text:
nature chemical biology
Structural and genomic decoding of human and plant myristoylomes reveals a definitive recognition pattern
Benoit Castrec1 na1,
Cyril Dian ORCID: orcid.org/0000-0002-6349-39011 na1,
Sarah Ciccone ORCID: orcid.org/0000-0003-2529-24281,
Coralie L. Ebert1 nAff4,
Willy V. Bienvenut ORCID: orcid.org/0000-0003-4192-39201,
Jean-Pierre Le Caer ORCID: orcid.org/0000-0002-9668-47472,
Jean-Marc Steyaert3,
Carmela Giglione ORCID: orcid.org/0000-0002-7475-15581 &
Thierry Meinnel ORCID: orcid.org/0000-0001-5642-86371
Nature Chemical Biology volume 14, pages671–679(2018)Cite this article
Post-translational modifications
An organism's entire protein modification repertoire has yet to be comprehensively mapped. N-myristoylation (MYR) is a crucial eukaryotic N-terminal protein modification. Here we mapped complete Homo sapiens and Arabidopsis thaliana myristoylomes. The crystal structures of human modifier NMT1 complexed with reactive and nonreactive target-mimicking peptide ligands revealed unexpected binding clefts and a modifier recognition pattern. This information allowed integrated mapping of myristoylomes using peptide macroarrays, dedicated prediction algorithms, and in vivo mass spectrometry. Global MYR profiling at the genomic scale identified over a thousand novel, heterogeneous targets in both organisms. Surprisingly, MYR involved a non-negligible set of overlapping targets with N-acetylation, and the sequence signature marks for a third proximal acylation—S-palmitoylation—were genomically imprinted, allowing recognition of sequences exhibiting both acylations. Together, the data extend the N-end rule concept for Gly-starting proteins to subcellular compartmentalization and reveal the main neighbors influencing protein modification profiles and consequent cell fate.
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Fig. 1: The NMT recognition site is characterized by four distinct pockets, a bottleneck, and an outer salt bridge.
Fig. 2: MS MYR diagnoses.
Fig. 3: Impact and imprinting of S-palmitoylation at the genomic scale.
Fig. 4: Modification pattern of proteins starting with glycine.
Fig. 5: Sequential action of the various enzymes involved in N-terminal maturation of Met-Gly-starting polypeptide chains.
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This work was funded by Agence Nationale de la Recherche (ANR-2010-BLAN-1611-01) and Fondation ARC (SFI2011120111203841). The team benefits from the support of the LabEx Saclay Plant Sciences-SPS (ANR-10-LABX-0040-SPS). C.D., B.C., and S.C. were supported by postdoctoral fellowships (CNRS). We thank W. Majeran and C. Micalella for initial help with sample preparation and in vitro assays and all members of the group for stimulating discussions. The 2016 innovative experimental training Master class students hosted in the Gif laboratory actively contributed to early crystallographic attempts of one NMT complex. C. Duyckaerts (APHP) and Hopital Pitié Salpêtrière (Université Pierre et Marie Curie, Paris) kindly allowed access to human tissue samples from Neuro-CEB (http://www.neuroceb.org/) and M.-A. Loriot and A. Al Ali to sample preparation. J. Bignon (CNRS, Gif) allowed access to human cell culture facility. This work used the facilities and expertise of the SICaPS mass spectrometry platform at I2BC (Gif). We thank ESRF staff for help with data collection.
Coralie L. Ebert
Present address: The Weizmann Institute, Rehovot, Israel
These authors contributed equally: Benoit Castrec, Cyril Dian.
Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris Saclay, Gif-sur-Yvette cedex, France
Benoit Castrec
, Cyril Dian
, Sarah Ciccone
, Coralie L. Ebert
, Willy V. Bienvenut
, Carmela Giglione
& Thierry Meinnel
Institut de Chimie des Substances Naturelles, CNRS Univ. Paris-Sud, Université Paris Saclay, Gif-sur-Yvette cedex, France
Jean-Pierre Le Caer
Laboratoire d'Informatique, École Polytechnique, Palaiseau, France
Jean-Marc Steyaert
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C.D. performed NMT cloning, purification, and structural analysis. B.C. and S.C. performed in vitro assays. W.V.B. and J.P.L.C performed mass spectrometry measurements and analysis. C.L.E. and J.-M.S. built the SVM classifiers. C.G. and T.M. designed the research, supervised the overall project, analyzed the data, and wrote the manuscript.
Correspondence to Carmela Giglione or Thierry Meinnel.
The authors declare no competing interests.
Publisher's note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary Text and Figures
Supplementary Tables 1–3, Supplementary Figures 1–5
Reporting Summary
Supplementary Dataset 1
Data associated with the 2k macroarray and the Arabidopsis thaliana myristoylome
Complete human myristoylome
Protein N-Gly termini isolated from humans
Protein N-Gly termini from Arabidopsis thaliana
Castrec, B., Dian, C., Ciccone, S. et al. Structural and genomic decoding of human and plant myristoylomes reveals a definitive recognition pattern. Nat Chem Biol 14, 671–679 (2018) doi:10.1038/s41589-018-0077-5
Received: 29 September 2017
Issue Date: July 2018
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Samuel S. H. Weng
, Fatih Demir
, Enes K. Ergin
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, Anuli Uzozie
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, Janice Tsui
, Pitter F. Huesgen
& Philipp F. Lange
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Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases
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, Michael Howell
, Dinis P. Calado
& Edward W. Tate
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Andrea Goya Grocin
, Remigiusz A. Serwa
, Julia Morales Sanfrutos
, Markus Ritzefeld
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Q: ImportError: No module named comments django I'm using os x , I tried to run the project that I installed from Github
https://github.com/cfpb/idea-box
but there is error says : ImportError: No module named comments
maybe I miss something but since I'm newbie in Django I can't figure it out

