text:
Neurotrophins
医学神经科学
Medical Neuroscience explores the functional organization and neurophysiology of the human central nervous system, while providing a neurobiological framework for understanding human behavior. In this course, you will discover the organization of the neural systems in the brain and spinal cord that mediate sensation, motivate bodily action, and integrate sensorimotor signals with memory, emotion and related faculties of cognition. The overall goal of this course is to provide the foundation for understanding the impairments of sensation, action and cognition that accompany injury, disease or dysfunction in the central nervous system. The course will build upon knowledge acquired through prior studies of cell and molecular biology, general physiology and human anatomy, as we focus primarily on the central nervous system. This online course is designed to include all of the core concepts in neurophysiology and clinical neuroanatomy that would be presented in most first-year neuroscience courses in schools of medicine. However, there are some topics (e.g., biological psychiatry) and several learning experiences (e.g., hands-on brain dissection) that we provide in the corresponding course offered in the Duke University School of Medicine on campus that we are not attempting to reproduce in Medical Neuroscience online. Nevertheless, our aim is to faithfully present in scope and rigor a medical school caliber course experience. This course comprises six units of content organized into 12 weeks, with an additional week for a comprehensive final exam: - Unit 1 Neuroanatomy (weeks 1-2). This unit covers the surface anatomy of the human brain, its internal structure, and the overall organization of sensory and motor systems in the brainstem and spinal cord. - Unit 2 Neural signaling (weeks 3-4). This unit addresses the fundamental mechanisms of neuronal excitability, signal generation and propagation, synaptic transmission, post synaptic mechanisms of signal integration, and neural plasticity. - Unit 3 Sensory systems (weeks 5-7). Here, you will learn the overall organization and function of the sensory systems that contribute to our sense of self relative to the world around us: somatic sensory systems, proprioception, vision, audition, and balance senses. - Unit 4 Motor systems (weeks 8-9). In this unit, we will examine the organization and function of the brain and spinal mechanisms that govern bodily movement. - Unit 5 Brain Development (week 10). Next, we turn our attention to the neurobiological mechanisms for building the nervous system in embryonic development and in early postnatal life; we will also consider how the brain changes across the lifespan. - Unit 6 Cognition (weeks 11-12). The course concludes with a survey of the association systems of the cerebral hemispheres, with an emphasis on cortical networks that integrate perception, memory and emotion in organizing behavior and planning for the future; we will also consider brain systems for maintaining homeostasis and regulating brain state.
Brain, Neurological Disorders, Neurobiology, Neurology
While I greatly respect Dr. White's obvious immense knowledge of the neural anatomy, I feel taking this course did very little beyond showing me that perhaps medicine and anatomy wasn't for me.
I've always wanted to attend a course like this which offers such a detailed description of the fundamentals of neuroscience. Glad I found it and sure as hell recommended it to all my friends.
The Changing Brain: The Brain Across the Lifespan
This module represents another turning point in Medical Neuroscience. Now that we have surveyed human neuroanatomy and our sensory and motor systems, we are ready to take a step back and consider how this magnificent central nervous system came to be the way that it is. We will also learn how the brain re-wires itself across the lifespan as genetic specification, experience-dependent plasticity and self-organization continue to interact, re-shaping the structure and function of neural circuits throughout the central nervous system.
Embryological Subdivisions of the Human CNS8:47
Major Forces In Early Brain Development12:36
Neurulation11:17
Formation of the Early CNS12:35
Inductive Signaling In CNS Formation15:10
Proliferation and Migration, part 117:23
Growth Cones11:42
Molecular Signals for Axon Guidance, part 113:22
Neurotrophins13:08
Neurotrophin Receptors and Synapse Formation11:43
Leonard E. White, Ph.D.
Now I'd like to turn to a discussion of the trophic molecules and consider the nature by which these molecules provide nourishment that promotes the growth and survival of neurons and their processes. And I'd like to take you through a really classic experiment in neuro-embryology done in the first half of the 20th century by two real heroes of mine. Victor Hamburger who did most of his work at Washington University in St. Louis, where I did my own studies. I had a chance to meet Hamburger towards the latter years of his life, and it was a real joy to do so. Viktor Hamburger is a role model for so many reasons. He was a wonderful scientist, but he had a particular perspective on collegiality, which has certainly enriched his legacy for those of us that, that know something about him. Viktor Hamburger. began to be aware of a Italian scientist, a young woman, who was working under extraordinary conditions. Her name was Rita Levi-Montalcini, and Hamburger and Levi-Montalcini, a world apart, were doing very similar experiments, and not always coming up with agreeable findings. And, rather than developing sort of a, competitive, adversarial relationship, Humburger invited Levy Montelcini to join him in his group in St. Louis. which she did, after working through a tremendous hardship in the time of World War II. Well, eventually, Levi-Montalcini and Hamburger together with Stanley Cohen, collaborated in a landmark series of experiments that led to the discovery of neurotrophins, and a deeper understanding of how they impact the development of the nervous system. Well, here's some simple experiments that they performed. It involves the study of the development of motor neurons in the spinal cord relative to the muscles that they innervate. Now as I mentioned in our last tutorial many more neurons are typically produced in each region of the nervous system than, than actually survive. And that's true here in the spinal cord. What we see And the ventral horn, in this illustration in red are those neurons that actually go on to survive their course of development. And green is a population of neurons that are intially produced but die off through a process of prgrammed self death. So why should this be? This was a question that Hambuger wanted to explore. And what was the experiment here, was to take a chick embryo and delete one of the limb buds, which would have, obviously, a dramatic impact on the amount of target tissue that would be available. For the outgrowth and connectivity of the alpha motor neurons on that side of the appropriate enlargement of the spinal cord. So the result of this unilateral limb blood ablation is that on the ipsilateral side of the spinal cord, there's a dramatic reduction. In the population of motor neurons, whereas on the Intact side of the spinal cord, the normal complement of motor neurons survives the process of development. So this suggests that there is something about the presence of target tissue that's essential for their survival of the neurons that normally would come to innervate that tissue. Well, in the chick embryo it's possible to do the complementary experiment. So what Hamburger and his colleagues did was they took a limb bud from one embryo and transplanted it to another, essentially doubling the complement of target tissue that would be available for the intervention of motor neurons from the appropriate segments of the spinal cord. And then after about a week of growth, what was discovered is that, on the side of the embryo, that has the extra limb bud, there are rightly twice as many neurons, that would normally be present. And the control side is the index that allows a conclusion regarding the impact on cell survival from the presence of that extra limb bud. Now one might have imagined that this, these extra neurons were somehow induced through mitotic activity here in the ventral horn following this addition of this extra limb bud. But through a variety of experiments we know that that's not the case. the extra neurons that are present here reflect the survival of neurons that otherwise would have died through programmed cell death. So this suggests that there's some factor that's present and released by target tissue that is essential for the survival of neurons. And that such factors might be important in establishing the appropriate complement of neurons that connect to target tissues. So these experiments allow for two principal conclusions. that there is decreased program cell death. Of a motor neuronal pool with augmentation of target tissue. That is, with the present of an extra limb bud. But it also illustrates that with reduction of target tissue. There's an enhancement of program cell death. Leading to a depletion of those neurons that otherwise could have survived. So this suggest that target tissues release some kind of a substance. We now call that substance a trophic factor that is essential for the survival of neurons. And this substance might actually be quite critical for establishing the appropriate compliment. Of neurons that intervate or target tissue. Now we think that through a variety of other experimental evidences we believe that trophic molecules also operate at the level of individual axonal branches, not just the survival of the entire neuron. And this becomes critical for establishing the appropriate patterns of convergence and divergence as neurons innervate their target tissues, be they targets in the periphery, or targets in the central nervous system. So, here's two examples from the peripheral nervous system. In early development, alpha motor neurons innervate individual muscle fibers. And it's possible to find multiple collaterals from different alpha motor nuerons supplying the very same muscle fiber. So here in this illustration, for example, a single Alpha-motor neuron might send branches that innervate each of 3 individual muscle fibers. And autonomic ganglia, we may see something quite similar. There may be collateral branches from a single preganglionic neuron that innervates multiple postganglionic neurons. Now this is quite intriguing because we know that in the mature nervous system, a single muscle fiber is supplied by a collateral from just one alpha motor neuron. And likewise, a gangleonic neuron that lacks dendrite such as what we have illustrated here. Receives it's synaptic inputs from a single preganglionic neuron. So there's some kind of sorting process that must play out here to establish this appropriate degree of convergence and divergence. And a key mediator. Of this competition seems to be neurotrophins. Well, a variety of studies done in these systems, and others, have given rise to a set of propositions that we sometimes call the neurotrophin hypothesis. So the neurotrophin hypothesis goes as follows. We imagine that In development, the survival of neurons and their axonal connections depends upon the availability of a trophic factor that's present in some minimal quantity. Such trophic factors are synthesized and released by target tissues, and again We think that they're present only in very limited quantities. And this sets up a competitive scenario where the survival of neurons and their specific connections depends upon successful competition for the acquisition of that trophic substance that's present only in limited supply. And in this way we imagine that for that single muscle fiber only one axon can acquire sufficient trophic substance to promote the survival of that connection. Similarly for a ganglion neuron- So that only one preganglionic neuron can acquire sufficient trophic support in order to maintain the viability of that connection. Now, let me just back up for a moment and highlight interesting inaccurate feature of this illustration. Notice that there are fewer connections And these immature, neurons compared to the more mature form. So the overall numbers of synapses is increasing even as competition is playing out in the numbers of inputs, that is the number of individual axon Fibers or axon collaterals that come to innervate given postsynaptic cell is decreasing. So there's a winnowing down of the numbers of neurons that are interconnected. Even while there is a net increase in the numbers of synapses. That are being formed on these post-synaptic targets. So in this autonomic ganglion, there may be a winner-take-all outcome here, such that all of the post-synaptic targets that are available on this ganglionic neuron are now occupied. By synapses that are elaborated by a single pre-ganglionic axon. Okay, let's get back to our neurotrophin hypothesis. So, we've emphasized that in brain development, this is going to be really critical. For mediating competitive interactions among different axons that may be competing for the same postsynaptic targets. We'll see some examples of that in the developing visual system in our next tutorial. But I'd like to just make a, a point. And that is that in the mature nervous system. Neurotrophins remain very important molecules in shaping the structure of circuits in the central nervous system and this is especially true in the context of plasticity following injury. One phenominum that we'll explore later in this unit Is that as nervous tissue is recovering from injury, many of the mechanisms that were important in establishing connections in brain development become reactivated. So many of the, genes begin to express, the substances that were important in building connections in the first place as a means for promoting regeneration and regrowth of connections within the central nervous system. Now, this process is modulated in various ways, we'll eventually come to that, but for now I want to emphasize that neurotrophins remain important in shaping the structure of connections even in the mature brain. And this is especially important in considering how the brain responds to injury and disease. But it's also important in understanding how sensory motor experience can shape connections within the brain, and thereby instill learning. So for example when we acquire a new motor skill. When we practice a sport or a musical instrument or a new dance step. we imagine that there is some kind of plasticity that's taking place. And neurotrophins very well may play an important role in mediating the competitive interactions that we hope Will eventually build a more efficient circuit that will reinforce those patterns of connections that instantiate the acquired skill.


