text:
DTW in Cython
=============

Easy to use Dynamic Time Warping in Cython. You can set your own distance in
`_example_dist.pyx` by respecting the function name and the type.

[![DOI](https://zenodo.org/badge/doi/10.5281/zenodo.45257.svg)](http://dx.doi.org/10.5281/zenodo.45257)

Dependencies:
 - Cython
 - Numpy
 - (optional) Matplotlib

Use/test:

    (optional) cython -a dtw/_dtw.pyx && open dtw/_dtw.html
    python -c "import pyximport; import numpy as np;\
    pyximport.install(setup_args={'include_dirs':[np.get_include()]});\
    import dtw; dtw._dtw.test()"

Install:

    make install

See `dtw.DTW(...)` and `dtw._dtw.test()` for the usage of the DTW function.

I keep `DTW_a` and `DTW_f` separated to be able to restrict the search (by a
maximum warp or a heuristic) in `DTW_f`, while I can experiment with parallel
computing of the `dist_array` for `DTW_a` (on GPUs).

redpajama_set_name: RedPajamaGithub


The national representative body for veterinary professionals, the British Veterinary Association (BVA) helps members throughout their professional veterinary careers from schooling to retirement. With over 15,000 members, BVA is the only UK association to encompass all veterinary disciplines. BVA provides a voice to members and supports them through a number of services. BVA represents the views and opinions of members to the government, parliamentarians, and stakeholders throughout the UK and the EU on a variety of animal welfare, animal health and veterinary policy issues.
The BVA also develops policies based on evidence and members' expertise as well as providing legal advice and services, training, resources and professional guides to its members. The association also provides members with vast amounts of industry and professional news and information through their veterinary journals. Finally, the BVA provides workplace guidance for a variety of different topics and areas within the veterinary profession, including human resources, employment law, medicines, ethical guidance, practice management and veterinary certification.


More than 95 percent of the works are in storage.
After just a few months, he needed one with more storage.
I'd have to go all the way down to Storage.
Most of the space seemed to be used for storage.
A light was on in the back storage area, and he heard Power's voice.
The two would be out of the storage quickly enough.
As a result, no form of energy storage is needed.
I could keep them in storage, and maybe they will help my children some day.
The room is now used for storage and technology support.
You could have at least brought us out of storage.
The man on the floor had good reason to be in the storage room.
Take them down to the storage area and ask the boy what color the door is.
Do we have any legal right to the storage space?
But since 1988 it has spent much of the time in storage.
No matter how many women you take home, there's never a storage problem.
And you keep those in the No. 2 cold storage room.
He led the way back out of the storage area.
It looked like he was in some kind of storage area.
"And then the two of you went back to the storage area?"
It must be a storage room of some kind, he said.
It was used for storage in 1951 and as a school by 1985.
It is part of a small building used for storage.
It may have a small storage space and/or a head.
The last T-28 was sent to storage in early 1956.
Police believe her body had been kept in cold storage.


The recent Medicare Payment Advisory Commission ("MedPAC" or "Commission") report should serve as a shot across the bow to telehealth advocates seeking broader Medicare coverage of telehealth. In reading the telehealth chapter, it is clear to me that the MedPAC commissioners are not fully sold on telehealth because, among other reasons, they recommend that the Medicare program proceed cautiously before any expansion of the telehealth benefit. The report also makes certain conclusions that are sure to vex many in the telehealth community.
For those not familiar with MedPAC, it is an independent congressional agency that advises Congress on Medicare-related issues, and it is influential in lawmakers' consideration of Medicare issues. By way of quick background, the 21st Century Cures Act of 2016 required the Commission to provide information regarding: 1) the extent to which Medicare covers telehealth; 2) the extent to which commercial insurers cover telehealth; and 3) ways in which the telehealth coverage policies of commercial insurance plans may be incorporated into the Medicare program. This required the Commission to do a broad-reaching examination of the telehealth sector beyond Medicare.
Insurers have not found compelling evidence that telehealth reduces costs or improves patient outcomes (the use of telehealth services by commercial insurers is at less than 1 percent of plan enrollees).
Examples of services with clear evidence: telestroke is specifically referenced under this category with the Commission noting that any increase in costs to the program would be justified by the potential improvements to beneficiary access and quality. Other services specifically referenced were those that addressed beneficiaries with physically disabling and treatment-intensive conditions (e.g., ESRD, Parkinson's disease).
Examples of services with unclear evidence: direct-to-consumer, nursing home-based services, and remote patient monitoring were provided as examples of services that while expanding access to care could result in significant cost increases without clear evidence that quality of care would improve.
The report also addresses telehealth coverage by commercial plans, Medicare Advantage, and ACOs, and looks at the various telehealth-related models currently being tested by the Center for Medicare and Medicaid Innovation. The Commission ultimately recommends that Medicare take a measured approach to expanding telehealth coverage, and only considers those telehealth services that show evidence of balancing cost, access, and quality of care.
A number of significant stakeholders have not fully bought into the telehealth story, particularly on the cost and quality of care fronts. While the access argument has largely been won, the irony is that access can lead to greater utilization, which leads to greater costs under a fee-for-service system.
For purposes of coverage and reimbursement, the time to treat telehealth as a monolithic, one-size-fits-all sector may be coming to an end. The way the Commission analyzed the propriety of coverage expansion along lines of service may be a harbinger of how these issues will be analyzed in the future.
Telehealth is a woefully underutilized service with the report noting that less than one percent of commercial plan enrollees use telehealth, and telehealth coverage under Medicare accounts for an almost negligible amount of Medicare reimbursed services.
In the final analysis, the report offers a great window into how one influential stakeholder views telehealth in the context of Medicare coverage expansion, and reflects a view I have heard often in policy circles. The problem is that many analyses regarding telehealth costs and quality often fail to take into account a number of variables, not mention that issues telehealth may impact such as care coordination, disease management, and provider and patient satisfaction are not taken into consideration consistently enough. The irony is that the report comes in the midst of several positive steps recently taken by the federal government regarding virtual care such as Medicare's new approach to reimbursing remote patient monitoring and passage of the Bipartisan Budget Act (which includes several key provisions expanding coverage of telehealth). All of that notwithstanding, I would recommend that telehealth stakeholders carefully read the Commission's take on telehealth.
René focuses his practice on a range of health care and life sciences matters, with a particular focus on telehealth, digital health, and mobile health matters. He also handles matters involving Medicare and Medicaid, legislative and health policy, general compliance, and health information technology.


Cheyenne, Wyo.- At the beginning of the year, South freshman Jesse Quist won MLB's Jackie Robinson Breaking Barriers Essay Contest.
Along with a school visit from Jackie's daughter, Sharon Robinson, he won tickets to the 2018 World Series.
Quist was recognized during the pregame ceremony prior to Game 2 of the World Series between the Red Sox and Dodgers.
The sophomore also went into the Red Sox dugout and met Sox center fielder Jackie Bradley Jr.
Quist was born without arms and has had to overcome many obstacles in his life because of it. He wrote about his experience in his essay and he was chosen out of thousands of applicants.


A while back I received a lovely bundle of fabric from Stay Home Fabrics, and I used it to make a purse, glasses case, key fobs and a cup cozy. The fabric is Beyond the Backyard by Jane Farnham for Camelot Fabrics (a Canadian company).
I still had a bit left, and spring is finally here, so I decided to make another insulated lunchbag with it. I followed my own tutorial, but changed up a few things. I used a different method to box the corners, and I tried tapering the top a bit. I love how easy it is to make small changes and get different results. I also made my own straps instead of using webbing. It's a nice way to use a coordinate and gives the bag a more sophisticated look - moms pack lunches for themselves too!
You can find the tutorial by clicking here. Beyond the Backyard is such a versatile collection. It's so happy and the tossed print has bees! I love fabric with bees!
You can pick up your own Beyond the Backyard bundle at Stay Home Fabrics. While you're there, check out some of the exciting new items in store: Minky, Fusible fleece, and insulbrite (perfect for lunchbags) are all back in stock; Cloud 9 organic cotton, and Tula Pink Elizabeth are now available, as well as Babyville Boutique and precuts.
I'd love to hear if you've made a lunchbag from my tutorial yet, or if you have any questions about it.


This week's Monday Morning Art is a digital painting of a nighttime street scene from Shirlington, Virginia. It is my tribute to the work of Édouard Leon Cortès and Howard Schwartz. Both men left a deep impression on my artistic sensibilities. As always, click to enlarge.


October 29th offers a mix of data. Monday October 29ths in specific are just barely negative. October 29ths as a whole are positive on a percentage and points basis. Mondays in October are negative as are Mondays in general. 29ths overall however are positive.
Running total percent change on Monday October 29ths.
Running total percent change on October 29ths.
Running total point change on October 29ths.
Running total percent change on 29ths.
Running total percent change for October days of the week.
October 26th offers largely negative data. Friday October 26ths in specific are rather flat. October 26ths are just barely up on points but down on a percent basis. Fridays in October are positive as are Fridays in general. 26ths overall however are also positive.
Running total percent change on Friday October 26ths.
Running total percent change on October 26ths.
Running total point change on October 26ths.
Running total percent change on 26ths.
October 25th offers largely negative data. Thursday October 25ths in specific demonstrate a downtrend. October 25ths are down on points and percent basis. Thursdays in October are positive as are Thursdays in general. 25ths overall however are negative.
Running total percent change on Thursday October 25ths.
Running total percent change on October 25ths.
Running total point change on October 25ths.
Running total percent change on Thursdays.
Running total percent change on 25ths.
October 24th offers largely negative data. Wednesday October 24ths in specific demonstrate a downtrend. October 24ths are down on points and percent basis. Wednesdays in October are positive as are Wednesdays in general. 24ths overall however are negative.
Running total percent change on Wednesday October 24ths.
Running total percent change on October 24ths.
Running total point change on October 24ths.
Running total percent change on 24ths.
October 23rd largely negative data. Tuesday October 23rds in specific demonstrate a downtrend. October 23rds are down on points and percent basis. Tuesdays in October are positive as are Tuesdays in general. 23rds overall however are negative.
Running total percent change on Tuesday October 23rds.
Running total percent change on October 23rds.
Running total point change on October 23rds.


