This section describes how the create and work with documents. For documents shared on the WWW see the section World Wide Web.
The most known is WYSIWYG (What You See Is What You Get) or some programs do WYSIAWYG (What You See Is Almost What You Get).
An other goal that is on contradiction to the above is: Write a document once and use it everywhere. This concept allows you to have a version that you or a team of authors access where you can have an version control system. It can be exported to a web page in HTML so it can be read using a browser. Or exported to pdf to be sent everywhere and printed on paper.
The newest version (2017 Version 10) of Acrobat reader is not available under Linux. Working with older binary versions that require old libraries is not very recommended.
okular is a good alternative that depends on some but not too many kde libraries.
master-pdf-editor is very featured but it is not free and intended to be registered. However it can be run for free as unregistered version with limited functionalities. The limitations might still be more featured than many free versions.
There is Gsview a viewer for postscript. To edit pdf's pdf's can be opened with gimp, important is to set landscape or portrait correctly before importing the pdf. You can select multiple pages, but every page becomes a gimp layer.
As a Linux beginner I avoided emacs, since it looks old fashioned, ugly and bloated. However I ended up with many specialized editors: OpenOffice Writer, editor that come with the desktop environment, Lyx, HTML editors, … .
Instead of learning all those tools, it might be better to replace them by emacs. Since emacs is more than just an editor, it is more something as an IDE: It can be used to write and debug many things as c programs, xslt, bashdb and many more.
The emacs user interface is really not intuitive. Middle mouse clicks are used instead of double clicks and some keystrokes have to be known, even there is a gui. Open files are buffers, in the Buffers menu they can be closed. Alt+x (or Esc+x) makes M-x in the command line below. Add the following here: M-x fundamental-mode to get the major mode fundamental. Luckily the tab key completes text. There is also Crtl+x that is C+x. F1 + M gives a description about the active major modes.
There are two versions to choose from http://www.gnu.org/software/emacs/ (looks better) and http://www.xemacs.org (looks really ugly and old fashioned). Gentoo solves this by having a virtual emacs ebuild and a eselect-emacs ebuild. Emerge the emacs of your choice or both of them and do a eselect emacs list to see what you have got. And to switch between them.
Emacs was mainly written in lisp. You might come in touch with lisp when you do advanced things with emacs.
Libre Office is a fork from Open Office and is a free alternative to Microsoft Office. It runs under Linux but also under Windows. The latest versions can smoothly open Microsoft files and store them in then various Microsoft file formats as well. However it is more future oriented to store them in a open format. By the way,LibreOffice can also be used to help Microsoft Office users to open their files when they run in incompatibility problems.
Luckily, standards for the public are in preparation (Microsoft is involved, but probably due to the pressure received ) to define the file formats for office files. See http://www.ecma-international.org/ where TC45 - Office Open XML Formats creates the standard ECMA-376 that will be adopted by www.iso.org and www.iec.ch and will create an other incompatibility to Microsoft Office.
If you want to open a LibreOffice file on a Windows computer that hasn't LibreOffice installed you should look at https://portableapps.com/ where you find OpenOffice portable for Windows, that runs from your memory stick and does not need to be installed on the Windows computer.
Try to close and save open office files when you make some tests with device drivers and multimedia.
If you have a crash and you can not open a file anymore, you might consider to unzip the crashed LibreOffice file, a directory will appear where you might recover some data with XML format.
Insert Name Define => creates cell name other than e.g. A7 so constants can be picked from cells and used in formulas, without being overwritten by increments when copying.
Go to Tools => Outline Numbering to create numbers for titles (not other numberings as line numbering). This way you can create table of contents based on outline.
To have Hyperlinks in the table of context right click table of contents then select Edit Index/Table to get a menu. There go in the Entries tab. What then follows is a rather complicated procedure that can be read using the LibreOffice help.
Insert => Indexes and Tables => Entry and click to Insert (Using the default settings the word should be getting a gray background). Repeat until you are happy then click to close. Click there where you want to have the index and Insert => Indexes and Tables => Indexes and Tables. Select Alphabetical Index and click OK. To have two columns in the alphabetic index and save lots of pages do edit index table and set 2 columns.
Do not just select text and modify it with font, size color since this would be badly maintainable. Go in Format=>Styles and Formatting a window opens. To format text there are Paragraph Styles and Character Styles. Paragraph Styles format everything until a CR character whereas Character Styles can be used to highlight a single word embedded in text.
In this document I used custom styles to have all command lines using this style. If I find they are too small to big or can not be printed black and withe, I can change on a single location and do not have to scan manually throughout the document and do hundreds (or even thousands) of mouse clicks.
The manually caused formatting mess can be cleaned by selecting each manually formatted item individually and Mouse click right=>Default Formatting. This is an other reason why working with styles should be started right at the beginning.
When making a manual page break the page style of the following page can be selected. First page for the first and last page to create the cover, default page for the rest has been used in this document.
If AutoComplete is activated LibreOffice proposes some text before you have finished the typing, you can accept it by pressing the Enter key.
Pictures or other stuff can have captain assigned that allows to give them a visible title and border.
to have German Swiss spell check among English.
To make holes into a shape use combine.
To make complex shapes rectangular with round section draw them individually and then use merge shapes.
Don't do it with more than 2 shapes at a time.
To change the value of dimension, just select the dimension and type in what you like to see.
Lot of Linux tools make use of latex (pronounced like laitech), so you might get in contact with it and think is is old fashioned. You might get it confirmed when observing the latest release date.
jedit might be a good editor.
Similar to docbook, latex allows writing documents using a regular ASCII editor. Such files have tex extension and use its own syntax to make the text attributes (docbook uses XML for that). Latex can convert such tex files to dvi files that can be viewed (xdvi or kdvi) or converted to Postscript using divps. Latex can not be used on its own it requires something as a latex distribution containing fonts, and tools. Latex can be converted to HTML using latex2html or tex4ht or pdf using pdflatex.
Lyx has it own file extension *.lyx but allows latex source preview and latex export.
Lyx can be used for all kind of things. Start lyx go to the help menu and start reading.
If you want something other than English just change the language.
Start lyx from a console so you see what is going on.
If dvi preview does not run, try to open via file manager a dvi file to find out the name of a program that can do it. In xfce4 there is probably already evince installed that can do the job. To tell lyx to use evince as dvi viewer set it via Tools > Preferences > File Handling > File Format. Then select dvi and instead of auto set evince (or whatever name the dvi viewer has).
When you type, the characters go into an environment. The environment defines what the characters mean: Is it simple text, is it a title, a list, a comment, ….
Or set a split value bigger than 0.
https://www.wikipedia.org/ has demonstrated the success of wiki. Wiki uses its own markup language that is then converted into HTML to be shown using regular web browsers. Regular HTML browsers allow also to edit the text.
The term wikitext or wiki markup is used for the source of wiki. Wikitext is considered as simplified markup. There was no standard at the beginning to define wiki markup and some incompatibilities occurred.
A wiki software (wiki application or wiki engine) is used for the conversation. There are also creole to xhtml converters.
http://www.dokuwiki.org/ is a wiki that does not use a database.
https://www.mediawiki.org/wiki/MediaWiki is the fully blown wiki used by wikipedia that uses a database as mysql.
It is strongly recommended to consider how to backup your wiki, especially when you want to edit it on the web and give others permission to do so. Also security issues have to be considered. Making a backup of a full blown database based wiki is much more complicated than using a filesystem based wiki. If you read "I lost my wiki database", then this means all the work is gone.
There are incredible many different wiki's checkout http://www.wikimatrix.org/ what wikis exist and what they can do and require.
The standard way is to convert wiki data into HTML, however wiki data might get also exported to other formats as pdf or xml.
http://www.dokuwiki.org/ uses a directory where the stuff goes and does not use a database. It is therefore easier for the backup and has a lot of plugins that can expand its functionality. File synchronizers as unison can be used to synchronize and backup dokuwiki when it is present on the machine or the wiki files can be accessed via a file system.
php needs to be installed. Before emerging dokuwiki it must be decided how it should be installed. Two ways exist just install to one server or when your PC has multiple virtual servers, just install it beside under /usr/share/webapps and link it to the virtual servers making use of it. If virtual servers are used, this is more recommended since it is flexible and future oriented, so set the vhosts useflag. When the vhost useflag is set, then emerge dokuwiki.
<host> can be localhost or any other name of a host used.
cp local.php.dist local.php and do the modifications there.
Verify that users.auth.php has write permission, since this is to register users.
To create additional pages just create a link in the top page to the new page. Then click on the link and dokuwiki ask you to edit the newly created page.
Inside those two directories, other subdirectories can be created. This will be namespaces, that hold sub-dokuwikies. To make a link to them just use <namespace>:<pagename>.
When manually created such directories (make sure that have the same access rights and ownership) or when page got moved manually to such subpages, delete all files in /var/www/localhost/htdocs/dokuwiki/data/attic and in /var/www/localhost/htdocs/dokuwiki/data/metadata.
Additionally the links to pictures must be updated inside every page.
Alternatively the web server (as apache) could be reconfigured to get rid of the doku.php characters in the link.
The default settings are quite open and lets everybody editing pages. ACL (Access Control Lists) are used to login users and prevent that everybody can edit the wiki.
$conf['useacl'] = 1; //Use Access Control Lists to restrict access?
Note a login button appears now on the wiki page.
The dokuwiki can send out the password via mail. To have this work, you have to verify that apache can send emails. Since apache probably runs as root, root need to be able to send emails.
After that you can register yourself directly.
Make sure the /var/www/localhost/htdocs/dokuwiki/lib/plugins directory can be written.