A: Django comments are deprecated in latest version. You can either install older django version (such as 1.5).
Or the better solution is to install comments from external repository like so:
pip install django-contrib-comments

and then change all imports like this:
from django.contrib.comments.models import Comment # old
from django_comments.models import Comment # new

Sources:
Django's docs
Another question

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text:
package com.facebook.buck.cxx;

import com.facebook.buck.core.model.BuildTarget;
import com.facebook.buck.core.rules.ActionGraphBuilder;
import com.facebook.buck.core.rules.BuildRule;
import com.facebook.buck.core.rules.impl.SymlinkTree;
import com.facebook.buck.core.sourcepath.SourcePath;
import com.facebook.buck.cxx.toolchain.CxxPlatform;
import com.facebook.buck.cxx.toolchain.HeaderMode;
import com.facebook.buck.cxx.toolchain.HeaderSymlinkTree;
import com.facebook.buck.cxx.toolchain.HeaderSymlinkTreeWithModuleMap;
import com.facebook.buck.cxx.toolchain.HeaderVisibility;
import com.facebook.buck.cxx.toolchain.Preprocessor;
import com.facebook.buck.io.filesystem.ProjectFilesystem;
import com.facebook.buck.rules.args.StringArg;
import com.facebook.buck.rules.coercer.FrameworkPath;
import com.google.common.base.Preconditions;
import com.google.common.collect.FluentIterable;
import com.google.common.collect.ImmutableList;
import com.google.common.collect.ImmutableListMultimap;
import com.google.common.collect.ImmutableMap;
import com.google.common.collect.Multimap;
import com.google.common.collect.Multimaps;
import java.nio.file.Path;
import java.util.Collection;
import java.util.LinkedHashMap;
import java.util.Map;
import java.util.Optional;

public class CxxPreprocessables {

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    builder.addIncludes(CxxSymlinkTreeHeaders.from(symlinkTree, includeType));
    return builder;
  }

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      BuildTarget buildTarget,
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                Multimaps.transformValues(exportedPreprocessorFlags, StringArg::of)))
        .addAllFrameworks(frameworks)
        .build();
  }
}

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It's hard to argue with Mother's Day brunch. It's tradition, and hey, it's brunch. But if you're interested in mixing up things a bit this year, we've got just the ticket. Well, four tickets—all disguised as themed brunch menus.
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The full scope of damages that are available in any accident are available in premises liability lawsuits as well. The only way we measure damages in our civil society is by payment of money, generally speaking, on injury cases. Potentially, the damages are available through insurance. Just like automobile insurance, there's homeowner's insurance, business insurance, and premises liability insurance. The damages are what happened to the individual as a result of the other party's actions or failure to act as a reasonable property owner. Those damages are available to the person who is injured.
What Are The Top Misconceptions People Have About Premises Liability Claims?
The most common misconception occurs when somebody believes they can't sue because it happened on their family's property or at a friend's house. They feel like nothing can be done or are too willing to accept full responsibility when someone else is actually responsible for their injury. They feel guilty and yet they are suffering greatly due to another person's negligence. They may also believe that they can always recover if an injury happens on another person's property. This can be a very complex area of the law and liability must still be proven. For example, at a grocery store, the injured party must prove that the store knew or failed to exercise reasonable diligence to know about the danger that caused the injury. In public parks and recreation areas, there are also exceptions to liability. Please see your attorney for evaluation of the merits of your case.
For more information on Premises Liability Claims In California, a personal case evaluation is your next best step. Get the information and legal answers you are seeking by calling (714) 689-2660 today.
What Factors Determine The Viability Of A Personal Injury Claim?
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Williams Baptist University has set a revised date for its 2020 commencement exercises. The graduation ceremony is now scheduled for August 8 at 10 a.m. on the Williams campus.
WBU had originally planned to hold commencement on May 2, but the ceremony had to be postponed due to the COVID-19 pandemic.
"These graduates have come to be a treasured part of our university family, and we want to celebrate this tremendous achievement in their lives," said Dr. Stan Norman, WBU president. "It grieved us to postpone our commencement, but now we are very excited to announce a date for the graduation ceremony to take place."
The president noted that WBU continues to monitor guidance from the state of Arkansas on the pandemic, and those recommendations are helping the university shape plans for the graduation ceremony.
"As August 8 draws closer, we will announce more detailed plans for a ceremony to recognize and celebrate our graduates, while also giving full consideration to the wellbeing of all involved," he said.
Approximately 80 graduates are expected to be a part of the WBU class of 2020. Although commencement is set for August, Williams will update the transcripts and status of this year's graduates as soon as they complete their studies.
PreviousPrevious post:Gibbens & Rhoads Awarded Professor Emeritus StatusNextNext post:WBU Announces 2020 Academic Awards


