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Last updated: 11:58 PM ET, Sat December 27 2014
AirAsia Plane Loses Contact With Air Traffic Control
Airlines & Airports	Tim Wood December 27, 2014
An AirAsia flight from Indonesia to Singapore has lost contact with air traffic control with 155 passengers and crew on board.
According to the airline, flight QZ 8501 left the Indonesia city of Surabaya bound for Singapore before losing contact with air traffic control at 7:24 a.m. Sunday local time (7:24 p.m. EST Saturday).
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The airplane, an Airbus A320-200, left Juanda International Airport at 5:27 a.m. Sunday local time (5:27 p.m. EST Saturday) and was scheduled to arrive in Singapore at 8:37 a.m. Sunday.
The airline released the following statement Saturday night:
"AirAsia Indonesia regrets to confirm that flight QZ8501 from Surabaya to Singapore has lost contact with air traffic control at 07:24hrs this morning.
At the present time we unfortunately have no further information regarding the status of the passengers and crew members on board, but we will keep all parties informed as more information becomes available.
The aircraft was an Airbus A320-200 with the registration number PK-AXC.
At this time, search and rescue operations are in progress and AirAsia is cooperating fully and assisting the rescue service.
AirAsia has established an Emergency Call Centre that is available for family or friends of those who may have been on board the aircraft. The number is: +622129850801.
AirAsia will release further information as soon as it becomes available. Updated information will also be posted on the AirAsia website, www.airasia.com."
The incident comes more than eight months after the disappearance of Malaysia Airlines Flight 370, whose last contact came over Southeast Asia in March.
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NICK GANJU^'08BUS^Founder at Zocdoc
Nick Ganju '08BUS is a founder at Zocdoc and leads strategic initiatives that address some of the company's most impactful opportunities. He helped build Zocdoc because he believes that the power of technology can bring about a more efficient healthcare system. He has extensive experience in product development, database management and site architecture, including having personally built the earliest iterations of Zocdoc and directly overseeing its development for many of its first years.
Prior to Zocdoc, Nick worked as the CTO of cfX, where he oversaw the design and implementation of financial software used by several Fortune 100 Wall Street firms. A Trilogy Development Alumnus, Nick previously lived in Silicon Valley. There, he played a pivotal role in the architecture and development of eBoodle (later acquired by BizRate), and in 2002 founded his first company, called Mixonic. He remained at Mixonic as the architect, manager, and lead programmer until moving to New York.
Nick was awarded an MBA from Columbia Business School in 2008. He also has a bachelor's degree in Computer Science from the University of Illinois at Urbana-Champaign. He first met Zocdoc founder Cyrus Massoumi when the two shared a desk at Trilogy Software.
Nick was born and raised in Chicago, and currently resides in New York. When he's not working, the former Bay Area Amateur Billiards Champion can be found fronting his semi-professional cover band.
See Nick in action at #StartupColumbia
2017 Columbia Venture Competition
2017 JudgeGraphic Design Intern January 11, 2018 2017
MILLEN ANAND^'20SEAS^Co-President of the Columbia Space Initiative and a member of the Columbia Organization of Rising Entrepreneurs
2018 SpeakerGraphic Design Intern January 12, 2018 Student
Marisol Rodriguez^'15SPS

redpajama_set_name: RedPajamaCommonCrawl


Imagine catching anyone on a joyride in your beloved car? You'd probably be a little pissed, right? Now imagine it's actually the auto mechanics from the shop you're paying to service your Nissan 350Z. I would go ballistic. Randy Jones, the shift manager at the Taco Bell restaurant, saw his own vehicle in the drive-thru lane where he worked.
He ended up getting a pretty sweet deal from the Nissan dealership in Riverside, while the two mechanics got fired for being 2 miles off the specific route employees use for diagnostic tests.
Nevertheless, he was so pissed that he still blew the whistle on the Raceway dealership to the news.


