Scott A. Hagen, M.D.; Amy L. Kondyra, B.A.; Hilary P. Grocott, M.D.; Habib El-Moalem, Ph.D.; Daniel Bainbridge, M.D.; et al Joseph P. Mathew, M.D.; Mark F. Newman, M.D.; Joseph G. Reves, M.D.; Debra A. Schwinn, M.D.; Madan M. Kwatra, Ph.D.
* Fellow, Pediatric Critical Care Medicine, Duke University Medical Center, Durham, North Carolina. † Graduate Student, Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania. ‡ Associate Professor, § Fellow, ∥ Professor and # Chairman, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina. ** Vice President for Medical Affairs and Dean, College of Medicine, Medical University of South Carolina, Charleston, South Carolina.
The IL-6 can contribute to cellular injury by several mechanisms, including upregulation of adhesion molecules on endothelium and neutrophils, as well as expression of inducible nitric oxide. 14–17 A recent study links increased plasma IL-6 with a dysfunction in the regulation of G protein–coupled receptors (GPCRs) in peripheral blood mononuclear cells. 18 This study demonstrated that patients with rheumatoid arthritis have decreased concentrations of G protein–coupled receptor kinases (GRKs), a family of six isozymes numbered GRK1 to GRK6, in their mononuclear cells. The decrease was attributed to IL-6 because mononuclear cells from healthy donors, when exposed to IL-6, showed a decrease in GRK2 expression. 18 These data indicate that IL-6, which is synthesized in mononuclear cells, has mononuclear cells as one of its targets. The effect of IL-6 on GRKs is likely to be important because these kinases play a key regulatory role in the desensitization or attenuation of signaling through GPCRs, including GPCRs for substance P, IL-8, and chemokines that are known to cause inflammation. 19,20 Since IL-6 is increased during CPB, we sought to determine whether GRKs in peripheral blood mononuclear cells are affected by CPB.
After written informed consent was obtained, fifteen patients were enrolled in this study approved by the Institutional Review Board. The patients underwent surgery involving CPB and were enrolled successively without exclusions for patient condition or type of surgery. Blood samples (15 ml) were collected in EDTA-coated tubes at the following times: before surgery (PRE), 2 h after completion of CPB (POST), and 24 h after completion of CPB (POD1). Samples were transported to the laboratory at room temperature. Patient records were reviewed to gather demographic data, preoperative diagnosis, surgical procedure, length of CPB, length of hospital stay, and postoperative complications.
An 800 μl portion of each sample was centrifuged at 1500 ×g to obtain plasma used for the IL-6 assay. The remaining blood was used to isolate peripheral blood mononuclear cells over Ficoll-Hypaque Histopaque® (Sigma, St. Louis, MO) density gradients, as described by Böyum. 21 Mononuclear cells and plasma were stored at −80°C until used.
Mononuclear cells were thawed, then suspended in 0.5–1.0 ml of ice-cold buffer A (20 mm Tris-HCl [pH 7.4], 2 mm EDTA, containing the protease inhibitors 100 μm PMSF, 10 μg/ml leupeptin, 5 μg/ml aprotinin, 10 μg/ml soybean trypsin inhibitor, 150 μg/ml benzamidine); homogenized using a hand-held tissue disruptor on low speed; and centrifuged at 4°C at 45,000 g for 15 min. The supernatant, representing the cytosolic fraction, was stored at −80°C until analysis. The membrane pellet was resuspended in 0.5 ml buffer A and stored at −80°C.
The concentration of plasma IL-6 was determined by enzyme-linked immunosorbent assay using a commercially available kit following the manufacturer instructions (Quantikine HS, R&D Systems, Minneapolis, MN).
The GRK activity in the cytosolic fraction was assessed using light-dependent phosphorylation of rhodopsin in urea-washed bovine rod outer segments (ROS), as described previously. 22,23 Briefly, 6 μg of cytosolic protein from mononuclear cells and 5 μg of ROS proteins were suspended in a total volume of 50 μl consisting of 20 mm Tris-HCl (pH 7.4), 10 mm MgCl2, 2 mm EDTA, and [γ-32P] adenosine triphosphate (final concentration 100 μm, specific activity 2–4 cpm/fmol). The reaction was allowed to proceed for 5 min at 30°C and was then stopped by adding 50 μl of sample buffer (25 mm Tris-HCl [pH 6.8], 10% glycerol, 8% sodium dodecyl sulfate, 0.0125% Bromophenol Blue). Phosphorylated rhodopsin was separated by electrophoresis on 10% sodium dodecyl sulfate–polyacrylamide gels (SDS-PAGE), and visualized by autoradiography. The rhodopsin band was excised from the dried gels and counted by liquid scintillation spectroscopy. Background phosphorylation was determined by performing phosphorylation of rhodopsin in the absence of mononuclear cell cytosol, and 32P incorporated into rhodopsin was subtracted from 32P incorporated into rhodopsin in the presence of mononuclear cell cytosol. Results are expressed as fmol 32P incorporated into rhodopsin · minute−1·μg cytosolic protein−1, and as a percentage of baseline (PRE) activity.
The GRK activity and protein expression for each subject are reported as a percentage of PRE levels and expressed as mean ± SD. An exact Wilcoxon signed rank test or paired t test was used to study change in GRKs and IL-6 values between PRE, POST and POD1 samples; we applied the Bonferroni correction to these changes and a P value of less than 0.0167 was considered significant for these tests. The relationship between these measured variables were determined using exact tests of Kendall τ b correlations, simple multiple linear regression, and separate mixed models. A P value of less than 0.05 was considered significant for these tests. Data were analyzed using SAS software (SAS, Cary, NC) and STATXACT (Boston, MA) software.
Table 1presents patient demographic data, surgical procedure, length of CPB, length of postoperative hospital stay and postoperative complications.
Plasma IL-6 increased more than 20-fold after CPB from 2.9 to 62.0 pg/mL (P < 0.0001) and remained increased to 88.6 pg/mL on POD1 (P < 0.0001) (fig. 1).
Fig. 1. Effect of cardiopulmonary bypass (CPB) on plasma interleukin (IL)-6 (n = 11). Plasma IL-6 was measured as described in the methods section. The increase in IL-6 from PRE to POST and POD1 samples was statistically significant (*P < 0.0001). The increase in IL-6 from POST to POD1 did not reach statistical significance (†P = 0.035). PRE = before surgery; POST = 2 h after completion of CPB; POD1 = 24 h after completion of CPB.
Figure 2Ashows that rhodopsin phosphorylation, which represents GRK activity, 26,27 decreased substantially in the POST sample and remains low in the POD1 sample. Average kinase activity in PRE samples was 7.5 ± 3.5 fmol 32P incorporated into rhodopsin · minute−1·μg cytosolic protein−1, and it decreased by 39 ± 29% after CPB (P = 0.0014). The CPB-induced decrease in GRK activity was seen in all but one patient, but the recovery was quite variable among patients (fig. 2B).
Fig. 2. Effect of cardiopulmonary bypass (CPB) on G protein–coupled receptor kinase (GRK) activity in mononuclear cells (n = 15). (A ) Autoradiogram from patient 10 showing GRK activity in cytosolic fraction of mononuclear cells as measured by phosphorylation of rhodopsin in urea-washed bovine rod outer segment (ROS). Lane 1, phosphorylation of ROS with purified recombinant GRK2; lane 2, phoshorylation of ROS in the absence of cytosolic mononuclear cell fraction; lane 3, phosphorylation of ROS with pre-CPB cytosol (PRE); lane 4, phosphorylation of ROS with post-CPB cytosol (POST); lane 5, phosphorylation of ROS with postoperative day 1 (POD1) cytosol. (B ) The GRK activity (as a percent of PRE) in POST and POD1 samples from individual patients. The numbers on the right correspond to patient numbers shown in table 1.
We determined whether the observed decrease in GRK activity after CPB was due to a decrease in GRK2 protein. Figure 3shows that cytosolic GRK2 expression decreased dramatically after CPB by 90 ± 15% (P = 0.0001), indicating that the decrease in cytosolic GRK activity after CPB could be attributed to a decline in GRK2 protein. The decrease in cytosolic GRK2 was not due to GRK2 translocation to membrane because membrane-associated GRK2 was also significantly decreased after CPB by 78 ± 27% (P = 0.002, data not shown). It should be pointed out that the decrease in GRK2 protein in POST samples (fig. 3B) was much greater than the decrease in GRK activity (fig. 2B). The disparity between measured GRK activity in the cytosol and the expression of GRK2 protein in the cytosol indicates that other kinases contribute to the phosphorylation of rhodopsin.
Fig. 3. Effect of cardiopulmonary bypass (CPB) on GRK2 protein in mononuclear cell cytosol (n = 15). (A ) GRK2 immunoreactivity in mononuclear cell cytosol from patients 7 and 4. The immunoblotting was carried out as described in the methods section. GRK2 lane, 100 ng of purified GRK2; PRE lanes, 30 μg mononuclear cell cytosolic protein from pre-CPB sample; POST lanes, 30 μg mononuclear cell cytosolic protein from post-CPB samples; POD1 lanes, 30 μg mononuclear cell cytosolic protein from POD1 samples. (B ) GRK2 protein expression in POST and POD1 samples from individual patients. Patient numbers are shown to the right. PRE = before surgery; POST = 2 h after completion of CPB; POD1 = 24 h after completion of CPB.
As with GRK activity, the recovery of GRK2 on POD1 differed considerably between patients (fig. 3B).
Fig. 4. Effect of cardiopulmonary bypass (CPB) on Gsα, Giα, and GRK2 in mononuclear cells (n = 3). The Gsα, and Giαimmunoreactivity was determined in mononuclear cell membrane, and GRK2 immunoreactivity was measured in mononuclear cell cytosol in PRE, POST, and POD1 samples from three different patients. The G protein immunoblot utilized 20 μg of membrane protein, and the GRK2 immunoblot utilized 30 μg of cytosolic protein from each sample. The consistent decrease in GRK2 after CPB does not occur in G proteins after CPB, demonstrating that the decrease in GRK2 is not due to a decrease in all proteins associated with the GPCR signaling network. PRE = before surgery; POST = 2 h after completion of CPB; POD1 = 24 h after completion of CPB.
Figure 5shows that membrane-bound GRK6 decreases after CPB and the average decrease in GRK6 is 65 ± 43% from PRE levels (P = 0.0015). As with GRK2 and GRK activity, the recovery of GRK6 on POD1 varied considerably between patients (fig. 5B).
Fig. 5. Effect of cardiopulmonary bypass (CPB) on GRK6 expression in mononuclear cell membranes (n = 12). (A ) GRK6 immunoreactivity in mononuclear cell membranes from patients 3 and 1. The immunoblotting was carried out as described in the methods section. GRK6 lane, 2 μg of recombinant GRK6 in Sf9 membranes; PRE lanes, 30 μg mononuclear cell membrane proteins from pre-CPB sample; POST lanes, 30 μg mononuclear cell membrane protein from post-CPB samples; POD1 lanes, 30 μg mononuclear cell membrane protein from POD1 samples. (B ) The GRK6 protein expression in POST and POD1 samples from individual patients. Patient numbers are shown to the right. PRE = before surgery; POST = 2 h after completion of CPB; POD1 = 24 h after completion of CPB.
A negative correlation between cytosolic GRK activity and plasma IL-6 was detected when a mixed model analysis was performed (P = 0.0017) and a negative correlation was also found between GRK6 expression and IL-6 using simple linear regression (P = 0.0181). However, we did not find a statistically significant correlation between changes in GRK2 expression and plasma IL-6, presumably due to our small sample size.
In this study, we provide the first evidence that cardiac surgery involving CPB decreases GRK activity and expression in peripheral blood mononuclear cells. More importantly, we find that the recovery of GRK activity and expression on POD1 is highly variable among patients, with some patients showing little or no recovery. This finding is interesting because a poor recovery of GRKs after CPB may slow the desensitization of GPCRs on mononuclear cells that propagate inflammation, thus contributing to postoperative morbidity. Testing this possibility would require a larger prospective study.
The main purpose of our study was to determine if the acute increase in IL-6 seen after CPB is associated with a decrease in GRKs in peripheral blood mononuclear cells. We found that the CPB-induced increase in IL-6 had a negative correlation with GRK activity and GRK6 expression. However, our data suggest that while IL-6 may contribute to the observed decrease in GRKs, these kinases recover in many patients on POD1 despite increased concentrations of plasma IL-6. This observation differs from the persistent decrease in GRK2 demonstrated by Lombardi et al. after exposure of mononuclear cells to IL-6 in vitro . 18 It seems that under in vivo conditions, IL-6 may be the mechanism for the initial decrease in GRKs, but its effects are attenuated with time, possibly due to the release of antiinflammatory molecules such as IL-10. 5 It should also be kept in mind that the observed effect on GRKs could be mediated through other cytokines or biomolecules since CPB is known to be accompanied with a profound inflammatory response. 5,6,16,17 Clearly, further studies are needed to delineate the molecular events responsible for the observed decline in GRKs after CPB.
In conclusion, we have demonstrated that CPB is associated with a significant decrease in GRK activity as well as in GRK2 and GRK6 protein expression in mononuclear cells. The significant variability among patients in the decline and recovery of GRKs after CPB should be further investigated as potential markers for the development of postoperative complications. Finally, it should be pointed out that the decline in GRKs seen in mononuclear cells after CPB may or may not occur in other tissues.
The authors thank Yuri Klyachkin (Technician) for technical assistance and Kimberly B. Allison (Secretary) for editorial assistance (both at Department of Anesthesiology, Duke University Medical Center, Durham, NC).
Scott A. Hagen, Amy L. Kondyra, Hilary P. Grocott, Habib El-Moalem, Daniel Bainbridge, Joseph P. Mathew, Mark F. Newman, Joseph G. Reves, Debra A. Schwinn, Madan M. Kwatra; Cardiopulmonary Bypass Decreases G Protein–Coupled Receptor Kinase Activity and Expression in Human Peripheral Blood Mononuclear Cells. Anesthesiology 2003;98(2):343-348. doi: 0000542-200302000-00012.


