspired common sense (and plain 'granny-wisdom') also says to eat when you are hungry. If you are hungry, you can digest well. It's as simple as that. If you can digest your food, you have a better chance of staying healthy.
And as far as cooking what you feel like eating (and thus simultaneously being in touch with your bodily needs and being in a good consciousness while you cook) you will be in a positive and pleasant mood when you eat. The result will be that you will also be best equipped to digest due to your good mental attitude. I learned this simple rule of eating from my Spiritual Master, Srila Prabhupada.
I oven-roasted chunks of orange sweet potato, and butternut pumpkin, and I also steamed some carrots. All orange vegetables, so they look quite similar in the photo above. I also added some steamed peas and cauliflower pieces, and a simple reduction of fresh tomatoes, garden greens, and marjoram leaves. A simple 'bow-tie' shaped pasta, known also as pasta farfalle, brought it all together, with a few gratings of kosher Grana Padano cheese, and a good slup of organic Australian olive oil.
My Dad likes to have soup some days for lunch, so I make big batches and fill single-serve containers for him to warm up when he wants them.
Today I found myself with a glut of vine-ripened tomatoes, so I decided to make tomato soup, the Kurma Cookbook way.
First step was to blanche the tomatoes – I cut out the cores and made a cross with a knife on the other end of each tomato. This ensures that the skins will lift right off in one piece when they are blanched in water. But you knew that.
The recipe calls for dried basil, but I still have a few leaves on my basil plants outside, so why not use them, I thought.
I melted a little butter, added cracked black pepper, a smidge of asafetida and the blanched, peeled and chopped tomatoes and basil leaves, along with a slurp of water.
A long slow stewing broke them down to a nice sloppy, soupy consistency. After cooking I inserted a bamix and pureed the whole mixture, added salt and a sprinkle of raw sugar, and returned it to a full boil.
I melted a tad more butter in another pan, sprinkled in a little flour, and made a tiny roux. I added the roux to the soup and again returned to a simmer, stirring all the while. Finally I poured the whole soup trough a seive and removed the seeds, peppercorn pieces and other debris.
I know it looks like pumpkin soup in this photo – just a peculiarity of the light. But I can assure you it's tomato – soupe de tomate de la journée!
I just saw my dear friend Dwaipayana for the first time since his horrendous bike accident three months ago. This photo was taken at Yaso's funeral. It was his first day out of hospital, and boy was he happy to see everyone. It looks like he'll be allowed to go home next week, all going well.
He even got to play his guitar and sing one of Yaso's favourite Mahamantra melodies in the funeral service.
Multiple breaks in his legs and steel plates and pins later, as soon as he can support his own weight, Dwaips is a free man. Well, as free as you can be in this world. There's months of physiotherapy to go, but anything's better than a hospital bed.
As his brother Tim commented (Tim teaches Ayurvedic cooking and plied his brother with nourishing food in hospital) 'Dwaips looks better than most visitors that come to the hospital, what to speak of the doctors and nurses as well'. Good to have you back with us Dwaips.


EIGHTY FOUR, Penn. — 84 Lumber announced its 2018 Rookie and Manager of the Year winners at the company's awards banquet Friday, March 8, at Nemacolin Woodlands Resort in Farmington, Penn. The two awards are the most notable of the annual ceremony, which honors 84 Lumber's top performers from the previous year, the company says. Other honorees included Area Manager of the Year, Buyer of the Year, Hauler of the Year and more. Various merit awards were also presented for best sales performance and improvement.
2018 Manager of the Year: Chuck Frerichs, Chandler, Ariz.
Chuck Frerichs and his family with 84 Lumber President Maggie Hardy.
Frerichs has managed the 84 Lumber in Chandler, Ariz., since it opened in 2005. Under his leadership, the store reached nearly $80 million in sales in 2018 — a $20 million increase from the prior year. Frerichs' hands-on approach has been instrumental to the store's growth, but he's quick to acknowledge that success is a team effort.
With 55 associates, 70 to 100 daily loads, and 15 delivery trucks, the store is poised for another strong year in 2019.
2018 Rookie of the Year: Nick Luchonok, co-manager, Oakland, N.J.
Nick Luchonok with 84 Lumber President Maggie Hardy.
Luchonok is 84 Lumber's third consecutive Rookie of the Year. After starting at the company in January 2018 as a manager trainee in Lords Valley, Pa., he was promoted to co-manager in Oakland, N.J., last August. Luchonok has brought an ambitious nature to his role. One of his primary goals as co-manager is to refamiliarize the store's contractor customers with counter service.
While he's currently focused on improving sales and operations at Oakland, Luchonok has aspirations of one day managing his own store. Dan Giacomin, Oakland's manager, believes he'll go far with the company.


