text:
package edu.mayo.phenoportal.server.authentication;

import java.sql.Connection;
import java.sql.PreparedStatement;
import java.sql.ResultSet;
import java.util.Date;
import java.util.logging.Level;
import java.util.logging.Logger;

import javax.servlet.http.HttpSession;

import com.google.gwt.user.server.rpc.RemoteServiceServlet;
import edu.mayo.phenoportal.client.authentication.AuthenticationService;
import edu.mayo.phenoportal.server.database.DBConnection;
import edu.mayo.phenoportal.server.utils.DateConverter;
import edu.mayo.phenoportal.server.utils.SmtpClient;
import edu.mayo.phenoportal.shared.MatImport;
import edu.mayo.phenoportal.shared.User;
import edu.mayo.phenoportal.shared.database.UserColumns;
import edu.mayo.phenoportal.utils.SQLStatements;
import edu.mayo.phenoportal.utils.ServletUtils;

public class AuthenticationServiceImpl extends RemoteServiceServlet implements
        AuthenticationService {

    private static Logger s_logger = Logger.getLogger(AuthenticationServiceImpl.class.getName());
    private static final long serialVersionUID = 1L;

    // TODO CME - this needs to be changed to 0 to not enable the user by
    // default
    // Change when we get the admin page set up to enable a user.
    public static final int DEFAULT_USER_ENABLED = 1; // enable is true
    public static final int DEFAULT_USER_ROLE = 3;

    public static final String USER = "user";

    @Override
    public User authenticateUser(String userName, String pw) throws IllegalArgumentException {

        String sessionId;

        // get the user from the DB. User will be null if user is invalid.
        User user = getUser(userName);

        // check the pw from the user obtained from the db. Validate it is
        // correct.
        if (user != null) {
            boolean valid = BCrypt.checkpw(pw, user.getPassword());

            if (valid) {
                // check for null user - send up user/pass does not exist
                sessionId = getCurrentSessionId();
                setSessionForUser(user);
                user.setSessionId(sessionId);
            } else {
                // if the pw is invalid, set the user object to null
                user = null;
            }

        } else {
            user = null;
        }

        return user;
    }

	public User validateImportUser(MatImport matImport) {
		String sessionId;

		User user = getUser(matImport.user);
		if (user != null) {
			sessionId = getCurrentSessionId();
			setSessionForUser(user);
			user.setSessionId(sessionId);
		}
		return user;
	}

    @Override
    public User isValidSession() throws IllegalArgumentException {
        HttpSession httpSession = getThreadLocalRequest().getSession(true);
        return (User) httpSession.getAttribute(USER);
    }

    @Override
    public void terminateSession() throws IllegalArgumentException {
        HttpSession httpSession = getThreadLocalRequest().getSession(true);
        httpSession.invalidate(); // kill the session
    }

    private String generateHashPw(String pw) {
        return BCrypt.hashpw(pw, BCrypt.gensalt());
    }

    /**
     * get the user's session id
     *
     * @param user
     * @return
     */
    private void setSessionForUser(User user) {

        HttpSession httpSession = getThreadLocalRequest().getSession(true);
        httpSession.setAttribute(USER, user);
    }

    /**
     * Get the user's current session. May be null.
     *
     * @return
     */
    private String getCurrentSessionId() {

        HttpSession httpSession = getThreadLocalRequest().getSession(true);
        return httpSession.getId();
    }

    @Override
    public Boolean registerUser(User user) throws IllegalArgumentException {
        return setUser(user);
    }

    @Override
    public Boolean updateUserPassword(User user) throws IllegalArgumentException {

        Connection conn = DBConnection.getDBConnection();
        PreparedStatement st = null;
        ResultSet rs = null;

        boolean success = false;

        if (conn != null) {
            try {

                // need to store the hashed password
                String pwHashed = generateHashPw(user.getPassword());

                // update the user values
                st = conn.prepareStatement(SQLStatements.updateUserPasswordStatement(
                        user.getUserName(), pwHashed));

                st.executeUpdate();
                success = true;

            } catch (Exception ex) {
                s_logger.log(Level.SEVERE, "Failed to update user password" + ex.getMessage(),
                        ex);
            } finally {
                DBConnection.closeConnection(conn, st, rs);
            }
        }

        return success;
    }

    /**
     * Gets the User information based on the userName. If the returned user is
     * null, then the user/pass combo does not exist in the database It's always
     * good to check for null. If the returned User is not null, it will contain
     * all the information
     *
     * @param name
     * @return
     */
    private User getUser(String name) {
        Connection conn = DBConnection.getDBConnection();
        PreparedStatement st = null;
        ResultSet rs = null;
        User user = null;

        if (conn != null) {
            try {

                // get the user based on the user name. we will check the pw
                // later
                st = conn.prepareStatement(SQLStatements.selectUserStatement(name));
                rs = st.executeQuery();

                if (rs.next()) {
                    user = new User();

                    user.setUserName(rs.getString(UserColumns.USER.colNum()));
                    user.setLastName(rs.getString(UserColumns.LNAME.colNum()));
                    user.setFirstName(rs.getString(UserColumns.FNAME.colNum()));
                    user.setEmail(rs.getString(UserColumns.EMAIL.colNum()));
                    user.setPassword(rs.getString(UserColumns.PASS.colNum()));
                    user.setRole(rs.getInt(UserColumns.ROLE.colNum()));
                    user.setEnable(rs.getInt(UserColumns.ENABLE.colNum()));
                    user.setRegistrationDate(rs.getString(UserColumns.REGISTRATIONDATE.colNum()));
                }
            } catch (Exception ex) {
                s_logger.log(Level.SEVERE,
                        "Failed to get users for Authenticating" + ex.getMessage(), ex);
            } finally {
                DBConnection.closeConnection(conn, st, rs);
            }
        }
        return user;
    }

    /**
     * Enters User information into the database.
     *
     * @param user
     * @return
     */
    private boolean setUser(User user) {
        Connection conn = DBConnection.getDBConnection();
        PreparedStatement st = null;
        ResultSet rs = null;
        boolean isSuccessful = false;

        String pwHashed = generateHashPw(user.getPassword());

        if (conn != null) {
            try {
                long registrationDate = System.currentTimeMillis();
                user.setRegistrationDate(DateConverter.getTimeString(new Date(registrationDate)));
                st = conn.prepareStatement(SQLStatements.insertUserStatement(user, pwHashed));

                st.execute();
                sendRegistrationEmail(user);
                isSuccessful = true;
            } catch (Exception ex) {
                s_logger.log(Level.SEVERE, "Failed to Set users in database" + ex.getMessage(),
                        ex);
                isSuccessful = false;

            } finally {
                DBConnection.closeConnection(conn, st, rs);
            }
        }
        return isSuccessful;
    }

    private void sendRegistrationEmail(User user) {
        String host = ServletUtils.getSmtpHost();
        String from = ServletUtils.getSmtpFromAddress();
        String messageText = ServletUtils.getEmailContentsUserRegistration();
        String port = ServletUtils.getSmtpPort();
        String pw = ServletUtils.getSmtpPassword();

        SmtpClient.sendRegistrationSuccessEmail(host, from, pw, port, messageText, user);
    }

}

redpajama_set_name: RedPajamaGithub


Great for team building, birthday parties (young and old!), and girls nights out, our workshops are tons of fun! Be prepared to get your hands dirty, learn a wealth of botanical knowledge, and take home your botanical masterpiece. All private workshops are held at the shop after store hours.
Price: Base price starts at $385 plus tax for up to 6 guest.
Length: 2 hours including workshop instruction and any time needed by guests to customize the space for your celebration.
Availability: 7 days a week after store hours.
Please accompany your keiki under 10 years of age unless otherwise noted.
To schedule, contact Paiko by email at hello@paikohawaii.com or by phone at (808) 988-2165. A non-refundable 50% deposit is required to book a workshop and reserve the date. Balance is due 3 days prior to the event.
Additional Workshop Time: If you need to rent the space for additional time you can do so at the rate of $75 per additional hour.
$100 an hour with a 2 hour minimum. An additional instructor and travel fee is required for workshops conducted outside of Paiko.
Paiko reserves the right to substitute our plants, materials, and vessels due to the availability of supplies throughout the seasons.


As IT infrastructure continues to evolve, it is pretty clear that the line between servers and storage systems is continuing to blur. Arguably, the process started with the advent of network-attached storage (NAS) systems that some would say are little more than server nodes on the network with some shared storage attached.
With the advent of virtualization, things got even fuzzier when multiple application workloads on the same server began accessing pools of virtual storage resources that the application treated as one logical entity. Now comes the rise of caching and in-memory computing and suddenly there are multiple tiers of computing and storage resources that all need to be much more dynamically orchestrated.
According to Sean Moser, vice president of GSSD software product for Hitachi Data Systems (HDS), it's this ongoing convergence of server and storage systems that has led HDS to enter the server market. As enterprise computing continues to evolve, Moser says the distinction between servers and storage systems will increasingly fade away.
In fact, Moser says many of the principles that unified the management of data and storage on mainframe systems are now being applied to distributed systems. What's really changed is that distributed systems now have the memory capacity and virtualization technologies needed to support much more sophisticated approaches to managing data.
It may still take a few years for all this convergence to play out, but once it does, it has some fascinating implications for companies such as EMC and NetApp that make most of their money selling storage systems. If the distinction between servers and storage continues to fade away, either those companies will have to find their way into the server business or be acquired with somebody who already is. Of course, EMC has already aligned itself with Cisco in a joint venture that tightly couples its storage systems to Cisco servers. But at this point, any storage system can be attached to a Cisco server equally well, so it will be interesting to see how that alliance evolves over time.
In the meantime, the convergence of distributed servers and storage systems might actually just be part of a larger trend that is driving the convergence of mainframe and distributed computing systems. That will probably take even longer to fully play out, even though there are examples of it today. The one thing that is for certain is that in a few years what we call a server or storage system today is going to look very different.