text:
News | Local
State lawmaker suggests Olmsted County adopt a mask mandate following COVID update
Rep. Liebling encouraged commissioners to take preventive steps as local cases continue to climb.
Rep. Tina Liebling
By Randy Petersen
ROCHESTER — Skyrocketing COVID numbers prompted a state lawmaker to ask Olmsted County commissioners to consider a mask mandate Monday, Jan. 10.
"I would really like to see you impose a mask mandate countywide or take some other steps like that," Rep. Tina Liebling, DFL-Rochester, told commissioners during an online meeting. "I think we're in such a bad situation."
"Music is needed more than ever" now, says teacher Vivian Lark.
By John Sievers / For the Post Bulletin
John Marshall grad Cazz Martin had two standout football seasons at the University of Minnesota Duluth and last week he attended the three-day College Gridiron Showcase in Fort Worth, Texas.
By Guy N. Limbeck
Highlights of events in 1997, 1972, 1947 and 1922.
County commissioners did not respond to the request, and in the past several members of the board have suggested such action is best left to the state.
Later in the day, County Board Chairman Mark Thein said commissioners haven't expressed a desire to change that stance.
"I don't see the board implementing a mask mandate at this time," he said. "We don't have the resources or the will to enforce it.
"Our job is to inform the people of what should be done, and not make criminals out of people who are not going to follow our ordinance."
Liebling's comment followed a report from Olmsted County Public Health Associate Director Denise Daniels, who said the county had 2,700 new confirmed cases of COVID-19 last week, with 98% of them expected to be linked to the omicron variant.
The number of confirmed COVID-19 cases throughout the pandemic are charted by Olmsted County Public Health, showing the increases seen in recent weeks.
Contributed/Olmsted County Public Health
"In the last two weeks alone, we had an over 400% increase in the cases, which goes to show you just how transmissible this is," she said.
While many people aren't suffering symptoms as severe as those others experienced during previous COVID waves, Daniels said the health system is being overwhelmed.
"There is some narrative out there that omicron is milder," she said. "I think it's important to know that while many folks are experiencing milder symptoms, the sheer number of cases, because of how infectious it is, will continue to drive up our hospital admissions."
The number of hospital admissions by week throughout the pandemic are charted by Olmsted County Public Health.
"We are at an all-time high in the pandemic right now," she added, citing concern about staff shortages, as well as severe outcomes that continue to happen.
"The lagging indicator is always deaths, and we do continue to see some deaths here in the community from COVID," she said as she presented a chart showing more than 10 COVID-related deaths were reported in each of the last two months of 2021 and two or three have been recorded in the first weeks of 2022.
COVID-related deaths in Olmsted County throughout the pandemic are record by whether they occurred in people living in a long-term care facility or other group residence or in a private home. The majority of deaths in recent months have involved people who live in a private residence.
The chart showed another change related to the deaths since the onset of the pandemic in early 2020.
Daniels said deaths were largely occurring among people who lived in long-term care facilities and other group residences during 2020 and the first months of 2021, but increased vaccinations at those sites has led to a shift.
"Most of our deaths are now individuals who are in private residences and not in long-term care facilities," she said.
Olmsted County continues to have the state's second-highest vaccination rate, only following the less-populated Cook County.
The Minnesota Department of Health reports 81.2% of Olmsted County residents have received at least one dose of the vaccine, with nearly 77% completing their series.
Daniels said slightly less than 70% of the vaccinated residents have received a booster dose.
"With waning immunity of those vaccines, this has been critically important to our cases," she said.
Related Topics: GOVERNMENT AND POLITICSROCHESTEROLMSTED COUNTY PUBLIC HEALTHOLMSTED COUNTY BOARD OF COMMISSIONERSTINA LIEBLING
Belmont University – Byron: Tessa Stites; Kenyon: Ally Peterson.
By Post Bulletin staff reports
State suspends license of former Rochester teacher for "grossly inappropriate" conduct
After a 60-month suspension, the former teacher can petition to have his license reinstated if he undertakes a number of steps.
By Jordan Shearer
Mayo Clinic responds to employees upset about lower-than-expected raises
In the wake of complaints by frustrated employees, Mayo Clinic's official explanation is that the raises are calculated solely in comparison to the market. The annual salary adjustment is based on a review of external market factors, the clinic says.
By Jeff Kiger
Dodge Center man pleads guilty to two charges in federal court
Reyel Simmons pleaded guilty to impersonating a federal agent.
By Emily Cutts
Meyers' OT winner lifts Gophers to a dramatic 2-1 win over Michigan

redpajama_set_name: RedPajamaCommonCrawl


First question: Who donated over 22,000 pounds of chia seeds to a food bank?
The Oregon Food Bank in Portland is recalling 22,201 pounds of donated — and apparently contaminated — chia seeds after rodent feces were discovered in the product.
The food bank has initiated a Class II recall of the massive quantities of chia seeds that were distributed in Oregon and Clark County in Washington state between Nov. 1, 2017, and March 9, 2018.
The rodent droppings were discovered after a customer complained about "foreign material" they observed in their chia seeds, according to a press release.
An investigation determined there was "evidence of rodent activity by the donor" of the chia seeds, Live Local Organic of Milwaukie, Oregon.
Oregon Food Bank said the chia seeds were distributed in one-pound plastic poly film bags with a twist-type or resealable closure.
Myrna Jensen, a publicist for the food bank, told BuzzFeed News that "the recall is ongoing." There have not yet been any reported or known illnesses related to the product.
They also suggest contacting your primary physician if you experience any "symptoms of food borne illness."


"I bought my cat a feeding device with a timer to make him lose weight. This is how he sleeps now."
"I started a diet this week. My family is very supportive."
"She said we were on a diet and had to switch from bread to crispbread!"
"First days at the gym!"
And I really wanted to!
"My boss and I have a competition to see who can lose more weight. Today is my birthday, and this was his present."
"I'm trying to lose weight, so I prepare my lunchboxes beforehand."
"My first day on a diet."


