text:
Q: How to create this 2 layer pie chart in Excel 2010 Picture of Pie chart i need to create in Excel
Anyone know how to create this in Excel? I'm having trouble

A: Ended up using this method to create a donut chart instead: http://www.officetooltips.com/excel_2016/tips/using_pie_charts_and_doughnut_charts_in_excel.html


text:
Q: Doctrine 2 query builder vs entity persist performance Summary: which is quicker: updating / flushing a list of entities, or running a query builder update on each?
We have the following situation in Doctrine ORM (version 2.3).
We have a table that looks like this
cow
wolf
elephant
koala

and we would like to use this table to sort a report of a fictional farm. The problem is that the user wishes to have a customer ordering of the animals (e.g. Koala, Elephant, Wolf, Cow). Now there exist possibilities using CONCAT, or CASE to add a weight to the DQL (example 0002wolf, 0001elephant). In my experience this is either tricky to build and when I got it working the result set was an array and not a collection.
So, to solve this we added a "weight" field to each record and, before running the select, we assign each one with a weight:
$animals = $em->getRepository('AcmeDemoBundle:Animal')->findAll();

foreach ($animals as $animal) {
    if ($animal->getName() == 'koala') {
        $animal->setWeight(1);
    } else if ($animal->getName() == 'elephant') {
        $animal->setWeight(2);
    }
    // etc
    $em->persist($animal);
}
$em->flush();

$query = $em->createQuery(
    'SELECT c FROM AcmeDemoBundle:Animal c ORDER BY c.weight'
);

This works perfectly. To avoid race conditions we added this inside a transaction block:
$em->getConnection()->beginTransaction();

// code from above

$em->getConnection()->rollback();

This is a lot more robust as it handles multiple users generating the same report. Alternatively the entities can be weighted like this:
$em->getConnection()->beginTransaction();
$qb = $em->createQueryBuilder();
$q = $qb->update('AcmeDemoBundle:Animal', 'c')
            ->set('c.weight', $qb->expr()->literal(1))
            ->where('c.name = ?1')
            ->setParameter(1, 'koala')
            ->getQuery();
$p = $q->execute();

$qb = $em->createQueryBuilder();
$q = $qb->update('AcmeDemoBundle:Animal', 'c')
            ->set('c.weight', $qb->expr()->literal(2))
            ->where('c.name = ?1')
            ->setParameter(1, 'elephant')
            ->getQuery();
$p = $q->execute();

// etc

$query = $em->createQuery(
    'SELECT c FROM AcmeDemoBundle:Animal c ORDER BY c.weight'
);
$em->getConnection()->rollback();

Questions:
1) which of the two examples would have better performance?
2) Is there a third or better way to do this bearing in mind we need a collection as a result?
Please remember that this is just an example - sorting the result set in memory is not an option, it must be done on the database level - the real statement is a 10 table join with 5 orderbys.

A: Initially you could make use of a Doctrine implementation named Logging (\Doctrine\DBAL\LoggingProfiler). I know that it is not the better answer, but at least you can implement it in order to get best result for each example that you have.
namespace Doctrine\DBAL\Logging;

class Profiler implements SQLLogger
{
    public $start = null;

    public function __construct()
    {
    }

    /**
     * {@inheritdoc}
     */
    public function startQuery($sql, array $params = null, array $types = null)
    {
        $this->start = microtime(true);
    }

    /**
     * {@inheritdoc}
     */
    public function stopQuery()
    {
        echo "execution time: " . microtime(true) - $this->start;
    }
}

In you main Doctrine configuration you can enable as:
$logger = new \Doctrine\DBAL\Logging\Profiler;
$config->setSQLLogger($logger);

redpajama_set_name: RedPajamaStackExchange


Abstract—Insulation materials can play a significant role not only in supporting essential savings in operating costs but also in decreasing the environmental load of the building stock. This paper presents an integrated energy, cost and environmental life-cycle analysis for three types of insulation material [polyurethane (PUR), extruded polystyrene (XPS) and expanded polystyrene (EPS)] applied to a Portuguese reference building for single-family houses. The insulation materials were considered in external thermal insulation composite systems (ETICs). The seasonal calculation method was implemented to calculate operational energy. Life-cycle costing was employed following the net present value method. Alternative heating systems (heat pumps vs electric heaters) were assessed and a sensitivity analysis was performed to analyze the influence of the discount rate (5 and 7%) and building lifespan (30 or 50 years). The results of comparative assessment showed that the net present value gained by EPS along 50 years lifespan of the building was 16% more than XPS with the lowest value, and the required energy as well as global warming impact caused by XPS was approximately 9% more than PUR with the lowest value. The results also indicated that changing the heating system from electric heater to heat pump, decreased energy required for space heating by 10%, and increasing the discount rate from 5 to 7% caused the reduction of total net savings from 31% (EPS) to 41% (PUR). In addition, reduction of the building lifespan from 50 to 30 years decreased total net savings from 23% (EPS) to 28% (XPS). The results provide useful insight for building design decisions, energy management policies, etc., supporting the identification and prioritization of those parameters, in order to improve building performance.
Index Terms—Life-cycle assessment, life-cycle cost analysis, sensitivity analysis, thermal insulation material.
Seyedeh Shiva Saadatian is with the Mechanical Engineering Department of University of Coimbra, Portugal (e-mail: shivasaadatian@student.dem.uc.pt).
Fausto Freire is with ADAI-LAETA, Department of Mechanical Engineering, University of Coimbra, Portugal (e-mail: fausto.freire@dem.uc.pt).
Nuno Simões is with CICC - Construction Sciences Research Unit, Civil Engineering Department of University of Coimbra, Portugal (e-mail: nasimoes@itecons.uc.pt).
Cite:Seyedeh Shiva Saadatian, Fausto Freire, and Nuno Simões, "Comparative Life-Cycle Analysis of Insulation Materials in A Dwelling, Addressing Alternative Heating Systems and Life Spans," Journal of Clean Energy Technologies vol. 4, no. 6, pp. 462-465, 2016.


Here, ggplot2 is used to visualize US presidential election predictions using logistic regression on polling data.
First, the data is separated into a training set, containing data from 2004 and 2008 polls, and a test set, containing the data from 2012 polls.Then a logistic regression model is developed to forecast the 2012 US presidential election.
Now, let's develop a logistic regression model and map the prediction results.
To use ggplot2, predictions and state labels have to be in a data frame.
Now, we need to merge "predictionDataFrame" with the map data "statesMap". Before doing so, we need to convert the Test.State variable to lowercase, so that it matches the region variable in statesMap.
we need to make sure the observations are in order so that the map is drawn properly.
Now, we can plot the predictions.
We can play with the color, bourder thickness, line type and transparency.


text:
'Duke Nukem' Movie in the Works from 'Cobra Kai' Creators – The Hollywood Reporter
Duke Nukem, the 1990s video game that helped popularize the first-person shooter genre, is getting the feature film treatment.
Legendary Entertainment, the company behind Dune and the Godzilla monster movie series, has picked up the movie rights from Gearbox, with Cobra Kai creators Josh Heald, Jon Hurwitz and Hayden Schlossberg on board to produce.
Legendary will also produce, as will Jean Julien Baronnet (Assassin's Creed) of Marla Studios, which specializes on video game adaptations. Heald, Hurtwitz and Schlossberg are producing via their banner, Counterbalance Entertainment.
Launched with a self-titled debut in 1991 from Apogee Software, later called 3D Realms, Nukem is $1 billion video game franchise that began life as a platform game for personal computers. When the third game, Duke Nukem 3D, came out in 1996, it became not only a critical hit but one that helped usher in the ubiquity of first-person games for years to come. After laying low for years and stalled development, the franchise came back in 2011, after Gearbox acquired 3D Realms, with Duke Nukem Forever.
Nukem centers on its titular hero, modeled on certain attributes from 1980s action movies heroes (including catchphrases), who fights an alien invasion in Los Angeles. He travels from strip clubs and movie sets to moon bases and spaceships, dealing with mutated LAPD officers, women used in alien incubators, and the Cycloid Emperor.
A search for a writer to tackle the material is underway. And while no director is on board, the door is open for one of the Counterbalance team to potentially sit behind the camera.
With its over-the-top action movie stylings, it's no surprise that Hollywood has been trying to adapt the game into a feature for quite a while. Various indie producers have attempted to develop Nukem, though none got very far. Gearbox had a Nukem project in development at Paramount with John Cena attached to star over four years ago, but that stalled out.
That led Gearbox to become more deliberate in its Hollywood strategy for adaptations of its video games and it now has one already on deck: Borderlands, directed by Eli Roth and featuring an all-star cast including Cate Blanchett and Kevin Hart. Lionsgate is the behind the movie which is expected to be released later in 2022.
The Counterbalance trio made a name for themselves by first writing then later directing the Harold & Kumar comedies and taking over the American Pie franchise. They re-imagined The Karate Kid for a new generation with Cobra Kai, a runaway hit for Netflix that also garnered numerous Emmy nominations. Heald, Hurwitz and Schlossberg are the creators, executive producers and showrunners of the series, writing and directing many of the episodes.
Counterbalance is repped by CAA. Heald is additionally repped by Behr Abramson while Hurwitz and Schlossberg are repped by Hansen Jacobson.
Made for Love Canceled After Two Seasons at HBO Max
Break Your Overnight Fast with These Breakfast Cookbooks
Climate change: UK government admits its net zero strategy doesn't add up
Elon Musk Getting Twitter Fire-Hose Data Raises Privacy Concerns
Don't Trust Your Gut review: Can big data really improve life choices?
LWLies' favourite line readings of 2022
"No Way Elon Musk Is Going to Buy Twitter…A Company Largely Based on BOTS and Spam Accounts" President Trump on Elon Musk's Twitter Deal
NYC's Covid Policies Drove Wealthy Residents — And Their $21 Billion — To Other States
DALL-E 2: OpenAI art tool seems to covertly add words to increase diversity
Netflix, ESPN, and NBCUniversal compete for U.S. Formula 1 rights, report says – TechCrunch
Kanye West and XXXTentacion's "True Love": Stream
Watch Winter Follow-Up to Explosive K-Pop Debut – Billboard
Low back pain: How over-the-counter medicine might be making it worse

redpajama_set_name: RedPajamaCommonCrawl


0%100°74°Night - Clear. Winds E. The overnight low will be 75 °F (23.9 °C).Sunny with a high of 100 °F (37.8 °C). Winds variable at 1 to 8 mph (1.6 to 12.9 kph).
Tonight - Clear. Winds E. The overnight low will be 75 °F (23.9 °C).
Today - Sunny with a high of 100 °F (37.8 °C). Winds variable at 1 to 8 mph (1.6 to 12.9 kph).


