text:
PALCULATION
We're treating friendships like transactions, and it's ruining relationships
EPA/Sanjeev Gupta
"Some people go to priests; others to poetry I to my friends."
By Ephrat Livni
Senior reporter, law & politics, DC.
August 10, 2018 This article is more than 2 years old.
How are your friendship metrics—got lots of pals? Would you rate them five stars or less? Are they helping you live your best life?
We can quantify everything now—from our steps on Fitbit to our literary consumption on Goodreads. As a result, we feel we must make everything and everyone count for something. That's a phenomenon which is both distressing and depressing as it applies to friendship.
Scan the internet and you'll see no end of posts advising you to toss toxic friends and surround yourself with people who make you feel good instead. The current cultural discourse suggests that friends are people who we use to improve ourselves, and get rid of when the going gets tough or if we're not having enough fun. One BuzzFeed article goes so far as to suggest forgetting a birthday is a dump-worthy offense, while a Cosmopolitan article recommends tossing friends who binge-drink on a Saturday night.
The way we talk about friendship paints an ugly picture of the new notion of relating—one that seeks maximum return on minimal investment, and outlines an exit strategy anytime a friend doesn't fulfill our fantasies. These posts reveal more about the toxicity of our society than the negative people they're describing. It's friendship as a capitalistic exchange, instead of relationships involving people who care about each other, hanging out, and helping each other through life's ups and downs.
It's enough to make you want to cry into a beer with a confidante—you know, a close friend of the kind that's going out of style.
Transacting relationships
Take, for example, a recent New York Times article about "the power of positive people" (paywall), which asks, "Are your friendships giving you a boost or bringing you down?" In it, Tara Parker-Pope, just back from a wellness cruise filled with upbeat personalities, advises readers to be mindful of their relationships for the sake of a long life. "Buoyed by the experience, I returned home with a renewed commitment not only to exercise and healthful living, but to simply step up my social life and spend more time hanging out with happy people," she writes.
Pity her pals. Let's hope none of them are struggling, sad, or in need of a friend, because it seems she'll be preoccupied trying to find more positive people. "While many of us focus primarily on diet and exercise to achieve better health, science suggests that our well-being also is influenced by the company we keep," she writes. The article advises choosing friends wisely for how they improve heath and directs readers to a quiz about "optimizing" friendships.
The Blue Zones quiz—a reference to blue zones of the world where people seem to live longer—measures your health and longevity and that of three close associates with questions about exercise, weight, diet, smoking, drinking, and mood, providing a numerical score (of course!) for you and your buddies. "Research shows that friends can have a long-term impact on our health. In fact, if your best friends are obese, you're about twice as likely to be overweight," the site explains. Under the logic of the quiz, if your friends have a streak of bad days, smoke cigarettes, loathe jogging, or have a weakness for pastries, they're actually dragging you down.
You can find advice on toxic friendships pretty much everywhere else on the internet, too. HuffPo warns that bad pals are smart, stubborn, fussy, harsh, and pessimistic, to name just a few of their negative traits. Presumably the takeaway is that a healthy friend is a stupid pushover with no standards who sees the glass (with a non-alcoholic beverage) as half-full, always, and won't acknowledge any feeling but optimism.
Business Insider says toxic people do inappropriate things, like show up at your house uninvited and unannounced. They're needy, make you feel responsible for them, and copy you. Instead, seek friends who find you uninspiring, never inconvenience you, follow strict social rules even in an emergency, and have no sense of protectiveness.
What friends are for
Most notably, the focus of all these posts is on you, not your friends. This contradicts the basic premise of friendship, and is therefore problematic. These writers don't ask what you might do for your friends, or to consider why they are suffering and struggling. Instead, they urge you to consider what people can do for you, explaining why you should abandon those who don't provide.
But real friendship is a kind of love, writes philosopher Bennet Helm. As such, it must "involve a concern for your friend for his sake and not for your own," Helm explains.
There is a solid argument for breaking up with friends who repeatedly betray your trust and hurt your feelings, as Quartz's Olivia Goldhill notes. But it's worth recalling that true friendship, unlike an accumulation of abstract quantifiable ties online, is full of ups and downs. As advice columnist Heather Havrilesky wrote to a reader asking whether to dump a toxic friend, "if you want to know interesting, intense people — and I know I do — you're going to discover that a LOT of them are also careless and confused and ruled by shame." Everyone, Havrilesky explains, is a difficult person once you get to know them.
Friendship isn't easy and it was never meant to be, which is why people didn't used to collect friends or quantify them as we do now. The essayist William Deresiewicz notes in the Chronicle of Higher Education, "The idea of friendship in ancient times could not have been more different. Achilles and Patroclus, David and Jonathan, Virgil's Nisus and Euryalus: Far from being ordinary and universal, friendship, for the ancients, was rare, precious, and hard-won."
A true friend didn't just flatter and please. Quite the contrary, their value lay in the fact that they sometimes corrected or fought with their pals, to whom they'd give their all.
Deresiewicz notes that Shakespeare respected these ancient friendships. That's why Hamlet's most trusted friend Horatio, who was willing to drink poison intended for the prince, says he is "more an antique Roman than a Dane." Their connection ran deep. A real companion, unlike the fickle buffoons Rosencrantz and Gildenstern, Horatio criticized Hamlet, kept his secrets, tolerated his madness, and didn't begrudge his antics or neediness. Horatio didn't abandon Hamlet when he was down.
When you're sour is when your friends really count, after all, and their help is most needed. Good friends accept each other's weaknesses, cheerfully or not. They deal with our flaws, but also occasionally criticize us when that's what we need to hear to snap out of a rut or destructive slump. They don't just make us feel good—sometimes they push us around a bit by crossing boundaries.
Friends are precisely those people who show up unannounced when you're down and convince you to go out, or call at all hours and initiate impromptu philosophical talks on dark matters. They have drinks and gossip to blow off steam, or eat greasy fries at a diner during the wee hours, laughing and analyzing all that's gone wrong. And they definitely have patience for your moody blues when you're going through a rough patch instead of asking, "Don't you have a therapist for that?"
The new notion of friendship, by contrast, encourages us to develop very tentative relationships, constantly assessing one another's value. Every friend is a potential stock to be dumped when it tanks. Perhaps that's why Deresiewicz calls ours a time of "faux friendships."
A friendship premised on the need to be surrounded by positive, exercise-loving people means that both parties have little tolerance for humanness. This friendship has a goal, and it's the pursuit of personal betterment—as if life was a wellness event for self-improving types who shirk soda, alcohol, drugs, junk food, unpleasant thoughts, and discussions of life's many difficulties. To be friends, you have to walk on eggshells and aim for high ratings, instead of getting to occasionally relax in a safe space, knowing there's someone you can rely on in rough times.
Would you buy this product?
Our capitalistic thinking about friendship has gone so far that some people are starting to think of themselves as products. In GQ, writer Clay Skipper describes the wake-up call he received after receiving what he felt was a low score as a passenger on the Uber ride-sharing app. Determined to improve, he sent 40 friends, family members and exes anonymous surveys, asking them to rate his relationship skills.
Skipper created 11 categories to be rated on a scale of one to 10—including kindness, personal style, and "How Likely Are You to Recommend This Product (Me) to a Friend?" He also added a write-in option, asking "What's one thing about me that drives you nuts?" Skipper is sad to report a composite score of 7.88, which is like a C+ in terms of school grades. He is forced to conclude that in a future when we'll all be rated this way, he won't be an appealing product.
While Skipper's vulnerability is laudable, the premise of his test is horrifying. Please do not follow his lead and send one of these surveys to your friends. You are not a product or place of business subject to a Yelp! review. You are a human, though that fact may be hard to recall in this machine age.
The beauty of being human is that you are not easy to review, like a book or movie, and you're not for sale anyway. Your qualities aren't singular or fixed but ever-transitioning. You are a work in progress, light and dark, going through a process called life, which is happy and sad, good and bad, complex and fraught, not to be reduced to a ratings game or a one to 10 scale.
Friends appreciate you for reasons they can't always articulate, and love you though you may cost them time and money and wear them out on occasion."Essential and fundamental to friendship is that it is a natural, spontaneous, freely given and entered into relationship promised as much on subliminal cues that prompt liking as on anything that the parties could specify as a reason for engaging in it," writes philosopher AC Grayling in the 2013 book Friendship.
You may have shared interests, attitudes, views, taste, style, appearance, behavior, sense of humor, but much of the attraction is unconscious, Grayling posits. He cites 16th-century French philosopher Michel de Montaigne's essay "On Friendship": "If a man urge me to tell wherefore I loved him, I feel it cannot be expressed but by answering: Because it was he, because it was myself."
A pal who quantifies and weighs your relationship, calculates your contribution to their longevity and health, and judges you harshly when you're suffering isn't really a friend, then. That's just a contact and—if we must put everything in transactional terms—one that's not worth their salt.


