text:
The Anopheles gambiae salivary apyrase: promoter sequences of the mosquito gene confer salivary gland expression in Drosophila melanogaster.
The salivary glands of blood-sucking arthropods play an essential role in the adaptation to the haematophagous style of life in virtue of the salivary antihaemosthatic factors which are injected into the host skin during blood feeding. Haematophagy has arisen independently several time in different insects and one of the results of this evolutionary convergence is that a large variety of molecules have evolved to accomplish the same or similar functions. Completely diverse substances act as vasodilators and anti-clotting factors in different blood-feeding arthropods whereas antiplatelet activity is usually provided by the apyrase, an enzyme that hydrolyzing the ADP released by injured cells removes a critical factor promoting aggregation and recruitment of platelets. The only mosquito apyrase characterized so far is the Aedes aegypti gene which is a member of the 5'-nucleotidase family (Champagne DE et al, 1995, Proc Natl Acad Sci USA, 92: 694-698). We have previously identified two short Anopheles gambiae cDNA fragments showing similarity to the Ae. aegypti apyrase and to several members of the 5'-nucleotidase family. Based on their expression profile we proposed that the first one, whose expression was restricted to adult female glands, was the An. gambiae apyrase while the second, that was expressed also in other tissues and in males, represented a 5'-nucleotidase (Arcà B et al., 1999, Proc Natl Acad Sci USA, 96: 1516-1521). To investigate the evolutionary relationship among these two members of the same protein family we isolated the full-length cDNAs and named the corresponding genes AgApy (An gambiae apyrase) and AgApyL1 (An gambiae apyrase-like 1). The putative AgApy and AgApyL1 proteins are respectively 557 and 570 aminoacids in length and show high degree of conservation to the Ae. aegypti apyrase and to several other members of the 5'-nucleotidase family. The presence of an aminoterminal signal peptide and the absence of transmembrane domains or GPI-anchoring signals suggests that they are both secreted proteins. This prediction is confirmed by the observation that myc-tagged recombinant versions of the proteins are secreted in the cell culture medium after transient transfection of COS7 cells. The developmental expression profile of the AgApy and AgApyL1 genes was analyzed by reverse-transcription PCR. The AgApy mRNA was found only in adult females and, moreover, the transcript abundance increased shortly after blood-feeding, a pattern of expression perfectly consistent with the role of the apyrase in blood feeding. The expression pattern of AgApyL1, instead, seems compatible with a possible role of 5'-nucleotidase. Indeed, the AgApyL1 transcript was found not only in females but also in different larval stages and, at a lower level, in males and in early pupae. Because of our interest in potential applications of salivary gland promoters we have isolated the genomic region encoding the An. gambiae apyrase gene. We placed an 800 bp fragment located immediately upstream of the AgApy gene in front of the Escherichia coli LacZ reporter gene and we inserted it in the Drosophila melanogaster genome by P element-mediated germline transformation. A weak but specific beta-galactosidase activity was detected in the D. melanogaster glands showing that transcriptional regulatory elements responsible for the stage- and tissue-specific expression are conserved between the mosquito An. gambiae and the fruitfly.
Titolo: The Anopheles gambiae salivary apyrase: promoter sequences of the mosquito gene confer salivary gland expression in Drosophila melanogaster.
Lombardo F.
Di Cristina M.
Spanos L.
Louis C.
Coluzzi M.
ARCA', BRUNO
Abstract: The salivary glands of blood-sucking arthropods play an essential role in the adaptation to the haematophagous style of life in virtue of the salivary antihaemosthatic factors which are injected into the host skin during blood feeding. Haematophagy has arisen independently several time in different insects and one of the results of this evolutionary convergence is that a large variety of molecules have evolved to accomplish the same or similar functions. Completely diverse substances act as vasodilators and anti-clotting factors in different blood-feeding arthropods whereas antiplatelet activity is usually provided by the apyrase, an enzyme that hydrolyzing the ADP released by injured cells removes a critical factor promoting aggregation and recruitment of platelets. The only mosquito apyrase characterized so far is the Aedes aegypti gene which is a member of the 5'-nucleotidase family (Champagne DE et al, 1995, Proc Natl Acad Sci USA, 92: 694-698). We have previously identified two short Anopheles gambiae cDNA fragments showing similarity to the Ae. aegypti apyrase and to several members of the 5'-nucleotidase family. Based on their expression profile we proposed that the first one, whose expression was restricted to adult female glands, was the An. gambiae apyrase while the second, that was expressed also in other tissues and in males, represented a 5'-nucleotidase (Arcà B et al., 1999, Proc Natl Acad Sci USA, 96: 1516-1521). To investigate the evolutionary relationship among these two members of the same protein family we isolated the full-length cDNAs and named the corresponding genes AgApy (An gambiae apyrase) and AgApyL1 (An gambiae apyrase-like 1). The putative AgApy and AgApyL1 proteins are respectively 557 and 570 aminoacids in length and show high degree of conservation to the Ae. aegypti apyrase and to several other members of the 5'-nucleotidase family. The presence of an aminoterminal signal peptide and the absence of transmembrane domains or GPI-anchoring signals suggests that they are both secreted proteins. This prediction is confirmed by the observation that myc-tagged recombinant versions of the proteins are secreted in the cell culture medium after transient transfection of COS7 cells. The developmental expression profile of the AgApy and AgApyL1 genes was analyzed by reverse-transcription PCR. The AgApy mRNA was found only in adult females and, moreover, the transcript abundance increased shortly after blood-feeding, a pattern of expression perfectly consistent with the role of the apyrase in blood feeding. The expression pattern of AgApyL1, instead, seems compatible with a possible role of 5'-nucleotidase. Indeed, the AgApyL1 transcript was found not only in females but also in different larval stages and, at a lower level, in males and in early pupae. Because of our interest in potential applications of salivary gland promoters we have isolated the genomic region encoding the An. gambiae apyrase gene. We placed an 800 bp fragment located immediately upstream of the AgApy gene in front of the Escherichia coli LacZ reporter gene and we inserted it in the Drosophila melanogaster genome by P element-mediated germline transformation. A weak but specific beta-galactosidase activity was detected in the D. melanogaster glands showing that transcriptional regulatory elements responsible for the stage- and tissue-specific expression are conserved between the mosquito An. gambiae and the fruitfly.


Join this session with panelists Ajay Kaul, Eric Alessi, Eric Shonebarger, Irwin Goldstein on electronic standards. What does the future of electronic communication mean to the promotional products industry and how will we get there? In this session, you will see a clear road map for electronic communication in the industry and leave with a plan to utilize to help your company become significantly more efficient.
As a seasoned Product Manager, Ajay Kaul, has had proven success managing entire product line lifecycle and delivering a variety of time-critical solutions including Integration solutions, E-commerce solutions, Microsoft ecosystem marketing launches, and a mobile network construction solution. Experience managing onshore and offshore software development and support teams. Substantial Business Analyst experience includes building requirements specifications from user needs, creating functional and testing specifications.
Irwin Goldstein has been the Director of Application Development at HALO Branded Solutions since 2005.


