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Tolerability, Pharmacokinetics, and Serum Bactericidal Activity of Intravenous Dalbavancin in Healthy Volunteers
Anton Leighton, Alice Bendix Gottlieb, Mary Beth Dorr, Daniela Jabes, Giorgio Mosconi, Claudia VanSaders, Edward J. Mroszczak, Kathleen C. M. Campbell, Ellen Kelly
Anton Leighton
1Vicuron Pharmaceuticals, Inc., King of Prussia, Pennsylvania 19406
Alice Bendix Gottlieb
3Clinical Research Center, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 08903
Mary Beth Dorr
Daniela Jabes
2Vicuron Pharmaceuticals, 21040 Gerenzano (Varese), Italy
For correspondence: djabes@vicuron.it
Giorgio Mosconi
Claudia VanSaders
Edward J. Mroszczak
Kathleen C. M. Campbell
4Southern Illinois University School of Medicine, Springfield, Illinois 62794
Ellen Kelly
5Center for Speech and Hearing Sciences, East Brunswick, New Jersey 08816
Fifty-two healthy adult male and female volunteers were enrolled in this double-blind study to determine the maximum tolerated dose, characterize the pharmacokinetics, and obtain serum bactericidal activity (SBA) data for intravenous dalbavancin. Subjects were assigned to single- or multiple-dose groups and randomized to receive dalbavancin or placebo intravenously over 30 min. Doses started at 140 mg in the single-dose group and with a 300-mg loading dose (LD), followed by six daily 30-mg maintenance doses (MDs), in the multiple-dose cohort and escalated to a 1,120-mg single dose and a 1,000-mg LD and 100-mg MD regimen. Plasma, urine, and skin blister fluid aspirate drug concentrations were measured, and pharmacokinetic parameters were determined via noncompartmental methods. SBA against methicillin-resistant Staphylococcus aureus (MRSA) was determined at several time points. Adverse events and changes from the baseline for laboratory data, electrocardiograms, audiologic assessments, physical examinations, and vital signs were assessed. Concentrations increased in proportion to the dose. Steady-state concentrations were achieved by day 3 with the 10:1 LD-MD regimen. The half-life averaged 181 h, and the mean volume of distribution and clearance were 9.75 liters and 0.0473 liters/h, respectively. Mean values were similar in all groups and in males and females. The portion of the dose excreted renally averaged 33.5%. Bactericidal activity was demonstrated in serum at 7 days in all subjects receiving single doses of ≥500 mg. All doses were well tolerated. Dose-limiting toxicity was not encountered. No changes in auditory or vestibular function occurred. The long half-life and maintenance of SBA against MRSA for 1 week suggest that weekly dosing may be feasible.
Nosocomial infections with multiple-drug-resistant organisms such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci, and penicillin-resistant Streptococcus pneumoniae pose a particular challenge to clinicians. An increase in the incidence of serious infections caused by resistant gram-positive organisms (4, 8, 11) has led to the need for new antibiotics with activity against these pathogens.
Dalbavancin (also known as BI 397) is a novel semisynthetic glycopeptide antibiotic obtained by chemical modification of a natural glycopeptide (A40926). Although dalbavancin has the same mechanism of action as vancomycin (7), some vancomycin-resistant enterococci (3) and staphylococci with intermediate sensitivity to glycopeptides (C. J. Hackbarth, S. Lopez, G. Romano, A. Malabarba, J. Trias, and R. White, Abstr. 39th Intersci. Conf. Antimicrob. Agents Chemother., abstr. 1283, 1999) remain sensitive to dalbavancin.
Dalbavancin has demonstrated in vitro activity against more than 6,000 strains of gram-positive bacteria (3, 5, 6, 10a). The minimum concentration that inhibited 90% of the isolates (MIC90) ranged from 0.06 to 0.5 mg/ml for methicillin-sensitive S. aureus, MRSA, and coagulase-negative staphylococci and from 0.03 to 0.13 mg/ml for streptococci. Dalbavancin is also active against several anaerobic gram-positive bacteria, including Clostridium sp., Peptostreptococcus sp., and Actinomyces sp. Dalbavancin is also active against Corynebacterium sp. and Bacillus subtilis. The MICs of dalbavancin against staphylococci are generally lower than those of vancomycin, teicoplanin (3), linezolid (10a), and quinupristin-dalfopristin (6). Several immunocompetent and immunocompromised animal infection models have demonstrated the in vivo efficacy of dalbavancin (3). As expected, dalbavancin is not active against most gram-negative species (6).
An initial phase 1, randomized, double-blind, single- and multiple-dose escalation study was conducted with 23 normal male subjects (R. J. White, G. L. Brown, M. Cavaleri, and G. Romano, Abstr. 40th Intersci. Conf. Antimicrob. Agents Chemother., abstr. 2196, 2000). Levels of dalbavancin in plasma showed dose-related increases following administration of single (70, 140, 220, and 360 mg) and multiple (70-mg daily dose for 7 days) intravenous doses of dalbavancin. The 24-h trough values following multiple-dose administration showed an approximately fivefold increase from day 1 to day 7. The terminal half-life (t1/2) of dalbavancin ranged from 123 to 210 h. Dalbavancin was well tolerated, as evidenced by no clinically significant changes in vital signs, electrocardiogram (ECG), or laboratory assessments during the 28-day follow-up period.
The present study was conducted to further assess the safety and tolerance of intravenous dalbavancin administration following administration of single and multiple doses in healthy volunteers and to establish the maximum tolerated dose. Additionally, the serum bactericidal activity (SBA) against two strains of MRSA was determined.
(These data were presented in part at the 41st Interscience Conference on Antimicrobial Agents Chemotherapy, Chicago, Ill., 16 to 19 December 2001 [Abstr. 41st Intersci. Conf. Antimicrob. Agents Chemother., abstr. A-951 and A-2192, 2001].)
This study was conducted from September 2000 to May 2001 at the Clinical Research Center, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey. The protocol was approved by the Institutional Review Board of the Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey. Each subject gave witnessed, written informed consent prior to undergoing any study procedures.
Selection of subjectsHealthy males or females between 18 and 55 years of age were eligible for enrollment. All subjects had to be surgically sterile, postmenopausal (female), or using effective contraception. Each subject had to have a normal audiologic assessment at baseline. Subjects were excluded for significant prior or current exposure to aminoglycoside antibiotics, chemotherapeutic agents, loop diuretics, and need for over-the-counter, herbal, or prescription medications during the study. Clinically significant laboratory, ECG, or physical assessment abnormalities on pretherapy screening tests also precluded participation in this study.
Study designThis was a phase 1, randomized, double-blind, placebo-controlled, single- and multiple-dose dose escalation study of dalbavancin administered as a 30-min intravenous infusion to healthy subjects. Fasting was not required, and there were no dietary restrictions. Subjects were assigned to either a single- or multiple-dose group and then block randomized to receive either placebo (one per group) or dalbavancin (three per group). The study drug was administered intravenously once in the single-dose cohort and daily for 7 days in the multiple-dose cohort.
The dose of dalbavancin given to the single-dose groups was 140, 350, 500, 630, 840, or 1,120 mg. Pharmacokinetic modeling based on data from an earlier phase 1 study was used to design loading dose (LD) and maintenance dose (MD) regimens for the multiple-dose groups to rapidly achieve steady-state concentrations. It was calculated that an LD/MD ratio of 10:1 would be optimal. Subjects were administered the LD as two equal doses separated by 12 h (e.g., 150 mg at 8 a.m. and at 8 p.m. for the 300-mg LD). The dose regimens given in the multiple-dose groups were 300 and 30, 400 and 40, 600 and 60, 800 and 80, and 1,000 and 100 mg.
Doses were escalated via a modified Fibonacci series (10) starting with 140 mg in the single-dose cohort, and the 300- and 30-mg regimen in the multiple-dose cohort. The investigator could proceed to the next dose level if dose-limiting toxicity was not reported. Dose-limiting toxicity was defined as any drug-related adverse event (AE) occurring in two or more subjects that was scored as grade 2 or greater according to the World Health Organization toxicity grading scale.
Blood sampling and analytical methodIn the single-dose cohort, blood samples were collected immediately prior to administration of the dose, at the end of the infusion, and at 1, 2, 4, 6, 12, 18, 24, 48, 72, 96, 120, 144, 312, 480, and 648 h after the start of the infusion. In the multiple-dose cohort, blood samples were collected at baseline, at the end of the first infusion, 1 and 6 h after the start of the first infusion, 30 min and immediately prior to the start of the second infusion, at the end of the second infusion, and 1 and 6 h after the start of the second infusion; on days 2 through 7, blood samples were collected immediately prior to the daily infusion and at the end of the infusion; on day 7, additional blood samples were collected at 1, 6, 12, 24, 72, 120, 144, 312, 480, and 648 h after the final infusion.
Urine was quantitatively collected for the first 24 h in all single- and multiple-dose groups and for 24 h after the last infusion in the multiple-dose cohort. Random urine samples were also collected on days 4, 7, 14, 21, and 28 in single- and multiple-dose groups and on day 35 in the multiple-dose cohort.
Blister fluid was collected at several time points from two subjects, one in the 1,120-mg group and one in the 800- and 80-mg group. To produce a blister, a cantharadin plaster solution (0.7%) was applied to the forearm. The solution was rinsed off within 4 to 6 h or as soon as a blister formed.
Plasma, blister fluid, and urine samples were stored at −20°C or below until analysis for dalbavancin concentrations. Concentrations were measured by high-performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry detection. The plasma and urine assays had a lower limit of quantitation of 0.5 mg/liter. The intraday variability of the plasma assay as measured by the percent relative standard deviation (standard deviation/mean · 100) of quality control samples was 3.77 to 8.82%, and the interday variability was 2.37 to 11.7%. The corresponding values for the urine assay were 4.38 to 9.62% and 4.20 to 13.9%. Blister aspirates were quantitated with the plasma assay.
Pharmacokinetic calculationsDalbavancin plasma pharmacokinetic data were analyzed by noncompartmental methods with WinNonlin (standard version 1.1; Pharsight Corporation, Mountain View, Calif.) and the model for a constant intravenous infusion dose. The pharmacokinetic parameters calculated for the single-dose groups were Cmax (maximum concentration observed), Tmax (time at which Cmax occurred), AUC (total area under the plasma concentration-time curve), t1/2, CL (plasma clearance), and Vss (volume of distribution at steady state). For the multiple-dose groups, Cmax, Tmax, Cmin (trough plasma concentration at 24 h following administration of the last dose), and Tmin were recorded from the observed data on day 1. On day 7, the steady-state Cmax, Tmax, and Cmin were also obtained by visual inspection of the concentration-versus-time curve; AUC0-24 (24-h AUC), t1/2, and CL (MD/AUC0-24) were calculated.
Renal clearance (CLR) was calculated as the amount of dalbavancin excreted into urine through the 24-h period divided by the corresponding day 1 or day 7 AUC0-24 for the single- and multiple-dose groups, respectively. Quantitative excretion of dalbavancin into urine was calculated as the ratio of CLR/CL × 100. All urine pharmacokinetic calculations were carried out with Excel (version 7.0; Microsoft Corporation, Redmond, Wash.).
Statistical analysis of the pharmacokinetic data included descriptive statistics calculated with WinNonlin and Excel and linear regression analysis performed with Sigma Plot (SPSS, Inc., Chicago, Ill.). Linear regression analysis was carried out for Cmax and AUC versus dose (single doses) and steady-state Cmin and AUC0-24 versus dose (multiple doses) to test for dose proportionality. Because of the small sample size, inferential statistical comparisons were not performed.
SBAIn all groups, blood samples were collected at 24 (day 2), 48 (day 3), and 144 (day 7) h relative to the start of the single infusion (single-dose cohort) or final infusion (multiple-dose cohorts) for SBA testing.
S. aureus 3886 and 3897, both methicillin resistant (methicillin MIC, 128 mg/liter), were used as test organisms. The dalbavancin MICs for these strains were 0.13 and 0.25 mg/liter, respectively. The dalbavancin minimum bactericidal concentration (MBC) was equal to the MIC. Tests were performed in accordance with National Committee for Clinical Laboratory Standards recommendations (9). Heat-inactivated pooled human serum (CELLect, lot. no. R10738) was used as a diluent for the serum samples. The absence of antimicrobial activity in human serum against the test strains was previously verified.
Twofold serial dilutions of the test samples in human serum were prepared in microtiter plates. For each strain, exponentially growing cultures were diluted to 106 CFU/ml in Mueller-Hinton broth (Difco, Detroit, Mich.) supplemented with Mg2+ and Ca2+, and 50 μl of the bacterial suspension was distributed into each well to give a final bacterial concentration of 5 × 105 CFU/ml. All experiments were conducted in triplicate on three different days. Plates were incubated at 35°C for 24 h. Two aliquots, 10 μl each, were withdrawn from the wells that did not show visible growth and subcultured on Todd-Hewitt agar (Difco, Detroit, Mich.). A possible antibiotic carryover effect was reduced by plating three 10-fold dilutions of each sample. A colony count was performed after 48 h of incubation at 35°C. SBA was defined as the highest dilution of each sample that reduced the initial inoculum by ≥99.9%.
Safety assessmentsAssessments for AEs were performed throughout the duration of the study and were graded by the investigator as mild, moderate, severe, or life threatening and in accordance with the World Health Organization toxicity grading system (e.g., any body temperature of >37.1°C was reported as pyrexia). The investigator was also asked to categorize the events in regard to their relationship to the study drug. Laboratory data (chemistry panel, blood count with differential, and urinalysis) were collected on days 4 and 7 for all groups and additionally on days 2, 10, and 14 in the multiple-dose groups. Laboratory values were assessed for changes from the baseline; out-of-range values were also identified. ECGs were performed on day 3 in the single-dose groups and on days 3 and 7 in the multiple-dose groups, and changes from the baseline were assessed. All postbaseline ECGs were reviewed in a blinded fashion against the corresponding baseline ECG by an independent reviewer.
Audiologic assessments were conducted at the baseline and on days 2, 7, and 14 in the single-dose groups and on days 2, 7, 14, and 21 in the multiple-dose groups. The audiologic methods used in this study were in accordance with the guidelines of the American Speech-Language Hearing Association (1) and are detailed in a separate publication (2).
PatientsFifty-two subjects were enrolled; 39 received dalbavancin, and 13 received placebo. The majority were Caucasian (n = 25) or Black (n = 19). The subjects were between 19 and 52 years of age (mean of 28.1 years), and roughly half (n = 25) were male. Their heights ranged from 152.4 to 190.5 cm (mean, 169 cm), and their weights ranged from 48.1 to 104.3 kg (mean, 71.3 kg). Fifty-one subjects completed the study; one subject in the dalbavancin 800- and 80-mg group voluntarily withdrew on day 1. Pharmacokinetic parameters from this subject were included in the day 1 mean values.
PharmacokineticsMean dalbavancin plasma concentration-time profiles for the single- and multiple-dose cohorts are shown in Fig. 1 and 2, respectively. Mean dalbavancin concentrations in plasma increased proportionally with dose and declined in a log-linear manner in the terminal portion of the profile.
Mean dalbavancin concentrations in plasma following administration of single 30-min intravenous infusion doses (n = 3 per group).
Mean dalbavancin concentrations in plasma following administration of multiple 30-min intravenous infusion doses (n = 3 per group).
Mean dalbavancin pharmacokinetic parameters are shown in Table 1 for the single-dose groups and in Table 2 for the multiple-dose groups. In all groups, Cmax was observed following completion of the intravenous infusion. The mean t1/2 of dalbavancin ranged from 149 to 198 h, was similar in the single- and multiple-dose cohorts, and showed no tendency to change with the dose. In the single-dose cohort, the mean CL and Vss were also similar across all dose levels. The dalbavancin CLR was lower than the CL and ranged from 0.0115 to 0.0228 liters/h. The proportion of dalbavancin excreted unchanged in the urine ranged from 25.0 to 45.5% of the administered dose. Pharmacokinetic parameters showed low intersubject variability on the basis of the percent relative standard deviation calculated across all subjects in the single-dose cohort: t1/2, 11.0%; CL, 12.7%; Vss, 20.1%. With the multiple-dose regimens, steady-state concentrations were generally achieved on day 2 or 3 following administration of the initial dose. Dalbavancin blister fluid concentrations correlated well with simultaneously obtained drug levels in plasma. The ratio of the concentration in blister fluid to the concentration in plasma ranged from 0.83 to 1.11. Urine concentrations were above the limit of quantitation of the assay (0.5 mg/liter) at all times measured through 28 days postdose.
Dalbavancin pharmacokinetic parameters following administration of a single 30-min intravenous infusion to healthy male and female subjectsa
Dalbavancin pharmacokinetic parameters following administration of multiple daily 30-min intravenous infusions to healthy male and female subjectsa
The dalbavancin Cmax increased in proportion to the increase in the dose in subjects receiving single doses. AUCs showed a similar linear relationship to the dose increment (Fig. 3). Linear regression analyses of Cmax and AUC versus the dose administered demonstrated a linear relationship, with correlation coefficients of 0.930 and 0.944, respectively.
Linear regression analysis of dalbavancin AUC versus dose following administration of single 30-min intravenous infusion doses of 140 to 1,120 mg.
Although this study was not designed to compare dalbavancin pharmacokinetics between male and female subjects, an evaluation of t1/2,Vss, and CL values from the single-dose cohort was performed. The mean t1/2s were similar for the two genders (172 h for males and 169 h for females). Mean Vss and CL values were 13% higher in males, but after correction for body weight, these parameters were found to be similar in males and females.
SBAThe MIC and MBC of dalbavancin against the two MRSA test strains with 50% human serum were determined as the internal control for each experiment. The MIC and MBC in the presence of 50% human serum were 1.71 and 2.04 mg/liter, respectively, for the 3886 strain and 1.22 and 1.61 mg/liter, respectively, for the 3897 strain. Samples from all subjects treated with single doses of ≥500 mg, and from all subjects receiving multiple doses, showed bactericidal activity against both MRSA strains through 7 days after dalbavancin administration. The median reciprocal SBA titer for the 3886 strain and the corresponding plasma concentration data for all of the time points studied are shown in Fig. 4. Reciprocal SBA titers increased with drug concentrations in plasma. All samples in which the corresponding drug concentrations in plasma exceeded 20 mg/liter had a detectable bactericidal titer.
Reciprocal SBA titer against a strain of MRSA versus corresponding dalbavancin concentration.
Safety and tolerabilityThere were no serious AEs or deaths reported in this study. No dose effects were seen for AEs or laboratory values. Sixty-seven percent of the subjects reported at least one treatment-emergent AE. Most AEs were mild in severity, and none met the criteria for dose-limiting toxicity. The most common AEs in both the single- and multiple-dose groups were pyrexia (50%), headache (25%), and nausea (6%). Subjects receiving placebo also reported pyrexia (38%) and headache (31%). Pyrexia was defined, in accordance with World Health Organization toxicity grading criteria, as any oral temperature of >37.1°C; no subject had a temperature exceeding 37.5°C at any time during the study. There were no clinically significant changes from the baseline regarding laboratory findings, vital signs, physical examinations, or ECGs. Mild (less than five times the upper limit of normal), transient, asymptomatic elevations in alanine aminotransferase and aspartate aminotransferase were observed in one subject who received 350 mg of dalbavancin and in no subjects who received higher doses. One dalbavancin-treated subject experienced a transient hyperglycemia (blood glucose level of 160 mg/dl) that was considered mild, and one subject in the placebo group also experienced mild hyperglycemia (135 mg of glucose/dl).
Results of audiologic assessments were published in detail elsewhere (2). Overall, these assessments showed no audiologic changes in any subject. Analysis of variance results indicated that there was no significant change over time related to treatment condition or stimulus frequency. The power to detect a change, if it had occurred, was >0.99.
Tolerability, pharmacokinetic, and pharmacodynamic data from 51 subjects were analyzed in this phase 1, double-blind, randomized, placebo-controlled, single- and multiple-dose dose escalation study.
Dalbavancin was well tolerated at all of the doses studied, including a single dose of 1,120 mg and multiple doses of 1,000 mg on the first day, followed by 100 mg daily for an additional 6 days (1,600-mg total exposure). The most frequently reported treatment-emergent AEs in both dalbavancin-treated and placebo-treated patients were pyrexia (temperature range, 37.1 to 37.5°C) and headache. There was no relationship between the incidence or severity of AEs and the dose of dalbavancin administered and no difference in the incidence of AEs between the dalbavancin and placebo groups. No AEs met the criteria for dose-limiting toxicity.
In the absence of protocol-defined dose-limiting toxicity, additional dose escalation of dalbavancin could have proceeded in the present study. The study concluded with dose levels of 1,120 mg as a single dose and 1,000 and 100 mg as a multiple-dose regimen because the dalbavancin concentrations in plasma achieved with these doses exceeded the concentrations expected to be required for clinical use.
This study used well-designed, carefully standardized, and tightly controlled audiologic assessments with statistical power exceeding 0.99. No significant changes occurred with any audiologic test for any individual subject or when analyzed by group.
Mean pharmacokinetic parameters found in the present study were similar to those obtained in a previous study (White et al., 40th ICAAC). In single- and multiple-dose cohorts, the dalbavancin Cmax and AUC increased in proportion to the dose given while the t1/2, CL, and Vss remained essentially unchanged. Accordingly, dalbavancin demonstrated linear, dose-proportional pharmacokinetics. The 10:1 LD-to-MD ratio achieved the desired objective, as a steady state was achieved as early as 2 or 3 days following administration of the initial dose. The dalbavancin t1/2 is approximately 1 week, and the estimated CL (overall mean = 0.0472 liters/h) and CLR (overall mean = 0.0157 liters/h) are slower than the average glomerular filtration rate of 7.8 liters/h in normal subjects. The mean Vss is approximately 10 liters, a value larger than the average blood volume (5.4 liters) but smaller than the average extracellular water volume (16 liters for normal subjects).
Approximately one-third of the dose of dalbavancin was excreted into urine unchanged (overall mean quantitative excretion of dalbavancin into urine = 33.5%), suggesting that nonrenal routes of elimination play an important role in the elimination of dalbavancin. In contrast, vancomycin and teicoplanin, currently available glycopeptide antibiotics, are excreted almost entirely via the kidneys (12).
In these preliminary assessments, dalbavancin concentrations in blister fluid were roughly equivalent to the concentrations in plasma. These data are consistent with preclinical data (5a).
We have previously shown that dalbavancin is highly bound to serum proteins (M. Cavaleri, A. Cooper, M. A. Nutley, and M. Stogniew, Abstr. 42nd Intersci. Conf. Antimicrob. Agents Chemother., abstr. 1385, 2002) and that MICs in the presence of serum are higher (four- to eightfold) than in broth (3). This difference is less pronounced when looking at the effect of serum on MBCs (one- to twofold higher in the presence of serum). In this study, SBAs were determined under test conditions (50% serum) identical to those used to measure MICs and MBCs. The physical-chemical properties of dalbavancin have, to date, precluded development of an assay for free drug concentrations in plasma samples. With an indirect method by which to measure protein binding, Cavaleri et al. have shown that the free fraction is fairly constant across a large range of concentrations, including those observed in this study. Therefore, total concentrations of dalbavancin in plasma have been used as a surrogate for the free concentrations. Serum samples from subjects who received single or multiple doses of dalbavancin demonstrated bactericidal activity when tested against two MRSA strains. The bactericidal titer and persistence of activity correlated with the dose of dalbavancin administered and with the dalbavancin concentrations determined in the same plasma samples. The data from the present study suggest that bactericidal activity is present when concentrations of dalbavancin in plasma are 20 mg/liter or greater. Given the long t1/2 of dalbavancin, single doses of 500 mg or higher will maintain concentrations above the minimum bactericidal level for at least 1 week. More extensive pharmacodynamic evaluations are needed to determine the importance of this observation.
In summary, the results of this study provide evidence that dalbavancin is well tolerated and has pharmacokinetic and pharmacodynamic properties that support its use in the treatment of serious gram-positive infections. Because of the long t1/2 of dalbavancin and its persistent bactericidal activity, weekly dosing regimens are expected to be a clinical option. Further studies are under way.
This study was funded by Vicuron Pharmaceuticals, Inc., King of Prussia, Pa.
Received 24 April 2003.
Returned for modification 13 August 2003.
American Speech-Language Hearing Association. 1994. Guidelines for the audiologic management of individuals receiving cochleotoxic drug therapy. Am. Speech-Lang. Hear. Assoc.36:11-19.
Campbell, K. C. M., E. Kelly, and N. Targovnik, L. Hughes, C. Van Saders, A. B. Gottlieb, M. B. Dorr, and A. Leighton. 2003. Audiologic monitoring for potential ototoxicity in a phase 1 clinical trial of a new glycopeptide antibiotic. J. Am. Acad. Audiol.14:157-168.
Candiani, G., M. Abbondi, M. Borgonovi, G. Romanò, and F. Parenti. 1999. In vitro and in vivo antibacterial activity of BI 397, a new semi-synthetic glycopeptide antibiotic. J. Antimicrob. Chemother.44:179-192.
Diekema, D. J., M. A. Pfaller, R. N. Jones, G. V. Doern, K. C. Kuegler, M. L. Beach, H. S. Sader, and The SENTRY Participants Group. 2002. Trends in antimicrobial susceptibility of bacterial pathogens isolated from patients with bloodstream infections in the USA, Canada and Latin America: report from the SENTRY Antimicrobial Surveillance Programme, 1998. Int. J. Antimicrob. Agents13:257-271.
Goldstein, E. J. C., D. M. Citron, C. V. Merriam, U. Warren, K. Tyrell, and H. T. Fernandez. 2003. In vitro activities of dalbavancin and nine comparator agents against anaerobic gram-positive species and corynebacteria. Antimicrob. Agents Chemother.47:1968-1971.
Jabes, D., G. Candiani, G. Romanò, C. Brunati, S. Riva, and M. Cavaleri. Antimicrob. Agents Chemother., in press.
Jones, R. N., D. J. Biedenbach, D. M. Johnson, and M. A. Pfaller. 2001. In vitro evaluation of BI 397, a novel glycopeptide antimicrobial agent. J. Chemother.13:244-254.
Malabarba, A., and S. Donadio. 1999. BI 397, glycopeptide antibiotics. Drugs Future24:839-846.
Maranan, M. C., B. Moreira, S. Boyle-Vavra, and R. S. Daum. 1997. Antimicrobial resistance in Staphylococci: epidemiology, molecular mechanisms, and clinical relevance. Infect. Dis. Clin. N. Am.11:813-849.
National Committee for Clinical Laboratory Standards. 1999. Methodology for the serum bactericidal test. Approved standard M21-A. National Committee for Clinical Laboratory Standards, Wayne, Pa.
Ratain, M. J., R. Mick, R. L. Schilsky, R. L. Siegler, and M. Siegler. 1993. Statistical and ethical issues in the design and conduct of phase I and II clinical trials of new anticancer agents. J. Natl. Cancer Inst.85:1637-1643.
Streit, J. M., T. R. Fritsche, H. S. Sader, and R. N. Jones. Worldwide assessment of dalbavancin activity and spectrum against over 6,000 clinical isolates. Diagn. Microbiol. Infect. Dis., in press.
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Antimicrobial Agents and Chemotherapy Feb 2004, 48 (3) 940-945; DOI: 10.1128/AAC.48.3.940-945.2004
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Sir Roger Penrose, OM, FRS is an English mathematical physicist and Emeritus Rouse Ball Professor of Mathematics at the University of Oxford. He is highly regarded for his work in mathematical physics, in particular his contributions to general relativity and cosmology. He has written controversial books on the connection between fundamental physics and human consciousness. In The Emperor's New Mind (1989), he argued that known laws of physics do not constitute a complete system and that human consciousness cannot be explained until a new physical theory (what he terms correct quantum gravity, CQG) has been devised. He argued against the strong AI viewpoint that the rational processes of the human mind are completely algorithmic and can thus be duplicated by a sufficiently complex computer. In 1994, Penrose followed up with Shadows of the Mind and in 1997 with The Large, the Small and the Human Mind, further updating and explaining his controversial theories. His next book, called The Road to Reality: A Complete Guide to the Laws of the Universe, may be the most complete mathematical explanation of the universe yet published.
Video: "The Emperor's new Mind"


