text:
Angelo State University Graduation is Saturday
By Matt Trammell, Dec 6, 2022
SAN ANGELO, TX – Over 740 students are scheduled to walk the stage during Angelo State University's two fall commencement ceremonies on Saturday, Dec. 10, in the Junell Center/Stephens Arena, 2235 S. Jackson St.
Commencement Ceremonies:
9 a.m. - Graduates of the College of Education, the College of Science and Engineering, the Norris-Vincent College of Business, and the College of Graduate Studies and Research in those academic fields
12:30 p.m. - Graduates of the Archer College of Health and Human Services, the College of Arts and Humanities, and the College of Graduate Studies and Research in those academic fields
The doors to the Junell Center will open one hour prior to each ceremony. The ceremonies are open and free to the public, and may also be viewed live on the ASU website at angelo.edu/commencement.
ASU will confer and present 284 master's degrees and 460 bachelor's degrees during the commencement ceremonies Saturday.
There are 27 Master of Arts, eight Master of Professional Accountancy, two Master of Agriculture, 68 Master of Business Administration, 22 Master of Education, 131 Master of Science, four Master of Science in Nursing, 19 Master of Security Studies and three Master of Social Work degrees.
There are 47 Bachelor of Arts, three Bachelor of Applied Arts and Sciences, 77 Bachelor of Business Administration, 11 Bachelor of Fine Arts, six Bachelor of Intelligence and Analysis, 49 Bachelor of Interdisciplinary Studies, one Bachelor of Music, 176 Bachelor of Science, eight Bachelor of Science in Civil Engineering, 21 Bachelor of Science in Health Science Professions, eight Bachelor of Science in Mechanical Engineering, 37 Bachelor of Science in Nursing, 10 Bachelor of Security Studies, and six Bachelor of Social Work degrees.
On a related note, on Friday at 6:30 p.m., the ASU Nursing Department will conduct the annual Fall Pinning Ceremony for its graduates in the Houston Harte University Center. Nursing pinning ceremonies became a U.S. tradition in the early 1800s to mark students' completion of their education and entry into the profession.
BREAKING: Veteran San Angelo ISD Central High School Principal Bill Waters Announces His Retirement
01/27/2023 - 10:08 , by Ryan Chadwick
San Angelo ISD Produces Five All State Musicians
01/25/2023 - 14:42 , by Matt Trammell
Angelo State University to Offer Free Woodwind Instrument Techniques Day to Aspiring Musicians
01/25/2023 - 08:26 , by Yantis Green
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Why feds need to get better at studying IT best practices
By Alan P. Balutis
When it comes to IT, the federal government needs more case studies of successful projects delivered on time and within budget, writes Alan P. Balutis.
Alan P. Balutis is senior director and distinguished fellow at Cisco Systems' Internet Business Solutions Group.
The CIO Council has launched a best practices site to serve as an online learning and collaboration resource for IT management. It is part of the Obama administration's initiative to strengthen program management, as outlined in the 25-point reform strategy announced in December 2010 by Jeffrey Zients, deputy director for management at the Office of Management and Budget, and Federal CIO Vivek Kundra.
The council has tapped CIOs Michael Locatis (Energy Department), Chris Smith (Agriculture Department) and Teri Takai (Defense Department) to lead its new Management Best Practices Committee, which will maintain the site. Having once guided a similar best practices initiative for the council, I applaud this effort.
Kundra is on record as noting that the government does not have a sterling record in delivering quality IT solutions in a timely, cost-effective manner.
There are plenty of familiar examples of government IT programs suffering multimillion-dollar overruns, schedule slips measured in years and dismal mission-related results. In fact, only a few days before the site launched, Kundra testified during a Senate subcommittee hearing titled "Examining the President's Plan for Eliminating Wasteful Spending in Information Technology."
Senators and other witnesses cited a few familiar examples of programs that have gone off the tracks, including the electronic archives initiative at the National Archives and Records Administration, the handheld computer debacle in the 2010 census, and the Homeland Security Department's SBInet border initiative. Such examples are all too common.
Now consider the effect of that accretion of obituaries of so-called runaway systems. What are the consequences of creating a false image of a federal landscape littered with the remains of failed IT initiatives? What impressions do we create?
Let's make it a multiple-choice answer:
a) The American public and Congress get little in return for the more than $80 billion invested each year in IT in the federal government.
b) Most federal systems projects are rife with fraud, abuse, waste and mismanagement.
c) Most federal IT managers couldn't run a roadside vegetable stand if you spotted them the vegetables and had the highway patrol flag down passing drivers.
d) All of the above.
Organizational expert Herbert Kaufman once wrote, "One must understand sickness and death to understand health; pathology contains many of the clues to normality." He was arguing for the study of organizational terminations and eliminations as part of the public administration discipline.
But when it comes to the IT literature read by CIOs and program managers, just the opposite is needed. We excel at assembling autopsies. In looking at articles, publications and public testimony about federal IT, we have too few examples of projects delivered on time and within budget that also have the promised functionality. So instead, we have focused on our failures.
I once likened that approach to studying medicine by only doing autopsies. From that, we assemble guidance on what not to do, what problems and pitfalls to avoid. We have too few studies of healthy projects and successful systems implementations. We have too little guidance on what we should do and what has led to past successes.
CIOs ought to be documenting successful applications as an ongoing part of their responsibilities. I look forward to seeing the CIO Council's best practices website expand and grow to meet that need.
NEXT STORY: House panel probes White House staff's storing of mobile device messages

redpajama_set_name: RedPajamaCommonCrawl


Portrait of a gentleman in a red coat 1746c.
This portrait of a cheerful gentleman in a red coat is one of the more animated and more freely painted examples of Reynolds's work during an important transitional period of his career. This portrait, and other comparable contemporary examples, such as the Portrait of Robert Haswell (Walsall Museum and Art Gallery) show that at this date Reynolds was striking out in his own direction, away from the formulaic manner of his master Thomas Hudson, and exploring a more realistic, individual and characterful representation. The differences between this portrait, and the blander examples that Hudson and his followers were painting at this date is striking, and the degree to which Reynolds wished to escape their wooden formula is apparent even in such elements as his use of the framing feigned oval. This conventional device had been used in British portraiture at least as early as the decades either side of 1600, and allowed a sense of depth and recession as though the subject were being viewed through a window. Hudson and his followers applied the oval as a flat framing element, whose only purpose was to soften the rectangle of the canvas. Reynolds employed it fitfully in 1740s, but is generally content to let the sitter's space remain identical with that of that canvas. When he does use a feigned oval as here, he seems interested in its substance as a structure, applying depth and perspective to its elements, but the means by which Reynolds does this is more painterly than pure geometry. The free curves of the framing oval enliven the background and, tightening our focus on the sitter, permit a new psychological intensity.
The novelty of Reynolds's portraiture at this date, set against his former master Hudson and the mass of his contemporaries, lies in this greater emphasis on the study of character and psychology in his subjects – the very qualities that we now regard as inseparable from the purpose of portraiture. The lighting in this painting is also manipulated to the same ends, and the dramatic chiaroscuro is groundbreaking for British portraiture at this date, in which subjects were generally suffused in the bright, porcelain light of the rococo. The strong light falling on the sitter's face from the left, and the free, vigorous brushwork, create a feeling of movement, the sense that the gentleman has just turned abruptly to face that side, and a sense of character and purpose – the feeling that not only has the sitter just determined to speak but that what he might say is worth hearing.
The man's identity is not yet known. In the years after Reynolds left Hudson's studio in 1743 – his apprenticeship cut short after only three years due to a disagreement with his master – the young painter divided his practice between London and his native Devon, working from an address in Plymouth, where he enjoyed a good practice from this date with naval officers and their families. This gentleman may, therefore, have been one of the painter's old connections from Devon, or perhaps one of the first of the legion of patrons who were to pass through his studio in London. The freer painting of this portrait places it towards the very end of Reynolds's first English period, the years before he left for the Continent in 1749, and perhaps the gentleman sat to Reynolds at the new studio he took on in St Martin's Lane, the most fashionable address at the time for a society portrait painter. Already by this date the public had awoken to the quite exceptional talent that Reynolds exhibited, and in 1748 the November edition of the Universal Magazine listed him among fifty seven 'Painters of our own nation now living, many of whom have distinguished themselves by their performances, and who are justly deemed eminent masters'1. He was the youngest painter named, with the exception of Thomas Gainsborough, the rival with whom he would be linked for most of is life and into posterity.


text:
Resolutie 999 van de Veiligheidsraad van de Verenigde Naties werd unaniem door de VN-Veiligheidsraad aangenomen op 16 juni 1995, en verlengde de UNMOT-waarnemingsmissie in Tadzjikistan met een half jaar.