text:
FeaturesCracking the Collection
Cracking the Collection: October
Cracking the Collection, Featured, Features
I got well ahead of the game this month and watched all three titles in my challenge in the middle of September. I've only just got around to reviewing them though, so these write-ups might be a bit brief and vague. I don't make notes when I watch these.
October ended up being a strong selection of films, possibly the strongest so far. Below are my thoughts on the titles:
Nominated by Jim Whalley
I've wanted to watch this for a long time as I like Robert Altman and have a soft spot for these type of large ensemble dramas with several interwoven storylines. The length has always put me off though (it's a little over 3 hours long), so I'm very happy that Jim picked this for me to finally watch. I'm particularly happy as it ended up being as great as I'd heard and hoped. The cast is incredible for one. I'm not sure I've ever seen a stronger line-up of actors in one film and they all deliver top notch performances. Tim Robbins has possibly the most memorable role as a deplorable husband, father and cop. He plays it big, which could have resulted in being hammy, but it serves to make his character look childish and pathetic whilst he parades around trying to lord it over everyone.
The huge array of storylines are well balanced too and none feel disposable. They only loosely tie together towards the end, but thematically they work beautifully as one, forming an examination of life, love and death in L.A. The spectre of death looms particularly large as we're regularly told about potentially carcinogenic spray being used across the state to tackle a Medfly infestation. The way one or two of the stories tie up is slightly unsatisfying and an earthquake effect in the finale is a little shoddy, but these are very minor criticisms in an otherwise superb film.
Nominated by Rob Smith
State of Grace is a film that got slated on its original release, but has developed a few admirers over the years, so I was keen to see for myself. Although not at the scale of Short Cuts, State of Grace also has an excellent cast that includes Sean Penn, Ed Harris, Gary Oldman, Robin Wright, John Turturro and a young John C. Reilly. The former three are the leads and are playing to type for the most part, but do so with great aplomb. Also playing to type so to speak is the plot, which is a typical undercover cop/mobster affair which offers few surprises. However, it's very well put together, letting the cast showcase their skills whilst offering up some slick cinematography and an excellent final gun fight. The whole film is played very big, so some might find it a bit over the top, but if you're a fan of a grand, stylish crime thriller, you're in for a treat.
Nominated by Mikaela Smith
The Act of Killing was a film I was simultaneously very interested in and also a bit scared of watching. I'd heard it was deeply disturbing and I find such documentaries far more troubling than horror fiction films because you don't have that "it's only a movie" safety net. However, the film was chosen so I braved it. I'm glad I did too, as it was fantastic. Yes, the film is terrifying in letting former Indonesian death-squad leaders unflinchingly discuss their mass-killings, then re-enact them in the film genres of their choice, but I found myself more stunned and fascinated by their reactions than physically disgusted. I was surprised to find the film spends little time going into the politics of Indonesia and exactly what happened there and why, instead focussing solely on the perpetrators of the murders and how they're dealing with what they did, almost 50 years later. The handful of people director Joshua Oppenheimer speaks to all deal with it very differently too, with some convincing themselves they did right, whilst the most closely followed subject, Anwar Congo, seems rather cold about it all. That is until the final scenes, which are astonishing. I don't want to say too much in case you've not seen the film, but the finale to this has to be seen to be believed. It's one of the most powerful sequences of documentary filmmaking I've ever seen. The whole thing is fascinating, original, incredibly brave and highly recommended. I need to see the follow-up now, The Look of Silence.
Up next in November:
The Awful Truth – Nominated by Andrew Goulding, Jim Whalley
The Great Escape – Nominated by Jason Cluitt
The Ipcress File – Nominated by Adam Goulding
Editor of films and videos as well as of this site. On top of his passion for film, he also has a great love for music and his family.
The Great Blueprint: Review Survey
Spoiler Episode 10 – Ready Player One
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redpajama_set_name: RedPajamaCommonCrawl


At the shrine of Onitama, two schools fight, only this time it is different. Now the Wind Spirit can change the game. Here's our Way of the Wind review.
Pocket Mars describes itself as a heavy weight filler. Set on the Red Planet, this little game has a lot to offer including interesting hand management.
Where the Tiger pounces, the Kirin restricts the opposition. Let's look at one of the most interesting cards (and strategies) in Onitama: Sensei's Path.
Sensei's Path is an expansion to the hit abstract game Onitama. It adds 16 new cards to the game, including Turtle, Phoenix, and Kirin. Here's our review.
Elegant and colourful, Sagrada is a game with an unusual theme that has taken the gaming world by storm. It's fantastic. Here's our Sagrada Review.


text:
Wilmington Apple
#1 Online News Source For Wilmington, MA
by Robert Hayes
5 Things To Know In Wilmington On Wednesday, October 14, 2020
WILMINGTON, MA — Below are 5 things to know in Wilmington on Wednesday, October 14, 2020:
#1) Watch Wilmington School Committee Meeting
The Wilmington School Committee meets at 7pm in the High School's Large Instruction Room. (Executive Session begins at 6pm). Residents are asked to watch via WCTV. Read the agenda HERE.
#2) Watch Wilmington Housing Authority Meeting
The Wilmington Housing Authority meets at 5:30pm via GoToMeeting. Read the agenda HERE.
#3) Watch Wilmington Board Of Appeals Meeting
The Wilmington Board of Appeals meets at 7pm via Zoom. Read the agenda HERE.
#4) Wilmington Library Hosts 'Wicked' Author Gregory Maguire In Conversation With Lemony Snicket
The Tewksbury Public Library and Wilmington Memorial Library have joined forces to host bestselling author Gregory Maguire in conversation with bestselling author Daniel Handler (aka "Lemony Snicket") for a Zoom webinar on Wednesday, October 14, 2020 at 7pm.
Maguire will discuss the 25th Anniversary of Wicked: The Life and Times of the Wicked Witch of the West, and his latest book, A Wild Winter Swan.
Space is limited. Registration is required and can be found at www.tinyurl.com/gregorytalkswicked.
While this virtual event is completely free, attendees can purchase an autographed copy of the book to be shipped to their homes from the event's bookstore partner – Wellesley Books. Wicked can be purchased at www.tinyurl.com/buywicked. A Wild Winter Swan can be purchased at www.tinyurl.com/buyawildwinterswan.
Gregory Maguire is the New York Times bestselling author of Confessions of an Ugly Stepsister; Lost; Mirror Mirror; and the Wicked Years, a series that includes Wicked, Son of a Witch, A Lion Among Men, and Out of Oz. Now a beloved classic, Wicked is the basis for a blockbuster Tony Award–winning Broadway musical. Maguire has lectured on art, literature, and culture both at home and abroad. He also helped found and for 25 years codirected Children's Literature New England, Inc., a nonprofit that raises awareness of the significance of literature in the lives of children. He lives with his family near Boston.
After brilliantly reimagining the worlds of Oz, Wonderland, Dickensian London, and the Nutcracker, the New York Times bestselling author of Wicked turns his unconventional genius to Hans Christian Andersen's "The Wild Swans," transforming this classic tale into an Italian-American girl's poignant coming-of-age story, set amid the magic of Christmas in 1960s New York. As he explores themes of class, isolation, family, and the dangerous yearning to be saved by a power greater than ourselves, Gregory Maguire conjures a haunting, beautiful tale of magical realism that illuminates one young woman's heartbreak and hope as she begins the inevitable journey to adulthood.
Daniel Handler is the author of seven novels. As Lemony Snicket, he is responsible for numerous books for children, including Swarm of Bees, illustrated by Rilla Alexander. His books have sold more than 70 million copies and have been translated into 40 languages, and have been adapted for screen and stage. The first season of Netflix's adaptation of A Series of Unfortunate Events, for which he served as Executive Producer and Writer, won a 2018 Peabody Award for its "lively excellence, strange silliness, and compelling storytelling," and the teleplay won a 2019 Writers Guild Award. He lives in San Francisco with the illustrator Lisa Brown, to whom he is married and with whom he has collaborated on several books, and one son.
This event is sponsored by a collection of North of Boston libraries, including the Memorial Hall Library in Andover, Flint Memorial Library in North Reading, Tewksbury Public Library, Wilmington Memorial Library, and Woburn Public Library.
This event is a part of a series of virtual discussions with bestselling authors these libraries are holding this fall. Their next virtual event will take place on Monday, October 26 at 7pm with Karen Kingsbury, who will be discussing her brand new book — Truly, Madly, Deeply.
#5) Library Event: Time For Twos
This 10am storytime for two year olds includes books, rhymes, music and movement. Zoom Meeting Room invitations will be emailed to registered attendees at least one hour before the event. Register HERE.
Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple's daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email wilmingtonapple@gmail.com.
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Hi! Sign in to let us know how Providence Christian School was?
by Hillary54 at Citysearch Nov 10 .
They did not seem to care about my child. They have so many children that you get lost. I want more child focused care.
I moved him to a different place.
If you've been to or used Providence Christian School, leave a review.


- Should you train each muscle 1, 2, or 3 times a week?
3, 2, or 1 workout a week per muscle to build muscle faster?
How many workouts a week to build muscle as fast as possible, based on a 2016 meta-analysis by Schoenfeld et al.
Non-responders actually responded to exercise when volume was increased (2 more sessions a week). Study done on cardio, but should apply to weight training, in principle.
Results: The Estimated Average Requirement (EAR) of protein and the upper 95% CI RDA for these young male bodybuilders were 1.7 and 2.2 g ⋅ kg−1 ⋅ d−1, respectively.
Bret Contreras' best (according to him) guide to bigger glutes.