On 30 November 2017, the Government announced a Royal Commission (RC) into misconduct in the banking, superannuation and financial services industry. Former High Court Judge the Honourable Kenneth Madison Hayne AC has been appointed as Royal Commissioner.
The Commission must submit a final report within 12 months.
The Government has stated that their current reform agenda including AFCA, super governance and ASIC reforms will continue.


text:
void main()
{
    // no char because char has unknown signedness (particularly, unsigned on arm64)
    signed char data;
    for (int i = 0; i < 100; i++)
    {
        // value of data is pseudo-random
        data = rand();
        if(data < 0) // avoid potential overflow
        {
            signed char result = data * 2; // WARN: potential underflow
            printf("%hhd\n", result);
        }
    }
}

redpajama_set_name: RedPajamaGithub


text:
Biography of William H. Gardner
Leave a Comment	/ Williams County / By Ohio Genealogy
William H. Gardner has found in his native county ample scope and opportunity for successful business exploitation and is one of the representative figures in the mercantile circles of the county seat, where he is president of the Bryan Hardware Company. He is a member of a family whose name has been identified with the history of Williams County for more than three-fourths of a century and was born on the parental homestead farm, in Center Township, this county, August 10, 1860, a son of Moses and Jane (Taylor) Gardner, who were born and reared in Pennsylvania and whose marriage was there solemnized. In 1842 the parents came to Ohio and established their home on a pioneer farm in Center Township, where the father reclaimed much of his land from the native forest and where he continued as a prosperous and influential exponent of agricultural industry until his death. He was a man of high principles and marked business acumen. He purchased land in the early days at a low price, and accumulated a large landed estate, which became very valuable with the passing years. He was an active advocate and supporter of the principles of the democratic party and was one of the influential and public spirited citizens of Center Township, of which he served as treasurer for a number of years. His devoted wife proved his able coadjutor in the achieving of independence and prosperity and their names merit a place of honor on the roster of the sterling pioneers of the county. Mr. Gardner died when about seventy-one years of age and his widow passed the closing period of her life at Bryan, where she died when about seventy-three years of age. Of their eight children three are living: Curtis D. is vice president of the Farmers National Bank of Bryan and is individually mentioned on other pages of this volume; William H., of this review, is the next younger, and Ira E. is a resident of the City of Toledo, this state; Mollie married Aaron Brannon and both are now deceased.
The invigorating environment and activities of the old home farm compassed the boyhood and youth of William H. Gardner, and he continued to attend the public schools until he had completed schooling in Farmers Center. That he made good use of these advantages is shown by the fact that he became a successful teacher and taught in the district schools during the winter terms for five years. He thereafter became the owner of an excellent farm of eighty acres in Center township, and he erected good buildings on the place, besides making other high-grade improvements and adding forty acres to the area of his farm. He continued his active association with the basic industries of agriculture and stock growing for ten years, and in 1892 he removed with his family to Bryan, primarily for the purpose of giving his children the advantages of the excellent schools of this village. His is not the nature that enjoys inactivity, and he has found ample demands upon his time and attention in connection with the substantial business of the Bryan Hardware Company, of which he is president. He has been an active and loyal member of the Bryan Business Men's Association and has given liberal support to its progressive policies and movements, which have proved specially potent in furthering the civic and industrial advancement of Bryan. Of this association he served for a time as president. His political convictions are indicated by his unfaltering support of the cause of the democratic party, he and his wife are zealous members of the Methodist Episcopal Church in their home city and he is serving as a member of its official board. Mr. Gardner is past master of the Bryan Lodge of Free and Accepted Masons, besides being affiliated also with the local chapter and council, and with the commandery of Knights Templar at Defiance, the while both he and his wife are members of the Order of the Eastern Star.
Mr. Gardner married Miss Blanche Tomlinson, who likewise was born and reared in Center Township, this county, and they have three children: Ethel, who was graduated in the Bryan High School and later in the Boston Conservatory of Music, has established and is successfully conducting a school of music in the State of Washington; Walter T., who likewise was graduated in the Bryan High School, is now manager of the Bryan Motor Service Company and the Auburn Garment Company. He is high priest of the Bryan Chapter of Royal Arch Masons at the time of this writing, in the spring of 1920, and is also worthy patron of the local chapter of the Order of the Eastern Star. He married Miss Bessie Updyke, daughter of Emerson B. Updyke, a representative farmer near Bryan. Harry W., the younger son, is the active manager of the Bryan Hardware Company, of which his father is president, as already noted. He likewise continued his studies in the Bryan schools until his graduation in the high school, and both he and his brother are numbered among the progressive and popular young business men of their native county. He wedded Miss Alice Killits, whose father is presiding on the bench of the Federal District Court in the City of Toledo.