Achtergrond

Na de val van de Sovjet-Unie, werden in 1991 verkiezingen gehouden in Tadzjikistan. Begin 1992 kwam de oppositie in opstand tegen de uitslag – de oud-communisten hadden gewonnen – ervan. Er brak een burgeroorlog uit tussen de gevestigde macht en hervormingsgezinden en islamisten uit de achtergestelde regio's van het land, die zich hadden verenigd. In 1997 werd onder VN-bemiddeling een
vredesakkoord gesloten.

Inhoud
De gesprekken tussen regering en oppositie in Tadzjikistan verliepen goed. Zo was het staakt-het-vuren met drie maanden verlengd, tot 26 augustus. Beide partijen wilden het conflict oplossen en vreedzaam tot
nationale verzoening komen door concessies te doen en compromissen te sluiten. Ook had het GOS haar vredesmacht verlengd tot 31 december. Zowel
de partijen als de vredesmacht en de OVSE-missie hielden nauw contact met elkaar.

De Veiligheidsraad verlengde de UNMOT-waarnemingsmissie in Tadzjikistan tot 15 december, op voorwaarde dat het gesloten akkoord en het staakt-het-vuren in acht werden gehouden en de partijen bleven werken aan verzoening en democratie. Secretaris-generaal Boutros Boutros-Ghali werd gevraagd daar elke drie maanden over te rapporteren. De partijen moesten ook verder vertrouwen op bouwen door onder meer krijgsgevangenen uit te wisselen en vluchtelingen te laten terugkeren. De secretaris-generaal werd ook gevraagd verslag uit te brengen over zijn gesprekken met Afghanistan over een mogelijke kleine groep VN-personeel in het noorden van dat land. Er werd immers hevig gevochten aan de grens tussen Tadzjikistan en Afghanistan.

Verwante resoluties
 Resolutie 968 Veiligheidsraad Verenigde Naties (1994)
 Resolutie 1030 Veiligheidsraad Verenigde Naties
 Resolutie 1061 Veiligheidsraad Verenigde Naties (1996)

 0999
VR0999

redpajama_set_name: RedPajamaWikipedia


It is with great pleasure that we invite you to the Mobile Monday Yangon, on 26th JAN 2015.
Mobile Monday is a global event that started in Helsinki, Finland, which has since spread around the world. Yangon will be the latest city to feature one. It is an informal monthly event which enables mobile industry visionaries, developers, and influential individuals to share ideas and collaborate. Since April 2014, we have been hosting Mobile Monday one Monday per month, bringing together experts and enthusiasts alike to explore themes of topical interest to those of us in the mobile industry and other related fields.
2015, it's not just another year for Myanmar. The year is going to be filled with excitement and MobileMonday welcomes with a forward looking theme "Education & Talent". Education through Mobile covered by JoyDash, an educational gaming platform and Skills Needed for Mobile Industry by Frontier Technology Partners are just two parts of an exciting Monday evening.
Ko Thet Naing Swe, CEO of Joy Dash company, is going to talk about education through mobile. His company has been developing mobile apps for kids. Thura Soe Paing, CEO of Frontier Technology, will talk. We have foods and drinks. Come join us and enjoy the Monday!


Listen to Patti's new single Start Again or get it from iTunes!
Patti Russo's solo EP Xo!!
and three other tracks is out now!
After working with high-profile bands and musicians around the world for twenty years, singer / songwriter Patti Russo is launching her solo career with a tour of the UK and an EP of her own music.
Patti is best known as a duet partner for Meat Loaf, with whom she toured the world for two decades. She has also worked with Cher, Queen, Bryan Ferry, Betty Harris and the Trans-Siberian Orchestra, to name a few.
Patti Russo is also no stranger to the theatre stage, having appeared as Esmeralda in the London production of Notre-Dame de Paris and as Killer Queen in the Las Vegas production of Queen and Ben Elton's smash hit musical We Will Rock You.


Ever wanted to try vitamin C serum to get a young and healthy skin. Don't worry, we are not talking about the expensive and branded ones that are going to cost you a lot. But have you ever thought that you can actually make the serum at home all by yourself? Yes, you can use some really simple steps and easily available ingredients. But before all those things, we should actually need to know a bit about the Vit c serum and its benefits, so here we go.
How long does it take for vitamin c to work on skin?
How often to use vitamin c serum, vitamin c serum benefits?
How to make vitamin c serum with tablets?
A serum is an amber-colored, protein-rich liquid which separates out when blood coagulates. Vitamin C (also known as ascorbic acid) is the Beyoncé of skin care—it can do a lot of things flawlessly. It's an antioxidant. It helps reduce and prevent fine lines and wrinkles. It boosts collagen production.
Vitamin C serum thus undoubtedly has so many benefits, so do look at these benefits.
Natural vitamin c serum or a homemade Vitamin C serum works wonders on your skin and you can't just simply ignore the benefits that your skin will be getting through this serum. Many of us might really be having a question in our mind that does vitamin c serum really work? If you also have this question in your mind. Then definitely go through these wonderful benefits of vitamin c serum.
Take a look at some of the amazing skincare benefits that you are going to experience once you start adding this serum to your skincare routine.
Serums contain the highest concentration of active ingredients that you can purchase or get without the need for any kind of prescription. These are fillers and not killers. When we think and try to know a bit, cleansers and moisturizers contain just about 5-10 % of active ingredients while serums contain about 70 % of active ingredients. This means the active ingredients present in the serums will help your skin in getting an even tone. Serums even help you in reducing the fine lines and dark spots.
If you think your skin is very sensitive and is more prone to breakouts, then you must definitely be taking care by avoiding cheap occlusive agents. Serums are more like delivery systems and all they do is a simple delivery thing. They take the active ingredients present in them that are the peptides, stem cells, vitamins and beneficial minerals. Serums take these ingredients and help in delivering them deep down under the skin. These may thus help your skin being potent and pure as well.
Is vitamin c serum good for acne? This is probably the question that is juggling in many people's head and if your head is one of it. Then stay tension free as this serum is watery consistency and unlike many other moisturizers it is not oil based. This means serums absorb very quickly into your skin without any kind of breakout.
Many of the people who suffer from the oily skin problem end up making their problem even problematic by trying some various things like using moisturizers and all. Serums work magic on your skin as they help you in keeping your skin hydrated. So, your sebaceous glands won't be bothered about producing sebum. This makes your skin less oily.
It may sound weird to you. But there is a logic behind this subheading and I am going to explain to you. You might be thinking that how can be going with serums be a money saving idea. Yes, it is a wise money investment as it will help you and save you from wasting your money on various other multiple skin care products that you might not be satisfied with. So, choose the perfect serum for your skin.
When you add Vit C serum to your skin care routine, you will start seeing some noticeable changes and improvements in your skin. It usually takes about three weeks for the serum to take full effect but it also depends upon the skin type.
The best way to use a topical vitamin C is to simply apply a small amount of it once or twice a day (depending on your skin type) to clean dry skin. It should be applied before you begin applying your makeup (give it time to dry), but after you use your daily facial toner (should you choose to use one).
This is probably the most searched thing by the skin care enthusiasts and after knowing the above-mentioned benefits of Vit C serum, then you must also be looking for the DIY vitamin c serum with tablets. So, here we present you the process with simple steps.
Homemade vitamin c cream and serums are ultimate for skin care and you will definitely need to start using this serum to experience it.
We hope and wish you have learnt pretty much about the serum and its various benefits. Homemade vitamin c serum reviews aren't needed, so juts give it a try and share with us your vitamin c serum before and after photos.
A feminist by thoughts. She would love to have discussions about anything. Always ready to take up new challenges that comes her way. With a Masters degree in Commerce, she is into blogging and is thoroughly enjoying it. As a foodie, she would love to taste various foods. She loves to watch food and travel shows.
#Valentine's Day – How to Make this Valentine Day a Special One!


