text:
Myanmar: bringing about change in a frontier market
On December 13, 2014 February 24, 2015 By saigonsaysIn International Development
Shwedagon – one of Myanmar's famous Pagodas
For some of the world's "frontier" markets, such as in Myanmar (formerly Burma) the risks of accelerated growth are that many of the country's poorest get left behind. Working alongside government and the private sector, the efforts of CARE International in Myanmar are starting to demonstrate that establishing from the outset more inclusive models of engagement with business, in an emerging economy such as Myanmar's, can yield positive outcomes both for society and for doing good business.
Last week, I traveled to Myanmar to see for myself how CARE has been collaborating with one of the world's largest pharmaceutical companies, GSK (GlaxoSmithKline), on an initiative which involves GSK investing back 20% of their consumer healthcare profits – across seven markets in Asia Pacific – into improving community healthcare services for some of the region's most vulnerable citizens.
Whilst there, several of us visited CARE-GSK programmes in Lashio, Northern Myanmar, where we found some inspiring gains have already been made since the joint initiative was established two years ago between our organisations…
To paint the briefest of pictures first, the context within Myanmar is unique. You'd be hard pushed to find a more economically vibrant, politically charged and socially dynamic country in Asia than this one. Surrounded by the region's heavyweight nations, Myanmar is the 2nd largest country in Southeast Asia, home to 50 million citizens, and a hybrid mix of Buddhist, Muslim and Christian followers.
Since sanctions were lifted in 2010, many large corporations have been ready to open up businesses in Myanmar and reach out to Burmese consumers, suppliers and local producers.
Year on year growth for the country is spiking upwards, foreign direct investment is strong, hoardes of tourists are queuing up to visit, and a raft of international government development agencies are scrabbling to determine how to take advantage of the country's popularity, in a way that won't mean its predicted growth leaves the majority of its citizens behind.
As has been the case for so many of Myanmar's neighbouring countries in recent times (and was mentioned on this site in previous posts) accelerated economic growth in emerging market economies can often be exclusively for richer citizens, and leave behind a significant under-served class, cut off from being able to access opportunities that others are afforded.
Myanmar already has one of the highest levels of inequality in the world, and this could very easily widen still more in the future.
So, what of the CARE-GSK collaboration within such a context?
The intervention funded by GSK is targeting expectant mothers and child health. One of the most frequent causes of maternal mortality and neo-natal death is a lack of on hand midwives and, more generally, poor standards of medical services. With GSK's investment alongside CARE, these gaps are being addressed via the training and recruitment of a wave of new Auxiliary Midwives (AMWs) working as volunteers alongside government paid midwives.
The AMWs are selected with the input from Village Development Committees (VDCs) and after their training are able to operate most of the duties that a normal midwife would – before, during and after the birth.
Additionally, in each community, our programme has established a "referral fund", managed by the VDC and used to financially support the healthcare needs of expectant mothers.
What struck us from visiting the Lashio programme was how GSK's investment has not directly targeted their core business (selling pharmaceutical products) but instead focused on improving 'common goods' at the local level – funding training courses and new medical clinics, establishing the referral funds, and even looking at how improved water and sanitation facilities at the local level can be improved.
A typical local household in Lashio, Northern Myanmar
With limited public services reaching these groups, and with ongoing internal conflict and displacements happening in the very same villages, CARE believes engagement with a private business such as GSK is one of the only ways in which to address, over the longer term and at scale, the raft of social access barriers which hold people back from living more empowered day-to-day lives.
The result of this work in Lashio is the creation of truly "frontier" healthcare services, reaching marginalised communities, and leveraging the private sector's interest in the country. What our colleagues there were clear on next was how these outputs must link up with the government health systems, and in doing so catalyse engagement between public, private and NGO stakeholders.
Auxiliary Midwives alongside a government trained midwife (far left) working together in Lashio
We met several AMWs, all under thirty years old and each explaining how the new role they play in their communities is not only one they are proud to have, but one that gives them (as young women predominantly still living with their parents) a higher degree of respect and recognition by their communities – communities which are traditionally led by the male members, and by elders.
"Before I was trained as an AMW I was not seen to have much to offer the community because I am young", explained one AMW we met, "but now people listen to me and accept me as having something to offer."
We heard from the AMWs that culture plays a dominant role in how expectant mothers in their communities perceive what to do, and what not to do, during their pregnancies. For example, during their third trimesters it is not uncommon for mothers-to-be to hardly eat at all – antiquated advice passed down to mothers as simply "what you do". One theory attached to this practice being that it encourages smaller babies and easier births.
What was positive to see on our visit was the rapport and joint working arrangements that AMWs were having with government trained midwives, many of whom seem to have already accepted AMWs as an increasingly important set of co-workers.
Village escort for our tour of a local community
All of such impacts have obvious benefits for local Burmese communities, but what about GSK?
Whilst GSK's return on investment seems on the surface of things to be less obvious, it is clear that (in a competitive market such as the pharmaceutical industry) the more that citizens in places such as Lashio have an improved understanding about nutrition and healthcare issues, then the more informed a market will develop in Myanmar for the types of products GSK manufactures.
There are gains to be had in the long term for companies prepared to financially invest their businesses with social purpose outcomes from the outset, and also in collaboration with civil society and NGO partners. GSK's "20% Reinvestment" initiative has set out to do just this, whilst CARE's commitment is to ensure the resulting programme is delivered a way that is both socially responsible and in demand at the local level in first place.
Returning from Lashio, we met with GSK at their head office in Yangon, and the perspectives shared by their General Manager there, Maung Maung Naing, echoed ours, in terms of how these early interventions created together could start to have a ripple effect in influencing changes in the government's investment in pre and post natal healthcare services in Myanmar.
"Aligning this investment to the government's National Plans for public health services is key", Maung Maung explained. This work represents a step in the right direction to doing just that, whilst advocating in the future to government ministries for more funding and support to the emerging AMW network are other ways of advancing this programme further.
The CARE Myanmar team with their visitors
In a year's time, a new set of global commitments addressing the social and environmental issues of our time will be ratified and universally adopted. These are currently set to be called the Sustainable Development Goals and, more than ever before in our recent history, governments, civil society and the private sector will collaborate together over the next fifteen years to achieve these Goals.
And it is this issue of collaboration between sectors, especially where the private sector is concerned, that CARE has long felt holds the key to success in finally breaking down some of the historic barriers – regulation, access, inequality, market development, human rights, gender equity – to addressing poverty and social injustice.
In a "frontier" country such as Myanmar, perceived to be very much on the rise, there is little question that it will still take enormous effort and time to bring everyone in Myanmar up to an acceptable level of prosperity and empowerment.
However, as the sun came up on our last morning in Lashio, I also had very little to question over the fact that if we don't find ways of engaging some of the world's largest companies into this equation, and co-creating with them more inclusive models of engagement at the local level, then we will continue to fall short in addressing poverty's underlying causes, and in reaching any sort of scale in our efforts to re-balance the status quo.
The opportunity to engage more efficiently and effectively across all sectors may yet unlock the right type of answers, and avoid the risk of seeing yet more "exclusive" and unequal growth taking place in a country which promises so much for its future generations.
Last sunrise, Lashio
community healthcareeconomic growthGSKinclusive businessLashiomidwiferyMyanmarYangon
Tacloban: Exposing "middle-income" country realities
Women's Empowerment in the Hospitality and Tourism sector


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è una serie di light novel scritta da Kyōsuke Kamishiro e illustrata da Takayaki. Kamishiro iniziò a pubblicare la serie amatorialmente sul sito web Kakuyomu l'8 agosto 2017 e caricò l'ultimo capitolo il 24 agosto dello stesso anno. Successivamente la serie fu acquistata da Kadokawa Shoten e venne pubblicata in volumi cartacei sotto l'etichetta Kadokawa Sneaker Bunko dal 1º dicembre 2018.

Un adattamento manga, scritto da Kamishiro e disegnato da Rei Kusakabe, ha iniziato la serializzazione sul sito Niconico dal 26 aprile 2019, mentre un adattamento anime, prodotto da Project No.9, viene trasmesso in Giappone a partire dal 6 luglio fino al 12 settembre 2022.

Trama
Nell'estate del secondo anno di scuola media Yume Ayai si è dichiarata al suo compagno di classe Mizuto Irido, e i due hanno iniziato a frequentarsi. All'inizio i due trascorrono del tempo in coppia, ma a causa di un leggero malinteso, si allontanano e si lasciano dopo il diploma di scuola media. Tuttavia, due settimane dopo, il padre di Mizuto e la madre di Yume si sposano, e Mizuto e Yume diventano fratellastri, con la prospettiva di dover vivere sotto lo stesso tetto. Inoltre anche al liceo finiscono per ritrovarsi nella stessa classe. Per non rovinare il rapporto dei genitori, Mizuto istituiscono delle regole per provare a convivere pacificamente ed evitare di infatuarsi nuovamente uno dell'altra.

Personaggi

Doppiato da: Rina Hidaka
È la protagonista femminile principale e la ex fidanzata di Mizuto Irido. Ama leggere, soprattutto le light novel. In passato, lei era piuttosto introversa e timida, ma si sforza a socializzare e diventare popolare dopo essere entrata nelle scuole superiori. Ha passato un brutto periodo quando era alla scuola media con poca o nessuna conoscenza della moda. Prima di andare al liceo, voleva cambiare e iniziò a cercare riviste di moda. Ha imparato a vestirsi correttamente, a truccarsi e così via. È vestita come una tipica ragazza del liceo con stili diversi, dai vestiti ai jeans.

