text:
Q: Why I cannot connect android and PC through socket? I just started my first android application and have some troubles. I already have server code written in C++ in Qt. Since now I was using another console application as a client and everything works correctly. Now I'm trying to make a client part on my android (Android Studio). I want the client to be connected when I'll press the button. Only connection - no data exchange etc. When client (android) will be connected server should display communicate.
Here is how my server connecting func. looks like:
 SUCCESSFUL = WSAStartup(MAKEWORD(2,1), &WinSockData);
 sock_CONNECTION= socket(AF_INET, SOCK_STREAM, IPPROTO_TCP);
 memset(& ADDRESS, 0, sizeof(ADDRESS));
 ADDRESS.sin_addr.s_addr = inet_addr("127.0.0.1");
 ADDRESS.sin_family = AF_INET;
 ADDRESS.sin_port = htons(9090);

void Server::Connect()
{
bind(sock_CONNECTION, (SOCKADDR*)&ADDRESS, sizeof(ADDRESS));
listen(sock_CONNECTION,1);
SOCKET accept_Socket =0;
while(accept_Socket==0)
{
    accept_Socket = accept(sock_CONNECTION, NULL, NULL);
}
std::cout << "Client connected" << std::endl;
sock_CONNECTION=accept_Socket;
}

UPDATE: /I changed IP as you said in a comment/
Client's code. There are no fatal errors, just application is doing nothing.
Code:
Socket socket;
  public void onClick(View v) {
                try {
                    socket = new Socket("192.168.0.227", 9090);
                } catch (IOException e) {
                    e.printStackTrace();
                }

Errors:
Failed to set EGL_SWAP_BEHAVIOR on surface 0xaa23f380, error=EGL_SUCCESS
java.net.SocketException: socket failed: EACCES (Permission denied)
    at libcore.io.IoBridge.socket(IoBridge.java:619)
    at java.net.PlainSocketImpl.create(PlainSocketImpl.java:198)
    at java.net.Socket.startupSocket(Socket.java:584)
    at java.net.Socket.tryAllAddresses(Socket.java:128)
    at java.net.Socket.<init>(Socket.java:178)
    at java.net.Socket.<init>(Socket.java:150)
    at com.example.nataliah.client_testapp.Client_Connection$1.onClick(Client_Connection.java:26)
    at android.view.View.performClick(View.java:5198)
    at android.view.View$PerformClick.run(View.java:21147)
    at android.os.Handler.handleCallback(Handler.java:739)
    at android.os.Handler.dispatchMessage(Handler.java:95)
    at android.os.Looper.loop(Looper.java:148)
    at android.app.ActivityThread.main(ActivityThread.java:5417)
    at java.lang.reflect.Method.invoke(Native Method)
    at com.android.internal.os.ZygoteInit$MethodAndArgsCaller.run(ZygoteInit.java:726)
    at com.android.internal.os.ZygoteInit.main(ZygoteInit.java:616)
Caused by: android.system.ErrnoException: socket failed: EACCES (Permission denied)
    at libcore.io.Posix.socket(Native Method)
   at libcore.io.BlockGuardOs.socket(BlockGuardOs.java:282)
   at libcore.io.IoBridge.socket(IoBridge.java:604)

UPDATE 2 After adding permission to network I received those errors + the old ones:
android.os.StrictMode$AndroidBlockGuardPolicy.onNetwork(StrictMode.java:1273)
                                                                                at libcore.io.BlockGuardOs.connect(BlockGuardOs.java:110)
                                                                                at libcore.io.IoBridge.connectErrno(IoBridge.java:137)
                                                                                at libcore.io.IoBridge.connect(IoBridge.java:122)
                                                                                at java.net.PlainSocketImpl.connect(PlainSocketImpl.java:183)
                                                                                at java.net.PlainSocketImpl.connect(PlainSocketImpl.java:163)

A: Most probably your application does not have permissions necessary to access the network. Try adding
<uses-permission android:name="android.permission.INTERNET"/>

inside the <manifest> tag in your AndroidManifest.xml


text:
Catherine G. Wolf (* 25. Mai 1947 in Washington, D.C.; † 7. Februar 2018 in Katonah, Westchester County, New York) war eine US-amerikanische Psychologin und Informatikerin. Sie wurde bekannt durch ihre Forschung auf dem Gebiet der Mensch-Computer-Interaktion.

Leben und Werk
Wolf studierte Psychologie an der Tufts University und erhielt ihren Abschluss an der Brown University. Danach absolvierte sie ein zusätzliches Aufbaustudium am Massachusetts Institute of Technology, bevor sie dort als Vollzeit-Forscher begann. 1968 heiratete sie den Mathematiker Joel Wolf, mit dem sie zwei Töchter bekam. Sie promovierte in Psychologie bei Peter D. Eimas an der Brown University und wurde 1977 Managerin bei den Bell Laboratories for Human Factors. 1985 begann sie ihre Tätigkeit als Forschungspsychologin am Thomas J. Watson Research Center in Yorktown Heights, New York. Während ihrer Zeit bei IBM war sie besonders daran interessiert zu lernen, wie Menschen am Arbeitsplatz mit Software umgehen. Als Reaktion auf das von ihr beobachtete Verhalten entwarf und testete sie neue Schnittstellensysteme, in denen Sprache und handgeschriebene Wörter in digitale Informationen umgewandelt werden konnten. Sie arbeitete unter anderem an einem System namens Conversation Machine, dem Vorläufer der heutigen Telefonbanking-Systeme. 1997 wurde bei ihr Amyotrophe Lateralsklerose (ALS) diagnostiziert. 2001 entschied sie sich für eine Tracheotomie, bei der ein Atemschlauch dauerhaft im Nacken angebracht wurde, sodass sie ohne Verwendung von Nase oder Mund atmen konnte. Sie verlor schließlich den Gebrauch aller ihrer Muskeln außer einigen in ihrem Gesicht. Zur Kommunikation verwendete sie ein Computersystem, das die Bewegung ihrer Augenbrauen in Text umwandelte. Sie schrieb Gedichte, sandte E-Mails, führte Interviews und schrieb Artikel. 2004 ging sie in den Langzeiturlaub für Behinderte und trat 2012 offiziell in den Ruhestand. Auch nachdem sie fast alle Muskelfunktionen verloren hatte, leistete sie dennoch einen Beitrag zur Erforschung der Mensch-Computer-Interaktion. Sie arbeitete auch mit dem Wadsworth Center, das zum New York State Department of Health gehört, als Testerin verschiedener Systeme zusammen.  2009 veröffentlichte sie einen Forschungsartikel, der eine Skala erweitert, die üblicherweise zur Beurteilung des Fortschreitens von ALS (als ALSFRS-R bezeichnet) verwendet wird, um die Fähigkeiten von Menschen mit fortgeschrittenem ALS genauer einzuschätzen. Dieses Papier trug wesentlich zum Verständnis dessen bei, wozu ALS-Patienten in der Lage sein könnten, auch wenn ein Großteil ihrer Muskelfunktion verloren gegangen ist. Mit dem Verlust ihrer Muskelkontrolle wurde sie zunehmend zu einer Expertin für Gehirn-Computer-Interface-Systeme. Sie veröffentlichte mehr als 100 Forschungsartikel und besaß das Eigentum an sechs Patenten. 2003 wurde sie von der Tufts University mit einem Distinguished Service Award ausgezeichnet.

