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Correction to: Association between inflammation and systolic blood pressure in RA compared to patients without RA
Zhi Yu1,2,
Seoyoung C. Kim3,4,
Kathleen Vanni3,
Jie Huang3,
Rishi Desai4,
Shawn N. Murphy5,6,7,
Daniel H. Solomon3,4 &
Katherine P. Liao3,7
The original article was published in Arthritis Research & Therapy 2018 20:107
Correction to: Arthritis Res Ther
Following publication of the original article [1], it has come to our attention that we did not appropriately convert the units for CRP from the National Health and Nutrition Examination Survey (NHANES) from mg/dL to mg/L. In this study, NHANES was considered the general population cohort for this study; interestingly, the correction resulted in changes to a broader range of CRP values in NHANES from 0.01 to 18.0 mg/dL to 0.10 to 180.0 mg/L.
The overall results did not change the message for this study. We continued to observe a general positive association between CRP and blood pressure (BP) in all three groups, RA, non-RA and NHANES. For RA and non-RA this relationship held until a CRP level of approximately 7 mg/L when an inverse association was observed between CRP and systolic BP. In NHANES, we also observed a similar association of higher CRP associated with SBP until approximately 7 mg/L when the there is no association between CRP and SBP. In NHANES, 15% have a CRP above 7 mg/L compared to 32% in the RA and 21% non-RA cohorts. Thus, with the smaller percentage of subjects with a CRP above 7 mg/L in NHANES, there was potentially less power to detect an association.
Line-by-line corrections of our results are given below:
Results, page 3, last sentence in the right column should read: "…in the non-RA outpatient population, and 1.80 mg/L (range 0.10 to 180.10 mg/L)."
Results, page 4, 2nd paragraph, first sentence. The range of CRP was "0.10-180.10 mg/L in NHANES."
Results, page 4, 3rd paragraph. "In comparison, within NHANES, we generally observed a positive association between CRP and SBP also until 7mg/dL when there is no association between CRP and SBP."
Results, page 4, 2nd column, last sentence of the second paragraph, "Findings from the sensitivity analysis showed a general linear association between CRP and SBP in NHANES after trimming of the CRP outliers; this finding is consistent with previous studies in the general population. For RA and non-RA where higher levels are typically observed, the relationships were similar to the main analyses."
In Table 1, the median (IQR) of CRP in NHANES should be 1.80 (0.70, 4.30) mg/L.
Figure 1 The relationship between C-reactive protein levels (CRP) and systolic blood pressure with 95% confidence intervals, in the rheumatoid arthritis (RA) outpatient population and the general population (National Health and Nutrition Examination Survey (NHANES)). RA outpatient population CRP range 0.20–126.90 mg/L; NHANES CRP range 0.10–180.10 mg/L (attached)
Figure 2 The relationship between C-reactive protein (CRP) levels and systolic blood pressure with 95% confidence intervals, in the non-rheumatoid arthritis (RA) outpatient population and the general population (National Health and Nutrition Examination Survey (NHANES)). Non-RA outpatient population CRP range 0.10–416.20 mg/L; NHANES 0.10–180.10 mg/L (attached)
We have also updated the supplementary figures to reflect the updated data:
The relationship between C-reactive protein levels (CRP) and systolic blood pressure with 95% confidence intervals, in the rheumatoid arthritis (RA) outpatient population and the general population (National Health and Nutrition Examination Survey (NHANES)). RA outpatient population CRP range 0.20–126.90 mg/L; NHANES CRP range 0.10–180.10 mg/L
The relationship between C-reactive protein (CRP) levels and systolic blood pressure with 95% confidence intervals, in the non-rheumatoid arthritis (non-RA) outpatient population and the general population (National Health and Nutrition Examination Survey (NHANES)). Non-RA outpatient population CRP range 0.10–416.20mg/L; NHANES 0.10–180.10 mg/L
Yu Z, et al. Association between inflammation and systolic blood pressure in RA compared to patients without RA. Arthritis Res Ther. 2018;20:107 https://doi.org/10.1186/s13075-018-1597-9.
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Zhi Yu
Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Division of Rheumatology, Allergy and Immunology, Brigham and Women's Hospital, Boston, MA, 02115, USA
Seoyoung C. Kim, Kathleen Vanni, Jie Huang, Daniel H. Solomon & Katherine P. Liao
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, MA, USA
Seoyoung C. Kim, Rishi Desai & Daniel H. Solomon
Research Computing, Partners HealthCare, Charlestown, MA, USA
Shawn N. Murphy
Laboratory of Computer Science, Massachusetts General Hospital, Boston, MA, USA
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
Shawn N. Murphy & Katherine P. Liao
Seoyoung C. Kim
Kathleen Vanni
Rishi Desai
Daniel H. Solomon
Katherine P. Liao
Correspondence to Katherine P. Liao.
Figure S1. The relationship between C-reactive protein levels (CRP) and diastolic blood pressure (A), pulse pressure (B), and mean arterial pressure (C) with 95% confidence intervals, in the RA outpatient population and general population (NHANES). RA, rheumatoid arthritis; NHANES, National Health and Nutrition Examination Survey. (PDF 108 kb)
Figure S2. The relationship between C-reactive protein levels (CRP) and diastolic blood pressure (A), pulse pressure (B), and mean arterial pressure (C) with 95% confidence intervals, in the non-RA outpatient population and the general population (NHANES). RA, rheumatoid arthritis; NHANES, National Health and Nutrition Examination Survey. (PDF 111 kb)
Figure S3. The relationship between C-reactive protein levels (CRP) and systolic blood pressure with 95% confidence intervals, in the RA outpatient population and the general population (NHANES) with trimming of extreme measurements of CRP (< 0.5% and > 99.5%). RA outpatient population CRP range 0.20–92.40 mg/L; NHANES CRP range 0.20–42.20 mg/L. RA, rheumatoid arthritis; NHANES, National Health and Nutrition Examination Survey. (PDF 12 kb)
Figure S4. The relationship between C-reactive protein levels (CRP) and systolic blood pressure with 95% confidence intervals, in the non-RA outpatient population and general population (NHANES) with trimming of extreme measurements of CRP (< 0.5% and > 99.5%). Non-RA outpatient population CRP range 0.10–142.20 mg/L; NHANES CRP range 0.20–42.20 mg/L. RA, rheumatoid arthritis; NHANES, National Health and Nutrition Examination Survey. (PDF 13 kb)
Yu, Z., Kim, S.C., Vanni, K. et al. Correction to: Association between inflammation and systolic blood pressure in RA compared to patients without RA. Arthritis Res Ther 21, 170 (2019). https://doi.org/10.1186/s13075-019-1940-9


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Home / ENTERTAINMENT / Movies & Showtimes / What We're Watching: 'Don't Look Up' Tops Netflix Movie Viewership For Third Consecutive Week
What We're Watching: 'Don't Look Up' Tops Netflix Movie Viewership For Third Consecutive Week
By STEVEN HERBERT, City News Service
"Don't Look Up" was the most-watched English- language film on Netflix for the third consecutive week despite a 61.8% drop in viewership from the previous week, according to figures released Tuesday by the streaming service.
Viewers spent 58.2 million hours between Jan. 3 and Sunday watching the comedy about an approaching comet that will destroy Earth in its second full week of release.
"Don't Look Up" was watched for 152.29 million hours the previous week and for 321.52 million hours in the first 17 days it has been available.
"Mother/Android" was second with 29.73 million hours watched. The post-apocalyptic science fiction thriller among four films in the latest top 10 not in the previous week's.
The 2011 Adam Sandler-starring romantic comedy "Just Go With It" returned to the top 10 after an eight-week absence, placing seventh with 10.53 million hours watched.
Another Sandler film, "The Longest Yard," which was released in 2005, made its debut in the top 10, finishing 10th with 9.96 million hours watched.
The 2021 South African computer-animated action comedy "Seal Team" was ninth with 10.31 million hours watched the first full week it was available on Netflix.
Dropping out of the top 10 were two Spider-Man films, "Spider-Man," released in 2002 and 2017's "Spider-Man: Homecoming," the documentary-style year in review comedy "Death to 2021" and the 2019 action comedy "Fast & Furious Presents: Hobbs & Shaw."
"Red Notice" dropped one spot to sixth with 14.54 million hours watched, 23.7% less than the 14.54 million hours watched the previous week. The action comedy has been watched for a record 422.69 million hours in its 59 days of release.
The fourth season of "Cobra Kai" topped the English-language television programs for the second consecutive week with 107.81 million hours watched of its 10 episodes, 10.2% less than 120.06 million hours the previous week when it was available for three days.
The eight-episode limited series "Stay Close" rose three spots to second with 91.18 million hours watched in the first full week of the thriller's release, 191.4% more than the 31.29 million hours watched the previous week when it was available for three days.
All four seasons of "Cobra Kai" made the top 10, with the third and second seasons of the sequel to the 1984 film "The Karate Kid" making the top 10 for the first time, joining the first season, which also made the previous week's top 10.
The third season was ninth for the week with 20.1 million hours watched while the second season was 10th with 19.34 million hours watched. All four seasons consist of 10 episodes each.
The other program in the top 10 not in the previous week's was the first season of `Manifest, with the canceled NBC supernatural drama returning after a 17-week absence, placing fifth with 30.16 million hours watched of its 16 episodes.
Dropping out of the top 10 were the three-part documentary series "Crime Scene: The Times Square Killer"; the 10-episode military documentary "WWII in Color: Road to Victory"; and the first season of "Emily in Paris."
The 10 most-watched English-language movies on Netflix were "Don't Look Up"; "Mother/Android"; "The Lost Daughter"; "Back to the Outback"; "The Unforgivable"; "Red Notice"; "Just Go With It"; "Journey 2: The Mysterious Island"; "Seal Team"; and "The Longest Yard."
The 10 most-watched English-language television programs on Netflix were the fourth season of "Cobra Kai"; the limited series "Stay Close"; the second season of "The Witcher"; the second season of "Emily in Paris"; the first season of "Manifest"; the first season of "The Witcher," the first season of "Cobra Kai"; the sixth season of "Queer Eye"; and the third and second seasons of "Cobra Kai."
What We're Watching: Spider-Man: No Way Home' Still Tops at Box Office With $33 Million
U.S. Movie Theaters Closed Over Coronavirus; Pasadena's Arclight, Ipic, Laemmle All Go Dark
Viral Videos: Movies To Watch While on Lockdown
Published on Apr 2, 2020

