text:
Was Jack the Ripper a Polish Jewish immigrant?
For more than a century, the identity of Jack the Ripper, the brutal murderer who stalked the Whitechapel area of Victorian London, UK has been a mystery. But now DNA evidence reportedly points to a Polish Jewish immigrant named Aaron Kosminski, who spent his final decades locked up in a lunatic asylum.
According to British media reports, a shawl recovered from the scene of the murder of Catherine Eddowes was found to contain DNA of the victim and of Kosminski, who had been named at the time as a suspect in the murders. The DNA in the shawl was analysed by Dr. Jari Louhelainen, who the Daily Mail called a Finnish "world renowned expert in historical crime scenes."
Louhelainen was reportedly called in by the British owner of the garment, which was purchased at auction in 2007. The DNA on the shawl was crosschecked with that of Kosminski's descendants, reports said. Kosminski died in 1919 in an asylum, where he had been institutionalized since 1891.
The identity of Jack the Ripper has been the subject of much speculation throughout the years. The murderer is believed to have been responsible for the deaths of at least five prostitutes in the British capital in 1888. Other candidates touted for the murders included a grandson of Queen Victoria, a painter, a duke and even a former British prime minister. For over a century the identity of notorious serial killer Jack the Ripper has baffled criminologists.
Jack the Ripper is the best known name given to the unidentified serial killer active in the largely impoverished areas in and around the Whitechapel district of London in 1888.
The name originated in a letter written by someone claiming to be the murderer that was widely disseminated in the media. The letter is widely believed to have been a hoax, and may have been written by a journalist in a deliberate attempt to heighten interest in the story. Within the crime case files as well as journalistic accounts the killer was known as "the Whitechapel Murderer" as well as "Leather Apron".
20 Jewish Times Asia September 2014 Is supporting Hamas anti-Semitic?
Indeed, many Israelis are critical of some of their nation's policies, but support for Hamas is anti-Semitic, because Hamas's policies and actions are based, at their core, on Jewishhatred.
Criticising specific Israeli policies both amongst local citizens and the wider Jewish population is certainly not intrinsically anti-Semitic. Yet many prominent individuals, some out of ignorance, many more with full knowledge of what they are doing, are overtly supporting Hamas.
Some have even praised it. Others, like Italy's most famous philosopher, Gianni Vattimo, are trying to raise money and provide material support to this anti-Semitic terrorist organisation. Still others refuse to condemn it, while condemning Israel in the strongest terms.
Here is part of what the Hamas Charter, which continues to articulate its governing principles, says about Jews: "The enemies have been scheming for a long time. [Their] wealth [permitted them to] take over control of the world media such as news agencies, the press, publication houses, broadcasting and the like. [They also used this] wealth to stir revolutions in various parts of the globe... They stood behind the French and the Communist Revolutions... They also used the money to establish clandestine organisations which are spreading around the world, in order to destroy societies and carry out Zionist interests.
Such organisations are: the Freemasons, Rotary Clubs, Lions Clubs, B'nai B'rit and the like. All of them are destructive spying organisations... [They] stood behind WWI, so as to wipe out the Islamic Caliphate... They obtained the Balfour Declaration and established the League of Nations in order to rule the world by means of that organisation. They also stood behind World War II.... They inspired the establishment of the United Nations and the Security Council to replace the League of Nations, in order to rule the world by their intermediary. There was no war that broke out anywhere without their fingerprints on it."
A 3,300 year old coffin exposed in Jezreel Valley
During a recent salvage excavation in the Jezreel Valley, the Israel Antiquities Authority has uncovered part of a burial site dating to the Late Bronze Age (thirteenth century BCE) at the foot of Tel Shadud.
According to the excavation directors, Dr. Edwin van den Brink, Dan Kirzner and Dr. Ron Be'eri of the Israel Antiquities Authority, "During the excavation we discovered a unique and rare find: a cylindrical clay coffin with an anthropoidal lid (a cover fashioned in the image of a person) surrounded by a variety of pottery consisting mainly of storage vessels for food, tableware, cultic vessels and animal bones. As was the custom, it seems these were used as offerings for the gods, and were also meant to provide the dead with sustenance in the afterlife."
The skeleton of an adult was found inside the clay coffin and next to it were buried pottery, a bronze dagger, bronze bowl and hammered pieces of bronze. "Since the vessels interred with the individual were produced locally", the researchers say, "We assume the deceased was an official of Canaanite origin who was engaged in the service of the Egyptian government".
Another possibility is that the coffin belonged to a wealthy individual who imitated Egyptian funerary customs. The researchers add that so far only several anthropoidal coffins have been uncovered in the country. The last ones discovered were found at Deir el-Balah some fifty years ago. According to the archaeologists, "An ordinary person could not afford the purchase of such a coffin. It is obvious the deceased was a member of the local elite".
The graves of two men and two women who may have been members of his family were also located near the coffin. The discovery of the coffin at Tel Shadud is evidence of Egyptian control of the Jezreel Valley in the Late Bronze Age.
During the period when the pharaohs governed the country, Egyptian culture greatly influenced the local Canaanite upper class. Signs of Egyptian influence are occasionally discovered in different regions and this time they were revealed at Tel Shadud and in the special tomb of the wealthy Canaanite. A rare artifact that was found next to the skeleton is an Egyptian scarab seal, encased in gold and affixed to a ring. The scarab was used to seal documents and objects.
Pope Francis makes landmark visit to Israel
Excavations from the Hasmonean period discovered
Art Basel in Hong Kong: What to know before you go
Yad Vashem receives rare Purim manuscript
President Peres receives Spirit of Davos award
Guinness World Record achieved for lowest altitude formation flight over The Dead Sea
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NS_SWIFT_NAME(AppEventsState)
@interface FBSDKAppEventsState : NSObject<NSCopying, NSSecureCoding>

@property (nonatomic, readonly, copy) NSArray *events;
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- (instancetype)init NS_UNAVAILABLE;
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- (void)addEvent:(NSDictionary *)eventDictionary isImplicit:(BOOL)isImplicit;
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@end

redpajama_set_name: RedPajamaGithub


text:
Sustainable Waterfront & Downtown Master Plan
The City of Nelson has developed a Sustainable Waterfront and Downtown Master Plan.
The City of Nelson has created a Sustainable Waterfront and Downtown Master Plan to guide future development and redevelopment in the downtown and waterfront areas. The Sustainable Waterfront and Downtown Master Plan draws on the goals and objectives established in the City of Nelson's Path to 2040 Sustainability Strategy created through a collaborative approach between the City and community members.
The downtown is the commercial and cultural centre of Nelson and is considered the 'heart' of the community. The downtown offers a mixture of uses such as: retail, accommodation, restaurants, office space, arts, culture facilities, and housing. This mixture of uses helps establish a more diverse, thriving community of people. The walkability of the downtown allows for stronger community connections and provides a small town feel.
The waterfront is the natural gem of the city, and offers great potential and opportunity for the future growth of the community. The waterfront spans from the northwestern edge of the city from the CPR lands to Red Sands Beach, a total length of 4.8 Kilometers. This area is largely comprised of light industrial, heavy industrial, CPR lands, commercial, the municipal airport and open/park space. The waterfront area also includes approximately 81 hectares of the north shore waterfront, located at the north end of the Big Orange Bridge.
Purpose of Master Plan
The purpose of the Sustainable Waterfront and Downtown Master Plan is to find a way to better connect and revitalize these two fundamental areas of the community. The plan aims to embody the principles of sustainability and will guide future development of the downtown and waterfront areas. This project has been completed through an open and collaborative process with the community. Project Objectives include:
Creating a clear and concise plan that follows the principles of thePath to 2040 Sustainability Strategy
Identifying and designing appropriate gateways to the downtown and to the waterfront
Identifying areas of public interest on the waterfront (i.e. parks, open spaces, plazas, public access and view corridors)
Creating design guidelines that direct development in both the private and public realm
Preserving and building upon Nelson's character and create opportunities for revitalization
Identifying locations for appropriate land uses
Establishing an efficient flow of people to and from the waterfront and downtown
Ensuring a comprehensive and integrated approach for future development and redevelopment
Development Services & Engineering
Contact Development Services & Engineering
Sustainable Waterfront and Downtown Master Plan (PDF)
Nelson Next (Climate Action Plan)
Corporate Greenhouse Gas Reduction Plan
Low Carbon Path to 2040: Community Energy
Path to 2040 Sustainability Strategy
Sustainability Leadership Awards
Water Masterplan
What You Can Do?
Plastic-Free Nelson

redpajama_set_name: RedPajamaCommonCrawl


Kvatch Rebuilt had a new release fairly recently too.
Yeah, a few weeks back, no? I guess there were some weather related changes.
Not really, but I reviewed the patch to see if it needed changing and I found some stuff in the patch that shouldn't be there, so voila!
Good stuff altogether, AB. I can't play Oblivion without either AN or KR, so I likey.
AB, let me clarify; please excuse my slowness. There were no changes to the resources in 1.38, yes? I'm wondering if I need to re-PyFFI my meshes and re-optimize my textures, etc., or if I can just drag and drop the ESPs I use?
No, I didn't touch the resources.
Great! 'Tis what I was thinking, good to go.
hey so just spent 3 dys trying to get a bunch of mods working, however apparently this mod causes my game to crash when i try to enter the Imperial City. and ONLY then.
Idk why this is causing this but its a really annoying problem since this adds alot of beauty to the game and with teh awesome interior mods.
Have you sorted your load order with BOSS and created a Bashed Patch? Sort your load order first and then create a Bashed Patch.
If you don't absolutely need Pluggy, get rid of it--it's buggy and causes CTDs. Base All Natural is quite stable when installed properly. I've been running it for years without a single issue caused by it that I can recall.
Yes i have. Not sure why it crashes, was working before i reinstalled oblivion as well. and its just that mod, uninstalled everything else. gonna try a new one in a few min.
Found a soloution to my issue.
AN didn't corrupt your save. Saved game files do get corrupted though, especially if you use auto-save. I recommend disabling all auto-saves. Be careful with using quick saves as well. They are also prone to corruption.
What's buggy about Pluggy. Just curious- does it adversely affect anything in particular?
It does cause crashes. That's been a well known fact for a while. I only load it as long as I need it.
Whenever that happen in my game I always repair the gamesave in WB by clicking on Remove Bloat and Repair Abomb for a selected gamesave in the Saves tab. Which has worked for me so far.
No, The MOD corrupted the save. as its only what made me crash when i had it activated.
Its even explained in the description that it does corrupt save files if you dont save outside a city somewhere save.
no idea that was a thing, gonna try that thansk!
@Schtearn I'm not sure about specifics, but it causes general instability. This is from stuff I've read and my first hand experience. Running Pluggy really increased my CTDs back in the day. But hey, if you run Pluggy with no issues, good on ya. Definitely was not the case for me.