Weblinks

 Researchgate Profil
  Veröffentlichungen
 Catherine Wolf, 70, Dies; Studied How People and Computers Interact
 I Will Be Heard!
 channeling ada: catherine wolf, master communicator
 Poetry by guest blogger Dr. Cathy Wolf
 COUNTY LINES; A Thing or Two to Say Before Dying

Informatiker
Psychologe
US-Amerikaner
Geboren 1947
Gestorben 2018
Frau

redpajama_set_name: RedPajamaWikipedia


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text:
New York Times CEO Mark Thompson says there will still be a print paper in 10 years, but he's really into virtual reality
Harvard Business Review editor-in-chief Adi Ignatius (L) interviews Mark Thompson, CEO of The New York Times, at Business Insider's 2015 IGNITION conference.
Business Insider IGNITION 2015
Mark Thompson became CEO of The New York Times in 2012 after serving multiple roles at the BBC for over 30 years. While there, he worked his way up to Director-General, a position with the responsibilities of chief executive and editor-in-chief. He launched many successful shows on the BBC and oversaw the UK's leading on-demand subscription service. Since moving to Times, Thompson has seen digital subscribers grow to over one million. At Business Insider's IGNITION 2015 conference, Harvard Business Review editor-in-chief Adi Ignatius talks with Thompson about the future of The Times and digital media and advertising.
Edited for length and clarity.
Adi Ignatius: So this session is called 'The Survivor.'
Mark Thompson: I saw that.
AI: Did you pick that name? It seems aspirational.
MT: It's certainly not my name.
AI: So let's just jump right into it. I would say for The Times — more than maybe any other publication — all the transitional experimental things you do, the whole world is watching. We're all watching very closely. The experimentation is interesting. It seems a little bit like you're throwing stuff against the wall to see what sticks. What is the strategy we're seeing play out?
MT:I'll give you two or three examples. We really want to innovate and be at the edge and be seen to be at the edge of innovation in storytelling. We think storytelling is deep in the blood supply of The New York Times. And that takes us directly to things like, a couple years ago, "Snow Fall," the idea of rich multimedia storytelling. It takes us this year to virtual reality. So the idea of how do you innovate specifically around journalistic storytelling is a thread behind many of the experiments.
The Times' print subscribers received Google Cardboard to watch virtual reality films.
Karyne Levy/Business Insider
A second example would be a perception that in the 1980s we, The New York Times, broadened from being a news and opinion offering to all sorts of culture and lifestyle offerings in new sections. And in the transition to digital that slightly got lost in the wash. And so we're trying to get back to that sense of a broader engagement with our users' lives.
A third example would be a sense that part of what makes the physical New York Times tick, and has always made it tick, is the sense of a must-have daily experience of a core of really engaged users who can't really function without it. So how do you create that kind of frequency of use and habituation in a smartphone context?
So I would say there are two or three strategic themes very much based on our sense of our brand and our relationship with our readers, our users. And we're experimenting about how you transition those themes. That plays out in all sorts of different ways. So cooking, we're now working on our 'Well' app and so on, these are ways of trying to express those themes. But they're all about adding value to users, trying to answer user issues and to deliver something which is worth paying for, even if some of it's free, that it all would be worth paying for.
AI: So on the topic of audience development, how has that changed the process in the newsroom?
MT: Well firstly, there was a question mark 15 months ago — when we started introducing techniques, and exposing our colleagues to audience data — about whether there would be complete cultural rejection of this or whether it would lead to kind of untoward editorial decisions and cat videos everywhere and all the rest of it. It just hasn't been like that. I think if Dean Baquet were sitting next to me, I think he'd say the same thing: it's been a really interesting and positive thing. Something the entire organization can get behind is the idea that every single person in the Times wants as many people as possible to get as much value and to get as engaged as possible with our journalism. That's the purpose of our audience engagement. We're not trying to simply get as many users as possible to drive clicks by anything. Everything we do we want to be congruent with our brand and what our journalism stands for.
AI: You talked about unique users. One of your competitors, the Washington Post, has made a lot of the fact that they claim they have more slightly more unique visitors per month than you do. What's your response to that?
MT: When you look at our model, we're focused. We want to be broad. It's fabulous that a newspaper, which once reached a million, two million people, essentially mainly in this city and the region, now reaches globally probably 90 million users overall a month. And we have a very big international audience as well as a domestic audience. We care most of all, however, about how many of those users we can deeply engage with our content. And crucially we don't want to do clickbait. We don't want to get to some artificial target of unique users by doing journalism or techniques which are against our brand. We want people to come to The Times for 'Timesian' journalism and 'Timesian' stories and we're very happy. We think we are successfully monetizing our audiences for news better than any other newspaper-based company in the world. We believe our digital subscription model is working brilliantly because everything that we do in the way of journalism is worth paying for. So we're very happy with our model. I'm not saying our model's right for everyone, but for us we think it's the right model.
AI: Someone backstage was saying that looking at uniques now is like two bald guys fighting over a comb. So what do you look at? Are uniques not important? Is that an irrelevant indicator?
MT: Uniques — they're the top of the funnel. They're people who are dropping in and I would say every single person first encountering Times journalism anywhere in the world. We are global. We have digital subscribers in Antarctica; this is a global enterprise. We should be doing our absolute best and it's a mixture of human judgment, editorial judgment, creativity; it's also data science. We should be doing the best we can to get that person to come in and read something else and try and develop them into a deep user. So the top of the funnel's important, but the most important thing of all is the shape of it. We don't believe in commodity news; at least that's not our model. Our model is to have deeply engaged, committed readers and then to figure out ways of monetizing.
AI: Harvard Business School, the way they teach the case on The New York Times, basically concluded that you were trying to sell people digital subscriptions but also print Sunday. That that would be the ideal subscriber. Is that right? Was that ever right?
MT: The way I think about it goes like this. We believe there's a market for high-quality journalism and that people will pay for it. We also believe the people who are prepared to spend the money, time, and attention it takes to absorb high-quality journalism are also of preferential value to advertisers. That's the core of our model. We're in a hybrid world: print and digital. Over time we expect digital to grow and grow and grow. It's a first-order issue for us to grow digital subscriptions and digital advertising together so that they more than offset the secular headwinds on the print side. Exactly how that plays out is complicated. Digital subscriptions are part of the story. Digital advertising and innovating in advertising and solving the issues of advertising in a smartphone are also an important part of what we're trying to do.
AI: So let's talk about native advertising. So you have your own studio. You've had some things that people talk about that are leaders in the field. But what have you really learned? What works? What doesn't work? Does a big studio pay for itself? Should everyone do that?
MT: It's a very good business for us. We sell media. Advertisers pay us digital advertising rates for the prominence of the content but also because advertising agencies aren't really set up for long-form multimedia storytelling of the kind we do. We also have a significant and growing production business. There was zero revenue in 2013. In 2014, year one, $13 million in revenue. This year I think over $35 million of revenue. I expect it to do $50-$60 million of revenue next year. It's just a rapidly growing business. What works is high-quality content. And I think it's a fundamental wake-up call for advertising as a whole: The idea that you can force people in a digital environment to look at poor content or to force them through an adjacency to give their attention to something that doesn't really work for them, isn't relevant — that's on the way to being over. And you need to work with advertising partners. We do this across the board at The Times. So you've got really high-quality, engaging content. And it's straightforward, that's what's working in branded content are the pieces which are great, which are enjoyable, which are valuable, and which people talk about.
AI: Are you happy with the growth of digital ad revenue? You have big goals obviously.
MT: I am. We had a hiccup in Q3 this year, but we said on our last earnings call we expect to get back to growth in the current quarter. And I believe, again, here just like on the journalism side, part of the secret is innovation. And I think that there's a lot of very bad digital advertising and very bad advertising experiences out there. We want to differentiate our advertising by impact, by creativity, by quality.
AI: So you're a survivor in some ways because you've sort of matched the lost revenue....
MT: Yes, but I want to say on the digital side, I fancy our chances much better than many digital-only publishers. I think we have the advantages of brand, of breadth, of the caliber of journalism we've got, the brand recognition outside the US. I think, in a sense, pretty much all digital publishers now also are incumbents with many of the issues of incumbency, but without some of the virtues of the impact of a gigantic brand over time. And of a really large paying core audience.
AI: So obviously The New York Times has a mission as it plays an important role in society. Does that cut you a break as CEO in terms of the time you have, the runway you have, or the returns you need to make?
MT: No. The thing that cuts you the break to a degree is the very cash-generative print business. It's obviously subject to significant and irreversible headwinds, certainly on the advertising side and arguably over time on the subscription side. But it produces a lot of cash, and currently is an extremely profitable business. That gives you some time. But there's no future for great journalism for organizations like The Times unless we can also develop successful, digitally centered, and ultimately digital-only, business models. So it doesn't solve the fundamental challenge of itself. What we need to do to secure the quality of the journalism forever is to come up with a compelling business model, which itself fundamentally depends on engaging much, much larger audiences than was historically the case with the print model.
The New York Times headquarters
Lucas Jackson/ Reuters
AI: So let's talk about platforms for a second. The New York Times is a giant in our field. It's tiny in a world with players like Facebook. New York Times content on Facebook works pretty well. It's fast, it delivers immediately to a lot of people. What's the case that you need to remain a destination, rather than using their platform?
MT: The case you need to make with individual users is about the value of an experience, which goes beyond glancing blows with individual news stories. So you've seen us over the last year or so develop things like morning briefings. Start off the day not just with two or three headlines but with something which is designed to brief you on what's happened overnight, what's the news agenda of the day, here in New York, is the mass transit system working, weather, so a basic survival kit for the day, first thing in the morning. So we are moving to offering a value of bringing things together, of tailoring content to different need states, mood states, focusing very much on optimizing our own smartphone experiences, so that we make the case for being a destination. There won't be many journalistic destinations in the smartphone future. We believe we can be one.
AI: So I asked my son, who's 22, what question I should ask. And his question was "who reads the news?" And he's very well informed; it's just he doesn't subscribe to The New York Times on any level. How do you build that number of subscribers and develop those subscribers?
MT: In practical terms, this summer we launched a new offer specifically aimed at college students. It's a very simple, significantly discounted, a dollar a week for unlimited access to The New York Times. It's converting at an astonishing rate. We're very, very interested in reaching people your son's age and convincing them if they're going to subscribe to anything, that we can offer a service, which is not just good on news but opinion, on culture, movies, theater, art and so forth. And that we can add value. And we would give him a significant free trial period to get used to the experience. And we're finding at the moment a significant number of people of that exact age group are becoming Times subscribers. And we have of course many millions of millennials and younger in our monthly uniques already.
AI: So let's go back to virtual reality for a second, you mentioned it in passing. I guess there are some people who think that is a game changer, whether it's the version you guys have or however it evolves. And some think it's a fad. What's your view? Is this a fundamental game changer?
MT: The particular thing we've been trying to prove out is that virtual reality has a role in immersing viewers, users, in real-world news stories and other great experiences. And from day one we've had commercial partners — GE and Mini launched a virtual reality film on our app the day we launched. And Google supported us by helping us give 1.3 million Google Cardboards to our customers.
What I would say is: let's see where we go. It's been already an attractive, profitable exercise for us to be involved in. I think we've shown that we can more quite quickly. The entire exercise from first idea of doing something big to 1.3 million viewers going out was five months, six months. It's partly a proof of concept to the speed with which we can move. I think one of the things the Gray Lady needs to do is pull up her skirts and start running in some areas, and this would be an example of that.
We've launched a new VR film, "Take Flight." It's stunning. I think that we don't know what can be done with VR yet. I'm a TV guy, as you know, and I think it's creative and incredibly exciting. And it may turn out to be one of those things which lasts for a period of time and then has it's niche, video games and all the rest of it. I think it's interesting. I think it's creatively interesting. And I can tell you now that in the world of branded content there's immense interest in it.
AI: In 20 years is there still a print New York Times?
MT: Definitely in 10 years in my view. Our economics are such where we're profitable seven days a week and even on really quite tough scenarios about the decline of print, we're profitable every day of the week for many years to come. Definitely a decade. I think the key thing to say is I think the print product will evolve. I think one of the things we need to do over the next few years is work out what's the right way of thinking about your print platform in a smartphone world. Already 80% of our print subscribers are authenticated using digital. By 2020 everyone will be getting most of their news principally from smartphones. How does a physical platform fit into that? We're certain that people — hundreds of thousands, and more than one million on Sunday — will want such a thing in five years time. What should it be like? How does it fit into the story?
SEE ALSO: Sony CEO Michael Lynton on surviving the 2014 hack, making money in an evolving world, and why 'The Nanny' is a hit in Russia
More: IGNITION 2015 New York Times Media mark thompson