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The Golden Age of Science Fiction: "Encased in the Amber of Eternity," by Robert Frazier
Friday, August 2, 2019 Steven H Silver Comments 0 Comment
Cover by Vincent di Fate
Cover by Tim Mullins
The Rhysling Awards, named for Robert A. Heinlein's poet from The Green Hills of Earth, were established by the Science Fiction Poetry Association in 1978. Both the association and the award were founded by Suzette Haden Elgin. Each year, awards are given for Short Form poetry and Long Form poetry. The first three years of the award resulted in ties, with three poems tying in the first year, and two each tying in the second and third year.
Robert Frazier's poem "Encased in the Amber of Eternity" depicts a Pacific Northwest in the aftermath of a nuclear war that has depopulated the North American continent (and presumably most of the rest of the world). His imagery moves briskly from descriptions of various objects associated with lights and fire representing the falling missiles, to the bone-like remnants of human civilization, represented by Portland. The poem's narrator, who seems to be a survivalist type, has managed to come through the catastrophe and offers a glimpse of hope that he will be able to find other survivors to rebuilt some sort of civilization, or, even if it is only him, at least he is still around.
Frazier uses repetitive imagery, although not repetition of phrases to build a sense of the destruction and following desolation from the nuclear attacks. That repetition falls apart as the poem begins to look at the unknown future that will have to be rebuilt. The poem is short, but contains a fully realized setting, even if the story it relates is left open-ended.
"Encased in the Amber of Eternity" was the first of a series of related poems Frazier published between 1979 and 1981, which also included "Encased in the Amber of Death," "Encased in the Amber of Fate," and "Encased in the Amber of Time." The first three poems appeared in The Future at War series edited by Reginald Bretnor, notably in Thor's Hammer, The Spear of Mars, and Orion's Sword. After that series ended, the final poem appeared in A Spadeful of Spacetime, edited by Fred Saberhagen.
Frazier attended the Clarion Writers Workshop in 1980 and went on to attend the Sycamore Hill Writer's Workshop. In addition to publishing fiction and poetry, he has also worked as an oil painter and a graphic designer, working with Mark V. Zeising Books for a time designing their books.
Frazier's poem tied for the Rhysling Award for short poetry with Peter Payack's poem "The Migration of Darkness."
Steven H Silver is a sixteen-time Hugo Award nominee and was the publisher of the Hugo-nominated fanzine Argentus as well as the editor and publisher of ISFiC Press for 8 years. He has also edited books for DAW, NESFA Press, and ZNB. He began publishing short fiction in 2008 and his most recently published story is "Webinar: Web Sites" in The Tangled Web. His most recent anthology, Alternate Peace was published in June. Steven has chaired the first Midwest Construction, Windycon three times, and the SFWA Nebula Conference 6 times, as well as serving as the Event Coordinator for SFWA. He was programming chair for Chicon 2000 and Vice Chair of Chicon 7.
Encased in the Amber of Eternity, Rhysling Award, Robert Frazier, The Golden Age of Science Fiction
Goth Chick News: Feeling at Home at the Oddities and Curiosities Expo
The Definition of a Long Game: The Raven's Mark Trilogy by Ed McDonald

redpajama_set_name: RedPajamaCommonCrawl


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And they're bad for some parents, too.
And they're bad for some parents, too.
How I walked the path to being a 'good' man.
How I walked the path to being a 'good' man.
Were You One of the Cool Kids?
How a type A overachiever crossed the finish line with time to spare.
The One You Feed…How Does Bigotry Rise to the Surface?
What do recent incidents say about how this country values women, the disabled, people of color, the LGBTQ community?
My antidepressants claim denied, I decided that the company needed to do better.
I didn't want to reach the level of depression I reached in 2006, so I asked for help.
I didn't want to reach the level of depression I reached in 2006, so I asked for help.


Check out these crazy shoes!
OK, I've been coming to London for many years now. And I miss Shelley's genius shoe stores! But this exhibit caught my eye–a carousel with some nutty designs including a shoe with a teapot heel, one with a unicorn toe and one lucite wedge (which you know I favor) with Cinderella inside. Sadly, none of them were available in petite size 13….
If burping is an art, then my dad is Picasso! A sneak peak at Art Basel Miami!
Thrilled to be a part of this line-up at Miami's Art Basel. Check the first artist, David Balula. I have got to see this fella! This is opening night's private event for bigwigs, but my outer space will be free and open to the public from 8-10PM Wednesday night. Please stop by. Then I'll dj at Pat Field's pop-up shop Thursday evening….
EXCITED TO ANNOUNCE MY 1ST EVER RUN AT LONDON'S SOHO THEATRE: FEB 13-25!


text:
Q: Upgrade to 12.04 LTS from 11.10 I initiated an upgrade to 12.04 from 11.10.  The upgrade manager had completed package download and installation but was killed before the cleanup phase started.  Ubuntu 12.04 is now loaded but occassional errors exist.  Should I do a reinstall from scratch or is there a way to reactivate the update manager to properly complete the installation?
Thanks,
...tom

A: Tom, you could also make sure everything finished installing.. Does running
sudo apt-get -f install

cause anything to happen? Are you able to install stuff now? You may also try removing and re-installing the ubuntu-desktop meta-package and see if everything is installed.
sudo apt-get remove ubuntu-desktop && sudo apt-get install ubuntu-desktop

Still, without knowing what these "errors" you speak of are, nor the state of your apt or machine it's hard to know what else to recommend for you outside of a fresh install.

A: The missed cleanup phase shouldn't cause any errors but, just to be safe, you can run
sudo apt-get autoremove

which will uninstall unneeded packages. This is probably most of what the cleanup phase was about to do before it exited.
If your problem persists, you may want to consider a full reinstall. Even if the upgrade had fully completed, people tend to report that 'clean installs' are faster and more stable than upgrades. I've personally never had a clean install go wrong, nor an upgrade go perfectly right, although many people claim it works fine for them.

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text:
Herbert Newman
FAIA
hnewman@newmanarchitects.com
Founder of Newman, Herb has guided a collaborative process of innovative inquiry and design in master planning, urban design, and architecture within the firm and the profession for more than 50 years. His contributions and dedication to the city of New Haven, CT, helped to redefine the it in a post-industrial era, and he remains active with selective projects in the New Haven office. Contributions to New Haven include the restored and expanded City Hall, award-winning restoration of Union Station, urban renewal projects such as Chapel Square Mall, Science Park and the Arts Center District, as well as numerous projects at Yale University
He began his career as an architectural designer with I.M. Pei and Partners in New York, working on international projects including Place Ville Marie in Montreal, Canada. He established the firm in New Haven in 1964, and began teaching at the Yale School of Architecture as a design critic. With Charles Moore and Kent Bloomer, he initiated the Yale School of Architecture Building Project, a cornerstone of the graduate architecture program. He continues to serve as a design critic and project coordinator.
Herb's leadership and design accomplishments have been widely acknowledged. He is a Fellow of the American Institute of Architects; he earned the AIA's Thomas Jefferson Award for Public Architecture, as well as five national AIA awards and more than 20 Connecticut AIA awards. He is a recipient of the Arts Council of Greater New Haven's Newton Schenk III Award for Lifetime Achievement in and Contribution to the Arts, recognizing his broad achievements in architecture. He has authored numerous articles and has served as a Visiting Critic, Juror, and Lecturer at Carnegie Mellon University, Harvard University, Columbia University, and the University of Tennessee.
M.Arch, Yale University; BA, Brown University
West Side Presbyterian Church
Ridgewood, NJ
Slover Library
Kykuit & Pocantico Conference Center
Rockefeller Brothers Fund


text:
IABM Index shows industry in flux
Should broadcasters continue to invest in linear, or focus instead on online? By Lorenzo Zanni.
The IABM has been conducting a biannual End-User Survey for some time now in order to gauge market sentiment and future trends.
This year, IABM introduced a companion piece of research – the newly published End-User Index – to look at the actual performance of broadcast and media organisations.
Lorenzo Zanni
Read together they provide a unique quantitative and qualitative overview of the end-user business - where it is now and where it's heading.
On the surface the End-User Index makes positive reading: overall revenues for broadcast and media companies grew by 9% between 2015 and 2016 (at constant exchange rates).
Put that alongside the findings of the April 2017 End-User Survey, where 74% of respondents were either quite or very positive in their outlook for the next three years, and we see a healthy, optimistic industry.
Looking behind the headline numbers though shows an industry that's also in flux – while revenues were up by 10% for media networks and 8% for pay-TV operators, only the latter are growing their profits – by 9% - while media networks' profits actually fell by 9%.
IBC2017 The IABM Breakfast: Technology and business transformation
Since media networks account for 75% of the market, this gives an aggregate decline in profits of 7% between 2015 and 2016.
So what's going on? IABM calculated all the companies' profit margins and divided them into groups according to their profit margin. Accordingly, 7% of companies are in loss, 20% have an operating profit margin that ranges 0-10%, 51% with a margin of 11-30%, and 22% with a margin greater than 30%.
An analysis of individual companies' profit margins shows that most new media operators are either in the loss-making or the 0-10% groups. This indicates that online delivery of content is based on a considerably smaller-margin business model than traditional broadcasting.
Since its advent in the first decade of the 2000s, OTT has changed the economics of content delivery; the new online video providers' business models are radically different from the "one-to-many" distribution of traditional broadcasting. The "one-to-one" model advocated by OTT providers is based on a more personal relationship with viewers, who can watch content on-demand whenever (and wherever) they like. This relationship is made possible by a fundamentally different technology infrastructure which allows for more flexibility and dynamism at the expense of the higher margins of traditional one-to-many broadcasting.
Competition from online media outlets such as Netflix, Hulu and Amazon has triggered a process of revenue diversification at traditional broadcasters. This diversification to include more online activities may be behind the profitability erosion highlighted by IABM figures. The media business is still healthy from a financial perspective – 93% of companies were in profit – but delivery is moving online, explaining the 7% decline in profits.
"Online delivery of content is based on a considerably smaller-margin business model than traditional broadcasting" - Lorenzo Zanni
This process not only involves the launch of new media offerings to complement existing linear broadcasting activities, but also the increased collaboration with social media platforms to reach younger audiences. For example, both CBS and Scripps Networks, two major US media networks, have publicly stated that they are partnering or considering partnerships with social media operators.
Scripps Networks Chief Executive Kenneth Wayne Lowe says: "How can we partner, how can we go beyond our core audiences to younger audiences that are not necessarily on linear television?
"And the real way to do it is to partner with Snapchat, with Facebook, on and on and on. And we think it will pay off in the long term. And I think sometimes we just don't get the credit for some of this expanding beyond the core linear television business, because it doesn't show immediate payoff on the bottom line. It's not about the money, it's about the amount. Everything we do and you can call it early stage experimentation or partnerships, is always with the point of view that this eventually is going to be a profit centre for us."
While broadcasters are launching new media offerings, what they want from suppliers is technology that makes their online operations more efficient and thus, profitable.
In the meantime, some broadcasting organisations may continue to prioritise their traditional offerings.
In fact, according to Belden Chief Executive John Stroup, some broadcasters are investing much more in their linear broadcasting businesses than their online offerings because the former still makes them more money:
He says: "Our traditional linear playout continues to grow. And I think that's because broadcasters recognise that although OTT is important it's still a relatively small percentage of their revenues and a very small percentage of their advertising. Therefore, making investments in their linear playout is important."
Broadcasters that continue to invest in linear broadcasting activities may be playing a dangerous game by prioritising short-term benefits over long-term success; it is clear that audiences are shifting to online platforms.
The erosion of profits highlighted by the IABM End-User Index data may be inevitable; traditional broadcast organisations need to continue to make their operations increasingly efficient to allow for a smooth transition to the new business models of online content delivery – moving from reliance on broadcasting dollars to harvesting digital pennies.
Lorenzo Zanni is IABM Research Analyst
IABM
HBO Europe content chief Antony Root to retire
HBO Max's European content chief Antony Root is to retire from his role at Warner Bros. Discovery at the end of March 2023.
Investigation launched into appointment process of BBC chairman
The process of appointing BBC chairman Richard Sharp is to be investigated following reports he helped Boris Johnson secure a loan.
Reed Hastings steps down as Netflix CEO
Reed Hastings is stepping down from his role as co-chief executive of Netflix.
More Thought leadership
Sustainability and delivering impeccable experiences are not mutually exclusive
The world's largest video streaming platforms alone account for a few billion users globally. Live video is demanding far more bits per second than any other type of internet usage. In 2019, Cisco estimated that video would make up at least 80% of the 4.8 zetabytes of data being delivered ...
Comment: time to Rise and shine
As Rise 2021 draws to a close, Kat Savage writes her fourth article for IBC365 and reflects on what being a part of the mentoring programme has meant for her and the progress she has made over the past six months.
Q&A: Maintaining engagement in an era of infinite choice
2022-01-26T16:04:00ZBrought to you by Friends MTS
Producing and protecting exclusive content is crucial to securing future revenues, says John Ward, Executive Vice-President Americas, Friend MTS


