text:
Luke Roberts est un acteur anglais, né le  à Woodbridge en Suffolk. Il est connu pour le rôle de Joseph Byrne dans la série Holby City.

Biographie

Filmographie

Films
 2005 :  de Nicolas Forzy : Bruce
 2011 : Pirates des Caraïbes : La Fontaine de jouvence () de Rob Marshall : le capitaine des gardes
 2013 :  de Pearry Reginald Teo : Dracula
 2014 : 300 : La Naissance d'un empire () de Noam Murro : le boucher
 2018 :  de Richard Redwine : Mark
 2022 : The Batman de Matt Reeves : Thomas Wayne

Court-métrage
 2010 :  de Matthew Gustafson : Luke

Séries télévisées
 2001 :  : Ryan Samson
 2001 : Frères d'armes () : Herbert J. Suerth (saison 1, épisode 5 : )
 2004-2005 :  Septième Ciel () : le captaine Dan Peterson (17 épisodes)
 2006 :   : Hunk (saison 1, épisode 7 : )
 2006-2011 :  Holby City : Joseph Byrne (217 épisodes)
 2008 :   : Joseph Byrne (saison 2, épisode 1)
 2011 :  Londres, police judiciaire () : Tom Hartson (saison 6, épisode 7 : )
 2013 :   : Connor Sorvino (saison 1, épisode 10 : Seeing Red)
 2013 : Reign : Le Destin d'une reine () : Simon Westbrook (2 épisodes)
 2014 : Taxi Brooklyn : Rhys (5 épisodes)
 2015 : Dans l'ombre des Tudors () : Harry Norris (5 épisodes)
 2015 :  : Jachim Ben Simon (saison 1, épisode 1 : )
 2016 :  : Arthur Dayne (saison 6, épisode 3 : )
 2016-2017 :  : Woodes Rogers (20 épisodes)
 2017 :  : Éric Beaumont (39 épisodes)

Notes et références

Liens externes

Acteur anglais de télévision
Naissance en octobre 1977
Naissance dans le Suffolk
Acteur de Game of Thrones


text:
22 för många var ett punkband från Stockholm som startades av Henrik Franzén, sångare i Grisen Skriker, tillsammans med Mikael Söderlund, gitarr, och Catarina Silverforsen, bas och sång. 22 för många hade tre olika trummisar under de två-tre år bandet existerade. En av dem var Patrik Wetterström, det är också han som spelar på den LP bandet gav ut 1982.

Bandet hann under sin relativt korta tid producera två kassett-LP ("I afton trans" och okänd), en LP ("22 för många"), och en EP ("Förgiftad av kärlek").

I samband med att bandet lade av så gjordes även "Tokfansmännen i Luftballongen", en LP för Mistlur som aldrig gavs ut. Albumet fanns tillgängligt för nedladdning via en länk som lades ut på sidan punktipset.se. Användaren som gjorde inlägget skrev:

"Innan produktionen var avslutad hann gruppen, av olika anledningar, besluta sig för att skiljas åt.
Kvar var en 'master-press' av plattan, som anförtroddes en utomstående att bevara LPn åt folket.
En gång tidigare har den varit spelat för folk, utlånad till P3 hösten -83

"- Om inget händer innan, se till att folk kan ta del av den om 20 år eller så..."".

Albumet består av 10 stycken outgivna låtar och omslaget var handskrivet av Henrik Franzén.

Länken är, sedan en tid tillbaka, död och ingen ny har lagts ut.

Diskografi
Kassett-LP 1
22 För Många (LP, Futurax FUT 22, 1982)
Förgiftad Av Kärlek (EP, Futurax FUT-EP-3, 1983)
I Afton Trans (MC, TFM 01, 1983)
Tokfansmännen I Luftballongen (Outgiven LP, Mistlur, 1983)

Referenser

Svenska punkband

redpajama_set_name: RedPajamaWikipedia


text:
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NATO Summit 2019: Broad Agreement on Key Issues
NATO leaders managed to agree on key security and defence issues at the 2019 London Summit, despite there being a few differences among the 29 allies. The meeting was overshadowed by the criticism of French President Emmanuel Macron, who believes that NATO is "brain-dead." In a strong reaction, US President Donald Trump called Macron's statements "very nasty," "disrespectful" and even "dangerous." Although this controversy caused some turbulences at the beginning, the NATO leaders issued a joint 'London Declaration' on 4 December. at the end of the two-day summit.
During a media briefing NATO Secretary General Jens Stoltenberg summarized the results of the summit, which not only celebrated NATO's 70th anniversary but also marked the 30th anniversary of the fall of the Iron Curtain in 1989. He stated the meeting "has once again demonstrated that NATO remains the only place where Europe and North America discuss, decide and act every day together on strategic issues that concern our shared security." Among the differences which could not be resolved were the political strategy on how to tackle Russia, the right approach for northern Syria and the burden-sharing debate regarding increasing defence spending to the agreed 2% of GDP figure by 2024.
He said the Alliance has taken decisions to substantially improve NATO's Readiness Initiative to respond to any threat, at any time, from any direction. The major goal of this initiative is to have 30 battalions, 30 air squadrons and 30 combat ships available within 30 days or less (also dubbed the 'Four 30s'). He stated that the leaders declared space as the fifth operational domain alongside air, land, sea and cyber.
The Secretary General emphasized NATO will continue its dual-track approach – of dialogue and defence – towards Russia. The leaders discussed Russia's ongoing deployment of new intermediate-range missiles (specifically the SSC-8), which brought about the demise of the Intermediate-Range Nuclear Forces (INF) Treaty and continuess to pose significant risks to Euro-Atlantic security. But Russia was not the only issue.
The 'London Declaration' addressed several more challenges where the Alliance is facing distinct threats emanating from other strategic directions. "Terrorism in all its forms and manifestations remains a persistent threat to us all. State and non-state actors challenge the rules-based international order. Instability beyond our borders is also contributing to irregular migration. We face cyber and hybrid threats." Therefore, NATO allies are increasing their tools to respond to cyber-attacks and strengthening their ability to prepare for, deter and defend against hybrid tactics that seek to undermine the security of the member states. For the first time ever, the rise and ambitions of China were addressed in a NATO summit communiqué, with the leaders recognizing that China's growing influence presents both opportunities and risks.
As expected by political observers, NATO also discussed the commitments of its member states to increasing their defence spending. The 'London Declaration' stated "Through our Defence Investment Pledge, we are increasing our defence investment in line with its 2 % and 20 % guidelines, investing in new capabilities and contributing more forces to missions and operations. Non-US defence expenditure has grown for five consecutive years; over US$130 billion more is being invested in defence."
The leaders reaffirmed their commitment to a strong defence posture to protect all its members. "We are further strengthening our ability to deter and defend with an appropriate mix of nuclear, conventional and missile defence capabilities, which we continue to adapt. As long as nuclear weapons exist, NATO will remain a nuclear alliance," the Declaration underlined.
The Alliance remains committed to the preservation and strengthening of effective arms control, disarmament and non-proliferation, taking into account the prevailing security environment. Allies are committed to full implementation of the treaty on the non-proliferation of nuclear weapons in all its aspects, including nuclear disarmament, non-proliferation and the peaceful uses of nuclear energy.
Mr Stoltenberg reiterated NATO's commitment to improving long-term security and stability in Afghanistan. He made it clear that NATO remains convinced that a political solution is necessary to end the long and dreadful conflict with the Taliban in Afghanistan.
The NATO leaders invited Mr Stoltenberg to work on a Council-agreed proposal for a forward-looking reflection process under his auspices, drawing on relevant expertise, to further strengthen NATO's political arm - a controversial issue which had been articulated by many allies before the summit.
Dr Theodor Benien
Despite several differences, NATO leaders managed to agree on key security and defence issues. (Photo: NATO)
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redpajama_set_name: RedPajamaCommonCrawl


And all the others vowed the same.
awful hour awaiting him might pass him by.
asleep. He said to Peter, "Simon, are you asleep?
Couldn't you watch with me even one hour?
he said, "Go ahead and sleep. Have your rest.
a crowd of men armed with swords and clubs.
exclaimed, and gave him the kiss.
the guards, warming himself by the fire.
against Jesus, so they could put him to death.
they didn't get their stories straight!
the guards slapped him as they took him away.
66 Meanwhile, Peter was in the courtyard below.
right hand of the power. See Ps 110:1. 14:62c See Dan 7:13.
72 And immediately the rooster crowed the second time.
And he broke down and wept.
Jesus said nothing, much to Pilate's surprise.
to release a prisoner as usual.
each sorrow and how it affects us.


text:
Ophelia (altgriechisch: ) ist ein weiblicher Vorname.

Herkunft und Bedeutung
Der Name Ophelia leitet sich vom griechischen Wort  "Hilfe", "Nutzen" ab. Dieser altgriechische Name wurde vom italienischen Renaissance-Dichter Jacopo Sannazaro im Gedicht Arcadia verwendet und erlangte so neue Bekanntheit. Etwa ein Jahrhundert später griff William Shakespeare den Namen Ophelia in seinem Drama Hamlet wieder auf.

Verbreitung
Seit dem 19. Jahrhundert wird der Name wieder häufiger als Vorname vergeben.