text:
The Avenging Chance and Other Mysteries from Roger Sheringham's Casebook (2004) by Anthony Berkeley
I decided to delve into some short stories for today's review, which concerns a collection edited by Tony Medawar and Arthur Robinson and published by Crippen & Landru. The stories were originally written from the 20s to 40s, and this collection puts together work which has not been published since their original publication. The two editors for this collection write a very informative introduction, which caters for the novice Berkeley reader, as well as the reader who is more familiar. The introduction in the main focuses on the character of Roger Sheringham and his novel appearances. The parallels made to other writers' work when discussing these novels were of particular interest for me.
Before we get to the short stories this collection also includes a "biography" Berkeley wrote for Sheringham, which was originally included in the US editions of Dead Mrs Stratton a.k.a. Jumping Jenny. The appendices also contain two further pieces by Berkeley: 'Why Do I Write Detective Stories' and 'The Body's Upstairs, A Parody' by A. B. Cox. This latter narrative is quite amusing as Sheringham is consulted by a writer who has lost a really great idea. Has it been stolen, or is it just misplaced? Apparently, it is a three-barrel problem…
Whilst you are pondering that, let's take a look at the short stories…
The Avenging Chance (1929)
This is Berkeley's best-known short story and is widely regarded as a classic. Many of you will no doubt know that this short story is the basis for Berkeley's novel, The Poisoned Chocolates Case (1929), (which was reprinted by the British Library a few years back).
Unlike in the novel the focus is not on the multiplicity of possible solutions to the poisoning of Joan Beresford, but on the chance factors which enable Sheringham to figure out what really happened. Nevertheless, we do see some pieces of evidence in the short story which have more than one interpretation. I think this is a rare example of a great short story made even greater by being put into a novel format. We also get some get good comic lines from Berkeley, such as when Sheringham is dining with a man who claims he knew Graham Beresford really well. Yet of course it is all exaggeration and we have Sheringham 'realising that his host's actual contact with Beresford at school had been limited, at the very most, to that of the latter's toe with the former's hinder parts.' Final thought does anyone think that Berkeley chose Beresford as the surname for the married couple as a way of poking fun at Christie's perfect married couple Tuppence and Tommy Beresford?
Perfect Alibi (1930)
Like the previous short story this one is a 'compressed version of the novel The Second Shot' (1930). This time Sir Wilfred, a chief constable, is telling Roger about the death of Eric Southwood. Eric is a notorious and debt ridden rake who is keen to marry the young wealthy Elsa Pennefather, much to the distress of her family. So it seems rather convenient that during a house party he ends up accidently shooting himself when trying to get a shotgun out of a bramble patch. We all know it is murder but who could have done it? The ending to this tale is rather abrupt and I think the premise is better worked out in its novel format.
The Mystery of Horne's Copse (1931)
Hugh is walking on air as he goes home through Horne's copse one night after bidding his fiancée goodnight. Yet his upbeat mood soon sinks when he stumbles across the body of his ne'er-do-well cousin Frank Chappell. He has been shot in the head, though he and his wife were supposed to be in Europe on holiday. Hugh races home to call for help but when he, the police and the local doctor go back to the scene, the body is not there. Moreover, a reply to the telegram sent to the hotel Frank and his wife are staying at also seems to reinforce Frank's alive status. Hugh thinks no more about it until one month later it happens again! Though this time Frank is stabbed. Once more the body disappears. Is Hugh going mad? He seems to think this is the case when it happens a third time. But this time the body doesn't disappear, and the police are hot on Hugh's heels to arrest him. What is going on? This story has some tones in common with Mr Priestley's Problem (1927), but it is a darker story, given the sinister plot unravelled. That said the tension is not racked up as much as it could have been.
Unsound Mind (1931)
Chief Inspector Moresby receives a phone call from a man who wishes to inform him that he is about to commit suicide using prussic acid. The caller is Dr James Carruthers, and unfortunately despite their best efforts the police cannot save him. Yet Moresby is unsatisfied with this so-called suicide. The note seems wrong, as does the victim's change of heart when it came to which poison they took. The ending to this one is good, and I found Berkeley's use of the victim in the tale very interesting.
White Butterfly (1936)
This time Chief Inspector Moresby asks Roger Sheringham to look into the disappearance of Mrs Warrington at Clearmouth. She supposedly left her husband 6 weeks ago to go to her married lover. But rumour has it that her husband killed her instead. There is not enough to go on for the police to get further involved, hence inviting Roger's help. This story is one which demonstrates Sheringham's fallibility humorously well and I think it is fair to say that he almost solves the case in spite of himself.
The Wrong Jar (1940)
The next case Chief Inspector Moresby asks Roger to get involved in is the poisoning of Cynthia Bracey at Marston. That she was poisoned using arsenic put in her medicine is indisputable. But when it was put in and who put it there is highly debatable. Cynthia's husband is currently being held by the police, but Moresby is sure they are on the wrong track. I had a rather different solution in mind for this one and felt the one Berkeley went with a little bit unsatisfactory. The proof of the guilt lacked substance.
Roger does not have Moresby by his side in this story, but his old friend Alec Grierson, who first cropped up in The Layton Court Mystery (1925). Roger is called in to look at the Monckton Regis case. James Meadows has been arrested for the murder of Mrs Greyling and his sister is determined to prove his innocence. But this will not be easy. Several witnesses claim to have seen a man which looked like him, in a car like his, shoot Mrs Greyling three times in the head. Whilst his alibi was waiting in a remote part of a woods waiting for Mrs Greyling to turn up for a picnic. My brain having warmed up to the way Berkeley approaches his mystery writing, I soon figured out what was going to happen. A well told story but not the most of deceptive of mysteries.
"Mr Bearstowe Says…" (1943)
This story was 'an adaptation of a radio play broadcast in 1940, "Red Anemones"; both may in fact be considered adaptations of "Razor Edge," a short story apparently not published in Berkeley's lifetime.' The tale begins in 1939 at a beer and sausage party in Bloomsbury. Roger is not enjoying himself and gets landed with an awkward guest to talk to. The woman in question is obsessed with another guest called Michael Bearstowe, a good-looking sponger who preys upon married women. Berkeley puts it well when he writes that:
'She's in love with him, he thought without enthusiasm, as he noted the pleasure, singularly tinged with relief, or even gratitude, which at once illumined his companion's face. He wondered who this Bearstowe was, and why he was not looking after his own, as he prepared for the worst. He received it.
A flood of Mr Bearstowe promptly poured over him. "Mr Bearstowe says…" Roger wondered how Mr Bearstowe found time to say so much.'
Two years pass and it is mere chance that Roger is with the police when a Mrs Hutton reports her husband missing after he said he was going to go swimming in the sea. Mrs Hutton of course is the mystery woman of the party, but why should she faint when Roger mentions Bearstowe's name? The solution is a good idea, but again is a little bit too theoretical.
I am more of a novel reader than short story fan, but I did expect to enjoy these stories more. I like the twisty nature of Berkeley's prose, but I didn't feel as though I enjoyed it as much as I do when I read his novels. Perhaps the solutions are better prepared for in the novels? Thankfully I have Panic Party in my TBR pile, so I will hopefully get around to reading that at some point.
Anthony Berkeley
Crippen & Landru
Roger Sheringham
Previous Stone Dead (1947) by Patrick Laing
Next My 1100th Post – Christie's Critters: Assistants, Avengers and Animal Imagery
thegreencapsule says:
First off, I'm jealous that you managed to get your hands on this. Funny how books published in recent years can be hard to track down. Second, thanks for the heads up on the link between the short stories and the novels. It looks like this is one to hold onto until I've read a few more books by Berkeley.
It is available in kindle at Amazon (also some copies in paperback)
I believe a second edition is available in paperback and ebook from C&L is available so it might be easier to track down.
The short stories have different solutions to the novels, but yes you might appreciate the novels more not having read the short stories first.
I'm a Berkeley fan, as you know, and I have to say that his short stories typically seemed a bit more suited to his ideas, sometimes — as if he has enough for something to be a decent short story ('Perfect Alibi', say) and then expands it into a thorough trudge of a novel (The Second Shot, as you point out). Still, it's been many, many years since I read any of his short fiction, so I might have a different opinion of these now. Like Ben, I'll hope to track a copy of this down; unlike Ben, I'll probably have to pay a lot of money for the privilege 😉
Oh I forgot that you didn't enjoy The Second Shot as much as I did.
If you have a kindle you can get access to this collection much more cheaply than if you want a hard copy. Surprised you haven't come across a second hand copy during your book shop hunts.
I think my disappointment in TSS has been heightened by how good the shorter version is.
neeru says:
Haven't read Berkeley. perhaps one of these days…
He can be a bit tricky to track down but the British Library reprinted his novel The Poisoned Chocolates Case a few years back. I also did a post last year ranking the titles by Berkeley that I have read. That might give you some pointers as to which book you would like to read first:
https://crossexaminingcrime.wordpress.com/2019/11/23/ranking-the-work-of-anthony-berkeley/

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: Django collectstatic AWS S3 Eu tenho uma dúvida referente ao collectstatic. Estou usando o Free Tier da Amazon e percebi que ultrapassei o limite de uso do S3 PUT pois fiz vários collectstatic. Estava um dia desenvolvendo no próprio ambiente de amazon por preguiça e a cada mudança no JS que eu fazia, como não sabia fazer collectstatic de 1 arquivo, fazia geral.
A forma mais eficiente no caso de pequenas edições é fazer collectstatic -i folder/file.png (no arquivo ou pasta específica) ou preciso fazer geral? Como não sobrecarregar os envios do S3?
Sei que vacilei fazendo vários collectstatic em ambiente de "produção". Mas preciso fazer de todos os arquivos sempre?

A: O correto é você enviar apenas aquilo que você alterou, não faz sentido enviar 100MB de arquivos para o S3 se você alterou apenas 1 arquivo de 10Kb.
Eu normalmente organizo bem meus diretórios, exemplo:

*

*static/img/

*static/videos/

*static/videos/homepage

Ao rodar o collecstatic, ignore todos os diretórios que você não alterou, inclusive o 'admin'. Caso o arquivo que você alterou esteja em um diretório com muitos outros arquivos, você pode ignorar extensões também.
Em meu fabfile eu costumo criar um dicionário com a árvore de diretórios do meu static, e nele eu informo qual vai ser ignorado ou não, exemplo:
ignore = {
    'app': {
        'img': None
    }
}

Você pode criar a lógica e organizar como bem entender, em meu projeto fiz algo mais simples. A ideia é ignorar o diretório pai, ou indicar especificamente os diretórios filhos.

redpajama_set_name: RedPajamaStackExchange


Look and Read. Includes stories, nursery rhymes, songs, games, and videos.
NEW! Learn about your favorite subject. Look up words. Read magazines, newspapers, biographies, primary sources, country information. Find pictures. Translate articles into more than 30 languages.
Learn about people, places, animals, sports, and more. Includes videos, images, maps, games. Hear text read aloud.
Text, images, charts and graphs, and educational videos from books, magazines, and news periodicals on interesting and important facts with connections to current and past events.
Google's visual search engine for kids.
1. Safe sites and pages written specifically for kids.
3. Most search results are illustrated with big thumbnails, which makes it easier to scan the results, see the differences among them, and click on the most appropriate results.


Brit Gilmore, a native of Detroit, is president of The Giving Keys, a company that exists to employ people transitioning out of homelessness in Los Angeles to make inspirational jewelry and accessories. Each wearer of a giving key is meant to embrace the word on their key and pass the key on to a person they feels needs the message more than them. The self-funded company's products are carried in over 1,400 stores worldwide including Nordstrom, ASOS and Fred Segal. The Giving Keys has created more than 80 jobs for people transitioning out of homelessness. Brit is passionate about job creation for community transformation and using business to build self-esteem and break cycles of poverty. Brit lives in Venice, California, with her husband, Ryan who worked for TOMS. Brit and Ryan believe social business is the way of the future.