NDO – A photo exhibition documenting life in the rear in Vietnam in the mid-20th century opened at the Vietnam Women's Museum (VWM) in Hanoi on April 11.
The event is co-organised by the VWM, the State Archives and Records Department, and the Vietnam Youth Museum as part of activities to celebrate the 44th anniversary of the South's liberation and national reunification (April 30, 1975 – 2019).
Works on display include 100 pictures by photographer Mau Hoang Thiet, featuring Vietnam's northern region during the national resistance war against the US.
Addressing the opening ceremony, Dang Thanh Tung, Director of the State Archives and Records Department, said that the exhibition provides a closer look at the life in Vietnam's northern region, where people worked wholeheartedly to serve as the rear to support the frontline during the anti-US war.
The exhibition not only recreates a vivid picture of the country during the 1954-1975 historic period but also portrays Vietnam as a country with peace-loving and resilient people who were willing to lay down their lives for the motherland.
Veteran photographer Mau Hoang Thiet is one of the founding members of the Vietnam Association of Photographic Artists in 1965. Having more than 50 years of experience in photography, he won the State Awards in 2017, one of most prestigious awards in the country granted to outstanding scientists and artists in recognition of their contributions to the country's development.
After the exhibition concludes on April 15, photographer Mau Hoang Thiet will present all of the photos to the State Archives and Records Department.