Doppiata da: Hiro Shimono
È il protagonista maschile principale e l'ex fidanzato di Yume. È un liceale relativamente introverso con una grande intelligenza e ha un interesse per i libri di ogni tipo. Non gli importa cosa pensano gli altri per quanto riguarda il suo aspetto esteriore e indossa solo tutto ciò che gli è comodo. Mizuto è un normale studente delle superiori ma è un po' distante dagli altri. Poiché lui adora leggere qualsiasi genere di libro, i suoi compagni di classe lo hanno etichettato come "topo di biblioteca", termine che lui non odiava affatto. Inoltre, il suo rendimento scolastico complessivo è eccellente e gareggia con sua sorella per il primo posto all'esame di scuola superiore.

Doppiata da: Ikumi Hasegawa
È la migliore amica di Yume e amica d'infanzia di Kogure Kawanami. È molto aggiornata per quanto riguarda il senso della moda. Sa anche come truccarsi, sia che lo applichi sul proprio viso, sia sul viso della sua amica. È anche una persona piena di fiducia e si preoccupa delle persone che la circondano, però si dimostra ossessiva quando inizia a interessarsi e ad amare qualcuno, come Yume.

Doppiato da: Nobuhiko Okamoto
È l'amico d'infanzia di Akatsuki. È un ragazzo frivolo e popolare che si è autoproclamato migliore amico di Mizuto. Ha sempre una personalità allegra e, nonostante lui possa apparire a volte fastidioso, è bravo ad abituarsi all'ambiente circostante senza essere timido e ha un'elevata capacità di regolare le relazioni umane.

Doppiata da: Miyu Tomita
È una compagna di classe di Mizuto e Yume. È una ragazza introversa che ama le light novel. Nonostante i voti generalmente scarsi, è stata in grado di entrare nella stessa scuola superiore, dove fa amicizia soprattutto con Mizuto per i loro hobby condivisi. Infatti da un comune hobby di light novel, si è trovata d'accordo con Mizuto e ha iniziato a passare del tempo con lui in biblioteca dopo la scuola, iniziando anche ad avere una cotta per lui.

Doppiata da: Ai Kayano
È la madre biologica di Yume. Il suo marito precedente era troppo impegnato con il lavoro e non si associava molto alla famiglia, portandola alla decisione di rompere il loro legame. È diventata una madre single che da sola ha cresciuto e sostenuto Yume durante i suoi giorni di scuola media fino a risposarsi con Mineaki Irido prima di entrare al liceo.

Doppiato da: Kazuyuki Okitsu
È il padre biologico di Mizuto e patrigno di Yume.

Media

Light novel
La serie è stata inizialmente pubblicata da Kyōsuke Kamishiro sul sito web per racconti autoprodotti Kakuyomu dall'8 al 24 agosto 2017. In seguito i diritti sono stati acquistati da Kadokawa Shoten, che ne ha iniziato la pubblicazione in volumi cartacei sotto l'etichetta Kadokawa Sneaker Bunko dal 1º dicembre 2018.

Volumi

Manga
Un adattamento manga è scritto dallo stesso Kyōsuke Kamishiro e disegnato da Rei Kusakabe. Ha iniziato la serializzazione sul sito Niconico dal 26 aprile 2019. Fujimi Shobō ne raccoglie i capitoli in volumi tankōbon, pubblicati dal 9 dicembre 2019.

Volumi

Anime
L'anime è stato annunciato il 21 luglio 2021, prodotto da Project No.9 e diretto da Shinsuke Yanagi. La composizione della serie è a cura di Deko Akao, col character design di Katsuyuki Sato. La serie è andata in onda il 6 luglio 2022 sulle emittenti AT-X, Tokyo MX, Nippon Television, Fuji Network System a cadenza settimanale. La sigla d'apertura è , cantata dai DIALOGUE+, mentre la sigla di chiusura è  di Harmoe.

Episodi

Note

Collegamenti esterni
Light novel

Manga

Anime

redpajama_set_name: RedPajamaWikipedia


text:
Camps Help Make Children Resilient
Michael Ungar, PhD
When Jacob arrived at his city's day camp for his third season, the camp director was determined to avoid the problems Jacob was experiencing at school. Now eleven years old, Jacob had grown into a heavy child who spoke in a squeaky pre-pubescent voice. He had been tormented by bullies who thought him effeminate. The other boys in his group occasionally did the same, at least until staff intervened. Jacob's parents weren't his best allies either. A business woman and a university economics professor, neither seemed to have very much time for their son. Eight weeks at camp, five days a week, was supposed to be an experience that would be good for Jacob. His father insisted it was time away from the kids who teased him at school. A gruff good-bye each morning in the parking lot suggested to Jacob's camp director that maybe the little boy dragging his lunch bag into the recreation center would have liked a little more time at home and a few more connections with someone who loved him.
There are many children like Jacob who come to camp with problems that threaten their psychological and social development. Fortunately for most of these vulnerable individuals, a camp experience, whether a wilderness residential experience or an urban day camp, creates the perfect blend of conditions that give children what they need to be more resilient. Jacob may not have wanted to be at camp, but with the right programming, his camp could compensate for what he wasn't getting at home.
Why Camps Make Children Resilient
We've lived with a resilience myth since the concept began to become popular in the 1980s. We naively believe that resilient individuals are those who overcome adversity because of special individual qualities. Studies from fields as diverse as child development, cultural anthropology, epigenetics, and neuropsychology are all proving that resilience depends much more on what others do to shape the world around us than our own rugged individualism. When it comes to resilience, nurture trumps nature. Camps, like good schools and loving families, immunize children against adversity by giving them manageable amounts of stress and the supports they need to learn how to cope effectively and in ways that are adaptive rather than maladaptive (e.g., delinquent) over time.
In fact, a less blaming, more ecological understanding of resilience is showing that resilience happens when our interactions with others make psychological, social, and physical well-being possible. What we call resilience is actually the ability of individuals to navigate their way to the people and experiences they need to do well, which means families, schools, communities, and camps must provide what children need when children ask for help. It's a complex set of interactions. The better a child succeeds at finding the experiences that bolster his well-being, the better he will be able to cope with life stressors.
Seven Experiences Children Need
So which experiences, then, are most likely to make children resilient? The best camps do not provide cookie-cutter solutions to what kids need. Instead, great camps understand that the factors that make children resilient are cumulative. One experience contributes to others, expanding a child's psychosocial resources exponentially. In practice, this means camps need to offer children healthy amounts of some or all of the following seven experiences:
New relationships, not just with peers, but with trusted adults other than children's parents. These new relationships teach children social skills to cope with new situations. A cabin full of awkward kids can give them each a chance to play both leader and follower, depending on the activity they're doing. The adults who kids encounter at camp also offer the chance to learn how to deal with people different than their parents. A counselor that a child doesn't like needn't mean a failed camp experience. Instead, it can present an opportunity for the child to learn how to advocate for what she needs and get along in a tough situation. Just think about how useful a skill like that is: being able to negotiate with an adult on one's own to get what one needs.
A powerful identity that makes children feel confident in front of others provides children with something genuine to like about themselves. A child may not be the best on the ropes course, the fastest swimmer, or the next teen idol when he sings, but chances are that a good camp counselor is going to help a child find something to be proud of that he can do well. The camp experience not only helps the child discover what he can do, it also provides him with an audience that shows appreciation. Identities that fortify a child during times of transition and crisis are those that have been acknowledged by others as positive and powerful.
Camps help children feel in control of their lives. Those experiences of self-efficacy travel home as easily as a special art project or the pine cone they carry in their backpack. Children who experience themselves as competent will be better problem solvers in new situations long after their laundry is cleaned and the smell of the campfire forgotten. The goal here is to encourage a child's sense of internality, their perception that they have some say over their world and that the sources of the problems they encounter are properly attributed to either themselves (when they are to blame) or others (when, in truth, the child is an innocent victim of someone else's mistake). The child who has some say over daily activities at a camp and learns to fix problems when they happen (cleaning up a mess when a group of campers get too rowdy) is the child who will take home with her a view of the world as manageable the next time she encounters trouble.
Camps make sure that all children are treated fairly. The wonderful thing about camp is that every child starts without the baggage they carry from home or school. He or she may be a geek or the child with dyslexia. At camp, both find opportunities to just be kids who are valued for who they are. Of course, for camps to achieve this, they must actively encourage the engagement of those who are more vulnerable or marginalized. The more inclusive activities are of individual campers' cultures, and the more activities show, rather than tell, each camper that they have something to contribute, the more children will feel fairly treated. The goal is to strive not only for equality, with every child treated equally, but also to instill a spirit of equity, in which each child receives that which she needs individually to feel valued.
At camp, children get what they need to develop physically. Ideally, they experience fresh air, exercise, a balance between routine and unstructured time, and all the good food their bodies need. Not that s'mores don't have a place at the campfire, but a good camp is also about helping children find healthy lifestyles. Counselors that care enough to look after a child's physical health, bringing out the child's best by encouraging manageable amounts of challenge, are also conveying to the child a belief in the child's physical capacity to cope. That's important for children's long-term physical development. We now know that early experiences of exposure to risk, and poor health resulting from too little exercise when young, have long-term consequences for the child's healthy development.
Perhaps best of all, camps offer children a chance to feel like they belong. All those goofy chants and team songs, the sense of common purpose, and the attachment to the identity that camps promote go a long way to offering children a sense of being rooted. For children from the most risky environments, it's this sense of belonging to a prosocial set of peers and the institution of the camp itself that is a buffer against future feelings of isolation. It's this isolation that contributes to substance abuse and other problem behaviors.
Finally, camps can offer children a better sense of their culture. Camps are places where children can think about their values and share with others the everyday practices that make them feel a part of their families, communities, or ethnic group. It might be skit night or a special camp program that reflects the values of the community that sponsors the camp; or maybe it's just a chance for children to understand themselves a bit more as they learn about others. Camps give young people both cultural roots and the chance to understand children who have cultures very different than their own.
The Impact of the Seven Experiences on Children
Research on resilience (see the additional resources below) shows that the impact of each of these seven experiences will, first, be greatest for children who face the greatest number of challenges. This is the principal of differential impact. For example, while all children need a secure attachment with an adult, for a child such as Jacob, the impact of a summer spent with a counselor who engages him and helps him feel special is more important than it might be to a child who already has the attention of a caregiver elsewhere in his life.
Second, we know from the research that resilience factors are cumulative. One of these seven experiences will benefit a child for certain, but as the child has one experience, other experiences tend to come along, too. For example, a child who can show her talents at camp will likely be one who feels more in control of her life and that she belongs at her camp. She will know that she has something special to contribute, which brings with it a powerful sense of one's self as someone valued by others.
It's for reasons like these that camps can become places for personal development, especially for children who face the most risks. While it is easy to see how camp can offer a child who self-identifies as lesbian or gay or is from a minority racial group a safe (or at least, safer) place to grow up, even children from contexts in which they are privileged can also find at camp opportunities to learn how to cope better with the risk factors that sometimes accompany privilege.
For example, Veronique was a spoiled fourteen-year-old whose divorced father "dumped" her at camp four weeks of every summer. At least that's how Veronique described it. The camp was sponsored by a religious group to instill values in the campers while letting them have a summer of good fun. Veronique did whatever she could to belittle others' beliefs while breaking as many rules as she could get away with, but, curiously, never enough to be sent home. To make matters worse, almost all the campers came from wealthy families, which meant that, often, Veronique's cabin mates had an upside-down sense of entitlement. Veronique quickly turned them into followers by painting herself as a revolutionary resisting the control of the staff.
Thankfully, Veronique's counselor was a calm young woman with a healthy sense of humor. Beneath the haughty attitudes of her campers, she could see children desperate for some positive attention. The older Veronique became, though, the harder it had become to see the softer side of this emotionally neglected little girl, especially when she preferred to model herself on Hollywood brats with too much fame and no responsibility.
Instead of getting angry with her, Veronique's counselor offered her opportunities to help with the younger children so that she wouldn't feel so much like a kid herself. She engaged Veronique in mature conversations about what Veronique believed and why. She let Veronique tease her and the other staff, as long as Veronique did it respectfully. And she made sure Veronique had one-on-one time with her to show Veronique she really mattered. It wasn't always easy to like the girl, especially as it got closer to the end of her four weeks. It was as if everyone could feel the girl's anxiety about going home. Her counselor promised to write, but that did little to calm Veronique or help her behave.
Structured Interventions
It would take a book to fully describe how camp counselors can work effectively with children like Jacob and Veronique. However, interventions that build resilience generally reflect efforts by staff to structure a camp experience so that children can access all seven of the experiences discussed earlier. Those experiences, of course, must be tailored to the developmental stage of the child and the contextual risk the child faces. For example, based on our understanding of resilience, a child's need for an experience of belonging at camp is going to change depending on the child's age and level of neglect or attachment elsewhere in his life.
Younger children tend to feel a greater connection at home and may not need, nor want, as strong a connection to their camp counselor. Ironically, it is the younger teen, preparing to slowly disengage from her family, who may appreciate the inclusive feeling of belonging at camp. Likewise, the neglected child may find his counselor a rare adult he can trust and cling to him with a death grip, while the child who has suffered more severe and prolonged neglect may so lack the skills to join with others, or be so insecure, that counselors are rejected no matter how caring they appear to be.
It's this complexity that makes giving children these seven experiences challenging. While camps can't provide every camper an entirely individual program, bolstering resilience does require some intentional strategies to tailor programming to a child's needs. It might be just a few hours engaging a shy but artistic child in painting props for the end-of-camp festival, or offering a particularly skilled athlete the chance to do a lake swim that is reserved for only the strongest swimmers. Whatever the plan of intervention, camps offer children the foundation stones for resilience when they match programming to the child's psychosocial needs.
Michael Ungar, PhD, is a professor of social work at Dalhousie University and scientific director of the Resilience Research Centre. He has published over 100 peer-reviewed articles and chapters and eleven books on the topic of resilience and its application to clinical and community work with children and families with complex needs. His latest work includes a book for parents, We Generation: Raising Socially Responsible Kids, a clinical textbook, Counseling in Challenging Contexts, and a novel, The Social Worker. Visit www.michaelungar.com.
Originally published in the September/October 2012 Camping Magazine.
We Are Learning Together: Taking Steps Away from Native Cultural Appropriation
Healthy Staff, Healthy Camps
How to Run a Teen Program at a Summer Camp Wary of Teenagers
Allergies Go Beyond Foods: What to Watch in the Camp Setting