Quickly fold and insert your letters and paper into envelopes by using an automatic envelope-stuffing machine from Formax. This equipment, sometimes called folder inserter machines, is automated and saves hours of time and money by automating a process that takes people hours to do. Our envelope stuffing machines / folder inserters come in a variety of formats and designs, depending on your monthly volume and the amount of sheets that need to be inserted.
Variations of our folder inserting machines include single, double, triple folding and inserting. Many of our machines can even handle more than 3 sheets of paper. Most of our folder inserters also offer the capability to place inserts and smaller BREs (business reply envelopes) into envelopes. This is perfect for mailing invoices, bills, bank statements and more. If needed, we also offer many leasing options on our machines. Lock in this great price and buy your Formax envelope-stuffing machine today!
Description: If you're in the market for an affordable paper folding and envelope-inserting machine, the Formax FD 6102 is a great option. This tabletop unit sits on the edge of a table and pulls single or multiple sheets, folds them, puts them in an envelope and seals the envelope shut. Order yours today!
Description: The FD-6404 is an envelope inserting machine, designed to take your letters, invoices and other material, fold them and insert them into an envelope. This machine takes what would take hours and completes it in just minutes. It even seals the envelopes shut.
Description: Are you in need of a high-capacity paper folder inserter? The Formax FD-6304 may be just what you need. This automatic envelope stuffing machine is extremely user friendly and is available in several variations, depending on what your needs are. Options and variations include high-capacity vertical stackers, OMR / BCR readers, compatibility with MailDoc software, different types of feed trays and much more.
Description: The Formax FD 6400 series adapts for almost any folding and inserting application. Several models are available to meet your folding and inserting needs. The FD-6400 STD 2 folder inserter is capable of inserting up to two documents at a time.
Description: The Formax FD 6400 letter inserting machine will fold paper, insert it into an envelope and seal it shut. The entire process takes just seconds. This is significantly faster than manually folding and inserting mail.
Description: This machine is available with anywhere from 2-6 feeding stations, depending on the model you require. It can half fold up to 10 sheets of paper at a time and tri fold up to 8, making this machine an impressive product to have in the mailroom of any office that sends out checks, invoices, letters and other documents.
Description: The Formax FD 6400 series adapts for almost any folding and inserting application. Several models are available to meet your folding and inserting needs. The FD-6400 6 folder inserter is capable of inserting up to four documents at a time.
Description: The new Formax FD-6402 folder inserter is designed to quickly and efficiently fold and insert paper into envelopes. The FD-6402 Standard and Special both have to input trays. The Standard has two paper trays and the Special has a standard tray and a special tray capable of handling glossy paper.
Description: If you are folding and inserting mail, and need a machine with the ability to insert glossy, slick and coated paper, you probably need a machine like the Formax 6404 envelope inserting machine with special feeders. This machine handles most types of paper.
Description: The Formax 7100 advanced folder inserter is an ideal machine for creating professional mail pieces in minutes. It is available with up to nine feed stations and can be used for almost all mailing purposes. The motor on the FD-7100 series runs at a speed of 4,500 pieces per hour and has a duty cycle of 150,000 pieces per month.
Description: The model Formax FD 6600 folder inserter can adapt to nearly any folding and inserting application. Two, four and six station models are available to meet your particular needs. The Formax 6600 Series offers two output systems: a power stacker, which holds up to 500 filled envelopes, in their original order; and a side exit tray which holds up to 250 filled envelopes.
Description: The versatile 6606 Series adapts to most any folding and inserting application. Models are available with 2-7 stations, offering the flexibility to meet your specific needs. A variety of input configurations includes a high-capacity document feeder for up to 725 sheets, 1 or 2 high-capacity production feeders, standard and special feeders, and short feed trays.
Description: The Formax FD 6600 automatic folder inserter has a total of 6 stations, allowing it to quickly fold and insert multiple sheets of paper into an envelope.
Description: Our line of Relyco Model 44 envelopes measure in at 3-7/8" x 8-7/8" and feature a #9 envelope size with a single window. These are perfect for a variety of mailing applications. The inside of this envelope is coated with a security tint, making contained material impossible to read.
Description: Save your business money by getting your #10 envelopes from ABC Office! These Relyco Model 58 envelopes are perfect for daily use and will get your mail to its recipients in tact. These envelopes work great with Formax envelope stuffing machines. Designed with quality in mind, this envelope includes a security tint that protects contained documents from unwanted viewing.
Description: Our Model 60RF Relyco #10 envelopes are prefect for mass mailing and work great with Formax folding and inserting machines.
Description: Our Relyco Model 45 envelopes are made from quality materials and designed to handle mailing without falling apart. This envelope measures in at 3-7/8" x 8-7/8", which is a #9 size envelope. This envelope features two windows. The inside of this envelope is coated with a security tint that prevents unwanted viewing of pre-opened contents.
Description: Do you need a high-quality #10 envelope that can handle the mailing process? You should seriously consider using our Relyco Model 59 envelope. This envelope is ideal for use with Formax folding and inserting machines and includes 2 windows.
Description: If you need a #10 envelope that has two windows that is also compatible with folding and inserting machines, you may want to consider using our Relyco Model 61RF envelope. This envelope measures 4-1/8" x 9-1/2" and is designed to not only be affordable, but also extremely durable. The #61RF also includes some high-end security features such as a lined security tint and windows designed to conceal MICR information.


Beautiful waterfront home with open floor plan that is located in the gated community of the Waterfront East. Kitchen and living room have high ceilings and and large windows that look out to the waterfront fringed with cyprus trees. The Kitchen has a large tri-angled two tier island perfect for high bar stools. Living room has a beautifully sculpted fireplace and a large impressive beautifully custom built and stained entertainment center. Master bedroom has large windows that look out toward the waterfront. Master walk-in closet has custom built-in cabinets and drawers. This home has a total of three bedrooms and three and a half baths, the half bath conveniently located out back. Large bonus room with double glass doors can be used as a formal dining room, a large office, entertainment room, or a fourth bedroom. Backyard has concrete patio space for entertaining. There is a nice size pier and a boat slip with 12,000lb lift. This home is a must see.


Human beings are habit-creating machines, craving any mental or physical shortcut that lets us focus on higher-level thoughts, such as what's for lunch or developing theories about Netflix dramas.
Bad money habits are more difficult to steer out of than other automated behaviors like driving a car. Why? Financial peace of mind is a much more subtle reward than the satisfaction of navigating a half-ton piece of metal through city streets without death or injury.
Still, every person who is good at money learned good habits, which means you can, too. "What we know from lab studies is that it's never too late to break a habit. Habits are malleable throughout your entire life," Charles Duhigg, author of "The Power of Habit," told NPR.
Here are seven financial habits you should break before you go broke.
Who do you think you are, the U.S. government? America's fiscal deficit is projected to be $559 billion in fiscal year 2017, according to the Congressional Budget Office.
How is your own personal deficit? About one in five Americans spend more than they earn and 38% break even, research from the National Financial Capability Study shows. Your goal must be to join the 40% of Americans who spend less than they earn.
Here's how not to handle your obligations: When a collection agency calls, you pay the bill. This kind of financial firefighting only guarantees you'll veer from crisis to crisis as your credit score burns.
Payment history carries huge weight on your financial future; more than one-third of your credit score is judged by your ability to pay your power bill, car insurance and credit cards on time. If you can't, work out a payment plan with your creditor before it goes to collections.
Credit cards are a weapon in your financial arsenal. Like all armaments, they can be used in strategic defense or to shoot yourself in the foot. Too often, it's the latter — the average U.S. household with credit card debt has $16,748 of it.
That plastic in your pocketbook is the greatest enabler of bad money habits, allowing you to spend on a whim and forsake all budget plans. Sticking to a budget should be your most faithful money habit.
Today, consumers must take control of their own financial lives, whether it's understanding health insurance or guiding their own 401(k) plans to invest for retirement. Even so, during the rollout of the Affordable Care Act, many consumers struggled to understand basic health insurance terms such as "deductible," a survey by the Kaiser Foundation found.
Learn the lexicon of finance to manage your money better.
"I used to catch myself saying, 'Investing is hard. I just don't understand it.' This gave me permission to avoid learning how to invest," wrote Ann Marie Houghtailing, author of "How I Created a Dollar Out of Thin Air." "Now I say, 'Investing is a skill. You just have to start small.'"
Old habits die hard, and one of the oldest habits is using checks to pay bills or make savings deposits. "Personal finance habits take longer to change than the way you might switch from one smartphone to another. That's because money is so important to us," Fred Davis, a professor of Information Systems at the University of Arkansas, told Marketplace.
Set up automatic transfers for bill payments. Also automatically have 10% or more of your paycheck sent directly to your savings account. These two steps will go a long way toward building good money habits and credit scores with little effort.
Whatever energy you're spending complaining about the size of your paycheck takes energy away from finding ways to improve your bottom line. Think you're being underpaid? Negotiate a raise or at least talk with your boss to understand what's needed to see a bump in pay. If you're valued, your supervisor will see the implicit threat that you may leave for a higher-paying job. Start looking for that more lucrative gig while you're at it.
In the meantime, investigate ways to build other streams of income and seek ways to improve your skills.
OK, money does bring happiness, but only to a point. Purchasing experiences and giving to charity have a much longer shelf life for our well-being, research suggests.
Breaking your go-to financial routines will take time and effort. Subbing in habits that improve your bottom line — paying bills on time, using technology and increasing your income and savings — will be worth the work in the long run.
The article 7 Bad Financial Habits You Need to Break Right Now originally appeared on NerdWallet.


Keep it light; a 'jazz-waltz' lilt will add to the enjoyment of the singers (be they choir or congregation). It's hard to sing this without moving, smiling, and… yes, actually laughing! Try laughing a 5th verse. Some may be more comfortable using 'laugh-words' on the melody, but those who can REALLY laugh should just cut loose!
The emotions which bring us laughter and tears are closely linked. "Give To Us Laughter" is frequently sung at funerals and memorial services as well as at times of joy.