text:
Professionista dal 1985 al 1996, vinse il Giro d'Italia 1988.

Carriera
Passato professionista nel 1985, nello stesso anno vinse una tappa a cronometro al Giro d'Italia. Notato da Bernard Hinault, che lo ingaggiò nella sua squadra La Vie Claire, nel 1986 vinse il Giro della Svizzera ed aiutò il suo compagno e connazionale Greg LeMond a conquistare il Tour de France.

Stanco di fare il gregario, nel 1987 divenne il capitano della 7 Eleven e con essa vinse il Giro della Svizzera nello stesso anno, e soprattutto il Giro d'Italia nel 1988, giungendo secondo il 5 giugno in una tappa storica, affrontando in condizioni estreme i 2.621 metri del passo Gavia. Con la vittoria finale al Giro d'Italia divenne il primo atleta non europeo ad aggiudicarsi la manifestazione.

Arriva terzo nell'edizione del 1989 della corsa rosa.

Nel 1990 vinse una tappa al Giro della Svizzera e nel 1991 passò alla Motorola, con cui nell'anno seguente trionfò al Tour de Romandie, piazzandosi primo anche in una tappa del Tour de France (che concluse al quarto posto). Militò poi nella Banesto e nella US Postal, ma non ottenne più risultati di rilievo e si ritirò dal ciclismo agonistico nel 1996.

Palmarès
 1985
20ª tappa Giro d'Italia (Saint-Vincent > Valnontey)
Cronoscalata della Futa-Memorial Gastone Nencini
Gran Caracol de Montana

 1986
Prologo Tour de Suisse (Winterthur, cronometro)
Classifica generale Tour de Suisse

 1987
Classifica generale Tour de Suisse
11ª tappa Coors Classic
14ª tappa Coors Classic (cronometro)

 1988
3ª tappa Parigi-Nizza (Tolone-Mont Faron)
12ª tappa Giro d'Italia (Novara > Selvino)
18ª tappa Giro d'Italia (Levico Terme > Valico del Vetriolo)
Classifica generale Giro d'Italia
12ª tappa Coors Classic (cronometro)

 1989
2ª tappa Vuelta al País Vasco (La Arboleda)
Subida a Urkiola
Classifica generale Schwanenbrau Cup

 1990
Subida a Urkiola
7ª tappa Tour de Suisse (Unterbäch > San Bernardino)

 1991
3ª tappa Tour de Romandie
Classifica generale Tour de Romandie

 1992
Classifica generale Volta a Galena
14ª tappa Tour de France (Sestriere > Alpe d'Huez)

Altri successi
 1986
Classifica giovani Tour de France

 1988
Classifica scalatori Giro d'Italia

Piazzamenti

Grandi Giri

 Giro d'Italia
1985: 20º
1988: vincitore
1989: 3º
1992: 5º
1993: 14º
1994: 10º
1995: 58º

 Tour de France
1986: 4º
1987: 16º
1988: 15º
1989: 22º
1990: 11º
1991: 8º
1992: 4º
1993: 8º

Classiche monumento

 Milano-Sanremo
1989: 59º
1990: ritirato
1991: 106º

 Liegi-Bastogne-Liegi
1987: 40º
1988: 68º
1990: 56º
1993: 52º
1994: 48º

 Giro di Lombardia
1988: ritirato
1989: 22º
1992: 16º
1991: ritirato
1993: 29º
1995: 52º

Competizioni mondiali
 Campionati del mondo
Giavera del Montello 1985 - In linea: 64º
Colorado Springs 1986 - In linea: ritirato
Villach 1987 - In linea: 45º
Chambéry 1989 - In linea: 34º
Utsunomiya 1990 - In linea: ritirato
Stoccarda 1991 - In linea: 34º
Benidorm 1992 - In linea: ritirato
Oslo 1993 - In linea: ritirato
Agrigento 1994 - In linea: ritirato
Duitama 1995 - In linea: 20º

Note

Altri progetti

Collegamenti esterni

Vincitori del Giro d'Italia
Vincitori del Giro di Svizzera

redpajama_set_name: RedPajamaWikipedia


"The one dollar bill is the most ubiquitous piece of paper in America. Collage asks the question: what might be done to make it something else? It is a ripe material: intaglio printed on sturdy linen stock, covered in decorative filigree, and steeped in symbolism and concept. Blade and glue transform it-reproducing the effects of tapestries, paints, engravings, mosaics, and computers—striving for something bizarre, beautiful, or unbelievable... the foreign in the familiar."
"The Bulgaria-born Stefan Kanchev (1915-2001) was a designer who led the applied graphic design scene of Europe from the 1940s to 1990s, throughout Postmodernism and into contemporary times.
His prolific works related to various visual design fields, from posters to stamps and videos. In particular, Kanchev was at the forefront of logo design, having personally designed over 2,000 logos during his illustrious career. Not only is his oeuvre magnificent in terms of quantity, but its exceptional artistic quality and degree of perfection well demonstrates Kanchev's ingenious talent. Although he was one of the most distinguished designers during a period when graphic design flourished, his name remains rather unfamiliar in design history. Kanchev was a designer veiled behind his creations, as more people remember him for his logos than his name.
A member of graphic design organizations, including AIGA in the U.S. and ICTA in the U.K., Kanchev was discovered internationally for the first time when he was introduced in the Japanese design magazine Idea, in 1994. Today, Kanchev is regarded one of the most significant logo designers, along with Otl Aicher, Anton Stankowski, and Paul Rand."