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: Erasing output from ssh Hi I have a simple script for ssh connection to cisco switch and I want to get running configuration of the device. The script is written to use if necessary multiple show commands so I'm using invoke_shell().
To avoid waiting for spacebar to be pressed I've added simple while loop.
    while str(recieve).__contains__('--More--'):
        channel.send(' \n')
        time.sleep(1)
        recieve = channel.recv(10000)
        final += str(recieve.decode("ascii"))

And here is the issue.
If I then printout final it shows full show run command without --More-- but when I write contents of final variable to file it adds this string:  --More--         .
I've tried to look in string with replace('--More--', '') but it didn't find that string.

redpajama_set_name: RedPajamaStackExchange


Sorbus scalaris is a particularly attractive mountain ash with an attractive spreading habit. Leaves are frond-like in appearance which turn an appealing rich-red to purple during autumn. Eye-catching, small red berries are produced.
A small tree, so expect a height of up to 4m after 20 years.


All I know is that this song is catchy as f@#$%. Before this track I had never actually listened to the Arctic Monkeys, but this one's a real gem and I can't get it out of my head.
This song is a metaphor for the general stickiness; how we encounter karmic attachment with that one other soul that makes us want to crawl back… There's probably a decent reason why we had to let this person go, but as Blaise Pascal once said, "the heart has reasons of which reason knows nothing." It makes you wonder why there certain people seem to be stickier than others.
Objectivity holds no place in the heart; even if theoretically you may be better off dating someone else, you find your mind drifting back to thoughts of the one who made your heart bleed. Sometimes you just have to let the rationalizations melt away, trust in the universe and go with your instinct… primal magnetism trumps all, y'all.
"So have you got the guts?
Been wondering if your heart's still open and if so I wanna know what time it shuts.
To love, sometimes you must renounce the comfort zone. It means turning your back on a life of mediocrity; forsaking a numb existence of zombitude and taking the risks necessary to pursue what feels real.
After all, it don't mean a thing if it ain't got that *zing*.
This was written by Sarah Safaie. Posted on Thursday, August 22, 2013, at 4:34 pm. Filed under Music. Tagged Arctic Monkeys, do I wanna know?, EMPT, Sarah Safaie. Bookmark the permalink. Follow comments here with the RSS feed.	Post a comment or leave a trackback.


text:
Le pont sur l'Uvac à Žvale (en serbe cyrillique :  ; en serbe latin : ) est situé à Žvale, dans la municipalité de Sjenica et dans le district de Zlatibor, en Serbie. Il est inscrit sur la liste des monuments culturels protégés de la République de Serbie (identifiant SK 189).

Présentation
Le pont a été construit au , au temps de l'expansion de l'Empire ottoman en l'Europe, et il constituait un passage sur la route impériale Sarajevo-Istanbul.

Le pont était constitué de trois arches qui ressemblaient à celles du pont de Višegrad.

À partir de 1974 a été construite la centrale hydroélectrique Uvac, en même temps que tout un réseau de centrales sur la rivière Lim, donnant ainsi naissance au lac de Sjenica, un lac de barrage. Avant le remplissage, l'Institut pour la protection du patrimoine de Kraljevo a conclu un accord avec la directions des centrales du Lim et des travaux de restauration et de protection du pont ont pu être réalisés.

Aujourd'hui, le pont se trouve au fond du lac, entre 60 et  de profondeur.