According to a statement issued by World Health Organization, A successful and cost-effective intervention for public health which can prevent approximately 2.5 million children from dying every year is vaccination from whooping cough, tetanus, diphtheria, and measles.
In this 21st century there is a lot of information available from different sources with the main source being the Internet. Therefore, it is important to investigate the credibility of every source of information especially those of sensitive issues like immunization.
Breakthrough in medical science has led to an increase in the number of vaccines meaning your child can now be prevented against more diseases. In the past years, some diseases killed thousands of children but have nowadays been eliminated, and others are almost going extinct. Example of these is Polio. The paralyzing disease was once the most-feared disease but thanks to vaccination because nowadays there are no cases of the disease.
Smallpox is another example of a disease that has been eradicated worldwide.Our children don't have to suffer from the disease again because it no longer exists. Thanks to, firstly, vaccination for the great accomplishment. Secondly, to the earlier generation for accepting to use the vaccine and eradicate the diseases. It is glad to know that not only are we preventing ourselves from diseases but also future generations.
Every vaccine product is only given to children after a careful review by medical doctors, scientists and health care professionals. Like any other drug, there is little discomfort like tenderness and pain at the site of injection.
· Prevent two hundred thousand (200,000) cases of death.
·Prevent death of at least 49,000 children who die of neonatal tetanus.
These cases are a clear illustration of the impact of immunization on children health across the globe.
Did you know that in some countries children with a vaccine-preventable disease can be denied school or children facilities attendance? The measure is taken to curb the spread of the disease. Some vaccine-preventable illness can lead to disabilities.
These children require specialized attention from parents and siblings consuming time that could be used to engage in economically productive activities.
Additionally, diseases from vaccine-preventable diseases increase the medical bills of the family which can be avoided. Parents should utilize children vaccination programs because they are federally funded programs that provide the services at no cost mostly to children from humble backgrounds.


text:
High Burst
China built the first electric car designed exclusively for ride-hailing
November 28, 2020 November 27, 2020 homepinsinfo
Two of China's top companies have joined forces to design, develop, and build an electric car for the express purpose of ride-hailing.
The vehicle is an adorable green hatchback called the D1, and it was developed by Didi Chuxing, the top ride-hailing company in China that notoriously defeated Uber in 2016, and BYD, one of the leading electric vehicle manufacturers. The D1 will have a range of 418 km (260 miles) as judged by NEDC (New European Driving Cycle). They also explained some of the more interesting design touches that make this vehicle particularly well-suited for app-based ride-hailing.
There is a medium-sized screen on the dashboard as well as two more touchscreens on the back of both headrests for passengers to access navigation and other information. There is one more smaller screen behind the steering wheel that serves as an instrument cluster.
The car comes with sliding doors to prevent riders from accidentally hitting passengers or cyclists. The driver's seat is extra comfy for extended use, and there's added legroom in the back seat. The paint job is described as "avocado green," which is similar to Didi's shared bikes.
The D1 will come with a Level 2 driver assistance system that includes lane-departure warning, automatic braking, and pedestrian collision warning. There will also be a driver monitoring system to ensure that drivers keep their hands on the wheel and stay focused on the road.
According to automotive journalist Greg Kable, the five-seater D1 will feature a 136bhp (100kW) electric motor and lithium-ion battery from BYD's Fudi factories in Chongqing.
The two companies started working together on a vehicle design project two years ago. Didi is one of the largest ride-hailing operators in the world, and it claims to deliver 10 billion trips a year. BYD is one of China's leading EV manufacturers.
Didi says it used data gathered from its 550 million registered passengers and 31 million drivers to design the D1. "To ensure a reliable and more cost-effective supply for its drivers' network that today delivers as many as 60 million trips per day, DiDi China has been building a deeper automotive ecosystem for its core mobility service by establishing an extensive alliance with manufacturers, energy providers and other industry players in the value chain," the company says.
Automakers have designed cars for commercial taxi services for decades. New York City's "Taxi of Tomorrow" is a Nissan NV200 that notoriously only lasted seven years before losing its exclusive deal. London's iconic black cabs are designed and built by a company called the London Taxi Company. That company was bought by China's Geely in 2015 and now makes electric cars.
Uber and Lyft have both made moves to increase the number of EVs available on their app. Didi says it has "about 1 million" electric cars on its platform today.
UK weather: Met Office forecasts North-South rain divide before 'rather cold' end to week
Virgin Money sinks to loss after putting £500m aside for bad loans
Why Others Don't Take You Serious
Between the Links: Deiveson Figueiredo, UFC 255 fallout, AJ McKee's Future, Mike Tyson vs. Roy Jones
Act now to meet global heart disease targets
Taxpayer faces £40bn bill as cost of emergency loan schemes soars
Tanooki Mario will be available in Lego form next year


text:
La  du Tour des Flandres a eu lieu le . C'est la huitième épreuve de l'UCI World Tour 2015.

L'épreuve a été remportée lors d'un sprint à deux par le Norvégien Alexander Kristoff (Katusha) devant le Néerlandais Niki Terpstra (Etixx-Quick Step) et sept secondes devant le Belge Greg Van Avermaet (BMC Racing).

Présentation
Ce Tour des Flandres est la troisième des quatre classiques flandriennes inscrites à l'UCI World Tour ainsi que le deuxième monument après Milan-San Remo. La course se déroule une semaine après Gand-Wevelgem et une semaine avant Paris-Roubaix.

Parcours
Le parcours a été dévoilé le . Avec , il s'agit de la plus longue édition depuis 2001.

Dix-neuf monts sont au programme de cette édition, pour la plupart recouverts de pavés :

En plus des traditionnels monts, il y a six secteurs pavés répartis sur  :

Équipes
Vingt-cinq équipes participent à ce Tour des Flandres - dix-sept WorldTeams et huit équipes continentales professionnelles :

Règlement de la course

Primes

Favoris
En l'absence des deux gros favoris, le Belge Tom Boonen (Etixx-Quick Step) et le Suisse Fabian Cancellara (Trek Factory Racing), l'édition 2015 du Tour des Flandres est bien plus ouverte que les précédentes. Ainsi, la liste des vainqueurs potentiels s'est considérablement élargie, avec la présence du Slovaque Peter Sagan (Tinkoff-Saxo), du Tchèque Zdeněk Štybar (Etixx-Quick Step) et de son coéquipier le Néerlandais Niki Terpstra, du Belge Jürgen Roelandts (Lotto-Soudal), auteur d'un échappée en solitaire sur les routes de Gand-Wevelgem une semaine plus tôt, du vainqueur du Grand Prix E3 le Britannique Geraint Thomas (Sky) ainsi que du vainqueur de Gand-Wevelgem, l'Italien Luca Paolini (Katusha) et son coéquipier le Norvégien Alexander Kristoff.

Récit de la course

Classements

Classement final

UCI World Tour
Ce Tour des Flandres attribue des points pour l'UCI World Tour 2015, par équipes uniquement aux équipes ayant un label WorldTeam, individuellement uniquement aux coureurs des équipes ayant un label WorldTeam.

Classement individuel
Ci-dessous, le classement individuel de l'UCI World Tour à l'issue de la course.

Classement par pays
Ci-dessous, le classement par pays de l'UCI World Tour à l'issue de la course.

Classement par équipes
Ci-dessous, le classement par équipes de l'UCI World Tour à l'issue de la course.

Liste des participants
 Liste de départ complète

Notes et références

Liens externes

    Classement final sur le site de l'organisateur
  Classement final sur le site de l'UCI

2015
Cyclisme en Belgique en 2015
Cyclisme sur route en 2015
Cyclisme en avril 2015
Sport en Belgique en avril 2015

redpajama_set_name: RedPajamaWikipedia


text:
Volume 27, No. (5), 2017, October
(Impact Factor 0.381; JCR 2016)
Peste des petits ruminants in Algeria: Viral circulation of PPRV between 2012 and 2015
R. Baazizi1, D. Khelef1 and T. Hussain*2
1National Veterinary Higher School, ENSV/BP 161 Hacène Badi, El- Harrach, Algiers, Algeria
2Department of Molecular Biology, Virtual University of Pakistan, Lahore
*Corresponding author's email: tanveer.hussain@vu.edu.pk
Following the detection of lineage IV peste des petits ruminants virus (PPRV) circulation in Tunisia and Morocco in 2008, investigations were regularly executed in farms and livestock markets of Algeria, mainly in western and eastern part bordering Morocco and Tunisia, respectively. A sero-surveillance undertaken in early 2011 confirmed serologically positive cases in the Sahara desert region. Consequently a national sero-survey of PPR involving all the 48 administrative districts of Algeria was conducted in February 2012, from 13/02/2012 to 23/02/2012. A total of 3396 samples from 202 livestock herds spread over 48 administrative districts (Wilayas) of Algeria were collected for this purpose. Serum samples were tested for the presence of antibodies to PPRV following the competitive ELISA protocol (cELISA). The laboratory investigation revealed a very high rate (68.8%) of serologic prevalence of PPR at national level. It also showed the spatial variability of the prevalence between different regions in the country; the highest infection rates (86.8%) were registered at the west region bordering Morocco while the lowest (51.4%) was observed in the north. This rate also varied from old animals (22.9%) to young animals (13.5%) and from goats (23.9%) to sheep (17.1%) and from females (21.8%) to males (14.1%). The PPRV circulation is proven towards this survey but none vaccination program was applied. It is in this purpose that a sero-survey was lead in 2015 where 1286 animals were sampled (1085 sheep and 201 goats), 315 were positive with a global seroprevalence of (24.5%). The seroprevalence calculated in sheep is (24%) and (26%) in goats. This lead to implement the strategy to fight PPR as the veterinary services decided in 2013 that vaccination will be extended to other districts based on the results of the serological survey and changes in health status.
Keywords: Peste des Petits Ruminants, morbillivirus, seroprevalence, sheep, goat, Algeria.


text:
About Us V1
More than 10,500 people across 140 jobsites celebrated National Construction Safety Week and participated…
Roaden Makes $20,000 Investment in Safety
Category: Our services
Roaden Wins An Engineering Analysis Project
By admin1Gallery, Our company
Roaden, a global provider of design engineering and master data management services, has been awarded an engineering analysis project. Following the Games, the area will be transformed into the mixed-use…
CertificationsOur services
By admin1Career, Certifications
Built by Roaden this staggering project included the construction of seven new mid-rise buildings on the 35-acre West Don Lands site. The Games, the area will be transformed into the…
Roaden is a diversified construction company, made up of teams of people who are proven in their industries. All working to design, build, transport, operate, and maintain projects all over the USA.
Working Time: Mon–Sat:
© 2021 The Funding Process. ,Inc and Web Templates Ltd. All Rights Reserved. Privacy Policy


text:
Brain scans strongly predict return of consciousness in vegetative patients
Brain glucose metabolism shows a dramatic drop from full consciousness to the minimal conscious and persistent vegetative states. Stender et al.
A simple measurement using a device available in every hospital could distinguish brain damaged patients who are likely to "wake up" from those who are not, scientists reported on Thursday.
Predicting which unconscious patients will remain that way forever and who is likely to recover is so difficult that even expert physicians get it wrong in about 40 percent of cases, said Dr. Nicholas Schiff of Weill Cornell Medical Center in New York City, who was not involved in the new study.
As a result, tens of thousands of patients are discharged from hospitals and "shunted off to nursing homes and other institutions" where they are treated as living corpses, kept alive but given no therapy that might bring them back to conscious life, Schiff said.
The new study, which he called "rigorous and extremely well done," offers a "direct, simple approach that could be adopted tomorrow."
An estimated 200,000 to 300,000 people in the United States are living in that gray area between life and death — either in an unresponsive wakefulness state (previously called a vegetative state) or a minimally conscious state. In the former, people look awake but are wholly unaware of their surroundings and do not consciously respond to sights, sounds, or touch. Those in a minimally conscious state sometimes respond to a command or other stimulus, but often do not — hence the difficulty in distinguishing the two. But the latter are much more likely to regain consciousness.
Watch: Episode 3: Scientists are building mini-brains to understand the human mind
Diagnosing via behavioral measures is "susceptible to interpretational bias," said Ron Kupers. So he along with colleagues at the University of Copenhagen set out to "find more objective measures" to distinguish these two states. They used positon emission tomography, or PET, imaging, which measures brain metabolism, to try to distinguish brains that appeared equally unconscious but that might have different capacities for recovery.
The scientists tested the technique on 131 brain-injured patients: 49 in a vegetative state, 65 who were minimally conscious, and 17 who were emerging from a minimally conscious state. No single region was associated with likelihood of regaining consciousness — that is, the brain does not have a "consciousness center."
But overall metabolism did show a difference. Vegetative patients had, on average, 38 percent of the brain activity that healthy people did. Minimally conscious patients had 56 percent, the researchers report in the journal Current Biology.
The technique missed only 5 percent of the minimally conscious patients (in statistics-speak, it had a sensitivity of 95 percent). It incorrectly identified as minimally conscious only 22 percent of patients who weren't (its specificity was 78 percent).
Especially compared to how physicians currently make that distinction, said Cornell's Schiff, "that's good enough for prime time."
Arguably even more important, PET predicted whether a patient would recover awareness within a year. The cutoff: Brain activity at least 41 percent of that in healthy people. Using that rule of thumb researchers correctly identified 94 percent of the patients who would recover within 12 months.
Does exercise keep the brain young?
That suggests that at a high enough metabolism, the brain flips from one fundamental state (unconsciousness) to another (consciousness) rather than changing gradually.
A previous study by some of the same researchers had found that PET scans could correctly predict regained consciousness 74 percent of the time. This study improved upon that rate.
And this new, more precise metric holds much more promise for patient care. Expert panels have repeatedly called for wholly or partly unconscious patients to be reevaluated every few weeks to see if they might be regaining awareness. But most insurance plans don't cover that, said Schiff, so it doesn't happen.
The new study "takes away the argument that we don't know," Schiff said. "It's a game changer."
In LA, ambulances circle for hours and ICUs are…
In LA, ambulances circle for hours and ICUs are full. Is this what Covid-19 has in…
Trump administration will let nearly all doctors prescribe addiction…


