The Fertile Valley Baseball League's (FVBL) regular season is drawing to a close and the undefeated Kindersley Stallions are poised atop the league and their division.
The Stallions are 11-0 with two games remaining, although if one of the games is not made up, the team only has one game left to play on the schedule. The Stallions are away in Elrose tomorrow night for a game against the Aces starting at 7 p.m. The Aces are tied for first in the East division with a record of 6-3.
In the Stallions' last three games, the team earned wins of 8-0 over the Kindersley Royals on June 22, 5-4 over the Rosetown Angels on June 23 and a 17-3 drumming of the Eatonia Wheat Kings in Kindersley on June 29.
The Kindersley Raiders are second in the West division behind the Stallions with a record of 8-2. The Raiders earned a convincing win over the Wheat Kings in their game on Monday by a final score of 11-2. Byron Ismond pitched well to earn the win, a win that included a six-run fourth inning for the Raiders.
The Raiders only have one game remaining on their schedule, a game tomorrow night against the rival Angels in Rosetown starting at 7 p.m. The Raiders and Angels have played in the FVBL final three years in a row with the Angels winning the title in two of those years.
At the opposite end of the West division standings are the Kindersley Klippers, Kindersley Royals and the Wheat Kings. The Klippers at 2-6 on the season were scheduled to play the Kyle Yellow Jackets last night in Kyle.
For more on this story, please see the July 6 print edition of The Clarion.


text:
/*jshint globalstrict:false, strict:false, unused : false */
/*global assertFalse, assertEqual */
////////////////////////////////////////////////////////////////////////////////
/// @brief tests for transactions
///
/// @file
///
/// DISCLAIMER
///
/// Copyright 2010-2012 triagens GmbH, Cologne, Germany
///
/// Licensed under the Apache License, Version 2.0 (the "License");
/// you may not use this file except in compliance with the License.
/// You may obtain a copy of the License at
///
///     http://www.apache.org/licenses/LICENSE-2.0
///
/// Unless required by applicable law or agreed to in writing, software
/// distributed under the License is distributed on an "AS IS" BASIS,
/// WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
/// See the License for the specific language governing permissions and
/// limitations under the License.
///
/// Copyright holder is triAGENS GmbH, Cologne, Germany
///
/// @author Jan Steemann
/// @author Copyright 2013, triAGENS GmbH, Cologne, Germany
////////////////////////////////////////////////////////////////////////////////

var db = require("org/arangodb").db;
var internal = require("internal");
var jsunity = require("jsunity");

function runSetup () {
  'use strict';
  internal.debugClearFailAt();

  db._drop("UnitTestsRecovery");
  var c = db._create("UnitTestsRecovery"), i;
  internal.wal.flush(true, true);
  internal.wal.properties({ throttleWait: 1000, throttleWhenPending: 1000 });

  for (i = 0; i < 10000; ++i) {
    c.save({ _key: "test" + i, value1: "test" + i, value2: i });
  }

  internal.debugSetFailAt("CollectorThreadProcessQueuedOperations");
  internal.wal.flush(true, false);

  // now let the write throttling become active
  internal.wait(7);
  try {
    c.save({ _key: "foo" });
  }
  catch (err) {
  }

  internal.debugSegfault("crashing server");
}

////////////////////////////////////////////////////////////////////////////////
/// @brief test suite
////////////////////////////////////////////////////////////////////////////////

function recoverySuite () {
  'use strict';
  jsunity.jsUnity.attachAssertions();

  return {
    setUp: function () {
    },
    tearDown: function () {
    },

////////////////////////////////////////////////////////////////////////////////
/// @brief test whether we can restore the data
////////////////////////////////////////////////////////////////////////////////

    testWriteThrottling : function () {
      var i, c = db._collection("UnitTestsRecovery");

      assertEqual(10000, c.count());
      for (i = 0; i < 10000; ++i) {
        var doc = c.document("test" + i);

        assertEqual("test" + i, doc.value1);
        assertEqual(i, doc.value2);
      }

      assertFalse(c.exists("foo"));
    }

  };
}

////////////////////////////////////////////////////////////////////////////////
/// @brief executes the test suite
////////////////////////////////////////////////////////////////////////////////

function main (argv) {
  'use strict';
  if (argv[1] === "setup") {
    runSetup();
    return 0;
  }
  else {
    jsunity.run(recoverySuite);
    return jsunity.done().status ? 0 : 1;
  }
}

redpajama_set_name: RedPajamaGithub


text:
Q: Why do some types (e.g. Float80) have a memory alignment bigger than word size? To make it specific, I only want to know why on my 64 bit mac, the Swift compiler says the alignment of some types like Float80 is 16.
To check the memory alignment requirement of a type, I use the alignof function.
sizeof(Float80) // ~> 16 bytes, it only needs 10 bytes, but because of hardware design decisions it has to be a power of 2
strideof(Float80) // ~> 16 bytes, clear because it is exact on a power of 2, struct types with Float80 in it, can be bigger
alignof(Float80) // ~> 16 bytes, why not 8 bytes, like String ?

I understand the memory alignment of types less or equal the size of the word is beneficial.
sizeof(String) // ~> 24 bytes, clear because 24 is multiple of 8
strideof(String) // ~> 24 bytes, clear because 24 is multiple of 8
alignof(String) // ~> 8 bytes, clear because something greater or equal to 8 bytes should align to 8 bytes

Many types with a bigger memory size footprint like String (with a size of 24) does have a memory alignment requirement of 8 bytes. I expect that is the size of my CPU/RAM bus in use, because I have a 64 bit mac and os.
I check the size of the type without the last padding with the sizeof function and with the adding padding to the end with the strideof function (strideof is more helpful in arrays of structs, Swift then adds bytes to the end to reach the next multiple of the alignment requirement.)
I understand that padding is necessary for types lesser or equal than the size of 8 byte.
But I don't understand why it is advantageous to have a memory alignment requirement bigger than 8 bytes on my 64 bit mac.
Float80 needs 80 bits for its value, that are 10 bytes, with 6 filler bytes.
Here is an image to make it more clear, what I mean.
The green positions are allowed for a Float80, the red positions not.
The memory is in 8 byte chunks in this picture.

A: All "primitive data types" (the term may be wrong, what I mean is the
data types that are used by the processor) have a "natural boundary",
and the compiler will align them in memory accordingly. The alignment
depends on the processor (e.g. x86 or ARM) and the programming environment (e.g. 32-bit vs 64-bit).
Some processors allow misaligned data (perhaps at a lower speed),
and some do not allow it.
For the 64-Bit Intel architecture, the requirements are listed in
Data Alignment when Migrating to 64-Bit Intel® Architecture:

The 64-bit environment, however, imposes more-stringent requirements on data items. Misaligned objects cause program exceptions.
  [...]

*

*Align 8-bit data at any address

*Align 16-bit data to be contained within an aligned four-byte word

*Align 32-bit data so that its base address is a multiple of four

*Align 64-bit data so that its base address is a multiple of eight

*Align 80-bit data so that its base address is a multiple of sixteen

*Align 128-bit data so that its base address is a multiple of sixteen

So the alignment is not necessarily equal to the "word size", it can be
less or more. Float80 corresponds to the "Extended Precision"
floating point type of the x86 processor, and its alignment is
required to be 16 bytes.
Composite types like C struct are layed out in memory such that
each member is on its natural boundary (and padding is inserted
in between if necessary). The alignment of the struct
itself is the largest alignment of each member.
The memory layout of a Swift Struct is not documented officially (as far as I know) but it is probably be similar to the C struct.
Here is a simple example:
struct AStruct {
    var a = Int32(0)
    var b = Int8(0)
    var c = Int16(0)
    var d = Int8(0)
}
println(sizeof(AStruct))     // 9
println(alignof(AStruct))    // 4
println(strideof(AStruct))   // 12

The memory layout (probably) is (* = padding):
aaaab*ccd

Here the alignment is 4 because that is the required alignment for Int32. The struct occupies 9 bytes, but the "stride" is 12:
This guarantees that in an array of structs all elements satisfy
the same alignments.
(Note that the Swift strideOf() corresponds to the C the sizeof() function, this is explained in https://devforums.apple.com/message/1086107#1086107.)
The declaration of a  Swift string shown as
struct String {
    init()
}

but the actual members are not visible to us mere mortals.
In the debugger it looks like this:

which indicates that its members are a pointer,
an unsigned word and another pointer. All these types have a size and
alignment of 8 bytes on 64-bit. This would explain the size (24 bytes)
and alignment (8 bytes) of struct Swift.

A: With the help of Martin R's link and the hint that it is a processor design decision. I found the readon why.
Cache lines.
Cache lines are a very small memory for the processor, on the Intel Mac 64 bit of mine it is 128 bit (16 bytes).
As seen in the picture of the question I knew there was a difference between the dotted and the bold lines. The bold lines are between the cache lines of the processor. You don't want to load 2 cache lines if you could do better with a little more memory cost. So if the processor only allows, that types with a size of 8 bytes (or bigger) are aligned on the start of a cache line (every multiple of 16). There will be no two cache line reads for a type that is as big as a cache line (double the word size im my case, 16 bytes). As you can see in the picture only the red blocks are crossing the bold line (so they are not allowed per design).
See the link attached for more info.
Cache effects

redpajama_set_name: RedPajamaStackExchange


42" round wood patio table w/ 2 chairs in good condition. Table measures 42" round x 30" tall. Table top has hole from umbrella and some damage to wood around hole as seen in pics. Each chair measures 16" wide x 20" deep x 33" tall, 18" seat height.
Click the button below to add the 42" Wood Cafe Patio Table w/ 2 Chairs to your wish list.


text:
Follow @esnoticiaco
Luffy wrote this story and was read by 233 people. For free.
Mom s stress may put kids at risk for autism
29.17% credibility
Luffy for
Which banana would you choose? Your response may affect your health
Can you spot the animal in the picture?
4 Super-Quick breakfasts you can make at the office
Health at home
George HW Bush s World War II love letter to Barbara Bush goes viral
You have to know
5 Reasons why you re gaining weight that have nothing to do with food
Futurity- Women who experience stress during pregnancy and have a stress-sensitive gene are more likely to give birth to a child with autism, researchers have discovered.
The finding could be a step toward helping identify women who have greater risks for having children with autism when exposed to stressors during a specific time window during their pregnancy.
"Autism was thought to be largely a genetic disorder, but previous research has shown that environmental influences such as stress can play an important role in the development of the condition," says David Beversdorf, associate professor of radiology, neurology, and psychological sciences at the University of Missouri.
"We know that some mothers who experience significant levels of stress don't have children with autism, but others do. To help understand why, we studied a gene that is known to affect stress and found a link between it and the development of autism with exposure to stress."
For a new study, published in Autism Research, scientists looked at two groups of mothers of children with autism spectrum disorder. The mothers were surveyed about stress during their pregnancy, such as loss of a job, moving, or divorce. The mothers' blood was tested for a variation of the stress-sensitive gene known as 5-HTTLPR, which regulates the neurotransmitter serotonin in the nervous system. When a variation of the gene is present, the availability of serotonin is altered, causing an increased reaction to stress.
In both groups, mothers of children with autism who have the variation of the stress-sensitive gene reported experiencing more stress during the end of the second and the beginning of the third trimester of pregnancy, compared to mothers who did not carry the altered gene.
"Though this was an observational study and future confirmation of this finding is needed, it's possible we could, one day, identify women who may be at a greater risk of having a child with autism when exposed to stress," Beversdorf says.
"More research is needed to understand the mechanisms of how this gene-stress interaction works, but hopefully this could someday help prevent some cases of autism."
Other researchers from the University of Missouri and from Queen's University, Central Methodist University, and Massachusetts General Hospital for Children are coauthors of the study.
Fuente: www.futurity.org
To comment you must log in with your account or sign up!
Paralyzed designer creates jeans for women in wheelchairs
¿Giran los planetas habitados más deprisa?: La...
Happy couples downgrade other people s hotness
The natural and good way to burn fat
Chinese company unveils fully-functional 3D-printed villas that can...
Employee Takes Photo Wearing The Store's Clothes. What Her Boss...

redpajama_set_name: RedPajamaCommonCrawl


So now I have this "great" idea for a show….I have to write a script!? Ack! I have no clue how to do that!! I mean, what with work an everything, how am I going to find the time. Though it will definitely take a lot less time to get ready than a Psychotaku episode just based on the lack of translation. Thank goodness. And Justin is coming out soon for E3 so it means I at least have to have a "gakuran" episode written by then!!!
Previous Psykoneko Blog….GO!!! Next A weekend of Wrestling fun!