BEIJING, April 8, 2016 /PRNewswire/ -- Baidu, Inc. (the "Company") (NASDAQ: BIDU), the leading Chinese language internet search provider, today announced it filed its annual report on Form 20-F for the fiscal year ended December 31, 2015 with the Securities and Exchange Commission on April 8, 2016. The annual report can be accessed on the Company's investor relations website at http://ir.baidu.com.
Baidu, Inc. is the leading Chinese language Internet search provider. As a technology-based media company, Baidu aims to provide the best and most equitable way for people to find what they're looking for. In addition to serving individual Internet search users, Baidu provides an effective platform for businesses to reach potential customers. Baidu's ADSs trade on the NASDAQ Global Select Market under the symbol "BIDU." Currently, ten ADSs represent one Class A ordinary share.


text:
The cure for video fatigue-new research reveals how to combat fatigue and create a vibrant hybrid work culture.
What is hybrid work?
Definition: Hybrid work is a flexible work model that supports a blend of in-office, remote, and on-the-go workers. It offers employees the autonomy to choose to work wherever and however they are most productive.
What is a hybrid work model?
What are the types of hybrid work models?
What factors are driving hybrid work?
What are the benefits of hybrid work?
What is a hybrid work schedule?
How do I build a hybrid work culture?
Are hybrid and remote work good or bad for employee engagement?
Is it safe to return to the office?
Why should I go into the office?
Is there a difference between hybrid work and working from home?
What's the best collaboration solution for hybrid work?
Hybrid work is a people-first approach to managing the workforce that drives increased productivity and job satisfaction while addressing the major challenges of remote work, such as isolation and lack of community. A hybrid work model provides employees with greater flexibility and the option to work from home or anywhere they can be productive. With hybrid work, the workplace is no longer inside the four walls of the corporate office—it's an ecosystem of employees working from home, in coworking spaces, and the office. Team members can migrate between various locations depending on the work they need to get done.
The hybrid work model can take different forms depending on the organization and the type of work being done.
These are the four most common hybrid work models:
1. Flexible hybrid work model
Employees choose their location and working hours based on their priorities for the day. For example, if they need to spend time focusing on a project, they can choose to work from home or in a coffee shop. If they want a sense of community, need to meet with their team, attend a training session or join a town hall, they can choose to go into the office. Cisco is leveraging this model and offering its employees the option to choose where they work on any given day.
Offers freedom and flexibility for individuals to determine where and when they work
Builds a trust-based relationship with employees, which increases loyalty and job satisfaction
Expands talent pool, leading to more diverse thinking
Improves the bottom-line due to cost savings on office space and travel
Difficult for employees to find a suitable day or time for in-person teamwork
Lack of visibility into how many people are going to the office on any given day and if the building has the capacity to support them
2. Fixed hybrid work model
The organization sets the days and times employees are allowed to work remotely or go into the office. For example, it could be that certain teams go into the office on Mondays and Wednesdays, while others go in on Tuesdays and Thursdays. Or an organization could allow everyone to work from home on pre-determined days each week. American Express is an example of an organization that has adopted a fixed hybrid work model.
Increases opportunity for in-person collaboration and team building
Gives employees the option to schedule appointments or run quick errands on certain days of the week
Provides the ability to easily forecast office capacity
Lack of individual choice, which could lead to a loss of productivity if employees aren't in the optimal setting for the work that needs to be done
Inability to reduce office space
3. Office-first hybrid work model
Employees are expected to be on-site but have the flexibility to choose a few days a week to work remotely. Google plans to adopt this type of model where employees work in the office three days a week but have the option to choose two days for working remotely.
Allows flexibility and individual choice
Helps maintain company culture and community
Lack of visibility for employees around who will be in the office and when
Inability to accurately forecast how many employees will be in the office on a given day
4. Remote-first hybrid work model
Employees work remotely most of the time with occasional visits to coworking spaces or the office for team building, collaboration, and training. In this model, the company may not have an office space and instead relies on team members in the same area to get together when they see fit. Twitter adopted this remote-first model and will allow all employees to work from home.
Increases productivity and job satisfaction for employees who want to work remotely most of the time
Provides the ability to reduce costs by reducing or eliminating office space
Potential for employees to feel isolated
Increased challenges maintaining the company culture and community
Hybrid work emerged as a viable work arrangement during the COVID-19 pandemic when businesses transitioned to remote work and used virtual collaboration tools to remain productive. While some organizations had hybrid and remote workers before the pandemic, those working arrangements accelerated overnight as most of the workforce went from in-person meetings to kitchen table virtual collaboration.
Now, after realizing the benefits and challenges of remote work, organizations are adopting hybrid work models to extend greater flexibility to employees while maintaining the in-person interactions that are crucial for the company community and culture.
Numerous surveys and research reveal the factors driving hybrid work:
Remote work has largely proven successful: A majority of executives have seen notable improvements in individual productivity, and diversity and inclusion, according to McKinsey.
Employees are demanding greater flexibility: 57% would consider leaving their company if they had to return to the office full-time, according to Dimensional Research.
Businesses see an opportunity to reduce travel and real estate costs: 74% of CEOs from large organizations expect to reduce their office space, according to Fortune.
Sustainability is top of mind: Daily global CO2 emissions decreased by 19% during the COVID-19 pandemic, nearly half of which resulted from reduced ground transportation, according to research by Nature. Reduced commutes and business travel from hybrid work coupled with a reduction in office space heating and electricity will help promote a more sustainable future. These changes can assist the 60% of Fortune 500 companies with sustainability targets achieve their goals.
The shift to hybrid work brings considerable benefits to both employees, businesses, and the environment. It promises to deliver increased flexibility, productivity, and job satisfaction for employees. For the business, it improves the bottom line and expands the talent pool. And the reduction in travel and office spaces leads to a more sustainable future.
Recent research conducted by Dimensional Research reveals:
99% of knowledge workers see the benefits of working from home, including increased flexibility, no commute, and having more time to spend with friends and family
95% of knowledge workers want to return to the office for activities such as team building, collaboration, and connection to peers
53% of large organizations plan to reduce their office footprint, which reduces costs
A hybrid work schedule is based on flexibility. Your hybrid work schedule will depend on the type of hybrid work model your organization chooses to implement. For some organizations, it will be up to the employee to decide when and where they work on any given day. Others will have set schedules to ensure that teams in the same location can meet in the office or a coworking space for collaboration and team building.
While hybrid work gives you the flexibility to choose your schedule, it's important to communicate your working hours with your team. Team leaders should approach each individual situation with empathy and understanding, and work with their team members to identify a schedule that works for everyone.
A key pillar of hybrid work is the shift from focusing on location and hours worked to the outcomes that are delivered.
Organizations may have concerns about maintaining culture and community when they extend greater flexibility to the workforce. Without watercooler chats or opportunities to interact with colleagues outside of your job function, it can be difficult to facilitate the cross-pollination of ideas. And if the company culture and a sense of shared purpose diminish, it can lead to a loss of productivity and higher turnover.
Therefore, building a culture based on inclusivity, empathy, and trust will be one of the most important aspects of hybrid work.
As work has expanded beyond the walls of the office, keeping the culture intact requires a shift in the way we think about shared purpose. Colleagues need to work together and build connections, whether they are in a room together or virtual, and your collaboration solution needs to facilitate interactions that would occur if people were together in-person.
Organizations can have the best of both worlds when they bring the office and virtual worlds together. Employees can choose where they want to work without missing out on the personal connections and team building that are beneficial to company culture.
They are a good thing! While many expect employee engagement to drop if employees aren't going into the workplace every day, research shows that hybrid and remote work can improve employee engagement. In a recent survey, 79% of knowledge workers indicated that their engagement level has stayed the same or improved since they began working remotely.
For information on when it is safe to return to the office, visit your local government COVID-19 planning site. If you're in the U.S., visit the CDC for the latest guidance.
Bringing people back into the office likely means new protocols and policies to keep employees safe. Social distancing, proof of vaccination, mask requirements, and limiting how many people are in the building may be enforced to ensure safety.
97% of the workforce have concerns about returning, including touching shared office devices, knowing when a room was last cleaned, and knowing if a room is over capacity for safe social distancing. While policies and technology can assist in making the environment safer, the concerns of the workforce will need to be addressed. Communicating these changes will be key to making employees feel comfortable.
For more information on how technology can assist in providing a safe return to the office, download the How-to Collaboration Guide for the Hybrid Workplace.
The office is also a great place to go if you need to remove yourself from a distracting home environment, need to collaborate with your team, or want a sense of community. For many organizations, the office will act as the central hub for rich collaboration experiences, building connections with colleagues, and engaging in education and training.
95% of knowledge workers say they will go into the office for activities such as:
Connections with peers
With a hybrid work model, the purpose of the office must evolve, as will the capabilities that are offered in each space. With 98% believing their future meetings will contain remote participants, video conferencing technology should be available in most spaces. If you plan to reduce your office footprint, you'll need hot-desking and office navigation technology to ensure that everyone can stay productive and get started quickly in any space.
Yes, hybrid work and remote work are different. Remote workers work from home all the time and may not have the option to go into the office. While hybrid workers will spend a portion of their time working from home, they also have the flexibility to choose where and when they work. According to research, 49% of remote workers feel isolated, 37% encounter more distractions, and 35% find it hard to connect with their colleagues. Hybrid work provides options for employees to decide which days they want to go into the office. If a person is feeling a sense of isolation, wants to remove themselves from a distracting environment, or connect with colleagues, they have the option to go into the office.
Choosing the right collaboration solution is one of the most important decisions you'll need to make as you adopt a hybrid work model. When the pandemic hit, many organizations had to make quick decisions about what technology they were going to adopt to support a remote workforce. But quick decisions are not often the best decisions.
Hybrid work redefines what it means to work and collaborate in a more distributed yet more connected world. This shift challenges us to rethink the experiences employees need to remain productive and easily collaborate wherever they are. T-Mobile is a great example of a company that quickly realized the challenges of hybrid work and invested in a comprehensive hybrid work solution to help bridge the gap between remote and in-office workers.
When evaluating the best solution for hybrid work, you'll want to look at the experience and needs of every employee in the organization. Start by asking key questions, including:
Are my employees equipped to work from home?
Can my employees expect the same collaboration experience whether they are in the office or at home?
Can the solution provide IT with the ability to easily scale, monitor, and manage the experience when employees are working from home or in the office?
Do employees feel included in meetings? Are there easy ways for them to engage and be seen and heard?
Is the collaboration solution secure?
At Webex, we're continuously innovating to make working from home and in the office an inclusive, secure, and connected experience for everyone. Learn more about how Webex is solving the challenges of hybrid work.
Continue your hybrid work journey
Take the Hybrid Work Readiness Assessment
In 10 minutes or less you can evaluate and benchmark your organization's hybrid work readiness.
Understand the 6 strategies for hybrid work success
365 days. 3 global surveys. 3,935 workers. Our quest to understand the changing nature of work and collaboration all boiled down to 6 transformative strategies. Download the report.
Explore Cisco's Hybrid Work Index
Cisco analyzed millions of records of customer telemetry data – aggregated and anonymized – to uncover insights and trends for the hybrid work era.
The Future of Work is Hybrid
Download this collection of trends and insights that emerged from our independent research into the nature of hybrid work.