redpajama_set_name: RedPajamaCommonCrawl


2011 February What Would Ben Franklin do?
Modern translation: Small portions and no second helpings at the dinner table pay off big time. Don't drink to get drunk.
Silence: Speak not but what may benefit others or yourself: avoid trifling conversation.
Modern translation: If you don't have anything nice to say, keep it to yourself. And avoid gossip.
Modern translation: Know when to focus on work and when to focus on play.
Modern translation: Be persistent and always follow through.
Modern translation: Manage your money wisely. As Ben Franklin once said, "Beware of little expenses. A small leak will sink a great ship."
Modern translation: Don't waste time. Be productive at everything you do.
Modern translation: Always tell the truth.
Modern translation: Treat others like you'd like them to treat you.
Modern Translation: Take everything in moderation. And if someone does you wrong, don't retaliate --- at least not as much as you'd like to.
Modern translation: Use soap, laundry detergent, trim your nose hair and pick up after yourself.
Modern translation: Don't sweat the small stuff. And don't worry about things you cannot control or change.
Chastity: Rarely use venery but for health or offspring, never to dullness, weakness, or injury of your own or another's peace or reputation.
Modern translation: At the risk of not being modern I'll quote the Book of Ecclesiastes and Pete Seeger: "To everything turn, turn, turn … a time to cast away stones, and a time to gather stones together; a time to embrace, and a time to refrain from embracing."
Modern translation: Two pretty good role models.
Franklin apparently placed each one of these virtues/values on a separate page in a small book and evaluated his performance in regard to each on a daily basis.
Although he was not entirely successful – he enjoyed his food and was quite the womanizer when he put his mind to it – his intentions were good.
Pay less attention to yourself and more attention to other people.
Criticize only when your criticism is helpful.
Never speak badly about anyone.
I'd like to invite you read an article published on AWAI's site in July of 2006. It was the first article I'd ever written for AWAI. It deals with the importance of thinking positive and setting goals. You can read it by clicking here.
I must note that like many successful writers will often tell you, looking back I've really grown as a writer. So if you're just starting out, know that wherever you are today, no matter how good or bad you think you are, you will ALWAYS be better in the future.
Of course, that's assuming that you keep writing between now and then. Because nothing will make you a better and more confident writer than practice and experience.
I've really enjoyed my time with you this week.
If there's a subject you'd like me to focus on the next time I get to contribute to The Writer's Life, please post in the comment section below.
Do you want to know my take on the issue?
Get into the rythm of a daily routine. Follow your schedule with passion.
Discipline yourself so that you are not a victim of your moods, but a creature of habit.
For example, John Grisham made it a point to wake up early in the morning.
Then, he would write one or two hours every day before departing for his office (he is a lawyer by training).
His books have become best-sellers and he is a wealthy man.
Ben Franklin's way of putting it I find rather better than yours. Any plans on doing an Iliad interpretation for us?
Bart I agree with you. Your sarcasm implies that I think that my version is better than Ben's. I was simply offering a modern translation of some pretty great words. I'm sorry you took it any other way. No plans on the Iliad interpretation by the way.
Nice article. It's good to reflect on such ideas from time to time and determine if we are being productive and being the type of person each of us would ideally like to be.


Muharrem İnce looks on in the background as CHP leader Kemal Kılıçdaroğlu speaks at a party congress ahead of the June 24 elections.
COLUMNS What are the US and Russia cooking up in Syria?
The opposition alliance, heralded by the Western media as a viable force to defeat President Recep Tayyip Erdoğan in the June 24 elections, lies in complete disarray. The nationalist Good Party (İP), a key partner of the alliance, has already announced that the group has collapsed.
With President Erdoğan receiving 52.5 percent of the votes in the presidential election, and the People's Alliance between the Justice and Development Party (AK Party) and the conservative Nationalist Movement Party (MHP) winning a majority in Parliament, the opposition alliance simply became redundant and worthless.
This also proved that they had only come together to "stop" Erdoğan and had no real plans or projects for the nation if by any chance they won the polls. They were simply paper tigers, fooling the masses.
Some so-called Turkish commentators and "experts" who wrote fiery articles in prominent Western newspapers claiming that Erdoğan's days were numbered and that Muharrem İnce was slated to win the presidential elections only proved that they are highly biased, misinformed, unreliable and are poorly qualified to make sensible evaluations about the Turkish political climate.The election results did not only lead to the collapse of the unholy opposition Nation Alliance, formed by the left-wing Republican People's Party (CHP), the Felicity Party (SP), the tiny Democrat Party (DP) and the İP. Now, these parties are also facing some serious internal problems.
The CHP not only lost the presidential race – despite the relatively strong showing of Muharrem İnce with 31 percent of the votes that easily surpassed CHP's 22.5 percent in the parliamentary polls – it also could not win a majority with the alliance. Party leader Kemal Kılıçdaroğlu is now regarded as a great failure and there are popular demands to replace him with İnce. However, Kılıçdaroğlu rejects calls for his resignation. İnce and his supporters will apparently try to force a party convention to topple Kılıçdaroğlu.The so-called main opposition party is not only divided but is shifting aimlessly on a rocky terrain. This is the same party that would have ruled Turkey if it was successful in the June 24 elections. They are not even equipped to shoulder the role of the main opposition.
Then, of course, there is the Meral Akşener's İP. In the initial stages of the election campaign, she was billed as a great hope against Erdoğan but as time went by and İnce became the CHP's presidential candidate, she lost her standing with the electorate and was eventually a dismal failure in the presidential race. Her party managed to get into the Parliament despite failing to pass the 10 percent threshold, simply because the party was part of the Nation Alliance.
Temel Karamollaoğlu who chairs the SP was also a great loser, having no impact in either the presidential or the parliamentary elections.
The state of these parties and the state of their presidential candidates clearly shows that Turkey had a lucky escape on June 24. Sadly, supporters of the opposition alliance completely fooled some foreign states and the Western media with false expectations. Let us just hope that they have learnt a lesson and will not be fooled again by some "Turkey experts and columnists."