text:
#ifndef _WX_CONTROL_H_
#define _WX_CONTROL_H_

#include "wx/window.h"
#include "wx/list.h"
#include "wx/validate.h"

// General item class
class WXDLLIMPEXP_CORE wxControl: public wxControlBase
{
    DECLARE_ABSTRACT_CLASS(wxControl)

public:
    wxControl();
    wxControl( wxWindow *parent,
        wxWindowID id,
        const wxPoint &pos = wxDefaultPosition,
        const wxSize &size = wxDefaultSize,
        long style = 0,
        const wxValidator& validator = wxDefaultValidator,
        const wxString &name = wxControlNameStr )
    {
        Create(parent, id, pos, size, style, validator, name);
    }

    bool Create(wxWindow *parent, wxWindowID id,
        const wxPoint& pos = wxDefaultPosition,
        const wxSize& size = wxDefaultSize, long style = 0,
        const wxValidator& validator = wxDefaultValidator,
        const wxString& name = wxControlNameStr);

    // simulates the event, returns true if the event was processed
    virtual void Command(wxCommandEvent& WXUNUSED(event)) { }

    // calls the callback and appropriate event handlers, returns true if
    // event was processed
    virtual bool ProcessCommand(wxCommandEvent& event);

    virtual void SetLabel(const wxString& label);
    virtual wxString GetLabel() const ;

    bool InSetValue() const { return m_inSetValue; }

protected:
    // calls wxControlBase::CreateControl, also sets foreground, background and
    // font to parent's values
    bool CreateControl(wxWindow *parent,
                       wxWindowID id,
                       const wxPoint& pos,
                       const wxSize& size,
                       long style,
                       const wxValidator& validator,
                       const wxString& name);

    // native implementation using XtQueryGeometry
    virtual wxSize DoGetBestSize() const;

    // Motif: prevent callbacks being called while in SetValue
    bool m_inSetValue;

    DECLARE_EVENT_TABLE()
};

#endif // _WX_CONTROL_H_


40. "The DISC program helped me a lot in getting a better understanding in why customers and partners say yes or no to certain proposals. Also internally where my USA colleagues are internal customers and partners, DISC can help you to understand them better and overcome cultural differences. Because these differences are present and if we do not admit this, a lot of time and money can be wasted.
4. "I use the DISC in two ways.


text:
The Blackest Spat
Linda Crispin
Tim Coad
Emma Magnusson-Reid
Natalie Mather
Eva Nilssen
Dexter Rosengrave
Date: 28-Apr-2018 – 27-May-2018
Vantablack was developed as a technology and introduced in 2014, but it became a known as a colour in 2016 and created controversy when UK artist Anish Kapoor was given sole rights for its use in art. Many in the art world took exception to the exclusivity of this agreement between Kapoor and Vantablack developer, Surrey Nanosystems, but none so much as Stuart Semple, a painter and printmaker, also from the UK.
A result of this very public spat has been Semple's Black 2.0, which uses a binding medium that is capable of holding more pigment than conventional binders, thus sucking in more light and resulting in the flattest, blackest paint available to artists. Semple rallied internet users in a social media campaign called #sharetheblack, and created his own pigments, which he then made available to anyone in the world – except Anish Kapoor.
For The Blackest Spat, curator Linda Crispin provided a select group of artists a quantity of Semple's Black 2.0. The artists have then responded not only to its unique qualities but also to the idea that the paint was created by a "punk reaction" – Semple's passionate defiance of Kapoor's exclusive right to a colour – aiming to create an exhibition through which, in their chosen media, artists can communicate resistance, defiance and opposition.
Curated by Linda Crispin for the 2018 CAT Curatorial Mentorship


