text:
The addition of paclitaxel to doxorubicin and cisplatin and volume-directed radiation does not improve overall survival (OS) or long-term recurrence-free survival (RFS) in advanced endometrial cancer (EC): A randomized phase III NRG/Gynecologic Oncology Group (GOG) study
Nick M. Spirtos, Danielle Enserro, Howard D. Homesley, Susan K. Gibbons, David Cella, Robert T. Morris, Koen DeGeest, Roger B. Lee, David S. Miller
Objectives: To determine if the addition of paclitaxel (P) to cisplatin and doxorubicin (CD) following surgical debulking and volume-directed radiation therapy improved long-term, recurrence-free survival (RFS) and overall survival (OS) in patients with advanced-stage endometrial cancer (EC). Methods: Prospective, randomized GOG trial comparing (CD) (50 mg/m2)/(45 mg/m2) +/− (P) (160 mg/m2) following volume-directed radiation and surgery in advanced EC. A Kaplan-Meier (KM) analysis characterized the relationship between treatment arms and the OS outcome, a log-rank test assessed the independence of treatment with the OS outcome, and the treatment effect on estimated OS was determined using a Cox proportional hazards (PH) model stratified by stage. The PH assumption was assessed using a test of interaction between treatment variable and the natural logarithm of survival time. Adverse events, regardless of attribution, were graded. Results: Since initial publication, 60 deaths occurred, leaving 311 patients alive with 290 (93.8%) recurrence- free. There was no significant decrease in the risk of recurrence or death associated with the CDP treatment regimen stratified for stage (p = 0.14, one-tail). The exploratory analysis for OS and the corresponding homogeneity tests for different effects across subgroups revealed only EFRT and EFRT & GRD status to have significantly different treatment effects (p = 0.027 and p = 0.017, respectively). Second primary malignancies were identified in 17/253 (6.4%) and 19/263 (7.0%) of patients treated with CD and CDP respectively. Breast (2.4%) followed by colon (1%) were the two cancers most frequently diagnosed in this setting. Conclusion: No significant difference between treatment arms was identified. Subgroup analysis both in the initial and current reports demonstrated a trend towards improved RFS and OS in patients treated with CDP and EFRT. This long-term analysis of outcomes also identified the necessity of providing on-going cancer screening to patients enrolled in trials.
https://doi.org/10.1016/j.ygyno.2019.03.240
Advanced endometrial cancer
Chemotherapy and radiation
Long-term follow-up
Optimal surgery
10.1016/j.ygyno.2019.03.240
Dive into the research topics of 'The addition of paclitaxel to doxorubicin and cisplatin and volume-directed radiation does not improve overall survival (OS) or long-term recurrence-free survival (RFS) in advanced endometrial cancer (EC): A randomized phase III NRG/Gynecologic Oncology Group (GOG) study'. Together they form a unique fingerprint.
Endometrial Neoplasms Medicine & Life Sciences 100%
Paclitaxel Medicine & Life Sciences 98%
Cisplatin Medicine & Life Sciences 87%
Radiation Medicine & Life Sciences 73%
Second Primary Neoplasms Medicine & Life Sciences 13%
Kaplan-Meier Estimate Medicine & Life Sciences 12%
Spirtos, N. M., Enserro, D., Homesley, H. D., Gibbons, S. K., Cella, D., Morris, R. T., DeGeest, K., Lee, R. B., & Miller, D. S. (2019). The addition of paclitaxel to doxorubicin and cisplatin and volume-directed radiation does not improve overall survival (OS) or long-term recurrence-free survival (RFS) in advanced endometrial cancer (EC): A randomized phase III NRG/Gynecologic Oncology Group (GOG) study. Gynecologic oncology, 154(1), 13-21. https://doi.org/10.1016/j.ygyno.2019.03.240
The addition of paclitaxel to doxorubicin and cisplatin and volume-directed radiation does not improve overall survival (OS) or long-term recurrence-free survival (RFS) in advanced endometrial cancer (EC) : A randomized phase III NRG/Gynecologic Oncology Group (GOG) study. / Spirtos, Nick M.; Enserro, Danielle; Homesley, Howard D. et al.
In: Gynecologic oncology, Vol. 154, No. 1, 07.2019, p. 13-21.
Spirtos, NM, Enserro, D, Homesley, HD, Gibbons, SK, Cella, D, Morris, RT, DeGeest, K, Lee, RB & Miller, DS 2019, 'The addition of paclitaxel to doxorubicin and cisplatin and volume-directed radiation does not improve overall survival (OS) or long-term recurrence-free survival (RFS) in advanced endometrial cancer (EC): A randomized phase III NRG/Gynecologic Oncology Group (GOG) study', Gynecologic oncology, vol. 154, no. 1, pp. 13-21. https://doi.org/10.1016/j.ygyno.2019.03.240
Spirtos NM, Enserro D, Homesley HD, Gibbons SK, Cella D, Morris RT et al. The addition of paclitaxel to doxorubicin and cisplatin and volume-directed radiation does not improve overall survival (OS) or long-term recurrence-free survival (RFS) in advanced endometrial cancer (EC): A randomized phase III NRG/Gynecologic Oncology Group (GOG) study. Gynecologic oncology. 2019 Jul;154(1):13-21. doi: 10.1016/j.ygyno.2019.03.240
Spirtos, Nick M. ; Enserro, Danielle ; Homesley, Howard D. et al. / The addition of paclitaxel to doxorubicin and cisplatin and volume-directed radiation does not improve overall survival (OS) or long-term recurrence-free survival (RFS) in advanced endometrial cancer (EC) : A randomized phase III NRG/Gynecologic Oncology Group (GOG) study. In: Gynecologic oncology. 2019 ; Vol. 154, No. 1. pp. 13-21.
@article{4e1640f37ecb4e46aeb0571c90bc755f,
title = "The addition of paclitaxel to doxorubicin and cisplatin and volume-directed radiation does not improve overall survival (OS) or long-term recurrence-free survival (RFS) in advanced endometrial cancer (EC): A randomized phase III NRG/Gynecologic Oncology Group (GOG) study",
abstract = "Objectives: To determine if the addition of paclitaxel (P) to cisplatin and doxorubicin (CD) following surgical debulking and volume-directed radiation therapy improved long-term, recurrence-free survival (RFS) and overall survival (OS) in patients with advanced-stage endometrial cancer (EC). Methods: Prospective, randomized GOG trial comparing (CD) (50 mg/m2)/(45 mg/m2) +/− (P) (160 mg/m2) following volume-directed radiation and surgery in advanced EC. A Kaplan-Meier (KM) analysis characterized the relationship between treatment arms and the OS outcome, a log-rank test assessed the independence of treatment with the OS outcome, and the treatment effect on estimated OS was determined using a Cox proportional hazards (PH) model stratified by stage. The PH assumption was assessed using a test of interaction between treatment variable and the natural logarithm of survival time. Adverse events, regardless of attribution, were graded. Results: Since initial publication, 60 deaths occurred, leaving 311 patients alive with 290 (93.8%) recurrence- free. There was no significant decrease in the risk of recurrence or death associated with the CDP treatment regimen stratified for stage (p = 0.14, one-tail). The exploratory analysis for OS and the corresponding homogeneity tests for different effects across subgroups revealed only EFRT and EFRT & GRD status to have significantly different treatment effects (p = 0.027 and p = 0.017, respectively). Second primary malignancies were identified in 17/253 (6.4%) and 19/263 (7.0%) of patients treated with CD and CDP respectively. Breast (2.4%) followed by colon (1%) were the two cancers most frequently diagnosed in this setting. Conclusion: No significant difference between treatment arms was identified. Subgroup analysis both in the initial and current reports demonstrated a trend towards improved RFS and OS in patients treated with CDP and EFRT. This long-term analysis of outcomes also identified the necessity of providing on-going cancer screening to patients enrolled in trials.",
keywords = "Advanced endometrial cancer, Chemotherapy and radiation, Long-term follow-up, Optimal surgery",
author = "Spirtos, {Nick M.} and Danielle Enserro and Homesley, {Howard D.} and Gibbons, {Susan K.} and David Cella and Morris, {Robert T.} and Koen DeGeest and Lee, {Roger B.} and Miller, {David S.}",
note = "Funding Information: Dr. Danielle Enserro receives money to her institution from NCI for Cooperative Group/NCTN Grant Funding for all aspects of this trial, including travel to Group meetings; statistical analysis, study monitoring, etc. She also receives monies from a NCTN Group Funding Grant through NCI, as well as monies from the GOG Foundation, Inc. Funding Information: This study was supported by National Cancer Institute grants to the Gynecologic Oncology Group (GOG) Administrative Office (CA 27469), the Gynecologic Oncology Group Statistical Office (CA 37517), NRG Oncology (1 U10 CA180822), NRG Operations (U10CA180868) and UG1CA189867 (NCORP). The following Gynecologic Oncology institutions participated in this study: Women's Cancer Center of Nevada, Ohio State University Comprehensive Cancer Center, MD Anderson Cancer Center, University of Iowa Hospitals and Clinics, Tacoma General Hospital, University of Oklahoma Health Sciences Center, University of Minnesota Medical Center-Fairview, University of California Medical Center at Irvine-Orange Campus, Washington University School of Medicine, Case Western Reserve University, Indiana University Hospital/Melvin and Bren Simon Cancer Center, Stony Brook University Medical Center, Walter Reed National Military Medical Center, Gynecologic Oncology Network/Brody School of Medicine, University of Massachusetts Memorial Health Care, University of Kentucky, Ellis Fischel Cancer Center, Cleveland Clinic Foundation, University of Colorado Cancer Center ? Anschutz Cancer Pavilion, Mayo Clinic, University of Mississippi Medical Center, Fred Hutchinson Cancer Research Center, Abramson Cancer Center of the University of Pennsylvania, Albany Medical College, Memorial Sloan Kettering Cancer Center, Abington Memorial Hospital, Duke University Medical Center, Cooper Hospital University Medical Center, ECOG Statistical Center, Wake Forest University Health Sciences, Moffitt Cancer Center and Research Institute, Wayne State University/Karmanos Cancer Institute, University of North Carolina at Chapel Hill, University of Texas Southwestern Medical Center, State University of New York Downstate Medical Center, Roswell Park Comprehensive Cancer Center, University of Cincinnati, Cancer Research for the Ozarks NCORP, Penn State Milton S. Hershey Medical Center, Tufts-New England Medical Center, Community Clinical Oncology Program, Thomas Jefferson University Hospital, Northern Indiana Cancer Research Consortium, University of Virginia, University of Chicago, Fletcher Allen Health Care, Cancer Research Consortium of West Michigan NCORP, University of Alabama at Birmingham, University of Pittsburgh Cancer Institute, University of New Mexico, Fox Chase Cancer Center, Yale University, University of Texas ? Galveston, University of Hawaii, Missouri Valley Cancer Consortium CCOP, Metro-Minnesota CCOP, Geisinger Medical Center and Central Illinois CCOP. Funding Information: Dr. David Miller served as a consultant for Tesaro, Janssen, Clovis and Genentech. His institution also received grant funding through Advenchen, Takeda, Tesaro and Xenetic. He also received monies from Genentech and Clovis for payment for lectures, including service on speakers' bureaus. Publisher Copyright: {\textcopyright} 2019",
doi = "10.1016/j.ygyno.2019.03.240",
journal = "Gynecologic Oncology",
T1 - The addition of paclitaxel to doxorubicin and cisplatin and volume-directed radiation does not improve overall survival (OS) or long-term recurrence-free survival (RFS) in advanced endometrial cancer (EC)
T2 - A randomized phase III NRG/Gynecologic Oncology Group (GOG) study
AU - Spirtos, Nick M.
AU - Enserro, Danielle
AU - Homesley, Howard D.
AU - Gibbons, Susan K.
AU - Cella, David
AU - Morris, Robert T.
AU - DeGeest, Koen
AU - Lee, Roger B.
AU - Miller, David S.
N1 - Funding Information: Dr. Danielle Enserro receives money to her institution from NCI for Cooperative Group/NCTN Grant Funding for all aspects of this trial, including travel to Group meetings; statistical analysis, study monitoring, etc. She also receives monies from a NCTN Group Funding Grant through NCI, as well as monies from the GOG Foundation, Inc. Funding Information: This study was supported by National Cancer Institute grants to the Gynecologic Oncology Group (GOG) Administrative Office (CA 27469), the Gynecologic Oncology Group Statistical Office (CA 37517), NRG Oncology (1 U10 CA180822), NRG Operations (U10CA180868) and UG1CA189867 (NCORP). The following Gynecologic Oncology institutions participated in this study: Women's Cancer Center of Nevada, Ohio State University Comprehensive Cancer Center, MD Anderson Cancer Center, University of Iowa Hospitals and Clinics, Tacoma General Hospital, University of Oklahoma Health Sciences Center, University of Minnesota Medical Center-Fairview, University of California Medical Center at Irvine-Orange Campus, Washington University School of Medicine, Case Western Reserve University, Indiana University Hospital/Melvin and Bren Simon Cancer Center, Stony Brook University Medical Center, Walter Reed National Military Medical Center, Gynecologic Oncology Network/Brody School of Medicine, University of Massachusetts Memorial Health Care, University of Kentucky, Ellis Fischel Cancer Center, Cleveland Clinic Foundation, University of Colorado Cancer Center ? Anschutz Cancer Pavilion, Mayo Clinic, University of Mississippi Medical Center, Fred Hutchinson Cancer Research Center, Abramson Cancer Center of the University of Pennsylvania, Albany Medical College, Memorial Sloan Kettering Cancer Center, Abington Memorial Hospital, Duke University Medical Center, Cooper Hospital University Medical Center, ECOG Statistical Center, Wake Forest University Health Sciences, Moffitt Cancer Center and Research Institute, Wayne State University/Karmanos Cancer Institute, University of North Carolina at Chapel Hill, University of Texas Southwestern Medical Center, State University of New York Downstate Medical Center, Roswell Park Comprehensive Cancer Center, University of Cincinnati, Cancer Research for the Ozarks NCORP, Penn State Milton S. Hershey Medical Center, Tufts-New England Medical Center, Community Clinical Oncology Program, Thomas Jefferson University Hospital, Northern Indiana Cancer Research Consortium, University of Virginia, University of Chicago, Fletcher Allen Health Care, Cancer Research Consortium of West Michigan NCORP, University of Alabama at Birmingham, University of Pittsburgh Cancer Institute, University of New Mexico, Fox Chase Cancer Center, Yale University, University of Texas ? Galveston, University of Hawaii, Missouri Valley Cancer Consortium CCOP, Metro-Minnesota CCOP, Geisinger Medical Center and Central Illinois CCOP. Funding Information: Dr. David Miller served as a consultant for Tesaro, Janssen, Clovis and Genentech. His institution also received grant funding through Advenchen, Takeda, Tesaro and Xenetic. He also received monies from Genentech and Clovis for payment for lectures, including service on speakers' bureaus. Publisher Copyright: © 2019
N2 - Objectives: To determine if the addition of paclitaxel (P) to cisplatin and doxorubicin (CD) following surgical debulking and volume-directed radiation therapy improved long-term, recurrence-free survival (RFS) and overall survival (OS) in patients with advanced-stage endometrial cancer (EC). Methods: Prospective, randomized GOG trial comparing (CD) (50 mg/m2)/(45 mg/m2) +/− (P) (160 mg/m2) following volume-directed radiation and surgery in advanced EC. A Kaplan-Meier (KM) analysis characterized the relationship between treatment arms and the OS outcome, a log-rank test assessed the independence of treatment with the OS outcome, and the treatment effect on estimated OS was determined using a Cox proportional hazards (PH) model stratified by stage. The PH assumption was assessed using a test of interaction between treatment variable and the natural logarithm of survival time. Adverse events, regardless of attribution, were graded. Results: Since initial publication, 60 deaths occurred, leaving 311 patients alive with 290 (93.8%) recurrence- free. There was no significant decrease in the risk of recurrence or death associated with the CDP treatment regimen stratified for stage (p = 0.14, one-tail). The exploratory analysis for OS and the corresponding homogeneity tests for different effects across subgroups revealed only EFRT and EFRT & GRD status to have significantly different treatment effects (p = 0.027 and p = 0.017, respectively). Second primary malignancies were identified in 17/253 (6.4%) and 19/263 (7.0%) of patients treated with CD and CDP respectively. Breast (2.4%) followed by colon (1%) were the two cancers most frequently diagnosed in this setting. Conclusion: No significant difference between treatment arms was identified. Subgroup analysis both in the initial and current reports demonstrated a trend towards improved RFS and OS in patients treated with CDP and EFRT. This long-term analysis of outcomes also identified the necessity of providing on-going cancer screening to patients enrolled in trials.
AB - Objectives: To determine if the addition of paclitaxel (P) to cisplatin and doxorubicin (CD) following surgical debulking and volume-directed radiation therapy improved long-term, recurrence-free survival (RFS) and overall survival (OS) in patients with advanced-stage endometrial cancer (EC). Methods: Prospective, randomized GOG trial comparing (CD) (50 mg/m2)/(45 mg/m2) +/− (P) (160 mg/m2) following volume-directed radiation and surgery in advanced EC. A Kaplan-Meier (KM) analysis characterized the relationship between treatment arms and the OS outcome, a log-rank test assessed the independence of treatment with the OS outcome, and the treatment effect on estimated OS was determined using a Cox proportional hazards (PH) model stratified by stage. The PH assumption was assessed using a test of interaction between treatment variable and the natural logarithm of survival time. Adverse events, regardless of attribution, were graded. Results: Since initial publication, 60 deaths occurred, leaving 311 patients alive with 290 (93.8%) recurrence- free. There was no significant decrease in the risk of recurrence or death associated with the CDP treatment regimen stratified for stage (p = 0.14, one-tail). The exploratory analysis for OS and the corresponding homogeneity tests for different effects across subgroups revealed only EFRT and EFRT & GRD status to have significantly different treatment effects (p = 0.027 and p = 0.017, respectively). Second primary malignancies were identified in 17/253 (6.4%) and 19/263 (7.0%) of patients treated with CD and CDP respectively. Breast (2.4%) followed by colon (1%) were the two cancers most frequently diagnosed in this setting. Conclusion: No significant difference between treatment arms was identified. Subgroup analysis both in the initial and current reports demonstrated a trend towards improved RFS and OS in patients treated with CDP and EFRT. This long-term analysis of outcomes also identified the necessity of providing on-going cancer screening to patients enrolled in trials.
KW - Advanced endometrial cancer
KW - Chemotherapy and radiation
KW - Long-term follow-up
KW - Optimal surgery
U2 - 10.1016/j.ygyno.2019.03.240
DO - 10.1016/j.ygyno.2019.03.240
JO - Gynecologic Oncology
JF - Gynecologic Oncology