Six rescuers tried to save the Apollo 1 astronauts from a suffocating, fiery death. My grandpa was one of them.
Motherboard exclusively premieres Roger Goula's new single from Overview Effect-inspired album.
Lunar Orbiter 1 snapped the original "Earthrise" shot.
"Yes they do let women do some things at NASA. And it's not because we wear skirts."
Are you in the market for 15 gilded astronaut hand molds?


text:
Церква святого великомученика Юрія Переможця — парафія і храм Заліщицького благочиння Тернопільської єпархії Православної церкви України в селі Касперівці Чортківського району Тернопільської області.

Історія церкви
Храм збудовано у 1619—1650 роках з мурованим престолом, у який вставлено плиту з написом «1650 р.». Над притвором знаходилася двоярусна оборонна башта, від якої залишився нижній ярус. Апсида ззовні укріплена трьома потужними контрфорсами. Первісні перекриття не збереглися. Храм з часом дещо деформувався. Це пов'язано з низьким фундаментом — всього у 25 см. Існують перекази, за якими Богдан Хмельницький, здійснюючи свої походи, У радянські часи приміщення храму використовували під музей. Покрівлю зруйнували. У 90-і роки завдяки наполегливості парафіян села Містечко, яке налічувало 65 дворів, розпочали відновлення храму, намагаючись не порушити давню конструкцію та старовинний стиль.

На одній із стін залишився давній розпис. Відреставровано покрівлю, яка протрималася недовго через непрофесійність майстрів та некондиційні гонти, що призвело до протікання.

У 2002 році споруду перекрито бляхою та добудовано притвор.

Завдяки церковному братству та сестринству, зокрема, Михайлу Трифою, Роману Мшевичу, Павлу Вітюку та всіх парафіян с. Містечко храм відновлено. Незважаючи на вік, церква продовжує приймати молитви віруючих парафіян та задовольняти їх духовні потреби.

Парохи
 о. Володимир П'єцух (з березня 1992).

Джерела

Церкви Чортківського району
Касперівці
Церкви Святого Юрія

redpajama_set_name: RedPajamaWikipedia


These horizontal PCB mounting, panel-mount, 6.35mm jacks offer high packing-density by mounting on 15.88mm minimum centres in rows or arrays. They are available in mono and stereo versions with switching and non-switching contacts. Metal thread versions provide EMC protection grounding connections.
There are five mounting-nut options, which should be ordered separately as required. Connectors are supplied without nuts.


"Booking what?!" - you might ask exasperated and you would not be the only hotelier to do so.
Booking.com has quietly introduced a new rate option, called Booking.basic that displays cheaper inventory from other OTAs on their own site. The emphasis is on quietly as many hotel managers yet to hear about this release. There was no public announcement - just a quick switch of a button and customers can now reserve heavily discounted rates on the biggest 3rd party platform.
While Booking.basic still appears to be in a preliminary phase, it is sign of a tumultuous trend that has been tormenting the travel industry for years.
What exactly is Booking.basic? In addition to offering its own inventory, Booking.com now presents rates from other online travel agencies. When travellers search for a hotel, a special tier may appear above the property's regular rates. This happens if the rate supplied to Booking.com is not the cheapest available online.
An orange and black badge clearly indicated that this is a unique option. Since inventory is pulled from elsewhere, sometimes it takes a few extra seconds for this rate to appear on the page.
The room's supplier is not immediately visible to guests - it is only revealed to after the booking have been completed. After some investigative work, industry experts identified Agoda and Trip.com (formerly known as CTrip) as the third party partners supplying Booking.com with discounted inventory. Both businesses are owned by or linked to Booking Holdings, that just happens to be Booking.com's parent company.
Booking.basic is elusive. It was first spotted in the summer of 2018 for properties based in Asia, then slowly released in Europe towards the end of last year.
There is no option to search specifically for this rate so it is challenging to track it. As an added twist, users browsing from the same location at the same time may be presented with different options.
During our own research, we have spotted several premium city hotels with Booking.basic rates in the UK and Ireland as well as across other popular European destinations. If you would like check it for yourself, try searching for a low demand rate in a major city in Europe, select deals from the filter and you will likely spot a Booking.basic rate amongst the first 10-15 hotels.
You may not even be aware that your hotel has Booking.basic rates listed because confirmation would come from another 3rd party site.
Interestingly, while Booking.basic is cheaper than the supplied Booking.com rate, it is not necessarily the lowest online rate for that hotel on a certain date. This probably due to the fact that the OTA only works with selected partners.
Guests are always looking for the cheapest rates so it would be fair to assume that Booking.basic is good news for them. But is it?
Booking.basic rates are restricted by rigid terms and conditions that can be easily missed by less tech-savvy travellers.
Accommodation must be prepaid and customers are charged immediately.
In case of no-show, cancellation or amendment, customers will not be refunded.
As a special price, Booking.basic will only appear at selected hotels on specific dates.
Prices changes quickly as inventory is provided by wholesalers.
Receiving a confirmation email may take up to 24 hours.
The property may not accept the booking (in this case, money is refunded within 24 hours).
Bed type might be selected by the property.
No invoice can be requested for these reservation.
Booking.com is gambling with its brand name as irate guests may turn away from their platform.
"Booking.com will take your money and refuse to help you. Unless you don't mind not knowing if you have a room or not, I would never book this option." - wrote one traveller on an online forum.
"We book with Booking.com because we trust them. I certainly wouldn't book with CTrip on purpose." - said another one.
Of course, hoteliers may also run into guest relations issues as they need to answer questions from confused callers.
How is a hotel selected for inclusion? It all appears to be based on the hotel's Price Quality Score (PQS) - a determination used by Booking.com to see how attractive a property's rates are to customers. With other words, if you offer much cheaper rates on other 3rd party sites, Booking.com will try to make sure that they are bookable on their channel too.
Travel news sites cite hoteliers who have been advised by the OTA giant if their PQS falls under 70 out of 100, they will qualify for Booking.basic listing. But information is scarce and confusing.
Management of Booking.basic is entirely within the OTA's power. Hoteliers can do little to nothing to put a stop to it. While Booking.com is eager to portray itself as a hospitality partner, the serious lack of consultation (or even information) points away from that image.
So can we lay all the blame at the door of the OTA's Amsterdam head office? No quite.
Managing rate parity has become a mammoth task for hotel managers in recent years. Wholesale prices that were never intended to be sold to the public routinely appear in online searches. The key difference is that now not only no-name sites offer unauthorised rates but leading brands such as Booking.com and Expedia. With the Add-On Advantage Program, Expedia too enabled customers to book discounted hotels after they purchased their airfare.
After all, these businesses just take advantage of existing industry flaws. Can we really condemn them to want to maximise their own revenue?
The only way out from this mess is to demand stricter conditions from wholesale partners. Hotels must penalise them if industry rates are sold on to the public without permission. While monitoring rates is a time-consuming and thankless task, it is now an essential one. Industry experts also agree that dynamic packaging as opposed to static rates can also combat this trend.
Hotels must live up to their best rate promise - otherwise consumer trust will be lost and their direct strategy will suffer irreversible damages.


Wow it's Thursday, where has this week gone.
Let's have a look at a few number that count….
9 hsut, cracked a perfect 9 which was quite amazing as he was the only one whilst 100's people got 8. You would have thought a few more may have pulled a 9 off. Well done hsut. I look forward to catching up with you and finding out the mystery of that name.
4 home games and only 1 win against GWS. Whilst they have won every game on the road and they were agains Geelong at Geelong West Coast and Bulldogs. What is going on Sydney, I feel so sorry for your home fans coming out to watch.
1 couple of 1 game suspensions this week. 1 that should have got more and 1 that should not have got any. What are your thoughts? Let me know.
61 I am dismayed at what is going on with GWS, I feel like for the first time that maybe the coaching staff need to look at themselves. GWS should not be getting a 61 point flogging anywhere.
6 & 7 normally it's a stairway to heaven but the Bombers they like building a stairway to hell. Have a look at their charts the past 2 rounds after being infront by 6 points and 7 points in their last 2 games they have have had such similar results.
42 pts drubbing which was pretty sad to see. One side you could say that it was good that the Eagles finally won a game against a quality side in Port, but now all the experts are starting to doubt whether Port are a quality side. Lets hope they can turn it around in 2 weeks time!
5 The Crows did what they should have I guess against their feeder side. Only sad thing about this game is that there didn't seem to be any recruits left for Adelaide to pick up next year. Was great to se McGovern come out with his best game this year kicking 5.
Round 8 starts tomorrow so catch you again then.