"Double kill" is a bragging term from the world of violent video gaming – it means you finished off two assailants with a single shot.
In the world of cybercrime, it's the name given by Chinese computer security compay Qihoo to what it claims is an Internet Explorer zero-day hole that's being actively exploited in the wild.
As you probably know, zero-day exploits get their name because they show up in the hands of attackers before an official fix is available, thus giving zero days during which even a keen and well-informed sysadmin could have applied a patch.
If there isn't a patch you can use, the next best thing is some sort of workaround that minimises or eliminates the side-effects of the bug in your environment.
Unfortunately, in this case, Qihoo isn't giving much away: we've seen only very sketchy details of how the "double kill" exploit works, or what you could look out for if an attacker tried to use the exploit against you.
All we know so far is that a "double kill" attack starts with a Word document, presumably sent as an email attachment.
If you open the booby-trapped document, which is denoted by Qihoo as containing some unspecified sort of shellcode, Internet Explorer is apparently activated in the background, ultimately leading to an executable program being downloaded and executed without any visible warning.
…the first Office Document based exploit that uses a browser zero-day vulnerability to carry out the attack. Opening a malicious Office document may cause infection with a Trojan horse that can take full control of the victim's computer […] Hackers carried out the APT attack by delivering Office documents containing malicious webpages. When affected users opened the documents, malicious scripts and payloads using the vulnerability were downloaded from a remote host and executed.
Which document file formats (e.g. RTF, DOC, DOCX, XLS, XLSX, PPT, PPTX) can be used to trigger this vulnerability.
Whether the booby-trapped Office files contain macros or other active scripting that could be detected and blocked generically to reduce the risk of attack, at least until specific details are available.
Whether Office is required to make the exploit work, or whether other applications might be able to trigger it too, such as PDF readers or video players.
How Internet Explorer comes into the attack.
Qihoo's diagram shows a document containing shellcode, plua various DLLs (executable files) that are apparently written to disk after the document is opened, but Internet Explorer is not depicted in the diagram at all.
Numerous secondary aspects of the attack are mentioned by Qihoo, including a trick used to bypass User Access Control (UAC), the download of an image file with executable code hidden inside it, and the execution of that code by poking it directly into memory without first saving it to disk.
At a later stage of the attack, it uses a publicly available UAC bypass technique, file steganography [executable content buried inside an image file] and reflective DLL injection [poking a program directly into memory] to avoid file detection.
At this time [2018-04-24T23:30Z] , we don't have any sample files from an actual attack; we don't know whether booby-trapped documents have any telltale signs that you can look out for; we don't know how Internet Explorer comes into the attack; and we don't know whether Office is the only applciation that can be used to trigger a "double kill".
All we can do it to reiterate the general security advice we have given many times before: don't open documents you weren't expecting, even if they seem to be urgent or interesting.


text:
FEATURED BLOGGER: Most Exciting Pre-season in years?
Written by – Kirsty Swann
I think all stags fans will agree with me when I say that this has to be the most exciting pre-season that we have had down the mill in many years, with only a week after the final game of what was a good season for us we had season ticket news, players coming and going and just a general buzz around the place.
In recent years we haven't had this kind of buzz in pre-season with it taking weeks after the season had ended before we found out any news.
I think a lot if this is down to the appointment of Steve Evans who is certainly a man who doesn't like to sit around and let opportunities pass him by, he also brings with him great knowledge and professionalism we haven't had before in a manager due to his connections.
The signings that have been made by Evans have been very good and have definitely got the stags fans excited for the coming season, which is also very evident with the amount of season tickets that we have sold which are in the region of 2,000+ which means we are going to have a cracking atmosphere at the ground next season.
Arguably the biggest news to come out the club this past week is that we have arranged a friendly with Sheffield Wednesday in July, even though this is just a pre- season game it's a massive game for the club in more ways than one, with it bound to be a big financial boost for the club due to Wednesday's massive away following, but it also brings a massive test for Evans new look squad ,who will face off against a club which have reached the play offs in the championship for the last two seasons.
There are also plenty of rumours flying around this week with regards to new signings coming into the club over the next few weeks, I don't know about you but I can't wait for the new season to roll around.