Entries close at 2pm AEST on Wednesday 5 October 2016 which is TOMORROW, so get in quick. Good luck! Terms and conditions can be found here.
Already entered and can't see your comment below? Never fear — it may be on one of our previous posts!
When I was an Air Force Cadet, we had the opportunity to fly in a Cessna light plane. I was lucky and got the front seat, and midway through the pilot let me have a go at the controls.
I tried to do a barrel roll, but freaked out halfway through. That few seconds of what was essentially free-fall in a tiny plane would stick to me forever.
Many years ago, when Tool first toured Australia for Lateralus, some friends & I made a road trip down to Sydney because they weren't playing Brisbane.
We of course didn't bother to book accommodation so the night we arrived we got stuck out in the rain trying to find some.
We ended up staying in this strange Backpackers place that was multiple buildings attached, so if you went wandering you could easily lose your way. The guy running the place was this Rastafarian guy that I'll never forget.
Because we don't have it in Brisbane, I made sure to eat Taco Bell for EVERY meal.
We all got astonishingly sick, but a great time was had by all.
The most impressively useless vehicle was part of a GizmoDuck costume I made many many moons ago. Seven kilos of solid rubber wheelbarrow tyre, strapped to my foot. Couldn't really be ridden at all since the brace wasn't rigid enough for the single foot it was attached to to balance it, and there wasn't anything for my other foot to stand on on the other side or else I would have been kicking it and filling my ankle with holes all night. In hindsight I should have just gotten a unicycle.
At a party a couple of weeks ago, we drunkenly decided to play space cadets: Dice Duel (A board game where you are you team man stations in a spaceship and try to kill the other team, played in real time its great fun).
We decided to make a drinking game out of it, whenever you took damage your team needed to take a shot of tequila. We played 2 games, the first game was pretty close with one team take 3 damage and the other team taking 4. We decided to play again, both after a couple confrontations the tequila had started to kick in, before long our engineer had to tap out to lie down and our pilot was running around the circles. We lucked out and the other teams ship came into range (their pilot was also flying quite drunk) we fired both our torpedoes and scored a direct hit of their unshielded flank to win the game.
I was on my way to my very first job interview. I was all dressed up and noticed a hot guy in a bright and shiny Mitsubishi checking me out. So what do I do? I make eye contact, give him my best smile, and give a little wave before passing him in traffic. We played this flirtatious game for a few blocks before I lost him in traffic.
Guess who my very first interview was with?!?! Mr. Mitsubishi of course! His first question... "so are you always so friendly to strangers?".
The story is set a hundred years after a vehical war between Nissan Navara and Hyundai genesis, where Nissan Navara was defeated. However, the vehical war was fatal, leaving Prince Toyota and his younger half-brother Honda the only royal heirs and pure-blood vehical illusionists left in Melbourne. Conflict ensues after Toyota reluctantly ascends to the throne as his lover, Jeep, and his brother go missing.
Toyota also accidentally discovers an evil presence lurking in the Holden's holy shrine. He and his companions enter the mysterious shrine, and defeat head of the shrine, Lady Misubishi, only to find out that she has been plotting a conspiracy against him. Toyota also experiences hardships in trying to find his lover and brother, not knowing that his brother has lost all of his memories and has become the Hyundai Prince under his mother's command. A war between the two tribes commences once again, with the two brothers pitted against each other.
Broken down on the side of the hwy in my crappy P platers car, stinking hot in the middle of summer with my hood up, hazards flashing. A random car pulls up to help, braving up to this strange dude, he fixes my car ( clutch cable ) but also scores my number. 14 years, a marriage, 2 kiddies and we are still going strong. Maybe it was a blessing i broke down ?
When I was a kid, my mum worked nights. We only had one car, so every night my dad dropped her off at work. I was still too young to be left at home, so every night I was bundled up into the car, pillow in tow, fussily protesting.
I'd usually sleep on the way to Mum's work, but during the half hour trip home, Dad would play his mix tape. It was full of his favourite 70's/80's hits, and he'd crank up the volume and belt it out to Meatloaf, Queen, Bowie, like a man possessed by the rock gods he idolised in his youth.
While I've always been a heavy sleeper, I had limits, and blasting the Pet Shop Boys in a 1991 Toyota Camry is one of them. Once Dad knew I was awake, we would play a game. During the instrumental opening of a song, I had to yell out the title, artist and the first line of the song. I struggled at first. But little by little, night by night, I learnt not only the title, artist, and first line of every song in that mix tape, but all the lyrics too. We would belt it out together, on the empty roads in the middle of the night, nothing but streetlamps passing us by.
Fast forward, I'm 19 and need one more hour of night driving to go for my licence. Dad and I are in the Camry, the roads are quiet and still, just us and streetlamps. I reach over, and before he can ask, he sees the CD. As the instrumental starts, I look over and smile, "Title and Artist?"
It's been years, but when I'm driving and hear Under Pressure on the radio I can't help but break into song.
It looks like my comment was deleted so just to make sure it wasn't here is my post from last Friday :D.
Here in Western Australia we are usually ravaged by fire early on in the year, this year was no exception. Against the will of nature however there are a mighty few who are courageous enough to play music to the masses, to stand above the mighty horde and smash out a mad medley.
This time however when I (our pilot) jumped into my Ovalchase Dragster with my accompaniment of 4 dwarfs, we had no idea what would behold in front of us. We passed many the different land, plains, mountains and forests the like until we came to a stop. Thousands of other dwarf's with the same tenacity for succulent symphonic jams were in a pickle. The great demonic fires had engulfed the road ahead. The Plains-Rockers couldn't fight back the ferocity of the flames and took to their Sky Skiff's to flee, leaving us dwarfs with nothing but anguish and our Dragster radios.
We turned back towards Geraldton, got an AirBnB and drank enough mead to drown away our sorrows.
My vehicle based tale of woe took place on a fishing charter boat heading out to the Coral Sea for what turned out to be called 'The Week of Spew'.
The boat left the Gladstone docks at about 5:30 with some rough weather predicted. The rough turned out to be a 7 metre swell complete with whitecaps. I went to bed feeling a little woozy but OK. I woke about 1:00am feeling quite sick so I staggered to the head fighting the rolling deck and gripped on tight to the stainless steel toilet bowl to let fly with every meal I had eaten up to that point. Now this was an older boat, and the plumbing was a bit dodgy so here I was sitting on the floor of the toilet heaving my guts up with about 15cm of water sloshing around in the room to completely soak me as well, I wanted to die. After about 3 hours of this with sore vomiting muscles all around my body, I felt a little better so I figured rather than going to bed I would go to he galley, sip some water and sit down somewhere dry to have a rest.
NOPE... After 2 sips i was running to the side of the boat in a zig zag way as we crashed up and through the 7m water mountains and screamed down the other side. When I got to the edge I heaved over the side just at the same time as a massive 7th wave crashed into the bow of the boat. I was lucky my convulsion made every muscle in my body tighten like a steel cord, as my death grip on the gunwhale was the only thing stopping me getting a free tour of Davey Joneses locker.
Vehicles can be bad MMMKay.
It was late 2001 and I had just escaped out the back of a prison transport van in Liberty City. I was a man of few words, flat broke and had serious trust issues after being shot by my girlfriend the week before. But as the prison van slowly burned behind me illuminating the night sky I knew I could love again and that's when I saw her, the most gorgeous car in the whole city a cherry red viper. There was no time for hesitation as the traffic light was about to turn green and she we would be gone from my life forever. I ran across three lanes of traffic yanked open the door and extracted its previous owner. Without even waiting to close the door I hit the gas and speed away through the city as I gave a knowing nod to my new friend in the passenger seat who hadn't had time to exit the vehicle. Despite his screams of terror as we power slid through each corner I could feel that he knew we were about to embark on the road trip of a lifetime. Within minutes of mounting the curb and knocking down a few pedestrians, word had spread throughout the city that this road trip was going to be the stuff of legends. The police, FBI and even National Guard sent vehicles to join us on this epic adventure. Congratulatory gun fire erupted from all around us. But it soon became too much for my new love to handle as flames started to appear under her bonnet and the next thing I knew I was waking up outside the hospital as though it had never happened. I give the whole experience 6 stars.
and yes, I'm sucking up to Kotaku by mentioning Magic to get the PAX win.
Be me. 18 year old finishing HSC and planning schoolies for 8 mates. Everyone's gonna get laid because of me. Have parents who are sadists and make us catch the train to Byron Bay from Sydney. Somehow manage to get hype after 14 hours on a bum train. Get off and realise I've booked Schoolies for the wrong weekend.
So driving back down the South Coast of NSW after an awesome concert. I was driving my trusty 1984 pale blue Sigma (Aston engine! - what a ride). My mate Les suddenly got the after grog urge (you know to use a toilet and not a convenient tree - if you get my meaning).
Problem is there is nothing we can find, no petrol stations in this stretch. Then I see it, Bombo Station. I pull into the carpark, saying I was sure there would be a toilet.
There wasn't, but a train came in, heading south. Yelling to Les to get on, I pulled out back on to the Princes Highway. Ended up finding a much relieved and comfortable travelling companion at Gerringong station - it took him two stops to find the relief he needed and my Sigma's plush crushed blue seats were saved from a fate worst than death.
My wife and I were in Tokyo and while wondering the many streets around our hotel we found this old amusement park. The Hanayashiki Amusement Park in Asakusa. This old park looked so out of place, like time had stood still here while a modern city was built around it. It definitely had a horror movie feel about it! So we decided to buy tickets and have a look around, because why not we are on holidays! The place wasn't particularly run down it was just old looking and the rides looked like they barely worked. It had all the classics, ghost train, merry-go-rounds and a rollercoaster that looked like it was going to fall off the tracks at any moment. Then we found something different, something completely awesome, Panda Cars. The Panda Cars are motorised ride-on vehicles that you can use to get around the park. For only 500 Yen the Panda Car will swing its little legs, nod it fluffy little head and sing a happy tune as it takes you on an adventure around Tokyo oldest amusement park. Every day I think of my adventure with my motorised Panda friend and smile.
Attempting to impress a new girlfriend, I suggested a movie and some dinner. The movie was ok, but by the time it had finished most things had closed. Attempting to impress my lovely lady friend, I suggested we go to a Maccas…250Km away, on the other side of Tasmania. Being a non-driver, dating her first guy with a licence, she agreed and thought it would be fun.
The car trip was awesome. Despite the chilly spring night, she had her feet out the window and we had tunes blaring and it was like every road trip scene in every movie ever. We reached our destination, laughed about the fact that I'm driving her on a nearly 500 km round trip so she could eat a hamburger we literally could have got 200 metres up the street. As we travel back, Tasmania does what Tasmania does – change weather on a whim. A windy, wet storm moved in. It got worse, the closer we got to home.
I was 19, just on my P plates and not very confident driving at night, much less through a storm. But slow and steady wins the race, and I was only 20km from her house when disaster struck. I aquaplaned – not on a little street, but on a four lane non-separated highway. After what felt like ages, we stalled facing into the traffic on the other side of the highway. A truck passed us at 50km, missing us by a less than a metre.
We celebrate 13 years together next week.
I was about 6yrs old and my dad was a farm manager and they had one of the light planes that do the air fertilizer and spraying for the week. Being a kid I was excited by this and hung around every day. One the last day I was offered the chance to go along as a side kick for the last run.
He was kind enough to fly around with me in the cockpit before his run - it was the best experience of my life. Seeing my house which looked like it was for ants was amazing. He didnt barrel roll but sideways instead. I think His eardrums almost burst from all the squeeling.
In uni I've been working on a team to build a sportscar for a competition. I was in early one morning with the boss when he asked me to go check the mail box on the other side of the uni to see if any new parts had come in. The uni was prettry empty that day so let me use one of the segways we had to get there (normally they could only be used by staff). IT's a terrifying thing to ride and you start by wobbling all over the place but once I got the hang of it, it feels like you're in the future and they handle like a dream. The whole experience was incredible, despite the fact that I fell flat on my face trying to get off it at the end. The car is still under construction and will hopefully be finished by the end of the year.