text:
Board of Trustees elects two Jesuits as new members
Alexa Jurado, News reporter|December 8, 2018
Two Jesuits were elected to Marquette University's Board of Trustees at a Dec. 7 meeting. Rev. Brian Linnane, S.J. and Rev. Michael Rozier, S.J. are the new members. Five to eight members of the board must be Jesuits.
Marquette trustees serve three-year terms and have the chance for re-election to serve for a maximum of 12 years. The trustees elect new members.
These trustees are volunteers and are not compensated for their work. The Board of Trustees is the principal governing authority for the university, and is made up of 25-40 members. They ensure the mission of Marquette University is maintained and university leaders plan and accomplish goals. They also establish policies and hire the university president.
Linnane has served as president of Loyola University Maryland since 2005. He formerly worked as assistant dean and associate professor of religious studies at the College of the Holy Cross in Worcester, Massachusetts. He entered the Society of Jesus in 1977 and was ordained to the Roman Catholic priesthood in 1986.
Rozier is an assistant professor of health management and policy at St. Louis University with a secondary appointment in the Albert Gnaegi Center for Health Care Ethics. He formerly served as an ethics fellow with the World Health Organization and was an instructor at St. Louis University. Rozier also serves on the board of directors for SSM Health Corporation and Loyola Academy in St. Louis. He entered the Society of Jesus in 2003 and was ordained as a priest in 2014.
Tags: Board of Trustees, December, Jesuits, Reverend Brian Linnane, Reverend Michael Rozier
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Down a quiet street on the western side of Ewing Twp, close to posh country club, D& R towpath, and a commuters delight to nearby Septa Train Station to Phila and major roads. Paver drive and winding walkway welcomes you to a traditional two story colonial as you are drawn into the living room, lightfilled by bay window, and door to screen porch to enjoy beautiful fall breeze. The beamed ceiling dining room offers plenty of space for quiet entertaining or larger family celebrations. Fully equipped kitchen, with lots of counter space for food prep, and back door to pretty backyard English gardens, low voltage lighting and bluestone walkways, highlighted in this years Garden tour. Upstairs three corner bedrooms accessed from loft at the top of the stairs. One car garage, Central air and more.


text:
A Chave simples masculino do Torneio de Roland Garros de 2018 teve Rafael Nadal como defensor do título. O espanhol conquistou seu 11º título no torneio ao derrotar o austríaco Dominic Thiem na decisão, por 6–4, 6–3, 6–2.
A cerimônia de premiação contou com a presença de Ken Rosewall, primeiro campeão do Torneio de Roland Garros na Era Aberta.

Cabeças-de-chave

  Rafael Nadal (Campeão)
  Alexander Zverev ''(Quartas-de-final)  Marin Čilić ''(Quartas-de-final)
  Grigor Dimitrov ''(Terceira Rodada)  Juan Martín del Potro (Semifinais)  Kevin Anderson ''(Quarta Rodada)
  Dominic Thiem (Final)
  David Goffin ''(Quarta Rodada)  John Isner ''(Quarta Rodada)
  Pablo Carreño Busta ''(Terceira Rodada)  Diego Schwartzman ''(Quartas-de-final)
  Sam Querrey (Segunda Rodada)
  Roberto Bautista Agut (Terceira Rodada)
  Jack Sock (Primeira Rodada)
  Lucas Pouille (Terceira Rodada)
  Kyle Edmund (Terceira Rodada)

<ol start="17">
  Tomáš Berdych (Primeira Rodada)
  Fabio Fognini (Quarta Rodada)
  Kei Nishikori (Quarta Rodada)
  Novak Djokovic ''(Quartas-de-final)''
  Nick Kyrgios (Desistência)
  Philipp Kohlschreiber (Primeira Rodada)
  Stan Wawrinka (Primeira Rodada)
  Denis Shapovalov (Segunda Rodada)
  Adrian Mannarino (Primeira Rodada)
  Damir Džumhur (Terceira Rodada)
  Richard Gasquet (Terceira Rodada)
  Feliciano López (Primeira Rodada)
  Gilles Müller (Primeira Rodada)
  Fernando Verdasco (Quarta Rodada)
  Albert Ramos Viñolas (Terceira Rodada)
  Gaël Monfils (Terceira Rodada)

Finais

Metade Superior

Seção 1

Seção 2

Seção 3

Seção 4

Metade Abaixo

Seção 5

Seção 6

Seção 7

Seção 8

Ligações externas

S
Torneio de Roland Garros - Simples masculino

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Babcock's Grove was incorporated as Lombard in 1869. Learn about interesting local events throughout the past 150 years.
Sarah Richardt, Executive Director of the Lombard Historical Society will regale you with stories about the people and buildings in old Lombard.
$3 suggested donation; free for LHS members.


Hampton Pool Company has built its reputation on developing long-term relationships and delivering outstanding customer service for the past 20 years. As pool and spa professionals, we provide comfort and relaxation. You will arrive home to find a swimming pool that is clean, clear, and maybe even warmed up a little…if you want. We create a hassle-free environment and offer our clients the peace of mind that they'll never have to worry about their pool or spa during the too-short time they're out at their home.
When you sign up for our service program, you will be dealing directly with one of our two owners. While you can always reach us on our cell phones or at 537-POOL, many of our clients prefer to communicate through email or text, which we love. After hours, our phone system forwards all voice-mails to us by email, so you can be sure that you will always be able to reach us in the event of an emergency.
We value communication as a most important quality. Returning phone calls quickly and responding to any issue as soon as it may arise are cornerstones of the Hampton Pool Company philosophy. We are open 7 days a week, so our industry certified technicians and GPS tracked vehicles are ready to react to any demand immediately.
Peter has been a partner at Hampton Pool Company since 2007. As Service Manager, he utilizes his strong communication skills to build loyal, long-term relationships to ensure that quality and service exceed customer expectations. A transplant from Buffalo, Pete now resides in Wainscott with his wife Sally and son Leonardo. If they aren't biking around town or relaxing at Beach Lane, they can be found braving the crowds at Breadzilla or Goldberg's.
Mike was raised at the other end of Long Island in Garden City, spending summers on the East End with his family. After graduating with a degree in Finance and Music from Boston College in 2004, he got a summer job cleaning pools in the Hamptons…and never left. When Mike's not in the office, he's likely either at home in Wainscott playing the guitar, or traveling somewhere to see someone else do it.


text:
800 reserves Punjab police training institutions to placed for Azadi March
LAHORE: More than 800 reserves from the police training institutions of Punjab have been placed at the disposal of 36 districts to preempt any law and order situation in view of the 'Azadi March' announced by the Jamiat Ulema-i-Islam-Fazl (JUI-F).
The Rawalpindi district received highest number of reserves [120], followed by Attock (80), Lahore (50), Rahim Yar Khan (18) and Multan (16). The district police officers (DPOs) have been directed to use them for reinforcement besides making deployment of their respective district force in case of any emergency situation.
The police reserves have been dispatched from the five police training centres/ schools including the Punjab Constabulary Farooqabad, Police College Sihala, Police Training College Chuhng and police training institutions of Farooqabad, Rawalpindi, Sargodha and Multan.
"The heads of the above-mentioned institutions have been directed to spare 503 reserves to put them to the disposal of the districts," an official privy to the development said. He further said the decision was taken in a high-level meeting held at Central Police Office (CPO) a couple of days back.
An official letter to the effect was also issued by the CPO to all heads of the institutions with directions that the reserve force must reach the districts on Wednesday.
"The force shall be spared on Oct 23, for onward transportation to the borrowing districts of the province," reads the letter.
It further stated that the allocated force shall bring with them seasonal bedding and proper uniform. They were directed to carry with them their original CNICs besides official identity cards, the letter says.


