text:
using AeccApp.Core.Models;
using System.Collections.ObjectModel;
using System.Windows.Input;
using Xamarin.Forms;
using System.Threading.Tasks;
using AeccApp.Core.Services;
using AeccApp.Core.Extensions;
using System.Linq;

namespace AeccApp.Core.ViewModels
{
    public class HomeAddressesListViewModel : ViewModelBase
    {
        public IAddressesDataService AddressesDataService { get; } = ServiceLocator.AddressesDataService;

        #region Activate & Deactive Methods
        public HomeAddressesListViewModel()
        {
            HomeAddressesList = new ObservableCollection<AddressModel>();
        }

        public override Task ActivateAsync()
        {
            return ExecuteOperationAsync(async () =>
            {
                var homeAddresses = await AddressesDataService.GetListAsync();
                HomeAddressesList.SyncExact(homeAddresses.Where(x=> !x.IsHospitalAddress).ToList());
                HomeAddressesIsEmpty = !HomeAddressesList.Any();
            });
        }
        #endregion

        #region Properties
        public ObservableCollection<AddressModel> HomeAddressesList { get; private set; }

        private bool _homeAddressesIsEmpty;
        public bool HomeAddressesIsEmpty
        {
            get { return _homeAddressesIsEmpty; }
            set { Set(ref _homeAddressesIsEmpty, value); }
        }
        #endregion

        #region Commands

        private Command _chooseAddressCommand;
        public ICommand ChooseAddressCommand
        {
            get
            {
                return _chooseAddressCommand ??
                    (_chooseAddressCommand = new Command(OnChooseAddress, o => !IsBusy));
            }
        }

        /// <summary>
        ///
        /// </summary>
        /// <param name="obj">obj contains the HomeAddressList item tapped</param>
        private async void OnChooseAddress(object obj)
        {
            var selectedAddress = obj as AddressModel;
            await NavigationService.NavigateToAsync<HomeRequestChooseTypeViewModel>(selectedAddress);
        }

        private Command _newHomeAddressCommand;
        public ICommand NewHomeAddressCommand
        {
            get
            {
                return _newHomeAddressCommand ??
                    (_newHomeAddressCommand = new Command(OnNewHomeAddressCommand, o => !IsBusy));
            }
        }

        async void OnNewHomeAddressCommand(object obj)
        {
            await NavigationService.NavigateToAsync<NewHomeAddressViewModel>();
        }

        #endregion
    }
}

redpajama_set_name: RedPajamaGithub


Good quality vanilla pods have a delicately pure aroma that's quite different from the artificial vanilla used in many products. These simple ideas are a great way to appreciate the difference.
Vanilla coffee: Leave a vanilla pod exposed to the air until it goes hard. Break off a small piece and add to your coffee beans in the grinder.
Vanilla sugar: Leave a vanilla pod exposed to the air until it goes hard. Grind in a coffee grinder and add to your sugar. Use to flavour tea, coffee, cereal and desserts. You can also keep a few vanilla pods in a jar of sugar and use for baking etc.


Reebok relaunches their basketball department this season with retro-inspired new performance footwear, including models like the Q96. Taking obvious inspiration for the classic Question, Allen Iverson's first signature shoe, the Q96 will arrive in two familiar colorways of white/red and white/blue. The shoe features a lock-down lacing system, DMX foam cushioning and a lighweight and breathable synthetic upper.
Look for the Q96 on the feet of must-watch rookie Nerlens Noel as the NBA season begins, and pick them up in both colorways on November 1st at select Reebok retailers including Private Inc.


Detective Cluespot was putting together the suspect's profile. It was known that the suspect had two children and that one of them was a boy. What is the probability that the suspect's other child is also a boy?
It's not what you may think!
The obvious answer is one half but consider the following.
The first child is a boy and the second child is also a boy.
The first child is a boy and the second child is a girl.
The first child is a girl and the second child is a boy.
Of these three possibilities only one of them has the other child a boy. So the answer is one third.
The answer can also be found by using the conditional probability formula.


text:
Mischief Theatre
REVIEW: The Comedy About A Bank Robbery, Criterion Theatre ✭✭✭✭✭
Matthew Lunn 25th April 2016 25th April 2016 Reviews, West End
The Comedy About A Bank Robbery is uproariously funny. It is irreverent and energetic, with a versatile and imaginative set that lends itself brilliantly to unapologetic silliness. Perhaps most importantly, the script is not only very clever, but its characters are extremely consistent. They are desperate to fulfil their best laid plans, so when things go wrong, you really feel for them. Then things keep getting worse, and worse. And the belly laughs pour forth.
REVIEW: The Play That Goes Wrong, Duchess Theatre ✭✭✭✭
Douglas Mayo 25th February 2016 11th April 2015 Reviews, West End
It's all downhill from there. The drama begins and quickly it all goes to pot. Lines are forgotten, the acting is terrible, and the efforts of all of the actors on stage are at odds with each other resulting in a calamitous mess. But it's hilarious.