text:
Justice League Script Done - But Will It Get Made?
– on Jun 14, 2007
A Justice League script has been turned in to Warner Bros. which was written by Kieran and Michele Mulroney (each of whose IMDB stats show virtually no track record as screenwriters). Supposedly the script is so good that WB is shopping around for a director.
Is a Justice League movie going to make it to theaters before your 5 year old graduates college? I wouldn't be on it.
The budget would be monstrous, it would need quite a large ensemble cast where most of the characters would no doubt be marginalized due to the limits of the length of the movie, plus could you get Christian Bale and Brandon Routh available at the same time and willing to put on their respective costumes for this type of movie?
It may happen eventually, but the odds are stacked against it in my opinion. That's not to say that I wouldn't want to see it, of course. Actually over at Cinematical a suggestion was made that they should dump the live-action idea and instead make a big-screen animated CGI version. Now THAT would be cool and a lot more likely to be made sooner, if at all.
Source: Cinematical
Tags: justice league
Why Avengers: Infinity War Cut Thor Fighting A Serpent
Craig Elvy


'Goodland' Apple is a large green apple with a red blush. Expect a crisp apple for eating, cooking or juicing. As with all apple trees, must have another (different) apple or crabapple tree within 500′ for cross pollination to occur.


Timberframe Island Escape is a cottage located in Sober Island. Nestled among one of Nova Scotia's prime lobster fishing communities on Sober Island, you will find total luxury for your family and friends in this amazing timberframe home on 5 very private acres along the Atlantic coast.
Nearby restaurants include Dufferin Variety & Pizza.
The information displayed here is displayed 'as is'. Also check the website ( if listed ) for up-to-date information, prices and availability. Stay Canada is not responsible for the content of external websites. If you are the owner or operator of Timberframe Island Escape and wish to update or modify the content on this page including room details, specials and getaways or availability, please use our submission page.
Any prices displayed for Timberframe Island Escape should be used as a guide only and may vary with room and dates chosen. Lower pricing may be available via the booking system if available. Not all properties are available for online booking. Please note all distances shown are approximate, and may not reflect driving or travel distances.


This morning was Phil Windley's monthly CTO breakfast / forum. I don't make it to these as often as I'd like (and I wasn't able to stay for the whole thing today), but they're always interesting when I do get to go.
Phil Burns has been working from home for a long time now, and can often go for a week without driving a car or seeing anyone outside his family. That works for getting a lot of work done, and events like this one help provide social input. Instant messaging, Skype and Twitter also.
Several people work remotely and have team interaction via some combination of IRC, instant messaging and Skype. Indeed, sometimes those tools facilitate conversation even between co-workers in the same room.
Phil talked about his recent experience converting a physical machine to a virtual machine. I suspect that in some cases that may be easier to do than setting up a virtual machine from scratch, and I may try it for a project I'm working on (I'm trying to set up GnuCash, and it won't compile nicely on my Powerbook just now, so I'm thinking of setting it up in a virtual FreeBSD machine).
Scott Lemon mentioned getting some older G3 iMacs, and is looking for free software that his son might enjoy. I'll note that my daughter (close to the same age, I believe) also has a G3 iMac, and her very favorite program is Tux Paint. Sometime in the not too distant future I may also try throwing one of the free Logo interpreters on there and see if she takes to that. Scott also talked about getting the old DOS version of Warcraft II running in DOSBox.


We all know of Google, Yahoo, MSN, Bing, Facebook, Twitter, Yelp, YouTube, CitySearch, TripAdvisor, and so many a lot more. SEM is the administration of all of these Search Engines and Directories to insure all your company's facts is branded, relevant, right, and has an exclusive eye appeal to entice prospects. In other words world wide web presence optimization.
SEM is also the management of business's on the net standing, which consists of ratings, reviews, mentions, tweets, and feedback. One negative evaluate could ship an enterprise to the bottom of a preferred search term for their industry, or even a low rating may possibly ship a prospect to hit the back button and call a competitor. On the other hand, a fantastic comment on Twitter may perhaps deliver you 100′s of new buyers like word of mouth and this is why search engine marketing is so important.
When selecting an SEM firm to manage your web marketing and online net existence wants be certain of the following.
Search Engine Marketing is on the internet advertising, web presence optimization and repute management of an organization to be able to appeal to new prospects and raise profits. As a result, no matter whether you might be smaller business enterprise needing local marketing or perhaps a huge corporation with national goals your reputation is your business enterprise. Look to an expert Repute Management corporation to engage your market and manage your world wide web existence optimization for maximum profitability.
Learn the real way to on the internet wealth with Income Automation System and turn out to be enlightened to how you can use the Net to earn income. Take a look at Income Automation System Now!


Built in 1844 by Virginia native John Glascock (1817-1897), this house is one of three remaining examples in Tuscaloosa of the Gothic Revival style and one of only approximately three dozen antebellum buildings left in Tuscaloosa. It features handsome cutwork and pointed arch windows, as well as original interior details. Glascock was a cousin of statesman and unsuccessful presidential candidate Henry Clay, who reputedly stayed in the house on several occasions. The area is primarily commercial, and the house would make an excellent potential rehabilitation tax credit project. To date, it has been on the market for over a year with no offer.


Introducing young children to clay is so much fun.
We discussed how to create flat shapes, coils and textures.
The students had the choice to create people or an abstract composition.
We used acrylic paint to decorate our artwork.
Student comment: "This looks like my father; he has a big nose."
Student comment: "I am a ballerina."
The broken pieces taught us the art of restoration.
Student comment: "I kicked the ball."
Really a beautiful compositions, lovely. Very expressives. I like those colors.
The work is absolutely stunning...a joy to behold.
Very beautifull!!! Bravo little angels!!!
It's nice, very nice to find blogs like this one. I think I've checked it all, and I must express my admiration for this awsome work that has been done with kids. I experienced this strange need to go running and giving life to all sort of ideas that came up with, by taking a look at this beautiful art. I think I'll start using more different materials... got tempted. I saw also the peaceful and free look in the eyes of your children... it means a lot... they've enjoyed it all. (I was wondering what's the music that joins the welcome video?) Well, congratulations for your job.
These are amazing pieces! I love the variety that each piece has. Well done, they are a credit to your teaching and the children who made them!


A houseboy chained and locked up in cage with goats in Lagos for days by a wicked Nigerian man, is currently trending across social media. It's not known yet what the boy did to have received this type of barbaric treatment but it hasn't gone down well with social media users.
Nollywood Actress Eucharia Anunobi Comes For Big Church Ministry That Sent Assistant Pastor To Her Village To PROVE HIS MINISTRY Without Any Financial Assistance "You Are Free To Block Me After This Post... You won't give them $1 but you will expect tithe from them in a matter of months"
Wow! You'll Love These Monalisa Chinda Photos… Check Them Out!


