text:
BrightSurf Science News
The targeted LHRH analog AEZS-108 alters expression of genes related to angiogenesis and development
The cover for issue 2 of Oncotarget features Figure 5, "MASPIN can prevent the formation of UPA - UPA-receptor complex by a single step, and thus decrease the possibility of the abnormal degradation of the ECM, the development metastasis and angiogenesis," by Fodor, et al.
In the present study, the research team investigated AEZS-108 induced cytotoxicity and the altered mRNA expression profile of regulatory factors related to angiogenesis and metastasis in LHRH receptor-positive OCM3 cells.
Their results show that AEZS-108 upregulates the expression of MASPIN/SERPINB5 tumor suppressor gene, which is downregulated in the normal uvea and UM specimens independently from the LHRH receptor-ligand interaction.
In order to investigate the mechanism of the induction of MASPIN by AEZS-108, OCM3 cells were treated with free DOX, D-Lys6 LHRH analog, or AEZS-108.
Dr. Gabor Halmos from the University of Debrecen, Department of Biopharmacy, in Debrece, Hungary as well as the Veterans Affairs Medical Center, Endocrine, Polypeptide and Cancer Institute, in Miami, FL, USA said, "Although uveal melanoma (UM) is a rare disease, it is the most prevalent lethal ophthalmological tumor."
The discovery of specific receptors for peptide hormones on cancer cells has led to the development of cytotoxic or radiolabeled hormone analogs that are appropriate for tumor localization and targeted therapy.
AEZS-108 guides the chemotherapeutic agent specifically to those tumors that express LHRH-receptors, which could result in targeted cytotoxicity and less damage to healthy tissues.
The authors reported that previously OCM3 UM cell line expresses the receptor of LHRH localized on the cell membrane and in the cytoplasm, rendering them susceptible to AEZS-108 uptake and the detection of the LHRH receptor in OCM3 cells has led to the use of AEZS-108 for targeted therapy of the tumor.
Moreover, that the OCM3 UM cell line expresses the LHRH receptor and LHRH rendering them susceptible to AEZS-108 uptake.
The Halmos Research Team concluded, "In summary, our data confirmed previous results showing LHRH receptor expression in OCM3 cells, a UM in vitro model. Furthermore, we report for the first time that AEZS-108 causes changes in the expression of genes that are involved in angiogenesis and ECM degradation and which might inhibit cell proliferation and induce apoptosis in OCM3 cells.
These findings suggest that AEZS-108 plays a pivotal role in the regulation of angiogenesis and tumor suppression. Taken together, targeted cytotoxic LHRH analogs, such as AEZS-108, might serve as an effective treatment for patients with LHRH receptor-positive uveal melanoma."
Impact Journals LLC
Related Angiogenesis Articles from Brightsurf:
Oncotarget: miR-151a enhances Slug dependent angiogenesis
Volume 11, Issue 23 of @Oncotarget reported that the authors have previously established that mi R-151a functions as an onco-mi R in non-small cell lung cancer cells by inducing partial EMT and enhancing tumor growth.
A newly identified mechanism can be targeted to boost angiogenesis
Scientists of the National Center for Cardiovascular Research (CNIC) have discovered a cellular and molecular mechanism that can be exploited to induce productive and sustained angiogenesis in tissues that have become ischemic due to reduced blood supply.
Blood runs deep: Lab blood vessel model sheds light on angiogenesis
Researchers at the University of Tokyo and at CNRS in France revealed the importance of the molecule EGFL7 for angiogenesis and endothelial integrity using an artificially created blood vessel model called a microvessel-on-a-chip.
FDA-approved drug may block resistance to anti-angiogenesis therapy
A Massachusetts General Hospital research team has identified a potential strategy for improving the efficacy of angiogenesis inhibitors, drugs that help fight cancer by blocking the formation of new blood vessels.
Genome editing with CRISPR-Cas9 prevents angiogenesis of the retina
A research team from the Schepens Eye Research Institute of Massachusetts Eye and Ear has successfully prevented mice from developing angiogenesis of the retina--the sensory tissue at the back of the eye--using gene-editing techniques with CRISPR-Cas9.
NYU Tandon's 3-D microscopic voyage at SXSW spotlights angiogenesis research
High school seniors accepted to NYU Tandon School of Engineering will receive 3-D cardboard viewers that will take them on a journey to a microscopic, intracellular world -- a virtual reality (VR) game environment where they can watch cells communicate using chemical signals.
Heart bypass without surgery? -- AGGF1 induces therapeutic angiogenesis through autophagy
Coronary artery disease, the number one killer world-wide, restricts and ultimately blocks blood vessels, cutting off oxygen supply to the heart.
Going to 'Wars' against cancer and heart disease
Wars2 was discovered to be involved in angiogenesis -- blood vessel formation, which is important in ensuring that all parts of the body get nutrients to sustain life.
Targeting 2 angiogenesis pathways could improve results of glioblastoma treatment
Two companion papers from Massachusetts General Hospital research teams suggest that targeting multiple angiogenesis pathways simultaneously could help overcome the resistance to anti-angiogenic treatment inevitably developed by the devastating brain tumor glioblastoma.
Read More: Angiogenesis News and Angiogenesis Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.


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Justice for Nirmala
IGP Gyawaly blames coronavirus for delays in Nirmala case
Published On: July 2, 2020 07:40 PM NPT By: Anjali Subedi
KATHMANDU, July 2: When Sarbendra Khanal was the Inspector General of Nepal Police (IGP), Thakur Gyawaly, the current IGP was one of the senior investigating officers deployed to resolve the rape and murder of Nirmala Panta. Both the IGPs had said in interviews in February that the Nirmala case will be a top priority. While Khanal had stated that 'the police has already come to a conclusion on its part and only some legal processes remain for the end result; Gyawaly had asserted that giving justice to Nirmala would be one of his topmost priorities.
Gyawaly is retiring this week. Talking to Republica on Tuesday, he said that the coronavirus pandemic has kept Nepal Police busy, overshadowing the Nirmala rape and murder case. When reminded that the police have been investigating other cases at a normal pace, Gyawaly stated that 'wrapping up the case was not given due attention'.
Nepal Police IGP Thakur Prasad Gyawaly
This has disheartened Nirmala's mother, Durga Devi. According to her, the culprit is roaming free and the state mechanism is not eager to arrest him. "I was also in the dark. I thought he was innocent. But after watching his videos, and getting to know him more, we gathered more information. I have been saying that he's the one; I filed a case against him. But why have they not taken this seriously? If my reading and intuition is wrong and there's some other man behind this, let them bring that person to me!" she challenged. Speaking to Republica over the phone on Wednesday, Durga Devi stated that she and her two daughters feel vulnerable as 'the man behind the crime' fearlessly roams around her house.
By 'he', Durga Devi meant a local of Kanchanpur, Dilip Singh Bista, 42. Her firm stand against Bista over time not only irked some activists who wanted a 'VIP criminal' to pop up in the case, her relationship with her estranged husband soured. He has been living with his second wife for over a decade. After Yagyaraj, her husband, thrashed and beat her for wanting to take compensation from the government six months after the incident, the two have rarely spoken to each other.
Nirmala's dead body was found on a sugarcane field on July 27, 2018 in Kanchanpur, a few kilometers away from her house. She was last seen alive at her friend's house (Bam family) where she had gone for a group study a day before the tragedy. The police soon made public Bista as the prime suspect. But his DNA report did not support the claim. On the other hand, Nirmala's father Yagyaraj Bista's brother Khadak Singh and a local reporter Khem Bhandari, among others, accused the police of framing Bista, who 'does not even look straight into a girl's eyes, let alone touch her'. This triggered protests in Kanchanpur. Tensions grew when Sunny Khunna, 17, died and Arjun Bhandara, 20, was severely injured in police firing on August 24.
Things worsened as 'Manaskhand', a local newspaper, owned by Bhandari ran one after another misleading stories that demonized Bam sisters and the local police. The stories spread like a wildfire on digital platforms; protests across the country rocked the nation. Several investigation committees were formed, police personnel faced departmental actions for 'administrative negligence', and the protesting party that included Durga Devi filed a case against eight police personnel 'for tampering with evidence'. Over time, fabricated stories were exposed.
Bista, the accused, was never a man who could stay away from girls. His suppressed sexual tendencies often resulted in abnormal behaviors. He lamented that girls don't come to him; his marriage has not been arranged yet. "My brother doesn't care; perhaps he fears that he has to share the land," Bista told this during a conversation with a freelance journalist Umesh Shrestha, who did a series of in-depth reporting in Nirmala case and posted youtube videos of the same.
For months since the incident, police were trying to match the DNA of suspects to the sample collected from Nirmala's vaginal swab. The DNA tests proved them wrong.
The National Human Rights Commission then questioned the validity of the male DNA found in the swab itself. A team of experts, led by Jiwan Rijal, reported technical flaws. The police finally ruled out DNA as a proof and turned to circumstantial evidence. This, once again, dragged Bista to the case. Moreover, after the police headquarters in February scrapped the report of the investigations led by AIG Dhiru Basnet, which showed Bista as an innocent man and pointed figures toward the investigating officers, the case took a different turn. The headquarters directed the Kanchanpur District Police to follow the new investigation report prepared by a review committee under the leadership of DIG Suraj KC. This was a twist in the story, and Nirmala's mother was hopeful for justice.
"Nirmala's mother went through unimaginable pains. If it's anyone that needs justice, it is Durga Devi. If justice prevails, her two daughters and she will see a new dawn. But the police and the lawyers are dilly dallying, I do not know why," said a local activist Maya Negi, who has known Durga Devi for a long time. "I feel that this case can be solved with determination. Both the police and the legal agency should have that deep urge to deliver justice. Blaming the pandemic for the delays is a lame excuse," she added.
Nirmala_case
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redpajama_set_name: RedPajamaCommonCrawl