text:
Frighteningly Wonderful in Mali
January 29, 2013 January 29, 2013 by Arusha
France's liberation of Timbuktu and defeat of Malian Islamic revolutionaries is right on schedule and demonstrates perfectly the American/French axis routing world terrorism.
Sunday's Meet the Press roundtable was in contrast the perfect example of how fooled and even bamboozled old guard American media personalities still are. Andrea Mitchell excepted, the remaining two old men got almost everything wrong:
Ted Koppel who presided over the creation of the War of Terror in the media predicted "we're entering one of the most dangerous eras this country has ever experienced."
"I think it's even bigger and more troubling than that," pounced Bob Woodward, the man who broke Watergate and was apparently broken by it in return.
I'm making no bones about saying that France's action will be short-lived, especially by the standards of American foreign involvements, and that it will be generally successful. As I said in earlier blogs, I think this is the end-game for the current era of terrorism. That doesn't mean the end to terrorism, of course, just the end of the al-Qaeda chapter.
The end-game wasn't supposed to be quite so publicly bloody, and this is largely because of American missteps in Mali. AFRICOM was the new American African command that set in pace a number of militaristic actions I'm ambivalent about, but which did chase al-Qaeda from Yemen to Somalia to central Africa and finally to North Africa where it was supposed to desiccate in the sand.
This three-year chase fragmented what had been a more structured and organized group of very bad guys. Separately, the Obama drone assassinations took out dozens of terrorist leaders, including of course the Top Gun. Like Sherman plowing through Georgia, death and destruction has been left in the wake, but…
…al-Qaeda is gone, Somalia has been pacified and terrorism has been chased on a long arc from Afghanistan down into east Africa and back up to North Africa … where now the French are pummeling it to death.
It got messy in Mali because Americans don't speak French right. We trained the Malian army and held it up to public scrutiny as a model for modern African armies (allied, of course, to the west).
But those pesky French-speaking Africans got naughty and staged a coup against what we had also championed as one of Africa's most stable democracies, and together with a few other events like generations of weapons released from Libya, the current war was precipitated.
Tuaregs have been fighting for independence since the dawn of the camel, and al-Qaeda remnants fleeing America's silent sweep, pushed north into the southern flowing Libyan arms made uncomfortable but convenient bed fellows. For a while.
It couldn't last. It didn't. But it was strong enough long enough to give the French cause to attack. The French don't dither like Americans. They never have, and their unique forms of morality are the same which continue to celebrate Napoleon's tomb in the Champs de Mars.
North Africa is a mess, but it isn't the global threat that Afghanistan was. The trouble in Egypt is internal and will last for some time, but it will not spread. French foreign legion will be in Mali for some time, now, but fighting will diminish not spread into Niger or Nigeria as old men American commentators claim.
And the terrorism threat will diminish. The world will be more peaceful.
So why am I so unsettled and near sarcastic?
Because this was all planned. I see everything having happened to a a near perfect specific plan, a covert military mission organized by the Obama administration, cleaned up by the French. The French weren't supposed to come out of the rafters, but they had to translate for the Americans. That was the only unplanned move. That this all worked and made the world peaceful is good.
That it is covert and so strikingly successful is terrifying.
Apocalypse Masks Extinctions
Last reply was January 29, 2013
Lynn Werner
View January 29, 2013
Much as you like to imagine this "clean up" by the French – the heroic colonial power sweeping in and saving the day – I beg to differ. First, France was protecting uranium supplies in Algeria on which her power grid depends. No nobility there. I feel that it is naive to think that the colonial powers acting tough fix much of anything. Nothing more than pyrrhic victories. This battle is not over. I do feel that the groups are doing what they do well, moving out and regrouping. Northern Africa is not yet a global threat but one cannot be naive about the deep seated resentment against colonialists by some. Surely there are those who welcome the French. I am pleased, of course, that Timbuktu has been liberated – but that does not mean that there does not continue to be a serious threat. Time will tell. I feel that there are other groups operating and with time there will be more and more revolts against colonialism. I am quite sure that Frances control of substantial Algerian uranium (if what I read is correct), will one day be fodder for revolutionaries who want their resources controlled by Algerians rather than former colonialists. I feel that the internal struggles of Egypt can spread just because of the instability in the region as borders become porous and weapons move more easily. The border between Egypt and Gaza, though not the major issue now, will become porous. US money poured into Egypt is already an issue as we have, unfortunately, sided with Morsi rather than with the secular intellectuals who are now (along with others) trying to create a true democracy… I often don't agree with you… but I am thankful for these blogs, for it sets me reading about the areas you mention. I have not lived in Africa, as you have – but I have been a part of liberation movements in countries whose resources are controlled by other countries, and read from that perspective. There are enormous changes across the globe and though one may feel despair, I think that they are rich with possibility.
Stephen Farrand
Nice story, Jim. Just a couple of points. The French were direct because, as you point out, they're French. We dithered because Obama realized that the last thing we need is another front.
Second, Napoleon's tomb in not in the Champs de Mars. It is in the Cathedrale du Dome in the Hotel National des Invalides located in its own park to the east of the Champ de Mars.
I would be careful not to offend Americans like myself that are/have devoted their lives to conservation efforts.
Your " friend," Naida
Nancy McDaniel
"why are you sarcastic?"
Is that a rhetorical question?
you make some strong accusations re Obama administration. Wonder if you will hear from them
Keith Bates
Great article! The WSJ should know about you. Keith