It seems reasonable to define residents' pitfalls during their attendance of a diagnostic upper gastrointestinal (GI) training course. In this regard, an assessment tool is necessary to evaluate these skills. Although various questionnaires are currently used worldwide for this purpose, a valid Persian version is lacking. The aim of this project was to develop a valid Persian questionnaire to accurately assess residents' skills while performing upper gastrointestinal endoscopy.
First, a review of the literature was performed in the databases of web of science, PubMed, CINAHL, Embase, Scopus, and Google Scholar using the following keywords: "endoscopy", "training", "resident", and "assessment". All articles and abstracts in English through 2014 were reviewed. The questionnaire was designed based on the aims of endoscopy training courses in internationally well-known GI educational centers. After the review, 24 items were recognized as important in the assessment of trainees. For the next step, 14 items were excluded due to their weak ability to evaluate the aims of the training course, based on the expert opinion of GI specialists at Tehran University of Medical Sciences, who assessed the content validity of the questionnaire. The faults of the questionnaire were revised in the pilot study. The final questionnaire contained 10 items with scores of 1-3 based on a Likert scale. The trainer filled out the questionnaire, and the result was provided to the trainee at the end of procedure. The reliability and validity of the developed questionnaire was checked by evaluating 20 internal medicine residents at the end of their training course between 2014 and 2016.
The calculated Cronbach's alpha (reliability coefficient) range was between 0.79 and 0.94 for the different domains, indicating a high level of internal consistency for the questionnaire. The measured intra-class correlation range was between 0.66 and 0.90 for the 10 items, which showed a good level of inter-rater reliability.
The results showed that the newly developed Persian-language questionnaire was appropriately accurate with regard to determining residents' skills in GI endoscopy.