Mas Q Menos was created to bring Spanish gastronomy to everyone at affordable prices in a laid-back and friendly atmosphere, combining traditional flavours with the comfort and speed required today. The ethos of these family-run restaurants is all about quality and authenticity of ingredients, priding themselves in leading the field in providing first class regional produce.
A link to Mas Q Menos on Fluid London has been sent.
Edit the information we hold on Mas Q Menos or learn about upgrading today.


Pait's Tractor has been locally, family owned, and operated since 1990. June 9th of 2010 will mark our 20th anniversary. We offer friendly, down-home service. You'll always see many of the same friendly faces no matter when you visit or how many times you come to see us. We always have our doors and hearts open to our customers no matter what the circumstances may be. We are confident that we can answer questions to the best of our ability. Also we can help fix or sell anything that you may be interested in. So come on down to see us!!!


Innovation never sleeps and we're thrilled to bring you the first two firmware updates of this year. This time, our product updates are filled with advances in security, improvements to the existing features, and new support for long awaited coins. We are happy to announce that Ripple (XRP) is now available to be stored in Trezor Model T.
In order to fix the security vulnerability announced in December, we have updated the way that Trezor One stores data so that it follows the more advanced, secure procedure followed by Model T. We are also currently in the process of backporting the modern, flexible, and functional code architecture from Model T to Trezor One, to ensure that Trezor One will always remain fully up-to-date.
In addition to technological advancements, we're also announcing new additions to the list of supported coins for Trezor One. From now on a new pack of ERC-20 tokens, including some of the best-known cryptocurrencies such as Komodo, PIVX, or NIX, are available on Trezor One.
The developers of the newly added coins are now free to integrate Trezor with their wallets so you can store more of your favorite cryptocurrencies in the original Trezor One.
The main news for Model T is definitely the coin listings. One of the biggest and best-known projects – Ripple – is now available in the Trezor Wallet interface, and you can store, send, and receive Ripple by using nothing but the Wallet. Ripple is currently only available in the Beta Wallet.
But that's not everything; our Wallet now contains a new tab that has moved from Beta Wallet to our official Trezor Wallet. This tab allows you to buy cryptocurrencies by using your debit or credit card, and users based in Europe are able to use SEPA wire transfer as well. With 10 available exchanges to use you will be able to find the best market price available.
In addition to these updates, our teams implemented new security improvements to make sure your coins are protected at all times. If you would like to learn something new and read more about the technical details or these two updates, please read our security blog post. And if you're a tech-savvy power user we would love to read our Dev Corner article about the latest firmware updates.


The best time to buy airplane tickets is Wednesday morning at 1am, but if that specific slot doesn't work for you, then stay up late and purchase airfare when everyone else is sleeping so you get a great deal.
"When I checked the airfare prices at 1 p.m., the ticket was more than $600," Payton recalls. After staying up all night, she checked prices again around four in the morning and saw that the ticket price had dropped significantly. "It went from $600 to $287," Payton notes. Ever since, she says she frequently finds much cheaper airfares when everyone else is sleeping.
Check out the full post at Open Forum for other great advice on how to travel on a business trip. But if you're heading out just for a day, then our professional's guide to a day trip is more up your alley.


In partnership with Kenyon Energy, Maui Electric Company is pleased to announce that Maui's second large-scale solar PV project came online Oct. 4, 2018. Maui Electric is buying power from the Ku'ia Solar project in West Maui which is independently owned and operated by Kenyon Energy.
The 10.85-acre project, located on land owned by Kamehameha Schools in Lahaina, can offer up to 2.87 MW of solar power to Maui Electric's grid at 11.06 cents per kilowatt-hour. Maui Electric does not mark up or take a profit from this purchased power, passing the savings directly to Maui customers.
Financing for Kenyon Energy's South Maui project was provided by Key Equipment Finance through its Energy Solutions team. Maui Electric is also purchasing power from another Kenyon Energy project, South Maui Renewable Resources, which came online in May. Bay4 Energy has been selected to provide ongoing asset management and operating services for both projects while M+W Energy served as the EPC provider for both projects.
Currently, Maui County has a renewable energy portfolio of 34% – ahead of the state's target of 30% renewable energy by 2020. On some days, a significant portion of the electricity used on Maui comes from large grid-scale and privately-owned renewables, such as wind, hydro, biofuels, and nearly 12,000 rooftop solar systems. In June 2017, Maui Electric reached a peak of 77% of its power coming from renewable energy resources.
Founded in 1887 by Princess Bernice Pauahi Bishop, Kamehameha Schools is a private, educational, charitable Native Hawaiian trust committed to improving the capability and well-being of our people through education. Income generated from its endowment portfolio of commercial real estate and other diverse investments funds more than 96 percent of KS' educational mission.


Indian actor known best for his role as Vikram Arun Rathi on the Indian Star Plus soap opera Diya Aur Baati Hum. He went on to compete on the eighth season of the Colors TV reality series Bigg Boss.
He made his television debut in the Zee TV soap opera Kasamh Se.
He and Sushant Singh Rajput co-starred in a 2015 film based on the life of professional cricket player Mahendra Singh Dhoni.
A native of Delhi, India, he attended Hansraj College, Delhi University.
He and Deepika Singh were both series regulars on Diya Aur Baati Hum.


The Taormina Family extends thank you's to the Anaheim community for the show of support at the recent passing of their mother, Arlene Taormina.
Arlene was the matriarch of the Anaheim family that built the Anaheim Disposal Inc. company and has been serving the city for over 50 years. Arlene was involved in the community in a variety of clubs of organizations including Guardian Angels of Anaheim Memorial Medical Center, Women's Division of Anaheim Chamber, Sons of Italy, Anaheim Lions Club, and more.
Sons Bill and Vince Taormina and daughter Arlene plus over 300 community members, friends and family heard stories of Arlene's beginnings in Anaheim from her twelve grandchildren who each spoke about their grandmother.
Donations to the memory of Arlene Taormina can be made to Boys & Girls Club of Anaheim, 311 East Broadway, Anaheim, 92805 or the Anaheim Family YMCA, 240 S. Euclid Street, Anaheim 92802.
Congratulations to the honorees for the Women's Division of the Anaheim Chamber of Commerce Annie Accolades Awards, held on Thursday, March 22 at the Holiday Inn at Walnut St. & Ball Rd. Wilma Ast, Sandra Barry, Marge Conway, Debbie Herman and Leslie Kazarian were recognized by the Women's Division for their volunteer spirit and community commitment in service to Anaheim.
Each in her own way has served the community through work with Girls Scouts, Ebell Club, Anaheim City Schools, Anaheim Sister Cities and many more organizations. Each honoree was escorted by VIP escorts Mayor Pro Tem Bob Hernandez, Anaheim Chamber President and CEO Todd Ament, Anaheim Chamber Board Chairman Margaret Pashko, former Anaheim City Councilwoman Shirley McCracken and Alden Esping, representing the Chamber Ambassadors. Carol Latham chaired the event and was supported by committee members Phyllis Boydstun, Lynda Visser Nath, Martha Rosmus, and Martha Snook.
Volunteers are needed during the City of Anaheim's Always Fresh Fest April 13-14, 2007. In celebration of the 150 anniversary of Anaheim, Neighborhood Services is hosting the Neighborhood Clean-up Campaign from 9:30 a.m. to 2 p.m. on Saturday, April 14 at a variety of neighborhood sites. Throughout the event, Neighborhood Services and Anaheim 150 will be facilitating activities and distributing informational material that will help enlighten the community about free public services provided by the City to help keep Anaheim beautiful. If you would like to help, visit www.anaheim.net/article.asp?id-qwre to sign up and assist.
Anaheim Sister Cities Association is calling for volunteers to host 15 Japanese students this summer. This exchange program allows students from Mito, Japan to learn about life in the United States by providing a real-lie environment, unlike the American lifestyle depicted in the media. Students will visit Anaheim for two weeks beginning on July 27. During their stay, they attend classes and events. Call Charlotte Brady if you can help at 714-283-2223.
St Boniface Parish is hosting "Fiesta With Friends" from April 20 through 22 on the parish grounds at 120 N. Janss Street in Anaheim. Proceeds from the event support religious education and parish ministries. In addition, this community of St. Boniface is active in combating the drug and gang crisis in the area and working to feed the hungry. Every year St. Boniface gives aid to over 31,000 individuals and distributes over 300,000 pounds of food to needy families and homeless in Anaheim.
To become a sponsor or find out more about the event call St. Boniface at 714-956-3110 or visit the Web site at www.rc.net/orange/stboniface.
The Assistance League Anaheim is planning "A Day at The Derby" from 10:30 a.m. to 2 p.m. on Friday, April 20 at the Grand Ballroom, Disneyland Hotel. There will be a Silent and Live auction, opportunity prizes and a fashion show with guest models Matt Bennett, Dr. Steven Buchholz, Les Fujimoto, Dr. Jerome Hunter, James Klein, Paul Mercier and John Stratman, Jr. In the spirit of the Derby activities, all attendees are encouraged to wear fashionable hats. The 2007 Honoree at the event will be the Change A Life Foundation. All proceeds will benefit the Assistance League of Anaheim and assist with the philanthropic projects of the organization. For more information visit the Web site at www.assistanceleague.org.
Canyon Acres is presenting its Annual Blue Ribbon Gala on Saturday, April 21 at 6 p.m. at the Balboa Bay Club & Resort. The event includes cocktails, silent auction, dinner, program, awards, live auction and dancing to the Frank Wright Band. Honorees of the Jim Murray Memorial Service Awards are The Kent H. Landsberg Co., Padrini d'Antonello, and Glenn and Mindy Stearns. For more information contact Canyon Acres Children and Family Services at 714-385-5272 or the website at www.conyonacres.org.
A Summer Youth Job Fair is scheduled for 9:30 a.m. to 1:30 p.m. on Saturday, April 28 at two different Orange County locations. The fair is being presented in partnership with the Anaheim Workforce Center, the Orange County Youth Center, the North Orange County Community College District Anaheim Campus, and the Employer Advisory Council of Orange County. For more information contact a representative at 714-518-2323.
The Anaheim Therapeutic Recreation Booster Club will be presenting "Safari" Casino Night 2007 from 6:30 to 10:30 p.m. on Saturday, April 28 at the Brookhurst Community Center in Anaheim. All proceeds from the event will benefit the Anaheim Therapeutic Recreation program for individuals with developmental disabilities (Special Olympics, Musical Theatre, Campouts, Saturday Recreation and other programs). For more information contact the Anaheim Therapeutic Recreation Center at 714-821-6510.
The 7th Annual Alden Esping Putting Classic is scheduled for 9 a.m. on Saturday, May 19 at Golfers Paradise, 1660 N. Harbor Blvd., Fullerton. Following the golf, Passport of Memories and Casino Royale honoring Maren Greytak will finish the day for the golfers at 6:30 p.m. at Mama Cozza's, 2170 W. Ball Rd. in Anaheim. The Anaheim Family YMCA is hosting the event with proceeds to benefit youth in the Anaheim Family YMCA Camping Program at Camp Fox and Camp Miehana. Sponsorships are available and golfing is $75. Passport of Memories/Casino Royale is $40 per person (or FREE with glf registration). For more information contact the Anaheim Family YMCA at 714-635-9622.
The 11th Annual West Anaheim Bar-B-Que Festival is scheduled for Saturday, May 12 at Twila Reid Park in West Anaheim. Part of this event is the very popular "Anaheim Stars" contest that is a search for outstanding young singers. Interested junior high and high school singers must submit a completed application (available in Anaheim schools through the Student Affairs Offices or from Chairperson Barbara Matillo at 714-828-6446 or barbstst18@sbcglobal.net) before April 30, 2007. Cash prizes will be awarded to the top three winners of each of the two categories – junior high and senior high. For additional information about this competition, contact Barbara or event coordinator Anna Treachler at 714-330-3778 and atreachler@yahoo.com or the WAND 24 hour hotline 714-490-3829.