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Back to Journals » Drug Design, Development and Therapy » Volume 9
Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells
Authors Xiukun Lin X, Farooqi A, Ismail M
Received 11 November 2014
Accepted for publication 6 January 2015
Published 26 March 2015 Volume 2015:9 Pages 1797—1804
DOI https://doi.org/10.2147/DDDT.S77341
Editor who approved publication: Professor Shu-Feng Zhou
Xiukun Lin,1 Ammad Ahmad Farooqi,2 Muhammad Ismail2
1Department of Pharmacology, Capital Medical University, Beijing, People's Republic of China; 2Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan
Abstract: It is becoming increasingly understood that tumor cells may have different mutations and dependencies on diverse intracellular signaling cascades for survival or metastatic potential. Overexpression of oncogenes, inactivation of tumor suppressor genes, genetic/epigenetic mutations, genomic instability, and loss of apoptotic cell death are some of the mechanisms that have been widely investigated in molecular oncology. We partition this multicomponent review into the most recent evidence on the anticancer activity of fungal substances obtained from in vitro and xenografted models, and these fungal substances modulate expression of oncogenic and tumor suppressor miRNAs. There are some outstanding questions regarding fungus-derived chemical-induced modulation of intracellular signaling networks in different cancer cell lines and preclinical models. Certain hints have emerged, emphasizing mechanisms via which apoptosis can be restored in TRAIL-resistant cancer cells. Reconceptualization of the knowledge obtained from these emerging areas of research will enable us to potentially identify natural agents with notable anticancer activity and minimal off-target effects. Integration of experimentally verified evidence obtained from cancer cell line gene expression with large-scale functional screening results and pharmacological sensitivity data will be helpful in identification of therapeutics with substantial efficacy. New tools and technologies will further deepen our understanding of the signaling networks that underlie the development of cancer, metastasis, and resistance to different therapeutics at both a personal and systems-wide level.
Keywords: fungal products, cell signaling, cancer, apoptosis, miRNA, xenograft
High-throughput technologies have revolutionized our current understanding of the genomically complex nature of cancer. Phenomenal breakthroughs have been made in the field of molecular oncology, as evidenced by advancements in genetics, genomics, and proteomics. With overwhelmingly expanding information about cancer, it is now more understandable that overexpression of oncogenes, inactivation of tumor suppressor genes, genetic/epigenetic mutations, genomic instability, dysregulation of spatiotemporally controlled intracellular signaling cascades, and loss of apoptotic cell death are some of the mechanisms that underlie the development and progression of cancer. Rapidly accumulating experimentally verified data are deepening our knowledge about wide-ranging mechanisms that induce resistance against different therapeutic agents. It is noteworthy that bioactive ingredients isolated from natural sources are now widely appreciated.
Anticancer activity of bioactive fungal components: in vitro and in vivo evidence
The polysaccharide fraction purified from a culture broth of Ganoderma formosanum has been shown to have notable anticancer activity. When administered intraperitoneally or orally, the polysaccharide fraction efficiently inhibited tumor growth in xenografted mice. It is noteworthy that the growth inhibitory effects exerted by the polysaccharide fraction were impaired in severe combined immunodeficiency (SCID) mice. CD4+ T-cells and CD8+ T-cells were noted to be essential for the polysaccharide fraction-mediated tumor growth-retarding effects.1
Wnt signaling cascade
Wnt-induced intracellular signaling is an extensively studied mechanism reported to underpin the development and progression of cancer. β-catenin, a well-known downstream effector, is reported to be modulated by positive and negative regulators, and phosphorylated β-catenin is degraded via the ubiquitin pathway. Different regulators have been noted to control β-catenin, including axin, adenomatous polyposis coli, casein kinase, and glycogen synthase kinase (GSK)-3β. Wnt-induced intracellular signaling sequesters β-catenin from GSK-3β and promotes its accumulation in the nucleus, where β-catenin works synchronously with T-cell factor/lymphocyte enhancer binding factor to stimulate expression of target genes. Cordycepin isolated from Cordyceps sinensis, a parasitic fungus, has been shown to decrease protein levels as well as nuclear accumulation of β-catenin. Cordycepin exerted its biological effects by enhancing GSK-3β-mediated phosphorylation of β-catenin, and these effects were impaired in cells treated with GSK-3β inhibitors. Moreover, phosphatidylinositol-4 5-bisphosphate 3-kinase (PI3K)/Akt-mediated inactivation of GSK-3β was also inhibited, as evidenced by a decrease in phospho-Akt levels.2 Protein-bound polysaccharide isolated from Phellinus linteus also efficiently reduced β-catenin and its target gene in SW480 colon cancer cells overexpressing β-catenin (Figure 1). Protein-bound polysaccharide inhibited T-cell factor/lymphocyte enhancer binding factor reporter activity in SW480 cells transiently transfected with a luciferase reporter construct.3 Destruxin B isolated from Metarhizium anisopliae has also been found to inhibit the Wnt signaling pathway. β-catenin/Tcf4 transcriptional activity was also marked inhibited in destruxin B-treated HCT116 and SW480 cells4 (Figure 1). Antrodia camphorata grows on germinated brown rice and recently it has been reported that ethanolic extract is effective against HT-29 colon cancer cells. Ethanolic extract was further characterized and ethyl acetate-mediated anticancer activity was more pronounced. The β-catenin pathway was notably inhibited in cancer cells treated with ethyl acetate.5
Figure 1 Wnt-induced intracellular signaling and fungal product-mediated inhibition of nuclear accumulation of β-catenin and transcriptional upregulation of target genes.
TGF signaling
A confluence of information indicates that fungal lactones, ie, (S)-curvularin, oxacyclododecindione, dehydrocurvularin, and galiellalactone, considerably inhibit transforming growth factor (TGF)-induced intracellular signaling, and SMAD2/3-mediated stimulation of the transcriptional network was also reduced in MDA-MB-231 and HepG2 cells (Figure 2).6 Circumstantial evidence also indicates that TGF-induced intracellular activation of SMAD2/3 is dramatically reduced in MDA-MB-231 and HepG2 cells treated with trichodimerol (a fungal metabolite).7 Cordycepin isolated from Cordyceps militaris effectively reduced production of IL-2 and TGF-β in mice xenografted with cancer cells.8
Figure 2 Transforming growth factor-induced intracellular signaling and fungal product-mediated inhibition of nuclear accumulation of SMAD and transcriptional upregulation of target genes.
Abbreviation: TGFR, transforming growth factor receptor.
NF-κB signaling
Nuclear factor kappa B (NF-κB, p65 and p50) is cytosolic and coexists with its inhibitor, IκB kinase. Trichothecin, a metabolite isolated from an endophytic fungus, is a potent inhibitor of trichothecin and its target genes. Detailed mechanistic insights indicated that inhibition of IκB kinase-mediated phosphorylation of IκBα facilitated sequestration and nuclear accumulation of p65. NF-κB triggered expression of XIAP, cyclin D1, and Bcl-xL. However, treatment with trichothecin dramatically reduced IκBα phosphorylation and nuclear accumulation of NF-κB. Enforced expression of constitutively active IκB kinase-β considerably reduced trichothecin-induced apoptosis.9 Western blot analysis confirmed a decrease in IκB kinase, p50, and p65 protein levels in fumigaclavine-treated MCF-7 cells.10 Destruxin B isolated from M. anisopliae inhibited IκB kinase-α and NF-κB, and interestingly the IκBα level was enhanced.4
PI3K/Akt signaling pathway
Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine/threonine kinase reported to modulate wide-ranging downstream effectors, particularly PI3K and Akt. It is now known that ligand-binding sites present in the PDK1 kinase domain can be targeted using different natural agents. Neoalbaconol, a novel molecule isolated from the Albatrellus confluens fungus, has been shown to dock into the PDK1 adenosine triphosphate-binding pocket, thus forming hydrogen bonds with the PDK1 backbone. This inhibition abrogated PDK1-mediated levels of phospho-Akt at the 308th and 473rd serine residues in C666-1 nasopharyngeal carcinoma cells.11 PI3K-mediated phosphorylation of Akt was also inhibited in fumigaclavine-treated MCF-7 cells.10 Destruxin B isolated from M. anisopliae inhibited the PI3K/Akt pathway by reducing Akt expression.4 Extract of Pleurotus pulmonarius also inhibited phosphor-Akt levels, and enforced expression of constitutively active Akt impaired the extract-mediated inhibitory effects on Huh7 and Hep3B liver cancer cells. Moreover, sensitivity to cisplatin was enhanced in cancer cells treated with the extract.12 Ochratoxin, a secondary metabolite of Penicillium, has recently been noted to potentiate carcinogenesis. It was shown mechanistically that ochratoxin-treated cells displayed active PI3K/Akt and MEK/ERK1–2 intracellular signaling cascades. It was further shown that c-Met, a cell surface receptor, was also functionally active upon treatment of cells with ochratoxin.13 There is a recent report suggesting that sterigmatocystin in combination with ochratoxin or citrinin worked with effective synergy against Hep3B hepatocellular cancer cells.14
MMPs: novel targets of fungal products
Contemporary studies indicated that 3-O-methylfunicone dramatically reduced αVβ5 integrin and matrix metalloproteinase (MMP)-2 expression by exerting inhibitory effects on ERK-mediated signaling in human mesothelioma cells.15 Fumigaclavine C, a chemical isolated from Aspergillus fumigatus, also efficiently targeted MMPs. MMP-2 and MMP-9 protein expression was remarkably reduced in fumigaclavine-treated MCF-7 cells. The decrease in MMPs reduced the migratory and invasive potential of MCF-7 cells. ERK, JNK, and p38 mitogen-activated protein kinase (MAPK) are also targeted by fumigaclavine, as evidenced by reduced phospho-ERK, JNK, and p38 MAPK levels in fumigaclavine-treated MCF-7 cells.10 Protein-bound polysaccharide isolated from P. linteus and destruxin B isolated from M. anisopliae exerted inhibitory effects on MMP-2 and MMP-9 activity in HT1080 and SW480 colon cancer cells.3,4 Cordycepin and zhankuic acid, isolated from Antrodia cinnamomea, considerably enhanced tissue inhibitors of MMP (TIMP-1 and TIMP-2) in CL1-0 lung adenocarcinoma cells.16
Cyclins and cyclin-dependent kinases
Mitogenic signals promote heterodimerization of cyclin D1 and cyclin E1 with cyclin-dependent kinase (CDK)-4 and CDK-2, respectively. These phosphorylate the Rb proteins, causing release of E2Fs. Cyclin E is also a target gene of E2F that later complexes with CDK-2 to phosphorylate Rb. Fumigaclavine-treated MCF-7 breast cancer cells displayed a marked decrease in CDK-2, CDK-4, and cyclin E protein expression levels.10 Moreover, the fungus-derived compound cephalochromin downregulated cyclin D1, cyclin E, CDK-2, and CDK-4 in A549 lung cancer cells, thus abrogating the association of cyclins with their respective CDKs.17
Targeting of negative regulators of death signaling
Paxilline, isolated from Penicillium paxilli, has been shown to effectively induce apoptosis in TRAIL-resistant glioma cell lines. Paxilline-treated glioma cells displayed a marked increase in the TRAIL receptor, DR5. Interestingly, paxilline markedly reduced cellular levels of FLICE-inhibitory protein and survivin by potentiating proteasome-triggered degradation.18 Fungus-derived cephalochromin effectively reduced Bcl-xL and survivin expression and activated caspase-3 via caspase-8 and caspase-9 in A549 lung cancer cells.17 Caspase-8-mediated proteolytically cleaved truncated Bid and Bax were also elevated in DU145 prostate cancer cells treated with glionitrin A, isolated from A. fumigatus.19
Verrucarin A, isolated from Myrothecium verrucaria, is a protein synthesis inhibitor reported to activate caspase-3 and upregulate Bax in MDA-MB-231 and T47D breast cancer cells. Moreover, Bcl-2 expression was notably reduced in verrucarin-treated breast cancer cells.20 The ratio of Bax to Bcl-2 was also enhanced in human laryngeal carcinoma cells treated with polysaccharides of Lepista sordida. Release of cytochrome c was noted in Hep-2 cells along with a marked increase in caspase-9 activity.21
Fungal products awake "guardian angels"
Polysaccharides isolated from Ganoderma atrum considerably enhanced cell surface expression of Toll-like receptor-4 in macrophages and induced intracellular signaling. Moreover, there was evident nuclear accumulation of the p65 subunit of NF-κB and degradation of IκBα. Further, phosphorylated levels of p38-MAPK, ERK-1/2, and c-JNK were also increased in macrophages.22 In another study, a similar mode of action was demonstrated, as polysaccharides did not kill CT26 colorectal carcinoma cells directly but exerted inhibitory effects on proliferation of CT26 cells by activating peritoneal macrophages. Tumor growth was also remarkably inhibited in mice with CT26 xenografts.23
mTOR signaling
Extract of Ganoderma lucidum efficiently decreased levels of phospho-mTOR (mammalian target of rapamycin) and its downstream effectors, including p70S6K, S6, p-S6, and p-4E-BP1, in SUM-149 inflammatory breast cancer cells.24 Monascuspiloin efficiently induced apoptosis in LNCaP prostate cancer cells by inhibiting PI3K/Akt/mTOR-induced downstream signaling.25 Antrocin isolated from A. camphorata decreased phospho-Akt and phospho-mTOR levels in MDA-MB-231 cells.26
Targeting of Rho GDP dissociation inhibitor
RHO-specific guanine nucleotide dissociation inhibitors (RHoGDIs) have emerged as versatile regulators of RHO proteins and are reported to protect RHO proteins from degradation. It has previously been convincingly demonstrated that secalonic acid isolated from Penicillium spp. considerably enhanced caspase-3-mediated cleavage of RhoGDI 2. Secalonic acid-treated HL60 cells displayed a marked increase in the cleaved product of RhoGDI 2.27 Alcohol extracts of A. camphorata mycelia also downregulated RhoGDI-α expression in A549 lung carcinoma cells.28
VEGF-induced signaling
Vascular endothelial growth factor (VEGF) is a proangiogenic molecule for vascular endothelial cells and a potent vascular permeability enhancer. Mounting evidence indicates that VEGF has a key role during angiogenesis, proliferation, and migration of endothelial cells. Toluquinol exerted inhibitory effects on VEGF-induced and fibroblast growth factor-induced intracellular signaling. Interestingly, it has been suggested that capillary tube formation of endothelial cells on Matrigel is substantially reduced upon treatment with toluquinol, a methylhydroquinone isolated from a marine fungus. Additionally, the invasive, migratory and proteolytic activities of endothelial cells were also suppressed.29 Cytochalasin isolated from Diplodia macrospora efficiently inhibited positioning of hypoxia-inducible factor-1α at the VEGF promoter in ovarian cancer cells.30 Arthrinins isolated from Arthrinium spp. markedly inhibited VEGF receptor-2 in cancer cells.31
Preliminary results for fungal products
Citriquinone is a benzoquinone isolated from Penicillium citrinum and has notable activity against cancer cells.32 Chaetoglobosin, a secondary metabolite isolated from Penicillium aquamarinium, effectively induced cell cycle arrest and apoptosis in leukemia cells. It was also noted to exert inhibitory effects on cell migration and membrane ruffling.33 Diterpene alkaloids known as penitrems are also bioactive ingredients isolated from Penicillium with considerable anticancer activity against MCF-7 breast cancer cells.34 Fermented ginseng extracts isolated from Penicillium simplicissimum have activity against ES2 human clear-cell ovarian carcinoma cells.35 Eremophilane-type sesquiterpenes isolated from Penicillium spp. have activity against A-549 cancer cells.36 Dihydrothiophene-condensed chromone isolated from Penicillium oxalicum is effective against SW-620, A375, and HeLa cancer cells.37 There is a direct piece of evidence highlighting the autophagic cell death-inducing role of peneciraistin, a spiroketal molecule isolated from Penicillium raistrickii, in A549 lung cancer cells. Moreover, use of autophagy inhibitors induced apoptotic cell death in A549 cells.38 It is noteworthy that the mammosphere-forming ability of MCF-7 cells decreased significantly upon treatment with the 3-O-methylfunicone metabolite isolated from Penicillium pinophilum.39 Patulin isolated from Penicillium spp. has been shown to induce activation of caspase-3 and to considerably enhance levels of phospho-EGR-1; indepth analysis revealed an EGR-1-mediated increase in expression of ATF3 in colorectal cancer cells.40