text:
China warns US of 'all necessary measures' over Huawei rules 43 minutes ago
BEIJING (AP) — China's commerce ministry says it will take "all necessary measures" in response to new U.S. restrictions on Chinese tech giant Huawei's ability to use American technology, calling the measures an abuse of state power and a violation of market principles.
An unidentified spokesperson quoted Sunday in a statement on the ministry's website said the regulations also threatened the security of the "global industrial and supply chain."
"The U.S. uses state power, under the so-called excuse of national security, and abuses export control measures to continuously oppress and contain specific enterprises of other countries," the statement said.
China will "take all necessary measures to resolutely safeguard the legitimate rights and interests of Chinese enterprises," it said.
Under the new rules, foreign semiconductor makers who use American technology must obtain a U.S. license to ship Huawei-designed semiconductors to the Chinese company.
Chip design and manufacturing equipment used in the world's semiconductor plants is mostly U.S.-made, so the new rule affects foreign producers that sell to Huawei and affiliates including HiSilicon, which makes chips for supercomputers with scientific and military uses. The U.S. Commerce Department said foreign foundries would be granted a 120-day grace period for chips already in production.
[link to apnews.com (secure)]
Re: China warns US of 'all necessary measures' over Huawei rules 43 minutes ago
China threatens over Coronavirus investigations, China threatens over their spying Huawei corporation, China is true ashoe, need to be nuked.
China's Planned Retaliatory Steps Against New US Crackdown on Huawei May Come as 'Nuke Bomb'
On Saturday, Beijing urged the US to halt the "unreasonable suppression of Huawei and Chinese enterprises" following Washington's announcement of new export controls to restrict the tech giant's access to American semiconductor technology.
The state-run Chinese newspaper Global Times has cited unnamed analysts as saying that Beijing's planned retaliatory steps against Washington's intention to clamp down on shipments of semiconductors to Huawei may be likened to a "nuke bomb" in terms of effectiveness.
"The forceful countermeasures" will reportedly include a crackdown on a number of large US companies, such as Qualcomm, Cisco, and Apple as well as the American plane maker Boeing.
"China will launch rounds of endless investigations on those firms, just like swords hanging over their head. It will dampen investors' confidence and squeeze their income in the Chinese market", an unnamed source told the Global Times, adding that "it will also inflict a chain reaction on various upstream and downstream players in US chip production".
The source was echoed by He Weiwen, a former senior trade official and an executive council member of the China Society for World Trade Organisation Studies, who told the newspaper that Beijing "should implement these countermeasures to the extent that the US dare not ask for a mile after being given an inch".
He urged the Chinese government to conduct "thorough investigations into relevant US companies" and "let them feel the pain".
[link to sputniknews.com (secure)]
Moses Born Again in L.A.
Moses Born Again
China sucks but I'm more worried about their assets in the West, the MSM, the universities, the Democrats, etc.
China has been violating patent and copyright laws for decades ripping off major companies like APPLE creating fakes and using the designs and intellectual property of other corporations to make money off their own counterfeit goods.
PrisonerNo6
Beware the threats within...
its not just Apple they rip off either. its Many many American corporations.. Fender, Gibson and such you can go on chinese ebay sites and pick up fake fender stratocasters that imitate every detail.. Thats just one example they basically blanket ignore all copyright and see other companies products as a resource they can copy and cell under the same name,logos and design.
china should be taken down.
Fuck China, they should be nuked right now
Evil controls the ignorant... Climate change is a hoax so is the vax you have been fear-porned into compliance!
Definition Satan from the bible: Satan (Rev 12:7) exercising his subtle (indirect) impact on heathen governments (powers) – i.e. accomplishing his hellish agenda from "behind the scenes."
Quoting: Jake
Yes x 35
Nonentity
Chinese spy on foreign militaries with tech backdoors.
Though, I think the US knew and fed them BS
TheElephantInTheRoom
Sigh. These pieces of shit really want to terrorize mankind so that they can try to control all of it. Well, I for one am sick of their long games and hope they get resisted from more than the just USA. We're all Fucking reeling because of the poison they spread throughout the world. I hope each country stands up to these monsters/bullies.
Chinese government has rabies.
Vicious Deplorable dollop
You ain't seen nothing yet!
Fuck a bunch of Chicoms.
Bomb all their water treatment plants and dams and they're all dead in three months... They've poisoned their own country so bad.
Last Edited by Vicious Deplorable dollop on 05/17/2020 08:46 AM
Kamala Harris is not a Natural Born Citizen. She's illegally running.
Used by the Founders...
Book I of The Law of Nations, Chapter XIX, § 212 (Joseph Chitty numbering) – "Citizens and natives"
reads: 'The citizens are the members of the civil society; bound to this society by certain duties, and subject to
its authority, they equally participate in its advantages. The natives, or natural-born citizens, are those born in
the country, of parents who are citizens. As the society cannot exist and perpetuate itself otherwise than by
the children of the citizens, those children naturally follow the condition of their fathers, and succeed to all
their rights.' 1758 Emerich de Vattel
Oh' What the Hell, do I look like I want to die in some nursing home one day...
America must have 4 new Constitutional Amendments...
1. Drug Tests and Mental Evaluations on all politicians and judges randomly five times per year.
2. Term Limits for Federal politicians and judges.
3. Mental and health standards for Supreme Court Justices and retirement age set.
4. A 'Star Chamber' of elected Natural Born Citizens (no attorney's) to ivestigate, try, and prosecute the politicians and government employee's as they see fit.
Mandatory death penalty by public hanging is the merciful sentence for pedos and their associates.
Democrats are a WMD, literally.
Let Justice Be Done Though The Heavens Fall.
China is assHOE!
Nighthaven
It is laughable that China has the audacity to do and say such things considering they're the #1 source of all fakes, replicas and cheap knock-off merchandise.
Unfortunately, they've got their tentacles firmly wrapped around so many corporations that use greed to ship what should be American jobs overseas. It disgusts me to see this happen so often in the pursuit of cheap labor and higher profits but, being the Devil's advocate here, that's what any company would do if presented with the promise of high profits and low wages versus the opposite. Yes, it would be wonderful to keep the work here in the States but you all know as well as I do that if you're an entrepreneur looking to hit it big and you can get that by using Chinese resources you'd do it. Don't deny it. This mainly applies to major corporations, by the way, so small- to medium-sized businesses would likely still use labor and materials from here since it wouldn't be cost effective to go overseas. But I'm no business major so I could be wrong.
Bottom line: China sucks and they don't deserve anything we give them but companies have empowered them so much that you'll never see them give up their holdings there.
I hope they destroy our electrical grid so we can finally get the SHTF scenario that all of us have been hoping for.
IM YOUR HUCKLEBERRY
Drag that evil known as the CCP into international court and bring charges of crimes against humanity. The CCP is directly responsible for millions of deaths worldwide because of the Wuhan coronavirus.
War is coming
Hiram's Apprentice
***THIS***
And not only do they shamelessly clone our own patented and copyrighted designs, they even knock-off their own shoddy products.
They've been caught time and time again stealing intellectual property, spying through back-door technology, poisoning other nations food and pet food products destined for international sale... and now have a problem with being held accountable? Personally, I think it's well past time for an all-out global blockade against ALL imports and exports through China. Cut them off completely from EVERYTHING, cut them out of all global commerce, let them burn themselves out, then use the already-polluted Chinese mainland as a global landfill to dispose of all the CRAP they've made over the last fifty years for the next five centuries.
"... Shall not be infringed."
Notice the period at the end? It means END OF CONVERSATION!
Bright Side
Exactly. Why doesn't this administration make an emergency executive order barring any foreign money or investment while we are in this COVID war see how quickly our world changes.
You're the only one who gets to choose your vision... is the glass half empty or half full?
Ps.55:22 Give your burdens to the LORD, and he will take care of you. He will not permit the godly to slip and fall.
The only slight problem being that that would kill tens of millions of innocent people while the real enemy, the CCP, would sit in a bunker nice and safe.
Taiwan numba 1!!!
F00LIO
The Chinese are getting out of hand. It might be time for a small scale shooting war, maybe sink half their navy or destroy all of their naval bases. As far as I'm concerned threats like these are as bad as North Korea's.
I think trump is totally under Xis skin.
FOOLIO
Dub One
The are not Chinese assets, China is more of a 'handler.' China is used to corrupt key players in foreign governments and international organisations as part of the bigger NWO picture.
The NWO is the promotional, selling name for the hidden master's end plan.
Earth is being transitioned from life park to human cattle farm.
That is the plan anyway. Not going too well since Operation Sea Eagle failed. But that is another story...
Weyoun
No. Our nukes have massively advanced and we have surgical ones. Your idea of nukes is still stuck in the 50s.