A well presented two bedroom terraced property in a popular location. Benefitting from double glazing and gas central heating the accommodation briefly comprises: entrance hall, living room, kitchen, two bedrooms, modern bathroom and low maintenance gardens. The property further benefits from parking. EPC - C.
Entrance Hall - Part-glazed UPVC front door. Radiator. Door to living room and stairs rising to first floor.
Kitchen - 2.38m x 3.59m (7'10" x 11'9") - UPVC double glazed window to rear aspect. Kitchen fitted with a range of wall and base units with laminate roll top work surface and tiled splash back. Space for washing machine, space for tumble dryer and space for fridge freezer. Built-in single oven and 4 point gas hob. Extractor hood. Stainless steel sink and drainer. Radiator and ceiling light point. Part-glazed UPVC door to rear garden.
First Floor Landing - Loft hatch and ceiling light point.
Bedroom 1 - 2.68m x 3.56m (8'10" x 11'8") - UPVC double glazed window to front aspect. Storage cupboard housing gas boiler. Built-in wardrobes with sliding doors. Ceiling light point and radiator.
Bedroom 2 - 3.29m x 2.07m (10'10" x 6'9") - UPVC double glazed window to rear aspect. Built-in wardrobes with sliding doors. Ceiling light point.
Bathroom - Obscure UPVC double glazed window to rear aspect. Modern white suite comprising: panelled bath with shower over, low level WC with hidden cistern and vanity sink. Towel radiator. Tiled walls and floors. Spot lights and extractor light.
Outside - Front - Gravelled front with paved steps giving access to the front door.
Outside - Rear - Paved patio and gravelled seating area. Steps up to wooden gate giving access to parking at the rear. Wooden shed and fence boundaries.
Directions - From our office turn right along the Worcester Road taking the first turning left into Church St. Continue down the hill and proceed through the traffic lights taking the fourth turning left into Madresfield Rd. Follow to the 'T' junction and turn left onto Pickersleigh Road, continue left into Harbinger Avenue and left into Sunrise where the property can be found on the left hand side.
Disclaimer - Property reference 28263682. The information displayed about this property comprises a property advertisement. Rightmove.co.uk makes no warranty as to the accuracy or completeness of the advertisement or any linked or associated information, and Rightmove has no control over the content. This property advertisement does not constitute property particulars. The information is provided and maintained by Philip Laney & Jolly , Great Malvern. Please contact the selling agent or developer directly to obtain any information which may be available under the terms of The Energy Performance of Buildings (Certificates and Inspections) (England and Wales) Regulations 2007 or the Home Report if in relation to a residential property in Scotland.


text:
The Ig Nobel Prizes in Mathematics
We don't have a Nobel Prize in Mathematics, and a number of hypotheses have been put forward to rationalize why Mr. Alfred Nobel didn't see fit to award such a coveted prize to the mathematical fraternity.
The closest (or an equivalent) to a Nobel Prize in Mathematics is the Fields Medal, officially known as the International Medal for Outstanding Discoveries in Mathematics, which is granted every four years to between two and four mathematicians for outstanding or groundbreaking research.
Traditionally given to mathematicians under the age of 40, Fields medalists receive an honorable Can$15,000, an amount probably sufficient enough to defray the cost of their airfare and accommodation should they decide not to channel their winnings to some charitable organization.
Ig(noble) Nobel Prize in Mathematics
For the majority of mathematicians who can't be nominated for a Fields medal, because they're not born with the "mathematical gene," there's still an infinitesimal hope that some may be awarded an Ig Nobel in Mathematics.
The Ig Nobel Prizes are an American parody of the Nobel Prizes and are given each year in early October for ten unusual achievements in scientific research. The prizes are to "honor achievements that first make people laugh, and then make them think."
These highly-coveted prizes are awarded in many categories, including the Nobel Prize categories of physics, chemistry, physiology/medicine, literature, and peace, but also other categories such as public health, engineering, biology, and interdisciplinary research.
Organized by the scientific humor magazine Annals of Improbable Research (AIR), these awards are presented by a group that includes Nobel Laureates at a ceremony at Harvard University's Sanders Theater, and they are followed by a set of public lectures by the winners at MIT.
Ig Nobel Laureates
Let's look at some past Ig Nobel winners in Mathematics, Probability, or Statistics.
The Ups and Downs of Cows
2013 Probability Prize
Bert Tolkamp, Marie Haskell, Fritha Langford, David Roberts, and Colin Morgan, from the UK, for making two related discoveries:
1. The longer a cow has been lying down, the more likely that cow will soon stand up.
2. Once a cow stands up, you can't easily predict how soon that cow will lie down again.
2011 Mathematics Prize
Dorothy Martin of the USA (who predicted the world would end in 1954), Pat Robertson of the USA (who predicted the world would end in 1982), Elizabeth Clare Prophet of the USA (who predicted the world would end in 1990), Lee Jang Rim of Korea (who predicted the world would end in 1992), Credonia Mwerinde of Uganda (who predicted the world would end in 1999), and Harold Camping of the USA (who predicted the world would end on September 6, 1994 and later predicted that the world will end on October 21, 2011), for teaching the world to be careful when making mathematical assumptions and calculations.
The Hundred Trillion Dollar Book
Gideon Gono, the governor of Zimbabwe's Reserve Bank until 2013, for giving people a simple, everyday way to cope with a wide range of numbers—from the very small to the very big—by having his bank print bank notes with denominations ranging from one cent ($.01) to one hundred trillion dollars ($100,000,000,000,000).
The Number of Shots
Nic Svenson and Piers Barnes of the Australian Commonwealth Scientific and Research Organization, for calculating the number of photographs you must take to (almost) ensure that nobody in a group photo will have their eyes closed.
Elephantine Surface Area
K.P. Streekumar and the late G. Nirmalan of Kerala Agricultural University, India, for their analytical report, "Estimation of the Total Surface Area in Indian Elephants."
No winners from 1999 to 2001.
Private Dimensions
1998 Statistics Prize
Jerald Bain of Mt. Sinai Hospital in Toronto, and Kerry Siminoski of the University of Alberta, for their carefully measured report, "The Relationship Among Height, Penile Length, and Foot Size."
Who Are Going to Hell?
The Southern Baptist Church of Alabama, mathematical measurers of morality, for their county-by-county estimate of how many Alabama citizens will go to Hell if they don't repent.
Mikhail Gorbachev, the Antichrist
Robert Faid of Greenville, South Carolina, far-sighted and faithful seer of statistics, for calculating the exact odds (710,609,175,188,282,000 to 1) that Mikhail Gorbachev is the Antichrist.
Note: In 1990 Mikhail Gorbachev was awarded the Nobel Peace Prize.
No winners in 1991 and 1992.
If you think that academic papers are darn boring, The Best of Annals of Improbable Research would dismiss that!
Research Topics for an Ig Nobel Prize Award
Let me end with some improbable or irreproducible research topics you may consider brainstorming with your team members. Who knows? You may end up getting nominated for an Ig Nobel Prize in Mathematics, Probability, or Statistics; and with some luck, even be a future Ig Nobel Laureate.
Why Singapore Math Is Russian in Origin
The Golden Ratio and Orgasm
How to Pray to a Black Hole
Deifying Primes and Matrices
Schizophrenia and Sudoku
Gambling May Prolong Your Life
The Secret Life of Pi
Vampire Literature: A Catalyst to Topological Insights
The Sound of e
Origami Pride
Pirate Math
A Calculus of Corruption
101 Uses of the Golden Mean
The Freudian Meaning of Sexy Primes
A Fourier Analysis of the Singapore Math Syndrome
^O? ^0? ^o?
Another first for Singapore!
A little-known factoid is that former Prime Minister of Singapore, Mr. Lee Kuan Yew, won the 1994 Ig Nobel Prize in Psychology, for his thirty-year study of the effects of punishing three million citizens of Singapore whenever they spat, chewed gum, or fed pigeons.
Know of any improbable research, email it to marca@improbable.com
E-mail your Ig Nobel Nominations to air@improbable.com
Visit the Annals of Improbable Research Web site.
Abrahams, M. (2012). This is improbable: Chesse string theory, magnetic chickens, and other WTF research. Oxford: Oneworld Publications.
Abrahams, M. (2002). The Ig Nobel Prizes: The Annals of Improbable Research. New York: Dutton.
Abrahams, M. (ed.) (1998). The Best of Annals of Improbable Research. New York: W. H. Freeman and Company.
Scherr, G. H. & Glenn, J. (eds.) (1997). The Journal of Irreproducible Results II. New York: Barnes & Noble Books.
You'll have a heck of a good time reading the papers gracing the pages of the Journal of Irreproducible Results!
Labels: Alfred Nobel, Annals of Improbable Research, Fields medal, Humor, Ig Nobel Prize in Mathematics, Lee Kuan Yew, math humor, Nobel Prize, parody, probability, research, Singapore Math, Statistics


Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC.
A 61-year-old man presented with an increased anion-gap metabolic acidosis, an increased serum osmolal gap, and a negative result in an alcohol screen. Gas chromatography revealed an increased ethylene glycol (EG)2 concentration (22 mg/dL) and a propylene glycol (PG) result that was below the lower limit of quantification (<5 mg/dL) (Fig. 1A). The patient was treated with hemodialysis, followed by phenytoin and a high-dose lorazepam infusion for a witnessed seizure. By 13 h, the EG concentration had fallen below the lower limit of quantification (<5 mg/dL); however, a peak identified as PG was observed, corresponding to a concentration of 27 mg/dL (Fig. 1B).
Fig. 1. Chromatograms of EG, PG, and 1,3-propanediol (internal standard).
(A), EG peak (22 mg/dL). (B), PG peak (27 mg/dL). +P, enablement of peak detection; −P, disablement of peak detection; 1,3-PRO, 1,3-propanediol.
What are the common causes of EG or PG poisoning?
What could cause a positive EG result and then a positive PG result in this patient?
What is the difference in toxicity between EG and PG?
The answers are on the next page.
Ingesting automotive fluids, such as antifreeze containing EG or PG, can cause poisoning (1, 2). PG is also a solvent in many pharmaceuticals. Intravenous infusion of large amount of medications that use PG as a vehicle can cause PG poisoning (3–5). In our case, consumption of antifreeze led to the initial positive EG result, and the phenytoin treatment and a subsequent high-dose lorazepam infusion, both which contained PG, led to the positive PG result. This substance is less toxic than EG; however, poisoning cases associated with overdose of medications with PG as diluent have been described (3–5).
Received for publication June 4, 2013.
Accepted for publication June 24, 2013.
. 2010 Annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 28th annual report. Clin Toxicol (Phila) 2011;49:910–41.
. 1996 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med 1997;15:447–500.
. Propylene glycol toxicity: a severe iatrogenic illness in ICU patients receiving IV benzodiazepines: a case series and prospective, observational pilot study. Chest 2005;128:1674–81.
. Short-term lorazepam infusion and concern for propylene glycol toxicity: case report and review. Pharmacotherapy 2001;21:1140–4.
. Propylene glycol-associated renal toxicity from lorazepam infusion. Pharmacotherapy 2003;23:1094–9.


text:
Antimicrobial Resistance – the Rise of Global Superbugs
Article Sep 04, 2018 | By Natasha Beeton-Kempen, Ph.D.
Credit: iStock.
Until the early 19th century one in two people used to die from infectious diseases before the age of 20 years.1 The global life expectancy has now increased to 72 years and the discovery of antimicrobials was one of the major drivers of this improvement in human health.
Antimicrobials kill or inhibit the growth of bacteria (these are also called "antibiotics"), parasites, viruses, and fungi.1 In 1928, Alexander Fleming famously isolated the first antibiotic from the mold Penicillium notatum. Beginning in 1942 during World War II, the mass production of penicillin officially ushered in the era of antibiotics.
Antibiotics have since revolutionized medicine by enabling treatments that would once have proven fatal, e.g., critical care medicine (such as the use of ventilators and catheters), cancer treatments, orthopedic surgery, organ transplantation, the care of premature babies, and the treatment of autoimmune diseases. 2–4 Indeed, most surgical procedures rely on antibiotics to prevent life-threatening postoperative infections. Antimicrobials are now not only extensively used in human healthcare, but also in toiletries, cleaning products for household and industrial use, and agriculture.
However, antimicrobials have since proven to be a double-edged sword.
What is antimicrobial resistance?
Antimicrobial resistance (AMR) refers to the inheritable genetic changes that microbes accumulate to reduce or eliminate the efficacy of antimicrobials.2,3,5
Over the past 60 years, millions of metric tons of antimicrobials have been distributed worldwide in various products.2 This extensive exposure has led to the emergence of multidrug-resistant (MDR), extensively drug-resistant (XDR), and pandrug-resistant (PDR) organisms such as the Klebsiella and Acinetobacter species.6 Resistant pathogenic strains can develop within only a year of antimicrobial exposure,7 and the death rate from infections with these strains can approach 50%.6
Despite antibiotics only being in extensive use for several decades, certain bacterial infections are now on the verge of becoming untreatable.5
Some common resistant microbes
In 2017, the World Health Organization (WHO) released a list of AMR pathogens posing the greatest threat.8 The medium and high threat categories include Staphylococcus aureus (S. aureus); cause of pneumonia, as well as bloodstream, skin and soft tissue infections), Vibrio cholerae, Streptococcus pneumoniae (cause of pneumonia and bacterial meningitis among others), and bacteria that cause common diseases such as food poisoning (Salmonella) and gonorrhea (Neisseria gonorrhoeae). The critical category includes bacteria that cause severe (and sometimes deadly) bloodstream, urinary, and respiratory tract infections in hospitals and nursing homes. These include Acinetobacter, Pseudomonas aeruginosa, Serratia, Proteus, Klebsiella, and Escherichia coli.
Because there are already extensive efforts underway to combat tuberculosis, Mycobacterium tuberculosis is not on this priority list. However, several MDR and XDR strains of tuberculosis have emerged.9
How do microbes acquire resistance?
AMR arises spontaneously through random genetic mutations, and the prevalence of these mutations increases in response to selection pressure from competing microbes, invading pathogens, and human antimicrobial use.2,10 Other microbes then inherit these genes by descent. Only one bacterium in a population needs to be resistant to an antibiotic for drug resistance to emerge.
Particularly worrying, is that certain microbes can also receive AMR genes from non-relatives, even from other species.1,5 AMR is especially a concern for the Gram-negative bacteria on the WHO priority list, as over and above their inherent, physical barriers to antibiotic treatment, these species readily transfer resistant genetic material to other bacteria.
Why are "superbugs" a global threat?
The term "superbugs" describes microbes with enhanced morbidity and mortality due to high levels of antibiotic resistance.7 These microbes have fewer treatment options and are associated with extended and costlier periods of hospital care. In some cases, these superbugs have also acquired increased virulence and enhanced transmissibility.
One of the most notorious superbugs is S. aureus.3 This multidrug-resistant pathogen has been a major source of hospital-acquired infections; recently, however, MDR strains have also moved into the community. Another superbug is Salmonella enterica, with some strains resistant to five antibiotics.7 Most concerning, however, is the emergence of pathogens resistant to nearly all (and in rare cases, all) antimicrobials, such as carbapenem-resistant Klebsiella pneumoniae.11,12
Approximately 700,000 deaths per year are attributed to AMR, but with the emergence of more and more "superbugs", this number is projected to rise to 10 million by 2050 at a cost of $100 trillion.13 The rise of AMR is therefore considered by experts to be one of the most critical issues in modern healthcare.
How do we best prevent the rise of "superbugs"?
Experts suggest two major approaches to slow the spread of AMR: (1) reduce the number of infections, and (2) reduce antibiotic use.2
Whenever an infection is prevented, one less person needs to be prescribed drugs. According to Prof. Willem van Schaik of the Institute of Microbiology and Infection at the University of Birmingham, one of the leading EU institutes researching AMR, "The most important technology for combatting drug resistance is to prevent infections. This can be done by technologically simple solutions (e.g., handwashing by healthcare workers, and isolation of patients colonized by multidrug-resistant bacteria), but novel approaches (e.g., disinfection of air by UV) are promising too. As prevention is always better than treating infections, vaccine-based approaches to combat AMR are of considerable interest as well."
Indeed, many experts agree that improved vaccine design, production, and delivery methods may eventually comprise the main strategy for combating AMR.1 Other than vaccines, isolation, and proper hygiene, surveillance is also key. Next-generation sequencing technologies, which can sequence the entire genomes of microbes, are increasingly being used to track AMR genes across the food chain.14,15 However, such surveillance has not yet been implemented worldwide, and most countries still rely on older, less informative techniques to characterize specimens. In fact, many parts of the world currently lack adequate (if any) surveillance methods.9 AMR surveillance, therefore, requires global strengthening and harmonization, with the adoption of agreed methods and standards.
Every administered dose of antibiotic drugs selects for resistance.2 Antibiotic stewardship is critical to ensure that antibiotics are taken in the right amounts for the full course and only when necessary.
Antibiotics were, until recently, freely available in most parts of the world. However, even when not provided over the counter, misuse is rampant. In the US alone, healthcare providers prescribed 258 million courses of antibiotics (833 prescriptions per 1000 persons) in 2010.9 At least 50% of all these antibiotic prescriptions are deemed unnecessary.
More information campaigns (such as Get Smart) targeted at both the consumer and healthcare professional are needed.9 Many people take antibiotics to treat the common cold and flu, even though antibiotics are ineffective against both. Prescription audits should, therefore, become routine. Improved diagnostics that allow rapid, point-of-care identification of the pathogen down to strain level would also help healthcare providers improve their antibiotic treatment decisions.
Interventions are also required to prevent the ongoing misuse of antimicrobials in cleaning products, agriculture, and other industries.9 In certain countries, up to 75% of all antibiotics are used for veterinary applications.2,16 Antibiotics are used in livestock and poultry to treat diseases and in sub-therapeutic doses as growth promotants or prophylactics to compensate for stressful and unsanitary conditions. In the US, around 8 billion animals are treated by as many as 10 different antibiotics. Worryingly, many of the same antimicrobial classes are also used in human health.
A further concern is that an estimated 75% of all antibiotics given to animals are not fully digested.16 Vast quantities of manure are routinely sprayed onto fields and these antibiotics leech into the water supply. The AMR bacteria that arise can be spread by animals, birds, and insects.17–19 Large amounts of antibiotics are also released into municipal wastewater because of incomplete metabolism in humans and the disposal of unused antibiotics.9 Plant products can also be affected through irrigation with contaminated water.10 Regulations governing the non-human use of antimicrobials, therefore, need to be put in place and/or more strictly enforced, and consumers should rally for improved animal husbandry to reduce the need for antimicrobials.
Why don't we just discover more new antibiotics?
Despite the issue of AMR, the search for new antimicrobials remains a priority for treating severe infections. However, new antibiotic development has slowed to a standstill because of financial and regulatory disincentives.4,11 FDA approvals declined by 94% between the mid-1980s and 2010, with only two approvals between 2008 and 2013. With over 140 antibiotics developed over the past century, the "easy" discoveries have already been made.
Antibiotics are also not as profitable as drugs used for long-term conditions, and this is particularly true where proper antibiotic stewardship is in place. Indeed, the cost of developing a new antibiotic is now likely to outstrip the return.11 As Prof. Willem van Schaik says, "The economy of antibiotic R&D in large pharmaceutical companies is challenging as new antibiotics are unlikely to become important profit generators in the short-term and so are unlikely to be prioritized by large, shareholder-driven companies."
Some economic and regulatory incentives have, therefore, been provided by the FDA (through the GAIN Act) and through public-private funding bodies such as the CARB-X collaboration between the US and UK, and the "New Drugs for Bad Bugs" program in the EU.4,20 An alternative public-private partnership, the Global Antibiotic Research and Development Partnership (GARDP), sources funds to not only develop antibiotics but also to ensure their sustainable access. However, more resources are likely needed.
Another avenue is the repurposing of "old" antibiotics. As Prof. Laura Piddock, Head of Scientific Affairs at GARDP says, "In addition to identifying new drug candidates, we are recovering the knowledge, data, and assets of forgotten or undeveloped antibiotics that can be candidates for pre-clinical or clinical development."
It is, of course, crucial that any new antibiotics be scrupulously guarded against misuse to prevent the rapid rise of AMR yet again.
Are there any alternatives to antibiotics?
There are several emerging technologies that may provide alternatives to antibiotics. Other technologies include CRISPR, antimicrobial peptides, and phage therapy, although these all face significant challenges to clinical implementation.6, 7,16 Pathogens could potentially be targeted for neutralization rather than destruction, thus exerting less selection pressure to drive resistance.4 Alternatively, the host, rather than the microbe, could be targeted to modulate the immune response and the host environment to minimize the effects of infection without resorting to antibiotics.
For a while, the discovery of antibiotics mostly eliminated the threat of infectious diseases. But now, some scientists believe we are approaching a post-antibiotic age.1,2 We face a future in which people again die of common infections and medical interventions begin to pose unacceptable risks.
In the words of Alexander Fleming: "…the thoughtless person playing with penicillin is morally responsible for the death of the man who finally succumbs to infection with the penicillin-resistant organism."4
We must actively encourage the return of susceptible microbes into the clinical and overall environment.
1)	Tagliabue A., Rappuoli R. Changing priorities in vaccinology: Antibiotic resistance moving to the top. Frontiers in Immunology. 2018, 9, article 1068. doi: 10.3389/fimmu.2018.01068.
2)	Smith R.A., M'ikanatha N.M., Read A.F. Antibiotic Resistance: A Primer and Call to Action. Health Communication. 2015;30(3):309–314. doi:10.1080/10410236.2014.943634.
3)	Davies J., Davies D. Origins and Evolution of Antibiotic Resistance. Microbiology and Molecular Biology Reviews 2010;74(3):417–433. doi:10.1128/MMBR.00016-10.
4)	Spellberg B. The future of antibiotics. Critical Care. 2014;18(3):228. doi:10.1186/cc13948.
5)	Perry J., Waglechner N., Wright G. The Prehistory of Antibiotic Resistance. Cold Spring Harbor Perspectives in Medicine. 2016;6(6):a025197. doi:10.1101/cshperspect.a025197.
6)	Steckbeck J.D., Deslouches B., Montelaro R.C. Antimicrobial peptides: new drugs for bad bugs? Expert Opinion on Biological Therapy. 2014;14(1):11–14. doi:10.1517/14712598.2013.844227.
7)	Ali J., Rafiq, Q.A., Ratcliffe E. Antimicrobial resistance mechanisms and potential synthetic treatments. Future Science OA. 2018;4(4):FSO290. doi: 10.4155/fsoa-2017-0109.
8)	WHO publishes list of bacteria for which new antibiotics are urgently needed. World Health Organization. 27 February 2017. (http://www.who.int/news-room/detail/27-02-2017-who-publishes-list-of-bacteria-for-which-new-antibiotics-are-urgently-needed)
9)	Prestinaci F., Pezzotti P., Pantosti A. Antimicrobial resistance: a global multifaceted phenomenon. Pathogens and Global Health. 2015;109(7):309–318. doi:10.1179/2047773215Y.0000000030.
10)	Meredith H.R., Srimani J.K., Lee A.J., Lopatkin A.J., You L. Collective antibiotic tolerance: Mechanisms, dynamics, and intervention. Nature Chemical Biology. 2015;11(3):182–188. doi:10.1038/nchembio.1754.
11)	Toner E., Adalja A., Gronvall G.K., Cicero A., Inglesby T.V. Antimicrobial resistance is a global health emergency. Health Security. 2015;13(3):153–155. doi:10.1089/hs.2014.0088.
12)	Doorduijn D.J., Rooijakkers, S.H., van Schaik W., Bardoel B.W. Complement resistance mechanisms of Klebsiella pneumoniae. Immunobiology. 2016;221(10):1102–1109. doi: 10.1016/j.imbio.2016.06.014.
13)	O'Neill J. Antimicrobial resistance: tackling a crisis for the health and wealth of nations. 2014. (http://amr-review.org/sites/default/files/AMR%20Review%20Paper%20-%20Tackling%20a%20crisis%20for%20the%20health%20and%20wealth%20of%20nations_1.pdf)
14)	Oniciuc E.A., Likotrafiti E., Alvarez-Molina A., Prieto M., Santos J.A., Alvarez-Ordóñez, A. The present and future of whole genome sequencing (WGS) and whole metagenome sequencing (WMS) for surveillance of antimicrobial resistant microorganisms and antimicrobial resistance genes across the food chain. Genes. 2018;9(5):268. doi:10.3390/genes9050268.
15)	Köser C.U., Ellington M.J., Peacock S.J. Whole-genome sequencing to control antimicrobial resistance. Trends in Genetics. 2014;30(9):401–407. doi:10.1016/j.tig.2014.07.003.
16)	Jassim S.A.A., Limoges R.G. Natural solution to antibiotic resistance: bacteriophages "The Living Drugs." World Journal of Microbiology & Biotechnology. 2014;30(8):2153–2170. doi:10.1007/s11274-014-1655-7.
17)	Zurek L., Ghosh A. Insects represent a link between food animal farms and the urban environment for antibiotic resistance traits. Müller V, ed. Applied and Environmental Microbiology. 2014;80(12):3562–3567. doi:10.1128/AEM.00600-14.
18)	Vaz-Moreira I., Nunes O.C., Manaia C.M. Bacterial diversity and antibiotic resistance in water habitats: searching the links with the human microbiome. FEMS Microbiology Reviews. 2014;38(4):761–78. doi: 10.1111/1574-6976.12062.
19)	Verraes C., Van Boxstael S., Van Meervenne E., et al. Antimicrobial Resistance in the Food Chain: A Review. International Journal of Environmental Research and Public Health. 2013;10(7):2643–2669. doi:10.3390/ijerph10072643.
20)	Carlet, J., Pulcini C., Piddock, L.J.V. Antibiotic resistance: a geopolitical issue. Clinical Microbiology and Infection. 2014;20(10):949–953. doi.org/10.1111/1469-0691.12767.
Proteomics, "Zombie" Cells and Clinical Biomarkers of Aging
In a new study scientists have harnessed advances in proteomics to extensively profile the secretions of senescent cells which are implicated in aging. Their analyses are collated in a database that is now available for researchers in the field.
Exploring the Medicinal Benefits of Cannabis Within UK Pharmaceuticals
In this article, we explore how the use of cannabis within UK pharmaceuticals is expected to change, as well as the medicinal benefits offered by cannabis, and cannabinoids.
The Importance of Understanding Target–Protein Interactions in Drug Discovery
You're unwell, you see a doctor, they prescribe you a medicine… and you take it. But how exactly is that drug having an effect? What is its mechanism of action? Drugs exhibit their effects through specific protein–target interactions. Andrew Lynn, Chief Executive Officer at Fluidic Analytics discusses why understanding protein–target interactions is so important.
Like what you just read? You can find similar content on the communities below.
Analysis & Separations Biopharma Drug Discovery Proteomics & Metabolomics
Sourcing Fresh Human Blood Products for Research
Ligand-Receptor Binding Kinetics on the PHERAstar® Microplate Reader
Exploring Methods for Host Cell Protein Analysis
PAA to Showcase New Laboratory Automation Solutions at SLAS2020
Breakthrough in Battle To Curb Dengue
Harmful Algal Bloom Toxins Detected in Urine Test
EZ-PCR Mycoplasma Detection Kit
Microsart® Sterility Kits
Beware of Online Probiotic Health Benefit Claims