In Deutschland ist der Name verhältnismäßig selten, erfreut sich jedoch in den vergangenen Jahren wachsender Beliebtheit. Am häufigsten wurde der Name in Heidelberg vergeben.

Varianten

 Aserbaidschanisch: Ofeliya
 Bulgarisch:
 Französisch: Ophélie
 Isländisch: Ófelía
 Italienisch: Ofelia
 Portugiesisch: Ofélia
 Russisch:
 Spanisch: Ofelia
 Ukrainisch:

Namensträgerinnen
 Ophelia Hoff-Saytumah, liberianische Kommunalpolitikerin, Unternehmerin und  Bürgermeisterin der Hauptstadt Monrovia (2001–2009)
 Ophelia Lovibond (* 1986), britische Schauspielerin
 Ophelia Johanna Nick (* 1973), deutsche Politikerin, Veterinärin und Unternehmerin
 Ophelia Shtruhl (1940–2022), israelische Schauspielerin
 Ophelia Vilarova (* 1960), deutsche Tänzerin und Choreografin
 Ofelia Zepeda (* 1952 oder 1954), US-amerikanische Autorin, Angehörige der Tohono O'Odham

Siehe auch

 Ophelia, Lied von The Lumineers
 Ophelia (Schiff)
 Ophelia (Gattung)
 Ophelia (Film)
 Ophelia (Mond)

Einzelnachweise

Weiblicher Vorname
Literarischer Personenname


text:
Mature CD8+ T lymphocyte response to viral infection during fetal life
Arnaud Marchant, … , Andrew J. McMichael, Hilton Whittle
Citation Information: J Clin Invest. 2003;111(11):1747-1755. https://doi.org/10.1172/JCI17470.
Article Vaccines
Immunization of newborns against viral infections may be hampered by ineffective CD8+ T cell responses. To characterize the function of CD8+ T lymphocytes in early life, we studied newborns with congenital human cytomegalovirus (HCMV) infection. We demonstrate that HCMV infection in utero leads to the expansion and the differentiation of mature HCMV-specific CD8+ T cells, which have similar characteristics to those detected in adults. High frequencies of HCMV-specific CD8+ T cells were detected by ex vivo tetramer staining as early as after 28 weeks of gestation. During the acute phase of infection, these cells had an early differentiation phenotype (CD28–CD27+CD45RO+, perforinlow), and they acquired a late differentiation phenotype (CD28–CD27-CD45RA+, perforinhigh) during the course of the infection. The differentiated cells showed potent perforin-dependent cytolytic activity and produced antiviral cytokines. The finding of a mature and functional CD8+ T cell response to HCMV suggests that the machinery required to prime such responses is in place during fetal life and could be used to immunize newborns against viral pathogens.
Arnaud Marchant, Victor Appay, Marianne van der Sande, Nicolas Dulphy, Corinne Liesnard, Michael Kidd, Steve Kaye, Olubukola Ojuola, Geraldine M.A. Gillespie, Ana L. Vargas Cuero, Vincenzo Cerundolo, Margaret Callan, Keith P.W.J. McAdam, Sarah L. Rowland-Jones, Catherine Donner, Andrew J. McMichael, Hilton Whittle
TCR BV spectratypic analysis of CD8+ T lymphocytes and phenotypic analysis of BV-specific CD8+ T cells from control and HCMV-infected newborns. (a) Spectratypic analysis. CDR3 length distribution was Gaussian for all BV families of control newborn no. 9 (shows five representative families), indicating a naive CD8+ T cell repertoire. Similar results were obtained in control newborns no. 8 and 12. In contrast, alterations in CDR3 length distribution were detected in BV16, BV18, and BV23 of case no. 7, indicating oligoclonal expansions of CD8+ T cells. (b and c) Phenotypic analysis. Expression of HLA-DR, CD27, and CD28 by BV2, BV14, BV16, BV18, and BV23 CD8+ T cells of control no. 9 and case no. 7. High proportions of CD8+ T lymphocytes from HCMV-infected newborns had a phenotype of activated (b) and differentiated (c) cells. These alterations were primarily observed in the BV families that included oligoclonal expansions in the spectratypic analysis (BV16, BV18, and BV23).


text:
US Mint Liberty Head Gold Dollars
Gold $1 Type-1
(Designed by James B. Longacre, Reeded Edge, 13-15mm, 1.672g, 900 Fine)
Shop One Dollars Gold Pieces
The discovery of gold at Sutter's Mill in 1848 prompted Congress to demand that U.S. gold coinage be expanded. The March 3, 1849 Act authorized not only the first and well-known $20 gold pieces but also the first gold dollars, thereby creating the nation's smallest and largest regular-issue gold coins in one fell swoop. The designer of both new coins was U.S. Mint Chief Engraver, James Barton Longacre. Both had a similar obverse design of a left-facing portrait of Miss Liberty with a coronet crown in her hair. The Dollar Liberty head is encircled by 13 stars, symbolizing the 13 original colonies, as does the twenty, but the famed Double Eagle features the date on the obverse.
In light of its small 13mm size, the reverse bears the denomination "1 DOLLAR" and the date within a simple wreath, which is encircled by the inscription, UNITED STATES OF AMERICA. The initial design remained in use until 1854, when a feather headdress replaced the coronet, which type is generally referred to as the Indian Head or Princess. In 1856 the type was changed slightly by enlarging the size of the head. Thus, there are three distinct types of gold dollars, but they are generally collected as one 81-coin series, including major varieties.
Throughout U.S. history, people have grumbled that silver dollars were too large and heavy to carry around. Gold dollars posed a dramatically different problem, because being smaller than a half dime or even 3-cent silver pieces, they could easily be mishandled and lost. The tiny coins had strong use for some time, when their purchasing power was akin to a full day's wages or more for many Americans in the day. With the series historic era of birth and their striking gold beauty and historical significance, they enjoy enormous respect and market support from collectors today, for while they may be tinny in size, their value and unquestionable collector appeal is huge, especially recognizing that gold dollars were struck at the five most historied mints: Philadelphia (no mint mark), Charlotte (C), Dahlonega (D), New Orleans (O) and San Francisco
Louis Eliasberg, Sr.
The earlier Type-1 dollars are scarce but available in grades up through Mint State-64, but they get scarce above that level. However, later dates in the series offer ample greatly-appealing gems at generally affordable price levels. Although the series can be collected by the entire circulating date and mintmark, the general rarity of high grade pieces limits collectors ability to secure well-struck and nicely-preserved specimens. One very appealing way to get started is with a specialized collection of the 5-piece mintmark collection. Alternatively, a large number of the low mintage coins made from 1880s were saved in superb condition, and many collectors assemble them into what is that decade's spectacular, ten-piece short set.
One of the few complete collections of gold dollars amassed was that of the late Louis Eliasberg, Sr. Acquiring the collection of the Clapp Family intact, the Baltimore financier added whatever pieces were missing or warranted upgrading. This fabulous collection was sold at auction in 1982, and the famed Eliasberg pedigree is still highly sought by collectors today.
Click here to download the Collector's Checklist
HISTORY OF SERIES
In 1854, the Mint took steps to remedy the size problem, but without changing the gold dollar's weight. It increased the coin's diameter from 13 to 15 millimeters. This Type-2 issue produce a coin that was noticeably larger, considerably thinner and, hopefully, less likely to get lost. Initially, gold dollars had a head of Miss Liberty much like the one on the Double Eagle. When US Mint Director, James R. Snowden, ordered changes for the larger coin, Longacre had a new model available, drawing from the one he had just designed for the three-dollar gold piece. He patterned the new gold dollar after it, where its obverse features a left-facing portrait of a female figure wearing a fancy headdress. Though this female figure is frequently described as being an "Indian Princess" or "Indian Head" type, Longacre's figure is clearly Miss Liberty, with a fancy headdress, and certainly not your standard American Indian garb. The obverse also replaced the 13 stars to take the UNITED STATES OF AMERICA then no longer on the reverse. The Type-2 reverse design shows the date and denomination within a wreath of corn, cotton, wheat and tobacco.
Being 15% larger in diameter, this Type-2 gold dollar was easier to keep track of — and less likely to get lost — than its predecessor had been. However, the new Type-2 dollar had another shortcoming and serious deficiency of its own, because Longacre had made the relief too high on the obverse. As a consequence, very few examples were fully struck and virtually all the coins wore down quickly in circulation, deteriorating rapidly into all-but-dateless disks with fading features. Very few Type-2 examples exhibit sharp details in the hair along with the word DOLLAR and the date and, even the designer's initial L, located on the truncation of the bust, is often barely visible. It seems that branch-mint issues are particularly weak.
Because of the striking difficulties, Longacre had to remedy the problem and the Type-2 dollar lasted only until 1856 before giving way to the third type. During its brief existence, barely 1.6 million Type-2 examples were produced, with the Philadelphia issues of 1854 and 1855 accounting for the vast majority. The three southern branch mints all made the coin in 1855, but outputs were extremely small at Dahlonega and Charlotte, where mintages totaled just 1,811 and 9,803 coins, respectively. The New Orleans mint produced 55,000 coins that year. The new branch mint in San Francisco was the only mint to produce this type in 1856. Given its relief problems and its small total population, the Type-2 is exceptionally elusive in mint condition. It is rare in Mint State-65, and extremely rare above that level. It has been estimated that less than 1% of the Type-2 dollar mintage still exists in any grade. Unfortunately, the beautiful little coins wore down so quickly when exposed to circulation that within a few years, much of the total output had been rendered almost illegible.
James B. Longacre
In 1856, a new Longacre design, which is the Type-3 (issued through 1889) rectified the wear problem. While reducing the relief, he made the portrait larger. Although the size and configuration of the portrait and other elements differ on the Type-2 and Type-3 gold dollars, both have essentially the same Indian Princess design. Besides enlarging the portrait's size and reducing its three-dimensional depth, Longacre also moved the inscription UNITED STATES OF AMERICA closer to the border on the obverse, where it encircles the "Indian Head." Type-3 gold dollars are far more plentiful in choice mint condition than the two earlier types.
Type one, two . . .three's a charm, indeed, because from then on, the gold dollar's size and durability both proved satisfactory, and production continued without interruption for more than three decades until the denomination was discontinued in 1889. This final type had a 33-year lifespan and coincided with one of the most turbulent periods in American history, when just a third of a century saw the Civil War, the Reconstruction Era and the Indian Wars in the West, which all left indelible marks on the nation's consciousness. The small dollar gold coin served American commerce well from the eve of the California Gold Rush, through the Civil War and up to the Gay Nineties.
View current online inventory at the button below, and get in touch with Monaco Rare coins.