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Life is an Outlaw: A Biologist Challenges the Central Doctrine
by Whitney Smith , Chris Lowry
Standfirst
THE WILD CULTURE INTERVIEW: IGNACIO CHAPELA. Unlike math and physics, biology is a messy science whose essence is diversity. What if the so-called natural laws that keep agribusiness on well-worn paths are bad for nature — and self-destructive for us? Chapela, a biologist at UC-Berkeley and an active member of the European Network of Scientists for Social and Environmental Responsibility, explains what kind of mentality is needed to win against the new biotechnologies. Interview by Whitney Smith and Chris Lowry.
Drawing by Efrain, 12, El Porvenir, Guatemala. "A man and his son are working cleaning the crops because it is the time of the year to do it. Corn and beans are important food for Guatemalans. What I also represent is the value of planting our food." [o]
WHITNEY SMITH In terms of the work you're doing today as a biologist and ecologist, what most concerns you?
IGNACIO CHAPELA A very important problem today is our failure to fruitfully understand, interact and deal with a fundamental principle of biology: diversity. It's not only the fact that we're losing diversity, but that we're losing it because we lack the imagination and intellectual capacity as a culture to understand and to behave coherently in relation to this principle. High input monoculture farming implies loss of genetic diversity. Why do we need to do that? There are many ways of dealing with food production, agriculture and forests, many ways that do not require monocultures. But it is our way of understanding and approaching biology, approaching life that eventually forces those diverse systems to become less and less diverse, more and more homogeneous, to fit our idea of what is optimal or what is good.
You cannot have sustained collective critical inquiry at the same time as having a hierarchical structure.
What moves biology is diversity, change, fluidity, the fact that nothing is set, and that there are no rules and no laws. The effort of trying to produce something equivalent to Newtonian physics in biology has failed over and over, and yet we stubbornly keep coming back and attempting to impose these laws of nature that don't exist onto nature that is crying back to us about how wrong we are. You see it over and over again in biotechnology. It doesn't deliver on its promises, ever. And yet, we stubbornly continue to expect those laws to rule the biological world, when they don't.
CHRIS LOWRY Yes, driven by man as homo economicus — that everything is seen through the lens of profit maximization. A person who is part of the dominant paradigm would say biotechnology works well. "Monsanto's monoculture works very well, thank you very much."
CHAPELA And makes money.
LOWRY And maximizes yield. And they would say, from their point of view, biotechnology is a success.
CHAPELA I agree with that, except that the economic maxim is a daughter of the problem. It is not the problem, it is simply one of the expressions, one of the descendants of the root problem. And the root problem is, it's a misalignment between the way we understand and the way things are. So yes, Monsanto makes money, which is really the product. They do not necessarily produce more volume. For instance, the productivity of a monoculture in the American Midwest is just terrible, and it's coming to an end. Whereas the productivity of our high diversity field in Oaxaca, in a Milpa system [a traditional intercropping system of regional vegetables], productivity and yield are very high. There are many ways of analyzing this, even with the concepts of econometrics. If you look at yield, and you include the yield not only of the carbohydrates you're pulling out in the form of grain but also the nutrition in vitamins and minerals, if you include health factors as yield, there's just no comparison between an acre of Iowa cornfield and an acre of Oaxaca Milpa. An acre in Iowa is mining that will never be sustainable, whereas an acre in Oaxaca has been producing for 10,000 years and will apparently continue to produce for that long if allowed to do so.
A combination of factors increase microbial diversity. Green arrows indicate higher diversity and red arrows indicate lower diversity with arrow thickness representing the strength of the effect. [o]
SMITH From the beginning of our conversation you've said that the loss of diversity is largely through a lack of imagination in our culture. When you talk about imagination, do you mean openness, and the act of opening one's mind to possibilities we might not be used to?
CHAPELA Yes, I think that is the point, it's openness to the other. In my world as a biologist, which is the world of the living, I need to make a strong distinction between the living and the non-living. The world of the living is so diverse and different that it takes training of the human mind to recognize that there are other ways of being. For example, a rewarding part of the process of becoming a mature biologist is to learn about the incredible diversity of sexual systems and reproductive systems (while acknowledging that sex and reproduction are different subjects). If you look at fish, then look at mammals, then if you look into the world of microbes, whoa! The world is bewildering in its diversity of sexual systems, reproductive systems, and systems of interaction that, on first inspection, we would have interpreted as sex, but then turn out not to be sex. This is a process by which a biologist is trained, through the exploration of living systems, to keep the mind open. In our education systems we seem to be anti-prepared for the world of the living; we seem to be hell-bent on bringing it into bounds and resistant to the possibility of other ways of being and other ways of living.
SMITH So in a sense, to have imagination is to have an image of the other, but also to have an image of how the other sees the world.
CHAPELA Yes, beautiful.
LOWRY And it requires humility. You were referring to, in a way, an all-species perspective in biology, and, as a biologist, you become aware that you want to think that the other is other living things, other creatures, other species, as well as other humans. However, as much as you want to, you can't. As David Ehrenfeld said in The Arrogance of Humanism, the problem with our humanist tradition, coming from back to Plato, is that it's arrogant, anthropocentric and hierarchical. We're on top and we're looking down on everything nonhuman.
Diversity in marine biology . . . How does species richness vary with ecosystem productivity for phytoplankton? The hump-shapes offer a clue. [o]
CHAPELA If you are humble, like you said, and if you have the opportunity to meet the Other, either in your backyard or in the soil, or by travelling the world, this Truth of the Other jumps out and becomes self-evident. I was raised in Mexico and I didn't go to college in the US, but I'm very interested in questions about education. I remember in the 80s when an education policy in the US removed three subjects from the curriculum of elementary school teaching: biology, geography, and history. These subjects teach you about the other: knowledge about the other living things that are non-human; knowledge about the other that lives in different parts of the world; and the other that has lived in different times in history. That was an incredible moment in the 80s of closing down the focus and saying, hey, now we're really just focusing on us.
SMITH And it was in 1987 that the book The Closing of the American Mind, by Allan Bloom, became a huge bestseller.
CHAPELA Exactly.
SMITH Here's a scenario I'd like you to consider. You've been invited to speak at a conference of elementary school curriculum designers, and you're there because they want to know more about this question that you have about the lack of understanding and imagination in relation to the subject of diversity. This is a priority for them, and they want to figure their way out of it in the next ten years, it's not a quick project. How might you steer them?
CHAPELA Embracing the openness of diversity is a very scary prospect. It becomes very threatening, very daunting, and there is a huge amount of resistance. I have tried, and I continuously keep trying, on the biology curriculum. To give an example, there is a concept out there called the central dogma. It is the idea that you have a code somewhere that is written up, that has the instructions for how you're going to make things so that their form and their function are pre-encoded in this code. The concept of central dogma is something we all have to accept in order to pass exams, in order to graduate, all the way to the professional geneticists and ecologists who have to contend with it. So, you say to a middle school teacher, "You're going to teach without the central dogma. In fact, you're going to teach against the central dogma." They're going to say, "Well, how am I going to explain heredity and evolution? Give me something equivalent that is as powerful and as useful that applies throughout all fields in biology, and I'll go with you." It reminds me of where I come from, which is from a Catholic background in Mexico. To change the way we teach about biological diversity is similar to the ideological and imaginary castle of Catholicism — a stable institution and frame of mind. The Catholic Church has survived nation states, empires, world wars, whatever you throw at it, partly because it has such beautiful and elegant imagery and makes so much sense — as long as you don't question the fundamental dogmas. We have come to a time in the development of biological practice and teaching that feels and looks very much like religious trappings of something as beautiful and as toxic as the Catholic Church.
On the one hand, this is one kind of science. The other science that also carries that word, as a label, is one that my friend Ian Ball, the historian, defines with four words: sustained, collective, critical inquiry. It is a human activity that is about asking questions, doubting, and doing it collectively. This means we share with people who are alive and people who are dead, sharing our understandings and not giving up on questions. Sustained, collective, critical inquiry. This way of understanding does not lead to a pyramidal hierarchy. It is a more flexible, horizontal and dynamic network of people committed to inquiry. You can see how one is completely opposed to the other. You cannot have sustained collective critical inquiry at the same time as having a hierarchical structure. You cannot have them both. This is the schizophrenic nature of science today, in that 'science' is a word behind two different understandings of who we are in the world and what the world is about — and it's a continuous back and forth between these two ways of understanding.
The monolithic "rule of the laws of nature" mentality wants one answer to solve every problem.
SMITH I want us to go back to this place where you're about to finish your talk at the conference of curriculum designers, and they're inspired by what you're talking about, but they're confused. They're thinking, okay, I'm on board, but how do I do it? What are you going to leave them with?
CHAPELA I'd leave them with a practice, a practice that requires exercise that, first of all, includes what Chris mentioned: humility. And secondly, a practice that invites curiosity for the world, and openness to accept what the world has to say, instead of imposing what we think the world is supposed to say back to us when we inquire about what it's doing. So, as a first step, the humility is necessary, and it needs to be practiced. We are born arrogant and we are raised arrogant. And so like any muscle, it requires exercise. And then the practice of observing and watching, but watching in order to learn from the other, in order to accept what the other has to say, rather than what I'm expecting the other to tell me.
LOWRY How would you advise them to defend themselves against the dominant paradigm as they go on this path and as they teach others — since it takes a lot of strength to be a nonconformist in any way?
CHAPELA I'm a member of the European Network of Scientists for Social and Environmental Responsibility, ENSSER, and within this organization, this is something we're confronting a lot. The people I talk to within that group are the biologists rather than the physicists, and that is a common understanding we have in ENSSER. And yet we also are in common understanding of how dangerous it is to try and butt heads against a system that is very monolithic and very strong and very powerful. So first of all, I would say, you need to survive as an individual, as a teacher, and in a network.
So networking and supporting is what we do in ENSSER. Making sure, before we come out bashing GMOs, we make sure that we are on the same plane. No going out wild as individuals. Develop networks, survive as an individual, teacher, survive as a network and reproduce – these are fundamental questions of our times. The fundamental motivation of the 20th century was produce, produce, produce! The key questions are biological questions: survival and reproduction.
Ignacio Chapela speaking on a panel about GMOs at an ENSSER conference, 2018, entitled, 'Bound to fail: the flawed scientific foundations of genetic engineering." [o]
SMITH In relation to what you've said about the lack of imagination in our culture, if you think ahead 30 years from now, you're an older man looking back, you still have your wits about you, and you heard about it, or read it in a newspaper that something happened that you never thought was possible — what would that be?
CHAPELA I don't want to read about it in the newspaper, I want to see it happening out in the world, at the smallest possible scale. Part of the monolithic "rule of the laws of nature" mentality is that it's a mentality that wants one answer to solve every problem, whereas I strongly believe in transformation that comes through answers that are small, localized, and time-specific. Detecting the appearance and maintenance of happiness through diversity is something that we are really good at detecting, really good at sensing it when it's there and not there. When you walk into a field and you see people dealing with a field that is diverse, powerfully rooted in its history, and deep in the physical roots of the soil, that's where there is an enormous amount of happiness — and it is very local.
SMITH Foraging for the diversity vibe . . .
CHAPELA Exactly. You can feel it when you're working with these two ingredients: small scale and local time. I believe in that and I have no doubt about it because I see it all the time. However, it's a struggle I don't think is going to go away in 30 years. ō
IGNACIO CHAPELA is a microbial ecologist and mycologist at the University of California, Berkeley. He is best known for a 2001 paper in Nature on the flow of transgenes into wild maize populations, as an outspoken critic of the University of California's ties to the biotechnology industry, and for his work with natural resources and indigenous rights.
WHITNEY SMITH is the Publisher and Editor of the Journal of Wild Culture. He lives in Toronto.
CHRIS LOWRY is a media producer and singer. Before working for many years in international development and sustainability, he made films on art and music. Chris was part of the original team that created The Journal of Wild Culturein 1986 and served as the magazine's Senior Editor. He lives in Toronto.
Submitted by Ana Ruiz Díaz (not verified) on Wed, 09/29/2021 - 18:04
Amazing piece with Ignacio…
Amazing piece with Ignacio Chapella! So wonderful his definition of science as collective critical inquiry., and so interesting his data about geography and history courses withdrawn from US school curriculum. It made me better understand its people. Thanks for this!
Ana Ruiz Díaz
biology, agriculture, Sustainable agriculture
When a Thin Place Discovers Us
Ecstatic Cities
Gaia and the Path of the Earth: Lovelock, Illich, Latour (Part 3)
Talking to Birds
A Dancer Mourning Charges Memory
A Rough Sex Scandal
Anarchist Anthropology: Power with Hierarchy
Rethinking Psychiatry
Journey to the Landfill
The Pattern that Connects: Gregory Bateson and the Ecology of Mind
Different Articles
Allan Savory's Plan to Reverse Climate Change, One Farmer at a Time
Farmers Rain on Monsanto's Parade
A Pipeline Runs Through Us
The Giving Walnut
George Monbiot: Feral - Wild Boar
The SPWC exists as much offline as it does here online (well, not really, but it sounds good.). View some forthcoming Wild Culture events.
@2021. Society for the Preservation of Wild Culture & Individual Contributors | Creative Commons Attribution 4.0 International License
Official journal of the Society for the Preservation of Wild Culture


A very traditional and perhaps forgotten Chinese takeout dish is Pepper Steak, which is simply beef, green bell peppers, and yellow onions cooked in a brown sauce. Honestly, this wasn't one of my favorite dishes to cook in the restaurant, but I've since developed a lighter, tastier remake. Using a colorful mix of peppers makes for a great presentation and substituting the yellow onion with fresh leek adds better flavor to this dish. You can also substitute scallions for the leeks (we used a variety of giant scallion that they have here in China, since we can't really find leeks around these parts).
Slice the beef into thin 3-inch strips. One good trick is to slice the meat when it is still slightly frozen, when it's easier to handle.
Mix the beef in a bowl with soy sauce, oil, and a teaspoon of cornstarch. Set aside.
Mix the last 1 tablespoon of cornstarch with a tablespoon of water and set aside.
Wash the peppers and leeks thoroughly (paying special attention to the leeks, which can be quite sandy). Chop the peppers and leeks into 1 ½ inch pieces. A lot of times, in Western cooking, people will discard the green part of the leek, which is a mystery to us. In this dish, we're using the entire leek! Mince the garlic.
Heat the wok over high heat until smoking, and add 1 tablespoon of oil to coat the wok. Add the dried chili peppers (if using).
Add the beef. The heated wok will give the beef a great sear and prevent sticking. Remove the beef and chilis from the wok and set aside in a small bowl.
Heat the wok to high again and add another tablespoon of oil. Toss in the bell peppers, leeks, and garlic.
Stir-fry for a minute and add the wine to deglaze the pan. Next, add the seared beef and chilis, the 2 kinds of soy sauce, sesame oil, salt, and sugar.
Mix well and stir-fry for another minute.
You should have a good sizzle going with some liquid at the bottom of the wok. If you like more sauce for your rice, add some chicken or beef stock. Finally, add the cornstarch slurry you made earlier to thicken the remaining liquid into a rich sauce. Serve immediately with steamed rice.
Slice the beef into thin 3-inch strips and mix well in a bowl with soy sauce, oil, and a teaspoon of cornstarch. Set aside. One good trick is to slice the meat when it is still slightly frozen, when it's easier to handle. Mix the last 1 tablespoon of cornstarch with a tablespoon of water and set aside.
Heat the wok over high heat until smoking, and add 1 tablespoon of oil to coat the wok. Add the beef and dried chili peppers (if using). The heated wok will give the beef a great sear and prevent sticking. Remove the beef and chilis from the wok and set aside in a small bowl.
Heat the wok to high again and add another tablespoon of oil. Toss in the bell peppers, leeks, and garlic. Stir-fry for a minute and add the wine to deglaze the pan. Next, add the seared beef and chilis, the 2 kinds of soy sauce, sesame oil, salt, and sugar. Mix well and stir-fry for another minute. You should have a good sizzle going with some liquid at the bottom of the wok. If you like more sauce for your rice, add some chicken or beef stock. Finally, add the cornstarch slurry you made earlier to thicken the remaining liquid into a rich sauce. Serve immediately with steamed rice.
This is the first time I've made a pepper steak dish that my family actually really liked. Thank you!
This looks great, definitely going to try it out this week!
Thanks Yvonne, Make sure when you heat the wok real hot in the cooking process and keep the veggies at room temp and you'll get that coveted wok hay flavor. It's ok to scorch the scallion and peppers which adds great flavor. Enjoy!