text:
Posts Tagged 'Harold Koh'
Replacing Souter
There's a few different schools of thought on how Obama should go about replacing Justice David Souter. Dahlia Lithwick – a few months ago – called on Obama to make his next appointment "a hero, a bomb-throwing, passionate, visionary, liberal Scalia." Others are just calling for Obama to place someone liberal enough to counter-balance the extreme conservatives appointed by Bush. Conservatives and right-wingers are calling on Obama to appoint someone "moderate" – though given the political circumstances, it is almost guaranteed that they will not accept any appointment, no matter how "moderate." All of this is based on a rather direct analysis of the Supreme Court – presuming that decisions are and will be made based on political viewpoints.
I'm not trying to say that we should accept Justice Roberts's oft-cited analysis of the judge as umpire – just calling the law as he sees it. I thought Obama made an excellent point back in July 2007 when he critiqued this view:
When Roberts came up and everybody was saying, "You know, he's very smart and he's seems a very decent man and he loves his wife. You know, he's good to his dog. He's so well qualified."
I said, well look, that's absolutely true and … in the overwhelming number of Supreme Court decisions, that's enough. Good intellect, you read the statute, you look at the case law and most of the time, the law's pretty clear. Ninety-five percent of the time. Justice Ginsberg, Justice Thomas, Justice Scalia they're all gonna agree on the outcome.
buy furosemide 20 mg But it's those five percent of the cases that really count. And in those five percent of the cases, what you've got to look at is—what is in the justice's heart. What's their broader vision of what America should be. Justice Roberts said he saw himself just as an umpire but the issues that come before the Court are not sport, they're life and death. And we need somebody who's got the heart—the empathy—to recognize what it's like to be a young teenage mom. The empathy to understand what it's like to be poor or African-American or gay or disabled or old—and that's the criteria by which I'll be selecting my judges. Alright?
Ed Whelan over at the Corner is trying to make a big deal out of what he's calling Obama's lie – which is that judicial philosophy is unimportant. He cites the above quote as proof Obama thinks judicial philosophy is unimportant – but he doesn't seem to have read it closely, as you can clearly see Obama say:
[I]t's those five percent of the cases that really count.
The person Whelan really should be attacking – if he believes judicial philosophy is unimportant – is Justice Roberts who sought to minimize the role of politics in his decisions (at least in his pre- and post-appointment rhetoric.)
But what I'm interested most in is a justice who can move the other members of the Court – either through personality or their compelling understanding of the law. One historical type that has moved the Court would be a politician – such as Sandra Day O'Connor or Earl Warren – whose personality drew other justices to accept some of their decisions, and gradually shaped the Court over time. This is why I think it's a bad idea to appoint a liberal version of Justice Scalia – whose personality actually hurt his politics. Jennifer Granholm is a good possibility on this front. As would Hillary Clinton or Al Gore if they were only younger.
In the alternative, Obama could appoint an ideologically interesting thinker – who is liberal, but nevertheless, thinks outside of the box. The two people that come to mind on this score are Cass Sunstein and Lawrence Lessig. Lessig is probably too young yet – and Sunstein has not only encountered surprising resistance to his appointment to an obscure position, but he probably would like an opportunity to take a crack at enhancing that position and testing his theories on libertarian paternalism.
Finally, I like Harold Koh for the post – even though it is unlikely he fits into any of the above two categories. He's national security thinker with a great resume. I don't know his record on most issues – but I've heard him speak on national security law – my main interest – and he has strong, nuanced positions, viewing our national security apparatus as a whole system rather than as a series of isolated issues. He would be a strong voice in reigning in an executive branch that has barely pulled back in terms of it's assertions of power in the national security arena.
Tags: Antonin Scalia, Cass Sunstein, Dahlia Lithwick, David Souter, Earl Warren, Ed Whelan Justice John Roberts, Harold Koh, Jennifer Granholm, Lawrence Lessig, Sanda Day O'Connor, Supreme Court
Posted in Barack Obama, Law, Political Philosophy, Politics, The Opinionsphere | No Comments »
The Last Thing We Need Is A Liberal Scalia
Dahlia Lithwick, who I rarely fail to mention, is one of my favorite writers, had a piece a few days ago on what she wants. In a Supreme Court justice that is. And I lightly paraphrase:
Wonky liberal lawyer seeking a hero, a bomb-throwing, passionate, visionary, liberal Scalia for a seat on the Supreme Court!
One of the main facts revealed in all those recent scholarship of the Rehnquist (O'Connor) court, though, was that Scalia's brash personality and insulting style actually pushed the moderates to the left – or drove them to be less susceptible to being wooed to Scalia's side in an argument. Though the Court has indisputably moved far to the right since Scalia entered it, seven of the past nine Supreme Court justices have been appointed by Republican presidents. The two appointed by Clinton were moderates chosen to be confirmed by a Republican Congress. Yet, the Court has only moved slowly towards conservative positions. There are many explanations of this, but for anyone who considers the social dynamics of the Court to be significant – and from her article Dahlia seems to be one who does – then Scalia's antagonistic approach to O'Connor's sloppy reasoning and Kennedy's pomposity certainly must be one factor. A brash, bomb-throwing liberal then is exactly what the Court doesn't need.
What I think it does need is a libertarian-minded liberal who can forge an alliance with Scalia on certain issues – and perhaps Thomas as well. Both Alito and Roberts seem to be enamored of executive power – and perhaps that was why it was they who were chosen. I consider them lost causes. But Scalia and Thomas are conservatives of an older school – one which a contemporary liberal – such as Lawrence Lessig or even Cass Sunstein – has much in common with.
I think Dahlia would be happy with that though – a Lessig, a Sunstein, and a Lawrence Tribe. Perhaps a Harold Koh and an Elena Kagan. Instead of a bomb-thrower, I think Dahlia just wants a liberal with a vision instead of an incrementalist. On that, I agree.
Tags: Antonin Scalia, Cass Sunstein, Dahlia Lithwick, Elena Kagan, Harold Koh, Lawrence Lessig, Lawrence Tribe, Slate, Supreme Court
Posted in Barack Obama, Law, Liberalism, Politics | 1 Comment »
What's Next: The Court
Before the election, some Republicans were trying to gin up some controversy by imputing obscure and extreme judicial views on Barack Obama – focusing especially on remarks he made in July 2007, described here by The Hill:
"[Chief] Justice Roberts said he saw himself just as an umpire," Obama said. "But the issues that come before the court are not sports; they're life and death. We need somebody who's got the empathy to recognize what it's like to be a young teenage mom."
Obama said that 95 percent of cases can be judged on intellect, but that the other 5 percent are the most important ones.
"In those 5 percent of cases, you've got to look at what is in the justice's heart, what's their broader vision of what America should be," Obama said, adding that justices should understand what it's like to be gay, poor or black as well.
Steven Calebrisi, founder of the Federalist Society, wrote a very influential piece appearing in the Wall Street Journal in which he combined the most extreme possible interpretations of the statement about empathy (first taken out of context) with a somewhat bizarre (but politically very useful for the McCain camp) interpretation of remarks Obama made in a 2001 radio interview about the Warren Court. This led Calebrisi to the grandiose conclusion that:<
Nothing less than the very idea of liberty and the rule of law are at stake in this election. We should not let Mr. Obama replace justice with empathy in our nation's courtrooms.
Putting aside the fact that Calebrisi did not find it necessary to raise his voice against those who used his own legal theory – that of the unitary executive – to actually and explicitly place the president above the law, Calebresi's concern here is misplaced, as I think you can see just by reading the passage above from The Hill.
But if Calebresi's half-assed op-ed doesn't help us understand who Obama would appoint to the Court, then what does?
After all, Supreme Court appointments can be a president's greatest legacy – affecting policy for many years after a president has gone.
how to buy gabapentin online Potential Supreme Court Justices
Obama, as a former constitutional law professor, has obviously put a great deal of thought into who he might appoint to the Supreme Court. Many names have been floated – politicians like Jennifer Granholm, Janet Napolitano, Hillary Clinton, and Ken Salazar; academics such as Harold Koh, Elena Kagan, and Cass Sunstein as wel as a number of current judges. With Ruth Bader Ginsburg and John Paul Stevens likely to retire during Obama's term, and David Souter wishing – according to Jeffrey Toobin, author of The Nine – to withdraw back to the19th century lifestyle he enjoys in New Hampshire away from the Court, Obama could get three – and if Obama is reelected in 2012 – even four nominations to the Court. Justice Scalia will undoubtably do everything possible to avoid retiring during Obama's presidency, but he is getting older as well – and would be 80 by 2016. Justice Kennedy would be 80 as well – but he does seem to so enjoy being the swing vote that it is hard to see him ever leaving the Court.
Superficial factors in choosing the justices
Any justices Obama appoints will undoubtably be younger than is traditional – as Bush recently appointed two conservatives in their 50s in Roberts and Alito.
It is also likely that, as the Supreme Court has traditionally been factionalized by race, religion, and gender – from the mid-1800s when there was a "Jewish seat" on the Court and a "Catholic seat" to focus on keeping women and African Americans since the 1980s – Obama will want to appoint at least one woman and on Hispanic to the Court.
The Dynamics of the Court
Obama has spoken of how Justice Warren – as a former politician – was able to win majorities by winning over the other justices. Jeffrey Toobin, writing about the Court over the past decade, has described Sandra Day O'Conner having a similar role during her tenure. In fact, since the Court's founding, former politicians have had a way of dominating the stately and apolitical Court – beginning with John Marshall. Which is why the first appointment Obama makes should be a former politician – probably a woman. Especially if John Paul Stevens, the unofficial leader of the liberal wing of the Court, retires, Obama will want a strong personality to take his place. As Janet Napolitano is the favorite to become Attorney General, that leaves Jennifer Granholm, Governor of Michigan and a former state attorney general as the most logical choice.
Beyond this first choice of a female politician, Obama's options are more open.
For his second nomination I would reccomend an academic – Elena Kagan, dean of Harvard Law, or Harold Koh, dean of Yale Law, would be the logical choices here – as both are young and prominent liberals in academia. Koh's name has apparently been generating real buzz as a potential Obama pick.
Certain to be on any short list is Cass Sunstein is an important legal scholar and a close friend of Obama's. He recently wrote a book with the conservative economist Richard Thaler about libertarian paternalism.
There is one potential candidate I have not heard mentioned though – and especially if Scalia were to retire from the bench, this former Scalia law clerk, former Reaganite, and former libertarian would be the perfect choice – Lawrence Lessig, whose innovative work founding Creative Commons and now the Change Congress movement, and whose influential work on internet law, copyright and corruption have made him a legal star.
Libertarianism v. Liberalism
With these four appointments, Obama could profoundly alter the Supreme Court's ideological make-up – by replacing the traditional statist liberals and Rockefeller Republicans on the Court making up it's current left wing with a charismatic pragmatist, and other liberal, and two libertarian-influenced liberals.
Tags: Cass Sunstein, Elena Kagan, Harold Koh, Hillary Clinton, Janet Napolitano, Jennifer Granholm, Ken Salazar, Lawrence Lessig, Steven Calebresi, Supreme Court
Posted in Law | No Comments »
Subscribe to 2parse's RSS Feed.
Or subscribe to 2parse by Email
The Daily Beast's Cheat Sheet
David Rothkopf
Stephen Walt
jwcampbe resources
Larger Version (Link now works.)
Al Qaeda Andrew Sullivan Bill Clinton Charles Krauthammer Council on Foreign Relations David Brooks Dick Cheney Ezra Klein Facebook Financial Times Foreign Policy George W. Bush George Will Glenn Greenwald Hillary Clinton Iran Jonathan Chait Jon Stewart Marc Ambinder Marijuana Matt Yglesias Meet the Press National Review Net Neutrality Newsweek New Yorker New York Times Paul Krugman Ronald Reagan Rule of Law Rush Limbaugh Salon Sarah Palin September 11 Slate Stimulus The Atlantic The Corner The Drudge Report The New Republic The New York Times torture Wall Street Wall Street Journal Washington Post
a blog of human failure
Baldwin Park Democrat
Blue Girl, Red State
Freedom Democrats
George F. Will
Kiko's House
Lawrence Lessig
The Grand Panjandrum
The Insatiable Itch
Violent Acres
Slate Magazine
The Washington Post Opinion section
BBC's From Our Correspondent
WNYC's Radio Lab
WNYC's The Brian Lehrer Show
1AdRemove
Energy Independence
Excerpts from my Journals
Fiscal Crisis
Post 9/11 Generation
Scandal-mongering
The Bush Legacy
The Clintons
The Opinionsphere
The War on Terrorism
The Web and Technology
2parse is proudly powered by WordPress