text:
D.C. Files New Lawsuit Against Facebook Over Data Mining by Cambridge Analytica
Posted 2:36 PM, December 19, 2018, by Associated Press, Updated at 02:37PM, December 19, 2018
A laptop showing the Facebook logo is held alongside a Cambridge Analytica sign at the entrance to the building housing the offices of Cambridge Analytica in central London on March 21, 2018. (Credit: Daniel Leal-Olivas / AFP / Getty Images)
The District of Columbia has fired the latest legal salvo against Facebook with a lawsuit seeking to punish the social networking company for allowing data-mining firm Cambridge Analytica to improperly access data from as many as 87 million users.
The complaint filed Wednesday by Washington, D.C., Attorney General Karl Racine alleges that Facebook misled users about the security of their data and failed for years to properly monitor third-party apps.
"We're seeking to hold Facebook accountable for jeopardizing and exposing the personal information of tens of millions of its users," Racine said. "We hope this lawsuit will ensure Facebook takes better care with its data."
Facebook said it's reviewing the complaint and will continue to hold discussions with Racine and attorneys general scattered across the country who have raised red flags about the company's mishandling of personal information.
The lawsuit is the latest blow to Facebook in a year fraught with privacy scandals and other problems for the world's biggest social network.
Facebook already has been buried in an avalanche of other lawsuits filed in federal and state courts, as well as regulatory investigations in both U.S. and Europe into whether the company has violated laws by repeatedly allowing unauthorized access to the personal information of the nearly 2.3 billion people on its private network.
Most of the headaches began in March after revelations that Cambridge Analytica, which had been working with the 2016 campaign of President Donald Trump, had been able to vacuum up potentially valuable information about U.S. voters off of Facebook profiles.
That bombshell triggered congressional hearings and changes in what sorts of data Facebook lets outside developers access.
The Washington lawsuit alleges that about half of the District of Columbia's roughly 700,000 residents had their data scooped up by Cambridge Analytica in violation of local laws. That is a relatively small number, but the case could attract outsized attention, given it will unfold in the nation's capital, where U.S. lawmakers are mulling imposing new regulations restricting how much personal information Facebook and other internet companies can collect on their mostly free services.
"Every time we see another lawsuit, or investigation, it helps keep attention on what has been happening and should help create a framework for holding Facebook accountable," said Mike Chapple, an associate teaching professor of information technology, analytics and operations at the University of Notre Dame. "People are getting fed up with having their information mishandled."
It remains unclear, however, whether the allegations that are being made against Facebook in the District of Columbia and in other complaints were against the law at the time, said Dora Kingsley Vertenten, professor of public policy at the University of Southern California.
"It looks like they are throwing spaghetti against the wall and seeing what sticks," she said.
Facebook has repeatedly assured lawmakers, regulators and the media that it is battening down its hatches in an effort to do a better job preventing unauthorized access to the pictures, thoughts and other personal information that its nearly 2.3 billion users typically intend to share only with friends and family.
But revelations of more privacy lapses continue to crop up, sometimes through breakdowns that Facebook has periodically disclosed, such as a software flaw that improperly exposed the photos of about 7 million users, or other times though media investigations such as a New York Times report documenting the company's agreements to share its audience's information with its partners, including Microsoft and Netflix.
With each breakdown, Facebook risks losing credibility with both its audience and the advertisers whose spending generates most of the company's revenue. That threat has spooked investors, causing Facebook's stock price to plunge by more than 24 percent so far this year, wiping out more than $100 billion in shareholder wealth.
Some of the lawsuits allege Facebook misled investors as its privacy problems unfolded. Other lawsuits, as well as regulatory inquiries by the U.S. Federal Trade Commission and the Irish Data Protection Commission, are focused on Facebook's sharing of personal information with other companies. Depending on how they turn out, the lawsuits and government probes could cost Facebook billions of dollars more in penalties.
Facebook Allowed Netflix, Other Streaming Services, to See User's Private Messages, N.Y. Times Reports
Internal Facebook Emails Show How Company Sought to Leverage User Data, U.K. Parliament Committee Says
Internal Documents Facebook Fought to Keep Private Obtained by UK Parliament
Filed in: Local News, Nation/World
Topics: Cambridge Analytica, Donald Trump, Facebook, washington d.c.
Federal Lawsuit Seeks to Stop L.A. From Seizing Homeless People's Belongings in Encampment Sweeps
Crowd Forms as LAPD Investigates Fatal Shooting of Woman in East Hollywood Alley
FTC to Fine Facebook About $5 Billion in Privacy Violations Settlement: WSJ
Facebook Launching App That Will Pay for Data on Which Apps You Use
Facebook Expecting Fine of Up to $5 Billion from Agency Investigating User Privacy Violations
Court Dismisses Lawsuit Accusing Trump of Illegally Profiting Off Presidency Through Luxury Hotel
Facebook's New Plan Doesn't Protect Your Privacy
Local News Nation/World
Gay Dating App Grindr Is the Latest Victim of U.S.-China Tensions
Trumps Sue Deutsche Bank and Capital One to Keep Financial Records From Congress
Apple Splits up iTunes, Offers New Privacy Features as iPhone Sales Continue to Drop
Facebook Auto-Generates Videos Celebrating Extremist Images
WhatsApp Flaw Let Spies Take Control of Dozens of Phones With Calls Alone
Local News Politics
State Lawmakers Hand Victory to Tech Industry, Rejecting Effort to Expand Data Privacy Law
Facebook Announces 'Libra,' Its Own Digital Currency for Users
Federal Data Shows Drugmakers Steeply Increased Opioid Shipments as Crisis Grew