miRNA regulation
miRNA is a non-coding RNA consisting of 21–22 nucleotides. The RNA polymerase binds to the promoter region of a specific DNA sequence and forms a hairpin structure of the pri-miRNA. The pri-miRNA is recognized by nuclear protein DGCR8. DGCR8 works synchronously with Drosha by cleaving nucleotides from hair pin of pri-miRNA to form pre-miRNA. This "pre-miRNA" transcript has the capacity to form a stem-loop structure, and is then processed into 21–22 nucleotide long miRNA by an enzyme called Dicer. Increasingly, it is being realized that miRNAs regulate other genes by binding to complementary sequences in the target gene. Perfect complementarity of binding leads to mRNA degradation of the target gene. Imperfect pairing inhibits translation of mRNA to protein. miRNAs have emerged as master regulators of the gene network.
Diaporine A (D261), a natural product of endophytic fungus, has been shown to effectively inhibit proliferation of non-small cell lung cancer cells by upregulating expression of miR-99a. It was shown mechanistically that miR-99a quantitatively controlled expression of mTOR. Diaporine A also induced regression of tumor growth in mice xenografted with NCI-H460 non-small cell lung cancer cells.41 Antrocin, a sesquiterpene lactone isolated from A. camphorata, a medicinal mushroom, considerably inhibited interleukin 6-induced activation of STAT3, constitutive activation of STAT-3, and its nuclear accumulation. Let-7c was markedly increased in antrocin-treated cancer cells. More importantly, intraperitoneally administered antrocin induced regression of tumor growth in lung cancer tumor xenografts.42
Bostrycin, isolated from marine fungi, considerably upregulated miR-923 and miR-638 in A549 lung carcinoma cells.43 miR-638 is known to suppress progression of cancer, as evidenced by cell culture studies. Future studies should focus on identifying the potential protein network involved in cancer progression.
A. cinnamomea, a medicinal fungus, has considerable efficacy against SK-Hep-1 liver cancer cells. The MAPK and PI3K/Akt signaling cascades were extensively reduced in SK-Hep-1 cells treated with extracts of A. cinnamomea. Surprisingly, the oncomirs miR-21 and miR-191, together with oncogenic clusters miR-106b-25 and miR-17-92, were effectively downregulated in SK-Hep-1 cells.44
Trametes robiniophila murris (Huaier) is a fungus with notable anticancer activity. Recently, it has been shown that Huaier stimulates expression of miR-26b-5p in A549 pulmonary adenocarcinoma cells. A549 cells transfected with miR-26b-5p displayed a higher apoptotic rate, and targeted inhibition of miR-26b-5p in A549 cells dramatically abrogated the Huaier-mediated anticancer effects. It was shown mechanistically that miR-26b-5p negatively regulated EZH2 in A549 cells.45
Pharmacokinetic studies
Aspergiolide (ASP)-A, an anthracycline isolated from a marine fungus, significantly inhibited tumor growth in H22 hepatoma-bearing mice. The distribution and pharmacokinetic parameters of ASP-A were studied by intraperitoneal injection of 15 mg/kg and 30 mg/kg of ASP-A at varying times. ASP-A achieved an effective concentration of drug and was noted to be broadly redistributed in vivo with a shorter half-life.46 Xyloketal B, isolated from Xylaria spp. (mangrove fungus), exerted inhibitory effects on cytochrome P450 (CYP)3A-mediated metabolism of midazolam in rats by markedly reducing hepatic CYP3A activity and expression. Xyloketal B may behave as a CYP3A4/Cyp3A2 substrate and/or inhibitor, which dramatically alters the pharmacokinetics of CYP3A4/Cyp3a2-mediated metabolism of coadministered drugs.47
Schizophyllan (SPG) has previously been used in combination with conventional chemotherapy in a randomized controlled trial including 367 patients with inoperable recurrent gastric cancer, resulting in a considerable increase in median survival. SPG in combination with radiotherapy notably improved the time to recurrence and survival time in patients with stage II cervical cancer in this randomized controlled trial but not in those with stage III disease.48,49 In a prospective, randomized controlled trial involving 312 patients treated with surgery, chemotherapy (5-fluorouracil), radiotherapy, and SPG in various combinations, survival rates were notably longer in SPG-treated patients than in those who did not receive SPG. It is noteworthy that a markedly increased proportion of CD8+ cells (HLA-DR+) activation from total CD8+ subset was evident with progressing disease. SPG-induced acceleration was observed in terms of recovery of activated CD8+ T-cells in the CD8+ T-cell subsets when compared with patients not treated with sizofiran (SPG) after radiotherapy.50 SPG was also tested for efficacy in 15 patients with head and neck cancer, and the SPG-treated group had an 86.7% cumulative 5-year survival rate.51
Basidiomycetes are a rich source of natural agents and a widely studied product is the protein-bound polysaccharide, PSK (Krestin®), with notable biological activity. There is a surprising piece of evidence suggesting that PSK-mediated anticancer effects were not significant either in early-stage cancers or in more advanced cases (>S3 or >N3) in patients treated combinatorially with carbazilquinone + PSK. However, survival of patients whose disease was classified as S1 + S2(N1-2) was better on treatment with carbazilquinone + PSK.52
In a randomized double-blind trial, PSK was given to colorectal cancer patients, and the results revealed improved disease-free survival (P<0.05) and overall survival (P<0.05) rates in the PSK group. Importantly, analysis of patients with polymorphonuclear leukocytes and undergoing treatment with PSK indicated notable biological activity, such as phagocytosis and chemotactic locomotion.53 There is also a direct piece of evidence suggesting that the 5-year disease-free survival rate was considerably high (73.0%) in a group treated with chemotherapy + PSK when compared to that in patients treated with chemotherapy alone. Disease recurrence was reduced by 43.6% (95% confidence interval [CI] 4.5–66) and mortality by 40.2% (95% CI −12.5, 68.3) in the PSK-treated group. Disease-free survival and overall survival in PSK-treated patients with stage III disease increased significantly, with a notable decrease in recurrence, particularly of lung metastases.54
Meta-analysis of three randomized controlled trials conducted in patients who had undergone curative resection also highlighted the effective role of PSK. A comparative analysis of chemotherapy alone and chemotherapy + PSK concluded that the disease-free survival risk ratio was 0.72 (95% CI 0.58–0.90, P=0.003) and the overall survival risk ratio was 0.71 (95% CI 0.55–0.90, P=0.006), thus signifying notable survival rates because of the effective synergy induced by the combinatorial approach.55
Rapidly developing resistance against a wide range of therapeutic interventions has added another layer of complexity and future studies must focus on identification of natural agents with clear anticancer activity. Fungal products have been shown to have considerable potential in delaying the progression of cancer and induction of apoptosis, as evidenced by in vitro and in vivo studies. It is becoming increasingly evident that fungal products can modulate the intracellular protein network, and a better understanding of the different cancers and their subtypes will be helpful in identification of most efficient bioactive ingredients will minimal off-target effects.
Wang CL, Lu CY, Hsueh YC, Liu WH, Chen CJ. Activation of antitumor immune responses by Ganoderma formosanum polysaccharides in tumor-bearing mice. Appl Microbiol Biotechnol. 2014;98(22):9389–9398.
Ko BS, Lu YJ, Yao WL, et al. Cordycepin regulates GSK-3β/β-catenin signaling in human leukemia cells. PLoS One. 2013;8(9):e76320.
Song KS, Li G, Kim JS, et al. Protein-bound polysaccharide from Phellinus linteus inhibits tumor growth, invasion, and angiogenesis and alters Wnt/β-catenin in SW480 human colon cancer cells. BMC Cancer. 2011;11:307.
Yeh CT, Rao YK, Ye M, et al. Preclinical evaluation of destruxin B as a novel Wnt signaling target suppressing proliferation and metastasis of colorectal cancer using non-invasive bioluminescence imaging. Toxicol Appl Pharmacol. 2012;261(1):31–41.
Park DK, Lim YH, Park HJ. Antrodia camphorata grown on germinated brown rice inhibits HT-29 human colon carcinoma proliferation through inducing G0/G1 phase arrest and apoptosis by targeting the β-catenin signaling. J Med Food. 2013;16(8):681–691.
Rudolph K, Serwe A, Erkel G. Inhibition of TGF-β signaling by the fungal lactones (S)-curvularin, dehydrocurvularin, oxacyclododecindione and galiellalactone. Cytokine. 2013;61(1):285–296.
Serwe A, Anke T, Erkel G. The fungal secondary metabolite trichodimerol inhibits TGF-β dependent cellular effects and tube formation of MDA-MB-231 cells. Invest New Drugs. 2009;27(6):491–502.
Jeong MH, Lee CM, Lee SW, et al. Cordycepin-enriched Cordyceps militaris induces immunomodulation and tumor growth delay in mouse-derived breast cancer. Oncol Rep. 2013;30(4):1996–2002.
Su J, Zhao P, Kong L, et al. Trichothecin induces cell death in NF-κB constitutively activated human cancer cells via inhibition of IKKβ phosphorylation. PLoS One. 2013;8(8):e71333.
Li YX, Himaya SW, Dewapriya P, Zhang C, Kim SK. Fumigaclavine C from a marine-derived fungus Aspergillus fumigatus induces apoptosis in MCF-7 breast cancer cells. Mar Drugs. 2013;11(12):5063–5086.
Deng Q, Yu X, Xiao L, et al. Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway. Cell Death Dis. 2013;4:e804.
Xu W, Huang JJ, Cheung PC. Extract of Pleurotus pulmonarius suppresses liver cancer development and progression through inhibition of VEGF-induced PI3K/AKT signaling pathway. PLoS One. 2012;7(3):e34406.
Ozcan Z, Gül G, Yaman I. Ochratoxin A activates opposing c-MET/PI3K/Akt and MAPK/ERK 1–2 pathways in human proximal tubule HK-2 cells. Arch Toxicol. July 8, 2014. [Epub ahead of print].
Anninou N, Chatzaki E, Papachristou F, et al. Mycotoxins' activity at toxic and sub-toxic concentrations: differential cytotoxic and genotoxic effects of single and combined administration of sterigmatocystin, ochratoxin A and citrinin on the hepatocellular cancer cell line Hep3B. Int J Environ Res Public Health. 2014;11(2):1855–1872.
Buommino E, Paoletti I, De Filippis A, et al. 3-O-Methylfunicone, a metabolite produced by Penicillium pinophilum, modulates ERK1/2 activity, affecting cell motility of human mesothelioma cells. Cell Prolif. 2010;43(2):114–123.
Chen YY, Chou PY, Chien YC, Wu CH, Wu TS, Sheu MJ. Ethanol extracts of fruiting bodies of Antrodia cinnamomea exhibit anti-migration action in human adenocarcinoma CL1-0 cells through the MAPK and PI3K/AKT signaling pathways. Phytomedicine. 2012;19(8–9):768–778.
Hsiao CJ, Hsiao G, Chen WL, et al. Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption. J Nat Prod. 2014;77(4):758–765.
Kang YJ, Kim IY, Kim EH, et al. Paxilline enhances TRAIL-mediated apoptosis of glioma cells via modulation of c-FLIP, survivin and DR5. Exp Mol Med. 2011;43(1):24–34.
Kim YJ, Park HB, Yoo JH, Kwon HC, Kim J, Yang HO. Glionitrin A, a new diketopiperazine disulfide, activates ATM-ATR-Chk1/2 via 53BP1 phosphorylation in DU145 cells and shows antitumor effect in xenograft model. Biol Pharm Bull. 2014;37(3):378–386.
Palanivel K, Kanimozhi V, Kadalmani B, Akbarsha MA. Verrucarin A, a protein synthesis inhibitor, induces growth inhibition and apoptosis in breast cancer cell lines MDA-MB-231 and T47D. Biotechnol Lett. 2013;35(9):1395–1403.
Miao S, Mao X, Pei R, et al. Lepista sordida polysaccharide induces apoptosis of Hep-2 cancer cells via mitochondrial pathway. Int J Biol Macromol. 2013;61:97–101.
Zhang S, Nie S, Huang D, Huang J, Wang Y, Xie M. Polysaccharide from Ganoderma atrum evokes antitumor activity via Toll-like receptor 4-mediated NF-κB and mitogen-activated protein kinase signaling pathways. J Agric Food Chem. 2013;61(15):3676–3682.
Zhang S, Nie S, Huang D, Li W, Xie M. Immunomodulatory effect of Ganoderma atrum polysaccharide on CT26 tumor-bearing mice. Food Chem. 2013;136(3–4):1213–1219.
Suarez-Arroyo IJ, Rosario-Acevedo R, Aguilar-Perez A, et al. Anti-tumor effects of Ganoderma lucidum (reishi) in inflammatory breast cancer in in vivo and in vitro models. PLoS One. 2013;8(2):e57431.
Chen RJ, Hung CM, Chen YL, Wu MD, Yuan GF, Wang YJ. Monascuspiloin induces apoptosis and autophagic cell death in human prostate cancer cells via the Akt and AMPK signaling pathways. J Agric Food Chem. 2012;60(29):7185–7193.
Rao YK, Wu AT, Geethangili M, et al. Identification of antrocin from Antrodia camphorata as a selective and novel class of small molecule inhibitor of Akt/mTOR signaling in metastatic breast cancer MDA-MB-231 cells. Chem Res Toxicol. 2011;24(2):238–245.
Li N, Yi Z, Wang Y, et al. Differential proteomic analysis of HL60 cells treated with secalonic acid F reveals caspase 3-induced cleavage of Rho GDP dissociation inhibitor 2. Oncol Rep. 2012;28(6):2016–2022.
Chan YY, Chang CS, Chien LH, Wu TF. Apoptotic effects of a high performance liquid chromatography (HPLC) fraction of Antrodia camphorata mycelia are mediated by down-regulation of the expressions of four tumor-related genes in human non-small cell lung carcinoma A549 cell. J Ethnopharmacol. 2010;127(3):652–661.
García-Caballero M, Marí-Beffa M, Cañedo L, et al. Toluquinol, a marine fungus metabolite, is a new angiosuppressor that interferes with the Akt pathway. Biochem Pharmacol. 2013;85(12):1727–1740.
Luo H, Li B, Li Z, Cutler SJ, Rankin GO, Chen YC. Chaetoglobosin K inhibits tumor angiogenesis through downregulation of vascular epithelial growth factor-binding hypoxia-inducible factor 1α. Anticancer Drugs. 2013;24(7):715–724.
Ebada SS, Schulz B, Wray V, et al. Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. Bioorg Med Chem. 2011;19(15):4644–4651.
Ranji PK, Wijeyaratne SC, Jayawardana KH, Gunaherath GM. Citriquinones A and B, new benzoquinones from Penicillium citrinum. Nat Prod Commun. 2013;8(10):1431–1434.
Knudsen PB, Hanna B, Ohl S, et al. Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton. Leukemia. 2014;28(6):1289–1298.
Sallam AA, Houssen WE, Gissendanner CR, Orabi KY, Foudah AI, El Sayed KA. Bioguided discovery and pharmacophore modeling of the mycotoxic indole diterpene alkaloids penitrems as breast cancer proliferation, migration, and invasion inhibitors. Medchemcomm. 2013;4(10).
Fu Y, Yin Z, Wu L, Yin C. Fermentation of ginseng extracts by Penicillium simplicissimum GS33 and anti-ovarian cancer activity of fermented products. World J Microbiol Biotechnol. 2014;30(3):1019–1025.
Lin A, Wu G, Gu Q, Zhu T, Li D. New eremophilane-type sesquiterpenes from an Antarctic deep sea derived fungus, Penicillium sp. PR19 N-1. Arch Pharm Res. 2014;37(7):839–844.
Sun YL, Bao J, Liu KS, et al. Cytotoxic dihydrothiophene-condensed chromones from the marine-derived fungus Penicillium oxalicum. Planta Med. 2013;79(15):1474–1479.
Pan X, Liu D, Wang J, et al. Peneciraistin C induces caspase-independent autophagic cell death through mitochondrial-derived reactive oxygen species production in lung cancer cells. Cancer Sci. 2013;104(11):1476–1482.
Buommino E, Tirino V, De Filippis A, et al. 3-O-methylfunicone, from Penicillium pinophilum, is a selective inhibitor of breast cancer stem cells. Cell Prolif. 2011;44(5):401–409.
Kwon O, Soung NK, Thimmegowda NR, et al. Patulin induces colorectal cancer cells apoptosis through EGR-1 dependent ATF3 up-regulation. Cell Signal. 2012;24(4):943–950.
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After extensive analysis of the mobile market, we have developed a test matrix for testing on mobile devices. The device lists take OSes, manufacturers, screen sizes, and much more into consideration, offering the best market coverage across smartphones and tablets.
Check out our device test matrix page for more information.