School kids get moving more with prospect of earning rock climbing wall.
January 11, 2013 4:19 p.m.
Few indoor physical educational activities are as challenging and exciting as climbing on a rock wall. And the prospect of earning one has Oakland elementary students willing to walk the extra mile.
Students from kindergarten to sixth grade have been logging their steps since the program kicked off in late October, with a goal of running or walking a total of 5,000 miles by the end of March. The reward is a horizontal rock climbing wall, which will be installed at the school in April. The students climb across it instead of up and down, making it safer and eliminating the need for harnesses.
The challenge was presented to the entire school by Sarah Bush Lincoln's Healthy Heroes as a way to motivate kids to keep active and develop healthy habits. Part of its Healthy Kids Education program, the Healthy Hero challenge is funded though a $6,000 grant from WomenConnected, a giving circle within the SBL Health Foundation.
"It's a really great program and the kids are super excited about it," Oakland school nurse, Vivian Hudson said, adding that students logged more than 1,000 miles during its first month exceeding their goal. "Kids come up to me in the hallway all the time and tell me how many miles they walked or ran." Hudson was instrumental getting the program launched, approaching Sarah Betts, SBL Healthy Kids Educator, about ways to combat the rising rate of childhood obesity in Oakland. With rock climbing walls installed at other area schools, Betts knew it would provide an exciting reward.
With 160 kids at the school, each child has an individual goal to meet based on their grade, but in order to earn the prize, they will all have to walk or run a little more. Kindergarten and first graders were asked to log four miles per month; second and third graders, six miles per month; and fourth, fifth and sixth graders, eight miles per month. However, some of the older kids are already logging 12 miles a month, Hudson said, to put them closer to their goals. The top three students in each grade get their name added to the Wall of Fame. Those reaching their goals each month also receive a prize, including pedometers, Subway Fresh Fit Kids meals, mini Tri-County Titans footballs, team water bottles, resistance bands and jump ropes.
For more information about Sarah Bush Lincoln's Healthy Kids Education program, contact Sarah Betts, program coordinator, at 345-2860.


text:
MarketWatch: Week top personal Finance Stories
The week's top Personal Finance stories
By MarketWatch
In case you missed them, here are the top 10 Personal Finance stories from MarketWatch for the week of Jan. 25-29:
Economy forces changes in thinking about retirement homes
If your idea of a dream retirement home is a luxury contemporary overlooking a championship golf course in the desert, you better be prepared for some mighty small block parties: When it comes to retirement living, golf courses are out.
See full story.
Say goodbye to the McMansion
Times have changed, and the square footage of new American homes is dropping. Supersized homes are out, and efficiency and versatility are in. MarketWatch's Amy Hoak reports on the latest building trends.
Watch Video Report.
Many taxpayers qualify for free help and e-file software, services
How often do you see real passion when it comes to tax preparation? Meet Dr. Edward Kane, of Venice, Fla. Kane is one of over 34,000 AARP Tax-Aide volunteers. This retired orthodontist was introduced to the Tax-Aide program 17 years ago at his church in Pacific Beach, Calif.
See TaxWatch.
Three smart, simple steps to a more financially secure retirement
Bitten by the bear one too many times and uncertain about their jobs and the economy, investors have avoided stocks even after the market's rapid ascent. Indeed, the market's strong rebound over the past 10 months only makes many sidelined buyers more afraid to get on board. Their mantra: We won't get fooled again.
See Jonathan Burton's Life Savings.
Obama's proposals don't go far enough, some retirement experts say
Good, but not enough. That's how academics and advisers characterize President Barack Obama's plans to help Americans save more for retirement. Obama wants to expand tax credits that reward retirement savers, and he wants to require all employers to provide workplace-based retirement savings plans, the so-called automatic IRA.
See Robert Powell.
Much riding on stalled legislation as Obama tells Congress 'Let's get it done'
What would the proposed health-care overhaul do for regular Americans? President Barack Obama tried to answer that question and regain control of the issue in his State of the Union address Wednesday after the stunning result of last week's Massachusetts special election sunk the prospects for quick passage of a comprehensive health-care overhaul.
See Vital Signs.
The 20 cities with the highest foreclosure rates in '09
The Las Vegas metropolitan area suffered a foreclosure rate that was five times the national average and the highest rate in the country in 2009, according to a report on Thursday by RealtyTrac, an online foreclosure marketplace.
Study abroad? It will cost you, but experience is priceless
Patti Ristau said she was terrified when she first landed in Seville, Spain, for a semester studying abroad. Though the 2009 University of Wisconsin graduate had a double major that included Spanish and felt sure of herself speaking the language in Mexico and the Caribbean, Ristau, 22, was worried she would be like a taco at a tapas bar in Seville. And she was all alone.
Tips for sleep-deprived working parents
It takes a Marine to raise a baby, at least in our household. My husband, Dan, who left the service in 2004, took care of Eve's 1 a.m., 3 a.m. and 5 a.m. feedings during her first few weeks of life as I recovered from a C-section and a nasty bug caught in the hospital.
See Diary of a Recession Baby.
The new crusade against Alzheimer's
One of the truly great human accomplishments of the past century has been the revolution in longevity. People in most of the world are living longer, by far, than their forebears. That is an upheaval with profoundly positive economic consequences. But there are also some drastic downsides to the vast expansion in population.
See Marshall Loeb.
Labels: MarketWatch News