text:
Liyanage P. Perera, Ph.D.
Building 10, Room 4N114
pereral@mail.nih.gov
Associate Scientist
Lymphoid Malignancies Branch
Team Member Of:
Louis M. Staudt, M.D., Ph.D.
lstaudt@mail.nih.gov
Dr. Perera received his Ph.D. from the F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD in 1990 and joined the Laboratory of Clinical Investigation, NIAID in 1992 as a senior staff fellow. In 1997, he moved to the Metabolism Branch of NCI (now the Lymphoid Malignancies Branch) as a staff scientist and currently leads a translational research program. His research focuses on immunotherapeutic approaches including the generation of engineered T cells with chimeric antigen receptors (CAR) and targeted combinatorial drug regimens as therapeutic modalities for the treatment of cancer, infectious diseases, and autoimmune disorders. He is an inventor with two US patents (No. 5,747,272 and No.8,663,622), a recipient of several Federal Technology Transfer awards, and an NIH merit award.
1 The use of immune enhancing cytokines as molecular adjuvants in vaccines against infectious diseases and cancer: The development of effective long-lasting immunotherapy and immunoprevention for chronic infectious diseases such as malaria, tuberculosis, HCV, AIDS, and cancer represents a major challenge. Our research has focused on the approach of using immune enhancing cytokines, particularly IL-15, GM-CSF and Flt3 ligand to enhance the efficacy of several vaccine candidates. Central to our vaccine developmental efforts is the use of the live vector MVA vaccinia delivery platform in addition to LC16M8 and Wyeth vector platforms with integrated cytokines. These vaccines are capable of delivering the vaccine cargo directly into antigen presenting dendritic cells by efficient infection, concomitant with the induction of danger signals to activate Toll like receptor pathways pivotal for priming a robust effector T cell response. Using this technology we have demonstrated the enhancement of CD8 T cell-mediated immune responses as well as antibody-mediated humoral immune responses to several candidate vaccine antigens that are currently being evaluated. Several vaccinia-based vaccine candidates that are at various stages of pre-clinical development include a penta-valent HCV vaccine that expresses E1, E2, NS3, NS4, and NS5B in tandem; a multivalent HIV vaccine that expresses env, gag, pol, nef and tat; dual and single agent biodefense vaccines against smallpox and anthrax; a multivalent tuberculosis vaccine that expresses ESAT6, Ag85A, Ag85B, HSP65, and Mtb 39A; a multi-valent malaria vaccine that expresses CSP, AMA-1, MSP-1 SSP2; a multi-valent universal influenza vaccine that expresses H5, NA, M1, M2, and NP and is effective against pandemic and emerging influenza strains; EBV and HSV-2 herpes viral vaccines, a hexavalent human papilloma virus (HPV) vaccine that expresses L1, E6 ,E7 of HPV 16 and L1, E6, E7 of HPV 18; a breast cancer vaccine targeting the HER2 oncogene, triple-adjuvanted full-length MAGE-A3 that is over-expressed in a variety cancers including melanoma as an immune-therapeutic vaccine and a trivalent prostate cancer vaccine that expresses full-length Prostate Specific Antigen (PSA), Prostate Specific Membrane Antigen (PSMA), and Prostatic Acid Phosphatase (PAP) polypeptides in tandem with IL-15 as a molecular adjuvant. Details regarding this vaccine platform are available at the Office of Technology Transfer, National Institutes of Health website: http://www.ott.nih.gov/Technologies/abstractDetails.aspx?RefNo=726
2. Blockade of IL-15 and other common gamma chain cytokine signaling as a therapeutic modality in autoimmune disorders: It is increasingly becoming clear that IL-15 may play a central role in inflammatory autoimmune diseases. Recent evidence suggests that in a number of inflammatory auto-immune diseases including celiac disease, rheumatoid arthritis, and autoimmune diabetes, activated T cells destroy target parenchymal cells predominantly via a mechanism that is independent of TCR engagement, but is very much dependent upon the NKG2D-MIC pathway. IL-15 up-regulates the expression of MIC expression in the parenchymal tissues and induces the expression of the activating NKG2D receptor as well as DAP10, and phosphorylates ERK involved in the NKG2D-mediated signaling cascade in T cells, thereby perpetuating a vicious cycle of continuous tissue destruction and chronic inflammation. Blockade of TNF using TNF-specific monoclonal antibodies or soluble TNF receptor immunoglobulin fusion proteins has revolutionized the therapy of select autoimmune diseases. However, these TNF directed approaches do not provide effective therapy for all patients with autoimmune diseases and newer therapeutic targets are needed. Furthermore, although TNF directed therapy has an anti-inflammatory effect it has no impact on self reactive memory T-cells that may play a role in the pathogenesis and maintenance of autoimmune diseases. Collectively these observations suggest that blockade of IL-15 activity may be an effective therapeutic modality in the management and treatment of inflammatory auto-immune disorders.
Ongoing studies encompass autoimmune type I diabetes, psoriasis, systemic lupus erythematosus (SLE), ALPS, and autoimmune airway hypersentivity with the use of relevant preclinical small animal models of these disease entities.
Tofacitinib, a janus kinase inhibitor demonstrates efficacy in an IL-15 transgenic mouse model that recapitulates pathologic manifestations of celiac disease
Yokoyama S, Perera PY, Waldmann TA, Hiroi T, Perera LP.
J. Clin. Immunol.. 33: 586-94, 2013. [ Journal Article ]
The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use
Perera PY, Lichy JH, Waldmann TA, Perera LP.
Microbes Infect.. 14: 247-61, 2012. [ Journal Article ]
Malaria infections do not compromise vaccine-induced immunity against tuberculosis in mice
Parra M, Derrick SC, Yang A, Tian J, Kolibab K, Oakley M, Perera LP, Jacobs WR, Kumar S, Morris SL.
PLoS ONE. 6: e28164, 2011. [ Journal Article ]
IL-15 adjuvanted multivalent vaccinia-based universal influenza vaccine requires CD4+ T cells for heterosubtypic protection
Valkenburg SA, Li OT, Mak PW, Mok CK, Nicholls JM, Guan Y, Waldmann TA, Peiris JS, Perera LP, Poon LL.
Proc. Natl. Acad. Sci. U.S.A.. 111: 5676-81, 2014. [ Journal Article ]
Protective-antigen (PA) based anthrax vaccines confer protection against inhalation anthrax by precluding the establishment of a systemic infection
Merkel TJ, Perera PY, Lee GM, Verma A, Hiroi T, Yokote H, Waldmann TA, Perera LP.
Hum Vaccin Immunother. 9: 1841-8, 2013. [ Journal Article ]
Dr. Perera received his Ph.D. from the F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD in 1990 and joined the Laboratory of Clinical Investigation, NIAID in 1992 as a senior staff fellow. In 1997, he moved to the Metabolism Branch (now the Lymphoid Malignanicies Branch) of NCI as a staff scientist and currently leads a translational research program. His research focuses on immunotherapeutic approaches including the generation of engineered T cells with chimeric antigen receptors (CAR) and targeted combinatorial drug regimens as therapeutic modalities for the treatment of cancer, infectious diseases, and autoimmune disorders. He is an inventor with two US patents (No. 5,747,272 and No.8,663,622), a recipient of several Federal Technology Transfer awards, and an NIH merit award.


text:
SB 234: Reducing Landfill Accumulation
In this post, I present the first of two excerpts from my written comments on SB 234, which would make universal recycling a reality for every Delaware household. In this excerpt, I look at the economic value of reducing landfill accumulation, using methods I first wrote about four years ago:
SB 234 finds "it is in the interest of all Delawareans to minimize the need for future landfill capacity and the associated costs by reducing the flow of waste to landfills."
I have created a simple model of the relative costs of postponing the siting and construction of a new landfill to replace Cherry Island Landfill (CIL)—if the land could be found at any price. This simplified calculation assumes that the CIL would reach its capacity in 2035 under current trends, and that a zero waste strategy would extend its useful life a further 25 years to 2060.
Five years ago, the replacement cost for the CIL was estimated to be $106 million—a figure that is almost certainly low given any reasonable projection for land costs over the next 25 to 50 years. Thus I have included the figure of $250 million as a comparison, though the cost 25 years from now could go even higher.
I calculated the present value of postponing CIL replacement from 2035 to 2060 using a discount rate of 4.66%, the current AAA municipal bond rate. I found that postponing CIL replacement by 25 years would yield present value (PV) savings—savings in today's dollars—of between $9.75 million and $23 million:
As a rough rule of thumb, postponing CIL replacement through a zero waste strategy would create roughly $9-10 million in present value savings for each $100 million of future costs postponed.
Of course, we may not be able to find the required 500 to 800 acres at any cost. The footprints of DSWA's major landfills range from 513 acres (CIL) to 835 acres (Sandtown), which comes to roughly 12 to 20 40-acre farms. If a site for a new landfill cannot be found, we would be looking at higher costs for waste disposal, including transportation costs to a downstate or out of state landfill.
If Cherry Island closes and a replacement can't be found in New Castle County, we could see a daily parade of trash trucks—one every minute for nine hours day, seven days a week—running down Route 1 to downstate Delaware.
SB 234 is scheduled to come up for a vote in the Senate on Thursday.
Great analysis, Tom, very sound thinking. Thank you! Makes the case why the Delaware General Assembly could & should support Statewide recycling to the tune of about $10 million a year from the General Operating Fund.
Having said that, with a flat revenue stream, where does Delaware find the dollars.
SB234 proposes a SALES TAX! -- okay, the bill calls it a fee. And they hope the SALES TAX, 4 cents on certain beverage containers, will go away after 4 or 5 years.
This from a Legislature which never met a TAX it didn't like. I was there in 1975-76 when they passed the GROSS RECEIPTS TAX during a recession with the promise that it would be temporary. We're all still laughing that we believed that one!
Rather than gut the 1982 Bottle Bill, which SB234 proposes to do, to alleviate that incalculable burden on retailers of redeeming the deposit on empty Coca Cola bottles (that's a joke folks), just Escheat the Abandoned Property from the Unredeemed Deposits and revert it to the General Operating Fund. The amounts zero out, and we don't allow in the dreaded SALES TAX.
Thanks again, Tom, for a great analysis.
Tom Noyes said...
Thanks for your kind comments. As for the fee, the retailers, the grocery stores, restaurant association and beer distributors all voiced their support for the bill at last week's hearing.
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Statewide Recycling Bill To Be Introduced Today
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Report Finds No Misconduct in "Climategate"
Obama and the Markets
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Tory Lanez Transforms Into "International Fargo" On "TOUCHDOWN"
Badmon Tory pulls up with "TOUCHDOWN."
Quavo grabs both guest spots on Saweetie's soon-to-be-released EP.
SahBabii celebrates his birthday with a trio of new songs.
Mila J shares new project.
Bishop Nehru delivers his new EP "Nehruvian Holidays."
Vic Mensa will go public with his next body of work, in the month of December.
A.CHAL drops off "LA DUEÑA."
BlocBoy JB & Lil Uzi Vert tackle a popular sample for "Don't Say That."
Brent Faiyaz Has A Solid Single On His Hands With "Poundz"
Brent Faiyaz returns today with a brand new EP.