text:
"I'm on a Different Wavelength": Domo Genesis is Happy Again (Interview)
Posted On : January 31, 2018 Published By : Alicia Moore
Domo Genesis stands behind the stage right entrance. He's waiting for his cue to emerge before the crowd at the release party for good friend and collaborator Evidence's new album, Weather or Not. Every soul in LA's sold-out Roxy Theatre is eagerly anticipating Domo's performance, but the Inglewood rapper shows not a trace nervousness. Instead, he shares a laugh with the man standing next to him. Finally, the DJ deems the audience ready for Domo's entrance, and the man before the man the hour saunters his way to center stage, passionately rapping the words to "Brake" f his week-old mixtape Aren't U Glad You're U?.
Two years ago, the concept sharing his solo material with the world wasn't nearly as nonchalant, especially in the days leading up to the release Genesis, Domo's debut solo album.
"Genesis had me with the jitters. Of course, it's the first one," he says candidly during our green room interview a few hours before the show. "It's a lot shit that I got out the way, a lot shit that I learned. Being able to kick it with people, like Ev, who's been doing this for a long time, and soak in knowledge, I became a whole other person."
Domo and Evidence originally met at the house legendary producer The Alchemist, when Domo and Alc were working on their joint 2012 mixtape No Idols. Evidence (and many others) would ten stop by the house to play their new music, and the two quickly hit it f. That friendship would eventually blossom into the collaboration "Deez Nuts" f Domo's 2017 mixtape Red Corolla, and the song's excellent response convinced the two to record an entire project together, which became Aren't U Glad You're U?.
"It was supposed to be five songs originally, but me and Ev had such a sick relationship doing this, everything about it was organic," he says. "It was just cool to work freely with somebody like that and have them critique what you're doing, or tell you to have more conviction. So it ended up being a little bit longer, just because it was something that was fun to do."
The two originally planned to release Aren't U Glad You're U? immediately following Red Corolla, but as things began to fall into place, dropping the mixtape in early 2018 became the only sensible option. As the release date for Evidence's album drew near, Domo kept his accomplice's best interests in mind, and ultimately decided to release his own tape close to Evidence's full-length in order to further build anticipation.
"I wanted to drop my mixtape] to promote his album, to show love to Ev," Domo says. "I knew he had a lot things going on, like Defari's Rare Poise] tape, so he had a lot that was running his momentum up. So I was just like, 'Why not put it out a week before and then have you drop yours?' and it seems like it really picked up that way."
Getting his debut album out the way played a major role in Domo's decreased nerves leading up to Aren't U Glad You're U? but it was a return to his inherent sound that also put him at ease. The rapper enjoyed experimenting with live instrumentation for the first time on Genesis, but his hip-hop upbringing made the beat-tape atmosphere he crafted on the new mixtape a much more natural setting.
"It's what I'm familiar with, the music I listened to when I was a kid that got me into rap," he says. "I don't dislike working with a big band either—those have been some my favorite songs, but it doesn't give you that same nostalgia, those feelings you got when you were first bumping Late Registration."
Nostalgia drives Domo in more ways than one; certainly encouraging his affinity for the beat machine, but also inspiring his songwriting as he tries to relive memories from years past.
"I'll hear a beat, and I'll be like, 'Oh, this reminds me what I was doing in high school when I was driving around throwing eggs at people,'" he says with a laugh. "That's the kind shit that inspires me, I'll go back in the moment and try to base this song f that experience."
Domo isn't entirely fond Memory Lane, however; for quite some time following the release Genesis, personal struggles outside music stood in the way creating the necessary drive to create and release new material. He credits family and friends for motivating him to push through and delivering constructive criticism, which he believes helped to give him the confidence to share more his creations with the world.
"A lot people that I keep around me, they genuinely care," he says. "They'll tell me stuff in a negative way, but for positive reasons. Like, 'You're not doing this, I know you Doms. What's going on?' You know, like when your uncle punch you in your chest when you're little, it's like that."
Through all the ups and downs, Domo feels he has arrived at a better place. He is unhindered from a workflow, which has allowed him to attack the new year with the underdog mentality he's grown accustomed to owning. His goal for 2018 is to sustain a more consistent output, whether it be new albums, mixtapes, or visuals.
"It takes a lot time to get inspired by real life to go back and rap," he says. "Once you get past that and you're in a happy place, you're in the mood to just work. I'm on a different wavelength. Now it's just fun to be in a place where I can just talk about life and have fun doing it."
Posted in: ALTERNATIVE ROCKTagged : happy,hea,love,No,party,personal,rap,writing
Brooklyn Rapper Skyzoo Talks 'In Celebration of Us,' 'Black Panther' Excitement and His Own Marvel Future
Kodak Black ft Jackboy, John Wick – Broward Paradise


The first poem in Gottfried Benn's first book, Morgue (1912) - written in an hour, published in a week, and notorious ever after, or so the poet claimed - with its scandalous closing image of an aster sewn into a corpse by a playful medical student, set him on his celebrated path. And indeed, mortality, flowers, and powerful aesthetic collisions typify much of Benn's subsequent work.
Over decades, as he suffered the vicissitudes of an often hostile fate - the death of his mother from untreated cancer; the death of his first wife Edith in 1922; his brief but disastrous attempt to ingratiate himself with the Nazis in 1933, followed by their persecution of him; the suicide of his second wife Herta in 1945, afraid she would fall into the hands of the Russians - the harsh, sometimes callous voice of the poems relented, softened, and mellowed. The later Benn - from which Impromptus is chiefly drawn, many of the poems translated into English for the first time - is deeply affecting: the routines and sorrows and meditations of an intelligent, pessimistic, and experienced man. Written in what T. S. Eliot called the 'third voice' of poetry, the low un-upholstered monologue of the poet talking to himself, these poems are slender ribbons of speech on the naked edge of song and silence.
With this new collection of poems selected and translated by Michael Hofmann, Gottfired Benn, at long last, promises to attain in English the presence and importance that he so richly deserves.
The first poem in Gottfried Benn's first book, Morgue (1912) - written in an hour, published in a week, and notorious ever after, or so the poet claimed - with its scandalous closing image of an aster sewn into a corpse by a playful medical student, set him on his celebrated path. And indeed, mortality, flowers, and powerful aesthetic collisions typify much of Benn's subsequent work.Over decades, as he suffered the vicissitudes of an often hostile fate - the death of his mother from untreated cancer; the death of his first wife Edith in 1922; his brief but disastrous attempt to ingratiate himself with the Nazis in 1933, followed by their persecution of him; the suicide of his second wife Herta in 1945, afraid she would fall into the hands of the Russians - the harsh, sometimes callous voice of the poems relented, softened, and mellowed. The later Benn - from which Impromptus is chiefly drawn, many of the poems translated into English for the first time - is deeply affecting: the routines and sorrows and meditations of an intelligent, pessimistic, and experienced man. Written in what T. S. Eliot called the 'third voice' of poetry, the low un-upholstered monologue of the poet talking to himself, these poems are slender ribbons of speech on the naked edge of song and silence.With this new collection of poems selected and translated by Michael Hofmann, Gottfired Benn, at long last, promises to attain in English the presence and importance that he so richly deserves.


text:
const crypto = require('crypto');

// uuid generator for creating unique branch names.
module.exports = () => {
  const id = crypto.randomBytes(16).toString('hex');
  return id;
};


text:
Q: Как прервать исполнение функции Допустим у меня есть функция func, которая слушает ответ от сервера.
Я хочу сделать так чтобы допустим если эта функция выполнялась дольше секунды, то прервать ее исполнение, это прерывание я хочу реализовать в отдельном потоке
Вопрос: как мне это сделать?


Make-A-Wish® has photos, videos, and PSAs that can be made available for media use upon request.
To make a request, email Jamie Sandys, Senior Manager, Brand Communications and PR, at wfnaqlf@jvfu.bet. Please include information stating the desired assets as well as basic information explaining the usage and potential exposure of the assets. Permission to access the desired assets will be granted on a case-by-case basis. If this is an urgent request (i.e material needed within 48 hours), please call 602.385.6884.


WELLSEE WS-IC800 800W portable power adapter_High Frequency Inverter_Products_Physical therapy,health product,therapeutic apparatus,Electro Acupuncture,Medical Supplies are best selling on our website!
5.Wellsee inverters will stop working automatically when overheating or overloading, and start again automatically when the condition returns to normal.
8.WS-IC800 800W adopts an aluminum alloy casing with a beautiful shape and the technique of a high pressure plasma oxidation surface with high hardness and oxidation resistance.
portable to use, thank you!
Hello, we need 1800W. Do you have that type ?