I was never sure if I would be cut out to work for myself. I am not exactly the entrepreneurial type (or so I thought) until I took the leap around four years ago. I felt right there and then that it would be a huge risk, but I also realized that without going full time, it would be tough to get anywhere with this "hobby". If I were going to take the next step with this venture, I would have to get serious.
It has worked better than I expected, all things considered. I wanted to be my own boss primarily to maintain a flexible schedule for my family, but it turns out that work / life balance can be elusive, depending on how you decide to live your life (and especially for those of us who have Type A personalities). To date, I now work on several projects and businesses (both internet based as well as traditional). My internet business experience actually encouraged me to try out other types of flexible work, and it's been working very well so far. At any rate, there are some really great benefits to becoming an entrepreneur. Not only is this an endeavor where you aim to make money, but the lifestyle itself allows you to save quite a bit of money.
So if you're working on a side business, some of the considerations below may just convince you that going full-time with your own venture(s) is worth trying. These financial benefits may just tip things in favor of full time entrepreneurship!
1. No costs for traveling to work.
I have never gotten tired of getting up by 7am, getting dressed, having breakfast and then starting work in the room next door by 7.30 AM or thereabouts. There is no stress gained from jostling with loads of other people on the train or in traffic, and I don't have to stress about having to be somewhere else by a certain time. If I am a few minutes late I don't have to grovel to the boss either. What could be better? If I need to take a break, I can take one at anytime; later on, I can perhaps make up for the work I miss. I've saved quite a bit when you consider the gas and parking fees I used to pay each work day. I've written about this in my article on how we've trimmed gas costs (and saved around $5,500 per year).
2. No corporate clothes to buy.
I used to have jobs where I needed to wear a "business uniform" and had to buy certain types of clothing so I looked the part. Now that I work from home, I get to choose what I wear and I always make sure I feel really comfortable in it. There's nobody I have to meet in person, so it doesn't matter if I wear jeans and a t-shirt or anything else I so choose 😉 . With the nice weather we're having here these days, I can wear shorts or light trousers if I want, and there is no corporate style to adhere to at all. I don't have to worry about setting aside a special clothing budget any longer. Because of the extra savings, I now have more of my money going towards savings.
Perhaps one of the best money saving advantages of working from home is the fact that I don't have the temptation to eat out during lunch. I also don't have to spend time the night before preparing a packed lunch. Instead, I can take a break whenever I'm hungry (not when my boss says I can) and make something fresh if I want to. Try taking something healthy like sardines on toast to work and see if your colleagues won't mind! You can easily do this at home though.
4. No need for extra babysitters?
My kids are of school age and one of the big positives of working from home is the ability to be around when your children are home from school. When they were very young and I was fully employed, I used to worry about this exact issue. For those of us living in California, it can be tough to live on one income (unless you really tighten your belt or have an enormous one person salary), so this was one situation I thought deeply about. The solution we ended up with that ultimately worked out pretty well was to work for ourselves! This has also allowed us to skip or control the one expense that many dual income families are forced to take on, especially if they don't have the benefit of family or friendly neighbors nearby — paying extra for after school care or activities.
5. You can claim quite a number of tax deductions.
One of my favorite benefits for being your own boss is to be able to write off a lot of business expenses. Lots of savings here; I reckon I've saved quite a bit with the help of home office deductions and I don't feel half so guilty when I opt to upgrade my computer, laptop or favorite electronic gadget. And what about travel costs? Internet marketing and blogging conferences have been good excuses for me to visit new places while traveling for business.
There are many other ways I've been able to cut costs and earn even more through my business, but these are the main methods that stand out for me. And when you add up those savings over a year or so they really make a huge difference. I know that if I can save, say several thousand dollars a year because of these advantages, I can earn a few thousand dollars less a year without it adversely affecting my financial situation.
So would you consider taking the plunge yourself?
Created August 1, 2010. Updated November 4, 2012. Copyright © 2012 The Digerati Life. All Rights Reserved.
I like the post SVB, and I think a lot of us would love to be able to work from home or untethered and make a decent living that way.
I'd actually be more interested in reading about the things you don't like about working at home, and some of the things people don't talk about that may wear on you. Whatcha think? Can you write a follow up post about that topic? I think it'd be great!
Thanks for the great suggestion! Yes, certainly, I can write a follow up on this post about what some of the issues are with the whole work at home situation. The biggest thing of course is the lack of compartmentalization. I find myself doing more and more work (yes, despite a lot of outsourcing that I already do) and struggling a bit more with the whole work/life balance.
Very ironic, since one of the reasons that I had for going this route is to try to IMPROVE my work/life balance…. I never realized what a challenge it would be! I'd love to expound on this issue a bit more some time. Thanks so much again for the interesting suggestion, Sam!
The benefits you describe are NOT benefits for a typical self-employed person running their own business. I've owned 4 different businesses over the past 30 years, and am currently retired, and I can tell you that 1-5 are a dream for a self-employed person.
1-5 may be a reality for a form-home-blogger, but it certainly does not reflect the reality of owning your own company.
You definitely made good points. I clarified the title of the article to reference the online business world. This article refers to the issues faced by a small business owner who runs an online business. It could refer to a blogger who wants to make some money, or to those people who freelance from home. Or it could refer to an internet marketer who does their hustling over the web. I should have clarified things more carefully.
One must note though, that running an online business is vastly more general than running a blog. There are many ways to make a buck via the internet, and blogging is just one of those avenues.
Then again, I know someone who owns a couple of brick and mortar stores that he runs successfully from home. And what about those real estate business owners (I suppose you can call them investors as well)? Lots of them hire local managers who do a lot of the day-to-day work while the owners attend to other things. It's all about how you decide to set up your business, I suppose.
Working from home is, I must admit, beneficial in the terms you have described above. A few days ago I ran into somebody who explained that, ever since he had started to work from home, he noticed how many bad habits corporate jobs create. And he's right. So I would extend your concern for corporate clothes to a much larger set of things.
As a recently married working bee who spends 40+ hours in a cubical all week, I have been trying to plan out doing something on my own. It is going to have to start out part time, but if all goes better than well, I hope to take the same jump as you after a few years (I have to submit the business plan to my wife of 3 weeks for approval first!).
I really think some of the tax benefits are huge allowing you to equip yourself with whatever is necessary to get the job done. The key word there is "necessary" and not "wants".
I love the post because it really is practical b/c we spend entirely too much money on clothing and food for our corporate jobs because WE HAVE TO! I have to wear a shirt and tie everyday, if a suit was required, i'd be in a heap of trouble!
Great work, it's great encouragement for people like me who have a tiny vision. I'll bug you some more as it progresses!
I'm looking forward to reading your follow-up post about some of the – challenges you face working for yourself too.
The tax deductions alone are enough to make the move. Plus, when you're working for yourself, your conscience eliminates the downtime for you. All that time you waste working for The Man seems especially fruitless when The Man is you.
Great post. I quite like doing this blogging thing on the side (though it is starting to get a bit difficult juggling a full time job and blogging) because it gives me some balance. For example, if I get sick of blogging, I can look forward to work for a change of pace and vice versa. Though not having to get up and tackle traffic would be a huge incentive.
You forgot getting up and finishing when you want!
Great list of benefits of working from home. I have recently gone back to work now that the kids are off to college. We own our own business so I am doing my work primarily from my family room with my lap top. It is great for all the reasons your post cited. I do get a bit lonely sometimes. A little face to face time with people is a nice bonus of going into the office a couple of times a week.
I've always had my own business except for four years when I worked for a large mutual fund company. Being self employed is the best lifestyle I know – there's nothing better than being in control of your own destiny. Your hard work pays off in your bank account not your employer's. Learning how to be self employed does take practice, but truly committed people can do it!
1. You do not have companions with whom you can chit chat.
2. You are more engrossed into your work, that shift the balance of your personal and professional life.
3. There is no regular income, so there is a risk involved.
4. You always have to motivate yourself, there is nobody else to motivate you.


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Home > Departments > Social Work >
Medical Social Work Department
The Mission of the Medical Social Work Department is to provide an effective medical social work service which facilitates optimum social and emotional wellbeing among patients and those affected by their illness.
The department provides a range of supportive services to patients, families and those affected by illness and hospitalisation. Services include:
Counselling relating to illness and its impact on their family. Issues regarding discharge from hospital and after-care are also addressed by the Medical Social Worker.
S/he may help you access services such as further rehabilitation, community supports, respite care, convalescence and long-stay nursing homes.
Information on welfare entitlements may also be obtained from the medical social work department.
Our department also offers bereavement support and crisis help following traumatic events.
Liaison with statutory and voluntary groups is also an integral part of our work. There are many support groups to which patients and families can be referred outside the hospital.
Each medical social worker provides a service to one or more hospital consultant.
A Psychosocial Assessment is used to help determine whether people are experiencing difficulties as a result of illness or admission to hospital. A Psychosocial Assessment includes assessment of patient's social, emotional and environmental circumstances. It enables the Medical Social Worker to assess the impact of illness on a patient or his/her family and plan appropriate supports.
Patient/ Family Support
This refers to interventions by the Medical Social Worker which provide patients and families with general psychosocial and practical support at times of ongoing stress related to illness and hospitalisation.
This service can include practical or counselling interventions offered to patients and families at the time of an acute crisis, such as sudden death, admission to Intensive Care, admission following an accident or assault.
This is a therapeutic process between a patient or family member and the Medical Social Worker, focussing on adjustment and coping strategies in relation to life crises such as serious illness/trauma or bereavement.
This begins at the point of admission. Its purpose is to assess the psychosocial and environmental factors, which can impinge upon the patient's transition from hospital back to their community setting.
Information / Advice
This may relates to social welfare benefits, Health Service Executive payments and services
Bereavement Service
In addition to bereavement counselling provided by individual social workers, the Social Work Department co-ordinates a parent's bereavement support day, the remembrance service for children who have died in the hospital, and an annual bereavement support programme incorporating a group process.
Referrals can be made by the Hospital team, nursing staff, clinical support staff, families or patients themselves. Our core office hours are Monday to Friday 9 am – 5pm. Closed for lunch between 1 and 2pm
Principal Medical Social Worker
Telephone: 01 8092589 / 01 8093290
Our main reception is opposite Clinic D on the Out Patient Department corridor
Standards pertaining to Professional Practice
Professional qualified social workers operate within the parameters of the Code of Practice for Irish Association of Social Workers' Members (2008) and the IASW Code of Ethics (2006). The recently established Health and Social Care Professionals Council will provide a statutory framework of regulation for the profession.