palifermin - patient information, description, dosage and directions.
Palifermin is a human keratinocyte growth factor (KGF) produced by recombinant DNA technology.
Palifermin is used to reduce the chance of developing sores and ulcers in the mouth and to shorten the time with sores or ulcers in patients with blood cancers who receive high doses of chemotherapy and radiation therapy before bone marrow transplants.
Palifermin may also be used for purposes other than those listed in this medication guide.
Palifermin is given as an I .V. (in the vein) infusion for three days before you get chemotherapy and then three days after. Palifermin should not be given to you within 24 hours of your chemotherapy treatment.
skin and mucus membrane side effects such as rash, redness, swelling, itching, unusual sensations in the mouth, tongue color change, tongue thickening and changes in taste.
Before you start receiving palifermin, tell your health care professional if you are allergic to other products made from E. coli proteins.
Palifermin can cause possible tumor growth if it is used for nonblood related cancers. Talk to your doctor if you have any questions.
Palifermin has not yet been shown to be safe and effective in patients being treated for forms of cancer other than leukemia or lymphoma.
Palifermin is in the FDA pregnancy category C. This means that it is not known whether palifermin will be harmful to an unborn baby. Do not use palifermin without first talking to your doctor if you are pregnant or could become pregnant during treatment. Discuss with your doctor the appropriate use of birth control during treatment with palifermin if necessary. It is not known whether palifermin passes into breast milk. Do not take palifermin without first talking to your doctor if you are breast feeding a baby.
How should I use palifermin?
Palifermin is administered as an intravenous (into the vein) infusion. Most often, palifermin is administered in a hospital or clinic setting. If you are administering palifermin at home, your healthcare provider will give you detailed instructions regarding preparation, administration, and storage of the medication.
Your doctor will determine the correct amount and frequency of treatment with palifermin Talk to your doctor if you have any questions or concerns regarding the treatment schedule.
Palifermin vials should be stored in the refrigerator. Palifermin vials should be protected from light. Store palifermin in the original carton until it is used. Do not freeze palifermin products.
Contact your doctor if you miss a dose of palifermin.
If an overdose of palifermin is suspected, seek emergency medical attention or contact your healthcare provider immediately.
Symptoms of a palifermin overdose are not well known but may include headache.
60 mcg/kg IV bolus daily for 6 doses administered on 3 consecutive days prior to and 3 consecutive days after myelotoxic therapyPrior to myelotoxic therapy, administer the third dose no later than 24 to 48 hours prior to initiation of myelotoxic therapy.Following myelotoxic therapy, administer the first dose no sooner than 4 days after the most recent palifermin administration and on the same day of hematopoietic stem cell infusion.
Palifermin can interact with heparin. If heparin is used to maintain your IV, your IV must be flushed with saline before and after palifermin.
Other medications may interact with palifermin. Talk to your doctor and pharmacist before taking any other prescription or over-the-counter medicines, including vitamins, minerals, and herbal products, during treatment with palifermin.
Your healthcare provider may have additional information about palifermin that you may read.
Copyright 1996-2006 Cerner Multum, Inc. Version: 2.02. Revision Date: 4/12/2009 4:45:40 PM.


text:
Arondismentul Vannes (în ) este un arondisment din departamentul Morbihan, regiunea Bretagne, Franța.