text:
import io

try:
    from setuptools import setup
except ImportError:
    from distutils.core import setup

with io.open('README.rst') as f:
    long_description = f.read()

setup(
    name='chatpy',
    version='0.3.0',
    packages=['chatpy'],
    url='https://github.com/aqn/chatpy',
    license='MIT',
    author='aqn',
    author_email='aqn000 at gmail.com',
    description='ChatWork API for Python',
    long_description=long_description,
    install_requires=['requests', 'six'],
    keywords="chatwork library",
    classifiers=[
          'Development Status :: 3 - Alpha',
          'Topic :: Software Development :: Libraries',
          'License :: OSI Approved :: MIT License',
          'Operating System :: OS Independent',
          'Programming Language :: Python',
          'Programming Language :: Python :: 2',
          'Programming Language :: Python :: 2.7',
          'Programming Language :: Python :: 3',
          'Programming Language :: Python :: 3.4',
          'Programming Language :: Python :: 3.5',
          'Programming Language :: Python :: 3.6',
    ],
    zip_safe=True
)

redpajama_set_name: RedPajamaGithub


text:
Live match preview – A Madrid vs Liverpool 19.10.2021
Team news and stats ahead of Atletico Madrid vs Liverpool in the Champions League group stage on Tuesday; kick-off 8pm.
Liverpool midfielder Curtis Jones has returned to light training but has not travelled to Spain for the Champions League tie against Atletico Madrid.
Manager Jurgen Klopp is hopeful the 20-year-old's recovery will be complete in time for him to return to the squad to face Manchester United on Sunday, with the game also coming too soon for Thiago Alcantara (calf).
Liverpool's Brazil internationals Alisson and Fabinho are both expected to feature having flown ahead to the Spanish capital after international duty at the end of last week, while Harvey Elliott (ankle) remains a long-term absentee.
Jurgen Klopp sees no reason why Mohamed Salah's performances for Liverpool wouldn't have him in contention for the Ballon d'Or accolade
Follow live updates on SkySports.com and the Sky Sports App from 6.30pm on Tuesday; kick-off 8pm. Also follow on Gillette Soccer Special live on Sky Sports News and Sky Sports Premier League from 7pm.
FREE TO WATCH: Highlights from Liverpool's win over Watford in the Premier League
Opta stats
Atlético Madrid and Liverpool last met in the last 16 of the 2019-20 UEFA Champions League, with the Spaniards winning both legs, 1-0 at home and 3-2 away in extra-time.
Liverpool have failed to win any of their four UEFA Champions League matches against Atlético Madrid (D2 L2), only facing Basel as often (also four times) without winning in their European Cup/Champions League history.
Liverpool have lost six of their last seven away UEFA European matches on Spanish soil (D1) since beating Real Madrid in the last 16 of the 2008-09 Champions League. The Reds' last win in Spain came against fellow English opponents, beating Tottenham 2-0 in the 2019 Champions League final in Atlético's home stadium, the Wanda Metropolitano.
Liverpool boss Jurgen Klopp was full of praise for opposite number Diego Simeone and the 'quality' job he has done at Atletico Madrid
Atlético Madrid are winless in four home UEFA Champions League matches (D3 L1), their joint-longest run without a home win in the competition (also four in December 2009). They have only scored once from 45 shots in this run and with an expected goal tally of 4.4, have netted 3.4 goals fewer than they would have been expected to score.
Liverpool haven't lost an away game in the group stage of the UEFA Champions League since September 2019 (0-2 v Napoli), winning five and drawing one of their last six such games. Jürgen Klopp's side have scored 18 goals and conceded just three times across these six fixtures.
Four of Atlético Madrid's last seven goals in the UEFA Champions League have been scored in the final 10 minutes of play, including each of the last three in a row. Excluding extra time, Luis Suárez's penalty (96:23) against AC Milan last time out was the latest game-winning goal in the UEFA Champions League since the start of the 2003-04 season (as far back as Opta have exact goal times).
Tags: live, Liverpool, Madrid, match, preview
Large tracts of La Palma, Spain, scarred by lava flows
Migrant crisis: Surge in numbers trying to enter Germany leaves Poland border at risk | World | News
Robbie Dunne lodges appeal against 18-month ban | Racing News
Russia invasion of Ukraine 'likely scenario' within weeks | World | News


text:
Q: Problem in minimizing expression I am trying to implement bootstrapping (https://en.wikipedia.org/wiki/Bootstrapping_(finance)) of CDS curve. To implement it I am trying to minimize a series of expression. The minimum value of expression will result from certain value of variable. I can easily do it in excel however trying to find a way in mathematica.
I am trying to find value of h1 and h2 in below code using Minimize function to minimize two expression.
'Minimize[Sum[50/10000*1/4*1/4*n*97/100*Exp[-h1*1/4*n], {n, 1, 4}] -
Sum[1/2*1/4*n*97/100*(Exp[-h1*1/4*(n - 1)] - Exp[-h1*1/4*n]), {n, 1, 4}]
&&
Sum[77/10000*1/4*1/4*n*97/100*Exp[-h1*1/4*n], {n, 1, 4}] +
Sum[77/10000*1/4*1/4*n*94/100*Exp[-h2*1/4*n], {n, 5, 8}] -
Sum[1/2*1/4*n*97/100*(Exp[-h1*1/4*(n - 1)] - Exp[-h1*1/4*n]), {n, 1, 4}] +
Sum[1/2*1/4*n*94/100*(Exp[-h1*1/4*(n - 1)] - Exp[-h2*1/4*n]), {n, 5}] +
Sum[1/2*1/4*n*94/100*(Exp[-h2*1/4*(n - 1)] - Exp[-h2*1/4*n]), {n, 6,8}],
{h1, h2}, Reals]'

I get following output but doesn't give values of h1 and h2 which will minimize the expression. I get h1 = 0.01148 and h2 = 0.01451 when I use goal seek in excel. Can anybody help in trouble shooting the issue in Minimize function
Minimize[(97 E^-h1)/80000 + (291 E^(-3 h1/4))/320000 + (97 E^(-h1/2))/
160000 + (97 E^(-h1/4))/320000 - 97/200 (-E^-h1 + E^(-3 h1/4)) -
291/800 (-E^(-3 h1/4) + E^(-h1/2)) - 97/800 (1 - E^(-h1/4)) -
97/400 (-E^(-h1/2) + E^(-h1/4)) && (7469 E^-h1)/4000000 + (
22407 E^(-3 h1/4))/16000000 + (7469 E^(-h1/2))/8000000 + (
7469 E^(-h1/4))/16000000 + (3619 E^(-2 h2))/1000000 + (
25333 E^(-7 h2/4))/8000000 + (10857 E^(-3 h2/2))/4000000 + (
3619 E^(-5 h2/4))/1600000 - 97/200 (-E^-h1 + E^(-3 h1/4)) -
291/800 (-E^(-3 h1/4) + E^(-h1/2)) - 97/800 (1 - E^(-h1/4)) -
97/400 (-E^(-h1/2) + E^(-h1/4)) + 47/50 (-E^(-2 h2) + E^(-7 h2/4)) +
329/400 (-E^(-7 h2/4) + E^(-3 h2/2)) + 47/80 (E^-h1 - E^(-5 h2/4)) +
141/200 (-E^(-3 h2/2) + E^(-5 h2/4)) + 47/100 (E^(-3 h1/4) - E^-h2) +
141/400 (E^(-h1/2) - E^(-3 h2/4)) + 47/200 (E^(-h1/4) - E^(-h2/2)) +
47/400 (1 - E^(-h2/4)), {h1, h2}, Reals]

A: expr1 = Sum[50/10000*1/4*1/4*n*97/100*Exp[-h1*1/4*n], {n, 1, 4}] -
   Sum[1/2*1/4*n*97/100*(Exp[-h1*1/4*(n - 1)] - Exp[-h1*1/4*n]), {n, 1, 4}];

expr2 = Sum[77/10000*1/4*1/4*n*97/100*Exp[-h1*1/4*n], {n, 1, 4}] +
   Sum[77/10000*1/4*1/4*n*94/100*Exp[-h2*1/4*n], {n, 5, 8}] -
   Sum[1/2*1/4*n*97/100*(Exp[-h1*1/4*(n - 1)] - Exp[-h1*1/4*n]), {n, 1, 4}] +
   Sum[1/2*1/4*n*94/100*(Exp[-h1*1/4*(n - 1)] - Exp[-h2*1/4*n]), {n, 5}] +
   Sum[1/2*1/4*n*94/100*(Exp[-h2*1/4*(n - 1)] - Exp[-h2*1/4*n]), {n, 6, 8}];

Plot3D[{expr1, expr2}, {h1, -5, 5}, {h2, -5, 5}, ClippingStyle -> None,
 PlotLegends -> "Expressions"]

You must minimize some function of the two expressions
NMinimize[#, {h1, h2}] & /@
 {Abs[expr1*expr2], Abs[expr1 + expr2],
  expr1^2 + expr2^2}

You may also wish to constrain the region of interest.
NMinimize[{expr1^2 + expr2^2, h1 >= 0, h2 >= 0}, {h1, h2}]

EDIT: Your comment below indicates that you desire both expressions to be zero
NSolve[{expr1 == 0, expr2 == 0}, {h1, h2}, Reals]

{{h1 -> 0.00998752, h2 -> -0.000767111}}


text:
Józef Korneliusz O'Rourke (ur. 1772 w Dorpacie, zm. 1849 w majątku Wsielub) – rosyjski wojskowy i polityk, dowódca wojskowy okresu wojen napoleońskich.