Westpac Banking Corporation today announced the appointment of Lester Wynne-Jones as its State General Manager in South Australia.
Based in Adelaide, Lester will be responsible for Westpac's retail banking business and branch presence in South Australia, Northern Territory and Tasmania comprising of 62 branches, of which five are Bank Now, and over 500 staff.
With a banking career spanning 30 years with HSBC in United Kingdom, Lester brings extensive experience to the role. He was responsible for HSBC's Regional Retail Banking across flagship geographies including London, South and South East managing the delivery and ongoing development of a full range of services to HSBC's retail customers. He has also held various senior management roles in offices in Canada, United Arab Emirates, and Kazakhstan.
Announcing his appointment, Westpac's General Manager, Retail Banking, Gai McGrath described Lester as a talented and experienced candidate who would play a critical part in building on the success of the bank's local strategy in South Australia.
"Lester's extensive international experience and leadership roles made him the ideal candidate to take on this position. His appointment underlines Westpac's commitment to making a difference in South Australia, through great service to our customers, continued investment in our banker capability and our branch and business banking centres as well as ongoing support for and engagement with local communities."
Commenting on his appointment, Lester said he was looking forward to the challenges and rewards that come with joining Westpac in South Australia.
"There are some exciting prospects ahead for South Australia and I look forward to bringing my experience and passion to the role to provide enhanced service and support to local retail and business customers."


Airtel customer care number in Lucknow, Airtel toll free helpline number, grievance officer, nodal officer contact details, Airtel store address in Lucknow and other details are provided below. We provide customer support numbers for both airtel mobile, airtel fixedline, airtel fiber and broadband services.
Shop no UGF 8&9,PLOT NUMBER 1,GURUDWARA ROAD,BANSMANDI CHAURAHA.
I have registered my no.for 4 g 1 week back yet my sim is not activated…….
I have ported my aircel number to airtel number and it has been 10 days since i have ported but my number has yet not ported.
Sir,Maim, Please mere mo.no.9794092999 me Date 10.08.2018 ko blance 3966 paise tha na maine kahi koi bat ki na he mere no. per koi service activate hai to fir mere blance 445paise kaise ho gaya please mera 3966 paise blance wapas karne ka kast kare thanku.


What makes an ETF investor? Are you one? Should you be?
As the U.S. exchange-traded product market matures, data sets used to characterize the "ETF investor" have gotten richer but the answer is no more clear.
Exchange-traded products--funds, notes, commodity pools and more--allow access to investment strategies that might be more expensive for an individual investor, adviser or even institution to implement alone. Some are indexed; others are futures-based; a few are actively-managed. The trade-off you make for access is market pricing.
Understanding yourself as an "ETF investor," then, depends upon the lens.
In a recent research paper entitled "ETFs: For the bettor or better?," Vanguard declared that investors holding ETFs are not "tempted to trade," despite allegations as such.
The paper examined four large index funds and ETFs that could be core holdings for any passively-inclined investor at Vanguard. Those funds: Vanguard Total Stock Market (VTI), Vanguard Total Bond (BND), Vanguard Emerging Markets (VWO) and Vanguard REIT (VNQ).
Vanguard's unique fund structure, whereby its ETFs are a share class of the mutual fund, and its position as a record-keeper of brokerage trades gives the company the basis for its research.
Vanguard concludes that ETFs may be chosen by those who might prefer to trade as opposed to ETF holdings directly causing increased trading. The researchers conclude a typical ETF investment at Vanguard to be roughly 15% less likely to be buy-and-hold than a traditional mutual fund investment.
Yet, because most ETF trading is done in the secondary market, not the fund level, Vanguard concludes that having such "traders" in the ETF is advantageous to the fund because the churners have been offloaded to trade with the market. In fact, Vanguard offers traditional fund holders a one-way conversion to ETF shares (with some exceptions, including Total Bond) and offers free brokerage trades on ETFs, allowing the company to segment its own customers.
It's almost as that which was to be proven...was already preordained.
For a wider look, Charles Schwab distributes a quarterly snapshot of ETF trends on its platform. At the end of June, ETF assets custodied at Schwab accounted for $135 billion, or roughly 10% of the entire U.S. ETF market.
Holdings broke down to 10% for retail traders, making at least 36 trades per year; 40% retail investors and 50% RIA clients.
Year-to-date trading stacks up differently, but also not unexpected. Retail traders accounted for 29% of trades; retail investors for 35%; and RIA clients for 36%.
Unlike Vanguard, which is looking at apples-to-apples activity among Vanguard investors, the Schwab picture is broader, encompassing all possible products custodied at Schwab and the definition of a retail investor (individual account, sub 36 traders per year) is their own.
By Schwab's estimation, retail traders churn almost three times their asset-weighted representation in ETF holdings, retail investors just 88% and RIA clients just 72%.
Other companies trying to analyze the ETF investor recently included institutional agency brokerage ITG, which highlighted the under-representation of traditional asset managers in ETF trading, as well as Greenwich Associates take on the growing use of ETFs by institutional clients. Less understanding lies is in the segmentation of leveraged-fund investors (hat tip to the SEC) and those buying and trading notes or commodity pools.
How would/do you behave as an "ETF investor"? My guess is not dissimilar to how you behave as a regular investor.
The need to educate investors about the uses (and abuses) of ETFs is colliding with larger trends in asset management and investing: active vs. passive, RIA vs. broker, stock vs. fund. At the end of the day, both investors and asset managers should want to be in the right products for the right reasons.
The sooner we get beyond the "ETF investor" the better.


text:
The Anderton family was a notable family, which was divided into several branches and lived in various places throughout the historic county of Lancashire, England. After the Reformation they provided a number of prominent Roman Catholics.

Prominent members included:

James Anderton (1557–1618).
Laurence Anderton, alias Scroop (1577–1643).
Venerable Robert Anderton (1560–1586).
Roger Anderton (died 1640).
Thomas Anderton (1611–1671).