redpajama_set_name: RedPajamaCommonCrawl


I'm the Property Manager of an apartment-What should I know about testifiying at a Property Tax Appeal Trial?
One of the ways the high-end management firms support their multifamily clients is to appeal property taxes. At trial, Prime PTN will supply expert witnesses to make the actual case. Magistrate Tax court and Regular Tax Court rules of evidence require a representative from the management company to verify that rent-roll and other documents were produced by the management company. In doing so you are a "witness of fact". You may be asked very general information about the property and neighborhood. Most of this is basic property information you learned during your first couple of weeks on site as a trainee.
When do I testify? The documents you enter into evidence will start the trial. You are typically the first witness.
What documents will I be asked about? You will be asked by P-PTN if the documents entered into evidence are produced by your firm. They may include Rent Rolls, property financials, etc. They are the documents supplied by your company to us.
Will I be sworn in and asked questions? Yes. You will be asked to raise your right arm and be sworn in. P-PTN will ask you to confirm that the documents are from your firm, which they will be. We'll ask very basic questions about the property, condition, etc. The County will then be given a opportunity to question you. The scope of questions they are permitted to ask is narrow.
What if I don't know the answer to a question? The most important thing to do while testifying is to tell the truth. If the truth is that you don't know the answer…or don't understand the question, say so.
Will I have to sign in? No. Rarely you will be asked to show identification and go through a screening similar to the airport. Do not bring a weapon.
Will there be lots of people in the courtroom? No. These trials are open to the public but in practice there are more people at a large dinner table than in the courtroom.
Can I stay after I testify? Yes. In most cases you will be done by 9:30 am. P-PTN welcomes you to stay…but the decision to observe all or part of the further proceedings should be based on your supervisor's permission and the needs of your property.
What do I wear? Business dress is appropriate.
I'm still nervous! Don't be. Before the trial we will review with you the documents that we will be submitting, discuss the process in greater detail, give you detailed information on time, address, etc.
ps: Don't forget to add: " Testified on behalf of my property at a trial" to your resume.
1. How large are refunds?
Good Question! During our careers our team members have worked on successful appeals that resulted in cash refunds/savings to the taxpayer ranging from under $1,000 to much, more than $1,000,000. Not all cases result in a refund.
2. What about personal property taxes? Do you appeal those too?
YES. We pursue personal property tax appeals with the same vigor we use on real property tax appeals. We recently had a victory on a personal property appeal where we lowered the taxable basis of some personal assets by over $1.6 Million.
3. What are your qualifications?
LEGAL: Our lead negotiator, Scott Phinney was an attorney and Chief Hearings Officer for the State of Oregon when the voters passed Measure 5. He was one of a handfull of experts tasked with creating a new appeal system for Oregon. Know the law? He helped write it. He has used the last 20 years to expand his sphere of excellence to include Washington and California appeals in addition to Oregon.
VALUATION: Our lead valuator (Rick Bean) writes a real estate investment blog based on his experience in researching diverse real estate markets in multiple states. He has worked on acquisitions and dispositions for a REIT on multiple sub categotries of real estate ranging from $100,000 to $106,000,000.
4. Do you handle Oregon property tax appeal cases for every County?
YES. We work appeals for all of Oregon…and we also prosecute appeals for Washington and California.
5. What if I have a portfolio with commercial properties in many states?
That's not a problem for us. We actively pursue personal and real property tax appeals in Oregon, Washington and California. We also have relationships with other successful firms throughout the nation. We coordinate appeals and provide a single source solution. We have multiple clients that have 50 or more commercial properties.
6. Does it really make a difference to use a local property tax appeal solution?
YES. Your interests are best served by having a property tax reduction advocate that has relationships with the county apprasers and an understanding how each county operates differently. You don't want a vendor that shies away from Santa Barbara, CA appeals because he thinks their filing fee is $1,000. It is…but only for assets larger than $30,000,000. For most appeals their fee is an affordable $65. Local knowledge let's us know which 9 California counties close their appeals 45 days before the rest of the state.
Washington State's filing deadline is June 30th…but if you read the fine print it's actually the later of that date or 30 or 60 days after the mailing date of valuation change notices. Local knowledge allows us to know that in Washington, King and Clark counties usually mail their statements as late as the end of September and that they are "60 day" counties…meaning that some appeals may be valid if filed as late as November 22nd.
Local knowedge of the laws and appeal procedures is more important in Oregon than any other state in the union. Understanding compression refunds and trigger points is vital to receiving the optimum refund. It's complex, which is why so few national property tax appeal firms have a presence in Oregon. They are more attracted to lower hanging fruit elsewhere.
1. What is the Oregon Property Tax appeal deadline?
10PM on 01/03/12 is the deadline this year. Best practice is to have your property tax appeal advocate selected, be signed up and have your tax statement forwarded to them by 12/15/11.
2. Do I have to have someone do this for me?
A. BOPTA. (Board of Property Tax Appeals) After we've filed your initial appeal we will research your property and others like it that have been sold, for sale, and for lease. We will look at several valuation approaches including capitalization of revenue. We will testify on your behalf at BOPTA in the county where the property is located. The BOPTA panelists are independent from the county. The calibre varies widely from exceptionally dedicated and knowledgeable to those for whom that would not be applicable.
B. Magistrate Tax Court. If we appeal to the second level we will do additional research and testify on your behalf and testify at Magistrate Tax Court in Salem, OR. We will supply expert witnesses and cross-examine the county staff. A robed judge will render a verdict.
C. Regular Tax Court. Still not satisfied? We can re-appeal to Regular Tax Court. This is the highest level for appeals based on the value evidence. Like Magistrate Tax Court this is held in Salem and a highly professional robed judge will preside. Note: There is also the Oregon State Supreme Court…but that is for contesting the interpretation of the law, rules of evidence, etc.
Over the next few weeks Oregon's Property Tax Appeal Campaign will kick off in earnest. Prime PTN hopes to demystify the property tax appeal process by listing the most frequently asked questions and their answers. We'll have several installments. We take a client centric approach…feel free to contact us directly with questions at: info@primeptn.com.
1. Is it really possible to get a property tax refund in Oregon?
YES! This is perhaps the most pervasive myth that Prime PTN hears nearly everyday. We've had many successes for the most recent appeal season…and past seasons as well. Refunds have ranged from thousands to tens of thousand of dollars.
2. Does it cost a lot of money upfront?
NO. We evaluate your case for free. Professional fees are on a contingency basis only…If we don't win we don't get paid. We do ask clients to pay filing fees, but relative to the potential tax savings they're comparatively small.
3. Do I always have to get and pay for an appraisal to win?
NO. To be successful at property tax appeals requires valuation skill and exceptional legal acumen. Most firms have one or the other. We pride ourselves on having both. Most of the cases we have won have been without appraisals. If they are available we would want to have them. If they're not…then we would rather work a bit harder and give our clients a higher return. We would tell you if an appraisal was required and get your approval before spending money.
4. The County Appraiser told me in order to get a property tax refund, I had to prove that the Market Value was lower than the Appraised Value. True?
NO. Compression refunds often start well above the Assessed Value. Prime PTN has a proprietary program that calculates where refunds start and how much might be possible. This is only an estimate…the actual refund (if any) will be determined by the court's judgement based on the evidence both sides offer and applicable statutes and case law.
Prime PTN sends a thank you to Thomas D. of San Francisco, CA for a great question! Thomas e-mailed me saying that our website shows us to be experts in property tax appeals…but can we assist with personal property assessment appeals as well?
The answer is: Yes…we seek engagements of this type and we'll have to make it clearer on our site that personal property appeals represent a key component of our overall service offerings. We pursue Oregon personal property tax appeals as well as Washington and California personal property tax appeals. As always, for multi-state portfolio owners we prosecute appeals directly in Oregon, California, and Washington, and coordinate additional state appeals. We offer a seamless single source solution to regional or national asset appeals.
By the way, Thomas…banks do not consistently manage their property tax liabilities well. There may be some lower hanging fruit in both the REO area and personal property categories.
The state of Washington's property tax appeal deadline is June 30th, or 60 days after the mailing date of the value notices. This means that almost a month after the official deadline that many (most) Washington residents can still file valid appeals. Each county does it a little differently. Most of our clients tell us that King and Clark County haven't sent out notices yet. Remember: The appeal deadline clock starts ticking the day they are sent, not the day they arrive.
Get ahead of the game. You can contact Prime Property Tax Negotiation to file your appeal even before your receive your statement. Contact us today at 503.577.1034, or info@primeptn.com.
HEADS UP CALIFORNIA: Property Tax Appeal campaign starts in 48 days!


LANDLORDS are being asked to give their opinions on a new initiative which will provide them with a series of benefits.
North Herts District Council is launching a deposit guarantee scheme later this year to help people who can't afford a deposit on a rented house as well as the landlords themselves.
Under the scheme, the council will give landlords a guarantee of payment up to an agreed level in the event of damage, theft or rent arrears.
There are no agent's fees involved and there are also a series of add-on services for landlords such as rent in advance, tenancy support and fast-tracking housing benefit.
NHDC is now consulting landlords who have properties in the district to make sure the new service will meet their needs.


text:
Q: Display Instagram User "Follower Count" - Wordpress Plugin I already have a plugin that let's users authenticate into their wordpress account, and that plugin displays the users recent photos.
I also want to pull in their follower count.
I've tried going through the API and my plugin code to find the right snipper to insert, but haven't found a solution yet.
Here is the plugin JS file, can someone help me?

(function( $ ) {
 'use strict';

 jQuery(document).ready(function(){

  // Init
  um_instagram_get_photos();

  /**
   * Init Gallery
   */
  function um_setup_instagram_gallery(){
   // Show first 5 instagram photos on load
   jQuery('#um-ig-photo-wrap ul li:gt(5)').addClass('hidden');
   var $ul_gallery  = jQuery('ul#um-ig-show_photos');
   var $nav_previous  = jQuery('#um-ig-content .um-ig-photo-navigation a.nav-left');
   var $nav_next   = jQuery('#um-ig-content .um-ig-photo-navigation a.nav-right');
   var $um_paginate  = jQuery('.um-ig-paginate span');
   var gallery_page  = $ul_gallery.find('li:not(.hidden) img').length;
   var total_photos  = $ul_gallery.attr('data-photos-count');
   var is_viewing      = $ul_gallery.attr('data-viewing');
   var paginate   = 1;
   var max_photos   = 18;
   var items_per_page  = 6;

   // Hide previous button on load
   $nav_previous.addClass('nav-hide');

   // Show paginate on load
   $um_paginate.text( gallery_page +'/'+total_photos );

   // Hide Next button last page reached
   if( total_photos < items_per_page ){
    $nav_next.addClass('nav-hide');
   }

   // Previous
   $nav_previous.on('click',function() {

     paginate--;

        var current_visible_photos = $ul_gallery.find('li:not(.hidden) img').length;

        var first = $ul_gallery.find('li:not(.hidden)').first();
        first.prevAll(':lt('+items_per_page+')').removeClass('hidden');
        first.prev().nextAll().addClass('hidden');

         gallery_page -= current_visible_photos;

        if( total_photos > items_per_page && total_photos > gallery_page  ){
         $nav_next.removeClass('nav-hide');
     }

     if( gallery_page == items_per_page ){
      $nav_previous.addClass('nav-hide');
     }

        $um_paginate.text( gallery_page +'/'+total_photos );

   });

   // Next
   $nav_next.on('click',function() {

    paginate++;

    var last = $ul_gallery.find('li:not(.hidden)').last();
       last.nextAll(':lt('+items_per_page+')').removeClass('hidden');
    last.next().prevAll().addClass('hidden');

    var current_visible_photos = $ul_gallery.find('li:not(.hidden) img').length;
    gallery_page += current_visible_photos;

       if( total_photos > gallery_page  ){
         $nav_next.removeClass('nav-hide');
    }

    if( total_photos == gallery_page  ){
         $nav_next.addClass('nav-hide');
    }

    $nav_previous.removeClass('nav-hide');