text:
Basil Al-Araj, Terror Activist or Young Intellectual? Haaretz's Changing Story
By: Hanan Amiur, Tamar Sternthal March 26, 2017
Palestinian Basil Al-Araj was buried last Thursday near Bethlehem.
Why was Al-Araj killed in the prime of his youth?
Haaretz readers who saw the article by Jack Khoury and Gili Cohen ("Palestinian teenager shot and killed by IDF forcces near Hebron") in the March 19 print edition, or March 18 online here, would understand that Israeli forces killed him because he supported the boycott of Israel and opposed Palestinian security coordination with Israel.
As the online edition stated:
The two funerals took place a day after the funeral of Basil al-Araj. Araj was shot and killed by police special forces on March 6 in Al-Bireh after they surrounded the house in which he was hiding. Araj, who Israel defined as a wanted person, was among the leaders of the boycott movement in the West Bank, and called for an end to security cooperation between Israel and the Palestinian Authority, and his death led to protests against the PA. During the funeral hundreds called for revenge and an end to security cooperation with Israel.
Similarly, the print edition reported:
While the article mentions al-Araj's support for the boycott movement, both versions – online and in print – fail to mention critical information reported by Gili Cohen and Jacky Khoury earlier this month at the time of the shootout in which Al-Araj was killed ("Palestinian Gunman Killed in West Bank Shootout with Israeli Soldiers," screen shot follows).
As Cohen and Khoury reported March 6, al-Araj "was the leader of a cell planning attacks and was responsible for acquiring weapons, a statement from the Border Police said." Why did the March 19 article mention al-Araj's involvement in the boycott movement but ignore his alleged involvement in planning attacks and acquiring weapons? The latter activities are the cause for the deadly arrest raid. The former is not.
In addition, as Cohen and Khoury reported March 6, but not March 19, al-Araj was killed in an arrest raid, in which the suspect opened fire on Israeli troops. They wrote March 6: "A Palestinian gunman was killed early Monday in an exchange of fire with Israeli security forces during a raid to arrest him. . . " The later story does not mention that the purpose of the raid was to arrest al-Araj. Nor does it mention that al-Araj opened fire on the police.
Moreover, Cohen and Khoury reported on March 6 that "the Israeli army reported that two M-16 and Carlo rifles were found during a search of al-Araj's home." This information also did not appear in the March 19 article, which did find space to mention the irrelevant information that al-Araj was a younger intellectual who supported the boycott movement.
About the March 19 omissions concerning al-Araj's reported involvement in terror activity, Haaretz news editor Ori Mark told Presspectiva, CAMERA's Hebrew site:
The Al-Araj case is mentioned as an aside in a news story about the killing of a Palestinian youth. The article stated that Israel regarded him as wanted, and that he was killed in the house in which he was hiding. The article published after he was killed explicitly stated that according to the border police, he was the leader of a cell planning attacks. There is no basis to the claim that Haaretz attempted to misrepresent the circumstances of the incident.
Following Presspectiva's publication of this post in Hebrew, Haaretz publisher Amos Schocken tweeted in Hebrew: "When [Presspectiva editor-in-chief] Hanan Amiur sees a chance to tell an eighth of the truth, which is worse than a lie, or when he's plain lazy, he fails to note that the digital edition in both languages carried the full report."
Amiur responded by posting screen shots of the articles, which in both Hebrew and English ignored the fact that the border police identified al-Araj as the head of a terror cell and were attempting to arrest him when he fired on them. Amiur tweeted: "When Amos Schocken claims that the digital editions of both languages carried full reports, we will provide screen shots from the digital edition (in two languages) and the public will decide who is telling one-eighth of the truth."
For the Hebrew version of this post, please visit Presspectiva.
CAMERA Prompts Washington Post Correction on 'Occupied Gaza'
The Washington Post Soft-Pedals Discredited Anti-Israel U.N. Report
Hanan Amiur Hanan Amiur is Editor-in-Chief of Presspectiva (CAMERA's Israel Department). A journalist and media critic, Amiur was a columnist for the prestigious Israeli media commentary magazine, The Seventh Eye, and wrote for several Israeli daily newspapers including Ma'ariv and Yisra'el Hayom. Amiur writes about Israeli media coverage of current events and is a regular commentator on Channel 20 and Radio Eretz.
Basil Al-Araj


Move up in the world at the Ledge. Experience rock climbing, one of the world's fastest growing indoor sports. The controlled environment means you can climb day or night, regardless of weather conditions.
The Ledge Climbing Centre offers over 300 metres of textured walls up to 8 metres high and a variety of vertical and overhanging wall systems complete with aretes, roofs and slabs.


text:
Q: MongoDB search multiple Field in multiple subDocument My MongoDB data structure looks like this:
    {
        "id": "7118592",
        "passages": [
             {
                 "infons": {
                     "article-id_pmid": "32292259",
                     "title": "Keywords",
                     "type": "front",
                     "section_type": "TITLE"
                  },
                  "text": "Understanding of guidance for acupuncture and moxibustion interventions on COVID-19 (Second edition) issued by CAAM"
             },
             {
                 "infons": {
                     "section_type": "ABSTRACT",
                     "type": "abstract",
                     "section": "Abstract"
                 },
                 "offset": 116,
                 "text": "At present, the situation of global fight against COVID-19 is serious. WHO (World Health Organization)-China Joint Mission fully confirms the success of \"China's model\" against COVID-19 in the report. In fact, one particular power in \"China's model\" is acupuncture and moxibustion of traditional Chinese medicine. To better apply \"non-pharmaceutic measures\":the external technique of traditional Chinese medicine, in the article, the main content of Guidance for acupuncture and moxibustion interventions on COVID-19 (Second edition) issued by China Association of Acupuncture-Moxibution is introduced and the discussion is stressed on the selection of moxibustion device and the duration of its exertion."
             }
         ]
    }

I want to request the article-id_pmid and the text in the same subdocument, also the text of subdocument which contains in infons a field with section_type : ABSTRACT and type: abstract.
I had tried this request but the result was not what I am searching for:
db.mydata.find({$and:[{"passages.infons.article-id_pmid$":{$exists: true}},{"passages.infons.section_type":"ABSTRACT"},{"passages.infons.type":"abstract"}]},{"passages.infons.article-id_pmid.$":1,_id:0, "passages.text":1})

A: Each of the top-level conditions is treated independently.
Use https://docs.mongodb.com/manual/reference/operator/query/elemMatch/ to specify multiple conditions on the same array element.

redpajama_set_name: RedPajamaStackExchange


text:
2016's top golf stories: Palmer's death, Johnson's Open
Larry Bohannan
The 2016 year was not a kind year in terms of music, with so many great names in music like David Bowie, Glenn Frey and Prince dying and breaking the hearts of millions of fans. But music went on in the year, even in the shadow of the deaths.
So it was in golf this year. Yes, there were wonderful stories of victories and comebacks and surprises. But they were all overshadowed by the passing of one of the best-known and most-loved sports figures of all time.
Here's one list of the top five golf stories of 2016:
1. The death of Arnold Palmer: Few figures in golf have towered over the game itself like Palmer, who died in September just weeks after his 87th birthday. From his 62 career PGA wins to his seven major titles to his importance in reviving the British Open to his memorable rivalry with Jack Nicklaus, Palmer on the golf course was a force to be remembered. But it was Palmer the person who seemed to have the biggest impact on people. A firm handshake, a legible autograph and a sparkling smile made people feel even more of a connection with Palmer than watching him play and being part of Arnie's Army, his legion of fans. The outpouring of emotions from throughout the golf world on Palmer's passing showed how important he was to the game.
ALSO READ: There was a lot of movement n OWGR in 2016
2. Dustin Johnson's big year: For years, Johnson was known as a remarkably talented but underachieving player who knew how to lose major championships, not win them. After a spring of near misses, Johnson broke through for his first major win at the U.S. Open. That was followed by a World Golf Championship victory and later a win in the FedEx Cup playoffs. Suddenly talk of a Big Three in golf with Rory McIlroy, Jordan Spieth and Jason Day was replaced by the idea of a Big Four. Johnson ends the year as the No. 3 player in the Official World Golf Rankings.
3. Ariya Jutanugarn's LPGA season: When Jutanugarn bogeyed the final three holes to lose the ANA Inspiration at Mission Hills Country Club in Rancho Mirage, it might have been easy to think that the Thai star was still young and learning to win. Instead, Jutanugarn won her next three starts, becoming the first player to win her first three LPGA starts in three consecutive events. She later added two more wins, including the Women's British Open for her first major title. By the end of the year, she had passed Lydia Ko in wins for the season and won the LPGA Player of the Year award. All of this happened for Jutanugarn before her 21st birthday.
ALSO READ: A dozen golf balls for Christmas? You can do better
4. The USGA and rules: The final round of the men's U.S. Open was certainly painful to watch knowing that the United States Golf Association was in the middle of a big controversy over its rules at its biggest event. It was the latest in a long line of embarrassing rules situations for the USGA, and it was the second time in Johnson's history that a final-round rules discussion loomed over his own play. In the Open, Johnson was eventually penalized a stroke for accidentally causing a ball to move on a green (Johnson self-reported the incident and said he did not make the ball move). By the end of the year, the USGA was talking about simplifying the rules, and they even fast-tracked a change to the rule that caused Johnson to be penalized.
5. The United States wins the Ryder Cup: Having won six of the last seven Ryder Cups, the European team could have been confident in Minnesota in September. But the European team had six rookies, the Americans had a renewed confidence behind popular captain Davis Love and the event turned into a bit of a rout. The U.S. team won 17-11 behind inspired play from players like Patrick Reed, Phil Mickelson and Dustin Johnson. Reed's battle with Rory McIlroy in singles and Mickelson's brilliant match against Sergio Garcia in singles will be remembered for years.


text:
El Partit Comunista Peruà va ser fundat en el 8 d'octubre de 1928 per José Carlos Mariátegui amb el nom de "Partit Socialista", sent integrant de la Internacional Comunista. En 1930 sent Eudocio Ravines Secretari General canvia de nom per "Partit Comunista Peruà". En 1964 es produeix una escissió, ocasionant que el partit quedi en mans de la facció pro soviètica, que va rebre el nom del seu setmanari:"Unitat". Mentre que el grup que es va separar (pro-pekinès) va prendre el nom de "Bandera Vermella", capçalera de la seva publicació.