Józef Korneliusz urodził się w 1772. Wstąpił do armii Imperium Rosyjskiego i jego pierwszą akcją militarną był udział w drugiej bitwie o Zurych przeciwko armii francuskiej. Później O'Rourke stworzył i wyekwipował swój prywatny pułk i udał się do Serbii, by walczyć tam przeciw Turkom. Decydujące zwycięstwo odniósł pod Warwarinem.

O'Rourke zakończył karierę wojskową w stopniu generała dywizji. Osiadł w swoim majątku Wsielub niedaleko Nowogródka i zmarł w 1849.

Był żonaty z Amelią Piławską, córką Felicjana, ostatniego starosty Łucka. Najstarszym jego synem był Aleksander Patryk, a wnukiem Karol Marian O'Rourke. Najmłodszym synem był Michał Łazarz, którego synem był późniejszy biskup gdański Edward O'Rourke.

Linki zewnętrzne
 Biografia z 1910 (en)
  (en)

O'Rourke, Józef Korneliusz
O'Rourke, Józef Korneliusz
O'Rourke, Józef Korneliusz

redpajama_set_name: RedPajamaWikipedia


Get a lot more interviews and kick start a new career. 2 how does one use the sqlloader utility. Oracle 10g is the release for automation and advisors.
In this tutorial you will use sql developer to create objects for a simplified library database which will include tables for books patrons people who have library cards and transactions checking a book out returning a book and so on.
Sample resume for oracle pl sql developer. List the right sql experience with the best sql skills and achievements. Be sure to check out our faq and read through the community guidelines. Best resume for database developer you can download easily career objective to get a challenging position where i can put my all experience and knowledge to give a significant. If part or all of the result of a select statement is equivalent to an existing materialized view then oracle database may use the materialized view in place of one or more tables specified in the.
New to oracle community. There are lot of opportunities from many reputed companies in the world. Then join our getting started group introduce yourself to community and start exploring. This article introduces the new merge sql command sometimes referred to as upsert.
Expertise in sql and plsql programming developing complex code units. 1 what is sqlloader and what is it used for. An sql developer resume sample that gets jobs. Sql tuning advisor in 10g.
6solid experience of creating plsql packages procedures functions triggers views and exception handling for retrieving manipulating checking and migrating complex data sets in oracle. Use a select statement or subquery to retrieve data from one or more tables object tables views object views or materialized views. Merge is a dml command that enables us to optionally update or insert data into a target table depending on whether matching records already exist. 3 how does one load ms excel data into oracle.
The merge statement in oracle 9i. Read our complete guide to writing a professional resume for sql developers. 4 is there a sqlunloader to download data to a flat file. Oracle has introduced several new advisors which will make numerous recommendations on how to streamline everything from sga configuration to individual sql statements.
Get 20 great examples and job winning tips from our experts. If youre looking for oracle pl sql interview questions for experienced or freshers you are at right place.


Risk Management: Is Your Club Compliant or Complacent?
As a fitness manager, you recognize that certain acts result in legal liability. Injuries caused by worn flooring surfaces, equipment malfunctions and inappropriate program designs exemplify what acts have legal consequences. However, the critical issue is who may be legally responsible for injuries. If one of your personal fitness trainers designs an inappropriate program for a client and that client is injured, who is liable—you or the trainer?
Is it possible to view past issues of the newsletters?


Large-scale design proposed for office building lobby. See also Mechanical Botanical in Portfolios.
Photographic assemblage combining photographs and photograms from various series, including Little Rituals. Dimensions variable.
Design for environmental structure. Dimensions variable.
Photographic assemblage combining images from Little Rituals and Extrapolations. Dimensions variable.
Still from Digital Animation created for PECO's Crown Lights "Art in the Air" program. Digital Animation by Andrew Stuber.
Digital Animation created for PECO's Crown Lights "Art in the Air" program. Digital Animation by Andrew Stuber.
Examples of completed and proposed projects utilizing my photographic imagery in large scale, site-specific public and private works. My largest project to date, Dreams in Transit, is a 10-foot by 30-foot photographic mural commissioned by New Jersey Transit, for the 9th Street Station in Hoboken, New Jersey. The permanent installation, completed in 2004, is fabricated in porcelain enamel on steel, and combines images from Little Rituals with photograms as well as photographs made in the surrounding area.


Product prices and availability are accurate as of 2019-04-19 02:32:58 UTC and are subject to change. Any price and availability information displayed on http://www.amazon.com/ at the time of purchase will apply to the purchase of this product.
You don't like beer. You love it. That sublime pour. That first frothy sip. Now you want to experiment with brewing beer batches at home, and there are plenty of books out there for the curious and eager DIY-er. But other homebrew titles give exhaustive historical accounts and complicated technical details about the science of brewing beer.
You don't need all the science. You need simple, no-fuss instructions to nailing that perfect homebrew.
Enter: DIY Beer Brewing. Featuring simple, step-by-step instructions for first-time home brewers, it's never been easier to prepare tasty batches.


Running through the Storms: Happy Love Day!
I love this happy, sappy, Hallmark Holiday! I love pink and red..
On this day, I dedicate this post to the one my heart loves..
" I love you" is not enough to describe the way I feel for him. I can't put it into words, on paper, express it enough, buy enough, show him enough, how much I really love him.
We are extremely blessed and thankful to have found one another. Most people search their entire life and don't find the love that we have. We could spend every hour, of every day together and I still wouldn't get sick of him.
I am amazed by his generosity, loving heart and kind spirit. He is a great leader, provider, protector and my personal space heater. Every single day, I am reminded why I chose to spend the rest of my life with him. I am thankful for Gods blessing on our life and marriage.
I look forward to many more Valentines together! I love you more and more everday!
Aw! Happy Valentine's Day! We never get sick of each other either!
I live in Michigan! Happy Valentines Day!!! Hope you are having a blessed day and feeling very loved!