       $um_paginate.text(gallery_page+'/'+total_photos );

   });

   // Disconnecet instagram account
   jQuery('.um-ig-photos_disconnect').on('click',function(){
    jQuery('.um-ig-photos_metakey').val('');
    jQuery('.um-form form').submit();
   });

   // Add photo opacity effects on hover
   jQuery("#um-ig-photo-wrap a img").hover(function(){
       jQuery(this).stop().animate({"opacity": 0.7});
   },function(){
       jQuery(this).stop().animate({"opacity": 1});
   });
  }

  /**
   * Ajax get instagram photos
   */
  function um_instagram_get_photos(){

   var $um_photo_wrap = jQuery('#um-ig-photo-wrap');
   var metakey = $um_photo_wrap.attr('data-metakey');
   var viewing = $um_photo_wrap.attr('data-viewing');
   var $body_classes = jQuery('body').attr('class');
   var user_id = 0;
   var cl =  $body_classes.split(' ');

   if( cl.length > 0 ){
    jQuery.each(cl,function(i,cs){
     if( cs.substr(0,14) == "um-profile-id-" ){
      user_id = cs.substr(14);
     }
    })
   }

   jQuery('#um-ig-preload').css('background','url('+um_instagram.image_loader+') no-repeat  50% 50%');

   if( viewing == 'true' ){
    jQuery.ajax({
     method: 'POST',
     url: um_scripts.instagram_get_photos,
     data:{
      metakey: metakey,
      viewing: viewing,
      um_user_id: user_id
     },
     success: function( response ){
      $um_photo_wrap.html( response.photos );
      um_setup_instagram_gallery();
      um_instagram_preload();
     },
     error: function( e ){
      console.log(e);
     }

    });
   }else if( viewing == 'false' ){ // Edit profile view
    um_setup_instagram_gallery();
    um_instagram_preload();
   }
  }

  /**
   * Lazy load
   */
  function um_instagram_preload(){
   // Remove preload
   setTimeout( function(){
    jQuery("#um-ig-preload").fadeOut();
    jQuery("#um-ig-content").fadeIn();
   }, 5000);
  }
 });

})( jQuery );

redpajama_set_name: RedPajamaStackExchange


Expandable system lets you customize your wall filing system. Simply add pockets as your organization needs grow. Mounting hardware included. Plastic. Hanging File Systems Type: Expandable Single Pocket; For File Size: Letter; Overall Height: 7"; Width: 13".


text:
Research: BYOD booming with 74% using or planning to use
Drunken Monkey Hypothesis: Was Booze an Advantage For Our Ancestors?
Lunar Tales: The First (Imaginative) Moon Landings
Ancient DNA Study Reveals Deep Roots of Modern Grapevines
Record Rain Is Drowning Fields in the Midwest — Is It Climate Change?
Theres An Enormous, Mysterious Mass Under the Moons Largest Crater
Global Astronomy Groups Say Theyre Concerned About SpaceXs Starlink Satellites
Humans Ability to Hear Harmonic Sounds Might Set Us Apart
Catching A Whiff Of T. Rexs Sense Of Smell
Our Sun Is Capable of Producing Dangerous Superflares, New Study Says
Your GmTserver
Where Stories Are Wild And Trendy
Science-and-Nature
Home /Faint Starlight in New Hubble Images Lets Astronomers See Dark Matter
TechnologyDecember 28, 2018
Faint Starlight in New Hubble Images Lets Astronomers See Dark Matter
Intracluster light (blue) in the galaxy cluster Abell S1063. One new technique uses intracluster light, imaged by Hubble, to map and study dark matter. (Credit: NASA, ESA, and M. Montes (University of New South Wales, Sydney, Australia)
Two astronomers have devised a method that lets them "see" dark matter with the light from rogue stars. The pair has shown how images of faint starlight taken with the Hubble Space Telescope can be used to map dark matter's distribution in galaxy clusters. The novel technique could ultimately help explore the nature of dark matter.
Dark matter remains one of the great mysteries of modern science. A theoretical form of matter, dark matter is thought to make up about 85 percent of all matter in the universe. Because dark matter doesn't absorb, reflect or emit light, it is very hard to spot. In fact, it has never been directly observed and some even question whether or not it actually exists.
This new method, however, lets astronomers detect dark matter in galaxy clusters using what's called intracluster light. Intracluster light is faint starlight that's created by interactions between galaxies. When galaxies interact, their respective stars can be ripped apart from them, left to float freely throughout the galaxy cluster.
"These stars have an identical distribution to the dark matter, as far as our current technology allows us to study," lead study author Mireia Montes of the University of New South Wales, said in a statement.
Because the intracluster light aligns with the dark matter in these clusters, it allows astronomers to see how the dark matter is distributed. In this study, the pair of astronomers used data from the Frontier Fields Hubble Space Telescope program. The research is published in Monthly Notices of the Royal Astronomical Society.
"Seeing" Dark Matter
"We have found a way to 'see' dark matter. We have found that very faint light in galaxy clusters, the intracluster light, maps how dark matter is distributed," Montes said about this new method.
Other efforts to map the distribution of dark matter use gravitational lensing — a technique that uses the light bent by matter in between a light source and the observer. But, while gravitational lensing requires accurate lensing and time-intensive spectroscopy, this new technique only requires deep-space imaging. Because of this, the astronomers who devised the new technique say it will be a more effective tool for mapping and studying galaxy clusters.
Aside from providing an effective method with which astronomers can map dark matter, this new research also offers opportunities to better explore the nature of dark matter itself. For example, dark matter appears to interact with regular matter only gravitationally. But, if researchers using this method find that dark matter actually distributes differently than the floating starlight, it could mean that dark matter is self-interacting. This would significantly change our current understanding of dark matter, what it might be, and how it behaves.
Oldest Evidence for Weed Smoking…
NASA is Retiring Its Legendary…
10 ways alternative energy is…
Research shows BYOD use growing…
New Horizons Survived its Flyby…
Do Our Odds of Dying…
Instead of Throwing Christmas Trees…
New Horizons First Close-up Pictures…
Climate Change Could Ramp Up…
Chinas Change-4 Spacecraft Ready to…
Main 1
Science-and-Nature 63
Research: BYOD booming with 74% using or planning to use June 26, 2019
Drunken Monkey Hypothesis: Was Booze an Advantage For Our Ancestors? June 14, 2019
Lunar Tales: The First (Imaginative) Moon Landings June 14, 2019
Email: support@gmtserver.com
Address: Europe/Amsterdam
All rights reserved GMTserver.com