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{-|
    Module      : CPE
    Description : Data types and parsers for CPEs
    Copyright   : (c) Stephen O'Brien 2016

    License     : MIT
    Maintainer  : wayofthepie@gmail.com
    Stability   : experimental
    Portability :
-}
module CPE.Parser.CPE where

redpajama_set_name: RedPajamaGithub


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HistoryInquisitionArmadaReconquistaHabsburgBourbonMovida
Believing that God would support Catholic Spain over Protestant England, Felipe II planned to overthrow England to re-establish Catholicism and, as an added benefit, Spain's uncontested control of the seas. Felipe II built up his allegedly "invincible" fleet and sent it off to attack, invade and capture England in 1588. The result? A crippling defeat.
Background of the Spanish Armada
The first and most important thing on Felipe II's mind was the defense of Catholicism against its Christian rival Protestantism. The ultra-religious monarch was not at all happy with the religious movements in the Spanish Netherlands, in what is now Belgium and Holland. The Spanish Netherlands were leaning towards Protestantism, which was quite a big deal especially during this epoch when the rigidly pro-Catholic Spanish Inquisition was at large. Felipe II discovered that England's famed Queen Elizabeth I was behind the scenes helping the Spanish Netherlands' cause, further putting in danger Catholicism's reign throughout the Spanish Empire.
The second of Felipe II's motives was to reclaim Spain's supremacy over trade and sea power. While Spain, following the discovery of America, was undoubtedly the most powerful country of the world, the ambitious Elizabeth I of England was aggressively trying to get in on the action and expand her empire. Needless to say, hers was a plan that interfered with Spain's domination of the seas. Plus, men like Sir Francis Drake, a hero to England but a pirate to Spain, were intercepting and robbing Spain's ships as they brought goods from America back to Spain. Felipe II's reasoning was that if he were to rule over England, not only could he restore Catholicism but he could certainly restore Spain's unrivalled power.
Organization of the Spanish Armada
The key to Felipe II's big plan was the massive fleet of 30,000 men and 130 ships from Spain and Portugal otherwise known as the grand Spanish Armada. That fleet would then link up to army troops in the Spanish Netherlands before launching the attack and subsequent invasion of England. The attack was widely advertised throughout England well in advance, a tactic that Felipe II and his advisors thought would spark fear in tiny England and essentially give in without any hassle.
He was wrong.
The Spanish armada, when sailing in crescent formation, was utterly invincible; however, should it fall out of formation, its vulnerability skyrocketed. That's exactly what happened. As the Spanish Armada approached their first stop - the Spanish Netherlands - they realized the water wasn't deep enough and anchored further offshore. However, something went amiss and two large fighting galleons fell out of formation. England - headed up by one rather famous Sir Francis Drake - quickly took advantage and captured two Spanish ships. From there things just went downhill for the Spanish Armada.
After fierce fighting, both sides essentially ran out of ammunition and the Spanish Armada's efforts had to come to a halt. Unable to pass back through the English channel due to their inability to defend themselves, then had to pass up and around England and Ireland before embarking for home. Facing a shortage of supplies, rough weather, heavy losses and debilitating illnesses, the goal of the Spanish Armada was simply to make it home in one piece.
When the Spanish Armada finally set anchor off the shores of Spain, only 67 of the original 130 ships and 10,000 of the original 30,000 men returned. Needless to say, not exactly what Felipe II had in mind.