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A Glimpse Into London's Early Sewers
Reprinted from Cleaner magazine
Cleaning Up London's Drains and Sewers
BY MARY GAYMAN
Once the idea of using water to carry away human wastes was accepted,
LondonÕs Commission of Sewers set out to drain the city by means of large egg-
shaped tubular sewers fed by "tubular pipes" from individual homes and
businesses.
After many studies, it became evident that interior "smoothness" of the
pipe was a critical factor in moving waterborne wastes along the new system.
Glazed or salt clay was said to be far superior to other materials. When
properly installed at the right slope, with correct sizing and even
workmanship, the commission argued that "the use of glazed clay tubes has been
hitherto remarkably successful." By 1847 Commission reports show that "between
10 and 11 miles of earthenware pipes are sold weekly, which is at the rate of
2,600 miles of new sewers each year."
"Three fourths of the stoppages of tubular house drains were found to
have been occasioned by bad laying of the pipes, wrong levels, and reversed
inclinations. Many pipe drains have been so laid as to create obstructions and
these failures, though the causes are obvious and gross, have been eagerly
held forth as proofs of failure of the principle."
Dr. Dalby, a physician reporting to the commissioners, claimed that
"choking of the pipe" was the likely source of three cases of typhus in one
household.
It was said that "it would be better for the inhabitants of many houses
to pay for new tubular drains every year than to run the risk of having them
stopped up every month and than to have the large drains detaining and
spreading the deposit and facilitating decomposition within the walls and
beneath the floors of their dwellings."
Acceptance of the entire drainage idea was in question after the cholera
epidemic hit in 1849. As the public panic grew, "every pipe makerÕs yard was
cleared out."
During this period, pipe was made by "persons not overly scrupulous,
eagerly purchased, and hastily laid by parties utterly ignorant of any role of
correct drainage," creating doubts about the validity of the new scheme. The
commission found itself having to defend the continuation of conversion from
cesspits to tubular drains.
Poor design and bad workmanship led to frequent and expensive failures
and digups from stoppages and collapses. In most residences, the house was
drained from the back, through the house into the sewer placed in the center
of the front street.
A study of pipe construction found that "offensive and noxious matter
was carried completely under the house, instead of directly away from it, and
the chances of stoppages were increased in proportion to the increased
frictional area and to the diminution of the fall."
"By these ignorant and mischievous arrangements, when a stoppage does
occur, it can frequently be remedied only by taking up the floor boards of the
front as well as the back room, and opening of the foot and carriage pavement
to the sewer in the centre of the street, all which work must be done at great
inconvenience and at oppressive expense."
Sewer gases from the main sewer came back up into the houses. Doctors
visiting the sick reported "offensive smells and excessive state of impurity
in the air at the dwelling houses." These "miasmas" were blamed as typhoid
fever and cholera continued to plague the city." Meanwhile, large sewers in
the street were being redesigned of brick in the new "egg" shape.
Water As a Cleaning Tool
An experiment on street cleaning with fire hoses led to the first use of the jet hose to clean street surfaces, drainage slots and sewers. At a demonstration of high pressure hoses, the fireman was directed to cascade the water down the side of a building to "cleanse the walls from urine stains and other filth." The Mayor of London asked that the hose be directed at the pavement (deep in horse manure) to see how effectively it could be removed from the cobbled surfaces. Since the sewer drain in the center of the street carried cesspit wastes as well as horse manure and street sweepings, the grid on top of the sewer was removed and the slop was flushed with high pressure water. The commissioners were amazed to see the buildings, streets and sewers so clean and rushed back to breathlessly report this new wonder to the Commission of Sewers. "The Mayor, the Town Regent and many other influential persons were present. The hose was of leather, 3 inches in diameter and about 60 yards long, with a discharge pipe 1 and 1/4 inch in diameter. The carriageway is from 20 to 24 feet wide and about 150 yards long. It was washed almost as clean as a house floor within five minutes." "The surface of the reservoir is 350 feet higher than the point of discharge, and 2557 yards from it. The time occupied and the efficacy of the cleansing experiment depended, of course on the quantity and force of the water." An all out effort was launched to determine the cost of "cleansing with water" versus the labor for sweeping, shoveling, scrubbing and hauling away caked-on manures and other wastes. It was proven that water was cheaper by far. Once this report was made on this method, the Commission of Sewers conducted many tests to determine the pressures, volume of water and effect of hoses lengths on pressures at the nozzles. "It will be obvious that this saving of time and labour would also be of great importance as affecting the cost of any system of public cleansing by the agency water." Commission engineers also calculated the loss of pressure from the outlet or pump to the "nozzle" at one pound per lineal foot of hose. Operators of jet cleaners today must also compensate for pressure loss. Longer hoses need increased pump pressures to deliver optimum results.
Pipe Sizing Critical to Assure Flow of Wastes in Water
Hydraulic action of water within the pipe was calculated to size pipe for maximum flow characteristics. Eventually the standard was set at 3" for laterals, leading to 9" intermediate pipe and finally to the main, which was deemed most effective at 75 times the area of the lateral and 8-1/3 the area for the intermediate pipe. The development of egg shaped brick sewers may have come from the existing V-shaped street and sewer drains which were gradually covered with arched brick to enclose the open trench. In the next of this series the distinctive characteristics and benefits of egg shaped sewer channels will be discussed. Trial and error eventually settled on the ratio of sizes which remain at 3" for laterals in the UK and in much of Canada. It is interesting to note that the Uniform Plumbing Code for California now prefers 3" laterals for new houses to compensate for the low flow devices mandated as water conservation devices.
Water Consumption Key to Estimating Sewer Loads
The 1841 census showed that there were 270,000 houses in the metropolis. Based on this data, commission engineers made the following dispute of water usage and drainage needs. "Now, if each home were to have at least a 9 inch drain, and you and other architects recommend, it appears that the area of the stream or river required to keep them full and flowing would be a stream 1,132 feet in width by 105 in depth ... Yes? "It is estimated that a supply of water for the whole of the metropolis, supposing each house to have a supply of 125 gallons per diem, or 25 gallons per head (5 per household) would be given by a circular tunnel or aqueduct of proportionate size to your number of houses, say, one fourth. "Such being the estimate of size of conduits required to bring in water, it is presumed that the sectional areas of the drains and sewers would not be required of vastly greater size, supposing them to have as good a fall, the carry away the same water." "It is stated that the smaller the pipe is, generally, the less likely will deposit accumulate. What is your opinion on the subject?" "My opinion is this; I will take the case of the washer to the sink being open and the cook throwing down anything that comes to hand; it comes against a 4 inch pipe and it blocks completely up; but the end of a cabbage stalk will pass into the 9 inch drain, and there it will lie and decompose." Therefore, the chief, if not the only reason assigned for making the intermediate drain at 9 inches diameter, is that of preventing it stopping or choking, an effect which its large size and sluggish flow almost inevitably occasions." The arguments as to cleaning and gravity flow lead to countless studies of the power of water to suspend and remove solids. It was generally agreed that a wide flat channel (like that of a meandering river) tended to accumulate sediment, while a narrow channel carrying the same volume of water was purged of sediment. The one would deposit silt or sand, the other would most certainly remove both. The egg shaped sewer promised both capacity at storm flows and self cleaning flows at low levels of use. == Caption Text, for those without graphical browsers: 1. "Three-fourths of the stoppages of the tubular house-drains are however, upon inquiries which the Board have made as to the working of the new system, found to have been occasioned by bad laying of the pipes, at wrong levels, or at reversed inclinations; of which the following cross section presents an example of not unfrequent occurrence; in which, instead of the fall being made uniform or regularly progressive from the point A, to the outlet C, to save a slight additional expense of extra digging the drain is brought close under the floor from A to B, and the greatest fall is given at the outlet." 2. At a demonstration of high pressure hoses, the fireman was directed to cascade the water down the side of a building to "cleanse the walls from urine stains and other filth." 3. "Jet" cleaning of streets, buildings and sewers was a sensation with the public.
Republished courtesy of Cleaner Magazine, a publication of Cole Publishing Inc., POB 220, Three Lakes WI 54562, tel. 800-257-7222 or 715-546-3346, and author Mary Gayman.
Return to the Sewer History area of the SwopNet Engineering Databank. You will find Part 3 of the Sewers of London history there, as well as the Thomas Crapper photo site.