redpajama_set_name: RedPajamaCommonCrawl


In the 5-6th episodes of The Flame's Daughter Chinese Drama, Lie Ruge cancels she and Zhan Feng's marriage after knowing he doesn't love her at all. Yin Xue takes her leaving flame house, but Yan Niang tells Yu Zihan that Yin Xue is a monster who lived over 100 years.
Lie Ruge blocks Ying Yi's way and asks why she frames her, Ying Yi accepts she has martial art and thinks Lie Ruge is smarter than her imagination. Lie Ruge is unexpected that Ying Yi is so dark and thinks her to help her know Zhan Feng's real face.
Ying Yi hates Lie Ruge as she is the host of maple house if Lie Ruge isn't Lie Mingjing's daughter. Lie Ruge decides to give Ying Yi a gift and gives her a slap, asking what her feeling. Ying Yi has to lie on ground and touch her face, because the maids are looking at her.
Yin Xue becomes weak because of cold gas and want to attend the dinner of flame house to protect Lie Ruge. She is scared and asks him if she should attend. He takes her bowl and drinks it and thinks others will suspect their relationship when she wants to stop her.
Lie Mingjing announces that he is going to marry his daughter to Zhan Feng at Double Ninth Festival, Zhan Feng rejects it. Lie Ruge says that she doesn't like Zhan Feng anymore before Lie Mingjing gets angry. Yin Xue tells everyone that Lie Ruge falls on him. Lie Mingjing thinks she shouldn't help Zhan Feng, Lie Ruge tells her father that she just helps herself.
Yi Lang wants to remove Zhan Feng's martial art and drive him away as he rejected teacher's offer, Lie Ruge lets him treat her instead of Zhan Feng. Yin Xue thinks it was just father and daughter and she didn't break flame house's rule.
Lie Ruge visits maple house with gift Zhan Feng sent to her and asks him if he loved her, he doesn't reply her and thinks she shouldn't return. She gives the gift to him and claims they are stranger from now on, he opens the box and find the lotus flowers which he planted.
Die Yi and Xun Yi tell Lie Ruge that Yin Xue prepare stuffs of Double Ninth Festival for her, he lets her taste the cayenne pepper which he made for her after she visits his house. Yin Xue willfully lets Lei Jinghong blow the pepper on Dao Liexiang's face.
Dao Liexiang asks Die Yi and Xun Yi about Lei Jinghong's younger sister, and takes them to see him. Although Die Yi fits the condition of his younger sister, she doesn't have birthmark on her left ear. Zhan Feng gets angry and doesn't allow to celebrate Double Ninth Festival at maple house when Ji Jinglei is setting up.
Dao Liexiang asks Lei Jinghong why he didn't recognize Die Yi as his younger sister, he reveals he wants to protect her. Yin Xue shows flame to Lie Ruge and thinks it's beautiful but evil when she asks him.
Feng Xixi sees Huang Zong off and asks him when Yu Zihan will return, Huang Zong calms her down and reveals he will come within a few days. She gives him the snack which she made yesterday. Yu Zihan visits Lie Mingjing and persuades him to protect himself after he received a letter.
Lie Ruge visits Yu Zihan with chrysanthemums she picked from mountain after knowing he is going to leave, he lets her take care of herself and tells her he is her senior no matter where he is. She worries about he will be bullied after he goes home and gives wind chimes to him.
Prince Jing Xian visits Feng Xixi who is shocked after seeing him, Phoenix worries Feng Xixi when hearing voice which comes from her room. Lie Mingjing wants to give flame token to Lie Ruge, but she thinks her father is too rash. Dao Wuxia gives ice lamp to Prince Jing Xian and tells him that Yu Zihan will get sick if he keeps it.
Yu Zihan gets angry after knowing Prince Jing Xian killed Feng Xixi and lets Huang Zong investigate it. Lie Ruge decides to leave flame house and begins to improve her cooking skill after knowing his father wants her to be the master of flame house.
Yin Xue accepts to help Lie Ruge leave flame house but he wants to leave with her. He visited Lie Mingjing who let him take his daughter to immortal realm before leaving. Emperor gives ice lamp to Yu Zihan and sends the doctor Yan Niang to treat his broken ears, Prince Jing Xian warns Yu Zihan not to investigate his case.
Yu Zihan asks Yan Niang why she has to hunt Yin Xue, she tells him that Yin Xue is a monster who lived over 100 years. Yu Zihan lets Huang Zong protect Lie Ruge even if he doesn't believe what she said. Yu Zihan can hear the voice which comes from wind chimes after the treatment from Yan Niang. He promises to keep the fame of thunder sect as long as they don't hurt citizens.


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The Mindful Cardiologist
Abby Weingarten
Paying Wellness Forward
https://www.srqmagazine.com/articles/1434/Paying-Wellness-Forward
chippyajithan
Chippy Nalluri, M.D., F.a.C.C.
Board-certified cardiologist, Heart Specialists of Sarasota.
Dr. Chippy Nalluri's true passion revolves around patient education.
Dr. Chippy Nalluri, a board-certified cardiologist, is quite the rarity, being the only female in a group of highly skilled cardiologists at Heart Specialists of Sarasota. She grew up in Chicago with parents who emphasized the importance of education and work ethic, and graduated from the University of Illinois, Champaign-Urbana. She attended medical school in Chicago at the University of Illinois. Her love for cardiology began during residency at Case Western Reserve University. She begin practicing in Florida in 2002 and is trained in all aspects of cardiology including board certification in cardiovascular diseases and nuclear cardiology. A fellow of the American College of Cardiology, she has been named to Top Doctors by Castle Connolly. She is on active staff at Sarasota Memorial Hospital and a clinical assistant professor at Florida State University Medical School.
Dr. Nalluri cares for critically ill hospitalized patients and office patients, providing advanced evidence-based therapies. She enjoys the role of a cardiologist managing the full range of cardiovascular medicine from chest pain and arrhythmias to complex valvular heart disease and heart failure. Her true passion, however, revolves around patient education. She empowers each individual to make positive changes towards a healthier lifestyle. Die in health, not sickness, is her motto. She has given many lectures to groups and health care organizations educating preventive efforts and has worked with Go Red for Women to increase awareness that heart disease is a woman's No. 1 killer. Recently she appeared on a charity calendar project, Saris to Suits, raising money and social consciousness about the plight of battered women. The efforts were recognized through her interviews with TV Asia, BBC and Fox News.
Sarasota-Article-Chippy2020
#themindfulcardiologist_srq #wellness
©2020 Dr. Chippy - The Mindful Cardiologist


Thanks to the Event Horizon Telescope Collaboration, we have been able to see the first ever image of a black hole at the center of a galaxy known as M87.Almost two years ago, we lost Chris Cornell. He was the lead singer for Soundgarden and Audioslave, and above all, the voice of an entire generation. He was one of the most beloved figures not just in rock, but all of music, by people from all over the world. His music, his voice and his personality inspired, influenced, changed and even saved the lives of thousands of people. Chris left a heavy legacy for a new generation of musicians who follow in his footsteps. His memory will remain forever alive in the hearts of all his family, friends, fans and all the people who love him, and his music will do the same in each record, song or video we play. Black Hole Sun, written by Chris Cornell is without a doubt Soundgarden's most recognizable and most popular song, and one of the biggest anthems of the '90s. For this reason, and the impact Chris Cornell had in the lives of so many and music itself, I ask NASA, the Event Horizon Telescope Collaboration and all the astronomers and scientists involved in this discovery, to name this black hole after Chris Cornell. This would be a "surreal" and amazing way to honor his life and his contribution to music.
Chris Cornell's Higher Truth Solo Acoustic Tour at the Sheldon Concert Hall in Saint Louis, MO on December 18th, 2015.


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A new study has integrated neuroscience and psychological research to reveal how sleep is more complex than previously imagined.
The Scripps Research Institute (TSRI) research shows in animal models that sleep suppresses the activity of certain nerve cells that promote forgetting, insuring that at least some memories will last.
Senior author Ron Davis said that many scientists have tried to figure out how we learn and how our memories become stabilized, but far less attention has been paid to forgetting, which is a fundamental function for the brain and potentially has profound consequences for the development of memory therapeutics.
He noted that the current study merges the neuroscience of forgetting, that is, the brain mechanisms that lead to forgetting, and the psychology of forgetting into an integrated picture.
The new study in experimental animals reveals the biological underpinnings of the earlier psychology studies, pointing to the activity of the neurotransmitter dopamine. Dopaminergic activity is known to regulate various types of "plasticity," the ability of the brain to change in direct response to learning and memory formation. That ability includes forgetting as well.
The study shows that increasing sleep, with either a sleep-promoting drug or by genetic stimulation of the neural sleep circuit, decreases signaling activity by dopamine, while at the same time enhancing memory retention. Conversely, increasing arousal stimulates dopamine signaling and accelerates forgetting.
Davis noted that this signal activity isn't constant but is tied directly to the animal's arousal level, adding that sleep reduces the forgetting signal in the brain, thereby keeping memories intact. As sleep progresses to deeper levels, dopamine neurons become less reactive to stimuli and this leads to more stable memories.
The study is published online ahead of print by the journal Cell.


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Atletico's Diego Simeone and Koke address the media
Simeone and Koke: "We will have to fight"
The coach and the midfielder speak: "We will need to play with intensity and humility"
Diego Simeone and Koke sat in their press conference at Allianz Stadium on the eve of the second leg of the Champions League round of 16 tie. They had these words to say.
We will have to take advantage of the spaces that will be granted to us, Morata can be important in this sense. Godin will be fine and I think that he will be available. Juventus is a very strong team, with important strikers, not just Ronaldo. We will have to pay close attention to everyone and fight from the first minute.
What worries me the most about tomorrow's match is how we will play. We will have to put a lot of intensity on the pitch. They have an excellent air game, they press a lot and they will attack in every way, but we too will have to start strong and play strong. At Wanda, we played great and we want to repeat here, even if we know we are facing a great team.
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Our 2000 model Chevy Astro van has 261,900 miles on it. Although she is still running strong, we have decided to let her rest for awhile and only service the local Metro Atlanta area.
We purchased this 2017 Ford Transit for our long trips and far away customers. We will have the logos and signage put on it soon. The art work is in and has been approved. We will post a picture of it when it is all finished. At this point we service Grandfather clocks in homes from Chattanooga down to south Atlanta. We will be looking into expanding our service territory in the near future. We hope to start servicing Grandfather clocks from Charleston, South Carolina down through Savannah Georgia. With this new van it will make the long trips well worth the drive.
We will let everyone know in the Charleston South Carolina area when we are ready to come down to provide Grandfather clock house calls in your area.