Wednesday March 19th, Stories from the Ceredigion Lead Mines, with Alison Lochhead, Gareth Hoskins, Andy Cairns, Dylan Cairns Howarth and Planet Magazine, Gas Gallery, Aberystwyth.
Saturday May 10th, The Llwynwermwnt Changeling, at the Gas Gallery, Aberystwyth, with Ceri and Elsa.
Sunday June 1st, The Toad, the Witch and the Bog Bodies, a Storywalk on Borth Bog, 2pm, with stories from Justin the warden of Ynys Las and music from Ceri and Elsa.
Wednesday June 4th, Noson Lawen at the Gas Gallery, Aberystwyth, with Ceri and Elsa, and the Grassie Busville Band, 8pm.
Saturday June 7th, Ceredigion Folk Tales at Peaceful Places, Llandre Church, 2pm and all afternoon.
Sunday June 22nd Workshops on visual storytelling, book illustration, folk song and music, at Llanllwchaearn Church Hall, New Quay, 2 till 5, free courtesy of NIACE, with Ceri and Elsa.
July 4-6th The Crow and the Canary, at Beyond the Borders International Storytelling Festival, with Ceri and Elsa. Also a talk and workshops on Visual Storytelling.
Wednesday July 16th Myra's Fairy Tales at Dylan Thomas Food Festival, Cardigan.
Saturday July 26th, Sigl-di-gwt at Parc Cwm Darran, Caerphilly, Workshops at 2pm, Show at 3pm, with Ceri and Elsa.
Monday July 28th The Toad and the Witch, a Storywalk on Borth Bog, 1.30pm, with stories from Justin the warden of Ynys Las and music from Ceri and Elsa.
Wednesday July 30th, Myra's Fairy Tales, for the Music Fest, Aberystwyth Arts Centre Foyes, 7.15pm, with Ceri and Elsa.
Saturday August 2nd, Private Event.
Monday August 25th, Sigl-di-gwt at the Queens, New Quay, with 4 courses of Rose's delicious home cooking. Contact the Queens to book a table.
Wednesday Oct 29th, Book launch at Waterstones, Aberystwyth, Arthur and Me by Sarah Todd Taylor.
Friday Oct 31st, Oxfam Storytelling afternoon to raise funds for the Sudanese emergency appeal, 2.00pm onwards. Oxfam Music and Bookshop, North Parade, Aberystwyth.
Saturday 15th Nov, scary tales on the Horror Express for Abertoir Festival on the Vale of Rheidol Railway, 7pm, book through the Arts Centre.
Wednesday 19th Nov. Ceredigion Folk Tales and folk music, Ystwyth Books, Aberystwyth, with Elsa and Ceri, and Chris Grooms, 7pm.
Friday 21st Nov, Myra's Fairy Tales at Ystrad Meurig, with Elsa and Ceri, 7.30pm.
Friday 28th Nov, Stories of maps and routes of the Cambrian Mountains, as part of the Maps and Makers exhibition, with Alison Lochhead, at the Gas Gallery, Aberystwyth 7.30pm.
Saturday 29th Nov, Ceredigion Folk Tales, Neuadd Lisburne Llanafan, 7pm.
Sunday 30th Nov, Ambling Around Aber, with Jez Danks and Jane Lloyd Francis, as part of the Maps and Makers exhibition at the Gas Gallery. Two walks t 11am and 2pm, meet at the Gallery.
January 10th, 2015, onwards. A Cabinet of Curiosities, Exhibition of artwork from the Shows, Gas Gallery, Aberystwyth.
January 14th, Cabinet of Curiosities Exhibition, with a full show by Elsa Davies and Ceri Owen-Jones, and the films of Jake Whittaker.
Sunday February 22nd, Tales of Thomas Phillips, Carmarthen Station Master, told on the old railway line between Pencader and Carmamrthen, for Singing the Line, all afternoon.
Friday February 27th, Workshops and fairytales at Kingston Art College, 1pm all afternoon.
Tuesday March 31st, Myra Evans' fairytales at Swansea Storytelling Club, with Elsa and Ceri.
Friday April 10th, The Crow and the Canary, Siop Cynfelyn, Tre'r Ddol, 7.30pm, with Elsa and Ceri.
May 31st, Tan yn y Mynydd/Fire in the Mountain, near Cnwch Coch, 9pm, with Ailsa and Pixy Tom and a Cabinet of Curiosities.
Thursday July 16th, Story walk on Cors Fochno/Borth Bog Cors Fochno, with Elsa, Ceri and Justin.
Thursday July 23rd, Myra Evans' Fairytales at Llanfair Clydogau , with Elsa and Ceri, 8pm.
Saturday August 1, Welsh stories at Celtfest, Y Cwps, Aberystwyth, 8pm, with an array of traditional musicians and poets.
Sept 19th, Stories at the Hans Christian Andersen Statue, Central Park, New York.
Sept 26, The Crow and the Canary, a Salon at the Center for Engaged Storytelling, New York.
Nov 6, The Crow and the Canary, at Tenby Storytelling Club, Cafe Vista, 8pm, with Elsa and Ceri.
Sunday 27th March, A Cabinet of Curiosities, Halsway Manor, Somerset, 2pm.
Saturday 6th July, Sigl-di-gwt, Towyn Chapel, New Quay, 6pm, followed by Corelw.
Fri/Sat/Sun 20/21/22 Dec, Wild West Welsh Tales on the Vale of Rheidol Railway, with mince pies, mulled wine and and a trip on the train to the frozen North (Capel Bangor) to meet St Nick.
Thursday 17th Oct, Wild Welsh Tales, Cary, North Carolina.
Feb 28 Myra's Fairytales, Bedwellty House, Tredegar, St David's Day Celebration, 3pm, with Elsa and Ceri.
July 1-3, Beyond the Border Storytelling Festival, St Donats.
July 25, Flora, story of John Henry Salter the man who wrote the Ceredigion Flora, with Ailsa Mair Hughes, in the Flora exhibition at Aberystwyth Ars Centre, 1pm, free event for Aber Music Fest.
Oct 1, West Virginia Storytelling Guild, WVU, Morgantown WV.
Oct 18 Blodeugerdd, the Flora of Ceredigion with Ailsa Mair Hughes, at Medina, Park St, Aberystwyth, 6pm for food, 27pm for storries.
Oct 31 Spooky stories for Halloween, at Pwcashop, the Arcade, Cardigan, c 6pm.
Nov 17, Ghost stories on Constitution Hill, Aberystwyth, as part of Abertoir.
Join Elsa Davies and Ceri Owen-Jones (Deuair), Hannah Engelkamp (Seaside Donkey), Peter Stevenson (storiwr), for a whole day's drive around the Dyfi Biosphere with some very special guest musicians and tale-tellers, a host of local folk tales told in their landscape, music and songs from the area, informal chat and good conversation.
Ends c 4pm. Beware of toads.
10 March, Crossing the Boundary, with Ailsa Mair Hughes, at Aberystwyth Storytelling Festival, 6.45pm. There will also be a showing of The Talking Tree.
July 6 The Lost Fairy Tales and Folk Songs of west Wales, with Elsa and Ceri, British Psychology Conference, Aber University 8.30pm.
Neidwch ar y Bws Straeon I glywed straeon a thonau o Fynydd Bach, Ceinewydd, a'r Hafod a dewch i gyfarfod a Morwyn Llyn Eiddwen, Gwrach Pennant, straeon tylwyth teg Myra Evans, Coeden sy'n Siarad yng Nghwmystwyth, a Lady-boys Trefenter.
A chance to explore Peter Stevenson's extensive and diverse personal collection of instruments.
29 July WELSH FOLK TALES, STORY MAPS, AND CHILDREN'S BOOK ILLUSTRATION.
Chwedlau Gwerin Cymru, Stori-fapiau, a Darlunio Llyfrau Plant. gyda Valériane Leblond a Peter Stevenson. Contes populaires gallois, Cartes à histoires et Illustration de livres d'images.
Do we own the land or does the land own us?
2 Feb Dathlu Cymuned / Celebrating Community, Stories from Cymerau Project, at Llanfach Hall, Tre Taliesin, with Gwilym Morus, 2pm - 3.
25 Oct Borth Senior Citizens, Leisure Centre, Borth, 2pm.
27/ 28 Oct Gwyl Tan a Mor Harlech Fire and Sea Festival. Saturday; Crankie making session at 10am till 4pm, storytelling at 4pm. Sunday; Book illustration session at 10am.
30 Oct Amgueddfa Ceredigion Museum, Illustration workshop 2-4 pm.