redpajama_set_name: RedPajamaCommonCrawl


text:
Rolex Announces Young Laureates of 2014 Global Awards Programme
Five young visionaries from Africa, India, Europe and the Middle East were announced today at London's leading scientific institution, the Royal Society, as winners of the 2014 Rolex Awards for Enterprise.
This year's Young Laureates – aged 30 and under – impress by both their leadership qualities and in their ability to harness technology in an original way to improve the well-being of the community and the environment, as well as to advance scientific knowledge.
The five Young Laureates were chosen by an international Jury of eight eminent experts who reviewed a shortlist from among 1,800 applicants from all over the world. The Laureates will each receive 50,000 Swiss francs to advance their projects. They are:
Neeti Kailas, 29, India – aims to vastly increase screening of newborn babies for hearing loss, through an inexpensive, easy-to-use device, and to set up an associated network of health-care professionals in India who can diagnose or treat deafness.
Olivier Nsengimana, 30, Rwanda – is promoting breeding programmes and the release of Rwanda's captive, endangered grey crowned-cranes. The iconic bird, a symbol of wealth and longevity in Rwanda, is a victim of its own beauty, and is often kept as a pet.
Olivier Nsengimana and colleagues put an identification bands on the leg of a Grey Crowned Crane in a hotel in Kigali
Francesco Sauro, 29, Italy – is exploring the vast quartzite caves of South America's fabled tabletop mountains on the border of Venezuela and Brazil, making discoveries of unique worlds that have evolved in isolation over millennia.
Arthur Zang, 26, Cameroon – has invented what is believed to be Africa's first medical tablet, which will allow health-care workers in rural areas to send the results of cardiac tests to heart specialists via a mobile-phone connection.
Hosam Zowawi, 29, Saudi Arabia – is developing rapid tests to detect the presence of antibiotic resistant bacteria, now considered a global threat to human health. He also plans a regional public campaign warning of the dangers of the overuse and misuse of antibiotics.
"After a record number of young applicants this year, we are proud to announce the winners and to support these individuals in developing their inspiring work," said Rebecca Irvin, Head of Philanthropy at Rolex. "The five Young Laureates and their projects clearly demonstrate a strong spirit of enterprise and leadership. This year's Jury was particularly impressed with the practical approach each is taking to solve real-world problems. They are certainly role models whose stories Rolex is pleased to bring to the world."
The Rolex Awards for Enterprise were initiated in 1976 to commemorate the 50th anniversary of the Oyster chronometer, the world's first waterproof watch and a symbol of the innovation that the Awards programme supports. The programme recognizes enterprising men and women who are using their talents and initiative to change the world in five broad areas: science and health, applied technology, the environment, exploration and discovery, and cultural heritage.
In 2010, the first Awards devoted to Young Laureates honoured resourceful young men and women at a critical juncture in their careers. In addition to the prize money, the Young Laureates receive recognition of their projects through an international media campaign, access to the community of former Rolex Laureates and Jury members, and a Rolex chronometer.
The Rolex Awards for Enterprise and the Rolex Mentor and Protégé Arts Initiative, which pairs master artists with emerging talents in seven artistic disciplines for a year-long collaboration, comprise the two major philanthropic programmes of Rolex SA and are run from Rolex headquarters in Geneva.
In this article:african, awards, enterprise, rolex, winners
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text:
DigitalSignalProcessingFilterDesign
===================================

Digital Signal Processing Filter Design

redpajama_set_name: RedPajamaGithub


We want your feedback and feature requests!
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Total Submissions (	54) Approved Submissions (47) Submissions Under Review (7) Submission Closed.
Its a great initiative for spread awareness about road safety. I am very happy to contribute my idea.
In Assam, most of the road accidents are happening because of alcoholic drivers. So I have created a design which is strongly emphasized on drink and drive. Hope you all like it.
ENSURE THE SAFETY OF YOURSELF AND YOUR BELOVED ONES BY OBEYING JUST A FEW SIMPLE RULES. LIVE A SAFETY AND A HAPPY LIFE.
every accident is predictable .but we can avoid it by obeying rules.


← Day 3 traveled to Kavala, Greece which is a port where Paul arrived before going to Philippi.
Lydia of Thyatira is a woman mentioned in the New Testament who is regarded as the first documented convert to Christianity in Europe. A modern outdoor chapel on what is said to be the site where Lydia was baptized.
Acts 16: 11 From Troas we put out to sea and sailed straight for Samothrace, and the next day we went on to Neapolis. 12 From there we traveled to Philippi, a Roman colony and the leading city of that district[a] of Macedonia. And we stayed there several days. 13 On the Sabbath we went outside the city gate to the river, where we expected to find a place of prayer. We sat down and began to speak to the women who had gathered there. 14 One of those listening was a woman from the city of Thyatira named Lydia, a dealer in purple cloth. She was a worshiper of God. The Lord opened her heart to respond to Paul's message. 15 When she and the members of her household were baptized, she invited us to her home. "If you consider me a believer in the Lord," she said, "come and stay at my house." And she persuaded us.
Tree of Life mosaic from the oldest church floors in the world.
Actually it was not. It was more likely a cistern.
A few more ruins after the 4th century. There were no crosses as art before that.
Posted on April 26, 2014, in Uncategorized. Bookmark the permalink.	Leave a comment.


text:
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  session_start();
  $nit_empresa = $_SESSION['usuario']['nit'];
  $id_persona = $_SESSION['usuario']['id_persona'];
  $idEmpresa = $_SESSION['usuario']['id_empresa'];

  require '../conexion.php';

  $data = json_decode(file_get_contents("php://input"));
  if(count($data) > 0)
  {
    $idNumFactura = mysqli_real_escape_string($mysqli, $data->num_factura);
    $idNumDetalle = mysqli_real_escape_string($mysqli, $data->num_detalle);

    $deleteDetalleFactura = "DELETE FROM `detalle` WHERE `detalle`.`num_detalle` = '$idNumDetalle' AND `detalle`.`num_factura` = '$idNumFactura'";
    $deleteFacturaEmpresa = "DELETE FROM `facturaempresa` WHERE `facturaempresa`.`num_factura` = '$idNumDetalle'";

    if(mysqli_query($mysqli, $deleteDetalleFactura))
    {
      if(mysqli_query($mysqli, $deleteFacturaEmpresa))
      {
        echo 'Data Deleted';
      }
    }
    else
    {
       echo "Error al eliminar los datos: " . $mysqli->error;
    }
  }
  else {
    echo "No hay datos para eliminar";
  }