HTC's Vive VR division unveiled the Vive Focus Plus standalone VR headset last month. At the company's annual Vive Ecosystem Conference (VEC2019) conference in China, Vive has now announced that the new VR headset targeted at enterprise customers will hit the shelves on April 15 carrying a price tag of $799 (around Rs. 50,000). The Vive Focus Plus VR headset will be up for grabs from the official Vive website and will initially be available in 25 countries. Upon its market arrival, the standalone VR headset will have support for 19 languages.
Launched back in February, the Vive Focus Plus is an enterprise-focused version of the Vive Focus standalone VR headset that was unveiled last year. The Vive Focus Plus will ship with a host of enterprise features such as Kiosk Mode, Gaze Support, and device management tools for remotely managing, monitoring, and enrolling multiple devices simultaneously. In some of the markets, the standalone VR headset will come bundled with an enterprise license at no additional cost.
The Vive Focus Plus runs on the in-house Vive Wave Platform. In the initial stages of the headset's market availability, users will have access to around 250 Vive Wave applications. Moreover, the Viveport Infinity subscription program will bring 70 premium titles to the table. As mentioned above, the Vive Focus Plus standalone VR headset will be available from the official Vive store starting April 15 priced at $799 (roughly Rs. 50,000).
Talking about the features, the Vive Focus Plus features Fresnel lenses for enhanced visual clarity, higher sharpness and minimal screen door effect. The headset will come with dual 6DoF controllers – a significant improvement over the 3DoF controllers for the Vive Focus headset – and also offers multi-mode capabilities, which makes it compatible with PCs, smartphones, game consoles and video streaming devices like a 360-degree camera.
The new Vive offering packs a 3K (2880×1600 pixels) AMOLED display and is powered by the Snapdragon 835 SoC paired with 4GB of RAM and 32GB of internal storage. The headset has a 110-degrees field of view and comes equipped with a 4,000mAh battery that has support for QuickCharge 3.0 fast charging standard. The Vive Focus Plus comes with an inbuilt speaker and has support for inside-out 6DoF tracking, just like the Vive Focus standalone VR headset that went on sale globally last year.


WJFW is a television station in Rhinelander, WI that serves the Wausau - Rhinelander television market. The station runs programming from the NBC network and identifies itself as "NBC 12". WJFW is a digital full-power television station that operates with 316 kilowatts of power and is owned by Northland Television.


The Board of Education has established the Artists for Kids® 1 (AFK) in order to build a lasting legacy for visual arts programs for the children of British Columbia. The Board has delegated the management of the Artists for Kids to the Artists for Kids Management Committee.
The Artists for Kids is made possible through the generous cooperation of some of Canada's finest artists. The Artists for Kids has secured the right to sell original prints created by the artist patrons. The proceeds of these sales provide funds that are utilized to purchase and maintain a permanent collection of contemporary Canadian art and to support visual arts programs for students.
To operate and program the Gordon Smith Gallery of Canadian Art in collaboration with the Gordon and Marion Smith Foundation for Young Artists 2.
In the event of dissolution of the Artists for Kids, any assets remaining after the satisfaction of the Artists for Kids' liabilities shall remain with the Board of Education for the purposes of maintaining the permanent collection owned at that time.
Up to three persons representing the community and expressing interest in advancing the objectives of the Artists for Kids.
Appointments to the Artists for Kids Management Committee shall be for a two (2) year term. At the discretion of the Board of Education, the term may be extended for a third year.
Directors may be appointed for a maximum of two (2) consecutive terms but then must cease to be a director for at least one (1) year before being eligible for re-appointment.
Where a vacancy occurs during the appointed term, the Board may determine that a vacant director's position shall have a term of one (1) or two (2) years. The length of such term shall be at the Board's discretion.
The Artists for Kids Management Committee shall meet regularly at the call of the Chair or at the request of a majority of the directors. A quorum shall be a majority of directors.
The Managing Director shall be supervised by the Superintendent and shall receive remuneration in accordance with the relevant contract of employment.
The Artists for Kids Management Committee shall, in the spring of each year, recommend to the Board of Education a budget of expected revenue and planned expenditures for the following financial year, and shall, in the fall, submit an Annual Report to the Board. The Annual Report shall cover the preceding financial year and include a statement of finances, programs/services provided, a summary of acquisitions, sales, marketing, and development activities.
The Artists for Kids Management Committee may, from time to time, establish ad hoc committees and shall define the terms of reference, composition and duration of such committees.
No director, save the Managing Director, shall receive remuneration for his or her services on behalf of the Artists for Kids. Directors shall be reimbursed for out-of-pocket expenses incurred while carrying out authorized activities of the Artists for Kids.
The financial year of the Artists for Kids shall begin on the first day of July and end on the thirtieth day of June. The financial operations of the Artists for Kids shall be in accordance with accounting principles generally accepted for British Columbia school districts as prescribed and permitted by the Ministry of Education.
2 The Gordon and Marion Smith Foundation for Young Artists is a non-profit, tax-exempt, charitable organization. It was established in 2002 to support the Artists for Kids education program and the Gordon Smith Gallery of Canadian Art.
The Foundation supports visual arts programs, enrichment opportunities, and scholarships for students. It provides funding for the acquisition of contemporary Canadian art to serve as educational resource materials for students in the School District and a permanent and accessible visual arts collection for the North Vancouver City and District communities.


If you have only got into food blogging fairly recently, there is a good chance that you have been writing lots of reviews and opinions featuring your local restaurants. This is a brilliant place to start of course, but in time you'll find that you'll want to broaden your horizons and treat yourself to some authentic cuisines overseas!
Ah, the sweet smells of crepes and macarons – Paris is surely one of the most easily accessible places abroad for UK bloggers to enjoy. Simply get on the Eurostar or board a plane and soon enough you will be in the land of frites, frogs and flambé'. Every mealtime is an adventure in the French capital, so you won't be disappointed whether you're out for breakfast, lunch or dinner. Take loads of photos and you will have plenty of material to work with when you are able to get online to update your blog.
For a completely different taste sensation, Marrakech might be just what you are after. It is all about spices, flavours and seasoning combined with simple ingredients including meat, fish and vegetarian options. You will be able to wander the streets on the hunt for food cooked at stalls in the ancient squares; you won't be able to resist when you smell the amazing aromas. There are also some high class restaurants where you will be able to discover a true tagine made with lamb or chicken. It is a good idea to look for hotels and riads in Marrakech that have Wi-Fi so you can get online to share your adventure.
Pizza, pasta, gelato and olives – need we say more? Get up close and personal with the simple flavoursand tastes of Italy in the beautiful city of Rome. It will amaze you how many hidden gems there are in a location like this, all you need to do is wander down the alleys away from the major tourist attractions. The best thing to do is to find an apartment in one of the amazing food quarters and you will be able to try things as and when you get hungry. Don't pass up the opportunity to taste a few local wines as well as they are simply stunning.
Finally, if you want to add a little spice to your life, try San Antonio in Texas for size. Here you will find the self-professed capital of Tex Mex cuisine, and wow does it pack a punch! One night you could chow down on some quesadillas, and the next you might have the most mouth-watering ribs covered in a smoky glaze. You will probably want to keep coming back for more as no Tex Mex will ever taste quite so authentic after a trip to San Antonio!