text:
Press Releases Brintons Secure Delhi Airport Contract
Brintons Secure Delhi Airport Contract
Brintons, a world leader in the design and manufacture of woven Axminster carpet for more than two centuries, has been awarded the contract to supply all of the carpet (totalling the area of 24 football pitches) to the brand-new Terminal 3 building that is being constructed at Indira Gandhi International Airport in Delhi, India.
Brintons has a long and distinguished history as a trusted supplier of quality Axminster carpet to lots of airports around the world and it's most recent work has been at Singapore's spectacular Changi Airport.
The company's proven reputation for developing stunning original designs, manufacturing carpet of unrivalled quality and its exemplary project management skills were central to Brintons being awarded the Delhi contract.
The Terminal 3 structure will be completed in time for the 2010 Commonwealth Games and will be the third biggest airport terminal building in the world. Brintons will be required to manufacture and supply 175,000m² of woven Axminster – the area of 24 football
pitches – for different floor spaces within the state-of-the-art terminal.
To meet the interior design brief, Brintons' design teams in Singapore and India have carefully developed carpet designs that illustrate Delhi's rich historical past and its vibrant and modern present.
In order to capture the mood and spirit of the theme, Brintons has fused the design elements from Delhi's magnificent historical monuments with the modern and sophisticated skyline of the city to create a contrasting, yet harmonious image of the old and the New Delhi. And with patterns being an essential part of Indian design, Brintons has incorporated geometrics, swirls, floral and foliage, as well as the most famous Indian shape, the Paisley, into its carpet designs for Terminal 3.
And as you would expect from a carpet that illustrates Indian culture and history, Brintons has used a plethora of rich colours in its designs. These have been picked from typical street scenes, monuments, foods, spices and festivals in all four regions of India.
Brintons' global sales and marketing director, Jon Stone, said: "We're thrilled that we have been chosen as the exclusive supplier to Delhi Terminal 3 and we're very excited about getting down to work and delivering what I think will be one of the most visually stunning carpets that has ever been installed in an airport.
"The designs and colours are really vibrant and invigorating and I think Delhi will set a new benchmark for having a carpet that is both businesslike – something you expect to see in an airport – but also very culturally stimulating and energetic."
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Surplus glycerol from biodiesel production can be transformed to valuable fuel additives through etherification with isobutene. Our previous work has studied the kinetics and thermodynamics of this reaction. In the present work, a novel process design is proposed. An optimization problem is also formulated to minimize the cost of production of the di-tert-butyl ethers and tri-tert-butyl ether of glycerol. The resulting mixed-integer nonlinear program enables simultaneous determination of values of key decision variables including number of column trays, feed tray location of column, volume of reactor, process flowrates etc. The optimal design leads to a minimal production cost of glycerol ethers of 1.201 $/kg, which is dominated by the cost of isobutene.


I was looking for inspiration one morning, and was actually seeking a big bloomed flower to recreate. But Spring is a time of small unfolding, with petite, delicate blooms leading the way and soft discrete colours. I was instantly drawn to a pot of Minnow Narcissus', their buttery soft yellow petals and large open trumpet throats. And sitting right next too them were hundreds of heads of Primulas. The two made the most perfect pairing, and I knew then that this was all the inspiration I needed.
These are so simple to make, but look absolutely gorgeous on all sorts of cakes, Mini Cakes, Cupcakes, Fondant Fancies........the choices are endless.
Lightly TREX your non stick board and thinly roll out your Florist paste to approximately 1 mm thick.
Using your daffodil cutter, cut out 2 shapes per flower. Make sure to rub your finger around the edge of the cutter to take off any 'furry' edges so that you achieve a clean cut. Ensure that you don't allow the shapes or paste to dry out by covering them with a plastic sheet or food bag.
On a celpad roll the veining / frilling tool across each of the petals.
Flip the cut shape over and using the thinner side of Dresden tool, run it with firm pressure from the tip of the petal to the edge of the centre. Pinch the tips of the petals to achieve a pointed edge.
Upturn the petals back to the right side up. Place a small amount of glue into the centre of one of the petals and place the second petal directly on top of it, with the underneath petals sitting between the gaps. Gently shape by pressing in the centre with a Ball or Bone tool.
For the 'Throat', take a tiny piece of paste (watch out - it is natural to start with too big a piece!) and roll the paste into a small ball. Make sure that it doesn't have any cracks in it, if it is a little dry you can rub in a tiny amount of vegetable fat. Using the Veining tool, indent a slight hole into the centre, then roll the two together on the celpad to enlarge the hole to create the veined throat.
Attach this with edible glue to the body of the flower, again securing to together with a Ball or Bone tool. Place the flowers in dimpled foam, scrunched up foil or tissue to dry in shape.
As an option you could dust the throats with a little yellow edible dust.
Pipe 3 small dots with the Royal icing to finish.
Brown food colouring & vodka, lemon juice or another clear alcohol.
On a lightly greased board roll your pale yellow paste thinly into a mexican hat. You are looking to get the paste about a millimetre thick around the edge.
Using the primrose cutter, place the rolled paste onto a non-stick board and cut out the shape with the 'hat' in the centre.
Using the edge of the celpad (or if you find easier place the upturned shape into the holes in a celpad) and stretch and soften the edges with the edge of a Bone tool. You are looking to achieve an effect where the leaves will slightly overlap each other. But be careful not to overwork too much so that you distort the petals too much.
Use the cone tool to indent into the centre to shape. Allow to dry in dimpled foam or tissue.
When dry you can dust the flowers. On some tissue work a little edible dust into a brush and gently dust the centres of the flowers.
If you wish you can paint the petals with some brown paint, let down with a little clear alcohol or lemon juice.
To make the leaves, roll the green paste to approximately 1 mm thick, cut with the leave cutter and emboss with a silicone leaf mould. Leave to set in shape in dimpled foam, foil or tissue.


Having a baby during the busiest time of the year is never a bad idea!
Having a baby in December can be pretty chaotic. While everyone is shopping for gifts, decorating trees, and being invited to parties left and right, here you are waiting for a human being to pop out of you. In the US, this month is actually the rarest time for birthdays, with December 24 and 25 being the rarest of all, since inductions and C-sections are less likely to be scheduled on the holidays.
Growing up, babies born in this month may have to cope with the holidays overshadowing their future birthdays, but they should not feel too bad — according to research and studies, December babies are pretty lucky (and their parents, too!).
Babies born in December have the best chance of living up to a hundred years old.
A 2011 study compared the birth months of 1,574 people who lived past 100 to 10,885 shorter-lived siblings and 1,083 spouses. Researchers found that December-born individuals were more likely to live up to age 105 compared to those who were born in June. So, while December babies are rare, they'll also be around for a long, long time.
December babies have lower risks for cardiovascular disease.
If your babies are living up to a hundred or more, it may be because they also have a lower risk for cardiovascular disease, according to a 2015 study. Researchers from the Columbia University Department of Medicine examined 1.75 million patients born between 1900 and 2000 who had been treated at the university hospital and found that those born from September through December were more protected from cardiovascular diseases.
Babies born in December fall asleep earlier.
Can your birth month actually dictate whether you'd be a morning or evening person? A 2009 study of Italian and Spanish university students found that those born in December tend to fall asleep earlier, while a similar study noted that students born in the same month were more likely to become morning people than those who were born in June. New parents may take these studies with a grain of salt, but look on the bright side — your babies may give you an easier time when it comes to sleep training!
December-born boys are more likely to be left-handed.
A study of 13,00 adults by the University of Vienna found that 7.5% of women and 8.8% of men were left-handed. Researchers looked at male birthdates and found that most of the left-handed men were born between November 1 and January 1.
If your baby's dominant hand is his left, you should know by now not to try and correct it. Child development researchers believe that forcing a left-handed child to be right-handed could affect how your child's brain is wired, and thus, pushing it to work harder. He may have more difficulty writing, using scissors or knives, and may not perform well or may get more tired easily when doing activities such as sports.
Besides, being left-handed may be a good thing! "When we're left-handed, our right brains are usually dominant, and that's where creativity and intuition are centered. So, it's often easier for us to be creative than logical. And our brains more easily use both sides of the brain at once, so we have the advantage of also being more flexible in our thinking," explains child educational psychologist and author Charlotte Reznick, Ph.D., in an interview with Fast Company.
December babies can be creative, intelligent, and hardworking.
If you're a big believer of astrological signs, then you'd be happy to know that babies born in December have some pretty awesome key traits. Those born between November 22 and December 21 fall under Sagittarius, who are known to be adventurous, creative, and strong-willed. Those born between December 2 and January 19 are Capricorns, known to be detail-oriented, intelligent, and hardworking.
December babies are also less irritable.
Do you think the month in which you were born can have an influence on your mood? A 2014 study seems to thinks so. Xenia Gonda, an associate professor at Semmelweis University in Budapest, Hungary, surveyed 366 students to determine which of "four kinds of temperaments they most personify." Questions like "My mood often changes for no reason" and "I love to tackle new projects, even if risky," and "I complain a lot." She then correlated their answers with their birthdays.
Those born in the winter (December to February) were significantly less prone to irritable temperament and had fewer mood swings compared to those born in the summer (June to August).
December babies are most likely to become a dentist.
Over in the United Kingdom, December-born babies are the most likely to grow up to work as dentists, according to a census analysis done in the country, as reported by The Guardian. There's no way of knowing whether it will hold true in the Philippines, but the possibility of raising a future dentist isn't so bad, right? You'll get loads of discount on dental care, that's for sure!


