text:
Posted: Friday 12 July, 2019 at 7:39 AM
Allers on $100K bail for breaching Court Order
By: Stanford Conway, SKNVibes.com
BASSETERRE, St. Kitts – POPULAR businessman Ashley Allers of Jones Street, Fortlands was on Saturday (Jul. 6) granted bail in the sum of $100,000 with seven conditions, after he had breached his previous bail conditions in December 2018.
Allers, who is charged with two counts of Rape, allegedly committed on February 3, 2018 and March 31, 2018, was first granted bail on July 6, 2018 with conditions; one of which was that he was not to come within 100 meters of the virtual complainant (VC) or to have any contact or interfere with her.
The businessman however violated the court order, the bail was revoked and he was remanded to Her Majesty's Prison on January 21, 2019.
Allers has since been granted bail and, in addition to the $100,000, he has to report to the Basseterre Police Station twice weekly; observe a daily curfew; no contact should be made with the VC; not to come within 100 meters of the VC; surrender all travel documents; surrender any and all firearms in his possession; and to keep the peace and be of good behavior.
He is scheduled to appear at the Basseterre Magistrate's Court on August 23, 2019.
Circumstances pertaining to the judgment handed down by Resident Judge Trevor M. Ward, QC, at the Eastern Caribbean Supreme Court, St. Christopher Circuit that was brought against Allers for breaching his bail conditions, can be found online – "Director of Public Prosecutions V Ashley Allers".
The document states that the VC declared that while standing outside BCA on Central Street during J'ouvert morning on December 26, 2018, she had observed Allers was walking quickly towards her.
She claimed that he charged at her saying, "You see you, you see you", while at the same time raising both of his hands and pointing them aggressively at her face. He was about one foot away from her.
However, an off duty police officer, Leroy James, who was functioning as a Disc Jockey outside BCA, quickly intervened and restrained Allers.
The document also states that in his supporting affidavit, James "averred that he observed the respondent approaching the complainant. He appeared angry and was saying something to her. James immediately stopped what he was doing, approached the respondent and pushed him away, admonishing him to leave the complainant alone. The complainant then left the scene immediately and reported the confrontation to the Basseterre Police".
It further states that in his affidavit in response to the VC's claim, Allers contended that because of their long standing relationship, the VC was well aware that for years he attended BCA every J'ouvert morning as she would object to his presence there.
Allers and the VC were involved in an intimate relationship for about 17 years.
Allers had earlier that morning been confronted by a person whom he said was dating the VC and that he had reported both to the police. He also said while on his way back to BCA he was surprised to see the complainant standing at the entrance to BCA and deduced that she had deliberately positioned herself there to either provoke or place him in a position to breach his bail conditions.
He claimed that in a state of disbelief, he stopped walking and pointed at her saying, "You see you." He said he uttered those words out of shock and frustration but not in a threatening manner, and that it was at that point James intervened, pushing him inside of BCA and telling him to stay inside to avoid any confusion.
The background circumstances that led to the imposition of the bail conditions were the two counts of rape with which Allers was charged.
The court was told that on February 3, 2018, by mutual consent, Allers was at the VC's house to spend the night. "He demanded sex, she refused and so he raped her and forced her to perform fellatio."
The incident was not immediately reported to the police. However, in the ensuing days he continuously harassed the VC with text messages. And on March 15 he followed her vehicle to Frigate Bay and back to Basseterre, which led her to report the rape incident.
Inspector James Francis, head of the Criminal Investigations Department, had visited Allers at his business establishment that said day, informed him of the allegations and warned him to stay away from the VC.
The court was also told that on March 31, 2018 Allers had uninvitingly entered the VC's home, assaulted her and also threatened to kill her. He then placed his licensed firearm on the ground before ordering her to perform fellatio on him.
Following that act, he led her to the bedroom and raped her while positioning the firearm at the foot of the bed. Thereafter, he ordered her into his vehicle and drove to Ocean's Edge.
However, when the vehicle came to a halt at the guard booth to the property, the VC seized the opportunity to run to the guard and begged him to call the police. Allers then took hold of her and started to drag her towards his vehicle, but a police officer had intervened.
At that bail hearing, Allers was represented by Attorney-at-Law Jason Hamilton and the DPP was represented by State Counsel Teshaun Vasquez.
The court was satisfied that the situation between Allers and the VC was a volatile one, noting that he was "well aware of the conditions of his bail, and by his admission, even thought that he was being set up to breach them yet made a conscious decision to continue in the direction of the complainant and to engage her aggressively in clear breach of bail instead of turning off and putting distance between them. But for the quick intervention of Leroy James, the situation could have rapidly escalated with dire consequences".
At the end of the bail hearing, Ashley Allers was remanded to Her Majesty's Prison on January 21, 2019.


Happy 21st Birthday, Chrissie! (April 28, 2006) Lord, be with Chrissie as she embarks on her last year of Bible/Teacher's college, and guide her as she moves into the next phase of her life.
This essay really blew my mind. It just looks at attitudes towards courtship within Christian circles and deconstructs them.
"There is no safe investment. To love at all is to be vulnerable. Love anything and your heart will certainly be wrung and possibly be broken. ... The only place outside Heaven where you can be perfectly safe from all the dangers and perturbations of love is Hell."
I found it shocking. [Now] I feel feel empowered and new!
Click here for the full essay.
You probably don't know who this guy is, and you will probably never meet him. But he needs your prayers.
Please pray for Wayne and Veronica Guindon (in the prayer handbook) in El Salvador. They were assualted by a gang of guys in balaclavas and sawed-off shotguns. They only wanted "liquid cash", not being interested in anything other than $, jewelry and cell phones. Wayne suspects they are trying to spring their leader from prison. They came back a week later and did it again. They were quite traumatized as Vero and the kids were hiding in a closet as they had Wayne at gunpoint. They were forced to leave their home, fearing kidnapping, and are staying at a friend's. They had just returned from furlough in Canada. Now it looks like they are considering moving to Canada for now. The problem is that Vero, being Guatemalan, would have to apply for residency which is proving very complicated. They are making it very hard for her to emmigrate to Canada. ... Wayne is a dear brother and friend. He would be content to lay down his life on the field rather than return but is being a good father to his young family. He is burdened and in need of our prayers.
This picture (click for full size) of an Iraqi child giving a U.S. soldier 'five' reminds us that all of the people involved are just that -- people.
Lord, we pray for Iraq. Use the unrest to reach her people with the solution: Yourself. Out of the shambles of Iraq, build your Church.
Pray for Shawn C. With another shooting in their area, the sudden uncertainty surrounding their two 'kids' Cookie and Kellz, and a host of other challenges in their lives--read all about it at Shawn's blog--these guys need our prayers. My friends Brit, Chris and Will and I dropped by Shawn's youth group last night, and got slaughtered in basketball by his guys. As one of them put it, "Old skool vs. new skool, and new skool won."
God bless you as you pray and obey this week.


text:
Q: How can I fetch an unmerged pull request for a branch I don't own? I need to pull in a specific pull request (that hasn't been processed into the main stream yet) in the NServiceBus repo:
https://github.com/johnsimons/NServiceBus/commit/d8524d53094e8181716e771c1023e968132abc15
It's obviously not my repo, but I need the changes that exist in that pull request.
What is the best way to do this?

A: For difficult situations (especially if you have not a checked out git-repo), I think the simplest way is to apply a patch. For this just open the pull-request on github and add a ".patch" to the URL, download it and apply the patch.
Example:
cd cordova-plugin-media
wget https://github.com/apache/cordova-plugin-media/pull/120.patch
patch -p1 < 120.patch

A: git pull origin pull/28/head

Or
git fetch origin pull/28/head:28
git checkout 28

Can I pull a not-yet-merged pull request?

A: To fetch a pull into your repository:
git fetch git@github.com:jboss/jboss-common-beans.git refs/pull/4/head

Then do whatever you want with FETCH_HEAD:
git checkout -b new-branch FETCH_HEAD

A: See this help article from GitHub: https://help.github.com/articles/checking-out-pull-requests-locally

A: github/hub
https://github.com/github/hub is a GitHub CLI helper that deals with this and other use cases beautifully using extra information from the GitHub API. E.g.:
git clone https://github.com/github/hub
# Just copy paste the URL.
hub checkout https://github.com/github/hub/pull/970

Result:

*

*we are now on a branch called <USERID>-<BRANCH_NAME> that contains the PR.
Note the good branch name which was automatically set for us.

*that branch is set to track the original branch on the fork, i.e. .git/config contains:
[branch "<USERID>-<BRANCH_NAME>"]
    remote = retronym
    merge = refs/heads/ticket/969
    rebase = true

So if further commits get pushed, we can git fetch them directly.
Installing hub on Linux is currently a pain if you're not familiar with Go, but worth it. On Ubuntu 14.04, the Go on the repositories is too old, so GVM is the best option:
bash < <(curl -LSs 'https://raw.githubusercontent.com/moovweb/gvm/master/binscripts/gvm-installer')
. "$HOME/.gvm/scripts/gvm"
gvm install 'go1.4'
gvm use 'go1.4' --default
go get github.com/github/hub

I have also asked GitHub to give us a copy paste cheatsheet on the web UI at: https://github.com/isaacs/github/issues/449

A: Once you added the upstream repo as an upstream remote (as @elias pointed out):
$ git remote add upstream git@github.com:Particular/NServiceBus

You can configure git to fetch pull requests by default:
$ git config --local --add remote.upstream.fetch '+refs/pull/*/head:refs/remotes/upstream/pr/*'

So, let's fetch it:
$ git fetch upstream
Fetching upstream
remote: Counting objects: 4, done.
remote: Compressing objects: 100% (2/2), done.
remote: Total 4 (delta 2), reused 4 (delta 2), pack-reused 0
Unpacking objects: 100% (4/4), done.
From https://github.com/Particular/NServiceBus
 * [new ref]         refs/pull/1/head -> upstream/pr/1
 * [new ref]         refs/pull/2/head -> upstream/pr/2

And check it out:
$ git checkout pr/2
Branch pr/2 set up to track remote branch pr/2 from upstream.
Switched to a new branch 'pr/2'

A: Here're the commands that worked for me.
I'll assume that one has already cloned a repo (for e.g. pytorch ) to his/her system locally. After that some volunteer/enthusiast has contributed some code and issued a PR to the remote repository but it has not been merged into the master or any other branch yet. So,
First we'll have to do git remote add to the github remote repository:
# I've given the name `original`; you can give some other name as per your liking
$ git remote add original https://github.com/pytorch/pytorch

Then cd into the repository pytorch and then simply do:
# after this, the unmerged PR should be pulled to your local repo
$ git fetch original pull/<pull_number>/head    # 23, 123 etc.,

Now, the pending PR has been fetched into your local repo and the tip of your fetch would be in FETCH_HEAD. If you want to merge this pending PR locally, then simply do:
$ git merge FETCH_HEAD

After this, if you do:
$ git status

You should be able to see that the local repo is ahead of n commits that were part of the pending PR (i.e. it's possible to issue more than 1 commit in a single PR). So, the number of commits depend on the commits contained in the pending PR.