redpajama_set_name: RedPajamaCommonCrawl


The original grammar for Agda is somewhat lacking because it's written in regular expressions. However, with tree-sitter, we can now describe the grammar with context-free grammar, which significantly improves the quality of syntax-highlighting and code-folding.
To enable tree-sitter, which is still experimental for the time being, go to Settings > Core, and enable the checkbox saying Use Tree Sitter Parsers at the bottom of the page.


MINSK, 29 January (BelTA) – The Republic of Belarus and the Republic of Korea will engage in talks over the mutual abolition of visas, Shin Gye-ryoon, member of the Strategy and Finance Committee of the National Assembly of the Republic of Korea, Head of the Association of Friendship with Belarus at the Korean National Assembly, told reporters on 29 January after he met with Chairman of the House of Representatives of the National Assembly of Belarus Vladimir Andreichenko, BelTA has learned.
"The two countries are now carefully studying a possibility to conclude a visa abolition agreement. We will collect the necessary information through the embassy (of Belarus – BelTA's note) in the Republic of Korea," Shin Gye-ryoon said.
In his words, the matter had been discussed a day before, during the meeting of Korean and Belarusian MPs. "We got even more determined to sign the agreement in the future. After I come back to Korea, I will continue working on the matter. I think a positive decision will be made," the MP added.
At present nationals of the Republic of Belarus and the Republic of Korea need to obtain visas to enter the territory of the other state. However, holders of diplomatic and service passports can stay in the other country without visas for up to 90 days in line with the bilateral agreement signed on 5 November 2007.
Shin Gye-ryoon has been advocating the abolition of visas between the Republic of Belarus and the Republic of Korea for a long time. He held consultations about this matter in government agencies. The matter was discussed on the level of First Deputy Premier of Belarus.


text:
Lifeflight doctors speak out against privatizing air ambulance service By: Jessica Botelho-Urbanski Posted: 7:00 PM CDT Friday, Nov. 2, 2018 Last Modified: 10:18 AM CST Monday, Nov. 5, 2018 Updates
The entire cohort of doctors responsible for operating Manitoba's Lifeflight program seems poised to quit should the government privatize its air ambulance services.
The entire cohort of doctors responsible for operating Manitoba's Lifeflight program seems poised to quit should the government privatize its air ambulance services.
The Free Press obtained a copy of an Oct. 20 letter sent to Health Minister Cameron Friesen, which outlines the concerns of the 16 doctors.
The letter offers four main critiques of the Tory government's plan to privatize Lifeflight, and emphasizes — in bold lettering — in its conclusion: "We, the medical staff of Lifeflight Manitoba air ambulance, wish to make it clear that we are not prepared to work in an environment that provides substandard patient care and increases risk to patients and providers."
RUTH BONNEVILLE / WINNIPEG FREE PRESS Life Flight vehicle near building at 900 Ferry Rd. The seventeen doctors responsible for the province's Lifeflight program have penned a strongly-worded letter to the health minister criticizing the government's RFP looking to privatize the air ambulance service and are threatening to quit if it happens.
In July, the Manitoba government took a step towards privatizing air services, publishing a request for proposals, so companies can bid on the contracts to operate Lifeflight and the province's fire-fighting water bombers. It's unclear if the contracts have yet been awarded.
Lifeflight is a 24-hour air ambulance service, and its medical staff perform between 400 and 500 trips per year. Staff care for critically ill or injured Manitobans in areas outside a 200-kilometre radius of Winnipeg.
Infrastructure Minister Ron Schuler has previously doubled down on the province's drive to privatize, despite critics calling the move unsafe and pointing out gravel runways in various rural and northern community airports would prevent commercially-licensed planes from landing.
In the letter, the doctors voiced similar objections and noted that — under a public model — Lifeflight has operated incident-free for 33 years.
"When our service provider switches from a publicly owned entity to private industry, there will invariably be pressure on crews to take risks for the sake of maintaining profit margins. Our program was built on the understanding that we would be supported by a publicly owned platform, where crew and patient safety was always the utmost priority," the group wrote.
"Our main concern first and foremost is for the safety of care providers and patients who will be flying on these aircraft. Privatization removes an invaluable safeguard from our program and leaves us all with serious concerns that have not been addressed."
The doctors also alleged: "The willful acceptance of slower transport times for critical care patients in remote northern communities creates two tiers of care in Manitoba: one for the north and one for the south."
The Lifeflight team asked for a "priority" meeting with Friesen nearly two weeks ago. It hasn't happened yet.
Dr. Renate Singh, who directs the Lifeflight program, said her cohort didn't want to conduct interviews with media before sitting down with the minister, so as to give him time to respond to its concerns.
The Free Press asked for an interview with Friesen, but received a statement by email instead.
"We are working to maintain a vital health service that achieves good value for Manitobans, an effort the previous government failed to ever mount," Friesen wrote.
"Our government is interested in hearing from these physicians and look forward to reassuring them that we would never take a step that compromises the level of service Lifeflight offers in any way," he added, noting his office plans to reach out and schedule a meeting early next week.
Manitoba NDP Leader Wab Kinew said the government ought to heed the Lifeflight doctors' warning.
"These are highly-trained physicians, they're specialists in a variety of areas and they're raising the alarm here," Kinew said.
"If you've got the experts telling you that privatization is going to hurt health care, then, as a government, I think you've got to listen and reconsider the plans."
jessica.botelho@freepress.mb.ca
Twitter: @_jessbu
Updated on Friday, November 2, 2018 7:04 PM CDT: headline update
Updated on Friday, November 2, 2018 7:14 PM CDT: Updates headline
Updated on Monday, November 5, 2018 10:18 AM CST: Corrects number of doctors
Lifeflight doctors speak out against privatizing air ambulance service
Ottawa blames Manitoba for holdup, confusion over $67M in carbon retrofit funds
The Free Press hops aboard for Greyhound's final run from Flin Flon to Winnipeg
Midterm elections 'a battle for America's soul'
Florida scores three goals with Jets down a man in second Global Series game in Helsinki
Rejuvenated Laine just what Jets need
Retiring FortWhyte Alive CEO helped create an urban oasis where humans can connect with nature
After 30 years in the radio trenches, Joe Aiello is king of the Winnipeg airwaves
StatCan has some explaining to do
Editorial cartoon for Nov. 2, 2018


text:
T-Mobile & Dallas Officials Under Fire For Infant's…
A mom blames her infant's death on the company and city officials' failure to fix a 911 call center problem.
'White Women Shouldn't Date Black Men' Fliers Posted…
Racist fliers on the campus of Southern Methodist University in Dallas, Texas, urge White women to refrain from dating Black…
Reverend Michael Waters On His Church's Role In…
Reverend Dr. Michael Waters, founder and senior pastor of Joy Tabernacle AME Chuch in Dallas, Texas, is also a professor,…
'Don't Let Hate Infect Your Heart:' Baton Rouge…
Slain Baton Rouge Police Officer Montrell Jackson is remembered as a kind man who was troubled by the wave of…
Black Conspiracy Theory 101: Top 6 Theories About…
The conspiracy theories have already started to fly on social media as racial tensions rise over the deaths of two…
There Must Be A Better Way
(Silver Spring, MD – July 8, 2016) – Radio One, Inc. is deeply saddened and troubled by the recent events…
Dear Mainstream Media, Stop Painting Blacks As Terrorists…
In that moment, I realized that Black lives really don't matter – not just to the law enforcement officers
Bishop T.D. Jakes Delivers Powerful Speech at Dallas…
Bishop T.D. Jakes, whose world renowned church The Potter's House is based in Dallas, Texas, was one of the many…
Celebrities React To Dallas Police Deaths
Twitter Comes To The Rescue After Dallas Police…
UPDATED: Friday, July 8, 2016 The man police identified as a shooter in last night's ambush on police officers is…
Five Police Officers Killed At Protest In Dallas
It's unclear if the protest is directly related to the shooting.
WATCH: Stunning Video Captures Police-Involved Shooting At Dallas…
https://twitter.com/lumworld/status/741326070188806144?ref_src=twsrc%5Etfw A dramatic scene unfolded Friday just before 2 PM EST when a law enforcement officer shot a man at…
Whoop, Hair It Is: Dallas Braiding Stylist Finally…
Who knew that something as innocuous as hair braiding would be a federal judge's concern? But in Dallas it was…
Images From Ferguson (And Beyond)
Eighteen-year-old Mike Brown's death at the hands of police inspired passionate protests in his hometown of Ferguson, Missouri and new…


One of my friend's mothers posted a picture of this food idea on Facebook. I thought it was the weirdest looking thing, and realized that my kids would eat it up (literally and figuratively).
All you need is spaghetti and hot dogs (I'm guessing that sausage or veggie dogs would work fine too). Poke about 6 uncooked spaghetti pieces through the hot dog pieces so they extend out equally on both sides. I thought it would be easy to make them go straight through, but I couldn't get them to do that (not that I tried that hard). They made it through the other side without breaking, but were at angles.
Boil the pasta - following the directions on the pasta package for time.
When it comes out, it will look really odd - with pasta coming through both sides, kind of like worms or guts. My kids were both horrified and fascinated. My daughter said, "that's a meal I'll remember for a long time." My son couldn't figure out how I did it.
I'm not sure I will make it again, but it was fun once!