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Klas Eriksson med olika stavningsvarianter kan syfta på:

 Claes Eriksson (född 1950), svensk skådespelare och regissör, medlem i humorgruppen Galenskaparna & After Shave
 Claes Eriksson (fotbollstränare) (född 1958), svensk fotbollstränare
 Claes Ericson (född 1977), svensk författare och förläggare
 Clas Eriksson (född 1973), svensk ishockeyspelare och -tränare
 Klas Eriksson (skådespelare) (född 1985), svensk skådespelare och komiker

Se även
 Nicolaus Erici

redpajama_set_name: RedPajamaWikipedia


Halloween ghost holding a smiling pumpkin. Cut from 1/8" luan birch wood. Make a magnet or ornament.
to print from your computer.
Transfer the outline onto the cutout AFTER the base coat has been painted. For example- if the ghost is white, paint it white first, then tranfer the pattern onto the painted surface.
Here is a delightful Halloween sign you can make from wood. Click on the pattern and transfer onto pine wood. For best results, paint the base of this Halloween pattern, let dry - then using graphite paper, transfer the design onto the wood (on top of the painted base coat).
Suggested colors for the cat and pumpkins: paint the cat black. Base coat paint the pumpkins orange. Transfer the design on the dried base coat. Then fill in with details. Hint- you can use a Sharpie brand marker for the face if desired.
It's Halloween craft cat outline. Dracula Halloween outline.
1) Use this on a Halloween cake: Print out this picture of Dracula onto card stock. By having the paper a bit thick, take an exact o knife and cut out the face. Sprinkle powdered sugar through the holes of the stencil onto the top of a chocolate cake. Or you could also paste white or yellow frosting through the holes as well.
2) Perfect for displaying in windows. Using black card stock, transfer the face onto the stock. Cut out the eyes, nose and mouth. Place in a back lite window.


Tulsa, Oklahoma sits at a confluence of Southern, Midwestern, and Southwestern (Native American) regions of the USA. I was born there, white, male, protestant, and evangelical. I got the idea that my parents, who had brought two children each into a yours-mine-and-ours weren't entirely sure what to do with me.
The beginning of the end of my complaining about being raised into bourgeois fundamentalism came in my early 30s when a wise friend said, "I'm grateful for my fundamentalist upbringing. It was always, 'The Bible says...the Bible says...' In making me constantly appeal to the authority of text they made a scholar out of me. In making me sing about it they made a musician out of me. I wouldn't be who am without that." I recite that story to myself sometimes.
An integrated magnet school, professors who were more interested in teaching me to think than training me for a job or a social class, a strong and engaging partner, living abroad in a very different culture, learning to connect everything to everything, helping young people do the same, traveling, becoming a parent, relinquishing my youth—these have all engendered personal development and expansion of consciousness.
I am at an age where for the first time I feel that I have, in the words of Archimedes, "a lever and a place to stand." No telling how long I have, and there are surely struggles to come, but I have the sense of an overall trajectory for my life. How fortunate is that?


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Q: One-way independent ANOVA where I expect two levels to be very similar and the other to be different. What's the right test? I'm expecting Groups 1 & 2 to be very similar and Group 3 to be different.
I'm using a very large data set and feel that power won't be an issue. Initially I felt that I'd then be expecting a significant ANOVA, and then in planned comparisons I'd expect 1 vs 2 to be non-significant while 1 vs 3 and 2 vs 3 should be significant. While that is actually how my data turned out I'm now thinking this was the wrong way to go about things.
When comparing 1 vs 2 should I have used equivalence testing (e.g. http://www.cscu.cornell.edu/news/statnews/stnews85.pdf) instead? If so, how could I have gone about that using SPSS or some other commonly available software?