See also

Anderton baronets

References

History of Lancashire
History of Catholicism in England

redpajama_set_name: RedPajamaWikipedia


1996 Scientific Lyceum (60/60) Liceo Carlo Cattaneo, Follonica (GR), Italy.
2011 to date Collaboration with Dylan Lab, CNR-ILC, Pisa.
Participation to a project about research of replication origins in DNA, with Prof. Arturo Falaschi (IFC-CNR Pisa), just before his death.
modelling, animation and visualization of macromolecules and proteins by professional mathematical programs, bioinformatic software, visualization and 3D animation programs.
2005-2008 PhD student in Bioengineering about the evaluation of compliance and stiffness of biological and artificial muscles (elastomeric actuators) during movements. Didactic activity in the Analysis I course at Biomedical Engineering, University of Pisa.
2004-2005 Collaboration with Interdepartmental Research Center "E.Piaggio" about the modelization of neural and neuro-glial messages in human brain. Participation in European Projects: MyHeart (IST 507816).
2004 Collaboration with CNR of Pisa about the modelization of electrocardiographical signals.
"Evaluating Hebbian Self-Organizing Memories for Lexical Representation and Access", C. Marzi, M. Ferro, C. Caudai, V. Pirrelli, in proceedings of Eighth international conference on Language Resources and Evaluation (LREC 2012), N. Clazolari, K. Choukri, T. Declerck, U. DoAYan, B. Maegaard, J. Mariani, J. Odijk, and S. Piperidis (eds.), ISBN 978-2-9517408-7-7, published by European Language Resources Association (ELRA), Istanbul (Turkey), pag. 886-893, 2011.
"Stiffness control of biomimetic systems through recruitment of bundle elastomeric actuators" Lorussi F.,Caudai C., Galatolo S., De Rossi D., in Dielectric elastomers as electromechanical transducers, Carpi F.,De Rossi D., ch. 30, pp 1194-1199, 2008.
"FACE e la sua mente" (trad: FACE and its mind) Casalini S., Pioggia G., Ferro M., Caudai C., De Rossi D., in La Bioingegneria del Sistema Cervello-Mente (trad: The Bioengineering of the Brain-Mind System), ch. 5., Biondi Ed., Collana di Bioingegneria, Patron, 2006.
"Sensory fusion and emerging behaviours in an anthropomorphic robot as a man-machine interface" Pioggia G., Ferro M., Caudai C., Casalini S., Ahluwalia A. De Rossi D., in Book of Abstracts of the International SenseMaker Workshop on Life Like Perception Systems, Derry (North Ireland),2005.
"Modelli di Reti Neurali e Glia. Essere Presenti, Esseri Presenti" Caudai C., Casalini S., De Rossi D., in Atti Interni dell'Università di Ingegneria di Pisa, Pisa, 2004.
"BioBlender: Fast and Efficient All Atom Morphing of Proteins Using Blender Game Engine" M. F. Zini, Y. Porozov, R. Andrei, T. Loni, C. Caudai, M. Zoppè. Sept 2010.
"BioBlender.Molecular animation and scientific representation",M. Zoppè, Y. Porozov, R. Andrei, S. Cianchetta, M. F. Zini, T. Loni, C. Caudai, M. Callieri. in Blender Art Magazine, Issue 21, pp 64-70, April 2009.
"Blender for biology. The making of Protein Expressions – Study N 2 ",M. Zoppè, R. Andrei, S. Cianchetta, M. F. Zini, T. Loni, C. Caudai, M. Callieri. In Proceedings of the Blender Conference, 2009.
"Stiffness and Compliance Control in Dynamical Systems Driven by Muscle-Like Actuators", F. Lorussi, S. Galatolo, C. Caudai, D. De Rossi , ASME (American Society of Mechanical Engineers ), April 2009.
"Using Blender for molecular animation and scientific representation",M. Zoppè, Y. Porozov, R. Andrei, S. Cianchetta, M. F. Zini, T. Loni, C. Caudai, M. Callieri. In Proceedings of the Blender Conference, 2008.
"Compliance control and Feldman's muscle model", F. Lorussi, S.Galatolo, C. Caudai , A. Tognetti, D. De Rossi , Biomedical Robotics and Biomechatronics, 2006.
1st NetWords Workshop "Understanding the Architecture of the Mental Lexicon: Integration of Existing Approaches", CNR Research Campus, Pisa,Nov 2011.
EMBL Symposium: "Light Microscopy meets Structural Biology", Heidelberg, June 2009.
GNB 2008 – Primo Congresso Nazionale di Bioingegneria, Stiffness and Compliance Control for Kinematic Chains in Motion, C. Caudai ,F. Lorussi, S. Galatolo, D. De Rossi , Pisa, July 2008.
IEEE Biorob 2006 – International Conference on Biomedical Robotics and Biomechatronics, "Compliance control and Feldman's muscle model", F. Lorussi, S. Galatolo, C. Caudai , A. Tognetti, D. De Rossi , Pisa, Feb 2006.
International Sense Maker Workshop on Life Like Perception Systems, "Sensory fusion and emerging behaviours in an anthropomorphic robot as a man-machine interface" Pioggia G., Ferro M., Caudai C., Casalini S., Ahluwalia A. De Rossi D., Ireland, 2005.
Neurological Rehabilitation Workshop Pisa, Nov 2005.
2nd European School of Neuroengineering "Massimo Grattarola", Genova, June 2004.
XXIII Annual School of Bioengineering – Advanced Methods in Biomedical Signals Elaboration, Brixen, 20 – 23 Sept 2004.
Good basic knowledge of French.
Very good knowledge of programs for Numerical Analysis, Statistical Analysis and Variational Calculus: MAPLE, MATLAB, FreeFem++, R.
Good knowledge of programs of Molecular Biology Visualization (Pymol, Swiss PDB Viewer, Jmol, BioBlender).
Good basic knowledge of graphics application software, in particular Blender 3D.
Involved in projects of International Cooperation with Engineers Without Borders (www.isf-pisa.org).
I've a daughter, Zoe (23/04/2012).


text:
Charity calls for urgent action for neurology services
by Gareth Jones
Urgent action needed to support struggling Scots families
13th January 2022 by Robert Armour
MS Society Scotland wants to see better support for those with long term conditions
A Scottish health charity is calling for the government to take urgent action to improve neurology and MS services.
Multiple sclerosis (MS) Society Scotland handed in an open letter at Holyrood last week (Thursday 28 October) to the public health minister Maree Todd MSP.
With more than 1,000 signatures, the letter urges the Scottish Government to address the crisis in neurology care and take steps to ensure everyone with MS can access the support they need.
With one in five people in Scotland living with a neurological condition, findings from the MS Society's #NeurologyNow report – released in October – reveal that neurology services are severely stretched, underfunded, and overlooked. The report also exposes the devastating impact of the Covid-19 pandemic on already-struggling neurology services.
The findings reveal:
• Only one in 10 neurology professionals say their service has complete access to the range of professionals' people with MS need.
• Almost two thirds (63%) of neurology professionals find it extremely or very challenging to provide a good service to all their patients.
• During the pandemic people with MS experienced their symptoms worsening, with over half (53%) saying this was caused by not getting specialist support.
The research follows a Public Health Scotland report from June 2021, which showed over 15,500 Scots – the equivalent number of people living with MS in Scotland – are waiting for an outpatient neurology appointment, up 25% from December 2020.
As waiting lists have gone up, the number of people being diagnosed with MS has gone down. There were just 450 people diagnosed in 2020, compared to 540 in 2019.
Morna Simpkins, director of MS Society Scotland, said: "The findings from our report are deeply troubling. Neurology and MS services have been stretched, underfunded and overlooked for years and this can't continue.
"MS can be relentless, painful and disabling, so having access to the right professional support at the right time is essential. Healthcare professionals, like MS nurses, want to support people with MS – but there simply isn't enough of them and the backlog from the pandemic is huge. We need to see urgent action from both the Scottish and UK Governments to address this crisis – they're close to breaking point."
Mary, 69, from the Borders, was diagnosed with relapsing MS in 1983.
The retired NHS manager she spoke of her experience of accessing healthcare during the pandemic.
She said: "In the Borders, we've been without an MS Nurse for more than six months because our former nurse retired and the health board has only just recruited a replacement.
"Getting support from an MS Nurse is absolutely vital. Before we lost our MS Nurse, I would get two reviews a year to see if I needed any support to help manage my MS symptoms.
"Losing our MS Nurse has meant our Neurologist has been doing two jobs for the last six months, so this has definitely had an impact on the support.
"During the pandemic, my mobility issues have gotten worse. My balance isn't as good as it used to be and I can't walk as far.
"More than three months ago, I spoke to my Neurologist and they said they wanted to see me in person as soon as possible to assess my mobility. It's now October and I still don't know when I will be seen.
"We only have one hospital locally and that covers a large area geographically. Since COVID they've turned the day service into a Covid assessment service. Now, getting a face to face appointment for neurology is really difficult.
"My mobility issues can't really be properly assessed over the phone so until I get a face-to-face appointment, I can't get the support I need."
A Scottish Government spokesperson said: "We welcome the MS Society's report on the issues faced by people with MS and wider neurological conditions throughout the Covid-19 pandemic and public health minister Maree Todd recently met the MS Society to discuss the findings and the ongoing development of MS services in Scotland.
"We're committed to ensuring that people living in Scotland with MS are able to access the best possible care and support, and benefit from safe, effective and person-centred healthcare.
"That's why we're investing £4.5 million over five years to implement our National Neurological Framework and over the last year we have we have awarded £1.4 million to fund innovative projects and invested more than £300,000 to projects which improve the health and wellbeing of people with MS in Scotland."
Charities aim to boost vaccine drive
Charity calls for "right to rehab"
Charity wants to see world leading social security system created
Charity manifesto calls for better emotional support


text:
Home > Business & Economy > Europe backs copyright reforms targeting Google and Facebook
TY Lim/Shutterstock.com
Europe backs copyright reforms targeting Google and Facebook
Europe has endorsed an overhaul of its two-decade old copyright rules, which will force Google and Facebook to pay publishers for the use of news summaries and make them filter out protected content.
The European Parliament backed the reforms by 348 votes to 274 after a debate that has pitted Europe's creative industry against tech companies, internet activists and consumer groups concerned that the new rules may be too costly and block too much content.
Catherine Stihler, chief executive of the Open Knowledge Foundation, said: "This vote is a massive blow for every internet user in Europe. MEPs have rejected pleas from millions of EU citizens to save the internet, and chose instead to restrict freedom of speech and expression online.
"We now risk the creation of a more closed society at the very time we should be using digital advances to build a more open world where knowledge creates power for the many, not the few. But while this result is deeply disappointing, the forthcoming European elections provide an opportunity for candidates to stand on a platform to seek a fresh mandate to reject this censorship."
The European Commission began reviewing the rules two years ago in a bid to protect an industry that is worth 915 billion euros ($1.03 trillion) a year, accounting for 11.65 million jobs and 6.8 percent of the EU economy.
The new rules mean that Google and other online platforms will have to sign licensing agreements with musicians, performers, authors, news publishers and journalists to use their work online. Google's YouTube, Facebook's Instagram and other sharing platforms will also have to install filters to prevent users from uploading copyrighted materials.
Both provisions triggered fierce lobbying from both sides.
The Commission's digital chief for Europe Andrus Ansip welcomed the outcome, saying the reforms would improve the position of writers, journalists, singers, musicians and actors vis-a-vis the big platforms using their content.
"Today's vote ensures the right balance between the interests of all players – users, creators, authors, press – while putting in place proportionate obligations on online platforms," he said in a statement.
Demonstrators take part in a protest in front of the European Parliament as Members of the European Parliament debate on modificationS to EU copyright reforms in Strasbourg, France, March 26, 2019. REUTERS/Vincent Kessler
But Google said the reforms would lead to legal uncertainty and hurt Europe's creative and digital economies. The European Consumer Organisation (BEUC) echoed the criticism.
"Consumers will have to bear the consequences of this decision. Their concerns had been voiced loud and clearly but MEPs chose to ignore them," BEUC director general Monique Goyens said.
Firefox browser-maker Mozilla was scathing about the vote."The EU institutions have squandered the progress made by innovators and creators to imagine new content and share it with people across the world," its EU policy head Raegan MacDonald said. "They have handed the power back to large U.S. owned record labels, film studios and big tech.
Vast swathes of online services, not just those concerning music or news, could face unintended consequences, said Raffaella De Santis at law firm Harbottle & Lewis. "Care will need to be taken to ensure that smaller services are not disproportionately disadvantaged by measures which are in reality designed to curtail the formerly unchecked power of the tech giants," she said.
Glasgow's M Squared Lasers named among Tech Nation's 2019 'Future Fifty' firms
Turing Fest announces 2019 speakers
The tech manifesto: incoming government urged to invest in digital
Teams work over the weekend on Edinburgh Tourism Innovation Challenge
Will Peakin, October 9, 2017 2 min read
Smart Shenzhen seminar showcases business and collaboration opportunities
Will Peakin, July 20, 2018 6 min read
Covid tech transformation doubles revenues at Scottish data centre
Poppy Watson, July 21, 2021 2 min read
Apple gives ageing Macs and iPad Pro updates at New York event
Will Peakin, October 30, 2018 3 min read
Offsite manufacturing is a 'game changer'
Stephen Good, January 18, 2018 2 min read