Selecting your test system is only half the test solution. The other half requires designing an appropriate interface to connect with your product. And interfacing with your product under test often presents unique challenges. DIT-MCO's Special Products Group has a long track record of providing practical solutions that will exceed your expectations.
A fixture often is required to test many large, complex products. Fixtures frequently utilize a spring probe interface and press mechanism to contact the product. Whether you are testing circuit boards, wired assemblies, or backpanels, DIT-MCO can develop a workable solution. Our engineers have designed fixtures for a few hundred test points to 100,000 test points.
The DIT-MCO team also will work directly with your engineers to design and develop heavy-duty tooling for your facility.
For one customer this meant motorized-driven boom assemblies mounted on a trailer to support and position the bundled interface cables. This was essential for a final aircraft test application that involved cables weighing more than three tons that were hoisted to 18 feet during testing.
Cable handling management for this application meant designing and manufacturing flexible mobile "arms." This approach facilitated easier hook-up and storage of cumbersome cable harnesses.
Let DIT-MCO's Special Products Group design a solution to meet your needs.


text:
Les Longmire Buildings sont trois bâtiments américains à Longmire, dans les comtés de Lewis et Pierce, dans l'État de Washington. Protégé au sein du parc national du mont Rainier, cet ensemble architectural érigé à compter de 1927 est inscrit au Registre national des lieux historiques et classé National Historic Landmark depuis le .