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Q: Execute sql statement or procedure in .net entity framework core I created ASP.NET 5.0 Core-Web-API project and use package Microsoft.EntityFrameworkCore version 5.0.13. Additionally I created a stored procedure with 2 parameters of type DATE. The procedure runs in sql management studio without errors.
var p1 = new SqlParameter("@From", System.Data.SqlDbType.DateTime);
p1.Value = new DateTime(2021, 11, 07);
var p2 = new SqlParameter("@To", System.Data.SqlDbType.DateTime);
p1.Value = new DateTime(2021, 12, 07);
List<MapTableDimvw> myList = myDbContext.MyTable.FromSqlRaw("EXEC myProc @From, @To", p1, p2).ToList();

A: I think you can do with the following :
var blogs = context.myTable
.FromSqlRaw($"Select Id, colA, colB From myTable")
.ToList();
// or AsEnumerable();
var blogs = context.myTable
.FromSqlRaw($"Select Id, colA, colB From myTable")
.AsEnumerable();

Source: Raw SQL Queries
Otherwise, you can try to add something like this :
var simple = _context.myTable.FromSqlInterpolated($"Select Id, colA, colB From myTable").ToList();

Regards.

redpajama_set_name: RedPajamaStackExchange


In 1941, the British General Staff began examining the feasibility of mounting a high velocity gun into infantry and cruiser tanks. The need arose from experiences against the Afrika Corp during the campaign in the Western Desert and the requirement for a gun capable of knocking out any known German armoured fighting vehicle.
The A30 was based as many Cromwell components as possible and mechanically it was almost identical, featuring the same Rolls-Royce Meteor engine as the Cromwell and was developed by BRCW. The development of the turret to house the 17pdr was entrusted to Stothert & Pitt, a firm that normally specialised in the manufacturing of large cranes and was derived from the turret they had tested on the TOG 2.


text:
Why rush...
THE NEW BLUE?
TEN REASONS TO RUSH
1. Our eclectic repertoire has something for everybody, and it's always evolving. We belt out pop and soul, we power through epic 13-part rock arrangements, we take pride in our folk roots, we snap through jazz standards, and we are always looking for new genres to explore. Our arrangements, all created by members of New Blue current and past, have won awards and acclaim. Our musical personality is especially unique in its emphasis on rockin' bass lines and the value of the low female voice. You heard us, altos. This solid foundation allows our soprano voices to soar.
This video features Victoria Hall-Palerm, also a member of Yale's prestigious senior ensemble, Whim 'n Rhythm, singing her farewell solo in 2014. Each year during Parents' Weekend, New Blue greets family and friends with an on-campus concert, in which our seniors perform their favorite solos and our new taps make their debut!
2. We record and professionally produce a new album every other year. Last fall, we released our latest album, Exit 4, which was recorded in the spring and features 10 never-before-recorded arrangements, as well as a handful of classic favorites. And we still have available our previous album, Clarion Call, which features previous classes of New Blue. Check out clips here!
3. New Blue loves to travel! In recent years, we have toured the U.K., France, San Francisco, Ireland, Texas, Greece, D.C., Florida, Hong Kong, Singapore, St. Louis, Chicago, London and countless other exciting places. We try to visit our members' hometowns on our domestic tours, and it's always incredible to perform for family, friends, hometown choirs, and Yale Club members across the country. On our international tours, one each other year, we've performed for schools, embassies, and sold out halls. We had the opportunity of being the first Yale group to sing with Yale-NUS's first a cappella group on their campus. (We even had a riff-off with a guys' group while checking out Portobello Road market on our London tour — they were not ready for Caitlin's solo on our Taylor Swift mashup, "Blank Space!")
4. You can get involved right away. As a member, you'll grow as a musician and a professional, with opportunities to take part in business and tour managing, artistic direction, design, communications, and group finances. And anyone, even freshmen, can try any solo. Anytime. We're also proud to continue collaborating with causes that our members work hard for. We recently sang for patients at the Connecticut Mental Health Center and special needs students at Our Pride Academy, and participated in benefit concerts for Nothing But Nets and World Vision.
5. Worried you'll never hang out with a guy again if you join an all-female a cappella group? You're in for a surprise. A cappella at Yale is a huge community of friends, and you'll find yourself recognizing people from other groups right away — or at least after our first party with them on Tap Night. We regularly perform with Yale groups, teaming up with a guys' group on campus, the Yale Alley Cats every year for Parents' Weekend, and singing with Mixed Company, the SOB's, and the Spizzwinks at Harvard-Yale. New Blue also frequently performs with groups from other schools, including prominent groups from Harvard, Williams, MIT, and the reigning ICCA finalists from Oxford. Plus, with Annalise as our social chair, you'll have plenty of opportunities to bond with other groups, from sunny Old Campus picnics to themed parties.
6. New Blue is classy.
7. The friendships and connections you'll make through New Blue will last a lifetime, as we've discovered at our Alumnae Dinner, held annually in New York. The great diversity of interests and experiences within the group makes life as a member of the New Blue family truly one-of-a-kind. The group includes women from Michigan to Thailand, pre-med students and music majors, varsity athletes, photographers, and actresses, and a whole lot more. Our different backgrounds, worldviews, and academic interests only strengthen the bonds that we form based on our shared love of singing and of one another. Welcome to one of the most loving, open environments you'll find at Yale.
8. New Blue is sassy.
9. We take pride in countless New Blue traditions: gathering at the Women's Table; performing in our black power blazers and rompers in addition to our little black dresses and evening gowns; singing our alumnae song, "Runs in the Family"; baking together (have you heard about puppy chow and Oreo truffles? Get ready to hear a lot about puppy chow and Oreo truffles); holding a holiday gift exchange; and delivering singing Valentines to unsuspecting classmates every February, just to name a few. Every spring, New Blue presents a full-length, on-campus concert for our friends, fans, and alumnae. We had a blast at our 45th anniversary weekend reunion and jam on Saturday, April 11th, 2015, with alums from the 70's all the way to today, pictured below!
Check out videos from current and past jams on our YouTube channel.
10. As a member of the first women's organization on campus, you'll be connected to a long legacy of strong women at Yale, through both our music and our history. The first women of The New Blue were instrumental in establishing the vibrant coeducational community that we still enjoy at Yale today, and our supportive network of alumnae stretches across the country and the globe. To quote a former member: "This is forty[-five!] years of women creating together, traveling together, managing a business, performing together, having fun, maintaining musical excellence, and never letting the Old Blue know what hit them."


The tutorials in this archive contain code which enables you to add a image after the header in different Genesis child themes using different methods. The code is guaranteed to work as shown in the demo images and videos. Installation of all code as well as support for PHP code is provided for members.