text:
Phil McNamara
Writer for the environment
Seal Bay, Kangaroo Island, SA – groundcover
About Phil McNamara
Phil lives with his wife and daughter in the Adelaide Hills, South Australia, and has a bush block near Seal Bay on Kangaroo Island. As a young adult, he loved to read Charles Darwin books, which fostered a strong interest in writing about our relationship with nature.
Red Reflection is Phil's first novel (coming soon). He has started working on the sequel, which he hopes to complete in 2021. Phil is also a blogger and writes short stories and poetry.
Phil rides a motorbike to and from work to reduce his carbon footprint and chairs his work's Carbon Action Committee, which encourages staff to take action on climate change.
At home, Phil tries to live a sustainable life with solar electricity and water, and has an insect friendly garden. Phil is also a trail runner and plogger (a new trend from Sweden where joggers pick up rubbish along the way for the sake of the environment).


When Hurricane Maria destroyed the power grid for 80 percent of Puerto Rican citizens, the tiny island of more than three million people was cast into darkness. For many, the lack of a reliable power backup cost them their lives.
Energy insecurity and power outages can often result in the same thing – loss of life. That's why intelligent energy management systems could become the future of the electrical grid, particularly with the increasing prevalence of climate change-related severe weather events. Incorporating sustainable energy solutions into home planning is an increasingly vital decision for homebuyers.
For Puerto Ricans, solutions were scarce as the island awoke to the realization that all of their major infrastructure had been wiped out in hours. One energy management company, sonnen, knew they could help. Their smart energy management systems are designed to work with traditional power sources and solar energy to keep the essentials running, even in the event of mass grid failure.
Basic necessities like clean water and safely stored food are pivotal in an emergency situation. Ensuring that you have enough power to maintain those resources can be a challenge. Intelligent energy management systems, like the new sonnen ecoLinx with energy automation, create a clear interface between the user and their available power. These systems allow the user to know how much power they have, what it can run, and for how long. The user can choose where their energy will be utilized during a grid outage, ensuring they are able to power the devices that are most essential for survival.
All these components communicate with each other to create a safety net, monitoring variables in real-time to prevent homeowners from being caught unaware. Home automation control interfaces like Crestron and Control4 can be seamlessly integrated with sonnen's energy automation software to create an intuitive interface which the user can operate from their smartphone or from a wall-mounted digital display.
Whole-home communication allows the entire system to work in unison to create an optimal experience for the user. For example, the ecoLinx's smart weather management system links to the National Oceanic and Atmospheric Administration (NOAA) weather database forecasting system to predict inclement weather. It then alerts the homeowner and asks if it should increase the amount of stored power in the battery in case of an outage.
Mapel offered this example: "Customers who are in hurricane zones may keep a higher backup buffer; 50-80 percent of the battery may be reserved for a backup situation." She continued, "If a hurricane is anticipated, there's a likelihood that your power will go out and you're not sure for how long. You might tell your system, 'I just want to power the basics,' and the home automation system is set up by the installer to know what is covered under 'the basics.' Then the home would shut down all the non-essential loads and utilize the batteries and solar system to just power the essentials." When the storm has passed and the grid regains power, the management software would automatically restore the house to regular service.
Systems like the ecoLinx can also be employed during a power "brownout," in which the electrical power supply system is disrupted for a short time. In these situations, the system can be set to power the whole house during the duration of the outage. Laptops, lights, refrigerators, stereos, and HVAC can all be powered by the battery system. As long as the user is confident the outage is temporary, they could comfortably use all of their battery reserves to keep the house operating with full power.
Enhancing the resiliency of the grid will become increasingly important as climate change becomes a more pressing global concern. That's why sonnen is working with home developers, such as Mandalay Homes in Arizona, to create connected communities.
According to Mapel, these communities utilize combined intelligent energy storage and solar generation to create clean energy virtual power plants. The community's needs balance with each other, with some houses using less power, or creating more power, which can then be used as a surplus by the community. Clean energy communities, like Mandalay Homes' Jasper community, benefit homeowners as well as the utility companies, enabling the grid of the future.
Ultimately, intelligent energy management systems like sonnen's ecoLinx could change the face of residential energy management, creating more resilient, more sustainable, and safer power options for communities across the globe.


Long time Washington insiders Norman Ornstein and Thomas Mann join us to discuss why they believe that Washington is not working for the American people and who is responsible. Ornstein, a senior fellow at the American Enterprise Institute, writes a weekly column for Roll Call called Congress Inside Out and is an election eve analyst for CBS News. Congressional scholar Thomas Mann is a senior fellow in governance studies at the Brookings Institution. Both are authors of the best-seller It's Even Worse Than It Looks: How the American Constitutional System Collided with the New Politics of Extremism.
Come early and watch the debate on CNN!
You don't have to choose! The Presidential Debate will be screened in the Billy Wilder Theater from 6:00-7:30PM, just prior to this program.


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Music consumption (in terms of album sales, digital tracks and streaming volume) is up, thanks in large part to increases in streaming. So can market-level streaming activity help radio programmers when it comes to their format?
In September, we announced that we're expanding the use of our Portable People Meter™ (PPM) technology for local TV ratings. In anticipation of this update, local TV stations require up-to-date encoding hardware in place to enable TV measurement through the PPM technology.