Argentinian authorities claim to have new evidence implicating top Iranian officials in the deadly bombing in 1994 of a Jewish center in Buenos Aires. Here's a look at Argentina's claims and the Islamic republic's alleged role in the attack.
Russia's S-300 missile system could dramatically change the stakes in the Syrian conflict if it is sent to Damascus, which Russia has signed a contract to do. RFE/RL correspondent Charles Recknagel lays out five things to know about the air-defense system.
U.S. authorities say Alimzhan Tokhtakhunov is a crime boss who should be jailed for 90 years on charges of laundering money and running an illegal gambling business. But in Moscow, where he lives 100 meters from the Kremlin, the man reputed to be one of the last surviving Soviet-era gangsters scoffs at the allegations –- and the authorities certainly aren't giving him problems. RFE/RL gets an audience with Tokhtakhunov, aka "Taiwanchik."
Kyrgyz officials have declared a state of emergency in the district surrounding the Canadian-owned Kumtor gold mine, which has been the target of massive protests by locals claiming the mine has poisoned their drinking water. The government itself has accused the mine of environmental violations and has used the issue to demand a new contract with the owners, Centerra Gold. But what's really known about the environmental impact of the mine?
Belgium's postal service says media reports in Azerbaijan about what was essentially a vanity stamp of the late President Heydar Aliyev gave the wrong impression.
The lifting of U.S. sanctions on the export to Iran of communication tools has been welcomed by activists and groups who had pushed for such a move and argued that the sanctions end up hurting ordinary Iranians, not the regime.
The top United Nations human rights expert has called for a global pause on developing and deploying killer robot soldiers, known as "lethal autonomous robots," or LARs.
The Kyrgyz parliament is calling for the ouster of nearly a dozen high-ranking officials who they say orchestrated the release of a Chechen criminal boss from jail. Aziz Batukaev was freed from Naryn prison and flown to Chechnya in April after Kyrgyz officials ruled he was suffering from leukemia and required urgent medical treatment. But Kyrgyz lawmakers now say Batukaev's illness was a ruse, and have presented pictures of the crime boss smoking and enjoying a sumptuous meal while in prison.
It was one year ago that Kazakh authorities announced a mass murder at a distant outpost on the Kazakh-Chinese border. Since then, the sole surviving border guard has been convicted and jailed, but many questions remain unanswered.
Turkmenistan shows little tolerance for Islamists as it tries to guard against the extremism that bedevils other Central Asian states. But will its tough approach sow the seeds for future problems?
The death of Wali-ur Rehman Mehsud, the Pakistani Taliban's second-in-command who was reportedly killed in a drone strike early on May 29, would be a major blow to the extremist movement operating in Pakistan and Afghanistan. RFE/RL looks at the potential impact of the unconfirmed killing.
The U.S.-based NGO Human Rights Watch has slammed Azerbaijan for arresting political opponents on spurious drugs charges in the run-up to the country's October presidential election. But it seems Baku is not alone in apparently using such tactics to muzzle dissent.


We love to see you smile. Really, we do. That's because we take great pride in offering the most up-to-date family and cosmetic dental techniques in a relaxed, friendly atmosphere, served up by one of the most knowledgeable and experienced general dentists in the field. We know that every great smile--your smile--is the sign that we've done our job to provide the highest level of care in the industry.
Dentistry has advanced by leaps and bounds over the years. Gone are the procedures of old that delivered substandard results. Now, almost anything can be accomplished with the right technology and know how. We use the latest technology, and are thoroughly trained in the latest techniques. That, combined with our unwavering commitment to you, results in an experience that's unlike any other in the dental field. You'll immediately feel at ease, and our initial consultation will help you map out a complete dental plan that achieves superior results.


text:
The New Day Make History At WWE NXT Deadline
By Lyle Kilbane. Published 11th December 2022.
The New Day duo of Kofi Kingston and Xavier Woods will find themselves in the record books in WWE once again just a few weeks after the team's longest tag team title reign in WE history was overtaken by The Usos.
Woods and Kingston left it late to be a part of the NXT Deadline event but it turned out to be better late than never for the experienced team as they challenged Pretty Deadly for their NXT Tag Team Championship. The New Day proved to be too much for Elton Prince and Kit Wilson as they left the event as the new NXT Tag Team Champions.
The New Day are the third triple crown tag team champions in WWE history
With that win, it puts The New Day in rarefied air in WWE's tag team division as they have become only the third team in company history to win all of the NXT, Raw, and SmackDown Tag Team Championships, and the first to complete the triple crown by winning the NXT title last.
The Revival was the first team to complete the tag team triple crown, winning the NXT Tag Team Championship back in October 2015 and capturing the Raw and SmackDown titles at different times in 2019. The Street Profits also achieved the feat and are so far the team to have done so in the quickest time with their three title wins coming within sixteen months.
The New Day first captured the Raw Tag Team Championship when it was simply known as the WWE Tag Team Championship at Extreme Rules in April 2015 from Cesaro and Tyson Kidd. In total, the team that also included Big E has held that title four times.
The group has captured the SmackDown Tag Team Championship on seven different occasions with the first of those wins coming back in July 2017.
It remains to be seen how long The New Day will continue to be a part of WWE's developmental brand but with several new tag teams for them to face in NXT, their reign as champions could be another long one.


Intel just detailed their new lineup of SoCs targeted at lower priced systems and laptops. These chips, belonging to the Gemini Lake family, will succeed the current Braswell generation. Together with the new architecture, that promises better IPC performance, they will come with increased clock speeds, most significantly the boost frequencies.
While Intel mentions an increased performance of 58% you'll have to take a look at the fine print to see that that isn't referring to the previous architecture but rather to the Pentium N3540 (Released in July 2014).
According to the already accessible details in Intels ARK database those chips will support up to 8GB of DDR4 memory, 3 displays and offer 4K support at 60Hz. Even though Intel, in the announcement, mentions the importance of WiFi that will be offered with all new processors that leaves out the part about the need for a so called Companion RF (CRF) Module needed to actually use the wireless Options. So a Pentium N5000 only holds the CNVi portion of the package and does not guarantee WiFi capability. That depends of the manufacturer of the system and the presence of the CRF module. So you still have to check the feature list to make sure.
While all of those chips were launched just yesterday Intel expects mayor retailers to start shipping their systems in Q1 '18.