P. Alex Linley and Susan Harrington discuss academic and applied perspectives on strengths psychology.
What are your strengths? In everyday conversation people are generally modest and reluctant to talk about their strengths. When asked this question in an interview, most people feel slightly awkward and tend to rely on formulaic answers designed to create a positive impression and improve their prospects of interview success. Likewise, surveys that ask people to name their strengths have found that only about one third of people can readily name their own trait-like strengths (Hill, 2001; cf. Arnold, 1997). Could this simply be a reflection of natural reserve? Or is it that we just don't know what our strengths are? Possibly, but all this may conceal a deeper truth: that we often do not fully appreciate our strengths, and may not even know what they are.
This reluctance to talk about one's strengths is also reflected in psychology, where strengths have been the subject of very little systematic empirical research. However, with the advent of positive psychology, this is now changing. In this article we review the historical context of psychological work on strengths, consider approaches to strengths from both academic and applied perspectives, and identify some of the most exciting potential applications of putting strengths into practice in education, work and life.
Character is personality evaluated, and personality is character devaluated. Since character is an unnecessary concept for psychology, the term will not appear again in this volume… (Allport, 1937, p.52).
was decisive (Nicholson, 1998). Personality psychologists since Allport have almost totally ignored the concepts of character and virtue, from which a psychology of strengths would be derived, and this has been one factor that has led to the predominant focus on dysfunction and disorder within psychology.
However, these questions of character and virtue are now squarely on the agenda of psychology once again, with the new emphasis on positive psychology underpinning the development of theories, classifications and measures of character strengths (Peterson & Seligman, 2004). Most importantly, psychologists are now beginning to provide a common vocabulary for researchers and practitioners interested in the good life of happiness, health, well-being and fulfilment, just as the Diagnostic and Statistical Manual of Mental Disorders has done for researchers and practitioners interested in psychopathology, illness, disorder and distress (Linley & Joseph, 2004a).
Positive psychology began with Martin E. P. Seligman's (1998) APA Presidential Address (Seligman & Csikszentmihalyi, 2000), and a major early initiative was the development of a scientific classification of strengths. The classification (see box) included 24 character strengths, based on brainstorming, extensive literature searches and the subsequent application of 10 criteria for a character strength. These criteria were developed through scrutiny of the candidate strengths and the identification of common features among them (see Peterson & Seligman, 2004). Although the criteria are neither necessary nor sufficient conditions for character strengths, they are considered to be pertinent features that, taken together, capture a 'family resemblance'. Importantly, Peterson and Seligman (2004) note: '…we intend these strengths as neither exclusive nor exhaustive, but we expect that subsequent research will help us achieve a nearly exclusive and exhaustive list' (p.13). Hence, the door is very much open for further revisions to this classification, and for a new generation of psychologists (and others!) to make their mark through improved theory, measurement and application of character strengths.
Another approach to strengths psychology has been taken within applied settings, largely through the auspices of Don Clifton at the Gallup Organization in the United States (Hodges & Clifton, 2004). Clifton argued consistently that the two most prevalent assumptions about human nature are flawed: that anyone can learn to be competent in almost anything, and that a person's areas of greatest potential for growth are in their areas of greatest weakness. In contrast, Clifton argued, first, that each person's talents are enduring and unique, and second, that each person's greatest room for growth is in the areas of their greatest strengths (Buckingham & Clifton, 2001). If this doesn't seem to fit with you, think about this: How many times do the same shortcomings keep coming up in your annual appraisal (or those of your staff), and how many times are you (or they) sent on training courses to address these 'developmental opportunities', but with little, if any, sustained effect? Still we persist in believing that weaknesses can be fixed and that they provide our greatest potential for development and growth.
However, Clifton argued that 'to produce excellence, you must study excellence', and took a very different approach. In order to establish the factors that facilitated top-level performance across a number of different professional occupations, Clifton and his team of researchers at the Gallup Organization interviewed thousands of professionals with the aim of identifying the themes of talent that differentiated the top performers from the rest. Strengths were developed from one's innate talents, they argued, through the application of knowledge and skill. Working from these definitions, Clifton and the researchers at the Gallup Organization identified hundreds of themes of talent from their interviews with professionals, but condensed these to the 34 most prevalent themes (see Buckingham & Clifton, 2001, or Clifton & Anderson, 2002, for details).
It is unfortunate that, given the commercial sensitivity of much of this research data and material, it has not typically been published in mainstream sources, such as academic journals (but see Schmidt & Rader, 1999, for a discussion of the development of structured interviews for strengths). Accordingly, the applied strengths perspective has not engendered the consideration that it may warrant. This problem is representative of some of the issues that plague occupational psychology, and provide an unfortunate obstacle to the integration of academic research and applied practice (Anderson et al., 2001), a point to which we return below.
Reviewing these academic and applied approaches to understanding the psychology of strengths, a notable demarcation arises. Academic approaches have arrived at classifications of strengths derived from reviews of existing literatures and the application of inclusion and exclusion criteria. While this approach does allow some semblance of order and the delineation of naturally arising distinctions, it is also (perhaps unnecessarily) restrictive. In contrast, applied approaches have arrived at differing classifications of strengths from studying strengths in practice across thousands of professionals. While this approach has clear applied value, it might be argued that it lacks an integrative conceptual framework that allows a deeper understanding of the structure and taxonomy of strengths. Which is right?
As an academic psychologist, one's interest is likely to be in how best to 'carve nature at the joints'. That is to say, one may wish to develop a taxonomy of strengths based on a deep theory that explains why this construct is a strength while that one is not, and how each strength relates to each other strength at varying levels of hierarchical abstraction (Bailey, 1994).
As a practitioner, one's interest may be less in how best to carve nature at the joints, but rather more directly in 'What works?', 'What are the benefits?' and 'Does this classification system answer the questions that are important to me, such as allowing measurement of strengths that are predictive of performance and achievement in my domains of interest?' Here, the theory may not be so much important as the practice, but critically, one must be able to demonstrate the benefit.
the development of the theory and measurement of strengths. At some ideal future time, we may yet find that the two are able to integrate, as researchers identify natural classifications that meet the applied needs of practitioners, thus allowing the 'new dawn' that occupational psychology is striving for (Hill, 2003).
As a first step in this direction, we define a strength as a natural capacity for behaving, thinking or feeling in a way that allows optimal functioning and performance in the pursuit of valued outcomes. 'Natural' refers to the fact that strengths are partly innate, but are shaped by our environmental experiences that may facilitate the development of some strengths, but impede the development of others. This process of natural selection mirrors neural development and brain plasticity, since as some neural connections (which underpin strengths) are used and strengthened, so others go unused and wither. 'Natural' also indicates that strengths are largely stable, in the tradition of personality stability, but can be more or less developed by our psychological activities and experiences. Just as personality may flex according to the demands of the situation, but be stable and consistent over time (Fleeson, 2001), so strengths may fluctuate according to situational demands, but will always remain largely consistent.
a lower-order factor of one or more of behaving, feeling or thinking.
'Optimal functioning and performance' are hallmarks of a strength, since refinement of a strength is the royal road to operating in a way that is the most efficient and effective we can possibly be. Using our strengths comes naturally to us. We yearn to use our strengths, we feel fulfilled when we use our strengths, and we achieve our goals efficiently and effectively when we use our strengths.
'Valued outcomes' are deliberately broadly and loosely defined, since they may include happiness, health and well-being from an individual, personal perspective (Linley & Joseph, 2004a); increased productivity, sales, turnover and profit from a business perspective (Hodges & Clifton, 2004); or goal attainment from any perspective.
However, 'valued outcomes' should be interpreted as descriptive, and not prescriptive (Linley & Joseph, 2004a). Valued outcomes may be intrinsic or extrinsic, individual or communal. Different outcomes may be valued at any of the individual, couple, group, community, society, regional, national or international levels, and it is not for us as psychologists to specify which 'valued outcomes' are right and which are wrong (Linley & Joseph, 2004b). While the exercise of a strength per se should not diminish others (see Peterson & Seligman, 2004), there can and probably will be differences and even conflicts in the valued outcomes that strengths are used to pursue.
A notable point in this regard is the goal to which strengths are applied. Strengths may be used in the pursuit of 'good' objectives (e.g. world peace) or 'bad' objectives (e.g. inciting hatred and violence). There is nothing implicit within a strength that necessarily determines it as 'good' or 'bad'; rather, the goals to which a strength may be applied are themselves subject to our own value judgements. This should be an important consideration for future research.
Work continues apace on the development of theories and measurement of strengths, but it is already possible to envisage the potential benefits of applying a strengths framework within organisations. Such a framework would provide the consistent building blocks for defining an organisation's processes for recruitment and selection, career development and succession planning, performance appraisal, individual development and team building. Furthermore, it would provide the language to create a strengths culture throughout the organisation, providing a logical, progressive flow from initial recruitment and onwards through all aspects of an individual's career with the organisation.
of applying a strengths framework. First, strengths are grounded in psychological constructs that can be defined and measured. Second, strengths are, by their very nature, natural capacities within individuals that, when played to, allow the individual to achieve optimal functioning and performance. For individuals within organisations, a clear understanding of their strengths allows them to exploit and optimise their prevalent strengths, and to gain awareness of those areas where they they are not so strong. They can then seek to work in a way that plays to their strengths, while managing their weaknesses through complementary partnering and team working with others.
For example, an individual whose key strengths at work are organisational ability and a meticulous eye for detail may excel in a project management role. This same individual may not, hypothetically, be very empathic. Hence while they may be extremely good at ensuring a project is delivered on time, this may be at the expense of people's feelings. Given that an increasing amount of organisational work is conducted in teams, a strengths-based approach would suggest constructing the project management team on the basis of complementary strengths profiles. Our hypothetical project manager might benefit by having a people-oriented person in the team, who has empathic strengths, and so can deal effectively with people's feelings, while the project manager deals with the more task-focused project delivery.
By exploring each individual's pattern of strengths, the emphasis becomes one of optimising what people are best at, while recognising and managing those situations that they may not handle naturally well, and addressing these through appropriate job allocation, complementary partnering, or strengths-based team working, rather than trying perennially to 'address their weaknesses' and rectify the fact that people may have been put in the wrong job to begin with.
Overall, a strengths-based formula for organisational success would be to play to your strengths (through identifying them and finding a role that is congruent with them), develop your competencies (through ensuring that you are at least minimally effective in critical areas of the job), and manage your weaknesses (through job redesign, complementary partnering, or strengths-based team working).
From a team-building perspective, a strengths framework provides individuals with a language to gain a greater understanding of each other's behaviour at work, and a new context within which to view these behaviours. An understanding of each person's strengths provides an insight into how and why team members could work more effectively together.
From a manager's perspective, a clear articulation of the strengths of their individual team members provides them with an understanding of which individuals may excel at certain tasks and why. Further, it enables the manager to provide individualised management and developmental support to each team member in accordance with their own unique combination of strengths. Finally, at an organisational level, a strengths approach provides a way of articulating the key human resource requirements needed to meet current and future business goals, and to ensure that individuals are recruited, developed and managed in a way that is based on their own individual strengths, in tandem with the strengths needed to meet the goals of the organisation.
Strengths psychology offers much to the understanding of constructive human nature, and provides psychologists with a rare opportunity of working with people in a way that enhances their identity and self-worth and respects their individual talents and potentialities. Career selection, recruitment and development; coaching in both business and personal settings; specific strengths-based therapies; building self-esteem and developing new skills with offenders; using one's strengths to guard against mental and physical decline in old age; all these areas could benefit from strengths psychology.
to do more of what they are good at.
Some might argue that we have been here before, and that research on what we have described as strengths (e.g. creativity, humour, hope) already exists. Indeed it does, and this provides a foundation on which strengths psychology can build. However, what has been missing until now is an integrative framework of strengths that allows strengths to be studied and understood in relation to each other, rather than in isolation. We suggest that these are exciting times for strengths psychology, and, more exciting still, we suspect that the best is yet to come.
- P. Alex Linley is at the University of Leicester. E-mail: [email protected].
- Susan Harrington is a Director of Potenthos Ltd. E-mail: [email protected].
Adapted from Peterson & Seligman (2004, pp.29–30).
Which is most effective – building strengths or repairing weaknesses?
Can playing to your strengths be a bad thing?
Would you like to use your strengths more? Why?
Should organisations do more to capitalise on people's strengths? Why?
Have your say on these or other issues this article raises. Write to our Letters page on [email protected] or contribute to our online forum via www.thepsychologist.org.uk.
Allport, G.W. (1937). Personality: A psychological interpretation. New York: Holt.
Anderson, N., Herriot, P. & Hodgkinson, G.P. (2001). The practitioner–researcher divide in industrial, work and organizational (IWO) psychology: Where are we now, and where do we go from here? Journal of Occupational and Organizational Psychology, 74, 391–411.
Arnold, J. (1997). Managing careers into the 21st century. London: Paul Chapman.
Bailey, K.D. (1994). Typologies and taxonomies: An introduction to classification techniques. Thousand Oaks, CA: Sage.
Buckingham, M. & Clifton, D.O. (2001). Now, discover your strengths: How to develop your talents and those of the people you manage. London: Simon & Schuster.
Cawley, M.J., Martin, J.E. & Johnson, J.A. (2000). A virtues approach to personality. Personality and Individual Differences, 28, 997–1013.
Clifton, D.O. & Anderson, E.C. (2002). StrengthsQuest: Discover and develop your strengths in academics, career, and beyond. Washington, DC: Gallup Organization.
Fleeson, W. (2001). Toward a structure- and process-integrated view of personality: Traits as density distributions of states. Journal of Personality and Social Psychology, 80, 1011–1027.
Hill, J. (2001, April). How well do we know our strengths? Paper presented at the British Psychological Society Centenary Conference, Glasgow.
Hill, J. (2003). Bleak future or new dawn? The Psychologist, 16, 137–138.
Hodges, T.D. & Clifton, D.O. (2004). Strengths-based development in practice. In P.A. Linley & S. Joseph (Eds.) Positive psychology in practice (pp.256–268). Hoboken, NJ: Wiley.
Linley, P.A. & Joseph, S. (2004a). Applied positive psychology: A new perspective for professional practice. In P.A. Linley & S. Joseph (Eds.) Positive psychology in practice (pp.3–12). Hoboken, NJ: Wiley.
Linley, P.A. & Joseph, S. (2004b). Toward a theoretical foundation for positive psychology in practice. In P. A. Linley & S. Joseph (Eds.) Positive psychology in practice (pp.713–731). Hoboken, NJ: Wiley.
Nicholson, I.A.M. (1998). Gordon Allport, character, and the 'culture of personality': 1897–1937. History of Psychology, 1, 52–68.
Peterson, C. & Seligman, M.E.P. (2004). Character strengths and virtues: A handbook and classification. Washington, DC: American Psychological Association.
Schmidt, F.L. & Rader, M. (1999). Exploring the boundary conditions for interview validity: Meta-analytic validity findings for a new interview type. Personnel Psychology, 52, 445–464.
Seligman, M.E.P. & Csikszentmihalyi, M. (2000). Positive psychology: An introduction. American Psychologist, 55, 5–14.