text:
Vol. 13, Issue 185 - Thursday, July 3, 2008
About | Mobile edition | Corrections | Calendars | Movies
T | F | S | S | M | T | W
RSS/XML Feeds Freelancers
Damien miracle passes papal muster
Canonization awaits now that Benedict has affirmed the vote of a Vatican council
» Kalaupapa exults 'Saint' Damien
By Victor L. Simpson
VATICAN CITY » Pope Benedict XVI today approved a miracle attributed to the intercession of a 19th century Belgian priest who ministered to leprosy patients in Hawaii — opening the way for him to be declared a saint.
Benedict declared that a Honolulu woman's recovery in 1999 from terminal lung cancer was the miracle needed for canonization of the Rev. Damien de Veuster. The miracle was attributed to the intercession of the late priest, to whom the woman, Audrey Toguchi, had prayed.
The approval means that Father Damien, beatified by Pope John Paul II in 1995, will be canonized at a date still to be set.
The Vatican's Congregation for the Causes of Saints had said Toguchi's recovery defied medical explanation, and today the pope told the sainthood office's leader, Cardinal Jose Saraiva Martins, that he agreed, the Vatican said.
"It's such an exciting time in our lives that one of our men, one of us here in Hawaii, has attained the highest rank of sanctity and will soon be declared a saint in the church," said the Rev. Christopher Keahi, head of the Sacred Hearts order of Hawaii.
Born Joseph de Veuster in 1840, Damien went to Hawaii in 1864 and joined other missionaries of the Congregation of the Sacred Hearts of Jesus and Mary. Nine years later, he began ministering to leprosy patients on the remote Kalaupapa peninsula of Molokai, where about 8,000 people had been banished amid an epidemic in Hawaii in the 1850s.
The priest eventually contracted the disease, now known as Hansen's disease, and died in 1889 at 49.
Honolulu Bishop Larry Silva said canonization is important, "not simply as a recognition of the saintly heroism of Father Damien, but so that, following his example, we may all be renewed in holiness and in our dedication to those brothers and sisters who are most in need."
The Vatican's saint-making procedures require that a miracle attributed to the candidate's intercession be confirmed in order to be beatified. Damien was beatified after the Vatican declared that the 1987 recovery of a Sacred Hearts of Jesus and Mary nun was a miracle. The nun recovered from an illness after praying to Damien.
After beatification, a second miracle is needed for sainthood.
A date for canonization was not expected to be set until February. Damien's body was exhumed from his Molokai grave in 1936 and his remains sent back to Belgium for reburial. In 1995, a relic of his right hand was given back to the Hawaii diocese and returned to the Molokai grave.
Associated Press Writer Jaymes Song in Honolulu contributed to this report.
MAN OF MIRACLES
Gone are the days when miracles involved loaves, fishes and the parting of seas. Modern miracles typically are so-called acts of intercession, when the faithful pray to a deceased holy figure to intercede with God on their or another's behalf, often to cure an illness. If the illness then is cured — and a medical review panel finds the cure dramatic and unexplainable — that holy figure is viewed as having special influence with God. Two miracles have been credited to Father Damien:
» In September 1895, Sister Simplicie Hue, 37, a nun in France, prayed to Damien to intercede as she lay near death with an intestinal illness that modern doctors suspect might have been ulcerative colitis. The pain and symptoms disappeared overnight. Pope John Paul II recognized that as a miraculous cure in 1992 and Damien was beatified three years later. Sister Simplicie prayed to Damien, who died in 1889, because he was a member of the same order, the Congregation of the Sacred Hearts of Jesus and Mary.
» In a case documented in October 2000 issue of the Hawaii Medical Journal, Audrey Toguchi, a former Aiea High School teacher, experienced a "complete spontaneous regression" of lung cancer in 1998 after praying to Damien and making pilgrimages to Kalaupapa. Toguchi, 79, granddaughter of a former Hansen's disease patient, told the Star-Bulletin earlier this year that the cancer disappeared over the course of four months. Father Bruno Benati, general postulator for Damien's cause, announced last month that the Congregation of Saints' Causes had ruled the cure a miracle linked to her prayers.
Inside | July 3
» Family killed in Mililani
» Damien miracle passes papal muster
» Kalaupapa exults 'Saint' Damien
» Lingle 'likely' will sign anti-rail petition
» Wyland targets Kauai for hotel redevelopment
» Robotics students flex their chips
» Kauai drive-by shooting described
» Witnesses describe events before killing
» 50,000 expected for park fireworks
» Be mindful of smoke-sensitive people
» Isle journalists get 'shield' law
» Kokua Line: Foul-smelling bus seats
» Pet Ohana: Dog development
» On the Scene
» Shining Stars
» Summer savvy looks for guys and gals
» Honolulu Lite: Crime news rocks
» Fans rally behind Stone
» Coco Palms could be next for Wyland
» Banmiller may return to Air Jamaica
» Industrial market vacancy rate rises
» May hotel occupancy drops slightly
» Hotels struggle to sustain workforce
» TheBuzz: American ATMs speak Chinese
» Cheer for Bryan Clay in 2008 Olympics
» From the Capitol: Fire-damping legislation
Columns | July 3
Kokua Line
June Watanabe
Honolulu Lite
Charles Memminger
E-mail City Desk
Terms of Use | Subscribe | Advertise | Classifieds | Advanced Search


Free cigarettes State Express merchandise catalog. Cigarettes buy online London, Benson Hedges cigarettes coupons by mail, Free cigarettes State Express merchandise catalog, Cigarette Sobranie light, Cigarettes outlet matamoras, Cheap Gauloises cigarettes online free shipping, How much does a Superkings cigarette, Cheap tobacco foley al, American made cigarettes Kool online, Price of State Express in the UK. A specific wave shape (flute) in the inner portion of combined corrugated board. Wholesale C-Store Items: Your Source for Wholesalers, Distributors, Importers and Manufacturers.Comprehensive online search results for for comic books and graphic novels Click free cigarettes State Express merchandise catalog all of your favorites below! 1. A specific wave shape (flute) in the inner portion of combined corrugated board. STATE ARCHIVES PHYSICAL ADDRESS. Comprehensive online search results for for comic books and graphic novels Click all of your favorites below! 1. 99 cent Medium Pizza or Free Cheesesticks from Papa John's.Express Helpline- Get answer of your free cigarettes State Express merchandise catalog question fast from real experts B flute corrugated paperboard. General Information Introduction to Catalog and Handbook Resources. Large database of live auctions. Eastbay began its operations as a direct-mail catalog. Considered the most. WalkAbout ® Lite 3 luggage is the ultimate in lightweight. Check out all the latest CafePress coupon codes, promo codes & discounts for 2017. View Give Me Liberty!_ An American H – Eric Foner from HIS 1005 at CUNY Baruch. Get access to the latest and greatest computer games & downloads. We help lower your price.Students are responsible for keeping themselves informed free cigarettes State Express merchandise catalog on the policies that govern educational. It measures 3/32 of an inch. STATE ARCHIVES MAILING ADDRESS State Archives of North Carolina 4614 Mail Service Center Raleigh, N.Travelpro walkabout® lite 3 cigarettes coupons for parliament printable black horizontal rolling garment bag. Here are the top eight reasons why last year more than one million Oklahomans filed their tax returns electronically: It's easy. Students are responsible for keeping themselves informed on the policies that govern educational.C. General Information Introduction to Catalog and Handbook Resources.2 price of sobranie silver . 2. Join the NASDAQ Community today and get free, instant access to portfolios, stock ratings, real-time alerts, and more! Join Today.Students are responsible for cigarette store corp keeping themselves informed on the policies that govern educational.2 free cigarettes State Express merchandise catalog.Check free cigarettes State Express merchandise catalog out all the latest CafePress coupon codes, promo codes & discounts for 2017.Travelpro paypal lambert butler cigs Crew 7 Horizontal Rolling. Comprehensive online search results for for comic books and graphic novels Marlboro Cigarettes for $18. STATE ARCHIVES PHYSICAL ADDRESS. STATE ARCHIVES PHYSICAL ADDRESS.. Credit and loans are a massive, multi-trillion dollar/year international field/industry which the below superb, very memorable generic credit/loan domains quickly. Travelpro Crew 7 Horizontal Rolling.C.27699-4614 superkings light sklep . Remember: Check Groupon First Best Cigar Deals Want cheap cigars and freebies? Stock up on your favorite premium brands at discount prices or enjoy bonus offers with free stogies and accessories!


text:
import Shipit from './Shipit'

module.exports = Shipit

redpajama_set_name: RedPajamaGithub


text:
Q: Set Size of Rectangle to image size i'm using this, to show icons that can change their color
<Rectangle Width="100"
           Height="100"
           Fill="{DynamicResource WhiteBrush">
   <Rectangle.OpacityMask>
      <ImageBrush Stretch="Uniform" ImageSource={x:Static ImageResources.MyImage}"/>
   </Rectangle.OpacityMask>
</Rectangle>

The thing is, that not every Image looks good in 100x100 and if I do not fill these values, nothing is shown. What I wanted to achieve is, that the rectangle automatically takes the needed size of the Image, same as if I would use
<Image Source="{x:Static ImageResources.MyImage}"/>

Any Idea how to achieve this? I already tried to give the ImageBrush a name and reference the size from the rectangle, this doesn't work.
As a workaround I placed an Image at the same position with Visibility=Hidden and get the actualHeight and actualWidth for the Rectangle from there, but that's not an acceptable solution. Any hints welcome.

A: You could bind the Rectangle's Width and Height:
<Rectangle Fill="{DynamicResource WhiteBrush"
           Width="{Binding Width, Source={x:Static ImageResources.MyImage}}"
           Height="{Binding Height, Source={x:Static ImageResources.MyImage}}">
    <Rectangle.OpacityMask>
        <ImageBrush ImageSource="{x:Static ImageResources.MyImage}"/>
    </Rectangle.OpacityMask>
</Rectangle>