 ?>


2015 has just started, and as you look at yourself in the mirror, you may be unsatisfied with certain parts of your body. Perhaps you've tried dieting and exercising before but were left with the same excess fat in areas like the midsection and thighs. Cosmetic treatments like liposuction and tummy tuck surgery can safely improve these areas of your physique and provide lasting results. However, we've provided some helpful tips that can help you get leaner in the meantime.
Achieving a leaner, more muscular body starts from the inside out. For this reason, your bone health should be at the top of your list. Vitamin D not only keeps your bones strong, but it also helps prevent osteoporosis from developing as you age. The best way to get your daily dose of vitamin D is through a diet that includes eggs, salmon, and fish oil.
While it's been a hotly debated subject for years, there still aren't enough facts to prove whether the fat burning zone does or doesn't exist. Instead of worrying about warming your body up for 20 minutes before beginning your regimen, focus on performing high intensity exercises that begin with and end with a 10-minute cardio cool down.
Studies have proven time and time again that the plateau effect exists. In other words, to burn more fat tissue during your workouts, always strive to increase resistance when possible. This helps to build more muscle and make you stronger in the process of burning fat.
If you are having trouble getting the body you want, we encourage you to call our practice at (301) 220-0400 or fill out our online contact form today. Dr. Carlton Scroggins and his caring staff look forward to hearing from you soon!
This entry was posted on Thursday, February 19th, 2015 at 11:57 pm	and is filed under Healthy Lifestyle. You can follow any responses to this entry through the RSS 2.0 feed. Responses are currently closed, but you can trackback from your own site.


Big Idea: God shows us how to live.
The Ten Commandments: Exodus 19–20, God provides the Ten Commandments to set apart the Israelites as His holy people.
Big Idea: God leads the way.
The people enter the promised land: Joshua 1; 3—4, God appoints Joshua as the new leader of the Israelites and brings His people into the land He'd promised them.
Moses grew in the Lord and was a model of faith to the community. He blessed others and equipped them to live in service to God.
Throughout Exodus and Numbers, Joshua worked closely with Moses. In Exodus 24v13, he is referred to as Moses' aide—his right-hand man.
Joshua was an ideal successor to Moses, and Moses continuously made prophetic hints toward Joshua's future as a leader of God's people.
Read Joshua 1v1–9 just before bedtime. Count with your child how many times God tells Joshua in this part of The Big God Story to "be strong and courageous" (three times). Share with your children that God wants His people to know that He will lead them and they don't have to be afraid. After reading, choose someone in your family to lead everyone to bed. Make sure the leader is creative in the path he takes and the moves he makes in leading everyone off for a good night's sleep.
Why do you think God told Joshua to be "strong and courageous"?
Why didn't Joshua need to be afraid?
How does God lead us every day?
These questions can easily extend into the rest of the week. Look for opportunities to bring conversations about how God Show Us How to Live into your everyday life as a family.
A blessing to pray over your child: (Child's name), may you always listen to the Lord's voice. He will lead the way for you.


text:
03-26-2020 | Blogs, BW News, Intellectual Property
Granting of Waivers by The United States Patent and Trademark Office for Abandoned or Canceled Patent and Trademark Applications
By: David Breiner and Jordan Meggison-Decker
The United States Patent and Trademark Office (USPTO) considers the effects of the Coronavirus outbreak to be an "extraordinary situation." As such, the USPTO has taken steps to reduce certain costs associated with reviving cancelled or abandoned patent and trademark applications.
Filing responses and paying fees associated with patent applications often come with hard deadlines. Failing to timely file a response to a communication from the USPTO or pay a fee can result in the abandonment of a patent application. In the wake of the Coronavirus outbreak, the USPTO has decided to waive certain petition fees associated with reviving abandoned patent applications so long as the abandonment was due to the effects of the Coronavirus. In order to take advantage of this waiver, patent applicants and/or owners must file certain revival papers along with a copy of a memo titled "Relief Available to Patent and Trademark Applicants, Patentees and Trademark Owners Affected by the Coronavirus Outbreak" which is available here. Filing the memo operates as a request for sua sponte waiver of the petition fee. In addition, the patent owner or applicant must file a statement that the delay in filing a reply was because the patent practitioner, applicant, or at least one inventor was personally affected by the Coronavirus outbreak such that they were unable to file a timely reply. The petition to revive the abandoned application must occur either: 1) within two months after a notice of abandonment has been mailed; or 2) six months after the date the application became abandoned. Please note similar waivers are available for terminated reexamination proceedings.
As for trademarks, the USPTO decided to waive petition fees (set by regulation rather than statute) for applications and registrations that were abandoned, canceled, or expired due to the inability to timely respond to a trademark-related communication from the USPTO as a result of the Coronavirus outbreak. When reviving an abandoned, canceled, or expired trademark application or registration, the applicant must file a statement explaining how the failure to respond to the communication from the USPTO was due to the effects of the Coronavirus outbreak. The petition must also be filed not later than two months after the issue date of the notice of abandonment or cancellation. If the applicant or registrant did not receive a notice of abandonment or cancellation, the petition must be filed not later than six months after the date the trademark electronic records system indicates that the application is abandoned or the registration is cancelled/expired.
The USPTO is certainly mindful of its customers and we are happy to see them take such affirmative steps to help them through these trying times. BrownWinick has a specialized group of intellectual property attorneys who routinely interface with the USPTO and can certainly help you with these and other matters. Don't hesitate to ask us for help!


Despite some ease-of-use issues, this program helps you put a different face on your PC anytime you want. Wallpaper Cycler organizes your various wallpapers in categories, which the program will then cycle through at specified times. You can import any of your own images directly into the program, or create custom designs with the built-in gradient tool. You'll also find a list of links to popular image sites for obtaining even more shots to use as wallpapers. Operating this program wasn't the easiest thing we've ever done, as it takes a while to get the hang of where all the controls are and what they do. The Layout feature, which lets you create your collages from several different pieces of wallpaper, is a nice touch, but you'll definitely want to consult the help manual to grasp its possibilities. Still, folks who like to frequently change their wallpaper might find this program worth the time it takes to overcome the learning curve.
Wallpaper Cycler is an easy to use, yet powerful desktop wallpaper manager and changer to get rid of that boring static wallpaper on your desktop. You can change the wallpaper with a specific delay or at specific times. Wallpapers are easily managed in multi-level categories which can have time constraints to give your desktop a time or season dependent look. Tags can be used to link wallpapers to specific layouts and to create search folders. Tags can also be used in combination with the Smart Orientation feature to select portrait/landscape wallpapers when your monitor is in portrait/landscape mode. The powerful layout feature allows you to create custom layouts for your desktop which enable you to show an unlimited combination of calendars, quotes, notes, webcams, other wallpapers, calendar notes objects, and news (RSS) headlines. Any combination of effects (blur, brightness, color-tone, mask, and textures) can be applied to each individual object.
Version 3.6.0.180 may include unspecified updates, enhancements, or bug fixes.
Greatest Wallpaper Cycler ever it is very custmisiable its possibilities is endless.
I recommend it very highly if you like to see your 10 000 photo set cycling on wallpaper. I have not found a better programme yet.


Spanish economic growth has been very positive throughout the last decade, at least unemployment hasn't increased, and our ratio of public debt to GDP has stayed constant at 100% since 2014. What it should be done will be to use this epoch of positive economic performance to reduce finally and once for all, the Spanish eternal deficit, which this time positions itself around 3% of GDP. The government is basing its socialist budget on the assumption that an economic growth rate of around 3.5% will generate extra fiscal revenue of 12,000 million. These assumptions are no more than fairy tales. There is no time for austerity, because austerity should be a permanent policy.
Public expenditure will be boosted unnecessarily in some areas, as the government has raised wages of public workers by 3%, while it has eliminated IRPF (income tax) for workers earning between 12,000 and 18,000 euros per year, while lowering also VAT over the cinema industry. Slashing taxes is always a matter of joy, and as I have previously said, tax decreases will always benefit the economy in one way or another but reducing taxes or even eliminating them for 3.5 million citizens while increasing public expenditure affecting nearly the same volume of the population are not economics or fiscal policy…it is populism, pure socialist populism.
Many people ask me when they hear me criticize so harshly the new national budget why shouldn't we have an expansionary budget. Firstly, because in my opinion eliminating our deficit should be the first function of the government before providing any other kinds of expenditure. The Spanish passive positions itself on 100% over GDP since 2014, while countries as Luxembourg or Ireland have reduced their debt by 50% or 60% in that same time period.
Normally people I've talked to seem really happy by an increase of pensions of around 4%, mainly by deviating funds from the central State down to the Social Security program, which we should remember has got already a debt hole of 20,000 million euros.
What the government doesn't want to assume is that their Welfare State is bankrupt and the system should be rethought severely, as for example by shifting the pension system from a public defined-contribution to a mixed or even capitalization system similar to Holland's or Chile's, as I already commented in previous articles in this site. What should be crystalline clear is that transferring funds to a debt blackhole is not even a short-term solution… it is political propaganda. Once again, pure populism.
Thirdly I would like to explain in depth why this budget is solely new electoral populism. If we look at the main goals of this national budget, and quoting Cristobal Montoro, "This budget is designed for public workers and pensionists". I don't know if Mr. Montoro thinks we are stupid or what, but this phrase represents nonsense. If we look at poverty rates in Spain we'll see that jubilees have a rate of risk of poverty situated near 10%, the second lowest one in Spain after fixed workers (in which all public workers are taken into account) , which have a rate of risk of poverty of just 5%, and no public worker will be taken into account in this 5%, as wages are fixed by the public administrations and not according to productivity, which discards the option of having salaries lower than the risk of poverty threshold, which is around 8,200 euros per person a year.
So, if the budget was really designed to help the needed or the poor; as has been claimed throughout all these years, the national budget will present greater expenditure for unemployed people or autonomous workers, which have a rate of poverty risk of 47% and 28% respectively. This is not a redistribution of wealth, this is not solidarity, this is just an electoral propaganda weapon used by the right wing of this country trying to gain the vote of the majority and living aside the minority, as pensionists represent 6.7 million people along with public workers which are 3.1 million, forming a total of 9.8 million people, which is nearly a 20% of the Spanish population. Mariano is basically buying votes!
Finally, the enormous fiscal pressure in Spain is constantly falling over the citizenship and displacing hundreds of millions from private hands, which could use this money in an efficient and productive way. Politicians are constantly extracting valuable resources from the population and wasting them with electoral ends. They have created their own system to perpetuate themselves in power. It is a complete Ponzi scheme which should be broken down by a further liberalization of the economy through several reductions in taxes. The time for bureaucrats has ended, now is time for liberty.