redpajama_set_name: RedPajamaCommonCrawl


Ever since I was a child, I've been fond of woodworking. I would watch my father and my great uncle create things seemingly out of nothing. My first large solo project was in 2010 when I needed a bathroom vanity and couldn't find exactly what I was looking for. So I decided to build one. With basic tools and knowledge gleaned from years of watching the New Yankee Workshop, I constructed an 8 foot long double sink vanity out of solid maple. I was bitten by the bug. Since then I have spent countless hours in my garage working on improving my skills. Multiple custom Big Green Egg tables initially rolled out of the shop, followed by a number of dining tables, desks, jewelry cases and other custom projects. I also make a number of yard games including yard dice for Yardzee and Farkle, tumbling blocks reminiscent of Jenga and Kubb, an old Scandanavian lawn game, all typically in stock in my Etsy shop.
Contact me for any custom order requests.


Back to: Books, Tracts, etc.
This book invites you to go on an incredible journey with the Creator of the Universe. Sue Carlisle, the author, takes you on an expedition through the first three chapters of Genesis.
What if the Bible is true? What if Jesus is Creator, like the Bible says He is? What if the One who spun the galaxies, perfumed the flowers, flavored chocolate and formed every living thing really did die on a cross for us?
If Jesus is who He says He is, then we have a God whose imagination, artistic flair, sense of humor, and capacity to love is far beyond our imagination.
Did you know that the Creator really is inviting us to walk with Him, get to know Him and learn to love Him and the world that He loves? God really is offering us a place in His Father's Kingdom, an eternal kingdom that surpasses anything we've ever imagined.
How can we know for sure? He revealed it all "in the beginning."
This is your invitation to join Sue Carlisle on this expedition through nine lessons taken from seeing God's amazing character as described in the first three chapters of Genesis. These lessons are God's response to her broken question of "How do I go on?" He replied, "Look at Who I am."


Volvo Turkey and Arkas Otomotiv organized a great summer party last week, at a great place; The Swedish Palace. The Consul General of Sweden; Mr.Torkel Stiernlöf and the President of Volvo Car Turkey Torben Eckardt welcomed the guests and made speeches about Volvo cars and Swedish culture. Volvo S80, S60 and XC60 were also on display in the gardens of Swedish Consulate.
Volvo Türkiye ve Arkas Otomotiv, geçen hafta İsveç Sarayı'nda bir yaz kutlaması düzenledi. İsveç Konsolosu Torkel Stiernlöf ve Volvo Car Türkiye Başkanı Torben Eckardt'ın ev sahipliği yaptığı bu güzel etkinlikte, canlı müzik, lezzetli yemekler ve İsveç Konsolosluğu'nun harika bahçesinin tadını çıkarttık. Ayrıca Volvo S60, S80 ve XC60 modellerini de inceleme fırsatı bulduk.
These H&M shorts have the best cut and I have it almost in every color. This color is my favorite for the weekends. Here is my look from Sunday.
This new Chanel nail polish is one of my favorite this season and since we are in June, I wanted to do a "June" giveaway before the month ends.
This week, I was invited to the perfume boutique La Déesse. They carry niche perfume brands and also they have a workshop area where you can create your very own perfume. That day, Lynn Harris, the owner of Miller Harris was present there as well and we had a nice chat about London and perfumes.
Bu hafta La Déesse ismindeki parfüm butiğine davetliydim. Bu mağazada niş parfümleri bulabileceğiniz gibi aynı zamanda workshop bölümünde kendi parfümünüzü yaratabilirsiniz. O günkü etkinlikte Miller Harris markasının yaratıcısı Lynn Harris ile sohbet etme imkanı bulup tüm kokuları yakından inceleme fırsatı buldum.
On Tuesday, I had many appointments like the fitting of my wedding gown, an important meeting and some events that I should attend as a blogger, which I will share soon. That day, the weather was around 32 C degrees in Istanbul, that's why I decided to wear something light that will keep me warm. This orange skirt has been with me for 2 years and it became like a joker item for me in summers. I combined it with white sandals, my Kenneth Jay Lane bracelet, Dior earrings and Chanel handbag. I hope you like it. / Salı günü katılmam gereken birçok toplantı ve lansman vardı, hava da oldukça sıcak - 32 derece civarı - olduğu için yazları joker kıyafetim olan turuncu eteğimi beyaz sandalet, Kenneth Jay Lane bileziğim, Dior küpelerim ve Chanel çantamla kombinledim.


Gone are the days when TV networks got facilities with multiple studios and real set designs. With an ongoing optimization, shrinking resources and unavailability of such vast locations in city centers, the concept of multiple studios is also vanishing from the industry.
Now, the same set is used to record and broadcast more than one program by changing the background, all thanks to Chroma key. The technological progression has definitely helped many TV channels to run their transmissions within constrained resources.
However, many times networks fail to make the most of this technological facility. They certainly can carry out the transmission from the same set all day long. However, it doesn't necessarily translate into good visual experience for the audience. A poor transmission quality eventually results in losing the ratings. And we all are aware of the financial repercussions of withering TV ratings.
The primary reason why TV transmission looks poor on Chroma key is the lack of homework on the virtual set design. It must be kept in mind that a Chroma key doesn't automatically create the virtual experience for the audience. One has to extensively work on the virtual set design to make the most of Chroma key. For that matter, TV channels must invest in 3D designing to enhance the quality of their programs relaying from Chroma sets. Let's see how 3D designing can save the day for TV transmission.
Filling Chroma screen with colors, patterns, and text just for bare minimum presentation is never a good idea. Such virtual set designs—if they are qualified enough to be called design—only look despicable and tacky. These unwanted features of the design will overshadow the televised content. No matter how good is the program, you can't attract good audience numbers if it is shot against a poor background.
By applying 3D designing, TV channels can get rid of this tastelessness. The professional 3D designing work will allow the channels to have realistic virtual set designs without an excess of anything. For instance, seasoned 3D artists can create a whole virtual newsroom that looks closest to the reality.
We are not aware of this, but our eyes always look and discern all the three coordinates or dimensions simultaneously. 3D designing takes care of this aspect. So, a Chroma Key based on 3D design will create a better perception for the viewers that they are seeing an actual space. Moreover, the detail that goes into 3D designing also strengthens this perception. To understand that how much detail is used to work out a 3D design consider this, a good artist even creates a minor shadow of the button present on the electric switch panel.
So, in short, 3D designing can be effectively used in the TV transmission to compensate for the actual studio. For professional 3D designing and animation work, get in touch with XYY Creative Studio. The company provides first-rate 3D rendering and animation services.


May 5, 2009 - One of the main reasons to purchase real estate in Costa Rica is for the fun and relaxing atmosphere that defines the Costa Rica lifestyle. And one doesn't need to go to the beach to take it all in! In the capital city of San Jose and the surrounding areas, there are tons of great places and restaurants to relax or have fun with friends.
As an American, I was a bit apprehensive at first about what to expect. Not speaking fluent Spanish, I didn't know the first thing about the Costa Rica nightlife or where the hot spots were. Luckily, most cab drivers do speak English, and are more than willing to offer suggestions for any occasion.
Within a few weeks, I was able to experience a wide variety of local restaurants and clubs. One of the best things about Costa Rica is the weather, and because it's predictably perfect, there are many outdoor patios available for dining. In fact, I made it a weekly occurrence to enjoy a few hours reading a book and enjoying a bottle of wine on a weekend afternoon at different outdoor eateries. The Costa Rica cost of living is so low that you could realistically spend no more than $10 for lunch, wine and a few hours of relaxation.
If clubbing or night life is your thing, than Costa Rica is the perfect place to live. Most clubs won't shut their doors until 6:00am, and tha's if they close their doors at all! You're never more than a quick five-minute cab ride away from a great dance club, and every night feels like a Saturday evening. And of course, it couldn't be easier to find a cab afterwards for a safe ride home.
As far as eating, there is a perfect mixture of local cuisine mixed in with the normal American staples. And if you have the craving for some good old American fast food, all the mainstays (McDonald's, Burger King, Taco Bell, Denny's, Pizza Hut and Papa John's to name a few) are not only located throughout the city, but will deliver to your door!
Having several options for fun should be a major factor when considering purchasing real estate, and Costa Rica delivers big time. Even if you are new to Costa Rica, you can check out websites, ask the locals, or get recommendations from the cab drivers to find your new favorite hangout. Remember, you're not just purchasing a new home, you're looking for a great place to live!