As an Angelic channel, in prayer and meditation, I received the blessing to bestow twelve doorways of light reflected in an artistic symbolic expression, supporting individual and global transcendence. This artwork is presented in my book, "Sacredness of Life". Additionally, this artistic representation epitomizes the essence of my first book "Twelve Doorways of Light: A Portal to your God-Self".
These Doorways of Light are guiding you through a Divine Portal encompassing God's divine qualities. They are inviting you to navigate within the wonders of life and of your inner sacred being, diving deeper and deeper within the heart of your essence—allowing and activating the divine presence inherent to your Angelic Self. It is your God Self. In that sacred space every human being is invited to live within the consciousness of his or her true Self—liberating divine creative potentialities and possibilities unlimitedly.
"Sacredness of Life" illustrates the Tree of Life embedded within our divine design. The Tree of Life awakens when we choose unconditional love—when our unified heart is activated to reveal and express all qualities of compassion, honoring, and unconditional love. A consciousness of the heart reflects and holds the quintessence of all life.


text:
They speak about us
Orkester Nord
Martin Wåhlberg
Erik Skanke Høsøien
Five Diapasons for Apocalypse!
"Apocalypse" receives five "Diapasons" in a review in the highly influential French magazine Diapason. The review, signed by French critic Sophie Roughol, especially highlights the freshness of the approach and Trondheim Barokk's lively musical drive, "dancing on the alliterations", in these Bachs cantatas that are among Bach's most famous and exuberant works alongside the Christmast Oratorio and his Magnificat.
The CD is available here:
PreviousSuccess for Barbe-Bleue
NextApocalypse: From the Sarrebourg festival
Martin is one of the founding members of Trondheim Barokk, and is playing the cello. He is currently living in Oxford.
Apocalypse: A first-class discovery
CDs available from website
Five "Diapasons" for Apocalypse
Simply Music Club
Trondheim Barokk © 2020
Musician´s login


text:
Lions, Tigers and Imaginary Meridians
You've probably heard about the boy who wrote" The Equator is a menagerie lion running around the Earth".
You've probably heard about the boy who wrote" The Equator is a menagerie lion running around the Earth". Well, I have crossed the Equator several times and not seen a lion, or a line, for that matter. But that is not to say it does not exist. Lines of latitude and longitude are not visible on the Earth's surface either, but they are useful when navigating. Meridians are notional lines connecting acupuncture points on the body. Critics of acupuncture sometimes claim that meridians do not exist because they cannot be demonstrated when dissecting a cadaver the way nerves and blood vessels can be. They are functional, not structural. Acupuncture points can be identified by differences in electrical resistance of the skin compared to surrounding areas. Trigger points cannot be be demonstrated in a cadaver either, as they disappear on death.
Possessing a curious mind and a strong desire to make sense of the differences between Eastern and Western medicine, I appreciated the work of various Western-trained physicians who have demonstrated that many acupuncture points correlate well with known anatomical structures such as motor end-points (where nerves stimulate muscles), sites were nerves pierce fascia - where the nerves can be constricted by shearing forces, or where they exit through openings in bones. About 75% of the most common trigger points are also acupuncture points. The classical tender points required for a diagnosis of fibromyalgia are also acupuncture points.
Fascia is the thick white firm connective tissue which separates muscles, surrounds the brain and nerves, envelopes the organs and delineates the different compartments in the body. Recently I re-read (it was that good!) a fascinating book: The Spark in the Machine - How the Science of Acupuncture Explains the Mysteries of Western Medicine by Dr Daniel Keown. Dr Keown is an emergency room physician and acupuncturist in the UK who relates a number of successful case reports of acupuncture treatment in the ER. But the most interesting aspect of the book is how he shows how acupuncture meridians correlate with the embryological development of different anatomical structures in the body, particularly fascial lines. East meets West in embryology.
When bringing up Eastern medical concepts among medical colleagues one sometimes feels as though one is entering tiger country. Perhaps some latitude could be given to different ways of approaching the same human condition.
David is a fan of books and no doubt will be sharing some good reads here.
Acute Pain Victoria BC
Anatomy Trains
Brain Bargaining
Chronic Pain Victoria BC
Dextrose D5W
Dr John Lyftogt
Eastern And Western Medicine
Meridians
Mindbody Medicine
Myofascial Pain
OldPain2Go
Pain And The Brain
Painful Scars
Perineural Subcutaneous Injections
SFMA
SFMA Selective Functional Movement Assessment
Tension Myoneuronal Syndrome
Tension Myositis Syndrome
Topical Mannitol
Trigger Points


Abstract: The cyclocondensation of trimethylhydroquinone and isophytol to (all rac)-α-tocopherol was studied at the presence of solid catalyst and ZnCl2. The obtained results confirm that the catalytic activity of alumina and silica base catalysts is satisfactory only at the presence of ZnCl2. The strongly acidic aluminosilicates catalyze not only the cyclocondensation of trimethylhydroquinone and isophytol to (all rac)-α-tocopherol but also the formation of unacceptable side products.


While Tasuku is off training and getting rest in the world of the monsters, the Buddy Police sees the need to deputize some of the champions to help protect the Earth. Gao, Tetsuya, and Zanya Kisaragi are among those deputized, and it's just in time. A new enemy arrives, Ikazuchi, with the deadly 100 demons, all rogue monsters. Now the new trainees and the Great 8 monsters must fight to protect Earth from being consumed by these new rogues.
Luminize! Super Dragon Fifth Omni Formation!!
Suzuha Blushes! A Love Letter from Tiger!!
Tetsuya Weeps!The Demon Lord vanishes in the Void!
Miserea's First Battle! Friendship Through the Ages!
Drum Kidnapped! Gao vs. Shigamine!
Save Jack! Tasuku Goes to the Future of Despair!
Star of Hope! Radiant Guardian, Jackknife "Aster"!!
Rouga vs. Eighth Omni Deity Lord, Grangadez!
Ikazuchi's Return! Mikado Family Under Attack!!
Omni Lords Assemble! Seal Yamigedo!


text:
Latidos de pánico (1983)
...aka: Cries of Terror
...aka: Frantic Heartbeat
...aka: Panic Beats
Paul Naschy
This isn't all rotten if you hang in there. It's like a trashy Gothic soap opera running at half-speed with pretty decent acting, mild sex scenes, plenty of female nudity and a hilariously mean-spirited and lecherous roster of characters who use, deceive, manipulate, seduce and kill other people without thinking twice about it. It opens with a foggy, great-looking, atmospheric scene of infamous sadist Alaric de Marnac (laid over from Naschy's fun 1972 film HORROR RISES FROM THE TOMB) tracking down a (nude) victim on horseback before mauling her to death. In modern times, Alaric's look-a-like descendant Paul (Paul Naschy/Jacinto Molina) decides to take his terminally ill, wealthy wife Genevieve (Julia Saly) out to his secluded childhood home for a much needed break from the stress of big city life (and possibly buy her some more time). Waiting for them at the home are elderly maid Mabile (Lola Gaos), who's been around since Paul was a young child and used to spook him with stories about the family lineage, and her sexy niece Julie (Paquita Ondiviela), who had a rough childhood and claims she is looking to make something of her life. A month after arriving in the home, Genevieve has gotten close to both Mabile and Julie and her health is improving, but the peace doesn't last long as she's haunted by mysterious visions of Alaric back from the dead. It doesn't take a rocket scientist to figure out that the forces conspiring against her are actually in human - not spirit - form, and said forces want her dead to get her money, but the less I reveal about this one the more you will probably enjoy it. It does sound like your standard issue psycho thriller, and in most ways it is a bit on the ordinary side, but the story does hold a few surprises that I won't spoil.
One of the things that this movie has going for it is that none of the characters are portrayed as saints and there's a certain duality to everyone, making the interplay between them a bit more interesting and unpredictable than what you normally see. The cinematography is competent; very stylish and colorful any time some-thing "supernatural" is going on. The four leads are all good. Plus there's one moment of over-the-top gore that will definitely catch you by surprise. It's worth a look. Also in the cast are Silvia Miró as Naschy's mistress, Manuel Zarzo and José Vivó as doctors and Salvador Sáinz as a priest.
Go straight for the Mondo Macabro DVD (an excellent print with a load of interesting special features); quality for the Spanish language VHS version and the subtitled VSOM video don't do the film justice.
Labels: haunted house, nudity (lots), Paul Naschy, Spain
Cannibal Holocaust (1979)
Blood and Lace (1971)
Come With Me, My Love (1976)
Circus of Horrors (1960)
Amityville 3 (1983)
Amazing Transplant, The (1970)
La vendetta di Lady Morgan (1965)
Weirdo, The (1989)
Zombie Death House (1988)
Horror Show, The (1989)
Haunted: The Ferryman (1974) (TV)
Horror Hospital (1973)
Halloween II (1981)
Halloween III: Season of the Witch (1982)
El buque maldito (1974)
Ozone Attack of the Redneck Mutants (1986)
Omen, The (1976)
Midnight (1989)
La mansión de los muertos vivientes (1985)
Baba Yaga (1973)
Tenderloin (1985)
Psycho II (1983)
Psycho III (1986)
Revenge of the Stepford Wives (1980)
Returning, The (1983)
Private Parts (1972)


"In France, as in other parts of Western Europe, the reigning explanation for unemployment was what economists call the "lump of labor" theory. The theory holds that a society has only a fixed amount of work that needs to be done, and therefore the only way to reduce unemployment is to share the available work. This was reflected in Mitterrand's initial program. The government lowered the retirement age to sixty to push older people out of the workforce; this was expected to create openings for youngsters, on the assumption that each employer needed only a certain amount of labor and would replace departing workers one for one. Workers who reached age fifty-five could collect pensions equal to 80 percent of their wages if their employers agreed to replace each retiree with a worker under twenty-five. The regular workweek was cut from forty hours to thirty-nine, and the maximum workweek was reduced as well, in the expectation that employers might cover those hours by adding workers. The possibility that less work for the same pay might deter hiring, or that young workers might lack the skills of the experienced workers they were replacing and therefore have lower productivity, was not widely discussed in the France of 1981."