text:
Marston Family Foundation Fund
Lee Marston's father was a preacher who instilled in him the practice of tithing and giving back to the community where one lives, works and raises a family. Lee and his wife Sylvia have lived their entire lives following these giving principles. "It's in everyone's best interest to give. I truly believe that if every one of us gave back, even just a little, the world would be a better place. Starting right here in our own community," says Lee.
Lee visited the Severn River for the first time when he was only three months old. His grandparents had a farm on the river and Lee was fortunate to spend his summers growing up there. As a young man, Lee remembers the Severn River as being clean and clear along with his love of fishing and catching soft crabs. Lee's early career took him out west and after moving his family back to Anne Arundel County, he noticed the river he loved had changed. It was muddy, the grasses were disappearing, and the blue crabs were dying. Something had to be done and he wondered how he could make a difference. Lee became the first Treasurer of the Chesapeake Bay Foundation.
Establishing a Donor Advised Fund at CFAAC was the ideal way for Lee and Sylvia to build their family's philanthropic legacy. Every year, Lee and Sylvia's children and grandchildren are each allotted a specific amount from the Marston Family Foundation Fund for grantmaking. During the winter holidays, the family gathers to discuss their individual philanthropic interests. The family's interests vary widely and include restoration of the Chesapeake Bay and its tributaries, AIDS awareness, education, food banks, gender identity and expression, and the healing arts.
Lee notes, "I just think it's important to do something to help what you love and what you believe in."