Here are a few online sites that post information about paying gigs for freelance writers.
1.allfreelancewriting.com: Browse by category or specific freelance markets.
2.duotrope.com: Detailed descriptions and market database for the perfect place to submit what you write. Lots of short story markets as well.
3. freelancewritinggigs.com: daily postings of the latest freelance opportunities.
4. fundsforwriters.com: Information about grants, contests and other ways to get paid as a writer.
Here are the links to some great Literary Agent resources to learn all about publishing, what specific agents are looking for, and answers to questions regarding many of the aspects of writing and publishing.
1. adventuresinagentland.blogspot.com is run by Bradford Literary Agent Natalie Lakosil has lots of information on queries and submissions.
2. aaronline.org is the official website of the Association of Authors' Representatives and lists reputable representatives who follow a specific code of ethics.
3.jetreidliterary.blogspot.com offers advice from Janet Reid of Fine Print Literary Management.
4.redsofaliterary.com offers up lots of submission tips as well as general advice for writers thanks to it's author Dawn Frederick.
As scary as they are up close, we all love sharks from a distance. Books about these ancient warriors of the deep are among the most popular in libraries and bookstores. Now that summer is here, your child can have some fun making sharks "come to life" with this simple craft.
SHARK PUPPET: All that is needed to make these undersea beasts are: business envelopes, Sharpie marker, transparent tape, scissors (I like to use pinking shears since they make the shark mouth look like teeth). Follow the photos and in minutes, you'll be launching your own Shark Attack.
Directions: Seal the envelope shut. Cut on the lines indicated in the photo on the left.
Use the triangle for the dorsal fin, draw gills and eyes on both sides of the envelope. Put your hand through the center and VOILA!
MarthaSpeaks.com is a great website for kids of all ages who enjoy video games, puzzles and interactive computer activities. You can download and play a variety of games listed by category. There are lots of new ones to choose from, and many of the old classics such as FROGGER, PAC MAN, and SONIC as well. There are even online jigsaw puzzles! Some of the games/activities coincide with the PBS series, other are just for fun.
Check it out. I'm sure you'll find something for every game lover in the house.
Last weekend I was fortunate to attend the NJSCBWI Conference in Princeton, NJ. Not only was it full of interesting and inspiring workshops and presentations, I also got to meet many of the best writers in the field of Children's Literature. Illustrator Dan Yaccarino spoke to us on Saturday with a message titled YES, and how when opportunity presents itself, don't think of how you won't be able to do something, but rather embrace the learning and say "Yes…I can do it". Kate DiCamillo gave the keynote address on Sunday and awed all of us with her eloquence and generosity.
There were also many excellent agents, editors, and writers who presented workshops, gave critiques and just made us writers feel good to be in their midst.
As writers we sometimes struggle with naming our characters. If you're like me, you want the character to be memorable and the name to stay with the reader after the book is finished. Think about all those characters who still stay with us and need no introduction: Scarlett, Ishmail, Templeton, Atticus, Huck, Katniss, Frodo, and so forth.
The next time you are looking for a name that goes beyond the ordinary, try this website: http://www.behindthename.com. It lists the history and origin of first names.
Which character name/s is your favorite? Do you have other ideas for coming up with names? I'd love to hear from you.
I just finished reading WONDER by R J Palacio and was absolutely stunned by the intelligence, honesty, hope, courage and "wonder" in its pages. This MG/YA book should be on every middle school reading list. At a time when there is so much negative press about bullying and peer pressure to conform, a story like this comes along and makes us all examine our selves to see what we stand for. This is a story I will be thinking about for a long time.


This role offers some flexibility for home working but would like the candidate to be located within a 30-mile radius to the offices in Stockport to be supported by the inhouse team.
The main role is to assist with the design, implementation and support to new and existing clients, of the Avaya Portfolio.
Server Edition Accreditation and experience is essential.
On Premise, Cloud and Hybrid Solution deployment.
Attractive Salary and package dependent upon experience.
Design, Implement, support and service Avaya IP-Office 500 and Server Edition delivering both cloud and on-premise, SBC, Contact Centre Applications and 3rdparty solution partners.
Provide Remote Access and on-site support to service a UK Client base, update the company CRM and regularly update tickets and report to the Ops Manager.
The candidate is also required to assist with pre-sales and design with the projects team, where necessary.
This role may require out of hours work completion on site and at ICA's offices.
Send us your up to date CV and cover letter by clicking 'Apply for this position' button below. Make sure you attach your CV and cover letter (only word docs and pdf's will be viewed) and a brief descritption detailing why you would like to work with ICA and why the role is perfect for you.
All applications are kept confidential. Only successful applicants will be contacted. Please no recruiters or phone calls.


text:
Diane DeCesare, CPA, MT
Shareholder and Chief Knowledge Officer
LinkedIN | Download VCard | Download Bio
Drexel University, BS
Villanova University, MT
Tax Warrior Profile
Effective January 1, 2022, Diane will serve as the firm's first Chief Knowledge Officer, responsible for the firm tax practice. Diane joined D&S in 1992, and became a shareholder in 1994. She has been practicing in the tax field for more than 30 years, has developed an extensive background in tax, business, accounting and financial planning for corporations, partnerships and individuals. She has also acquired substantial experience working with closely held businesses, handling issues concerning the business as well as issues specific to the owners.
In some of her recent engagements, she has represented buyers and sellers in business purchase and sales transactions, provided for the planning and facilitation of these transactions, and provided litigation support in various divorces and other cases.
In addition to her role as shareholder, Diane has directed the college recruiting and staffing efforts at D&S for more than 20 years, serves on the firm's Executive Committee and chairs its Compensation Committee.
Diane began her career in the Philadelphia office of Laventhol & Horwath as a Drexel University co-op student, where she worked in the areas of individual taxation, real estate taxation and personal financial planning. Later, she headed the tax department of a Delaware Valley financial services group consisting of thirty companies involved in such areas as banking, mortgage servicing, leasing and construction.
Diane received a Bachelor of Science degree in business administration from Drexel University, where she majored in accounting and graduated with highest honors, finishing first in her class. She later earned a Master of Taxation from the Villanova Law School Graduate Tax Program, also finishing first in her class. She also received the Elijah Watt Sells Certificate for her performance with high distinction on the Uniform Certified Public Accountant Examination. Diane is a member of both the American Institute of Certified Public Accountants and the Pennsylvania Institute of Certified Public Accountants (PICPA) as well as the Estate and Financial Planning Council of South Jersey. She is active in PICPA lobbying efforts to protect and grow the accounting profession. She is a member of the Board of Directors for Saints John Neumann & Maria Goretti Catholic High School in Philadelphia, and a member of the Employer Advisory Board of the Steinbright Career Development Center at Drexel University.
Diane resides in Marlton, New Jersey, with her husband, Mark, and their two children. Mark operates Diane's Italian Water Ices in Voorhees, New Jersey, a successful business started by the couple in 1994. Their water ice has been named "Best of South Jersey" by South Jersey Magazine several times, and has also been featured in the "Best Finds" section of The Philadelphia Inquirer.
Webinar - Cash Flow Impact of M&A - XPX Exit Planning Exchange - Recorded June 19, 2020
Listen to D&S Partner Diane DeCesare on WKYW News Radio discussing the taxability of the COVID-19 stimulus checks and unemployment insurance payments. - April 27, 2020
Who's Hiring? Drucker & Scaccetti - DrexelNOW, April 26, 2016
Adopt A Strategic Approach To Protect Your Wealth More Effectively
Tactical Tax Planning
The Tax Warriors protect your assets and chart your path to strong, sustainable growth with strategic business and personal financial consulting.
As part of our ongoing client service mission, The Tax Warriors post regular articles on subjects critical to the success and protection of our clients' financial interests.


text:
From all angles, the Tiguan S looks like an amalgamation of the full-size Touareg SUV and the Rabbit compact hatchback, with which the Tiguan shares a platform. Taking the best elements from each vehicle, the Tiguan is among the best-looking CUVs available.
Caption:Antuan GoodwinPhoto:CNET Networks
The almost full-width grille and swept-back headlamps make the Tiguan look wider than it is. Actually, the Tiguan is only slightly wider than the VW GTI.
Updated: July 29, 2009 Caption:Antuan GoodwinPhoto:CNET Networks
As tested, our Tiguan was a front-wheel-drive model. A 4Motion all-wheel-drive option is available, but for the environments in which the Tiguan usually finds itself, the standard drivetrain is sufficient.
The suspension does an impressive job of keeping the tall and top-heavy Tiguan flat on the twisting roads. When the road surface gets bumpy, the long travel and soft suspension tuning keep the driver isolated and comfortable.
Storage space in the rear is sufficient, but with the privacy shelf cutting into the space, there's not much more space than is present in the Rabbit. Removing the shelf and flattening the rear seats, however, opens up enough space to carry two bicycles with the front tires removed.
The 200 horsepower 2-liter TSFI engine is the Tiguan's crown jewel. The turbocharged and direct-injected powerplant supplies power that makes the small SUV feel like a hot hatchback. At low engine speeds, however, lag in the power delivery is evident.
As fantastic as the Tiguan's exterior and powertrain are, the interior is equally boring. Every surface is covered in the same black plastic that, while not visually offensive, feels out of place in such a sporty vehicle.
The Tiguan S lacks tech options, which is reflected by the simple, buttonless steering wheel.
The gauge cluster is attractive, with nice blue illumination at night, but the trip computer doesn't give the driver very much information. Stepping up the Tiguan SE or SEL will upgrade the trip computer to a more functional unit.
The Tiguan's six-speed automatic transmission features three forward modes: Normal, which is tuned for comfort; Sport which, raises the shift points to keep the turbo spinning; and Tiptronic, which allows the driver to control the shifting. Being a standard transmission, the shifts are a bit on the slow side, but a six-speed manual option is available.
Just aft of the electric parking brake switch is the Auto Hold button. The Auto Hold feature holds the brakes after the pedal is released, keeping the car stationary. When the gas pedal is depressed, the brakes release and the vehicle moves. We can see the feature being useful in hilly areas on models equipped with the six-speed manual, but with our automatic transmission, the feature was more annoying than useful. Fortunately, it's easily turned off.
The standard audio system is fairly simple and low tech. The single-disc CD player accepts MP3 CDs, but navigating the folder with the single-line display is cumbersome. There's an Aux-In hidden in the center console and AM/FM radio rounds out the available audio sources.
There are no available audio upgrades at this trim level, but stepping up to the SEL will replace the system with a 300 watt Dynaudio system.
The eight-speaker standard audio system sounds acceptable. High tones are slightly muddied and at high volumes, the sound is overwhelmed by distorted bass.
Photos: 2009 Volkswagen Tiguan S
Hands on with widescreen Android Auto in the 2020 Lexus RX