She was one of the first female Marine infantry NCOs: Remedios Cruz, 26, was among the first females to pass the rigorous Marine Infantry course, according to the Marine Corps Times. In 2017, she joined the 1st Battalion, 8th Marines at Camp Lejeune, North Carolina. Now, she is being kicked out of the Marine Corps because of a relationship she had with a subordinate Marine in her unit…and ultimately married him. The USMC is currently deciding whether or not she will receive a "less than honorable discharge" because of it.
The initial charges were adultery, fraternization, and accessory to larceny. The investigating officer found no probable cause for the adultery or larceny charges. She plead to the fraternization charge.
This are several problems with attempting to integrate women into areas not traditionally available to females in the Military. Cruz was part of history, she proved that she could pass the test, at least the test she was given. But the presence of females, particularly good looking females, in the middle of men will always be a problem.
"The Social experiment gone wrong. Yes, fraternization does occur in our Military, yes higher ranks marry lower ranks all the time in various admin and support units but what some don't understand is that fraternization cannot be prohibited in the Marine Corps Infantry. It's a different breed of Marines and will always be. Fraternization will get good men killed.
Was she made an example? I doubt it, they put too much into this social experiment to go wrong. The Female Marine was busted down by pleading guilty for a lesser punishment. We will never know the full extend of this case where even larceny was a charge. I really doubt the Marine Corps wanted this type of news to come out and I am positive the brass did everything to guide the female Marine from making any mistakes that would dishonor the Corps and her unit.
Everyone loses with this social experiment that likely is costing us billions of dollars to integrate women into combat roles. The media attention that this has created around the individual female Marines is enough to cause friction. The Military claims they treat women and men equally but when was the last time you read an article of a male Marine who couldn't pass Recon qual or a male recruit who who can't pass Marine Corps Infantry course?
When Cruz joined the battalion in January of 2017, she was promoted to Sergeant.
She said she began a relationship with a lower-ranking Marine in her unit and married him shortly before the battalion deployed to Japan in August 2017. Not until she was overseas did senior commanders become aware of the relationship, and opened an investigation.
The investigating officer eventually found that "appropriate administrative or disciplinary" action was warranted, leaving the chain of command to decide whether to issue any punishment.
Mr. Berry, the Marine Corps lawyer, said that fraternization within the ranks is often heard about but rarely punished by court-martial.
Her battalion commander at the time, Lt. Col. Reginald McClam sought to punish Corporal Cruz for creating an "environment which compromised her professional reputation and ultimately the good order and discipline of the unit," he wrote in his recommendation after the initial investigation.
Both the commanding officer of the Fourth Marine Regiment and the commanding general of the Third Marine division — two senior officers above Colonel McClam while his battalion was deployed to Okinawa — recommended no disciplinary action.


text:
THE ISLAMIC SCIENTIST WHO MADE THE WORLD READ
Rana Dajani is a Jordanian-born PhD in molecular biology, an expert in genetics and a globally recognized social entrepreneur. Considered one of the most influential researchers in the Islamic world, Dajani was ranked 12th among the 100 most influential Arab women in 2015 and that same year she was inducted into the Hall of Fame for the most recognized Scientific Women on the planet for her contributions to the science.
The list of recognitions, scholarships and awards is endless, but Rana Dajani shares her time between science and laboratories, classes with university students and the animation of reading with thousands of children around the world thanks to 'We love Reading', a nonprofit organization that motivates the children of the world to read, uniting families through letters, sheets of paper and illustrations and creating social leaders capable of solving problems in their communities thanks to books.
Encouraging reading in Jordan. Photo: 'We Love Reading'
As a scientist, Dr. Dajani knows more about the importance of observing and has based her life on finding solutions through research. She is a world leader in searching for clues and it was precisely this that led her to realize that many children in the Middle East region did not read for pleasure and tended to associate reading with schoolwork. When Rana came back to her native Jordan, after five years of studying, she sadly saw the reality: her country had few libraries, children did not read and she had a lot to contribute, she worked for years in a public library and motivated among the children the desire for recreational reading.
She knows the essential role that reading plays in instilling a love for learning and creating a brighter future for children and their societies, so she set out to find a different way for children to enjoy reading.
Investigating, Dr. Dajani realized that reading in company is different, that reading aloud impacts children much more and reading as a family is the key for them to find the magic key that opens the chest of knowledge and fun; finally, it is what she has done during her life as a researcher. Then, it was time to put her theory into practice and encourage children to read through 'We Love Reading'.
The model for this reading animation program is simple. The non-profit organization created by Dr. Dajani trains adult volunteers to read aloud to children in their community in an engaging way. Reading for yourself and alone is different from reading for many people who vibrate with the story of a reading around an entertainer who makes the moment fun and unforgettable.
Adults who want to be part of the program choose books in the children's native language and read aloud to them regularly in a public space. With this simple but powerful idea, 'We Love Reading' has now spread to 55 countries around the world, according to its creator.
When the process started, Dr. Rana felt it was important to measure the impact of reading animation, so she also invited other researchers to study what 'We Love Reading' generated among children.
"This simple model has proven to be highly impactful. The children began to enjoy reading and asking their parents to read to them; thus becoming change makers in their own homes," explains Dr. Dajani. "Additionally, the researchers found improvements in the children's cognitive abilities, empathy levels, a strength in their emotional intelligence, and increased prosocial behaviors, such as caring for the environment."
The volunteers who began to be part of the reading animation process became empowered, respected people and social entrepreneurs capable of finding solutions to the problems around them. Likewise, the community as a whole got closer and began to invest in similar projects generating a significant impact thanks to the construction of a social fabric that motivated the 'We love Reading' model.
According to Dr. Dajani, there are three keys to making reading animation a different and pleasant moment, as she stated in an interview given to Harvard University: "Start alone and read more so that you can become a role model for those around", explains the scientist. "Read to children in your workplace, community, or family for about 15 minutes a day and identify challenges in your own community, find the root of why children don't read, and then find a solution, no matter how small, put it into practice and move forward."
This is preceded by something much more important for the Jordanian scientist, "many children do not read all over the world because their parents do not read aloud to them, so through 'We Love Reading' we hope to educate a generation of creators of change." Reading to change the world, that is the key.
Previous PostGetting from crisis to systems change: Advice...
Next PostUNESCO International Literacy Prizes Jury mee...


Originally installed at Tanya Bonakdar Gallery (formerly Bonakdar Jancou Gallery), New York, this work transformed a section of the gallery into an exterior space. Walls were built around the skylight from floor to ceiling; the glazing was removed, and the floor paved with concrete tiles. Inside this newly created space, the walls were lined from eye level upwards with mirrors that reflected the rooftops outside. The installation opened the gallery up to the sights and sounds of the city around it – including the weather.


Pound the attacking zombie dolls with all your weapons arsenal! Protect the barricade at all costs, well, unless you want to be a zombie snack!
Use mouse to move and shoot. Use F to fix barricade, G to throw a cherry bomb, and space bar to change weapons.


The Lincolnshire Otter in Gainsborough is on Somerby Way, near Thorndike Way (A631). We're also handy for the A156, great for visitors coming from Everton, Glentham, and Messingham.
There is car parking available at The Lincolnshire Otter pub.


text:
Marian Schmidt (born in 1945 in Żyrardów, died on 7 March 2018 in Kraków) – Polish artist photographer. Member of Warsaw District of Polish Union of Artist Photographers (Związek Polskich Artystów Fotografików). Co-founder of Warsaw School of Photography and Graphic Design.

Biography
Marian Schmidt was born in Żyrardów shortly before the end of World War II. In 1946 - together with his family - he migrated to France and later to Venezuela - where he spent his childhood and attended high school. Later he graduated from University of California in Berkeley, USA and gained his PhD degree in mathematics (Brandeis University in Waltham, MA, USA). In 1974, he returned to Poland, where he worked for the magazines: Kino, ITD, Perspektywy, Szpilki, Teatr, Zwierciadło. In 1975 he worked as assistant to Polish film director Jerzy Kawalerowicz, as part of the film team Kadr. In the late 1970s he worked for some foreign photographic agencies: Black Star in New York, USA and Rapho in Paris. In 1980 he moved to Paris, and later - by mid-1990s - again to Poland. For numerous years he served as director and lecturer at the Warsaw School of Photography and Graphic Design. And also as lecturer at the University of Fine Arts in Poznań and National Film School in Łódź - where in 2002 he received post-doctoral degree (habilitation) in the discipline of artistic photography.

Marian Schmidt died on 7 March 2018 in Kraków. On 12 March he was buried at the Warsaw Jewish Cemetery at Okopowa street.

Art
Schmidt photographed since 1957. He was an author and co-author of numerous photographic exhibitions of individual and collective artists. His own photographies were presented in numerous places in the World such as New York, London, Paris, Tokyo, Zurich, but also in Poland: Kraków, Gdańsk, Poznań, Szczecin, Warszawa and also in his city of birth: Żyrardów. Special place in his art work was dedicated to humanistic photography, portrait as metaphore in a landscape. In 1995 he was accepted as member of the Warsaw District group of Polish Union of Artist Photographers (membership ID number 706).

His art works - photografies are in the collections of Bibliotheque National in Paris, Bibliotheques de l'Histoire Contemporainne in Paris, Musee de la Photographie in Charleroi (Belgium), Museum Folkwang in Essen (Germany) and in National Museum in Gdańsk, Poland.

Publications (albums)
His publications are the following:

 Hommes de science: 28 portraits (Paryż 1990)
 Marian Schmidt (Paryż 1994)
 Niecodzienne rozmowy z ks. Janem Twardowskim (Warszawa 2000)

References

Bibliography

 Leksykon kultury polskiej poza krajem od roku 1939 - Krzysztof Dybciak, Zdzisław Kudelski; Towarzystwo Naukowe Katolickiego Uniwersytetu Lubelskiego
 Zdjęcia polskiego fotografa z czasów PRL zachwycają na całym świecie. Teraz możesz je zobaczyć w Polsce.
 Założyciel Warszawskiej Szkoły Fotografii i Grafiki Projektowej dr hab Marian Schmidt.