Hey! This is just a quick post. I had a lot of fun last night! Today we might go skiing since there's actually some snow here, but I don't know. I've never been skiing, snowboarding or anything. Is that weird? Most likely weird. Hopefully I don't look crazy stupid.
I still need to order the rest of my textbooks. I only ordered one. I looked online and nearly all of my professors want "custom books". These are books where the professor asks the publisher to take different chapters out of different book and put it in a custom hard cover. These are super expensive, you can't buy them used, and you can't sell them when you're done. UGH!!! That's also another thing I'll be doing today, trying to buy those without having a heart attack.
Anyways, I love all things nautical, and I just wanted to show you guys some pictures I found on Pinterest that I love.
Blah…I hate when they do that. Or when they publish their own books. And make you buy them. Skiing is soooo much fun. I found skiing easier than snowboarding. It takes a minute to pick up, but once you've got your bearings it's not too hard at all! Have a ton of fun!
I also love all things nautical!!
If nautical nonsense is something you wish, then jump on the deck and flop like a fish.
Ahh..love the pics! Cant wait for summer to go sailing!
I love the water & adore nautical themes!! Makes me want summer now!
Thanks everyone. I'm in the summer mood just a little too much.
have fun!!!! we love skiing.


LIVERPOOL edged past Leeds in the Carling Cup last night courtesy of a David Ngog goal which handed them a 1-0 win.
League One Leeds, who had not faced Liverpool for over five years, put on a spirited display of attacking that had Rafa Benitez nervously eyeing Steven Gerrard and Fernando Torres on the bench.
Leeds had the ball in the net after 11 minutes but the goal was disallowed when the linesman harshly flagged Luciano Becchio offside as he helped the ball home.
Elsewhere, there was a big result for Portsmouth, winless in the league, who beat Carlisle 3-1. Newcastle's kids, though, were soundly beaten 2-0 at Peterborough.
Arsenal got the better of West Brom 2-0, while Sunderland saw off Birmingham 2-0.


text:
https://www.theheraldreview.com/local-news/article/Marching-towards-the-Crossroads-14358993.php
Marching towards the Crossroads
Sarah Neubecker
Published 5:01 pm EDT, Tuesday, August 14, 2012
FAMILY CELEBRATION: The Great American Crossroads Celebration will be held Aug. 15 to 18, beginning with the Miss Reed City/Prince Pageant. The weekend will include softball tournaments, a fashion show and a parade, and will draw around 1,000 people to the area. (Herald Review file photo) less
FAMILY CELEBRATION: The Great American Crossroads Celebration will be held Aug. 15 to 18, beginning with the Miss Reed City/Prince Pageant. The weekend will include softball tournaments, a fashion show and a ... more
Reed City prepares for annual summer festival
REED CITY – The eighth annual Great American Crossroads Celebration kicks off today in Reed City, attracting friends, family and tourists to the "crossroads of Michigan" for a four-day festival packed with activities. The festival, which runs today to Sunday offers a variety of events each day, spread from Westerburg Park to Babb Ford to downtown Reed City. "There will be a lot of activity and things going on," said Suzie Williams, executive director of the Reed City Area Chamber of Commerce. "It's a fun time for people to be out and about." Some of the Crossroads Festival events include:
Wednesday Miss Reed City/Prince Pageant, 6:30 to 8 p.m. at G.T. Norman Elementary School, sponsored by the Reed City GFWC;
Thursday Fashion show, 5 to 7 p.m. at Westerburg Park, sponsored by Nica's Boutique and Head to Toe Salon and Spa; Teen dance, 8 to 11 p.m. at Westerburg Park, sponsored by the Reed City High School Class of 2016; Friday Quilt show, 10 a.m. to 5 p.m., Trinity Lutheran School gym; Festival Parade, 6 p.m. in downtown Reed City, sponsored by Cuttin' Loose; Softball Tournament begins, 6 to 10 p.m., sponsored by the Great American Crossroads Celebration Committee; Teen talent show, 7 to 9 p.m. at the Reed City High School cafeteria, sponsored by Osceola Coalition to Reduce Underage Drinking; Music by DJ Wessen, 10 p.m. to 1 a.m. in the beverage tent at Westerburg Park;
Saturday Pancake breakfast, 8 to 11 a.m. at the Reed City Fire Department, sponsored by the Reed City Fire Department; 5k run, 9 a.m. at Spectrum Health Reed City Hospital, sponsored by Mosiac; Car show, 9 a.m. to 2 p.m. on Upton Avenue between Chestnut and Higbee streets, sponsored by St. Philip Neri Catholic Church; Rock Wall, 10 a.m. to 3 p.m. at Babb Ford, sponsored by Eagle Village; Lucky Duck race, noon at the Mini-Mack bridge in Linear Park, sponsored by Big Brothers/Big Sisters; World's Slowest Bike Race, 1 to 2 p.m. on Howard Street near the entry to Rambadt Park, sponsored by Together We Can! Sunday Softball tournaments end, 7 a.m. to 4 p.m., sponsored by the Great American Crossroads Celebration Committee. From new events, to popular favorites Williams estimates the festival will bring more than 1,000 people – alumni, friends and newcomers – to Reed City for a few days. "People come home and visit their family," Williams said. "They come to the beverage tent and see all the people they used to know. A lot of reunions happen." Most events at the festival are free to the public. For more information on the festival's other activities – which include kids inflatables, cage fighting, softball tournaments, a chicken barbecue, live music and other fun-filled events – visit www.reedcity.org/great-american-crossroads-celebration.html .


Macvean Videography | I feel so lucky to have her….
I feel so lucky to have her….
Devon & James are a wonderful couple, full of fun and humour, they were married in the stunning Holdsworth House, Halifax. Its quiant homely charm was the perfect backdrop for their celebrations and whilst the weather was fine, the interior surroundings were just as beautiful as the well kept gardens.


text:
Q: @android:id/list cannot resolve symbol

import android.app.ListFragment;
import android.os.Bundle;
import android.view.LayoutInflater;
import android.view.View;
import android.view.ViewGroup;
import android.widget.AdapterView;
import android.widget.ArrayAdapter;

/**
 * Created by name on 3/13/17.
 * Used for the specials tab to allow a list of days to choose what special one would like to view
 */

public class SpecialsScroll extends ListFragment implements AdapterView.OnItemClickListener{
    public SpecialsScroll(){
        //Empty Constructor
    }
    @Override
    public View onCreateView(LayoutInflater inflater, ViewGroup container, Bundle savedInstanceState){
        super.onCreate(savedInstanceState);
        return inflater.inflate(R.layout.fragment_specials_scroll, container, false);
    }
    @Override
    public void onActivityCreated(Bundle savedInstanceState){
        super.onActivityCreated(savedInstanceState);
        setListAdapter(ArrayAdapter.createFromResource(getActivity(), R.array.days, android.R.layout.simple_list_item_1)); //Loads array into the ListFragment
        getListView().setOnItemClickListener(this); //activates the listener for this Fragment class
    }
    @Override
    public void onItemClick(AdapterView<?> parent, View view, int position, long id){ // For checking when a user taps on an option
        SpecialsPage specialsPage = new SpecialsPage();
        Bundle foodArgs = new Bundle();
        switch (position){ // checks what option is chosen and sends respective keys as parameters
            case 0:
                int[] keysMonday = {R.string.boom_boom_enchiladas_key, R.string.tacos_mexican_key};
                foodArgs.putIntArray("keys", keysMonday);
                break;
            case 1:
                int[] keysTuesday = {R.string.shrimp_avocado_tacos_key, R.string.green_chile_chicken_enchiladas_key};
                foodArgs.putIntArray("keys", keysTuesday);
                break;
        }
        specialsPage.setArguments(foodArgs);
        getActivity().getFragmentManager().beginTransaction().replace(R.id.container, specialsPage).addToBackStack(null).commit();
    }
}

import android.os.Bundle;
import android.support.annotation.NonNull;
import android.support.design.widget.BottomNavigationView;
import android.support.v7.app.AppCompatActivity;
import android.view.MenuItem;

public class MainActivity extends AppCompatActivity{

    private BottomNavigationView.OnNavigationItemSelectedListener mOnNavigationItemSelectedListener
            = new BottomNavigationView.OnNavigationItemSelectedListener() {

        @Override
        public boolean onNavigationItemSelected(@NonNull MenuItem item) {
            if(getFragmentManager().findFragmentByTag("CURRENT") == null){
                getFragmentManager().beginTransaction().add(R.id.container, new SpecialsScroll(), "CURRENT").commit();
            }
            switch (item.getItemId()) {
                case R.id.special:
                    getFragmentManager().beginTransaction().replace(R.id.container, new SpecialsScroll(), "CURRENT").commit();
                    return true;
                case R.id.locations:
                    getFragmentManager().beginTransaction().replace(R.id.container, new LocationsScroll(), "CURRENT").commit();
                    return true;
                case R.id.order:

                    return true;
            }
            return false;
        }

    };
    @Override
    protected void onCreate(Bundle savedInstanceState) {
        super.onCreate(savedInstanceState);
        setContentView(R.layout.activity_main);

        BottomNavigationView navigation = (BottomNavigationView) findViewById(R.id.navigation);
        navigation.setOnNavigationItemSelectedListener(mOnNavigationItemSelectedListener);
        getFragmentManager().beginTransaction().add(R.id.container, new SpecialsScroll(), "CURRENT").commit();

    }
}

So, I am trying to create a ListView and everything in the code works, but suddenly I am unable to get the xml to recognize the android:id/list attribute for some reason, I don't know why. When I click on an item in the listview in my app it still does what it should, I just really want to get rid of the error.