text:
Grant Neely
Arpan Kohli
Neostigmine is water-soluble, an ionized compound that reversibly inhibits the enzyme acetylcholinesterase. Its FDA indication is for the reversal of the effects of non-depolarizing neuromuscular blocking agents after surgery. The use of neostigmine is primarily found in the context of the reversal of neuromuscular blockade during the administration of anesthesia to patients undergoing surgery that require muscle relaxation. After administration of neostigmine, the concentration of acetylcholine is increased in the neuromuscular junction which allows for muscles to contract with full strength and patients can breathe spontaneously and protect their airways safely after emergence from anesthesia.[1][2][3]
Mechanism of Action
Acetylcholine is the neurotransmitter in the body that is made, stored, and released by the end of motor nerve terminals. Acetylcholine is metabolized by an enzyme called acetylcholinesterase that hydrolyzes acetylcholine in the neuromuscular junction. Neostigmine one of the drugs in the class of acetylcholinesterase inhibitors. Neostigmine is an oxy-diaphoretic inhibitor of the acetylcholinesterase enzyme, which means that it binds and inhibits via acid-transferring (or binding to the anionic site of the enzyme creating a covalent bond). Neostigmine inhibits acetylcholinesterase, which is the enzyme that metabolizes acetylcholine into choline and acetic acid. This allows acetylcholine to build up at the neuromuscular junction and overcome the competitive inhibition of nondepolarizing blocking drugs. It is used to accelerate the reversal of nondepolarizing neuromuscular blockade of nicotinic receptors in the neuromuscular junction at the end of surgery. Neostigmine is a quaternary ammonium compound that does not penetrate the blood-brain barrier.[4][5][6]
Peripheral nerve stimulator should be utilized to determine when neostigmine dosage should be initiated and for the administration of subsequent doses. Neostigmine should be administered when the first twitch response of a peripheral nerve stimulator is substantially greater than 10% of baseline, or when a second twitch is present. The drug is administered intravenously as a bolus. The drug is administered intravenously as a bolus. Intravenous (IV) dosage is 0.03 mg/kg to 0.07 mg/kg (up to 5 mg), with the higher dose for first twitch responses that are close to but not substantially greater than 10%. The peak effect (antagonism) occurs at approximately 7 to 10 minutes, and the duration of action is approximately 55 to 75 minutes. The principal route of excretion is the kidney. Neostigmine is typically administered along with an antimuscarinic agent like glycopyrrolate or atropine to attenuate the parasympathomimetic activity at other non-muscular acetylcholine receptor sites.[7][8]
Pediatric administration: Neostigmine is considered the drug of choice for routine practice in the reversal of neuromuscular blocking agents in the pediatric population. This is due to a greater final recovery from a blockade in comparison to edrophonium. The elimination half-life of neostigmine is less in children, but distribution volumes are similar in infants, young children, and adults. As in adults, the speed of onset of antagonism is dependent on the degree of neuromuscular blockade at that time; however, the dose requirements are slightly less in children when compared to adults. If the pediatric patient has a train-of-four response with fade, a dose of 20 micrograms per kilogram of neostigmine, followed by 10 micrograms to 20 micrograms per kilogram of atropine or 5 micrograms to 10 micrograms per kilogram of glycopyrrolate is sufficient to achieve reversal of neuromuscular blockade and return of adequate muscle strength.
There are a number of adverse effects of neostigmine that can affect multiple organ systems, most of which are related to the cholinergic side effects of the drug. Cardiac muscarinic effects that can be seen include bradyarrhythmias like junctional escape rhythms, complete heart block, and even asystole. A potential life-threatening adverse effect of neostigmine is bronchoconstriction. Neostigmine, along with other anticholinesterase inhibitors, can stimulate the muscarinic receptors in the airway smooth muscle which can lead to bronchospasm. This adverse effect can be mostly attenuated with concurrent administration of an anticholinergic agent like glycopyrrolate. Other adverse effects include increased secretions, miosis, nausea, and increased peristalsis. The majority of these effects can be minimized by concurrent dosing of an anticholinergic drug with a similar onset time, typically glycopyrrolate. In pregnancy, neostigmine can cross the placenta and cause fetal bradycardia and concurrent administration of atropine, which also crosses the placenta, should be considered in this situation. Another significant side effect of neostigmine and other anticholinesterase inhibitors is paradoxical anticholinesterase-associated muscle weakness. The clinical manifestation of muscle weakness include decreases in upper airway dilator muscle tone, impairment of respiratory muscles like the diaphragm, and reductions in minute volume which is the tidal volume multiplied by the respiratory rate.
Absolute contraindications of neostigmine include a hypersensitivity to neostigmine, and peritonitis or mechanical obstruction of the intestinal or urinary tract. Neostigmine should also not be administered if zero twitches are observed on a peripheral nerve stimulator after administration of a nondepolarizing neuromuscular blocking drug. Neostigmine should be used with caution in patients with coronary artery disease, cardiac arrhythmias, recent acute coronary syndrome, and myasthenia gravis.
It is important to consider the relative duration of action of neuromuscular blocking agents when administering neostigmine as a reversal agent. Administering neostigmine after a relative degree of spontaneous recovery of neuromuscular function is important to prevent "recurarization," which can manifest itself as increased weakness in the post-operative recovery unit due to the lasting effect of the neuromuscular blocking drug. Of note, up to 70% of acetylcholine receptors may still be blocked with an apparently normal train of four from the peripheral nerve stimulator. The duration of action of neostigmine is increased in patients with renal failure as it is excreted by the kidneys.
Ways to use acetylcholinesterase reversal agents to reduce the risk of residual neuromuscular blockade:
Train-of-four counts less than one or no response. Do not use neostigmine for reversal of neuromuscular blockade. Wait until train-of-four count is greater than one.
Train-of-four count of two or three. Administer the proper dose of Neostigmine (or another acetylcholinesterase inhibitor) and extubate when adductor pollicis train-of-four ratio is 0.9 or greater.
Train-of-four count is greater than 0.4. Administer a moderate dose of neostigmine and extubate when adductor pollicis train-of-four ratio is 0.9 or greater.
Train-of-four count greater than 0.7. Avoid using neostigmine as the risk of anticholinesterase induced muscle weakness is greater.
Overdosage of neostigmine can cause a cholinergic crisis which is described as increased muscle weakness and may result in death due to the involvement of respiratory muscles. If this occurs, the immediate use of atropine should be administered.
Neostigmine is primarily used by the anesthesiologist, anesthesia nurse, emergency department physician, and the intensivist. The patient must be monitored after administration of neostigmine as it can induce cholinergic side effects that can affect many organ systems. Besides bradycardia, a potentially life-threatening adverse effect of neostigmine is bronchoconstriction. ICU nurses and anesthesiologists should regularly monitor vital signs after neostigmine has been administered. When given to patients with myasthenia gravis, the lowest dose should be used and gradually titrated upwards depending on the response.
[1] Nair AS, Questions Regarding the Use of Neostigmine-Atropine to Treat Postdural Puncture Headache. Anesthesia and analgesia. 2019 Apr 3; [PubMed PMID: 30973380]
[2] Kim NY,Koh JC,Lee KY,Kim SS,Hong JH,Nam HJ,Bai SJ, Influence of reversal of neuromuscular blockade with sugammadex or neostigmine on postoperative quality of recovery following a single bolus dose of rocuronium: A prospective, randomized, double-blinded, controlled study. Journal of clinical anesthesia. 2019 Mar 30; [PubMed PMID: 30939422]
[3] Franz A,Chiem J,Martin L,Rampersad S,Phillips J,Grigg E, Case Series of 331 doses of Sugammadex compared to Neostigmine in patients under 2 years old. Paediatric anaesthesia. 2019 Apr 1; [PubMed PMID: 30934160]
[4] Pakala RS,Brown KN, Cholinergic Medications 2019 Jan; [PubMed PMID: 30844190]
[5] Luo J,Chen S,Min S,Peng L, Reevaluation and update on efficacy and safety of neostigmine for reversal of neuromuscular blockade. Therapeutics and clinical risk management. 2018; [PubMed PMID: 30573962]
[6] Neostigmine 2006; [PubMed PMID: 30000438]
[7] Adeyinka A,Kondamudi NP, Cholinergic Crisis 2019 Jan; [PubMed PMID: 29494040]
[8] Tajaate N,Schreiber JU,Fuchs-Buder T,Jelting Y,Kranke P, Neostigmine-based reversal of intermediate acting neuromuscular blocking agents to prevent postoperative residual paralysis: A systematic review. European journal of anaesthesiology. 2018 Mar; [PubMed PMID: 29189420]
Take 9 Question Quiz on Neostigmine


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Our own ice cream parlour has been refurbished and can now tempt you with genuine Italian ice cream, delicious, fresh crepes, and the Chocolate Fantasy: a stick with delicious fruit dipped in a thick layer of wonderful chocolate.
Look forward to visiting Lalandia in Billund and experience our new market square. The sky over the square is always a wonderful blue.


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Beautiful and really well made. My husband bought it as a first anniversary gift and I loved it!


THE MISSION is excited to announce an exhibition of recent work by Matt Magee and Glen Hanson at INDE/JACOBS in Marfa, TX. A site-specific wall mural by Magee will featured in the show. The exhibition will be onview through Monday, May 29, 2017.


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Le Kiosk raising €5.6 million to make bundled tablet mags social
Robert Andrews Nov 14, 2012 (Jun 9, 2020) -- Blog Post
Earlier this summer, I wrote about Le Kiosk, a French start-up trying to bring an a la carte tablet magazine subscription buffet to the UK, France and Italy.
Now Le Kiosk is taking a €5.6 million ($7.1 million) second-round investment to add social features and Windows 8 apps for its system, and to expand to more countries.
Currently operating in France and — since June — the UK, Le Kiosk charges £10 or £10 per month for access to a 10-title magazine bundle. Co-founder Michael Philippe tells me Le Kiosk:
"We have had over 700,000 downloads of our app, there are around 30,000 subscribers to our 10-magazine bundle and we have 100,000 paying active users on the platform. We had €1.4 million revenue last year – and around €6 million this year."
Now Le Kiosk is getting the Italian launch Philippe promised earlier. And Philippe says the company needed to take money "to fuel our growth and global expansion and to invest in product development".
Specifically, Le Kiosk, which is currently on iOS and Android, wants to build a Windows 8 version, wants to develop methods to make its magazine portfolio more readable on smaller, 7-inch phablets, wants to get more publishers aboard and wants to socialise the titles.
"Putting social interactions in to our app is our main development for next year," Philippe said. "We need to go further and bring interactivity, interactions between our readers. We are also working on new ways to read the text on smaller screens."
Le Kiosk as the current buzzphrase goes, "skeumorphic" — which is to say, the app UI mimics a French sidewalk newsstand
The new money is coming from two French investors — CM-CIC Capital Privé, which has previously backed Deezer and Spartoo, and the government-backed CDC Entreprises.
Although Le Kiosk claims titles from all major French publishers, that is not the case in the UK.
"The goal is to secure all the major publishers," Philippe concedes. "In the UK, it is important to improve the bundle. We still don't have all the publishers in the bundle."
Philippe reckons Le Kiosk's benefit is encouraging discovery in a market whose consumers are often fiercely locked to their favourite titles.
"Eighty-five percent of subscribers are subscribing to magazines they would never had read in paper or digital without the bundle," Philippe says.
It is, as the current buzzphrase goes, "skeumorphic" — which is to say, the app UI mimics a French sidewalk newsstand
Europe, Media, Technology


Tai-chi is one of the ways of keeping fit while aging.
Dr. Elizabeth Phelan, director of the Fall Prevention Clinic at UW Medicine Harborview, spoke to Molly Shen with KOMO-TV on the importance of exercise as we age.
"Even in late life, people can benefit greatly from actually starting, Phelan said. It's never too late to start a balance program, for example."
In addition to strength and balance, the National Institute on Aging recommends people work on flexibility and endurance, as part of the Go4Life program.