Single. Pull. I recall it; I recall all of it. The thought of reclaiming it, of touching it , in the company of the others, appeals to me on a level of need I am ashamed to confess to. It was the neighborhood which made those experiences meaningful, however. I really could never recreate those salad days; even though by some dark miracle all my older friends and guildies from 2006 were to wow classic gold rematerialize in Classic, we'd be different people.This is an issue for an expensive undertaking marketed (as so many other things are nowadays ) with appeals to nostalgia. It creates a quandary: how can you create and maintain a community of gamers who are there to find the 1 thing you cannot give themno matter how hard you try? The nostalgia is premised on a lot more than code, a lot more than even the rolled-back landscape of Azeroth to its pre-Cataclysm impurity; it's premised on the bonds we forged within that world. A world we could never, truly, go back to.I'd love nothing more than to recapture those days; I know it's impossible since they're tangled in a net of context that no server could host. Who I was, where I was, simply can not be encoded to World of Warcraft: Classic. I will come to Azeroth that is old as a traveler, not able to return. It may even offer you a novelty into the legions who combined World of Warcraft after its later expansions fused themselves to the game. Yet it is hard to imagine most of the players staying within an Azeroth shorn of the quality-of-life improvements that ensured WoW's victory was long-lived. All Of World of Warcraft Products Sale at https://www.mmogo.com/Wow-classic/Gold.html. 100% Secure, Fast and Guaranteed!


text:
package org.docksidestage.oracle.dbflute.exentity;

import org.docksidestage.oracle.dbflute.bsentity.BsWhiteTarget;

/**
 * The entity of WHITE_TARGET.
 * <p>
 * You can implement your original methods here.
 * This class remains when re-generating.
 * </p>
 * @author oracleman
 */
public class WhiteTarget extends BsWhiteTarget {

    /** Serial version UID. (Default) */
    private static final long serialVersionUID = 1L;
}


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Programs + Initiatives
Economy + Society
Effective Philanthropy
Gender Equity + Governance
U.S. Democracy
New transportation strategy addresses climate change, health and the economy
Explore Our Grantmaking
Search Year Year 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000
Search Program Program Economy and Society Education Performing Arts Environment Effective Philanthropy Gender Equity and Governance SF Bay Area Cyber Special Projects U.S. Democracy
Ideas + Practice
Gender Equity and Governance
East Oakland Youth Development Center
For General Operating Support
Date Awarded
General Support/Organization
About the Grantee
Grantee Website
www.eoydc.org/
8200 International Boulevard
Grants to this Grantee
for organizational adaptation
The East Oakland Youth Development Center (EOYDC) is dedicated to developing the social and leadership capacities of young people between five and 24 years of age, so they can be more successful in educational settings, jobs, and community service. Each week, EOYDC offers a wide variety of academic, athletic, and arts and culture programming, after school and during the summer, to 300 students attending East Oakland public schools. The organization often has long relationships, averaging seven years, with the youth it serves. This grant will support EOYDC's organizational adaptation planning and implementation, and advance the Performing Arts Program's Youth strategy.
All Grants to this Grantee
As part of the PropelNext partnership with the Edna McConnell Clark Foundation, we are recommending grants to seven organizations in the Bay Area working with high-risk youth: Alternatives in Action, Beyond Emancipation, Community Youth Center of San Francisco, East Oakland Youth Development Center, Huckleberry Youth Programs, Lavender Youth Recreation and Information Center, and Social Advocates for Youth. We selected these organizations from a pool of forty-eight candidates, after a thorough due diligence process involving external reviewers. Of the seven recommended organizations, three are based in San Francisco, three in Oakland, and one in Sonoma County. These organizations help youth ages nine to twenty-four who are at risk of dropping out of school, involved in the juvenile justice system, runaway, homeless, foster youth, or suffering from domestic violence. The organizations help in a variety of ways, providing mentors, after-school programming, job training, tutoring, shelter, community service projects, and leadership opportunities. These seven organizations will participate in the PropelNext program over the next three years. Another eight organizations will also be participating in the PropelNext cohort, including two others in the Bay Area, funded by the Packard and Sobrato foundations, and six organizations in Southern California, funded by the Weingart Foundation. In addition to the grant funds, the PropelNext program will provide training, individual coaching, technical assistance, and peer learning sessions to help the organizations develop their theories of change and implement performance measurement systems. We hope this initiative will significantly strengthen these youth-serving organizations, build a more enduring performance-based culture in the nonprofit sector, and ultimately lead to better outcomes for Bay Area youth.
From data revolutionary to data governance advocate and back again: Three lessons from the journey
Jonathan Pershing Joins Hewlett Foundation as Environment Program Director
Hewlett 50 Arts Commissions FAQ
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© 2022 William and Flora Hewlett Foundation


FC Red Bull Salzburg is an Austrian association football club, based in Wals-Siezenheim. Their home ground is the Red Bull Arena. Due to sponsorship limits, the club is known as FC Salzburg and wears a modified crest when playing in UEFA competitions. Founded in 1933, the club has won its first Austrian Bundesliga in 1994, which was the first of three in the space of four seasons which also saw them reach the 1994 UEFA Cup Final. The team currently has seven league titles to its name. Buy FC Red Bull Salzburg tickets online now!!
Feel free to browse the FC Red Bull Salzburg fixtures. We have FC Red Bull Salzburg football tickets available for home and away FC Red Bull Salzburg matches in Europe such as Champions League tickets and Europa League Final tickets.
Buy FC Red Bull Salzburg tickets online for the UEFA Europa League (UEFA Cup) through our safe and secure booking system. All FC Red Bull Salzburg ticket orders are guaranteed and dispatched by our reliable partners FedEx and Royal Mail Special Delivery. We are not affiliated with the FC Red Bull Salzburg football club or FC Salzburg stadium and tickets may be priced above face value.