text:
Bryan Viewpoints speaker Gillian Munson discusses her 'fascinating ride' in venture capital
February 10, 2020 thesewaneepurple News Leave a comment
Pictured: Gillian Munson. Photo courtesy of usv.com.
By Colton Williams
The Babson Center's Bryan Viewpoints Speaker for 2020 was Gillian Munson, a venture capitalist at Union Square Ventures, one of the world's largest private equity firms. Munson visited Sewanee on January 29, where she stopped by classes and gave a lecture, titled "Venture Capital Today: The Fascinating Ride of an Internet Entrepreneur and Investor."
Munson is the operating partner at Union Square Ventures, headquartered in New York City. She runs the firm from an operations perspective, while also investing as a venture capitalist. Venture capitalists infuse capital into a company, typically at its early stages, to help fund the company's growth. The investments are made as equity, so that if the company succeeds, the venture capital firm owns a component of the company, and if it fails, they lose their money. The firm focuses on technology, and has made investments in notable companies such as Twitter, Etsy, MongoDB, Cloudflare, Coinbase, Carta, and Duolingo.
Over the course of Munson's career, she has worked both operated and invested in companies. "My career has gone back and forth between operating companies and investing in companies," Munson said. "I've actually spent more time in the investing side, so early in my career, I was what they call a sell-side research analyst, so the best way to think about that is the folks that get on CNBC and say 'buy this stock, sell this stock,' that was what I did."
Before joining Union Square Ventures, Munson worked as Chief Financial Officer at the public company XO Group, and at the investment bank Allen & Company.
Though Munson has worked in many different capacities, she sees the essential thread in her career as being "a student of business, and trying to operate businesses and invest in businesses using those skills together."
Munson didn't always know that she wanted to work in venture capital, but she did always have her eye on the financial world. "I knew in college that I might want to be in business," Munson said. "I liked working with numbers, and I felt like some job that got me somewhere in the financial world would make sense."
After graduating from Colorado College with a degree in economics, Munson, who is originally from the East Coast, kept moving west before eventually landing in San Francisco.
"I started to interview with people in that business," Munson said, "and ultimately found someone who was a research analyst, and I was so fascinated by what his job was that I said 'oh, I want to do that.'"
Critical for Munson is the point at which her career began. Most of her career has been spent working in the technology sector. "I've always tried to keep moving forward to things that are interesting along the way," Munson said, "and I've been really lucky because my first job was in the technology investing business, and that was in 1992."
Since then, the technology market has grown exponentially. Munson even joked that when she went to college, there was no internet and no computers: she was armed only with a Smith Corona word processor.
"So I hit it at the right time," Munson said. "It's a fascinating industry and a fascinating business that's changed people's lives immeasurably. It's been such a fun industry to be in, I can't imagine being in another."
Though 'Big Tech,' as it is often called, is constantly under scrutiny, Munson sees both advantages and disadvantages to the ubiquity of technology in everyday life.
"I think that the remarkable increase in progress as a result of a connected world is tremendous," Munson said. "There's a lot of human progress as a result of tech."
In addition, Munson also addressed some of her concerns about technology, including the oversized share of the market held by Facebook, Amazon, Netflix, and Google, as well as disruptions in political processes aided by technology.
What most concerns Munson, however, is the social side effects of technology usage. "Right now, we are seeing rates of depression in young folks that are sort of unprecedented," she said. "… technology sometimes makes that worse."
In her advice to students entering business or any other field, Munson said "I really believe in staying positive and working hard. It doesn't always happen, not everyday is great… but in general I just think that there's a lot of opportunity out there and with a great education like you guys have here, and a little creativity, people can craft together really interesting, fun careers."
Munson, who clearly enjoys her work and career, advised students that though work is work, they should enjoy what they do. "It is the majority of your life," she said. "So you might as well have fun doing it."
Previous Post: Not even a New York Times article could get the University to start listening
Next Post: International students face unique challenges over winter break


I always knew I would be a scientist, though exactly what kind of scientist evolved slowly…and keeps evolving, for that matter.
As a child, in those years where only PBS stations provided educational programming, I was fascinated by nature and science shows. I distinctly remember the very first episodes of the long-running show, Nature, episodes entitled "Flight of the Condor." Things like that just riveted me to the screen just as much as old Godzilla movies or the original Dr. Who show. I sucked in from PBS hours of science shows and always wanted to know more. It was inevitable, from that first moment of realizing how fun it was to learn how the world worked, that I would reach a point where the questions I asked had not been answered yet. That was when I knew I wanted to be one of the people who answered unanswered questions…a scientist.
I can attribute my ultimate focus on molecular biology to a particular college professor. As an undergraduate, I took an upper division Molecular Biology class at the University of California, San Diego. The professor was very tough. She covered an enormous amount of material each lecture. Her pattern was to go rapidly through the material until the last 10-15 minutes of class. Then she would realize she was behind her planned schedule and say, "Oh, I better speed up!" The class would always groan with fear of the massive flow of information that they knew was about to be unleashed upon us. It was difficult but I ate it up. I remember thinking to myself frequently during the course, "Wow, people can really DO THAT?" It was an introduction to some of the deepest secrets of biology that I had never heard about before that class. I was hooked.
It was my first time in lab and I loved it. Learning, interacting with other scientists, doing REAL experiments with carefully designed controls. I worked with a post-doc who was the last person in her lab to focus on prokaryotic gene regulation. My project now sounds so old…but it was still an open question then. We wanted to know if the geometry of the DNA molecule influenced the ability of transcription factors to initiate transcription. We studied the good old Lac operon in E. coli, varying the distance between the -10 and -35 promoter regions and seeing how this influenced the expression of the β-galactosidase gene. Our hypothesis was that as we increased the distance between the two promoter regions, we would slowly lose expression…until we reached approximately 10 base pairs added (one turn of the DNA helix). We expected to get at least some restoration of activity because the promoter binding proteins, though the distance between them was increased, would at least still be on the proper side of the DNA molecule relative to each other.
A summer of β-Gal assays, with solutions staying clear or turning yellow in test tubes and measured in a spectrophotometer, showed us our hypothesis was correct. The data was about as clear as could be. As I left my summer project, there were just a few other experiments to be finished before the lab planned on publishing.
I went back to school and soon after the post-doc I had been working with moved on. The rest of the lab was working on eukaryotic projects and no one was left to finish the work I had been a part of. In my naiveté, I assumed SOMEONE would finish it up because we had pretty much PROVEN our hypothesis. I mean, how cool is that? Science works! Hypothesis, experimental design, controls and all and we proved our hypothesis.
I moved on as did everyone else. The work never got published as far as I am aware.
Fast forward to my first year of Grad school. I had graduated from UCSD, spent some time in the South Pacific, and then worked as a lab tech at UCLA before entering a graduate program at UCLA. I had even published my first paper as a first author. I had largely forgotten my undergraduate time in a lab.
Our first year was intense. Each quarter we had a tough class as well as rotation projects. My rotation projects were fascinating. Discovering some really cool things about homeobox genes and about a mysterious ribonuclear protein particle in cells called a vault. Both rotation projects went the same road as my undergrad project, never seeing publication despite great results…though one of them led to someone else's cool and successful graduate project. I chose not to pursue either of those projects but returned to get my Ph.D. in the lab where I had worked as a technician and where I had already published one paper.
But my first year of grad school, while taking our required, difficult but fascinating Macromolecular Structure class, we were being introduced to gene regulation. The professor was talking about prokaryotic gene regulation…and started talking about the geometry of protein binding to the DNA helix. He said he had talked to some of his connections in the field and the latest unpublished work in the field was that as you vary the distance between the -10 and -35 promoter regions of a prokaryotic promoter you lose expression until you get one turn of the helix away, at which point you see some restoration of expression.
The professor teaching me was quoting the very work I had done some years back! It may never have been published, but it had become part of the wisdom passed on to graduate students…including to me. It renewed the thrill that had started in that Undergrad Molecular Biology class and continued through that summer of research when I first started putting in 12 hour days out of sheer enthusiasm.
We all have work we have done that may have been great, but still never quite made it to publication. The real lesson is don't leave the lab and expect things to be continued, though another project of mine many years later did get published, with me still as co-first author, some 2 years after I had left the lab. So you never know.
The saddest part of science to me is all the information that never gets published. Sometimes people leave and no one ever picks it up again even though only a few more experiments could finish it off. Other times the data is good but doesn't come together as a "good story." Or the story is good and helpful, but largely negative data. I heard about a time when people from another lab were shown one of my lab notebooks of carefully done, but unpublished data. They looked through it and said, "If we had known this it would have saved us so much time!" It had never gelled into a "good story," so everyone had moved on from it…yet that meant other labs had to repeat what we did because no one knew we had done it.
It is a flaw in our system that possibly some of the newer, online-based journals can remedy…a way to publish negative data or data that doesn't gel into a "good story" but still is important to the field.
Science is amazing and it is fun. But there is a sea of unpublished data out there, mostly just as carefully done and as informative as the published data. However, the way papers get published means more and more good data falls by the wayside. The tumorous growth of "Supplemental Data" kind of helps, but it has gotten out of hand, to the point where every good paper is expected to have at least a whole other paper hidden away in its "Supplemental Data" section. It is better than losing that data to the vast sea of unpublished data, but it isn't as good as having a respected way of publishing, with peer review, some of the data that currently gets left behind. A simple cost-benefit analysis would show, as those people from another lab expressed looking at some of my unpublished, orphan data, that labs could save a great deal of time if we all could find a place to publish our negative and orphan data that doesn't fit into the kind of story that one has to construct to get a paper accepted these days.
Still, I learned in grad school that even unpublished data can still seep, almost as if by osmosis, into the scientific community and make it to a graduate level course.