text:
Essay on Africa
Profile Of One Of The Worlds Greatest Thinkers: Mohandas Gandhi Essay Example
Topic: Africa, India, Democracy, Life, Civil Rights, Violence, England, Freedom
A game changer in the modern world in the origins of political struggle has been the ability of enacting political changes vianon-violent struggle. From apartheid in South Africa, to the Velvet Revolution of Czech, to the Civil Rights movement in The United States, to non-violent struggle for freedom led by Mohandas Gandhi, it has change the very nature of what concerned citizens can accomplish through. As a leader and inspiration of this movement, Mohandas Gandhi is not just an important thinker for India. His influence has affected governments and promoted freedom across the globe and the change his ideas lead to have continued after his death.
Mohandas Gandhi was born in Porbandar Bombay in 1860 to the father of a high Hindu servant cases. In line with the tradition at the time, he was married off to a 14 year-old girl Kasurbai when he was only thirteen. Death of those hin his family plagued him early on as Ghandi's father died when he was 16 years old and he last his first child that same year who died at only 3 days old, although he would eventually go on to have four sons.
After he graduated from high school in 1887 he sold his wife's dowry jeweler and went to England to study to be a lawyer, but took a vow to lead a monastic existence there eating no meat, drinking no alcohol and not enjoying the company of women.
Racism was not something he was familiar with and he was shaken by his first encounter with not being allowed to travel in the first class by rail or book the hotel he desired because of his race. This spurred something in him, which would continue throughout his entire life.
In his autobiography, "My Experiments With Truth," Ghandi writes about how his non-violent form of struggle, while novel at the time, was carefully though and planned. He writes, "I cannot attain freedom by a mechanical refusal to act, but only by in intelligent action in a detached manner" (Gandi, 20).
This biography lays out Gandhi's own struggles with figuring out his p,ace and life. This give image of a man who is not always convinced that he is beyond equivocation, but has faith in the process of lettings his his thoughts grow like seeds to action action and fostering an axiom belief that his beliefs stemmed from noble intention. It also shows Ghandi's profound interest in other philosophies and religion. He writes, "I intend to make a careful study of my own religion and, as far as I can, of other religions as well" (Gandhi, 18).
Gandhi first began his public career as a civil rights advocate in South Africa where he began meeting with other Indians and defending their rights. IN 1894 he founded the INC (Indian Natal Congress), which was a movement directed at procuring the fill rights for Indians living in South Africa.
When he finally returned India in 1915, he was fully engaged and completely aligned in the effort of obtaining civil rights for Indians. His leadership had grown by 1918 when he began more controversial work of organising strikes against landlords and protests against taxation from the British.
His protest was marked with his brand of compassion for even those whom he fought against. Again from his autobiography, "I hope God will give me the courage and the sense to forgive them and to refrain from bringing them to law" (Gandhi, 144).
1919 marks a turning point in the fight against the British when the Amristar Massacre had British soldiers firing on a gathering of Indians at a religious festival killing nearly 1,000. This was a significant date in the in the struggle for civil rights, but not a change in Ganhi's method.
Despite his own methods of non-violence and understanding, he spent some of his life in jaily, serving two years for sedition in 1922 and afterwards staying out of active politics until the new decade. One of the non-violent actions he was most famous for was when he marched with 100,000s to a costal village of Dandi to protest a British tax enacted on the production of salt. He boiled water and encouraged others to do so to obtain their own salt from the sea. This led to more than half of those participating being imprisoned. All were soon released in agreement that they would suspend civicl disobedience and Gandhi was finally recognized as a party to deal with and invited to Britain for talks.
Gandhi's example and life would continue until his assassination in 1948. Sadly and ironically, this pioneer of non-violence met a violent end when a hindu nationalist who disagreed with is policy on Pakistan killed him before he was going to address a prayer meeting.
Ghandi's legacy will certainly live on as it has, in giving those seeking justice a voice and method to bring about freedom and rights without resorting to violence.
" Mahatma Gandhi Biography - Facts, Birthday, Life Story - Biography.com ."Famous Biographies & TV Shows - Biography.com . N.p., n.d. Web. 17 Apr. 2013. .
"BBC - History - Historic Figures: Mohandas Gandhi (1869 - 1948)." BBC - Homepage. N.p., n.d. Web. 17 Apr. 2013. .
Desai, Mahadev H.. Gandhi's autobiography: the story of my experiments with truth. Washington, D.C.: Public Affairs Press, 1948. Print.
Example Of Essay On Encounter And Confrontation
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Home > 106th Congressional Public Laws > Pub.L. 106-282 Making further continuing appropriations for the fiscal year 2001, and for other purposes. <> ...
Pub.L. 106-282 Making further continuing appropriations for the fiscal year 2001, and for other purposes. <> ...
<DOC>
[[Page 114 STAT. 865]]
Public Law 106-281
To amend the National Housing Act to temporarily extend the
applicability of the downpayment simplification provisions for the FHA
single family housing mortgage insurance program. <<NOTE: Oct. 6,
2000 -  [H.R. 5193]>>
United States of America in Congress <<NOTE: FHA Downpayment
Simplification Extension Act of 2000.>> assembled,
SECTION 1. <<NOTE: 12 USC 1701 note.>> SHORT TITLE.
This Act may be cited as the ``FHA Downpayment Simplification
Extension Act of 2000''.
SEC. 2. EXTENSION OF APPLICABILITY OF DOWNPAYMENT SIMPLIFICATION
Subparagraph (A) of section 203(b)(10) of the National Housing Act
(12 U.S.C. 1709(b)(10)(A)) is amended by striking ``executed for
insurance in fiscal years 1998, 1999, and 2000'' and inserting ``closed
on or before October 30, 2000''.
Approved October 6, 2000.
LEGISLATIVE HISTORY--H.R. 5193:
CONGRESSIONAL RECORD, Vol. 146 (2000):
Sept. 19, considered and passed House.
Sept. 28, considered and passed Senate.
Other Popular 106th Congressional Public Laws Documents:
1 P.R. 013 () For the relief of Saeed Rezai. <> [Document Status (Version] ...
2 Pub.L. 106-248 To authorize the acquisition of the Valles Caldera, to provide for an effective land and wildlife management program for this resource within the Department of Agriculture, and for other purposes. <> %%Filen...
3 Pub.L. 106-031 Making emergency supplemental appropriations for the fiscal year ending September 30, 1999, and for other purposes. <> ...
4 Pub.L. 106-065 To authorize appropriations for fiscal year 2000 for military activities ...
5 Pub.L. 106-197 To exempt certain reports from automatic elimination and sunset pursuant to the Federal Reports Elimination and Sunset Act of 1995, and for other purposes. <> ...
6 Pub.L. 106-093 Waiving certain enrollment requirements for the remainder of the first ...
7 Pub.L. 106-286 To authorize extension of nondiscriminatory treatment (normal trade relations treatment) to the People's Republic of China, and to establish a framework for relations between the United States and the People's Republic of China. <
8 Pub.L. 106-191 To amend the Mineral Leasing Act to increase the maximum acreage of Federal leases for sodium that may be held by an entity in any one State, and for other purposes. <> ...
9 Pub.L. 106-452 To redesignate the facility of the United States Postal Service located at 2339 North California Avenue in Chicago, Illinois, as the ``Roberto Clemente Post Office''. <> ...
10 Pub.L. 106-139 To amend the Immigration and Nationality Act to provide that an adopted alien who is less than 18 years of age may be considered a child under such Act if adopted with or after a sibling who is a child under such Act. <
11 Pub.L. 106-449 To modify the date on which the Mayor of the District of Columbia submits a performance accountability plan to Congress, and for other purposes. <> ...
12 Pub.L. 106-512 Providing for conveyance of the Palmetto Bend project to the State of Texas. <> ...
13 Pub.L. 106-196 To designate the United States courthouse located at 223 Broad Avenue in Albany, Georgia, as the ``C.B. King United States Courthouse''. <> ...
14 Pub.L. 106-540 Making further continuing <> appropriations for the fiscal year 2001, and for other purposes. ...
15 Pub.L. 106-299 To amend the Wild and Scenic Rivers Act to designate the Wekiva River and its tributaries <> of Wekiwa Springs Run, Rock Springs Run, and Black Water Creek in the State of Florida as components of the nati...
16 Pub.L. 106-356 To amend the Dayton Aviation Heritage Preservation Act of 1992 to clarify the areas included in the Dayton Aviation Heritage National Historical Park and to authorize appropriations for that park. <> %%Fil...
17 Pub.L. 106-494 To provide for the conveyance of certain land to Park County, Wyoming. <> ...
18 Pub.L. 106-557 To amend the Magnuson-Stevens Fishery Conservation and Management Act to eliminate the wasteful and unsportsmanlike practice of shark finning. <> ...
19 Pub.L. 106-354 To amend title XIX of the Social Security Act to provide medical ...
20 Pub.L. 106-106 Making further continuing appropriations for the fiscal year 2000, and for other purposes. <> ...
21 Pub.L. 106-536 To amend the Immigration and <> Nationality Act to provide special immigrant status for certain United States international broadcasting employees. ...
22 Pub.L. 106-413 To increase, effective as of December 1, 2000, the <> rates of compensation for veterans with service- connected disabilities and the rates of dependency and indemnity compensation for the survivors of cert...
23 Pub.L. 106-128 To direct the Secretary of the Interior to make corrections to a map relating to the Coastal Barrier Resources System. <> ...
24 Pub.L. 106-430 To require changes in the bloodborne pathogens standard in effect under the Occupational Safety and Health Act of 1970. <> ...
25 Pub.L. 106-559 To provide technical and legal assistance to tribal justice systems and members of Indian tribes, and for other purposes. <> ...
26 Pub.L. 106-048 To designate the Federal building and United States courthouse located ...
27 Pub.L. 106-176 To <> make technical corrections to the Omnibus Parks and Public Lands Management Act of 1996 and to other laws related to parks and public lands. ...
28 Pub.L. 106-203 To designate the Federal building and United States courthouse located at 1300 South Harrison Street in Fort Wayne, Indiana, as the ``E. Ross Adair Federal Building and United States Courthouse''. <> %%File...
29 Pub.L. 106-503 To authorize appropriations for the United States Fire Administration, and for carrying out the Earthquake Hazards Reduction Act of 1977, for fiscal years 2001, 2002, and 2003, and for other purposes. <> %...
30 Pub.L. 106-446 To amend title 10, United States Code, to facilitate the adoption of retired military working dogs by law enforcement agencies, former handlers of these dogs, and other persons capable of caring for these dogs. <
106th Congressional Public Laws Records and Documents