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Doctors' body in Canada backs down on policy to rescind conscience rights
Podcast – WDBO – 9-24-08
Top Public Health Official Urges Conscience Protections
The National Post is reporting that the regulating body for Ontario physicians has backed off a controversial proposal that would have forced doctors to put aside their religious views when dealing with patients. Protests from the Ontario Medical Association and numerous religious groups appear to have tempered the thinking of the College of Physicians and Surgeons of Ontario. Hopefully the US will do the same.
The new document, released on Wednesday, has removed provisions that would have potentially seen doctors face more misconduct charges for putting their own conscience before the convenience of patients.
For example, it could have applied to doctors who not only refuse to prescribe birth control pills, or do fertility treatments for same-sex couples, but also to those who refuse to offer referrals to doctors who do those things.
"Referring is just a way of sloughing off your responsibility," Rabbi Reuven Bulka of Congregation Machzikei Hadas in Ottawa, said last week. "If you're opposed to these things, referring is the same as taking part in the evil."
The College of Physicians and Surgeons released its first draft policy in August. It warned doctors that they could see more charges being filed through the Ontario Human Rights Commission for withholding services. But it also indicated that doctors would face misconduct charges by the college as well, something that happens in no other province.
The new policy, which is scheduled to be voted on today, now serves as more of a warning about what doctors may face from the Human Rights Commission.
"The draft policy was always meant as a basis for discussion," said Jill Hefley, a spokeswoman for the college.
Last week, the Ontario Medical Association asked the college to abandon the draft policy because it "interfered with physicians' existing rights and freedoms." It said the draft failed to note that doctors are also protected under the Charter of Rights and Freedoms, like any other citizen.
"We believe it should never be professional misconduct for an Ontarian physician to act in accordance with his or her religious beliefs."
Thomas Collins, Archbishop of the Dioceses of Toronto, also told the college that many physicians feared they would be "brought before human rights tribunals for following their consciences." But he saw no reason why it would then be necessary for the college to add sanctions of its own. "Is that the cost of being true to one's conscience?" he asked.
Sean Murphy of the Protection of Conscience Project, a group that tries to protect the rights of health workers, said the new document appears to be much improved from the original draft.
"It's more clear in this document that the bogey man is the Ontario Human Rights Commission," he said.
But he is concerned that one clause remaining in the policy could hurt doctors who exercise conscience.
It says the "college has its own expectations for physicians who limit their practice, refuse to accept individuals as patients, or end a physician-patient relationship on the basis of moral beliefs."
He said this provision still needs to be clarified by officials.
Dr. Walt's "The Magic of Family Medicine" Touched Hearts at the "The Art of Medicine Rounds" in Alabama
My Newest Television Feature Launched Last Week
What's the Truth about Ivermectin for COVID?


Long Lake Living: Is Your Septic System Contaminating Long Lake?
Is Your Septic System Contaminating Long Lake?
Let's be vigilant in maintaining our septic systems so that they don't contaminate surrounding areas.
U of M Figure 1: Typical cross section of a septic tank showing the layers of sludge, liquid, and scum. Newer tanks will have access ports for pumping. Older tanks may have a manhole cover that should be removed for pumping. Inspection ports on older tanks are not suitable for pumping.
Official Ice Out was on April 6, 2016!


Energetic Objective - Gary Mitchell Penned with information from Brian Rodriguez, Patrick Adams, Kevin Lewis, John Green, Mark Thomas, Kevin Davis, Justin Garcia, Edward Johnson, Samuel Anderson, Andrew Brown, Daniel Miller, Nicholas Perez, William Scott, Mark Edwards, Larry Hill, Kenneth Walker, Jonathan Rodriguez, Raymond Hernandez, Paul Thomas, Stephen Evans.
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Jimmy Garoppolo has telling response to question about 49ers QB situation
In spite of all the persistent speculation about Trey Lance potentially taking his job, San Francisco 49ers quarterback Jimmy Garoppolo seems very much at ease with the situation.
In light of coach Kyle Shanahan's comments about having a pretty good idea of who the team's starter would be in Week 1, Garoppolo was asked Wednesday if he had any idea. Garoppolo's response was simple, but it said everything one would need to know.
"Hell yeah, I have a pretty good idea," Garoppolo said with a telling grin.
#49ers Jimmy Garoppolo says he has a pretty good idea who will be the starting quarterback week 1 pic.twitter.com/rGZOqZX5pZ
— Alex Tran (@nineralex) August 25, 2021
While there's been the occasional comment about Lance gaining ground on Garoppolo, the Niners have been very consistent in saying that the starting job remains Garoppolo's. Even though Lance has impressed, it certainly doesn't seem that Shanahan is about to change his mind on that.
Garoppolo does have work to do to re-establish himself as a high-end NFL quarterback. Injuries limited him to just six games in 2020, and he threw an underwhelming seven touchdowns to go with five interceptions.