text:
ACKS First Impressions
Adventurer Conqueror King System is a dialect of B/X D&D with highly elaborated endgame and domain rules. As such, it is easy to lift elements from it into other similar games, even if you don't want to play it all as written. There is a lot to like here. It would be easy for anyone familiar with basic D&D to jump in and be able to play based on their knowledge of that game. In some ways, it is even closer to Moldvay than Labyrinth Lord. But it does not idealize an old school feel. Would I play this game straight, either as a referee or as a player? Without the proficiencies, absolutely. Also, I realize that this is a silly and subjective thing, but I like that they refer to the referee as a Judge rather than inventing yet another title for the Dungeon Master.
ACKS goes out of its way to provide a modern facade while maintaining a classical essence. It has actually retained many of the most controversial aspects of old school D&D, such as race as class, but the essence is obscured because there are multiple classes for each demihuman race. For example, there are two elf classes available: the spellsword (fighter/mage, basically the traditional B/X elf) and nightblade (thief/mage). These classes are only available to elves, and are also the only classes an elf may choose. This retains the special demihuman flavor provided by race as class while sidestepping the issue of why elves can't be thieves (or whatever). And all classes have level limits (ranging between 10 and 14). This is how I would play B/X, it just makes the human level limit explicit, and softens the level limit blow by not including any classes with extremely low level limits (like the B/X halfling, which only shows up as a monster). I think this design is masterful.
Another example is that many resolution mechanisms have been replaced with a d20. Elves detect secret doors by casual inspection on 14+ (i.e., 35%). That's close enough to the d6 roll in B/X to be functionally the same, though it is phrased as a proficiency check. Thieves use d20s for their skills. I prefer d6 checks, but I realize that this is a cosmetic thing. Interestingly, they seem to have been much more consistent about "modernizing" the player-facing rolls than the referee rolls. For example, surprise and monster reaction still use the d6.
There are many other cases of classic game mechanics. Save or die poison. 1 in 8 chance of encountering a dragon on many of the wilderness random encounter tables. Does that sound familiar to anyone else? It is from page 18 of The Underworld & Wilderness Adventures. There are five saving throws and they vary by level (even though there are no death rays).
One more example of this kind of updating, regarding doors in dungeons from page 93:
Some dungeons are so drenched in evil that the doors themselves are antagonistic. Such evil doors automatically swing shut when released unless spiked or wedged open. Evil doors always open easily for monsters, unless the door is spiked shut, held firm, or magically closed.
That is a wonderful way of making the original rules for doors acceptable to a modern audience. Someone familiar with the old rules will nod knowingly, while someone encountering this for the first time might just think it is fun and creepy.
Some notes on spell casting. Mages work like 3E sorcerers; no spell preparation is required. They have spells in both their repertoire (immediately accessible) and their spell books. It costs money to replace spells in the repertoire (though adding new spells to the repertoire as a result of gaining a level does not cost money). Incidentally, spell selection is also reminiscent of OD&D and B/X; the highest-level arcane spells are sixth level and the highest-level divine spells are fifth level. The are provided in nice d12 and d10 lists.
What about the proficiency system? First, I have to warn you. I hate reading lists of skills and feats. And that is what proficiencies in ACKS are: a mixture of feats and skills. The list is quite long. I count 97, but the real list should be longer, because some have sub-proficiencies which must be selected such as Combat Trickery. Some of them provide a minor mechanical bonus. Some of them open up abilities from classes that are not included in the core. For example, there are Sensing Evil, Lay on Hands, and Berserkergang proficiencies. Another category of proficiencies are 3E-style profession skills (such as the Art and Perform proficiencies) which allow adventurers to earn a mundane wage when not adventuring.
Here's what I like least about the proficiency system: it contains skills like Adventuring and Mapping. Does that mean that a party sans mapping proficiency cannot map? It's not clear, but I think that is the implication. If not, why have the proficiency at all? Thus, a skill tax. Adventuring is given to all PCs, regardless of class, at first level, but the fact that it contains a clear list of capabilities helps foster the attitude that a PC can only attempt to do things that are spelled out on the character sheet. I don't think there is any need to systematize cleaning weapons or setting up camp.
There are some good aspects to the proficiency system. Each proficiency is relatively simple and self-contained. The chance of success is not generally modified by ability scores, so the ability to optimize is limited. There are a number of well-written proficiencies that I think would make great class abilities. Example: Sniping, a ranged backstab. Many of the social proficiencies are designed as a modifier to the reaction roll, which is exactly the right way to do social skills (in fact, I think that general idea might deserve a whole post of its own). This is not the worst skill or feat system in the world, but it is a skill and feat system.
There are now two old school games in print that I think may appeal to new or modern players directly: Lamentations of the Flame Princess and Adventurer Conqueror King System. Labyrinth Lord and Swords & Wizardry are great, but they require the appreciation of a certain aesthetic. ACKS is the first of the retro-clone or simulacrum games to tackle the possibilities inherent in the third LBB (specifically, the rules for generating wilderness domains). In some ways, the endgame and domain rules are the strongest parts of ACKS. I will discuss them in a follow-up post soon.
This entry was posted in Uncategorized and tagged ACKS on February 9, 2012 by Necropraxis.
← Dwimmermount Preview Necromancer →
9 thoughts on "ACKS First Impressions"
George February 9, 2012 at 5:38 pm
Wow – solid write-up. Sounds like a good systems with a lot to mine from it. I have a friend in my group who might really like this. He loves old school vibe but with some modern mechanics.
Beedo February 9, 2012 at 6:05 pm
Brendan – one thing you missed about the Mage Int bonus: the Mage is still limited to casting 1 spell per day at 1st level, but the bonus spells means he has more choice in his spellbook. The bonus is increased versatility.
It's to help even out how most classic magic users all end up looking alike in spell choices.
Mapping proficiency is not required to map, but it does say a player can recall a map from memory; maybe it's a patch for lazy and bad mappers. "We don't feel like mapping, can we just give someone 'mapping proficiency'?"
Brendan February 9, 2012 at 6:32 pm
@Beedo
You're right! I totally misunderstood those rules. I'll need to axe a big chunk of that paragraph.
Re: Mapping proficiency, it's just really hard to see how that would work in play. Player: "I have mapping proficiency, so I follow my map back to the entrance." Referee (after having screwed with players thoroughly with elevator rooms and rotating chambers) "???"
It seems like if you have players who don't like mapping, you should just roll whatever Mapping proficiency is into the Adventuring proficiency.
Did you see the Caving proficiency (page 59)? That seems to have the same problems:
The character has learned to keep a map in his head of where he is when exploring underground caves, cavern complexes, and rivers. On a proficiency throw of 11+, the character with this proficiency will be able to automatically know the route he has taken to get where he is, if he was conscious at the time.
For the sake of posterity, and so Beedo's helpful comment remains coherent, here is the text containing the invalid argument that I cut from the paragraph on spell casting:
The intelligence bonus provides extra spells for each accessible spell level. For example, a mage with a +2 intelligence bonus and the ability to cast up to fourth level spells will have an extra 8 spells per day. These are some interesting house rules and certainly make low-level spell casters more powerful and more versatile. I don't think the suggested "3d6 in order" ability score generation method will survive contact with these rules. Players will want their mage characters to have 18 intelligence because the power differential between a highly intelligent mage and a less intelligent mage is so great. At first level, this is the difference between being able to cast one spell per day and being able to cast four spells per day. At third level, this is the difference between being able to cast 3 spells per day and being able to cast 9 spells per day.
Anathemata February 9, 2012 at 7:49 pm
I sympathize with your dislike of the proficiencies. I wrote a little about it a while back, and further play has confirmed that the system is quite pleasantly workable despite my design/aesthetic quibbles. The question of skills still haunts me, despite the myriad of solutions I've encountered and tried. Although I already play the system, thanks for the review! Thoughtful as always.
Lee Reynoldson February 9, 2012 at 10:06 pm
Damn. Yet another book I now want. I read the page on the ACK implied setting that someone in the blogosphere linked to and that along with the domain game stuff practically sold me. Din't realise it was so close to B/X which is my favourite.
Brendan February 10, 2012 at 4:02 pm
There is one other pro to the proficiency system that I meant to mention, but forgot about before publishing this post. Deferred proficiency selection is explicitly allowed. In other words, you don't have to commit to a proficiency until you think it will be useful in play.
This is something that I have house-ruled in for a long time (I first saw something similar with the LotFP language rules).
Alexander February 12, 2012 at 10:47 pm
Brendan – the intent of the design, there's not supposed to be a skill tax. Adventuring proficiency covers any basic task that a B/X PC could do. I detested that, e.g., in 2e D&D, the introduction of the Riding proficiency meant your character couldn't ride without it anymore.
Mapping proficiency has two aspects (1) mapping complex layouts and (2) mapping from memory. With regard to #1, it's an in-game justification for the common DM practice of giving map guidance to the players, such as sketching the map layouts on a whiteboard or battlemat.
As for #2, mapping from memory, it's use in game is a bit more subtle. Think about it this way: The average D&D player's map is far better made than an actual map created in a dungeon on parchment with quill and ink by torchlight on the move. #2 is partly an in-game justification for that — it suggests that the PC is actually mapping from memory back at the tavern, or polishing up scanty notes. It also helpful if the PCs are captured by orcs and have lost the physical copy of the map.
Brendan February 12, 2012 at 11:57 pm
I agree strongly with the sentiment on 2E proficiencies. I remember there were several like that. Swimming, riding, fire-building, and fishing are all examples.
I admit I'm probably overly critical of any kind of skill system, even a rather simple and hard to optimize one like ACKS proficiencies.
Regarding the mapping proficiency examples you gave specifically, I have a hard time believing that a referee is not going to give map clarifications to a PC who doesn't have the Mapping proficiency, so I don't think that's a good example. Recreating a lost map, or making a copy from memory back at the inn however are excellent examples, and certainly not something I would normally give PCs clarifications for otherwise. So I guess it seems like mapping is really more like a form of eiditic memory? I don't mind PCs creating relatively accurate maps because moving only 120′ in 10 minutes is really, really slow.
I hope my conclusion didn't come off as too negative. I did give a paragraph and several comments worth of pros about the proficiency system also.
I do think that some tables by proficiency type would have helped (those comma separated lists are rather hard to read). Maybe with some numbers attached, so that people could roll for proficiencies like they can roll for spells.


text:
Home News Center Marietta College forges after-school partnership with Ely Chapman
Art Professor named juror for 2023 OAC Biennial Juried Exhibition
Pioneers experiencing success in graduate school
Marietta College forges after-school partnership with Ely Chapman
Marietta College officials are excited to announce the launch of a new initiative aimed at providing entrepreneurship and computer coding skills to area middle school students.
As part of the Ely Chapman Education Foundation afterschool program, Marietta College students will be delivering a year-long curriculum to middle school students to develop their computer coding and entrepreneurial skills. This program was developed with the Department of Math, Computing, and Information Systems and Entrepreneurship Program.
Dr. Jacqueline Khorassani, Director of Entrepreneurship Programs at Marietta College, said she likes the idea of engaging students at a young age.
"We are excited to be a part of this project. It is an opportunity to extend the academic learning and entrepreneurship curriculum beyond our campus," she said. "It will be interesting to watch the students discover new ideas and make entrepreneurial plans based on what they learn over the coming months. Middle school students will also participate in Marietta College's PioPitch program, where they will interact with established and aspiring entrepreneurs. This is a wonderful opportunity for area youth."
Alice Chapman, Founder and Chair of Ely Chapman, said the program is designed to prepare students to develop work and life skills that will prepare them for tomorrow's job market.
"We will try to give the students skills and flexibility that will prepare them for jobs that don't exist today and we can't even dream about," she said. "These classes will try to give the students a way of thinking that will help them adapt to the great changes that they will see in their lifetime."
Students at Ely Chapman have expressed an interest in coding. These students will have the opportunity to learn from students majoring in computing at Marietta College. Bob Van Camp, Associate Professor of Information Systems, said the skill of coding will benefit these students and will help them prepare for future careers.
"Ely Chapman has been a great partner of the College over the past several years," said Robin Stewart, Grants, Corporate and Foundation Gifts Officer. "Our Education and Leadership students have been engaged in internships and other applied learning opportunities at Ely Chapman. Our Physician Assistant students are also gaining valuable experience at Ely Chapman. We are excited to expand this community-based collaboration to provide real-world opportunities for students studying computer science and business and entrepreneurship. We welcome IT businesses in the community to partner with us on this initiative."
Entrepreneurship Program
http://www.marietta.edu/entrepreneurship-department
Information Systems Program
http://www.marietta.edu/program/information-systems
Ely Chapman Education Foundation
http://www.elychapmanedu.org/
Ely Chapman


text:
Mae Simpson Band says 'Goodbye' before communing with the crowd at Hook & Ladder and State Fair this month
WORDS BY Isabelle Wattenberg
Mae Simpson is a band leader, singer, and lyricist—but there's no question that her favorite role is making music on stage, for a live audience.
"It is truly a collective shared moment between audience, music, art, and energy," she says. "Sometimes the best way to understand what someone's trying to say is to be in that moment with them. That's what we're trying to capture."
Simpson is the namesake of the vibrant Mae Simpson Band, which embraces and draws from multiple genres. This open-minded approach to making music is emblematic of the seven-member crew's bond.
"If we know we have something really good then [writing a song] is very quick; it happens in an hour," she says. "And that's just how it works with us. We have that kind of chemistry to really write well in the moment."
Simpson found her voice—which could be compared to the some- times-gritty power-belters Janis Joplin and Brandi Carlile—early on, creating original songs in her childhood. But after moving to Minneapolis in 2012, she began pursuing the art profession- ally. The band released their first EP in 2019, and Simpson credits its steady rise in part to the Twin Cities music scene, where she sees the hard work of emerg- ing bands rewarded, even when they are relatively unknown.
"I think there's a love and appreci- ation in Minneapolis for starting-out artists," she says, noting both First Ave and the Dakota "really accept when you're a young band and help you move along."
The band's momentum is only grow- ing: They'll release a full length album in 2023, and just dropped a new single, Goodbye. Simpson had been kicking around the lyrical hook "Goodbye, good lookin'" for a while. From there the band began building the song, pulling from the sounds of the Jackson 5 to develop its upbeat, unapologetic vibe. The song proposes a positive view of letting things
go. "What inspired it is like shaking things off and saying goodbye to what doesn't serve you," Simpson said of the single. "It's a confidence song about being OK in your skin and moving on."
The band next headlines a party at the Hook and Ladder on August 27, which means another opportunity for them to deliver the intoxicating onstage energy that audiences expect and love from them.
"I honestly don't know what happens… It is feeling-based and I think people appreciate that rawness," Simpson says of the energy of their live performances. "I'll look over at [guitarist] Jorgen mid-rock- out and we'll just be smiling away because we just feel that connection, and I truly think the crowd sees that. And once they see that, they understand that everything that we're doing is real. It's not a show to put on a show. It's true emotion. And they connect with that."
The band is currently preparing for, and planning, a tour to promote their new album next year—they've even got a GoFundMe running to raise money for a touring van. In the meantime, you can catch Mae Simpson and the band at their Hook and Ladder release party, with First Ave on the Schell's stage at the State Fair September 3, and on social media at @ mae_simpson_music.
WHEN YOU GO:
Mae Simpson Band w/Karate Chop, Silence., and The Shackletons
The Hook & Ladder Saturday, August 27 6 PM, $15-$20
Various Dates. Playwright Lauren Yee's exploration of personal and national history follows a rising rock…
In: Editor Pick, Music, Reports


text:
Barrancabermeja är en kommun och stad i Colombia.   Den ligger i departementet Santander, i den norra delen av landet,  km norr om huvudstaden Bogotá. Antalet invånare i kommunen är .
Staden grundades 1536 och centralorten hade 172 103 invånare år 2008.