El Partit Socialista Peruà
El 7 d'octubre de 1928, José Carlos Mariátegui (Secretari General 1928 -1930), juntament amb Julio Portocarrero, Avelino Navarro, César Hinojosa, Fernando Borja, Ricardo Martínez La Torre i Bernardo Regman funden el Partit Socialista Peruà (PSP), partit marxista, anti-feudal i anti-imperialista, que va tenir en els seus inicis una clara influència de Mariátegui que proposava construir a Amèrica Llatina un socialisme "sense calc ni còpia" que sigui aplicada a la realitat concreta de cada país encara que sense deixar de ser classista i marxista, una altra particularitat era que tenia com a principals actors no solament al proletariat sinó també a la pagesia. El PSP asseuria les bases per a la creació de la Confederació General de Treballadors del Perú (CGTP) i tindria una gran influència en el moviment obrer.

En 1929 els delegats del PSP, Hugo Pesce i Julio Portocarrero exposen "El Problema de les races" plantejat per Mariátegui, a Buenos Aires i Montevideo al congrés de la facció llatinoamericana de la III Internacional, no obstant això la III Internacional va acabar per descartar les tesis de Mariátegui, les mateixes que caurien en l'oblit en el si del PSP després de la mort de Mariátegui.

El PCP i els seus inicis
Després de la mort de Mariátegui en l'any 1930, Eudocio Ravinez –que després seria expulsat del partit convertint-se en un ferri anticomunista- assumeix la conducció del PSP, que canviaria el seu nom a Partit Comunista Peruà (PCP), adherint-se completament a les doctrines i directrius de la Tercera Internacional.En la dècada del 30, el PCP va ser declarat il·legal i perseguit per l'oligarquia governant, d'aquesta manera el PCP va ser primerencament desmantellat per la repressió governamental de Leguía i Sánchez Cerro, en aquesta època van morir per la repressió diversos militants i dirigents, sent considerats com els primers màrtirs del partit. En l'any 1936 es va il·legalitzar al PCP impedint-los participar en les eleccions. En l'any 1939 van donar suport a la candidatura de Manuel Prado Ugarteche (1939-1945) arran d'una directiva de la III Internacional que cridava a la creació de fronts antifeixistes durant la II Guerra Mundial.

En els anys 1942 i 1946 el PCP celebra el seu primer i segon Congrés, respectivament, en els quals s'allunya cada vegada més de ser un partit revolucionari de masses, tenint poca influència en la vida política nacional en la qual el APRA es convertia en el partit més popular, així i tot el PCP tenia gran influència en sindicats i universitats. El moviment social i el PCP sofreixen gran repressió durant la dictadura militar de Manuel A. Odría (1948-1956)

El cisma
En els 60 el PCP s'incorpora gradualment a la legalitat i més aviat els grups revolucionaris com el Front d'Esquerra Revolucionària (FIR) es formaven al marge del partit, els esdeveniments revolucionaris com la revolució cubana, les guerrilles guevaristes, el trotskisme, etc. crea no solament partits nous, sinó també escissions dins del PCP, formant-se nous partits o grups revolucionaris d'esquerra, aquests grups passarien a ser part del que es va conèixer com la "nova esquerra" dels anys 60.

L'Exèrcit d'Alliberament Nacional
El caràcter burocràtic i col·laboracionista del PCP va decebre a molts dels seus militants especialment dels joves universitaris els qui veien en les guerrilles guevaristes la forma d'arribar al poder i instaurar el socialisme. En 1962 una facció se separa i en 1963 funda, amb militants dissidents d'altres partits, l'Exèrcit d'Alliberament Nacional peruà (ELN), dirigit per Héctor Béjar, Juan Pablo Chang i el poeta Javier Heraud, convertint-se així en un dels primers grups guerrillers del Perú.

"Pro soviètics" i "maoistes"
Però l'escissió més important encara no s'havia donat i va tenir els seus inicis a l'estranger: En 1963 ocorre la ruptura entre el Partit Comunista de la Unió Soviètica (PCUS) i el Partit Comunista Xinès (PCCh) que rebutjava la doctrina de Coexistència Pacífica dels soviètics la mateixa que havia estat adoptada també pel PCP. No obstant això el partit tenia ja forta influència maoista i aquesta divisió es veuria reflectida també en el PCP.

Així en 1964 el PCP es divideix en dues faccions, els "pro soviètics" partidaris de la Coexistència Pacífica liderats per Jorge del Prado (Secretari General de 1960 a 1991) i els maoistes liderats per Saturnino Parets, els segons com a Bandera Vermella a causa del nom de la seva publicació oficial. El PCP col·laboraria amb el govern de tendència esquerrana prosoviética del militar Juan Velasco Alvarado (1968-1975), període que es coneixeria com el Govern Revolucionari de les Forces Armades. En 1978 ocorre una nova escissió, es forma el Partit Comunista del Perú - Majoria (PCP – Majoria) liderada per Ventura Zegarra segons ells de tall soviètic per diferenciar-se del eurocomunismo que assenyalaven havia adquirit el PCP.

El PCP i l'Esquerra Unida
El govern del General Francisco Morales Bermúdez (1975-1980), de tendència més dretana va atreure el descontentament popular i davant les massives protestes es va veure obligat a cridar a una Assemblea Constituent per 1978 i a eleccions per 1980, els partits polítics, incloent els marxistes, tornen a la legalitat i el PC que para llavors tenia gran influència en el moviment obrer, especialment en la Confederació de Treballadors del Perú participa sense aliats en les eleccions obtenint sis curules (escons) en l'Assemblea.

No obstant això ja es veia com una necessitat la unió de l'esquerra que, en conjunt, havien obtingut una important presència en l'Assemblea, el PC s'uneix amb el Partit Socialista Revolucionari (PSR) i altres grups d'esquerra per fundar la Unitat d'Esquerres (UI), la resta de l'esquerra fundo altres fronts i aliances per participar en les eleccions presidencials de 1980.

Després de les eleccions presidencials de 1980, l'esquerra legal es decideix ajuntar per a les eleccions municipals de novembre i funda l'Esquerra Unida (IU), sent el PC un dels membres fundadors juntament amb el PSR, PCR Classe Obrera, FOCEP, UNIR, UDP i el PCP-Pàtria Vermella entre altres, guanyant l'IU importants alcaldies al país i en les eleccions de 1983 van guanyar l'alcaldia de Lima amb Alfonso Barrantes, així l'IU es convertia una de les principals forces polítiques del país.

D'altra banda Sendero Luminoso (PCP-SL) va iniciar en els 80 la seva lluita armada, considerant al PC i a la resta de l'esquerra com a revisionistes, atacant moltes vegades als seus principals dirigents i entrant en oberta confrontació amb ells.