Caractérisé par son emploi du style rustique du National Park Service, il est composé du Longmire Administration Building, du Longmire Community Building et enfin de la Longmire Service Station, une station-service. Ces trois bâtiments sont chacun des propriétés contributrices au district historique de Longmire depuis la création de ce district historique le .

Liens externes

Architecture rustique du National Park Service dans le parc national du mont Rainier
Registre national des lieux historiques dans le comté de Lewis (Washington)
Registre national des lieux historiques dans le comté de Pierce (Washington)
Registre national des lieux historiques dans le parc national du mont Rainier
Registre national des lieux historiques en 1987
National Historic Landmark dans l'État de Washington
National Historic Landmark dans un parc national
National Historic Landmark en 1987
Longmire

redpajama_set_name: RedPajamaWikipedia


ICloud :: Pictures Taken On IPod Touch Not Show Up In Photostream On Mac?
When I take a photo on my ipod touch why doesn't it show in photo stream on my Mac Mini or IPad 2. They all have the same ICloud account attached?
ICloud :: Sharing Photostream Library?
ICloud :: Photostream Permanently Saved In IPhoto?
Our company recently switched to MacBook Pro computers.� When I got mine I took it on vacation and uploaded pictures on it, and have the pictures on iCloud through PhotoStream.� My company then installed software that encrypts the Mac, and also has a policy where I can't install iPhoto.
I can still see the pictures through my iPad on PhotoStream which is good.� Is there any way possible to download my pictures from PhotoStream to another computer?I've tried to do it using my wife's MacBook Pro (and setting it with my iCloud settings), and on a PC laptop, but it seems like if it's in iCloud, and the computer you're on didn't upload it, you can't download it or even see it.
I just purchased a new iMac. I moved my iPhoto library over from my MacBook. Then I enabled Photostream and now it says it is downloading 26,000 pictures to photostream. It has been spinning (in process) for a long time.
How do I select only the photos I want to photo stream, whenever I delete the ones I don't want it automatically adds a whole bunch more that I don't want. I would like to drag only selected pictures to photo stream but that doesn't seem to be an option.
I imported a photo into iPhoto. If I click on it, click actions and share to Photostream, I get a message saying it is already in Photostream. Yet, it does not show up in the iPhoto Photostream folder on my Mac. Nor does it show up in my iPhone Photostream folder. I believe I have iCloud set up properly on both devices and have configured iPhoto correctly. Is there something I can do to force a sync?
My Photostream doesn't show up on my iPhoto. Does anyone know why it won't show?
Messages keeps switching the conversation view from "Show Names and Pictures" to just "Show Pictures". This is in the menu under: View > Messages > Show Names and Pictures. I have to change it multiple times a day, including every time I open the app from a closed state.
I have a PC right now, but I was thinking of getting a MacBook Air.
I also have an iPhone and iPad with iCloud enabled and was wondering how these three things would interact.
1) Would my calendars all sync to iCal on the Mac so that they all were the same?
2) Would my mail also be synced with the Mac's Mail app through my iCloud e-mail?
3) How does PhotoStream work on the Mac? Does it get downloaded to a folder automatically?
4) How do my documents work with Pages, Keynote and Numbers? Can I sync them to iCloud on the 5 GB of space and then work on them on my iOS devices from where I left off?
5) Will all my contacts sync into the Mac?
6) Will my Safari bookmakrs be synced?
I'm suspecting the answer is NO. I have pictures that are shared via Photostream, appearing on both my iPhone and my iPad. My wife has her own iPhone & ID. and it would be really nice if our photos could all be part of one big happy family, with my photos appearing on her iPhone and vice-versa.
As I said...even though I never used MobileMe, looks like something I really wish could happen.
I dont see photostream on iCloud on my iMac, though it works wonderfully on my other devices iPhone and iPad. I also can't see any related setting in iCloud, except to reset photo stream, which deletes all photos currently on it.
How do I do that? My computer just doesn't want to.
is it possible to access photostream online??
I have a question about photostream. Is it true that ALL photos in my photo stream are permanently saved in iPhoto (even without me moving into events which i would probably do twice a month)? If the event i can't move photo's from the photostream in iphoto to events, are they ALWAYS saved on my mac drive even there there is a 1000/30 day limit in photostream?
I have tried moving from mobile me to icloud but do not get the new icons like photostream in my icloud window just the original mobile me icons?
When I connect my iPhone 4 to my MacBook Pro only about half of the photos on my photo stream sync into iPhoto. How do I get the photos that don't sync to sync onto the computer?


The campaign also features an original song with energy-filled music and inspiring lyrics that reflect the beats of contemporary African electronic club music. Produced by Blinky Bill, the song has popular sounds and rhythms that are currently dominating the radio, blasting out of taxicabs and on the dancefloors across the continent. Music is a unifying language not just across Africa, but around the world, and the song does away with cultural clichés, instead celebrating the vibrant energy of contemporary Africa.


text:
Arizona Courts Self-Service – Legal Forms
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text:
Ind. adviser fired after yearbook's pregnancy section sparks controversy
May 26, 2010 September 5, 2018 Josh Moore
INDIANA — The C. A. Beard Memorial School Corporationofficially fired the Knightstown High School yearbook and newspaper adviser lastweek following controversy over including a section in the yearbook aboutpregnant students.
But Principal Scott Ritchie said the incident was only one of severalthings that led to the firing of K.C. Salter, who has been the yearbook adviserat Knightstown for nine years.
Ritchie said that a pregnant student was upset that a yearbook staff memberhad come into a classroom to take a picture of her. The staffer also told thepregnant student that she needed the name of the baby's father so shecould get a picture of him too, he said.
But Salter said the situation, which happened about three months ago, hasbeen exaggerated and the staff was not trying to embarrass anyone or match upmothers and fathers. He said nothing specific was planned yet and the reporterwas only trying to find other students to talk to and photograph.
"I would never go that direction," he said. "That wouldbe irresponsible of an adviser to even suggest that."
Yearbook staffers had the idea to cover the school's pregnancyproblem and had only started brainstorming ideas, Salter said. He tookresponsibility for the staffer's actions.
"I thought I was clear with the student, and she was a littleoverzealous," he said.
Ritchie said he was fine with the students covering the school's teenpregnancy problem, but was concerned about how the staff member demonstrated alack of training in handling the situation.
"They did a pregnancy piece in our newspaper earlier thisyear," he said. "It was very well done and wellwritten."
The yearbook incident was not the only reason Salter was fired, Ritchiesaid. He cited poor performance with classroom management, discipline andquality, but declined to comment further publicly. Declining quality of theyearbook and newspaper was part of that, he said.
"This is one small piece of the puzzle that got us here,"Ritchie said, referring to the yearbook controversy. "If this is all wehad, I don't know if we would be to this point right now."
Salter acknowledged that the quality of the yearbook and newspaper was notup to what the administration wanted. But he said after Ritchie asked him torestart the newspaper two years ago, he felt he had inadequate time andresources to do both.
The district has started looking for a replacement for next year but hasallowed Salter to stay for the rest of the school year, Ritchie said.
Salter said he plans to challenge his firing because he does not think thedistrict followed proper procedures leading up to last week'sdecision.
Tagged Indiana, Knightstown High School