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DOC SPOTLIGHT: Utah Film Center's 15th Anniversary
Written By Diana Whitten
The Utah Film Center celebrated its 15th anniversary last week with a gala on the courtyard of the Leonardo, al fresco sunset dinner, a live auction, and jazzy music by the Gold Standard Band. The evening was to honor the center's co-founders Geralyn Dreyfous, Kathryn Toll, and Nicole Guillemet, and to toast to a decade and a half of engaging and inspiring Salt Lake audiences with film.
It seems fitting to turn the Doc Spotlight on the Film Center at this moment, and reflect on the visionary local enterprise that grew large alongside the documentary zeitgeist, championing doc film over an era when the genre came into its own.
The genesis of the Film Center was at Sundance, 2001 – at a time when documentary was hovering shyly in the fringe, about to be discovered. Geralyn and Nicole were relatively new to the documentary space, and working with the festival's House of Docs initiative to bring filmmakers from around the world to Sundance. Their work caught the eye of early supporters Lon Watson of the George S and Dolores Dore Eccles Foundation and Susan Swartz, who together offered a substantial donation to expand the initiative into a year-round program. Various stars aligned to broaden the concept from a Sundance program to an independent venture, and Geralyn – hands already full with her first film and second child – found herself at the helm.
The initial idea was simple: curate and exhibit thought-provoking, relevant documentary film for Salt Lake audiences. It was a win-win, as Geralyn describes in interview, "Utah audiences had grown up with Sundance in their backyard, and had developed a taste for sophisticated cinema. Filmmakers were hungry for exhibition and audience, and the community here was hungry for cinema."
Geralyn quickly partnered with Kathryn Toll, who at the time was new to Utah and who, in her words, had "spent – or rather misspent – [her] life in the movie business." Like any start-up worth its' salt, the team quickly set up shop in their cars and local coffee shops, and began designing what Katherine lovingly describes as a "freewheeling operation with no rules" – one that nevertheless within the first year had screened an impressive 56 films. By 2002, they had moved into their first legit office, in the newly constructed SLC library, a vibrant downtown hub Geralyn recalls as "a wonderful place to incubate."
During her toast to the Center at last week's gala, Geralyn shared a memory from these early days, of accompanying her young son Jake to get his first library card, and his reasonable analysis of the library's mission: "so the books are free? That is not a good business model, Mom." Cost-effectiveness aside, the Film Center embraced a similarly democratic mission of extending public access to art and culture. From the get-go the screenings were free to the public – as are 86% of the programs the Film Center currently offers.
The goal was not only to connect audiences with cutting edge social documentary, but to involve them. As Geralyn describes, "It was very clear from the beginning that we had hit a nerve in the community; people were really hungry to come together communally, and for this idea of cross pollination." The team built up audiences via online engagement; booked films that tackled tough social issues, and then partnered the screenings with Salt Lake organizations to demonstrate a local connection to the issues in the films. Geralyn recalls, "It was exciting to pack houses, exciting to have partnerships, and people were so appreciative to be given a chance to be part of the platform – Planned Parenthood, United Way, the YWCA. We were always looking to shine a spotlight on the unsung heroes in our community and how they connected to the programming of the film. That seemed like our secret sauce, and I felt that was the future of exhibition."
One such partnership was with the Utah Price Center, which led to the development of the Damn These Heels festival, currently gearing up for its 15th year. For the festival, the Center sought films that would help normalize LGBTQ relationships for straight people and families. Geralyn describes, "telling these stories of love and friendships was a way to help people not be afraid of the LGBTQ love story." It remains the only LGBTQ film festival in Utah.
Parallel to the growth of the Film Center, the doc world has grown in stature and influence to become a thought-leader of our time. When considering the future of the center she co-founded, Geralyn has an eye toward artistic innovations in documentary, like VR and other experimental interactive exhibition, but also a focus on effectively respecting the responsibility that a curator of nonfiction now carries. She says of curating, "You have to be thinking ahead and really see some of the emerging issues that the community may need to think out loud together about." Like all conscientious nonfiction media makers, those in the doc world find themselves at a necessary crossroads of introspection, given the current political climate. Geralyn sees the Film Center as having a role in this: "the future is really scary for media literacy, and we have to spend a lot more time helping consumers understand the media they are consuming – whether it's over the internet, news or films, because there will be more and more technology that allows people to manipulate the truth. I feel that the Film Center needs to be right at the center helping to educate audiences." In a disorientating time when war is peace, ignorance is strength, and fake news buys summer homes, doc filmmakers – often embedded for years in their subjects – have the opportunity to be guardians of accountable media. Media gatekeepers with ideologies like the Film Center ensure their work is enabled and seen.
Three offices and one devastating fire later, the staff of the Film Center has grown to 17 people. Since 2002, they have presented over 2000 free film screenings in multiple venues across the city and state, working with 94 community partners, and hundreds of filmmakers – 64 visiting artists and local guests participated in 2016 alone. Guests from past years include luminaries like Albert Maysles, Frederick Wiseman, Alice Walker, Lucy Walker, Rory Kennedy, Steve James, and Stanley Nelson, and the staff are currently working on cataloguing the Q&As to post a selection of them online over the coming year.
Their mission has expanded into three pillars: the Curated Film described above, Media Education, and Artist Support; with their education department reaching close to 20 thousand students and 450 teachers trained to date; and fiscal sponsorship extended to over 100 films, 4 of which garnered Academy Award nominations. "We've strived to stay true to the vision of our founders by continuing to present films that illuminate the human condition and the times we live in, as well as pushing the artistic boundaries of non-fiction film storytelling," says Patrick Hubley the Film Center's Director of Programming since 2009. "Our curated film programs have expanded to include our Tumbleweeds Film Festival to introduce young audiences to international and independent films including documentaries, and presenting films in 5 other cities in Utah. We're excited about the future and are continuing to look at how we can expand our reach to show more films and exploring opportunities to bring our programming to new communities."
Moreover, as the Film Center both brings art and artists to Utah, it reciprocally helps showcase Utah to the world at large. Says Geralyn: "I really love challenging the stereotypes that outside artists have about screening a film in Utah. Filmmakers come to Utah and see how sophisticated and appreciative audiences are, and also how full they are! That means a lot to a filmmaker, when they come, and people show up."
Speaking as a filmmaker whose first experience with the Beehive State, just barely three years ago, was the screening of my documentary at the Utah Film Center, I can attest to this positive filmmaker experience. Since that evening, I've traded the New York City sidewalks for Salt Lake's mountains, and I'm part of that local Salt Lake audience. And so, as is commonly heard around the Film Center offices, see you at the movies!
Contributing writer, Diana Whitten, writes, makes art, and directs film.
Utah's in Vogue


Want to win big money online? Jackpot slots are where it's at. What other game gives you a chance at winning thousands or millions of dollars for a quarter per spin?
When we say millions, we're talking about games like Mega Moolah. These slots drop their payload once every few months – as exciting as that is, it's not enough for some.
If you place yourself in the latter group, you'll want to check out daily jackpot slots. As the name suggests, these games award their jackpot every day, without fail. Correspondingly, their top prize is smaller, but with 365 winners per year as opposed to a handful, does it matter?
There's no better time than now to try them out, as LeoVegas is sweetening the pot even further. Read on below for the details.
From now to the end of March, LeoVegas is hosting a promotion called 'Double Jackpots'. This promo does what it says on the tin – it doubles the jackpots of selected Red Tiger slots.
There is one little catch, though – if the amount exceeds $5,000, they cap their contribution at $5,000. For instance, if you trigger the jackpot on Reel Heist for $6,000, you'll take home $11,000, not $12,000.
What does it matter, though? That's still a decent chunk of change – enough to wipe out bills and go on a trip. Want to try your luck? You have until March 31, so jump on LeoVegas and make it happen!


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Home > Islands > Isle of Wight > Sports > Swimming
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Men's 1500m Freestyle View View View View 29/06/2009 18:02:02
Women's 400m Individual Medley View View View View 29/06/2009 18:10:20
Men's 200m Butterfly View View View View 29/06/2009 18:14:25
Women's 100m Butterfly View View View View 29/06/2009 18:23:22
Men's 100m Breaststroke View View View View 29/06/2009 18:27:14
Women's 50m Breaststroke View View View View 29/06/2009 18:37:42
Men's 50m Backstroke View View View View 29/06/2009 18:46:59
Women's 200m Freestyle View View View View 29/06/2009 18:50:14
Men's 200m Individual Medley View View View View 29/06/2009 18:56:46
Women's 4 x 50m Freestyle Relay View View View View 29/06/2009 19:11:47
Men's 4 x 50m Medley Relay View View View View 29/06/2009 19:14:26
Women's 200m Breaststroke View View View View 30/06/2009 17:42:48
Women's 100m Backstroke View View View View 30/06/2009 17:56:47
Men's 50m Breaststroke View View View View 30/06/2009 18:03:09
Women's 50m Butterfly View View View View 30/06/2009 18:08:14
Men's 200m Freestyle View View View View 30/06/2009 18:22:26
Men's 4 x 50m Freestyle Relay View View View View 30/06/2009 18:54:59
Women's 4 x 50m Medley Relay View View View View 30/06/2009 18:57:05
Men's 200m Backstroke View View View View 01/07/2009 17:38:46
Women's 50m Freestyle View View View View 01/07/2009 17:57:55
Men's 50m Butterfly View View View View 01/07/2009 18:05:43
Men's 4 x 100m Medley Relay View View View View 01/07/2009 18:34:29
Women's 4 x 100m Freestyle Relay View View View View 01/07/2009 18:44:34
Men's 50m Freestyle View View View View 02/07/2009 17:57:19
Women's 50m Backstroke View View View View 02/07/2009 18:03:44
Women's 4 x 100m Medley Relay View View View View 02/07/2009 18:28:25
Men's 4 x 100m Freestyle Relay View View View View 02/07/2009 18:51:54
Mixed 8 x 50m Freestyle Relay View View View View 02/07/2009 19:14:27
PDF Results for Isle of Wight - Swimming