All Blacks coach Steve Hansen was quick to anoint Ireland as Rugby World Cup favourites after their win in Dublin last weekend but with a week left in the 2018 season, Wallabies halfback Will Genia says world rugby is as strong across the board as he has ever seen.
And with stats showing the northern hemisphere has been dominant since the last World Cup, England coach Eddie Jones believes there are now "eight teams that are contenders" to win the Rugby World Cup in Japan in 2019.
It was less than three months ago that New Zealand Herald columnist Chris Rattue declared New Zealand certain World Cup winners, after a big opening Bledisloe Cup win in Sydney.
Since then, New Zealand lost to South Africa at home, scraped past England at Twickenham and went down to Ireland in a brutal encounter in Dublin.
That's not to say the world no. 1 All Blacks are suddenly weak and vulnerable, but it's fair to say there are a greater spread of contenders for the William Webb Ellis Cup than ever before.
The four big Southern Hemisphere nations filled the four semi-final slots at the 2015 Rugby World Cup but the chances of that happening again seems fanciful in 2019, with England and Ireland particularly improving since that tournament, and Scotland and Wales also emerging in strength.
In the three years leading up to the 2015 tournament, the home nations of England, Wales, Scotland and Ireland, as well as the British and Irish Lions, won 18 of their 55 Tests against the four Rugby Championship nations.
In the three years since that Rugby World Cup, that number has risen to 33 wins from 51 Tests played, a win percentage of 64 per cent.
If you take Argentina out of the mix in the Southern Hemisphere, just pitting the home nations against New Zealand, South Africa and Argentina the rise goes from just a 20 per cent (9/45) win rate in 2012-14 to 53 per cent (22/40) in the past three years.
The Wallabies' Northern Hemisphere defeats - they've lost to Ireland, Wales, Scotland and England in the past year - have been well-documented but South Africa has also been beaten by England and Wales in the past 12 months.
Asked if he felt rugby across the globe was as strong as he had seen in his career, Genia was unequivocal.
"Definitely, it's more competitive right across the park," he said.
"A whole bunch of teams can win (the World Cup).
The Wallabies certainly won't be reading much into form a year out from the tournament, with 2015 an exercise in how much the landscape can change in less than a year.
"All I can say is that a lot can change and happen between now and the World Cup," he said.
"That has been shown to the point that people were saying just give the World Cup to New Zealand and they have just lost to Ireland.
"But from a personal point it's not something I really think about.
Genia said he was happy to let others decide whether the northern teams had tipped the power balance in their favour in recent times.
"Ireland beat the All Blacks and Steve Hansen says they are now the best team in the world," he said.
"I don't know, it's always been a challenge coming here and it is more difficult now with the results we have had against England, Ireland, Scotland and Wales.
"I think there's about eight teams that are contenders. I think Ireland's definitely a contender," he said.
"It will have no consequence on the World Cup. None at all.
"The only thing it shows is just where rugby's going.
"The game's becoming more brutal, more physical, longer, shorter periods of play, and the physical demands of the players are just getting greater and greater.
"And the mental demands - it's funny because now the game's longer, the players have got more time to think.
"So, you've got this, almost you've got the physical strand going up here and then you've got the mental strand or the thinking strand at the same time."
South Africa coach Rassie Erasmus told reporters this week, it was impossible to predict who would even make the semi-finals in 2019.
"Where the World Cup is going to be played in Japan it's going to be warm and humid. It won't be a southern hemisphere team that benefits from it and I don't think a northern hemisphere team will really benefit from it.
"So the playing field is pretty level. I don't think you can put your hand up and say: 'This is the four teams that are going to be in the semi-finals'.
Jones said one certainty was that the All Blacks would come back better in 2019.
"If I was Steve Hansen, I'd probably be hurting a lot now but I'd have the knowledge that we're going to learn a lot from this game and they'll come back stronger and better, their players will be hurting," he said.
A New Zealand Herald column on Tuesday put the Kiwis' inconsistency of late down to the form of the Wallabies and the rest of the Rugby Championship.
Asked about that suggestion, Hansen said there was "something missing" with the Wallabies but playing more northern teams would be fine World Cup preparation.
"I was thinking about that this morning," he said to the New Zealand Herald.
"There is no doubt the style of game that is played by South Africa is similar to the style played up here.
"I still believe Australia are a really good rugby side. There is definitely something missing because they are not quite right and are not performing to the level they can.
"But the more we play teams like South Africa, Ireland and England, France which we have done this year it is good for us. We have had a bit of a preview so to speak."
The Wallabies take on England on Saturday November 24, kicking off at 3pm local, Sunday 2am AEDT, LIVE on beIn Sports and SBS.


text:
Q: Meaning of infinite self inductance I  am reading about the characteristics of an ideal transformer and it is mentioned that self inductance of each coil is infinite. Could someone help me to understand the physics behind it? When self inductance goes to infinity that means that the voltage across the coil goes to infinity and I have a large magnetic flux and current. I was wondering if this is a right conclusion.

A: If self inductance is infinite, then any rate of change of flux would generate infinite voltage, but look at it the other way. Any amount of back emf can be generated with infinitesimally small rate of change of flux. When we apply a voltage to the primary of a transformer (with no secondary load), an equal and opposite back emf is initially generated and no current flows. In order to maintain the back emf, there must be a rate of change of flux, which requires an increasing primary current. The larger the self inductance, the smaller the rate of current rise  required to maintain the emf. As self inductance approaches infinity the rate of rise of current approaches zero. So in the ideal transformer one could apply a voltage to the primary for ever with no current flow. The voltage across the socondary will be the primary voltage times the turns ratio. The current in the primary will be the secondary current / turns ratio.

A:
Could someone help me to understand the physics behind it?

If we mathematically allow the primary and secondary self-inductances of an otherwise ideal transformer go to infinity, the low frequency response of the transformer goes to zero frequency.  That is to say, an ideal transformer transforms DC voltage and current just as it does AC voltage and current.
Put another way, if the primary and secondary inductances are finite, the otherwise ideal transformer has a low frequency corner frequency - it cannot be used as a transformer to arbitrarily low frequencies.
In the case of a uncoupled inductor, letting the inductance go to infinity essentially results in an ideal current source.
You may know that an ideal voltage or current source has 'infinite' (unlimited) energy.  Since the energy stored in an inductor is
$$W_L = \frac{1}{2}Li_L^2$$
it follows that, for non-zero current through, an inductance of infinity implies infinite energy stored.
Further,
$$v_L = L \frac{di_L}{dt}$$
implies that an inductance of infinity permits no rate of change of current through for a finite voltage across.
In other words, such an inductor will maintain a constant current through for any finite voltage across; it is an ideal current source.