text:
Gazing into Hell's Mouth at Plas yn Rhiw
Surely Plas yn Rhiw is too lovely a place for visions of Hell? The ancient Welsh domain on the road to Aberdaron has a benign and slumbering air; here are gentle and delicate spirits.And it is not simply in the subtle shapes of the garden's planting or the soft hues and scents of fading flowers;
or in the cobbled paths and woodland walks where wild strawberries and ferns grow alongside fuchsias and hydrangeas;
or in the fabric of this old, old house whose stones reflect the end-of-summer sky and the steely blue-greys of the sea below.
Even the air around the house feels strangely soft. It is the kind of late September softness that makes you want to lie down in the grass and dream for days and years, listening only to insect hum and the chatter of sparrows. The setting anyway is blissful; all enclosed by woodland at the foot of Mynyth Rhiw Mountain, and embraced by the seeming sheltering curve of Hell's Mouth Bay (Porth Neigwl). So now you have it, an inkling that the tranquil surface overlays some deeper, darker currents.
Hell's Mouth lies on the southerly tip of Llyn Peninsula, overlooking the broader sweep of Cardigan Bay. The calm view from Plas yn Rhiw is transfixing. How can it have such a name? Yet watch this space and see a different scene. For when the south westerly gales come roaring in, this bay becomes a death trap. Over the years it is said that some thirty ships have been run aground, their holdfast anchors dragging before the driving storm. Wrecks include the Transit that foundered with a cargo of cotton in 1839. In 1840 it was the Arfestone carrying gold. An Australian ship was lost there in 1865, and in 1909 the sailing ship Laura Griffith was wrecked. And there is more.
Reel back to the 8-900s AD and Llyn was the scene of bloody raids. At this time the Vikings occupied coastal Ireland across the bay. Llyn was then part of the Welsh Kingdom of Gwynedd and Powys and its prominent position made it seem an easy target from over the Irish Sea. The Welsh, under Rhodri Mawr (Rhodri the Great 844-878 AD) fought valiantly to keep the raiders at bay, although accounts of the time attest to their terrifying attacks. But whatever the truth, the sight of a raiding party, sixty five ships strong, and coming fast into the bay must have truly chilled the blood. By the 10th century Llyn was still holding its own against Viking incursion, but only through constant vigilance. And this is where Plas yn Rhiw comes in. Local history has it that Meirion Goch, great-grandson of Rhodri Mawr, was instructed to build a fortified house at Rhiw and hold the coast against invasion. It is also thought that this stronghold occupied the site of the present house, although no provable traces have been yet been found. The descendants from this royal dynasty appear then to have occupied Plas yn Rhiw for the next thousand years, eventually adopting, in the English fashion, the surname Lewis. The Llyn Peninsula is the finger of land above Cardigan Bay. Hell's Mouth is due north of the 'd' in Cardigan. The port of Dublin in Ireland was founded by the Vikings, along with other coastal towns that they used as raiding bases. (Map: Creative Commons).
The house we see today, then, has its own stories – cycles of re-building, abandonment, decay, renewal. Now , as a National Trust property, it is frozen in time; as if its last elderly inhabitants, the Keating sisters, have simply popped out to the shops and left you to gaze upon their hats and gloves, and recently received letters. But more of these sisters in moment. First a quick history of the house. The lintel over the French window is carved with the date 1634, which probably marks the re-modelling of an existing medieval house by the then owner John Lewis. In 1820 the house was further extended and the grand Georgian facade and a further storey added. But in 1874 the long connection with the Lewis family ended and the house was sold for the first time in its existence. The new owner then let it to a succession of tenants, and it was possibly one of these, Lady Strickland, who created the gardens. She apparently also introduced the first bath tub to the district. And there is a tale of a ghostly visitation during her tenancy – a drunken squire roaming the house in search of a drink (lost spirits perhaps?). But by 1938, when the house was once more for sale, it was in a sad state of repair. The nearby millstream had left its bed and was running through the hall, rotting the staircase, brambles blocked the front door and the garden was a jungle. Enter the saviours, Welsh conservationist and architect, Clough Williams-Ellis (creator of Portmeirion ) and his friends the Keating sisters.
In this newspaper photo of 1960 (www.rhiw.com/) we see Eileen, Lorna and Honora Keating at Plas yn Rhiw. It is down to them that Llyn does not have a nuclear power station. They bought up coastal land to prevent it, and than gave the land to the National Trust. They also opposed overhead power lines and caravan parks, and in 1939 Honora received an OBE for her work for the National Council for Maternity and Child Welfare. They were the daughters of a Nottingham architect who was killed in a traffic accident when they were small. Their 32-year old mother Constance was left to bring them up, and she ensured, among other things, that they received a good education. Every year from 1904 the family spent their summers in Rhiw. In 1919 they bought a cottage above Hell's Mouth, and it was from here that they first saw Plas yn Rhiw. In 1934, after Constance became an invalid, the sisters settled permanently with her in Rhiw. There are tales of them shunting mother around the locality in a wheeled bed. By this time Plas yn Rhiw was abandoned, and although there were hopes of saving it, the owner could not be found. Then in 1938 a FOR SALE notice went up. Six hundred pounds was the asking price, and it was Clough Williams-Ellis who alerted Honora. He sent her a telegram: "Will you invest savings Plas". She replied: "Yes, but haven't got much."
The sisters bought the house, along with 58 acres of land that were all that remained of the original estate. With Clough Williams-Ellis to help and advise, the restoration began, and the following year the Keatings moved into the house. They then set about buying back the estate's former land, which they gave to the National Trust in 1946 in memory of their parents. The house was donated in 1952, although the sisters lived there for the rest of their lives, the last and youngest sister, Honora, dying in 1981. Inside, the house has no pretensions to grandeur, although it is filled with personal treasures – everything from fine Meissen figures to the cottage vernacular of a Welsh spinning wheel. Along with the family portraits and antique furniture are paintings by Honora who studied at the Slade, and also works by M E Eldridge, the often overlooked artist wife of the poet R S Thomas. (When Thomas retired from being parish priest at nearby Aberdaron, the Keatings leased to him Sarn Rhiw, a stone cottage in the grounds below the house).
The Yellow Bedroom
Honora's room – alongside the Victoriana there is in the fireplace a c.1916 Royal Ediswan electric fire which operated by means of 250-watt bulbs. Beside the bed is an early Pifco Teasmaid.
Today the National Trust is continuing to restore the house while staying true to the Keating sisters' aesthetic sensibilities and conservation principles. The garden has its striking seasons: carpets of wild snowdrops along the woodland walks in winter, a magnificently flowering Magnolia mollicomata in spring, the early summer azaleas, the September cascades of crimson magnolia fruits and fuchsias. So perhaps the final words should be left to Clough Williams-Ellis. In a letter that now hangs framed in the hall, he writes to the sisters: "In these serene spring days your little kingdom must be heavenly indeed."