Källor

Indelningar i Santander, Colombia
Orter i Santander, Colombia


This report shows which links visitors click on your site to leave your site. Exit links are only to sites on another domain. Each time a visitor exits, a click is recorded.
Exits links are also recorded as part of navigation path reports. Each exit link is displayed as a line item on navigation reports.
This report comes in two versions. A summary report that displays exit links across the entire site, and a detailed report that shows exit links from individual pages.


text:
Thrombophilia in East Asian countries: are there any genetic differences in these countries?
Volume 14 Supplement 1
State of the Art 2016: Research and Review from the 9th Congress of the Asian-Pacific Society on Thrombosis and Hemostasis
Toshiyuki Miyata1,
Keiko Maruyama2,
Fumiaki Banno3 &
Reiko Neki4,5
In recent years, genetic analyses of congenital deficiencies of three anticoagulant proteins, antithrombin, protein C (PC) and protein S (PS), in East Asian patients with venous thromboembolism (VTE) have greatly increased. The PS-K196E mutation is often identified in the Japanese population with an allelic frequency of 0.86 %, and a total of approximately 10,000 Japanese are estimated to be homozygotes. The heterozygotes show PS anticoagulant activities ranging from 40 to 110 %, and 16 % lower mean anticoagulant activity than that in wild-type individuals. Specific assay methods to identify carriers of this mutation have recently been developed. The mutation carriers are at risk of thrombosis during pregnancy but do not appear to be at risk for adverse pregnancy outcomes. To promote future research into this mutation and its relation to thrombosis, a thrombosis-prone mouse strain with the PS K196E mutation has been developed. We found the PS-K196E mutation and the heterozygous PS-deficiency in mice caused increased VTE, but did not cause aggravation of ischemic stroke, unlike factor V Leiden mutation. Importantly, the PS-K196E mutation is only identified in Japanese. This suggests that although East Asian populations including Japanese, Chinese, and Koreans are geographically and genetically close, the PS-K196E mutation seems to be Japanese-specific, suggesting that the mutation is a recent occurrence and fixed within the Japanese population. Some recurrent genetic mutations predisposing to VTE have been reported in Chinese and Korean populations. Although the genetic background for VTE is known to differ between populations with Caucasian descent and East Asian populations, some of the recurrent mutations differ even within the East Asian populations.
Venous thromboembolism (VTE) is a worldwide burden associated with death and disability. The R506Q mutation in factor V (FV), also known as the FV Leiden (FVL) mutation, is well known as an established genetic risk factor for VTE in individuals of Caucasian descent [1, 2]. The FVL mutation was identified in 1994; in 1995 we attempted to identify the FVL mutation in the Japanese population, but failed due to its absence in East Asian populations [3]. To identify the genetic variants of VTE in the Japanese population, we performed a nationwide collaborative study of 5 hospitals supported by the Ministry of Health, Labour and Welfare of Japan. In this study, we genotyped the 5 genetic variations and found that a Lys196-to-Glu substitution in the protein S (PS) gene (PS-K196E, rs 121918474, c.586A>G, also known as PS Tokushima, PS-K155E in the mature protein numbering) was a genetic risk factor for VTE with an odds ratio of 4.72 [4, 5]. This finding was published in 2006.
Historically, the PS-K196E mutation was identified simultaneously in 1993 and 1994 by two independent Japanese groups in families with or without VTE [6, 7]. Individuals with the PS-K196E mutation in families without VTE showed PS anticoagulant activity within a normal limit, suggesting the mutation was a neutral polymorphism [6], whereas individuals with the mutation in another family with VTE showed low PS anticoagulant activity, suggesting PS-K196E was causative for VTE [7, 8]. Therefore, whether the mutation would be a risk for VTE was debatable. A subsequent our study, however, revealed that both observations were correct, because the heterozygous carriers of this mutation in a general population showed anticoagulant activities ranging from 40 up to 110 %, that were substantially overlapped with those of wild-type individuals [9]. In this short review, we will summarize the history of the PS-K196E mutation and discuss the similarities or differences of the genetic background for VTE among East Asians.
Prevalence and unique geographical profile of PS-K196E mutation
Three case-control studies of VTE independently indicated that the PS-K196E mutation is a genetic risk factor for VTE in the Japanese population (odds ratio = 3.74–8.56) (Table 1) [4, 10, 11]. In the Japanese population, a total of 81 heterozygotes have so far been identified among 4686 individuals enrolled in four studies [4–6, 10, 11] and two public genome databases ([12], http://www.genome.med.kyoto-u.ac.jp/SnpDB/index.html), yielding an allele frequency of 0.86 % for the PS-K196E mutation, and indicating that approximately 1 of 58 Japanese is a heterozygous carrier. We thus estimate that approximately 1 of every 13,000 Japanese individuals is homozygous for the mutant allele. The Japanese population was approximately126 million on 1 January 2015, meaning that as many as 9440 individuals are homozygotes for the PS-K196E mutation. Thus, a substantial number of Japanese carry the mutant PS 196E allele, as a heterozygote or homozygote, and are likely at risk of developing VTE. So far, no homozygotes have been identified in the general population, but three homozygotes have been found among 258 VTE patients, yielding an incidence of 1.2 % among patients with VTE [10, 13].
Table 1 Influence of genetic variants on VTE in protein S, protein C, and antithrombin genes in East Asian population
The risk of developing VTE conferred by PS-K196E thus appears to be fairly mild (odds ratio: 3.74–8.56). Accordingly, some VTE patients have been found to bear PS-K196E along with other deleterious genetic mutations, such as PC-K193del, PC-R221W, and PC-V339M, indicating that carriage of the PS-K196E mutation concomitant with other predisposing mutations for thrombosis facilitates the onset of VTE [13].
Although East Asians, including Japanese, Chinese, and Koreans, are geographically and genetically close, the PS-K196E mutation has so far been identified only in Japanese and not in Chinese and Koreans, even in the VTE patients [14–17]. Thus, PS-K196E mutation seems to be Japanese-specific, suggesting that the mutation is a recent occurrence and fixed within the Japanese population.
Anticoagulant activity of heterozygous carriers of PS-K196E mutation
We performed a phenotype-genotype analysis in individuals with or without PS-K196E mutation in the Japanese general population (n = 1862), and found that heterozygotes (n = 34) showed anticoagulant activities ranging from 40 to 110 %, and the anticoagulant activities between heterozygotes and wild-types were substantially overlapped [9]. Thus, the anticoagulant activity assay widely used for the identification of PS deficiency is not a good tool to identify the PS-K196E carriers. The mean PS anticoagulant activity in heterozygotes, however, was 16 % lower than that in wild-type individuals. Acquired PS deficiency is associated with nephrotic syndrome or pregnancy. These conditions may further promote the PS-activity reduction in mutation carriers, thereby enhancing the risk for VTE.
DVT and adverse pregnancy outcome in pregnant women with PS-K196E mutation
The PS-K196E mutation appears to be a genetic risk factor for deep vein thrombosis (DVT) during pregnancy [18]. Among 18 patients with DVT during pregnancy and the postpartum period, we identified 4 DVT patients with PS mutation and 1 DVT patient with PC mutation [18]. Among the 4 DVT patients with PS mutation, 2 were heterozygous for the PS-K196E mutation with DVT onset of 27 and 10 weeks, respectively. None carried mutations in the antithrombin gene. All patients with the genetic mutation showed DVT at the first or second trimester and none showed DVT at the third trimester or postpartum period. It is well known that the PS anticoagulant activity is decreased in pregnancy. Since the genetic mutation accelerates DVT onset, DVT onset at the early stage of pregnancy in patients with the PS-K196E mutation would be reasonable.
Adequate maternal-fetal circulation is important for a successful pregnancy outcome, and disturbance of circulation may result in serious adverse pregnancy outcomes, such as severe preeclampsia, placental abruption, intrauterine fetal death (IUFD), or severe fetal growth restriction (FGR). The causes of these adverse pregnancy outcomes are not known, but they may be associated with abnormal placental vasculature and disturbances of hemostasis.
In a previous report, we tried to address whether adverse pregnancy outcomes in Japanese parturients are associated with the PS-K106E mutation or rare genetic mutations in three anticoagulant genes: PS, PC, and antithrombin [19]. We enrolled 330 Japanese patients with adverse pregnancy outcomes and divided them into 233 patients with two or more miscarriages and 114 patients with FGR and/or IUFD; 17 patients belonged to both groups. In this cohort, the PS-K196E mutation was identified in 4 out of 233 patients with two or more miscarriages and 2 out of 114 patients with FGR and/or IUFD. The frequencies of the PS-K196E mutation in these patient groups were not different from that in the Japanese general population. Therefore, the PS-K196E mutation does not confer a significantly increased risk of these adverse pregnancy outcomes. Our results were compatible to those of a recent large prospective cohort study in Canada in which carriage of FVL or the prothrombin G20210A mutation did not increase the risk for the adverse pregnancy outcomes of pregnancy loss, small for gestational age, preeclampsia, or placental abruption [20].
In our study, rare nonsynonymous mutations in the three anticoagulant genes were found in only 3.3 % (11 out of 330) of patients with adverse pregnancy outcomes, indicating that carriers with rare mutations were not dominant in patients [19]. Therefore, although the small fraction of patients with adverse pregnancy outcomes may be explained by the rare variations in the three anticoagulant genes, these rare mutations are not likely a major cause of the development of adverse pregnancy outcomes.
Screening methods for PS-K196E mutation carriers
As described above, the anticoagulant PS activity is not a reliable measure for the identification of PS-K196E mutation carriers, and thus until recently the only accurate detection assay was DNA analyses such as direct sequence analysis, restriction fragment length polymorphism analysis, or the TaqMan genotype discrimination method. More recently, however, two plasma assay methods were developed to distinguish the carriers from the wild-type individuals.
We developed monoclonal antibodies specific to the PS K196E mutant using GANP transgenic mice that show an increased frequency of somatic mutations in the Ig-variable region and are suitable for high-affinity antibody production [21]. We constructed a sandwich enzyme-liked immunosorbent assay (ELISA) using one of the monoclonal antibodies for detecting plasma samples of individuals with the PS K196E mutation [21]. This assay is a simple, efficient, and accurate tool for the detection of PS-K196E carriers. The ELISA assay can detect the PS K196E mutant in plasma and can be identified in carriers even though they are under warfarin treatment or during pregnancy.
Another assay has been developed using the specific activity of PS for the discrimination of heterozygotes from the wild-types [22]. Since individuals with PS type II deficiency who are carriers of the PS-K196E mutation show the reduced PS activity with normal antigen limits, the specific activity obtained as the ratio of the activity level divided by the antigen level would be reduced to around 0.5. Actually, the mean PS specific activity of the PS-K196E heterozygote carriers was 0.64 [22]. This assay can distinguish individuals with the PS type II deficiency who are carriers of the PS-K196E mutation from wild-type individuals. However, individuals with low specific activity do not always have the PS K196E mutation and may have other missense mutations.
Mice bearing PS-K196E mutation
Guidelines for establishing pathogenic causality for rare genetic variants have recently been published [23]. They suggest that the strongest evidence for causality comes from disruption of the candidate gene in a model organism which recapitulates the pathology in humans. To evaluate the thrombogenicity of the PS-K196E mutation, we generated PS-K196E knock-in mice and analyzed their phenotypes in comparison with heterozygous PS-deficient mice and factor V-R504Q knock-in mice (FVL mice) [24]. Plasma from PS-K196E homozygous mice had 67 % of normal APC cofactor activity, similar to a purified recombinant murine PS-K196E mutant that had 49 to 60 % of normal PS activity. Mouse C4BP does not contain the PS-binding ß-chain, which is a pseudogene in mice, so interpretation of the APC cofactor activity is uncomplicated by C4BP considerations.