<?xml version="1.0" encoding="utf-8"?>
<LinearLayout
    xmlns:android="http://schemas.android.com/apk/res/android"
    android:orientation="vertical"
    android:layout_width="match_parent"
    android:layout_height="match_parent"
    android:background="@color/white">
    <ListView
        android:id="@android:id/list"
        android:layout_width="match_parent"
        android:layout_height="match_parent">

    </ListView>
    <TextView
        android:id="@+id/text_specialsscroll"
        android:layout_width="match_parent"
        android:layout_height="match_parent" />

</LinearLayout>

04-26 14:06:30.299 2576-2576
/com.namename.www.name
E/AndroidRuntime: FATAL EXCEPTION: main
  Process: com.namename.www.name, PID: 2576
                                                                                java.lang.RuntimeException: Unable to start activity ComponentInfo{com.namename.www.name/com.namename.www.name.MainActivity}: java.lang.RuntimeException: Content has view with id attribute 'android.R.id.list' that is not a ListView class
                                                                                at android.app.ActivityThread.performLaunchActivity(ActivityThread.java:2665)
                                                                                at android.app.ActivityThread.handleLaunchActivity(ActivityThread.java:2726)
                                                                                at android.app.ActivityThread.-wrap12(ActivityThread.java)
                                                                                at android.app.ActivityThread$H.handleMessage(ActivityThread.java:1477)
                                                                                at android.os.Handler.dispatchMessage(Handler.java:102)
                                                                                at android.os.Looper.loop(Looper.java:154)
                                                                                at android.app.ActivityThread.main(ActivityThread.java:6119)
                                                                                at java.lang.reflect.Method.invoke(Native Method)
                                                                                at com.android.internal.os.ZygoteInit$MethodAndArgsCaller.run(ZygoteInit.java:886)
                                                                                at com.android.internal.os.ZygoteInit.main(ZygoteInit.java:776)
                                                                                Caused by: java.lang.RuntimeException: Content has view with id attribute 'android.R.id.list' that is not a ListView class
                                                                                at android.app.ListFragment.ensureList(ListFragment.java:402)
                                                                                at android.app.ListFragment.onViewCreated(ListFragment.java:203)
                                                                                at android.app.FragmentManagerImpl.moveToState(FragmentManager.java:1010)
                                                                                at android.app.FragmentManagerImpl.moveToState(FragmentManager.java:1171)
                                                                                at android.app.BackStackRecord.run(BackStackRecord.java:816)
                                                                                at android.app.FragmentManagerImpl.execPendingActions(FragmentManager.java:1578)
                                                                                at android.app.FragmentController.execPendingActions(FragmentController.java:371)
                                                                                at android.app.Activity.performStart(Activity.java:6695)
                                                                                at android.app.ActivityThread.performLaunchActivity(ActivityThread.java:2628)
                                                                                at android.app.ActivityThread.handleLaunchActivity(ActivityThread.java:2726)
                                                                                at android.app.ActivityThread.-wrap12(ActivityThread.java)
                                                                                at android.app.ActivityThread$H.handleMessage(ActivityThread.java:1477)
                                                                                at android.os.Handler.dispatchMessage(Handler.java:102)
                                                                                at android.os.Looper.loop(Looper.java:154)
                                                                                at android.app.ActivityThread.main(ActivityThread.java:6119)
                                                                                at java.lang.reflect.Method.invoke(Native Method)
                                                                                at com.android.internal.os.ZygoteInit$MethodAndArgsCaller.run(ZygoteInit.java:886)
                                                                                at com.android.internal.os.ZygoteInit.main(ZygoteInit.java:776)

A: Change your id to this:
 <ListView
        android:id="@+id/list"
        android:layout_width="match_parent"
        android:layout_height="match_parent">

    </ListView>

redpajama_set_name: RedPajamaStackExchange


text:
Q: How to restart apache2 when I get a pid conflict and php not processed by the server There are processes named 'apache2' running which do not match y our pid file which are left untouched in the name of safety, Please review the s ituation by hand.
Following Test Were Done
no of pids -> sudo pidof apache2
3501 3500 3498 3497
Remove 3497 id and sudo service apache2 start - >
Error:
 * Starting web server apache2                                                    *
 * The apache2 configtest failed.

Output of config test was:
apache2: Syntax error on line 140 of /etc/apache2/apache2.conf: Syntax error on line 1 of /etc/apache2/mods-enabled/authz_default.load: Cannot load /usr/lib/apache2/modules/mod_authz_default.so into server: /usr/lib/apache2/modules/mod_authz_default.so: cannot open shared object file: No such file or directory
Action 'configtest' failed.

The Apache error log may have more information.
Need your assist ....
even php not processed in the server

A: php 5.5 not compatible with precise64 version..so I tried with trusty64 all work fine..


text:
Illustration by Nick Vokey
By Diana Crow
Molecular biology tells us that even the simplest cells are confoundingly complex and that to understand them, scientists must experiment on and observe cells. But the subfield of synthetic biology counters: what if the best way to understand cells is to just build them from scratch?
Science historian and anthropologist Sophia Roosth spent nearly a decade observing and interviewing self-declared synthetic biologists, a loosely defined cohort of engineers, scientists, and citizens who design and build artificial organisms.
Today synthetic biology undergirds applications in many fields, including pharmaceuticals, agriculture, and biofuels and other chemicals. Investors are pouring more than $1 billion into synthetic biology companies each year. But Roosth began her fieldwork in an earlier phase, at MIT in the mid-2000s. That led her into conversations with biohackers, electrical-engineers-turned-microbe-designers, leaders of pharma startups, scientific "copyleft" advocates, and distinguished biologists who hope to "resurrect" extinct species through 21st century biotechnology. Though their goals and methods are diverse, Roosth noticed several common threads—especially that synthetic biologists try to "know" the biological world by designing and constructing new lifeforms.
Genomes that have evolved in nature over millions of years are full of overlapping sequences, incomplete remnants of old genes, and long stretches of DNA with no discernable purpose. Synthetic biologists eschew that messiness; their organisms are made to fit the synthetic biologist's purposes and aesthetics. In most synbio operations, any artificial organisms that don't fit the mold are discarded. For Roosth, that raised a question: What ideas, assumptions, and goals do synthetic biologists bring to this work?
Roosth, a professor at Harvard, distilled her observations into an anthology-like book called Synthetic: How Life Got Made, and I called her to find out more. Here are a few of the highlights, edited for length and clarity.
Going back to the beginning, why write an ethnography of synthetic biologists?
I was curious about a few things. One was: How is bioengineering being harnessed both for design projects and as a kind of pedagogical tool? And I was interested in this democratization of engineering. What does it mean to have undergraduate students designing organisms?
The people were coming from electrical engineering, computer science, among other fields. What I noticed was that moving from a home discipline like electrical engineering into synthetic biology, people were also importing certain metaphors and ways of thinking.
Can you give an example?
When Drew Endy [now a Stanford professor] was a grad student, he sought to build a computational model that would predict the behavior of the bacteriophage T7. Now, the phage is a really simple, well-characterized entity. It's been studied in labs for 60 years, and it doesn't do that much.
But the computational model was a very poor predictor of T7's behavior. And while it might seem common sense to some people that that meant there was something wrong with the model, he instead inferred that there was something wrong with the virus.
That [raised] a series of questions both for him and for his colleagues about what it would mean for a biological entity to be well-designed. And what it meant for it to be well designed, [Endy decided], was for it to be comprehensible, that is understandable to humans. Which is a radically different definition of what counts as good design.
You say in your book that synthetic biologists are complicating our definitions of lineage and related-ness. How so?
The question that arises when you look at an engineered microbe — say, a bacteria that contains lots of different genes from very diverse species is: how do you then place that on any kind of taxonomic tree or lineage?
Some people would actually cite the way that model has broken down in recent years because of the increasing research about lateral gene transfer [which is when microbes swap genes among themselves]. Bioengineering is considered by some synthetic biologists to be a difference of degree but not of kind from what nature does on its own, which is mix lots of different genes together.
In the final chapter, you discuss the "de-extinction movement," which proposes to resurrect extinct species through bioengineering. How does the de-extinction movement connect to the rest of synthetic biology, and how is it different?
I think the de-extinction movement is the most extreme, media-genic version of synthetic biology.
Efforts to "resurrect" extinct species involve cobbling together lots of different genetic material. For example, the woolly mammoth project includes several key genes that were sequenced from woolly mammoth tissue, but those would be ported into an elephant genome. So then the question is: when is something really a woolly mammoth and when is it just sort of a fancy elephant with tusks and really thick hair?
When I asked de-extinction biologists this question … the answer was, "Well, if it looks enough like that extinct species, then it is that [species]."
Which brings us back to the bacteriophage: when is it a successful design project? Well, if it's able to infect bacteria, then that's a good phage. If it's easier to understand, then it's a good phage. Perhaps you could say something similar about passenger pigeons and woolly mammoths.
Late in the book, you make a point about synthetic biology becoming more "normal," at least in terms of how the public perceives it. What does that trend mean to you?
A nice earlier example of this is recombinant DNA research. Recombinant DNA was considered to be a huge deal in the 1970s with regard to ethics and the ontology of what was being made, and now it's something that's done in most biology labs without even thinking twice about it.
That's why I thought it was important to write this book now, because it's much more interesting to track these formations, biological and cultural formations, when they're still remarkable and while they're still up for debate. Because once they cease to be remarkable, we cease to ask important questions about them.
It's Time to Believe in Synthetic Biology
By Diana Crow on Aug. 31, 2017
In "The Runaway Species," Anthony Brandt and David Eagleman try to unlock the secrets of creativity. by Michael Hawley