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Email: stvauthor@yahoo.com
Shannon Vannatter
Inspirational Romance Novelist
Inkslinger Blog
Talks with Authors
Hill Country Cowboys
Texas Cowboy Series
Texas Rodeo Series
Shannon Taylor Vannatter – Story Behind the Story – Part 2 of 3
April 9, 2014 By Shannon Vannatter 9 Comments
Shannon here: Ever wonder where author's get their ideas? Rodeo Song started as a long ago dream inspired by Michael Bolton. Comment on any post dated April 7 -11 to enter the drawing for a copy. Deadline: April 19th, 11:59 pm central time.
Back in Michael Bolton's heydey, I attended one of his concerts. I was in love with his gravely voice and the passion he put into his love songs. The stadium was built with the arena at the bottom and the lobby at the top with a dozen or more doorways into the lobby. My friend, her husband, and I were in the nosebleed seats at the side of the arena.
During the intermission, we noticed a commotion in the lobby. We watched each doorway until we realized Michael Bolton was running around the lobby and a crowd of women were chasing him. He came into the arena and ran to the other end from the stage where he sang Georgia on My Mind on a smaller stage for fans seated at the back of the arena.
That night, I had a dream. You know how dreams are—even though I was married, I wasn't in the dream. In the dream, I was in the lobby. He came running by, grabbed my hand, and took me onstage where he sang Georgia on My Mind. I grew up in Georgia, so it fit.
I thought the dream was funny, so I told my husband and all of my friends, family, and co-workers. Years later, when I started writing, I realized that dream could be the beginning of a great book. I wrote it in 2000. In the book, he had dark hair, was a rock star with a bad reputation, and there was a suspense element with a stalker. To add a twist, the heroine didn't like him and only went to his concert as a favor to a friend. That seemed more interesting to me than if she was just a fan.
The book got around eight rejections. By then, my rejection count had surpassed 200 on seven different books. Though I'd gotten a book published through Print on Demand, I realized that wasn't what I wanted.
In pursuit of a traditional publisher, I joined two writers' groups, attended monthly meetings, and went to every writing conference within driving distance. In the process, I realized suspense wasn't what I wanted to write and turned to straight romance. I eventually found American Christian Fiction Writers, attended their national conferences, joined, and joined a critique group through them.
Nine and a half years later, I got my first contract and my debut novel released in 2010. Four books later, Harlequin took over Heartsong Presents and I got to continue my Texas rodeo series. I was brainstorming ideas and thought, hey I could strip the suspense element and make the rock star a country star.
By then, I knew fiction had to make more sense than real life in order to keep the reader reading. If the reader stops to think—that wouldn't really happen—the author has ruined the reader's enjoyment. I had to figure out why my heroine would go on stage with a country star she didn't even like.
Because they were high school sweethearts. And she still had feelings for him, so she used her friend as a reason to attend his concert when deep-down she wanted to see him again.
My editor liked the concept and my dream came true—in a fictional sort of way. I still write down interesting dreams just in case I need them for a book.
Note: I also had to figure out why my country star looked like a rock star. Midway through the story, he tones down his image and gets a haircut. So that's why he has short hair on the cover, but that's a whole other blog post you can read: http://acfwarkansas.com/when-i-get-stuck-on-a-book-i-get-by-with-a-little-help-from-my-friends/.
About Shannon: Shannon Taylor Vannatter is a stay-at-home mom/pastor's wife/award winning author. She lives in rural central Arkansas in a town with a population of around 100, if you count a few cows. Shannon writes inspirational contemporary romance and it took her nine years to get published in the traditional market.
Shannon hopes to entertain Christian women and plant seeds in the non-believer's heart as her characters struggle with real-life issues. Their journeys, from ordinary lives to extraordinary romance through Christ-centered relationships, demonstrate that love doesn't conquer all—Jesus does. In her spare time, she loves spending time with her family and doing craft projects. Learn more and connect: Website: https://shannontaylorvannatter.com, Facebook: http://facebook.com/shannontaylorvannatter, Goodreads: https://www.goodreads.com/user/show/29672798-shannon-vannatter, Pinterest: http://www.pinterest.com/stvannatter/, Twitter: https://twitter.com/stvauthor
About the book – Rodeo Song (Book 6 in the Texas Rodeo series):
JENNA WENTWORTH FOUND THE MAN OF HER DREAMS
But when silken-voiced Garrett Steele set out for stardom, he left Jenna—and his cowboy past—far behind. A chance encounter at one of his concerts propels him back into Jenna's life. But, once burned by love, Jenna must guard her heart against the captivating singer.
Once upon a time, Garrett vowed he'd be a success, no matter what. But that path shattered his soul. His reunion with Jenna makes him long for things he once took for granted. Now he must show her that he's found what he was looking for all along…right here in his hometown.
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Come back April 11th for an excerpt from Rodeo Song!
Follow my blog tour where I'll be talking more about Rodeo Song and giving away lots of copies:
April 1 – ACFW Arkansas – http://acfwarkansas.com/
April 3 – Ausjenny – http://ausjenny.blogspot.com
April 5 & 6 – Barn Door Book Loft – http://www.barndoorbookloft.net/
April 7, 9, & 11 – Inkslinger Blog – https://shannontaylorvannatter.com/blog/
April 8 – Arkansas Authors – http://arkansasauthors.com/category/interview/
April 10 – Lena Nelson Dooley – http://lenanelsondooley.blogspot.com/
April 10 – Jennifer Slattery – http://jenniferaslatterylivesoutloud.com
April 15 – Cherie Burbach – http://workingwritersandbloggers.com/blog/
April 16 – Deborah Vogts – http://deborahvogts.blogspot.com/
April 17 – Ane Mulligan – http://www.anemulligan.com/
April 21 – Kimberly Rose Johnson – http://kimberlysmusings.wordpress.com/
April 21- Goodreads – Heartsong Presents Q & A –https://www.goodreads.com/group/show/129196-love-inspired-heartsong-presents
May 9 – Kristena Tunstall – http://kristenatunstall.com/blog/
May14 – Ginger Solomon – http://gingersolomon.blogspot.com/
Filed Under: Blog Tagged With: Aubrey TX, Book Giveaway, book giveaways, Contemporary Romance, Cowtown Coliseum, Dallas TX, Fictional Romance, Fort Worth Stockyards, Fort Worth Stockyards Championship Rodeo, Fort Worth TX, Happily Ever After, Happily Ever Afters, Heartsong Presents, Hero & Heroine, Inkslinger, Inspirational Author, Michael Bolton, Rodeo, Rodeo Song, Romance, romantic destinations, Shannon Taylor Vannatter, Story Behind the Story, Texas Rodeo
Shannon Taylor Vannatter – Real Life Romance – part 1 of 3
Shannon Taylor Vannatter – Romantic Excerpt – Part 3 of 3
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Connie R. says
Would love to read!
Brenda Anderson says
I always love hearing this story behind your story. I already ordered Rodeo Song, so don't put me in your drawing. 🙂
angela chesnut says
Sharon Timmer says
Shannon – I want to read this book even more now 🙂
Shannon Taylor Vannatter says
Connie and Angela,
It was a fun dream. I don't dream so vividly anymore and can't remember most of them when I wake up. So it may be my only dream book, but it was fun.
Sharon,
I love his car commercial. It makes me smile every time. No matter what, he puts his all into every song.
Robin Driscoll says
Wow that is an interesting story – I don't ever remember my dreams.
stvannatter says
I don't usually remember dreams, Robin. And they're not usually as vivid as that one. But since I made this one into a book, I keep a notebook near my bed, just in case.
Melanie Backus says
What a neat dream! Writers just amaze me with their writing talents.
melback at cebridge dot net
Hey Melanie,
I haven't had another book worthy dream and that one was a long time ago. But I keep a notebook in my nightstand. Just in case.
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text:
Coffin, Marian Cruger
Marian Cruger Coffin
Please log in or register to edit.
Dates of Birth and Death
September 16, 1876-February 2, 1957
Massachusetts Institute of Technology, 1904
Fellow, American Society of Landscape Architects, 1918
Winterthur Estate, Delaware
William Marshall Bullitt Oxmoor estate, Glenview, Kentucky, 1909
University of Delaware, 1919
Bayberryland estate, Shinnecock Hills, Long Island, New York
Marian Cruger Coffin (1877-1957) was born in Scarborough, New York and known as one of the first American woman pioneers in landscape architecture.
Career in Architecture
Coffin was best known for designing the grounds of Winterthur, the Henry F. du Pont estate and the campus layout for the University of Delaware.
Major Buildings and Projects
Some of Coffin's best known projects include her designs for the grounds of Winterthur, the Henry F. du Pont estate and the campus layout for the University of Delaware. She won the Gold Medal of the Architectural League of New York for her work in 1930. Coffin was highly regarded in the field and perhaps the best known female landscape architect to graduate from MIT. More information about pioneering women in landscape architecture at MIT.
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text:
Q: Removing logic duplication in Java I have a legacy code which does the same work on different classes based on case in a switch statement.
Is it possible to reduce code logic duplication in the switch statement below?
I have 3 classes  Giraffe, Hound and Animal. Both classes Giraffe and Hound extend Animal.
public class Animal {
   int sleepDuration
   int noOfLegs;

public setNoOfLegs(int noOfLegs) {
   this.noOfLegs = noOfLegs;
}
public setSleepDuration(int sleepDuration) {
   this.sleepDuration = sleepDuration
}
public getSleepDuration() {
   return this.sleepDuration;
}
public getNoOfLegs() {
   return this.noOfLegs;
}
}

class Hound extends Animal {
    // some  hound specific variables  and functions here
}

class Giraffe extends Animal{
   // some  giraffe specific variables and functions here
}

public class Jungle {

public someMethod(String caseString)  {
    Animal animal = JacksonMapper.convertBytesToType(animalbyteContent, Animal.class);

    switch (caseString) {
    case "giraffe":
         Giraffe giraffe = JacksonMapper.convertBytesToType(contentInBytes, Giraffe.class);
         giraffe.setSleepDuration(animal.getSleepDuration);
         giraffe.setNoOfLegs(animal.getNoOfLegs);
         break;
    case "hound":
         Hound hound = JacksonMapper.convertBytesToType(contentInBytes, Hound.class);
         hound.setSleepDuration(animal.getSleepDuration);
         hound.setNoOfLegs(animal.getNoOfLegs);
         break;
  default :
         log.error("Hurray!! You discovered a new animal species");
}
}