The Best family hotels in Europe for happy holidays.
Experience the most happy and joyful family holidays while staying at the most spectacular and family- friendly hotels, resorts and villas all over Europe.
Crete: Relax in the crystal-blue beaches of a Mediterranean island!
Crete has so many beaches that picking the best Crete beach is too hard for us but consider having an open-air seafront yoga session because it is a must when visiting Crete!
Crete has several outdoor activities from boat tours, scuba diving, snorkeling and water sports to water and amusement parks, tracking through impressive gorges and mountain climbing.
Crete offers endless opportunities for relaxation and serenity and the best way to experience it is to pay a visit at the several hotels and resorts that feature their own spa centres!
Personal consultation, special treatments and a huge variety of sessions, are the least you can expect when visiting a spa hotel or wellness resort in Crete.
Crete has a rich history that goes back to the 7th millennium BC, so there are many museums to visit and a lot sightseeing to do. The most famous site is Knossos Palace in Heraklion.
Cretan cuisine involves traditional and Mediterranean dishes enriched with locally produced olive oil, promising physical health and mental clarity.
As Crete has some of the oldest wine-producing areas, it is highly recommended to take part in a wine tour where you will taste some of the best collections of wine.
Taking a private luxury yacht tour in Crete will guide you to the most sought-after attractions and hidden natural beaches and gems of Crete!
Since Crete is a popular destination among families, most of the Cretan 5 star resorts have taken care of developing special facilities for children and thus offering you more relaxing vacations!
Peza Area is a major wine-production region in Heraklion of Crete as 70% of the local wine production comes from that area.
Keep in mind that the nudist areas of Elafonissos beach and Vrahakia (in Agioi Apostoloi) are also mainly visited by gay men.
If you are seeking for discreet gay/nudist beaches in Crete keep in mind that Akti Olountos, Peristeras and the beaches near Malia and Sarantari are some of the best options.
Near Agios Nikolaos city, you will find the beaches of Vai and Agia Fotia, which are the most popular gay friendly beaches of the area.
Crete gay beaches are found all around the coastal area, with some of the most beautiful and 'fun' ones located close to Chania.
The most popular red grape varieties which produce delicious wines, are Kotsifali, Mantilari, Liatiko, Tsardana, and the outstanding Romeiko.
The traditional beef stifado is one of the most popular dishes in Crete, made of meat cooked with whole, small and sweet onions. There is also an alteration made with rabbit, which is even more tasty!
The traditional salad of Crete, Ntakos, is one of the most tasteful & healthiest salads you can eat! It has tomatoes, feta cheese and olives laid on a barley rusk, and is served with pure olive oil.
The most popular Cretan dishes are made with lamb, chicken or rabbit. Make sure to try the amazing 'gamopilafo' (made with rice and lamb in the oven).
Don't get carried away with "raki"; this Cretan drink is very strong and you may see locals drinking it as naturally as water, but keep in mind they are used to it.
Crete rises as one of the top luxury destinations in Greece and the Mediterranean.
The Cretan Wineries you should know!