text:
Dr Callum Livingstone
Honorary Senior Clinical Lecturer
C.Livingstone@surrey.ac.uk
18 AY 04
Dr Livingstone was appointed as Consultant Chemical Pathologist/Senior Lecturer in 2001. He is deputy director of Guildford Peptide Hormones Supraregional Assay Service (SAS) located in the Clinical Laboratory, Royal Surrey County Hospital. Clinical interests include lipidology and clinical nutrition.
Specialist Registrar in Chemical PathologyNewcastle-upon-Tyne University Hospitals NHS Trust.April 1996-April 2001.
MRC post-doctoral researcherGlucose Transport Group, Biochemistry Department, Glasgow University.April 1993-April 1996.
PhD studentMolecular Pharmacology Group, Biochemistry Department, Glasgow University.October 1989-April 1993.Thesis title: 'Interactions between insulin and adenlyl cylase signalling.'
SHO in PathologyRoyal Gwent Hospital, Newport.February 1989-August 1989.(Duties in Clinical Haematology, Clinical Biochemistry and Histopathology)
SHO in MedicineRoyal Gwent Hospital, Newport.August 1988-February 1989.(3 months General Medicine/Cardiology and 3 months Geriatric Medicine)
JHO in General MedicineCrosshouse Hospital, Kilmarnock.February 1988-August 1988.
JHO in General SurgeryCrosshouse Hospital, Kilmarnock.August 1987-February 1988.
Insulin resistance, insulin-like growth factors and clinical nutrition.
Departmental duties
Module organiser, HCSMOO8, MSc Health and Clinical SciencesModule organiser, BMSM010, MSc Nutritional MedicineChairman of Board of Studies, MSc Health and Clinical Sciences
Livingstone C. Insulin-like growth factor-I and clinical nutrition. Clin Sci 2013; 125: 265-280.
Livingstone C. IGF2 and cancer. Endo Rel Canc 2013; 20: R321-R339
Livingstone C, Borai A. IGF-II: its role in physiology and metabolic disease. Clin Endocrinol 2014; 80: 773-781.
Walsh J, Karanjia ND, Taylor A, Livingstone C. Selenium status in patients receiving short term parenteral nutrition: frequency of deficiency and response to a standard supplementation regimen. ISRN Pathology 2013 http://dx.doi.org/10.1155/2013/604954
Borai A, Livingstone C, Heald AH, Ferns G. Delta insulin-like growth factor binding protein-1 (IGFBP-1): A measure of hepatic insulin resistance? Ann Clin Biochem 2013; 51: 269-276.
Borai A, Bahijri S, Livingstone C, Nawajka, Bawazeer A, Baarmah Z, Shanaa A, Kadam I, Abdelaal M, Assessment of the use of Becton Dickinson plain and serum separator tubes in measurement of 25-hydroxyvitamin D3 (25OHD3) by HPLC and immunoassay methods. J Clin Lab Anal 2014
Conference papersHamilton J, Wark G, Livingstone C. An investigation into the clinical utility of serum IGF-I and IGFBP-3 measurement in adult patients receiving parenteral nutrition.EuroLabFocus, Liverpool, Oct 2014.
C Livingstone (2007)Protein markers of nutritional status, In: CPD Bulletin Clinical Biochemistry8(3)pp. 67-75
A number of protein-energy markers are currently available whose measurement is a useful adjunct to clinical nutritional assessment. These include transferrin (Tf), prealbumin and retinol binding protein (RBP). Other nutritional markers of recognised value but not currently in widespread use are insulin-like growth factor-I (IGF-I) and leptin. Currently no single marker can assess overall nutritional status but their levels may be of value of in providing information on metabolic status ie catabolism or anabolism, determining prognosis, and in monitoring of nutrition support. All have limitations in that their serum levels can be altered by factors other than the patient's nutritional status, most importantly the acute phase response. Clinicians requesting measurement of these proteins need to be mindful of any confounding factors when interpreting results. Levels should be interpreted along with clinical findings and the results of other investigations including an inflammatory marker such as C-reactive protein (CRP). © 2007 Rila Publications Ltd.
C Livingstone (2015)Manganese and Parenteral Nutrition, In: Complete Nutrition15(6)pp. 26-28 Complete Media & Marketing Limited (CM2)
Manganese (Mn) is an essential dietary micronutrient. It is an integral component of various enzymes required for the synthesis of glycosaminoglycans and glycoproteins, which are the key components of connective tissue. Mn also activates prolidase, making proline available for the synthesis of collagen. Together these processes are required for tissue maintenance and wound healing. Mn is also required for energy metabolism, in particular for ATP synthesis. It is a cofactor for various mitochondrial enzymes, including superoxide dismutase, which metabolises superoxide generated during oxygen consumption. These roles of Mn are essential for normal functioning of various organ systems and of the immune system. Whilst Mn deficiency is very rare in patients receiving parenteral nutrition (PN), Mn toxicity is a relatively common complication
A Borai, C Livingstone, S Mehta, H Zarif, F Abdelaal, G Ferns (2009)Biological variation in fasting serum insulin-like growth factor binding protein-1 (IGFBP-1) among individuals with a varying glucose tolerance, In: CLINICAL BIOCHEMISTRY42(12)pp. 1270-1274 PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.clinbiochem.2009.05.005
M Ghayour-Mobarhan, A Taylor, SMR Kazemi-Bajestani, S Lanham-New, DJ Lamb, N Vaidya, C Livingstone, T Wang, GAA Ferns (2008)Serum Zinc and Copper Status in Dyslipidaemic Patients with and without Established Coronary Artery Disease, In: CLINICAL LABORATORY54(9-10)pp. 321-329 CLIN LAB PUBL
C Livingstone, J Davis (2007)Targeting therapeutics against glutathione depletion in diabetes and its complications, In: British Journal of Diabetes and Vascular Disease7(6)pp. 258-265
DOI: 10.1177/14746514070070060201
Glutathione (GSH) is the most abundant intracellular antioxidant, the dysregulation of which is widely implicated in disease states. There is in vitro and clinical evidence that abnormal glutathione status is involved in β-cell dysfunction and in the pathogenesis of long-term complications of diabetes. Interest has developed in the potential for therapeutic modification of glutathione status in the treatment of diabetes. There is evidence which supports the use of glutathione pro-drugs, lipoic acid and vitamin supplementation but further studies are required before these enter widespread use. Studies into the role of oxidative stress in diabetes rely heavily on the ability to measure glutathione, which has been a problematic analyte to measure in the laboratory. New electrochemical methods being developed should speed up the rate at which data can be accumulated and will help define clinical utility for its measurement.
C Livingstone (2013)Insulin-like growth factor-I (IGF-I) and clinical nutrition, In: Clinical Science125(6)pp. 265-280
DOI: 10.1042/CS20120663
IGF-I (insulin-like growth factor-I) is a peptide hormone, produced predominantly by the liver in response to pituitary GH (growth hormone), which is involved in a wide variety of physiological processes. It acts in an endocrine, paracrine and autocrine manner to promote growth. The production of IGF-I signals the availability of nutrients needed for its anabolic actions. Recently, there has been growing interest in its role in health and disease. IGF-I has long been known to be regulated by nutrition and dysregulated in states of under- and over-nutrition, its serum concentrations falling in malnutrition and responding promptly to refeeding. This has led to interest in its utility as a nutritional biomarker. A considerable evidence base supports utility for measurement of IGF-I in nutritional contexts. Its concentration may be valuable in providing information on nutritional status, prognosis and in monitoring nutritional support. However, it is insufficiently specific for use as a screening test for under nutrition as its serum concentration is influenced by many factors other than nutritional status, notably the APR (acute-phase response) and endocrine conditions. Concentrations should be interpreted along with clinical findings and the results of other investigations such as CRP (C-reactive protein). More recently, there has been interest in free IGF-I which holds promise as a nutritional marker. The present review covers nutritional regulation of IGF-I and its dysregulation in disease, then goes on to review recent studies supporting its utility as a nutritional marker in clinical contexts. Although not currently recommended by clinical guidelines, it is likely that, in time, measurement of IGF-I will become a routine part of nutritional assessment in a number of these contexts.
A Borai, C Livingstone, H Zarif, S Mehta, M Kholeif, M Abdelaal, H Al-Ghamdi, G Ferns (2009)A comparative study of insulin resistance for Saudi and Caucasian subjects across a range of glycaemic categories, In: Diabetes and Metabolic Syndrome: Clinical Research and Reviews3(4)pp. 204-210
DOI: 10.1016/j.dsx.2009.07.013
Aim: Saudi and Caucasian subjects, matched for adiposity, and of differing glycaemic status were compared using several insulin sensitivity indices and to also to assess insulin, glucose and insulin-like growth factor binding protein-1 (IGFBP-1) responses to intravenous glucose. Methods: Subjects with normal glucose tolerance (NGT; n = 24), impaired fasting glucose (IFG; n = 12), impaired glucose tolerance (IGT; n = 12), and type 2 diabetes (DM; n = 13) were recruited from Saudi (n = 33) and Caucasian (n = 28) populations. All had specimens taken in the context of a standard oral glucose tolerance test at their first visit and had the insulin sensitivity parameter (Si) determined by frequently-sampled intravenous glucose tolerance test (FSIVGTT) at a second visit. Results: Saudis in the NGT and pooled glucose intolerance categories had significantly higher diastolic blood pressure (p < 0.001, p < 0.05 respectively) and HbA1c (p < 0.01, p < 0.05 respectively) compared to Caucasians. Caucasians in the NGT category had significantly higher Si, fasting and 2 h IGFBP-1 (p < 0.01, p < 0.05 and p < 0.01 respectively) compared to Saudis. Two hours following oral or intravenous glucose serum IGFBP-1 decreased to 44% (p < 0.001) and 50% (p < 0.05) of baseline levels respectively. Conclusions: Our data suggest that adult Saudis with normal glucose tolerance appear to be more insulin resistant than Caucasians matched for adiposity. In normal individuals at 2 h the IGFBP-1 level will be about half the baseline level regardless of the route of glucose administration. © 2009 Diabetes India.
C Livingstone (2015)Zinc: physiology, deficiency, and parenteral nutrition., In: Nutrition in Clinical Practice30(3)pp. 371-382
The essential trace element zinc (Zn) has a large number of physiologic roles, in particular being required for growth and functioning of the immune system. Adaptive mechanisms enable the body to maintain normal total body Zn status over a wide range of intakes, but deficiency can occur because of reduced absorption or increased gastrointestinal losses. Deficiency impairs physiologic processes, leading to clinical consequences that include failure to thrive, skin rash, and impaired wound healing. Mild deficiency that is not clinically overt may still cause nonspecific consequences, such as susceptibility to infection and poor growth. The plasma Zn concentration has poor sensitivity and specificity as a test of deficiency. Consequently, diagnosis of deficiency requires a combination of clinical assessment and biochemical tests. Patients receiving parenteral nutrition (PN) are susceptible to Zn deficiency and its consequences. Nutrition support teams should have a strategy for assessing Zn status and optimizing this by appropriate supplementation. Nutrition guidelines recommend generous Zn provision from the start of PN. This review covers the physiology of Zn, the consequences of its deficiency, and the assessment of its status, before discussing its role in PN.
C Livingstone (2006)Parenteral nutrition: the clinical biochemist's perspective, In: Comp Nutr6pp. 12-14
S Chahine, C Livingstone, J Davis (2006)Differentiation of plasma thiols using a centrifugally activated mercaptobenzothiazole disulphide exchange indicator, In: Chemical Communications(14)pp. 592-594
DOI: 10.1039/B612092J
J Walsh, ND Karanjia, A Taylor, C Livingstone (2013)Selenium status in patients receiving short term parenteral nutrition: frequency of deficiency and response to a standard supplementation regimen, In: ISRN Pathology2013 Hindawi Publishing Corporation
DOI: 10.1155/2013/604954
A Borai, C Livingstone, GAA Ferns (2007)The biochemical assessment of insulin resistance, In: ANNALS OF CLINICAL BIOCHEMISTRY44pp. 324-342 ROYAL SOC MEDICINE PRESS LTD
A Borai, C Livingstone, H Zarif, G Ferns (2009)Serum insulin-like growth factor binding protein-1: an improvement over other simple indices of insulin sensitivity in the assessment of subjects with normal glucose tolerance, In: ANNALS OF CLINICAL BIOCHEMISTRY46pp. 109-113 ROYAL SOC MEDICINE PRESS LTD
DOI: 10.1258/acb.2008.008160
C Livingstone (2015)Zinc and clinical nutrition, In: Comp Nutr(15)pp. 32-35
S Mehta, C Livingstone, A Borai, G Ferns (2012)Insulin-like growth factor binding protein-1 in insulin resistance and cardiovascular disease, In: British Journal of Diabetes and Vascular Disease12(1)pp. 17-25
Insulin-like growth factors (IGFs) are peptide hormones that have significant structural homology with insulin. IGF binding proteins (IGFBPs), in particular IGFBP-1, are important determinants of IGF activity such as enhancing peripheral glucose uptake, decreasing hepatic glucose output and modifying lipid metabolism. Herein factors which alter IGFBP-1 and the utility of measuring IGFBP-1 are considered as the role of IGFBP-1 is explored within the context of insulin resistance and the development of cardiovascular disease. © SAGE Publications 2012.
C Porchetta, A Borai, S Shafi, G Ferns, G Wark, C Livingstone (2012)Analytical and clinical validation of two ELISA assays for adiponectin as a marker of insulin resistance
Callum Livingstone (2017)Review of Copper Provision in the Parenteral Nutrition of Adults, In: Nutrition in Clinical Practice32(2)pp. 153-165 SAGE Publications
The essential trace element copper (Cu) is required for a range of physiologic processes, including wound healing and functioning of the immune system. The correct amount of Cu must be provided in parenteral nutrition (PN) if deficiency and toxicity are to be avoided. While provision in line with the standard recommendations should suffice for most patients, Cu requirements may be higher in patients with increased gastrointestinal losses and severe burns and lower in those with cholestasis. The tests of Cu status that are currently available for clinical use are unreliable. Serum Cu concentration is the most commonly ordered test but is insensitive to Cu deficiency and toxicity and is misleadingly increased during the acute phase response. These limitations make it difficult for prescribers to assess Cu status and to decide how much Cu to provide. There is a need for better tests of Cu status to be developed to decrease uncertainty and improve individualization of Cu dosing. More information is needed on Cu requirements in disease and Cu contamination of PN components and other intravenous fluids. New multi–trace element products should be developed that provide Cu doses in line with the 2012 American Society for Parenteral and Enteral Nutrition recommendations. This article discusses the evaluation and treatment of Cu deficiency and toxicity in patients treated with PN.
A Borai, C Livingstone, A Farzal, D Baljoon, A Al Sofyani, S Bahijri, I Kadam, K Hafiz, M Abdelaal, G Ferns (2015)Changes in metabolic indices in response to whole blood donation in male subjects with normal glucose tolerance, In: CLINICAL BIOCHEMISTRY49(1-2)pp. 51-56 PERGAMON-ELSEVIER SCIENCE LTD
Objectives Previous studies have investigated the impact of venesection upon different metabolic indices in patients with various conditions (e.g., type 2 diabetes and iron overload). We aimed to investigate the changes on different metabolic indices including glycemic, iron, lipids and inflammatory markers at different time points after blood donation in male subjects with normal glucose tolerance.Design and methods 42 male subjects were recruited to the study. Glucose tolerance was assessed by oral glucose tolerance test before (visit A) and after the blood donation (1 day, visit B; 1 week, visit C; 3 weeks, visit D; and 3 months, visit E). Fasting glucose, HbA1c, insulin, lipids, uric acid, C-reactive protein, iron stores and insulin resistance (HOMA-IR, ISI-gly) indices were measured. A repeated measures ANOVA was used for comparisons of quantitative variables between different visits. Results All subjects had normal glucose tolerance according to WHO criteria. Fasting glucose, insulin and HOMA-IR were significantly higher (~ 2%, p < 0.05; ~ 21%, p < 0.01; and ~ 11%, p < 0.05 respectively) at visit B following donation. At visit D, the mean ± SE for HbA1c (5.28 ± 0.06%) was significantly lower with a difference in percentage of ~− 3% and p < 0.05 compared to visit A (5.44 ± 0.06%). Ferritin decreased significantly at visits B, C, D and E (~− 8%, p < 0.01, ~− 24%, p < 0.001, ~− 39%, p < 0.001 and ~− 29%, p < 0.01 respectively), when compared to visit A. Conclusions At different time points after blood donation, glycemic status and iron stores are affected significantly in male blood donors with normal glucose tolerance. The changes were particularly evident three weeks after donation. Hence, the interpretation of these parameters in male blood donors needs to take this into account, and the mechanisms resulting in these effects need to be clarified.
RB Smith, C Canton, NS Lawrence, C Livingstone, J Davis (2006)Molecular anchors - mimicking metabolic processes in thiol analysis, In: NEW JOURNAL OF CHEMISTRY30(12)pp. 1718-1724 ROYAL SOC CHEMISTRY
DOI: 10.1039/b611471g
A Borai, C Livingstone, F Abdelaal, A Bawazeer, V Keti, G Ferns (2011)The relationship between glycosylated haemoglobin (HbA1c) and measures of insulin resistance across a range of glucose tolerance, In: SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION71(2)pp. 168-172 INFORMA HEALTHCARE
C McKibbin, G Wark, C Livingstone (2013)An observational study of insulin-like growth factor binding protein-2 (IGFBP-2) in patients receiving parenteral nutrition
A Borai, C Livingstone, AH Heald, Y Oyindamola, G Ferns (2014)Delta insulin-like growth factor binding protein-1 (Delta IGFBP-1): a marker of hepatic insulin resistance?, In: ANNALS OF CLINICAL BIOCHEMISTRY51(2)pp. 269-276 SAGE PUBLICATIONS INC
E Walter, S Ashley, C Livingstone, I Kemp, S Alsaffar (2016)Manganese elimination in hepatobiliary failure, In: Journal of the Intensive Care Society17(4)pp. 360-361 Sage
Anwar Borai, Callum Livingstone, Enaam Alsobhi, Abeer Al sofyani, Dalal Balgoon, Anwar Farzal, Mohammed Almohammadi, Abdulafattah Al-Amri, Suhad Bahijri, Daad Alrowaili, Wafaa Bassiuni, Ayman Saleh, Norah Alrowaili, Mohamed Abdelaal (2017)Changes in hematological indices and lymphocyte subsets in response to whole blood donation in healthy male donors, In: Scandinavian Journal of Clinical and Laboratory Investigation77(2)pp. 143-148 Taylor & Francis
Whole blood donation has immunomodulatory effects, and most of these have been observed at short intervals following blood donation. This study aimed to investigate the impact of whole blood donation on lymphocyte subsets over a typical inter-donation interval. Healthy male subjects were recruited to study changes in complete blood count (CBC) (n = 42) and lymphocyte subsets (n = 16) before and at four intervals up to 106 days following blood donation. Repeated measures ANOVA were used to compare quantitative variables between different visits. Following blood donation, changes in CBC and erythropoietin were as expected. The neutrophil count increased by 11.3% at 8 days (p
A Borai, C Livingstone, AH Heald, G Ferns (2013)Delta insulin-like growth factor binding protein-1 (IGFBP-1): A measure of hepatic insulin resistance?
VA Marvin, D Brown, J Portlock, C Livingstone (2008)Factors contributing to the development of hypophosphataemia when refeeding using parenteral nutrition, In: PHARMACY WORLD & SCIENCE30(4)pp. 329-335 SPRINGER
JSN Dutt, MF Cardosi, S Wilkins, C Livingstone, J Davis (2006)Characterisation of carbon fibre composites for decentralised biomedical testing, In: MATERIALS CHEMISTRY AND PHYSICS97(2-3)pp. 267-272 ELSEVIER SCIENCE SA
DOI: 10.1016/j.matchemphys.2005.08.021
C Mayne, C McKibbin, L Parkinson, A Armstrong, C Livingstone, G Wark (2015)Identification of therapeutic insulin-analogues in human serum by insulin immunocapture LC-MS/MS in a district general hospital
A Isaac, C Livingstone, AJ Wain, RG Compton, J Davis (2006)Electroanalytical methods for the determination of sulfite in food and beverages, In: TRAC-TRENDS IN ANALYTICAL CHEMISTRY25(6)pp. 589-598 ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.trac.2006.04.001
A Borai, C Livingstone, I Kaddam, G Ferns (2011)Selection of the appropriate method for the assessment of insulin resistance., In: BMC Medical Research Methodology11pp. 158-158 BioMed Central
DOI: 10.1186/1471-2288-11-158
Insulin resistance is one of the major aggravating factors for metabolic syndrome. There are many methods available for estimation of insulin resistance which range from complex techniques down to simple indices. For all methods of assessing insulin resistance it is essential that their validity and reliability is established before using them as investigations. The reference techniques of hyperinsulinaemic euglycaemic clamp and its alternative the frequently sampled intravenous glucose tolerance test are the most reliable methods available for estimating insulin resistance. However, many simple methods, from which indices can be derived, have been assessed and validated e.g. homeostasis model assessment (HOMA), quantitative insulin sensitivity check index (QUICKI). Given the increasing number of simple indices of IR it may be difficult for clinicians and researchers to select the most appropriate index for their studies. This review therefore provides guidelines and advices which must be considered before proceeding with a study.
A Borai, C Livingstone, S Shafi, H Zarif, G Ferns (2010)Insulin sensitivity (Si) assessment in lean and overweight subjects using two different protocols and updated software, In: SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION70(2)pp. 98-103 TAYLOR & FRANCIS AS
C Livingstone (2016)Selenium and Parenteral Nutrition, In: Complete Nutrition16(2)pp. 12-14 Complete Media & Marketing Limited (CM2)
Selenium (Se) is an essential micronutrient with antioxidant, anti-inflammatory and immunological properties. It is an important component of parenteral nutrition (PN). In 2012, ASPEN increased its standard recommendation on Se provision in PN for adults and recommended that commercially available multi-trace element (MTE) products should be modified accordingly. Some patients' Se requirements are higher than the standard recommendation. Nutrition support teams (NSTs) should be able to identify these patients and provide additional Se. Recently, there has been interest in supplemention of Se at high doses for critically ill patients to improve clinical outcomes. This is called pharmaconutrition. This article provides guidance on providing Se in PN and on its use as a pharmaconutrient.
S Redding, G Wark, C Livingstone (2012)Clinical validation of ELISA assays for insulin-like growth factor-II (IGF-II), In: Journal of Endocrinology and Metabolism2(2)pp. 72-81 Elmer Press
DOI: 10.4021/jem82w
AA Borai, A Farzal, C Livingstone, D Balgoon, A Al Sufyani, S Bahijri, I Kadam, K Hafiz, M Abdelaal, G Ferns (2015)Blood donation temporarily improves glycated haemoglobin (HbA1c) status in healthy men
JSN Dutt, C Livingstone, MF Cardosi, SJ Wilkins, J Davis (2006)A clinical assessment of direct electrochemical urate measurements, In: TALANTA68(5)pp. 1463-1468 ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2005.08.020
V Marvin, C May, C Livingstone, J Davis (2007)Incidence of hypophosphataemia in patients on parenteral nutrition, In: Hospital Pharmacist14(5)pp. 166-169
OBJECTIVE - To determine the effect of parenteral nutrition on plasma phosphate levels and to evaluate the incidence of refeeding hypophosphataemia. SUBJECTS AND SETTING - 250 adult patients started consecutively on parenteral nutrition (PN) were monitored at The Royal Surrey County Hospital, a 530-bed, non-teaching, secondary care trust incorporating medical and surgical care, paediatrics, intensive care, maternity services and a regional cancer centre. DESIGN - Data on plasma levels of magnesium and phosphate, relevant interventions performed and nutrition outcomes was collated by the Trust Nutrition Support Team. RESULTS - 36 patients (15 per cent) were found to be hypophosphataemic before commencing PN. 86 patients (34.4 per cent) developed refeeding hypophosphataemia within seven days after commencing PN. It was considered severe (less than 0.5mmol/L phosphate) in 10.8 per cent. Refeeding hypophosphataemia reached a nadir at three days and recovered in over 75 per cent of patients within 10 days without intervention. Cancer patients appear to be at greater risk than non-cancer patients for developing refeeding hypophosphataemia. Plasma magnesium levels did not mimic phosphate levels. CONCLUSION - Recognition of hypophosphataemia and the development of guidelines for its management in the care of PN patients are important.
F Faisal, K Whiting, C Livingstone (2013)An audit of body fluid requests in a district general hospital
C Livingstone (2013)IGF2 and cancer., In: Endocrine-Related Cancer20(6)pp. R321-R339
DOI: 10.1530/ERC-13-0231
Insulin-like growth factor 2 (IGF2) is a 7.5 kDa mitogenic peptide hormone expressed by liver and many other tissues. It is three times more abundant in serum than IGF1, but our understanding of its physiological and pathological roles has lagged behind that of IGF1. Expression of the IGF2 gene is strictly regulated. Over-expression occurs in many cancers and is associated with a poor prognosis. Elevated serum IGF2 is also associated with increased risk of developing various cancers including colorectal, breast, prostate and lung. There is established clinical utility for IGF2 measurement in the diagnosis of non-islet cell tumour hypoglycaemia, a condition characterised by a molar IGF2:IGF1 ratio >10. Recent advances in understanding of the pathophysiology of IGF2 in cancer have suggested much novel clinical utility for its measurement. Measurement of IGF2 in blood and genetic and epigenetic tests of the IGF2 gene may help assess cancer risk and prognosis. Further studies will determine whether these tests enter clinical practice. New therapeutic approaches are being developed to target IGF2 action. This review provides a clinical perspective on IGF2 and an update on recent research findings.
T Salter, J Marsh, B Sood, C Livingstone, H Gallagher (2015)Pseudohypercreatininaemia in two patients caused by monoclonal IgM interference with enzymatic assay of creatinine, In: JOURNAL OF CLINICAL PATHOLOGY68(10)pp. 854-U105 BMJ PUBLISHING GROUP
DOI: 10.1136/jclinpath-2015-203064
C Livingstone (2011)A case of postnatal hyponatraemia, In: CPD Bulletin Clinical Biochemistry10(2)pp. 67-68
A Borai, S Bahijri, C Livingstone, M Nawajha, A Bawazeer, Z Baarmah, A Shanaa, I Kadam, M Abdelaal (2014)Assessment of the use of serum separator tubes in measurement of 25-hydroxyvitamin D3 (25OHD3) by HPLC and immunoassay methods
C Livingstone, A Borai (2014)Insulin-like growth factor-II: its role in metabolic and endocrine disease., In: Clinical Endocrinology80(6)pp. 773-781
DOI: 10.1111/cen.12446
Insulin-like growth factor-II (IGF-II) is a widely expressed 7·5 kDa mitogenic peptide hormone. Although it is abundant in serum, understanding of its physiological role is limited compared with that of IGF-I. IGF-II regulates foetal development and differentiation, but its role in adults is less well understood. Evidence suggests roles in a number of tissues including skeletal muscle, adipose tissue, bone and ovary. Altered IGF-II expression has been observed in metabolic conditions, notably obesity, diabetes and the polycystic ovary syndrome. This article summarizes what is known about the actions of IGF-II and its dysregulation in metabolic and endocrine diseases. The possible causes and consequences of dysregulation are discussed along with the implications for diagnostic tests and future research.
A Borai, C Livingstone, G Ferns (2013)Reference change values for insulin and insulin-like growth factor binding protein-1 (IGFBP-1) in individuals with varying degrees of glucose tolerance, In: SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION73(4)pp. 274-278 INFORMA HEALTHCARE
C Livingstone, H Rampes (2006)Lithium: a review of its metabolic adverse effects, In: JOURNAL OF PSYCHOPHARMACOLOGY20(3)pp. 347-355 SAGE PUBLICATIONS LTD
LA Newton, K Sandhu, C Livingstone, R Leslie, J Davis (2010)Clinical diagnostics for homocysteine: a rogue amino acid?, In: Expert Review of Molecular Diagnostics: new diagnostic technologies are set to revolutionise healthcare10(4)pp. 489-500
DOI: 10.1586/erm.10.19
Homocysteine has gathered considerable interest in recent years after being implicated in the pathogenesis of various clinical conditions. It has been an elusive target with many conflicting studies casting some confusion over its significance, and much more needs to be done to ascertain its pathophysiological role--especially with respect to regimes aimed at lowering its plasma concentration. Central to this is the development of robust analytical strategies for its determination. This review summarizes the clinical relevance of homocysteine as a diagnostic marker of disease and explores and critically assesses the detection methods that have been developed.
SA Chitre, G-AM Lobo, SM Rathod, RB Smith, R Leslie, C Livingstone, J Davis (2008)Bromide-sulfur interchange: Ion chromatographic determination of total reduced thiol levels in plasma, In: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES864(1-2)pp. 173-177 ELSEVIER SCIENCE BV
DOI: 10.1016/j.jchromb.2008.01.040
Callum Livingstone (2019)Interpreting Biochemical Results - Part 3: Lipids Complete Media & Marketing Limited (CM2)
It is important for the dietitian to be able to interpret lipid profiles because the results usually have implications for the nutritional management of patients. The situations in which lipid measurements are requested can be divided into those occurring in non-acute settings − such as primary care and lipid out-patient clinics − and those occurring in acute settings. In non-acute settings, a lipid profile is usually requested when assessing cardiovascular (CV) risk, whereas in acute settings triglyceride alone is often measured for monitoring patients treated with nutrition support. This article discusses the interpretation of lipid results in these two settings.
Callum Livingstone (2019)Interpreting Biochemical Results - Part 1: Introduction Complete Media & Marketing Limited (CM2)
The ability to interpret biochemical results is an important skill for the dietitian, one which will become increasingly important as new tests relevant to nutrition are developed. Also, it is often the dietitian who has to act on results as well, either by adjusting nutrient provision or by advising medical colleagues to do so. Although plenty of information has been published on how to interpret biochemical results, the subject is not covered comprehensively in any one publication intended for dietitians. By consolidating some of the available information, this series aims to provide readers with practical guidance which they can apply in the workplace. In the space available, it will focus on the tests most relevant to dietetic practice, including those which can be difficult to interpret and on which dietitians often seek advice from laboratory staff. This first article provides general guidance both on requesting of tests and on interpreting the results.
Callum Livingstone (2017)Manganese Provision in Parenteral Nutrition: An Update, In: Nutrition in Clinical Practice33(3)pp. 404-418 SAGE Publications
Manganese (Mn) is an essential micronutrient required for the activity of metalloenzymes. It is an essential component of parenteral nutrition (PN), but requirements are low. Mn status is difficult to assess, with the commonest method being measurement of its concentration in whole blood. This method has limitations, including artifactually high concentrations resulting from contamination of specimen tubes. Mn toxicity is a well-recognized complication of PN, the risk of which increases if there is cholestasis or if the patient has received high doses. It usually presents with parkinsonian-like symptoms but may be detected presymptomatically as hypermanganesemia or as increased signal intensity of the basal ganglia upon T1-weighted magnetic resonance imaging. Caution is necessary when providing Mn for patients on long-term PN (>1 month). It is advisable to withhold supplementation if hypermanganesemia or cholestasis develops. Deficiency of Mn is rare in patients treated with PN. PN regimens are contaminated with Mn in amounts likely to meet requirements. Consequently, it is debated whether PN should be routinely supplemented with Mn. The currently recommended dose of Mn in adults treated with PN is 55 μg/d, but the doses provided by most currently available multi–trace element products exceed this. In response to calls for new products to be developed, 2 new multi–trace element products are currently available in Europe that provide Mn doses of 55 μg/d. Once these products are in general use, it is likely that the incidence of Mn toxicity will decrease.
J Hamilton, G Wark, C Livingstone (2014)An investigation into the clinical utility of serum IGF-I and IGFBP-3 measurement in adult patients receiving parenteral nutrition
A Borai, S Bahijri, C Livingstone, M Nawajha, A Bawazeer, Z Baarmah, A Shanaa, I Kadam, M Abdelaal (2016)Assessment of Becton Dickinson Plain and Serum Separator Tubes in Measurement of 25-Hydroxyvitamin D3 (25OHD3) by HPLC and Immunoassay Methods, In: JOURNAL OF CLINICAL LABORATORY ANALYSIS30(1)pp. 32-35 JOHN WILEY & SONS INC
DOI: 10.1002/jcla.21805
DFP Burut, A Borai, C Livingstone, G Ferns (2010)Serum heat shock protein 27 antigen and antibody levels appear to be related to the macrovascular complications associated with insulin resistance: a pilot study, In: CELL STRESS & CHAPERONES15(4)pp. 379-386 SPRINGER
Callum Livingstone (2017)Iron provision in parenteral nutrition, In: Complete Nutrition(17)pp. 10-13 Nutrition2me
Iron (Fe) is the most abundant trace element (TE) in the body. Although it is an essential nutrient there is no worldwide consensus on whether it should be routinely provided in parenteral nutrition (PN). Indeed, there is a transatlantic difference in practice, Fe being routinely provided in PN in Europe but not in the United States (US). This is reflected in the formulation of the multi-TE (MTE) products used in the two continents. This article discusses the provision of Fe for patients treated with PN, including the arguments for and against providing it in PN itself. It also discusses the assessment of Fe status in patients treated with PN.
E Walter, S Alsaffar, C Livingstone, SL Ashley (2015)Manganese toxicity in critical care: Case report, literature review and recommendations for practice, In: Journal of the Intensive Care Society Sage Publications
We present the case of a 62-year-old man on the intensive care unit with pancreatitis. Since early in his admission, and for the remainder of his prolonged stay in intensive care, he has received parenteral nutrition for intestinal failure. The whole blood manganese concentration was significantly increased after 2½ months of parenteral nutrition (PN). Three months into his stay, he developed a resting tremor and extra-pyramidal dyskinesia. In the absence of other neurological symptoms, and with no history of essential tremor, Parkinsonism or cerebral signs, hypermanganesaemia was presumed to be the cause. We review manganese metabolism and toxicity in patients who are fed with parenteral nutrition and review the current recommendations and guidelines.
P Bahado-Singh, G Wark, C Livingstone (2015)An audit of insulin and C-peptide requests received by the Peptide Hormones Supraregional Assay Service (SAS)
Callum Livingstone (2019)Interpreting Biochemical Results - Part 2: Trace elements Complete Media & Marketing Limited (CM2)
Serum TE levels have limitations which make the results difficult to interpret, especially in the acute setting. Because of these limitations, practitioners need to consider factors other than TE levels when assessing TE status. This article discusses five TEs encountered in dietetic practice namely zinc (Zn), copper (Cu), selenium (Se), manganese (Mn) and iron (Fe) suggesting a practical approach to assessing the status of each. For the purposes of description they are considered individually, but in practice they should be considered together. There is a need for new tests of TE status to be developed which are reliable in the acute setting. Until such tests are available, the assessment of TE status will entail some uncertainty and practitioners should be mindful of this when deciding on TE provision.
A Borai, A Farzal, C Livingstone, D Balgoon, A Al Sufyani, S Bahijri, I Kadam, K Hafiz, M Abdelaal, G Ferns (2015)The effect of whole blood donation on metabolic indices and iron stores. Blood donation temporarily improves glycated haemoglobin (HbA1c) status in healthy men
C Livingstone (2012)The insulin-like growth factor system and nutritional assessment., In: Scientifica2012pp. 768731-768731 Hindawi Publishing Corporation
Over recent years there has been considerable interest in the role of the insulin-like growth factor (IGF) system in health and disease. It has long been known to be dysregulated in states of under- and overnutrition, serum IGF-I levels falling in malnourished patients and responding promptly to nutritional support. More recently, other proteins in this system have been observed to be dysregulated in both malnutrition and obesity. Currently no biochemical marker is sufficiently specific for use in screening for malnutrition, but levels may be valuable in providing information on nutritional status and in monitoring of nutritional support. All have limitations as nutritional markers in that their serum levels are influenced by factors other than nutritional status, most importantly the acute phase response (APR). Levels should be interpreted along with clinical findings and the results of other investigations such as C-reactive protein (CRP). This paper reviews data supporting the use of proteins of the IGF system as nutritional markers.
C Livingstone (2016)Copper and Parenteral Nutrition, In: Complete Nutrition16(1)pp. 30-32 http://www.nutrition2me.com/publications
Copper (Cu) is an essential trace element which is an important component of parenteral nutrition (PN). The Cu status of patients is difficult to assess, mainly because of the limitations of currently available laboratory tests. This can make it difficult to decide on the amount of Cu to provide in PN for individual patients. However, it is important to provide the correct amount if Cu deficiency and toxicity are to be avoided. This article provides guidance for nutrition support teams (NSTs) on assessing Cu status and estimating individual requirements in patients treated with PN.
H Tayler, C Livingstone (2006)An unusual case of polyuria, In: CPD Bulletin Clinical Biochemistry7(3)pp. 122-123
L El-Alem, CJ May, C Ali, C Livingstone, GJ Sadler (2012)An evaluation of the impact of a multidisciplinary nutrition support team on the provision of parenteral nutrition in an NHS foundation trust hospital, In: Digestive Disorders Federation Meeting
A Borai, C Livingstone, A Farzal, M Kholeif, T Wang, G Ferns (2010)Reproducibility of HOMA and QUICKI among individuals with variable glucose tolerance, In: DIABETES & METABOLISM36(3)pp. 247-249 MASSON EDITEUR
DOI: 10.1016/j.diabet.2010.01.006
A Borai, C Livingstone, A Algithami, A Bazuhair, A Al-Ansari, S Baatta, D Alrowaili, N Mohammed (2015)Preanalytical stability of 25(OH)-vitamin D using immunoassay testing, In: Proceedings of the 1st Annual Conference of the Saudi Society for Clinical Chemistry
IA Solsona, RB Smith, C Livingstone, J Davis (2006)Metabolic mimics: Thiol responsive drug release, In: JOURNAL OF COLLOID AND INTERFACE SCIENCE302(2)pp. 698-701 ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2006.06.042
A Borai, C Livingstone, G Ferns (2012)Insulin and IGFBP-1: Reference change values and intra-individual variation in individuals with a varying glucose tolerance
C Livingstone (2008)Hypoglycaemia: a nutritional perspective, In: Comp Nutr(8)pp. 14-16
MM Villalba, VJ Litchfield, RB Smith, AM Franklin, C Livingstone, J Davis (2007)A chromatographic tool for preparing combinatorial quinone-thiol conjugate libraries, In: JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS70(5)pp. 797-802 ELSEVIER SCIENCE BV
DOI: 10.1016/j.jbbm.2007.04.008