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Wez G - Shuffle
Wez G from Shuffle is a house music DJ . Since 1995 Shuffle have brought underground dance music from South Wales to the world. Wesley is also a Liverpool fan and enjoys travel and culture, especially foreign languages.
Cambodia and the Khmer Rouge - Beauty and the Beast?
Last week the trial began of Comrade Duch, one of five former Khmer Rouge senior personnel to go before a special UN-led war crimes tribunal, investigating the atrocities that were committed in Cambodia during the 1970s. I have studied Cambodia in depth and find it a very interesting subject so I thought it opportune to include an article in the blog.
The ancient Angkor kingdom prospered much during the Middle Ages and leaves us remnants today of a magnificent Khmer civilization which was highly advanced and produced some of the greatest architecture ever known to our planet. The highlight of this culture can be seen in the magnificence of Angkor Wat which is one of the most architecturally precise monuments of all time and lies locked away in the Cambodian jungle.
During the 1970s, when the US was fighting the North Vietnamese, neighbouring Cambodia became involved in the conflict. As a result of Cambodian government policies at the time, the US were carpet bombing much of the country. The King of Cambodia, Norodom Sihanouk, sided with the political opposition in an attempt to save his country from peril. With massive rural support the Khmer Rouge army, led by Pol Pot, entered the Cambodian capital Phnom Penh on 17th April 1975, and seized control of the state. What followed in Cambodia is one of the most startling incidents in human history and resulted in the deaths of approximately 2 million people out of a population of 7.3 million.
The Khmer Rouge were communists and had developed their political theories through the study of marxism in foreign universities. Most of the Khmer Rouge leadership had in fact studied in Paris, the capital of the former colonial masters of French IndoChina. Pol Pot, however, the regime's leader had remained in Cambodia where he had built up his armed forces to a position whereby they were able to seize power. The Khmer Rouge had developed a version of Marxism loosely based on that of Chairman Mao, who had successfully swept his Red Army into power in China in very recent memory. The Khmer Rouge declared Cambodia as the People's Republic of Kampuchea and set about instantly imposing their political ideals.
Under the guise of protecting the people from the ongoing carpet bombing by the Americans, the Khmer Rouge forcibly removed the entire population of Phnom Penh, and indeed the other major cities, into the countryside. Khmer communism was a warped brand of the Marxist philosophy. in Kampuchea there was to be no steady shift of class revolutions. Pol Pot envisaged an instant turn to full communism and in the vein of Mao before him set about devising an agrarian revolution akin to China's Great Leap Forward. The parasitic city dwellers would join their rural compatriots as peasants and through forced labour, the entire population would put its hand to tilling the soil. Kampuchea would become self-dependent and effectively the Khmer Rouge leadership sealed the borders, shut their country off from the rest of the world and proceeded with one of the most radical social experiments in history.
Dissenters and potential opponents of the new authorities were quickly and systematically removed. The first elements of society to feel the terror of Khmer Rouge 'smashing to bits' were the doctors and lawyers and other professional classes who were the first to fill the mass grave sites that would become a lasting legacy of Pol Pot's régime. The army would be the backbone of Khmer Rouge power and would brutalise the population in ways beyond belief.
The political theory held that strong force would initially be necessary to enforce the goals of the revolution. The land was quickly collectivised and people were set to work in communes, under the auspices of committees who would liase with the government forces. Traditions were abandonned, religion was abolished. New education measures meant that history began again at day 1. Everyone was to be reeducated with the new doctrines. Dissent was intolerable and amid the severe torture that was used there was widespread killing. Where the bullets of Khmer Rouge soldiers failed to penetrate, starvation through famine due to a failure of the agricultural policy, in particular the failure of adequate food distribution, ensued. An army of child soldiers arose, who were completely brainwashed with the ideology of the new régime and who were trained to inform on their own families and were conditioned to provide the brutal backbone of the Khmer Rouge system of terror.
Pure marxist theory excludes the position of supreme leader. In a communist society all are supposed to be equal. However, Pol Pot was a pure dictator. He applied the purges of the people to his own party. Although the army and government were clearly a priveleged class, they were not free from the terror perpetuated by the new system. In the abandonned Phnom Penh an interrogation centre and prison for internal dissidents was established. Tuol Sleng or S-21 was assigned to the command of Comrade Duch. He was provided with the full range of torture istruments with which to extract confessions from any suspected clients so that they could then be legitimately executed for their crimes against the state. It is estimated that Duch was individually responsible for the deaths of 14000 Tuol Sleng prisoners. A British journalist, Nic Dunlop, went out to Cambodia in the late nineties on a mission to find Duch and to investigate the inner workings of S-21. He managed to discover Duch, a new Christian convert, living on a false identity and working as a teacher in rural Cambodia. This discovery led to the great book that Dunlop wrote, 'The Lost Executioner' (see below) and also meant that Duch's cover was blown. He was handed over to the authorities to await a proper trial for his actions. That trial has now begun.
Not all under the Khmer Rouge was bad. Although famine was initially a problem, productivity in the collective farms did increase and certain factories in the cities were re-opened. In moves reminiscent of the Angkor empire, vast irrigation projects were undergone in an attempt to improve agricultural productivity. Cash was eliminated and a pure barter economy existed, with rice being the principal form of currency. Cambodia had achieved a certain independence from the imperial forces that had traditionally dominated the region. This was an aim of the régime and apart from the good relations it maintained with the People's Republic of China, Cambodia was purely independent. Little was known of what was actually occurring within the borders due to its pariah status.
Ethnic populations did suffer incredibly, in particular the Vietnamese minorities. Thais in the border regions, Muslims, Christians and Buddhist monks were also prone to experiencing the full force of the authorities' brutality. With the control of the native populations achieved, Pol Pot began to seek out futher Khmer Rouge goals. He dreamed of a wider state, a means of incorporating the Mekong delta, an expansive empire akin to the great Angkor one his predecessors had carved out in the jungles of southeast Asia.