redpajama_set_name: RedPajamaCommonCrawl


text:
OpenBU
Dissertations and Theses (pre-1964)
The thyroid gland of the Atlantic Salmon
Hoar, William Stewart
The anlage of the thyroid gland of the Atlantic salmon, Salmo salar L., appears during the eleventh week or incubation when the embryo is approximately 8.5 mm. long. The pharyngeal region is partially differentiated at this time. Five gill arches are mapped out as lateral concentrations of mesoderm, the epithelial pouches and grooves, with the exception of the first true gill cleft, being solid between. There is no indication of cartilage formntion, nor have the copulae of the arches appeared ventral to the solid pharynx. Two blood vessels, the hyoids, extend cranially from the S-shaped tubular heart into the hyoid arch, but the aortic arches proper are as yet undeveloped. The thyroid anlage arises as a solid knob-like proliferation from the entoderm of the mid-ventral floor of the pharynx at the caudal margin of the hyomandibular junction. The nuclei of the cells soon become arranged around the periphery of the mass, leaving a clear cytoplasmic area within. No evidence of a lumen, however, is seen at any time. The anlage increases in size and its unattached extremity comes to lie in the bifurcation of the truncus arteriosus. The development of the basihyoid cartilage and the rapid cranial growth of the lower jaw during the thirteenth and fourteenth week (9 mm. embryos) tend to sever the anlage from the floor of the pharynx. Since the thyroid, heart and associated vessels do not grow forward with the jaw their position becomes relatively more caudal. The result of this positional change is that, by the end of the seventeenth week, the thyroid although still in the bifurcation of the ventral aorta is entirely caudal to the basihyoid complex. At this time the cranial portion of the anlage lies dorsal and rostral to the bifurcation, while the caudal and lateral portions lie beneath the border of the hyoid vessels at their point of origin. When the embryo is between 10 and 11 mm. long the cells of the thyroid anlage become arranged into solid spherules in which colloidal material collects and the structure shows evidence of breaking up and scattering. At this same time the ventral aorta is developing into an elongated vessel from a sac-like expansion of the cranial end of the heart. The actively proliferating thyroid tissue simply spreads out around this elongating vessel in whatever space is available. There is no evidence of an active migration of the follicles. Tje process of primary follicle formation is seen to involve a proliferation of cells, the rearrangement of these into solid spherules, cavity formation within the spherules and the collection ot chromophobic and finally chromophilic material within the cavities. Secondary follicles arise from the primary follicles through a process of budding. By the time the embryo is 11 mm. long three more or less distinct, but not entirely separate masses, of the thyroid tissue are evident. These consist of areas of undifferentiated thyroid tissu together with primary follicles containing typical colloid. Two of these masses lie dorsal and one lies ventral to the aorta. The anterior dorsal mass is found at the cranial border ot the ventral aorta and the posterior dorsal mass at the level of the second aortic arch. The differentiating thyroid tissue seems to have been forced into these positions by the growth of surrounding structures. The same general arrangement of the thyroid is evident in the construction or the glands of salmon of all ages. Although the proliferation of thyroid tissue continues during the entire period of growth the gland has attained its final form by the time the fish is 28 mm. long. The bulk of the oxygen increases but the same general boundaries are always maintained after this time. The thyroid of the adult salmon is a diffuse organ consisting of independent follicles scattered in the loose connective tissue of the throat region. Only in the very large salmon do the acini become so closely related as to form a compact and nodular gland. The thyroid tissue extends form the caudal border of the first basibranchial to a short distance behind the common origin of the third and fourth aortic arches. It is not normally found cranial to the hyoid complex, but in a few cases anomalies occur in the region of the primary anlage, i.e. the hyomandibular junction. The largest mass of the adult gland is found around the second aortic arches. There is little thyroid tissue lateral to the ventral aorta, and the number of follicles ventral to this blood vessel is always less than the number dorsal to it. The characteristics of the thyroid acini do not differ from those of other vertebrates, In salmon the follicles are supported by a fatty connective tissue of a reticular nature. The adipose cells have a peculiar vacuolated appearance when treated with osmic acid. Elastic fibers and smooth muscle cells identified by some investigators could not be found. Lymphatics seem to play a predominant role in the vascularization of the salmon thryoid. Although the hypobrachial artery was studied, branches from this to the thyroid tissue could not be found, nor could the thyroid veins be identified. On the other hand a complicated system of lymphatics forms a large sinus about the thyroid tissue. This sinus consists of a large dorsal channel and a smaller ventral vessel with many lateral connections between the two. The system communicates with the inferior jugular veins in the cranial direction and drains into the pericardial lymph sinuses caudally. Intimate contact is formed between the epithelium of the follicles and the endothelium of the lymphatics. In the more massive glands lymph capillaries extend from the main sinus between the acini. Although it can be said that blood capillaries are unimportant in the physiology of the salmon thyroid, it seems evident that the lymphatics play an important role in the removal of the colloid . Histophysiological studies have shown a correlation between the functional condition of the thyroid gland and the activities of the Atlantic salmon. Seasonal changes in thyroid activity are very definite. Like all cold blooded animals the salmon shows an increase in thyroid activity during the spring and summer, with a marked decline in the fall and winter. As evidence of this there is a complete withdrawal of colloid material from the follicles during the early part of June. This coincides with the period of most rapid growth of the fish. Throughout the summer a lightly acidophilic colloid with numerous chromophobic peripheral vacuoles indicates a mild degree of activity. Dense acidophilic colloid within the follicles during the fall and winter is characteristic of a passive gland. However, seasonal activity of the salmon thyroid is not great enough to cause a pronounced increase in the height of the epithelium or in the size of the follicle. In general it is found that the glands of the young salmon are more active than those of the older fish. An active hyperplasia of the thyroid occurs during the smolt stage, that is when the young fresh water fish undergoes changes preparatory to its migration to the sea. The changes taking place in the salmon at this time seem to be of sufficient magnitude to warrant the classing of this period as a "metamorphosis" and comparing it with metamorphosis as seen in other forms. Different degrees of thyroid activity are found in the smolt, but the follicles always show a change in the epithelium from cuboidal to columnar, together with an increase in the size of the follicle and in the number of follicles. The colloidal material becomes much less acidophilic and may be entirely withdrawn from the acini and appear in the neighboring lymphatics. This activity occurs in the early spring and is followed by a partial involution of the gland during the summer of the same year. Involution becomes complete as winter approaches and the thyroid assumes the appearance of a gland of "colloid goiter". In other words the thyroids of the large sea salmon consist of very large macroscopic follicles associated with numerous small microscopic ones. This condition is seen to be the result of the collection of colloid in the hyperplastic follicles of the smolt. The gland has become so enlarged in these adult salmon that it often forces the neighboring connective tissue into the semblance of a capsule. The male salmon parr is precocious in its sexual development. Significant changes in the structure of the thyroid gland are not found during the process of sexual maturation either in the parr or in the large adult fish.
Thesis (Ph.D.)--Boston University
Based on investigation of the BU Libraries' staff, this work is free of known copyright restrictions
Dissertations and Theses (pre-1964) [13049]
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Neo Fuji: "state of the fuji"
Balls to Emax. They terminated my account for reasons I won't go into (but suffice to say they thought I was doing something I wasn't actually doing), which I was not expecting. And now they won't answer my emails. So, the last backup I had locally was from mid-November, and I've lost a good chunk of stuff that I was working on but hadn't made public yet. Arse. But, yeah, once again I've moved hosts and everything should be working just fine. New stuff is still forthcoming, just later than I planned. I will continue to keep on top of the 505 and Simple lists, at least, although they may be out of date for a while.