Related: Arch Wizard of Wales: Clough Williams-Ellis Bright Fields on Llyn Warrior Wind-Singer of Llyn Post inspired by Sue Llewellyn's A Word A Week: Delicate
Posted on June 22, 2014 March 24, 2015 by Tish Farrell	This entry was posted in Heritage, photography, Travel, Writing and a Sense of Place and tagged A Word A Week Challenge, Clough Williams-Ellis, Cymru, gardens, Keating Sisters, LLyn Peninsula, M E Eldridge, National Trust, Plas yn Rhiw, R.S.Thomas, Vikings, Wales, wplongform. Bookmark the permalink.
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37 thoughts on "Gazing into Hell's Mouth at Plas yn Rhiw"
a fascinating history told so well in your hands and with marvellous illustrations to boot. All new to me so savoured every word – and the atmosphere you created
So glad you enjoyed it Laura. Thanks as ever for your comments.
Charlie clay says:
Visited this place this week a wonderfull story it's a magical place it touched me so.much so I went to the church where they are buried with there mother even the church was peacefull the door was open I went in and signed the book a beutifull story so close to ww2 and we'll done to the Gardener who is doing a really good job
Wonderful combination of history, people, nature, words, photos! Beautiful! Thank you, Tish!
You're most welcome, JF. Thanks for all those kind words.
Another fascinating post Tish which has set me thinking. I have a family photograph taken on a road above Hell's Mouth – there is my mother, my sister, and me, leaning against the car in a pretentious fashion (makes a change from gurning I suppose). I would be 9 or 10 which makes it 1960 or thereabouts, possibly earlier. The car was the family Ford Consul, reg – RMA 803 – now I must find the picture.
We had a Ford Consul too – cement grey. Yes, do find that pic.
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You have created a fascinating sense of history. How wonderful it must feel to walk through those beautiful gardens reflecting on the long and colourful history then to contrast the current tranquility with thoughts of hell and winter storms.
Thanks, Suzanne. It is a special place, and writing the piece has sent me off on a quest to find out more about M E (Mildred Elsi) Eldridge, whose work is hanging in the house and is now so little known, being eclipsed fame-wise by husband R S Thomas. She was a fine artist whose work I think you would like. Might be a post coming up soon.
Absolutely gorgeous photos and an utterly fascinating post, Tish. Thank you for letting me see this remarkable place through your eyes and words.
My pleasure, Babsje.
Beautiful place and so deserving of preservation!
Thank you for visiting Plas yn Rhiw, de Wets. Much appreciated.
Bits to Banjos says:
Digesting and enjoying this beautiful photography and these inspiring words as I look across The Menai Straits from Beaumaris. I am minded of so many people with more than enough money who could follow the sisters' example and save our beautiful acres from the clutches of greedy developers.
Absolutely, Bits to Banjos. Hope you're having a lovely time in Beaumaris.
A real beautiful and touching post, Tish. 🙂
Thank you, Celestine.
Another gem of a post. I adore your historical tales, Tish and the accompanying photos are beautiful.
I have a book titled Beautiful Britain by Bernard Miles that is written in a similar style. But your captivating prose get the nod. I don't know if you have anything in this vain in print but I'd bet you could write a winner in your sleep.
Thank you, kind sir. I do appreciate your appreciative reading of my stuff, Ark. You are a very nice person to write for!
I know we are told we must 'write for ourselves ' and all that but it's nice to know the hard work is appreciated.
Your description of the sisters reminded me of Ken Follett's WWII thriller,The Needle. ( worth a read by the way)
He describes a pair of elderly sisters living in a small cottage close to a railway. The imagery is similar.
Thanks for the 'good book' tip, Ark.
Very interesting post! I love the history of the house. Happy it's now frozen I time – and it truly looks like that!
It did have an 'Alice through the Looking Glass' sort of feeling. It would have been interesting to go into it without all the National Trust guides being there, and just sit and see what it had to tell us.
Oh, I would come with you 🙂
Now wouldn't that be fun.
What a lovely old characterful property, Tish. I visited the Lleyn Peninsula long ago but it's easy to imagine the raiders off shore. Sometimes I'm glad to be living in this century. 🙂
yes, Jo, we might gripe about this and that, but I definitely know I could not cope with Viking Raiders. And a lot of other things besides.
meadowstheweasel says:
I spent a lovely day on the beach in Aberdaron today, and drove back via Rhiw. I shall have to go and pay a special visit to the house soon. It looks wonderful.
Yes, it has a gently haunted atmosphere. The day we went was hazy, but on a clear day the view of Hell's Mouth from the garden would be worth a visit alone. Have a lovely visit.
wellhopper says:
Fascinating history – and I love your photos, they really capture the atmosphere of the house. Plas yn Rhiw is one of my favourite NT houses, one of the few I could imagine living in, in fact if it ever comes up for sale….
Still, we can all dream, I was there again yesterday, and found they've just added a tea room, what more could you ask for!.
Oh that sounds perfect. And yes, the house does just feel as if you could move into it. Thanks for the follow.
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There ought to be a facility to indicate the number of repeat visits. I must have read this at least three times.
What I find amusing is re-reading my own comments and the immediate thought always seems to be : 'Oh, I said it already.'
I'm not sure if this means I have no original thoughts or if the piece that sparked original one just stays burned in the memory?
It's just lovely of you to keep visiting. I award you three gold stars *** and 😀
I've mentioned before, I enjoy the way you ( surrepTish ously) lead your reader on with links to other posts.
Sometimes its ones' I have not encountered previously, others are more familiar. I for one always get a laugh finding I have 'been here before'.
SurrepTishious Tish, I like that, Ark. I'm glad you're happy to be sneakily led. I'm often quite surprised myself, having completely forgotten what I've written in earlier posts.
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No New Osbourne's Series Reboot. Sorry mom.
The Osbourne's were a ground breaking TV show. It was one of the first celeb-reality shows, showing a famous person in their "real" surroundings. Albeit with a few edits here & there to force something mundane to pass for entertaining.
If you've been holding your breath for a reboot of The Osbourne's I'd exhale if I were you. It's not going to happen and as with most things, it's for the better. Let's remember Ozzy for the good times. Let's remember Ozzy as the bat biting, rock n roll madmen we all know and love and are kind of afraid of. Not the bumbling, stammering, goofball TV dad that our sisters and mothers liked watching on basic cable.
Speaking of an Osbourne we're kind of afraid of...Ozzy's daughter Aimee released a super creepy music video.