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As A Perceived Storm Brews, Distressed Players Gear UP For Their Turn But When WIll It COme? –
The times are good for traditional buyout shops, right? Deals are getting done with speed and relative ease; the debt markets, though they may have pulled back a tad since the beginning of the year, are still eager to hand out loans amounting to 5x to 6x EBITDA; and more and more funds continue to hit their hard caps as institutional dollars flood the market. And despite the phrase "seller's market" becoming the cliche of 2005's private equity scene, buy-side confidence has never seemed so high.
But the mainstream buyers are not the only ones smiling at the market's current state. Players in the distressed debt and turnaround markets are taking a hard look at what's going on in the market and are optimistic that it's only a matter of time until a number of companies fall from their highly-levered grace.
Currently, industry pros say the visible signs that distress is on the way are subtle but compelling, including a slight up-tick in the high yield default rate, recent hikes on interest rates, excessive leverage and the cyclical nature of the market. Whatever the drivers are, investors and market researchers are betting that 2006, 2007 and 2008 will end up being prime years for acquiring companies out of bankruptcy or those in default to their creditors.
Stephen Moyer, director of research at Imperial Capital LLC, a boutique investment bank in Los Angeles, says the new wave of distressed companies can already be seen, and one need not look back too far to find its origins. "We're seeing troubled companies right now that are from deals completed just months ago. When markets forget the past, companies end up being financed up to 5x to 6x leverage, and there are only a handful of companies out there that can really handle that kind of debt."
Cyclical Reasoning
"On average, three years after a big year in high yield issuance, there is an echo boom in bankruptcies, restructurings and turnarounds," says Michael Psaros, a founding and managing principal at KPS Special Situations Funds. And according to information compiled by UBS, the high yield market has been booming for just about three years. In 2003, $135.7 billion in new junk bonds hit the market (at the time, the second-largest amount ever next to 1998's $150.6 billion), and that was followed by 2004's record-breaking high of $154.5 billion in new issuance, while 2005 saw about $85.5 billion in high yield bond issuance as of the close of the third quarter.
But while there have been some prominent bankruptcies lately, including Delphi Corp., Delta Air Lines Inc. and Northwest Airlines Corp., at the moment they are typically seen as one-offs that are not indicative of the rest of the market and the overall numbers seem to reflect this assessment. According to Moody's Investors Services, the trailing 12-month high yield default rate is only at 1.91%, while the forecasted default rate for one year down the road is currently set at 3.4%, still below historical averages.
Martin Fridson, publisher of Leverage World, a research service focusing on the high yield market, says these low default rates are probably the result of the higher quality of junk issuers in 2001 and 2002. Throughout that two-year period, Fridson says, only 40% of junk bond issuers were rated B or CCC, while the remaining 60% were rated BB, the highest grade available in the high yield market.
Conversely, though, from 2003 to the present, Fridson says that issuer quality has become a mirror image (60% B and CCC; 40% BB) of what it was, meaning that the default rate is probably bottoming out right now and is likely to climb in coming years. "I think we're likely to see a peak in default rates in 2008," Fridson predicts.
But high yield isn't the only thing investors are looking at when they surmise that distress is on the way. The second lien market, which has only really been developing over the past few years, has captured the attention of small and mid-market turnaround players. From 2002 to 2004, the market for second lien loans has grown from being a $630 million marketplace to one worth nearly $12 billion, according to CIBC World Markets.
"We believe that the key investors in second lien (hedge funds) are not emotionally involved, and when things go bad, there will not be buyers for that debt," Psaros says. "Plus, as a legal matter, there is no real history of second liens being litigated in the bankruptcy courts, so there is no precedent to be followed."
Distressed Minds Think Alike
In the meantime, both full- and part-time distress players are getting their houses in order and readying their war chests in their efforts to time the liquidity cycle.
In July, WL Ross & Co. closed on about $1.1 billion for its WLR Recovery Fund III LP, the firm's largest distressed fund to date. The Blackstone Group last month closed on more than $500 million for its inaugural distress-focused fund-the first investment vehicle for the firm's recently formed Blackstone Distressed Debt Advisors-and Avenue Capital Group, which typically invests in debt obligations and other financially distressed companies, is readying for a final close on its $1 billion Avenue Special Situations IV LP later this month.
"There is a bunch of money being raised for distressed funds; it's a true cycle-play," says Stephen Presser, a partner at Monomoy Capital Partners. "Over the past two years there has been a tremendous amount of liquidity in the larger and high yield markets, and people are beginning to look at those credits and figure that with all that leverage, even a slight ripple could put those bonds in trouble."
However, some market pros hold that this level of interest in distressed debt could bring the market to previously unseen levels of efficiency, a factor that could have adverse affects on returns.
"At the moment, there is more cash out there than distress to invest in," says one market analyst speaking on condition of anonymity. "In 1990 and [19]91, you had no distress-dedicated capital out there, so when things went bad there was a lot of unclaimed paper out there that was bought up for very cheap. The same thing happened in 2001, when the price of defaulted bonds was worth about 25 cents on the dollar. But now, with all the demand we're seeing, it's more like 50 [cents] to 60 cents on the dollar."
Such admonitions, however, seem to fall by the wayside of firms like The Carlyle Group that are bent on investing in distressed assets. Carlyle is reportedly in the market to raise a $400 million fund geared toward investments in bank loans, public debt and structured equity of distressed companies. The firm hired Brett Wyard to serve as managing director and co-head of its distressed investing group.
Coincidentally, Wyard was hired away from private equity turnaround firm Oaktree Capital Management, which also just wrapped up its own fundraising drive in November. OCM Opportunities Fund VI LP closed with $1.77 billion in limited partner commitments.
Is This Really Happening?
But while billions of dollars are raised for what some anticipate being the business world equivalent of The End of Days, hundreds of traditional private equity firms continue to raise new funds and churn out highly-levered deal after highly-levered deal, which begs the question: Why?
"I don't see any sign that [a downturn] is around the corner," says David Lobel, a managing partner at Sentinel Capital Partners, "There are certain dislocations, however, such as the auto market and airline industry. But if you take a look at the macro, this economy is quite resilient despite all the recent hits it's taken, such as [Hurricane] Katrina and [the war in] Iraq."
Indeed, Moody's issued a caution last month noting that the anticipated credit cycle peak that's driving all this activity could be a mirage. It notes that the historic record "warns against extrapolating too much bad news from a mild rise by the U.S.' high-yield default rate."
Citing a recent example, Moody's says that amid a previous credit cycle upturn, the U.S.'s high-yield bond default rate temporarily rose from March 1995's 1.4% to the 3.8% of February [through] March 1996. "Thereafter," Moody's says, "profit margin widening and the enhanced coverage of interest expense would lower the speculative-grade default rate to April 1997's localized bottom of 1.7 [percent]."
That said, nobody is willing to bet that the market will remain unscathed for a protracted amount of time. Lobel notes that with companies as highly levered as they are today, even a 2% slip in the economy could have disastrous affects on a number of them, and he went on to say that Sentinel-which does make investments in distressed lower-middle-market companies-has begun spending more time and resources looking at the sector, as of late.
"The thing in distressed you have to be careful for is getting in too early," Lobel says. "It's like trying to catch a falling knife. You never want to try and catch a falling knife. You want to let it fall first, and then pick it up. If something has negative momentum it will take you down with it a lot faster than you can pick it up."


We've seen some glorious April weather here in London, and those bright Spring skies inspired us to think about colours, how we define them and how that language changes over time. In the English language blue clichés abound: out of the clear blue sky, blue sky thinking, black and blue...but did you know that the word blue is actually absent from many languages around the world?
The journey of colour vocabulary through the ages is a window into the ability of language to expand in order to reflect diversity and individual perceptions in all sorts of fields.
For example, former British Prime Minister William Gladstone, who was also a keen classicist, pointed out the unnerving lack of colour in classical Greek literature, such as Homer's Odyssey. One of Gladstone's hypotheses was this: did this mean that several millennia ago, the human race could simply not see colours? Anthropological research into native languages says no; they just didn't have a word for them. Language is functional and if there was never any reason to describe or refer to something in everyday life, why would there need to be a word for it?
The first use of the word blue appeared in Ancient Egyptian. As a population whose industry was widely considered world leading in its time, the experimentation and creation of dyes drove the Egyptians to create vocabulary to describe and differentiate these colours from each other. With industry and trade came competition and choice, and so language had to cater for this too.
We now know that languages are constantly evolving to accommodate changes in industry and society. Concepts such as sexuality and mental illness are constantly being better defined by language. These concepts are not just now being invented; like the colour blue, they have always existed, but until a certain point, were nameless.
The right language gives people crucial tools to understand and convey their feelings effectively - it empowers them. A heartening thought on a bright blue day.