Update: We came up with one more idea! Keep reading for 11 great ideas for basil. Let us know if we missed any in the comments. Nothing says summer (to me) like fresh basil. Mostly because after fresh basil comes from fresh tomatoes! (I'm looking out the window at our high tunnel tomatoes as I type this, counting the days until they ripen) Every week when the crew brings in the huge bunches of genovese and now Thai basil I can't wait to open my csa share box. Personally, I enjoy making lots of pesto in the summer, and then freeze it to use later, but I know that huge batches of pesto aren't everyone's thing and honestly basil is so much more versatile then just pesto. Read on for more ideas to get the most out of our plentiful bunches of basil.
Pesto. Pesto is the condiment of summer, and if you make larger batches it freezes beautifully. I currently have various containers filled with three types of pesto in my freezer. Fresh pesto is perfect tossed with pasta for an easy meal – add grilled chicken or shrimp, beans like chickpeas or cannelini, and when those tomatoes ripen big chunks of heirloom tomatoes. Spread over wild Alaskan salmon and grill, mix equal parts with mayo for an awesome sandwich spread or just spread pesto onto any and all sandwiches. (Try pesto mayo on a blt, one of my favorites) Check out our pesto tab – we have traditional and dairy-free options.
Basil Oil. Here's any easy and great way to preserve basil. Blend and gently simmer it into a basil infused oil. The oil keeps for about a week in the refrigerator, and can be frozen in smaller portions to toss with pasta or add to dressings. This is a great way to add mild basil flavor to dishes.
Salads. I love adding whole leaves of basil to salads. One of the things about basil is once washed and chopped it can start to turn dark and blacken around the edges. Most of the time it still tastes fine, but adding the leaves whole to salads is a nice solution. Try Summer Squash Ribbons with Basil & Pine Nuts or Grilled Radicchio Panzanella.
Salad Dressing. Add a tablespoon or two of basil chiffonade to homemade dressings and marinades. What's basil chiffonade? Wash and dry your basil. Stack the leaves on top of each other and thinly slice. This is the easiest way to slice basil. Check out our tutorial on salad dressing, and this Grilled Pepper Salad.
Eggs. Fold pesto into omelets and swirl into frittata. Top scrambled eggs with fresh basil or sprinkle over quiche.
Drinks. Try infusing your favorite summer beverages or cocktails with fresh basil. Simmer into simple syrup or blend into juice and strain. Basil pairs really well with citrus based drinks like lemonade, limeade, and grapefruit juice. Garnish each glass with a sprig of fresh basil!
Caprese Salad. A classic Italian dish that requires no recipe, but here's our family favorite. Slice heirloom tomatoes thick, drizzle each slice with 2-3 drops olive oil, and one drop balsamic vinegar. Sprinkle with salt and pepper. Top each slice with a basil leaf and a thick slab of fresh mozzarella. Top the mozzarella with a few slices of kalamata olive (optional).
Freeze. There's really nothing better than saving some fresh summer produce in the back of the freezer, it can really lift your spirits on a dreary winter day! Don't freeze whole basil leaves, they'll just turn black. Instead, wash and dry the basil. Pulse in a food processor with enough olive oil to coat each leaf. Freeze in small containers or ice cube trays. Thaw and add to pastas, vinaigrettes, and salads. Here's more on freezing herbs.
Stir Fries. Typically thai basil is used in stir-fries, it is a little hardier and stands up well to coking. You can also remove the stir-fry from heat and add genovese basil before serving. Pairs great with noodle dishes.
Desserts. Sounds wild, but basil is also an excellent pairing to stone fruits like cherries, plums, peaches and also berries. Try poaching summer fruit with basil and water, adding it to homemade ice cream, and pairing with watermelon. Try our Basil Cherry Cobbler.
Marinara. Try our Simple Marinara Sauce recipe, basil is added to the onions while they are sautéing and also at the end.