Références

Articles connexes
 Liste de ponts de Serbie
 Monuments culturels du district de Zlatibor

Pont en Serbie
Monument culturel protégé en Serbie
Zvale


text:
HomeGuidelinesWhat are 10 examples of alliteration?
What are 10 examples of alliteration?
Alliteration Tongue Twisters
Peter Piper picked a peck of pickled peppers.
A good cook could cook as many cookies as a good cook who could cook cookies.
Black bug bit a big black bear.
Sheep should sleep in a shed.
A big bug bit the little beetle but the little beetle bit the big bug back.
What is guttural alliteration?
Guttural Alliteration. Repetition of' 'g' , 'r' and 'c' sounds. Repetition of 'f' , 'ph' and 'v' sounds.
What are 5 examples of alliteration in Beowulf?
Alliteration Examples in Beowulf:
VIII. 🔒 1. "For fear of a feud were forced to disown him…."
XII. 🔒 1. "came from the moor then Grendel going…"
XX. 🔒 1. "The hell-spirit humbled…"
XXIII. 🔒 1. "Grisly and greedy, that the grim one's dominion…"
XXVIII. 🔒 1. "He bound to the bank then the broad-bosomed vessel…"
What are 2 examples of alliteration in the poem?
Examples of Alliteration in Poetry
ONCE upon a midnight dreary, while I pondered, weak and weary,
Scarce from his mold.
But blessed forms in whistling storms.
And the balls like pulses beat;
The free bird thinks of another breeze.
He was four times a father, this fighter prince:
What are some examples for alliteration?
As a method of linking words for effect, alliteration is also called head rhyme or initial rhyme. For example, "humble house", "potential power play", "picture perfect", "money matters", "rocky road", or "quick question". A familiar example is "Peter Piper picked a peck of pickled peppers".
What are the 2 types of alliteration?
Types of Alliteration
General Alliteration. In general, alliteration refers to the repetition of the initial sounds of a series of words.
Consonance. Consonance refers to the repeated consonant sounds at the beginning, middle or end of a word.
Assonance.
Unvoiced Alliteration.
VIII.? "For fear of a feud were forced to disown him…."
XII.? "came from the moor then Grendel going…"
XX.? "The hell-spirit humbled…"
XXIII.? "Grisly and greedy, that the grim one's dominion…"
XXVIII.? "He bound to the bank then the broad-bosomed vessel…"
What are the examples of alliteration?
Peter Piped Picked a Peck of Pickled Peppers.
Three grey geese in a field grazing. Grey were the geese and green was the grazing.
Betty Botter bought some butter, but she said this butter's bitter; if I put it in my batter, it will make my batter bitter,
I need not your needs, They're needless to me,
What is alliteration and give example?
Alliteration is when two or more words that start with the same sound are used repeatedly in a phrase or a sentence. For example, 'tasty tacos' is considered an alliteration, but 'thirty typist' is not, because 'th' and 'ty' don't sound the same. Alliteration is a type of repetition- a repetition of sounds.
Which is the best example of alliteration in literature?
Alliteration is common in poetry, as well as in literature ranging from from Shakespeare to Stephen King. Below are some examples. This example from lines 5-6 of the Prologue of Romeo and Juliet has two sets of alliteration, one with " f " sounds and one with " l " sounds.
When do you use repeated sounds of alliteration?
The repeated sounds of alliteration do not have to appear in sequential words, one immediately after another. A phrase can still contain alliteration if the repeated sounds are separated by other words. For instance, the example below is alliterative despite the "a" and "of". P eter p icked a p eck of p ickled p eppers.
Why is alliteration used as a mnemonic device?
Due to the repetitive component of alliteration, assonance, and consonance, they are considered phonological mnemonic devices, which help to emphasize concepts and make passages more memorable. Sound-based literary devices can also help to project a tone or mood with repeated sounds in words.
Which is a common factor between alliteration, assonance and consonance?
Repetitive sounds are the common factor between alliteration, assonance and consonance. Alliteration differs from the other two because it refers specifically to the initial consonant sound in words. What are the Benefits of Alliteration, Assonance, & Consonance?
What airport do pilots hate the most?
Is Connemara National Park worth visiting?


The Cow Bream has very distinctive yellow stripes from head to tail, There are about 10 yellow bands all together, If you compare it to the SpineFoot, It also has a lot smaller mouth in comparison to its body, That does not help when we are trying to catch it as you can imagine, Both fish are very strong fighters, You will thing that you have hooked a shark.
hotel, Basically anywhere that there is rocks, there will be both of these fish, So you will need just a pole for these fish, 5 6 7meters, whatever you are most comfortable with.
Now put your pieces of prawn meat on the paper and leave them 10 minutes in the sun to dry a little.
That the work done now, You can bait the area using the bread and ground bait mix mentioned in the Grey Mullet section 1, Now you should be fishing about 5-7 meters from the shore, Over a rocky area and about 2 meters deep, This system will also catch Parrot fish, The Parrot Fish is small, Up to about 15cm, Its brown in colour and has very large scales, and 2 quite big rabbit style teeth. Two warnings, Firstly the spine foot stings as I mentioned, The Cow Bream is a very hard fish to catch, But If you catch one big enough, If you decide to eat it, Then you must not eat the head, I know that most people would not even think about eating the head of anything, But the Cow Bream , Otherwise Known as Sarpa, Sarpa has been reported to contain an LSD type drug, There have only been 2 reports of this happening to anyone in the last 10 years, But beware that it is a possibility if you eat the head. So either don't eat the head or enjoy your trip.


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[Press Release] Cargomatic Rebuilds C-Suite: New Team Designed to Spur Growth & Innovation
Cargomatic Rebuilds C-Suite
New Team Designed to Spur Growth & Innovation
Long Beach, CA – July 18, 2019 – Following a $35 million Series B funding round in late 2018, Cargomatic, Inc. has been busy filling out the C-Suite with a talented and experienced team designed to spur innovation and growth for the local freight-matching marketplace.
"Building a successful company always starts with the foundation, and after our Series B funding last year, my primary focus has been to find the best talent I could and bring them to Cargomatic. With our foundation now in place, we are poised to be a leading provider of local LTL, drayage and white glove services in freight markets throughout the United States and beyond," said Richard Gerstein, the company's chief executive.
First to join the new team was Ed Reginelli as Chief Financial Officer. Ed brings over 25 years of experience, managing all aspects of financial accounting, controls, analysis, operations and reporting in complex corporate environments. Before joining Cargomatic, Ed was Chief Financial Officer and a member of the Board of Directors at RhythmOne plc, a digital advertising technology company.
The second addition to Cargomatic's team was Chris Oliver as Chief Marketing Officer. Chris brings more than 20 years of experience leading large and small businesses into and through tremendous growth phases. Prior to Cargomatic, Chris led growth efforts for several well-known transportation technology brands, including Trucker Path, Zonar, and PrePass.
The third addition was Ann Mao as Chief Legal Officer. Prior to joining Cargomatic, Ann held various senior roles at McKesson Corporation, a global leader in healthcare supply chain management solutions, retail pharmacy, healthcare technology and specialty care.
The next addition to the team was Sunil Sharma as Chief Product & Technology Officer. Sunil's breadth of expertise spans platforms, applications, and online marketplaces. Previously, he held product management leadership positions with industry leaders such as Jasper Technologies (acquired by Cisco), Yahoo!, GT Nexus (acquired by Infor), and Manhattan Associates.
The final new addition to the team is Marc Levin as Chief Commercial Officer. Marc is a strategist and business growth executive with over 25 years of experience in sales, strategy development, and innovation covering end-to-end supply chain and logistics solutions. Prior to Cargomatic, Marc led revenue growth initiatives at XPO (formerly Menlo Worldwide), Ryder SCS and Americold Logistics.
In addition to the many new faces at Cargomatic, two members of the existing team were also appointed to the C-Suite – finalizing the rebuild and positioning the company for continued exponential growth.
Matt Hogan, who has been with Cargomatic since the turnaround began in 2016, has been named Chief of Staff. Prior to his new role, Matt was VP of Account Management & Business Process for Cargomatic, responsible for managing customer growth and retention. Matt brings 20 years of logistics experience to the team, including 15 years at TransCore where he was Director of Account Management.
Steve Jackson, who has also been with Cargomatic since 2016, has been named Chief Administrative Officer. Steve brings over 35 years of domestic and international supply chain experience focused on operational and administrative areas of the businesses. Prior to Cargomatic, Steve held roles at Beaver Paper & Graphic Media, IntelliTrans, and Imerys.
About Cargomatic
Founded by a tech entrepreneur from Silicon Valley and a logistics expert from Los Angeles, Cargomatic understands the challenges of local trucking, and we solve them with our technology. By seamlessly connecting shippers and truckers through our marketplace apps and automating all the necessary "back office" work, we help truckers grow their businesses and shippers track their freight in real time. As a single-source freight matching solution, Cargomatic's mobile and desktop apps provide real-time tracking and full shipment transparency, streamlining the process through which shippers access available truck capacity and trusted, affordable drivers. The diversity and experience of our team, our ideas, and the technologies we build are what give Cargomatic the edge in an industry that still relies heavily on phone calls, email, and even fax machines. Shippers post local freight. Truckers haul it. We do the rest. Cargomatic makes connections happen.
211 E. Ocean Blvd.
www.Cargomatic.com
Chris Oliver
Press@Cargomatic.com
Download .ZIP file with photos, bios, logos and screen grabs of our app in action. Need an image for a team member not included? Please contact us at press@cargomatic.com
Download .ZIP file of hi-res headshots of the Cargomatic executive team members. Need an image for a team member not included? Please contact us at press@cargomatic.com