Subdiviziuni

Cantoane
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Vannes


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text:
Nestor Aparicio
ColumnNes
Crab Cake Tour
WNST Classic
Luke Jones
Music Classic
BusinessSportsCollege SportsRavensFeatured
Football and end of the year finance
By Baltimore Positive
Daily Discussions
Leonard Raskin and Nestor discuss end of year football and college bowl season and some finance tips to be aware of before the ball drops on 2022.
SUMMARY KEYWORDS
game, crabs, week, quarterback, play, thinking, year, baltimore, 31st anniversary, lamar, raskin, run, cincinnati, big, hardball, eat, wife, playoffs, ravens, pittsburgh
W N S, T, Towson, Baltimore and Baltimore positive. We're taking the Maryland crabcake tour back out on the road twice this week for my 31st anniversary Baltimore radio. It's all brought to you by our friends at the Maryland lottery I'll be giving away some ravens scratch off tickets as well. We're gonna Hootenanny we're gonna be a failure on Friday honoring Dan Rodricks. The great will Schwartz was the one time producer of my television show with Lawrence Taylor and the buddy Ryan back in the day. That'd be families on Friday morning. I think Ross is going to be joining us in the Maryland lottery as well. Big thanks to our friends at Goodwill as well as when donation 866 90 nation 0% financing on Windows so go get them and we'll be back next Thursday in Dundalk at Costas celebrating my 31st anniversary so it's three things really going on. It's a holiday event. 31st anniversary on radio and Rock and Roll Hall of Famer the great drummer from the Go Go's of Dundalk. Jean is shocked doing a extended conversation as well as the hammer Jacks documentary folks. This guy has been a Costas over the weekend for the big crabs. Yes, they have the big and he's also been at the Ravens game but Ohio State didn't get their ass kicked this week and that they are you sorry I didn't mean to get you get you off on the wrong foot of your letters.
No worries. No look. Hey, we're going to the playoffs right off. Yeah, how about that they're going to the playoffs you get mad and you still get a recipe you get another chain man. 10 in one if you watched the Utes USC I don't know if you're a fan. That was a great game. I thought that was a great game, and the Utes beat up USC and at the end of the game head coach from the Utes Mr. I believe Willingham jumped up on the set of Fox Sports and Urban Meyer was up there and I did not know this little tidbit. Urban Meyer hired him as one of his assistant coaches when he was head coach at the Utes back in 2003. So urban was given the old hug, hugging them all up and saying how great is when was and then coach for the youth said You're welcome Ryan day, because USC was for Ohio State was five, Alabama was six. So lo and behold at the end of the day, Ohio State sneaks into backdoor gets in the playoffs and what do they get for their trouble? A trip to the Peach Bowl to play number one Georgia on New Year's Eve at eight o'clock at night. Game home game for the Bulldogs That's right, a home game for the quarterback that I believe should win the Heisman trophy. If
you do weeks ago before they got their ass kicked by Michigan, you were a believer that they were national championship game, you know, caliber.
I thought it would be good to see. Georgia. I thought it'd be good to see them play Georgia and the final now they're going to have to play him in the semifinal.
Okay, well,
we'll see. You either put up or shut up.
Are you a boy headed to introducing peach tree dancing for the new year and
the wife we're gonna Peach Out and the wife we're gonna three of us are gonna Peach Out and we now have changed our plans around and we will spend New Year's Eve in the Peach State. We down there and Atlanta games at eight. So with a win. It'll be ringing in 23 in a crazy way. Something wouldn't have been something it would be something there six and a half. I think they're six and a half point underdogs. And if they lose that we're just in Atlanta for New Year's Eve which we've never done. And then we'll come home on New Year's Day in the morning and maybe go watch the Ravens play the Steelers that afternoon you know
all right let a Raskin is more than that. His son is in Ohio State he sounds like he's a rising freshman but he's almost does the end in the beginning at this point on it and you think you have a chance for national champion for the for the Ravens. You went to the game Sunday. This horrible obviously the situation with Lamar and I watched John Harbaugh's press conference on Monday. He looked almost ashen to some degree, like he's gonna get out there and say maybe this week, maybe next week can be maybe next week and then it'd be maybe the VA, but it starts to feel like this. This is a couple of games that they're gonna have to do something that they couldn't do last year, which is win without him.
Look, look we've spoken this whole year before the season. During the season. What did we talk about?
primary business, the American having insurance,
I hope Lamar had his body has his body insured because every day that guaranteed contract looks worse and worse. And God forbid the knee is real serious bad. It's he's a running quarterback. And this wasn't even on a run. This was on a sack. He wasn't even running. He got hurt trying to be pocket quarterback and he got plowed. He came down on his knee and I don't know what happened but the bruise is obviously more than a bruise. So I think they said the X rays were negative, right?
Yeah, they can say whatever they say who cares? He's razor negative x ray. Oh, it's any Pittsburghers? Not right?
They don't show ligaments right x ray show Bones. So he didn't crack a bone in his knee. But that doesn't mean it didn't tear the ACL or something. PCL is
what a few internet doctors had talked about, which could be a couple, two to four weeks, but it's just different when you're running quarterback and you can't really run and watching Russell Wilson run around the other day, who is a little bit of a shadow. Maybe he's lost a half a step. But if that's your game, if your game speed and you lose a quarter of a step, at that level,
you're normal. You're caught. You're normal. And look Huntley came in kid did all right, but he woke up thinking he was on the practice squad or something. He didn't wake up thinking he was playing Denver's defense. And I don't know whether our offense looked that bad or Denver's defense looked that good but they look really good. Defense looks really good.
They did a bad job, you know. And, but but the issue for this franchise right now is eight and four not unlike last year. Good start Great. Starting four is a great start. It's not a good start to great. It's the foundation to get you into the playoffs. And at the beginning of the year. We were like oh let's start the year against the Giants. The dolphins the Jets. Right and then when CDs enter the year we'll get clear what's not clear what anymore and our quarterbacks gonna go to jail and and the Steelers don't have a quarterback and Mitch Trubisky and all that. And all of a sudden what we have here is four out of five weeks of Division football. Got to begin on the road, the last one on the road in Cincinnati, and all of a sudden
could be a Sunday night game or something wild. If it matters, the easy
schedule has turned into a schedule. We got to go to Pittsburgh and we don't have our left tackle and we don't have our quarterback and we got to go to Cleveland and they're gonna have their quarterback and it's the weather and bla bla bla bla i This. This doesn't have good good mojo right now. Especially if you saw Cincinnati played four o'clock on Sunday.
Absolutely. They beat the chef's they look good against the chef's once more they're three and against the chef's is late last year. How about that?
It's like a big game for
the Super Bowl. He's the only quarterback to beat. Patrick mahomes Three times. Ever, ever. How about that? He's got him three and out.
Well, I had a hard time there. We've had a hard time because we've never really been the better team against the chiefs. Right? And as composed right now. I look at Buffalo I look at Kansas City. I look at Cincinnati and saying how are you going to be two or three of those teams in January as complex as they are right
now as they are now right composition and what happened with Patrick queen?
Well, that was it. That's a bone bruise that was when that is what it is. Calling it a bone bruise. They're calling that a bone bruise and that he'd be able to play at some and what about Hamilton? That that he's in and out i but he's
just I think the kids are stunned but with him out that's not they weren't good when he was out the last. Um, that hurt. That hurt.
I think they start taking pieces away from the secondary pieces away from the pass rush. That's concerning. The biggest concerning thing I have is how they're going to manufacture points. They weren't great with Lamar in there prior to last week. The left tackle situation obviously this kid for lay lay. That's not That's not a winning scenario experiment now.
It's it's a must do. It's a must do but not a great, great experiment. So that's going to be tough. And we got to hope Lamar is sooner rather than later. Although I'll tell you you know Huntleys not bad. He plays a good second. Second, Lamar. He's got he's got some good legs. It looks like it's decent arm. He looked good last year for what he needed to do. But they have to win big games. And the first one is the Steelers I think pick it right Pickett who is coming on. But and if your defense is in hot oh pill, take them apart. Well, the question
is how long Lamar is going to be out and right standard this injury and what it means to them over 234 weeks, like these next three weeks critical may hang in Pittsburgh, maybe hanging in Cleveland, certainly Atlanta looks to be not so good. Now they're gonna play that Cleveland game on Saturday. So the Cleveland game is going to be the short rest right? So getting more back a day earlier. I don't know if a day matters one way or another. But these next two games were the Hatfields and McCoys and the division itself and these rivalry games. This just doesn't it doesn't feel like good mojo to me right now.
Yeah, it's not pretty. And they're gonna have to figure it out and and work through it. You're right. It's gonna be a tough, a tough sled. They're gonna have to pull it. And so we'll see what they're made of. I think that's the big thing. And there's talk in the streets that Greg Roman is being talked to by Stanford.
That's correct. Yeah. So it's been confirmed by John. Right. So
if he goes, if they offer and he goes, You can't get there soon enough to start recruiting.
Well, I don't know about that. I don't know that. That's the way John would see it in regard to play calling. Although calling the play for the wide receiver to throw the football when you're, oh, it feel gold position. I mean, you know, hardball addressed it at length on Monday once he calmed down after the game. He looked a little morose on Monday, given Lamar circumstances and whatever the prognosis is for him, which is he playing in Pittsburgh this week, we get the notion that Greg Roman would call that play, and you know, the chain of command goes I mean, I cannot imagine that play. is installed in that circumstance without John hardball knowing about it. And say, this is a good time to run that or no, no, no, no, no timeout. We're not running that play. We got to get three points here. But John thinks about three points John's
777. And they and you know that played it look right from the start. Right at the snap the way the first hand off happened didn't look right. And then the second one and I'm thinking cool crochets coming around the end, they're gonna they're gonna do it and around the room. Did you see how much field he had in front of them? The dude had room to run. You know why? Because seven guys were in the endzone covering one receiver. Oh, my God.
Well, I mean, I've always said he probably should have ran with the ball, you know, like,
so much room. And then after that, right after he threw it, and they picked it, I said to the people that we sit with and sit around us I said, is your third string quarterback? Because he's a runner, and what have Huntley would have gone down who's, who's next up is
Sam Cooke used to be the guy he's not here and not here. Now. I'll
tell you what, the one thing I'll say other than the misery of the game, which it was miserable, except we got the W so I guess I'll take miserable in a win versus Jacksonville. And look at okay, and losing, you know, that's okay. But but the halftime was really good, really strong. I had not seen Marshall yonder in quite a while. That man is half the man he used to be. My God. The man was almost unrecognizable, the amount of weight that was off his shell. And just great words, really, really smooth. really caring. And, boy, he sounded like he wanted to be out there and play and he was fired up. For Baltimore fired up for football. I don't know what he's doing these days. But that man wants to coach. He was rah, rah rollin baby. He was ready to coach up the line.
lost all the weight before the plague right so he retired after the 19 season. Yeah, brought everybody back and we were all like for him to retire. We were like what happened in March? He lost all that weight like instantly first one.
It was a it's amazing. The demand looks it was all dressed up in a suit. Yeah, just kids his wife there. He's looking sharp. And he was talking some smack that dude was ready. I'm telling you. He sounded ready to coach it offense. He sounded ready to coach Ray Lewis. That dude was ready to bang through a wall for the Ravens. Yes,
sponsor me a number of years but he came out and did the show with me. I want to say was in 1716 or 17. Yeah, it was after Jen survive. We swapped for the bone marrow registry. We did it up in Carroll County at Greenmount station where you can now legally play some sports wagers games if you wish. I didn't get a great crabcake as well. It's good ribs to Chris up their agreement. So I ran the interview with him on Monday here at AM 15 Seven eat again on Tuesday morning this week and I you know I put it up because it's been six seven years right? I've known Marshall getting ya know his mother the first time you ever gotten a game. We kicked off the season in Cincinnati was a night game back in 2006 when he was drafted I was sitting in the stands in the upper deck. His mother was sitting near me and her boy was going into an NFL game for the first time and they were an Iowa farm fire.
He's a farmer. He's a farmer.
So that's how far back I add this picture Marshall and we both look young, you know in in 2006. So Marshall came out and did the show. And all I remember about that night and I haven't listened to the interview even though we ran it on Monday was I remember sitting with him and he was always one that didn't like the media so much whatever. He got along fine with me but he didn't do a lot of things. It's one of the reasons you'd like to speak all them. That's right. That's right. Isn't rude to the media. He very puffy didn't seek the spotlight. Right? It is so he said them to us that and that he kind of confide in and we got we got a really loose version of Marshall that night. You know I got I got a lot out of him which I think is my gift as an interviewer. And I remember him saying I hate lazy I hate I hate everything. I know that I can't stand more than lazy and I'm thinking No wonder you and I get along. There's a story of like, lazy more than me, you know? So I found that that that is that's the heart of Marshall yonder. That's absolutely a Hall of Famer quick
for you didn't hear his I agree if you didn't hear his interview from Sunday, but not as interview his halftime talk from Sunday. Get it? It's got to be on YouTube. It had to be recorded. Just it was five minutes, two minutes, but it was strong. Dude was strong. It was a three Hall of Fame speech is what you're saying. And he's got that Bill coward chin, he's chiseled now his face he's got that chin going. It's got that cower chin he bring him back and Evan Dr. Jeff Saturday when you fire hardball is lettering not finding the head coaching as easy as he thought it might be.
Raskin global is the way to find letter. He manages money as well as I don't give you a little love. You know you've had a nice year you've traveled a lot. You've taken care of your money, your wealth. This is a time where your wife's healthy your son's health. He's in college ran around Europe all summer. You're doing a little bit of beachy time here. But like as you go away and you have hundreds of clients, most important thing people need to be thinking about at the end of the year because I asked you this every week and I'm thinking not everybody listens to everything every week. Yeah sure to say my end the year in handling your money is important.
Yeah, well, here's the thing. There are a couple of things. If you're going to do any charity, do it, give to charities, or get prepared to give to charity. If you're a business owner, you want to make sure that your income and expenses are scheduled in the right year. You may want to stop billing people to stop getting in revenue before your end and have to pay taxes on it delay that till next year. Or if you're not having a great year you might want to pull some income into this year and bring more in it might be in a lower tax bracket. So you got to do your year end planning and this is the time beginning of December. You don't want to wait till the 27th to go. We need to do know right around now the beginning of the month you take a look you get with your advisors, you get with your team of people and you make sure you're doing the right thing. If you're not a business owner, make sure if you wanted to put money into 401k that you got in there what you wanted to get in there. If you work at a company you're looking for a Christmas bonus a holiday bonus and you're not sure whether or not they're going to contribute to your 401 k out of your bonus. If you want it contributed make sure it comes out if you don't want to contribute and make sure it's turned off. These are just the year end kind of things you need to touch on check on and most importantly I would say get yourself organized. Get ready for 23 It's coming fast. I was with I was with a POW at the game Sunday. So as you said had a colleague in from out of town. And interesting Quick, quick aside. He said something resonated when he said it he said as you get older I hadn't heard this saying before but it was I've heard like it but he said you wrote it down is what you're telling me? No I didn't write it down but it's in here. He said he said somebody told him once. Somebody told him once that as you get older Life is like a roll of toilet paper. And it just goes faster and faster and faster as you get older.
I'm not gonna write that one down.