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Browsing RLE Progress Report, No. 066 (1962) by Title
Physical Acoustics
Johnson, L. E.; Maling, G. C., Jr.; Matchett, G. A.; Dean, L. W., III; Gentle, K. W.; e.a. (Research Laboratory of Electronics (RLE) at the Massachusetts Institute of Technology (MIT), 1962-07-15)
Physical Electronics
Nottingham, W. B. (Research Laboratory of Electronics (RLE) at the Massachusetts Institute of Technology (MIT), 1962-07-15)
Plasma Electronics
Rose, D. J.; Smullin, Louis D.; Haus, Hermann A.; Cogdell, J. R.; Hartenbaum, B. A.; e.a. (Research Laboratory of Electronics (RLE) at the Massachusetts Institute of Technology (MIT), 1962-07-15)
Plasma Magnetohydrodynamics and Energy Conversion
Hoppie, L. O.; Childs, W. H.; Norris, W. T. (Research Laboratory of Electronics (RLE) at the Massachusetts Institute of Technology (MIT), 1962-07-15)
Plasma Physics
Gruber, S.; Ingraham, J. C.; Buntschuh, C. D.; Hooper, E. B., Jr.; Coccoli, J. D.; e.a. (Research Laboratory of Electronics (RLE) at the Massachusetts Institute of Technology (MIT), 1962-07-15)
Processing and Transmission of Information
Pan, J. W.; Goblick, T. J., Jr.; Jelinek, F.; Massey, J. L.; Stiglitz, I. G.; e.a. (Research Laboratory of Electronics (RLE) at the Massachusetts Institute of Technology (MIT), 1962-07-15)
Radio Astronomy
Graham, J. W.; Barrett, Alan H.; Chung, V. K.; Weinreb, S.; Smullin, Louis D.; e.a. (Research Laboratory of Electronics (RLE) at the Massachusetts Institute of Technology (MIT), 1962-07-15)
Sensory Aids Research
Troxel, Donald E. (Research Laboratory of Electronics (RLE) at the Massachusetts Institute of Technology (MIT), 1962-07-15)
Signal Detection by Human Observers
Green, D. M. (Research Laboratory of Electronics (RLE) at the Massachusetts Institute of Technology (MIT), 1962-07-15)
Speech Communication
Paul, A. P.; Stevens, Kenneth N.; House, A. S.; Arnold, Jane B.; Heinz, J. M. (Research Laboratory of Electronics (RLE) at the Massachusetts Institute of Technology (MIT), 1962-07-15)
Statistical Communication Theory
Schetzen, M.; Van Trees, Harry L., Jr.; Bose, A. G.; Sakrison, D. J.; Algazi, V. R.; e.a. (Research Laboratory of Electronics (RLE) at the Massachusetts Institute of Technology (MIT), 1962-07-15)
Table of Contents
Davenport, Wilbur B., Jr.; Zimmermann, Henry J.; Harvey, George G. (Research Laboratory of Electronics (RLE) at the Massachusetts Institute of Technology (MIT), 1962-07-15)


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Q: Question about convergence of a series with a minus sign in front? I've been taught that convergence of the series $\sum_{n=1}^{\infty}a_n$ is equivalent to convergence of the sequence of partial sums $(\sum_{n=1}^{k}a_n)_{k\in\mathbb{N}}$. This was how convergence of a series was defined.
My question is (And this probably is obvious, but I am unsure since I know series don't behave in the same way as finite summations do) is convergence of the series $-\sum_{n=1}^{\infty}a_n$ equivalent to convergence of the sequence $(-\sum_{n=1}^{k}a_n)_{k\in\mathbb{N}}$?
Also, would it be correct to say $-\sum_{n=1}^{\infty}a_n = \sum_{n=1}^{\infty}-a_n$ for some sequence $a_n$? That is, would it be correct to say that these two series are the same series?

A: Note that we write  $\sum_{n=1}^{\infty}a_n$, even if the series $\sum_{n=1}^{k}a_n$ does not converge....so what would be the meaning of $-\sum_{n=1}^{\infty}a_n$ ? Of cousre, in case this happens it, we can prove that  $m \sum_{n=1}^{\infty}a_n=\sum_{n=1}^{\infty}m a_n$ , for any real number $m$.

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International Analysis: Conflicts of the Past Year Connected by Corruption
Tuesday, January 6 , 2015 - 18:07 (EET)
Op-Ed by Mary Beth Goodman — The Mark News — A retrospective look at the conflicts dominating the headlines in 2014 presents a grim picture of escalating conflict and human suffering. Underneath the headlines is a common thread connecting the rise of the Islamic State in Iraq and Syria (ISIS), the Ukrainian protesters in the Maidan, and the Nigerian families still desperately seeking someone to #BringBackOurGirls. That common thread is corruption. Corruption contributed to the collapse of the Iraqi military, allowing the expansion of ISIS. It led to Iraqi Prime Minister Haider al-Abadi's announcement that at least 50,000 "ghost soldiers" were discovered …read more Source: Peruvian...
International Analysis — Controlling Brazil's Amazonian Deforestation
Tuesday, October 21 , 2014 - 20:07 (EET)
Op-Ed by Philip Fearnside — The Mark News Brazil's Amazonian deforestation declined dramatically from 2004 to2012, and many have been quick to claim credit for the improvement. The Brazilian government has repeatedly claimed that the change is thanks to inspections and fines for illegal clearing, and soy multinationals claim their supply chains are now "green" thanks to self-governance. A mantra is omnipresent in Brasilia that deforestation is "under control." The corollary of this theory, of course, is that the government need not fear that its extensive plans to build highways and dams in Amazonia will provoke deforestation. Unfortunately, this is incorrect. First …read more Source: Peruvian...
Section: Peru
Peruvian Times (Peru) (3)
Tuesday, January 6 , 2015 - 18:07 (EET) Section: Peruvian Times (Peru)
Op-Ed by Mary Beth Goodman — The Mark News — A retrospective look at the conflicts dominating the headlines in 2014 presents a grim picture of escalating conflict and human suffering. Underneath the headlines is a common thread connecting the rise of the Islamic State in Iraq and Syria (ISIS), the Ukrainian protesters in the Maidan, and the...
Tuesday, October 21 , 2014 - 20:07 (EET) Section: Peruvian Times (Peru)
Op-Ed by Philip Fearnside — The Mark News Brazil's Amazonian deforestation declined dramatically from 2004 to2012, and many have been quick to claim credit for the improvement. The Brazilian government has repeatedly claimed that the change is thanks to inspections and fines for illegal clearing, and soy multinationals claim their supply...
International Analysis: The Temptations and Risks of Supporting Extremism
Wednesday, September 10 , 2014 - 20:07 (EET) Section: Peruvian Times (Peru)
Op-Ed by Shahram Chubin — The Mark News — In an era of fluid and contested borders and indirect and proxy conflicts (e.g. Ukraine ) the temptation for states to use radical groups for their own policy purposes is substantial. The US and its allies in Afghanistan, Israel in supporting Hamas at its inception, Iran in sponsoring various bodies named...


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Антизападни настроения или антиатлантизъм се отнася до широка опозиция или враждебност към хората, културата, или политиките на Западния свят. В много от съвременните случаи на Съединените щати и Обединеното кралство са предмет на обсъждане или враждебност. Антизападните настроения се среща в много страни, дори от самия Запад особено в европейските страни. Антизападни настроения има също и в мюсюлманския свят, за някои от които войните в Ирак, войната в Персийския залив, и войната в Афганистан се гледа като на водените от САЩ Западните кампании, които приличат на средновековните християнски кръстоносни походи срещу мюсюлманите. Друг фактор е продължаващата подкрепа от някои западни правителства специално Съединените щати за Израел.

Антизападни настроения в България
В България Антизападните настроения започват още през 1944 година, когато БКП застава на власт и влизането на България във Варшавския договор. След разпадането на комунизма в България Антизападните настроения за кратък период ги няма, но след като се създава БНС-НД Антизападните настроения продължава да ги има в България. Партия Възраждане, която след изборите през ноември 2021 година влиза в парламента, също проявява черти на антизападна партия.

Антизападни настроения в Китай
Антизападните настроения в Китай се увеличава от началото на 1990, особено сред китайските младежи. Забележителни инциденти, които са довели до значително антизападни реакции са през 1999 г. когато НАТО бомбардира китайското посолство в Белград. Въпреки наличните проучвания на общественото мнение показват, че китайците държат като цяло благоприятни възгледи към Съединените щати, остава подозрението върху мотивите на Запада към Китай произтича до голяма степен от исторически опит и по-специално на "век на унижение". Тези подозрения са се увеличили с "патриотичното възпитание на кампанията" на комунистическата партия.

Антизападни настроения в Русия
Освен от предишните напрежения на Студената война, Русия често е имала незначителни отношенията със Запада, особено под ръководството на Владимир Путин. Въпреки това, най-силните антизападни настроения лежат върху крайно десни руски националисти като партията "Велика Русия" която се ръководи от Андрей Савелиев и партията "Руско национално единство".