text:
Small interfering RNA screening for the small GTPase rab proteins identifies Rab5B as a major regulator of hepatitis B virus production
Jun Inoue, Masashi Ninomiya, Teruyuki Umetsu, Takuya Nakamura, Takayuki Kogure, Eiji Kakazu, Tomoaki Iwata, Satoshi Takai, Akitoshi Sano, Mitsunori Fukuda, Koichi Watashi, Masanori Isogawa, Yasuhito Tanaka, Tooru Shimosegawa, Mark A. McNiven, Atsushi Masamunea
大学病院・内科
医学系研究科・医科学専攻
IMPORTANCE HBV infection is a worldwide health problem, but the mechanisms of how HBV utilizes cellular machinery for its life cycle are poorly understood. In particular, it has been unclear how the viral components and virions are transported among the organelles. The HBV budding site has been reported to be the ER or MVB, but it has not been clearly determined. In this study, siRNA-based screening of Rab proteins using HBV-expressing cells showed that Rab5B, one of the Rab5 isoforms, has important roles in late steps of the HBV life cycle. Although Rab5 is known to work on early endosomes, this study showed that Rab5B plays a role in the transport of LHBs between the ER and MVB. Furthermore, it affects the transcription of LHBs. This is the first report on the mechanisms of HBV envelope protein transport among the organelles, and the results provide important insights into the therapeutic control of HBV infection.
Viruses are considered to use vesicular trafficking in infected cells, but the details of assembly/release pathways of hepatitis B virus (HBV) are still unknown. To identify key regulators of HBV production, we performed short interfering RNA (siRNA) screening for Rab proteins, which are considered to act as molecular switches in vesicular trafficking using HepG2.2.15 cells. Among 62 Rab proteins, the suppression of Rab5B most significantly increased HBV DNA in the culture supernatant. Surprisingly, 5 days after the transfection of Rab5B siRNA, HBV DNA in the supernatant was increased more than 30-fold, reflecting the increase of infectious HBV particles. Northern blotting showed that transcription of 2.4/2.1-kb mRNA coding envelope proteins containing large hepatitis B surface protein (LHBs) was increased. Analysis of hepatocyte nuclear factors (HNFs) showed that transcription of HNF4, which is known to enhance 2.4-kb mRNA transcription, was regulated by Rab5B. Also, it was revealed that LHBs had accumulated in the endoplasmic reticulum (ER) after Rab5B depletion but not in the multivesicular body (MVB), which is thought to be an organelle utilized for HBV envelope formation. Therefore, it was considered that Rab5B is required for the transport of LHBs from the ER to MVB. Immunofluorescent microscopy showed that HBs proteins, including LHBs, colocalized with HBc in the ER of Rab5B-depleted cells, suggesting that HBV envelopment occurs not only in the MVB but also in the ER. In conclusion, Rab5B is a key regulator of HBV production and could be a target of antiviral therapy.
論文番号
Journal of virology
https://doi.org/10.1128/JVI.00621-19
昆虫科学
ウイルス学
この成果は、次の持続可能な開発目標に貢献しています
10.1128/JVI.00621-19
「Small interfering RNA screening for the small GTPase rab proteins identifies Rab5B as a major regulator of hepatitis B virus production」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。
Hepatitis B virus Agriculture & Biology 100%
Monomeric GTP-Binding Proteins Medicine & Life Sciences 84%
small interfering RNA Agriculture & Biology 82%
guanosinetriphosphatase Agriculture & Biology 82%
Small Interfering RNA Medicine & Life Sciences 60%
screening Agriculture & Biology 50%
Multivesicular Bodies Medicine & Life Sciences 38%
Endoplasmic Reticulum Medicine & Life Sciences 31%
Inoue, J., Ninomiya, M., Umetsu, T., Nakamura, T., Kogure, T., Kakazu, E., Iwata, T., Takai, S., Sano, A., Fukuda, M., Watashi, K., Isogawa, M., Tanaka, Y., Shimosegawa, T., McNiven, M. A., & Masamunea, A. (2019). Small interfering RNA screening for the small GTPase rab proteins identifies Rab5B as a major regulator of hepatitis B virus production. Journal of virology, 93(15), [e00621-19]. https://doi.org/10.1128/JVI.00621-19
Small interfering RNA screening for the small GTPase rab proteins identifies Rab5B as a major regulator of hepatitis B virus production. / Inoue, Jun; Ninomiya, Masashi; Umetsu, Teruyuki; Nakamura, Takuya; Kogure, Takayuki; Kakazu, Eiji; Iwata, Tomoaki; Takai, Satoshi; Sano, Akitoshi; Fukuda, Mitsunori; Watashi, Koichi; Isogawa, Masanori; Tanaka, Yasuhito; Shimosegawa, Tooru; McNiven, Mark A.; Masamunea, Atsushi.
In: Journal of virology, Vol. 93, No. 15, e00621-19, 2019.
Inoue, J, Ninomiya, M, Umetsu, T, Nakamura, T, Kogure, T, Kakazu, E, Iwata, T, Takai, S, Sano, A, Fukuda, M, Watashi, K, Isogawa, M, Tanaka, Y, Shimosegawa, T, McNiven, MA & Masamunea, A 2019, 'Small interfering RNA screening for the small GTPase rab proteins identifies Rab5B as a major regulator of hepatitis B virus production', Journal of virology, vol. 93, no. 15, e00621-19. https://doi.org/10.1128/JVI.00621-19
Inoue J, Ninomiya M, Umetsu T, Nakamura T, Kogure T, Kakazu E et al. Small interfering RNA screening for the small GTPase rab proteins identifies Rab5B as a major regulator of hepatitis B virus production. Journal of virology. 2019;93(15). e00621-19. https://doi.org/10.1128/JVI.00621-19
Inoue, Jun ; Ninomiya, Masashi ; Umetsu, Teruyuki ; Nakamura, Takuya ; Kogure, Takayuki ; Kakazu, Eiji ; Iwata, Tomoaki ; Takai, Satoshi ; Sano, Akitoshi ; Fukuda, Mitsunori ; Watashi, Koichi ; Isogawa, Masanori ; Tanaka, Yasuhito ; Shimosegawa, Tooru ; McNiven, Mark A. ; Masamunea, Atsushi. / Small interfering RNA screening for the small GTPase rab proteins identifies Rab5B as a major regulator of hepatitis B virus production. In: Journal of virology. 2019 ; Vol. 93, No. 15.
@article{59009891d0a54e08a5a151fb516e0b39,
title = "Small interfering RNA screening for the small GTPase rab proteins identifies Rab5B as a major regulator of hepatitis B virus production",
abstract = "IMPORTANCE HBV infection is a worldwide health problem, but the mechanisms of how HBV utilizes cellular machinery for its life cycle are poorly understood. In particular, it has been unclear how the viral components and virions are transported among the organelles. The HBV budding site has been reported to be the ER or MVB, but it has not been clearly determined. In this study, siRNA-based screening of Rab proteins using HBV-expressing cells showed that Rab5B, one of the Rab5 isoforms, has important roles in late steps of the HBV life cycle. Although Rab5 is known to work on early endosomes, this study showed that Rab5B plays a role in the transport of LHBs between the ER and MVB. Furthermore, it affects the transcription of LHBs. This is the first report on the mechanisms of HBV envelope protein transport among the organelles, and the results provide important insights into the therapeutic control of HBV infection.Viruses are considered to use vesicular trafficking in infected cells, but the details of assembly/release pathways of hepatitis B virus (HBV) are still unknown. To identify key regulators of HBV production, we performed short interfering RNA (siRNA) screening for Rab proteins, which are considered to act as molecular switches in vesicular trafficking using HepG2.2.15 cells. Among 62 Rab proteins, the suppression of Rab5B most significantly increased HBV DNA in the culture supernatant. Surprisingly, 5 days after the transfection of Rab5B siRNA, HBV DNA in the supernatant was increased more than 30-fold, reflecting the increase of infectious HBV particles. Northern blotting showed that transcription of 2.4/2.1-kb mRNA coding envelope proteins containing large hepatitis B surface protein (LHBs) was increased. Analysis of hepatocyte nuclear factors (HNFs) showed that transcription of HNF4, which is known to enhance 2.4-kb mRNA transcription, was regulated by Rab5B. Also, it was revealed that LHBs had accumulated in the endoplasmic reticulum (ER) after Rab5B depletion but not in the multivesicular body (MVB), which is thought to be an organelle utilized for HBV envelope formation. Therefore, it was considered that Rab5B is required for the transport of LHBs from the ER to MVB. Immunofluorescent microscopy showed that HBs proteins, including LHBs, colocalized with HBc in the ER of Rab5B-depleted cells, suggesting that HBV envelopment occurs not only in the MVB but also in the ER. In conclusion, Rab5B is a key regulator of HBV production and could be a target of antiviral therapy.",
keywords = "Endoplasmic reticulum, Envelope, Hepatitis B virus, Hepatocyte nuclear factor, Multivesicular body, Rab5B",
author = "Jun Inoue and Masashi Ninomiya and Teruyuki Umetsu and Takuya Nakamura and Takayuki Kogure and Eiji Kakazu and Tomoaki Iwata and Satoshi Takai and Akitoshi Sano and Mitsunori Fukuda and Koichi Watashi and Masanori Isogawa and Yasuhito Tanaka and Tooru Shimosegawa and McNiven, {Mark A.} and Atsushi Masamunea",
note = "Funding Information: We thank the Biomedical Research Unit of Tohoku University Hospital and the Biomedical Research Core of the Tohoku University Graduate School of Medicine for technical support. This study was supported by Grants-in-Aid from the Japan Society for the Promotion of Science (26893011 and 15K08981) to J.I. and the Japan Agency for Medical Research and Development (JP18fk0310101h0002) to Y.T. Funding Information: This study was supported by Grants-in-Aid from the Japan Society for the Promotion of Science (26893011 and 15K08981) to J.I. and the Japan Agency for Medical Research and Development (JP18fk0310101h0002) to Y.T. Publisher Copyright: Copyright {\textcopyright} 2019 American Society for Microbiology. All Rights Reserved.",
doi = "10.1128/JVI.00621-19",
journal = "Journal of Virology",
publisher = "American Society for Microbiology",
T1 - Small interfering RNA screening for the small GTPase rab proteins identifies Rab5B as a major regulator of hepatitis B virus production
AU - Inoue, Jun
AU - Ninomiya, Masashi
AU - Umetsu, Teruyuki
AU - Nakamura, Takuya
AU - Kogure, Takayuki
AU - Kakazu, Eiji
AU - Iwata, Tomoaki
AU - Takai, Satoshi
AU - Sano, Akitoshi
AU - Fukuda, Mitsunori
AU - Watashi, Koichi
AU - Isogawa, Masanori
AU - Tanaka, Yasuhito
AU - Shimosegawa, Tooru
AU - McNiven, Mark A.
AU - Masamunea, Atsushi
N1 - Funding Information: We thank the Biomedical Research Unit of Tohoku University Hospital and the Biomedical Research Core of the Tohoku University Graduate School of Medicine for technical support. This study was supported by Grants-in-Aid from the Japan Society for the Promotion of Science (26893011 and 15K08981) to J.I. and the Japan Agency for Medical Research and Development (JP18fk0310101h0002) to Y.T. Funding Information: This study was supported by Grants-in-Aid from the Japan Society for the Promotion of Science (26893011 and 15K08981) to J.I. and the Japan Agency for Medical Research and Development (JP18fk0310101h0002) to Y.T. Publisher Copyright: Copyright © 2019 American Society for Microbiology. All Rights Reserved.
N2 - IMPORTANCE HBV infection is a worldwide health problem, but the mechanisms of how HBV utilizes cellular machinery for its life cycle are poorly understood. In particular, it has been unclear how the viral components and virions are transported among the organelles. The HBV budding site has been reported to be the ER or MVB, but it has not been clearly determined. In this study, siRNA-based screening of Rab proteins using HBV-expressing cells showed that Rab5B, one of the Rab5 isoforms, has important roles in late steps of the HBV life cycle. Although Rab5 is known to work on early endosomes, this study showed that Rab5B plays a role in the transport of LHBs between the ER and MVB. Furthermore, it affects the transcription of LHBs. This is the first report on the mechanisms of HBV envelope protein transport among the organelles, and the results provide important insights into the therapeutic control of HBV infection.Viruses are considered to use vesicular trafficking in infected cells, but the details of assembly/release pathways of hepatitis B virus (HBV) are still unknown. To identify key regulators of HBV production, we performed short interfering RNA (siRNA) screening for Rab proteins, which are considered to act as molecular switches in vesicular trafficking using HepG2.2.15 cells. Among 62 Rab proteins, the suppression of Rab5B most significantly increased HBV DNA in the culture supernatant. Surprisingly, 5 days after the transfection of Rab5B siRNA, HBV DNA in the supernatant was increased more than 30-fold, reflecting the increase of infectious HBV particles. Northern blotting showed that transcription of 2.4/2.1-kb mRNA coding envelope proteins containing large hepatitis B surface protein (LHBs) was increased. Analysis of hepatocyte nuclear factors (HNFs) showed that transcription of HNF4, which is known to enhance 2.4-kb mRNA transcription, was regulated by Rab5B. Also, it was revealed that LHBs had accumulated in the endoplasmic reticulum (ER) after Rab5B depletion but not in the multivesicular body (MVB), which is thought to be an organelle utilized for HBV envelope formation. Therefore, it was considered that Rab5B is required for the transport of LHBs from the ER to MVB. Immunofluorescent microscopy showed that HBs proteins, including LHBs, colocalized with HBc in the ER of Rab5B-depleted cells, suggesting that HBV envelopment occurs not only in the MVB but also in the ER. In conclusion, Rab5B is a key regulator of HBV production and could be a target of antiviral therapy.
AB - IMPORTANCE HBV infection is a worldwide health problem, but the mechanisms of how HBV utilizes cellular machinery for its life cycle are poorly understood. In particular, it has been unclear how the viral components and virions are transported among the organelles. The HBV budding site has been reported to be the ER or MVB, but it has not been clearly determined. In this study, siRNA-based screening of Rab proteins using HBV-expressing cells showed that Rab5B, one of the Rab5 isoforms, has important roles in late steps of the HBV life cycle. Although Rab5 is known to work on early endosomes, this study showed that Rab5B plays a role in the transport of LHBs between the ER and MVB. Furthermore, it affects the transcription of LHBs. This is the first report on the mechanisms of HBV envelope protein transport among the organelles, and the results provide important insights into the therapeutic control of HBV infection.Viruses are considered to use vesicular trafficking in infected cells, but the details of assembly/release pathways of hepatitis B virus (HBV) are still unknown. To identify key regulators of HBV production, we performed short interfering RNA (siRNA) screening for Rab proteins, which are considered to act as molecular switches in vesicular trafficking using HepG2.2.15 cells. Among 62 Rab proteins, the suppression of Rab5B most significantly increased HBV DNA in the culture supernatant. Surprisingly, 5 days after the transfection of Rab5B siRNA, HBV DNA in the supernatant was increased more than 30-fold, reflecting the increase of infectious HBV particles. Northern blotting showed that transcription of 2.4/2.1-kb mRNA coding envelope proteins containing large hepatitis B surface protein (LHBs) was increased. Analysis of hepatocyte nuclear factors (HNFs) showed that transcription of HNF4, which is known to enhance 2.4-kb mRNA transcription, was regulated by Rab5B. Also, it was revealed that LHBs had accumulated in the endoplasmic reticulum (ER) after Rab5B depletion but not in the multivesicular body (MVB), which is thought to be an organelle utilized for HBV envelope formation. Therefore, it was considered that Rab5B is required for the transport of LHBs from the ER to MVB. Immunofluorescent microscopy showed that HBs proteins, including LHBs, colocalized with HBc in the ER of Rab5B-depleted cells, suggesting that HBV envelopment occurs not only in the MVB but also in the ER. In conclusion, Rab5B is a key regulator of HBV production and could be a target of antiviral therapy.
KW - Endoplasmic reticulum
KW - Envelope
KW - Hepatitis B virus
KW - Hepatocyte nuclear factor
KW - Multivesicular body
KW - Rab5B
U2 - 10.1128/JVI.00621-19
DO - 10.1128/JVI.00621-19
JO - Journal of Virology
JF - Journal of Virology
M1 - e00621-19