A: You can do this:
1) Add the upstream remote:
git remote add upstream git@github.com:Particular/NServiceBus.git

2) After that, you can checkout any pull request to a new branch per its ID:
git fetch upstream pull/PULL_REQUEST_ID/head:NEW_BRANCH_NAME

Then you'll have a branch named NEW_BRANCH_NAME containing the PR code.
Adding an alias:
If you do this as often as me, you may want to setup some aliases for it.
I have this in my .gitconfig:
[alias]
    fetch-pr = "!f(){\
        [ -z \"$1\" ] && { echo Usage: git fetch-pr PULL_REQUEST_ID [REMOTE_NAME] [NEW_BRANCH_NAME]; exit 1; }; \
        remote=${2:-origin}; \
        branch=${3:-pr-$1}; \
        git fetch $remote \"pull/$1/head:$branch\"; \
        }; f "
    pr = "!f(){\
        branch=${3:-pr-$1}; \
        git fetch-pr \"$@\"; \
        git switch $branch; \
        }; f "

With the above, I can do:
git fetch-pr 123              # fetch PR #123 into branch pr-123
git fetch-pr 123 some-branch  # fetch PR #123 into some-branch
git pr 123                    # fetch and switch to the branch

A: This is the solution from GitHub docs:
From your project repository, check out a new branch and test the changes.
git checkout -b GithubUserID-branchName branchName
git pull https://github.com/GithubUserID/reponame.git branchName

Where:

*

*GithubUserID is the username of the person who opened the pull request.

*branchName is the name of the branch for example master

*reponame the repository name like demo-todo

Example :
git checkout -b felix123-master master
git pull https://github.com/felix123/demo-todo.git master

A: If you just want to add one unmerged Pull Request from some other repo, to your own,
there is no need for all complications (as mostly shown in other answers).
Instead just go into your own repo and pull in the commit (from PR source), using its commit hash.
git pull https://bitbucket.org/SomeUser/SomeProjectRepo/commits/c15...db2

Doing it this way, you will just have a bunch of new edited files, as if you had edited them yourself. It's then up to you if you want to commit these with some tag/label.
If you then want to push all news up to your own GitHub repo, just do as always:
git commit -m "Added something by Anonymous"
git push -u origin master

A: below is to make your 'git fetch' command to fetch all pull requests when run "git fetch"
add below into ~/.gitconfig
[remote "origin"]
fetch = +refs/pull-requests/*/from:refs/remotes/origin/pr/*

note the reference "refs/pull-requests/" has the stash naming convention, for git hub, you may need different format

A: Github has clear doc for merging the pull request into a local repo:
https://help.github.com/en/articles/checking-out-pull-requests-locally
It boils down to knowing that a pull request in GitHub is just a branch in the base repo where the branch name is a sequence number. The above article shows you how to find this number and the git command line magic to pull it into your local repo with whatever branch name you'd like.
I could not find a similarly simple way to merge the pull request into a fork I created on GitHub.

A: I found this solution to this problem - pulling changes from unmerged PR on different Machine , I did following things on git bash
1. You must have taken clone of remote repository on machine 2
2. do git checkout (branch on which PR was generated)
3. do git pull
 and done!!!!!!!!!!!!!!

redpajama_set_name: RedPajamaStackExchange


Evgeny Malkin renewed an eight-year contract with the Pittsburgh Penguins. We recall the highlights of one of the world's best hockey players, from the junior Championship in Belarus to the NHL.
Evgeny Malkin, one of the best hockey players in the world, has renewed his contract with the NHL's Pittsburgh Penguins for an eight year term. RBTH recalls five highlights from Malkin's career.
The first time Evgeny Malkin proved his star potential was at the 2004 World U18 Championship, which was held in Belarus' capital of Minsk. The Russian junior players beat the Americans, 3-2, and the young Malkin became one of the top scorers of Team Russia, with 4 goals and 4 assists.
View the video: Malkin gets into his second fight of the playoffs in a match against Boston.
Even so, the Urals hockey school graduate might never have risen to stardom: In the run-up to the tournament, the forward suffered a severe head injury during a match for the Magnitogorsk Metallurg farm club.
"Right until the last minute, we were not sure whether Malkin was coming to the World Championship. Eventually, we decided to risk it and bring him over.
And even though Evgeny was not in top shape, he was named MVP of the tournament," says Andrei Shayanov, who coached the Russian junior team at the time.
Malkin's transfer to the NHL was marred by a high-profile scandal. In 2004, the Metallurg forward was picked second overall in the NHL Draft by the Pittsburgh Penguins. He was expected to start playing in the NHL in the fall of 2006.
Metallurg's managers prolonged Malkin's contract until 2008, however, despite his willingness to move overseas. In protest, Malkin left the team camp in Finland, without authorization, and headed for the United States, where he started preparing for the NHL season.
The Russian side tried to bring the player back, but, on Sept. 5, Malkin closed a deal with the Pens. The center debuted for his new club in an exhibition game against Philadelphia.
Malkin registered an assist in the first period, but he injured his back in the second, following a collision with his teammate John LeClair.
In 2009, Malkin had an extremely good season. He topped the scoring table in the regular season by securing 113 points, helping his team finish fifth overall.
In the playoff finals, the Penguins faced the Detroit Red Wings, just as they had the year before – and this time they won in a tight, 7-game series.
Apart from winning the Stanley Cup, Malkin became the first Russian to receive a Conn Smythe Trophy, which is awarded to the most valuable player in the NHL playoffs.
In 2012, Malkin became a true leader of the Penguins. In the absence of Sidney Crosby, who was disqualified for 60 games, Malkin secured his team a playoff berth by recording 108 points in the regular season.
This achievement is all the more impressive since Malkin missed most of the 2010/2011 season: He sustained a serious knee injury and had to undergo a tough recovery in the preseason.
May 2012 was the heyday of Malkin's career on the national ice hockey team. Evgeny twice fell one step short of a World Championship title – in 2005 and in 2010.
In 2012, Team Russia, staffed with the likes of Pavel Datsyuk, Semyon Varlamov and Alexander Ovechkin, swept away the competition by winning every single game of the tournament.
In the final match, Russia stunned the Slovaks, 6-2, and Malkin became MVP of the Championship.


Union Public Service Commission i.e UPSC Successfully conducted Electronics And Communication Engineering IES 2017/ESE 2017 mains exam paper on 14th May 2017. The paper was conducted in 2 shifts i.e shift 1 IES Paper 1 – EC Conventional and Shift 2 IES Paper 2 – EC Conventional.
The UPSC engineering services exam 2017 exam paper code for Electronics And Communication engineering is EC. Here we are providing you the all sets question paper and their solution in pdf format.
Only those candidates who qualified IES 2017 Electronics And Communication Engineering Prelims Exam (08 January 2017) were allowed to sit in IES 2017 Electronics And Communication Engineering Mains Exam (14 May 2017).


Welcome to the thread for Netami's Pest Control (Updated June 2018)! Netami's Pest Control is the last pest control script you'll ever need to purchase. Currently included features are below, with more always in development!
To suggest a new feature, just comment here on the thread with what you'd like to see added!
NOTE: FOR REPAIR MODE YOU MUST HAVE LOTS OF REGULAR LOGS IN BANK!
Best of luck :)! A PC script is always needed.
Would like to see a repair method. With bank support (all logs) or woodcutting support (15~ trees on Island). Bank would guarantee a win (as long as other people kill portals obviously) since you will not compete with others to chop the trees down. Also, should either walk back to boat to afk or just afk normally after repairing 10 (minimum to "contribute" to game) barriers/gates.
free trial would be cool.
Got it, works pretty well will get stuck on a brawler for a bit but its expected, can you add quick prayers options?
Also should mention the lag prevents me from getting 50 damage pretty frequently.
You got other problems, I have no lag, what do you have an OS machine?
I've got a pretty nice dell laptop with an i5 and 4 gigs of ram. It's not riddled with viruses either unless the windows I pirated was infected lol. I'm thinking it might do better once I get my combat up to the intermediate boat for a little bit longer rounds. I also think the lag *could* be my isp (maybe im DCing. Relogging feature never worked for me), but I haven't had problems with them since they had constant problems a few years ago so I'd be a bit surprised.
Maybe. I did pirate it waay back on kat so I would be a bit suprised if it was since they tend to be reliable. I will say I have foud the lag is considerably less when I keep OSBuddy open, Tribot minimized, and have a heap size of 512 for the one bot (for other bots, pc is still a bit laggy).
You aren't meant to have more than one LG client open at a time, unless you have something like a server.
Meant that as in I have only one bot running and it isn't too laggy for any script but pest control. Others usually do just fine.
maybe delete your nati pest control file and restart the script thats what i do when i get errors with any of my bots.. i just wish @Netami would respond or add in quick prayer option.
I do not plan on adding a toggle feature on the paint as it is unnecessary.
Ok thanks for the response i have other options available anyway.
script is broken after that pest control update i guess.
Pest control was updated today, fix will be coming shortly.
that is basically what i said lel.


text:
Claudien peut désigner :

Saint chrétien
 Claudien de Troyes († entre 270 et 275), ou Claude, avec Julie, vierge, et ses compagnons Juste, Jucondien (ou Jocondien ou Jucundien), et cinq autres martyrs, sous Aurélien à Troyes en Champagne ; fêtés le 21 juillet.