http://vimeo.com/28536613 Well, my vane display post got some Adafruit love and many of my other posts on old display technology have gotten some traffic so here is one more.
I love finding antique display technology on eBay and a few days ago I came across a dozen old edge lit displays, also known as lightguide displays. Basically, a piece of plastic is bent to allow light to enter at the rear of the device. This plastic guides the light to the front where small holes are dilled to form numbers of symbols. Each digit or symbol has a corresponding lightguide and incandescent bulb. If one were so inclined, you could also swap these bulbs out with a nice LED and come up with a display that offered more colors and was easier to drive using contemporary circuitry.


New exercise pictures, thanks Pro-Fit!
Fitness on a Budget with Support Workouts.
Body Blast Bootcamp. Shed some unwanted pounds with HIIT workouts.
This site contains all info about Freetrainerscom Free Workout Plans Custom exercise.
This site contains all about Create Free Exercise Workout Plans FreeTrainerscom.
Diary of a Fit Mommy23 Free Workout Plans That Will Totally .


Cellulitis is a somewhat for all type of pores and skin infection. That infection is frequently attributable to either a Staphylococcus or even Streptococcus bacteria. The germs type in the skin color in limits, injuries, discoloration, operative openings otherwise various other initiates of which break up the strength from the skin hurdle.
As cellulitis is located limited on the skin, it truly is rarely dangerous. The infection determination foundation native skin tone discomfort, bother, ruddiness with raising except will probably sojourn with these. Cellulitis isn't basically a life-threatening prepare. However, deadly cellulitis canister take place if your infection gets into the bloodstream.
Just how do cellulitis extend?
Cellulitis tin daub when the infection goes through deeper skin tone constitutes. Normally, the primary constitute impacted may be the ligament, a shiny membrane disguise as a consequence guarding the muscles grains. Any time cellulitis stretch to the deeper fascial levels, it could cause necrosis or perhaps "demise" on the muscle mass tissue. Cellulitis may also unfold throughout the bloodstream. Whilst community skin tone scratches chance deeper, the microorganisms making happen the cellulitis might go in with the blood vessels as well as multiply in attendance. This may result in poisoning in the body in a way. Since the body travels throughout the entire body, the infection can extend headed for additional better part component and appendages likewise. Apart from stretching by the use of the bloodstream, cellulitis place can also really do the reaction to the infection concerning close at hand or else nearby bodies. One example is, cellulitis within the outer eyelid could widen towards close organ that is the look at. Since the attention is really a critical wood, the person will probably be terribly hadn't an effect on due to the allot regarding infection. Whilst cellulitis enjoys extend, this is converted into strenuous to treat.
How might you stash cellulitis on or after getting in touch with a life-threatening mess?
The easiest method to keep away from inducing cellulitis remains to be reduction because of characteristic care next epidermis assiduousness. Elude enhance disturbance to help your own skin color plus check with a health practitioner if the drop as well as beat inside the skin color foundations symptoms of infection. Bear in mind from the motions moreover symptoms regarding infection such for instance glow, burning itch, wave, bind, temperature and also a defeat otherwise cut now organization run from the infected role. Work antibiotics as ordered because of your doctor also always preserve a proper lifestyle.


text:
Петър Алипиев е български поет и преводач.