text:
Learning leadership
Kyanne Derr was finalist for Distinguished Student Award
Kyanne Derr, a junior at Glenburn High School, was a state finalist for the North Dakota Activities Association/Farmers Union Insurance Distinguished Student Award. Submitted Photo
Glenburn High School junior Kyanne Derr is a girl on the go and that is just the way she likes it.
"There's not a lot of down time," said Derr, who was one of six state finalists for the North Dakota High School Activities Association/Farmers Union Insurance Distinguished Student Award this month.
The award honors students who are the "backbone" of interscholastic activities, not necessarily the leader of them. Student recipients strengthen the activity for other participants, their school and their community.
Derr plays club volleyball and serves as the team captain and also plays softball. She is a member of the Glenburn school council and serves on the school's suicide prevention group, Sources of Strength, which puts an emphasis on sources of positivity in the lives of students as a way to help them.
Music is a huge passion for Derr, who hopes to major in music education when she goes away to college and who would like to be a music teacher.
""I am in choir but my main focus is instrumental," she said. "I play the saxophone. I started on tenor (saxophone) but play a lot of soprano (saxophone) now."
She participates in honor bands and music festivals and plans to attend a couple of music camps this summer, one at Minot State and one at the International Music Camp, which she has attended since the summer after she was in fifth grade.
Serving as a team captain has also helped her in other areas, she said, particularly leadership.
"I think being involved in so many things has helped me get to know how to work better with different people," said Derr.
Her parents, Larry and Donanne Derr, both of whom are employed at the school and coach, have led by example. Her dad is the high school principal and high school activities director and head boys basketball coach for Glenburn. Her mom teaches third grade for Glenburn. Her parents always encouraged her to be involved in different activities.
"I was in the gym almost as much as I was home, I think," said Derr, who is the eldest of four children.
Attending a small school also meant there were always opportunities to be involved in a lot of different activities.
Other finalists for the award were Sophie Lind, Mandan, Alexis Roehl, Grand Forks Central and Keaton Nelsen, Leeds. Michael Hall, a junior at Kindred High School, was the winner of the award and Annah Greenmyer, North Sargent, was the runner up.
Other nominees from area schools were Payton Heger, Underwood, Brenden Bergquist, Turtle Lake-Mercer, Payton Smith, Carrington, Theodore Allmaras, New Rockford-Sheyenne, Gavin Miller, North Star at Cando, Emily Eback, Devils Lake, Shadlynn Severance, Parshall, Corina Pabian, Lewis and Clark-Berthold, Abigail Hickel, Ray, Trent Hunskor, Newburg, Emma Arstein, Rolette, London Andel, Bottineau, Caitlyn Davis, Dunseith, Maria Blessum, Rugby, Kyley Lauf, Des Lacs-Burlington, and Mindee Boyce, Nedrose.
(Prairie Profile is a weekly feature profiling interesting people in our region. We welcome suggestions from our readers. Call Editor Mike Sasser at 857-1959 or Regional Editor Eloise Ogden at 857-1944. Either can be reached at 1-800-735-3229. You also can send e-mail suggestions to msasser@minotdailynews.com.)
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text:
Кабазитаксел (, ) — напівсинтетичний лікарський препарат, який за своїм хімічним складом є дериватом іншого лікарського засобу — доцетакселу, що належить  до групи таксанів. Кабазитаксел застосовується виключно внутрішньовенно. Кабазитаксел розроблений у лабораторії компанії «Sanofi-Aventis», та схвалений для використання у клінічній практиці FDA 17 червня 2010 року, та 21 січня 2011 року Європейським агентством з лікарських засобів.

Фармакологічні властивості
Кабазитаксел — напівсинтетичний лікарський засіб, який належить до групи таксанів. Механізм дії препарату полягає у зв'язуванні препарату із бета-тубуліном мікротрубочок цитоплазми, що призводить до порушення процесу його деполімеризації, наслідком чого є порушення процесів динамічної реорганізації сітки мікротрубочок, що порушує функціонування внутрішньоклітинних структур, а також порушує процес мітозу. Оскільки мітотична активність більш виражена у клітин, які швидко ростуть, то кабазитаксел більш активний до клітин злоякісних пухлин. Кабазитаксел має здатність інгібувати нечутливість пухлинних клітин до препаратів групи таксанів (доцетакселу і паклітакселу) завдяки додатковій метильній групі, яка знижує афінність білка, що сприяє виведенню таксанів із пухлинних клітин. Кабазитаксел також краще проникає через гематоенцефалічний бар'єр, завдяки чому він може діяти на метастази пухлини в головний та спинний мозок. Натепер кабазитаксел застосовується у складі комбінованої терапії при раку простати (разом із преднізоном і преднізолоном), у тому числі у випадках пухлин, резистентних до доцетаксела. Хоча кабазитаксел є значно ефективнішим препаратом, особливо у випадку резистентності пухлини до інших хіміотерапевтичних засобів, при його застосуванні спостерігається більше побічних ефектів, зокрема частіше в порівнянні з мітоксантроном спостерігається виражена нейтропенія, а також анемії та діареї в порівнянні з абіратероном.

Фармакокінетика
Кабазитаксел після внутрішньовенного введення швидко розподіляється в організмі, максимальна концентрація препарату в крові досягається до закінчення інфузії кабазитаксела. Препарат створює високі концентрації у більшості тканин та органів. Кабазитаксел добре (близько 90 %) зв'язується з білками плазми крові. Препарат проникає через гематоенцефалічний бар'єр, через плацентарний бар'єр, та виділяється в грудне молоко. Препарат метаболізується у печінці із утворенням як активних, так і неактивних метаболітів. Виводиться препарат із організму переважно з калом, незначна кількість виводиться із сечею, переважно у вигляді метаболітів. Період напіввиведення препарату становить 95 годин, при порушенні функції печінки час напіввиведення препарату може збільшуватися.

Покази до застосування

Кабазитаксел застосовується для лікування гормонорезистентного раку простати при неефективності доцетаксела в комбінації з преднізоном або преднізолоном.

Побічна дія
При застосуванні кабазитаксела побічні ефекти спостерігаються досить часто, найчастіше спостерігаються нейтропенія, діарея, загальна слабість, швидка втомлюваність. Іншими побічними ефектами доцетаксела є:
 Алергічні реакції та з боку шкірних покривів — шкірний висип, свербіж шкіри, сухість шкіри, алопеція, еритема шкіри, гарячка, важкі шкірні алергічні реакції.
 З боку травної системи — нудота, блювання, запор, біль у животі, сухість у роті, геморой, кровотечі з прямої кишки, гастроезофагеальна рефлюксна хвороба, здуття живота.
 З боку нервової системи та опорно-рухового апарату — головний біль, запаморочення, парестезії, гіперестезії, летаргія, периферична нейропатія, кон'юнктивіт, шум у вухах, неспокій, сплутаність свідомості, спазми у м'язах, артралгії та міалгії, біль у спині, біль у кінцівках, м'язовий біль у грудях.
 З боку серцево-судинної системи — артеріальна гіпотензія, артеріальна гіпертензія, тромбоз вен, припливи крові, тахікардія, миготлива аритмія.
 З боку дихальної системи — задишка, кашель, пневмонія, біль у ротоглотці.
 З боку сечостатевої системи — ниркова недостатність (у тому числі гостра), гематурія, болючий сечопуск, затримка сечопуску, нетримання сечі, гідронефроз, ниркова колька, біль у тазовій ділянці.
 Інфекційні ускладнення — сепсис, септичний шок, целюліт, грип, інфекції сечовидільних шляхів, інфекції верхніх дихальних шляхів, кандидоз, оперізуючий герпес.
 Зміни в лабораторних аналізах — анемія, тромбоцитопенія, лейкопенія, підвищення рівня білірубіну в крові, підвищення активності амінотрансфераз в крові.

Протипокази
Кабазитаксел протипоказаний при підвищеній чутливості до препарату, при вираженій нейтропенії, виражених порушеннях функції печінки, вагітності та годуванні грудьми, у віці до 18 років, при одночасному щепленні вакциною проти жовтої гарячки.

Форми випуску
Кабазитаксел випускається у вигляді концентрату для приготування розчину для внутрішньовенних інфузій у флаконах по 1,5 мл із вмістом діючої речовини 40 мг/мл.

Примітки

Посилання
 Кабазитаксел на сайті mozdocs.kiev.ua
 https://www.rlsnet.ru/tn_index_id_50631.htm

Лікарські засоби за алфавітом
Таксани


The forgot password function in Light, Business and Websocket is not working when used with other than the english language.
That bug has been fixed and will be included within the next release.
That will fix the issue. Included in the next release.


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The main aim of the measure was to set up new parking schemes, adjust pricing, install adequate signposting for off-street parking and develop new areas for the parking of heavy goods vehicles.
Prior to measure implementation, parking in Burgos was particularly problematic. Parking was disorganised and unregulated, with large trucks parking in the city centre and private motorists frequently infringing parking regulations by double or even triple parking, thus hindering traffic flow and aggravating congestion. Off-street parking was not used due to inadequate signposting and relatively high charges, and street parking was free.
The measure was therefore aimed at setting up a new zoned parking scheme with prices adjusted according to parking time and concessions for residents; preventing bad parking via increased controls and fines; and establishing new parking areas for goods vehicles, which previously had little alternative but to park in the city centre under flyovers or along main roads.
The development of regulatory norms for surface parking was the first step in the parking strategy. This activity involved moderating the political debate with all stakeholders and, having achieved a degree of consensus, to develop and test the technological systems for parking management, the provision of information and improvements to service quality. Special categories of parking (such as tourist parking and high occupancy systems) were analysed in order to identify the most appropriate model. In addition, a technical project to increase parking capacity for heavy goods vehicles was developed, which would also monitor the movements of such vehicles at a traffic control centre. Another important aspect was the design of an integral concept of parking and intermodality, allowing fluid passenger movement between different modes of transport.
How did the measure progress?
A parking plan for heavy goods vehicles was developed and implemented.
Tariffs for off-street parking were changed to a time-based system.
Information panels indicating traffic conditions and the availability of free off-street parking have saved time for drivers and helped prevent pollution.
Parking capacity was reorganised and expanded to meet the demand of residents and visitors.
What were the outcomes of the measure?
More than 30 percent increase in the rate of occupancy of off-street parking.
Illegal parking fell from 200 cases per day to less than 20 in the main streets of the city, helped by the efficiency of the "multa-car", which gave first warnings to more than 100 cars per day: as a result, 90 percent of drivers did not require a second warning.
Information panels were well received by drivers, tourists and citizens, saving many useless trips and fuel. Since they were installed, they have provided guidance for more than 4,000 cars, saving more than 1 km in the case of each car trying to find a free parking space.
This website is produced as part of CIVITAS SATELLITE, a coordination and support action funded through the EC's Horizon 2020 programme under grant agreement no. 713813.
© Copyright 2013 CIVITAS Initiative. All rights reserved.