text:
AFP photographer wins Arab Journalism Award
DUBAI - AFP photographer Ahmad Gharabli (pictured, right) on Wednesday took home first prize at the Arab Journalism Awards in Dubai for his work documenting protests in Jerusalem.
Gharabli, who has been with Agence France-Presse since 2006, won first place in the photojournalism category at the Arab Media Forum for a series of images documenting Palestinian demonstrations in east Jerusalem.
Among his work is a photo of four women huddled in fear against a shuttered storefront as an Israeli policeman on horseback dispersed a December 9, 2017 protest.
Gharabli, 37, is himself a Palestinian from annexed east Jerusalem, which was seized by Israel in 1967 in a move never recognized by the international community.
The annual Arab Media Forum, held Tuesday and Wednesday in Dubai, was dominated this year by the global fight against "fake news."
The forum also featured a talk by AFP global editor-in-chief Phil Chetwynd, who addressed the growing impact of visuals on the news in the digital era. - AFP
The Express Tribune, April 3, 2019


text:
Q: Determine the present value of a perpetual annuity I want to determine the present value of a perpetual annuity, which will incur an interest payment of € 1 at the end of each year;
A calculative interest rate $r$ is assumed.
We are at the time $t = 0$, the first payout is in $t = 1$.
$$$$
Could you maybe give me a hint about how we could calculate it?
Is it maybe  $1+r\cdot t$ ?

A: I'll assume that you are the owner of the annuity, and that you receive the payment of 1 € at the end of each year. The issuer of the annuity will have to pay this amount. We assume that the interest rate is fixed at $r$, and we use this value for all calculations; this is the meaning of the term calculative interest rate. (In real life, interest rates will go up and down, which introduce uncertainty into the calculations.)
The present value of the first payment is $1\over 1+r$, since that is what the issuer will have to set aside today in order to make the payment at time $t=1$. The present value of the second payment is $1\over (1+r)^2$, which the issuer sets aside today for the payment of 1 € at time $t=2$. Continuing in the same minner, the present value of the perpetual annuity is the sum of the infinite geometric series
$${1\over 1+r}+{1\over (1+r)^2}+\dots={1\over 1+r}{1\over 1-{1\over 1+r}}={1\over r}$$
If you were to receive $A$ € each year, all terms above are multiplied by $A$, and the present value becomes $A\over r$, in agreement with the formula in Wikipedia.

A: Let denote the annuity denote as $a$ and the interest rate as $r$. If the annuity incur an interest of 1€ per year  then $a\cdot r=1$.
You receive an amount of a€ for $n$  periods. The present value of that payments is
$PV=\frac{a}{q^n}\cdot \sum_{i=0}^{n-1} q^i=\frac{a}{q^n}\cdot \frac{1-q^n}{1-q} \quad$ with $q=1+r$
$=\frac{a}{q^n}\cdot \frac{1}{1-q}-\frac{a}{q^n}\cdot \frac{q^n}{1-q} =\frac{a}{q^n}\cdot \frac{1}{1-q}- \frac{a}{1-q}= \frac{a}{q^n}\cdot \frac{1}{1-q}+ \frac{a}{q-1}$
Now  $n$ goes to infinity.
$$\lim_{n\to \infty } \frac{a}{q^n}\cdot \frac{1}{1-q}+\lim_{n\to \infty }\frac{a}{q-1} $$
$=0+\frac{a}{q-1}$
with $q=1+r$ we get
$PV=\frac{a}{1+r-1}=\frac{a}r$
With $a\cdot r=1$
$PV=a^2$ or $PV=\frac1{r^2}$

redpajama_set_name: RedPajamaStackExchange


Download the Latest Version of GHD Sports App for your Android device from this page and follow the instructions to install it on your android device from the guide "How To Install GHD Sports APK on Android". Have a great time watching all your favourite sports live at free of cost from now.
Please find out all available versions provided below.
Note: We have withdrawn the links to the app and we don't encourage you download that; instead, you can use the legit sources to watch live sports and games with HD Audio & Video Quality.
If you would like to install the Apk file downloaded above on various devices such as Android, Windows/Mac, FireStick, iPhone, Android TV Box; check out the tutorials provided below.
Please refer the guides provided above if you don't know how to install the Apk on your devices.


text:
Polyrhachis storki is een mierensoort uit de onderfamilie van de schubmieren (Formicinae). De wetenschappelijke naam van de soort is voor het eerst geldig gepubliceerd in 2008 door Kohout.

Polyrhachis


text:
Q: Google improved search box within the search results not working
I follow Google's tutorial for improved search box within the search results just like above screenshot.
I added this code in my front sitepage:
<script type="application/ld+json">
{
   "@context": "http://schema.org",
   "@type": "WebSite",
   "url": "https://www.xxx.com/",
   "potentialAction": {
   "@type": "SearchAction",
      "target": "https://www.xxx.com/search/site/{keys}",
      "query-input": "required name=keys"
    }
 }

 </script>

Am I doing something wrong? My site uses Drupal 7.

A: Looks correct (assuming that /search/site/strawberry successfully searches for "strawberry").
Note that Google is not displaying the Sitelinks Search Box for all sites/queries:

Search box not displaying? The sitelinks search box appears only for navigational queries and when relevant for users. Google algorithms use a variety of factors to determine when the box appears, including the information on the site and different types of navigational queries from Search users.

Edit: 2017-05-09 Updated Sitelinks Search Box Information and URL


text:
Qld government slammed over deforestation
30 December 2021, 1:51 am ·2-min read
Conservation groups have criticised the Queensland government after it was revealed almost 690,000 hectares of land was cleared during a 12-month period.
The government said the 2018-19 Statewide Landcover and Trees Study released on Thursday showed less than one per cent of state land was cleared in endangered areas.
Resources Minister Scott Stewart said Australia-first, higher resolution technology helped identify land clearing more accurately in the latest report.
But conservation groups said it indicated land clearing had been significantly under reported "for years" and the state was likely to be releasing more emissions from deforestation than reported.
The 2018-19 report revealed 680,688 ha had been cleared compared to 356,000 ha in 2016-17 and 392,000 ha in 2017-18.
WWF-Australia said the findings indicate Queensland is a "carbon bomb" set to destroy the national 2050 climate change net zero target and the state's own plan to reduce emissions by 30 per cent by 2030.
"More forest and woodland is destroyed in Queensland than in any other state in Australia," WWF-Australia's Stuart Blanch said.
"Eastern Australia was identified as a global deforestation hotspot by WWF-International last January, and is the only developed nation on that list.
"This cannot go on."
WWF-Australia has urged the Queensland government to embrace reforestation, saying it would benefit the ailing koala population, reduce water pollution to the Great Barrier Reef, significantly cut climate pollution and create a multi-billion-dollar carbon farming sector.
The Queensland Conservation Council said the latest findings were "heartbreaking".
"This data reveals that deforestation in Queensland is still out of control and is a serious risk to vulnerable wildlife and turbo-charging carbon release and climate change," council director Dave Copeman said.
Deputy Premier Steven Miles said on Thursday a group of scientific experts would be assembled in early 2022 to better understand the study results and find ways to help avoid clearing or whether other measures were needed.
Conservations groups said the state government could start by closing land-clearing legal loopholes.
The Palaszczuk government passed a number of vegetation management law reforms in 2018 to curb soaring deforestation rates.
However, critics claim significant land clearing has continued because there were no measures to force landowners to amend maps that designated 'Category X' areas that were exempt from regulation.
The 2018-19 report revealed Category X areas accounted for about 70 per cent of the state's land clearing activity or 477,390 ha.
WWF-Australia said almost one-third of the land cleared in 2018-19 was in catchments flowing to the Great Barrier Reef, with 85 per cent in Category X areas.
They also urged the state government to work with beef farmers to find a tree-clearing solution with the report showing the industry accounted for 93 per cent of deforestation.
Qld records 18 virus deaths, 9974 cases
Another 18 people have died with COVID-19 in Queensland as the state records 9974 new virus cases amid news it is faring better under Omicron than modelling predicted.The latest deaths include one person in their 30s who was unvaccinated, and 12 people in aged care, Premier Annastacia Palaszczuk said on Friday.


You may have noticed a new tab on The Art of Striving called "Book of Mormon Book Club," and I wanted to introduce you to this exiting new project.
I started to do that and felt excited by what I was learning. I began to discover just how relevant the Book of Mormon is to life today, and I wanted to share that excitement and knowledge with others. So, I've started the Book of Mormon Book Club. It's an online book club that anyone can join.
You don't need to be a Latter-day Saint to read the Book of Mormon. I am positive anyone who reads it will find inspired words of wisdom and an increased faith in God. Here's a video introduction to the club.
Subscribe to the YouTube channel and like the page on Instagram for weekly reading assignments and questions to guide your reading. Check out www.bookofmormonbookclub.wordpress.com for guides and worksheets for further study.
I'm thrilled to be starting this project and hope you'll read along. We're already into week 1!


Open-Vocabulary Semantic Parsing with both Distributional Statistics and Formal Knowledge.
Sequence labeling is the widely used method for CCG supertagging task where a supertag (lexical category) is assigned to each word in an input sentence. In CCG.
A Dynamic Window Neural Network for CCG Supertagging.
Information Extraction for the Seed Development Regulatory Networks of Arabidopsis Thaliana.