It's kind of a profound thing. So fact is you got to think about it. You know, as I get older, there's less toilet paper on the roll and that's the point on the roll right but it pulls faster pulls faster. So his point was as you get older the years seem to go by a lot faster. So you gotta get ready for 23 Because we're you know, it's 24 and it just, it just goes back and he's he's a he was a big Buckeye fan and and we were both kind of pretty happy that playoffs were coming for for the suns Buckeye and get to go all the way to a playoff football and the Buckeye ladies are in the sweet 16 I think it is of the volleyball national tournament so that's kind of cool. The boys been playing the band everywhere. And he's got another five days of school and then finals. And then like you said, Man, it was like he was a rising freshman and now he's finished it up as junior almost year it's crazy. But yeah, get yourself organized for 23 it comes out you're fast. Be ready. Make sure you're doing what you need to be doing.
All right, let us know what do you need to be doing a joint itself here this week? Get ready for the holidays. You can reach him at Raskin global.com See and my year Leonard has during the course of this year, we've gotten entangled with each other he's been trying to help me out of all sorts of little not a mess, but angleman I'm not a mess. So I'll at least say that much you can find him out of rescue global and of course in the front, a Baltimore positive that can last thing for you. All right. crabcakes we're gonna be down a fade. He's talking about shipping. You're gonna be cautious next week shipping crabcakes you know, and I know you're a guy who's a generous guy. You get a lot of people out of town. You were over you said to me last week I'm gonna go get some crabs. I'm gonna go to cost us after the game. How were the crabs? That's the
dude. Dude. It's amazing. We're in December. We're in December.
Your parents told you couldn't get crabs in December, right?
We lied about that. It's December. I hit you up. I said hey, where? Where would you go? Out to eat because we we bring crabs in the house all year round. We bring them home all the time. But we wanted to take this guy out for a Baltimore crab experience. He never had steamed crabs. So we said never have add on guy he got in he got in Saturday. He got into Saturday evening. We went to Pappas for crabcakes. Saturday night he had a crab cake. He said it was phenomenally never had anything like it in his life. So I said to him Sunday we're going to tailgate. We're going to go to the football game. And then we're going out to figure out how they pull the meat to put in those crab cakes. So you said go to cost us man go to cost us they'll take care of you. So we went out to cost us and it was fantastic. We got a little crab soup. We got a little appetizer because I always feel like when you're a first time or when you're that crab picking virgin. You need some side food while you're picking because you're not really going to get all the crap out and you don't know how to do this. You might not be happy doing it. This guy said look, I've been to crawfish boils. I've been to lobster bakes. I've eaten oysters like they're going out of style ease and you just put it in front of me and teach me how to do it. This is a guy that went to Air Force The Air Force Academy and you'll you'll appreciate this. I'll tell you this little quick story. He he informed me and the wife that he was first team all I don't know if it was packed. Where's the Air Force Academy? The whack the pack? Whatever they were wack for a while. Yeah. So he was first team all conference wide receiver ahead of Steve Smith seen.
Oh, Utah was in that conference. Of course ABS Yes.
Yes, he said they were friends. They hung out. He went to the academy. Steve Smith went to the the Panthers. And he went to fly jets. There you go. Anyway, you eventually and and he learned last weekend he learned how to crack crabs. He learned how to pull those things apart. Dig into that meet and he was he was in heaven. The dude was in heaven. So we we ate crabs, drank some beer. And then I said this is me. I don't know how everybody else does it. But for me. When you finish up your crab feast you need to have vanilla ice cream. That's how you finish it. The only one that's ever said that to me that's how you finish it right so we got
a lot of people in Baltimore telling me they finished grabs.
We got vanilla hot fudge sundaes with the wet nuts and the whipped cream. And and we ate like we were going to the chair and the food was fantastic. The bill was just right my friend. Everything was fantastic. We have a few crabs leftover which the wife and I chose to imbibe following and it's all good. It's all good.
Well, you know, every time we get the whole thing started with that video with three and a half million views on how to pick a crab the right way. It all started with Moeller and I doubt it fails one day when this young lady was in from Minnesota and she had never seen a crab and didn't really even know where to begin. And I keep thinking to myself the intimidation factor. Like when you see that, that that crush file that you just sit there and you're like what what do I do with it it's
out of it you know pile on paper you go what and and so he cracked the first one he opens it up and he goes alright can eat this I said no, no, no way. way way way way. You don't eat that stuff on the outside there. You don't eat that stuff. That's that's not good. It's like that
Bob Seger song against the wind what to leave in what to leave out. You don't know what to eat when you're not appreciative all we had a great week and I hope this Pittsburgh week your thing goes better than we think it's gonna go. So we'll see you on the other side of your vacay before Christmas, Hanukkah a hot new years. Absolutely. Oh we got all tax situations we get all that stuff happen.
Let a flex to Cleveland Browns game. Saturday like
25:20 Saturday afternoon Cleveland Browns right. And then Christmas Eve against the Atlanta Falcons. So have that. You can find Leonard at Raskin global.com To get all sorts of wisdom, ideas about money and protecting yourself and insurance and doing the right thing keep your money away from the government. And but that's a rescue global.com Please do that. You can also check out letter at the front of Baltimore positive.com We're doing the Maryland crab cake tour Friday at Bally's show brought to you by our friends at the Maryland lottery with goodwill and when donation we're getting back after the rock and roll thing next Thursday for my 31st anniversary. 31 years on radio. There you go next week. It's crazy next Tuesday I have to go find Kenny Albert as well. We are wn st am 1570 Towson, Baltimore and we never stop talking Baltimore positive
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Maryland Crab Cake (and Brewery) Tour Day 20: Once you go, you know
Morgan Moses says Ravens-Steelers rivalry "sticks out way more" than others in which he's taken part
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With changes looming elsewhere, Ravens hope to keep offensive line largely intact
A source of frustration in the previous two seasons, the offensive line was among the NFL's best in 2022.
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#ColumnNes
Nestor Aparicio -
After 26 faithful purple seasons, the Ravens have bullied me out of my seats and denied my media access
This is my story. This is the truth. And it must be told. In its entirety because it's so outrageous as to be almost unbelievable. Covering the Ravens is all I've ever done professionally since the team arrived in Baltimore in 1996, and this is how I feed my family and pay my bills as a small local business and AM 1570 radio operator and entrepreneur.
#ColumnNes Regarding Lamar Jackson, the lack of maturity is a bigger issue than an ugly tweet
If Lamar Jackson regrets the statement to the fellow in Pennsylvania, he should've offered an apology to him. If he regrets the world seeing his ugly words, Jackson has a platform with a million followers and could've offered an apology. If it was truly "out of character," then show your character and admit a mistake and move on.
Why did Chad Steele take my press credentials after 26 years of covering the Baltimore Ravens?
This is my story in my own words. Listen and learn about how the NFL treats the local media and avoids the tough questions and intimidates local media who have traveled and reported on Baltimore football since before Art Modell brought the Ravens here in 1995. What happened is wrong and here's why...
Luke Jones and Nestor discuss Ravens offensive coordinator opening and future at QB for Harbaugh
Luke Jones and Nestor get ready for Eagles and Chiefs in battle of the best of NFL
Sam Sessa and Jimi Haha tell Nestor about bringing kids to Annapolis to see Jimmie's Chicken Shack
John Martin of Maryland Lottery discusses kickoff of 50th Anniversary celebration and big winners
Bruce Posner joins Nestor to discuss Terps hoops and lacrosse & all things Lamar Jackson and Ravens
Longtime sports PR man Chip Namias shares some Love Ya Blue magic and memories with Nestor
Bill Cole and Nestor discuss how Ravens fans would react to a Lamar Jackson trade
Allen McCallum and Nestor Aparicio convene three decades later looking for Angelos family legacy
Dennis Curtin and Nestor discuss snacks and strategies for Super Bowl weekend and stocking the party
Longtime sports exec and Baltimorean David Katz gives Nestor his Lamar Jackson timeline
Comedian Tommy Davidson talks smooth jazz and the living color of comedy and Maryland roots
Dennis Koulatsos and Nestor discuss why they believe Lamar Jackson and Ravens will part ways
Leonard Raskin and Nestor discuss fans understanding the business of football and money of Lamar
Luke Jones and Nestor assess Ravens circumstances and options with Lamar Jackson this offseason
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Visionary Rebecca Hoffberger shares her vision for the future of Baltimore prosperity with Nestor
John Martin of Maryland Lottery tells Nestor about aftermath of hitting the big one in Mega Millions
Bill Cole and Nestor discuss disappointments of Ravens and Lamar Jackson football relationship
Thom Loverro of The Washington Times joins Nestor to discuss the angry words of John Angelos
Mike Rosenfeld takes Nestor on amazing journey through the power of Artificial Intelligence
Nestor Aparicio breaks out purple crystal ball to discuss Ravens offseason with Dennis Koulatsos
Luke Jones prepares Dennis Koulatsos for all that happens for Ravens after Greg Roman era
Telling the G&A Restaurant and hot dog story from Highlandtown to White Marsh with Andy Farantos
Dennis Koulatsos and Nestor believe the Lamar Jackson era has ended in Baltimore
Longtime WJZ reporter Mike Schuh tells Nestor about storytelling gig that has shown him the world
Leonard Raskin and Nestor lament the end of Ravens season and wonder what is ahead for Lamar Jackson
Our Honeygo Weis Markets manager Nick Fischer retuns with an eggceptional offer and local history
Luke Jones and Nestor clean out the lockers of Ravens and wonder about future of Lamar and franchise
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Luke Jones gets you ready for the Cincinnati Bengals and what comes after the season ends
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Authors James Patterson and Mike Lupica give Nestor lesson in writing and unveil The House of Wolves
Paul Dehner of The Athletic tells Nestor how Joe Burrow has changed everything in Cincinnati
Bill Cole and Nestor discuss the most unusual Festivus in annals of Baltimore football history
John Martin of Maryland Lottery gives Nestor details on the almost historic Mega Millions jackpot
Solomon Wilcots tells Nestor about The Jungle waiting for Ravens in playoff mad Cincinnati on Sunday
Jason Cole of Outkick joins Nestor to discuss all things Lamar Jackson, contract, health and future
Chris Pika of Blog And Tackle joins Nestor to discuss NFL managing crisis and Ravens handling Lamar
Quintin Dailey of Planet Fitness gets Nestor motivated for a new year of health and wellness locally
Leonard Raskin and Nestor discuss Ravens world waiting on Lamar Jackson to save January
Dennis Koulatsos and Nestor discuss playoff consequences for Ravens and Lamar Jackson
Luke Jones and Nestor go down the playoff road and Ravens path in crowded AFC field for Super Bowl
Luke Jones and Nestor discuss playoff mystery week around Lamar Jackson and beating Bengals
Luke Jones tells Dennis Koulatsos realities of Ravens situation headed to Cincinnati before playoffs
Nestor Aparicio joins Dennis Koulatsos to preview Bengals & Ravens and NFL show goes on after Hamlin
Neil deMause of Field of Schemes joins Nestor to discuss realities of a free $600 million for Ravens
John Martin of Maryland Lottery welcomes New Year with new games and 50th Anniversary mojo
Podcasts Now
Maryland Crab Cake Tour
Hot dogs and crab cakes with Andy
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Telling the G&A Restaurant family story from Highlandtown to White Marsh with Andy Farantos. And, yes, french fries and gravy were on the menu!
Putting the Schuh on other foot and interviewing the longtime WJZ reporter
Longtime WJZ reporter Mike Schuh tells Nestor about his new storytelling gig that has shown him new places and the Northern Lights after 27 years in Baltimore on TV Hill.
An eggceptional deal for Weis Rewards members
Business Baltimore Positive - January 17, 2023
Our resident Honeygo Weis Markets manager Nick Fischer returns with an eggceptional offer and more curious local history with his passion for old bottles and glass.
Maryland Crab Cake (and Brewery) Tour Day 23: Black Flag in Columbia and the delicious Timbuktu experience
The 23rd day of the Maryland Crab Cake Tour presented by The Maryland Lottery, Goodwill, Window Nation and the Restaurant Association of Maryland took us to a place we hadn't been in many years – Timbuktu in Elkridge en route to see Duran Duran at Merriweather Post Pavilion. Nile Rodgers stole the show but Timbuktu can stick those pimentos in my 'cake anytime.
Let's learn about the modern Enoch Pratt Free Library in Highlandtown
The Maryland Crab Cake Tour seeks knowledge. Along with Councilman Zeke Cohen, Nestor is joined by Heidi Daniel of Baltimore's library system to discuss Frank Zappa, kids and their parents getting online and why you need to come back to the library. And maybe even pay that fine from the 1980s...
1st Maryland Crab Cake Tour: Day 25 Heading west and seeing the mountainous beauty of our state
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Finding wellness and care at SoBotanical in Fed Hill
The Maryland Crab Cake Tour presented by the Maryland Lottery featured all women, small business owners at an impromptu stop at Mother's in Federal Hill. Hear the stories of SoBotanical owner Theresa Cangialosi and Live Baltimore founder and cancer survivor Tracy Gosson as part of our Friday conversations.
Dundalk's Rock And Roll Hall of Fame Queen tells us there is only one home for the holidays
Legendary drummer Gina Schock of The Go-Go's returns to the Maryland Crab Cake Tour for Nestor's 31st Anniversary at Costas Inn in Dundalk with pals John Allen and former 1970s bandmate George Kondylas to tell old punk rock Christmas tales of yore.
—Weis Conversations
Luke Jones and Nestor discuss the outburst, deflection and lies of John Angelos and the mostly quiet Orioles offseason and winter of hope on the field.
Davidson brings his smooth jazz, comedy and soul back home to Maryland this weekend at Baltimore Comedy Factory
Comedian and Silver Spring native Tommy Davidson talks about his smooth jazz collaboration with Dave Koz and the living color of comedy and why his Maryland roots remain deep.
Separating facts from fiction: Lamar Jackson v. Ravens for the money has begun
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Burrowing in for another unlikely Super Bowl run?
Luke Jones and Nestor assess the wreckage of the Buffalo Bills and who is going to Super Bowl LVII in Glendale? Great AFC and NFC Championship Games ahead on Sunday.
Waiting for John Angelos to show us the financials of the Baltimore Orioles
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A purple and orange local sports poet – and we didn't even know it?
Our Chief Digital Officer Mike Rosenfeld of Web Connection takes Nestor on amazing journey through the power of Artificial Intelligence and the power of AI technology.
How will Lamar Jackson negotiate his best deal?
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Reimagining a new, beautiful Inner Harbor for our children
Visionary Rebecca Hoffberger shares her vision for the future of Baltimore prosperity with Nestor. Big thanks to The Baltimore Fishbowl for this inspired story and TBC for this amazing image.
What comes after you hit the big one?
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If Ravens and Lamar divorce, what will they tell the fans?
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Who will be willing to pay Lamar the most – and pay the most for Lamar?
Leonard Raskin and Nestor lament the end of Ravens season and wonder what is ahead for Number 8 and his agent and Steve Bisciotti and Eric DeCosta.
Luke Jones and Nestor clean out the lockers of Ravens and wonder in long form about every aspect of the cloudy future of Lamar Jackson and the disengagement with the franchise.
Picking up the pieces of another lost season with Lamar Jackson
As conjecture and grandstanding about the future of the quarterback position begins, Luke Jones and Nestor pick up the pieces of another lost Ravens season with Lamar Jackson unable to play football after Thanksgiving.
The end of the road for Lamar Jackson in Baltimore?
The bitter end of up coming close
Luke Jones joins Nestor to break down how Ravens lost to Bengals to exit playoffs and what happens next for the franchise with so many changes coming.
Finding new ways to play
So what exactly will Steve Bisciotti be doing with $600 million of free money from your tax dollars?
Longtime stadium and civic money observer Neil deMause of Field of Schemes joins Nestor to discuss the realities of free money for Steve Bisciotti and The Angelos Family via Annapolis in the bonds that were created last year.
#DearOrioles Baltimore Positive - January 24, 2023
Bill Cole Baltimore Positive - January 24, 2023
The 28-year-old made 30 starts in 2022, posting a career-best 3.98 ERA.
WNST Baltimore Positive -
Center Tyler Linderbaum played more snaps than any other Baltimore rookie this season.
@BaltimoreLuke
Luke Jones and Nestor react to the scene in Cincinnati after Damar Hamlin injury and impact on NFL
The WNST Sports Report
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Luke Jones WNST Baltimore Positive - January 25, 2023
Two Ravens players voted to 2022 PFWA All-Rookie team
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Preparing for life after Greg Roman
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Twelve Ravens Thoughts following season-ending press conference
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Ronnie Stanley on Lamar Jackson: "In my mind, I know he's going to be here"
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#RavensFlock
Good Sports
Dennis Koulatsos
Bill Cole