text:
Сренг (давньоірл. Sreng) — ірландський герой, один із воїнів клану Фір Болг, посланець до Племен богині Дану. При зустрічі з їхнім посланцем Бресом він зауважив, що в супротивника значно досконаліша і, більше того, магічна зброя. Саме тому Сренг попередив своїх одноплемінників із Фір Болг про те, що вони не зможуть здолати військо Племен богині Дану, проте його не послухали. Натомість найбільше Сренг прославився боєм проти Нуаду, що описаний у скелі «Битва при Маг Туїред», у якому він зумів розбити супротивнкиу щит, а також — відтяв йому руку. Через це Нуада назвавжди втратив право бути королем Племен богині Дану.

Джерела
 Monaghan P. The Encyclopedia of Celtic Mythology and Folklore. — New York: Facts on File, Inc., 2004. — 512 p.
 Rolleston T. W. Myths & legends of the Celtic race. — New York: T.Y. Crowell, 1910. — 457 p.
 Squire Ch. Celtic myth & legend, poetry & romance. — London: The Gresham Publishing Company, 1910. — 450 p.

ірландська міфологія
кельтська міфологія

redpajama_set_name: RedPajamaWikipedia


Rated 5 out of 5 by jacidances from Perfect top for me As usual, I love this top. It's cute and fits perfectly. Ulla Popken has great clothes!
Take Time Stripe Round Neck Sweatshirt is rated 5.0 out of 5 by 1.