BIS Scientist B Recruitment 2019 Notification: Online application form has invited by the Bureau of Indian Standards to fill 109 Scientist Posts. Lot of candidates that complete Bachelor Degree in engineering or Technology can apply application form before last date of it. According to BIS Scientist Jobs 2019 Notification the process to make application form start on 16 March 2018 and candidates can access online portal till 2 April 2018. Before registration application form candidates must ensure their education qualification and age limitation with help Bureau of Indian Standards Scientist Vacancy Notification. The link to download notification is available at below. here are now we are providing you its related all and complete information.
Interested candidates those will go to apply application form need to complete Bachelor's Degree 111 Engineering with minimum 60% Marks. More information read notification.
Selection will be done through Interview / Written Examination. The interview will conduct after complete application form process.
Interested candidates must apply online application form before last date. The link to apply form is available below. They need to trough out all steps of application form before last date of it. At last they take a print out to future reference of it.
To upcoming latest information about the BIS Scientist B Jobs 2019 candidates can bookmark this online job portal we will provide all latest information at here.


Our Labrador Retriever Therapy or Service Dog ID Tag is just the way to honor the training your dog has completed. It takes a special dog, and that's exactly what you have. This ID tag has a brass top that is engraved with the outline of a Labrador, your dog's name and you choose whether you want Therapy Dog or Service Dog hand stamped with a paw print accent. To make sure someone can reach you if your special dog is lost, have your telephone number engraved on the back. If your dog's name is longer than 6 letters it will be engraved on the back. This tag can also be used for a keychain fob or luggage ID tag.
Metals used: nickel silver back, brass top with engraved with a Labrador and hand stamped with a paw print and the words "Therapy Dog" or "Service Dog".


Start seeds and root cuttings right with OASIS Horticubes! Because cubes are pH-neutral and extremely porous, they are multi-purpose and work especially well in hydroponic systems. OASIS Horticubes are designed to drain off excess water from the base of the germinating seed or cutting while maintaining a proper air to water balance. Includes 2 sheets of 50 cubes.


text:
Mackie's of Scotland
Aberdeenshire's Mackie's turn sunshine into ice cream
Imagine if you could turn sunshine into ice cream. This vision has become a reality for one family business in Aberdeenshire that has ambitions to power its farm, dairy, chocolate and ice cream factory entirely by renewable energy.
Mackie's of Scotland has been producing ice cream from its herd of 300 Holstein/Friesian and Swedish Red cattle for over 30 years. But the company has bigger ambitions, with a mission to establish a Scottish global brand from the greenest company in Britain.
To make this happen, the family installed the farm's first commercial wind turbine in 2005 and in 2015 built the largest solar farm in Scotland at the time, made up of almost 7,000 panels stretching over ten acres. This, along with three biomass boilers that provide heat to the company's headquarters and eight other properties, means the mix of wind, solar and biomass provide 70% of the farm's energy.
Last year Joe Lane, director of production for the business, moved to Aberdeenshire with his family to help the company further its green-powered ambitions. Originally from Nottingham, Joe approached Mackie's with a plan to install a low-carbon refrigeration system run on ammonia – a natural refrigerant gas that poses no threat to the environment. Company managing director, Mac Mackie, then brought him on board to make the £4 million investment a reality.
"I have been very invested in the project, so when Mackie's were looking for a new Production Director, Mac asked me if we would consider relocating," said Joe. "The ammonia refrigeration system, coupled with a biomass driven absorption chiller, will be the first of its kind in Scotland."
Some may be surprised to learn that a solar farm can thrive in the north of Scotland, but others have since followed in Mackie's footsteps, with larger solar farms having been built in Perthshire and another planned even further north in Moray.
Joe explained: "Aberdeenshire gets favourable sunshine hours compared to many parts of Scotland. The generation capacity based on sunshine hours in this area provided an acceptable return on investment for Mackie's and contributes towards a key objective within Mackie's mission statement."
Meanwhile, the new refrigeration system is a key stepping-stone for the company's plans to be 100% powered by renewable energy. It will enable Mackie's to significantly reduce the amount of electricity it consumes, targeting an ambitious 80% reduction in CO2 emissions. The project has also attracted significant government funding to promote it as a demonstrator of innovative, low carbon technology for other Scottish businesses.
"Mackie's has always been bold when it comes to investing in renewable and low carbon technologies," said Joe. "This is something I find very exciting."
More Global City case studies
Brewing up a storm
Novabiotics
Bio-therapeutics at Foresterhill
ROVOP


Streaming is the future of music consumption.
In Nielsen and Billboard's sales numbers for 2013, streaming music increased 32 percent over the previous year, to 118.1-billion track streams. Overall music sales dropped 6.3 percent to about 1.5-billion tracks, albums, and videos. Digital music sales (downloads) dropped too, by 6 percent, about the same rate.
The Recording Industry Association of America recently announced that revenue from streaming-music services overtook that from the sale of physical CDs, and came in just a hair behind total physical sales. The RIAA also said that streaming now accounts for 27 per cent of recording industry revenues in the first half of 2014, versus 20 per cent the year prior.
About 35 percent of the revenues of my record company, Nettwerk Records, already come from streaming, and that amount is only going to grow in the coming years.
When music is streamed online, songwriters in North America are currently being vastly underpaid for the music they create, some thousandth fraction of a penny for each streaming play (though, as SOCAN CEO Eric Baptiste pointed out in his last SOCAN blog, there are reasons for this).The same is generally true for the artists, and the non-major record companies whose music is being streamed, which is why streaming is not yet offsetting the decline in physical sales and downloads in North America.
The solution to this problem is for record companies to seek a percentage of the revenue earned by the streaming companies, rather than a penny rate "per play" (or in this case, "per stream"). The solution must also create equitable deals between the labels and their artists to ensure that the artists are fairly compensated after such negotiations.
There's a great deal of generational resistance to this idea. Past generations are strongly invested in the attitude that rates of remuneration for recordings have to be set by a governmental regulatory body. But in the online world, where borders are becoming more and more meaningless, where a song streams to one person at a time rather being played to hundreds of thousands of people via a spin on radio, and where streaming companies' revenues are dwarfed by many orders of magnitude when compared with traditional media such as TV and radio, the only practical way forward is to abandon penny-rate regulations and negotiate percentage deals directly with the streaming companies. In addition to payment for access to their music, major labels are already obtaining equity in music streaming companies.
This approach can work. In fact, it already has. Nordic European countries are seeing growth from streaming music, and their artists are earning a significant portion of their living from it. The Norwegian recording industry reported that streaming revenue was up 66 percent in the first half of 2013. Streaming revenue accounted for two-thirds of total music revenues in Norway. It's been a similar story in Sweden, Finland and Denmark. Sweden's music industry is now back to double-digit growth, even though about 90 percent of the music consumed there occurs via streaming.
By comparison, if the penny-rate mentality doesn't disappear sooner rather than later, the North American record industry will continue to shrink annually at a rate of five to six percent. In fact, one of the reasons Nettwerk has been able to prosper in the face of this continuing decline is that 90 percent of our income comes from outside of Canada.
The writing is on the wall. The old way needs to go. The record industry has got to get moving, and moving fast, to adapt to the new reality of music streaming.
Views expressed in this and all posts on this blog are not necessarily those of SOCAN.


text:
Q: Trigonometric Interpolation returns NaN I'm a musician, who's new to programming. I use JavaScript inside Max Msp (hence the bang() and post() functions) to create a trigonometric interpolation, interpolating between given equidistant points (for testing, only values of sine from [0, 2π) and returning values from the same points). When I run the code, it returns NaN, except for x = 0, as my tau() function returns only 1 in this special case. Could it be, that it has something to do with summing Math.sin results?

var f = new Array(9);
var TWO_PI = 2*Math.PI;

bang();

function bang() {
    for(var i = 0; i < f.length; i++) {
    f[i] = Math.sin(i/f.length*TWO_PI);
    //post("f[" + i + "]: " + Math.round(f[i]*1000)/1000 + "\n");
    }

    var points = new Array(f.length);
    for(var i = 0; i < points.length; i++) {
        var idx = i/points.length*TWO_PI;
        points[i] = [i, p(idx)];
    //post("p[" + points[i][0] + "]: " + Math.round(points[i][1]*1000)/1000 + "\n");
    }

    console.log("p(2): " + p(2/points.length*TWO_PI) + "\n");
}

function p(x) {
  var result = 0;
  for(var k = 0; k < f.length; k++) {
    result += f[k]*tau(k, x);
  }
  return result;
}

function tau(k, x) {
    var dividend = sinc(1/2*f.length*(x-k/f.length*TWO_PI));
    var divisor = sinc(1/2*(x-k/f.length*TWO_PI));
    var result = dividend/divisor;
    if(f.length%2 == 0) result *= Math.cos(1/2*(x-k/f.length*TWO_PI));

    if(x == 0) return 1;
    return result;
}

function sinc(x) {
    return Math.sin(x)/x;
}

A: In your tau function, if x equals k / f.length * TWO_PI (which it will since x is multiples of 1 / points.length * TWO_PI) your sinc function divides by 0, making divisor equal to NaN, which then propagates.

A: You have to be a bit careful in implementing sinc to avoid dividing by 0. One way is to say that if x is small enough we can replace sin(x) by the first few terms of its taylor series, and all the terms are divisible by x.
I don't know javascript but here is the function in C in case it is of use
#define SINC_EPS (1e-6)
// for small x,
// missing sinc terms start with pow(x,4)/120, and value close to 1
// so the error too small to be seen in a double
double  sinc( double x)
{       if ( fabs(x) < SINC_EPS)
        { return 1.0 - x*x/6.0;
        }
        else
        { return sin(x)/x;
        }
}