redpajama_set_name: RedPajamaStackExchange


ACTION ALERT: Don't Gut Global Protected Area Targets!
There is a real risk that the World Parks Congress will gut the updated target they issue for no-take marine protection.
At the last World Parks Congress in Durban 11 years ago – a marine no-take target was issued of 20-30% no-take of all habitats by 2012. WPC is a global expert forum – that target had the status of providing expert advice to the world's leaders, governments and convention processes on what they should aspire to achieve. There is a very real risk that that target will be reduced to 5% no-take as the global marine target. This would be a disaster for marine protection globally, and all of the marine park campaigns and programs around the world.
This large target is still on the table, but we need to hold that in place for the next 24 hours leading into the final day of WPC tomorrow when the targets will be locked-in. Today is the last day for influencing this, ahead of tomorrow's WPC Plenary when the WPC Resolutions will be confirmed.
Can you use Twitter and Facebook as soon as possible today to send a message – a suggested one is below. Reword this as you wish, but please keep the tone sharp but encouraging – no need to mention any numbers. Please use the hashtag #NatureNeedsHalf.
I'm sitting here at the airport in Quito thinking about the incredible week here at the Eleventh Meeting of the Conference of the Parties to the Convention on Migratory Species. I'm also thinking about the long and painful journey ahead of me and my fellow Fijian delegate, Saras Sharma of the Ministry of Fisheries. Sharma, by the way, is sleeping on a seat next to me in the departure lounge. I am really envious of people who sleep so easily! She'll need it. Over the next two days we are flying from Quito to Miami to Los Angeles and finally on to Fiji. I'll get a lot of reading done – you can only watch Guardians of the Galaxy so many times – but I expect my bottom is going to be very sore again!
As I sit here I am in very high spirits. Yesterday marked a monumental moment for shark and ray conservation. All 21 species of sharks and rays that were proposed for listing on CMS Appendices I and II were adopted by the plenary during the last day of deliberations at the CMS COP 11. Even Chile and Peru, who had initially been opposed to the listing of silky sharks, came around in the eleventh hour and voiced their support.
Congratulations are due to all the countries that were successful and I sincerely thank everyone for supporting Fiji's proposals!
As a member of the Fiji delegation I am immensely proud of my country and fellow delegation members. We took our first CMS COP by storm with a proposal to list 9 mobula and reef mantas on the two appendices. I am truly honoured to have been a part of this fabulous team led by our gentle giant and personification of humility, Mr. Aisake Batibasaga of the Ministry of Fisheries. His leadership was a pillar of strength for us less-experienced members of the delegation. Saras managed everything for our team from before we left Fiji until now. We were blessed to have her be our calm, yet surprisingly firm, voice. My buddy Ian Campbell of the WWF Shark Programme was our joker and also technical person, and despite his bad jokes, he proved to be indispensable.
Thank you to our hosts, the Ecuadorian government, particularly the Minister of Environment Lorena Tapia, and the wonderful people of Ecuador for being delightful hosts and allowing us to experience and enjoy their beautiful home.
Congratulations and heartfelt thanks to the CMS Secretariat for all the hard work and making this COP a memorable and productive one.
Thank you to all our partners who helped the Fiji delegation with drafting our proposals and getting us to Quito. The Pew Charitable Trusts, WWF, The Manta Trust, and SPREP head this distinguished list.
And huge thanks to all the bubbly personalities from around the world. It was particularly great to see Perry, Luke, Isabel, and KerriLynn again.
I have been working on shark conservation for a few years. Yet this was the first time for me to work on shark conservation on the global stage. I am filled with happiness and am grateful to have had had the opportunity to be but a small part of this.
I hope this feeling lasts the entire 48 hours or so it is going to take to get me back to my own bed in Suva, Fiji. I leave inspired, knowing that our work is only just beginning. The theme of CMS COP 11 was "Time for Action," and I plan to take this home as my personal mantra in the coming months.
We have reached the threshold where human inaction may lead to a bleak future, not only for migratory species and nature, but for us humans also. We must take the steps necessary to set things on the right track.
Challenge accepted, and I humbly ask you to join me.
Arthur Sokimi is the director of outreach for Shark Defenders. He lives in Suva, Fiji. You can follow Arthur on Twitter.
After approximately 30 odd hours of flying and playing paper rugby in airports, the Fiji delegation arrived safely in Quito, Ecuador for the 11th Conference of the Parties to the Convention on the Conservation of Migratory Species of Wild Animals (CMS). Jetlagged and with very sore bottoms, we settled into our accommodations and after a little rest put our heads together again to work on our proposal to list nine mobula species, plus reef mantas.
The entire team has been quite anxious since this is Fiji's first ever appearance at CMS and we are making it a spectacle with a proposal. Actually Fiji is the first Pacific Island country to make a proposal at CMS! Lead by our towering Head of Delegation, Mr. Aisake Batibasaga, we are optimistic and we live the theme of this years' COP; "Time for Action"!
The Fijian delegation inside the meeting hall.
UNLESS we learn to live in harmony with nature there is NO future for us!!
This is the very important message that must be shared with everyone. This is what everyone on earth should know, should think, and should talk about. It cannot be stressed, repeated or shouted enough!
Today's opening ceremony was a pleasant occasion with the hosts Ecuador going out of their way to make everyone feel welcome with very inspirational talks from three conservation advocates. One of the opening addresses was given by Achmat Hassiem, Paralympian 100m Bronze medal winner in the London Paralympics and World Champion 200m butterfly champion, who lost a leg to a shark back in his homeland of South Africa.
South Africa and Fiji together for sharks!
On one prosthetic leg, the man from South African stood tall and spoke passionately on the need for strong shark protections. I admire this man greatly! I try to put myself in his shoes and I realize how strong a character a person must have to be the way he is. Positivity unleashed! Yesterday it was said that nature cannot speak for itself but it chooses to react. Today I watched and listened to a hero speaking for sharks and nature! Now is time we listened to the champions that voice the cry of nature and heed their call before nature is forced to respond in a way that will not be favourable to the planet and those that live on it.
Greenpeace is warning potential Bumble Bee Foods suitors about what it says are risks associated with the company, including alleged links to illegal fishing. In an alert Greenpeace said it sent to companies reported to be bidding for Bumble Bee, the environmental group cited a $125,000 out-of-court settlement by a vessel from Bumble Bee supplier South Pacific Tuna Corporation (SPTC). The vessel had been charged with illegal fishing in the Marshall Islands, Greenpeace said.
Chris Lischewski, president and CEO of Bumble Bee Foods, blasted Greenpeace for a note sent to the media and potential purchasers of the company.
Bahamas authorities are tackling iIlegal, unreported and unregulated (IUU) fishing, as crawfish yields are down by up to 30%, reports Tribune Business. On Oct. 26, two Dominican registered vessels and a group of Dominican fishermen were reportedly apprehended for fisheries violations in southern Bahamian waters.
Ocean conservation group Oceana released a study today showing that 30% of sold shrimp products are misrepresented, with 15% of the tested shrimp being straight-up mislabeled in production method (wild-caught vs. farm-raised) or species type.
Shrimp may be small, but they are a big business and a popular food for many Americans. In fact, America's most popular seafood is shrimp, and it is the most highly traded seafood item by value, both in the U.S. as well as around the world. In 2012, 89 percent of the shrimp consumed in the U.S. was imported. With a product that is so heavily traded comes a high risk of misrepresentation that cheats consumers, honest fishermen and others.
A team of 17 National Oceanic and Atmospheric Administration (NOAA) divers sailing aboard NOAA Ship Oscar Elton Sette recently returned from a 33-day mission to remove marine debris from Papahānaumokuākea Marine National Monument in Hawaii, a World Heritage Site and one of the largest marine conservation areas in the world.
Bogus Kobe beef. Bad sushi. Poseur parmesan. Bastardized olive oil. Tainted honey. Horsemeat swapped for beef. Fake fish on menus and in stores nationwide. If you love good food, there's always another scary scandal around the corner, another shoe waiting to drop. It just did.
A Chinese tuna company's draft IPO has offered an unusually candid view of how China defies international agreements seeking to regulate catches and preserve fish stocks.
Hong Kong-listed Pacific Andes International Holdings said it is in talks to raise more debt as it said it could not account for the "unusual" fluctuation in its share price and trading volume seen on Monday, Oct. 27.
The Philippine Senate approved a bill Monday to strengthen laws against illegal, unreported and unregulated fishing, to prevent the European Union from blacklisting its products. The amendment to the Fisheries Act will impose stiffer fines and more administrative penalties.
Environmental group Sea Shepherd is heading to the Southern Ocean to combat toothfish piracy.
Jakarta (ANTARA News) - The newly-appointed Minister of Marine Affairs and Fisheries Susi Pudjiastuti said she would eliminate illegal fishing activities rampant in Indonesian waters for the past several years.
President Mahinda Rajapaksa on Thursday (30) instructed the Sri Lanka Navy to assist in stopping illegal fishermen entering into the Sri Lankan seas and also to curb using illegal equipment for the fishing.
ABARES has released the Fishery status reports 2013–14, which include the most up-to-date assessment of fish stocks that are solely or jointly managed by the Australian Government.
The inauguration of Joko Widodo and Jusuf Kalla as President and Vice President marked a start to their efforts to realize their platforms, which include the much heralded "maritime axis". Such a vision is quite reasonable due to the maritime culture that has been in place for centuries, as evident in the old song lyric "Our ancestors were sailors".
Combined efforts of government operatives led to the apprehension of five trawl fishing boats in the municipal waters Manapla. nThe operation took place in Barangay Punta Mesa, Manapla town amidst heavy downpour as five trawl fishing boats were spotted violating Republic Act 8550 particularly the prohibition on the use of Active Fishing Gear within Municipal Waters and Bays and other Fishery Management Areas.
President Mahinda Rajapaksa instructs the Navy to assist in stopping illegal fishermen into the Sri Lankan sea. He has also asked them to curb using illegal equipment for the fishing.
By December, the European Union will decide on the status of the Philippines as a noncooperating third party in its campaign against illegal, unreported and unregulated fishing (IUUF). Last June, the Philippines received a "yellow card" from the European Union; the sanction was only a warning and did not entail trade measures. The formalization of this dialogue process served to strengthen the cooperation between the European Commission and the Philippines to address all problems within a logical time frame of six months.
Bangladesh Navy personnel on Monday arrested nine Indian fishermen along with a fishing trawler for their illegal entry into Bangladesh maritime boundary.
With the European Union (EU) deciding to impose a sanction on Sri Lankan fisheries products, there is lot of agitation created especially among the fisher folks. Some fisher groups who will be affected by this decision recently protested in front of the Ministry of Fisheries who received them with hostility.
Oceana says that despite overfishing, the EU is still "refusing" to take action to protect stocks of Mediterranean swordfish. It has uncovered a report that reveals how the Italian fleet "blatantly violates" current international fisheries measures in place to protect the species. This comes shortly before the issue is due to be discussed at next month's International Commission for the Conservation of Atlantic Tunas (ICCAT) meeting in Brussels.
As EU Member State representatives met in Brussels to discuss the EU position on the management of highly migratory species such as bluefin tuna and swordfish, Oceana has unveiled a report by the European Commission that proves how the Italian fleet violates current international fisheries measures in force for Mediterranean swordfish.
The Ministry of Agriculture, Food and Environment (MAGRAMA) imposed pecuniary penalties and inability to conduct fishing activities on Spanish crew registered on a foreign vessel included in the blacklist of the Convention for the Convention on the Conservation of Antarctic Marine Living Resources (CCRVMA) for illegal fishing in Antarctica.
Gambia's National Platform for Sustainability Fisheries was launched on Oct. 21 with the aim to promote governance management while reducing poverty, reports The Point. bThe platform is intended to apply sustainable measures for socio-economic development of the West Africa Marine Eco-Region (WAMER) member countries.
The government has vowed to enforce stiff penalties on offenders using illegal fishing gears in search of quick wealth, as they create irreparable destruction of marine ecology.
THE government is constructing an offshore patrol vessel to survey the Indian Ocean exclusive economic zone. Fisheries Cabinet Secretary Felix Koskei said the vessel will strengthen the country's capacity to patrol the EEZ.
After 1984, when the first purse seiners converge on Port Victoria to make it the main tuna transshipment centre, we are now seeing the arrival of dozens of long liners.
More people are giving thought to where their food comes from, and there is perhaps no better example than seafood. With the power of global logistics, it is possible to enjoy fresh lobster, fish, shrimp, and other delicacies of the deep in a restaurant thousands of miles from the nearest coast. However, eco-conscious consumers increasingly want to know where their food originated and whether it was harvested in an environmentally sustainable fashion.
Damanzaihao, the flagship mothership of Pacific Andes formerly known as Lafayette, has been included on the draft list of illegal, unreported and unregulated (IUU) fishing drawn up by the South Pacific Regional Fisheries Management Organization, Undercurrent News has learnt.
A shadowy Chinese super-fishing boat that changes flags and names routinely as it illegally plunders the South Pacific is to be declared a pirate ship by a Wellington based international control agency. Damanzaihao, flying the Peruvian flag, it is the world's largest fishing vessel at 49,367 tons but no one knows what it does in the waters between New Zealand and South America.
Illegal, unreported and unregulated fishing (IUU) is a major challenge and concern for ACP countries, a number of which have faced sanctions under the European Union's IUU Regulation.
People aren't the only ones affected by identity theft. Tankers, cargo freighters and other ships sailing in the Central Pacific and off the coast of West Africa are increasingly pretending to be vessels that they're not, according to a startup.
The Environmental Investigation Agency (EIA) has called for a 10 year moratorium on Arctic shipping according to a report released on 21 October. The group, an established UK group that works with local NGOs, film, and television to reveal environmental crimes through undercover methods, believes it will take this amount of time for the IMO's Polar Code to be approved and written into national legislations.
Every fish you eat is an environmental mystery, but would you pay more to know the truth?
Once you've seen what comes up in the net after a trawling expedition, you can never take the identity of the seafood on your plate for granted again.
On October 20, 2014, Pohnpei Governor John Ehsa, Chief of Staff Falcam on behalf of FSM President Emanuel Mori, and other state leaders attended a ceremony at Pohnpei International Airport unveiling a new welcome sign which celebrates the state's shark protections. With the passage of Chuuk's law in May, all four states now fully protect sharks in their waters. A draft bill is currently being reviewed by the FSM National Government which would create a shark sanctuary in FSM's exclusive economic zone (EEZ).
In 2011 at the Micronesia Chief Executive Summit, the Presidents and Governors of Micronesia, committed to create the Micronesia Shark Sanctuary. The administration and its NGO and private partners have been working with members of the FSM National Congress to have this draft legislation passed to fulfill its regional commitment and to secure the nations ocean resources for future generations.
The unveiling comes on the heels of a recent resolution by Pohnpei's traditional leaders who called on the Congress to pass legislation for the creation of a shark sanctuary in FSM's national waters. More than 8,000 Micronesian students have signed a petition in support of an FSM shark sanctuary. The signers come from all four states of FSM, Palau, the Northern Mariana Islands, the Republic of the Marshall Islands, and Guam.
Approximately 100 million sharks are killed each year and the latest science finds that nearly 30% of known shark species fully assessed by scientists are threatened with extinction. Sharks are currently unprotected in FSM's EEZ with the exception of oceanic whitetip sharks and silky sharks, which are protected by regional agreements under the Western and Central Pacific Fisheries Commission (WCPFC).