Dr Neslyn Watson-Druée, CBE – She is a renowned Professional International Speaker, Executive Coach – Best 100 Global Coaching Leader, Award Winner of Women of the Decade in Community Leadership & Social change.
Dr Neslyn has influenced pioneering developments with Government, British NHS, entrepreneurial and community development. Dr Neslyn articulates the behaviours and characteristics of successful leaders. Her unique business system The Leaders' Code™ is used in corporate organisations to change organisational culture, demonstrate courage, show commitment, develop creativity, challenge issues and care about people.
You know when you when you have passion and drive to design your life and business to respond to what gives you joy? When you have a yearning and desire to set yourself up for success along with a desire, passion and fire in your belly to be a great leader, to lead your life and business fervently, to be an authentic, courageous, and confident leader, to be your full potential? That is what I do. I enable leaders to be courageous, authentic, confident, to be their full potential and leave a legacy.
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Yellowstone season 5 episode 8: The likely cliffhanger
Yellowstone December 26, 2022
As so many of you are most likely aware at this point, Yellowstone season 5 episode 8 is set to arrive this weekend on Paramount Network. Due to the Christmas holiday, there was no installment last night.
What can we say about the story ahead? Well, the stakes have never been higher for John Dutton when you consider the problems that surround him in all directions. For starters, he has to concern himself with Jamie and Sarah Atwood's efforts to unseat him as Governor, and that's without even mentioning the crisis underneath the surface with the wolves or the state of his cattle, which he has to migrate elsewhere with the help of the bunkhouse.
SUBSCRIBE to Matt & Jess on YouTube now for new Yellowstone videos!
So amidst all of this, is there one specific cliffhanger that you can probably expect? Well, we tend to think that the most likely scenario here is that John's status as Governor is in some sort of legitimate danger — and with that, so is the ranch's future. It's possible that Taylor Sheridan could put a character's life into jeopardy, but we wonder if he'd do that given the huge cliffhanger at the end of the season 3 finale. Most writers choose to not repeat themselves, since they'd like to create a few other intriguing scenarios instead. The ranch is a character itself, so putting it in a certain degree of danger absolutely makes for compelling entertainment in its own way.
Technically, there is no 100% guarantee that we're going to get a cliffhanger at the end of this … but we'd be honestly surprised if there isn't. This is the sort of show that loves and embraces this sort of thing much of the time!
Related – Be sure to see some other news on Yellowstone now, including what else could be coming down the road
What sort of cliffhanger are you expecting to see after Yellowstone season 5 episode 8?
Share right away in the comments! Once you do just that, remember to come back for other updates you don't want to miss. (Photo: Paramount Network.)


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Excellent general purpose screen printing photostencil capillary film for medium/fine mesh counts.
MacDermid Autotype offeres a range of heat stabilised polyester films with low residual shrinkage.


Biology tells us everyone's got a difference tolerance for heights and other scary things. Whether it's your Aunt Agnes who can barely step near a balcony's edge or your daring friend who casually flirts with death on daily free climbs, we all look like terrified cats stuck in a tree when James Sight from ILLSIGHT tackles the towering King's Hill crane in vertically-ambitious Hong Kong! We shiver to think what it would take to give this daredevil sweaty palms.


text:
By Samhita • 8 years ago
That Awful Moment when the House implicitly endorses violence against women
House Republicans have stooped low in their all-out war on women by turning an issue that has never been bipartisan–that violence against women is a bad thing–into a partisan one voting 222-206 in support of a ridiculous, callous and watered down version of the Violence Against Women Act. As Vanessa noted Tuesday, it was slated to be voted on Wednesday with the hope that they wouldn't pass the watered down version the House produced–but we should only be so hopeful.
This bill denies protection of undocumented immigrants, Native/indigenous people and LGBT victims of violence. Distinguishing these populations that are actually highly vulnerable and susceptible to violence is uniquely callous. What could motivate such thinking? Well, Amanda looked through the list of lobbyists in support of this particular version of the bill and let's just say–they are exactly the kind of people that would love to legalize violence against women.
She writes at Pandagon,
Prior to this year, even Republicans by and large felt that tacitly endorsing moderate levels of wife-beating was a bridge too far, but since their new motto is, "Bitches: Fuck 'Em", I suppose this sort of thing was inevitable. Right Wing Watch has a piece up about the lobbyists who influenced this vote. These lobbyists, led by the anti-victim group Concerned Women for America, is a real cadre of hateful people. The coalition released a letter supporting the watered-down bill, and it was signed by a rather notorious wife-beater who ran for office by claiming his ex-wife endorsed him, which she did not. There's also a group that represents men who purchase mail order brides. They're concerned that the bill would allow women who have been secured through their services to divorce husbands who beat them without being deported. (A favorite tactic of abusers is to marry immigrants, often secured through these services, and then terrorize them with the threat of deportation if they don't take their beatings like good girls.) These are the people that the Republicans are listening to.
Only a party desperately clinging to any semblance of relevance would allow this kind of thinking to make it this far in the legislative process. You can't give MRA's the light of day–they are called trolls for a reason!
Twenty-three House Republicans voted against the bill, 6 democrats voted for it and the White House has said they will veto the house version if it makes it to the President's desk. Via.
Samhita
Read more about Samhita
Trump to Appoint Anti-Feminist To Key Women's Rights Position
How anti-trans bathroom arguments exploit fear of sexual violence to push bigotry
By Alyssa Peterson
In case it needs to be said: Planned Parenthood is not illegally selling fetal tissue
Trump intends to nominate a woman named Penny Young Nance as ambassador-at-large for global women's issues. As such, she'd be responsible for managing the State Department's programs to fight gender-based violence and promote women and girls' educational and economic achievement.
Here's the problem: Penny Young Nance has made her career standing in the way of girls' and women's rights.
Nance is the President and CEO of Concerned Women For America (CWA), an organization whose mission statement says it "protects and promotes Biblical values and Constitutional principles" in America. The group is as far-right as it gets, and Nance is basically a bargain Phyllis Schlafly — a reactionary zealot ...
Trump intends to nominate a woman named Penny Young Nance as ambassador-at-large for global women's issues. As such, she'd be responsible for managing the State Department's programs to fight gender-based violence ...
By Alyssa Peterson • @alysspeterson • 5 years ago
Ed. note: This post was originally posted on the Community site.
Last week, Houston voters rejected the Houston Equal Rights Ordinance (HERO), a measure that would have provided for comprehensive nondiscrimination protections for the lesbian, gay, bisexual, and transgender, or LGBT, community along with a number of other marginalized groups. Although this bill's aim — protection from discrimination — was straightforward, as Jos covered last week, it came under fire from conservative groups who subjected Houston voters to an intense misinformation campaign.
Acting through a front group known as the Campaign for Houston, conservatives focused in on the ordinance's protections for transgender Houstonians, and in particular, the law's coverage of public spaces like restaurants, stores, or hotels. While HERO ...
Last week, Houston voters rejected the Houston Equal Rights Ordinance (HERO), a measure that would have provided for comprehensive nondiscrimination protections for the lesbian, gay, bisexual, and ...
The latest undercover "sting" video seeking to discredit Planned Parenthood is here. In this selectively edited video, a group called the Center for Medical Progress charges that the reproductive health clinics are "selling" fetal tissue and organs.
The person behind the Center for Medical Progress, a group of self-described "citizen journalists" monitoring medical ethics which didn't seem to be doing much until it launched its "investigation" into Planned Parenthood, is the former research director for Live Action, the anti-choice group that put out similarly misleading videos targeting the organization over sex-selective abortions and sex-trafficking.
As in the previous videos, this latest "exposé" exposes no evidence of any scandal. As Planned Parenthood explained in a statement:
conservatives▪VAWA▪wingnuts


Liverpool, UK, May 30, 2015 – Alcon, the global leader in eye care and a division of Novartis, announced the results of a new in vitro study on wetting substantivity effects of AOSEPT® PLUS with HYDRAGLYDE® Moisture Matrix. The study results will be presented at the 2015 Annual Conference of the British Contact Lens Association, May 29-31, in Liverpool, UK. The study shows AOSEPT PLUS with HYDRAGLYDE Moisture Matrix technology reconditions silicone hydrogel (SiHy) lenses and provides superior wetting substantivity compared to the commercially available hydrogen peroxide products evaluated.
"Our challenge was to synthesize a novel compound within the HYDRAGLYDE Moisture Matrix technology family that was compatible in a hydrogen peroxide system and that would provide improved wetting substantivity as well as re-conditioning of contact lenses," said Dr. Leroy Muya, Sr. Research Scientist, Alcon Vision Care. "We are pleased as a team to have been successful in doing so and providing this next generation product."
Three SiHy contact lens types were evaluated for wetting substantivity via the sessile drop technique after multiple disinfection cycles using the manufacturer-recommended regimen. Six commercially available hydrogen peroxide solutions were tested, including AOSEPT PLUS with HYDRAGLYDE. Contact angle measurements were obtained after multiple disinfection cycles in order to capture changes in contact angle over time.
Results concluded all SiHy lenses soaked in AO SEPT PLUS with HYDRAGLYDE Moisture Matrix were associated with a statistically significant lower contact angle compared to lenses treated in all five commercially available hydrogen peroxide products (p< 0.01). Depending on the SiHy lens material, these contact angle measurements were between ~20-70° higher than lenses cycled in AOSEPT PLUS with HYDRAGLYDE. Additionally, the contact angle of lenses treated in AOSEPT PLUS with HYDRAGLYDE Moisture Matrix both before and after equilibration in saline was less than or equal to the contact angle of the same lens out-of-pack.
"For many silicone hydrogel materials, maintaining wetting substantivity over the course of the replacement cycle is challenging. AOSEPT PLUS with HYDRAGLYDE Moisture Matrix technology is an excellent new cleaning and disinfecting solution that uniquely helps maintain wetting substantivity," said Dwight Akerman, OD, FAAO, FBCLA, Head of Global Professional Affairs for Alcon.
The AOSEPT PLUS Cleaning & Disinfecting Solutions with HYDRAGLYDE Moisture Matrix technology (CLEAR CARE PLUS in some markets) contains 3% hydrogen peroxide and is indicated for use with soft (hydrophilic) and rigid gas permeable (RGP) contact lenses. During the cleaning process, the hydrogen peroxide is neutralized in the special lens case provided to leave behind a preservative-free saline solution that is gentle on the eyes. Cleaned and disinfected lenses can be stored in the neutralized solution in the unopened lens case up to seven days.
AOSEPT PLUS with HYDRAGLYDE Moisture Matrix technology requires patients to follow special cleaning and disinfecting instructions, including ensuring the lenses remain in the special lens case for at least six hours to allow the hydrogen peroxide to neutralize. Special care is needed to follow directions to avoid accidental misuse.
Alcon, the global leader in eye care, provides innovative products that enhance quality of life by helping people worldwide see better. Alcon's three businesses, Surgical, Pharmaceutical and Vision Care, offer the widest spectrum of eye care products in the world. Alcon is the second largest division of the Novartis Group, with pro-forma sales of USD 10.8 billion in 2014.