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redpajama_set_name: RedPajamaWikipedia


Look, don't get me wrong. I enjoyed these books, but it's not because they are overall well-crafted stories. It's because Sarah Rees Brennan is SO good at one or two aspects of story telling, it overshadows the weaknesses she displays in other aspects. She's got a stellar ability to craft characters you care about* and want to have happy endings. BUT. ..***Several spoilers below***I wasn't sure I was going to buy this book after the second book in the series suffered from middle-book-itis, but I don't regret it. I found the resolution between Jared and Ash and Kami satisfying, so for me, a romantic at heart, that made the purchase worthwhile. I was definitely disappointed in the resolution of the entire story arc, however. I felt as if the author was trying to make the stakes really high for all of the characters, and yet things frequently seemed very easy for the protagonists. Oh no! Bad guys are trying to steal Kami's brothers for an unholy sacrifice! How terrifying! Yet, they were awfully easy to chase away. Rob Lynburn is such a terrifying villain! He appears out of nowhere and exacts his revenge on Kami's mother! And yet it's awfully easy for Kami et al to slip in and out of the manor house whenever they feel they need to. I approved of the fact that not all the wizards on Rob's side were pure evil, and yet instead of fleshing them out into characters that felt real, these conflicted sorcerers were used as Deus Ex Machina. These varying stakes made the story feel choppy and the plot disjointed. It reminded of playing a video game where much of the action is exploration punctuated by moments of running from/fighting a boss who appears randomly. I don't know. I am glad I finished the trilogy, but I just feel like Sarah Rees Brennan could just do so much better. This is an entertaining, but ultimately flawed effort. Good characters, good plot IDEA, failed execution. I think she's still growing past her background as a fandom writer. Don't flame me! Fanfiction is lovely and has its place for sure! But I think generally-speaking, even the most beloved of fanfiction has more emphasis on the pairing rather than a well-developed plot. And I can't help but notice that her Jared and her Nick read very much like her flawed and angry Dracos. Give me another trilogy, Sarah. I'll buy and read it! But I need a bit more next time, or that will probably be my last one. ——————————————————————————————*Although I have to add that it's a big pet peeve of mine that they all [every single one] have EXACTLY the same sense of humor. .. it blurs the lines between them too much. The ONLY reason why she gets away with it is because SRB is actually very funny. So I spent an equal amount of time giggling as well as eye-rolling. Check it out!
From School Library Journal Gr 7 Up—Evil sorcerer Rob Lynburn, master of Aurimere House, has nefarious plans for those villagers in Sorry-in-the-Vale who won't join his side. He's strengthening his powers in preparation, which requires nothing less than human sacrifice. Kami Glass intends to stop him, but how? Her link with Jared has been severed—and he's missing. Her new link with Ash isn't helping and her mother is living up at Aurimere, serving Rob and his ilk. The good guys are outnumbered and out-magicked, but Kami refuses to give up. Research turns up one ritual that might help, but it could end up killing all of them. Brennan keeps the action coming and the dialogue zippy and quippy. Kami and her friends are a delight and readers will root for them to save themselves and their town and for everyone to end up kissing whoever they want to kiss. This trilogy ender isn't really a stand-alone though; readers will be well served by reading the previous, equally charming installments.—Stephanie Klose, School Library Journal –This text refers to the Library Binding edition.


Crispy, crunch and caramel pumpkin spice moose munch is a easy and sweet snack for fall! Baked and drizzled with chocolate, it's positively addicting!
One of my truest unabashed loves of the fall season is pumpkin spice. Coffee, pumpkin bread, pie, anything – bring it on. And even if Halloween is over, there is still plenty pumpkin spice-ing that can be done. I wanted to keep it rolling with this seriously amazing pumpkin spice moose munch that is a little too easy to devour.
But even though I am still rolling high on the pumpkin spice thing, I am also breaking every single rule I have about Christmas related things, too.
This year I started watching cheesy Hallmark Christmas movies BEFORE HALLOWEEN! Like, I don't even know who I am anymore. I'm living in a mix of wanting to keep fall perfectly preserved and also so excited about the upcoming winter season. Pumpkins, mint, hoaky movies, scarves, gooshy sweaters, it's all coming together to be the most perfect holiday mash up ever.
So whatever we are deciding to celebrate and revel in, pumpkin spice or Christmas, I'm going to just embrace it as it comes, hoaky holiday movies and all.
And because I mentioned it in my last post, I wanted to show you the photos of Emmett painting his pumpkins. Because who can resist chubby, naked babies!
Let's be real, it's stinkin' adorable!
Want more moose munch ideas?
In a sauce pan, melt butter. Whisk in sugar, corn syrup, and salt and bring to a boil. Let the mixture caramelize, boiling for about five minutes or until it turns golden brown. Remove from the heat. Whisk in the pumpkin spice, vanilla and the baking soda.
Pour popcorn into a VERY large bowl, and pour the caramel over the top. Using a spoon – the carmel is molten hot – combine the carmel and mix the popcorn. Spread the popcorn over two large lined cookie sheets. Line with parchment or silicone mats. Place in the oven for 30-45 minutes, toss and rotate the popcorn every 15 minutes.
While cooling, melt the chocolate and drizzle over the top of the cooled caramel popcorn. Sprinkle toffee over the warm chocolate so it sticks, if you are using it. Let the chocolate rest until cooled. Break popcorn into bite sized chunks and devour.


Inclusion of calculated values in reports.
Options for creating section subtotals, subheadings, and subfootings.
Support for hyperlinking (or drill-down functionality).
Integration with other business intelligence tools, such as the Financial Report Painter and data visualization.
For details about the many sophisticated Report Painter styling features, see Styling Reports With Report Painter.


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Mitchell Block, Board of Advisors
Mitchell Block is a documentary film producer. His works have won an Academy Award (Big Mama, 2001), been nominated (Poster Girl, 2006) and short-listed (The Testimony, 2006) for Oscars, as well. Carrier, his ten-hour landmark PBS series with its companion feature, Another Day in Paradise, won an Emmy and is one of the most-watched series in the history of PBS. It was the first and only time the US Navy allowed multiple film crews to embed on a warship for an entire six-month deployment. Block has made numerous acclaimed films including his short film No Lies which was selected to be part of the Library of Congress' National Register of Historical Films for preservation for all time. Each year only twenty-five films are added to the list from all American films produced since 1895. The other film's from Block's year include works by Martin Scorsese, George Lucas, Frances Ford Coppola, William Friedkin and Terrance Mallick. Block worked for seven years for Sheila Nevins, president of HBO Documentaries and Children's Programming as an acquisitions consultant finding emerging talent worldwide for HBO.
Paul Brooks, Board of Advisors
Paul Brooks is an entrepreneur, advisor, and investor who now leads 704Games and Peakland Innovation Group. Prior to founding Peakland, during his 22-year career in the NASCAR industry, Mr. Brooks served as President of NASCAR Media Group and Senior Vice President of NASCAR, and was responsible for all broadcasting, new media, licensing and consumer products, publishing, automotive aftermarket, and international business. He helped develop and consolidate NASCAR's long-term television and new media agreements with Fox, FX, NBC, Speed, and ABC/ESPN. As CEO of 704Games, he has recently launched new NASCAR video games on console, PC and mobile platforms that incorporate authentic NASCAR racing based on direct collaboration with top NASCAR drivers (i.e., NASCAR HEAT2.)
Cindy Chang, Board of Advisors
Cindy Chang is currently the Publishing Specialist at Netflix. She has had a long career in the entertainment industry, including with the Consumer Products Group, Partnerships & Licensing at NBCUniversal, overseeing the licensing of Universal films and NBC TV properties, and most recently leading their Global Publishing team. She launched the consumer products program for Illumination Entertainment and built the global Minions/Despicable Me consumer products franchise into a multi-billion dollar program at retail around the world.
Cynthia Cleveland, Board of Advisors
Cynthia is an expert in developing, translating and monetizing intellectual property rights into major global consumer brands and new businesses across diverse industries. Her combined businesses have generated over $4 billion in worldwide sales across consumer product, entertainment, and publishing brands. As CEO/President of five companies, she has a track record of identifying and capitalizing on emerging trends to create new businesses. Industry experience has included successfully navigating Fortune 500 companies, running a venture backed business, and launching an entrepreneurial digital business. With over 20 years of product development and marketing expertise, she has successfully directly introduced over 1,000 products for well-known companies such as Universal Studios, Carnation Foods, Mattel Toys, Teleflora floral gifts, and Imaginarium toy stores.


Winter Park Lodging Company has had a very busy summer and we have added quite a few new properties to our rental inventory. From an exclusive private home in the woods to a comfortable ski in out condo on the slopes of Winter Park Resort all can be found right with WPLCo.
A couple of the newest properties are located right on top of the shops of Winter Park Village. These are the Winter Park Village Lofts. The newest, most convenient lodging at Winter Park Base, the Lofts offer three and four bedrooms within feet of the village restaurants and resort lifts.
Winter Park Lodging Company offers WP Village Loft 101, Loft 106, Loft 108 , Loft 109, Loft 11 and Loft 112.
When it comes to luxury and convenience, these brand new lofts have it all. Sit back and relax with high-end furnishings, flat screen TVs, a gas fireplace, and a private garage. Just a short walk from the slopes, you'll be right in The Village at Winter Park, where you can walk downstairs to enjoy a meal at one of several delicious base village restaurants including The Cheeky Monk, Lime, Goody's and Back Bowl Soup Company.
Have a big group that wants base lodging? Well, the four lofts together can sleep 35 people very comfortably. That would be a big fun get together. Convenient Winter Park Base lodging steps from bars, restaurants and lifts in some of the nicest diggs at any Colorado ski resort.
So if you are looking for convenient, luxurious ski lodging the Winter Park Village Lofts can not be beat.
Snow is on the way so book your ski vacation lodging today.


In the EasyWorship Remote app, when tapping on Settings, and then Servers, if you do not see your computer listed in this Servers section, then it may be due to an issue with an Apple service called Bonjour which is needed in order for the Remote App to function properly.
1. Make sure EasyWorship 7 on your computer and the Remote app on your device is closed.
2. To see if you already have Bonjour installed, click on the Windows icon in the bottom left corner of your screen, and in the search bar type Control Panel.
3. Click on Control Panel at the top of your search results.
4. Then click on Programs and Features, or it may just say Programs.
5. This will open a list of all your installed programs. Scroll down and see if you have Bonjour installed.
6. Right-click on Bonjour, and click Uninstall. Then close that window.
8. After clicking this link, click on the Download button at the top to start the download.
9. Once it is downloaded, open that file and it will load up the Bonjour installation setup.
10. Click Next, then click I accept the terms in the license agreement, and click Next.
11. Click Next, and then uncheck the box that says Create Bonjour Printer Wizard desktop shortcut, and then click Install.
12. If a pop-up appears asking if you want to allow the app to make changes to your device, then click Yes.
13. Once it is done installing, click Finish.
14. Re-open EasyWorship 7 and make sure the Remote button is turned on and showing a green indicator.
15. Re-open the Remote app on your device and tap on Settings, and then tap on Servers.
16. Now your PC name should show up in the list.
17. Tap on your PC name, and then in EasyWorship 7, click the Remote button, and then click Pair.
Now you should be connected with the EasyWorship Remote app.