L. Yang, Y. Orenstein, A. Jolma, Y. Yin, J. Taipale, R. Shamir and R. Rohs.
Molecular Systems Biology, 13, 910, DOI 10.15252/msb.20167238, 2017.
D. Amar, S. Izraeli and R. Shamir.
Journal of Computational Biology Vol 23 No 0. pp 1-11 (2016).
A. Nachshon, H. J. Abu-Toamih Atamni, R. Sheikh-Hamed, A. Dorman, R. Mott, J. C. Dohm, H. Lehrach, M. Sultan, R. Shamir, S. Sauer, H. Himmelbauer, F. A. Iraqi, I. Gat-Viks.
Frontiers in Genetics Vol 7, Article 172, doi: 10.3389/fgene.2016.00172 (2016).
D. Chen, Y. Orenstein, R. Golodnitsky, M. Pellach, D. Avrahami, C. Wachtel, A. Ovadia-Shochat, H. Shir-Shapira, A. Kedmi, T. Juven-Gershon, R. Shamir, D. Gerber.
Scientific Reports 6, 33351; doi: 10.1038/srep33351, 2016.
M. El-Kebir, B. Raphael, R. Shamir, R. Sharan, S. Zaccaria, M. Zehavi, R. Zeira.
Proceedings of WABI 2016, Aarhus, Denmark, August, 2016, LNCS, 9838 pp. 137-149 (2016).
Y. Orenstein, D. Pellow, G. Marcais, R. Shamir, C. Kingsford.
Proceedings of WABI 2016, Aarhus, Denmark, August, 2016, LNCS, 9838 pp. 257--268 (2016).
Briefings in Functional Genomics, doi: 10.1093/bfgp/elw030 (2016).
Proc. 27th Annual Symposium on Combinatorial Pattern Matching (CPM 2016), R. Grossi and M. Lewenstein (Editors), Dagstuhl, Germany, LIPIcs, vol. 54, pp. 16:1Ð16:13.
R. E. Bell, T. Golan, D. Sheinboim, H. Malcov, D. Amar, A. Salamon, T. Liron, S. Gelfman, Y. Gabet, R. Shamir and C. Levy.
Genome Research, 26 ( 5 ) pp. 601 - 611.
A. Maron-Katz, S. Vaisvaser, T. Lin, T. Hendler, R. Shamir.
Scientific Reports, 6, Article number: 21503, doi:10.1038/srep21503 (2016).
Evidence of TAF1 dysfunction in peripheral models of X-linked dystonia-parkinsonism.
A. Domingo, D. Amar, K. GrŸtz, L. Lee, R. Rosales, N. BrŸggemann, R. D. Jamora, E. Cutiongco dela-Paz, K. Lohmann, R. Shamir, C. Klein, A. Westenberger.
Cellular and Molecular Life Sciences , DOI 10.1007/s00018-016-2159-4 (2016).
Integrated microfluidic approach for quantitative high-throughput measurements of transcription factor binding affinities.
Nucl. Acids Res, doi: 10.1093/nar/gkv1327.
D. Amar, T. Hait, S. Izraeli and R. Shamir.
Nucleic Acids Research , 43 (16): 7779-7789, 2015.
Transcription , 6:3, 41-50, 2015.
A. Maron-Katz, D. Amar, E. Ben-Simon, T. Hendler, R. Shamir.
G. Marcais, D. Pellow, D. Bork, Y. Orenstein, R. Shamir, C. Kingsford.
R. Rozov, A. Kav Brown, D. Bogumil, E. Halperin, I. Mizrahi, R. Shamir.
Proceedings of CPM 2015, Ischia Island, Italy, June 2015. (F. Cicalese, E. Porat, U. Vaccaro, editors) LNCS , Vol 9133, pp 396-409, 2015.
R. Ohana, B. Weiman-Kelman, S. Raviv, E. Tamm, M. Pasmanik-Chor, A. Rinon, D. Netanely, R. Shamir, AS.Salomon, R. Ashery-Padan.
Development , Jun 10. doi: 10.1242/dev.121533, 2015.
D. Amar, D. Yekutieli, A. Maron-Katz, T. Hendler and R. Shamir.
Bioinformatics , 31 (12): i17-i26, ISMB/ECCB 2015, proceedings paper, doi: 10.1093/bioinformatics/btv228, 2015.
Evaluation and integration of functional annotation pipelines for newly sequenced organisms: the potato genome as a test case.
D. Amar, I. Frades, A. Danek, T. Goldberg , S.K. Sharma, P.E. Hedley, E. Proux-Wera, E. Andreasson, R. Shamir, O. Tzfadia, E. Alexandersson.
BMC Plant Biology , 5;14(1):329, 2014.
Drosophila TRF2 is a preferential core promoter regulator.
Genes and Development, 28 (19) pp. 2163 - 2174, 2014.
Fast lossless compression via cascading Bloom filters.
BMC Bioinformatics, 15(Suppl 9):S7, 2014.
Examination of Exhaustive Cloning Attempts Reveals that C. elegans piRNAs, Transposons, and Repeat Sequences are Efficiently Cloned in Yeast, but not in Bacteria.
Frontiers in Genetics, 5:275, doi: 10.3389/fgene.2014.00275.
Nucleic Acids Research, doi: 10.1093/nar/gku667.
A comparative analysis of transcription factor binding models learned from PBM, HT-SELEX and ChIP data.
Nucleic Acids Research doi: 10.1093/nar/gku117, 2014.
Constructing module maps for integrated analysis of heterogeneous biological networks.
Nucleic Acids Research doi:10.1093/nar/gku102, 2014.
Environmental stresses disrupt telomere length homeostasis.
PLoS Genetics,9(9):e1003721. doi: 10.1371/journal.pgen.1003721. Epub 2013.
Design of shortest double-stranded DNA sequences covering all k-mers with applications to protein-binding microarrays and synthetic enhancers.
Bioinformatics, Vol. 29 ISMB/ECCB, i71-i79, 2013.
RAP: Accurate and fast motif finding based on protein binding microarray data.
Journal of Computational Biology, Vol. 20, No. 5: 375-382 , 2013.
Systematic Inference of Highways of Horizontal Gene Transfer in Prokaryotes.
M.S. Bansal, G. Banay, T.J. Harlow, J.P. Gogarten, R. Shamir.
Bioinformatics, 29 ( 5 ) pp. 571 - 579, 2013.
Transcription Factor/microRNA Axis Blocks Melanoma Invasion Program by miR-211 Targeting NUAK1.
Journal of Investigative Dermatology, doi: 10.1038/jid.2013.340, 2013.
Dissection of Regulatory Networks that Are Altered in Disease via Differential Co-expression.
PLOS Computational Biology, Vol. 9, No. 3. e1002955, 2013.
Evaluation of methods for modeling transcription factor sequence specificity.
M.T. Weirauch, A. Cote, R. Norel, M. Annala, Y. Zhao, T.R. Riley, J. Saez-Rodriguez, T. Cokelaer, A. Vedenko, S. Talukder, DREAM5 Consortium (including Y. Orenstein, C. Linhart, R. Shamir), H.J. Bussemaker, Q.D. Morris, M.L. Bulyk, G. Stolovitzky & T.R. Hughes.
Parallel Profiling of the Transcriptome, Cistrome, and Epigenome in the Cellular Response to Ionizing Radiation.
S. Rashi-Elkeles, H.J. Warnatz, R. Elkon, A. Kupershtein, Y. Chobod, A. Paz, V. Amstislavskiy, M. Sultan, H. Safer, W. Nietfeld, H. Lehrach, R. Shamir, M.L. Yaspo and Y. Shiloh.
Assessment of algorithms for inferring positional weight matrix motifs of transcription factor binding sites using protein binding microarray data.
Y. Orenstein, C. Linhart , R. Shamir.
PLoS ONE, 7 (9) e46145, 2012.
Network-Induced Classification Kernels for Gene Expression Profile Analysis.
O. Lavi, G. Dror, and R. Shamir.
Journal of Computational Biology, 19(6), 694-709, 2012.
MGMR: leveraging RNA-Seq population data to optimize expression estimation.
R. Rozov, E. Halperin and R. Shamir.
BMC Bioinformatics, Proceedings of the Second Annual RECOMB Satellite Workshop on Massively Parallel Sequencing (RECOMB-seq 2012), 13(Suppl 6):S2, 2012.
A novel candidate cis-regulatory motif pair in the promoters of germline and oogenesis genes in C. elegans.
C. Linhart, Y. Halperin, A. Darom, S. Kidron, L. Broday and R. Shamir.
Constructing logical models of gene regulatory networks by integrating transcription factor-DNA interactions with expression data: an entropy based approach.
G. Karlebach and R. Shamir.
P. Pevzner and R. Shamir, editors .
Textbook. Cambridge University Press, UK, 2011.
Selected papers from the 2nd RECOMB satellite meeting on Bioinformatics Education (RECOMB-BE).
P. A. Pevzner, R. Shamir, editors.
A note on the fixed parameter tractability of the gene-duplication problem.
Bansal, M.S. and Shamir, R.
Integration of Transcriptomics, Proteomics, and MicroRNA Analyses Reveals Novel MicroRNA Regulation of Targets in the Mammalian Inner Ear.
T. Elkan-Miller, I. Ulitsky, R. Hertzano, A. Rudnicki, A. A. Dror, D. R. Lenz, R. Elkon, M. Irmler, J. Beckers, R. Shamir, K.B. Avraham.
L.C. Laurent, I.Ulitsky, I.Slavin, H. Tran, A. Schork, R. Morey, C. Lynch, J.V. Harness, S. Lee, M.J. Barrero, S. Ku, M. Martynova, R. Semechkin, V. Galat, J. Gottesfeld, J.C. Izpisua Belmonte, C. Murry, H. S. Keirstead, H.-S. Park, U. Schmidt, A.L. Laslett, F.-J. Muller, C. M. Nievergelt, R. Shamir and J. F. Loring.
Cell Stem Cell, doi: 10.1016/j.stem.2010.12.003,2011.
SPIKE: a database of highly curated human signaling pathways.
A. Paz, Z. Brownstein, Y. Ber, S. Bialik, E. David, D. Sagir, I. Ulitsky, R. Elkon, A. Kimchi, K. B. Avraham, Y. Shiloh and R. Shamir.
Nucleic Acids Research, Vol. 39, Database issue D793-D799, 2011.
Wisdom of crowds for robust gene network inference.
D. Marbach, J. C. Costello, R. Kueffner, N. Vega, R. J. Prill, D. M. Camacho, K. R. Allison, the DREAM5 Consortium (including G. Karlebach, R. Shamir), M. Kellis, J. J. Collins G. Stolovitzky.
The MORPH Algorithm: Ranking Candidate Genes for Membership in Arabidopsis and Tomato Pathways.
O. Tzfadia, D. Amar, L.M.T. Bradbury, E.T. Wurtzel, and R. Shamir.
The Plant Cell, 24(11):4389-406, 2012.
PrtT-Regulated Proteins Secreted by Aspergillus fumigatus Activate MAPK Signaling in Exposed A549 Lung Cells Leading to Necrotic Cell Death.
H. Sharon, D. Amar, E. Levdansky, G. Mircus, Y. Shadkchan, R. Shamir, N. Osherov.
Large-scale analysis of chromosomal aberrations in cancer karyotypes reveals two distinct paths to aneuploidy.
Ozery-Flato M, Linhart C, Trakhtenbrot L, Izraeli S, Shamir R.
Transcriptional and Proteomic Analysis of the Aspergillus fumigatus DprtT Protease-Deficient Mutant.
S.Hagag, P. Kubitschek-Barreira, G. W. P. Neves, D. Amar, W. Nierman, I. Shalit, R. Shamir, L. Lopes-Bezerra, N. Osherov.
PLoS ONE, Volume 7, Issue 4, e33604, 2012.
A Point Mutation in Translation Initiation Factor eIF2B Leads to Function- and Time-Specific Changes in Brain Gene Expression.
L. Marom, I. Ulitsky, Y. Cabilly, R. Shamir, O. Elroy-Stein.
PLoS ONE, 6, 269920, 2011.
An O(n3/2Ãlog(n)) algorithm for sorting by reciprocal translocations.
Transcriptional Modulation Induced By Ionizing Radiation: P53 Remains A Central Player.
S.Rashi-Elkeles, R. Elkona, S. Shavit, Y. Lerenthal, C. Linhart, A. Kupershtein, N. Amariglio, G. Rechavi, R. Shamir and Y. Shiloh.
Igor Ulitsky, Akshay Krishnamurthy, Richard M. Karp, Ron Shamir.
PLoS One , 5 (10) e13367 (2010).
Detecting Highways of Horizontal Gene Transfer.
Mukul S. Bansal, J. Peter Gogarten, and Ron Shamir.
8th Annual RECOMB Comparative Genomics Workshop (RECOMB-CG 2010), LNCS, 6398: 109-120 (2010).
PAKDD Data Mining Competition 2009: New Ways of Using Known Methods.
Chaim Linhart, Guy Harari, Sharon Abramovich and Altina Buchris.
Lecture Notes in Computer Science, Volume 5669/2010, 99-105, DOI: 10.1007/978-3-642-14640-4_7 (2010).
A Faster Algorithm for Simultaneous Alignment and Folding of RNA.
Ziv-Ukelson M, Gat-Viks I, Wexler Y, Shamir R.
I. Ulitsky, L. C. Laurent and R. Shamir.
Nucleic Acids Research, 38 (15): e160. pp 1-13 (2010).
A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking.
P.S. Aguilar, F. Fršhlich, M. Rehman, M. Shales, I. Ulitsky, A. Olivera-Couto, H. Braberg, R. Shamir, P. Walter, M. Mann, C.S. Ejsing, N.J. Krogan, T.C. Walther.
Nature Structural and Molecular Biology , Vol. 17 no. 7, pp 901-909(2010).
Bruckner, S., HŸffner, F., Karp, R.M., Shamir, R., Sharan, R.
Journal of Computational Biology , 17 (3), pp. 237-252 (2010).
Minimally perturbing a gene regulatory network to avoid a disease phenotype: the glioma network as a test case.
G. Karlebach, R. Shamir .
BMC Systems Biology , 4:15 doi:10.1186/1752-0509-4-15(2010).
Ras inhibits ER Stress in Human Cancer Cells with Amplified Myc.
S. Yaari-Stark, M. Shaked, Y. Nevo-Caspi, J. Jacob-Hircsh, R. Shamir, G. Rechavi, Y. Kloog.
International Journal of Cancer , Vol 126, 2268--2281 (2010).
Special issues dedicated to Michael Waterman on the occasion of his 67th birthday.
S. Istrail, P. Pevzner, R. Shamir. F. Sun, guest editors.
Communication in Information and Systems , Vol 9 3-4 (2009), Vol 10 1-2 (2010).
Different sets of QTLs influence fitness variation in yeast.
G. H. Romano, Y. Gurvich, O. Lavi, I. Ulitsky, R. Shamir, M. Kupiec.
Molecular Systems Biology 6:346, doi:10.1038/msb.2010.1, 2010 .
Expander: from expression microarrays to networks and functions.
I. Ulitsky, A. Maron-Katz, S. Shavit, D. Sagir, C. Linhart, R. Elkon, A. Tanay, R. Sharan, Y. Shiloh, R. Shamir.
Nature Protocols Vol 5, pp 303 - 322, 2010 .
Towards accurate imputation of quantitative genetic interactions.
I. Ulitsky, N.J. Krogan and R. Shamir.
Genome Biology , Volume 10:R140 2009 .
Assessing the Quality of Whole Genome Alignments in Bacteria.
Advances in Bioinformatics , Volume 2009, Article ID 749027, 8 pages doi:10.1155/2009/749027 (2009).
Sorting Cancer Karyotypes by Elementary Operations.
Journal of Computational Biology Vol. 16. no. 10, pp. 1445 - 1460, October 2009.
Computing Has Changed Biology - Biology Education Must Catch Up.
Education Forum in Science Vol. 325. no. 5940, pp. 541 - 542 (31 July 2009).
SlimPLS: a method for feature selection in gene expression-based disease classification.
M. Gutkin, G. Dror, R. Shamir.
PLoS One Vol. 4 No. 7 e6416 (2009) .
S. Bruckner, F. HŸffner, R. M. Karp, R. Shamir, R. Sharan.
Nucleic Acids Research doi: 10.1093/nar/gkp474.
Understanding gene sequence variation in the context of transcription regulation in yeast.
I. Gat-Viks, R. Meller, M. Kupiec, R. Shamir.
PLoS Genetics , Vol. 6 No. 1 e1000800 (2010).
A faster fixed-parameter approach to drawing binary tanglegrams.
S. Bocker, F. HŸffner, A. Truss, and M. Wahlstrom.
In Proceedings of the 4th International Workshop on Parameterized and Exact Computation,(IWPEC '09) Copenhagen,Denmark,September 2009 Lecture Notes in Computer Science, Springer.
O. Davidovich, G. Kimmel, E. Halperin, R. Shamir.
I. Ulitsky and R. Shamir.
Bioinformatics Vol. 25 no. 9 pages 1158-1164 (2009) .
C. Linhart and R. Shamir.
Journal of Computers and System Sciences , 75, 155--162 (2009).
Y. Halperin, C. Linhart, I. Ulitsky and R. Shamir.
Nucleic Acids Research 37:5, 1566-1579.
Information Processing Letters Volume 109, Number 5, p. 273-277 (2009).
M. Ozery-Flato and R. Shamir.
Proceedings of the 6th RECOMB Satellite Workshop on Comparative Genomics 2008, LNCS Vol. 5267 pp. 211-225 (2008).
M. Ziv-Ukelson, I. Gat-Viks, Y. Wexler and R. Shamir.
Regulatory networks define phenotypic classes of human stem cell lines.
F.J. Mueller, D. Kostka, L. Laurent, I. Ulitsky, R. Williams, C. Lu, M.S. Rao, R. Shamir, P.H. Schwartz, N.O. Schmidt and J.F. Loring.
Proc. RECOMB 2008, pp. 347--359, LNBI 4955, Springer, Berlin, (2008).
A. Levine, S. Kugathasan, A. Vito, V. Biank, E. Leshinsky-Silver, O. Davidovich, G. Kimmel, R. Shamir, P. Orazio, U. Broeckel, S. Cucchiara.
Risk factors for perianal Crohn's disease: the role of genotype, phenotype, and ethnicity.
R. M. Karp, M. Li, P. Pevzner, R. Shamir, Guest editors.
Nature Genetics, Vol. 39, No. 3 (2007) .
E. Halperin, G. Kimmel, R. Shamir.
BMC Genomics, 18:305, DOI 10.1186/s12864-017-3683-9, 2017.
Tired and misconnected: A breakdown of brain modularity following sleep deprivation.
E. Ben Simon, A. Maron-Katz, N. Lahav, R. Shamir and T. Hendler.
Human Brain Mapping, 38(6):3300-3314. doi: 10.1002/hbm.23596.
Bioinformatics, special issue of ISMB/ECCB 2017, Vol. 33, i110–i117 doi: 10.1093/bioinformatics/btx235, 2017.
Algorithms for Molecular Biology, 12(1), 13, 2017.
R. Rozov, G. Goldshlager, E. Halperin, R. Shamir.
D. Amar, R. Shamir, D. Yekutieli.
PLoS Computational Biology 13(8): e1005700, 2017.
T. A. Hait, D. Amar, R. Shamir and R. Elkon.
Journal of Computational Biology, DOI: 10.1089/cmb.2017.0060, 2017.
PLoS Computational Biology, 13(10): e1005777 (2017).
R. Shamir, C. Klein, D. Amar, E. J. Vollstedt, M. Bonin, M. Usenovic, Y. C. Wong, A. Maver, A. Troiano, S. Poths, H. Safer, J.-C. Corvol, S. Lesage, O. Lavi, G. Deuschl, G. Kuhlenbaeumer, H. Pawlack, I. Ulitsky, M. Kasten, O. Riess, A. Brice, B. Peterlin, D. Krainc.
BMC Bioinformatics, 18:488, 2017. Preliminary version: bioRxiv 152447; doi: https://doi.org/10.1101/152447, 2017.
G. Gilam, A. Maron-Katz, E. Kliper, T. Lin, E. Fruchter, R. Shamir, T. Hendler.
Frontiers in Behavioral Neuroscience, doi: 10.3389/fnbeh.2017.00252, 2017.
Bioinformatics, 34 (1) 147–154, https://doi.org/10.1093/bioinformatics/btx471, 2018.
D. Amar, A. Vizel, C. Levy & R. Shamir.
A. Zwaenepoel, T. Diels, D. Amar, T. Van Parys, R. Shamir, Y. Van de Peer and O. Tzfadia.
Front. Plant Sci., https://doi.org/10.3389/fpls.2018.0035, 2018.
T. A. Hait, D. Amar, R. Shamir, R. Elkon.
Genome Biology, 19:56, https://doi.org/10.1186/s13059-018-1432-2, 2018.
R. Zeira and R. Shamir.
Human Genomics, 12:30, https://doi.org/10.1186/s40246-018-0161-7, 2018.
Nucleic Acids Research, 46 (20) pp. 10546–-10562, (2018).
I. Nurick, R. Shamir and R. Elkon.
Z. Wang, H. Lou, R. Shamir, R. Jiang, T. Chen.
npj Biofilm and Microbiome} 4: 20, https://doi.org/10.1038/s41522-018-0065-2, 2018.
N. Rappoport and R. Shamir.
bioRxiv , doi: https://doi.org/10.1101/456723, 2018.