This article was written by Coco Quillen, VP of Operations at Davinci Virtual Office Solutions. She manages the strategic development and operational implementation of services for Davinci and works closely with all teams to ensure customers are well taken care of.
We are talking, of course, about women in leadership. Even with all the progress we've made for equality in so many important ways, women are still severely underrepresented in business leadership positions. Women-led companies make up only 4% of Fortune 500 companies, a trend that holds steady throughout most business sectors.
This inequality could be, in part, because not everyone is on the same page when it comes to understanding the importance of women in business. Some believe women should be capable of reaching leadership on their own, while others don't understand what makes women suited to the job.
Thankfully, not everybody is buying this. Many businesses and industries are waking up to the reality that women in leadership not only bring important benefits, but that they are an absolutely invaluable and irreplaceable resource in the office, in the boardroom, on the Senate floor, at the podium, and at the head of the table.
Here are just three reasons why promoting and supporting female leaders should be a top priority for all businesses.
Don't think women have what it takes to negotiate in high-stakes situations? It has been well documented that women are often more effective at making deals than men, even when the stakes are as high as the highest governing body in the land. In fact, women in the Senate are better at working with people of different viewpoints and opinions to get things done than their male counterparts. These women leaders drive bipartisan collaboration and cooperation and help move things along in a governing body that is notorious for deadlock and infighting. In short, if you want a bill to get through Capitol Hill, you will have a better chance if you get female senators to sponsor, support, and champion the bill.
In business, female leaders can achieve agreements and make deals where men might fall short. But they have to be at the table, and they have to be given positions of leadership and authority.
The gender pay gap is a maddening phenomenon that has persisted despite decades of progress in the workplace. For too long, experts have been looking for a way to close the gender pay gap (women make 77.9 cents per every dollar that men earn) without much meaningful progress. But one of the most promising solutions is the initiative to empower women to gain leadership positions.
In reality, there isn't just a gender pay gap—there's a gender opportunity gap. According to the PayScale article referenced above, women and men start their careers making roughly the same amount of money for the same work, but men are offered more opportunities to advance into higher-paying leadership positions. Halfway through their careers, men are 70% more likely to be in executive positions than women, and towards the end of their careers, men are 142% more likely to fill the offices of the C-suite than women.
Since leaders in an organization are, as a rule, paid more, it makes sense that elevating more women in business and leadership can help close the pay gap. However, that's only part of the story. Women in leadership position are better at providing others with fair pay and good benefits, according to a Pew Research survey from 2014. It's not enough for a few women to make it to the top at the expense of their peers—we need all women to succeed and we want business to thrive at the same time. After all, a rising tide lifts all boats, and having women in leadership will help spur industry on a large scale, which brings us to our third point.
In the same Pew Research survey referenced above, respondents identified women leaders as being better than men in the areas mentoring and guiding young employees. But this is almost beside the point because, in reality, all people need good mentors to help them progress in their careers and aspirations, regardless of the mentor's gender. It's unproductive to argue that women are better mentors—the truth is that we need more mentors overall in order for women to succeed.
Currently, one of the obstacles women face is that men are less likely to mentor women than they are to mentor other men. On the other hand, women are much more likely to mentor other women than they are men. The solution isn't to have men only mentor men and women only mentor women. That would be insanity. But by having more women in leadership positions, you're setting them up to be brilliant mentors of the next generation of women leaders. And by encouraging successful men to fill the role of mentor for aspiring women leaders, we get even closer to equality in the workplace. It has to be a team effort, or gender disparities will continue to persist.
Our company, Davinci Virtual Office Solutions, is working hard to close the gender-leadership gap. In addition to employing a workforce that's 90% female professionals, Davinci has pledged its participation in the ElevateHER Challenge, an initiative that seeks to promote women in business, particularly in leadership. Beginning in the Spring of 2018, Davinci joined over 40 Utah-based companies as part of this global movement, which involves taking 7 distinct steps each aimed at elevating women to leadership roles within the company.
Davinci believes in the value of female leadership—in having a diversity of voices in the business discussion—and is proud to be part of a movement to give women the opportunities they deserve.