Dr. Neri is a board certified orthopedic surgeon who attended Boston College for his undergraduate education and received his medical education at Loyola University Chicago where he was honored with induction into the Alpha Omega Alpha honor society. He completed his orthopedic surgery residency at New York University-Hospital for Joint Diseases where he served as an administrative chief resident and was awarded the resident teaching award. He subsequently completed an extra year of fellowship training in arthroscopic surgery and sports medicine at the prestigious Kerlan-Jobe Orthopedic Clinic in Los Angeles. During his fellowship he served as team physician for Loyola Marymount University, and associate team physician for the Los Angeles Lakers, Los Angeles Sparks and part of the medical staff for the Los Angeles Dodgers, Los Angeles Galaxy, Los Angeles Kings, Anaheim Ducks, Los Angeles Avengers and USC Football. He also received the Kerlan-Jobe Clinical Research Award for his research on superior labral tears in professional overhead throwers.
While he treats a variety of musculoskeletal conditions, his practice is focused on arthroscopic and reconstructive surgery of the hip (labral tears, femoracetabular impingement, gluteus tears, snapping hip), shoulder replacement surgery, rotator cuff tears and shoulder labral tears and ACL tears. He has published, lectured and instructed on the management of femoroacetabular impingement, hip labral tears, massive rotator cuff tears and superior labral tears in elite overhead athletes.
He is the head team orthopedist for the New York Islanders Hockey Club and orthopedic consultant for the US Open Tennis.
Dr. Neri is an active member of the American Academy of Orthopedic Surgeons (AAOS), International Society for Hip Arthroscopy (ISHA), National Hockey League Team Physician Society (NHLTPS), American Orthopedic Society for Sports Medicine (AOSSM) and Arthroscopy Association of North America (AANA).