text:
Fluorescence, nucleic acid strands help show computing operations inside a living cell
Strands of nucleic acid and a fluorescence reporter helped to demonstrate basic computing operations inside a living mammalian cell.
Lee Dubay
Using strands of nucleic acid and a fluorescence reporter, scientists at the Georgia Institute of Technology (Georgia Tech; Atlanta, GA) and colleagues have demonstrated basic computing operations inside a living mammalian cell. The research could lead to an artificial sensing system that could control a cell's behavior in response to such stimuli as the presence of toxins or the development of cancer.
Related: Non-damaging, light-emitting nanoprobes enable long-term study of living cells
The research uses DNA strand displacement, a technology that has been widely used outside of cells for the design of molecular circuits, motors, and sensors. Researchers modified the process to provide both "AND" and "OR" logic gates able to operate inside the living cells and interact with native messenger RNA (mRNA).
The tools they developed could provide a foundation for biocomputers able to sense, analyze, and modulate molecular information at the cellular level. Philip Santangelo, an associate professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, says the devices could sense an aberrant RNA, for instance, and then shut down cellular translation or induce cell death.
Using strands of nucleic acid, scientists have demonstrated basic computing operations inside a living mammalian cell. Shown examining a cellular "AND" gate are associate professor Philip Santangelo and research scientist Chiara Zurla. (Credit: Rob Felt, Georgia Tech)
Strand displacement reactions are the biological equivalent of the switches or gates that form the foundation for silicon-based computing. They can be programmed to turn on or off in response to an external stimuli such as a molecule. An "AND" gate, for example, would switch when both conditions were met, while an "OR" gate would switch when either condition was met.
In the switches the researchers used, a fluorescence reporter molecule and its complementary quenching molecule were placed side-by-side to create an "off" mode. Binding of RNA in one of the strands then displaced a portion of nucleic acid, separating the molecules and allowing generation of a signal that created an "on" mode. Two "on" modes on adjacent nucleic acid strands created an "AND" gate.
Image shows activation of "AND" gates in cells as observed by fluorescence microscopy. (Credit: Chiara Zurla, Georgia Tech)
Georg Seelig, assistant professor of computer science and engineering and electrical engineering at the University of Washington, says that in the longer term, the research team wants to expand this technology to create circuits with many inputs, such as those they have constructed in cell-free settings.
The researchers used ligands designed to bind to specific portions of the nucleic acid strands, which can be created as desired and produced by commercial suppliers.
Challenges in the research team's work were getting the devices into the cells without triggering the switches, providing operation rapid enough to be useful and not killing the human cell lines that the researchers used in the lab.
The nucleic acid computers ultimately operated as desired, and the next step is to use their switching to trigger the production of signaling chemicals that would prompt the desired reaction from the cells. Cellular activity is normally controlled by the production of proteins, so the nucleic acid switches will have to be given the ability to produce enough signaling molecules to induce a change.
Cells, of course, already know how to sense toxic molecules and the development malignant tendencies, and to then take action. But those safeguards can be turned off by viruses or cancer cells that know how to circumvent natural cellular processes.
Full details of the work appear in the journal Nature Nanotechnology; for more information, please visit http://dx.doi.org/10.1038/nnano.2015.278.
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text:
Extract from "The diary of a doctor's wife" by by Winifred Heberden
This interesting diary of the Siege of Kimberley covers the period 16th October 1899 to 21st February 1900. At the outbreak of the war, Winifred's husband, Dr. G.A. Heberden, (affectionately known as 'Jack' to his family and friends), was the District Surgeon of Barkly West; and when it was realized that the Anglo-Boer War was inevitable Dr. Heberden decided to offer his services to the Imperial Forces in Kimberley, and that night he tied his three year old son, Reggie, to his back with a blanket and, together with his wife and 19 year old cousin, Harry Gibbs, left everything they possessed behind and rode on horseback the 23 miles into Kimberley. Dr. Heberden was enlisted as Surgeon Captain under Imperial Orders. (The diary is available online in two parts: Part One and Part Two.)
Significant Events Elsewhere
On 11 March 1871 the Dutoitspan farm was sold to Lilienfeld, Webb and partners (the London and South African Exploration Company) for £2600. The diamond controversy that followed and the Keate Award verdict of 1871 led to the annexation of the farms from the Orange Free State which became part of Griqualand West, which in turn was absorbed into the Cape Colony.
0n March 11th 1978 Robert Sobukwe was buried in Graaff Reinett. Sobukwe was an impressive personality who had considerable political influence on South African politics. His philosophy of Black Awareness was one of, if not the, major source of inspiration for the Black Consciousness Movement of Steve Biko. Sobukwe had met Biko when attending his mother's funeral in Umtata.
Robert Sobukwe, from a speech in 1959:
"I wish to state that the Africanists do not at all subscribe to the fashionable doctrine of South African exceptionalism. Our contention is that South Africa is an integral part of the indivisible whole that is Africa. She cannot solve her problems in isolation from and with utter disregard of the rest of the continent. It is precisely for that reason that we reject both apartheid and so-called multi-racialism as solutions of our socio-economic problems.
Apart from the number of reasons and arguments that can be advanced against apartheid, we take our stand on the principle that Africa is one and desires to be one and nobody, I repeat, nobody has the right to balkanise our land.
Against multi-racialism we have this objection, that the history of South Africa has fostered group prejudices and antagonisms, and if we have to maintain the same group exclusiveness, parading under the term of multi-racialism, we shall be transporting to the new Africa these very antagonisms and conflicts. Further, multi-racialism is in fact a pandering to European bigotry and arrogance. It is a method of safeguarding white interests, implying as it does, proportional representation irrespective of population figures. In that sense it is a complete negation of democracy.
To us the term "multi-racialism" implies that there are such basic insuperable differences between the various national groups here that the best course is to keep them permanently distinctive in a kind of democratic apartheid. That to us is racialism multiplied, which probably is what the term truly connotes. We aim, politically, at government of the Africans by the Africans, for the Africans, with everybody who owes his only loyalty to Africa and who is prepared to accept the democratic rule of an African majority being regarded as an African."
Primary information source courtesy of Kimberley Calls...and Recalls Facebook Group


Dental crowns are a means of protection for a tooth that is weakened by decay. Most often, dental crowns are applied to molars that have had extensive work done. This is because left the way it is, dental fillings can weaken a tooth to the point where it will crack and break. Dental crowns cap the tooth and make them stronger so that they are able to be used for chewing. Dental crowns can also be applied to teeth that are severely ground down due to teeth grinding, a common malady that impacts many people.
As with other dental appliances, there are a variety of materials that can be used for the crown, including porcelain, metal, ceramic, resin, and stainless steel. Each material comes with its own pros and cons, which need to be discussed with your dentist prior to creating the crown.
One of the first things your dentist is going to do if a crown is the best course of treatment is to check on the overall health of the tooth. If you have had extensive decay or work done on the tooth, a root canal may be necessary. Your dentist may suggest doing the root canal himself or sending you to an endodontist, a specialist that works primarily with root canals. If the tooth is a back molar, he will most likely send you to an endodontist due to the many canals in those teeth.
Once any root canal work is done, if it is needed, you will then return to your dentist's office to create the crown. This normally takes two appointments to complete. The first appointment involves shaping the tooth to prepare it for the crown. The tooth usually needs to be ground down until it is a specific thickness and shape.
When the tooth is prepared, the dentist will then take impressions of the tooth. The impression is important because it is sent to the lab in order for the crown to be made. You want the crown to fit in your mouth perfectly, so a good impression is critical to success. While your crown is being made in the laboratory, which normally takes two weeks, you dentist will likely place a temporary crown. This temporary crown will help protect your tooth until the permanent crown is placed. Treat the temporary with caution and do not bite down on hard things.
At the second appointment, the dentist will remove your temporary crown. He/She will then place the permanent crown on your tooth to check the fit, bite, and appearance of the tooth. If the crown is in a location where it is visible when you smile, the dentist will likely have you check the appearance for yourself. This is not the time to be shy! Once the permanent crown is affixed to your teeth changes cannot be made, so be sure the color and appearance is what you want, even if it means having to replace the temporary crown until your new one can be fixed. If everything is good, the dentist will cement the crown to your tooth.
Lastly, your dentist will give you instructions on how to care for your crown and any restrictions for the next couple of days while it cures. Your crown should last you 5-15 years depending on wear.
Dental crowns can be costly, especially when paired with root canal work beforehand, but, overall, the main goal is to retain as much original tooth as possible for as long as possible. Even having to be replaced every 5-15 years, dental crowns are still the preferred treatment to save the tooth instead of pulling it or replacing it with an implant.