VicMan Software Users Community • View topic - reloading pictures?
Hey... really love the screensaver!
Is there some way to respawn all the pictures in a particular gallery from within the screensaver? After about 5 minutes of viewing the same pictures, it can get a little boring. If not, maybe this is an idea for the next revision of the program!
hello! we're thinking about it. When all changes in the program (in the next release) will be finally approved, we announce about it in the Forum.
It would be awesome if there would be some way of reloading more pictures . The constant repetition gets boring , and I have found this is the major problem with all flash based picture galleries.


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The inline speed skating events at the 2009 World Games in Kaohsiung was played between 17 and 19 July. Sixty roller skaters, from 18 nations, participated in the tournament. The competition took place at Yangming Skating Rink.

Participating nations

Medal table

Events

Men

Women

References

External links
 World Skate
 Roller sports on IWGA website
 Results
 Entries

2009 World Games
2009

redpajama_set_name: RedPajamaWikipedia


text:
Recent Appearance: Red's First Steps: Page 15
by Carlos on June 15, 2021 at 2:35 AM
Characters: Fingers, Henry Thornton, Mary Thornton, Mickey, Tiffany "Red" Thornton
Ok, let's get to it. Why is the page so late this time? Well, multiple reasons.
It's true that I had a complicated weekend, with the usual suspects like connections issues, IRL business, and some old fashioned procrastination that I am fully responsible for. But in truth, I also had some writer's block on this one. Transition pages aren't always easy. You need them to link important events together, but the fact that there isn't much going on within them makes them a difficult beast.
I originally had a different page planned, which was a little more mean spirited, but I scrapped that to show a different side of Mary. We know by now what intentions Mary has for her new daughter in the present, but I wanted to show that she would still react like any other mother to this kind of event, at first. At least, I think this should be about right.
None the less, I'm truly sorry about the delay. The next page should be posted Sunday, to give this page some time to breath. After that, everything should be back on schedule.
└ Tags: Fingers, Henry, Mary Thornton, Mickey, Red
Poor Red, even when his mom is trying to be a mother, she is just too handie.
"That man"? Would Henry be referring to Clarence's biological father?
Also, "The Don"? Either Henry actually IS a Mob leader, or he likes to give the image of being so.
Hey Veny go snatch this Jeanie girl and bring her here.
I mean, he could be a professor at the University of Oxford in the UK. They are called Dons, for some reason. Does Henry do a lot of traveling? Maybe he is lecturing at Oxford? I'm going with that until proven otherwise, just because that would be funnier.
June 15, 2021, 1:56 PM	| #
Also, noble landholders in Spain and its American possessions were called Dons (e.g. Don Diego de la Vega in "Zorro"). Given that they live in Southern California, Henry could be calling himself a Don because his direct ancestor was one of these 19th century landowners.
He could also be referring to Red's grandfather. Red overheard Henry instructing someone to investigate someone she called "Gramps" as she entered the room. Whether that's Reds maternal, paternal or even honorary grandfather has not been explained.
Given that the man to be investigated has the surname "Walsh", which is Mary's maiden name, then it is probably a relative of hers.
it's ok Carlos, I understand. Red really wants to tell her folks what happened, but she doesn't know if they'll believe her. also, what could Red's mom be hiding about Southeil.. and why does she want Red to take her place there?
We already know what Mary intention are once she got use to the idea that her son is now her daughter. She want her daughter to take her place in the Southeil school for girls where they recruit girls into being witches. She want to do with Tiffany what she could not do herself, but, now she get a second chance to do it through Tiffany her new daughter. After a few days, Mary is perfectly on board with the idea of her son being her daughter and probably doesn't want Tiffany going back to being her son now again.
Personally, I would like to see more back story on Tiffany before going back to the future like, seeing her doing exhibitions of female clothing for teenage girls. Mary sending Tiffany to girls finishing school to teach girl how to think and act like ladies. By the time we go back to the future from when she was 15 years old in 9th grate to becoming 16 years old in 10th grade, we can see all the things that she put through. All those things that she is being put through would affect her thinking and would have gotten to her to make her think more like a girl and less like a guy.
Corlys
Most likely if Henry sent his goons after Jeannie she'd probably turns them into chicks too
Only if they are competent enough to actually find her.
Really, only parents handling their son becoming daughter correctly are Dunkels. https://www.egscomics.com/comic/2002-06-18
Could kazum have a love child?
Although it might be possible for Kazum to have a love child, I doubt that he has one and Clarence or Tiffany is him or her. Nice try, but, probably not.
So you're retconning Red's mom being abusive?
Not really. I have mention this before, but on the original run, we only had a single page to figure out Mary's character, alongside some of Red's later commentary about her. Both of which seemed to contradict the character's bio ("Mary is an intelligent, beautiful woman who found herself the trophy wife of a prominent Hollywood producer. With her son transformed into a female, she sees it as a happy situation that could possibly bring them closer to each other.") And her original appearance on JB. With that said, I haven't really retcon anything about her, other than giving her the single mother background now.
She seems far nicer now, and she is in a better mood than during her first time in the comic, but outside this initial shock towards Clarence transformation, she has only show to take advantage of the situation, impose her will over the one of her child, seemingly manipulate her husband to play along, and intimidate Helga to do her biding. It all depends of how you define "abusive", still, let me be clear, there is a lot more to Mary's character and story than what we have seen so far.
Actually, Melvin Chronicle, really needed to be broken up into about six to ten section or more Arc to be told properly. That way you can concentrate on different part of the story and the different characters in the story. As it is right now, it kind of disjointed and hard to follow. There a lot of flipping back and forth between character otherwise.


Sri Venkateswara College of Pharmacy was initiated under the prestigious Srinivasa Educational Academy and runs with the objective of providing quality education to the deserving candidates in the field of pharmacy and makes students competent through skill development. The college has been excelling at developing the overall persona of student and instilling the education and knowledge with the global outlook and state of the art facilities. The college helps develop the awareness of the latest technologies by the research facilities and the laboratories. In a nutshell SVCP is a right place to acquire knowledge, improve and hone skills with positive attitude.
Pharmacy Practice Department – With more than 350 beds to provide training to students while studying to help understand and nurture basic skills.
Coaching & Placements – The College provides training and sessions for exams like GPAT, NIPER, PGECET, IELTS, etc.
UGC Approved Research Centre – The College is affiliated to the research centre and instils the skills and dedication required in students interested in research.


We are happy to announce our newly re-vamped website! For 2019, we decided it was time for a whole new look!
If you have rescued or adopted a new dog, thank you! Here are some tips to help your dog to adjust and feel at right home.
At Peninsula Critter Care, we love animals of many kinds. We encourage rescuing, fostering, and adopting pets from shelters.
Having your pet(s) meet with your pet sitter ensures that they will not be shocked or frightened when service begins.
Peninsula Critter Care is your locally owned and operated San Mateo, California pet sitting service.


The Refine Edge tool, which adds crazy good soft edge matting to the already amazing Roto Brush.
Snapping. This doesn't sound big, but it actually is. Make a cube in seconds rather than minutes.
Read more here. And here's a good rundown of what's new in Premiere—looks like they focused on solid usability features rather than glitz, which is great to see.
Now, back to After Effects. Cinema 4D Lite will be bundled with this "next" version, and you'll be able to create a C4D scene right from within AE. You create the 3D animation in C4D, but you can change your view on the scene using the AE camera. Then, when you render your After Effects project, the C4D scene is rendered on-the-fly. This is not just a welcome simplification of the standard render-import-render workflow, it puts powerful 3D features into any After Effects session. Pretty cool.
Creative Cloud subscribers will get these new features as soon as they are released, which, I suspect, will create a lot of warm, fuzzy feelings about the whole software-as-a-subscription model.
A big, personal congrats to my friends on the After Effects team. Nice work all!


Welcome to the Java Kanji Flashcards homepage. This Java applet will help you learn the 500 most commonly occuring Japanese Kanji. If you would like to use an online dictionary to learn more and study other Kanji, please try Kiki's Kanji Dictionary which has thousands more Kanji, definitions, and compounds in an easy to use, browsable dictionary format.
An illustration of the KanjiCard applet in action.
You can learn about this project in our Introduction .
If you are already familiar with this program, you can use the Flashcards online.
For a tutorial introduction and documentation, please read the Help pages.
If you would like to print out paper versions of the Kanji Flashcards, please start Printing .
For developer and researcher credits, papers, grants, and links to related projects, please check our References page.
Don't like frames? Have a small screen? Please select the Non-Frames version of this site.
The Java Kanji Flashcard 500 project was made possible by grants from the Japan Foundation Assistance Program for the Development of Japanese-Language Teaching Recourses and the DePaul Univerisity Quality of Instruction Council and DePaul University Academic Technology Development. The flashcard database was developed with data from Asashi Newspaper Inc. (Asahi Shinbun-sha) and is used with permission.