El PCP
El PCP es va afeblir durant la dècada dels 90, la dissolució de la URSS i per tant del PCUS –el seu principal aliat a l'estranger- així com conflictes a l'interior d'IU van ser dos durs cops que sofria, mentre l'IU es dissolia, quedant gairebé la totalitat d'aquests partits al marge de l'escena política nacional, encara que el PCP Unitat va seguir mantenint la seva influència en la CGTP. En 1991 Renán Raffo Muñoz seria triat secretari general, càrrec que ocupa fins al 2007. Al febrer del 2008 és triat secretari general el Magíster Roberto De la Cruz Huaman.
És necessari assenyalar que a partir del congrés s'inicia el desastre intern i polític en el qual va tenir una important responsabilitat el fins a aquest llavors secretari general:Jorge del Prado.
En les eleccions presidencials del 2006 participen en aliança amb el Front Ampli d'Esquerra – Moviment Nova Esquerra (FAI-MNI) i al no arribar a la segona volta electoral li donen el seu suport al candidat nacionalista Ollanta Humala. Des del 2012, forma part del Front Ampli per Justícia, Vida i Llibertat

Membres Prominents
 Julio Portocarrero, un dels fundadors del PSP i secretari general del partit de 1937-1940.
 Gamaniel Blanco, considerat com el primer màrtir del PCP, va morir en 1932 després d'una golpiza donada per militars durant una repressió al moviment obrer i miner; va morir a la presó en el Callao. Poeta, mestre i lluitador social.
 Pompeyo Herrera, dirigent estudiantil membre del PCP, mor a causa de les tortures dels militars en 1933.
 Simón Herrera Farfán, dirigent del PCP, elegit diputat pel Cusco en 1936, és capturat i torturat després d'una revolta obrera, morint a causa d'això en 1953.
 Jorge del Prado Chávez, secretari general, primer de 1946 a 1948 i després de 1960 a 1991.
 Raúl Acosta, empresonat en 1960 al govern de Manuel Prado. Prèviament, armen un complot des del govern, tot per trencar relacions amb Cuba dels barbuts.,
 Pedro Huilca Tecse, Secretari General de la CGTP i membre de la direcció nacional del PCP, va morir assassinat pel destacament PUJOL el 18 de desembre de 1992.
Anteriorment a Raul Acosta i Jorge Del Prado, va ser Secretari del partit comunista del Perú, Jorge Acosta Sales, per molts anys i empresonat en el Cep i a Lima, co fundador de la CGTP. Lluitant a principis contra la iniciada del sector pekines per desarticular el veritable PCP.

El seu habitatge en Echenique 335, Magdalena Del mar, va ser atacada i pintat diverses vegades pels de la línia Maoista. També va ser directe col·laborador de Jose Carlos Mariategui i Hugo Pesce.
 Alejandro Olivera Vila, dirigent oriünd de Moya, Huancavelica, va ser Diputat Constituent i Diputat de la República del Perú per 12 anys (1978-1990)

Òrgans de Premsa
El PCP - Unitat compta amb una pàgina en internet: www.pcperuano.com i publica el periòdico UNITAT.

Diagrama del fraccionament del Partit Comunista Peruà

Notes

Bibliografia
 Informe de la Comissió de la Veritat i de la Reconciliació (CVR). Capítol: Els Partits d'Esquerra.
 José Carlos Mariátegui. Ideologia i Política. 15.ª. Edició Llima 1985. Ed. Amauta.
 Nestor Kohan. Ni calc ni còpia: Assajos sobre el marxisme argentí i llatinoamericà. Versió electrònica en Rebelion.org.
 Lumbreras i uns altres, Nova història general del Perú. 3.ª. Edició Llima 1985. Mosca Blava Editors.
 Documents varis del PCP-Unitat i del PCP-Pàtria Vermella.

Enllaços externs
 Pàgina Web Oficial del Partit Comunista Peruà

Partits comunistes peruans


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Holly sure knows how to tell a story.
This idea of Holly"s now doesn"t seem like a good idea to Chris. Not only is he her doll for playing dress up with actual dresses, but there"s the risk someone they know could see two Hollys.
Holly"s having a lot of fun with her twin/doll/changeling/boyfriend. She has him put on everything dress she likes until she finds a winner for the Homecoming dance. Chris will be happy when she"s finally the one wearing the dress.


The Fall River Police Department's Professional Standards unit is compromised of one Detective Lieutenant and one Detective that are assigned by the Chief of Police and work under his direct command. The Professional Standards Unit's primary function is to thoroughly investigate complaints and ensure the integrity of our department as well as act as a liaison to the media.
The Fall River Police Department must provide citizens with a fair and effective avenue for redress of legitimate complaints against its officers. The Professional Standards Unit also protects the members of the Department by investigating and dismissing false and unfounded allegations of misconduct. The Professional Standards Unit also assures that each officer receives every protection he/she is entitled to under both the state and Federal Constitutions.
The Professional Standards Unit's function is vital for the maintenance of professional conduct with the Fall River Police Department. The integrity and professionalism of the Department is in direct proportion to the integrity and discipline of each of its members. The public image of the Department is largely determined by the quality of the Professional Standards Unit's function in responding to allegations of misconduct by the Department or its members.
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It is of utmost importance to the administration of the Fall River Police Department to provide citizens of Fall River with a quality of police services citizens that ensures the utmost integrity of all employees.
To ensure that this level of service is continually provided to citizens, it is recognized that there must be a method for the administration to be made aware of citizen's complaints regarding actions or inactions of sworn or civilian employees of this department, that fail to meet the standards required.
It is the policy of the Fall River Police Department to accept and investigate all complaints of misconduct or wrongdoing against the Department or Department employees, regardless of the source of such complaint, by conducting a regulated, thorough and impartial examination of all available factual information.
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British Medical Association chair James Johnson has resigned over not fully being able to express the anger felt by junior doctors over the MTAS appointments system. Mr Johnson said Association members were unhappy over a letter he recently sent to The Times. BMA treasurer Dr David Pickersgill said that the letter was felt to be insufficiently sensitive and had led to a loss of confidence in Mr Johnson.