text:
Aberrant dopamine transporter and functional connectivity patterns in LRRK2 and GBA mutation carriers
Amgad Droby, Moran Artzi, Hedva Lerman, R. Matthew Hutchison, Dafna Ben Bashat, Nurit Omer, Tanya Gurevich, Avi Orr-Urtreger, Batsheva Cohen, Jesse M. Cedarbaum, Einat Even Sapir, Nir Giladi, Anat Mirelman, Avner Thaler
Non-manifesting carriers (NMCs) of Parkinson's disease (PD)-related mutations such as LRRK2 and GBA are at an increased risk for developing PD. Dopamine transporter (DaT)-spectral positron emission computed tomography is widely used for capturing functional nigrostriatal dopaminergic activity. However, it does not reflect other ongoing neuronal processes; especially in the prodromal stages of the disease. Resting-state fMRI (rs-fMRI) has been proposed as a mode for assessing functional alterations associated with PD, but its relation to dopaminergic deficiency remains unclear. We aimed to study the association between presynaptic striatal dopamine uptake and functional connectivity (FC) patterns among healthy first-degree relatives of PD patients with mutations in LRRK2 and GBA genes. N = 85 healthy first-degree subjects were enrolled and genotyped. All participants underwent DaT and rs-fMRI scans, as well as a comprehensive clinical assessment battery. Between-group differences in FC within striatal regions were investigated and compared with striatal binding ratios (SBR). N = 26 GBA-NMCs, N = 25 LRRK2-NMCs, and N = 34 age-matched nonmanifesting noncarriers (NM-NCs) were included in each study group based on genetic status. While genetically-defined groups were similar across clinical measures, LRRK2-NMCs demonstrated lower SBR in the right putamen compared with NM-NCs, and higher right putamen FC compared to GBA-NMCs. In this group, higher striatal FC was associated with increased risk for PD. The observed differential SBR and FC patterns among LRRK2-NMCs and GBA-NMCs indicate that DaTscan and FC assessments might offer a more sensitive prediction of the risk for PD in the pre-clinical stages of the disease.
npj Parkinson's Disease
Dive into the research topics of 'Aberrant dopamine transporter and functional connectivity patterns in LRRK2 and GBA mutation carriers'. Together they form a unique fingerprint.
Dopamine Plasma Membrane Transport Proteins Medicine & Life Sciences 100%
Corpus Striatum Medicine & Life Sciences 78%
Parkinson Disease Medicine & Life Sciences 68%
Putamen Medicine & Life Sciences 30%
Emission-Computed Tomography Medicine & Life Sciences 20%
Prodromal Symptoms Medicine & Life Sciences 18%
Droby, A., Artzi, M., Lerman, H., Hutchison, R. M., Bashat, D. B., Omer, N., Gurevich, T., Orr-Urtreger, A., Cohen, B., Cedarbaum, J. M., Sapir, E. E., Giladi, N., Mirelman, A., & Thaler, A. (2022). Aberrant dopamine transporter and functional connectivity patterns in LRRK2 and GBA mutation carriers. npj Parkinson's Disease, 8(1), [20]. https://doi.org/10.1038/s41531-022-00285-z
Droby, Amgad ; Artzi, Moran ; Lerman, Hedva et al. / Aberrant dopamine transporter and functional connectivity patterns in LRRK2 and GBA mutation carriers. In: npj Parkinson's Disease. 2022 ; Vol. 8, No. 1.
@article{c59c7b9482594161b587e52d2a283d74,
title = "Aberrant dopamine transporter and functional connectivity patterns in LRRK2 and GBA mutation carriers",
abstract = "Non-manifesting carriers (NMCs) of Parkinson{\textquoteright}s disease (PD)-related mutations such as LRRK2 and GBA are at an increased risk for developing PD. Dopamine transporter (DaT)-spectral positron emission computed tomography is widely used for capturing functional nigrostriatal dopaminergic activity. However, it does not reflect other ongoing neuronal processes; especially in the prodromal stages of the disease. Resting-state fMRI (rs-fMRI) has been proposed as a mode for assessing functional alterations associated with PD, but its relation to dopaminergic deficiency remains unclear. We aimed to study the association between presynaptic striatal dopamine uptake and functional connectivity (FC) patterns among healthy first-degree relatives of PD patients with mutations in LRRK2 and GBA genes. N = 85 healthy first-degree subjects were enrolled and genotyped. All participants underwent DaT and rs-fMRI scans, as well as a comprehensive clinical assessment battery. Between-group differences in FC within striatal regions were investigated and compared with striatal binding ratios (SBR). N = 26 GBA-NMCs, N = 25 LRRK2-NMCs, and N = 34 age-matched nonmanifesting noncarriers (NM-NCs) were included in each study group based on genetic status. While genetically-defined groups were similar across clinical measures, LRRK2-NMCs demonstrated lower SBR in the right putamen compared with NM-NCs, and higher right putamen FC compared to GBA-NMCs. In this group, higher striatal FC was associated with increased risk for PD. The observed differential SBR and FC patterns among LRRK2-NMCs and GBA-NMCs indicate that DaTscan and FC assessments might offer a more sensitive prediction of the risk for PD in the pre-clinical stages of the disease.",
author = "Amgad Droby and Moran Artzi and Hedva Lerman and Hutchison, {R. Matthew} and Bashat, {Dafna Ben} and Nurit Omer and Tanya Gurevich and Avi Orr-Urtreger and Batsheva Cohen and Cedarbaum, {Jesse M.} and Sapir, {Einat Even} and Nir Giladi and Anat Mirelman and Avner Thaler",
note = "Funding Information: A.D., M.A., H.L., D.B.B., N.O., A.O.U., B.C., E.E.S. report no competing interests. T. Gurevich reports no competing interests relevant to this work. She received advisory board membership with honoraria to her and her institution from Abbvie Israel, Neuroderm Ltd. and Allergan. She recieves research support from Phonetica Ltd., Israeli Innovation Authority, Sagol School of Neuroscience (Brain Boost), and Parkinson{\textquoteright}s Foundation. She received travel support from Abbvie, Allergan, Medisson, and Medtronic. RM. Huchison is an employee of and owns stock in Biogen. J.M. Cedarbaum is a former employee of Biogen, and reports no competing interests relevant to this work. N. Giladi has no competing interests pertaining to this work. He serves as a member of the editorial board for the Journal of Parkinson{\textquoteright}s Disease. He serves as consultant to Sionara, Accelmed, Teva, NeuroDerm, Intec Pharma, Pharma2B, Denali and Abbvie. He received royalties from Lysosomal Therapeutics (LTI) and payment for lectures at Teva, UCB, Abbvie, Sanofi-Genzyme, Bial, and Movement Disorder Society. He received research support from the Michael J Fox Foundation, the National Parkinson Foundation, the European Union 7th Framework Program, and the Israel Science Foundation as well as from Teva NNE program, Biogen, LTI, and Pfizer. A. Mirelman reports no competing interests relevant to this work. She reports serving as advisor to Neuroderm. A. Thaler reports receiving honoraria from Abbvie- Israel. He reports no competing interests relevant to this work. Funding Information: The authors wish to thank all study participants for their devoted participation in this study. We also thank Prof. Talma Hendler and Tal Koslovski for supporting this work. This study was funded by Biogen Inc. (grant #20416). Publisher Copyright: {\textcopyright} 2022, The Author(s).",
journal = "npj Parkinson's Disease",
publisher = "Springer Nature",
Droby, A, Artzi, M, Lerman, H, Hutchison, RM, Bashat, DB, Omer, N, Gurevich, T, Orr-Urtreger, A, Cohen, B, Cedarbaum, JM, Sapir, EE, Giladi, N, Mirelman, A & Thaler, A 2022, 'Aberrant dopamine transporter and functional connectivity patterns in LRRK2 and GBA mutation carriers', npj Parkinson's Disease, vol. 8, no. 1, 20. https://doi.org/10.1038/s41531-022-00285-z
Aberrant dopamine transporter and functional connectivity patterns in LRRK2 and GBA mutation carriers. / Droby, Amgad; Artzi, Moran; Lerman, Hedva et al.
In: npj Parkinson's Disease, Vol. 8, No. 1, 20, 01.12.2022.
T1 - Aberrant dopamine transporter and functional connectivity patterns in LRRK2 and GBA mutation carriers
AU - Droby, Amgad
AU - Artzi, Moran
AU - Lerman, Hedva
AU - Hutchison, R. Matthew
AU - Bashat, Dafna Ben
AU - Omer, Nurit
AU - Gurevich, Tanya
AU - Orr-Urtreger, Avi
AU - Cohen, Batsheva
AU - Cedarbaum, Jesse M.
AU - Sapir, Einat Even
AU - Giladi, Nir
AU - Mirelman, Anat
AU - Thaler, Avner
N1 - Funding Information: A.D., M.A., H.L., D.B.B., N.O., A.O.U., B.C., E.E.S. report no competing interests. T. Gurevich reports no competing interests relevant to this work. She received advisory board membership with honoraria to her and her institution from Abbvie Israel, Neuroderm Ltd. and Allergan. She recieves research support from Phonetica Ltd., Israeli Innovation Authority, Sagol School of Neuroscience (Brain Boost), and Parkinson's Foundation. She received travel support from Abbvie, Allergan, Medisson, and Medtronic. RM. Huchison is an employee of and owns stock in Biogen. J.M. Cedarbaum is a former employee of Biogen, and reports no competing interests relevant to this work. N. Giladi has no competing interests pertaining to this work. He serves as a member of the editorial board for the Journal of Parkinson's Disease. He serves as consultant to Sionara, Accelmed, Teva, NeuroDerm, Intec Pharma, Pharma2B, Denali and Abbvie. He received royalties from Lysosomal Therapeutics (LTI) and payment for lectures at Teva, UCB, Abbvie, Sanofi-Genzyme, Bial, and Movement Disorder Society. He received research support from the Michael J Fox Foundation, the National Parkinson Foundation, the European Union 7th Framework Program, and the Israel Science Foundation as well as from Teva NNE program, Biogen, LTI, and Pfizer. A. Mirelman reports no competing interests relevant to this work. She reports serving as advisor to Neuroderm. A. Thaler reports receiving honoraria from Abbvie- Israel. He reports no competing interests relevant to this work. Funding Information: The authors wish to thank all study participants for their devoted participation in this study. We also thank Prof. Talma Hendler and Tal Koslovski for supporting this work. This study was funded by Biogen Inc. (grant #20416). Publisher Copyright: © 2022, The Author(s).
N2 - Non-manifesting carriers (NMCs) of Parkinson's disease (PD)-related mutations such as LRRK2 and GBA are at an increased risk for developing PD. Dopamine transporter (DaT)-spectral positron emission computed tomography is widely used for capturing functional nigrostriatal dopaminergic activity. However, it does not reflect other ongoing neuronal processes; especially in the prodromal stages of the disease. Resting-state fMRI (rs-fMRI) has been proposed as a mode for assessing functional alterations associated with PD, but its relation to dopaminergic deficiency remains unclear. We aimed to study the association between presynaptic striatal dopamine uptake and functional connectivity (FC) patterns among healthy first-degree relatives of PD patients with mutations in LRRK2 and GBA genes. N = 85 healthy first-degree subjects were enrolled and genotyped. All participants underwent DaT and rs-fMRI scans, as well as a comprehensive clinical assessment battery. Between-group differences in FC within striatal regions were investigated and compared with striatal binding ratios (SBR). N = 26 GBA-NMCs, N = 25 LRRK2-NMCs, and N = 34 age-matched nonmanifesting noncarriers (NM-NCs) were included in each study group based on genetic status. While genetically-defined groups were similar across clinical measures, LRRK2-NMCs demonstrated lower SBR in the right putamen compared with NM-NCs, and higher right putamen FC compared to GBA-NMCs. In this group, higher striatal FC was associated with increased risk for PD. The observed differential SBR and FC patterns among LRRK2-NMCs and GBA-NMCs indicate that DaTscan and FC assessments might offer a more sensitive prediction of the risk for PD in the pre-clinical stages of the disease.
AB - Non-manifesting carriers (NMCs) of Parkinson's disease (PD)-related mutations such as LRRK2 and GBA are at an increased risk for developing PD. Dopamine transporter (DaT)-spectral positron emission computed tomography is widely used for capturing functional nigrostriatal dopaminergic activity. However, it does not reflect other ongoing neuronal processes; especially in the prodromal stages of the disease. Resting-state fMRI (rs-fMRI) has been proposed as a mode for assessing functional alterations associated with PD, but its relation to dopaminergic deficiency remains unclear. We aimed to study the association between presynaptic striatal dopamine uptake and functional connectivity (FC) patterns among healthy first-degree relatives of PD patients with mutations in LRRK2 and GBA genes. N = 85 healthy first-degree subjects were enrolled and genotyped. All participants underwent DaT and rs-fMRI scans, as well as a comprehensive clinical assessment battery. Between-group differences in FC within striatal regions were investigated and compared with striatal binding ratios (SBR). N = 26 GBA-NMCs, N = 25 LRRK2-NMCs, and N = 34 age-matched nonmanifesting noncarriers (NM-NCs) were included in each study group based on genetic status. While genetically-defined groups were similar across clinical measures, LRRK2-NMCs demonstrated lower SBR in the right putamen compared with NM-NCs, and higher right putamen FC compared to GBA-NMCs. In this group, higher striatal FC was associated with increased risk for PD. The observed differential SBR and FC patterns among LRRK2-NMCs and GBA-NMCs indicate that DaTscan and FC assessments might offer a more sensitive prediction of the risk for PD in the pre-clinical stages of the disease.
JO - npj Parkinson's Disease
JF - npj Parkinson's Disease
Droby A, Artzi M, Lerman H, Hutchison RM, Bashat DB, Omer N et al. Aberrant dopamine transporter and functional connectivity patterns in LRRK2 and GBA mutation carriers. npj Parkinson's Disease. 2022 Dec 1;8(1):20. doi: 10.1038/s41531-022-00285-z

redpajama_set_name: RedPajamaCommonCrawl


As cell tower lease buyouts become more prevalent, Lessees (Tower Companies and Wireless Carriers) are adding Right of First Refusal (ROFR) clauses to their cellular leases. A right of first refusal clause gives the Lessee the right to match any offer that a Third Party Lease Buyout Company would make to purchase the lease from the Lessor (Landowner/ Property Owner).
On the surface level, a cell tower lease ROFR clause doesn't seem like a bad idea. A landowner might assume that the worst case would be that it just changes who purchases the lease, but doesn't limit the price being paid for the lease since the buyer is simply matching the previous offer. The problem with this line of thinking is that when leases have ROFR clauses, Lessees are less likely to purchase the lease at a competitive price. Rather, they simply wait to match the bids of any other companies. Since most landowners really don't know the value of their lease, that often means that ROFR clauses result in the landowner leaving a significant amount of money on the table.
"In recent years, tower companies and wireless carriers have been aggressively pushing to include ROFR clauses in all wireless lease agreements. Why? Because they'd rather own the rights to your lease then be tied to negotiations with a lease buyout company."
To further complicate matters, ROFR clauses are often drafted with strategic language meant to protect the Lessee. For instance, one might state that the Lessee can purchase the lease on a pro-rata basis. That means that if a lease buyout company offered to purchase a given cellular lease but wanted more ground space than was currently being used (to account for the possibility of additional future tenants), the Lessee would only have to purchase the original portion of the lease and pay a pro-rata share of the comparable offer. For example, suppose you are a landowner who is leasing 300 square feet of ground space. You receive an offer from a lease buyout company to purchase your lease for $100,000, but this offer includes the addition of another 300 square feet, making the total ground space 600 square feet. The Lessee could elect to purchase only the original 300 square feet for $50,000, and you (the landowner) would have to accept this.
In recent years, Tower Companies and Wireless Carriers have been aggressively pushing to include ROFR clauses in all cellular lease agreements. This is because there has been a rise in the number of Lease Buyout Companies, such as Unison, WCP, APWIP, Tristar, and Landmark Dividend. Tower owners don't want Leaseholders to sell to Buyout Companies for two reason: 1. Tower owners fear that Leaseholders won't be as diligent in meeting obligations under the original contract when they are no longer receiving monthly payments; and 2: Tower owners fear that negotiations with Buyout Companies will be more expensive than with the original Leaseholder.
Lately, some Tower Companies have been sending letters to landowners asking them to add ROFR clauses to existing leases for a one-time payment of $2,000. We suspect that some landowners will see this as a good way to get some extra cash and agree to add the Right of First Refusal clause to their lease. In our opinion, this is a poor decision – and one that may come back to haunt the landowner in the future. We recommend against signing a document that adds a Right of First Refusal to your existing lease agreement. As it pertains to a new cell tower lease agreement, you may not have a choice. If that is the case, at least make sure to have your attorney review the language prior to signing to confirm that it is narrowly drafted. If you need legal assistance, please visit our partner Cell Tower Attorney.
We can help you if there is an right of first refusal in your lease. We can assess your situation and teach you how to respond to the offer(s) in order to get the best price for your lease. If you have a buyout offer for your lease, please call us and we will help you to level the playing field before finalizing any agreements.