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Tibetan Political Review
TPR in Tibetan
Recipient of the 2014 Lhakar Award for Journalism,
cited by the U.S. Congressional Research Service,
and published in Cultural Anthropology.
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There is no middle without the ends
posted Mar 15, 2015, 5:48 PM by The Tibetan Political Review
By Tenzin Gelek
There is little doubt that what happened in NY on March 10 2015 was unpleasant to witness and certainly condemnable. But whatever be the immediate cause of that incident and however we try to justify it, I take consolation in the fact that it brought some deeply dissenting issues to the surface. This is the beauty of democracy and the function of free society; that there is a perpetual friction caused by differing views, which then lends space for dialogue and discussion. Although, like many others, I would have preferred that this heated debate took place in the halls of the Tibetan Parliament in Exile rather than the streets of New York. But it happened and we need to deal with it instead of sweeping it under the rug.
Without going into the details of what happened or who caused it, when I analyze this incident, I see two underlying issues – the divide between the advocates of Middle-way and Rangzen leading to the somewhat ostracization of the latter and the definition of March 10 in the light of this divide going forward. Before I elaborate my views on these, let me unequivocally state, so as to remove any indication of bias, that I support the Middle-way and have done so since its inception. In my recent past, I have involved myself in some activities that aim to advance the cause of Middle Way.
One such event was a discussion with Chinese students and one of the key speakers was Sikyong Lobsang Sangay la. At the time, he was speaking in his capacity as a Harvard legal scholar and therefore, I will refer to him as Dr. Lobsang Sangay la in this account. He was presenting the legal view on the case for Tibetan Independence. At the end of the talk, I recollect a Chinese student walking up to him and asking him and I am paraphrasing, "This conference is about dialogue and understanding and yet in your presentation, you talk about Tibetan Independence?". To which, Dr. Lobsang Sangay la responded, "It is important to remember what the Tibetan people have the right to and only then will there be substantial dialogue." Of course, I am recollecting this from a distant memory and I may have taken some literary liberties with it. However, the content is relevant to the discussion of the aforementioned issues.
The next generation of Tibetan and Chinese population needs to be reminded. And most of all, the Chinese government needs to be reminded. No other day is as symbolic as March 10 to serve as that reminder. It is an important landmark in the history of Tibetan people's struggle. If we look at the events leading to M10, there is no doubt that there was a deep resentment against the Chinese policies in Tibet and a fierce longing for freedom from the oppressive rule. As far as I can see, both the conditions still exist today.
The watershed moment on March 10, 1959 when thousands of Tibetans surrounded the Norbulingka Palace to protect His Holiness the Dalai Lama is also important to remember. For the Tibetan people, His Holiness is not just a religious leader but our idea of Freedom, Nation and Identity is intertwined with him. This also remains true even today. Since the conditions that led to M10 still exists, our collective voice should also resonate with the deafening cries heard on the streets of Lhasa. And I believe that M10 should be commemorated with same fervor as that fateful day in Lhasa.
With regards to the issue of MW v/s Rangzen, I think that this is an unnecessary divide created only due to our limited perception and the lack of political imagination. Let me try to articulate the reasoning for both the voices to co-exist in our community. The Middle-way is a practical solution proposed to the ongoing conflict between the Tibetan administration representing the Tibetan people and the Chinese government. In the most simplistic form, it is aimed at striking a balance between the Chinese government's current policies of reckless assimilation of Tibetans and the state-sponsored sinicization of Tibet and the Tibetan people's claim for an Independent Tibet. I am of the opinion that until both the parties meet in the middle and that agreement is ratified, we should not give up our hand just yet. For the Middle-way to make sense and for it have any weight at the negotiation table, the Rangzen faction has to exist. The Chinese government has to be reminded of the stake they have in the Middle-way being successful. As such, it behooves us not shut out the Rangzen supporters for that reason and many others – namely – Freedom of speech, choice etc guaranteed under a democratic establishment.
Having said that, I do want to speak to my own rationale to support the Middle-way policy and it has nothing to do with my devotion to His Holiness. Well, that is partly untrue because my undying devotion and faith stems from witnessing in person the relentless hard work of the Great 14th Dalai Lama. And that being in the center of everything related to Tibet for over 60 years and having dealt with all the Chinese leaders from Mao to Xi, and countless heads of states have accorded His Holiness with the breadth of political and diplomatic experience that should be respected. But for this discussion, I do want to separate the Middle-way policy from His Holiness and examine it purely on its own merits.
I am a pragmatist and the current situation inside Tibet, the geopolitical and the economic reality of the world compel me to compromise and prioritize. If the circumstances were different, we can of course revisit this discussion, but based on the current realities, it is hard to entertain this romanticized notion of Independence. In my mind, there are two Tibets that need to be freed– a Tibet of the hearts and minds consisting of the Tibetan language, religion, culture and customs. And another, a landlocked geographical region that is nestled between China and India. The former is able to survive without the latter, as is evident from the Tibetan diaspora but the latter is irrelevant without the former.
In a perfect world, both the Tibets converge into an Independent Tibet. However, in the real world, we all know that the first Tibet is under persistent threat and it is this Tibet that the Middle-way strives to protect and preserve. It is this Tibet that is not only important to us Tibetans but crucial for millions of Chinese seeking spiritual solace and for the world in general. This is why I support the Middle-way, not because I want to sell-out Independence; not because I want to kowtow to the Chinese communist regime. But because I am a pragmatist who recognizes that we live in a globalized, interdependent world where peaceful co-existence is paramount.
In conclusion, I know that my fellow Tibetans who support Rangzen will not agree with some of what I have said but please know that these words come from the same place as yours – a deep love for Tibet and a categorical opposition to the present situation in Tibet. The Middle-way is a policy adopted by our democratic parliament to provide a diplomatic solution to what is a deadlock currently. Rangzen, at present, is an aspirational concept but if you could lay out in detail the vision, the strategy, the tactical approach and what the future of an Independent Tibet would look like in the face of a Nuclear China, please publish those. I cannot guarantee that I will change my mind but I will absolutely read it and debate its merits with you. For I am willing to risk offending the empty chairs across the negotiation table than to face the dangers of a divided movement.
The author is a concerned Tibetan professional living in the San Francisco Bay Area.
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Mons. Karlic, former president of the Episcopal Conference of Argentina, visited Medjugorje
Archbishop Estanislao Esteban Karlic, Archbishop Emeritus of Paraná, Argentina, and former president of the Episcopal Conference of Argentina, visited Medjugorje on February 13 and 14, 2007. Mons. Karlic, who received his Episcopal consecration 30 years ago, is now member of the Commission of Faith and Culture in the EC of Argentina. He stayed in the parish house, where the parish priest Dr. Fr. Ivan Sesar informed him about the pastoral work with the pilgrims and the life of the parish. Mons. Karlic expressed his admiration about the intensity of the sacramental life here.