text:
The Reformation at 500: Grappling with Martin Luther's anti-Semitic legacy
Opinion: On the Reformation's 500th anniversary, what lessons have been learned from the virulent but influential hatred of a foundational church figure?
By Michael Coren October 25, 2017
An antique print of Martin Luther in his study at Wartburg Castle in Eisenach (lithograph), 1882. (GraphicaArtis/Getty Images)
Michael Coren is a journalist and broadcaster and the author of 16 books.
It's party time in the religious world. On Oct. 31, Christians—or, to be more precise, Protestant Christians, with a surprising amount of support from the Vatican—celebrate the 500th anniversary of the Reformation, when legend has it that German monk and professor Martin Luther nailed his 95 Theses on the door of the castle church in Wittenberg, thus lighting the fuse that blew European Christendom apart.
It matters far more than one might think, because it was not only religion but politics, culture, and economics that would change in that hammering's wake. In the document, Luther made public his condemnation of the sale of indulgences—money paid to reduce the time spent in purgatory, a sort of waiting room before heaven, by relatives and loves ones. But this academic disputation went further than that, and it was a manifesto of criticism aimed at Roman Catholicism. History, as it were, was given a reboot.
There is much that is positive about Luther. He liberated people from rigid church control, gave impeccable energy to the idea of the individual's relationship with God, and worked to eliminate corruption and superstition. In many ways, he was a pioneer not just of religious change, but of modernity.
But behind his undeniable genius was a gritty nastiness. He could be crude, abusive, angry, and, perhaps most tragically, profoundly anti-Semitic—a legacy that needs to be grappled with, even 500 years later.
He started as a supporter of the Jewish people, arguing quite rightly that they had been badly treated by the Roman Catholic Church, and quite wrongly that they, if presented with what he regarded as a more authentic Christianity, would surely convert. In 1523 he wrote an essay, entitled "That Jesus Was Born a Jew," condemning the fact that the church had "dealt with the Jews as if they were dogs rather than human beings; they have done little else than deride them and seize their property."
But the Jews did not convert, and Luther reacted appallingly. In 1543, he published "The Jews and Their Lies," which today is shocking in its venom, and even for its time stood out as particularly cruel and intolerant. In the 65,000-word treatise, he calls for a litany of horrors, including the destruction of synagogues, Jewish schools and homes; for rabbis to be forbidden to preach; for the stripping of legal protection of Jews on highways; for the confiscation of their money. The Jews are, wrote Luther, a "base, whoring people, that is, no people of God, and their boast of lineage, circumcision, and law must be accounted as filth."
Some of his defenders have claimed that Luther was old and ill when he wrote this, ignoring the fact that he lived another three years after the essay and that most of us become mildly grumpy when we feel unwell, not genocidal. Plus, Luther had also managed to have the Jews expelled from Saxony and some German towns as early as 1537.
And regardless of his intentions, Luther's thinking on the Jewish people had a direct impact on history: The Nazis amplified Luther's anti-Semitism from the earliest days of the National Socialist movement. It helped in the creation of the heavily Nazified and racist faction of Deutsche Christen, or German Christians, within the German Lutheran church, but perhaps more significantly, partly enabled the culture of anti-Semitism that made the Holocaust possible.
One especially repugnant case is that of Martin Sasse, the Bishop of the Evangelical Church of Thuringia during Kristallnacht in 1938. He feted the pogroms and the mass destruction of synagogues and Jewish businesses, and even tied it explicitly to Luther himself; just days after what was in effect the beginning of the organized slaughter of the Jews, he distributed a pamphlet entitled Martin Luther on the Jews: Away with Them! in which he claimed the Nazis were acting as Christians in their violent anti-Semitism, and that this was precisely what Luther would have wanted.
Yes, there was also a powerful anti-Nazi movement within Lutheranism, and the sacrifice and even martyrdom of those pastors and laypeople must never be forgotten. The Confessing Church, for example, was formed in opposition to the regime's attempt to unify all German Protestants into a single pro-Nazi church. Leaders like Martin Niemoller and Heinrich Gruber were sent to concentration camps but survived; writer and activist Dietrich Bonhoeffer, who was accused of being part of a plot to assassinate Adolf Hitler, did not.
But Luther was not unique in his Christian anti-Semitism. It's such a grotesquely paradoxical reaction, of course; Jesus and most of the founders of Christianity were Jewish, but many of those claiming to love Him have hated His race and people. St. John Chrysostom, a major influence on the Eastern Orthodox Church, was virulently anti-Semitic; in 1555, Pope Paul IV issued a bull removing the rights of the Jews and subjecting them to communal humiliation. The examples are, alas, legion. Christians deliberately expunged the Jewishness of their faith and thus distorted it and shamed the teachings and life of that 1st-century Jewish preacher from Galilee. It's a birth defect of the historic church, and it didn't take very long for early Christian leaders to join the club—and while Luther did not codify his hatreds into tangible church policy, he left a heritage of antagonism and hostility all the same.
But 500 years later, have lessons been learned and wounds healed? Is the world a better and kinder place now because Christians have realized their colossal failures, stemming from one part of the church's founding figures? It's a layered answer. The Roman Catholic Church formally rejected its doctrinal anti-Semitism at the Second Vatican Council in 1965, and Catholics have worked diligently and genuinely to build bridges with the Jewish world since then. And outside of fringe conservative movements within the church, Rome has been largely successful. Protestantism is diverse by its very nature. Evangelical conservative Christians frequently adopt a Christian Zionist stance and are passionate supporters of Israel, even if often for mangled reasons; the underlying theology looks to the world's Jews moving to Israel en masse, thus hastening the second coming and the end times. Lots of fire and mayhem to come—sinners beware.
Liberal Protestantism, including most Lutherans, is less absolute. In 1994, the 5-million-member Evangelical Lutheran Church in America spoke publicly of Luther's "anti-Judaic diatribes" and denounced "the violent recommendations of his later writings against the Jews." The Central Council of Jews in Germany had long asked for a formal statement from Lutherans on the subject of anti-Semitism, and just last year, the Lutheran Church in Germany obliged, condemning Luther's writings on the Jews and "the part played by the Reformation tradition in the painful history between Christians and Jews." The state Lutheran churches in Norway and the Netherlands have followed suit.
Other Lutheran churches reacted earlier; the American Lutheran Church, for instance, acknowledged it as early as 1974. In 1998, on the 60th anniversary of Kristallnacht, the Evangelical Lutheran Church in Bavaria issued a declaration that "it is imperative for the Lutheran Church, which knows itself to be indebted to the work and tradition of Martin Luther, to take seriously also his anti-Jewish utterances, to acknowledge their theological function, and to reflect on their consequences. It has to distance itself from anti-Judaism in Lutheran theology."
The situation is confused by the situation in the Middle East. Progressive churches have been some of the first to admit and condemn past anti-Semitism, but have been equally bold in criticizing Israel, sometimes stridently. Informed critiques of certain Israeli policies is certainly not the same as anti-Semitism, in spite of what some zealots might have us believe, but there are times when attacks on Israel by Lutherans, the United Church and other liberal Protestants do seem to lack historical context and sensitivity to the Jewish experience, and seem more angry at the Jewish state than committed to a greater social and international justice. There have, for example, been numerous motions and even decisions to boycott and disinvest from Israel while at the same time brutal Muslim theocracies have been largely ignored.
Put simply, one of the prime reasons for the creation of Israel in 1948 was because European Christians had acted against their faith and persecuted the Jewish people. It's imperative that Christians understand that, but it's unclear that enough of them do. But for all that, the twin solitudes of Jews and Christians were broken down long ago. William Temple, for example, became Archbishop of Canterbury in 1944 and helped co-found the Council of Christians and Jews; in 1943, he spoke out in the House of Lords about the Nazi persecution of the Jews, insisting that, "We at this moment have upon us a tremendous responsibility. We stand at the bar of history, of humanity and of God." That type of stance has been replicated and applauded myriad times since then and now, thank God, flows through the bloodstream of contemporary denominations. When in 2008 Lord Jonathan Sacks, the chief rabbi of the Commonwealth, publicly referred to the Archbishop of Canterbury and the Archbishop of York as "beloved colleagues," he meant it. When in 1986 John Paul II entered Rome's Great Synagogue, the first Pope since St. Peter to enter a Jewish place of worship, the emotion was genuine.
As a Christian with three Jewish grandparents, I have hardly ever experienced any anti-Semitism in the church. But as I celebrate this 500th anniversary, I will do so with reservations. Not because I regret the Reformation—far from it—but because the otherwise sparkling lens that Luther provided is not, for me and I know for many others, completely clear. And that's so terribly sad.
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FILED UNDER: Catholic church Catholicism Christianity Editor's Picks Evangelical Lutheran Church Martin Luther Opinion Reformation religion