Authorities said Tuesday that they found the body of a man who fell from a boat in Boston Harbor late Saturday night.
A Coast Guard searches the waters off of Castle Island on July 28, 2013 for a man who fell from a ferry the night before.
Nearly two days after the search for a man who fell from a ferry in Boston Harbor was called off, his body was recovered by police Tuesday afternoon.
The body of the 41-year-old Wilmington man was found in the water between Castle and Spectacle islands about 1:15 p.m. by Boston and Quincy police, according to the Suffolk district attorney's office. Police were using sonar equipment when they found the body.
The man's remains were taken to the Boston police marine unit where they were transferred to state police who are investigating the death.
Because the death does not appear to be suspicious, the man's name was not released.
Authorities received word about 10:45 p.m. Saturday of a man overboard from the Provincetown II, according to a statement from the Coast Guard. The ferry crew notified the Coast Guard that the man had fallen into the water near Castle Island. The man was on the third deck at the time he fell.
The ferry was hosting a country-music themed cruise and the man was trying to climb the boat's railings when he fell, according to the Globe.
An autopsy was expected to determine the cause and manner of death, the district attorney's office said.


text:
Social wage
Malthusianism is alive and well as feminists celebrate declining birth rate
Since they cannot admit to a solution lying outside of capitalist production relations, 'women's rights' advocates are reduced to prettifying their chains.
Friday 2 September 2022
The liberation of women is not primarily a question of male prejudice or glass ceilings, but of the practical ways in which women are enabled to take their place in social and productive life. Women's rights in the USSR and other socialist countries were assured by socialising much of the socially-necessary work they had formerly carried out in private – care of the young, the disabled and the elderly, cooking, laundry etc. That is why poll after poll of citizens in former Soviet countries reveal a strong nostalgia for a system that took care of all working people and valued them. Not coincidentally, this also led to far better outcomes in terms of social cohesion, children's development and educational achievement.
In recent years, much has been made of declining birth rates around the world, particularly in western countries. Whilst occasionally some fears are expressed about how this may impact social care for pensioners, the most common reaction tends to be a dismissive: "So what? The planet has too many people anyway."
Such Malthusian sentiment is almost a public prejudice amongst the population today, much like the fear of being 'overcrowded' by immigration. A recent article by one Martha Gill in the I newspaper carried the provocative title 'Declining birth rates are a cause for celebration' provided an insight into the 'logic' of modern liberal anti-natalist thought.
Gill claimed that the advance of what she calls "women's rights" has made declining birth rates inevitable. Defining 'women's rights' simply as women entering the workforce and having access to abortion on demand, Gill claims that the only way to deal with falling birth rates and simultaneously protect 'women's rights' is to import immigrants from countries which lack such 'rights'.
In her words, the supply of immigrants will not run out "until the patriarchy is smashed worldwide" – ie, until the adoption of her so-called 'women's rights' everywhere causes a global shortage of working-age people.
She fails to see that the 'right' to choose abortion is no right at all. The vast majority of people who 'choose' abortion do so because they feel they have no choice: the advent of a child, or another child, would impact negatively on their ability to earn a living, condemning not just the mother but her whole family to such a lowered standard of living that they would find it intolerable.
Not many people would 'choose' to be a single mother living on benefits, either for themselves or for their children. Interestingly, it is rare indeed for anti-abortionists to advocate the provision of abundant social facilities such as affordable nurseries and after-school facilities that would make a real difference to whether or not a woman felt she had to 'choose' abortion.
Just like all capitalistic ideologies that sanctify personal short-term profit over the long-term collective interests of humanity, liberal feminism and its individualist conception of 'women's rights' is no different. Abortion is viewed by the bourgeoisie as a cheap alternative to providing decent social facilities that enable child-rearing to be combined comfortably with working in social production.
The aim of liberal feminism is to tell women how lucky they are to have the 'choice' of having an abortion!
The fact of the matter is that as long as capitalist relations of production remain, women face a binary choice between career or children. When private profit is the main motivator of production, hiring mothers will always be unattractive to employers because they work fewer hours (since no government will fund high-quality childcare at affordable prices).
Essentially, the lack of good-quality, freely-available and affordable childcare comes down to the fact that paying for it means reducing profitability. Either employers would have to pay more tax, or they would have to pay higher wages so that workers could be taxed more. Either way, profits would go down.
The only societies to have fully escaped from this 'Sophie's choice' situation are those that transitioned to a socialist economy in which profitability is no longer the criterion for production. Rather, all production is planned for the benefit of society as a whole.
As anyone who wants to get ahead as a mainstream media columnist is, of course, ideologically forbidden from acknowledging the successes of the socialist countries in this or any other field, the only options left are either to wind the clock back to Victorian-style domestic slavery or to go full Malthusian and try to prettify the gradual decline of populations.
Given the current overproduction crisis and capitalism's tendency to seek to destroy the excess productive forces to extricate itself – and remembering that humans themselves are also productive forces – it is likely that the glorification of childlessness by the lackeys of imperialism will only grow louder.
Meanwhile it is left to socialist societies to put children back where they belong – at the very heart of society, as both our greatest treasure and our hope for the future.
Prol 110: October 2022
Iran and the western-manufactured hijab protests
Cynical calculations behind America illegalising abortion
Hungry schoolchildren; another sign of a failed system
Food bank Britain
Deborah Lavin: Early feminism, bourgeois and proletarian
The women's movement in Britain
Comrade Lauren: 'Identity politics divide workers'
October 100: Women's liberation
Attempts to cast imperialist countries as champtions of women's rights are laughable to anyone familiar with the declining position of women in the west.
Has the Roe v Wade abortion rights ruling been overturned in the hopes of shoring up Joe Biden's electoral prospects?
12 Jul 2022, Lalkar
When an economic system can't provide basics like food and warm shelter to its people, it is time for it to be replaced.
22 Oct 2022, Proletarian
British families are relying on charity to eat as the market and the government both fail to provide even such a basic necessity as food.
What did the early Marxists think about birth control and women's rights? How did their views differ from those of the liberal feminists?
4 Apr 2020,
Why is the women's movement in this country so totally unappealing to working-class women? Why do Marxists oppose 'feminism'?
16 Mar 2019,
Women's liberation is a question for all of us; a key part of the working-class struggle for socialism.
8 Mar 2021,
16 Mar 2019, Proletarian TV
The October Revolution changed forever the perception and accepted role of women in society, showing the way to complete emancipation and equality.
5 Oct 2018, Proletarian TV


Find out what UCCF has been doing over the year.
The Annual Review gives you an exciting summary of what we've been doing, including inspiring stories of people coming to faith in Christ.
You can also read a breakdown of our finances and find out more about some of our behind-the-scenes work.
Please send me a copy of your latest Annual Report.
Please send me your Annual Report each year.
While you're here, would you also like to sign up for Impact and Focus, our termly magazine and prayer diary?
Yes, please send me Impact and Focus.