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Arc 2000 is a mountain top resort noted for its skiing. The quality of the snow and length of the ski season have made it an unmissable luxury resort.
The resort is located on the north slope of Vanoise en Tarentaise to the east of the French Savoie department, in the Rhône-Alpes region.
The Arc 2000 village belongs to the Paradiski ski area: 435 kilometres of snow and 261 slopes, nearly half of which are red or black slopes.
Arc 2000 offers immediate access to the ski slopes and the Aiguille Rouge massif. This 3,226 metre summit is the starting point of the mythical 7 kilometres descent to Villaroger at 1200 kilometres.
Always concerned with safety and comfort, the Arc 2000 center is completely pedestrianised.
In winter, the slopes offer 200 kilometres of high-quality powder. Snow lovers can use 106 slopes in total.
During summer, hiking lovers can enjoy the alpine pastures and wide spaces in Savoie for long hikes.
From Taj-I-Mah, you can discover Col de la Chal, the summit of Aiguille Grive, the Vanoise park or even the refuge of Mont Pourri.
During your hikes, take the time to relax and enjoy the crystal waters of these high-altitude lakes to refresh yourself.
To the east of Arc 2000 is the Combes lake. From there you can admire Mont Blanc which reaches 4,809m to the north and Aiguille Rouge at 3,227m to the east.
The 5-star Taj-I-Mah hotel enjoys an exceptional location in the Arc 2000 resort, with a magical view over the complex and the slopes.
The hotel can be easily accessed by car or train.
Leave the A430 motorway at Albertville, then follow Moûtiers on RN 90 and Bourg-Saint-Maurice. Then drive up to the 4 Les Arcs resorts.
The Taj-I-Mah is located in front of the "le Cabriolet" cable car. Follow the arrows from the entrance to the resort.
For your safety and peace of mind, please contact us to book a taxi.
The closest train station is Bourg-Saint-Maurice (23 kilometres), below the resort.
Buses and taxis are available to bring you to Arc 2000.
Bus or taxi transfers to Arc 2000.


american national character essay. The first, when war was declared on Germany and its al- lies in April 1917, was marked by varying reactions by U. intellectuals, many of whom opposed entry into the conflict on neutralist grounds. intervention in World War I1 was felt by anthropologists to demand an active engagement.
long dominance of Regenten class, the merchant patricians of the cities (Elias. 1996: 10-13). In this essay, I want to argue that the equivalent central historic experience shaping American national character is of their country constantly becoming more powerful relative to its neighbours. This has had long-term and all-per-.


William J. Winter, while serving as auxiliary bishop of the Roman Catholic Diocese of Pittsburgh, confirmed an estimated 45,000 Catholics?
For other Christian interpretations of Confirmation, see Confirmation (Christian sacrament).
A Latin Rite bishop administering confirmation in the 14th century. Painting by Rogier Van der Weyden.
In the Latin-Rite (i.e., Western) Catholic Church, the sacrament is to be conferred on the faithful at about the age of discretion (generally taken to be about 7, but most people are confirmed at ages 13-14), unless the Episcopal Conference has decided on a different age, or there is danger of death or, in the judgement of the minister, a grave reason suggests otherwise . The number of Episcopal Conferences that have set a later age has diminished in recent decades, and even in those countries a bishop may not refuse to confer the sacrament on younger children who request it, provided they are baptized, have the use of reason, are suitably instructed and are properly disposed and able to renew the baptismal promises (letter of the Congregation for Divine Worship and the Discipline of the Sacraments published in its 1999 bulletin, pages 537-540).
In the Latin-Rite (i.e., Western) Catholic Church, the sacrament is customarily conferred only on people old enough to understand it, and the ordinary minister of Confirmation is a bishop. Only for a serious reason may the diocesan bishop delegate a priest to administer the sacrament (canon 884 of the Code of Canon Law). However, a priest may by law confer the sacrament, if he baptizes someone who is no longer an infant or admits a person already baptized to full communion, or if the person (adult or child) to be confirmed is in danger of death (canon 883).
In Eastern Catholic Churches, the usual minister of this sacrament is the parish priest, using olive oil consecrated by a bishop (i.e., chrism), and administering the sacrament immediately after Baptism.
The practice of the Eastern Churches gives greater emphasis to the unity of Christian initiation. That of the Latin Church more clearly expresses the communion of the new Christian with the bishop as guarantor and servant of the unity, catholicity and apostolicity of his Church, and hence the connection with the apostolic origins of Christ's Church. .
Although Confirmation is sometimes called the 'sacrament of Christian maturity,' we must not confuse adult faith with the adult age of natural growth, nor forget that the baptismal grace is a grace of free, unmerited election and does not need 'ratification' to become effective.
In the early twentieth century, Pope Pius X encouraged the admission of children to reception of the Eucharist as soon as they reached the age of reason, in contrast to the later age at which they had been admitted for some centuries. Since the age for Confirmation remained as before, those being confirmed generally received the Eucharist several years earlier. However, the three sacraments of Christian initiation, Baptism, Confirmation and Eucharist, are increasingly conferred, within the Latin-Rite Catholic Church, in the traditional order, which is obligatory when an adult is baptized.
The Catholic Church teaches that, like Baptism, Confirmation marks the recipient permanently, making it impossible to receive the sacrament twice. It accepts as valid a Confirmation conferred within Churches, such as the Eastern Orthodox Church, whose Holy Orders it sees as valid through the apostolic succession of their bishops. But it considers it necessary to administer the sacrament of Confirmation, in its view for the only time, to Protestants who are admitted to full communion with the Catholic Church.
The "soldier of Christ" imagery, which remains valid  but is downplayed if seen as part of the once common idea of Confirmation as a "sacrament of maturity" , was used as far back as 350, by St Cyril of Jerusalem. In this connection, the touch on the cheek that the bishop gave while saying "Pax tecum" (Peace be with you) to the person he had just confirmed was interpreted in the Roman Pontifical as a slap, a reminder to be brave in spreading and defending the faith: "Deinde leviter eum in maxilla caedit, dicens: Pax tecum" (Then he strikes him lightly on the cheek, saying: Peace be with you) (cf. the knightly custom of the accolade). When, in application of the Second Vatican Council's Constitution on the Sacred Liturgy,  the Confirmation rite was revised in 1971, mention of this gesture was omitted. However, the French and Italian translations, indicating that the bishop should accompany the words "Peace be with you" with "a friendly gesture" (French text) or "the sign of peace" (Italian text), explicitly allow a gesture such as the touch on the cheek, to which they restore its original meaning. This is in accord with the Introduction to the Rite of Confirmation, 17, which indicates that the episcopal conference may decide "to introduce a different manner for the minister to give the sign of peace after the anointing, either to each individual or to all the newly confirmed together."
1285-1321. Catechism of the Catholic Church.
^ St. Ambrose, De myst. 7, 42: PL 16, 402-403.