Director of Finance Roche Molecular Systems Inc., Branchburg, NJ.
Requirements: Bachelor's in Accounting, Business Administration, or related + 2 years experience. Up to 20% domestic & international travel (fully-reimbursed).
Lead all financial aspects related to the manufacturing activities of the "Branchburg Cluster," including Branchburg, New Jersey; Marlborough, Massachusetts, Los Gatos, San Jose and operations in Rotkreuz, Switzerland, encompassing approximately 350 different diagnostics reagents for blood screening, virology, microbiology, genomics, and oncology. Provide guidance, advice, direction and leadership to financial staff. Develop appropriate Key Performance Indicators systems for systematic performance measurement. Evaluate all capital spending and process improvement proposals. Establish and implement internal procedures for control, protection of assets and for certification of financial statements. Ensure financial activities are recorded and reported in accordance with international accounting standards and guidelines. Serve as a Controller for Operations with direct responsibility for all financial activities including operating results, budgets, annual production plan, forecasts, standard manufacturing costs, period costs, net working capital, impairment review, general accounting, cost accounting, and financial analysis. Interpret financial results and assist Senior Management and colleagues in understanding their areas of responsibility. Provide financial senior level direction and advice routinely to the Senior Management. Position requires up to 20% fully-reimbursed domestic and international business travel. Supervise 2 employees, 1 Head of Finance and 1 Sr. Financial Analyst, in performing the duties above.


text:
BritainWorld
By Reuters News Service August 26, 2022 0302
File photo|: REUTERS/Luke MacGregor/File Photo
More than 115,000 workers at Britain's Royal Mail RMG.L began the first of four days of strike action on Friday in a pay dispute which the postal group said was likely to cause significant disruption for customers.
It is the latest in a spate of labour stoppages to hit Britain as workers demand higher wages in the face of a cost-of-living crisis, with energy bills soaring and inflation projected to exceed 13% later this year.
"We are going to fight very hard here to get the pay rise our members deserve," Communication Workers Union General Secretary Dave Ward told Sky News.
Royal Mail says it has offered a 5.5% pay rise for CWU-grade workers, its biggest increase in years.
The union, which said the strike was the biggest industrial action taken by workers this summer in Britain, disputes this and says the company has imposed a 2% pay increase on workers, and offered a further 1.5% subject to changes to terms and conditions.
The centuries-old British postal and delivery service apologised to its customers for the disruption and said it had put in place contingency plans, but could not fully replace the daily duties of its frontline staff.
Royal Mail warned earlier this month that it could post a loss for its business in the United Kingdom in the 2022-23 fiscal year if the strike went ahead. Further walk outs are planned for Aug. 31, Sep. 8 and Sep. 9.
Royal Mail Chief Executive Simon Thompson said the business needed to change its working practices to reflect the fact that it now delivers more parcels than letters and the parcels delivery market is very competitive.
"Royal Mail is a company that society wants to exist… but we need this change so we can turn into a parcels business so we can flourish," Thompson told BBC Radio.
"We want to pay our team more. The more change, the more pay."
13-year-old seriously injured as pick up driven by 15-year-old crashes
Abercrombie cuts sales forecast as Hollister falls out of fashion


text:
Ultra Sierra Nevada
Granada, Andalusia, Spain
14-16 Apr, 2023 (Fri - Sun)
Event size: 1000 - 4999 participants
40 km, 62 km, 97.5 km
14 Apr, 2023 (Fri)
5470 m Elevation gain3900 m Elevation drop
Race size: 250 - 499 participants
Trail Sierra Nevada
Maratón Sierra Nevada
Media Sierra Nevada
16 Apr, 2023 (Sun)
2100 m Elevation gain750 m Elevation drop
Al Andalus Ultimate Trail
Loja, Spain
03 Jul, 2023 (Mon)
NewsResults
Results 2017: Ultra Sierra Nevada
Maratón Sierra Nevada José María Blanco Campaña claimed victory with a time of 04:09:50. He finished 16 minutes 12 seconds ahead of David Mundina Gil. The third place went to Israel Prado Martín – Sierra with a time of 04:26:59 For the women, Ester Alves Alevs got a win, finishing with a time of 05:11:15 , followed by Elena Cambil Medina who finished with a time of 05:15:03. Rounding out the top three was Eva Maria Sanchez Olmedo with a time of 05:50:16. Top 5 Men Top 5 Women Complete results Ultra Sierra Nevada Miguel ÃNgel Heras HernãNdez won the race with a time of 12:23:10. He bested Josã© Esteban Martinez who crossed the finish line 19 minutes 20 seconds behind him. Juan Chacon Resina (12:57:06) made notched third place. In the women's race, Mã©Lanie Rousset took top honors by finishing the race in 15:41:01 . Noelia Camacho Ortega earned runner-up honors with a time of 16:14:46. Rounding out the top three was Sonia Escurola Reula with a time of 16:29:05. Top 5 Men Top 5 Women Complete results Trail Sierra Nevada Juan Pérez Torreglosa grinded past more than 184 runners to win in 06:34:32. Álvaro Velázquez Gutiérrez earned runner-up honors with a time of 06:40:06. Albert Pujol García got the third place in 06:51:25. In the ladies race, Monica Vives Vila claimed victory with a time of 08:08:03 . She bested Irma Lorena Duchi Gomez who crossed the finish line 11 minutes 22 seconds behind her. Sonia Mundina Gil got the third place in 08:53:45. Top 5 Men Top 5 Women Complete results §staticmap(46987,5,800,200)


Virtual EMA has been blessed to have a number of incredible supporters and leaders within our organization. All of our Officers and Directors serve in a volunteer capacity. We are grateful for their service and commitment to the mission and vision of improving community resilience through social and collaborative communications.
Pascal Schuback has worked in the emergency management field for over 18 years. He has been involved in virtual coordination responses including the earthquakes of Haiti, New Zealand, Japan, Hurricane Sandy, Typhoon Yolanda and many large scale forest fires. He is passionate about integrating technology, social media and drones to aid in public safety and disaster response globally.
He volunteers as the Managing Director of Crisis Commons, a global network of volunteers who use creative problem solving and open technologies to help people, agencies and communities in times of crisis. Examples include Virtual Operations Support Teams that support incidents including forest fires; flooding; earthquakes and winter storms globally and a university based global situational awareness tool for travel security.
As a former UK police officer with policing experience in the United States and New Zealand, Caroline brings insight and practical experience working within highly regulated and accountable environments. She has been involved in virtual coordination responses including earthquakes in New Zealand, counter terrorism responses in Australasia, active shooter incidents in the US and many large scale wildfires.
Caroline is based in New Zealand and speaks regularly at national and international emergency management conferences; provides counsel to Australasian government agencies on social media implementation and delivers social media for intelligence gathering and investigative training to the criminal justice sector, and public safety, security and emergency management audiences.
Christopher Tarantino, CMCP, has almost 10 years experience in emergency management & response and has acted in a variety of positions across the public and private sectors, including roles at the volunteer, local, county and federal levels. Chris serves as a Subject Matter Expert/Instructor for the National Disaster Preparedness Training Center, a Digital Communications Specialist for FEMA, Vice-Chair of the International Association of Emergency Management's Emerging Technology Caucus and as a volunteer Firefighter/EMT, HAZMAT Technician and Rescue Specialist with the Monroe County Special Operations Unit in New York.
Chris is a certified Crisis Management Communications Professional and is the CEO of Epicenter Media & Training, a crisis/emergency management consulting and training agency with a focus on technology and information/communications management; he leverages his social media, public information, and emergency management communications expertise to help government and public safety organizations communicate to citizens in times of disaster.
Scott is an NDPTC subject matter expert for social media and disasters and NDPTC course instructor, and a FEMA DCSP Digital Communications Specialist reservist. He is active in the #SMEM (Social Media in Emergency Management) and #VOST (Virtual Operations Support Team) initiatives, is on his local CERT Team and ARES (Amateur Radio Emergency Services) group, and is past president of Oregon VOAD (Voluntary Organizations Active in Disaster).
Scott also serves on the IAEM Emerging Technology Caucus and the Department of Homeland Security's Virtual Social Media Working Group.
Cheryl Bledsoe served for 10 year as a local emergency manager. She now works as a technology manager in the 9-1-1 community although continues to work with the emergency management community on Virtual Operation Support Teams and drafting social media curriculum for educational institutions.
Cheryl has been responsible for implementing local, regional and state social media footprints which have included policy development, website redesign and managing blogs, Facebook Fan page and Twitter communications. She served on the Department of Homeland Security's inaugural Virtual Social Media Working Group for 3 years.
Virtual EMA is a registered public charity with 501(c)(3) status.