text:
Category: Games/Play
Design · Digital Media · Games/Play · Human-ities · Technology
The 21st Century Will Be Defined By Games, a Manifesto.
September 10, 2013 September 10, 2013 Sebastian AlvarezLeave a comment
Previous centuries have been defined by novels and cinema. In a bold manifesto we're proud to debut here on Kotaku, game designer Eric Zimmerman states that this century will be defined by games.ore
Below is Zimmerman's manifesto, which will also appear in the upcoming book The Gameful World from MIT press. We invite you to read it, to think about it and even to annotate it. Zimmerman's manifesto is followed by an exploration of the ideas behind it, in an essay by author and professor Heather Chaplin. In the days to come, we'll be expanding the discussion even further with perspectives from other gamers and game-thinkers. But let's start with the big ideas. Let's start with a manifesto by gamers, about games, for the world we live in…
Games are ancient.
Digital technology has given games a new relevance.
The 20th Century was the century of information.
In our Ludic Century, information has been put at play.
In the 20th Century, the moving image was the dominant cultural form.
The Ludic Century is an era of games.
We live in a world of systems.
There is a need to be playful.
We should think like designers.
Games are a literacy.
Gaming literacy can address our problems.
In the Ludic Century, everyone will be a game designer.
Games are beautiful. They do not need to be justified.
Expand on each of these claims HERE
Film/Video/New Media · Games/Play · Social/Politics
NFB International Women's Day: A curated selection of films about women
March 8, 2013 March 8, 2013 Sebastian AlvarezLeave a comment
In celebration of International Women's Day, the National Film Board of Canada (NFB) is streaming the full Karen Cho's award-winning NFB feature documentary Status Quo? The Unfinished Business of Feminism in Canada, and many others until Sunday, 10 March. Click HERE to see them.
Architectonic · Education · Games/Play · Human-ities · Public Space
Architektur für Kinder
December 30, 2012 December 30, 2012 Sebastian Alvarez1 Comment
Architektur für Kinder is an ongoing research project about the history of playgrounds and will transform into an international show in the Carnegie Museum of Art in Pittsburgh PA (June 2013).
Art/Aesthetics · Digital Media · Film/Video/New Media · Games/Play · Performativity · Technology · Videos
Hollywood Joystick and Google Earth Movies
November 25, 2012 November 25, 2012 Sebastian AlvarezLeave a comment
Somewhere between film and video-game, in the interactive installation Hold On, you can go your way through famous movie's sequences like those from The Shining, Way of the Dragon or Jurassic Park.
Thanks to an arcade-type device, you can choose and control sequences from those video-ludic style movies. Paradoxically using both the very contemporary interactivity process and the old recording practice, the spectator can control the movements of the main actor turned into an avatar. The spectator can break the logical rhythm of the movie and lengthens the action using his joystick. He can delay the inescapable course of the sequence unit its end, both playing with and against time.
When machinimas are currently exploring video games to reproduce cinematics, Hold On, on the contrary, develops a playful and dynamic experience based on cinema.
Google Earth Movies project consists in a series of interactive adaptations of emblematic sequences extracted from famous movies, recreated and played in Google Earth. In this visualization software, which allows exploring the 3D world from many satellite sources – topographical and weather satellites – the original video camera movements are precisely transcribed in the original filming location and with the original soundtrack synchronized. Moreover, the software being interactive, a joystick may be used to manipulate the camera during the reading to observe the whole screen out landscape. Thus, it is a striking cinematographic experience that is given to us: the "objectivation" operated by Google Earth, presenting ghostly worlds emptied from any characters, allows to be focused on the framing and the editing of these well-known movies haunting our imagination. Putting these narrative sequences back in context establishes a true bridge between these cinematographic, physical and virtual spaces. The spectator is freed from the frame and from the territory; he is given a new space of time, a sort of intimate screen out, interrogating its link to the real and to fiction.
All the works above by Émilie Brout & Maxime Marion. Text and Images taken from their website.
Bio · Design · Games/Play · Projects · Public Space · Vital-Edible-Health
The Universal Tea Machine
August 30, 2012 August 30, 2012 Sebastian AlvarezLeave a comment
"Universal Tea Machine" is a gargantuan cross between a tea-making device, a primitive computer and a pinball machine. As tall as a giraffe, as long as a double-decker bus and as colourful as a fun fair, the UTM is a playful new way to engage with London's rich and vibrant history.
The UTM is a computer that relies on teamwork and calculation to produce the perfect cup of tea. By pulling a sequence of handles, you release a series of balls from their caddies at the top of the UTM. Through a simple set of commands, engaging the binary calculation of an adding machine, you then instruct the making of your ideal cuppa.
Silly and serious, interactive and spectacular, modern and historic, calculating and fantastical, the UTM encourages kids of all ages – from 1 to 100 – to engage with London's dynamic history of trade, calculation and tea-drinking.
Text and Images via The Bartlett School of Architecture
Bio · Design · Digital Media · Education · Games/Play · Science · Technology
Played By Humans, Scored By Nature. EteRNA, an online game, helps build a new RNA warehouse
According to EteRNA: By playing EteRNA, you will participate in creating the first large-scale library of synthetic RNA designs. Your efforts will help reveal new principles for designing RNA-based switches and nanomachines — new systems for seeking and eventually controlling living cells and disease-causing viruses. By interacting with thousands of players and learning from real experimental feedback, you will be pioneering a completely new way to do science. Join the global laboratory!
EteRNA is starting with simple shapes like "the finger" and "the cross" to make sure you can nail the fundamentals. And then we'll be moving on to elaborate shapes like trees. And then molecules that switch folds when they sense a specific other piece of RNA. This might take a few weeks, or it might take a year — we want to make sure we can ace these exercises.
After that, we will embark on one of a few epic projects – perhaps we'll make the first RNA random-access memory for a computer. Or switches that enables cells to fluoresce if they start expressing cancer genes. Or how about a nanomotor? Or a nanoLED display? There are lots of options, and we'll let you propose your own and choose.
Finally, you'll start seeing a few other kinds of puzzles popping up in later stages: The ability to play with RNAs in three dimensions. The ability to see natural RNAs from bacteria, viruses, and humans; and challenges to predict their properties. Stay tuned.
Play EteRNA
Digital Media · Games/Play · Sonic/Musical
Zineth
Developed by The Arcane Kids as a student project, this Free game combines a colorful low polygon world with game elements of Tony Hawks Skateboarding and Prince Of Persia. Download HERE
Art/Aesthetics · Book-Text-Read-Zines · Games/Play · Philosophy · Social/Politics · Theory
On Benjamin's Public (Oeuvre)
July 30, 2012 Sebastian AlvarezLeave a comment
On the run from the Nazis in 1940, the philosopher, literary critic and essayist Walter Benjamin committed suicide in the Spanish border town of Portbou. In 2011, over 70 years later, his writings enter the public domain in many countries around the world. Anca Pusca, author of Walter Benjamin: The Aesthetics of Change, reflects on the relevance of Benjamin's oeuvre in a digital age, and the implications of his work becoming freely available online.
Via The Public Domain Review. Continue HERE
Design · Games/Play · Sculpt/Install
Fabric (soccer) Balls
Fabric Balls by Klas Herbert
Earthly/Geo/Astro · Eco/Adaptable · Festivals · Games/Play · Performativity
Night hikes/runs. NVA's Speed of Light
July 9, 2012 Sebastian AlvarezLeave a comment
Through a mass choreographed act of walking and endurance running, NVA's Speed of Light will illuminate the iconic mountain, which rises dramatically from the heart of the city. A mesmerizing visual display unfolds on the ascent to the summit as hundreds of runners wearing specially commissioned light suits take to the intricate path networks below. As a member of the walking audience, you become part of the work, with portable light sources set against the dark features of the mountainside.
Text and Image via Edinburgh International Festival.
Games/Play · Performativity · Sculpt/Install · Videos
Mouth Factory
June 28, 2012 June 28, 2012 Sebastian AlvarezLeave a comment
Chewing drill
"Mouth Factory", by Cheng Guo, is a series of functional machines specifically designed to be operated by the mouth of the user. It explores the capabilities and versatility of this wondrous organ and correlating facial expressions, re-contextualized within the realm of production. As a comment on human enhancement, the project aims to explore the aesthetic of production through a series of performative devices. By focusing on the mouth, the production devices acquire a fantastic quality that amplifies and render visible the reciprocal relationship and effects between our body and our tools.
Inhaling vacuum form machine
Blowing rotational molding machine
Design · Digital Media · Games/Play · Social/Politics · Technology
Molleindustria: the persuasive potentials of subverting mainstream video gaming
May 15, 2012 Sebastian AlvarezLeave a comment
Molleindustria aims to reappropriate video games as a popular form of mass communication. Our objective is to investigate the persuasive potentials of the medium by subverting mainstream video gaming clichè (and possibly have fun in the process).
According to founder Paolo Pedercini:
We can no longer consider videogaming as a marginal element of our everyday lives. In recent years, the turnover of the videogame industry has exceeded that of cinema, and there are a growing number of adult and female players. There are more frequent overlaps with other media: there are videogames for advertisements (advergames), for educational purposes and for electoral propaganda. space invadersHow did videogames become such a central element of the mediascape? During the second half of the nineties, major entertainment corporations extended their activities in this sector and extinguished or absorbed small producers.
Now videogames are an integral part of the global cultural industry, and they are in a strategic position in the ongoing processes of media convergence. These developments inhibit the political and artistic emancipation of this medium: every code line is written for the profit of a big corporation.
All text via Molleindustria
Film/Video/New Media · Games/Play · Performativity
The Politics of Competitive Board Gaming Amongst Friends
May 8, 2012 May 9, 2012 Sebastian Alvarez1 Comment
Jay Cheel: "Here's a new short that I filmed with some friends over the past month. It's a 10 minute documentary called "The Politics of Competitive Board Gaming Amongst Friends"; a title that pretty much sums up the content.
From a technical standpoint, I wanted to shoot this short as a sort of dry run for the recreations in my upcoming feature documentary, How to Build a Time Machine. Although the content and approach will be pretty different than what's presented here, I just wanted to take on a small project that would allow me to play around with re-enactments. I shot this with the Panasonic AF100, using the following lenses: Nikon 50mm, Nikon 35mm, Panasonic Lumix 14mm. I didn't do a whole lot for lighting aside from assisting some of the practical lights in Matt's apartment (a 650 bounced off the ceiling), and stringing some coloured Christmas lights in the background for some visual points of interest. For the interviews, it was simply a single bulb cool light hung directly overhead the subjects."
Digital Media · Games/Play · Performativity · Technology · Videos
Photo/Nykto
April 26, 2012 April 26, 2012 Sebastian AlvarezLeave a comment
Photo/Nykto is an experimental game conceived by Annelore Schneider and Douglas Edric Stanley as part of the « Unterplay » project at the Master Media Design —HEAD, Genève. It is a game for nyktophobes and photophobes. It is played by switching on and off the lights in order to avoid reaching the edge of the screen. The score increases exponentially near the edges, and speeds up with each change from light to dark and back.
Design · Education · Games/Play · Performativity · Projects · Science · Sculpt/Install · Videos
Meet Arvind Gupta and his Toys from "Trash"
Arvind Gupta is an Indian toy inventor that popularizes science. His series of films by Arvind Gupta Toys is absolutely wonderful.
FILMS and PHOTOS
Books on Education from Arvind Gupta
Angry Birds, Farmville and Other Hyperaddictive 'Stupid Games'
April 6, 2012 April 5, 2012 Sebastian AlvarezLeave a comment
In 1989, as communism was beginning to crumble across Eastern Europe, just a few months before protesters started pecking away at the Berlin Wall, the Japanese game-making giant Nintendo reached across the world to unleash upon America its own version of freedom. The new product was the Game Boy — a hand-held, battery-powered plastic slab that promised to set gamers loose, after all those decades of sweaty bondage, from the tyranny of rec rooms and pizza parlors and arcades.
And so a tradition was born: a tradition I am going to call (half descriptively, half out of revenge for all the hours I've lost to them) "stupid games." In the nearly 30 years since Tetris's invention — and especially over the last five, with the rise of smartphones — Tetris and its offspring (Angry Birds, Bejeweled, Fruit Ninja, etc.) have colonized our pockets and our brains and shifted the entire economic model of the video-game industry. Today we are living, for better and worse, in a world of stupid games.
Game-studies scholars (there are such things) like to point out that games tend to reflect the societies in which they are created and played. Monopoly, for instance, makes perfect sense as a product of the 1930s — it allowed anyone, in the middle of the Depression, to play at being a tycoon. Risk, released in the 1950s, is a stunningly literal expression of cold-war realpolitik. Twister is the translation, onto a game board, of the mid-1960s sexual revolution. One critic called it "sex in a box."
Continue article by SAM ANDERSON at NYT HERE
Design · Digital Media · Film/Video/New Media · Games/Play · Performativity · Technology
8-bit Google Maps
March 31, 2012 Sebastian AlvarezLeave a comment
Google Maps is now available for 8-bit Nintendo Entertainment Systems (NES). Availability in Google Store is TBD but you can try it on your browser by going to http://maps.google.com and clicking "Quest" in the upper right hand corner of the map.
Design · Games/Play · Human-ities · Performativity · Sculpt/Install
Museum of Talking Boards
"Ouija knows all the answers. Weird and mysterious. Surpasses, in its unique results, mind reading, clairvoyance and second sight. It furnishes never failing amusement and recreation for the entire family. As unexplainable as Hindu magic—more intense and absorbingly interesting than a mystery story. Ouija gives you entertainment you have never experienced. It draws the two people using it into close companionship and weaves about them a feeling of mysterious isolation. Unquestionably the most fascinating entertainment for modern people and modern life."
With these words, William Fuld (businessman, designer, toy maker, with no branch factories or offices) invites you, the American people, to enter the strange, twilight world of Ouija, the Wonderful Talking Board.
Visit the gallery of the Museum of Talking Boards
Games/Play · Performativity · Sculpt/Install · Sonic/Musical
The Vinyl Rally
Devised and Constructed by Lucas Abela, The Vinyl Rally is an immersive participatory play-set playing off vinyl fetishism, video arcade mystique and the machismo of motor sports in a video game played within a real world setting.
Classic first person video racing is simulated as remote control cars with styli attached, race across a track constructed from a mass of disused vinyl records. Transmitting sound (produced as the styli skim along the vinyl surface) and vision (from wireless spy cameras mounted to the front of each car) to re-engineered old school racing consoles with immersive 50" flat screens. Here players navigate the course from the vehicles point of view, not only controlling the cars movements, but also the parameters of the resulting sounds they create via a series of unique audio effects mounted onto the dashboard (by Last Gasp Laboratories) giving each car its own distinct aural flavor. These sounds are emitted from speakers built into the seats causing them to vibrate in correspondence with the movements on screen, producing a personally immersive experience aurally, visually and physically that can only be truly appreciated seated at the controls.
Text and Images via Dualplover
Design · Digital Media · Games/Play · Motion Graphics · Science
February 14, 2012 Sebastian AlvarezLeave a comment
The Scale of the Universe is a visualization created by Cary Huang. This interactive scale of the universe shows the relative sizes of "everything" from the micro to the macro.
http://htwins.net/
Games/Play · Human-ities · Performativity · Social/Politics · Vital-Edible-Health
How professional football might end due to the increasing visibility of head injuries
The NFL is done for the year, but it is not pure fantasy to suggest that it may be done for good in the not-too-distant future. How might such a doomsday scenario play out and what would be the economic and social consequences?
By now we're all familiar with the growing phenomenon of head injuries and cognitive problems among football players, even at the high school level. In 2009, Malcolm Gladwell asked whether football might someday come to an end, a concern seconded recently by Jonah Lehrer.
Before you say that football is far too big to ever disappear, consider the history: If you look at the stocks in the Fortune 500 from 1983, for example, 40 percent of those companies no longer exist. The original version of Napster no longer exists, largely because of lawsuits. No matter how well a business matches economic conditions at one point in time, it's not a lock to be a leader in the future, and that is true for the NFL too. Sports are not immune to these pressures. In the first half of the 20th century, the three big sports were baseball, boxing, and horse racing, and today only one of those is still a marquee attraction.
Written by Tyler Cowen and Kevin Grier, GRANTLAND. Continue HERE
Soccer's concussion problem
Games/Play · Performativity · Videos
The World's Largest Dodgeball Game
From University of Alberta — The University of Alberta's ownership of the Guinness dodgeball record has been much like a yoyo game—now you have it, now you don't. And so on Feb. 3, U of A students, staff and faculty were back at it for a third attempt to reclaim the Guinness World Record for the largest number of players in a game.
After more than an hour-long of pushing, running and throwing by players, the Guinness World Record adjudicator, Philip Robertson, who flew in from New York for the game, took to the stage.
"What can I say," he says. "I've never seen so many people throw dodge balls against each other before. It was tremendous to watch, really good fun. The guidelines were all followed. And with that, I'm happy to announce that University of Alberta, Canada, has a new Guinness World Record."
Via msnbc
Architectonic · Games/Play · Human-ities · Performativity
A new Lego line for girls is offensive, critics say.
Lego toys have always seemed pleasantly gender-neutral. Perhaps that's why the new Lego Friends line for girls has triggered a fair bit of protest from some health and equal-rights organizations.
The new line, whose characters sport slim figures and stylish clothes, will contribute to gender stereotyping that promotes body dissatisfaction in girls, said Carolyn Costin, an eating disorders specialist and founder of the Monte Nido Treatment Center in Malibu.
Online petitions have been started to protest the line, which includes a Butterfly Beauty Shop and a Your Fashion Designer Workshop. The International Assn. of Eating Disorder Professionals said the toys were "devoid of imagination and promote overt forms of sexism."
Written by Shari Roan, Los Angeles Times. Continue HERE
LEGO Group commentary on attracting more girls to construction play
Digital Media · Earthly/Geo/Astro · Games/Play · Sonic/Musical · Technology
OTERP: A Prototype for a Musical Geolocative Game
January 24, 2012 January 23, 2012 Sebastian AlvarezLeave a comment
Oterp is a mobile phone game project using a GPS sensor to manipulate music in real time, depending on the player's position on Earth. It generates new melodies when traveling. The objective of Oterp is to mix the reality of our everyday environment with a video game. This is a new way to imagine our movements in a society increasingly on the move and dependent on mobile interfaces.
Design · Digital Media · Games/Play · Performativity · Technology
Cubelets! Cubelets! Cubelets!
January 8, 2012 Sebastian AlvarezLeave a comment
Cubelets are magnetic blocks that can be snapped together to make an endless variety of robots with no programming and no wires. You can build robots that drive around on a tabletop, respond to light, sound, and temperature, and have surprisingly lifelike behavior. But instead of programming that behavior, you snap the cubelets together and watch the behavior emerge like with a flock of birds or a swarm of bees.
Each cubelet in the kit has different equipment on board and a different default behavior. There are Sense Blocks that act like our eyes and ears, Action blocks, and Think blocks. Just like with people, the senses are the inputs to the system.
Get your Cubelets HERE
Design · Games/Play · Performativity · Videos
Massage your Mind (abstractly and geometrically) with Zen Magnets
January 5, 2012 January 5, 2012 Sebastian AlvarezLeave a comment
Recommendation: Mute the video above and play the track below.
http://ia600402.us.archive.org/6/items/tube104/tube104-03-cory_allen_-_satori_in_atlantis.mp3Satory in Atlantis by Cory Allen. Released on Test Tube
Zen Magnets are small but curiously strong rare earth super-magnets, 5mm in diameter. How powerful? 8 Times more powerful than the ceramic magnets driving your speakers. 30 Times more powerful than the average fridge magnet.
Pull them into a chain, fold them into a fabric, and meld them into limitless shapes: both abstract and geometric, flat or 3D. Use them when you need to massage your mind, practice your patience, relieve some boredom or alleviate some stress.
Head feeling a bit dull? Maybe your brain just needs to get up and stretch a bit. You know, give it some exercise, get the blood flowing; make that gray matter in your skull stronger, faster. If allowed, Zen magnets can be a great workout for both hemispheres of your brain: The left brain – directing the right hand – that is responsible for logic, math and language. The right brain – controlling the left hand – that is responsible for spatial abilities, creativity and visualization. With total creative control, Zen magnets are more than the average puzzle advent, they are an enjoyable means to actual mental development.
Kinetic toys from Marta Bakowski
Marta Bakowski: This self-initiated project comes from a primary research on "Emotional Design" or the emotional relationships we hold with objects. My main focus was on the power of movement and how it can affect our mood or perception of things when applied to an object.
Employing inherently playful materials such as springs, feathers, motors and gears, I created a series of small abstract, often geometrical constructions that I animated with a distinct rhythm and endearing characteristics, almost bringing each 'creature' to life.
This series of experiments resulted in a collection of colorful mechanical wooden toys, desirable to children and adults alike, which prove that fantasy is not necessarily a "stage one grows out of".
This video is part of a research about movement. In this three dimensional brainstorming, each object is animated with a distinct rhythm and endearing characteristics which provide each 'creature' with a different personality.
Blog-Sites · Digital Media · Games/Play · Performativity
Get your Pixelated Fireplace for Those Cold Nights
Fireplace by Ted Martens is an interactive pixelated fireplace for Mac or PC. Type marshmallow, hotdog, eat, water, photo, or fireworks to enhance the interactive fireplace experience. The digital log burns down to ash in about 30 minutes.