Autres personnalités portant ce prénom ou ce patronyme
 Claudien (° vers 370 - † vers 408), ou Claudius Claudianus, poète latin qui écrivit au tournant des  et  s.
 Claudien Mamert (), ou Mamertus Claudianus, philosophe et théologien gallo-romain, contemporain et ami de Sidoine Apollinaire.
 Robert de la Vaissière (1880-1937), poète et critique, a utilisé le pseudonyme de Claudien dans diverses revues.

Notes et références

Voir aussi

redpajama_set_name: RedPajamaWikipedia


Made with GDRY wicking so you can run, jump, and play all day.
Breathable jersey with gDry moisture wicking helps keep you cool.
Comfort seams help create smooth lines and prevent chafing.
Assorted color and print panels throughout.


By Audrick Krause. Types of car. Published at Tuesday, March 19th, 2019 05:57:13 AM.
By Adalrik Engel. Types of car. Published at Tuesday, March 19th, 2019 05:57:32 AM.
By Ame Jung. Types of car. Published at Tuesday, March 19th, 2019 05:57:44 AM.


text:
The Neighbourhood Centres
The Hatches
Seventeen small 'Hatches', groups of shops providing basic necessities, are scattered throughout the residential neighbourhoods of Harlow. In the early days of the New Town most of them had a newsagent and a greengrocer and two or three other shops such as a café or restaurant, a barber shop, a small grocers, or a bookmaker. Most of the specialist shops have been replaced with larger convenience stores. The one thing that has not changed is the proximity of a pub – almost all of which are named after an Essex butterfly.
Clifton Hatch is in the Latton Bush neighbourhood on the southern edge of Harlow. The shops located there in 1977 were typical of the time: V.A. Cooper Newsagents; Bamboo Fish Bar; Philip Water Greengrocer and Fruiterer, and Food Fayre. These have all gone, replaced by a Spar convenience store and Harlow Kebabs. Burgoyne Hatch in the Mark Hall North neighbourhood has Clippers Barbers, B & U Convenience and Wing's Garden Chinese Takeaway as well as the Purple Emperor pub. In 1994, Ward Hatch in Mark Hall South was occupied by W.H. News and Off Licence; a Mini Market and Off Licence; Harlow Quality Fish and Chicken Bar; and The White Admiral public house. The pub remains, but the other businesses have been replaced by Jad's Convenience (offering Groceries, Newsagent, Off License and Lottery) and Eat Well Chinese Takeaway.

redpajama_set_name: RedPajamaCommonCrawl


Sugaring not only removes unwanted hair but also improves the condition of the skin.
What is your preferred hair removal choice? Have you ever heard and tried sugaring hair removal method? I have put together 5 very good reasons why you should choose sugaring over waxing and will show you in short videos how it is done.
1. With strip wax the hair is removed against the natural direction of growth which may cause the hair to split causing the hair to grow back quicker. With sugaring the hair is always removed in the natural direction of growth causing less stress to the follicle, more ease of extraction of the hair thus a slower regrowth. There is a more thorough extraction of the hair when sugaring, resulting in a more effective and permanent after result compared to waxing.
2. Wax involves heat causing more pain. Sugaring contains no heat which is gentler on the skin and the hair follicle providing a more therapeutic experience causing less stress to you and your skin.
3. There is less risk of cross contamination with sugaring as there is an individual glove that is disposed of after each treatment.
4. Sugaring is a permanent reduction of hair removal where waxing isn't. The results are more permanent when the treatment is done every 2 to 3 weeks depending on the area, particularly on the face. The closer you have the treatments together the better the results.
5. Waxing adheres to fresh skin cells where as sugaring adheres to dead skin cells which makes it a natural exfoliating treatment. Sugaring helps to prevent and treat ingrown hairs where as waxing can sometimes cause ingrown hair which makes it harder to treat. There is less reaction like spots, rash, redness or inflammation after sugaring compared to waxing thus making it more suitable for pregnant women, women or men that are very sensitive.
Peaches & Lime Beauty Salon is working with Alexandria body sugaring product range which is 100% organic - comprising of lemon, sugar and water. It is hypoallergenic and non-comedogenic for the most sensitive skin.
In November 2017, Peaches & Lime beauty salon won the Sugaring Salon of the Year Award at the Alexandria Professional Awards ceremony.
I have made few videos to show you how the sugaring is done and what happens during sugaring hair removal treatment.
If you would like to find out more or if you have any questions, please get in touch with us by email: erica@peacheslime.ie or call: 01-2056709.
If you would like to book sugaring treatment, you can do it through our online booking system here!


text:
Excess of rare, inherited truncating mutations in autism
Niklas Krumm, Tychele N. Turner, Carl Baker, Laura Vives, Kiana Mohajeri, Kali Witherspoon, Archana Raja, Bradley P. Coe, Holly A. Stessman, Zong Xiao He, Suzanne M. Leal, Raphael Bernier, Evan E. Eichler
To assess the relative impact of inherited and de novo variants on autism risk, we generated a comprehensive set of exonic single-nucleotide variants (SNVs) and copy number variants (CNVs) from 2,377 families with autism. We find that private, inherited truncating SNVs in conserved genes are enriched in probands (odds ratio = 1.14, P = 0.0002) in comparison to unaffected siblings, an effect involving significant maternal transmission bias to sons. We also observe a bias for inherited CNVs, specifically for small (<100 kb), maternally inherited events (P = 0.01) that are enriched in CHD8 target genes (P = 7.4 × 10 â'3). Using a logistic regression model, we show that private truncating SNVs and rare, inherited CNVs are statistically independent risk factors for autism, with odds ratios of 1.11 (P = 0.0002) and 1.23 (P = 0.01), respectively. This analysis identifies a second class of candidate genes (for example, RIMS1, CUL7 and LZTR1) where transmitted mutations may create a sensitized background but are unlikely to be completely penetrant.
https://doi.org/10.1038/ng.3303
10.1038/ng.3303
Dive into the research topics of 'Excess of rare, inherited truncating mutations in autism'. Together they form a unique fingerprint.
Autistic Disorder Medicine & Life Sciences 100%
Nucleotides Medicine & Life Sciences 80%
Logistic Models Medicine & Life Sciences 43%
Odds Ratio Medicine & Life Sciences 43%
Maternal Inheritance Medicine & Life Sciences 42%
Krumm, N., Turner, T. N., Baker, C., Vives, L., Mohajeri, K., Witherspoon, K., Raja, A., Coe, B. P., Stessman, H. A., He, Z. X., Leal, S. M., Bernier, R., & Eichler, E. E. (2015). Excess of rare, inherited truncating mutations in autism. Nature genetics, 47(6), 582-588. https://doi.org/10.1038/ng.3303
Excess of rare, inherited truncating mutations in autism. / Krumm, Niklas; Turner, Tychele N.; Baker, Carl et al.
In: Nature genetics, Vol. 47, No. 6, 27.05.2015, p. 582-588.
Krumm, N, Turner, TN, Baker, C, Vives, L, Mohajeri, K, Witherspoon, K, Raja, A, Coe, BP, Stessman, HA, He, ZX, Leal, SM, Bernier, R & Eichler, EE 2015, 'Excess of rare, inherited truncating mutations in autism', Nature genetics, vol. 47, no. 6, pp. 582-588. https://doi.org/10.1038/ng.3303
Krumm N, Turner TN, Baker C, Vives L, Mohajeri K, Witherspoon K et al. Excess of rare, inherited truncating mutations in autism. Nature genetics. 2015 May 27;47(6):582-588. doi: 10.1038/ng.3303
Krumm, Niklas ; Turner, Tychele N. ; Baker, Carl et al. / Excess of rare, inherited truncating mutations in autism. In: Nature genetics. 2015 ; Vol. 47, No. 6. pp. 582-588.
@article{5ddaad427e094eb0ab80e48ec07cd77e,
title = "Excess of rare, inherited truncating mutations in autism",
abstract = "To assess the relative impact of inherited and de novo variants on autism risk, we generated a comprehensive set of exonic single-nucleotide variants (SNVs) and copy number variants (CNVs) from 2,377 families with autism. We find that private, inherited truncating SNVs in conserved genes are enriched in probands (odds ratio = 1.14, P = 0.0002) in comparison to unaffected siblings, an effect involving significant maternal transmission bias to sons. We also observe a bias for inherited CNVs, specifically for small (<100 kb), maternally inherited events (P = 0.01) that are enriched in CHD8 target genes (P = 7.4 × 10 {\^a}'3). Using a logistic regression model, we show that private truncating SNVs and rare, inherited CNVs are statistically independent risk factors for autism, with odds ratios of 1.11 (P = 0.0002) and 1.23 (P = 0.01), respectively. This analysis identifies a second class of candidate genes (for example, RIMS1, CUL7 and LZTR1) where transmitted mutations may create a sensitized background but are unlikely to be completely penetrant.",
author = "Niklas Krumm and Turner, {Tychele N.} and Carl Baker and Laura Vives and Kiana Mohajeri and Kali Witherspoon and Archana Raja and Coe, {Bradley P.} and Stessman, {Holly A.} and He, {Zong Xiao} and Leal, {Suzanne M.} and Raphael Bernier and Eichler, {Evan E.}",
note = "Funding Information: We thank D. Obenshain, D. Hall, B. Koser and S. Novikova for providing support for usage of the Amazon Cloud and for assistance in the deposition of SNV and CNV call sets into the National Database for Autism Research (NDAR). We are grateful to the laboratories of M. Wigler and M. State for providing early access to exome sequencing data as well as access to SNP microarray data. We also thank T. Brown for assistance in editing this manuscript. Funding for this study was provided, in part, by the US National Institutes of Health (1U01MH100233 to E.E.E.), by the National Institute for Mental Health (R01MH101221 to E.E.E. and R01MH100047 to R.B.) and by the Simons Foundation (SFARI 89368 to R.B. and SFARI 137578 to E.E.E.). E.E.E. is an investigator of the Howard Hughes Medical Institute. We are grateful to all of the families at the participating Simons Simplex Collection (SSC) sites, as well as the principal investigators (A. Beaudet, R. Bernier, J. Constantino, E. Cook, E. Fombonne, D. Geschwind, R. Goin-Kochel, E. Hanson, D. Grice, A. Klin, D. Ledbetter, C. Lord, C. Martin, D. Martin, R. Maxim, J. Miles, O. Ousley, K. Pelphrey, B. Peterson, J. Piggot, C. Saulnier, M. State, W. Stone, J. Sutcliffe, C. Walsh, Z. Warren and E. Wijsman). We appreciate obtaining access to phenotypic data on Simons Foundation Autism Research Initiative (SFARI) Base. Approved researchers can obtain the SSC population data set described in this study by applying at https://base.sfari.org/. Publisher Copyright: {\textcopyright} 2015 Nature America, Inc. All rights reserved.",
doi = "10.1038/ng.3303",
journal = "Nature Genetics",
T1 - Excess of rare, inherited truncating mutations in autism
AU - Krumm, Niklas
AU - Turner, Tychele N.
AU - Baker, Carl
AU - Vives, Laura
AU - Mohajeri, Kiana
AU - Witherspoon, Kali
AU - Raja, Archana
AU - Coe, Bradley P.
AU - Stessman, Holly A.
AU - He, Zong Xiao
AU - Leal, Suzanne M.
AU - Bernier, Raphael
AU - Eichler, Evan E.
N1 - Funding Information: We thank D. Obenshain, D. Hall, B. Koser and S. Novikova for providing support for usage of the Amazon Cloud and for assistance in the deposition of SNV and CNV call sets into the National Database for Autism Research (NDAR). We are grateful to the laboratories of M. Wigler and M. State for providing early access to exome sequencing data as well as access to SNP microarray data. We also thank T. Brown for assistance in editing this manuscript. Funding for this study was provided, in part, by the US National Institutes of Health (1U01MH100233 to E.E.E.), by the National Institute for Mental Health (R01MH101221 to E.E.E. and R01MH100047 to R.B.) and by the Simons Foundation (SFARI 89368 to R.B. and SFARI 137578 to E.E.E.). E.E.E. is an investigator of the Howard Hughes Medical Institute. We are grateful to all of the families at the participating Simons Simplex Collection (SSC) sites, as well as the principal investigators (A. Beaudet, R. Bernier, J. Constantino, E. Cook, E. Fombonne, D. Geschwind, R. Goin-Kochel, E. Hanson, D. Grice, A. Klin, D. Ledbetter, C. Lord, C. Martin, D. Martin, R. Maxim, J. Miles, O. Ousley, K. Pelphrey, B. Peterson, J. Piggot, C. Saulnier, M. State, W. Stone, J. Sutcliffe, C. Walsh, Z. Warren and E. Wijsman). We appreciate obtaining access to phenotypic data on Simons Foundation Autism Research Initiative (SFARI) Base. Approved researchers can obtain the SSC population data set described in this study by applying at https://base.sfari.org/. Publisher Copyright: © 2015 Nature America, Inc. All rights reserved.
N2 - To assess the relative impact of inherited and de novo variants on autism risk, we generated a comprehensive set of exonic single-nucleotide variants (SNVs) and copy number variants (CNVs) from 2,377 families with autism. We find that private, inherited truncating SNVs in conserved genes are enriched in probands (odds ratio = 1.14, P = 0.0002) in comparison to unaffected siblings, an effect involving significant maternal transmission bias to sons. We also observe a bias for inherited CNVs, specifically for small (<100 kb), maternally inherited events (P = 0.01) that are enriched in CHD8 target genes (P = 7.4 × 10 â'3). Using a logistic regression model, we show that private truncating SNVs and rare, inherited CNVs are statistically independent risk factors for autism, with odds ratios of 1.11 (P = 0.0002) and 1.23 (P = 0.01), respectively. This analysis identifies a second class of candidate genes (for example, RIMS1, CUL7 and LZTR1) where transmitted mutations may create a sensitized background but are unlikely to be completely penetrant.
AB - To assess the relative impact of inherited and de novo variants on autism risk, we generated a comprehensive set of exonic single-nucleotide variants (SNVs) and copy number variants (CNVs) from 2,377 families with autism. We find that private, inherited truncating SNVs in conserved genes are enriched in probands (odds ratio = 1.14, P = 0.0002) in comparison to unaffected siblings, an effect involving significant maternal transmission bias to sons. We also observe a bias for inherited CNVs, specifically for small (<100 kb), maternally inherited events (P = 0.01) that are enriched in CHD8 target genes (P = 7.4 × 10 â'3). Using a logistic regression model, we show that private truncating SNVs and rare, inherited CNVs are statistically independent risk factors for autism, with odds ratios of 1.11 (P = 0.0002) and 1.23 (P = 0.01), respectively. This analysis identifies a second class of candidate genes (for example, RIMS1, CUL7 and LZTR1) where transmitted mutations may create a sensitized background but are unlikely to be completely penetrant.
U2 - 10.1038/ng.3303
DO - 10.1038/ng.3303
JO - Nature Genetics
JF - Nature Genetics