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Q: Angular 4 - access formControl state through ng-content I want to create custom styling for my form elements. Therefore I have to add a parent element to each input and select element. The parent element will contain the CSS classes for the styling. Example:

  <input formControlName="foo">

  <input formControlName="bar">

  <input formControlName="baz">

I am looking for a solution where I can replace the outer DIV with a component that watched the child input state and figures out what classes are needed. Renders the DIV in it's template and transcludes the input element. So my form template would look something like this.
<form-field-container>
  <input formControlName="foo">
</form-field-container>
<form-field-container>
  <input formControlName="bar">
</form-field>
<form-field-container>
  <input formControlName="baz">
</form-field>

I am using Reactive forms.


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'Undertaker: The Last Ride' Review: Chapter One
ByJason Jarman
May 11, 2020 TheLastRide, Undertaker, WWE, WWENetwork, WWEUniverse
It's easy to look at Undertaker: The Last Ride as a blatant WWE cash-grab.
Certainly, WWE isn't above capitalizing on a mainstream success. In this case, ESPN's hit docuseries The Last Dance. But while the world at large knows Michael Jordan and Phil Jackson? Nobody really knows the real Undertaker.
Mark Calaway.
Most people in pro wrestling don't know the man behind the Deadman.
And after the first chapter of Undertaker: The Last Ride, it's fair to most fans probably won't know him much better.
Chapter One, 'The Greatest Fear,' goes into the mind of the Undertaker to find out what it is that drives the Phenom. It goes deep. But it fails to come away with a real thesis.
The Greatest Fear
Undertaker: The Last Ride begins with Undertaker's match against Roman Reigns at WrestleMania 33 weighing heavily on his mind.
Compiling interviews with industry legends like Jim Ross, Shawn Michaels, and Steve Austin, Undertaker: The Last Ride gives us an inside look at the Undertaker. But it's one we've seen a million times before. It's a look from the outside in.
It's interviews with the Undertaker himself and his wife, Michelle McCool, that help peel the onion that is the Deadman.
Undertaker openly worries that he might not be up to the task of going into the ring with Reigns. This is the key of what Undertaker: The Last Ride does well. Hearing the Undertaker's thoughts and insecurities.
"At this point in my career, I can't work a full schedule," he says. "There. I said it."
By the time the curtain falls on chapter one of Undertaker: The Last Ride, though, the real mystery comes to light. What is this docuseries about, anyway?
Of Streaks And Concussions
The only real thesis I'm able to grind out of Undertaker: The Last Ride is that Mark Calaway is a real human being.
That, in and of itself, makes chapter one a success. Humanizing the Undertaker after he's been a mythic figure for 30 years is difficult. It's clear that the focus in chapter one of Undertaker: The Last Ride is on his trepidation about WrestleMania 33 bout.
We see glimpses of the aftermath of Brock Lesnar ending the streak at WrestleMania XXX. Some of which was already seen on The Broken Skull Sessions with Austin. Like not remembering his name for hours after the fact. But some are new. Like Undertaker needing a pep talk before heading out to face Bray Wyatt at WrestleMania 31.
Everything culminates with Undertaker coming out the loser against Reigns at WrestleMania 33.
I get all of that. What the doc is going for is clear. And it all makes Undertaker: The Last Ride a compelling watch. But the mystery remains.
Undertaker: The Last Ride chapter one is the episode to set the stage for the entirety of the docuseries.
But when it's over, I still don't know what the piece is supposed to be about in its entirety. Is this setting up what will really be Undertaker's last match? Or is it hinting that Undertaker will never be satisfied until he erases the pain of under-performing against Lesnar at WrestleMania XXX?
There's a segment of the interviews where Undertaker acknowledges that his place on any given card means someone else is being kept off that card. Undertaker: The Last Ride goes to great lengths to show how important it is for the Undertaker to make his match worthwhile.
Chapter one makes very clear that Undertaker doesn't want to become a parody of himself.
But where do we go from here? In terms of pacing, Undertaker: The Last Ride might have been better served by covering stuff that we already know. His debut at Survivor Series 1990, the development of the character. The early days. But we know that already.
Undertaker: The Last Ride has an unenviable task of hitting the ground running almost in medias res.
All of that is relatively inconsequential to this first chapter. I'd be more worried if Undertaker: The Last Ride didn't make me wonder what was coming next.
And in that respect, Undertaker: The Last Ride is definitely a hit in its first outing.
New chapters of Undertaker: The Last Ride, a six-part docuseries, air Sunday nights on WWE Network.
All images courtesy of WWE.
'Undertaker: The Last Ride' Chapter 1 - The Greatest Fear
Entertainment Value
The sheer rarity of getting into the mind of the Undertaker
Solid cast of interview subjects
Mark Calaway might be the realest guy in wrestling
Room for the rest of the series to expand
But honestly, where IS this series going?
It's early in the series, but starting in the middle of the story is a strange choice
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About That Sex and the City Reboot: Everything We Know About And Just Like That
It's happening. Sex and the City is coming back. In January, news broke that the popular early aughts HBO show would be continuing HBO Max in a revival called And Just Like That…
by : Hilary Weaver- Mar 12th, 2021
This story originally appeared on ELLE US
In an interview with Vanity Fair, Sarah Jessica Parker, who famously walked the streets of Manhattan in her Manolo Blahniks for six seasons and two movies, said she's anxiously awaiting what showrunner Michael Patrick King and the otherwise all-women writers' room is cooking up.
"I think that Cynthia [Nixon], Kristin [Davis], and I are all excited about the time that has passed," she said. "You know, who are they in this world now? Have they adapted? What part have they played? Where have they fallen short as women, as friends, and how are they finding their way? Did they move with momentum? Are they like some people who are confused, threatened, nervous [by what's happening in the world]? I'm so curious and excited to see how the writers imagine these women today."
You'll notice that Parker named herself, Nixon, and Davis, but omitted the name of the fourth star of Sex and the City, Kim Cattrall. This was, of course, a purposeful move. When HBO Max announced the SATC revival, Parker confirmed on Instagram that Kim Cattrall (Samantha Jones) would not be joining the cast for this project.
"No. I don't dislike her. I've never said that. Never would," Parker said, refuting a commenter's claim that the two "dislike each other." She went on: "Samantha isn't part of this story. But she will always be part of us. No matter where we are or what we do." The commenter was referring to the infamous rumored feud between Cattrall and Parker.
That juicy gossip aside, here's what else we know about the HBO Max revival.
There will be 10 half-hour episodes.
Parker, Davis, and Nixon are signed on as executive producers of the new show, per The Hollywood Reporter. So far, this is slated as a limited series, but if we know anything about the seemingly endless stamina of Carrie Bradshaw and co., it could continue way past the 10 episodes HBO Max has currently green-lit.
The writers' room has begun working.
Us Weekly reported in late February that the writers' room opened in January. As Vanity Fair also reported, the writers' room is made up entirely of women, and Parker referred to the writing staff as "incredibly diverse in a really exciting way." She added that the staff will add "life experience, political world views, and social world views" to the series.
In February, Deadline announced members of the writers' room include Shrill and Tuca & Bertie writer and Wow, No Thank You author Samantha Irby, who will also serve as co-producer; Parks and Recreation alum Rachna Fruchbom, who will also co-executive-produce; Twenties, Black Lightning, and Being Mary Jane alum Keli Goff, who will serve a supervising producer; and Julie Rottenberg and Elisa Zuritsky, who both worked on the original series and will serve as executive producers.
We don't know exactly when the show is coming.
And Just Like That… does not have a release date right now, but Us Weekly says filming is beginning this spring. Obviously, COVID-19 has been a big roadblock much of TV and film production for the past year, but with vaccines well underway and lots of tricks up the sleeves of talented showrunners, filming in the time of COVID is not impossible.
COVID-19 will be mentioned in the revival.
Speaking of COVID, it doesn't seem as if the writers are just going to ignore the pandemic, which completely devastated New York City last spring. Parker told VF that COVID-19 will "obviously be part of the storyline, because that's the city [these characters] live in. And how has that changed relationships once friends disappear? I have great faith that the writers are going to examine it all." This statement had some fans speculating that Samantha would die from the effects of the virus.
They are not killing off Samantha.
Fans can take a sigh of relief that their worst fears are not coming to fruition in And Just Like That… In an interview with TVLine, HBO Max chief content officer Casey Bloys seemed to indicate that the character of Samantha just goes her own way—but doesn't die. Bloys added that, "just as in real life, people come into your life, people leave."
He added: "Friendships fade, and new friendships start. So I think it is all very indicative of the real stages, the actual stages of life… They're trying to tell an honest story about being a woman in her 50s in New York."
So, looks like they just…ghosted each other? But no one is a ghost. Damn, not gonna lie, the latter would have been interesting. Can you imagine a series of unexplained events that the women eventually blame on Samantha's ghost?
It's still not clear if Mr. Big is coming back.
Another big casting question surrounds Carrie's love interest, Mr. Big (Chris Noth). On Feb. 18, Page Six published a report that Noth would not be joining the reboot. But let's not take Page Six at their word just yet, because Noth has been dropping some clues on social media.
"Everything changes—including announcements in the rags," he wrote.
If you look at Noth's Instagram comments, they are filled with pleads from fans to bring back Mr. Big. Guess we have to wait!
The story will follow Carrie, Miranda, and Charlotte in their 50s.
We last saw the friends in 2010, so more than a decade has passed in the friends' lives. That goes back to what Bloys said about the women's friendship with Samantha. It's been a long time, everyone is in their 50s, and friendships fall off. What else is going on with the group now that they're 50? Surely they've picked up some quarantine hobbies. The real question is whether we could ever see Carrie becoming a sourdough aficionado.
The franchise is used to spin-offs.
This is definitely not the first time the SATC creators have expanded the universe. If you'll recall, The CW had a series called The Carrie Diaries based on Candace Bushnell's prequel to her 1997 Sex and the City book. The show, which starred AnnaSophia Robb, ran from 2013 to 2014.
Of course, there were also two feature films, Sex and the City (2008) and Sex and the City 2 (2010). Will we ever see the end of these friends, this show, and Carrie Bradshaw? Not if fan power has anything to say about it. That said, if you don't have an HBO Max subscription, it's time to get on it.
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