text:
Shelling spreads misery in Kashmir, caught between two nuclear rivals
A Pakistani Kashmiri woman stands amid debris of her home that reportedly was destroyed by cross border shelling from Indian troops, in Neelum Valley, situated at the Line of Control in Pakistani Kashmir.
(M.D. Mughal)/AP)
By Showkat Nanda
URI, India —
A live mortar shell landed with a thud in the living room, though it did not explode.
Soraya Begum, a 48-year-old widow living in a hilly area along the Indian-Pakistani border, scooped up her 8-year-old son. She ran to a neighbor's house as two more shells fell on her property, exploding in the dirt "like a mini-volcano" and forming 3-foot craters.
"It takes a few seconds for the shells to reach us once they are fired," said Begum, who raises cattle for a living. "If you are lucky you manage to save yourself. Otherwise you die."
Nearly 40 mortar shells fired by Pakistani troops fell in Begum's village of Batgran on the afternoon of Oct. 13. The shelling was part of what residents and local officials describe as one of the most intense bursts of violence by the rival Pakistani and Indian militaries in years.
Shelling along the Line of Control — the de facto border dividing India and Pakistan in the disputed Himalayan territory of Kashmir — has grown markedly since August, when New Delhi revoked Kashmir's limited autonomy and ended its status as a state, bringing it under the direct control of the Indian government.
The move was part of Indian Prime Minister Narendra Modi's aggressive Hindu nationalist project, whose goals include taming the long-running separatist insurgency in the Indian-held portion of Kashmir, which had been the country's only Muslim-majority state. India has blocked internet service across the territory for more than four months and detained all of Kashmir's major political leaders.
Back Story: An increasingly popular authoritarian tool: Shutting down the internet
For civilians in Myanmar's Rakhine state — who have survived army-led massacres, violence by ethnic militias, restrictions on humanitarian aid and the forced displacement of hundreds of thousands of neighbors — life just got more difficult.
Pakistan administers another portion of Kashmir; the rival nations have fought three wars over the Himalayan region since gaining independence from Britain in 1947.
India and Pakistan have observed a cease-fire since 2003 along the 460-mile boundary, but the two armies routinely violate the truce by firing into the other's territory, sometimes into inhabited villages.
India's Defense Ministry said last month that it had recorded more than 950 cease-fire violations by Pakistani forces along the Line of Control since August, far more than in any three-month period since 2003. At least four soldiers and two civilians have been killed.
Pakistani officials say that 35 people, including eight security personnel, died when Indian forces fired weapons into the Pakistani-administered part of Kashmir.
In India, the shelling has been heaviest in Uri, an area that includes numerous mountain villages where, according to police, this year there have been 51 major Pakistani cease-fire violations — defined as ones where mortars and heavy artillery are employed — by far the most in any year since 2003. Of those cease-fire violations, 37 have come since the Indian home minister, Amit Shah, announced the revocation of Kashmir's statehood on Aug. 5.
Fear and tension mount in Kashmir's largest city amid lockdown
In Srinagar, Kashmir, the few residents who dare to break curfew beg soldiers to let them past checkpoints to reach hospitals or find food.
Kashmir's first civilian casualty since Monday
Indian authorities have not built any concrete bunkers in Uri as they have in other areas, so after nearly every major round of attacks, residents have been fleeing to villages and towns farther from the line of fire. Residents see this as a sign of callousness toward Kashmiris. Since 1998, 36 people in Uri have been killed in cross-border attacks.
Police in Uri say that since August, one civilian and one soldier have been killed and seven civilians injured in attacks blamed on Pakistani forces.
Residents say the attacks include mortar rounds as well as bursts of small-arms fire. Dozens of houses have been damaged or sprayed with bullets.
One of Begum's neighbors, Shabir Ahmad Awan, 35, said he was cutting grass in his field Aug. 5 when he heard the first explosion. He ran into a barn where he remained for more than an hour, watching villagers duck behind rocks as mortar shells fell.
The rough terrain and hardscrabble agrarian life are now exacerbated by the increasing hostility between the two nuclear-armed neighbors. Many families have left their villages, some taking shelter with relatives farther from the border, others seeking refuge in the relative safety of the town of Uri.
"We do not want to go back to that hell," said 52-year-old Mohammad Lateef Tarkhan, who fled after his mountaintop village of Churunda was hammered by artillery barrages from a nearby Pakistani military post.
He and three dozen other villagers have been given shelter in a school building about 12 miles away in Uri, 13 families huddling in two classrooms, each measuring about 360 square feet.
"This is not life," he said. "We don't live, we just survive."
Seated in a semicircle on a classroom floor, some residents said their houses were destroyed by the shelling. Manzoor Ahmad said he took his wife and three children to his sister's place on the other side of Churunda after shelling began one night in early November.
Early the next morning, he returned to his house and was stunned to see it had been reduced to rubble.
"When we left, we didn't know where we were heading," Ahmad said. "We just wanted to leave that place. Imagine you are being fired upon from a distance of [about 110 yards], you wouldn't even realize it until you're dead."
To guard against infiltration from Pakistan, the Indian army more than a decade ago fenced in Churunda with concertina wire — a barrier that was recently upgraded to a metallic mesh fence with thermal motion sensors. Only residents are allowed in and out of the village through a 10-foot-wide gate manned by Indian soldiers, heightening the residents' feeling of isolation.
The night that shelling began in Churunda, Habibullah Mir's house in Tilawari was abuzz with excitement over wedding ceremonies for his daughters Shahida and Salma, set for the next day. According to witnesses, during a traditional ceremony at which henna was being applied to the brides' palms, a mortar shell fell 20 feet from the family's house, sending guests scurrying into a cowshed in the back.
They huddled there for nearly two hours until the shelling stopped. One relative was struck by gunfire and underwent surgery. The next day, the weddings took place in simple, solemn ceremonies.
In Madian village a day before the Churunda attack, 19-year-old Ishtiyaq Ahmad was hit in the shoulder by a bullet fired from a Pakistani army post. Witnesses said he lay in a pool of blood for nearly two hours because other residents were too afraid to go to his aid.
"We were able to retrieve his dead body only after the shelling had completely stopped," said Mohammad Yousuf Khan, the village chief.
Apples rot in Kashmir's orchards amid blockade by India
Apple orchards are filled with spoiled fruit and half the crucial harvest is feared destroyed in a nearly three-month clampdown by New Delhi.
Villagers who have vacated their houses have pleaded with Indian authorities to defuse unexploded shells that they fear could cause further deaths or injuries. Riyaz Ahmad Malik, a local administration official, said the army has indicated it won't be responsible for any damage to the houses.
"We are trying to find a way out and hopefully the problem will be solved soon," Malik said.
Since leaving Batgran, Begum has been living with relatives in the village of Thajal, about three miles away, in a makeshift shed with a tin roof that offers little protection from the biting winter.
She was widowed when her husband died of natural causes in 2015. She lost a 10-year-old son to polio in 2017 and has struggled to raise her remaining three children, especially her 8-year-old son Tasleem Ahmad, who is also stricken with the illness.
Begum said she didn't know when she could return to her village. Snow would soon cover Batgran, cutting it off from much of the outside world.
"At times," she said, "I wish that shell had gone off and rid us of the kind of life we are living."
Nanda is a special correspondent. Special correspondent Aoun Sahi in Islamabad, Pakistan, contributed to this report.
Showkat Nanda


Amino acids are building blocks of proteins and peptides. Thus, the knowledge of their structures and names is important not only for chemists, but also for biologists, pharmacists, and just for everyone studying science or medicine.
This app is the easiest and the most efficient way to learn the structures, codes, and properties of 20 standard amino acids (lysine, valine, threonine, and so on) and more than 20 related compounds (such as ornithine, taurine, cystine and others).
* All 22 proteinogenic Amino Acids (20 common + Selenocysteine and Pyrrolysine).
* Three- and One-letter codes (abbreviations): for example, cysteine = Cys C.
* Essential Amino Acids - from Phenylalanine to Tryptophan.
* Polar (aspartic and glutamic acids, arginine) and Hydrophobic Amino Acids (leucine, isoleucine).
* Aromatic amino acids (tyrosine).
* Unnatural Amino Acids such as D-Alanine.
* Dipeptides such as Aspartame.
* Spelling quizzes 'Structure - Name'.
The app is translated into 9 languages, including English, German, Spanish and many others. So you can learn the names of the amino acids in any of them.
- Table of other amino acids.
Animals Quiz - Learn All Mammals and Birds!


Columbia attorneys Cheryl Behymer and Richele Taylor gave presentations at a human resources conference hosted by the South Carolina Hospital Association on February 3, 2011. The program covered HR issues as they relate to the healthcare industry. Cheryl spoke about affirmative action issues and the Office of Federal Contracts Compliance Programs (OFCCP), the branch of the U.S. Department of Labor charged with overseeing affirmative action obligations. Richele addressed issues involving the Genetic Information Nondiscrimination Act (GINA).


text:
Genovation's Electric Corvette Sets a New Record
The street-legal conversion nears 200 mph – and could go faster
By Kristen Hall-Geisler | Published Mar 10, 2016 3:28 AM
Speed Lab
Blog-Network
Genovation Cars
On February 23, 2016, Genovation Cars made some noise (figuratively, not literally) when its GXE, an all-electric 2006 Corvette Z06 conversion, set a new record for fastest street-legal electric car at 186.8 mph. Johnny Bohmer, who has several speed records to his name, was at the wheel, which makes perfect sense. The record was set at the Johnny Bohmer Proving Grounds/Shuttle Landing Facility in Cocoa Beach, Florida.
It may seem excessive for an electric car to use a shuttle landing strip, but it's one of the few places with enough runway—3 miles, to be exact—to attempt high-speed records. The International Mile Racing Association, which certified Genovation's record, measures the vehicle's speed at 5280 feet from a standing start. That leaves two miles to slow down, so contenders don't have to use drag chutes.
Rather than having the black Corvette Z06's original 7-liter, 500-hp V8 engine under the hood, the Genovation GXE has electric motors on board that total 700 hp. And while the gasoline-powered Z06 makes a respectable 475 lb-ft of torque, the GXE has 600 lb-ft.
The GXE is a street-legal car, which according to IMRA rules means it has a valid license plate and is insured to be driven on normal roads, not just at the track. (If a car is aiming for a Guinness World Record, it has to have air conditioning and a passenger seat with a seatbelt. The GXE did indeed have a passenger in that seat, with helmet and race belt, for the record-setting run, though it wasn't Guinness-certified.) Genovation says the GXE has a range of 130 miles when it's not being raced full-out in a record attempt, which is plenty for the daily commute.
The company's CEO, Andrew Saul, said in a press release that the car can do even more, even at the track. The day Bohmer set the record in the GXE was only the car's first day of development testing. Expect to see it setting another record—as long as you don't blink.
Take a peek at the Chrysler Airflow, a sleek new EV concept
Major automakers already have electric vehicles on the market. So what does Chrysler have in store?
Nuro's little grocery-toting robot just got a big upgrade
The third-gen autonomous vehicle now has an airbag. On the outside.
These powerful new electric pickups are about to shock the market
General Motors announced the new Silverado EV this week, but that's not the only impressive electric truck to know about.