So how about I want to cut my hair again! lol.
I feel like the front is too long. Like right behind the bang area is still really hangy instead of stick uppy. I'm trying to wait a bit to see if the feeling passes. Here are some recent picts of how I've been wearing it.
The very first picture above is how my hair looked styled with that and castor oil. It reminds me of a more moisturizing version of IC fantasia's polishing gel. I like it a lot!
I've been maintaining it at night as in this video, and getting about 3 days out of my wash and goes out. I then pull it into a puff until I can co-wash it. Other products I am in the middle of trying out and like include Trader Joes Tea Tree tingle shampoo, the Trader Joes Nourish Spa conditioner and Safi hair care's hairsickle. I am loving all of these products and they have been my summer staples for the past 3 weeks.
I have also tried the Organix Argen oil formula conditioner (found it half off at CVS!) and aside from the smell, which is great, I am not sure I am all that impressed.
Very cute! I don't think the front is too long. I love the length all over.
If it was my call (and of course, it's not), I would leave the hair as is. It is a gorgeous shape and length. I completely understand the urge to cut, though. I feel that way when my hair hits a certain length -- starting about where it is now, collarbone-length stretched.
Just as beautiful as Angela Davis my sister!


text:
Anti-TNF therapy in inflammatory bowel disease
Warning over anaemia drugs risk
Nova Laboratories wins funding from Department of Health & Wellcome Trust
Satavaptan application withdrawn
The innovative hospital pharmacist – imagination, skills and organisation
A new era in the treatment of renal anaemia
Inflammatory bowel disease has been revolutionised by anti-tumour necrosis
factor therapy and therapeutic drug monitoring can optimise and guide future treatment decisions
Niels Vande Casteele PharmD PhD
University of Leuven, Therapeutic and Diagnostic Antibodies, Leuven, Belgium; University of California San Diego, Division of Gastroenterology,
IBD Center, La Jolla, CA, USA
Email: niels.vandecasteele@kuleuven.be
Inflammatory bowel disease (IBD) is a relapsing inflammation of the intestine, characterised by flares and remission phases. A distinction can be made between two forms of IBD: Crohn's disease and ulcerative colitis. Crohn's disease is a transmural disease (affecting different layers of the gastrointestinal wall) and is characterised by discontinuous inflammatory lesions that can appear in the whole gastrointestinal tract from the mouth to the anus. Ulcerative colitis is a mucosal disease (affecting only the mucosal layer of the gastrointestinal wall) and is characterised by continuous inflammatory lesions that appear in the distal part of the gastrointestinal tract.
Patients typically present with abdominal cramps, bloody diarrhoea, urgency and the passage of pus or mucus. The diagnosis is made based on history and physical examination as well as objective findings from endoscopic, radiological, laboratory and histological studies to rule out non-IBD causes of symptoms.
It is commonly believed that in the pathogenesis of IBD, environmental risk factors can induce immunological changes and an onset of the disease in genetically predisposed subjects. The prevalence is highest among Western populations and affects 0.2–0.3% of people. The disease has an early onset, with 25% of IBD patients being diagnosed before the age of 21 years.
Up until now there have been no drugs available to cure IBD, and most of the established and evolving therapies used in the treatment of IBD are also used to treat other chronic inflammatory diseases. This is due to the working mechanism of these anti-inflammatory drugs that interact with downstream targets of an (common) inflammatory cascade.
Historically, a 'step-up' approach is followed where more potent drugs are given to patients with a more active or severe disease state. A distinction can be made between drugs to induce remission over a short period of time and to maintain remission over a long period of time. Corticosteroids are used for inducing remission and can either be administered topically or systemically, depending on the disease severity. Antimetabolite therapy with azathioprine, 6-mercaptopurine or methotrexate and 5-amino salicylic acid (for mild-to-moderate ulcerative colitis) are commonly used for maintenance therapy. Patients that are intolerant to immunosuppressive treatment or who become corticosteroid-dependent or corticosteroid-refractory, can be treated with anti-tumour necrosis factor (anti-TNF) monoclonal antibodies (mAbs), whereas beforehand, surgical resection of the inflamed part of the intestine was often the only option.
Anti-TNF therapy allowed targeting treatment goals such as mucosal healing and deep remission that are hard to achieve with conventional immunosuppressive therapies. Interestingly, a 'top-down' strategy with early combined immunosuppression with azathioprine and the anti-TNF drug infliximab was found to be more effective than the conventional 'step-up' therapy for induction of remission and reduction of corticosteroid use in patients who had been recently diagnosed with Crohn's disease.1 This has been an important finding and confirms previous observations that uncontrolled inflammation drives disease progression.
Anti-TNF mAbs
TNF is an important component of the immune system that protects against infections, but this pro-inflammatory cytokine is expressed abundantly in patients with IBD and other chronic inflammatory diseases, such as rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis. Anti-TNF antibodies bind very specifically to their target and block both soluble and transmembrane TNF. In Europe, infliximab (Remicade®), a chimeric IgG1 κ monoclonal antibody and adalimumab (Humira®), a fully human IgG1 κ monoclonal antibody, are approved for the treatment of moderately to severely active Crohn's disease and ulcerative colitis. Recently, golimumab (Simponi®), a fully human IgG1 κ monoclonal antibody, was approved for the treatment of moderately to severely active ulcerative colitis.
Infliximab is administered intravenously in the hospital whereas adalimumab and golimumab are administered subcutaneously and are therefore often preferred by the patient for practical reasons. All anti-TNF antibodies are dosed according to an induction regimen (loading dose) after which patients who respond to the treatment continue treatment according to a maintenance regimen.
Unfortunately 10–30% patients will not respond to anti-TNF treatment (primary non-response), which is often attributed to patients having a non-TNF-driven disease. Of the patients initially responding to induction therapy, 30–60% will lose clinical benefit during maintenance therapy (secondary loss of response), which is often attributed to suboptimal dosing and/or immunogenicity. Secondary loss of response is managed clinically by decreasing the interval between administrations of drug and/or by increasing the dose. If patients do not have an adequate response to dose escalation, switching to another anti-TNF can be considered.
Immunogenicity is defined as the ability of an antigen to elicit a humoral or cell-mediated immune response. In this case, patients will develop anti-drug antibodies that either block the drug's activity directly or cause a faster clearance of the drug by forming complexes in vivo. All anti-TNF antibodies are immunogenic to a certain extent and, over the years, treatment regimens have been optimised to reduce the risk of immunogenicity: maintenance therapy instead of episodic therapy and treatment with concomitant immunosuppression (such as azathioprine and methotrexate) instead of monotherapy.2,3
The large inter- (primary non-response) and intra- (secondary loss of response) individual variability in response to anti-TNF agents has sparked the interest of physicians and pharmacologists to investigate the exposure–effect relationship of these drugs. This can be done by measuring concentrations of drug and anti-drug antibodies in serum to establish a concentration–time profile that can be linked with biomarker, clinical or endoscopic outcome measures. Different kits or services are offered by academic research institutes and commercial companies to perform therapeutic drug monitoring (TDM), the majority of which are either enzyme-linked immunosorbent assays or radioimmunoassays.
At different time points, a concentration–effect response was shown for all three anti-TNF agents, indicating higher rates of response, remission and even mucosal healing in those patients with higher serum concentrations of drug, as reviewed elsewhere.4 Furthermore, adequate drug trough concentrations early on in the treatment (after induction) were found to be predictive of durable sustained response to the treatment throughout the first year.5
These retrospective studies clearly showed an exposure–effect relationship and led to the hypothesis that TDM in individually treated patients could help to guide treatment regimens and optimise dosing. For example, for the management of secondary loss of response, an algorithm-based approach based on TDM has multiple potential advantages over the empirical approach because it will avoid dose escalation in patients who are unlikely to respond due to either immunogenicity or a non-TNF-driven disease. TDM allows for targeted dose adjustment in patients with low drug concentrations due to non-immunogenic pharmacokinetic mechanisms and it directs patients who likely have a non-TNF-driven disease to alternative treatments more efficiently.
This hypothesis was tested in a randomised, multicentre clinical trial in Denmark, where the investigators randomised 69 Crohn's disease patients with secondary loss of response to maintenance infliximab therapy to either the conventional approach of dose escalation or an approach based on TDM. The co-primary endpoints were the proportion of patients responding to the intervention after 12 weeks in both groups and the accumulated cost related to treatment. Both treatment strategies were found to be equally effective, but interestingly, the approach based on TDM resulted in a 34% decrease in treatment cost compared with the empirical approach of dose escalation.6
In Leuven, Belgium, the first prospective randomised clinical trial was conducted on 263 IBD responsive patients on maintenance infliximab treatment. All patients were first-dose optimised to achieve infliximab trough concentrations of 3–7µg/ml by adapting the interval between infusions (4-, 6-, 8-, 10- or 12-weekly) and dose (5 or 10mg/kg), after which patients were randomised to dosing based on clinical symptoms and C-reactive protein (CRP) or dosing based solely on infliximab trough concentrations. The first part of the study – the optimisation phase – showed that dose escalation based on targeting infliximab trough concentrations within the interval of 3–7µg/ml resulted in a significant increase in the proportion of Crohn's disease patients in remission before and after optimisation (65.1% and 88.4%, respectively; p=0.02) and concomitantly a significant reduction in CRP concentration before and after optimisation (4.3mg/l and 3.2mg/l, respectively; p<0.001). A similar effect was not observed for ulcerative colitis patients, most likely because the majority of patients included in the trial were already in remission and did not have elevated CRP at baseline. The second part of the study – the randomised maintenance phase – did not show an additional effect to continue dosing based on TDM compared with dosing based on symptoms and CRP. However, in the group of patients with dosing based on clinical symptoms, significantly more patients needed an intervention because of loss of response compared with the group of patients with dosing based on infliximab trough concentrations (17.4 and 6.3%, respectively; p<0.01).7
The results of these first randomised clinical trials indicate that TDM can add value to current practice, by optimising the dose of anti-TNF in individual patients or guide treatment decisions at times of insufficient or no response.
Inflectra® and Remsima®, two infliximab biosimilars, have been approved for the treatment of IBD in Europe. Monoclonal antibodies are large complex molecules that cannot be chemically synthesised but instead require a biological production process in living cells. As the final product is defined by this multi-step biological production process, Inflectra® and Remsima® cannot be regarded as exact copies of the originator Remicade®, but should be seen as biosimilar. This issue has been elegantly reviewed elsewhere,8 but it should be borne in mind that substitution of two similar drugs in one patient can result in a different immunogenic profile and pharmacokinetics, which could potentially alter the pharmacodynamics, and therefore should be avoided. It can be hypothesised that most concepts regarding the exposure–efficacy relationship and immunogenicity rate of the originator molecule can be transferable to biosimilars, but this remains to be shown.
mAbs with a different mechanism of action will soon be added to the armamentarium to treat patients with IBD, as the gut-specific lymphocyte blocking drug, vedolizumab, showed promising results for inducing and maintaining remission. Therefore, together with the increasing options to treat IBD patients chronically throughout the majority of their lives, treatments should be chosen carefully and used optimally at the right time in the right patient.
Inflammatory bowel disease (IBD) is a disabling condition with an early onset, requiring lifelong treatment.
Anti-tumour necrosis factor (TNF) therapy revolutionised the treatment of patients with IBD.
Patients treated with anti-TNF agents are at risk of non-response or loss of response.
Uncontrolled inflammation drives disease progression.
Therapeutic drug monitoring of anti-TNF agents can be used to optimise dosing and guide treatment decisions.
D'Haens G et al. Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomised trial. Lancet 2008;371:660–7.
Colombel JF et al. Infliximab, azathioprine, or combination therapy for Crohn's disease. N Engl J Med 2010;362:1383–95.
Feagan BG et al. Methotrexate in combination with infliximab is no more effective than infliximab alone in patients with Crohn's disease. Gastroenterology 2014;146:681–8.e1.
Vande Casteele N et al. Therapeutic drug monitoring in inflammatory bowel disease: current state and future perspectives. Curr Gastroenterol Rep 2014;16:378.
Cornillie F et al. Postinduction serum infliximab trough level and decrease of C-reactive protein level are associated with durable sustained response to infliximab: a retrospective analysis of the ACCENT I trial. Gut 2014;Mar 4. doi: 10.1136/gutjnl-2012-304094. [Epub ahead of print] (accessed 1 September 2014).
Steenholdt C et al. Individualised therapy is more cost-effective than dose intensification in patients with Crohn's disease who lose response to anti-TNF treatment: a randomised, controlled trial. Gut 2014;63:919–27.
Vande Casteele N et al. OP001 Randomised controlled trial of drug level versus clinically based dosing of infliximab maintenance therapy in IBD: Final results of the TAXIT study. United European Gastroenterology 2013;1:A1.
Declerck PJ. Biosimilar monoclonal antibodies: a science-based regulatory challenge. Expert Opin Biol Ther 2013;13:153–6.
EAHP and EBVS joint press release
Boehringer Ingelheim celebrates inauguration of its new "Center of Competence"
EFFECT-HF demonstrates Ferinject® beneficial effect in patients with CHF and iron deficiency
Results of the Annual General Meeting
Nasal spray relieves cancer pain