text:
'use strict';

/**
 * Module dependencies.
 */
var users = require('../../app/controllers/users.server.controller'),
	productBrands = require('../../app/controllers/productBrands');

module.exports = function(app) {
	// ProductCategory Routes
	app.route('/productBrands')
		.get(productBrands.list)
		.post(users.requiresLogin, productBrands.create);

	app.route('/productBrands/:productBrandId')
		.get(productBrands.read)
		.put(users.requiresLogin, productBrands.hasAuthorization, productBrands.update)
		.delete(users.requiresLogin, productBrands.delete);
	// Finish by binding the productBrand middleware
	app.param('productBrandId', productBrands.productBrandByID);
};

redpajama_set_name: RedPajamaGithub


A Hindu and a Christian walked into our house. These men were not the first line of a joke but new friends—students from India now living nearby. We invited them to dinner. We ate chicken biryani together and exchanged stories of family, and travel, and curry so hot you can't breathe. We also prayed. We prayed before the meal, thanking our Lord, the giver of daily bread, and we prayed during our regular time of family worship after the meal. They were in our house for only a few hours, but they left knowing our love for them and, more importantly, our love for our Lord. Though many of us pray regularly with our spouses and children, we sometimes forego that practice when guests are in the home. If we do, we miss a valuable opportunity. Whether we're welcoming friends for coffee or hosting them for a weekend, our prayers together refresh the hearts of saints and stand as a testimony to the unconverted.
We are, perhaps, ready enough to make our guests welcome, to provide for their lodging and refreshment, to show them the wonders of our environs, and to invite friends for their entertainment; but besides this, we owe a duty to their souls.
For our believing guests, praying together provides a home away from home. They're not able to pray with their own families, so we invite them to pray with ours. Conversely, nothing could be less welcoming than sharing with guests the physical provisions of our home while thoughtlessly excluding them from its source of spiritual nourishment. Praying before mealtimes is probably the most obvious way to pray together with guests. It was certainly the practice of the early church who "received their food with glad and generous hearts" (Acts 2:46), and we shouldn't neglect it either. Every time we break bread we thank its giver, whomever our dinner companions are.
Our prayers stand as an encouragement to believing guests and a living sermon to unbelieving ones. Jesus prayed before his post-resurrection meal with two of his disciples (Luke 24:30), and Paul prayed before his shipboard meal with 200 pagan sailors (Acts 27:35–37). When the church in Acts devoted themselves to eating and praying together, "the Lord added to their number day by day those who were being saved" (Acts 2:47). Who knows what effect our sincere acknowledgment of God will have on those with whom we share a meal? We also ought to invite guests to our regular times of family prayer. This is a unique opportunity for gospel witness to unbelievers. Often in our evangelistic conversations with non-Christians, the terms of our discussion are dictated by them: "Do you really think homosexuality is a sin?" "What about abortion?" "Are you against birth control?" "What do you think about evolution, climate change, and the church's view of women?" Each of these questions presents valid issues to which the Scripture has substantive answers. But none of them is the most important issue: the responsibility of every human being to submit to the triune Lord. In our homes and at prayer, we have unique freedom to set the terms of engagement, to focus our guests on the true priorities of a Christian's heart. Having nourished our friends' bodies, we offer bread for their soul. As we pray, we proclaim to our guests—and remind ourselves!—that we are each spiritual beings who owe worship to God and approach him only through the blood of Christ. Just as the prayers of Stephen doubtless rang in the ears of Paul (Acts 7:58–60; 22:20), and then the prayers of Paul doubtless rang in the ears of the Philippian jailer (Acts 16:25, 30), the testimony of our family prayers may lead to the salvation of many. We may one day find our past dinner guests seated beside us at the great wedding feast of the Lamb. Brothers and sisters, let us pray.


The above information about Sgi-Usa, located at the address 930 Commonwealth Ave Ste 4, Boston, MA, is accurate and has been gathered from open sources. To contact the company via phone and get all the necessary information, call (617) 264-2000. You may visit the website http://www.sgi-usa.org/ to obtain additional information about the company.
Information about the company is also available by visiting on the following categories on this website: Orthodox Churches, Pentecostal Churches, Buddhist Temples, Hindu Temples, Mosques, Messianic Synagogues, Synagogues.
Near this company, there are 5 similar companies that may be of interest to you. The closest company is called Frances Jacobson Early Childhood Center and is located at a distance of 0.8364 miles; 1.3461 kilometers. The company farthest away is called Lubavitch Center and is located at a distance of 1.2049 miles; 1.9392 kilometers away.


We are delighted to share the news that Community Care North Bucks has been awarded the Queens Award for Voluntary Service 2018. This is a remarkable achievement and speaks volumes for the committed and dedicated work of all our volunteers, serving the local community week in week out.
We were nominated by a local resident last year and have been through the assessment process over the past few months: the official announcement was made on Saturday 2nd June.
A huge thank you to all of our volunteers for making this award possible – you can all feel immensely proud of the recognition this Award represents.


A new Student Volunteer Army is about to launch. This time primary school children will get to take part.
More than 32,000 students have been recruited for the new primary school programme.
Under the initiative, classrooms will carry out volunteer projects in their local community.
Student Volunteer Army founder and community entrepreneur Sam Johnson spoke to Duncan Garner.


Run to the yellow circle in time to catch the ball.
Make it around defenders using your teammates to get to the end zone. Watch out for the kicker! He will slow you down. If you don't make it to the end zone, you'll lose a possession.
Special moves will be unlocked to help you get down the field. As you go through the game, your progress is saved at each stage.
Copyright © 2015 - 2016.