The susceptibility of PS-K196E mice to VTE was assessed in multiple models, including (i) an electrolytic inferior vena cava model of venous thrombosis that produces a non-occlusive and consistent thrombus in the presence of constant blood flow, (ii) a tissue factor-initiated pulmonary thromboembolism model, and (iii) a polyphosphate-initiated pulmonary thromboembolism model [24]. All thrombotic parameters in these thrombosis models, including mortality, showed that the PS-K196E mutation in mice caused increased VTE, very similar to the heterozygotes for PS deficiency and to the murine FVL mutation. Heterozygotes for the PS-K196E mutation gave a milder thrombotic phenotype than homozygotes. These results demonstrate a causal link between the PS-K196E mutation and thrombophilia, strongly supporting the notion that the PS-K196E mutation is a human genetic risk factor for VTE. PS K196E mice would be valuable for disease-related studies in which FVL mice have been examined.
Currently, the extent to which the PS-K196E mutation or PS deficiency are risk factors for arterial occlusive diseases is not clear. To explore the arterial occlusive risk of these PS genetic variations, we used a cerebral focal ischemia-reperfusion model. We found no exacerbation of ischemic stroke in PS-K196E mice and heterozygous PS-deficient mice [24]. We previously observed that FVL mice showed increased infarct volumes compared with wild-type mice [25]. Our studies suggest that PS-K196E mutation in mice does not cause aggravation of ischemic stroke, unlike factor V Leiden mutation.
Thrombophilic mutations in Chinese and Korean populations
Genetic analyses in patients with VTE and in the general populations have been reported from China and Korea as well. The PC Arg189Trp mutation (PC-R189W, c.565C>T, PC-R147W in the mature protein numbering) and the PC Lys193del mutation (PC-K193del, c.574-576del, PC-K151del in the mature protein numbering) were reported to be risk factors for VTE in the Chinese population, with odds ratios of 5.10–7.30 and 2.93, respectively (Table 1) [26–28]. Both R189 and K193 residues are located on a 21-amino-acid peptide, with 8 basic Lys and Arg amino acids on it, in the C-terminal part of the PC light chain. The PC-R189W and K193del mutations are present in 0.9 and 2.4 % of the Chinese population, respectively [26, 28]. The former mutation was not identified in 767 Japanese, but the later was identified in 10 out of 767 Japanese including one homozygote [http://www.genome.med.kyoto-u.ac.jp/SnpDB/index.html], and both mutations were identified in Japanese and Korean patients with VTE. Both heterozygotes are associated with reduced anticoagulant activity and a relatively normal PC antigen level, indicating type II deficiency. The recombinant PC-R189W mutant shows normal amidolytic and proteolytic activities in the absence of cofactors, but exhibits about 3 times lower affinity for binding to EPCR [29]. The recombinant PC-K193del mutant has approximately 2–3 fold impaired anticoagulant activity in the presence of PS [29]. Individuals with the PC-K193del mutation show normal amidolytic activity of PC but reduced anticoagulant activity [13, 30].
In the genetic analysis in the Korean population, the PC Arg211Trp (PC-R211W, PC-R169W in the mature protein numbering) and Met406Ile (PC-M406I, PC-M364I in the mature protein numbering) mutations, both of which cause type I PC deficiency, were identified in 2.8 and 1.8 % of the VTE patients, and 0.2 and 0 % of the Korean population (Table 1), respectively [16]. Both PC mutations have been identified in Japanese VTE patients [30], but not in the Japanese Human Genetic Variation Database [http://www.genome.med.kyoto-u.ac.jp/SnpDB/index.html]. In the antithrombin gene, the Arg79Cys and Ser158Pro mutations (AT-R79C and AT-S158P, AT-R47C and AT-S116P in the mature protein numbering, respectively) have been identified in 0.4 and 0.2 % of Korean VTE patients, respectively (Table 1). Both mutations have previously been identified in Japanese VTE patients with heparin-binding defects. Since both were also present in the Korean general population, they would confer weak risk for VTE (Table 1), if any. We previously demonstrated that the antithrombin deficiency with the heparin-binding defects conferred a lower VTE risk than type I deficiency [31], and this finding was compatible with the Korean VTE study.
We identified a PS-K196E mutation as a mild genetic risk factor for VTE. The mutation is specific to the Japanese population and not present in Chinese and Koreans. We generated a mouse line carrying the PS K196E mutation. The thrombosis phenotypes observed in the PS K196E mice indicated a strong link between the PS-K196E mutation and thrombosis. Compared with the frequencies of genetic mutations among East Asian populations, many genetic mutations predisposing to VTE, except for the PS K196E mutation, are commonly distributed, but their frequencies differ among East Asian countries.
Dahlback B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci U S A. 1993;90(3):1004–8.
Bertina RM, Koeleman BP, Koster T, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature. 1994;369(6475):64–7. doi:10.1038/369064a0.
Fujimura H, Kambayash J, Monden M, et al. Coagulation factor V Leiden mutation may have a racial background. Thromb Haemost. 1995;74(5):1381–2.
Kimura R, Honda S, Kawasaki T, et al. Protein S-K196E mutation as a genetic risk factor for deep vein thrombosis in Japanese patients. Blood. 2006;107(4):1737–8. doi:10.1182/blood-2005-09-3892.
Miyata T, Kimura R, Kokubo Y, et al. Genetic risk factors for deep vein thrombosis among Japanese: importance of protein S K196E mutation. Int J Hematol. 2006;83(3):217–23. doi:10.1532/IJH97.A20514.
Yamazaki T, Sugiura I, Matsushita T, et al. A phenotypically neutral dimorphism of protein S: the substitution of Lys155 by Glu in the second EGF domain predicted by an A to G base exchange in the gene. Thromb Res. 1993;70(5):395–403.
Hayashi T, Nishioka J, Shigekiyo T, et al. Protein S Tokushima: abnormal molecule with a substitution of Glu for Lys-155 in the second epidermal growth factor-like domain of protein S. Blood. 1994;83(3):683–90.
Shigekiyo T, Uno Y, Kawauchi S, et al. Protein S Tokushima: an abnormal protein S found in a Japanese family with thrombosis. Thromb Haemost. 1993;70(2):244–6.
Kimura R, Sakata T, Kokubo Y, et al. Plasma protein S activity correlates with protein S genotype but is not sensitive to identify K196E mutant carriers. J Thromb Haemost. 2006;4(9):2010–3. doi:10.1111/j.1538-7836.2006.02071.x.
Kinoshita S, Iida H, Inoue S, et al. Protein S and protein C gene mutations in Japanese deep vein thrombosis patients. Clin Biochem. 2005;38(10):908–15. doi:10.1016/j.clinbiochem.2005.05.006.
Ikejiri M, Wada H, Sakamoto Y, et al. The association of protein S Tokushima-K196E with a risk of deep vein thrombosis. Int J Hematol. 2010;92(2):302–5. doi:10.1007/s12185-010-0671-0.
Consortium TGP. A map of human genome variation from population-scale sequencing. Nature. 2010;467(7319):1061–73. doi:10.1038/nature09534.
Miyata T, Sato Y, Ishikawa J, et al. Prevalence of genetic mutations in protein S, protein C and antithrombin genes in Japanese patients with deep vein thrombosis. Thromb Res. 2009;124(1):14–8. doi:10.1016/j.thromres.2008.08.020.
Liu W, Yin T, Okuda H, et al. Protein S K196E mutation, a genetic risk factor for venous thromboembolism, is limited to Japanese. Thromb Res. 2013;132(2):314–5. doi:10.1016/j.thromres.2013.05.008.
Tang L, Jian XR, Hamasaki N, et al. Molecular basis of protein S deficiency in China. Am J Hematol. 2013;88(10):899–905. doi:10.1002/ajh.23525.
Kim HJ, Seo JY, Lee KO, et al. Distinct frequencies and mutation spectrums of genetic thrombophilia in Korea in comparison with other Asian countries both in patients with thromboembolism and in the general population. Haematologica. 2014;99(3):561–9. doi:10.3324/haematol.2013.092023.
Yin T, Miyata T. Dysfunction of protein C anticoagulant system, main genetic risk factor for venous thromboembolism in northeast Asians. J Thromb Thrombolysis. 2014;37(1):56–65. doi:10.1007/s11239-013-1005-x.
Neki R, Fujita T, Kokame K, et al. Genetic analysis of patients with deep vein thrombosis during pregnancy and postpartum. Int J Hematol. 2011;94(2):150–5. doi:10.1007/s12185-011-0902-z.
Neki R, Miyata T, Fujita T, et al. Nonsynonymous mutations in three anticoagulant genes in Japanese patients with adverse pregnancy outcomes. Thromb Res. 2014;133(5):914–8. doi:10.1016/j.thromres.2014.02.012.
Rodger MA, Langlois NJ. Is thrombophilia associated with placenta-mediated pregnancy complications? A prospective cohort study: reply. J Thromb Haemost. 2014;12(8):1378–9. doi:10.1111/jth.12632.
Maruyama K, Akiyama M, Kokame K, et al. ELISA-based detection system for protein S K196E mutation, a genetic risk factor for venous thromboembolism. PLoS One. 2015;10(7):e0133196. doi:10.1371/journal.pone.0133196.
Tsuda T, Jin X, Tsuda H, et al. New quantitative total protein S-assay system for diagnosing protein S type II deficiency: clinical application of the screening system for protein S type II deficiency. Blood Coagul Fibrinolysis. 2012;23(1):56–63. doi:10.1097/MBC.0b013e32834ddefd.
MacArthur DG, Manolio TA, Dimmock DP, et al. Guidelines for investigating causality of sequence variants in human disease. Nature. 2014;508(7497):469–76. doi:10.1038/nature13127.
Banno F, Kita T, Fernandez JA, et al. Exacerbated venous thromboembolism in mice carrying a protein S K196E mutation. Blood. 2015;126(19):2247–53. doi:10.1182/blood-2015-06-653162.
Kita T, Banno F, Yanamoto H, et al. Large infarct and high mortality by cerebral ischemia in mice carrying the factor V Leiden mutation. J Thromb Haemost. 2012;10(7):1453–5. doi:10.1111/j.1538-7836.2012.04776.x.
Tsay W, Shen MC. R147W mutation of PROC gene is common in venous thrombotic patients in Taiwanese Chinese. Am J Hematol. 2004;76(1):8–13. doi:10.1002/ajh.20043.
Tang L, Guo T, Yang R, et al. Genetic background analysis of protein C deficiency demonstrates a recurrent mutation associated with venous thrombosis in Chinese population. PLoS One. 2012;7(4):e35773. doi:10.1371/journal.pone.0035773.
Tang L, Lu X, Yu JM, et al. PROC c.574_576del polymorphism: a common genetic risk factor for venous thrombosis in the Chinese population. J Thromb Haemost. 2012;10(10):2019–26. doi:10.1111/j.1538-7836.2012.04862.x.
Ding Q, Yang L, Hassanian SM, et al. Expression and functional characterisation of natural R147W and K150del variants of protein C in the Chinese population. Thromb Haemost. 2013;109(4):614–24. doi:10.1160/TH12-10-0760.
Miyata T, Sakata T, Yasumuro Y, et al. Genetic analysis of protein C deficiency in nineteen Japanese families: five recurrent defects can explain half of the deficiencies. Thromb Res. 1998;92(4):181–7.
Mitsuguro M, Sakata T, Okamoto A, et al. Usefulness of antithrombin deficiency phenotypes for risk assessment of venous thromboembolism: type I deficiency as a strong risk factor for venous thromboembolism. Int J Hematol. 2010;92(3):468–73. doi:10.1007/s12185-010-0687-5.
This work was supported in part by grants-in-aid from the Ministry of Health, Labour and Welfare of Japan; the Japan Society for the Promotion of Science; the Takeda Scientific Foundation; and the Intramural Research Fund.
Publication fees for this article have been funded by APSTH 2016.
This article has been published as part of Thrombosis Journal Volume 14 Supplement 1, 2016. The full contents of the supplement are available at https://thrombosisjournal.biomedcentral.com/articles/supplements/volume-14-supplement-1.
TM drafted the manuscript and KM, FB, and RN critically revised the manuscript. All the authors approved the final manuscript.
Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, 5658565, Japan
Toshiyuki Miyata
Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center, Suita, 5658565, Japan
Keiko Maruyama
Department of Food and Nutrition, Koriyama Women's University, Koriyama, 9638503, Japan
Fumiaki Banno
Division of Counseling for Medical Genetics, National Cerebral and Cardiovascular Center, Suita, 5658565, Japan
Reiko Neki
Department of Perinatology and Gynecology, National Cerebral and Cardiovascular Center, Suita, 5658565, Japan
Correspondence to Toshiyuki Miyata.
Miyata, T., Maruyama, K., Banno, F. et al. Thrombophilia in East Asian countries: are there any genetic differences in these countries?. Thrombosis J 14 (Suppl 1), 25 (2016). https://doi.org/10.1186/s12959-016-0109-x
DOI: https://doi.org/10.1186/s12959-016-0109-x
Genetic mutation
Racial difference
Thromboembolism
Venous thrombosis