There are two distinct elements to our services: investment management to meet your charity's individual requirements, and support for your trustees and management team, as well as the charitable sector as a whole.
We build our service around your charity's priorities. Our approach means you do not have to compromise on what you want from your investment manager. The diversity of the charities we work with shows our ability to meet individual requirements.
Your investment manager takes the time to understand your charity, the long-term strategy you want your portfolio to support and how you want us to work with your trustees and management team. We create an individual strategy to match your charity's income and growth targets, attitude to risk and investment policy.
Rathbones is part of an independently owned company, so we can look across the whole of the market to find the best options for your charity's goals. Not all firms give their managers such flexibility: we do and it is an important advantage. It means your investment manager has more opportunity to apply his or her expertise. Our investment managers are supported by our central investment process and guidance from our in-house investment committees.
Many of the charities we work with have long histories. We feel a responsibility to make sure you can continue to support those who depend on you. To help your charity have a successful future, we aim to achieve consistent returns for you over the long term. Our patient, risk-based approach is designed to protect and grow capital. We work hard to meet growth and income expectations year after year without increasing risk by chasing returns.
Combined with our own longevity as a business, this prudent way of managing money gives confidence to those we work with. They feel secure about making long-term plans and setting long-range targets — over decades in some cases — for us to achieve.
Direct access to your investment manager and regular meetings help your trustees to monitor investment performance and strategy. We provide complimentary training events for trustees, as well as giving thought leadership on key investment strategy issues through our white papers.
Our Charity Symposium is a key forum for discussing the latest investment trends and important developments in the charitable and not-for-profit sector, often with speakers who are experts in their field.
This film looks at the tools and solutions that are improving governance and leadership within civil society, as well as ideas that will shape the future of the profession. Watch the video here.