Welcome to Cyprus in Focus, a pictorial journey of our move from the UK to Cyprus in 2014, and the continuing story of life on the island.
We have visited many times over the years, and fell in love with the scenery, the food, the people and the weather, so it was the obvious place to choose to live when it came to giving up the rat race.
We hope you enjoy our story.
Many thanks for sharing your Cyprus blog site…like youselves, we have been smitten by the prospect of retiring in Cyprus for some time…we lived there for 3 years in the late 90's & after numerous holidays there, we are finally taking early retirement, July 2015 & plan on moving to the Paphos area anytime from July 15. Reading you notes & anecdotes certainly reinforces our resolve to make the move. Love your photographs & see you have plenty of pics of cats…we are planning on bringing our ragdoll with us. Looking forward to following your site….
Thank you Julie & Steve. Been a bit slow keeping the blog up to date, but hope to catch up with current news soon.


text:
Q: Uninstalled Program While Running and Did Not Really Uninstall On the latest version of Windows 10, I uninstalled Audacity because I was having trouble with it and wanted to re-install it. However, I didn't realize that Audacity was open while I uninstalled it from Settings -> Storage -> Apps & features. Now, when I click on Audacity in the taskbar it still opens and runs like it did before. Is there a way to uninstall a program that no longer shows up in Settings or Control Panel? I looked in Control Panel and it was not in the list of applications/programs.
Any help would be appreciated.

A:
Audacity was open while I uninstalled it from Settings -> Storage ->
Apps & features. Now, when I click on Audacity in the taskbar it still
opens and runs like it did before. Is there a way to uninstall a
program that no longer shows up in Settings or Control Panel?

The easiest way to solve this kind of problem is to reinstall the program before trying to uninstall. This resets the uninstall capability.
Restart the computer.
Install Audacity again, and restart.
Now uninstall it while it is not running.
Now that it is working, you can install Audacity or leave uninstalled as you wish.


text:
US and Russian officials will meet in Geneva to de-escalate the tension on the Ukraine border - Tuesday 18th January 2022 05:15 PM
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Well-known farmer from Angol dies after being shot in a truck: they report that he was being persecuted | National - Tuesday 18th January 2022 05:13 PM
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Panama announced two more cases of COVID-19 after friendly with Peru - Tuesday 18th January 2022 05:12 PM
WhatsApp Azul: WhatsApp Plus: What does version 18.90.0 include, how to install the APK and what are the updates for 2022?
Technology Stephanie Technology Saturday 15th January 2022 12:49 AM REPORT
whatsapp blue A new version arrives for the blue application
All about the latest WhatsApp Plus 2022 update.
Lbinds the whatsapp plus latest update, which is already available, it is the number 18.90.0, which brings new improvements for its users.
One of the novelties is the creation of a new filter for the states, to create varied states and on a regular basis, in addition some errors that the apk presented have been corrected.
You can download the latest version of APK 18.90.0 on one of these sites:
https://idescargar.com/whatsapp-plus/
https://apkposts.com/whatsapp-plus/
https://www.malavida.com/es/soft/whatsapp-plus/android/#gref
Once it has been downloaded, you have to install it.
It must be taken into account that to be installed properly, the original WhatsApp application must be eliminated with its components.
Once installed, you need to register your phone.
So WhatsApp Plus 18.90.0 can now be used.
WhatsApp Plus is an unofficial app of the same messaging application that has unique functions as a difference. In order to update it, you need to follow these steps:
-Open WhatsApp and enter the icon with the three points at the top of the menu and enter 'WhatsApp Plus settings'
-Already inside you must look for the 'update WhatsApp Plus' function, when you press it you must follow the instructions that will appear on the screen to be able to get the update.
People who have tried this version of WhatsApp have stated thatAlthough it is an APK that is not downloaded from official application sites, it is safe.
There is no certain download page, but different sites created by users, so you are exposed to a virus.
There are other risks to not being an official app, for example, the account may be suspended and the phone locked.
The APK version of WhatsApp Plus has more features than the WhatsApp version of Facebook. It allows you to activate airplane mode, send content with a maximum size of 50 MB (for 16 MB in the original version), activate dark mode, deactivate read receipts and choose which contacts can see the read receipt, schedule messages, it has a greater number of emojis, allows you to determine an automatic message, notifies when a contact is connected, allows you to choose the color, font. The above are certain functions, which the original version of WhatsApp from Facebook does not have.
TAG: WhatsApp Azul WhatsApp version include install APK updates
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text:
Made in IBM Labs:
Collaboration aims to harness the energy of 2,000 suns
High-concentration photovoltaic thermal system able to convert 80% of collected solar energy
Zurich, 22 April 2013—Today on Earth Day, scientists have announced a collaboration to develop an affordable photovoltaic system capable of concentrating solar radiation 2,000 times and converting 80 percent of the incoming radiation into useful energy. The system can also provide desalinated water and cool air in sunny, remote locations where they are often in short supply.
A three-year, $2.4 million (2.25 million CHF) grant from the Swiss Commission for Technology and Innovation has been awarded to scientists at IBM Research (NYSE: IBM); Airlight Energy, a supplier of solar power technology; ETH Zurich (Professorship of Renewable Energy Carriers) and Interstate University of Applied Sciences Buchs NTB (Institute for Micro- and Nanotechnology MNT) to research and develop an economical High Concentration PhotoVoltaic Thermal (HCPVT) system.
Based on a study by the European Solar Thermal Electricity Association and Greenpeace International, technically, it would only take two percent of the solar energy from the Sahara Desert to supply the world's electricity needs*. Unfortunately, current solar technologies on the market today are too expensive and slow to produce, require rare Earth minerals and lack the efficiency to make such massive installations practical.
The prototype HCPVT system uses a large parabolic dish, made from a multitude of mirror facets, which are attached to a sun tracking system. The tracking system positions the dish at the best angle to capture the sun's rays, which then reflect off the mirrors onto several microchannel-liquid cooled receivers with triple junction photovoltaic chips—each 1×1 centimeter chip can convert 25–50 watts, on average, over a typical eight hour day in a sunny region.
The entire receiver combines more than 500 chips and provides 25 kilowatts of electrical power. The photovoltaic chips are mounted on micro-structured layers that pipe liquid coolants within a few tens of micrometers off the chip to absorb the heat and draw it away 10 times more effective than with passive air cooling.
The coolant maintains the chips almost at the same temperature for a solar concentration of 2,000 times and can keep them at safe temperatures up to a solar concentration of 5,000 times.
The direct cooling solution with very small pumping power is inspired by the hierarchical branched blood supply system of the human body and has been already tested by IBM scientists in high performance computers, including Aquasar. An initial demonstrator of the multi-chip receiver was developed in a previous collaboration between IBM and the Egypt Nanotechnology Research Center.
"We plan to use triple-junction photovoltaic cells on a micro-channel cooled module which can directly convert more than 30 percent of collected solar radiation into electrical energy and allow for the efficient recovery of an additional 50 percent waste heat," said Bruno Michel, manager, advanced thermal packaging at IBM Research. "We believe that we can achieve this with a very practical design that is made of lightweight and high strength concrete, which is used in bridges, and primary optics composed of inexpensive pneumatic mirrors—it's frugal innovation, but builds on decades of experience in microtechnology.
"The design of the system is elegantly simple," said Andrea Pedretti, chief technology officer at Airlight Energy. "We replace expensive steel and glass with low cost concrete and simple pressurized metalized foils. The small high-tech components, in particular the microchannel coolers and the molds, can be manufactured in Switzerland with the remaining construction and assembly done in the region of the installation. This leads to a win–win situation where the system is cost competitive and jobs are created in both regions."
The solar concentrating optics will be developed by ETH Zurich. "Advanced ray-tracing numerical techniques will be applied to optimize the design of the optical configuration and reach uniform solar fluxes exceeding 2,000 suns at the surface of the photovoltaic cell," said Aldo Steinfeld, Professor at ETH Zurich.
With such a high concentration and a radically low cost design scientists believe they can achieve a cost per aperture area below $250 per square meter, which is three times lower than comparable systems. The levelized cost of energy will be less than 10 cents per kilowatt hour (kWh). For comparison, feed in tariffs for electrical energy in Germany are currently still larger than 25 cents per kWh and production cost at coal power stations are around 5–10 cents per kWh.
Water desalination and cool air
Current concentration photovoltaic systems only collect electrical energy and dissipate the thermal energy to the atmosphere. With the HCPVT packaging approach scientists can both eliminate the overheating problems of solar chips while also repurposing the energy for thermal water desalination and adsorption cooling.
To capture the medium grade heat IBM scientists and engineers are utilizing an advanced technology they developed for water-cooled high performance computers, including Aquasar and SuperMUC. With both computers water is used to absorb heat from the processor chips, which is then used to provide space heating for the facilities.
"Microtechnology as known from computer chip manufacturing is crucial to enable such an efficient thermal transfer from the photovoltaic chip over to the cooling liquid," said André Bernard, head of the MNT Institute at NTB Buchs. "And by using innovative ways to fabricate these heat transfer devices we aim at a cost-efficient production."
In the HCPVT system, instead of heating a building, the 90 degree Celsius water will be used to heat salty water that then passes through a porous membrane distillation system where it is vaporized and desalinated. Such a system could provide 30–40 liters of drinkable water per square meter of receiver area per day, while still generating electricity with a more than 25 percent yield or two kilowatt hours per day—a little less than half the amount of water the average person needs per day according to the United Nations**, but a large installation could provide enough water for a town.
Remarkably, the HCPVT system can also provide air conditioning by means of a thermal driven adsorption chiller. An adsorption chiller is a device that converts heat into cooling via a thermal cycle applied to an absorber made from silica gel, for example. Adsorption chillers, with water as working fluid, can replace compression chillers, which stress electrical grids in hot climates and contain working fluids that are harmful to the ozone layer.
Scientists envision the HCPVT system providing sustainable energy and potable water to locations around the world including southern Europe, Africa, Arabic peninsula, the southwestern part of the United States, South America, and Australia. Remote tourism locations are also an interesting market, particularly resorts on small islands, such as the Maldives, Seychelles and Mauritius, since conventional systems require separate units, with consequent loss in efficiency and increased cost.
A prototype of the HCPVT system is currently being tested at IBM Research – Zurich. Additional prototypes will be built in Biasca and Rueschlikon, Switzerland as part of the collaboration.
*Concentrating Solar Power: Outlook 2009 published by Greenpeace International, SolarPACES and European Solar Thermal Electricity Association
**http://www.un.org/en/globalissues/water/
About AIRLIGHT ENERGY
AIRLIGHT ENERGY is a private Swiss company based in Biasca that supplies proprietary technology for large-scale production of electricity using solar power and for energy storage. AIRLIGHT ENERGY has developed an innovative and complete solution for the markets of Concentrated Solar Power (CSP).
About ETH Zurich
ETH Zurich is one of the leading international universities for technology and the natural sciences. It is well-known for its excellent education, ground-breaking fundamental research and for putting its new findings directly into practice. Founded in 1855, ETH Zurich today has some 18,000 students from over 100 different countries, 3,800 of whom are doctoral students. It offers researchers an inspiring working environment and its students a comprehensive education. 21 Nobel Laureates have studied, taught or conducted research at ETH Zurich, underlining the excellent reputation of the institute.
Grit Abe
Chris Sciacca
Images to this press release