If you've enjoyed the YMCA experience in your hometown or here in Las Vegas, you may find a Y career or volunteer position rewarding. If you can relate to our four core values of caring, honesty, respect and responsibility, keep reading.
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Personal responsibility and accountability are key to any Y employee's success, as staff lead by example, motivate and inspire others. Our employees don't simply work at the Y, they live, love and promote healthy lifestyles.
Can you see yourself as part of the nation's leading nonprofit for youth development, healthy living and social responsibility? If you're up for the challenges and rewards that come with working at the Y, check our openings regularly. Lifeguards, instructors, coaches, customer service representatives and program directors are among the many opportunities that become available.
Fun Fact: Celebrities and athletes, including Tony Hawk, Lennox Lewis, John Lennon and Britney Spears, among many others, spent time at the YMCA. You never know who you'll run into on the job!


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Attention: The internal data of table "166" is corrupted!
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text:
Q: Residue for $\frac{\zeta(s)}{\zeta(2s)}$ at zeros of $\zeta(2s).$ I want to calculate residue at the poles for $\frac{\zeta(s)}{\zeta(2s)}.$ For pole of numerator $s=1$ I have calculated the residue. I am having trouble at the zeros of denominator. Basically I am interested in this limit
$$ Res_{s= \frac{1}{2}\rho}\frac{\zeta(s)}{\zeta(2s)} = \lim_{s\to \frac{1}{2}\rho } \frac{(s- \frac{1}{2}\rho )\zeta(s)}{\zeta(2s)}  $$
where $\rho$ are the non-trivial zeros of $\zeta(s).$
Any help will be appreciated. Thanks.

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