text:
Raves for Elaine May on Broadway
On Film / The Daily — Oct 29, 2018
Elaine May in Kenneth Lonergan's The Waverly Gallery; photograph by Brigitte Lacombe
Nearly sixty years after her debut on Broadway in the landmark improvisational comedy showcase An Evening with Mike Nichols and Elaine May, the director, screenwriter, script doctor, and whip-smart comedienne Elaine May returns to the Golden Theatre, in a revival of Kenneth Lonergan's The Waverly Gallery. She plays Gladys Green, a former lawyer who, now in her mideighties—May herself is eighty-six—runs the titular Greenwich Village gallery and struggles against rapidly encroaching dementia. As Ben Brantley puts it in the New York Times, for Gladys, "schmoozing and kibitzing have always been as essential as breathing," and she "operates on the principle that if she can just continue to talk, she can surely power through the thickening fog of her old age. That she has clearly already lost this battle makes her no less valiant."
The Waverly Gallery, which premiered off-Broadway in 2000 and became a finalist for the Pulitzer Prize for Drama the following year, is the third of Lonergan's six full-length plays to be revived on Broadway since 2014. In the new, Lila Neugebauer-directed production, which opened last Thursday and will run through January 27, Lucas Hedges (nominated for an Oscar for his performance in Lonergan's 2016 film Manchester by the Sea) addresses the audience from the edge of the stage as Daniel, Gladys's grandson and a "Lonergan stand-in," as Alexis Soloski notes in the Guardian, "played with slumped and diffident grace." Daniel describes his family as "liberal Upper West Side atheistic Jewish intellectuals," and for Peter Marks in the Washington Post, "Lonergan's ear for the crosscurrents of love and recrimination, of accusation and confession, is as fine as that of any American dramatist." Writing for the Wall Street Journal, Terry Teachout opts for a more succinct superlative, calling Lonergan simply "America's greatest living dramatist."
For Vulture's Sara Holdren, it's Joan Allen who gives "the show its heartbeat. As Gladys's daughter Ellen—an immensely capable, intelligent doctor whose impatience with her dwindling mother is mingled with, and concealing, fear and heartbreak she can't fully register—Allen is sneak-up-on-you stunning." The cast is rounded out by David Cromer, who, according to Brantley, is "impeccably tactless" as Ellen's second husband and Daniel's stepfather, and Michael Cera, "doing confident but clueless" as a young artist Gladys has decided to take under her wing.
But it's May who's scoring the majority of the raves in the first round of reviews. "Gladys's descent is quick and cruel, making May's portrayal of her mental drift, with a sweet and helpless but also determined intelligence, all the more wonderful," writes Vinson Cunningham in the New Yorker. "If acting is to human behavior what poetry is to language, May as Gladys in Waverly is somewhat like Marianne Moore—hilariously varied, brutally specific, funniest when oriented toward the grave." And New Yorker staff writer Nathan Heller adds via Twitter that he "can't think of anyone else who was a breath of fresh air sixty years ago and is a breath of fresh air today."
Vanity Fair's K. Austin Collins welcomes May's return to the stage, but argues that "her greatest contributions have been as a director—despite her painfully truncated career. In a moment rife with public awareness of Hollywood's fraught lack of women in the director's chair, May's directorial career still stands out as a cautionary tale." Her debut, A New Leaf (1971), which she wrote, directed, and starred in alongside Walter Matthau, "is one of that era's greatest comedies." The Heartbreak Kid, another cult favorite, this one starring Charles Grodin, Cybill Shepherd, and May's daughter, Jeannie Berlin, followed in 1972. And Collins insists that Mikey and Nicky (1976), with John Cassavetes and Peter Falk, "remains one of the best American gangster movies ever made." May's run-ins with the studios, "thanks at least in part to her zealous post-production process," kept her from directing another film until 1987, when Ishtar, "despite great preview screenings," flopped.
Over the years, though, Ishtar, starring Warren Beatty and Dustin Hoffman as miserably but hilariously untalented songwriters, has become one of the films maudit cinephiles most love to champion. Writing for Vogue, Marley Marius notes that, when someone suggested in 2011 that Ishtar was simply "ahead of its time, May's quippy response cut right to the root of her genius. 'No, that's impossible,' she said. 'Even with string theory.' It's classic May—charmingly self-deprecating and blisteringly smart, clever and quick without being nasty."