Alan Stubbs reckons Barkley's immediate future lies away from Everton.
Stubbs told talkSPORT. "I think Ronald put his cards on the table with Ross before the end of the season and he gave him an ultimatum.
"The fact that we are three weeks gone and Ross hasn't signed, then I think that's the biggest indicator that Ross' future is going to lie elsewhere.
"Potentially it's the most exciting pre-season that I've probably seen at Everton for a good five or 10 years," Stubbs added.
"We have an owner (Iranian billionaire Farhad Moshiri) who is ready to back the club and I think he is trying to get his business done early and the first two signings look really good and I think there will be plenty more.
"I think Everton will potentially be spending over £100m and I didn't think I'd ever be saying that.
"We are now waiting to see if Romelu stays or goes. The sooner that cloud is removed, whether he is staying or going, it is better for the club so they can move forward.


text:
Red hair-related gene variant may contribute to link between melanoma and Parkinson's disease
A gene variant that produces red hair and fair skin in humans and in mice, which increases the risk of the dangerous skin cancer melanoma, may also contribute to the known association between melanoma and Parkinson's disease. In their paper appearing in the March issue of Annals of Neurology and previously published online, Massachusetts General Hospital (MGH) investigators report that mice carrying the red hair variant of the melanocortin 1 receptor (MC1R) gene have reduced production of the neurotransmitter dopamine in the substantia nigra -- the brain structure in which dopamine-producing neurons are destroyed in Parkinson's disease (PD) -- and are more susceptible to toxins known to damage those neurons.
"This study is the first to show direct influences of the melanoma-linked MC1R gene on dopaminergic neurons in the brain and may provide evidence for targeting MC1R as a novel therapeutic strategy for PD," says Xiqun Chen, MD, PhD, of the MassGeneral Institute for Neurodegenerative Disease (MGH-MIND), lead and corresponding author of the report. "It also forms a foundation for further interdisciplinary investigations into the dual role of this gene in tumorigenesis within melanocytes - the pigment cells in which melanoma develops - and the degeneration of dopaminergic neurons, improving our understanding of why and how melanoma and Parkinson's disease are linked."
Inherited variants of the MC1R gene determine skin pigmentation, with the most common form leading to greater production of the darker pigment called eumelanin and the red-hair-associated variant, which inactivates the gene's function, increasing production of the lighter pigment called pheomelanin. Not only does pheomelanin provide less protection from ultraviolet damage to the skin than does eumelanin, but a 2012 study led by David Fisher, MD, PhD - chief of the MGH Department of Dermatology, director of the Cutaneous Biology Research Center and a co-author of the current study -- found it also may directly contribute to melanoma development.
While patients with Parkinson's disease have a reduced risk of developing most types of cancer, their higher-than-expected risk of melanoma is well recognized, as is the increased risk of PD in patients with melanoma. Several recent studies also have found evidence suggesting increased PD risk in individuals with red-hair-associated variants of MC1R, so the current study was designed to explore that potential role of the gene in PD and specifically in dopamine-producing neurons of the substantia nigra.
Development and validation of 2-gene host-based COVID-19 diagnostic classifiers
Study finds evidence to strongly implicate OAS1 as an effector gene influencing COVID-19 severity
The team's experiments showed that, in mice with the common form of MC1R, the gene is expressed in dopamine-producing neurons in the substantia nigra. The red-haired mice in which the gene is inactivated because of a mutation were found to have fewer dopamine-producing neurons and as they aged developed a progressive decline in movement and a drop in dopamine levels. They also were more sensitive to toxic substances known to damage dopamine-producing neurons and had indications of increased oxidative stress - which the 2012 study implied was involved in pheomelanin-associated melanoma risk - in brain structures adjacent to the substantia nigra. Treatment with a substance that increases MC1R signaling reduced the susceptibility of mice with the common variant to a neurotoxin, further supporting a protective role for the gene's activity.
"Since MC1R regulates pigmentation and red hair is a shared risk factor for both melanoma and Parkinson's disease, it is possible that, in both conditions, MC1R's role involves pigmentation and related oxidative stress," says Chen, an assistant professor of Neurology at Harvard Medical School. "Our findings suggest further investigation into the potential of MC1R-activating agents as novel neuroprotective therapies for PD, and together with epidemiological evidence, may offer information that could guide those carrying MC1R variants to seek advice from dermatologists or neurologists about their personal risk for melanoma and Parkinson's disease." Chen's team is continuing to pursue this line of research.
http://www.massgeneral.org/about/pressrelease.aspx?id=2067
Posted in: Medical Science News | Medical Research News | Medical Condition News
Tags: Brain, Cancer, Dermatology, Dopamine, Dopaminergic, Gene, Genetics, Hair, Health Care, HIV, HIV/AIDS, Hospital, Laboratory, Medical Imaging, Medical School, Melanoma, Mutation, Neurodegenerative Disease, Neurology, Neurons, Oxidative Stress, Parkinson's Disease, Receptor, Research, Skin, Skin Cancer, Skin Pigmentation, Stress, Stroke, Toxins, Tumorigenesis, X-linked
Researchers identify gene variant that protects against severe COVID-19
UniSA scientists make a surprising discovery in the origins of antibiotic-resistant gene
Olfactory receptor gene may play a role in breast cancer metastasis to the brain
New gene therapy addresses primary cellular deficit associated with limb-girdle muscular dystrophy 2B
Horizontal gene transfer between viruses and hosts plays a major role in driving evolution
Single-patient pilot study shows the ability of antisense oligonucleotide to suppress mutant ALS gene
New pioneering test helps predict the spread of deadly skin cancer
Defective gene in blood cancers could be treated with already available drugs
Positive childhood environments may help buffer the physiological effects of adversity and trauma
Neurology / Neuroscience
Virus-like particles as delivery vehicles for gene-editing


Sharon joined Alexander Beard Group in October 2018, having worked in the Financial Services industry for over 25 years. She started her career with Pearl Assurance in 1991 and has worked for HBOS and at two Chartered Financial Adviser firms based in Chester.
In November 2015, she qualified as an Independent Financial Adviser, providing advice to clients in all aspects of financial planning. Sharon holds the Diploma in Financial Planning (DIP PFS) and the Advanced Level Qualification in Pensions Planning and continues to work towards achieving her Chartered Financial Adviser status. She is also qualified to provide mortgage and Equity Release advice.
Sharon joined the Expat Division providing pension specialist advice to expatriates and will also advise UK based clients for the UK Financial Planning Division.


Laurie, life, etc...: 6 things every person should know, but don't.
6 things every person should know, but don't.
Who gives one person the right to dictate to another the way they should live their lives?
Who makes these people correct or proper?
Just because I ain't goin right, doesn't mean i'm going left either.
People need to get over themselves and get passed whatever it is thats eating at them.
Not everyone thinks the same as you.
I grew up with two sisters, we even slept in the same bed and we are the same, yet very different.
When I have an issue I always call them and get to very different views, sure we dont always agree, but we do see things in a different light.
No, you are not always right.
Just because something feels right for you, doesnt mean its right for that person or the situation.
Everyone is not your friend.
Not everyone is going to like you, even family members.
Yes, we have to love each other, but I never heard anyone saying I have to like each other.
unfortunately, everyone is doing their own thing and you just have to except that everyone has their own agenda.
Sometimes people are caught up and just aint interested, no matter how much you may need them, it just ain't their thing.
sometimes they are there for the long haul.


text:
Bicyclist hit by car, critically hurt
A bicyclist was hit by a car Friday evening in Newark and critically injured, authorities said.
The incident was reported just before 6 p.m. in the 600 block of S. College Ave.
New Castle County Paramedics found the bicyclist – identified only as a 23-year-old man – with possible head and back injuries, Paramedic Cpl. Abigail E. Haas said.
Paramedics treated him at the scene before he was transported to Christiana Hospital, where he was admitted in critical condition, she said.
Newark police are investigating.
No other information about the circumstances of the crash were immediately available.
Contact robin brown at (302) 324-2856 or rbrown@delawareonline.com. Find her on Facebook and follow her on Twitter @rbrowndelaware.