2018 deaths
1945 births
20th-century Polish Jews
People from Żyrardów
Polish photographers
Polish expatriates in the United States
Academic staff of the University of Fine Arts in Poznań


text:
Home/Games/What Makes Games Fun?
GamesHealthSportsSwimming
While it is true that games are not reality, many of them can be compared to that. While there is a certain level of randomness involved, the result of a game is usually predictable, and chance has a less important role than rules. Games is an enjoyable form of entertainment and can have a variety of purposes. Here are some of the main types of games:
There are many different definitions of games. In Germany, a game is defined as any activity that is played for pleasure without a conscious purpose. Games are a form of entertainment, and they can include sports, puzzles, and arts and crafts. While these definitions vary, all of them are useful. There are many different definitions of games, and you should read them carefully to understand their meaning. Ultimately, they are not the same, but the basic principles remain the same.watch new video f95zone
In evolutionary terms, games have several different purposes. For example, games can help people signal their mate's quality. In the case of sports, they may even incubate physical and mental skills. In the case of computer-based games, the results are similar to cross-cultural studies. They can help people develop important skills, improve their health, and build social bonds. So, what makes a game fun? Let's take a look.new info here royalcbd
Game rules are simple, but their function is more complicated than that. In some cases, a game may not fulfill the intended purpose. Its activity is not only enjoyable, but it may also help people relax. In addition to its fun properties, games are also good stress relievers. So, if you're looking for a way to relieve stress and enjoy life's nuances, games are an excellent choice. They're not just for children anymore!
Are games considered entertainment? entertainment games at home gaming fun magazine How are video games a form of entertainment? video games are supposed to be fun video games as entertainment what causes a video game to be popular? what is electronic entertainment What is entertainment gaming? what makes a game what makes a good video game what makes a video game a classic what makes board games fun why do people think video games are fun
Easy Recipes For Birthday Party Foods
OPMS Kratom review:


text:
Here's your first official look at the OnePlus 7
OnePlus 7 has just been teased by founder and CEO, Pete Lau in a post on Twitter. Lau had earlier revealed April 17 as the date when he would reveal details about the next OnePlus product. All the details about the upcoming OnePlus product are encapsulated in the form of a 5-second video clip which Lau shared alongside a caption.
It reads, "Excited to share the next product from OnePlus will unleash a new era of Fast and Smooth. Especially Smooth! Smooth is more challenging than Fast – a true test of hardware and software. The new product is just beautiful – I can't wait for you to see it!"
"Fast and Smoooth"
The video shared by him focus on the term "Fast and Smoooth", but these are very generic hints to go by in the first place. We already know OnePlus is going to stay true to its philosophy of providing a slick experience and OxygenOS has time and again proven that claim.
A phone we believe to be the OnePlus 7 is displayed in the background of the video which when looked from a distance resembles the number 7. This indicates that the product CEO Lau is talking about is indeed the OnePlus 7.
If one looks closely at the picture, the edges of the phone seem to curve around the corners. This curve seems slightly more than what we have seen on the OnePlus 6T and it is quite likely that it'll have a fresh design.
The three o's in the word "Smoooth" could hint at a possible three camera setup on the OnePlus 7. The rumours surrounding the phone claim that the company will be introducing at least two variants of the OnePlus 7 and the high-end model could very well feature three cameras while the regular model may only have dual cameras.
Additionally, a recent report claimed that the OnePlus 7 Pro is going to feature an upgraded QHD+ resolution screen which has a 90Hz refresh rate. We might be reading in between the lines a bit more than usual, but if the OnePlus 7 Pro does happen to feature a display with 90Hz refresh rate, then it could corroborate with the teaser tagline "Fast and Smoooth".
Also Read: OnePlus 7 Pro leak points to a massively upgraded screen
Report says 20% of all 2018 web traffic came from bad bots


We want to translate AdBlocker Ultimate to all languages! Do you have some spare time and want to contribute to our project? Please sign up here with the language of choice (notice: you must be native speaker of the language).
Google Chrome is probably the most popular and trusted web browser today. As such it deserves a reliable partner against annoying and flashy ads, exactly what AdBlocker Ultimate is. It will help you get rid of all kinds of commercials on the Internet.
Firefox is a free and 100% open source browser available for almost all operating systems out there like Windows, OS X, Linux and Android, which supports add-ons. Add-ons are extensions to your web browser, designed to improve security or add additional features.
5. Voila and all annoying ads are GONE!
Opera is one of top 5 web browsers today. Just like Chrome, Firefox and others it supports extensions allowing users to improve privacy and security and even add additional features to your browser. If you enjoy Opera, but can't get rid of flashy ads, then it is time for you to install AdBlocker Ultimate.
4. Voila and all annoying ads are OUT!
Despite the fact that Internet Explorer has been replaced by Microsoft Edge on Windows 10, there are plenty of users still using it. Actually, it is still the second most popular browser today. Thus we developed AdBlocker Ultimate for Internet Explorer very precisely in order to deliver complete experience without annoying ads.
AdBlocker Ultimate for Safari uses the same codebase as the Chrome and Opera versions. So you can get the same ad-free web experience also on Safari. You can also be sure that once an update is released for Chrome or Opera, Safari will automatically get it too.
Yandex Browser claims to be a secure and anonymous browser, which keeps gaining more and more popularity. Just like other browsers it supports add-ons. AdBlocker Ultimate is the ultimate ad-blocking extension, you can get for Yandex.
5. Voila and all annoying ads are OUT!


text:
London laughs - forget the football, catch a comedy show in the Capital, Summer 2010
Posted: 28th June 2010
Let's be honest, it isn't just the football that's peed on our chips lately is it? Stiffer taxes, higher food prices and the 127th series of "My Family" is being recorded right in the middle of runway 2 at Heathrow during peak flying-time - ah well, we can but hope. Here then is a selective guide to some of the best comedy clubs in Central London, regular or irregular, and their upcoming gigs for the next few weeks or so.
All prices + booking fees. For ticket availability, click on the images, below, or scroll down for the full event listing.
Pear Shaped Comedy Club Not surprisingly, the middle of London houses dozens of comedy clubs but the main cluster is in and around the West End and Soho environs. Just outside the cusp of Oxford Street is The Fitzroy Tavern, home to the Wednesday Pear Shaped Comedy Club which is fast gaining a worthy reputation for cheap laughs (not literally, just financially) for £5 a pop. Compeers Brian and Krysstal attempt to stop the whole thing "go tits up". Next show is on the 30th.
Just The Tonic Comedy Club is situated in the Leicester Square Theatre and normally resumes performances on Fridays and Saturdays, with most evenings costing a tenner or less. Will Smith (the English version) appears this coming Friday and Saturday, Andrew Bird the following weekend (9th / 10th July) and Simon Lipson (16th) and Stewart Lee (17th) during the following weekend. Click on the venue name for further scheduled appearances at this club.
Boat Show Comedy Club If you fancy riding the high seas (oh OK, the Thames then) when having a chuckle, why not give the Boat Show Comedy Club a try? Situated near to Charing Cross BR / Embankment Tube, this floating world of comical nirvana (it's a boat) holds its performances on Fridays and Saturdays with four comedians, four bars and food available. The next night is on Saturday 3rd July for just £12.50.
Comedy Camp For something a little more niche, try the 'straight-friendly' world of Comedy Camp, based in the Barcode venue on Shaftsbury Avenue. Every Tuesday the very best in gay and straight comedians hit the mic including Zoe Lyons and Nick Revell (tomorrow evening), Shazia Mirza and Simon Happily on the 6th and Jo Caulfield and Robin Ince on the 13th. Tickets cost from £8, a bargain in anyone's world.
The London Comedy Club Finally, Cheeky Chappies might sound like a shop that sells baby-grows and three-wheeled buggies in Richmond, but was in fact a comedy club based at the Thistle Hotel in Coventry Street. Now it hosts the more obviously-named The London Comedy Club from Wednesday to Sunday every week and brings you a line-up that includes award-winning comedians, 3 for 2 drinks AND free admission to a selected nightclub in the area. Click on the link for further details.
We will feature clubs in the outer regions of London very soon! Happy clicking.
Monday, 28th Jun 2010
London: Comedy
UK: Comedy
JustTheTonicC...
Shazia Mirza
Feb 2020:On Sale This Week: The Weeknd, New Order, Alanis Morissette, Elton John, Dua Lipa, Ian Brown and more
Jul 2019:Fat Friday: Rammstein, Belinda Carlisle, Professor Green, Biffy Clyro, A Celebration of Talk Talk and Mark Hollis, Tokio Myers, BluesFest, Fontaines D.C. and more
The Week Ahead from Stevie Wonder, KISS, Groove Armada, k.d. lang, TRNSMT, Lovebox and other festivals, ZZ Top, Idles, Tom Jones and more
Jun 2019:The Week Ahead with Bon Jovi, Fleetwood Mac, Isle of Wight Festival, Download, Biffy Clyro, Nick Cave, The Courteeners, Garbage, Bryan Ferry, Pete Tong, Backstreet Boys and more


Carpet Beetles was posted in November 30, 2017 at 8:57 am. Carpet Beetles has been viewed by 394 users. If you want to use this wallpaper, please click the download link below to go to the download page. Right click the image and select "Save Image As" to download the Carpet Beetles to your computer or select "Set Desktop Background As" if your browser has that capability.
Carpet Beetles Learn Best Control Tips On How To Get Rid Of Carpet Beetle Bites!
Carpet Beetles Carpet Beetle Larvae What's That Bug?


Looking at Calculus Students' Understanding From the Inside-out: The Relationship Between the Chain Rule and Function Composition Publication: Horvath, A. (2008). Looking at calculus students' understanding from the inside- out: The relationship between the chain rule and function composition. In proceedings of the 11th Annual Conference on Research in Undergraduate Mathematics Education, San Diego, CA, Feb 29, 2008.
Lecture and Lab in a Biology Course for Non-Majors: Should the two go hand in hand?
How do outdoor and nature-based experiences differ between science majors and non-majors?


Posted August 15th, 2012 by va3isp & filed under News, UV920R.
So using this radio now for a few weeks I get the same complaint over and over. My audio is too low. Has anyone else looked into this or had this issue?
I spoke to Wouxun and their answer was the following.
I'll try it tomorrow and see if there is a difference. I would have thought the Noise Reduction was for the RX audio but we'll soon find out.
Did menu 41 fix the issue?
I had this problem, so I did a factory reset and it cured the problem.
Another one with the low audio output problem. I did a factory reset (after I had programmed the unit Grrr) and it helped. The audio level came up but is still lower than most radios. Otherwise, it seems like a nice unit.
I reset to factory mode, lost all my programming done, had no cable and had to reprogramme via the mic. The mic gain and oudio out is now as good as any other radio out there.