More on how small businesses are going global.
Facilitating small-business exports of goods and services is a top priority for the Small Business Administration and Export-Import Bank of the United States, which are following Obama administration goals to double exports by 2014.
The U.S. exported a total of $178 billion in goods and services in July -- an all-time high, according to data from the Bureau of Economic Analysis as cited by the Export-Import Bank.
In the Jobs Act signed into law in September 2010, President Barack Obama allowed for the SBA to increase its ability to provide export-related financing by raising SBA 7(a) loan limits to $5 million from $2 million on export-related loans.
The law made the SBA Export Express loan permanent, with a 90% guarantee for loans up to $350,000 and 75% for loans between $350,000 and $500,000, according to the SBA. It also provides three-year state grants of up to $90 million to help small-businesses owners grow the exporting side of their businesses.
In early August, the Export-Import Bank said it had hit a record $24.5 billion for export-related loan authorizations. The bank's financing supports more than $31.5 billion of export sales and 213,000 U.S. jobs, including 2,548 small-business export jobs.


Posted on March 9, 2015 by mark behnke	in Mark Behnke, New Perfume Reviews and tagged euphorium brooklyn cilice, euphorium brooklyn wald, reviews.
There are times most recently when I am presented with a marketing campaign for a new perfume brand where I can tell more time was spent on the publicity than the perfume. It has gotten so bad that the more elaborate the presentation the more my expectations plummet. It was with skepticism turned to maximum that I started to read through the materials from new independent perfume brand Euphorium Brooklyn. The founder of the line, Stephen Dirkes, has created a mythology around his perfumes where it is difficult to determine what is true and what is fiction. What was true for me was I had fun reading through it but I expected the perfumes to be not nearly as compelling. I was pleasantly surprised at how much I enjoyed Cilice and Wald the first two releases.
Based on the amount of fact-checking I could do I can't really confirm whether any of this is true and the press materials mention it is a combination of fiction and non-fiction. So what comes next is straight out of those press materials. The brand is based on the story of the Euphorium Bile Works which was founded in Brooklyn in 1860. There were three perfumers attached to the enterprise Etienne Chevreuil, Christian Rosenkreuz, and Rudolph Komodo. They are represented in the logo as the stag, bear, and dragon respectively. Each of the perfumers will have one of their perfumes reproduced for the brand. Cilice is by M. Chevreuil and Wald is by M. Rosenkreuz. The third fragrance will be called Usar by M. Komodo. One final bit from the background is M. Komodo invented a process by which the fragrances induce euphoria called, wait for it, The Komodo Process.
As I said it was all great fun to read through but I have to give the team behind Euphorium Brooklyn credit Cilice and Wald live up to this fanciful tale. They have a fascinating roughhewn unfinished quality. Usually I find it irritating but maybe this time they wore me down with a Komodo Mind Trick. Both Cilice and Wald are very simple but they are also fun.
To give you an idea of the prose on the website here is the description of M. Chevreuil's inspiration for Cilice, "Etienne sought to capture and convey the sensuality of the environment and intensity of emotion when a young nun is encountered in her cloistered cell. An intimate and ecstatic moment is observed as she becomes transcendent." When you read that you might expect a cold stone cell infused with incense amid the leather bound books on the acolyte's desk. That is exactly what Cilice delivers. There is no real development off of that mixture and that is what gives it a primal quality that I found particularly enjoyable. As for euphoria well this time The Komodo Process missed its target.
I can't even begin to reproduce the story of M. Rosenkreuz's inspiration for Wald. It is so broadly melodramatic that I couldn't stop laughing. Wald is another of these forest milieu fragrances that a number of independent perfume brands have undertaken recently. Wald is a simple scentscape of a forest containing cedar and pine with a bit of smoke from a fire hanging in the boughs while the scent of the decomposition rises up to meet it. This time The Komodo Process maybe had its way with me as Wald really hit a sweet spot for me and I really enjoyed the time I spent with it.
Cilice and Wald are perfume oils and as such they have 8-10 hour longevity but almost no sillage.
These perfumes are not anything terribly original or unique. They are well done and by making them oils they allow a wearer to have something quite bold on without projecting it around the room. I am looking forward to the last in the trilogy, Usar, because M. Komodo should have his process finely tuned in that one. In the meantime if you find me out wearing Wald or Cilice you might be able to convince me about a great deal on a bridge.
Disclosure: This review was based on samples provided by Twisted Lily.
Editor's Note: If you want to check out the website here is the link. Be warned subtle it is not.


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Gett ist ein Israelisches Unternehmen, das Fahrdienstleistungen online vermittelt.

Geschichte
Das ursprünglich als GetTaxi von den Unternehmern Shahar Waiser und Roi More 2010 in Israel gegründete Startup-Unternehmen hat im Rahmen einer Wagniskapital-Finanzierung über 520 Mio. US-Dollar eingenommen und wurde vom US-Wirtschaftsmagazin Forbes zu einem der "15 Unternehmen mit dem explosivsten Wachstum" gewählt.

Im Mai 2016 hatte sich die Volkswagen AG mit 300 Mio. US-Dollar (umgerechnet 267 Mio. Euro) an dem Gett beteiligt. VW-Vorstandsvorsitzender Matthias Müller nannte den Einstieg bei dem Fahrdienstleister einen Meilenstein in der Geschichte des Volkswagen-Konzerns. Zum Jahresende 2018 steigt VW aber vollständig wieder aus.

International hat das Unternehmen (Stand Mai 2016) 4000 Unternehmenskunden, welche die angebotenen Dienstleistungen nutzen. Mit etwa 50.000 eingesetzten Fahrern erwirtschaftete das Unternehmen 2015 einen Umsatz von 500 Mio. US-Dollar.

Konzept
Der Dienst kann über eine App für Smartphones sowohl mit dem Betriebssystem Android als auch iOS in Anspruch genommen werden. Eingesetzt werden nur Fahrer, die über eine offizielle Lizenz zur Personenbeförderung verfügen. Es ist möglich, den Aufenthaltsort des Fahrers und seine voraussichtliche Ankunftszeit zu ermitteln. Buchbar sind die Personenbeförderungen sofort oder im Voraus. Die Dienstleistung wird im Anschluss über Kreditkarte bezahlt.  Das Vermittlungsangebot umfasst neben der Personenbeförderung auch Lieferdienste und Logistikleistungen.

Vergleichbar mit seinem direkten Konkurrenten Uber bietet Gett mittlerweile seine Vermittlungsdienste in der Personenbeförderung weltweit in mehr als 60 Städten an, darunter London, Moskau und New York City. Gett möchte sich gegenüber seinen Konkurrenten in der Fahrdienstleistungsvermittlungsbranche unter anderem dadurch abheben, dass es seine Beförderungsentgelte stets auf dem gleichen Niveau halten will und nicht, etwa zu Stoßzeiten, seine Preise erhöht.