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Where do memories live?
September 7, 2016 PLOS Blogs Basic Neuroscience Neuroscience
Memory is one of the many brain functions that have fascinated generations of neuroscientists. It is a cerebral phenomenon that accompanies us throughout our lives and gives a colorful meaning to our experiences. Good and bad memories shape our personality and our way of interacting with the world. Among the questions brain researchers and many others have long pondered are: How and where are memories born? Who or what is responsible for their creation? Where do they live?
And while the mechanisms involved in encoding, storing and retrieving memories have attracted a great deal of attention, the processes that allocate individual memories to a specific subset of neurons within a complex neural network have not been fully elucidated. Obviously, a memory must be allocated somewhere in the brain and memory allocation is becoming an extremely fascinating field.
Memories depend on allocation: who and where
Memory allocation, a recently discovered phenomenon of memory formation, accounts for how specific neurons (neuronal allocation) or even synapses (synaptic allocation) are committed to storing a specific memory (Rogerson et al., 2014). Synaptic and neuronal allocation mechanisms work closely in building and governing the networks of neurons implicated in the acquisition, stabilization and retrieval of information within the black box which is our brain. Therefore, understanding the molecular, cellular and systemic mechanisms, as well as the implications of these processes, is essential since this knowledge may elucidate how memory allocations are coordinated and integrated during memory formation and consolidation.
In a recent research article published in PLOS ONE, Thomas Rogerson and colleagues had a closer look at how molecular and cellular mechanisms regulate the allocation of memories to discrete neurons in the amygdala, a brain region highly involved in learning and memory processes.
Molecular mechanisms of memory allocation
Increasing evidence suggests that the transcription factor cAMP-response element binding protein (CREB) plays a critical role in neuronal allocation in the lateral amygdala (LA) (Silva AJ et al., 2009, Sano Y et al., 2014), a structure required for learning the association between a conditioned stimulus (CS, such as a tone) and an unconditioned one (US, such as a foot-shock) in auditory-fear conditioning (AFC). The AFC paradigm relies on the following principle: when a mouse receives a foot-shock in a particular context, an engram forms to encode the memory trace of that event. Once that memory forms, the set of neurons that make up the engram are more likely to be activated. Interestingly, the more excitable neuronal cells are, the more likely they are to be recruited into a specific engram.
Using cellular, behavioral and optogenetic tools, Rogerson and colleagues tested whether it was possible to recruit the encoding of an auditory-fear conditioning (AFC) memory to a subset of neurons with increased excitability, as it has been previously shown for CREB (Zhou Y et al., 2009). In fact, the same laboratory, led by Alcino Silva, a Professor of Neurobiology at the David Geffen School of Medicine at UCLA, has shown that CREB regulates neuronal allocation by modulating neuronal excitability (Zhou Y et al., 2009).
In this elegant study, optogenetic studies in the lateral amygdala (LA) were used to explore whether CREB and neuronal excitability regulate which neurons are to encode an emotional memory such as fear. Indeed, the authors were able to allocate an emotional memory to a subset of LA neurons using either CREB or a transient optogenetically-controlled increase in excitability during learning. Surprisingly, "opto-activation of this specific subset of LA neurons resulted in recall of the memory" said Thomas Rogerson, the leading author of the study. In fact, post-training optogenetic activation of neuronal cells infected with a viral CREB was sufficient to elicit recall of an auditory-fear conditioning memory. Memory recall, triggered by light-driven stimulation of Channelrhodopsin-2 in neurons virally expressing CREB, was higher than that observed after activating a similarly infected population of neurons with a control virus. These results "suggest that the AFC memory was disproportionately allocated to the neurons with higher CREB, so that Channelrhodopsin-2 activation of these neurons post-training resulted in more robust recall than activation of a similar number of neurons with normal levels of CREB in controls" concluded the authors. In addition to these experiments, the team of Dr. Alcino Silva showed that "increasing neuronal excitability in a subset of lateral amygdala neurons right before training increased the probability that these neurons would be involved in memory". These results suggest that increases in excitability can bias memory allocation only when they takes place during training, whereas increases in excitability immediately after learning do not affect neuronal allocation. As discussed in the article, "altogether, these results strongly support the hypothesis that increases in neuronal excitability are a mechanism by which higher levels of CREB bias memory to a subset of neurons in a neural circuit".
Could increased excitability solely explain the phenomena of memory allocation? This is unlikely since "the refinement of a memory trace to a subset of eligible neurons relies on a number of other cellular and circuit mechanisms, such as lateral inhibition mechanisms in which the most excitable neurons inhibit the formation of the memory in less excitable neurons" reported the authors.
In conclusion, this research remarkably contributes to unfolding the various mysteries of memory processes, suggesting that increases in neuronal excitability and cell tagging may together determine the exact sites where, and how, memories are to be stored and recalled. It is thus tempting to hypothesize that the research of these authors may lead to important, groundbreaking discoveries aiming to repair broken neural circuits involved in memory-related dysfunctions as observed in Alzheimer's disease or Post-Traumatic Stress Disorder.
Rogerson T, Jayaprakash B, Cai DJ, Sano Y, Lee YS, Zhou Y, Bekal P, Deisseroth K, Silva AJ. Molecular and Cellular Mechanisms for Trapping and Activating Emotional Memories. PLoS One. 2016 Aug 31;11(8):e0161655. doi: 10.1371/journal.pone.0161655. eCollection 2016.
Silva AJ, Zhou Y, Rogerson T, Shobe J, Balaji J. Molecular and cellular approaches to memory allocation in neural circuits. Science. 2009 Oct 16;326(5951):391-5. doi: 10.1126/science.1174519. Review.
Sano Y, Shobe JL, Zhou M, Huang S, Shuman T, Cai DJ, Golshani P, Kamata M, Silva AJ. CREB regulates memory allocation in the insular cortex. Curr Biol. 2014 Dec 1;24(23):2833-7. doi: 10.1016/j.cub.2014.10.018. Epub 2014 Nov 13.
Zhou Y, Won J, Karlsson MG, Zhou M, Rogerson T, Balaji J, Neve R, Poirazi P, Silva AJ. CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala. Nat Neurosci. 2009 Nov;12(11):1438-43. doi: 10.1038/nn.2405. Epub 2009 Sep 27.
Rogerson T, Cai DJ, Frank A, Sano Y, Shobe J, Lopez-Aranda MF, Silva AJ. Synaptic tagging during memory allocation. Nat Rev Neurosci. 2014 Mar;15(3):157-69. doi: 10.1038/nrn3667. Epub 2014 Feb 5. Review.
The author is grateful to Teresita Cruz for assistance.
Featured image: Fe Ilya, Flickr.
Any views expressed are those of the author, and do not necessarily reflect those of PLOS.
Giuseppe Gangarossa received his PhD in Biomedical Sciences, specialty Neuroscience, from the University of Bologna. He has been a visiting fellow at the Karolinska Institutet (Sotckholm, Sweden), the French Inserm (Montpellier, France) and the Collège de France (Paris, France). Giuseppe is currently Assistant Professor of Physiology at the University Paris Diderot. His main research topic is dopamine-related brain disorders. You can follow him on twitter @PeppeGanga


First comes news that Google is shutting down iGoogle, its popular Web portal.
Now I find out that Mozilla is pulling the plug on Thunderbird, its popular email client. What's next: Microsoft turning off Skype?
If you're a regular Simply Business reader, well, you're awesome. Also, you're aware that I've been test-driving Thunderbird for the past few months. It's not perfect by any stretch, but it's definitely among my favorite mail programs.
The good news is it's not being killed outright; rather, Mozilla simply won't be developing it any further. That means we should be able to continue using it for many moons to come -- especially if some third-party developer picks up the Thunderbird ball and runs with it.
From the makers of the SoftMaker office suite, this surprisingly comprehensive mail client is especially good at synchronizing with Gmail, including Google Calendar and Contacts.
It can also import from Microsoft Outlook, a big plus for anyone looking to migrate from that program. The free version limits you to two accounts; if you need more, the unlimited Pro version costs $49.95.
My one complaint with emClient: as with Thunderbird, any message you reply to or forward isn't automatically marked as read -- a rather ridiculous oversight, in my humble opinion.
More than just a mail client, EssentialPIM is an old-school information manager, offering not only calendar, contact, and task management, but also a password organizer and notes manager.
The $39.95 Pro version adds the option of syncing with Outlook for those who need that option.
Although Microsoft will soon retire the Windows Live brand, Windows Live Mail will undoubtedly live on (even if it does so under a different name). And that's a good thing, as it's arguably the most visually appealing and user-friendly mail program out there.
Good choices, no? Of course, if you've found a freebie mail client you like better, by all means shout it out in the comments. Personally, I'm still trying to figure out where to hang my mail hat.
I do need a way to preserve my mammoth Outlook PST file (which, admittedly, was going to be an issue with Thunderbird anyway), so I'm still undecided.


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text:
CONTACT WILL
Unite America First
Democrat promises
Justice Department Drops Felony Charges Against #WalkAway Founder Brandon Straka Who Pled Guilty To Class B Misdemeanor
Rich Welsh
SOURCE: YouTube video screenshot
On Wednesday, Brandon Straka, the Founder of the #WalkAway movement, pled guilty to a Class B misdemeanor of disorderly conduct for being on or remaining on US Capitol grounds on January 6. To be clear, a Class B misdemeanor is on the same level as graffiti.
The Democrats and their boot-licking sycophants in the mainstream news media wanted you to believe that social media influencers, people like Straka who were there at the Capitol on January 6 were all Qanon white supremacist conspiracy theorist Russian agents who wanted to take over the US government and after the insurrection they would install a new emperor of the United States.
The truth of the matter is Brandon Straka never entered the Capitol building. He never stepped one foot inside. He never committed an act of violence and never encouraged anyone to commit violence or enter the building. I bet you didn't hear that on CNN.
According to sources familiar with the case, Straka was on the east side of the Capitol building. The riot broke out on the west side. There were no Capitol Police at that time on the east side, probably because they weren't needed. Nothing suspicious was going on there. According to the source, at the time he approached the area, there were thousands of people who looked calm and were holding signs. There were no signs of violence and no angry mobs.
Straka was on actual Capitol grounds for about 10 minutes. He was in the surrounding area for 30 minutes, tops. He committed no acts of violence and he didn't encourage anyone else to commit violence. He had no intentions of causing trouble. Like 99% of the crowd, Straka was there to have his voice heard and to support President Donald Trump. The people there simply wanted then Vice President Mike Pence to hold off the certification of states until a series of election audits were performed. That was in Pence's power to do, but he declined to do it.
Americans are known to protest. Under the Constitution, American citizens have the right to redress their grievances with the government. Unless, of course, you're a Trump supporter who caused major problems for the Democratic Party's membership numbers.
For the small amount of time Straka was on Capitol grounds, the federal government has turned his life upside down. For less time than it takes to get a Starbucks Pumpkin Spice Latte, Facebook permanently banned not only the official #WalkAway Campaign page, but Straka's personal page and the personal pages of those who work for the movement. For 10 minutes and never entering a building, Straka was subsequently banned from using PayPal, Stripe, Venmo and many other services, in an effort to ensure he cannot earn a living.
Starting in early 2017, Straka created and grew a campaign against violence, against incivility. He championed a cause to bring respect and civil discourse back into politics.
Straka created an amazing network of people who got fed up with the Democratic Party making promises before every election they never meant to keep. The movement is made up of people like Straka who got sick of the lies, the misinformation and disinformation that is spread every day by the Left. Initially posting a video on YouTube giving his reasons why he was walking away from the Democratic Party, he started something that I don't think even he knew what it would one day grow into.
Hundreds of thousands of Americans joined the #WalkAway movement, and that's why the Democrats went after him for only 10 minutes of time spent on Capitol grounds when he didn't commit any acts of violence and never stepped one foot inside a building and never encouraged anyone to go inside.
Straka was more than just the #WalkAway movement. He became a status symbol of a disobedient middle class that stands up to political corruption and demands accountability from its leaders. He campaigned for nearly every facet of Trump's America First movement. I dare say there are many politicians who got elected in part because of #WalkAway and in part through Straka's efforts to campaign on their behalf.
And they all abandoned him in his time of need. I haven't heard of any GOP politicians or conservative groups reaching out to him since January 6, including the Trump organization. For whatever reasons, they simply turned their backs on him after all he has done for the movement. It's not right.
The Democrats targeted Straka because of how effective he is at the grassroots level and the Republicans have not reached out. Only Democrats leave people behind. That's not the America First way.
Visit Brandon Straka's website to donate and learn about his future plans by clicking HERE.
In this article:Brandon Straka, January 6
Reality Check Podcast
Reality Check with Will Johnson
Will has come to realize that there are several things we need to do to make a difference in the future of America. First, we need to educate the youth on our constitution and responsibilities as citizens of America. And second, we need to bring the truth to our nation and hold our government officials accountable. We need to make sure that they are representing our interests.
WARS AND RUMORS OF WARS HAPPENING
byWill Johnson
Dems fail to condemn Antifa as they terrorize Atlanta. Biden says he will not let Republicans wreck the economy. Biden is sued over the Border. FBI agent arrested for colluding with Russia.
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WILL YOU TAKE THE DIGITAL IMPLANT? WILL YOU SPONSOR AN ILLEGAL?
THE TUG-A-WAR ON CAPITOL HILL
ULTRA MAGA REPUBLICAN
Now they're coming from CANADA: Northern border sees 743% spike in illegal migrants trying to cross in a year due to 'easier entry than Mexico' – as cops release eerie images of asylum seekers trudging through 12F snow
Trump Announces Plan To Build 'Impenetrable Dome' To Protect U.S. From Nuclear Threats
Patriot Supply
Qanon Shaman Guy Will Take a Plea Deal For Walking Into The Capitol on January 6
We all remember the "QAnon Shaman" guy who dressed up in a coyote's skin with a horned helmet and carrying an American flag who...
Rich WelshSeptember 3, 2021
Ashli Babbitt Family Attorney To File $10 Million Wrongful Death Lawsuit Against Capitol Police Officer
A Capitol Police officer "ambushed" unarmed Air Force veteran Ashli Babbitt and shot her during the January 6 riot at the Capitol building according...
Rich WelshAugust 7, 2021
Biden Administration Using a List of Social Media Influencers Who Were Followed By January 6 Defendants
The appalling treatment of the so-called "suspects" who were inside or even near the Capitol building on January 6 has been discussed by many....
Rich WelshJuly 13, 2021
Copyright © 2022 Unite America First. Turbocharged by Adrevv