There's a lot that happens between eying the subject and getting the results. This is extremely complex to describe and understand. Luckily, the technological advancements have taken this burden off the photographer's shoulder. However there's quite a lot which still only the photographer can do, after all there's a difference between the man and the machine.
Composition is one such thing. While today's digital cameras can focus and expose effectively and some even do the face-recognition, it is only the human eye which can visualize the results and perceive the effect or the final result perhaps. Composition is the effective placement of the visual elements in the photographic frame such that the results draw emotional reaction.
There are various elements that contribute to a good composition like the color, texture, lines, shapes, the light and more. Also there are various rules which works more as guidelines to help you use these elements for maximum effect. Here are commonly used rules and elements contributing in making eye-catching photographs.
One of the most crucial element of making great photographs is the composition and you can make good composition by following the rule of thirds. The rule of thirds in the photographic composition speaks about the placement of the subject in the third part of the frame — where the photographic plane is divided into three equal parts either vertically, horizontally or diagonally.
You can make your compositions aesthetic and pleasing by following the golden rule. The golden rule or the golden ratio is about placing various elements of a photograph off-center; by placing them in the ratio of 1:1.61803399. The golden ratio is best used when composing a scene comprised of two major contrasting planes; by placing the planes vertically, horizontally or diagonally in the golden proportion.
Lines draw the viewer's eye in the photograph and draws his attention to your center of interest. Portraying the lines as the subject conveys orientation, elegance, strength and authority. Lines also play an important role when used in conjunction with the subject — by complementing the subject harmoniously.
Patterns add interest to the composition. Patterns draw the viewer's eye and engages the user in the myth of voluminous repetitions. Patterns help in creating illusionary effects; and thus heighten the sense of involvement into the dynamics of the subject. Patterns are a perfect medium of portraying the blend of colors, shades, tones and conveying the effects of lines, curves and textures.
Perspective is all about portraying your creative outlook and viewpoint of the subject. Your perspective adds an element of interest in the photograph. It adds depth in your photographs; by introducing the third dimension to plain, dull and flat photographic plane. You can portray your perspective by including elements in the foreground, depicting converging lines and most important by experimenting with various angles of shooting. The angle of shooting helps in exploring and discovering the dimensions and dynamics of the subject.
Natural frames compliment the subject by drawing the viewer's eye to your center of interest. You can weave the story around your composition by following natural framing tips. Complimenting your subjects with the natural frames add your unique perspective to the composition.
Though the above mentioned rules and elements add to the interest, creativity and uniqueness of the composition; you can always include people, expressions, kids & pets, magic lights, motion effects and blurred backgrounds to make the compositions lively and dominating.
As I noted earlier, composition is out of reach of the camera and is dependent on the perception and the visualization of the photographer. Good composition is the difference between a perfectly sharp and well exposed yet uninteresting photograph and an underexposed photo with effective highlight on specific area(s) of the frame that make it interesting even to the layman.
Still not sure how to make impressive images. Check out the killer composition tips to make a mark with your photographs.
Thanks for sharing these tips. bookmarked and printed :) really interesting and helpful!


"To blindly trust government is to automatically vest it with excessive power. To distrust government is simply to trust humanity - to trust in the ability of average people to peacefully, productively coexist without some official policing their every move. The State is merely another human institution - less creative than Microsoft, less reliable than Federal Express, less responsible than the average farmer husbanding his land, and less prudent than the average citizen spending his own paycheck."


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NewsTech
FCC Proposal Could Punish International Robocallers
byJames Walker	on July 3, 2019
The FCC and U.S. Congress are in the process of working out new rules to get rid of robocalls forever. In the meantime, there are some solutions that could work in the short-term. One such solution may be arriving in a few weeks' time. A new proposal from the FCC will allow the agency to target scam calls that originate abroad or that use other evasive methods to get around spoofing laws.
As a continuation of Ray Baum's Act, which was adopted last year, this rule isn't brand new. It is another piece that bolsters the Truth in Caller ID Act.
The Truth in Caller ID Act bans the spoofing of numbers, a method that makes robocalling very easy, but it only applies to calls that originate in the U.S. This was a scammers dream come true as it opened a huge loophole for them to make international calls. The Ray Baum's Act changes those rules to prohibit international spoofing specifically, along with robocalling techniques that use VoIP and other modern infrastructures.
The problem is that just because something has been made illegal, it doesn't mean that the FCC can go after those committing the crimes. If the agency's official rules say nothing about how to locate and take action against people who have violated the law, it won't have any power to do so. This new rule has been created to do just that.
The proposal by FCC Chairman, Ajit Pai, will be released to the public later this week and will be voted on during a FCC open meeting, held on August 1st. If the new rule is adopted, the agency would be able to go after robocallers abroad, just as they are able to do with robocallers located in the U.S.
It goes without saying that tracking down scammy robocallers in a foreign nation, that may not be very friendly toward the US, is very different that catching domestic operations and fining them. An FCC official explaining the new rules on a press call described the operations as extremely complex, with many involving multiple shell companies and sophisticated obfuscation methods.
Up until this point, many robocallers may have been justifiably operating on an assumption that they were immune to being pursued by U.S. authorities. The moment these scammers are no longer guaranteed impunity, they may deem it an unnecessary risk to continue their operations. Some scammers may simply cut and run with the money they've already made and move on to the next scheme that has lower risk.
When it comes to more long-term solutions, phone carriers are working on the implementation of a new system that would better block robocalls. But there is some concern that carriers won't enable this service by default or that they may charge customers to use it.
Robocalling is a problem that is growing by the year. There is no perfect solution, but pervasive efforts to crack down on these scams, no matter their origin, is a step in the right direction.
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The #1 platform to read the latest Tech news, reviews, trends and more. From the latest gadget reviews to the hottest tips and tricks for social media influencers, if it's to do with Technology you can bet we'll talk about it. To learn more about us, click here.
byJeff J	on July 12, 2019
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I help solve business problems for some of the world's most admired brands. My work has been recognized by The Addy Awards, The One Show, The Webby Awards, SEGD, Creative Review, and Communication Arts.
I have 12+ years of experience designing innovative digital products and services for the world's most admired brands. My work has been recognized by the One Show, Webbys, SEGD, Creative Review, and Communication Arts.
Previously I was a Senior Product Designer at R/GA.
An Experience Designer based in NYC.
I help solve problems for some of the world's most admired brands. Recently I have contributed to projects that have won awards from the ADDYs, One Club, and the Webbys.
Currently I'm a Vice President, Creative Director building the next big thing at Digitas New York.
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We are a team of dedicated, proactive and trained crew to ensure excellent cleaning and maintenance for our valued clients. The equipment used by our team had been carefully selected to meet the needs of the job. Our crew had been trained in techniques and methods to carry out the cleaning process and equipment handling for best results.
We offer Facilities Management that covers all organisational functions that improve and provide better working, healthcare, education & training undertakings.
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There are two ranges in our Pets catalogue: the PROFESSIONAL range and the SPORT range.
The PROFESSIONAL range is sold exclusively through veterinary surgeons and pharmacies, and includes internationally renowned brands such as GLYCO-FLEX, one of the most widely used chondroprotective agents throughout the world; MalAcetic, TrIzEDTA, KlearOtic, CUTANIA and LimePlus, the choice for dermatology; ALYSIA, VIRAMAX and DURALACTIN Lysine, three products to control Feline Herpes Virus, and pioneering and market leaders in Spain and Portugal; the DIALIX range that comprises six products for urology; and the VTB product range, the first bone tissue bank in Europe for orthopaedic transplants.
A key product in the SPORT range is RED CELL Canine, which is a leading product in Spain, and for maximising the sporting performance of sledge dogs, dog agility, greyhounds, hunting dogs, show dogs, etc. and to combat anaemic conditions. The rest of the range comprises hygiene products, fly, mosquito and tick control etc.; and antiseptics and the PDI range, the world's largest manufacturer of antiseptic/disinfectant wipes. The range is available through veterinary surgeons and pet shops, supermarkets, gunsmiths, etc..
Thank you for helping to improve our product catalogue, distribution network, service quality…If you have any suggestions, please let us know via the suggestions box that follows, we will value them greatly, thank you very much.


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Identification of Highly Active Fe Sites in (Ni,Fe)OOH for Electrocatalytic Water Splitting
Operando XAS showing structural changes at Fe dopants in Ni(OH)2/NiOOH host structure. Ni(OH)2 is oxidized into γ-NiOOH under OER operating conditions, inducing significant M–O bond contraction at both Ni and Fe sites. Theoretical modeling of site specific OER overpotentials using DFT+U reveals the origin of enhanced OER activity in Fe-doped γ-NiOOH, in which Fe sites have near-optimum binding energies for OER intermediates.
The conversion of solar energy and water to hydrogen is a key element to a renewable fuel infrastructure, in which such "renewable hydrogen" can be utilized in fuel cells for electric vehicles, or as reducing agent for the upgrading of biomass to hydrocarbon fuels or, ultimately, for the direct reduction of CO2 to fuels. The bottleneck for the efficiency of electrochemical and photoelectrochemical water splitting is the high overpotential required for the anodic half-reaction, the oxygen evolution reaction (OER). In contrast to many other catalytic reactions, e.g. in fuel cells, where thorough fundamental understanding of the interactions at the atomic scale that determine catalytic activity and catalyst stability in a corrosive environment has been achieved, such understanding, which could lead to breakthrough discoveries of new materials with significantly enhanced catalytic performance, is still lacking for the OER.
Recently, a team of researchers at the Joint Center for Artificial Photosynthesis (JCAP), SUNCAT, and the Stanford Synchrotron Radiation Lightsource (SSRL) investigated mixed Fe/Ni oxyhydroxide films, which are among the most active known catalysts based on earth-abundant elements for the OER in alkaline electrolytes. While it was known that the mixed Fe/Ni compounds exhibit up to 3 orders of magnitude higher OER activity than the pure Fe and Ni parent compounds, the origin of this enhancement was subject to speculation. The new study, which was published in Journal of the American Chemical Society, reveals the structure of Fe/Ni catalysts in their operating state during OER, and provides evidence for the first time on the nature of the active site, which is a Fe surface atom surrounded by neighboring Ni sites. This finding is in contrast to widely held views, according to which Ni, not Fe had been proposed to constitute the active sites in the mixed material.
Operando x-ray absorption spectroscopy (XAS) using the advanced x-ray spectrometer at SSRL Beam Line 6-2 indicated that for Fe contents up to ~25%, all Fe atoms substitute for Ni sites to form, under OER conditions, a Fe3+-containing Ni3+,4+ oxyhydroxide with unusually short Fe–O bond lengths. Using this knowledge of the structure of the operating catalyst, theoretical modeling of OER overpotentials was performed to gain insight into the origin of catalytic enhancement. DFT+U calculations, in which both Ni and Fe were tested as catalytic sites, reveal as a general trend that adsorbed OER intermediates become less stable at both sites in mixed materials compared to pure NiOOH and FeOOH. The energetics of the intermediates are thereby shifted further away from the optimum condition at Ni sites, while near-optimal energetics are achieved at Fe sites that have Ni neighbors.
Primary Citation:
D. Friebel, M. W. Louie, M. Bajdich, K. E. Sanwald, Y. Cai, A. M. Wise, M.-J. Cheng, D. Sokaras, T.-C. Weng, R. Alonso-Mori, R. C. Davis, J. R. Bargar, J. K. Nørskov, A. Nilsson and A. T. Bell, "Identification of Highly Active Fe Sites in (Ni,Fe)OOH for Electrocatalytic Water Splitting", J. Am. Chem. Soc. 137, 1305 (2015), DOI: 10.1021/ja511559d.
Daniel Friebel, SUNCAT
Alexis T. Bell, JCAP
electrocath20.pdf
Read: Lay Summary
>>Read more science highlights