text:
Restaurants' patios now a big part of their business equation after COVID shifted dining outdoors — permanently
Food // Restaurants
Paul Stephen, Staff writer
May 12, 2022 Updated: May 12, 2022 10:19 a.m.
Customers dine on the patio at Jardín.
This spring has brought record-high temperatures to San Antonio, a scorching climactic occurrence that, in years past, would have sent restaurant customers scurrying indoors into the icy embrace of air conditioning. But so far, restaurateurs across the city are finding their patio seating in far higher demand than ever.
Before the pandemic, patios were seen as a nice bonus option that might draw some business for a few months out of the year. But when there were strict occupancy limits for indoor dining rooms and customers were feeling more comfortable eating outdoors than inside, restaurant owners added patios or started beefing up the ones they had with more tables and better cooling and heating systems.
Maybe it's a case of if you build it, they will come, but now you can find diners parked at an outdoor table at nearly any date on the calendar, and owners see patio dining as a permanent, year-round part of their business.
That's led owners to invest even more heavily in improvements for their al fresco spots, and if you're a property owner, good luck leasing it to a restaurateur if there isn't some kind of outdoor space available.
On ExpressNews.com: 11 great San Antonio restaurant patios for a perfect al fresco dining experience
Restaurateur Jason Dady owns several properties with ample outdoor seating including Two Bros. BBQ Market, Alamo BBQ Co., Tre Trattoria and Jardín. When restaurants began reopening in 2020, Dady's patio spaces provided a lifeline to his restaurant empire. And it's one of the reasons he was able to survive when so many other eateries shuttered for good.
"The only reason we came out ahead was because of those outdoor spaces," Dady said. "I think we had a major advantage over people who didn't have an outdoor option. It's just that simple."
Dady estimated that prior to the pandemic, his indoor and outdoor clientele was skewed roughly 70 percent indoors and 30 percent out. Now, he said, the balance is much closer to 50/50, and it's made him double down on making those outdoor spaces inviting — and profitable.
In addition to burning through more and more umbrellas and bug-repelling fans that wear out rapidly, he's made several significant investments including an additional $15,000 worth of tables and chairs at Jardín and a new $40,000 covered patio at Two Bros. that will allow him to seat an additional 100 customers.
"I think this became a way of our world for the past two years, and it isn't going anywhere," he said.
Bombay Bicycle Club general manager Ali Berrera (center) serves a plate of nachos to members of Trinity University's women's basketball team.
Paul Stephen / StaffShow MoreShow Less
Improvements to Bombay Bicycle Club's back patio will include a server station and outdoor bar.
Alison Martinez serves a group of family and friends celebrating a birthday at Guillermo's Austin Street on Wednesday evening.
KAYLEE C GREENLEE BEAL 2022Show MoreShow Less
Vivian and Jose Hernandez share a burger, fries and a salad at Guillermo's Austin Street on Wednesday evening.
Alex Hernandez and Celeste Alvarez talk over drinks at Guillermo's Austin Street on Wednesday evening.
National numbers support that thought. The National Restaurant Association's 2021 State of the Restaurant Industry report indicated that since the start of the pandemic, 62 percent of fine dining and 56 percent of casual dining restaurant owners have committed more resources to expanding and developing their outdoor dining spaces, 45 percent of both casual and fine dining operators said they've added seating to their parking lots and sidewalks. The vast majority of operators surveyed said they plan on keeping those outdoor improvements in place.
Not all properties are created equal when it comes to patios. Jeremy Rushing, an agent with Restaurant Realty Group, said there's a sweet spot.
"People want 1,500 to 2,000 square feet with a drive-thru and a patio. Those are getting snatched up almost before they even hit the market," Rushing said. "There's not enough inventory anywhere. Austin is pretty much tapped out and San Antonio is following close behind."
The outdoor patio at Guillermo's Austin Street can seat at least 200 customers.
Josie Norris / San Antonio Express-News
"In San Antonio's prime downtown areas, I can think of a handful that are available," he said. San Antonio may be near patio saturation.
At The Hayden, which opened on Broadway near Brackenridge Park in late 2020, owner Adam Lampinstein knew he'd be busy for Mother's Day. What he didn't expect was just how many customers would choose to sit outside — even well into the afternoon when temperatures spiked to nearly 100 degrees.
"Mother's Day was crazy busy, and we were full of reservations. We set up a bunch of extra tables assuming nobody would want to sit outside after 10 a.m., but they were out there all day," Lampinstein said. "But Texas people know it's going to be hot, and we're OK with it. If you live here you know what you're getting into."
On ExpressNews.com: The 4 best San Antonio rooftop bars with great skyline views
At the Hayden, Lampinstein's patio has a charming view of a tree-lined courtyard shared with the nearby Press Coffee. It remains breezy thanks to the addition of several industrial-grade fans — an upgrade from cheaper fans he found burnt out too quickly. He's made several other functional and cosmetic improvements to the space to keep customers comfortable, as well.
Lampinstein places a small, portable insect-repellent fan on each table to keep the flies and mosquitoes away. The section often has a dedicated server who keeps food and drink moving at a quicker pace. And he's invested in hand-held point-of-sale devices that prevent the time-consuming dance of waiting for the server to run inside, swipe a card and return with the bill.
Those efficiencies are matched with aesthetics. Lampinstein recently purchased string lights and lush plants to make the space even more inviting.
"I think it's up to the restaurant owner to make the outdoor space not an afterthought," he said. "You try to make the outdoor space as much like indoors as possible."
Family and friends celebrate a birthday at Guillermo's Austin Street on Wednesday evening.
KAYLEE C GREENLEE BEAL 2022
On a recent 95-degree afternoon, nearly every seat was packed on the side patio at the Bombay Bicycle Club on North St. Mary's Street as the Trinity University women's basketball team packed the space to celebrate a triumphant 28-3 season. There was still room for another 50 patrons on a back patio that owner Bill Leighton added to the property as the pandemic hit full steam in June 2020, but that space is closed for a few weeks for renovations. The new patio has been such a hit that Leighton is adding a server station and outdoor bar with a selection of draft beers.
Not bad for a converted parking lot.
"It took off pretty much immediately," Bombay general manager Ali Barrera said. "We laid down artificial turf, which helps keep the patio cooler. We lost about seven or eight parking spaces, but it was more than a fair trade."
Guillermo Garza, owner of the popular Guillermo's restaurant on McCullough downtown scooped up an Austin Street home near Government Hill before the pandemic hit with the intention of turning it into a ghost kitchen. But when he saw how COVID was driving demand for outdoor dining, he changed gears and decide to make it a second Guillermo's location complete with a new sprawling, customer-friendly courtyard.
On ExpressNews.com: The 5 best panaderías, Mexican bakeries, on San Antonio's South Side and downtown
"When COVID hit, I realized we can really do something with this outdoor space," Garza said.
The tiny indoor space at the new Guillermo's can seat about 25, but Garza can seat more than 200 customers in the courtyard, which is equipped with fans and complimentary bug spray in addition to a full second bar to keep plenty of cold beer flowing.
He said he hasn't had any trouble keeping customers happy, even when temperatures spike.
"These first two 100-degree days, I'm looking at the reports, and my manager said everyone still wants to sit outside," Garza said. "Fortunately we have some really great patio spaces that regardless of where the sun's at, you're in the right position to feel the wind coming in from the southeast."
Members of Trinity University's women's basketball team celebrate their winning season on the patio at Bombay Bicycle Club.
Paul Stephen / Staff
The boom in outdoor dining has led to a few unexpected operational challenges. At The Hayden, Lampinstein now spends more than twice what he used to on ice. His one ice maker struggles to keep up with demand as margaritas and glasses of water sweat away outside, so he's having to buy supplemental ice from a supplier and may soon add a second ice maker to keep up.
For restaurateur Dady, just making sure everyone has a seat has proven difficult on some days.
"The trickiest part of it is managing the reservations," Dady said. "On a busy Saturday, we might have 200 reservations on the patio And if it rains, we don't have anywhere to seat you inside because all those tables are booked as well. It's important to have very good communication with customers about their reservations."
pstephen@express-news.net | Twitter: @pjbites | Instagram: @pjstephen
Paul Stephen
Paul Stephen moved to San Antonio from North Carolina in 2017 to join the Express-News Taste team. In that time, he's cooked through about 1,000 recipes, noshed at more than 200 restaurants and seriously considered getting a map of the city's grocery stores tattooed on his arm for easy reference. He cannot be trusted around your cookbook collection.


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Around SA
I wish all our residents a blessed, joyous, and peaceful festive season
With the arrival of the festive season, comes an opportunity for all of us to reflect on the year that has been 2017.
For me, it has brought with it the chance to make a difference in the lives of others.
In my role as the Mayor for the City of Johannesburg, I had the opportunity to see communities get greater access to health care through the implementation of extended operating hours at clinics; seen 3672 title deeds given to residents who have never known the joy and dignity of owning a home; witnessed residents take ownership of their communities by helping to clean the city through the A Re Sebetseng clean-up campaign; and have felt in immense pride in seeing 1500 residents enter the City's service as new JMPD trainee officers, who will help to keep our cities safe in the not so distant future.
Despite all this, there is still much to be done in order to bring improved service delivery to our residents throughout the City. I remain up to that challenge.
I would ask that we spare a thought or a prayer for those less fortunate than us, and where possible, that we give back to our communities in whatever little way we can.
Finally, whatever you may choose to do, or wherever you may choose to visit during this festive season, please keep safe, especially on our roads.
I wish all our residents a blessed, joyous, and peaceful festive season.
Inner City Gazette TV
Sithembile Moyo
Editor: Sithembile Moyo
Email: editor@inner-city-gazette.com
The inner-city Gazette The inner-city Gazette is a Unique Community Newspaper .Most Newspapers are owned by millionaires and reflects the outlook of the rich and powerful. The Inner-city Gazette is produced by Gazette Media and gives the Inner-city Residents a point of view on the big issues in their community, politics and the world. The primary target audience is the residents and the business community in the Inner-city. The Newspaper is both a forum for debate and a source of information for the Inner-city Resident.
Find us on Issuu: https://rb.gy/nhdhmi
© 2021 Inner City Gazette


I found that, contrary to judicial and scholarly assumptions, qualified immunity is rarely the formal reason that civil rights damages actions against law enforcement end.
Although courts rarely dismiss Section 1983 suits against law enforcement on qualified immunity grounds, there is every reason to believe that qualified immunity doctrine influences the litigation of Section 1983 claims in other ways.
One should not conclude based on my findings that the Supreme Court simply needs to make qualified immunity stronger.
Diplomatic immunity to protect diplomats from being prosecuted for violating U.
Prosecutors and investigators generally offer immunity when a witness can help them prove a case.
What Does Immunity From Prosecution Mean?
It cannot be simply assumed that he will invoke it since the privilege of presidential immunity belongs solely to him and is exclusively his prerogative.
In a separate memorandum, De Lima also asked the court to immediately grant her appeal for the writ of habeas data while deferring its ruling on his presidential immunity until he actually invoked it.
Waivers of immunity also differ in scope with regard to what types of claims are permitted.
Most states have adopted the "discretionary function" exception in some fashion, and have limited the waiver of immunity to only those claims involving operational decisions.
In lieu of a broad waiver and accompanying list of exceptions, some jurisdictions have instead set forth waivers of immunity that are claim specific.


text:
Hero of Nation Chandra Shekhar Azad is a 2022 Hindi film starring Ahmad Kabir Shadan, Riitu Sood, Raza Murad, and Zarina Wahab.

Plot
The film is based on Chandra Shekhar Azad's life. The film  will introduce us to Azad's life like his family ties union with freedom fighters as well as the personality.

Cast
 Ahmad Kabir Shadan as Chandra Shekhar Azad
 Riitu Sood as Durga Bhabhi
 Raza Murad  as Sitaram Tiwari father of Azad
 Zarina Wahab as Jagraani Devi mother of Azad
 Puneet Agarwal as Vishwanath
 Kavita Thakur as Rudranarayan wife

References

External links

 Hero of Nation Chandra Shekhar Azad (2022) - Review, Star Cast, News, Photos
 Hero of Nation Chandra Shekhar Azad (2022) | Hero of Nation Chandra Shekhar Azad Movie | Hero of Nation Chandra Shekhar Azad Bollywood Movie Cast & Crew, Release Date, Review, Photos, Videos
 Hero of Nation Chandra Shekhar Azad

2022 films
2022 biographical drama films
Indian drama films
2020s Hindi-language films
Indian biographical drama films


Description: With 2-1/4" x 2-13/16" Mounting Centers. The original 120V version! The classic! Great paper layer wound power transformer like originals! The basic 120V Deluxe** type amp power transformer used from the '60s until the modern era. A Best Value Power Transformer!!!