This is Dronark Future House Essentials Vol.1. Best samples in the game for the lately upsurging genre, Future House!
The included samples have been processed and selected carefully to give you the inspiration. Just add this pack into your library and you're good to go for your next Future House banger.
Serum v. 1.21b3 or higher to access the presets.


Some time ago I found that my company was investing in a number of the Segways and any person keen on utilizing them could go to a training course. Not long ago i went to the training course and I have to admit I am completely content with the Segway.
One of the most amazing facet of the Segway is it's acceleration. They will top out at about 12.5 miles hourly which turned out to be a very good rate of speed. They speed up quickly and an officer could quickly catch up with a suspect running on foot or using a bicycle.
Understanding how to run the Segway required some time but after having a few hours I was feeling invincible as I hopped off curbs and raced down sidewalks and also over grass. The Segway managed flawlessly when jumping off solid curbs at max speed which happened to be a must considering pursuing suspects or reacting promptly to calls for support.
I was just as surprised to find out that the Segway can run over gravel, grass and dirt terrain. I thought the Segway must have been a sidewalk only unit but it's not. The Segway went slow while dealing with grass but it could take me down and up a grassy hill.
An additional amazing attribute is the Segway's capability to turn and manuever. I could ride down occupied sidewalks while very easily manuevering around persons, vehicles, light poles, and also other hurdles. One of the most remarkable attribute is the capability to immediately stop the Segway when traveling at max speed. When rushing at 12.5 miles per hour ,I was allowed to immediately stop the Segway by pulling on the handlebar and leaning back. This unique feature is ideal for those circumstances where you have to stop and leave the Segway for an urgent situation or to prevent a crash.
I was first worried of the possibility of the Segways to be stolen if authorities placed them unprotected while performing inspections that demanded them to avoid their Segways. I found that our Segways include an audible alarm that is triggered if somebody touches this after the police officer activates the security alarm. The Segways are extremely heavy and it might be no convenient job for somebody to take one up and run away with it.
While on the Segway you can considerably better keep an eye on your instant surroundings since you are higher than everybody else close by. Officers are highly visible to the public while on Segways which is an excellent crime deterrent.
The Segway will significantly help a Police Department in tasks wherever police officers are addressing huge crowds of people or overloaded urban areas like for example around downtown areas and flat complexes. Additionally it is an excellent Community Policing device in that it should get officers out of their cruiser motorcycles and being closer with the society. Police officers can quickly address and get in touch with people while on the Segway.
I do believe the Segway is the perfect Community Policing device however it is speedily enough and calm enough to be used for drugs enforcement and many more patrol tasks.


Discussion in 'Ask the Rules Team' started by Pinsir52, Feb 25, 2008.
During setup, I set my basic and prizes, but my opponet mulligans. I draw my card, and it is another basic. Am I allowed to put it down (face down) and/or switch it the the face down active?
You can put it face down on your bench, but you can't change it with the Pokemon that you put in the Active postion.
That remains the Pokemon that you start with as your Active.
... and just because someone may wonder, if by chance you have placed your Active and 5 Pokemon on your Bench during setup (that would have been quite an opening hand) you cannot switch out one of the Benched Pokemon if you draw a better one for a Mulligan.


When it comes to SEO success and driving user engagement with your website, semantics can be everything. But more specifically, semantic content optimization is key to understanding what your users are looking for. This post from Search Engine Land outlines what semantic content is, and how you can optimize for it on your webpage.
The most basic way to understand the term "semantic content" is that your webpage aims to meet the needs of an even broader range of visitors than you may have originally intended. Because of the way that Google organizes the top results in their search rankings, it's important not to paint your website into a corner or only offer value to a niche group of people. Not only would that be devastating for your SEO ranking, but people who *could* have been interested in your product or service will just find the information they need on a different, broader company website.
In order to appeal to a larger audience, follow this guide for optimizing for semantic content, from asking your users what information is most valuable to them to making sure the user experience on your site is seamless and usable. Read on for even more tips.


text:
Q: Recursive function call hanging, Erlang I am currently teaching my self Erlang. Everything is going well until I found a problem with this function.
-module(chapter).
-compile(export_all).

list_length([])      ->   0;
list_length([_|Xs])  ->   1+list_length([Xs]).

This was taken out of an textbook. When I run this code using OTP 17, it just hangs, meaning it just sits as shown below.
1> c(chapter).
{ok,chapter}
2> chapter:list_length([]).
0
3> chapter:list_length([1,2]).

When looking in the task manager the Erlang OTP is using 200 Mb to 330 Mb of memory. What causes this.

A: It is not terminating because you are creating a new non-empty list in every case: [Anything] is always a non-empty list, even if that list contains an empty list as its only member ([[]] is a non-empty list of one member).
A proper list terminates like this: [ Something | [] ].
So with that in mind...
list_length([])      ->   0;
list_length([_|Xs])  ->   1 + list_length(Xs).

In most functional languages "proper lists" are cons-style lists. Check out the Wikipedia entry on "cons" and the Erlang documentation about lists, and then meditate on examples of list operations you see written in example code for a bit.
NOTES

*

*Putting whitespace around operators is a Good Thing; it will prevent you from doing confused stuff with arrows and binary syntax operators next to each other along with avoiding a few other ambiguities (and its easier to read anyway).

*As Steve points out, the memory explosion you noticed is because while your function is recursive, it is not tail recursive -- that is, 1 + list_length(Xs) leaves pending work to be done, which must leave a reference on the stack. To have anything to add 1 to it must complete execution of list_length/1, return a value, and in this case remember that pending value as many times as there are members in the list. Read Steve's answer for an example of how tail recursive functions can be written using an accumulator value.

A: Since the OP is learning Erlang, note also that the list_length/1 function isn't amenable to tail call optimization because of its addition operation, which requires the runtime to call the function recursively, take its return value, add 1 to it, and return the result. This requires stack space, which means that if the list is long enough, you can run out of stack.
Consider this approach instead:
list_length(L)           -> list_length(L, 0).
list_length([], Acc)     -> Acc;
list_length([_|Xs], Acc) -> list_length(Xs, Acc+1).

This approach, which is very common in Erlang code, creates an accumulator in list_length/1 to hold the length value, initializing it to 0 and passing it to list_length/2, which does the recursion. Each call of list_length/2 then increments the accumulator, and when the list is empty, the first clause of list_length/2 returns the accumulator as the result. But note that the addition operation here occurs before the recursive call takes place, which means the calls are true tail calls and thus do not require extra stack space.
For non-beginner Erlang programmers, it can be instructive to compile both the original and modified versions of this module with erlc -S and examine the generated Erlang assembler. With the original version, the assembler contains allocate calls for stack space and uses call for recursive invocation, where call is the instruction for normal function calls. But for this modified version, no allocate calls are generated, and instead of using call it performs recursion using call_only, which is optimized for tail calls.