Eventually, the urge for war became too much. Constantly readying the army and practising manouvres in constant border skirmishes eventually proved too much temptation to resist a full scale war with the hated Vietnamese neighbour. Pol Pot relied heavily on his Chinese ally aiding a Khmer Rouge assault on Soviet-supported Vietnam. Preceeded by an increasing dispatch of distraught Cambodian refugees to aid camps set up in border areas, eventually a full scale war with Vietnam saw the brutal terror of the Khmer Rouge brought to a close. In January 1979 Phnom Penh was liberated by the Vietnamese army and Cambodia became a subsidiary state of Vietnam for the next decade. Pol Pot and the remnants of the Khmer Rouge sought refuge on the borders of Thailand where they managed to maintain Khmer Rouge control until the late nineties when in 1998 Pol Pot died.
The international community began to writhe in guilt after the true scale of the Cambodian horrors emerged. The world was a silent witness to some of the harshest breaches of human rights that man's warped mind has ever produced. Pol Pot dies without ever standing trial for his actions. Some of the perpetuators now face justice. in the dock alongside Comrade Duch, stand Nuon Chea, Ieng Sary, Ieng Thirith and Khieu Samphan. Having read the book about Duch, I feel a certain sympathy for him. As he has clearly stated at his trial, he was merely following the orders of his superiors. He had no real choice about his actions as he would have simply been 'smashed to bits' himself. However, in light of the terror he must have committed, his very humanity must be called into question.
The Khmer Rouge make an interesting tale as it is a tale of extremes. We focus now on the brutality of the régime and seek evidence of the full scale of horrors that emerged during the existence of the Democratic Republic of Kampuchea. It is easy to condemn the movement. However, in studying it, I can see a mirror image, an image of beauty. We take our lives and our modern societies for granted. The leaders of the Khmer Rouge were empassioned by a vision which does not run parallel to that of common international ideas. They wanted to reject the status quo entirely, to create a better future for their country. They set about abandonning modernity for perhaps a neolithic alternative. I think that in some ways by putting the people back on the land they were very right. Are people in cities parasites? In the countryside man becomes closer to nature. In the modern world we are so far removed from nature that we have forgotten what it actually is. Perhaps the global problems of climate change would evaporate if there was a worldwide movement back to our rural hinterlands? The Khmer Rouge at the very least had the conviction to put their theories into practise. All revolutions experience bloodshed. At what point does the flow of blood become successful? To sacrifice for the common good is a noble quality. I think that not everything went to plan, however. Nature itself is very brutal, nowhere moreso in the deprived imaginations of men, especially when they are armed and have no resistance. To lose over a quarter of the population to mass graves and skull mountains must signify a failure of the overall Khmer Rouge movement. I would have been intrigued to see, however, what would have occurred with absolutely no international pressures on Kampuchea. I didn't mention it in the article but there was US involvment in them dropping chemicals on Cambodian farmland. The region was overly susceptible to foreign involvment and the situation with the Vietnamese was a constant threat. In the end China didn't provide the anticipated support that Pol Pot envisaged which ultimately led to the collapse of the Khmer Rouge.
In today's world we see other countries embark on paths not dissimilar to that of Cambodia during the 1970s. Colombia, North Korea and Afghanistan are cases all well worth examining. In analysing a failed state we can perhaps learn more about the world we live in. Cambodia has some harsh lessons to teach and we owe it to the people who suffered and died in Cambodia that we gain an understanding of their situation so that such atrocities will never occur again.
If this article has interested you then you may wish to study the topic further. There is a great film called 'The Killing Fields', the aforementionned book 'The Lost Executioner' plus a biography of 'Pol Pot' by Philip Short, which are all excellent sources of reference and can be easily purchased at Amazon using the links below.
Posted by wezg at 02:31
Labels: angkor wat, cambodia, communism, comrade duch, khmer rouge, killing fields, pol pot, revolution
Sokhoeun Tep said...
I am a Cambodian living in Phnom Penh, a professor and employee. I was shock and heartbreaking to see the picture posted showing a group or KR fighters holding a head. This image can be retrieved by simply typing the word "Khmer" on google search box, which is in its convenience, direct any visitors to the most ugly picture a country should not be linked to. For my country's sake and name, I totally object and denounce the post of this picture, and the individual who posted this. While KR trial is underway, though bumpy or smoothly, this hideous picture serves nothing but the purpose of implication, further misunderstanding, hatred, unnecessary fears on Cambodia, and ultimately affects Cambodia and her innocent and humble people in international stage. The meaning of this should not necessarily be conveyed through this picture. This picture is painting a black name on the future of Cambodia. I strongly requested that this picture be removed from this post. My email: sokhoeuntep@yahoo.com
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'Gods of Egypt' director apologizes for 'whitewashed' cast
The swords-and-sandals fantasy film Gods of Egypt was the latest movie to face accusations of whitewashing, but its director and studio are owning up to the controversy.
The film, which cast white actors such as Gerard Butler (Olympus Has Fallen) and Nikolaj Coster-Waldau (Game of Thrones) as the Egyptian gods Set and Horus, as well as Brendon Thwaites (The Giver) as the Egyptian thief Bek, received online backlash after the character posters and trailer revealed that the majority of the cast was white, except for African-American actor Chadwick Boseman as the god Thoth.
Director Alex Proyas (Knowing, I, Robot) released a statement to Forbes apologizing for the lack of diversity in the casting.
"The process of casting a movie has many complicated variables, but it is clear that our casting choices should have been more diverse," Proyas said. "I sincerely apologize to those who are offended by the decisions we made."
Lionsgate released its own official statement regarding the casting of the movie below:
"We recognize that it is our responsibility to help ensure that casting decisions reflect the diversity and culture of the time periods portrayed. In this instance we failed to live up to our own standards of sensitivity and diversity, for which we sincerely apologize. Lionsgate is deeply committed to making films that reflect the diversity of our audiences. We have, can and will continue to do better."
Gods of Egypt's casting controversy follows a slew of other films such as Pan, Aloha, and Gods of Egypt in which directors and actors both apologized for or defended the casting of white actors in roles that are written as minorities.
However, this is one of the few times that both director and studio have apologized before the movie's release, as director Ava DuVernay noted.
Gods of Egypt tells the story of a mortal (Thwaites) who sets off an a journey to save the world and rescue his true love, enlisting the help of the god Horus to defeat Set, the god of darkness. The film also stars Rufus Sewell, Elodie Young, Courtney Eaton, Abbey Lee, and Geoffrey Rush.
Gods of Egypt opens Feb. 26, 2016.


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