text:
Morgan Stanley Electronic Trading Executes First Direct Market Access Trade in India
First DMA Trade in India Completed on Friday, July 11
Morgan Stanley (NYSE:MS) today announced that it has executed the first Direct Market Access (DMA) trades in India through its electronic trading platform. The first customer DMA trade was completed on Friday, July 11, 2008.
"We are proud to offer DMA on the Indian exchanges," said Scott Field-Marsham, Managing Director, Head of Electronic Trading in Asia, Morgan Stanley. "Having DMA capability in this important market further enhances Morgan Stanley Electronic Trading's global footprint, which is of critical importance to our clients."
Morgan Stanley executed the first DMA trades after receiving formal approval to deliver DMA to FII (Foreign Institutional Investor) registered firms for both equities and listed derivatives on the National Stock Exchange, and for equities on the Bombay Stock Exchange. In addition to FIX approval, Morgan Stanley's proprietary electronic trading application, Passport Windows, has been certified by both the NSE and BSE.
"Today's announcement not only highlights Morgan Stanley's leadership in electronic trading, but it also underscores our commitment to offering our clients best-in-class execution services in India," said Parag Gude, Managing Director, Co-Head of Equities in India, Morgan Stanley. "We believe the DMA product will be a strong compliment to our existing market leadership in sales trading and research."
Morgan Stanley is a leading global financial services firm providing a wide range of investment banking, securities, investment management and wealth management services. The Firm's employees serve clients worldwide including corporations, governments, institutions and individuals from more than 600 offices in 33 countries. For further information about Morgan Stanley, please visit www.morganstanley.com.
Media Relations Contact:
Mary Claire Delaney, 212.762.6880
Carissa Ramirez, 212.762.6834
For media inquiries, send an email to Media Inquiries