text:
Custom Art Category
Art Pictures
music-blog
Cooking Blog
Food Before
Food After
Recommended Food
Open Cooking
Art is a diverse range of human activities in creating visual, auditory or performing artifacts (artworks), expressing the author's imaginative, conceptual idea, or technical skill, intended to be appreciated for their beauty or emotional power.[1][2] In their most general form these activities include the production of works of art, the criticism of art, the study of the history of art, and the aesthetic dissemination of art. Music, theatre, film, dance, and other performing arts, as well as literature and other media such as interactive media, are included in a broader definition of art or the arts.[1][3] Until the 17th century, art referred to any skill or mastery and was not differentiated from crafts or sciences. In modern usage after the 17th century, where aesthetic considerations are paramount, the fine arts are separated and distinguished from acquired skills in general, such as the decorative or applied arts. Though the definition of what constitutes art is disputed[4][5][6] and has changed over time, general descriptions mention an idea of imaginative or technical skill stemming from human agency[7] and creation.[8] The nature of art and related concepts, such as creativity and interpretation, are explored in a branch of philosophy known as aesthetics.[9]
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'); is_agreed=false; } } else{ is_agreed=true; } if(isvalidName==true && isvalidEmail==true && is_agreed==true){ $n(".AjaxLoader").show(); $n('#mysuccess_msg').html(''); $n('#mysuccess_msg').hide(); $n('#myerror_msg').html(''); $n('#myerror_msg').hide(); var name=""; if($n('#yourname').length >0){ name =$n("#yourname").val(); } var nonce ='783d49e838'; var url = 'https://www.rawbit.org/wp-content/plugins/email-subscribe/'; var email=$n("#youremail").val(); var str="action=store_email&email="+email+'&name='+name+'&is_agreed='+is_agreed+'&sec_string='+nonce; $n.ajax({ type: "POST", url: 'https://www.rawbit.org/wp-admin/admin-ajax.php', data:str, async:true, success: function(msg){ if(msg!=''){ var result=msg.split("|"); if(result[0]=='success'){ $n(".AjaxLoader").hide(); $n('#mysuccess_msg').html(result[1]); $n('#mysuccess_msg').show(); setTimeout(function(){ $n.fancybox_ns.close(); },2000); } else{ $n(".AjaxLoader").hide(); $n('#myerror_msg').html(result[1]); $n('#myerror_msg').show(); } } } }); } }
Thanks all you music & divers, Hope you had a good time and contact by e-mail for any [email protected] Dismiss


text:
Harvard University uncovers DNA switch that controls genes for whole-body regeneration
Sarah Knapton
A piece of non-coding DNA may hold the key to how humans could regenerate body parts
Humans may one day have the ability to regrow limbs after scientists at Harvard University uncovered the DNA switch that controls genes for whole-body regeneration.
Some animals can achieve extraordinary feats of repair, such as salamanders which grow back legs, or geckos which can shed their tails to escape predators and then form new ones in just two months.
Planarian worms, jellyfish, and sea anemones go even further, actually regenerating their entire bodies after being cut in half.
Now scientists have discovered that that in worms, a section of non-coding or 'junk' DNA controls the activation of a 'master control gene' called early growth response (EGR) which acts like a power switch, turning regeneration on or off.
"We were able to decrease the activity of this gene and we found that if you don't have EGR, nothing happens," said Dr Mansi Srivastava, Assistant Professor of Organismic and Evolutionary Biology at Harvard University.
Jellyfish have extraordinary powers of regeneration Credit: REX/Shutterstock
"The animals just can't regenerate. All those downstream genes won't turn on, so the other switches don't work, and the whole house goes dark, basically."
The studies were done in three-banded panther worms. Scientists found that during regeneration the tightly-packed DNA in their cells, starts to unfold, allowing new areas to activate.
But crucially humans also carry EGR, and produce it when cells are stressed and in need of repair, yet it does not seem to trigger large scale regeneration.
Scientists now think that it master gene is wired differently in humans to animals and are now trying to find a way to tweak its circuitry to reap its regenerative benefits.
Post doctoral student Andrew Gehrke of Harvard believes the answer lies in the area of non-coding DNA controlling the gene. Non-coding or junk DNA was once believed to do nothing, but in recent years scientists have realised is having a major impact.
"Only about two percent of the genome makes things like proteins," added Mr Gehrke said. "We wanted to know: What is the other 98 percent of the genome doing during whole-body regeneration?
"I think we've only just scratched the surface. We've looked at some of these switches, but there's a whole other aspect of how the genome is interacting on a larger scale, and all of that is important for turning genes on and off."
Marine animals, such as the moon jellyfish, are masters of regeneration and some have been found to clone themselves after death.
In 2016, a Japanese scientist reported that three months after the death of his pet jellyfish, a sea anemone-like polyp rose out of the degraded body, and then astonishingly aged backwards, reverting to a younger state.
In the 1990s, scientists in Italy discovered that the Turritopsis dohrnii jellyfish switches back and forth from being a baby to an adult, resulting in its nickname, the immortal jellyfish.
Dr Srivastava added: "The question is: If humans can turn on EGR, and not only turn it on, but do it when our cells are injured, why can't we regenerate?" added Dr Srivastava.
"It's a very natural question to look at the natural world and think, if a gecko can do this why can't I?
"The answer may be that if EGR is the power switch, we think the wiring is different. What EGR is talking to in human cells may be different than what it is talking to in the three-banded panther worm."
The research was published in the journal Science.
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Trump administration carries out 13th and last execution
The Trump administration early on Saturday carried out its 13th federal execution since July, an unprecedented run that concluded just five days before the inauguration of President-elect Joe Biden, who is an opponent of the federal death penalty.
Federal law enforcement hasn't had to use significant legal and technical resources at its disposal because of online documentation.
Texas realtor charged after taking private jet to Capitol riot says she regrets nothing
In a freewheeling and at times combative interview with NBC News, Jenna Ryan said she has no regrets about participating in the Capitol incursion.
Trump 'won't pardon himself or family', says Fox News
An 'influential' Palm Beach eye doctor is reportedly on Trump's clemency list
Former Trump campaign spokesman claims the only reason the president isn't denouncing the Capitol riot more is because Twitter and Facebook banned him


EA provide site service, deliveries and collections using its dedicated fleet of vehicles. The fleet, which ranges from vans to HGV trucks with on-board cranes, has been chosen specifically to offer unrivalled response times and capacity to customers. .
All our vehicles are maintained to the highest standards and regularly renewed, we have stringent policies in place regarding vehicle operation and all drivers are trained and tested to ensure compliance.
EA operate a documented and formal Transport policy. EA employ the services of an independent Health, Safety and Risk management consultancy to ensure all systems and procedures are up to date and in line with current legislation and best practice.
EA use traffic management to ensure all loading and unloading operations are conducted safely.
EA's trucks are fitted with Palfinger hydraulic cranes to allow quick, safe and accurate unloading.
Where not practical to use the on-board crane fork lift trucks are used to ensure efficient loading and maximum use of available bed space.


text:
PMR Researcher Findings Lead To Phase II Clinical Trials
Drs. Joe E. Springer and James W. Geddes investigated the neuroprotective effects of the drug riluzole in spinal cord injury (SCI) models several years ago, and this drug in now the process of being translated into a phase II clinical trial. Drs. Springer and Geddes were the first to investigate the neuroprotective properties of riluzole, a glutamate release inhibitor, in a rat SCI model showing that it could prevent secondary injury mediated by the proteolytic enzyme calpain. Dr. Springer's lab then went on to do additional work including a demonstration that the combination of riluzole and high dose methylprednisolone, the latter having been the unofficial standard of care in acute SCI since 1990, could produce a better outcome than either treatment alone in regards to improving functional recovery.
Subsequent to this experimental work, Dr. Michael Fehlings, Professor of Neurosurgery at the University of Toronto and a leading clinical investigator in the SCI field, became interested in riluzole and after confirming the UK work in his own laboratory has organized a multicenter phase II clinical trial to assess the safety and efficacy of riluzole treatment in acute SCI patients.
A major advantage to riluzole is that it is already a marketed drug that is sometimes used to slow the progression of amyotrophic lateral sclerosis (ALS) with a proven safety record. In fact, it was Dr. Springer's original interest in ALS, a neurodegenerative disease affecting motor neurons that first led him to hypothesize that riluzole might also be useful in acute SCI. Moreover, as noted above, it appears to complement the use of high dose methylprednisolone setting up the possibility of combination therapy with the two agents.
Resident Research
Research Day 2016 Photos
Research Meeting Photos
Stroke and Spinal Cord Neurorehabilitation Research
Equipment and Techniques
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Formed in 2009, the 5 piece rock group continues to wow audiences at shows all across Minnesota. With a great blend of keys, bass, drums, two guitars and vocals, the group's dynamics and depth in music are impressive, and always leave audiences wanting more.
Yasen Marie is an all-woman, all-power musical force to be reckoned with from Minneapolis, MN. Comprised of a group of vibrant women with a dream, they bring their electrified live show from state to state, coast to coast, dazzling audiences with unique grooves that'll make your body move.


text:
Finchley Methodist Church is a Methodist church in Ballards Lane, North Finchley, London.

See also
East Finchley Methodist Church

References

External links

Methodist churches in London
Finchley


Amanda Phingbodhipakkiya is a Creative Director, Design Strategist and creator of Beyond Curie, a design project that highlights the rich history of women in science, technology, engineering and mathematics. The idea behind Beyond Curie is to remind us all about women whose achievements in science, engineering and mathematics changed the world we live in today.
This design project has been recognized all over the world and Museeum's goal is to introduce you a wonderful woman behind it. We asked Amanda to curate this Reading List that we now share with you. This woman has a lot to say! Enjoy.
"These books have helped shape my strategic thinking, inspired me to create new work and purposefully approach projects and relationships with collaborators and colleagues in new ways."
To call out a few of them: "Power: Why Some Have It and Others Don't" by Stanford professor Jeffrey Pfeffer, has given me incredible insights into how to leverage my skills, talent, and relationships to create work that matters. There is a fine line between creativity and chaos and because I feel that I often veer close to crossing that line, "Messy: The Power of Disorder to Transform Our Lives" by Tim Harford has been very self-affirming. I've also begun to read "Quiet: The Power of Introversion in a World that Can't Stop Talking" by Susan Cain. As an introvert and former woman in science, I appreciate how she expertly weaves neuroscience, anecdotes, and advice on how to harness the power of being an introvert."