text:
Scars (permanent): People who get acne cysts and nodules often see scars when the acne clears. You can prevent these scars. Be sure to see a dermatologist for treatment if you get acne early — between 8 and 12 years old. If someone in your family had acne cysts and nodules, you also should see a dermatologist if you get acne. Treating acne before cysts and nodules appear can prevent scars.
All acne is not, actually, created equal. This makes perfect sense, seeing as there are so many factors — i.e. hygiene, hormones, and genetics — that can both lead to and exacerbate your breakouts. But knowledge is power, and just knowing that there are different types, and that each kind requires its own plan of attack, puts you ahead of the clear-skin curve. Once you figure out what you're working with, it gets far easier to treat. Here, your ultimate guide to identifying, and then taking down, every type of acne out there, according to dermatologists. Find out how to identify and deal with the different kinds of acne, including blackheads, whiteheads, blind pimples, and cystic zits.
Bowling was right not to worry. Baby acne — or newborn acne, as it's called to distinguish it from infantile acne, which occurs in older babies — is usually harmless and quite common. "It occurs in about 20 percent of newborns, typically around the time when they're 3 – to 4-weeks-old," says Mary Yurko, M.D., PhD, a pediatric dermatologist in Grand Rapids, Michigan.
Salicylic acid and azelaic acid. Azelaic acid is a naturally occurring acid found in whole-grain cereals and animal products. It has antibacterial properties. A 20 percent azelaic acid cream seems to be as effective as many conventional acne treatments when used twice a day for at least four weeks. It's even more effective when used in combination with erythromycin. Prescription azelaic acid (Azelex, Finacea) is an option during pregnancy and while breast-feeding. Side effects include skin discoloration and minor skin irritation.
Acne mechanica is caused by heat, friction, and pressure against the skin, often the result of wearing sports gear such as a helmet or baseball cap. It is sometimes called "sports-induced acne" because it occurs frequently in athletes. Preventive measures include wearing an absorbent material under sports equipment and showering immediately after activity.
Side effects include increased skin photosensitivity, dryness, redness and occasional peeling.[80] Sunscreen use is often advised during treatment, to prevent sunburn. Lower concentrations of benzoyl peroxide are just as effective as higher concentrations in treating acne but are associated with fewer side effects.[79][81] Unlike antibiotics, benzoyl peroxide does not appear to generate bacterial antibiotic resistance.[80]
The recognition and characterization of acne progressed in 1776 when Josef Plenck (an Austrian physician) published a book that proposed the novel concept of classifying skin diseases by their elementary (initial) lesions.[163] In 1808 the English dermatologist Robert Willan refined Plenck's work by providing the first detailed descriptions of several skin disorders using a morphologic terminology that remains in use today.[163] Thomas Bateman continued and expanded on Robert Willan's work as his student and provided the first descriptions and illustrations of acne accepted as accurate by modern dermatologists.[163] Erasmus Wilson, in 1842, was the first to make the distinction between acne vulgaris and rosacea.[164] The first professional medical monograph dedicated entirely to acne was written by Lucius Duncan Bulkley and published in New York in 1885.[165][166]
Pimples are raised red spots with a white center that develop when blocked hair follicles become inflamed or infected with bacteria. Blockages and inflammation that develop deep inside hair follicles produce cystlike lumps beneath the surface of your skin. Other pores in your skin, which are the openings of the sweat glands, aren't usually involved in acne.
Contact us at webmaster@say-no-to-acne.com | Sitemap xml | Sitemap txt | Sitemap


Sleepovers can be a bit scary for the littlest ones. But the brontosaurus on this suitcase can help. He is a cute little friend who chases away all the scaries with his loud 'GRRR'. The light blue suitcase is big enough to pack a set of clothes and a toothbrush.


LA duo No Age are to play Korova on Friday October 4 as part of their extensive UK tour.
The Subpop alt-rockers release fourth album An Object, the follow up to superlative Everything in Between on August 19 while latest single C'mon Stimmung was named our single of the week last month.
The record, which includes highlights, I Won't Be Your Generator, C'mon, Stimmung, An Impression and Lock Box, was recorded by F. Bermudez and No Age at Gaucho's Electronics in Los Angeles.
As previously reported on Getintothis, Korova – a bar unaffiliated with the previous two incarnations of the popular Liverpool club – is to reopen later this year at 52-54 Wood Street. Full story here.
Getintothis reviews No Age and Times New Viking at O2 Academy.
No Age's Everything In Between named in Getintothis' albums of the week.


text:
Canada's Henderson alone in first place at LPGA's Marathon Classic
PMN Golf
SYLVANIA, Ohio — Canada's Brooke Henderson is heading into the final round of the LPGA Tour's Marathon Classic with sole possession of the lead.
The 20-year-old from Smiths Falls, Ont., shot a 2-under 69 Saturday for an 11 under total through 54 holes and a one-stroke advantage over Americans Angela Stanford and Brittany Lincicome.
Henderson, who entered the third round tied for the lead with Sweden's Caroline Hedwall at 9 under, fired five birdies to help even out an up-and-down round that also featured three bogeys.
Henderson, who birdied the 17th to take sole possession of the lead, admitted she was disappointed with her play on Saturday.
"I made some birdies but I made some bogeys. I didn't hit it how I normally hit it, so I kind of grinded it out as best I could, and that's good," she said. "That's a good sign when you can still shoot under par and not hit it very well. Just going into tomorrow trying to get back to the way I normally strike it, and hopefully make a lot of birdies."
Stanford tied the best score of the day at 65 while Lincicome shot 67. Hedwall dipped into a tie for 21st place with a 74.
Seeking her first win since 2012, Stanford has shot back-to-back 65s after an opening-round 73. She credited a hot putter for her surge.
"I think that's kind of what's kept me in it," Stanford said. "I'm seeing the lines pretty well. I didn't have the speed the first day. I didn't have it at all. I kind of figured it out the last two days."
Lincicome had a 4-under 67, including birdies on two of the final three holes. In 10 previous Marathon Classics, her best finish was a tie for seventh in 2008.
"This golf course is sneaky tight," said the big-hitting Lincicome, who is also seeking her second victory of the season. "I don't get to hit very many drivers, but even the 3-woods and the hybrids off the tee, you have to keep it in play, and there are a few holes out there that I just pray I get through with a par, and we try to birdie the others."
Brittany Marchand (70) of Orangeville, Ont., was six shots back of Henderson in a tie for 30th place. Hamilton's Alena Sharp (71) was 11 shots off the pace.
Henderson has six LPGA Tour victories, including the Lotte Championship earlier this season. She is two victories away from tying Sandra Post's record eight by a Canadian woman.
This is the fifth time in Henderson's career she has held the 54-hole lead. She went on to win on three of the four prior occasions.
"It's going to take a really good score," Henderson said of Sunday's challenge. "Lot of people shot minus-6, minus-5 today. So I would imagine something close to that tomorrow would do the job."
A win, worth US$240,000, would vault Henderson into second on the LPGA money list this year.
Henderson is looking to become just the third player to win multiple events on the LPGA Tour this year.