We encourage independent thinkers who are prepared to lead.
From the performance stage to the science lab, from the athletics to Chapel - St. Mary's girls learn to collaborate, inspire others, and achieve their goals. It's no surprise that St. Mary's graduates are at the forefront of developments in science, math, technology, the arts, healthcare, education, the military, and public service. In Memphis and across the planet, St. Mary's girls make a positive impact.


text:
package es.uvigo.ei.sing.biomsef.entity

import org.scalacheck.Arbitrary.arbitrary
import org.scalacheck.Gen

object Generators {

  lazy val nonEmptyStringGenerator = Gen.alphaStr suchThat {
    str => str.trim split "\\s+" forall (!_.isEmpty)
  }

  lazy val documentGenerator = documentTupleGenerator map Document.tupled

  lazy val documentTupleGenerator = for {
    id        <- arbitrary[Option[Long]] map (_ map DocumentId)
    title     <- nonEmptyStringGenerator map Sentence
    text      <- nonEmptyStringGenerator
    pubmedId  <- arbitrary[Option[Long]] map (_ map PubMedId)
    annotated <- arbitrary[Boolean]
    blocked   <- arbitrary[Boolean]
  } yield (id, title, text, pubmedId, annotated, blocked)

  lazy val keywordGenerator = keywordTupleGenerator map Keyword.tupled

  lazy val keywordTupleGenerator = for {
    id          <- arbitrary[Option[Long]] map (_ map KeywordId)
    normalized  <- nonEmptyStringGenerator map Sentence
    category    <- Gen.oneOf(Seq(Compound, Drug, Gene, Protein, Species, DNA, RNA, CellLine, CellType))
    occurrences <- Gen.choose(0, Long.MaxValue) map Size
  } yield (id, normalized, category, occurrences)

  lazy val annotationGenerator = annotationTupleGenerator map Annotation.tupled

  lazy val annotationTupleGenerator = for {
    id            <- arbitrary[Option[Long]] map (_ map AnnotationId)
    documentId    <- arbitrary[Long] map DocumentId
    keywordId     <- arbitrary[Long] map KeywordId
    startPosition <- Gen.choose(0, Long.MaxValue / 2) map Position
    endPosition   <- Gen.choose(startPosition.value, Long.MaxValue) map Position
    text          <- nonEmptyStringGenerator map Sentence
  } yield (id, documentId, keywordId, text, startPosition, endPosition)

}

redpajama_set_name: RedPajamaGithub


Fresh Princess Story & Activty Time | Let's Play Books!
Join us as we read Fresh Princess and each child will receive a special Fresh Princess activity book & other fun goodies!
Based on The Fresh Prince created by Will Smith, Destiny is the Fresh Princess.
Meet Destiny—a cool, energetic, and strong-willed young girl who approaches every day with her own signature style! That is, until she moves to a brand-new neighborhood, where nothing looks quite the same as it did at her old house.
Even with new challenges and new friends to make, Destiny always has a plan. With a few reminders from her loving family and after remembering what being the Fresh Princess is all about, she may just take the leap and jump right in!
Purchase of the book is your ticket to the event. One book per family (up to 3 children).


text:
How Paywalls Work
by Cristen Conger
The New York Times paywall went live on March 28, 2011.
alextorrenegra/Flickr Creative Commons
On March 28, 2011, a grand online experiment commenced. Or rather, re-commenced.
At the stroke of 2 p.m., a paywall, or online system charging visitors to access content, went live on The New York Times Web site, and many wondered whether the "Gray Lady" was about to fall flat on her face by charging readers to browse articles. After all, The Times had already dabbled in this concept in late 2005 when it attempted to cordon off its most popular opinion columns and archived articles under the TimesSelect paywall. The paper dismantled TimeSelect in 2007, a defeat of sorts that seemed to make the stakes for the second go-around even higher.
Granted, this shiny new paywall is designed much differently than TimesSelect. Rather than charging an upfront monthly or yearly rate ($7.95 and $49.95, respectively), the media machine opted for a metered approach instead. Visitors can access their first 20 articles per month at no cost, but have to fork over for online subscriptions beyond that [source: The New York Times]. Or if people choose to go rogue, they can simply "hop over" the paywall, which we'll discuss in more detail later.
Paywalls are of particular concern to the Web sites of print publications, hence the back-and-forth over The New York Times. In the past, a number of newspapers and magazines have attempted to charge readers for access, and then later backed down due to dwindling online traffic. As many print publications folded and shrank during the recession, sites struggled to figure out how to bridge their revenue gaps, and for a while, it seemed like online advertising surrounding freely accessible content was the answer.
However, The Times and other publications aren't so sure that ads are profit panacea they've hoped for. And since it costs these businesses to serve up the articles the wired public gobbles up for free, isn't it time users start footing some of the bill? That's been the question for many online content providers -- the folks who bring you libraries of music, movies, television, commentary, journalism and research -- as they struggle over whether or not to charge visitors for access, streaming and downloads. Also, the rise of mobile devices and tablet computing is revolutionizing traditional content and providing consumers with new ways to interact and engage with online publications, which some consider worth a premium toll. And so the debate over free versus paid online content rages on.
5 Ways to Make Money on the Internet
How Penny Per Page Might Work


text:
About Greek Parliament in Athens City
Updated: 2020/01/15 -Home » About Greek Parliament in Athens City » About Greek Parliament in Athens City
The Greek Parliament or Hellenic Parliament is the parliament of Greece, located in the center of Athens City. Moreover it is the Old Royal Palace, an austere Neoclassical building, overlooking Syntagma Square in Athens. In addition it is the supreme democratic institution that represents the citizens through an elected body of Members of Parliament.
The Greek Parliament is a three-floor building that has two entrances. First one of the west side which is used for the entering of the MPs in the building. Second one on the front side, facing the Tomb of the Unknown Soldier. Next to the Parliament House, there are the National Gardens and Zappeion Megaron. The construction of this building lasted from 1836 till 1842. It was designed by the German architect Friedrich von Gartner. Alos, it is a unicameral legislature of 300 members, elected for a four-year term. During 1844–63 and 1927–35 the parliament was bicameral with an upper house, the Senate, and a lower house, the Chamber of Deputies, which retained the name Vouli.
Originally, it served as the Royal Palace for the Greek Kings. The main Chamber of the Greek Parliament is housed in the ground floor, in the once Ball Room. What;s more it is amphitheatrical in layout and a vi trail room provides natural light in the daytime. The seating of the MPs is arranged in five circular sectors. A balcony above the Chamber is used as the visitor's gallery.
An almost identical, smaller chamber was built in the second floor for the use of the Senate, but since the Senate was abolished, this chamber is used today for party meetings.
See the Greek Parliament with one of our tours:
Athens Morning Sightseeing Tour With Visit Of Acropolis of Athens and New Acropolis Museum
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8 Day Combined Tour Package to the Islands and Historical Sites of Greece
Athens By Night Tour With Folklore Show and Dinner
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Athens Morning Sightseeing Tour With Visit The Acropolis of Athens and New Acropolis Museum


text:
Penny M. Heaton, M.D.
Penny M. Heaton is the chief executive officer of the Bill & Melinda Gates Medical Research Institute (Gates MRI), a non-profit biotechnology organization that applies translational science to combat diseases that disproportionately impact the poor in low- and middle-income countries. Dr. Heaton leads the institute's work to capitalize on new strategies and partnerships to optimize therapeutics, vaccines, and monoclonal antibody candidates; accelerate progress from the lab to the clinic; and develop them through proof of concept in target populations. The mission of the Gates MRI is to advance or develop products that will help eradicate malaria, accelerate the end of the tuberculosis epidemic, prevent diarrheal deaths from occurring in children and improve maternal and neonatal health outcomes. Prior to this role, Dr. Heaton served as director of the Bill & Melinda Gates Foundation's Vaccine Development and Surveillance team, which provided strategic and technical support to the foundation's vaccine development programs against several diseases including HIV, TB, malaria, pneumonia, enteric diseases, and polio.
She has more than 15 years of experience leading vaccine clinical research and development for companies including Novartis, Merck, and Novavax. Dr. Heaton began her career at the U.S. Centers for Disease Control and Prevention conducting diarrheal disease surveillance and investigating outbreaks of foodborne and diarrheal diseases, influencing her life-long passion for vaccine development. Notably, Dr. Heaton co-developed RotaTeq® during her time at Merck & Co., Inc., a rotavirus vaccine which has been licensed in more than 100 countries and universally recommended by the World Health Organization for infants worldwide. A graduate of the University of Louisville School of Medicine in Kentucky, Dr. Heaton is board-certified in pediatrics and pediatric infectious diseases. She is a member of the Pediatric Infectious Diseases Society and a fellow of the American Academy of Pediatrics.


I know, I know, this wasn't announced and some of you may be wondering "Where are the Stirling reviews?". You're right, but in the meantime I spent a wonderful Sunday in Settimo Torinese, near Turin, Italy, with Donato Ciniello and many Extròcosmesi friends, and grabbed my 2/11 Soap and Solid Perfume combo (plus a limited-edition Pirates soap+as combo, which I'll review in the next weeks). I guess I'm biased, here, since Donato is a true friend to me, and I literally love his products (with probably 1-2 exceptions, in a range of almost 30+ soaps), but as soon as I smelled the soap, I instantly knew that another masterpiece was added to my shaving den.
The product comes, at least in the first batch edition, in an elegant glass jar, and it can be considered like a croap, more on the hard side. It's almost black colour is another plus, to me.
Is the description spot on? Absolutely Yes. Is the product as good as it seems? Absolutely YES, YES, YES!!! Q10 and elastin had already been used in another favorite of mine, Extròcosmesi Bay Rum soap, which gave me some of the best shaves with my straight razors, leaving my face as soft as the bottom of a baby.
Very easy to lather with the brush directly on the surface (even with my Simpson Duke 3, which from time to time gives me trouble), the scent literally explodes once the soap is lathered. The cypress is definitely there, as well as the lemon balm, which personally made me think of Captain's Choice Lime AS, while the rosemary is more in the background. Slickness and cushion are great, as almost every Extrò soap, as well as the post-shave feel. It's very difficult to find any con, with products of high level like this.
The matching Solid Perfume is, for now (AS to be expected soon), the logic pairing after the shave. The scent is very close to the soap, personally I find the lemon balm to be more present. Longevity is good, although I wish it was a bit longer. I have to be frank, I prefer the old good classic bottle of AS to this.
Overall, another winner by Donato Ciniello, who is one of the greatest Italian artisans in the Wet Shaving scene.
Available at Extròcosmesi, Settimo Torinese, Italy.
(*) The Good, the Bad and the Ugly by Sergio Leone, 1966.