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text:
IFRS Foundation report says US SEC's concerns can be overcome
By Ken Tysiac
Three months ago, the US Securities and Exchange Commission (SEC) staff had its say on IFRS. Now the IFRS Foundation is providing its own analysis.
The IFRS Foundation on Tuesday released a detailed, 84-page response to the SEC's exhaustive, 127-page report on IFRS, which was released in July.
The SEC's report outlined concerns it had about the funding of the International Accounting Standards Board (IASB), the timeliness of responses to widespread accounting issues by the IFRS Interpretations Committee and other issues.
The IFRS Foundation, in its report, said some of those problems are being addressed in current initiatives. The IFRS Foundation also contested the SEC's arguments on funding, saying the United States' contributions are lacking in proportion to the size of its economy and its number of representatives in IFRS Foundation bodies.
What's unclear is whether the IFRS Foundation report will make a difference in the SEC's ultimate decision on whether to allow or mandate that US public companies use IFRS for their financial reporting.
Sean Lager, the lead partner in Frazier & Deeter LLC's International Financial Reporting Standards Group, said there has been little movement on the issue since the SEC released its report in July. That report did not make a recommendation on whether US public companies should be allowed or required to use IFRS for their financial reporting.
Lager said IFRS has taken a back seat to other issues with a US presidential election in its final stages.
"You just get more significant events," he said. "And this gets overshadowed."
The report comes a day after American Institute of CPAs (AICPA) President and CEO Barry Melancon, during a speech to the AICPA governing Council, warned that the United States could face consequences for not pushing steadily forward on convergence and adopting IFRS.
Michel Prada, chairman of the IFRS Foundation trustees, said in a statement that the United States is well-placed to achieve a successful transition to IFRS.
"While acknowledging the challenges, the analysis conducted by the IFRS Foundation staff shows that there are no insurmountable obstacles for adoption of IFRSs by the United States," Prada said.
A spokeswoman for the SEC declined to comment on Tuesday.
SEC noted concerns
The issue of IFRS adoption in the United States remains in the hands of SEC commissioners with no known timetable in an uncertain political landscape.
In its July report, the SEC said the standards of the IASB are considered to be of high quality. But the SEC expressed concerns, some of which centred on the IASB's funding.
The SEC staff raised concerns about the IFRS Foundation's reliance on funding from the large public accounting firms, and said fewer than 30 nations contribute to financing of the IFRS Foundation.
In addition, the SEC said, the IFRS Foundation's trustees have been unsuccessful obtaining the funding for the portion of the foundation's budget allocated to the United States. The SEC also said US sources are providing "in-kind" funding such as the efforts by the US Financial Accounting Standards Board (FASB) staff on US GAAP-IFRS convergence projects.
The IFRS Foundation, in its report, responded that:
The SEC analysis overlooked the fact that the biggest contributor to the IFRS Foundation budget is the European Commission, which represents 27 member states. When royalty payments and some voluntary funding arrangements are considered, 69 countries provide financial support for the IFRS Foundation.
FASB's work should not be factored into the US contribution because the convergence programme is a joint process with efforts, resources and benefits shared by FASB and the IASB.
The lack of a publicly sponsored funding arrangement in the United States means that it is not contributing a proportionate amount to the IFRS Foundation's budget. A proportionate US contribution based on GDP would amount to just over £4 million ($6.4 million) in 2012, while £1.3 million ($2.1 million) is expected to be collected.
While 20% to 25% of the seats on the IFRS Foundation's bodies are held by US representatives, US contributions make up less than 10% of the total country contributions to the foundation's budget.
"Ultimately the lack of public funding in the US can only be resolved by the US authorities themselves, directly or indirectly," the IFRS Foundation staff wrote.
Funding may be the biggest obstacle for IFRS adoption for US public companies, because the SEC cannot act as a fundraiser for a private organisation, and payment to the IASB could be viewed as a foreign subsidy.
The IFRS Foundation report also said:
The IFRS Interpretations Committee has implemented changes that will make it more effective; the SEC had expressed concerns about the committee's failure to address issues on a timely basis.
The IASB has begun preparatory work to establish an Accounting Standards Forum comprising national standard-setters and other regional bodies to provide feedback. The SEC had recommended that the IASB should extend its involvement with national standard-setters.
Costs of transition to IFRS for US preparers should be reduced compared with other countries because the convergence programme has reduced differences in standards.
The IFRS Foundation report included an appendix describing a review of academic research on the benefits of IFRS adoption, noting that the SEC staff report did not analyse the benefits of IFRS in the United States.
The IFRS Foundation also said those benefits could not simply be projected onto the United States because it already has high-quality accounting standards that are understood globally. Nonetheless, the report said that, in many ways, the United States is better prepared than other jurisdictions to consider the adoption of IFRS.
"While the size of the US economy relative to other jurisdictions presents significant challenges in transition that are unique to the US," the report said, "the experience of other countries suggests that many of the challenges can be overcome with the appropriate political will to make a commitment to the mission of a single set of global standards."
—Ken Tysiac (ktysiac@aicpa.org) is a CGMA Magazine senior editor.


After teasing it earlier this month, Jaguar is now revealing in full the XFL which as the name implies is a long-wheelbase XF.
Created for those who can't afford the XJ, but want more rear legroom than the regular XF, Jaguar is introducing the XFL exclusively for the Chinese market. It debuts today at the Beijing Auto Show where one its main rivals is also celebrating its premiere, the stretched Mercedes-Benz E-Class. Compared to the standard model, the XFL is 5.5 inches (140 mm longer) and brings an extra 6.1 inches (157 mm) of rear legroom. In addition, those sitting in the back will also get to enjoy an additional 4.5 inches (116 mm) of knee room.
The design of the car hasn't really changed compared to the standard-wheelbase XF, but obviously the wheelbase was stretched and now the rear doors are longer. Jaguar developed the XFL specifically for chauffeur-driven customers so focus was in the rear where there are eight-inch screens integrated in the back of the front-seat headrests.
The China-only XFL uses Jaguar's latest 10.2-inch InControl Touch Pro infotainment system which works together with a 17-speaker, 825-watt Meridian Surround Sound System. As one of the attached images show, rear passengers have access to lots of buttons as well as to 2x HDMI ports, 2x USB 3.0 ports, and a 12V power socket.
The heated rear and cooled rear seats benefit from four-way lumber adjustment and also have massaging functions. Passengers are further pampered with an air-cleaning ionization system, window blinds, and folding tables.
Jaguar will sell the XFL exclusively with an all-wheel-drive system and an eight-speed ZF automatic transmission. Around 441 pounds (200 kilograms) heavier than the standard variant, the stretched model will be available with a turbocharged 2.0-liter, four-cylinder engine delivering 197 hp & 236 hp. Those in need of more punch will be able to opt for the beefier 335-hp supercharged 3.0-liter V6.
It's worth mentioning the XFL is going to be the first China-specific product from Jaguar Land Rover and will be assembled in Changshu where the Discovery Sport and Evoque come to life.


TOMBALL, TX – Most people are in a good mood on Fridays. That apparently wasn't the case with Harris County Attorney Susan Sciacca.
Tomball Police say she got into a bit of trouble after what started with a fit of road rage.
According to 911 recordings, a man cut Sciacca off on Highway 249, and she didn't take too kindly to that.
The two ended up in a parking lot where they both called the cops.
Whoa. Sciacca immediately came clean about the gun.
Prosecutor or not, you can't go around threatening people with pistols.
Cops showed up and arrested Sciacca and charged her with aggravated assault with a deadly weapon.
She appeared in court Tuesday.
As for the folks at the Harris County Attorney's Office, they say they're continuing their review of this matter.
It just goes to show, it doesn't matter who you are; You're not above the law.


text:
import socket

import Axon
from Kamaelia.Apps.JMB.WSGI import WSGIFactory
from Kamaelia.Chassis.ConnectedServer import ServerCore
from Kamaelia.Protocol.HTTP import ErrorPages
from Kamaelia.Support.Protocol.HTTP import HTTPProtocol

port=8080

#This is just a configuration dictionary for general WSGI stuff.  This needs to be passed to the handler
#to run
WsgiConfig ={
'server_software' : "Example WSGI Web Server",
'server_admin' : "Jason Baker",
'wsgi_ver' : (1,0),
}

#Now we need to tell the server how to find the applications.  We do this by creating a URL routing list.
#What this essentially does is tell the WsgiHandler where to find the modules containing the WSGI Applications.

url_list = [
    {
    'kp.regex' : 'simple',
    'kp.import_path' : 'Kamaelia.Apps.JMB.WSGI.Apps.Simple',
    'kp.app_object' : 'simple_app',
    },
    {
    'kp.regex' : '.*',  #This is the entry for the 404 error handler.  This basically says "match everything else."
    'kp.import_path' : 'Kamaelia.Apps.JMB.WSGI.Apps.ErrorHandler',
    'kp.app_object' : 'application'
    }
]

def main():
    #This line is so that the HTTPRequestHandler knows what component to route requests to.
    routing = [ ['/', WSGIFactory(WsgiConfig, url_list)] ]
    server = ServerCore(protocol=HTTPProtocol(routing),
                        port=port,
                        socketOptions=(socket.SOL_SOCKET, socket.SO_REUSEADDR, 1))
    print 'Serving on port %s' % (port)
    server.run()

if __name__ == '__main__':
    main()

redpajama_set_name: RedPajamaGithub