Department of Obstetrics and Gynecology, University of Patras, Medical School, Rion, Greece.
Copyright: Androutsopoulos G© 2015. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
The epidermal growth factor system (EGF System) is present in various human organs. It has 4 receptors (EGFR, ErbB-2, ErbB-3 and ErbB-4) and numerous ligands. Especially in cancer, the epidermal growth factor system signaling network becomes hyperactivated with a variety of mechanisms (ligand overproduction, receptor overproduction, constitutive receptor activation).
ErbB receptors are trans-membrane glycoproteins. Dimerization of ErbB receptors leads to intracellular kinase activation and initiates intracellular signaling via several pathways.
Due to the inactive status of postmenopausal endometrium, we expect to find significantly higher expression of the 4 ErbB receptors in endometrial cancer tissue.
In unselected endometrial cancer patients, there is EGFR expression in 43-67% of cases. EGFR overexpression in patients with Type I endometrial cancer, did not affect disease progression. However EGFR overexpression in patients with Type II endometrial cancer, associated with high grade disease and adverse clinical outcome.
In unselected endometrial cancer patients, ErbB-2 amplification/overexpression represents a rare event. ΕrbB-2 overexpression especially in patients with Type II endometrial cancer, is an indicator of a highly aggressive disease with poor overall survival.
Recent years ErbB receptors (especially EGFR and ΕrbB-2) have a particular importance, as they are potential targets in endometrial cancer treatment.
The epidermal growth factor system (EGF system) is present in various human organs [1, 2]. It has an important role in cell proliferation, differentiation and apoptosis during embryogenesis and postnatal development [1, 2].
Dysregulation of the EGF system signaling network is involved in cancer, diabetes, autoimmune, inflammatory, cardiovascular and nervous system disorders [1, 3].
Especially in cancer, the EGF system signaling network becomes hyperactivated with a variety of mechanisms (ligand overproduction, receptor overproduction, constitutive receptor activation) [3,4].
Furthermore, the EGF system in cancer contributes in proliferation, transformation, angiogenesis, migration and invasion . Recent years the receptors of the EGF system, are potential targets in cancer treatment [6, 7].
The EGF system has 4 receptors (EGFR, ErbB-2, ErbB-3 and ErbB-4) and numerous ligands [1,4, 5].
ErbB receptors are trans-membrane glycoproteins and belong to the superfamily of Receptor Tyrosine Kinases (RTKs) [1, 5]. They have an extracellular region with two ligand-binding domains, an extracellular juxtamembrane region, a hydrophobic transmembrane domain and an intracellular domain with tyrosine kinase activity [4, 8]. They catalyze the transfer of the γ phosphate of ATP to the hydroxyl groups of tyrosines in target proteins .
The extracellular region of EGFR, ErbB-3 and ErbB-4 has 2 distinct conformations. The closed conformation of extracellular region is inactive. The open conformation of extracellular region, is active and permits interactions with a ligand . In the absence of ligand binding, there is an equilibrium between the 2 conformations that favors the closed conformation [8, 10-12].
Ligand binding stabilizes the extracellular region in the open conformation, leads to the formation of homodimeric and heterodimeric ErbB receptor complexes and activates ErbB receptors by an allosteric mechanism [8, 11-14]. That leads to intracellular kinase activation and initiation of downstream signaling pathways [4, 13, 15]. However, ErbB-3 has no intrinsic tyrosine kinase activity and initiates signaling only in association with another ErbB receptor, usually ErbB-2 .
The extracellular region of ErbB-2 has a conformation not suitable for ligand binding . However, ErbB-2 is capable for ligand independent dimerization and signaling [8, 17]. ErbB-2 heterodimerizes with other ErbB receptors and is their preferred heterodimerization partner [4, 13, 17]. Moreover, at elevated expression levels ErbB-2 homodimerizes .
Ras/Raf/mitogen-activated protein kinase (MAPK) pathway (regulates cell proliferation and survival) [Figure 1] [19, 20].
Phosphatidylinositol 3-kinase (PI3K)/Akt pathway (regulates cell growth, apoptosis, tumor invasion, migration and resistance to chemotherapy) [Figure 1] [21, 22].
Signal transducers and activators of transcription (STAT) pathway (regulates oncogenesis and tumor progression) [Figure 1] .
Src Kinase pathway (regulates cell proliferation, migration, adhesion, angiogenesis and immune function) [Figure 1] [24,25].
Phospholipase Cγ/protein kinase C pathway [Figure 1] [26, 27].
Figure 1. Signaling pathways of ErbB receptors [4, 13, 15, 19-27].
Due to the inactive status of postmenopausal endometrium, we expect to find significantly higher expression of the 4 ErbB receptors in EC tissue .
EGFR localized to the basal part of surface epithelial cells, only in stromal cells, or both, of epithelial and stromal cells of endometrium [29-36]. It is primarily located in the cell membrane but also located in the cytoplasm [28, 32-40].
In unselected EC patients, there is EGFR expression in 43-67% of cases [32-34, 36, 38-43]. In patients with Type I EC, there is EGFR expression in 46% of cases . In patients with Type II EC, there is EGFR expression in 34-50% of cases [34, 35, 42, 44, 45].
ErbB-2 localized base-laterally in the glands and surface epithelial cells of endometrium [6, 29, 46]. It is located to the cell membrane [8, 28, 32-36, 39, 47].
In unselected EC patients, ErbB-2 amplification/overexpression represents a rare event . In patients with Type I EC, there is ΕrbB-2 receptor overexpression in 8% of cases and Erb-2 gene amplification in 1.4-3% of cases [42, 48]. Although ΕrbB-2 amplification/ overexpression is ore common in patients with type II EC, the exact frequency remains controversial [34, 35, 42]. Moreover, there are racial differences regarding ErbB-2 overexpression in patients with type II EC . ErbB-2 overexpression is more common in Black race patients with type II EC .
In patients with papillary serous EC, there is ΕrbB-2 receptor overexpression in 18%-80% of cases and ΕrbB-2 gene amplification in 17-47% of cases [34,35, 42, 48, 50-52]. In patients with clear cell EC, there is ΕrbB-2 receptor overexpression in 33% of cases and ΕrbB-2 gene amplification in 16-50% of cases [34, 35, 42, 48, 51].
ErbB-3 localized to surface epithelial cells of endometrium [31,-36, 53, 54]. It is located in the cytoplasm, with membrane staining in a minority of samples [28, 32-36, 54].
ErbB-4 localized to epithelial and stromal cells of endometrium [31-36, 54, 55]. It is located in the cytoplasm, with membrane staining in a minority of samples [28, 32-36, 54].
Recent years, the clinical role of ErbB receptors (especially EGFR and ΕrbB-2) in EC patients, have increasing popularity [35, 36, 42, 44, 45, 56-58].
EGFR may have a dual role in EC . EGFR overexpression did not affect disease progression in patients with type I EC, although affects disease progression in Type II EC . More specifically EGFR overexpression in patients with Type II EC, associated with high grade disease and adverse clinical outcome [34, 35, 42, 44, 45].
Moreover, ΕrbB-2 overexpression especially in patients with Type II EC, is an indicator of a highly aggressive disease with poor overall survival [34, 35, 44, 45, 47, 48, 50, 59, 60].
ErbB-3 overexpression in patients with EC, has an unclear clinical role and not well studied [28, 32, 35, 44, 45, 54, 61]. The clinical role of ErbB-4 in patients with EC, is poorly understood and not well studied [28, 32-35, 44, 45,54, 62]. It is obvious that ErbB receptors (especially EGFR and ΕrbB-2) in EC patients, are potential targets of molecular targeted therapies [35, 36, 42, 44, 45, 56, 58, 63]. Anti-ErbB MoAbs (cetuximab, panitumumab, trastuzumab, pertuzumab) may be an attractive treatment option, especially in EC patients with advanced, recurrent or metastatic disease and overexpression of EGFR and ErbB-2 [6, 7, 34-36, 44, 56, 64, 65].
However, a phase II study (NCT00392769) failed to demonstrate significant activity of cetuximab in unselected EC patients with advanced or recurrent disease [66, 67]. The clinical efficacy of trastuzumab in EC, has been reported in several case reports [64, 68-70]. However, a phase II study of Gynecologic Oncology Group (GOG-181B) failed to demonstrate significant activity of trastuzumab in unselected EC patients with advanced or recurrent disease and overexpression of ErbB-2 . Moreover, an ongoing randomized phase II study (NCT01367002) evaluates the efficacy of carboplatin/paclitaxel with or without trastuzumab in selected EC patients (papillary serous) with advanced or recurrent disease and overexpression of ErbB-2 .
ErbB-specific TKIs (gefitinib, erlotinib, lapatinib, afatinib) may be another attractive treatment option in EC patients with advanced, recurrent or metastatic disease and overexpression of EGFR and ErbB-2 [34-36, 44, 45, 56, 73-75]. However, a phase II study of the Gynecologic Oncology Group (GOG-229C) failed to demonstrate significant activity of gefitinib in unselected EC patients with persistent or recurrent disease . Also, a phase II study (NCIC IND-148) failed to demonstrate significant activity of erlotinib in unselected EC patients with advanced or metastatic disease .
Moreover, a phase II study of the Gynecologic Oncology Group (GOG-229D) failed to demonstrate significant activity of lapatinib in unselected EC patients with persistent or recurrent disease . It is obvious that ErbB-targeted therapies have only modest effect in unselected EC patients [34, 35, 44, 45, 56, 58, 63, 76]. Further studies into the molecular pathways of EC, may increase our knowledge regarding ErbB receptors and ErbB-targeted therapies [34, 44]. Perhaps the clinical role of ErbB receptors is more important in type II EC patients [34, 35, 44, 45, 47, 48, 50, 59, 60]. Also, ErbB-targeted therapies may be more effective as adjuvant treatment in type II EC patients with EGFR and ErbB-2 over expression [35, 36, 42, 44, 56-58, 64, 68, 69, 71-81].
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Create an R interface to an existing Weka learner/filter, or show the available interfaces.
a character string giving the fully qualified name of a Weka learner/filter class in JNI notation.
NULL (default), or a character vector giving the names of R classes the objects returned by the interface function should inherit from in addition to the default ones (for representing associators, classifiers, and clusterers).
a named list of special handler functions, see Details.
a character string naming a Weka package to be loaded via WPM.
make_Weka_associator and make_Weka_clusterer create an R function providing an interface to a Weka association learner or a Weka clusterer, respectively. This interface function has formals x and control = NULL, representing the training instances and control options to be employed. Objects created by these interface functions always inherit from classes Weka_associator and Weka_clusterer, respectively, and have at least suitable print methods. Fitted clusterers also have a predict method.
make_Weka_classifier creates an interface function for a Weka classifier, with formals formula, data, subset, na.action, and control (default: none), where the first four have the usual meanings for statistical modeling functions in R, and the last again specifies the control options to be employed by the Weka learner. Objects created by these interfaces always inherit from class Weka_classifier, and have at least suitable print and predict methods.
make_Weka_filter creates an interface function for a Weka filter, with formals formula, data, subset, na.action, and control = NULL, where the first four have the usual meanings for statistical modeling functions in R, and the last again specifies the control options to be employed by the Weka filter. Note that the response variable can be omitted from formula if the filter is unsupervised. Objects created by these interface functions are (currently) always of class data.frame.
Certain aspects of the interface function can be customized by providing handlers. Currently, only control handlers (functions given as the control component of the list of handlers) are used for processing the given control arguments before passing them to the Weka classifier. This is used, e.g., by the meta learners to allow the specification of registered base learners by their base names (rather their full Weka/Java class names).
In addition to creating interface functions, the interfaces are registered (under the name of the Weka class interfaced), which in particular allows the Weka Option Wizard (WOW) to conveniently give on-line information about available control options for the interfaces.
list_Weka_interfaces lists the available interfaces.
Finally, make_Weka_package_loader generates init hooks for loading required and already installed Weka packages.
It is straightforward to register new interfaces in addition to the ones package RWeka provides by default.
## Create an interface to Weka's Naive Bayes classifier.