text:
Q: extract first item from series of lists and use as index So I start with this series containing lists, and the first item in the list is to be extracted and used as the index, and the rest of the list are strings to be joined.
coms = pd.Series({
    0: ['1593610', 'comment1', 'comment2'],
    1: ['1593613', 'comment4', 'comment5', 'comment6', 'comment7', 'comment9', 'comment10'],
    2: ['15936111'],
    3: ['15936112'],
    4: ['15936114'],
    5: ['15936115'],
    6: ['15936116'],
    7: ['15936117'],
    8: ['15936118', 'comment19', 'comment21', 'comment22'],
    9: ['15936123']})

I managed to solve it with
coms.index = coms.str.get(0)
coms = coms.str.slice(start=1).str.join(', ')

Output
ID
1593610                                    comment1, comment2
1593613     comment4, comment5, comment6, comment7, commen...
15936111
15936112
15936114
15936115
15936116
15936117
15936118                      comment19, comment21, comment22
15936123
Name: ID, dtype: object

But before that I tried something that I don't get why it did not work.
# works fine, returns the expected series with default index
coms = pd.Series(coms.str.slice(start=1).str.join(', '))

# works fine, returns empty series with desired index
coms = pd.Series('', index=coms.str.get(0))

# does not work!! returns a series with the desired index but all `np.nan` values
coms = pd.Series(coms.str.slice(start=1).str.join(', '), index=coms.str.get(0))

# print(coms)
ID
1593610     NaN
1593613     NaN
15936111    NaN
15936112    NaN
15936114    NaN
15936115    NaN
15936116    NaN
15936117    NaN
15936118    NaN
15936123    NaN
Name: ID, dtype: object

Any idea why?

A: You should add values, without adding the values coms.str.slice(start=1).str.join(', ') still series with index from 0 to n, dose not match with new index assigned
pd.Series(coms.str.slice(start=1).str.join(', ').values, index=coms.str.get(0))


text:
Coronavirus outbreak in China claims 17th victim
David McCabe updated Jun 26, 2018
The Supreme Court decision Silicon Valley is reading
Supreme Court Justice Clarence Thomas. Photo: Alex Wong/Getty Images
The ripples of a Monday Supreme Court ruling in favor of American Express could be felt on the West Coast, with some arguing it would make it harder for antitrust enforcers to take on big online platforms like Google, Facebook and Amazon.
Why that matters: Many of tech's most profitable firms have created two-sided markets: Google and Facebook serve consumers on one side and marketers on another. Uber links up riders and drivers. Amazon serves customers and also the merchants who use its platform. All these situations make defining a monopoly more difficult.
Justice Clarence Thomas agreed with a lower court that when making an antitrust call on a company that does transactions across a two-sided marketplace, you have to consider whether the whole enterprise is anticompetitive — not just one side of the market. (The case in question concerned American Express' policy discouraging merchants who tried to push customers to use cards with lower merchant fees.)
Yes, but: Thomas split up companies that create two sided markets into two categories, and only applied his analysis to one of them.
He said that his analysis could be applied to "two-sided transaction platforms" that "facilitate a single, simultaneous transaction between participants," including Amex.
But he argued that the courts could consider only one side of a two-sided marketplace "when the impacts of indirect network effects and relative pricing in that market are minor," as is true with a newspaper where readers and advertisers aren't selling anything directly to one another.
Category #2 could be seen as covering Facebook and Google, said Lina Khan, the Director of Legal Policy at the Open Markets Institute, as opposed to companies like Amazon that set up more direct transactions between buyer and seller. "I think instances where you have targeted advertisements funding another business that you're providing to a user, I think those types of cases would risk falling into the type of category that Thomas tries to create," she said of his reference to newspapers.
Khan, who argues for more vigorous antitrust enforcement, said she worried Thomas' ruling creates a murky standard where companies will argue they fall into Category #1 to avoid antitrust enforcers.
The other side: "This case, for the tech industry, simply represents a clarification of the dynamics of two-sided business models captured in a legal decision," said Marianela López-Galdos, Director of Competition and Regulatory Policy at CCIA, a tech lobbying group that filed a legal brief supporting some of Amex's case. "I don't think it gives a free pass to the tech industry."
What's next: Cowen Washington Research Group analyst Paul Gallant wrote in a Monday evening note that he'll be watching for reaction from DOJ antitrust chief Makan Delrahim and Federal Trade Commission chairman Joe Simons — who is going to hold public hearings on the competitive impact of tech platforms — to see how the ruling could affect their approach to tech cases.
Get more stories like this by signing up for our daily tech newsletter, Login.


text:
A felületszerelési technológia (surface-mount technology, SMT) olyan technológia, melynek során láb nélküli alkatrészeket (BGA, SMD ellenállás, SMD kondenzátor), illetve rövid lábú IC-ket, csatlakozókat közvetlenül a nyomtatott huzalozású lemez felületére forrasztanak. Az eljárás során nincs szükség furatok elhelyezésére a hordozó felületén. Az 1960-as években találták fel, de csak az 1980-as évek vége óta vált igazán elterjedtté az iparban. Jelentősége, hogy az automatizált gépsorok sokkal gyorsabban tudják elhelyezni ezeket az alkatrészeket a hordozón, mint a lábakkal rendelkező, furatszerelt alkatrészeket, ezzel növelve a gyártás hatékonyságát.

Lényege
Lényege, hogy a furatszerelési technológiával szemben kisebb alkatrészeket alkalmaz, illetve a NYÁK mindkét oldala használható.
Előnyök:
Kisebb alkatrészek
Nagy alkatrészsűrűség
Nagy lábsűrűség (IC esetén)

Hátrányok:
Lábak hiányában kezelésük szakértelmet és pontosságot igényel
Magasabb feszültséget és áramerősséget nem bírnak
Esztétikai szempontból alulmaradnak a furatszerelt alkatrészekkel szemben

Alkatrészek (SMD)
Ez a technológia láb nélküli alkatrészeket használ (Integrált áramkör|IC] esetén rövid lábút), melyek radikálisan újra lettek tervezve. Különlegesség, hogy hagyományos, furatszerelt alkatrészekkel használható. Hagyományos felületszerelt alkatrészek: ellenállás, tekercs, dióda, relé, csatlakozók, kapcsolók, mikropanelek.

Többféle beültetőgép létezik, ilyen például az AX, a Siemens, illetve a Fuji NXT.

Az SMT sorfelépítése:

Mindenképp szükségünk van valamilyen paneladagoló berendezésre. (Loader, buffer) Az SMT-n található gépeket szállítószalag ún. konveyor köti össze. Tehát az adagoló után mindenképp kell egy konveyor. Ezt követi egy pasztázásra alkalmas berendezés (MPM, DEK). Én itt a DEK-et fejteném ki bővebben. A DEK pasztázásra illetve ragasztásra tervezett gép. A felületszerelt alkatrészeket vagy foraszpaszta vagy hőre száradó, keményedő ragasztó kapcsolja a pad-hez (forrasztási, kapcsolódási pont). A forraszpasztát/ragasztót stencilen keresztül viszi fel a panelre. A stencil egy olyan alumínium lap, ami a panel pad-jeinek helyén ki van vágva (ezt nevezzük appertúrának). Ezt egy konveyor követi, majd egy pasztamagasság mérő berendezés pl. Koh-Young. A Koh-young fény-árnyék elven számolja ki a magasságot. Megvilágítja a pad-et és az árnyékból számol. Ezt szintén konveyor követi, majd ha pl. Fuji-t használunk akkor egy ún. shuttle (osztó konveyor). Erre azért van szükség mivel a Fuji két lane-n képes gyártani a shuttle hivatott a két lane között elosztani a panelt. A Fuji különböző méretű beültetőfejeket használ. Pl. V12, H8, H4, H1. A számok azt jelölik, hogy a fej hány nozzle-t képes  egyszerre felvenni. A fej nozzle-k segítségével veszi fel az alkatrészt. Váákumot használ. Az alkatrészeket feederre fűzik, elhelyezik a megfelelő modul megfelelő slotjába (program szerint dolgozik, az alkatrészeknek előre megírt helyük van, ami tartalmazza a léptetést, a cikkszámot, a feeder nagyságát [8,12,16,24,32,44,56,72 stb.] amely az alkatrészt hordozó reel szélességével egyenlő.) A fej értemegy az alkatrészért, megvizsgálja (part camera, sidelight camera, illetve a V12-es fej beépített IPS kamerával rendelkezik tehát azt használja) és ha az alkatrész a programnak megfelelő paraméterekkel rendelkezik (magasság, szélesség, hosszúság, jó a fényerő, tolerancia,) beülteti a programnak megfelelő CRD-re. (CRD=pad egyedi száma.) Ha az alkatrész nem megfelelő eldobja azt a gyűjtődobozába (reject box) illetve hibával megáll. A Fuji képes furatszerelt alkatrészek beültetésére is, nem csak a felületszereltre, illetve van hozzá ragasztófej, ami a DEK helyett képes ragasztót felvinni. Ezt szintén egy shuttle követi, mivel a gyártósor többi része egy lane-en képes gyártani. Majd egy konveyor következik, amire a shuttle kiosztja a panelt. Majd jön a reflow kemence, ami a forrasztást szolgálja. Fokozatosan fűt fel, fűtőzónák segítségével, illetve vissza is hűti a panelt ( hűtőzóna). Majd ismét konveyor. Buffer (gyűjti a panelt, ha az AOI vagy a minőségellenőr lassabb mint a sor). Konveyor. AOI - vizsgálja az alkatrész beültetését, polaritását, feliratát. Majd egy konveyor, és végül a quaility control -minőségellenőr- az AOI kép és a vizuális munkautasítás alapján ellenőrzi a panelt.
Az SMT gyártáson belül számtalan olyan termék létezik ahol a furat- ill. felületszerelt alkatrészek ugyanazon modulból ültetődnek.

Források

További információk

Kapcsolódó szócikkek
Furatszerelési technológia

Áramköri elemek
Elektrotechnika
Elektronika


Tom is my best friend and the love of my life. I have always been amazed by his ability to stay calm and optimistic, no matter the situation. Tom loves people and people love Tom.
Many people call Tom a friend because he has such an outgoing and charismatic personality. Tom is an amazing dad to our son. He is a hands-on father whose biggest joy is to make our son laugh.
Tom enjoys playing golf, fishing, and playing piano.
Tom has his Bachelors of Arts in Mathematics and is a sales representative in the medical device field.
Vacation spot: Siena, Italy – Jessica and I traveled to Europe several years ago and Siena was my favorite.
Favorite memory together: Going skydiving for my 30th birthday!
Childhood memory: I went on a fishing trip to Canada with my dad and a few friends when I was a teenager. It was a great trip and many memories were made.