Many of us stay with the same bank for decades, without considering whether we've made the right choice. The same is true with accountants, where clients often remain loyal for long periods, which is great if you're getting what you want and work well together. Sometimes though, people have reasons for wanting to change but don't, being concerned about the risk or hassle that might be involved. It's not as hard as it's perceived to be though and here's an insight into what's involved.
If you've decided to change, the first order of business is to find yourself a new accountant! You will also need to notify your existing accountant of the change, giving your consent to release your records and share information. Your new accountant can often provide a simple pro forma letter you can use for this, should you need one.
There are a couple of straight forward formalities that you'll need to go through with the new accountant. The main one is that all accountants are legally obliged to undertake some simple checks before taking on new clients and you may well be asked to provide current proof of your identify and address. This is part of the accountant's responsibility to help HMRC combat fraud and illegal money laundering but it's nothing to be concerned about.
The good news is that your new accountant and the previous one will generally manage the handover between themselves. If your existing accountant belongs to a chartered body or is otherwise professionally qualified, they will be duty bound to fully support the handover within a reasonable timeframe, in the best interests of the client.
Your new accountant will write to your previous accountant to ask for "Professional Clearance", which involves providing information and documents to ensure a smooth handover. Typically, this will include things like the latest accounts and returns, breakdown of assets, tax computations and details of any outstanding issues with HMRC. It is very unusual for your existing accountant to charge you for handing over, since it should not take long to compile the information and documents from their files. They could charge a small fee for about an hour of their time but, in practice, very few accountants do this.
Following "Professional Clearance", you will normally be asked to agree and sign a "Letter of Engagement" from your new accountant. This defines the scope of work and everyone's responsibilities. It can look detailed but it's not especially onerous and makes sure everything is clear up front.
The most common problem is a dispute with your existing accountant, where they charge you a fee you don't think is appropriate and they want it resolved prior to handover. If they belong to a chartered body they should not refuse "Professional Clearance" on the basis of a fee dispute alone, although they are entitled to advise your new accountant of the circumstances. Your new accountant may be able to assist in resolving the problem.
Another problem may be that your existing accountant does not respond, although this would be very unusual from a member of a chartered body. This could occur if they are no longer in business, are unqualified or simply refuse to answer correspondence. If this happens then your new accountant must make a reasonable attempt to contact them and obtain a response. If all else fails then it can be inconvenient but, for a small business, it's unlikely to be a significant problem.
It's in everyone's interests that the handover runs smoothly, including the outgoing accountant. Although no-one likes to lose a client it's just part of being in business and accountants do value their professional reputation. Professional bodies also have ethical guidelines and rules in place to make sure this happens. It's generally much easier than you think!


text:
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text:
Bluegrass Champs
Bluegrass Bands
IBMA Awards History
Jam Camps
Download Shop
Sell Swap Buy
Williamson Branch's Heritage & Hope
by Greg McGrath | 14 Jan, 2021
With 2021 now in full swing, Williamson Branch is kicking off the new year with the announcement of their upcoming two-disc project Heritage & Hope. To celebrate the release the group just unveiled two new Gospel singles. Both Walking In The Spirit featuring The Marshall Family and I'll Fly Away are available to down and stream now. Fans can expect the band's first nationally released all-Gospel collection to drop on 13th March.
On this two-volume Gospel collection, the Heritage side is filled with songs to remind us of our rich past, while the Hope side has songs to assure us of our bright future.In the 70s, the Marshall Family was the epitome of family harmony. Their anointed music strongly influenced Williamson Branch but also, the Issacs, Alison Krauss and many others. We're honoured to have them join us on Walking in The Spirit. Hearing the surviving members of the group record together for the first time since the 80s is the thrill of a lifetime – Williamson Branch.
On the new collection, Heritage and Hope offers two themes throughout. With one disc focusing on Hope, they are a group of songs that offer an optimistic and inspirational approach (Walking In The Spirit). On the other end, Heritage serves as the other disc's motivation, featuring recordings that are already well-known to most church-goers (I'll Fly Away). In total, the project includes a grand total of 23 tracks, and will take listeners on an emotional ride by reminding fans what life is all about.
Walking In The Spirit is an original tune that sees the award-winning band teaming up with legendary family group The Marshall Family, who have turned heads in countless Southern Gospel, Bluegrass and Traditional Gospel circles over the years. The song was written by Angeline Marshall and includes blends of multiple genres of music throughout. Singing lead on the track is current International Bluegrass Music Association (IBMA) Momentum Award recipient Melody Williamson who recently took home Vocalist of the Year.
Perhaps the leading inspiration behind the project is from the fan-favorite I'll Fly Away. Previously, the band released a live performance of the track, and it struck like wildfire, going on to amass over 15 million views to date. For the first time ever, fans can now download and stream a full studio-recording of the song. After partnering with the Country Rebel network, the version struck a chord with viewers, by going on to get hundreds of thousands of shares and introduce the band to a massive audience. The song features the band trading off lines, while also showcasing the tight harmonies and powerful vocals of sisters Melody, Kadence and Caroline Williamson.
While 2020 was a tough year in many aspects, Williamson Branch was able to grow their online following and shatter glass ceilings. When the COVID-19 restrictions first started, the group took to their official FB page to entertain and encourage fans. They did just that by creating unique content that showcased each member's fun-loving personality, combined with their show-stopping performances. They also created a unique / inspirational twist by also taking prayer requests and a quick daily devotional led by Kevin Williamson. After consistently connecting with fans of all ages, Williamson Branch was able to grow their page to over 400K followers currently.
To keep up with all things Williamson Branch check out their:
Official FB page or
Casey Penn – We Go Together Like a Guitar and a Fiddle
I Know He'll Let Me In – The Churchmen
Route 3 – Losing Time
Living In The South – Starlett & Big John
Jamie Johnson Rejoins The Grascals
Karma – Volume Five
Walk On Faith – The King James Boys
Bluegrass Standard Jan 2023
Australian Bluegrass News
IBMA News
Ask Ozzie
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Bellbird Banjos
Cargill Custom Guitars
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Thanks for coming to our ccna mcse information and resources page. We know your time is valuable and we hope that we can add some valuable insight on the subject of ccna mcse for you. Growing up in Los Angeles, I was able to learn a great deal about many different things. I was also able to meet very itelligent people who were at the forefront of technology. I am not sure what this has to do with your search, so let's get back to that. It doesn't matter whether or not you think the Swift Boat Veterans are providing a positive influence on the election. We are here to talk about ccna mcse. Maybe the idea of a two-mile jog every day in tropical heat isn't your cup of tea. It doesn't matter to us. We know you are just trying to find some information. So, let us help you find what you are looking for. Enjoy our ccna mcse resources and be sure to check in with us soon as this page receives frequent updates to its content. Enjoy.


text:
Phase 3 Trial of Fenfluramine for Lennox-Gastaut Syndrome Completes Enrollment
Enrollment of 263 individuals with Lennox-Gastaut syndrome (LGS) has been completed for a phase 3 clinical (NCT03355209) trial of fenfluramine (Fintepla; Zogenix, Emeryville, CA). The primary outcome measure is decreased seizure frequency compared to a baseline measured during prerandomization and titration phases of the study.
"We have been extremely pleased with the rate of enrollment in this trial and look forward to the availability of top-line safety and efficacy data in the first quarter of 2020," said Gail M. Farfel, PhD, executive vice president and chief development officer, Zogenix. "Based on the compelling data generated in the previously completed Phase 2 study, we believe this promising drug candidate has the potential to become an important new treatment option for the control of seizures in patients suffering from LGS."
The study is a double-blind, placebo-controlled trial of 2 fixed doses of fenfluramine as adjunctive therapy for seizures in children and adults with LGS. After a 4-week observation period to establish baseline seizure frequency, participants are randomly assigned to receive a starting dose of 0.2 mg/kg/day or 0.8 mg/kg/day or placebo. Dose titration occurs over 4 weeks to a maximum of 30 mg/day of fenfluramine and is followed by 12 weeks of maintenance treatment at the titrated dose.
Participants who complete the maintenance treatment portion of the study may be eligible to enter a 12-month, open-label extension to evaluate the long-term safety, tolerability, and effectiveness of fenfluramine for LGS.
Risdiplam—a Potential Oral Treatment for Spinal Muscle Atrophy in Clinical Trials Expanded and Recruiting Globally
Blood Biomarkers May Help to Predict Length of Recovery Time from Concussion
Epilepsy Essentials: Chronobiology of Epilepsy
Michelle L. Dougherty, MD, FAAN


A 100% guaranteed bet that will give you a 14-25% ROI.
I have never given a specific bet on this website. Never have I said take the Swans at -20 at odds of 1.90. The reason is that no bet ever is a certainty (unless it's fixed). You can do all the research, have all the value and still lose. But what I am about to tell you now is a sure thing and if you are in this situation you would be an idiot not to do it.
Below is my ironclad guarantee. No other amount of money you ever place on anything will give you a return of between 14-25% risk free. I would give my right arm for a return on investment of just 5%. This simple thing which will take you mere seconds to do will give you an amazing return.
PAY YOUR CREDIT CARD BILL BEFORE EVER PLACING A BET.
If you have any sort of credit card debt you should not be betting. Let's say you have the Australian average of about $5,000 of credit card debt. At an 18% interest rate you are paying $900 a year in interest rates. That's the same as placing $5,000 on a 1.20 shot and walking away knowing you have already won. It's simple really and if your not smart enough to see that then your not only going to be a long term loser when it comes to gambler, but also a long term loser in life.
$20,395 profit in 1 day.
Steve, just read this "words of wisdom" post from the past. Never a truer word spoken! It's dollars looking after themselves.. blah blah blah. Just as taking advantage of promotional bets with the Aust books (who allow me – or my partner, sister, parents…. ha ha). What's not to like about monetising a risk free 25 bucks for a few click of the mouse? Economist say there is no such thing as money lying on the ground, as they assume someone would have already picked it up, but it's not the case with sports betting!


Alpha Index Module - Ideal Extensions for Joomla!
Contact Enhanced Alpha Index Module, also known as Alphabetical Search, displays Alphabetic seach links. It will filter contacts starting with the respective letter.
Select add a new module and choose Contact Enhanced Alpha Index module!


PowerMags will transform the way you use magnets. These versatile, high-performance neodymium magnets can be used to make invisible magnetic catches, as well as hold anything and everything metal. Get creative!
Holey PowerMags feature holes to accommodate a screw for attaching the magnet to your surface. The magnets are countersunk for 3/8" PowerHead Screws.