TuneUp for the Bookwalter Binge Gran Fondo with a relaxed, small-group ride with Brent & Jamie and some of their friends from the pro-peloton. Enjoy a gourmet lunch following the ride.
The TuneUp was created in 2016 because an event called The Binge shouldn't just have just one ride! The TuneUp is a small, intimate ride held the day before the main event that allows participants to stretch their legs on some of the Bookwalter's favorite roads and enjoy a gourmet lunch at one of their favorite restaurants. Jamie and Brent set an easy pace on the ride and put the focus on enjoying the food and fellowship. A few friends from the pro-peloton will join in for this party-paced excursion and lunch munching.
The 2018 TuneUp Ride is presented by Native Kitchen & Social Pub. Casey Watkins and his Native Team will host the gourmet lunch at their location in Swannanoa.
The TuneUp route will be approximately 25 miles and will include a preview of one of the timed sections of the Bookwalter Binge Gran Fondo.
Registration for the TuneUp is limited to just 30 riders. To sign up, follow the Bookwalter Binge Registration link, choose a route for the Binge and then select TuneUp in the Additional Purchases section of the registration process.


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Home » Vietnam records US$5.5 billion of foreign investment in the first 2 months of 2021
Vietnam records US$5.5 billion of foreign investment in the first 2 months of 2021
by Son Bui March 3, 2021
A food vendor walks past the Temple of Literature in Hanoi. (Nhac Nguyen/AFP/Getty Images)
Japan was the largest source of registered capital, followed by Singapore and China.
Foreign investors also spent US$543.1 million buying shares and contributing capital to local firms.
Visit Vietnam Insider's homepage for more stories.
Vietnam attracted around 5.5 billion U.S. dollars of foreign investment in January and February this year, down 15.6 percent against the same period last year, the country's General Statistics Office reported Tuesday.
Specifically, Vietnam licensed 126 new foreign direct investment (FDI) projects with total registered capital of over 3.3 billion U.S. dollars, down 74.8 percent in quantity and 33.9 percent in capital year on year.
Related: How to setup a foreign invested company in Vietnam
Over the two months, foreign investors also spent 543.1 million U.S. dollars buying shares and contributing capital to Vietnamese firms, down 34.4 percent year on year.
"Despite the impact of COVID-19, Vietnam corded positive growth in key areas. According to our data, foreign investors have invested heavily in manufacturing, processing, real estate, and electricity production and distribution." Sophie Dao, Partner of Global Business Services, an investment consulting firm told Vietnam Insider.
According to local media, a total of 2.5 billion U.S. dollars of FDI was disbursed in the period, up 2 percent against the first two months of 2020, said the office, adding that 71.8 percent were for the processing and manufacturing sector, 15.6 percent for the real estate, and 6.1 percent for the electricity, gas, hot water, steam and air conditioner production and distribution.
Related: Vietnam reports impressive export growth last year
So far this year, the foreign-invested sector has earned US$ 38.07 billion from exports, up 34 per cent year-on-year, and making up 76.1 per cent of the nation's total export turnover.
At the same time, it spent US$ 31.6 billion on imports, up 31.2 per cent year-on-year, and accounting for 66.6 per cent of the country's total import value. That resulted in a trade surplus of nearly US$6.5 billion.
Among 46 countries and regions with newly licensed investment projects in Vietnam during the period, Japan was the largest source of registered capital with nearly 1.5 billion U.S. dollars, followed by Singapore with 861.1 million U.S. dollars and China with 374.9 million U.S. dollars, said the office.
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Today, with virtually half the globe's population wired to the web, the ever-increasing connection has actually created international changes in critical thinking as well as positioning, interfering with market after sector, field after market. Seemingly, with each passing day, some new technological tool emerges that revolutionizes our lives, further growing and also installing our dependancy on the web.
And why not? Human beings have constantly enthralled themselves right into one quest after an additional, all with a method to an end of enhancing our lives. Plainly, the eas managed by the internet are rather literally earth-shattering to claim the least. Three years ago, couple of could have ever imagined the present state of our on-demand-everything society, with the capacity to instantly connect and also carry out organisation in real-time, at a rate that usually appears dizzying at the very best of times.
However, with every one of these supposed contemporary benefits to life, where technology's ever-pervading presence has actually boosted also one of the most basic tasks for us such as hailing a trip or getting food or carrying out any kind of type of business promptly and also successfully, lots of are left in the dark. While everyone have actually become self-professed professionals at consuming content and making use of a variety of tools easily readily available to browse and also choose information, we're efficiently drowning in a sea of electronic overload.
The reality? Today, rising above the sound as well as accomplishing any type of semblance of visibility has become a monumental task. While we could prevail at browsing, we stop working at being located. Just how are we meant to obtain notification while swimming in a sea of false information and disinformation? We've ended up being involved in this master gauntlet where one specialist after one more is trying to educate us just how we could get the proverbial word out regarding our companies as well as accomplish exposure to own more leads as well as sales, but most of us still appear to be shed.
It's clear that online marketing is no easy job. And the reason why we have actually landed in this world of "specialist" web marketers who are regularly cheerleading their offers to help us reach exposure and permeate the masses is as a result of the layer of obscurity that's been paid for to us in part thanks to one key player: Google. Google's shrouded formulas that darken 200+ ranking consider an easy and simple interface has dumbfounded services for well over a decade currently.
Google's core formulas as well as its tendency to shroud its data in layers of obscurity is not something brand-new. Nevertheless, it is important to any kind of understanding of advertising and marketing on the internet simply since this presence goes to the heart of whatever else that you do. Forget social networks and various other kinds of advertising for the time being. Seo (SEO) offers up the proverbial secret to near-limitless quantities of website traffic online.
The much better you learn as well as understand SEO as well as the even more strides you take to learn this apparently confusing and intricate self-control, the more probable you'll be to appear organically in search engine result. And also let's face it, natural search is very important to marketing online. Taking into consideration that the majority of people do not have huge advertising and marketing budget plans and do not know the first thing concerning lead magnets, press web pages and sales funnels, showing up noticeable is important to long-lasting success.


Designed specifically for oral and implant surgery, Surgic AP delivers all the power and performance you ever need for these procedures. 210 Watt power and 50 Ncm torque,8 individual programs options together with a wide speed range of 200-40,000 min-1 offers the flexibility and fast response required for a variety of surgical procedures. The compact console is user-friendly, simple to operate and has been specifically designed for the aseptic theatre environment.


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Jan Rytkjær Callesen (født 2. maj 1963) er en dansk politiker, der var medlem af Folketinget for Dansk Folkeparti.

Han blev valgt for Sydjyllands Storkreds ved Folketingsvalget 2015 med 2972 personlige stemmer.