My story this summer has been crazy, hectic, and a bit off kilter. While I love having both my kids at home during summer break, it has been really hard to keep myself sane and on-track.
As most parents can relate, my food intake has been more centered around the kids than keeping my body properly fueled and burning strong. While I work with many lovely women each week, my personal workouts have suffered as a result of mommyhood.
Don't get me wrong, this summer has also been productive as I was able to put together upcoming Core Boot Camp classes in my community and website www.fitgirltraining.com. These are HUGE accomplishments!! While I'm super excited about all that is in store, I'm comforted by getting back into my own routine of eating healthfully, heavy lifting, and having a little sanity during the day.
Women Rock Minnesota is coming up August 31 sponsored by the Team Ortho Foundation.
Participants can run a 5K, 10K, or half marathon. Men of Rock Minnesota will be handing out sterling silver, ruby and diamond finisher's pendants at the end of the race (even champagne).
Participated in this race? I'd love to hear about your experience. Have a great day!
Get out. Whether it's 20 minutes or 2 hours. It Matters!
Give yourself 10 minutes everyday to . . . stretch, run, walk, dance, bike, blade, swim, volley, drive balls, do push ups, jog, kick, jump, squat, dribble, pass, lift, tuck, swing, pass, play, hike, climb, ski, punch, kick, block, row, garden, skate, chop, paddle . . .
JUST 10 minutes of exercise EVERYDAY!
When I was little, I believed that I was not smart enough to go to college. As a parent, I sometimes believe "I'm not good enough" at getting my point across or teaching my children life lessons.
The words "I'm not good enough" should be BANNED because the reality is that we can be good at anything we choose.
YOU can do anything YOU choose!!
Women often fail to ask for what they want and automatically tell themselves "no" it isn't possible, it's not an option, it'll never happen . . .
Dare to ask for what you want and take that step forward - anything is possible, life is full of options, and it could happen for YOU!