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Tax Policy Office
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The Tax Policy Office helps the Governor, legislators, legislative committees, local and tribal governments, industries, public interest groups and taxpayers understand the New Mexico tax system and any proposed changes to it. The Office supports this effort by producing numerous annual publications on tax program guidance, tax statutes, rules and regulations, and tax research. The Office develops, analyzes and presents tax proposals for the Department, the Governor and the Legislature.
The Tax Policy Office consists of three areas: the Tax Information and Policy Office; the Tax Analysis, Research and Statistics Office; and the local Government Liaison.
Mark Chaiken
Director of Tax Policy
Mark.Chaiken@tax.nm.gov
Mark has over twenty-five years of legal experience, more than fifteen of which have been spent in taxation and public finance. He has a B.A. from Haverford College in Pennsylvania, his J.D. is from Rutgers School of Law, Newark, and he has an LL.M. in Taxation from New York University School of Law.
The Tax Policy office is responsible for resolving policy issues, supplying information, including bulletins and FYI publications, about the various tax programs to taxpayers, legislators, and government agencies, drafting regulations, responding to requests for tax rulings, and performing economic analysis of existing and proposed legislation.
As Tax Policy Director, Mark's emphasis is on updating and streamlining tax regulations, ensuring consistency in interpretation of tax law, and providing clear and prompt advice to taxpayers in a complex and fast-changing state tax environment.
Tax Information and Policy Office
The Tax Information and Policy Office provides information and guidance on New Mexico taxes through publications (bulletins, brochures, FYI's and forms), regulations and responses to ruling requests and general inquiries. To contact the Tax Information and Policy Office you can email policy.office@tax.nm.gov.
The office maintains 349 publications on tax-reporting rules, processes, and incentives. Forms and publications can be located on the Department's website here:
Forms Publications
During legislative sessions, the Office reviews all introduced bills, assigns those dealing with taxation or motor vehicles for further review throughout the Department and disseminates Fiscal Impact Reports. After legislative sessions, the Office assists with the implementation of new legislation.
The Office also manages the process for creating regulations and handles all ruling requests. For more information on how to request a ruling, please see:
Tax Analysis, Research and Statistics Office
Chief Economist Lucinda Sydow can be contacted by email at Lucinda.Sydow2@tax.nm.gov.
The Tax Analysis, Research and Statistics Office consists of a team of economists providing fiscal and policy analyses and statistics about the New Mexico tax system. The office develops data sets, models, methods, and research to support sound tax policy and forecasting. Annual publications include the Tax Expenditure Report, which along with additional publicly available information are posted on the Department's website here:
The economists are members of the consensus revenue estimating group (CREG), which forecasts state general fund revenues. The revenue forecast is a critical element of the process of proposing and enacting the state budget each year.
During legislative sessions, the Office also prepares a Fiscal Impact Report on each bill that affects revenues administered by TRD.
Much of the data used by these economists are subject to confidentiality laws (IRS Publication 1075; USC Title 26, IRC 6103; NMSA 7-1-8 et.al.). In accordance with NMSA 7-1-8.3, information that may be revealed to the public is posted on the Department's website at the following locations:
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Requests for information for the purpose of tax research may be made to Tax.Research@tax.nm.gov
The Department will make every effort to fulfill information requests, if not otherwise prohibited by law.
Local Government Liaison David Monteith can be reached by email at:
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The local government liaison works closely with local and tribal governments to implement new tax rates and agreements with the Department.


Cervical spondylopathy is a spinal disorder of large and giant breeds of dogs, such as Great Danes and Doberman Pinschers. Various underlying disorders of the neck bones cause the condition, including partial dislocation (subluxation) of vertebrae, deformed vertebrae, cartilage and ligament defects, and abnormally small openings in the vertebrae. The origin of these defects is unknown, but the net result is compression (squeezing) of the spinal cord and mild to severe spinal cord problems. Some cases may be due to diets too rich in protein, energy, calcium or phosphorus.
"Wobbler syndrome" is a term used to describe disorders involving compression of the cervical spinal cord (the portion of the spinal cord located in the neck) in large- and giant-breed dogs. Basically two types of compressive disease are included: 1) disk-related disease in mature dogs with thickening of the ligaments and instability of the joints between the cervical vertebrae (bones of the neck) and 2) disease of the cervical vertebrae in young dogs resulting from developmental abnormalities which cause malformation of the cervical spine. Another name for wobbler syndrome is "cervical vertebral instability."
The causes of wobbler syndrome include cervical intervertebral disk disease, abnormalities of the cervical vertebrae, and malformation of the cervical vertebrae due to poor nutrition. Large, fast-growing dogs are at risk for vertebral-related disease.
Clinical signs vary widely depending on the amount of spinal cord compression caused by the cervical vertebral instability. Signs may have a rapid and sudden onset or they may progress slowly. The signs may or may not worsen. The dog may have neck pain, difficulty rising to a standing posture, wasting of the muscles (especially in the forelimbs), worn toenails, unsteady gait, and general difficulty in maintaining normal postures.
The veterinarian will obtain a medical history and perform physical and neurological examinations. The breed of dog is important in suggesting a diagnosis of wobbler syndrome. This syndrome is reported in large- and giant-breed dogs, especially in older Doberman pinschers and young Great Danes. If wobbler syndrome is suspected, the veterinarian will perform additional tests. Diagnosis is made through radiographs (X-rays) of the spinal column. Myelograms (special contrast X-rays) may be needed to evaluate the spinal cord. Additionally, an analysis of the cerebrospinal fluid may be performed. Cerebrospinal fluid is obtained by inserting a needle into the spine and withdrawing fluid.
How is wobbler syndrome treated?
The treatment for wobbler syndrome is determined by the age of the dog, the type of cervical instability, and the severity of clinical signs. The dog's activity is restricted. For growing dogs with vertebral related disease, the veterinarian may discontinue excessive use of dietary supplements (if these have been used) and may control food intake. Neurological (relating to the nervous system) problems may continue. In these dogs, the veterinarian will try to stop the progression of the disease. Physical therapy usually is required to help the pet regain lost function. Generally these dogs are surgical candidates. Surgical procedures may include decompression of the spinal cord, fenestration to attempt to prevent other disks from causing disease, and stabilization or fusion of the spine. Some veterinary surgeons and neurologists consider fusion of the vertebrae to try to stabilize the spine controversial. The use of steroids in combination with surgery is usually the most effective treatment. The use of steroids alone is helpful only in mildly affected patients.
What is the prognosis for dogs with wobbler syndrome?
The prognosis (outcome) for dogs with wobbler syndrome is variable. The earlier in the course of disease that surgery is performed, the better the outcome. Paralysis is always a possibility in dogs with wobbler syndrome; frequently these dogs cannot be helped.
1. Surgical relief of spinal cord compression and/or surgical stabilization of affected vertebrae is the best treatment for cervical spondylopathy. Without surgery, most cases recur and eventually become worse. This surgery is one that we will almost always refer you to a surgical specialist to perform.
2. Rest and anti-inflammatory drugs can help the condition, but unless surgery is done, cases treated medically usually recur.
3. Your pet's surgeon will instruct you in home care after surgery. If we can be of assistance during the recovery period we will be happy to as needed.
* Signs recur after apparent recovery.


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You are here: Home > 58:04 Ken Burns on National Parks - Ken Burns and Dayton Duncan their six-part PBS documentary series The National Parks: America's Best Idea. The film is the story of an idea as uniquely American as the Declaration of Independence.
58:04 Ken Burns on National Parks – Ken Burns and Dayton Duncan their six-part PBS documentary series The National Parks: America's Best Idea. The film is the story of an idea as uniquely American as the Declaration of Independence.
https://www.youtube.com/watch?v=4gT6Hnb0_V4
58:04 Ken Burns on National Parks – Ken Burns and Dayton Duncan their six-part PBS documentary series The National Parks: America's Best Idea. The film is the story of an idea as uniquely American as the Declaration of Independence and just as radical — that the most special places in the nation should be preserved, not for royalty or the rich, but for everyone.
See also – https://www.youtube.com/watch?v=Qz-2PRvXoe8 –
Silver Sliver Studios subscribers
A feature documentary that explores the beautiful Washington State. We invite viewers on an epic journey through three national parks and one volcanic monument. Mount Rainier, Mount St. Helens, Olympic, and the North Cascades deliver some of the most breathtaking sights in the world.
Music by: Derek Palmer
audiojungle.net/user/palmtreep
Chapter Selection:
Mt. Rainier – 2:37
Mt. St. Helens – 18:51
Olympic – 23:37
North Cascades – 42:26
#MtRainier
#MtStHelens
#OlympicNationalPark
#NorthCascades