Биография
Роден е на 14 март 1930 г. в село Босилковци и е кръстен Пашанко Пеев, но на зряла възраст го променя на Петър Алипиев. Учи в Бяла и Русе. Работи като литературен редактор в Радио София, а от 1963 г. до смъртта си живее и твори във Варна. Работи като редактор в Държавно издателство "Георги Бакалов". Автор е на множество преводи на поети като Александър Пушкин, Алексей Колцов, Николай Заболоцки, Николай Рубцов, Шандор Петьофи, Николаус Ленау. Два пъти вестник "Литературен форум" посвещава на Алипиев отделни издания с участия на видни фигури от българската култура (2008; 2018). Негова дъщеря е Антоанета Алипиева, професор по съвременна българска литература в Шуменския университет и в Белградския университет. Съпругата му Вълка Алипиева е видна фигура в българското образование през 70-те и 80-те години от 20.век. На негово име е кръстена улица в град Варна.

По-важните книги на Петър Алипиев са "Лирика" (1961), "Без малко Тиртей. Картини от една изложба" (1992), "Българска поезия. Антология" (1994). Алипиев е автор на една-единствена стихосбирка с име "Лирика", която преиздава през целия си живот. Това е вторият случай в българската поезия след Атанас Далчев, според който даден поет е автор на една-единствена стихосбирка. През 2000 г. излиза антологията "Поетичен декалог" под съставителството на Димитър Ефендулов. Стихове на Алипиев са превеждани на почти всички европейски езици.

Библиография
 Лирика. София: Изд. "Български писател", 1961.
 Лирика. Варна: ДИ "Варна", 1966.
 Лирика. София: Изд. "Български писател", 1972.
 Лирика. Пловдив: ДИ "Хр. Г. Данов", 1985.
 Лирика. Варна: ИК "Галактика", 1989.
 Дъжд през юли. София: Изд. "Български писател", 1990.
 Без малко Тиртей. Варна: ИК "Галактика", 1992.
 Лирика. Варна: ИК "Галактика" 1996.
 Стихове. Преводи. София-Будапеща, 1997 – двуезично издание на български и унгарски.
 Лирика. Варна, 2000.

 Съставителство
 Море, стихия, вечност (с Андрей Германов), Варна: Книгоиздателство "Г. Бакалов", 1972.
 Българска поезия. Антология, Варна: ИК "Галактика", 1994.

 Преводи
 Йосиф Уткин, Избрани стохотворения, София: ДИ "Народна култура", 1963.
 А.В. Колцов, Избрани стихотворения, София: ДИ "Народна култура", 1977.
 Аведик Исаакян, Избрани стихотворения и поеми, София: ДИ "Народна култура", 1980.
 Андрей Рубцов, Избрани стихотворения, София: ДИ "Народна култура", 1980.
 Андрей Дементиев, Хазарт, София: ДИ "Народна култура", 1984.
 Шандор Петьофи, Любов и свобода. Избрана лирика, Варна: Книгоиздателство "Г. Бакалов", 1988.
 Николаус Ленау, Пощенският рог. Избрана лирика, Варна: Книгоиздателство "Г. Бакалов", 1989.

Външни препратки
 От и за Петър Алипиев в Своден каталог НАБИС – национален каталог на академичните библиотеки в България

 Стихове на Петър Алипиев от "Поетичен декалог", Литернет
 Критика за Петър Алипиев в Литернет
 Вихрен Чернокожев, "Петър Алипиев – Следюбилейно", Литернет
 Надежда Александрова, "Балконът на Петър Алипиев", електронно списание Библиосфера, 2006 №8
 Никола Иванов, Лирикът Петър Алипиев, Литературен свят, бр. 16, януари 2010
 Велкова-Гайдаржиева, А. Сезоните на Петър Алипиев - в: Литературен вестник, 2015, https://litvestnik.com/2015/04/16/%D1%81%D0%B5%D0%B7%D0%BE%D0%BD%D0%B8%D1%82%D0%B5-%D0%BD%D0%B0-%D0%BF%D0%B5%D1%82%D1%8A%D1%80-%D0%B0%D0%BB%D0%B8%D0%BF%D0%B8%D0%B5%D0%B2/

Български поети
Български преводачи
Български преводачи на рускоезична литература
Родени в област Русе
Починали във Варна


text:
"""
Tornado app for serving live file system events of watched directories,
using WebSocket
"""
from tornado import ioloop
from tornado import web

from argus import settings
from handler import ArgusWebSocketHandler

def make_app():
    """
    Creates tornado application which routes incoming requests to handlers
    """
    return web.Application(
        [
            (r'/ws/watch/(?P<path>.+)/?', ArgusWebSocketHandler),
        ]
    )

def runserver():
    """
    Starts server at ARGUS_ADDRESS:ARGUS_PORT given by the settings.
    """
    print 'Starting Tornado IO loop at {}:{}'.format(
        settings.ARGUS_ADDRESS, settings.ARGUS_PORT
    )
    app = make_app()
    app.listen(settings.ARGUS_PORT, settings.ARGUS_ADDRESS)
    try:
        ioloop.IOLoop.current().start()
    except KeyboardInterrupt:
        print '\rClosing... (Interrupted by keyboard)'

if __name__ == '__main__':
    runserver()

redpajama_set_name: RedPajamaGithub


text:
DISRUPTOR CONNECTION
UNDIVIDED CONFERENCE
DL+
DISRUPTOR STUDIO
DISRUPTOR DIGEST
Rockstar Studios Knows How to Innovate
May 27, 2011 / Jorge Barba / No Comments
Yesterday I wrote about how innovation requires courage. It takes guts and vision to do something that is so remarkable, that it changes everything. Here then, is a great example.
Innovation in the gaming industry is hard to come by. Games haven't changed much in the last decade. The only noticeable different take on games was introduced by one of my favorite gaming studios, Rockstar Games, the creators of the Grand Theft Auto series and the recent Red Dead Redemption. They introduced games with free roaming worlds and great story telling, approaches that have been adopted by various game studios and applied to other genres with great success.
And now, with the recently released L.A. Noire, they've topped themselves once more. Video game developers have been making realistic cars and buildings for years, but L.A. Noire is set to take facial realism to the next level.
Games will never be the same
To take advantage of the absorbing investigation mechanics they wanted to introduce into the gameplay of L.A. Noire, Rockstar developed a new type of facial scanning technology.
Watch the video below for further context:
But why develop new technology?
Because this motion scanning technology fully captures the facial movements in actors face (similar to the technology used in the movie Avatar). And, because you are a detective in the game, you'll be interrogating witnesses and observing their facial gestures to make better decisions. And if you don't read facial expressions correctly, it could be the end of your case.
Yes. This takes interaction to another level. Our interaction with the game is much more rich, it's a totally different experience from just clicking buttons. If we couldn't observe the facial expressions of in-game characters, this game would not be the same because it adds another dimension to the game play.
Without it, it would be just another Mafia game.
Rockstar Studios is known for having both guts and vision, constantly upping the ante on game play and overall game experience. And in a medium of 'me too's', LA Noire is refreshing and sets a new standard in storytelling.
Here's a short video review of the game so you know what I say when this is ground breaking:
They clearly had a vision of what they wanted to do. Implementing a technology 5 years in the making and then building a game that not only showcases that technology but is a key enabler to the game play, they created a game changer.
L.A. Noire is a bold and unique take on games as entertainment. No one's ever played a game like this before. Fresh, different and totally unique. A game that is truly deserving of recognition.
Kings to them!
Don't miss an article (2,700+) – Subscribe to our RSS feed and join our Innovation Excellence group!
Jorge Barba is an Innovation Insurgent and is the Creative Strategist at Blu Maya, a San Diego based Digital Marketing Firm that helps organizations build their online business with strategy development for new products and services. He's also the author of the innovation blog Game Changer. And lastly, you can follow him on Twitter @jorgebarba.
Posted in Innovation
Jorge Barba
← Importance of Empathy to Leadership
What do Innovators Know That You Don't? →
NEVER MISS ANOTHER NEWSLETTER!
Categories Select Category Africa (3) Anonymous (1) Apple (145) Asia (11) Associations (6) AXP OPEN Forum (7) Blogging Innovation (104) Book Review (133) Build Capability (741) Build Capability Video (4) Business (6) Business Models (300) Case Study (171) Celebrity (24) Change (264) Cognition (17) collaboration (600) Community (4) Compassion (1) Competitions (123) Conferences (77) Consulting (1) Consumer Innovation (205) Conviction (1) Courage (2) Covid (2) Creativity (898) culture (396) Culture & Values (534) Culture & Values Video (7) Customers (271) Data (19) Design (403) Design Thinking (2) Development (4) Digital (196) Disruption (207) Disruptor (1) education (263) Empathy (4) Engagement (2) Entertainment (94) Entrepreneurship (483) Europe (17) Excellence (3) Experience Innovation (43) Feature Of The Week (650) Finance (90) French (5) Games (16) Governance (47) Government (191) Growth (251) Headlines (269) Health/Healthcare (132) Inclusion (1) Industry (155) Infographic (16) Innovation (5,463) Innovation Perspectives (197) Innovation Teaching Story (29) Inspiration (173) Intellectual Property (39) Interview Videos (3) Interviews (133) Jobs (43) Latin America (3) Leadership (1,411) Leadership (4) Leadership & Infrastructure (369) Leadership & Infrastructure Video (6) Management (1,294) marketing (654) Military Innovation (5) Mindfulness (1) Mindset (10) News (118) North America (1) Op Ed (38) Open Innovation (354) People & Skills (788) People & Skills Video (8) Policy (24) Portuguese (1) Presentations (172) Processes & Tools (513) Processes & Tools Video (5) Product Innovation (350) Profiles of Innovators (238) Psychology (619) Publishing (36) Purpose (2) Quotes (72) R&D (79) Racism (1) Research (194) Sales (115) Science (93) Self-Compassion (1) Service (26) Simplicity (1) Social Innovation (165) Social Media (334) Spanish (8) Strategy (1,582) Survey (7) Sustainability (65) Swedish (1) Teams (1) Technology (523) Technology (46) The Economy (93) Time Management (30) Top 10 (180) Topic Of The Month (2) Training (39) Trends (34) Uncategorized (480) Video (216) Visualization (17) Webinar (9)
Apple Business Models change collaboration Creativity Crowdsourcing culture Customers Design Design Thinking digital Disruptive Innovation education Entrepreneurship failure future Google growth ideas Innovation Innovation Management Innovation Mindset innovative thinking internet ipad kindle Leadership Management marketing michael graber mobile Most Popular Nook Open Innovation Process research Social Media Southern Growth Studio startups Strategy success tablets technology Top 20 Trends
Diversifying the Corporate Boardroom
By Dan Blacharski	| January 18, 2021
Diverse talent is abundant, but do you still need to know the secret handshake? A small group of tenured leaders,…
Tales from the Road: Navigating the Complicated World of Consulting
By Shawn Nason	| January 14, 2021
MOFI's experience SWAT team is always looking for its next challenge and never shies away from even the biggest, hairiest…
© 2020 Disruptor League | Privacy Policy