text:
Vernon woman's Indigenous work earns Order of Canada
Margo Greenwood, an Indigenous scholar of Cree ancestry, recognized with top honour
Jennifer Smith
Dr. Margo Greenwood has been named to the Order of Canada. (Contributed)
A local woman who worked for more than 30 years to transform the health and well-being of Indigenous children, families and community is being recognized with one of the highest honours in the land.
Dr. Margo Greenwood, an Indigenous scholar of Cree ancestry, has been appointed an Officer of the Order of Canada by Right Honourable Mary Simon, Governor General of Canada. This award acknowledges Greenwood's outstanding leadership and contributions to society.
Born in Wetaskiwin, AB, Greenwood resides in Vernon.
"I've been working in early childhood education since the start of my career. It's a calling that makes my heart sing," Greenwood said. "I'm accepting this award for my three sons who can see their contributions to our family realized, and for my granddaughter to see the full potential of women. I thank my Elders, teachers and colleagues who've advised and supported me in this journey."
She is the academic leader of the National Collaborating Centre for Indigenous Health, housed at the University of Northern British Columbia and is a professor in UNBC's First Nations studies and education programs. Greenwood has served as vice president of Indigenous Health, Northern Health since 2013.
For 15 years she has contributed to the Canadian Institutes of Health Research and was advisory board chair for the Institute of Aboriginal Peoples' Health from 2006-2013. She is currently a member of the Institute of Population and Public Health Advisory Board.
"The impact of Dr. Greenwood's ongoing work and leadership in education and research initiatives aimed at addressing Indigenous health inequities in B.C. and across Canada is immeasurable," said UNBC interim president Dr. Geoff Payne. "This prestigious honour is a testament to her unwavering commitment to ensuring that Indigenous Peoples' experiences, perspectives and knowledge are prioritized at provincial, national and international tables."
Greenwood says her work is driven by the question "how do we create systemic change in a world of injustice?" Her experience with Northern Health has further allowed her to lead such change.
Cathy Ulrich, Northern Health president and CEO congratulates Greenwood on the "well-deserved" recognition, on behalf of the board of directors and the many people she has mentored.
"Northern Health is very honoured and proud to have had Margo in our midst over the last eight years, and to have the opportunity to learn and improve as a direct result of her nationally- and internationally-recognized leadership and expertise," said Ulrich.
Greenwood was orphaned at the age of 16. She credits calling on the power of vision to open doors and overcome challenges in her journey. She reflects that, "As a child spending time outside on the land, I learned how to dream. And dreaming is hope."
"The National Collaborating Centre for Indigenous Health started as a dream at UNBC," notes Greenwood. "There were no road maps; we had to create something new. I drew on Elders, colleagues and friends from across the country to help this national centre unfold, evolve and thrive."
Greenwood co-authored General Comment #11 Indigenous Children and their Rights under the United Nations Convention on the Rights of the Child. She participated in the development of four federal Indigenous early childhood initiatives over the last two decades. She consulted with the Assembly of First Nations, most recently playing a key role in the creation of the First Nations Early Learning and Child Care Framework. It has been an honour, in all of this work, she says, "to articulate and hold up our collective dreams for Indigenous children and families anchored in Indigenous systems of knowledge where respect and relationships are at the core."
Greenwood completed her PhD in 2008. She has authored over 135 publications focusing on Indigenous peoples' health and well-being. She received the Queen's Golden Jubilee Award in 2002, and a National Aboriginal Achievement Award in 2011.
READ MORE: VIDEO: Stigma against Indigenous people a 'social sickenss'
READ MORE: Distinguished honour for Vernon Toastmaster
@VernonNews
newsroom@vernonmorningstar.com
IndigenousOrder of Canada
'Immediate need' for blood donations during holiday season
Fire on board Canadian warship could have been avoided: Navy commander


text:
Q: Sticky Notes for a Dual-Booted Setup Is there a way for me to "sync" desktop-like sticky notes across my Windows and Ubuntu partitions?
I saw that there are Google Drive options, but IMO, Google Drive uses too much memory and I hate memory drags.
I also found http://www.cloudstickynotes.com/, but it seems kind of sketchy and unprofessional.  Does anyone have experience with it?
Best


text:
cask "calibre" do
  if MacOS.version <= :high_sierra
    version "3.48.0"
    sha256 "68829cd902b8e0b2b7d5cf7be132df37bcc274a1e5720b4605d2dd95f3a29168"
    url "https://download.calibre-ebook.com/#{version}/calibre-#{version}.dmg"
  else
    version "5.17.0"
    sha256 "365cb8b8c7428dadb60027d1b984e9ff24a826bec66c9bca963e2340271fa05f"
    url "https://github.com/kovidgoyal/calibre/releases/download/v#{version}/calibre-#{version}.dmg",
        verified: "github.com/kovidgoyal/calibre/"
  end

  name "calibre"
  desc "E-books management software"
  homepage "https://calibre-ebook.com/"

  conflicts_with cask: "homebrew/cask-versions/calibre4"

  app "calibre.app"
  binary "#{appdir}/calibre.app/Contents/MacOS/calibre"
  binary "#{appdir}/calibre.app/Contents/MacOS/calibre-complete"
  binary "#{appdir}/calibre.app/Contents/MacOS/calibre-customize"
  binary "#{appdir}/calibre.app/Contents/MacOS/calibre-debug"
  binary "#{appdir}/calibre.app/Contents/MacOS/calibre-parallel"
  binary "#{appdir}/calibre.app/Contents/MacOS/calibre-server"
  binary "#{appdir}/calibre.app/Contents/MacOS/calibre-smtp"
  binary "#{appdir}/calibre.app/Contents/MacOS/calibredb"
  binary "#{appdir}/calibre.app/Contents/MacOS/ebook-convert"
  binary "#{appdir}/calibre.app/Contents/MacOS/ebook-device"
  binary "#{appdir}/calibre.app/Contents/MacOS/ebook-edit"
  binary "#{appdir}/calibre.app/Contents/MacOS/ebook-meta"
  binary "#{appdir}/calibre.app/Contents/MacOS/ebook-polish"
  binary "#{appdir}/calibre.app/Contents/MacOS/ebook-viewer"
  binary "#{appdir}/calibre.app/Contents/MacOS/fetch-ebook-metadata"
  binary "#{appdir}/calibre.app/Contents/MacOS/lrf2lrs"
  binary "#{appdir}/calibre.app/Contents/MacOS/lrfviewer"
  binary "#{appdir}/calibre.app/Contents/MacOS/lrs2lrf"
  binary "#{appdir}/calibre.app/Contents/MacOS/markdown-calibre"
  binary "#{appdir}/calibre.app/Contents/MacOS/web2disk"

  zap trash: [
    "~/Library/Caches/calibre",
    "~/Library/Preferences/calibre",
    "~/Library/Preferences/net.kovidgoyal.calibre.plist",
    "~/Library/Saved Application State/com.calibre-ebook.ebook-viewer.savedState",
    "~/Library/Saved Application State/net.kovidgoyal.calibre.savedState",
  ]
end


The definition of the const_bnd_elem_iterator struct.
It is similar to the regular iterator above, but also provides an additional conversion-to-const ctor.
Definition at line 1262 of file MooseMesh.h.
Definition at line 1269 of file MooseMesh.h.
Definition at line 1279 of file MooseMesh.h.


text:
Die Alte Apotheke in Garmisch ist ein Gebäude im Markt Garmisch-Partenkirchen in Oberbayern. Das Haus ist auf Basis des Denkmalschutzgesetzes vom 1. Oktober 1973 ein Baudenkmal, die Akten-Nummer lautet D-1-80-117-178.

Beschreibung
Die Alte Apotheke ist ein stattliches, im Empire-Stil italienischer Prägung erstelltes Gebäude. Das Patrizierhaus besitzt ein gebrochenes Walmdach, große Zwerchgiebel und Empiredekor. In seiner völligen Abweichung zur ansonsten eher bodenständigen Bebauung zählt es zu den Wahrzeichen des Garmischer Marienplatzes. Erbaut wurde es im Jahre 1792 an Stelle der Dorfschmiede. Entworfen hat das Gebäude der Nürnberger Architekt Imhoff, Bauherr war der wohlhabende Kaufmann Johann Jakob Mayr (1734–1797). Die reiche innere und äußere Verzierung des Hauses erstellten Stuckateure aus Italien.

Im Jahre 1822 eröffnete der Augsburger Arzt und Apotheker Jakob Byschl im Gebäude eine Apotheke. Mehr als ein Jahrhundert blieb die Apotheke in Familienbesitz. 1929 verkaufte sie Max Byschl aus gesundheitlichen Gründen an Ludwig Ryhiner, der das Gebäude umfassend renovieren ließ. Am 1. Oktober 1959 übernahm der Münchner Walter Imhoff die Apotheke in Pacht, später ging sie in seinen Besitz über. Heute wird sie in der dritten Generation von Verena Bockhorni geleitet.  Zahlreiche pharmazeutische Gerätschaften wie Mörser, Waagen, bauchige Gläser, bemalte Fayencen, Salbengefäße, kunstvoll gearbeitete Schränke und Rezepturtische in den Räumen der Apotheke zeugen immer noch von der Vergangenheit des Gebäudes.

Siehe auch
 Liste der Baudenkmäler in Garmisch-Partenkirchen

Weblinks

Einzelnachweise

Baudenkmal in Garmisch-Partenkirchen
Garmisch
Bauwerk in Garmisch-Partenkirchen
Unternehmen (Garmisch-Partenkirchen)

redpajama_set_name: RedPajamaWikipedia