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3Adobe Photoshop Elements 15 Classroom in a Book is the most thorough and comprehensive way for you to master all the new features in Adobe's top-rated consumer-targeted photo-editing software. Each chapter in this step-by-step, lesson-based guide contains a project that builds on your growing knowledge of the program, while end-of-chapter review questions reinforce each lesson. You will learn the basics of editing your images with Photoshop Elements and learn how to best use the program's many new features.
In this new version of the book you will receive complete coverage of all the new and improved features in Photoshop Elements 15. Discover how to use Smart Tags and enhanced search to make it faster and easier to organize and find your photos. Save time with the enhanced Instant Fix feature. Explore all new Guided Edits. Explore the Filter Gallery. You'll discover new tools that let you expand your creativity. And you'll learn how to print, export, and share your images.


text:
https://www.newstimes.com/news/article/Anthony-DeMattei-88-had-family-in-New-Milford-107037.php
Anthony DeMattei, 88, had family in New Milford
Published 1:00 am EST, Wednesday, February 4, 2009
Anthony R. DeMattei, 88, of Newtown, died Jan. 31, 2009, at his home after a long illness. He was the husband of the late Anna (Leonardo) DeMattei.
He was born April 3, 1920, in Brooklyn, N.Y., son of the late Giacomo and Virginia (Fusco) DeMattei.
He attended Brooklyn Poly Tech and graduated from the University of Bridgeport with a degree in mechanical engineering.
Before his retirement, Mr. DeMattei was in charge of Latin American operations for the Berol Corp. and was instrumental in the building of what was the Eagle Pencil Co. plant in Commerce Park, Danbury.
A resident of Newtown since 1958, he was a communicant of St. Rose of Lima Church and previously served on the Newtown Planning & Zoning Commission and the board of directors of Danbury Hospital.
Mr. DeMattei is survived by a son, Anthony J. DeMattei and his wife Laura of New Fairfield; a daughter, AnneMarie DeMattei of Middlebury; two sisters, Lucille DeMattei of Foster, Mass. and Teresa Johnson of Clinton, Mass.; four grandchildren, James Reynolds of New Milford, Danae DeMattei of New Fairfield, Emmett Kinsella of Tampa, Fla. and Devin Kinsella of Middlebury; and several nieces and nephews.
The Honan Funeral Home of Newtown was in charge of arrangements.
Memorials maybe made to the American Heart Association , 1 Union St., Suite 301, Robbinsville, NJ 08691.
Madeline Keating, 94, had daughter in New Milford
Jean Boorsch, 102, had family in New Milford
Walter Kench, 89, was former New Milford resident
Eugene Verrastro, 77, had family in New Milford
Eunice Alberta Talbot Rowland


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Q: ocaml vim : user-setup does not work I have installed the package user-install for ocaml (via opam)
1) opam install user-setup
2) opam user-setup install  (it will update .vimrc).
But, when invoking vim, I got error due to function not known in .vimrc :
systemlist.
And I fail to see if systemlist is part of vim's function.
Any clue ?

A: systemlist() was introduced in 7.4:248, and a serious bug with it was fixed in 7.4:256, so if it's possible to update your Vim to that patch or later it should solve your problem.


text:
16 Chinese Art And Its Markets A Tremulous Present What For The Future
Tefaf afternoons
Chinese Art and its Markets: A Tremulous Present, What for the Future?
For the art world, China has been the site of growth and opportunity over the past decade. Hong Kong, in particular, has solidified its position as the hub of the Asian art market and rivals New York and London as a global art capital. But recent protests have brought simmering political issues to a boil and to international attention. US-China trade tensions persist with no signs of conciliation, as the US imposed a new 15 percent tax on artworks originating from China on September 1st.
This panel of art and economic experts takes stock of the current critical state of relations between mainland China and Hong Kong and considers the implications for the future.
Boon Hui Tan
Vice President, Global Arts and Cultural Programs and Director, The Asia Society Museum
Gady Epstein
China Affairs Editor, The Economist
Kejia Wu
Faculty, Art Business Program, Sotheby's Institute of Art
Natasha Degen
Professor and Chair, Art Market Studies, Fashion Institute of Technology


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How One Chicagoland Company is Driving the Future
By Charlie Wojciechowski	• Published at 5:55 pm on April 19, 2011
It looks more at home on the set of a science fiction movie than the streets of Chicago, but the eStar truck could be the future of the delivery van.
The zero-emission, 100 percent electric truck is now being rolled out by Warrenville-based Navistar.
EStar trucks are designed from the ground up to be electric vehicles. The batteries ride between the frame rails beneath the load floor that can support more than two tons of cargo
Navistar's director of sales for eStar took us for a ride in the smooth-sided vehicle on a rainy Tuesday morning through crowded Chicago traffic. Our driver had no problem maneuvering in often-competitive Michigan Avenue traffic. T
he 70kw motor develops 102 horsepower, but because it is electric, it feels quick. It is also agile.
"It's built on a very narrow chassis," Mark McGrew said. "Getting through narrow streets is no problem."
The eStar can go 100 miles on an overnight charge. A monitor on the dashboard shows how much juice you have left and how your driving can extend the vehicle's range.
Every time you take your foot off the accelerator, the eStar's regenerative braking system kicks in recharging the batteries.
Navistar manufactures the eStar in Wakarusa, Ind. in a joint venture with UK-based Modec Vehicles.
eStars are already in service with companies like Fed Ex, Pacific Gas and Electric and the Canadian Post.
The cost is about three times that of a traditional gas-powered delivery truck, but McGrew said the low and relatively consistent cost of electric power makes the eStar more economical to operate.
Pure electric vehicles like the eStar can also lower a company's carbon footprint. The company estimates the vehicle can displace 876 gallons of fuel every year it's driven.


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Q: .NET Core Windows Service CultureInfo configuration I'm currently working on a .NET Core Windows Service, implementing a couple of BackgroundService classes to run stuff on a timer.
All is working perfectly bar one thing - writing a date to the ILogger reference appears to be using an incorrect Culture (en-US) rather then the system-configured en-AU.
For example -
    public override Task StartAsync(CancellationToken cancellationToken)
    {
        var utcNow = DateTime.UtcNow;
        Logger.LogInformation("Started at {utcNow}", utcNow);
        return base.StartAsync(cancellationToken);
    }

Will produce the log -

Is there a way in a Windows Service/Console app to set the Culture? I have used UseRequestLocalization ASP.NET Environment but it didn't seem logical in context as there would be no request.
I have tried setting all kinds of CultureInfo... properties with no result - any help would be appreciated.
Entry point Program class for reference -
public class Program
{
    public static void Main(string[] args)
    {
        CreateHostBuilder(args).Build().Run();
    }

    public static IHostBuilder CreateHostBuilder(string[] args)
    {

        return Host.CreateDefaultBuilder(args)
                .UseWindowsService()
                .ConfigureLogging((hostContext, logging) =>
                {
                    DBLoggerConfiguration config = hostContext.Configuration.GetSection("Logging").Get<DBLoggerConfiguration>();
                    logging.AddDBLogger(config);
                })
                .ConfigureServices((hostContext, services) =>
                {

                    services.AddHttpClient<ISMSService, TwilioSMSService>();
                    services.AddHostedService<ExpirationSchedule>();
                    services.AddHostedService<BillingSchedule>();
                });
    }
}

EDIT:
It appears through some digging in the Github repo the LogValuesFormatter responsible for formatting parameters within the message only uses CultureInfo.InvariantCulture - which leans heavily on the American way of formatting dates etc.
There appears to be no way to configure this, so I have submitted a bug in the Github repo which will hopefully get some backing - https://github.com/dotnet/extensions/issues/3380

A: Apply this setting at this point!
    public static void Main(string[] args)
    {
      CultureInfo.DefaultThreadCurrentCulture = new CultureInfo("pt-BR", true) { DateTimeFormat = { ShortDatePattern = "dd/MM/yyyy", FullDateTimePattern = "dd/MM/yyyy HH:mm:ss", LongTimePattern = "HH:mm:ss" } };

      CreateHostBuilder(args).Build().Run();
    }