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longevity - August 04, 2021
𝐒𝐜𝐢𝐞𝐧𝐭𝐢𝐬𝐭𝐬 𝐮𝐧𝐥𝐨𝐜𝐤 𝐠𝐞𝐧𝐞𝐭𝐢𝐜 𝐬𝐞𝐜𝐫𝐞𝐭𝐬 𝐨𝐟 𝐩𝐥𝐚𝐧𝐭 𝐭𝐡𝐚𝐭 𝐥𝐢𝐯𝐞𝐬 𝐟𝐨𝐫 𝐭𝐡𝐨𝐮𝐬𝐚𝐧𝐝𝐬 𝐨𝐟 𝐲𝐞𝐚𝐫𝐬
'It's just a really super weird thing,' says plant geneticist Andrew Leitch
If you want to understand the science of longevity and perseverance, you can't do much better than the Welwitschia plant.
Considered one of the toughest and longest-living plants, a Welwitschia can survive for thousands of years in the bone-dry deserts of southern Africa. And as long as it's alive, it never stops growing.
That's why scientists have studied the DNA of the Welwitschia, in the hopes of unlocking the secrets of its incredible ability to survive for millennia in extremely inhospitable conditions.
"It's just a really super weird thing," Andrew Leitch, a plant geneticist at Queen Mary University of London and one of the study's authors, told As It Happens guest host Katie Simpson.
Andrew Leitch, a plant geneticist at Queen Mary University of London, co-authored a recent study that examines how the Welwitschia plant lives for so long. (Submitted by Andrew Leitch)
"That's why you study weird and wonderful organisms — because they give you weird and wonderful insights that point you to directions you might never have thought of going."
Their findings were published last month in the journal Nature Communications.
'Two leaves that never die'
Welwitschia plants grow in the extremely arid desert along the border of southern Angola and northern Namibia. Scientists believe they get most of their water from morning mists that roll in from the Atlantic Ocean, condensing on their leaves and absorbing through their pores.
In Afrikaans, Welwitschia plants are called "tweeblaarkanniedood," which translates to "two leaves that cannot die."
Those two leaves grow continuously for thousands of years like some kind of infinite ticker tape, all the while cracking, splitting, sprawling and curling, giving the illusion of multiple leaves — or looking like "a giant green octopus," as Leitch puts it.
"They're coming out from under these giant woody lips like a leafy conveyor belt which never stops growing," he said.
He noted that in the 19th century, the director of the Kew Gardens in London said "it was out of the question, the most wonderful plant ever brought to the country and one of the ugliest."
Ilia Leitch of Kew Royal Botanical Gardens in London studies a Welwitschia plant. (Submitted by Andrew Leitch)
The Welwitschia's leaves protect an area called the basal meristem, which Leitch says is the key to its longevity.
Most plant leaves grow from the tip outward. But the Welwitschia's two leaves grow continuously from the base, with the meristem supplying them with a constant stream of fresh cells.
"They protect that meristem with all sorts of genetic tricks. And those are the things that we were looking at in the genome," Leitch said.
New study finds natural forests are rebounding around the world, but can't outpace deforestation
Scientists discover 1st evidence of 40-million-year-old Antarctic frog
The researchers say they've identified large numbers or copies of genes connected with efficient metabolism, cell growth and stress resilience.
But while the base keeps growing, the ends of the leaves eventually die, either drying up in the sun, or getting slowly nibbled away by various other desert lifeforms. Only damage to the base of the plant will threaten its livelihood.
"Animals do in fact, eat the leaves, but damage those meristems stems under the lips, and that's it," Leitch said. "So, you know, they're very vulnerable at some level, as well as being extremely robust."
A male Welwitchia plant in the Namib Desert near Swakopmund, Namibia. (Wolfgang Kaehler/LightRocket/Getty Images)
Leitch says the Welwitschia's genetic advantages could someday be applied to other crops.
"We've identified in this plant some genes that are important … and it could be that we now have targets, new targets, that we might be able to look at in agriculture," he said.
"And so that's why you do these things. As well as, of course, the fundamental biological insight it gives you to study weird plants where pretty well everything about them is unusual."


SKF and Peugeot S.A., and several group companies, (PSA) have settled their dispute before the Competition Appeal Tribunal in the United Kingdom regarding damage claims resulting from SKF's settlement with the European Commission for violation of European competition rules. PSA initiated this lawsuit against several bearing manufacturers, among them AB SKF, in February 2016.
"A strong and growing dividend is a focus of our capital allocation strategy to create long-term value for our shareholders," said Richard G. Kyle, Timken president and chief executive officer. "This dividend increase reflects the company's financial strength and our confidence in our strategy and future growth prospects."


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Hans Meinhardt (* 23. Dezember 1938 in Mühlhausen (Thüringen); † 11. Februar 2016 in Tübingen) war ein deutscher Naturwissenschaftler. Meinhardt ist bekannt für seine Pionierarbeiten auf dem Gebiet der Musterbildung in der Biologie.

Leben
Meinhardt studierte Physik in Heidelberg und Köln und promovierte in Köln 1966. Seine Dissertation war über ein Thema der schwachen Wechselwirkung und speziell den Betazerfall, worüber er am Zyklotron des Max-Planck-Instituts für Kernphysik in Heidelberg forschte. Anschließend arbeitete er zwei Jahre am CERN in Genf an Computersimulationen. Danach wandte er sich der Biologie zu und wechselte zum Max-Planck-Institut für Entwicklungsbiologie (damals Max-Planck-Institut für Virusforschung) in Tübingen, an dem er bis zu seinem Tod wirkte.

Wissenschaftlicher Beitrag
Meinhardt beschäftigte sich mit der Entstehung von Mustern an wachsenden Organismen, wie zum Beispiel auf dem Fell des Zebras, auf den Schalen von Meeresschnecken. Anfangs befasste er sich in der Gruppe von Alfred Gierer in Tübingen mit Modellierung der Entwicklung von Hydra. Für die Wirbeltier-Extremitätenentwicklung entwarf er 1983 ein Modell der mehrstufigen Genaktivierung, das er 2009 ausbaute. Auch mit der Bildung von Mittellinien (Körperachsen) von Bilateria-Embryos, dem ersten strukturbildenden Entwicklungsschritt, befasste er sich.

Meinhardt setzte grafische Computermodelle ein, um Systeme partieller Differentialgleichungen zu finden, deren Lösungen den an den Lebewesen beobachteten Mustern entsprechen. Die Gleichungssysteme geben wiederum Hinweise auf die Struktur der unbekannten biochemischen Systeme, die die Muster hervorrufen. Die Arbeit Meinhardts, der lange zusammen mit Alfred Gierer publizierte, gehört zu den Pionierarbeiten auf dem Gebiet der phänotypischen Musterbildung.

Die Idee des Turing-Mechanismus', die den beiden Forschern 1972 noch nicht bekannt war, wurde unabhängig von Turings Arbeit von 1952 durch Meinhardt und Gierer formuliert und gleichzeitig maßgeblich erweitert. Ihr Modell von 1972 erklärt erstens, wie eine lokale, sich selbst verstärkende Quelle (Aktivator) für das Morphogen erzeugt werden kann und führt zweitens die laterale Inhibition ein, wodurch neue Prinzipien der Musterbildung, z. B. Streifen, beschrieben werden konnten. Gierer und Meinhardt erweiterten ferner die musterbildenden chemische Diffusionsprozesse Turings auf Zellebene aus, so dass phänotypische Muster durch Zell-Zellreaktionen dargestellt werden konnten. Die Modelle wurden später in der Literatur Local activator lateral inhibitor models bzw. LALI-Modelle genannt.

Siehe auch
 Musterbildung
 Nichtlineares System

Schriften

Artikel
 mit Gierer: A theory of biological pattern formation, Kybernetik, Band 12, 1972, S. 30–39
 Eine Theorie der Steuerung räumlicher Zelldifferenzierung, Biologie in unserer Zeit, 1979, Nr. 2, S. 33
 Generation of biological patterns and form: Some physical, mathematical, and logical aspects, Progr. Biophys. Molec. Biol., Band 37, 1981, S. 1–47
 mit M. Klingler: A model for pattern formation on the shells of molluscs, J. theor. Biol, Band 126, 1987, S. 63–69
 Gierer-Meinhardt Model, Scholarpedia 2006
 Models of biological pattern formation: from elementary steps to the organization of embryonic axes, Curr. Top. Dev. Biol., Band 81, 2008, S. 1–63
 Auf- und Abbauprozesse von Mustern in der Biologie: Strukturbildungsprozesse, Biologie in unserer Zeit, Band 31, 2001, Nr. 1, S. 22–29
 Die Simulation der Embryonalentwicklung, Spektrum der Wissenschaft, März 2010

Weitere Publikationen siehe: ResearchGate Publikationsliste Hans Meinhardt

Interview
 From observations to paradigms; the importance of theories and models. An Interview with Hans Meinhardt Online

Bücher
 Models of Biological Pattern formation, Academic Press 1982
 The Algorithmic Beauty of Sea Shells, 2. erweiterte Auflage, Springer, Berlin, Heidelberg, New York 1998, 3. Auflage 2003, ISBN 3-540-63919-5. (Deutsche Ausgabe: Wie Schnecken sich in Schale werfen)

Literatur
 Patrick Müller, Christiane Nüsslein-Volhard: Obituary: Hans Meinhardt (1938–2016), Development, Band 143, 2016, S. 1231–1233

Weblinks

 Interview mit Meinhardt bei Current Biology, 2008

Einzelnachweise

Entwicklungsbiologe
Theoretischer Biologe
Physiker (20. Jahrhundert)
Deutscher
Geboren 1938
Gestorben 2016
Mann

redpajama_set_name: RedPajamaWikipedia


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Mantra Yoga (devanagari: मन्त्र योग), una delle branche dello Yoga che propone come via di realizzazione spirituale la recitazione (japa) dei mantra.

Sebbene l'uso dei mantra sia molto antico nella storia dell'induismo, il Mantra Yoga è descritto in numerosi testi di epoca tarda, quali la Mantrayoga Saṃhitā (XVII-XVIII sec.), la Yogatattva Upaniṣad (successiva al XIV sec.), la Mantra Kaumudī, ecc.