Einzelnachweise

Organisation (Personenverkehr)
Unternehmen (Israel)
Taxi
Organisation (Straßenverkehr)
Volkswagen
Gegründet 2010

redpajama_set_name: RedPajamaWikipedia


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Pedophile Who Abused 200 Children Stabbed To Death In Prison
One of the word's worst pedophiles, who abused up to 200 Malaysian children, has been stabbed to death in prison, according to The Sun.
Citing sources with knowledge of the matter, the publication reported that Richard Huckle, a Christian teacher from Ashford in Kent, England, was murdered at the HMP Full Sutton prison in Yorkshire on Sunday, the report said. He was stabbed to death with a makeshift blade and was found in his cell, according to the report.
In 2016, Huckle was given 22 life sentences for an unprecedented number of offenses against children from poor Christian communities aged between six months and 12 years.
The "Christian teacher" awarded himself "Pedopoints" for different acts of abuse against 191 children and sold images of his depravity on the dark web.
Huckle was arrested when he was stopped at Gatwick Airport en route to spend Christmas with his family in 2014, after Australian authorities tipped off the UK's National Crime Agency.
A stream of pictures and videos of his rapes and assaults on children were shared with pedophiles worldwide through the now-defunct dark website TLZ – The Love Zone.
Huckle first visited Malaysia on a teaching gap year when he was 19 and went on to groom more children posing as a respectable Christian English teacher and philanthropist.
Officers seized Huckle's encrypted laptop and, although he refused to hand over passwords, they managed to uncover 20,000 indecent pictures and videos.
They found Huckle's pedophile manual called Pedophiles And Poverty: Child Lover Guide and a "Pedopoints ledger" in which he awarded himself marks for the abuse of 191 girls and boys.
In online posts, Huckle bragged: "Impoverished kids are definitely much easier to seduce than middle-class Western kids."
Offering advice to other like-minded people, he wrote: "If you really want to fully embrace child love, poverty is the way to go."
He said middle-class children were protected "no-go areas" while the less privileged may be "ugly, ill-mannered and unhealthy", the court heard.
Commenting on one of his victims, he boasted: "I'd hit the jackpot, a 3yo girl as loyal to me as my dog and nobody seemed to care."
Huckle crowd-funded the release of indecent images of the three-year-old girl in exchange for Bitcoins, achieving 105% of his target.
His parents were so horrified when he confessed his crimes that they begged police to take him away and made statements to support his prosecution, the court heard.
Ahead of his sentencing, Huckle claimed to a psychiatrist that he wanted to put his "madness" behind him and settle down with a south Indian woman.
But the court was shown a posting from 2013 in which he outlined his plan to marry one of his victims in order to help him abuse more children.
In a message to TLZ's 7,000 users, he described how he had "fallen in love" with South Asia and its "adorable kids".
He wrote: "I have gotten particularly close with one family whom I have known about six years.
"I have sexual contact with four of the girls in that family and, though the family obviously does not approve it, they try to work around it as they know I can be a potentially valuable asset to them in the future."
On planning to marry one of the girls when she turns 18, he wrote: "I feel my situation could strongly benefit me in that my partner is still quite young and I have known her since she was seven and I can influence her young mind to mold her into the perfect wife.
"My ambition once married would be for our family to be like foster carers for children, temporary or long term."
A Prison Service spokesman confirmed that Richard Huckle had died but would not comment further while the police investigation was ongoing.
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Nintendo Switch DS? Dual screen model possibly revealed in firmware update
By Sean Riley published 15 April 20
Return of the dual-screen console
Nintendo had a big hit on its hands last year with the holiday release of the cheaper Switch Lite. Now signs point to a forthcoming higher-end version of the Switch that may bring back a second screen reminiscent of the Nintendo 3DS (via Metro).
Rumors of a more powerful version of the Switch have been swirling for some time, but the latest comes from a reference to a new hardware model found in the recent Nintendo Switch firmware update.
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The hardware model was identified in the firmware update as "nx-abcd," which aligns with previous development codenames for Switch models. While there isn't an abundance of details regarding the device, the one piece of info that sticks out is support for a secondary display.
Firmware 10.0.0 adds preliminary support for a new hardware model: "nx-abcd".3 of the 5 new DRAM profiles are for this new hardware type and there's evidence of a secondary display of sorts being added exclusively on this model. ( ͡° ͜ʖ ͡°)April 14, 2020
There is no indication as to what form that second screen will take. Given Nintendo's history, we imagine a clamshell-style dual-screen device like the Nintendo DS and 3DS. However, making a second screen such a prominent feature of a single higher-end variant of the console would seem like an odd rift to create for Switch game developers.
It's possible this could be a smaller secondary display that simply supports offloading some content, like item management or menus (think Wii U). And keep in mind, this is a minor piece of code in a firmware update so it's possible the final hardware won't have a second screen at all.
Nintendo has officially denied that a new Switch will be coming this year, so whatever the final form for this new Switch ends up being, we don't expect to see it until 2021.
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Sean Riley has been covering tech professionally for over a decade now. Most of that time was as a freelancer covering varied topics including phones, wearables, tablets, smart home devices, laptops, AR, VR, mobile payments, fintech, and more. Sean is the resident mobile expert at Laptop Mag, specializing in phones and wearables, you'll find plenty of news, reviews, how-to, and opinion pieces on these subjects from him here. But Laptop Mag has also proven a perfect fit for that broad range of interests with reviews and news on the latest laptops, VR games, and computer accessories along with coverage on everything from NFTs to cybersecurity and more.
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Laptop Mag is part of Future plc, an international media group and leading digital publisher. Visit our corporate site.


Are you planning to be a creative mind of the internet? Nothing could be simpler. It's enough to have a good idea, desire and the minimal skills needed for you to be able to communicate to others what you want to talk about. You do not have to be a technological genius - it's just your passion and desire that count. And from time to time - some good advice from other artists.
Such advice can be heard on StoryHive - a unique platform which brings together young artists of online content. Here you can get to know people just like you - full of passion, enthusiasm and willingness to pass their ideas on to others. On StoryHive not only will you be able to present your ideas and make them subject to initial criticism, but you will also learn many valuable things and refine your ideas. However, StoryHive isn't just a platform - it's also an interesting campaign for TELUS, which aims to support young artists. Creativity and the willingness to work have always been appreciated by TELUS, but this time there really is a lot at stake. In the second wave of this campaign, with the focus being on web serials, you can win up to $10,000 in project financing. With such money, not only will you be able to implement your ideas, but you will also be able to properly advertise them and start earning from them. If you want to learn more this topic, click on the video!


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The Crusading General
The Life of General Sir Bernard Paget GCB DSO MC
Julian Paget
16 pages of b&w illustrations
Bernard Paget enjoyed a hugely successful military career which culminated in his top level appointments in WW2. As C-in-C Home Forces and the C-in-C 21st Army Group he was responsible for preparing the Army for the long awaited Second Front in Europe in 1944. To his lasting chagrin he was not to use in battle 'the weapon' that he had shaped and tempered. He proved himself both a gallant soldier in the Great War and a shrewd commander in the dire conditions of the ill-fated Norway campaign.
It was as a trainer that he excelled and this ideally fitted him for his wartime appointments. An irascible, brusque and, at times, downright rude man, possibly due to constant pain from his war wounds, he nonetheless worked well with Alanbrooke (the CIGS) but he had, like many others, a stormy relationship with Monty who, to Paget's deep disappointment, took over 21st Army Group from him prior to D-Day. Paget was made Commander-in-Chief in the Middle East, a key post previously held by Wavell, Alexander and 'Jumbo' Wilson. This book throws fresh light on other major World War II figures.
After retiring in 1946 he pursued a full career both in education and charities. Although one of the most influential generals of his time, due to circumstances, and possible character, he was regarded as 'always the bridesmaid and never the bride'. But his contribution to victory cannot be overestimated.
Colonel Sir Julian Paget is an author and historian.
The Crusading General Reviews
The Mountain War
Dr Isaak Barasch
Mont Pincon
Eric Hunt
Walking In the Footsteps of the Fallen
Christina Holstein
Nazi Concentration Camp Commandants 1933–1945
Ian Baxter
Somme Offensive - March 1918
Andrew Rawson
Jeffrey Plowman
The Killing Fields of Provence
James Bourhill
The Battle for Budapest 1944 - 1945


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An 18-year-old begins dating a charming 50-year-old man who treats her to shopping sprees and fancy restaurants, creating a huge rift with her...
Miraculous World: New York, United HeroeZ (2020)
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Teen Parisian superheroes Ladybug and Chat Noir visit New York on a field trip and discover that superheroes exist in the United States too.
Miraculous World: Shanghai – The Legend of Ladydragon (2021)
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On school break, Marinette heads to Shanghai to meet Adrien. But after arriving, Marinette loses all her stuff, including the Miraculous that allows...
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Clawdeen Wolf, half human and half werewolf, has recently started attending Monster High, a school for monsters in all forms. After quickly...
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Over the objection of his girlfriend, Ben agrees to take a job as the "live in" man servant to a wealthy businesswoman, Amanda, but...
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Il distretto di Talas () è un distretto (audan) del Kazakistan con  capoluogo Qaratau.

Talas