text:
Q: How To Develop React Node Application For The Shopify Online Store(Not for the merchant page)? This is an odd question. I couldn't find any resource relating to developing a react app and integrating it into the online store(not the merchant page).
https://shopify.dev/apps/getting-started/create, this link only discusses developing an app and integrating it into the Shopify merchant page, not on the online store.
I have gone through the documentation on the above link but could not find anything relevant.
Also, check this link https://shopify.dev/apps/online-store, but creating theme extensions is not what I want as I want to develop a full-fledged application like https://apps.shopify.com/tolstoy
Can you guys point me to the right resource?
thanks

A: Shopify is HTML, CSS and Javascript. There is nothing stopping you from making the merchant end of things ANYTHING you want. Get yourslf a Storefront API token and you're good to go.
As for a lack of resources? HTML, CSS and Javascript are 90% of your journey covered by a bazillion resources including StackOverflow. Shopify documents Storefront API fine too. What more could you ask for?


text:
St Helena Coffee - English French - Contents -
St Helena Coffee - EnglishFrench
- Contents -
Language / Welcome / Coffee Profile / History / Origins / Napoleon / Coffee of St Helena / Contact Us
St Helena & Napoleon
Napoleon arrived on St Helena on 16 October 1815 after the defeat that summer by the British and Prussians at Waterloo. The likelihood of his escaping was as remote as the island itself. The fortifications were truly formidable: gun emplacements bristled from every strategic point overlooking the ocean, and the lessons of the Dutch invasion had been learnt, so that inland passes were covered from the heights. One first-time visitor reported: 'Batteries now appear In every direction; guns, gates, embrasures, and soldiers continually meet the eye.' St Helena was in effect an impregnable ship of the line permanently at anchor in the South Atlantic.
Although the coffee plants that had been planted from the Yemeni seeds nearly a hundred years previously had disappeared from sight until Roxburgh's report in 1814, there is an apocryphal report that during his exile Napoleon said: 'The only good thing about St Helena is the coffee.'
A Regular Coffee Drinker
Despite his general indifference to food, Napoleon was a regular coffee drinker whilst on St Helena, taking it daily with breakfast at six and after lunch at ten. Dinner at eight always finished with coffee served from a silver pot in his much prized cups, commissioned by him from the Sevres porcelain factory in 1806. These were small, blue, and decorated with gold hieroglyphs and handpainted pictures taken from Scenes of Egypt by Vivant Denon. The cups had been noted by Bingham: 'The dessert service was Sevreschina, with gold knives, forks and spoons. The coffee cups were the most beautiful I have ever seen: on each cup was an Egyptian scene, and on the saucer the portrait of a bey or other distinguished person. In France they cost, one cup and saucer, twenty-five guineas.'
On a visit to the house of one of his aides, Marechal Bertrand, near St Matthew's vicarage, close by Mount Pleasant, Betsy Balcombe, accompanied by Napoleon, drank 'delectable coffee' prepared by La Pages, but gives no hint as to its origins.
Bamboo Hedge for the Emperor
Mount Pleasant is in the Sandy Bay area of the island and within five hundred yards of Bamboo Hedge, which is where the original coffee from Yemen was planted in the 1730s and which is one of Solomon's growing areas (and is now the central farm for St Helenian coffee cultivation). It is tempting to suppose that Sir William would have told Napoleon about this old coffee plantation, which is in sight of his house; and that, he might even have prepared the coffee from Bamboo Hedge for the Emperor.
Although St Helena was still in the possession of the East India Company, during Napoleon's exile its government was taken over by the Crown, which also paid for the vastly increased expenditure necessary to keep the island in a constant state of high alert.
Curiously, despite the frequent mentions of Napoleon's coffee-drinking on St Helena, there are no references to coffee amongst the detailed accounts of deliveries of food and wine to Longwood with the exception of an incident when Hudson Lowe made a gift of coffee to the Emperor, which played a part in their falling out at their second meeting in April 1816. By then a considerable agenda had built up. It is not certain where the coffee came from and although it is tempting to assume it was from the plants that had lately been seen at Sandy Bay, Montholon asserts that Lowe had received it from Reunion, the small French island in the Indian Ocean. On the face of it, that would seem unlikely as East Indiamen rarely called there, and French ships would not have been welcome on St Helena. However, Reunion coffee was at that time being sold in significant quantities at the Cape, and there was a flourishing private trade between the island and Cape Town. It is thus perfectly possible that on this occasion coffee from Reunion did find its way to St Helena and on, via Lowe, to Longwood.
Napoleon a Brief Gardener
Napoleon briefly took up gardening, built a Chinese Tea House, and planted coffee bushes as the centrepiece of what became known as Marchand's Garden, outside the Emperor's bedroom. The coffee bushes wilted in the winds, and died along with Napoleon's enthusiasm and, soon after, the man himself. The cause of death is still much disputed, although stomach cancer remains the official explanation. While arsenic has indeed been found in samples of Napoleon's hair from St Helena, it also exists for unexplained reasons in samples from as early as 1805, as well as in the hair of his three sisters, which rather undermines any suspicion that Napoleon was poisoned on the island.
A few days before the end, Marechal Bertrand recorded that Napoleon kept begging for coffee and that his new 'doctor', Antommarchi (he was in fact a dissecting room assistant), allowed him a few spoonfuls. Then, as the Emperor declined further, Bertrand writes:
"That morning, he had asked twenty times if he could be allowed some coffee. 'No, Sire', 'Might the doctors allow me just a spoonful?' 'No, Sire, not at the moment, your stomach is too irritated, you would vomit a little earlier, perhaps.' He had already vomited perhaps nine times during the day. What a great change had overtaken him! Tears came to my eyes, seeing this formidable man, who had commanded with such authority, in a manner so absolute, beg for a spoonful of coffee, seek permission, obedient as a child, asking again and again for permission and not obtaining it, without ever losing his temper. At other times during his illness, he would have thrown his doctors out, flouted their advice and done as he wanted. Now he was as docile as a child. So, here is the great Napoleon: pitiful, humble."
Napoleons Death
Napoleon died at 5:49 in the evening On 5 May 1821 in his camp bed, which had been moved to the drawing-room at Longwood. On his death, the Emperor had directed that 'I desire that my ashes should rest on the banks of the Seine, amid the French people whom I have so loved.' However, the British considered his body to be a threat to national security: Lord Rosebery remarked that 'The arrival of a dead Napoleon in Europe would be second only in embarrassment to the arrival of the living.' So he was condemned to a further exile post mortem. A burial site was selected for him situated in a pretty valley close to Hutt's Gate, by a spring from which he had always insisted that his personal drinking water at Longwood be drawn: coincidentally, it was called the Sane Valley. The funeral took place with all due pomp and ceremony, the route' lined with every member of the 3000 man garrison. The hills resounded to the boom of cannon from ship and shore, and a band played solemn martial music. After the burial, the young willow trees surrounding the grave were stripped of leaves and twigs by souvenir hunters.
Includes excerpts from an edited version of Antony Wild's book, 'Coffee: A Dark History':
To purchase Antony Wild's book, 'Coffee: A Dark History', please visit www.amazon.co.uk
St Helena Trading (UK) Limited
78 Cardiff Pl,
Bassingbourn, England, SG8 5LR,
(0)203 242 0936 sales@st-helena-coffee.com
Sea Island CoffeeSolomon & Company (St Helena) PlcLanguageEnglishFrenchGalleryContents