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Cerkiew Świętych Cyryla i Metodego – prawosławna cerkiew-pomnik wzniesiona z polecenia carskich władz Chełma w 1884.

Świątynia powstała w celu upamiętnienia dziesiątej rocznicy likwidacji unickiej diecezji chełmskiej w 1884. Autorem jej projektu był rosyjski architekt Wiktor Syczugow. Była usytuowana w najwyższym punkcie Wysokiej Górki w Chełmie.

W 1921 została rozebrana. Jej zniszczenie wpisywało się w kampanię usuwania z polskich miast budynków sakralnych zbudowanych przez władze carskie w celach rusyfikacji i propagowania prawosławia.

Przypisy

Cyryla
Rosyjski Kościół Prawosławny w Królestwie Kongresowym
Chełm
Chełm
Chełm

redpajama_set_name: RedPajamaWikipedia


The Governor's release came just a day after Senate leader Phil Berger issued a similar list of "accomplishments" under a Lincolnesque photo of himself gazing into space and the headline "Reflecting on a Productive Year." House Speaker Tim Moore, who's been a trifle busy of late waging a nasty fight with fellow House Republicans and dealing with an FBI investigation into his campaign finance practices, has yet to issue such a formal statement.
And while placing some kind of a bond package to fund state infrastructure before voters this year is probably a good idea, McCrory's claims about paying off "$2.8 billion in federal debt" and putting more money in the paychecks of average people by cutting taxes are both wildly off-base.
The debt payoff was, of course, accomplished by imposing what were likely the largest and most devastating cuts to unemployment insurance benefits and eligibility in modern American history. In other words, McCrory is claiming credit for inflicting unprecedented pain on the incomes of hundreds of thousands of struggling North Carolinians and the businesses (grocery stores, gas stations etc.…) that they would have patronized with more cash in their pockets.
Such changes have no more to do with "modernization" than do rolling back hard won voting rights, environmental protection laws or women's reproductive freedoms.
Despite the Governor's cheery attempts at spin, the plain and unavoidable truth is that state leaders did precious little in 2015 (or 2011, '12, '13 or '14, for that matter) to improve the lives of average North Carolinians. For a classic example of how the Governor's claims fail to mesh with reality, compare his assertions about supposedly boosting education spending with this recent WUNC radio story in which reporter Reema Khrais highlighted the numerous North Carolina public school teachers who are working multiple jobs in an effort to make ends meet in light of their abysmal salaries.
In a similar vein, compare McCrory's claims of pride in the state's environmental protection work (a statement back-dropped in the video by images of beautiful natural scenes) with the amazing list of destructive acts that the state has actually taken in recent years to dismantle environmental protection efforts.
Actual state unemployment is nearly double the official measure.
Employment levels in the state are still well below what they were at the start of the Great Recession.
"High tech" states are outperforming "low tax" states.
North Carolina workers are receiving less and less of the value they create.
State average hourly wages are not keeping up with national wages.
Wages for African Americans and Hispanic Americans are falling even further behind.
The state minimum wage doesn't come close to providing a living income.
The percentage of people living in poverty remains well above pre-Great Recession levels.
Many hard hit areas of the state continue to see poverty rates in excess of 25%.
State appropriations remain at historically low levels.
In other words, try as he will to make lemonade out of the lemons his administration and the General Assembly have churned out, there's simply no getting past the fact that North Carolina's overall health and wellbeing have been on a downward trend for several years – a drift greatly exacerbated in 2015. At a point in our history during which we could well be leading the rest of the southeast, and indeed the nation, on a path toward sustainable prosperity, North Carolina is, as we reported last October, a drabber, shabbier and more divided state that is racing to repeal much of the progress of the 20th Century.
In his recent and comprehensive review of the year in state policy, North Carolina Council of Churches commentator Steve Ford explained in detail what really happened last year and how little impact Governor McCrory really had on most issues. Seen through this lens, it is perhaps understandable that the Governor felt compelled to spin the narrative as aggressively as he did in the New Year's Eve video. Better to claim credit for controversial and destructive acts that weren't really even one's doing, goes the cold political calculus, than to be seen as completely irrelevant. Sadly, given the state of our big money-dominated and lightly reported politics in 2016, he may just be right.
Will McCrory veto legislative leaders' brazen power grab?
University leaders or superstar CEO's?


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Come visit Southern Chics for Your Christmas apparel and Christmas Shopping-the South's Favorite T-shirt Company.
Boutique Wrist Wear for the individual with discerning taste, unique style and a bit of flair… where exceptional quality is the standard.
Rooted in Custom Picture Framing, our assortment of everyday and seasonal home décor includes unique picture frames created in our framing workshop.
Amazing Handmade Single and Double Bows! For all of your holidays, school teams and many other occasions! Special orders and accepted as well as take home bows on site!
Simply Sawyer-Grace is a women's online clothing store, which offers the latest fashion in women's apparel. Visit www.shopsimplysawyergrace.com!
LMac Holiday Decor & Wreaths provides hassle-free Holiday decorating. Our services includes: fully decorated Christmas Trees, Wreaths, Garlands, and Swags.
Beautifully functional stoneware pottery made by local artist Susan Rodrigue is food safe as well as oven, microwave and dishwasher safe. Makes a great gift for that special person…including yourself!
We purchase fruits and vegetables from local farmers and makes delicious homemade pepper jellies, fruit jams and vegetable preserves.
Sweet Tabletops provides, Handcrafted Sweets and Sweets Table Styling . Handcrafted Sweets make great party favors and the perfect gift for any occasion.
Hand painted Platters and Home Décor , Cutting Boards, Towels and Pot Holders, and much more, all with a Louisiana Flair.
We are here to teach and educate you on Redox Signaling Molecule Health at a Cellular Level.
Metal Art and Copper Jewelry.
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