Honorary Scripting Guy Boe Prox will be speaking for the Mississippi PowerShell User Group on Tuesday, September 10th at 8:30pm Central Time.
Windows Server Update Services (WSUS) is an extremely useful enterprise patching solution from Microsoft that allows you to keep your systems up to date with various types of patches. Boe is going to show us how to hook into the API and generate your own reports, view the configuration of the server and the application and synchronization events as well as automate your approvals using PowerShell.
Boe Prox is a Senior Windows System Administrator with 10 years of experience in IT. He works with a variety of Microsoft technologies such as WSUS, Active Directory, DNS and SQL as well as scripting with PowerCLI on VMware. He loves to find ways to automate repetitive tasks with PowerShell as well as creating useful reports that others can use. He is an Honorary Scripting Guy courtesy of Hey, Scripting Guy! and has numerous articles on Hey, Scripting Guy! as well as on the PowerShell Magazine and Powershell.org. He maintains a PowerShell blog at http://learn-powershell.net and has a number of projects that he works to maintain on codeplex (PoshWSUS, PoshPAIG, PoshEventUI and PoshChat).
Our monthly meetings are held online on the second Tuesday of each month at 8:30pm Central Time and are free to attend. The system requirements to attend these online meetings can be found on the MSPSUG website under the "Attendee Info" section.