text:
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High 101°
Funding deal announced for Oklahoma Highway Patrol academy
Posted 9:49 pm, May 25, 2017, by Bill Miston, Updated at 10:12PM, May 25, 2017
OKLAHOMA CITY - After two years without an academy class to replace the ranks of the Oklahoma Highway Patrol, a funding deal will add approximately 30 troopers to the roads in 2018.
"Without the (Oklahoma Turnpike Authority) we wouldn't be able to pull this off," said Department of Public Safety Commissioner Michael Thompson.
Thompson made the comments at a press conference with legislators, Oklahoma Highway Patrol and the Oklahoma Turnpike Authority (OTA) officials late Thursday afternoon.
Instead of being funded through the state budget, OTA will provide $5 million to go towards an Oklahoma Highway Patrol academy, starting early next year.
"This academy will help us to actually put some troopers on the roadway in 2018," said OHP Patrol Chief, Col. Ricky Adams. "Enough to at least keep us at a stable level through this crisis we're doing right now."
DPS says perfect staffing levels of the OHP -- from the commissioner to troopers -- is 1,104; minimum staffing levels are 950, but current staffing levels are at 790, with more out the door next year because of retirement. Of the current troopers, 26 percent can retire at any time.
"Staffing wise, we've got some glaring needs across the state of Oklahoma," said Thompson, "But this Oklahoma Turnpike Authority offer to us is going to help us tremendously."
The $5 million from the OTA will go towards training and outfitting troopers in their first year, a cost of more than $157,000 per trooper.
Last year the OTA funded a trooper academy class of about 30 troopers, but all went to work on the turnpikes.
"The ability to assist with the academy, to ensure that we can maintain that strong presence for the future is important to us and it's important to the state and we're just happy to be a part of it," said OTA Executive Director Tim Gatz.
A full academy class costs about $8.4 million. The last general OHP class was in 2015. The 2018 class, Thompson says, has no strings attached.
"We're going to put the troopers where we need them," he said.
Beset by the state's budget woes and revenue failures, the OHP has had to cut back on miles driven by troopers and reduce often unseen services as the state faces an $878 million budget shortfall.
Thompson says if a budget is passed with the current estimated funding levels -- an increase of more than seven percent from last year -- the cost-savings measures will be lifted.
But it's unclear if money will be appropriated in the future to have another class in 2019.
Do you have a story you want KFOR to investigate? Click here to email us the details.
Oklahoma woman receives suspended sentence for fatal crash
Police: Norman educator arrested after being accused of drugging, raping woman
Standoff suspect surrenders for hamburger in Pottawatomie County
Public meeting scheduled for Tulsa Race Massacre mass grave search
Police searching for man accused of stealing merchandise from adult novelty store
ZZ Top set to perform in Tulsa this November
Wildlife department confirms 30th mountain lion report in Oklahoma
Blackmailing charge dismissed in case against former OHP captain
Woman arrested after allegedly crashing into OHP trooper's vehicle, leading authorities on chase
Suspect in custody after high-speed chase through Oklahoma City
OHP: Woman killed in single-vehicle crash in Cotton County
Truck driver charged with manslaughter after boulder kills 2 women
Oklahoma Highway Patrol seeking information in fatal hit-and-run
Watch: Driver hits semi, another car after failing to yield on Oklahoma turnpike
"You're going to kill somebody tonight," Trooper arrests drunk driver heading wrong way on turnpike
OHP: 2 people killed in southern Oklahoma road rage collision
OHP searching for missing Arkansas man in Arkansas River
Wanted fugitive accused of home repair fraud in custody
Harrah couple argues worth of land taken for the Eastern Oklahoma Turnpike in court
"It was just a terrible accident," Man dies after driving off interstate, crashing into home
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The total donations (above Rs 20,000) declared by the national parties was Rs 469.89 crore, from 4,201 donations, revealed a report by Association for Democratic Reforms (ADR). The report gives the details of donations received by seven national parties: Bharatiya Janata Party (BJP), Indian National Congress (INC), Bahujan Samaj Party (BSP), Nationalist Congress Party (NCP), Communist Party of India (CPI), Communist Party of India (Marxist) (CPM) and All India Trinamool Congress (AITC) in the financial year 2017-18.
BJP has topped the list declaring donations which are 12 times more than the total donations received by other national parties.
- BJP collected a total of Rs 437.04 crores from 2,977 donations above Rs 20,000, while INC collected Rs 26.658 crores from 777 donations above Rs 20,000 in FY 2017-18.
- BSP stated that the party did not receive any donations above Rs 20,000 during FY 2017-18, as it has been declaring for the past 12 years.
- NCP received 42 donations above Rs 20,000 declaring a total amount of Rs. 2.087 crores while CPM collected Rs 2.756 crores from 196 donations and CPI received Rs 1.146 crores from 176 donations.
- The total number of donations received by national parties dropped by 20 percent or Rs 119.49 crore from the previous financial year, 2016-17. The total amount of donations received in the previous financial year was Rs 589.38 crore, from 2,123 donations.
- BJP's total donations above Rs 20,000 decreased by 18 percent or Rs 95.23 crore from FY 2016-17 while INC's donations dropped by 36 percent or Rs 15.25 crore from FY 2016-17.
- A total of 89 percent or 1,361 donations (Rs 422.04 crores) were made by corporate/business sector in FY 2017-18 out of which 1,207 donations (Rs 400.23 crore) were for the BJP while 53 donations (Rs 19.29 crores) were for the INC.
- A total of 10.03 percent or 2,772 individual donors (Rs 47.12 crores) were made in FY 2017-18 out of which 1,759 individual donors donations (Rs 36.71) were made for BJP and 724 individual donors donations (Rs 7.36 crores) were made for INC.
- The top two donations received by BJP were from Prudent Electoral Trust (Rs 154.30 crores) and Ab General Electoral Trust (Rs 12.50 crores), while the top two donations received by INC were from Prudent Electoral Trust (Rs 10 crores) and Candila Health Care Ltd (Rs 2 crores).


Design for the Real World is often tipped in design circles as one of the best overall guides to ethical design theory and practice, along with Donald Norman's The Design of Everyday Things. Victor Papanek takes a radically user-centred approach to design, with a very strong emphasis on social and ecological consciousness. It's obvious to see why a book like this becomes a standard text – because all his questions are very fundamental. Essentially, he bases his design judgements on political criteria. What does this object do? Who is it for? What is it made of? And do the answers to these questions have any social consequences for the rest of society?
These square abstractions painted in shrill primaries were almost impossible to sit in; they were extremely uncomfortable. Sharp corners ripped clothing, and the entire zany construction bore no relation to the human body … The thronelike Glasgow chairs designed by Charles Rennie MacIntosh in 1902 – with six-and-one-half-foot ladderbacks [had] all the soft comforts of an orange crate.
You won't get lots of ideas for fancy new designs, but you will get a radical method and a critical approach to design which means you will never look at a spoon or a sports car in the same way again.
En route he offers scathing analyses of multinational corporations such as fast food chains and motor car manufacturers for their often selfish and profligate policies. There's a detailed critique of MacDonald's packaging waste, and a clear link argued between gas-guzzling car design and US foreign policy in the middle-East. These ideas will appeal to anybody who wishes to combine design with an ecological conscience.
Because in any reasonably conducted home, alarm-clocks seldom travel through the air at speeds approaching five hundred miles per hour, streamlining clocks is out of place.
If there's a weakness, it's that he spends a lot of time spelling out the problems of people with physical and social disabilities and calling for design solutions to them. We would all agree that these issues need attention, but personally I would rather he explained the principles of good design.
He's fairly unrelenting in his argument for ecologically sound, labour-saving devices to help the underprivileged of the third world, but few of them seem entirely convincing, even when they pass prototyping.
The latter part of the book takes on the issue of design and education. Here he makes an argument for what he calls integrated design – working in teams, tackling real problems (not fashion-related) and keeping an ethical vision in mind.
The main trouble with design schools seems to be that they teach too much design and not enough about the ecological, social, economic, and political environment in which design takes place.
If you are serious about product design, put this book on your reading list. It's full of attitude, full of ideas, and uncompromising in its approach. And it's got a very good series of bibliographies on all topics related to the issues he discusses.


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text:
namespace hayai
{
    /// Benchmarking execution controller singleton.
    class Benchmarker
    {
    public:
        /// Get the singleton instance of @ref Benchmarker.

        /// @returns a reference to the singleton instance of the
        /// benchmarker execution controller.
        static Benchmarker& Instance()
        {
            static Benchmarker singleton;
            return singleton;
        }

        /// Register a test with the benchmarker instance.

        /// @param fixtureName Name of the fixture.
        /// @param testName Name of the test.
        /// @param runs Number of runs for the test.
        /// @param iterations Number of iterations per run.
        /// @param testFactory Test factory implementation for the test.
        /// @returns a pointer to a @ref TestDescriptor instance
        /// representing the given test.
        static TestDescriptor* RegisterTest(
            const char* fixtureName,
            const char* testName,
            std::size_t runs,
            std::size_t iterations,
            TestFactory* testFactory,
            TestParametersDescriptor parameters
        )
        {
            // Determine if the test has been disabled.
            static const char* disabledPrefix = "DISABLED_";
            bool isDisabled = ((::strlen(testName) >= 9) &&
                               (!::memcmp(testName, disabledPrefix, 9)));

            if (isDisabled)
                testName += 9;

            // Add the descriptor.
            TestDescriptor* descriptor = new TestDescriptor(fixtureName,
                                                            testName,
                                                            runs,
                                                            iterations,
                                                            testFactory,
                                                            parameters,
                                                            isDisabled);

            Instance()._tests.push_back(descriptor);

            return descriptor;
        }

        /// Add an outputter.

        /// @param outputter Outputter. The caller must ensure that the
        /// outputter remains in existence for the entire benchmark run.
        static void AddOutputter(Outputter& outputter)
        {
            Instance()._outputters.push_back(&outputter);
        }

        /// Apply a pattern filter to the tests.

        /// --gtest_filter-compatible pattern:
        ///
        /// https://code.google.com/p/googletest/wiki/AdvancedGuide
        ///
        /// @param pattern Filter pattern compatible with gtest.
        static void ApplyPatternFilter(const char* pattern)
        {
            Benchmarker& instance = Instance();

            // Split the filter at '-' if it exists.
            const char* const dash = strchr(pattern, '-');

            std::string positive;
            std::string negative;

            if (dash == NULL)
                positive = pattern;
            else
            {
                positive = std::string(pattern, dash);
                negative = std::string(dash + 1);
                if (positive.empty())
                    positive = "*";
            }

            // Iterate across all tests and test them against the patterns.
            std::size_t index = 0;
            while (index < instance._tests.size())
            {
                TestDescriptor* desc = instance._tests[index];

                if ((!FilterMatchesString(positive.c_str(),
                                          desc->CanonicalName)) ||
                    (FilterMatchesString(negative.c_str(),
                                         desc->CanonicalName)))
                {
                    instance._tests.erase(
                        instance._tests.begin() +
                        std::vector<TestDescriptor*>::difference_type(index)
                    );
                    delete desc;
                }
                else
                    ++index;
            }
        }

        /// Run all benchmarking tests.
        static void RunAllTests()
        {
            ConsoleOutputter defaultOutputter;
            std::vector<Outputter*> defaultOutputters;
            defaultOutputters.push_back(&defaultOutputter);

            Benchmarker& instance = Instance();
            std::vector<Outputter*>& outputters =
                (instance._outputters.empty() ?
                 defaultOutputters :
                 instance._outputters);

            // Get the tests for execution.
            std::vector<TestDescriptor*> tests = instance.GetTests();

            const std::size_t totalCount = tests.size();
            std::size_t disabledCount = 0;

            std::vector<TestDescriptor*>::const_iterator testsIt =
                tests.begin();

            while (testsIt != tests.end())
            {
                if ((*testsIt)->IsDisabled)
                    ++disabledCount;
                ++testsIt;
            }

            const std::size_t enabledCount = totalCount - disabledCount;