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If you're not sure if your insurance will cover the cost of speech therapy, talk to your employer's human resources representative. If you're uninsured or underinsured, contact the appropriate department in your state for information on insurance programs.
Ask your employer if he offers a flexible spending account (FSA). An FSA allows you to designate a portion of your income for qualifying medical and childcare expenses. The income is not subject to payroll taxes, which can save you a nice chunk of change.
Talk to several speech-language pathologists (SLP) in your area and compare their rates. Speech Buddies Connect is an easy way to message a lot of local and virtual therapists, fast. You can also contact local universities and colleges in your area and ask them if they have speech therapy clinics. At a university-sponsored speech therapy clinic, your child can often receive treatment at a reduced rate by graduate students who are supervised by SLPs.
Even if your child does qualify for free speech therapy sessions under early intervention or special education programs, he might need extra help. If your Individualized Education Program (IEP) team refuses to add more speech therapy sessions to his weekly schedule and filing a complaint gets you nowhere, consider combining public and private speech therapy. You won't have to pay the full burden, and your child will get the help he needs.
Many hospitals, clinics, and early childhood centers offer services based on a sliding scale. It's always worth asking your child's speech therapist if she offers a reduced fee or sliding scale program based on your income.
Join a support group for parents of speech disordered children. If you can't find one in your area, create one. Network with other local parents and gauge the interest for a support group. Ask the other parents if they might consider hiring a speech therapist to do group sessions for all of the youngsters. The SLP will almost certainly increase her speech therapy rates for group sessions, but the cost will still be lessened when split amongst a group.


text:
Dirk McDermott
Sean Ebert
J.P. Bauman
Purcell Allen
Realized Investments
ThoughtTrace Raises $10 Million from a Syndicate of Investors to Advance its AI-driven Document Intelligence and Contract Analytics Software
ThoughtTrace, Inc.
The Financing Round was Led by McRock Capital, with Chevron Technology Ventures & Existing Investor Altira Group
HOUSTON, May 20, 2020 /PRNewswire/ -- ThoughtTrace, Inc., a leading Document Intelligence and Contract Analytics software provider, announced today that it has closed a $10 million financing led by McRock Capital, along with Chevron Technology Ventures and existing investor, Altira Group. Scott MacDonald, Co-founder & Managing Partner from McRock will join ThoughtTrace's Board of Directors.
"We are extraordinarily excited to have both McRock and Chevron join the team. McRock brings a great background in the industrial space, which we see as a great fit. In the case of Chevron, they went from being a new customer in 2019 to an investor in 2020," said Nick Vandivere, ThoughtTrace CEO. "With the new capital raise, ThoughtTrace will accelerate its investment in creating AI with unparalleled speed and accuracy, grow strategic partnerships and platform integrations, and add to its existing team of talented professionals, all of which will bring further value to the growing ThoughtTrace customer-base."
ThoughtTrace's AI-powered Document Intelligence platform enables organizations to uncover valuable information buried in contracts and documents in a fraction of the time and cost it would take using traditional review methods. In addition to massive productivity gains, companies that have harnessed this power have drastically reduced OPEX, minimized corporate risk, and even discovered new opportunities worth millions to the bottom line.
Since the 2017 initial product release serving the domestic energy sector, ThoughtTrace has seen aggressive growth year-over-year through expanding energy offerings as well as moving into new vertical markets. Today, the ThoughtTrace technology is trained by subject-matter-experts to serve a wide array of industries including manufacturing, real estate, technology, legal, finance, telecommunications, oil and gas, and renewable energy.
Quotes from investors:
"As the digital strategy of industrial companies becomes even more important in the current market climate, being able to use AI software to discover critical information in thousands of unstructured text documents quickly and cost effectively is transformational," said Scott MacDonald, Co-founder of McRock Capital. "ThoughtTrace allows a company to expand the data analytics from a physical asset to the documentation that governs that asset such as a Power Purchase Agreement for renewable energy."
"Chevron Technology Ventures (CTV) pursues externally-developed technologies and new business solutions that have the potential to enhance the way Chevron produces and delivers affordable, reliable and ever-cleaner energy. ThoughtTrace fits that mandate with the potential to automate the complex, time-consuming, and document-intensive workflows required for our ongoing business operations," said Barbara Burger, President, Chevron Technology Ventures.
"ThoughtTrace is one of those rare technology companies, actually delivering value through Artificial Intelligence and truly reinventing how complex documents are managed. This powerful platform's ability to distill meaning and insight from complex documents has unlocked hundreds of millions of dollars of value across industrial sectors," said Sean Ebert, Partner at Altira and ThoughtTrace Board Member. "We're thrilled to partner with McRock and Chevron Technology Ventures to help ThoughtTrace advance this mission, as we share similar cultures and an unabating commitment to customer success," added J.P. Bauman, Principal at Altira and ThoughtTrace Board Member.
Highlighting the company's momentum, in 2019 the ThoughtTrace platform identified 163 million industry-specific facts out-of-the-box, powering better decisions for customers ranging from Fortune 10s to SMBs. ThoughtTrace, Inc. was also awarded several accolades, including Great Places to Work, Houston Chronicle's Top Workplaces in Houston, announced as a finalist for the IACCM's Innovation & Excellence Award, and secured the highly respected SOC II Type II Compliance.
About McRock:
McRock is the first dedicated Industrial Internet of Things (IIoT) venture capital fund manager focused on the intersection of sensors and software in large industrial markets and smart cities. The McRock team has a unique background of building high-growth venture-backed IIoT companies while also having worked in the power, water, oil and gas industries. McRock is backed by several leading institutional investors and global corporations including Cisco Systems, Caterpillar, Shell, Mitsubishi and Électricité de France (EDF).
Visit www.mcrock capital.com and follow on Twitter @McRockCapital
About Chevron Technology Ventures:
Formed in 1999, Chevron Technology Ventures (CTV), operating as a division of Chevron U.S.A. Inc., pursues externally-developed technologies and new business solutions that have the potential to enhance the way Chevron produces and delivers affordable, reliable and ever-cleaner energy. CTV fosters innovation, supporting vibrant startup ecosystems and championing technology integration internally. Through its investment portfolio and internal use pipeline that trials technologies for use within Chevron, CTV has supported a wide range of innovative companies that are helping to shape the future of energy.
About Altira Group:
Altira Group LLC provides venture capital funding for carefully curated technology products, software and advantaged service offerings that help meet the modern and complex challenges of today's oil and gas industry. Since its founding in 1997, Altira has invested over $1B with partners in over 55 companies. Its Fund VI partners include a select group of U.S. super-independent oil and gas companies that help accelerate the growth of Altira's portfolio companies by serving as large, fast-adopting customers. The Altira team has over half a century of combined experience building successful technology companies. Please visit www.altiragroup.com for more information.
About ThoughtTrace:
ThoughtTrace creates the only industry-specific Document Intelligence and Contract Analytics platform that delivers value on day one with minimal training and setup. Leveraging AI/ML as a complement to human expertise, the ThoughtTrace platform identifies critical obligations in contracts exponentially faster and with greater accuracy than traditional methods. The ThoughtTrace platform reads, organizes, and surfaces data that gives users operational agility, actionable insights, and decision-making superpowers. Learn more at www.thoughttrace.com.
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