This man was having a ritual bath in the holy waters of the Ganges in Varanasi (Benaras).
It was early in the morning, the water was cold and the back lighting was providing an amazing atmosphere which can only be seen in winter.
This young man was bathing in the holy waters of the Ganges in Varanasi (Benaras).
"You will see your life for what it really is: a small blip on the canvas of eternity.
This is a picture of Anand's brother who is a ship carpenter along the Ganges in Varanasi (Benaras).
Like his father his work is to fabricate, assemble, install and repair wooden boats which will never leave the shores of the Eternal city.
This is a close-up of Anand's face shot at the upper terrace which is on the top of my office in Varanasi (Benaras).
Since many seasons he is modelling for the pictures of our collections.
In a country where the "fairer is better" ideology is promoted everywhere, it is breaking a social and cultural taboo to enhance dark skin complexions like his skin.
It was Friendship day today in India and in many Asian countries, with Anand's smile I wish a better tomorrow to my friends and to anyone who will take the time to read those words.
This was shot along the Ganges at Venimadhava ghat in Varanasi (Benaras) on a Sunday morning.
Ayurveda is an ancient system of medicine that was developed in the Indian subcontinent hundreds of years ago.
According to the principle of Ayurveda, the human body is composed of a unique mixture of energies, called 'dosha'.
This unique mixture differs from person to person.
person's 'dosha' determines the kind of lifestyle that that person should lead, the ailments he or she will be susceptible to, the sort of food to be partaken, etc.
Thus Ayurveda bases treatment based on a person's unique 'dosha'.


Hi Peter, this picture is a mystery. The table and the things on it look abandoned and at the same the place lives, it is as if we are going to sit down at that table with you.
Where is the coffee? And you must have had two cameras. And there are two journals, and oh, you are wearing glasses, and the pens, are they feltpens or inkpens..
The tall black cylinder in the center is a coffee travel mug, I almost always have 2 camera's one color,one B+W. the journal on the left is for writing verbal images, the one on the left is outlines of projects. The pens are two kinds of ink pens in two colors Red for recording color images and black for black and White images. Two more reporters notebooks reside in a pocket one a daily [my mind] plan one a shot film log.
So you have lots of notebooks, I like that idea and would love to browse through these notebooks (well I wouldn't cause I know this can be pretty private!). So you do have a daily plan…?
But I wonder what a shot film log is?
Yes the tall black cylinder does look like a lens case. I am sure that it is supposed to since it is made by Nikon, a gift for judging a local photography contest and an excellent travel cup. Notebooks everywhere my life in pen and ink scribbles, a weekly plan, project outlines, model lists, etc. The film shot log is for noting each image I take place date exposure. this makes it easier to remember for dating prints, and tracking what is wrong with an image on the rare occasion [lol] I am unhappy with the technical quality. As the eyes get older this is a more helpful tool.
Peter, thanks for giving me a glimpse into the photographer's univers! Now that is why the coffeetravelcup looks like a Zoom and now I know what a film shot log is! I guess it took a lot of passion and patience and trial and error to become the photographer you are today. Thanks for sharing you insights and poetry too!


Files must be under 3 MB for members and under 2 MB for guests, they must be of a gif,jpg,jpeg,png,bmp and they must not be pictures with adult content or illegal activities.
Yes, there is a limit of 2 GB per image for guests and 4 GB per image for members. Our service is not designed to handle hosting for large (i.e.: high traffic) web sites.


Sit on your balcony and enjoy your ocean view. Has a beautiful lobby, inviting pool, large exercise room and sauna. Close to Hawaii Convention Center, shopping, restaurants, marina and Ala Moana State Recreation Area and Beach.