A: I don't understand why you first cast to Animal in the first place but anyway, the easiest refactor I can recommend is extract to method. setSleepDuration and setSleepDuration are shared so you can create a method that accepts two animals:
   Giraffe giraffe = JacksonMapper.convertBytesToType(contentInBytes, Giraffe.class);

setAnimalFields(giraffe, animal);

where setAnimalFields is
public void setAnimalFields(Animal newAnimal, Animal oldAnimal){
         newAnimal.setSleepDuration(oldAnimal.getSleepDuration);
         newAnimal.setNoOfLegs(oldAnimal.getNoOfLegs);
}

redpajama_set_name: RedPajamaStackExchange


text:
Blog + News
2019 Forum Program
Proving that Net Zero is Possible Anywhere
Written by Kathy Berg, Partner at ZGF Architects.
Photo Credit: Tim Griffith
As the need to combat climate change intensifies, desire for sustainable structures drives architecture toward deep efficiency. Our clients are increasingly interested in exploring net zero energy and the number of realized projects across the industry is growing.
And yet achieving NZE is still complex and difficult to achieve. The technology, systems, materials, and solutions that work for one project do not work seamlessly for another – requiring designers to pursue net zero with a flexible approach.
Chief among the issues that affect the design of a project targeting NZE are climate, user behavior, and jurisdictional constraints. Each project must consider how these factors interrelate to make the building operationally successful and create champions for more NZE buildings to follow.
Designers are tasked with providing occupants with a comfortable interior while minimizing energy use with systems that depend on the outside environment. Passive heating and cooling strategies must adapt to the local climate and HVAC and renewable energy systems must be tailored to optimize performance for that area.
At the Rocky Mountain Institute (RMI) Innovation Center in Basalt, Colorado, designers were challenged to meet the organization's goal: creating the most efficient building within a 100-year structure possible while crafting a beautiful and high-performance workplace. Given its high altitude and location in one of the coldest U.S. climates, this was no small task. Coupled with 40° daily temperature swings and limited winter solar capacity due to the average 86" annual snowfall, standard design process was set aside in favor of an entirely new approach.
Nineteen different envelope studies of orientation, massing and thermal insulation resulted in the elimination of mechanical cooling and central heating systems. Even without traditional HVAC, the building prioritizes occupant comfort through a of passive strategies that provide optimal air speed and radiant surfaces and integrating a high-performance envelope with heat recovery ventilation. Notably, the project exceeds energy projections, generating 146% more energy annually than it used in the first year, and boasting a 99th percentile occupant satisfaction rating in thermal and visual comfort.
At the Conrad N. Hilton Foundation Headquarters, the culture of the staff needed to be transitioned from one of controlling a building to a culture of living "within" a building. This included everything from giving up the "suit and tie culture" in favor of dressing seasonally appropriate, to understanding that the building is healthier due to the 100% utilization of outside air. To ensure the building met its mission over its lifespan, users were asked to adjust their daily routine – including operating windows, wearing a sweater during colder months, and/or shutting off a computer at the end of the day. Even with the building systems operating largely as expected, the building fell short of its net zero energy goal after opening. The major culprit? A decorative fountain in the landscape that was not calculated as part of the project's energy budget.
Jurisdictional Constraints
With each jurisdiction governed by unique regulations, NZE projects present a nuanced set of challenges for designers to navigate.
For the PAE Living Building, the first Living Building in Portland, Oregon, designers needed to be agile in their response to city regulations and forge new pathways for future NZE projects in Portland. While most NZE projects utilize the rooftop for solar panels, the City of Portland requires 60% green roof coverage to reduce storm water runoff, reduce the heat island effect, and create green space habitat within an urban center for wildlife. In order to have enough onsite area to meet Living Building Challenge NZE requirements, the rooftop received a waiver from the city by proving it met the intent of the ecoroof by collecting all storm water in a building cistern for water reuse. Designers proved the full roof coverage of PV panels has no effect on heat island as it absorbs the energy that would otherwise turn to heat. Lastly, the project team provided planting on the building facade and street level to mitigate the loss of green habitat on the roof, additionally purchasing habitat land within the city limits to preserve the land indefinitely.
What it takes to go net zero is dynamic. From climate to user behavior to jurisdictional constraints, each NZE structure presents a set of unique challenges that, when solved, create a pathway. The clearer the pathways become to achieving NZE, the more likely others are to follow.
Net Zero Energy is for Industry, Too
San José Adopts Strongest Building Code Among Large Cities
The Zero Exposure Manifesto: Appeal to Media Savvy Professionals for Climate Action
Fundamentals and New Frontiers in Building Energy Efficiency– More Important Than Ever
A Must Read: Anica Landreneau's Roadmap for Cleaner, Stronger Buildings that Help Solve the Climate Crisis
Approaching Zero Energy: Unleash your building's hidden potential
Pittsburgh Paves the Way for a Zero-Energy City
Copyright 2020 - New Buildings Institute


An orchard survey determined that nymphs of M. caryaefoliae regularly feed on both surfaces of pecan foliage, while other pecan aphids feed predominately on the lower leaf surface. Aphid populations on laboratory pecan seedlings were similarly distributed. Comparison of M. caryaefoliae nymphs reared on each leaf surface found the upper surface offers no fitness advantage. Observations of aphid density found evidence that crowding by heterospecific aphids contributes to M. caryaefoliae movement to the upper surface, while conspecific crowding has no effect. Field observations and experiments on laboratory seedlings found that some aphidophagous lady beetle and lacewing larvae predominately search the lower leaf surface for prey. M. caryaefoliae may settle on the upper leaf surface because it is a habitat with reduced probability of enemy encounters.


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You need to be registered and logged in to fully enjoy Englishtips.After that he was appointed as a chief editor of Daily News.
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At the age of 15, he started working as a junior clerk at one law office.Three years later he became a reporter at the Morning Chronicle.
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Reporting to the Director, Volunteer & Community Engagement, the Community Engagement Manager will plan community events, programs, outreach, and engagement efforts that fulfill the Museum's community engagement strategy. Overview in relationship to the LCE team: The Manager is responsible for a large portfolio of community events within the Learning and Community Engagement division including Open Houses, Cultural Celebrations, Sponsored Free Days, Community Program Openings (Community Arts Initiative, Teen Programs, etc.) and Late Nites. These events range in scope from community group meetings to high-profile, large-scale public events serving over 10,000 people, the position is also responsible for the oversight and streamlining of the Museum's participation in all offsite festivals (including those attended by other departments). Representing the LCE team by working closely with colleagues in Curatorial, Education, Facilities, Protective Services, Communications, Stewardship & Events, and Member and Visitor Services to develop event programming and coordinate all logistics including themes, performances, program content, and outreach. Initiate cross-departmental teams to develop themes around exhibitions and current events to bring together multiple viewpoints. Specifically there is an expectation that this role will: •Support the coordination of volunteer and community engagement to develop and maintain a wide range of relationships with community- and neighborhood-based organizations, with a focus on identifying collaborative opportunities, talent, and reciprocal partnerships for community-related events and programs. Strategize opportunities to engage and increase visitors to the MFA from the city of Boston and beyond – including audience engagement throughout the Commonwealth, nationally, and internationally. •Work closely with colleagues in Curatorial, Education, Facilities, Protective Services, Communications, Stewardship & Events, and Member and Visitor Services to develop event programming and coordinate all logistics including themes, performances, program content, and outreach. •Collaborate with Corporate and Institutional Relations, and Foundation and Government Relations staff to fulfill the needs and expectations of donor and sponsor support of community related events and programs (Open House, Cultural Celebrations, Community Arts Initiative, etc.). Assist in the preparation of donor proposals and provide post-event data and summaries. •Collaborate with the Communications Division (Creative Services, Public Relations, and Marketing departments) on the development and production of all collateral materials for community events and programs including press releases, social media campaigns, onsite programs/signs, promotional flyers, etc. Review and approve all web information regarding such events and programs. •Join with colleagues in Development to maintain relationships with key donors interested, involved or invested in community engagement efforts at the MFA. This includes stewarding event sponsors, program donors, and potential supporters of relevant programs and events. •Assist with staffing the Committee meetings, and play a key role as a member of the internal, cross-departmental Community Engagement Team •Support the coordination of cross-departmental teams to develop themes around exhibitions and current events to pull together multiple viewpoints. •Seek opportunities for income generation by offering the Museum as a destination for local non-profits and community-based organizations to hold events and meetings. Specifically related to event management the following responsibilities include: •Work with local performers and artists to develop and curate programming for events, deepening the museums relationship to the Boston artistic community. Cultivate inroads for repeat engagements with partners, artists and performers – marking the MFA as a leader in supporting the local arts scene that brings a connection between the most urgent issues of our times and the objects of art within the MFA. •Develop and direct all aspects of these events from inception to completion, including budget, theme, invitations, format, timing, audio-visual, set-up and menu – providing the highest level of service and attention throughout. Integrate all operational aspects including food and beverage, sound and light, staging, parking, crowd control, signage and volunteer staffing. Prepare all event proposals and work orders; supervise event set-up and attend events, including those held after Museum hours, evenings and weekends. Trouble-shoot unforeseen issues before and during events in order to provide the best possible experience for attendees. Prepare all internal and external post-event reports, including cross-division recaps, donor and sponsor summaries, and budgets. Assist in the production of complex Museum-wide activities as required. Requirements: Bachelor's degree or equivalent, plus 5-7 years of demonstrated experience in events planning and management; Demonstrated understanding of non-profit, civic and community groups; Exceptional organization skills and a demonstrated ability to handle multiple tasks fluidly; High degree of social sensibility and diplomacy; Leadership skills, as well as a collaborative work-style. Effective with both internal and external audiences; Poise, maturity, flexibility, initiative and ability to work as a team player essential; Highly creative; ability to generate new ideas; Strong skills in trouble-shooting and problem-solving; Excellent interpersonal communication skills; Ability to handle sensitive and confidential material; Ability to succeed in a complex and demanding environment; Ability to work a flexible schedule including evenings, weekends and holidays to the extent required.