There are still a few days left to enter to win a free session with studio two!
This entry was posted in Kids Photography and tagged biking family portraits, Fun Kids photography, fun outdoor kids photography, fun west vancouver kids photography, North Vancouver Kids Photography, north vancovuer outdoor kids photography, outdoor kids photography, Vancouver Kids Photography, West Vancouver Kids Photography. Bookmark the permalink.
Thank you so much! It was so much fun and I love all the pictures!


Not only am I a big fan of using software to get things done quicker and more precisely. Software has also given me a way to live for the last decade. From working at AOL when it came into Puerto Rico as a ISP (Internet Service Provider) to now running CIMA IT Solutions, technology has brought me a lot of great things and more importantly a reason to want to learn more and more on a the vast technological world surrounding us.
In my case it makes it easier because later on I can probably take something that was already created and tweak it. Instead of recreating it I can enhance it make it more functional.
I like to look for ways to make myself more effective and efficient. Although sometimes I run into a situation where I probably spent more time than if I would by testing a way to either make me more efficient or look for other options.
I can have multiple instances stored of whatever I am working on electronically. When you always have backups and also store a few remotely you end up having a copy of what has been done before. With paper once you lost it is gone. But it also takes a lot of space.
I remember in grade school where they always gave me a hard time because of my sloppy handwriting. I think over time it got worst. If you look at my handwriting now you can see that at 7 years old it was more attractive and pleasant. The keyboard has allowed me to communicate via writing so that others don't have a hard time understanding what I write. I am more than sure that other people can relate to this.
When your process is automated it allows you to share with many others. If you have a team of resources and want to share with them something remotely, having your processes automated or even better yet accessible online can improve productivity amongst teams.
I automated my billing to a certain extent with Freshbooks (Affiliate Link). I sit down one time and create a recurring bill that my clients receive every billing period. For a small business like me having software that helps me with billing is a life saving tool. Freshbooks even sends a reminder to those who have not paid you. If you are using other software where you have to manually input your recurring invoices over and over Freshbooks is a cost effective option that you can try for free with your first 3 clients.
Overall I see many opportunities for automating many things. The toughest part is dealing with people who are resistant to change and want to continue to do it the old way because they fear of failing when trying something new.
Since I love trying out new things I can clearly say that I am not afraid at failing when using a new technology or tool. Is you resisting change because of fear of failure? What is the worst that can happen you find out that the technology is not the right tool for you?
If you fear losing money make sure you have someone to ask about technology and how it can fit your organization. For many years I have been the vendor agnostic strategist making sure that what my clients implement will bring results.
Make sure you have someone you trust when asking about implementing new technologies. Even if you are hiring them to figure it out it can turn into a healthier implementation.
What things have you automated? What things do you see a purpose in automating?
Does anyone Enjoy Collecting Money?
Many of us small business individuals are far to lenient with our clients when they fall behind on their payments. We have to look for a way to get tougher with them.
Since I use Freshbooks I can set it up once and an invoice is sent out periodically. Another advantages of using Freshbooks as your billing system is that you can also track when they viewed the invoice.
If you meet with your client, give them a Letter with the Word Final Notice written as big as possible on the envelope. This is a good way to break the ice. I caught the idea from watching Bravo TV's Flipping Out. This sends a clear message that all work will stop if payment has not been received.
If you are not getting responses from your project manager, feel free to copy key people and top management (it works better if you know them). The more people you copy the more pressure you put on the person that has not paid their invoice.
I hate when people repeat the same thing to me and many people feel the same way I do. If you include the invoice on every other email they will start getting the message that you need to get paid.
If you have done the above, continue to remind them by following up every chance you get. The more time it has been that they owe me money the more times in a week I start contacting them about when I am getting paid.
I recommend doing this with your clients. At some point they decided it is not a priority for you to get paid.