Referencer

Tidligere folketingsmedlemmer fra Dansk Folkeparti


(www.mobiochem.com) at the Autonomous University of Madrid in the field of simulation of biological systems.
-Project: The research of the recruited applicant will focus on the theoretical study of the mode of action of the anticancer Pt(IV)-based compounds, which are employed in chemotherapy treatments. The mechanistic steps that will be investigated include the permeation of the drug through lipid bilayers, hydrolysis, binding to DNA, and interaction with proteins. Moreover, it is very likely that the PhD student participates in other research projects.
-Duration and start date: The candidate should ideally start on September 2019 and will be hired for 3 years.
-Eligibility Criteria: Candidates must have, by the date of appointment (September, 2019), a Bachelor degree (3 years) and a post graduate degree (e.g. MSc) in Chemistry, Physics or a related discipline. Several theoretical methods, such a molecular dynamics, quantum chemistry calculations, QM/MM, and enhanced-sampling techniques (e.g., umbrella sampling), will be employed. Specific knowledge on any of these methods is welcome but not required, and it is less important than a great enthusiasm for theoretical and computational chemistry and for working in an interdisciplinary environment.
-Salary: Gross salary (before applying national income taxes) is 18300 euros/year and includes Spanish Social Security and public healthcare.
-Funding: The Comunidad de Madrid regional government provides funding for this job from the call to attract research talent to work in research groups at the Madrid region (Ref. 2018-T1/BMD-10261). The duration of the contract is conditioned to the positive evaluation of the project in the monitoring phase, as regulated in the article 25 of the call guidelines (BOCAM order 2273/2018).
-Application: Applications must be submitted to Juanjo Nogueira at juan.nogueira(at)uam.es by May 30th 2019.


Prashish More is a mumbai born creative director, illustrator, set designer & an eternal visual artist. A strong believer of minimalism his body of work consists of a wide variety of mediums. From print to 3D, compositing to special effects, fashion films to various digital content platform …….. there is hardly a hat he hasn't worn. His keen sense of aesthetics marrying the old world beauty with modern lines is thoroughly refreshing.
His first break came when he shot at Coco Chanel's private apartment with Gil Balssimon. This set the ball rolling & he has gone on to do many assignments in every corner of the world including Newyork, London, Paris, Istanbul, Singapore, Malaysia, Maldives, Mauritius, Thailand, Cappadocia, Pomoclay to name a few. He believes in discovering new & in-vogue talent to push the envelope of his creative pursuits.
• Created world-class, beautiful layouts and visuals that supported and reinforced the vision and business objectives of digital content for Nnnow.com; USPA India, GAP India, Aeropostale, Ed hardy, Sephora, Flying Machine, The children's Place, Gant india, nautical India, Arrow, True Blue. Partnered with Arvind's fashion business and marketing teams to ensure that designs meet brand and business objectives.
• Follow market trends and apply an understanding of the apparel marketplace to make decisions that will maximize the effectiveness of creative; keep abreast of trends and directions in the promotion and creative that will keep AIL on the leading edge.
• Created Fashion videos for leading magazines (Elle, Harper's Bazaar, Grazia) & various leading designer brands (Camessi, Desi belle, Form, Shuffle, Prym, The Arvind store, Satya Paul, Primate); which were directed by me.
• Responsible for the overall look and feel of the website and Instagram grid to entice the audience and create the mass following.
• Understanding and responding to promotion performance data, steering the strategy of future creative directions.
• Leading & supervising digital team along with the Visual design for the entire Nnnow.com site.
• Art directed more than 250 photoshoots..
• Articulate cutting edge Art Direction concept boards for Model and product photography.
• Have executed many assignments in every corner of the world.
• Designed and illustrated sets for Ad Campaigns for Satya paul, Fab india, D'decor, Arvind Store, Primante, Camessi, Raheja Properties, Amazon Jewellery, Jaguar Fittings and Editorial shoot concepts for ELLE, Harper bazaar, Grazia, Hello, Dior, Channel.
• Provided Creative Art direction to photographers and stylists on sets of photoshoots.
• Develop budgets and timelines, allocating appropriate resources to projects.
• Done production design for Digital Content shoot for USPA, Flying Machine, ED hardy, TrueBlue, Arvind Store.
• Overseeing retouching process with retouchers and also done the 3D compositing in creatives.
• Art-Direction done for Editorial shoots with ELLE, Harper's Bazaar, Grazia, Hello.
• Done editorial beauty styling for ELLE, Harper's bazaar magazines.
• Working commercially with beauty brands like Lakme, Chambor, Studiowest (Tata Westside in-house beauty brand), Axe perfume, Fair & lovely.
• Worked on 180+ ELLE India issues. Lead the Art team for almost 14 yrs.
• Designed for New launch Point of sale collateral (lbooklets, lookbook, brochures,) for leading indian designers like Vikram fadanis, Ashish Soni, Desibelle, brands Patine, Creyate, FCUK, LO'real Professional, • Designed calendars for Kingfisher, Raheja, Jaguar etc.
• Partner with Visual Merchandising/Marketing on Image selection for all in-store Visual needs • Design Events Visuals and sets. ELLE beauty awards, ELLE Carnival.
• Gold medalist in illustration work on commercial campaign with Designer, Luxury brands and with leading fashion magazines.
• Knowledge in Photography, Videography, Web design and Animation.
• Highly driven, energetic, passionate, flexible, Team player.
• Develops budgets and timelines, allocating appropriate resources to projects. A strong believer in "digital content production is the optimisation of quality x quantity = value".
• Establish and maintain a business rhythm by conducting reviews and meetings on a regular basis.
• Hire, manage and mentor an effective team of graphic designers, production managers and stylists.
• One Voice One team - work philosophy.


Dental implants are an artificial root inserted in the jaw bone. They are a replacement for the root/roots of a missing tooth.
Implants and their attached crowns closely mimic the look and function of a real tooth. Dental implants are made of Titanium, which is lightweight, strong and compatible with the bone.
Along with replacing lost teeth, implants help maintain the shape & density of the jaw bone. They help you eat, chew, smile, talk and look completely natural.
1. Surgical: This is the placement of the implant into your jawbone. We strongly feel that this part of the process should only be in the hands of a specialist, Oral Maxilofacial Surgeon or a Periodontist to ensure optimum outcomes. Your dentist at Hampton Beach Dentists works closely with the specialist, for whom we organise referral.
2. Restorative: This is the placement of restorations/crowns on top of the implant. Your dentist at Hampton Beach Dentists will insert or attach the restorative aspect of the implant (crown's) and assess your dental health. An implant should ideally be placed in a disease free mouth to ensure the implant ongoing success.
The whole process takes anywhere between 3 to 9 months. Only highest level implant components with a warranty are used and all the restorations/crowns are made in Australian laboratories.


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Why CIOs Should Look to Startups
Red Robin CIO Chris Laping meets with venture capitalists to seek out his next source of cloud-enabled competitive advantage.
By Stephanie Overby
Contributing writer, CIO	 May 27, 2014 8:00 am PDT
There are two types of people at a startup technology vendor — the promise-makers and the promise-keepers.
Chris Laping has little appetite for the cold-calling salespeople who fall into the first category. Yet as senior vice president of business transformation and CIO for Red Robin Gourmet Burgers, he's hungry for the next source of advantage in a hyper-competitive industry — whether it's a menu change, a new market or an emerging technology.
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When Laping got the opportunity to meet with well-known venture capital firms and the CEOs of their portfolio companies — the promise-keepers — he leapt at it. "As a CIO, I want to pull back the curtain and understand what innovations they can bring to our business," he says.
Last summer, Laping flew to Silicon Valley for one of Trace3's venture capital CIO briefings, meeting with firms Andreessen Horowitz and Greylock Partners. Having shared Red Robin's business needs with the firms' partners, Laping met with seven or eight companies for 30 minutes each. It was like speed dating, he says, but with startups.
"If it's a bust, at least you haven't wasted much time." Those conversations were "more real, more tangible and more valuable," he says, because he was talking to company leaders, not lackeys.
Finding cutting-edge technology with true business value can be hard for CIOs, says David Chappell, principal of consultancy Chappell and Associates. But the rewards of tapping into early innovation can be great, he says. "To do this successfully, though, the CIO probably needs a direct relationship with the startup CEO. There's enough risk in betting on brand new ideas that you don't want to be communicating through intermediaries."
Laping was so intrigued by the customer-facing products and services he saw at Andreessen Horowitz that he brought his CEO back a few weeks later. (Greylock showcased some interesting IT infrastructure companies, but customer applications provide more chance for transformation, Laping says.)
Among the companies Laping liked were visual marketing firm Pixlee, which aggregates images and videos uploaded by customers; video interviewing platform HireVue; and analytics startup Quantifind. That they're all cloud-based is no coincidence.
"If you're innovating today, it's going to happen in the cloud," Laping says. "You're able to turn on a lot of cool stuff a lot faster without onboarding a lot of new IT talent."
While Red Robin hasn't signed any big deals with the startups Laping spoke to, the company is testing them all this year. HireVue is appealing because, with high turnover and growth, Red Robin is in "constant hiring mode," he says. The cloud-based video interviewing tool could save managers time. Pixlee, he says, is like a corporate version of Instagram, letting Red Robin curate customer photos of its restaurants and products.
Laping would like to make the VC meetings a regular occurrence. The opportunity is not just to purchase a product before everyone else, but to influence its development, he says. "These conversations quickly go from, 'What is this thing?' to 'Wouldn't it be cool if it could…'" he says. "That's what's so compelling."
Stephanie Overby is regular contributor to CIO.com's IT Outsourcing section. Follow everything from CIO.com on Twitter @CIOonline, Facebook, Google + and LinkedIn.
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Stephanie Overby is a regular contributor to CIO.com.