            // Calibrate the tests.
            const CalibrationModel calibrationModel = GetCalibrationModel();

            // Begin output.
            for (std::size_t outputterIndex = 0;
                 outputterIndex < outputters.size();
                 outputterIndex++)
                outputters[outputterIndex]->Begin(enabledCount, disabledCount);

            // Run through all the tests in ascending order.
            std::size_t index = 0;

            while (index < tests.size())
            {
                // Get the test descriptor.
                TestDescriptor* descriptor = tests[index++];

                // Check if test matches include filters
                if (instance._include.size() > 0)
                {
                    bool included = false;
                    std::string name =
                        descriptor->FixtureName + "." +
                        descriptor->TestName;

                    for (std::size_t i = 0; i < instance._include.size(); i++)
                    {
                        if (name.find(instance._include[i]) !=
                            std::string::npos)
                        {
                            included = true;
                            break;
                        }
                    }

                    if (!included)
                        continue;
                }

                // Check if test is not disabled.
                if (descriptor->IsDisabled)
                {
                    for (std::size_t outputterIndex = 0;
                         outputterIndex < outputters.size();
                         outputterIndex++)
                        outputters[outputterIndex]->SkipDisabledTest(
                            descriptor->FixtureName,
                            descriptor->TestName,
                            descriptor->Parameters,
                            descriptor->Runs,
                            descriptor->Iterations
                        );

                    continue;
                }

                // Describe the beginning of the run.
                for (std::size_t outputterIndex = 0;
                     outputterIndex < outputters.size();
                     outputterIndex++)
                    outputters[outputterIndex]->BeginTest(
                        descriptor->FixtureName,
                        descriptor->TestName,
                        descriptor->Parameters,
                        descriptor->Runs,
                        descriptor->Iterations
                    );

                // Execute each individual run.
                std::vector<uint64_t> runTimes(descriptor->Runs);
                uint64_t overheadCalibration =
                    calibrationModel.GetCalibration(descriptor->Iterations);

                std::size_t run = 0;
                while (run < descriptor->Runs)
                {
                    // Construct a test instance.
                    Test* test = descriptor->Factory->CreateTest();

                    // Run the test.
                    uint64_t time = test->Run(descriptor->Iterations);

                    // Store the test time.
                    runTimes[run] = (time > overheadCalibration ?
                                     time - overheadCalibration :
                                     0);

                    // Dispose of the test instance.
                    delete test;

                    ++run;
                }

                // Calculate the test result.
                TestResult testResult(runTimes, descriptor->Iterations);

                // Describe the end of the run.
                for (std::size_t outputterIndex = 0;
                     outputterIndex < outputters.size();
                     outputterIndex++)
                    outputters[outputterIndex]->EndTest(
                        descriptor->FixtureName,
                        descriptor->TestName,
                        descriptor->Parameters,
                        testResult
                    );

            }

            // End output.
            for (std::size_t outputterIndex = 0;
                 outputterIndex < outputters.size();
                 outputterIndex++)
                outputters[outputterIndex]->End(enabledCount,
                                                disabledCount);
        }

        /// List tests.
        static std::vector<const TestDescriptor*> ListTests()
        {
            std::vector<const TestDescriptor*> tests;
            Benchmarker& instance = Instance();

            std::size_t index = 0;
            while (index < instance._tests.size())
                tests.push_back(instance._tests[index++]);

            return tests;
        }

        /// Shuffle tests.

        /// Randomly shuffles the order of tests.
        static void ShuffleTests()
        {
            Benchmarker& instance = Instance();
            std::random_shuffle(instance._tests.begin(),
                                instance._tests.end());
        }
    private:
        /// Calibration model.

        /// Describes a linear calibration model for test runs.
        struct CalibrationModel
        {
        public:
            CalibrationModel(std::size_t scale,
                             uint64_t slope,
                             uint64_t yIntercept)
                :   Scale(scale),
                    Slope(slope),
                    YIntercept(yIntercept)
            {

            }

            /// Scale.

            /// Number of iterations per slope unit.
            const std::size_t Scale;

            /// Slope.
            const uint64_t Slope;

            /// Y-intercept;
            const uint64_t YIntercept;

            /// Get calibration value for a run.
            int64_t GetCalibration(std::size_t iterations) const
            {
                return YIntercept + (iterations * Slope) / Scale;
            }
        };

        /// Private constructor.
        Benchmarker()
        {

        }

        /// Private destructor.
        ~Benchmarker()
        {
            // Release all test descriptors.
            std::size_t index = _tests.size();
            while (index--)
                delete _tests[index];
        }

        /// Get the tests to be executed.
        std::vector<TestDescriptor*> GetTests() const
        {
            std::vector<TestDescriptor*> tests;

            std::size_t index = 0;
            while (index < _tests.size())
                tests.push_back(_tests[index++]);

            return tests;
        }

        /// Test if a filter matches a string.

        /// Adapted from gtest. All rights reserved by original authors.
        static bool FilterMatchesString(const char* filter,
                                        const std::string& str)
        {
            const char *patternStart = filter;

            while (true)
            {
                if (PatternMatchesString(patternStart, str.c_str()))
                    return true;

                // Finds the next pattern in the filter.
                patternStart = strchr(patternStart, ':');

                // Returns if no more pattern can be found.
                if (!patternStart)
                    return false;

                // Skips the pattern separater (the ':' character).
                patternStart++;
            }
        }

        /// Test if pattern matches a string.

        /// Adapted from gtest. All rights reserved by original authors.
        static bool PatternMatchesString(const char* pattern, const char *str)
        {
            switch (*pattern)
            {
            case '\0':
            case ':':
                return (*str == '\0');
            case '?':  // Matches any single character.
                return ((*str != '\0') &&
                        (PatternMatchesString(pattern + 1, str + 1)));
            case '*':  // Matches any string (possibly empty) of characters.
                return (((*str != '\0') &&
                         (PatternMatchesString(pattern, str + 1))) ||
                        (PatternMatchesString(pattern + 1, str)));
            default:
                return ((*pattern == *str) &&
                        (PatternMatchesString(pattern + 1, str + 1)));
            }
        }

        /// Get calibration model.

        /// Returns an average linear calibration model.
        static CalibrationModel GetCalibrationModel()
        {
            // We perform a number of runs of varying iterations with an empty
            // test body. The assumption here is, that the time taken for the
            // test run is linear with regards to the number of iterations, ie.
            // some constant overhead with a per-iteration overhead. This
            // hypothesis has been manually validated by linear regression over
            // sample data.
            //
            // In order to avoid losing too much precision, we are going to
            // calibrate in terms of the overhead of some x n iterations,
            // where n must be a sufficiently large number to produce some
            // significant runtime. On a high-end 2012 Retina MacBook Pro with
            // -O3 on clang-602.0.53 (LLVM 6.1.0) n = 1,000,000 produces
            // run times of ~1.9 ms, which should be sufficiently precise.
            //
            // However, as the constant overhead is mostly related to
            // retrieving the system clock, which under the same conditions
            // clocks in at around 17 ms, we run the risk of winding up with
            // a negative y-intercept if we do not fix the y-intercept. This
            // intercept is therefore fixed by a large number of runs of 0
            // iterations.
            ::hayai::Test* test = new Test();

#define HAYAI_CALIBRATION_INTERESECT_RUNS 10000

#define HAYAI_CALIBRATION_RUNS 10
#define HAYAI_CALIBRATION_SCALE 1000000
#define HAYAI_CALIBRATION_PPR 6

            // Determine the intercept.
            uint64_t
                interceptSum = 0,
                interceptMin = std::numeric_limits<uint64_t>::min(),
                interceptMax = 0;

            for (std::size_t run = 0;
                 run < HAYAI_CALIBRATION_INTERESECT_RUNS;
                 ++run)
            {
                uint64_t intercept = test->Run(0);
                interceptSum += intercept;
                if (intercept < interceptMin)
                    interceptMin = intercept;
                if (intercept > interceptMax)
                    interceptMax = intercept;
            }

            uint64_t interceptAvg =
                interceptSum / HAYAI_CALIBRATION_INTERESECT_RUNS;

            // Produce a series of sample points.
            std::vector<uint64_t> x(HAYAI_CALIBRATION_RUNS *
                                    HAYAI_CALIBRATION_PPR);
            std::vector<uint64_t> t(HAYAI_CALIBRATION_RUNS *
                                    HAYAI_CALIBRATION_PPR);

            std::size_t point = 0;

            for (std::size_t run = 0; run < HAYAI_CALIBRATION_RUNS; ++run)
            {
#define HAYAI_CALIBRATION_POINT(_x)                                     \
                x[point] = _x;                                          \
                t[point++] =                                            \
                    test->Run(_x * std::size_t(HAYAI_CALIBRATION_SCALE))

                HAYAI_CALIBRATION_POINT(1);
                HAYAI_CALIBRATION_POINT(2);
                HAYAI_CALIBRATION_POINT(5);
                HAYAI_CALIBRATION_POINT(10);
                HAYAI_CALIBRATION_POINT(15);
                HAYAI_CALIBRATION_POINT(20);

#undef HAYAI_CALIBRATION_POINT
            }

            // As we have a fixed y-intercept, b, the optimal slope for a line
            // fitting the sample points will be
            // $\frac {\sum_{i=1}^{n} x_n \cdot (y_n - b)}
            //  {\sum_{i=1}^{n} {x_n}^2}$.
            uint64_t
                sumProducts = 0,
                sumXSquared = 0;

            std::size_t p = x.size();
            while (p--)
            {
                sumXSquared += x[p] * x[p];
                sumProducts += x[p] * (t[p] - interceptAvg);
            }

            uint64_t slope = sumProducts / sumXSquared;

            delete test;

            return CalibrationModel(HAYAI_CALIBRATION_SCALE,
                                    slope,
                                    interceptAvg);

#undef HAYAI_CALIBRATION_INTERESECT_RUNS

#undef HAYAI_CALIBRATION_RUNS
#undef HAYAI_CALIBRATION_SCALE
#undef HAYAI_CALIBRATION_PPR
        }

        std::vector<Outputter*> _outputters; ///< Registered outputters.
        std::vector<TestDescriptor*> _tests; ///< Registered tests.
        std::vector<std::string> _include; ///< Test filters.
    };
}
#endif