Note

Collegamenti esterni

Yoga
Meditazione


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using NModule.Core.Module;
using NModule.Dependency.Core;

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namespace NModule.Core.Test.nm_ur {
	public class nm_ur_01d_module {
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redpajama_set_name: RedPajamaGithub


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LECRAE RELEASES THE ROAD TO RESTORATION: THE MAKING OF THE ALBUM A THREE PART YOUTUBE VIDEO SERIES
With his 9th studio album, Restoration, dropping on August 21st and the follow up to his New York Times best-selling book, I Am Restored: How I Lost My Religion, But Gained My Faith, releasing on October 13th, Lecrae is giving fans a behind the scenes view of his life in The Road To Restoration, a 3 part video narrative posted on his YouTube channel""Restoration is taking something broken and making it whole again," explains Lecrae. Through restoration we take something that has been stripped of its value and bring back its worth, meaning, and purpose. I want people to journey with me on The Road To Restoration. The journey begins with this 3 part video experience, then there's the album, Set.Live virtual concert, and book! Collectively they're all pieces of a puzzle and each piece helps you to understand the next. When all the pieces come together, you'll get the full picture."
The YouTube video series begins with The Road To Restoration: The Dreamer (Part 1) opening with a 14 year old Lecrae sharing his dream of growing up to become a rapper, family man, and businessman!' The irony of watching the young 8th grader, is not only did he become a rapper, but he would become a multi Grammy Award-winning platinum selling artist who made history as the first artist to debut in the #1 spot on Billboard's Top 200 and Gospel Album Chart in the same week! Now also husband and father of three, Lecrae adds New York Times best-selling author, entrepreneur, speaker, thought leader, philanthropist, and Co-Owner/President of Reach Records to his achievements.
While on the surface, it appeared that Lecrae was living his dream, secretly his life was spinning out of control. Ready to walk away from everything—his career, marriage, and family – Lecrae decided to finally face the traumas he had experienced, and deal with it, step by step. "The Road To Restoration is awindow into my journey towards Restoration. It's easy to think that life gets easier the more successful you get. But, the more successful I became the more I had to fight for something I couldn't maintain. It broke me, but it also opened the door for me to be restored."
The second step of The Road to Restoration: Closing The Gap (Part 2) includes Lecrae meeting his father. "For the first time in my life I got to sit down and talk to my father face to face and I went through so many emotions seeing him but I'm thankful that I finally got to ask him all the questions I never got to ask. It was healing and now he texts me almost everyday!" The Road to Restoration: This Is Not The End (Part 3) shows how Lecrae is restoring his own family and the steps he's taken to prioritize them. "I used to be a creative who was taking time for the family but now I'm a family man who is fighting to stay creative," shares Lecrae! "Just being a young black man who was fatherless, lived in a disenfranchised community, I've been restored to understanding that my worth, my value is not predicated by where I came from, or what's happened to me. I've been made whole through spiritual restoration, through my faith in God, through therapy and and recognize that I have infinite purpose and worth."
"Restoration is ongoing… an endless pursuit towards accepting what God has for you and trusting Him to lead you to what's ahead," shares Lecrae. "It is the key essential for life. As painful as the things I've gone through, as painful as the things you've gone through, none of it is beyond restoration."The Road To Restoration video series also features appearances from: NBA All Star player Steph Curry, former NBA player Jeremy Lin, music industry executive & "Silence The Shame" mental health advocate, Shanti Das, Reach Records artists Tedashii, Grammy-award winning songwriter Natalie Lauren Sims, Pastor Leonce Crump and more.
Please continue on the journey and watch Lecrae's the three part video series, The Road To Restoration below and pre-order the album Restoration and book I Am Restored: How I Lost My Religion But Gained My Faith" today! The album features artists across all genres including John Legend, Kirk Franklin, YK Osiris, Jozzy, Dani Leigh, Marc E. Bassy, BJ The Chicago Kid and more. The first single "Set Me Free,"features YK Osiris (produced by GAWVI) and was followed up by "Deep End," (produced by Anthony Gardner), "Drown" ft. John Legend (producers Danny Majic, DJ Frank E, and Ace Harris) and "Zombie."
InKingsmen Media, lecrae, road to Reatoration, youtube video
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text:
/*
 * Licensed under the Apache License, Version 2.0 (the "License");
 * you may not use this file except in compliance with the License.
 * You may obtain a copy of the License at
 *
 *      http://www.apache.org/licenses/LICENSE-2.0
 *
 * Unless required by applicable law or agreed to in writing, software
 * distributed under the License is distributed on an "AS IS" BASIS,
 * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 * See the License for the specific language governing permissions and
 * limitations under the License.
 */
package org.apache.aries.subsystem.core.archive;

import java.util.Collection;
import java.util.Collections;
import java.util.HashSet;
import java.util.Set;

public abstract class AbstractClauseBasedHeader<C extends Clause> implements Header<C> {
	public interface ClauseFactory<C> {
		public C newInstance(String clause);
	}

    protected final Set<C> clauses;

    public AbstractClauseBasedHeader(Collection<C> clauses) {
        if (clauses.isEmpty()) {
            throw new IllegalArgumentException(String.format(
                    "The header %s must have at least one clause.", getName()));
        }
        this.clauses = Collections.synchronizedSet(new HashSet<C>(clauses));
    }

    public AbstractClauseBasedHeader(String header, ClauseFactory<C> factory) {
    	Collection<String> clauseStrs = new ClauseTokenizer(header).getClauses();
		Set<C> clauses = new HashSet<C>(clauseStrs.size());
		for (String clause : new ClauseTokenizer(header).getClauses()) {
			clauses.add(factory.newInstance(clause));
		}
		this.clauses = Collections.synchronizedSet(clauses);
    }

    @Override
    public final Collection<C> getClauses() {
        return Collections.unmodifiableCollection(clauses);
    }

    @Override
    public int hashCode() {
        int result = 17;
        result = 31 * result + getName().hashCode();
        result = 31 * result + clauses.hashCode();
        return result;
    }

    @Override
    public boolean equals(Object o) {
    	if (o == this) {
    		return true;
    	}
    	if (!(o instanceof AbstractClauseBasedHeader)) {
    		return false;
    	}
    	AbstractClauseBasedHeader<?> that = (AbstractClauseBasedHeader<?>)o;
    	return that.getName().equals(this.getName())
    			&& that.clauses.equals(this.clauses);
    }

    @Override
    public String toString() {
        StringBuilder builder = new StringBuilder();
        for (C clause : getClauses()) {
            builder.append(clause).append(',');
        }
        // Remove the trailing comma. Note at least one clause is guaranteed to
        // exist.
        builder.deleteCharAt(builder.length() - 1);
        return builder.toString();
    }
}


This unique feature in Walloon is ideal for discovering a fascinating Aquatic World: a "Sharks and Coral Reef" room and "World Aquatic Biodiversity" room. A total of 46 tanks in natural surroundings, 2,500 resident creatures, 155,000 litres of seawater and fresh water, and a 66,000-litre tank just for sharks. Experience a real dive without getting your feet wet and discover the fauna of seas, lakes and rivers from all over the world. The Zoological Museum traces the evolution of world fauna, from the sponge to the whale: more than 20,000 specimens, including a room devoted to Belgian fauna.


Think Mediterranean and you're sailing in blue skies and blue seas, dipping bread into olive oil and sipping red wine. Think Mediterranean diet and remember this acronym – PREDIMED.
After eight years and over 60 published research papers this study has uncovered many interesting facts about the Mediterranean Diet. Most important however is that the study was ceased ahead of schedule as the results were so surprising the researchers could not ethically allow the control group to continue and not reap the benefits of eating nuts and using extra virgin olive oil.
In a nut shell …..the PREDIMED diet shows that although nuts are high in fat and energy we should all be including a 30g handful of mixed nuts each day as part of a healthy Mediterranean diet. This diet should also include: extra virgin olive oil, fruit, vegetables, legumes, wholegrains, fish, lean meat and reduced fat dairy. Together they help reduce the risk of heart disease and diabetes and most surprising of all play a role in weight management. Eating small regular amounts of plant foods rich in healthy fats is not "fattening". It's time to bust the myth and move beyond the low fat diet to a healthy fat diet for weight management.
 Protocol, PREDIMED Research. Available at https://predimed.onmedic.net/LinkClick.aspx?fileticket=PPjQkaJqs20%3d&tabid=574.
 Ibarrola-Jurado N et al Cross-Sectional Assessment of Nut Consumption and Obesity, Metabolic Syndrome and Other Cardiometabolic Risk Factors: The PREDIMED Study. PLoS One. 2013;8(2):e57367.
 Estruch R et al Primary Prevention of Cardiovascular Disease with a Mediterranean Diet. N Engl J Med.2013;368(14):1279-1290.
 Casas-Agustench P, et al. Cross-sectional association of nut intake with adiposity in a Mediterranean population. Nutr Metab Cardiovasc Dis. 2011;21(7):518-25.
 Zamora-Ros R, et al. High urinary levels of resveratrol metabolites are associated with a redcution in he prevalence of cardiovascular risk facors in high risk patients. Pharmacol Res. 2012;65(6):615-20.


2018 Acura Crv – 2018 acura crv, A lot of people get car as a annoying task. While driving a vehicle a brand new car is entertaining, generating the decision of what one to buy calls for analysis, efforts and study. If you make use of this info, the entire approach of getting a car will be exciting instead of challenging. You can literally preserve a great deal of funds by undertaking online analysis. When you see the car you want, you may go to the seller straight or have a community car dealership provide the car to you. Attempt likely to save more cash if the true dealer providing the car is fairly nearby.
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If you could get the financing ahead of your obtain, contact the bank to view. This helps to ensure that is good for your stability. Typically the dealership's finance office will find a far better amount for you than a bank, but it really is a very good idea to understand what monthly interest you are checking out before shopping.


Penn & Teller´s live show has been a hit on Broadway and around the country and now has a permanent home in Las Vegas here at the Rio All-Suite Hotel & Casino.
Known as the "Bad Boys of Magic," for supposedly revealing the secrets to their tricks, they may show you how it´s done, but they still manage to leave you startled.
Penn & Teller´s hilarious and outrageous appearances on their own Emmy-winning shows as well as "The Late Show with David Letterman," "The Tonight Show with Jay Leno" and "Hollywood Squares" had Entertainment Weekly call them two of the funniest comedians alive today.