Comprehensive verification IP constructed utilizing sophisticated methods for fastest time to verification sign-off Verification IP (VIP) blocks are placed into the testbench for a style to examine the operation of user interfaces and procedures, both discretely and in mix. Many basic procedure and user interface IP makes it possible for verification engineers to examine standard functions, such as system start-up. VIP makes it possible for more in-depth expedition. Due to the fact that of the development in intricacy of system-on-chip (SoC) styles, this is ending up being progressively crucial. VIP can likewise be utilized at numerous phases in a style circulation and by numerous providers to a style task. Requirements for basic user interface procedures are frequently numerous pages long. Figuring out these requirements and properly modeling the procedures is a substantial advancement effort needing deep technical understanding. By utilizing production-proven Cadence ® Verification IP (VIP), your system-on-chip (SoC) styles can be validated quicker, better, and with less effort.
Cadence is the market VIP leader with items supporting more than 40 interaction procedures and 60 memory user interfaces. Cadence VIP suits almost every verification environment with assistance for all significant simulators and verification languages. Our VIP provides the sophisticated functions that you have to optimize your performance and keep tasks progressing. Verification IP are recyclable verification modules that normally include bus practical designs, traffic generators, procedure screens, and practical protection blocks. Each verification IP speeds up the advancement of a total verification environment to lower the time to very first test.
Confirming IP is a more intricate job than developing IP. Clearly, IP suppliers should confirm the proper performance of the core. The supplier needs to likewise confirm the core for compliance with the user interface requirement. These jobs would be simple if user interface IP were a one-size-fits-all service. The other element of IP verification enters into play throughout combination and system-level verification by the consumer once the IP is incorporated, the consumer needs to validate system-level performance and confirm target efficiency by creating application-specific traffic. To make sure interoperability, it is likewise crucial to design other gadgets that may interact through the user interface in the last system. All these jobs, some redundant, represent a considerable concern for the IP supplier and consumer. IP suppliers can not pay for to establish a specialized verification service for each client's special style and verification environment.
These might be internal groups dealing with a brand-new style that is targeted at being the very first to execute a brand-new requirements (progressively typical to match the broadening choices required on mobile phones) or 3rd parties who wish to bring style IP items to market ahead of, or concurrent with, the ratification of a requirements.
This group wishes to provide a requirements in its early phases and might well be the clients of the third-party business in the very first classification. They are especially worried to confirm a brand-new innovation in higher depth as it might not have actually been utilized extensively and there are as a result problems relating to self-confidence.
This group desires each IP block to work individually and however likewise to examine how numerous blocks communicate with one another inning accordance with the requirements and abilities of each spec.
With the combination of several subsystems and offered the size these days's common SoCs, this group has 2 issues. The very first is the interaction in between numerous blocks. The 2nd is that by this time, the style size has actually ended up being so terrific that they might have to use constraint-driven verification strategies and desire some type of velocity. VIP is upraised foundation that you can drop into your circulation to carry out a predefined function. Rather of ending up being blocks of the style itself, Verification IP obstructs ended up being parts of the testbench utilized in verification. Like other IP, verification IP can, in theory, be developed for reuse or accredited from 3rd parties. Verification of a big SOC styles normally takes more than 50% of the total task life process and is done at numerous phases – Verifying smaller sized sensible blocks, Verifying a group of reasoning parts at a sub-system level then verification of the whole SOC chip.
VIP blocks can assist in all these levels of verification as simulation designs for the real style IP. VIP obstructs usually includes bus practical designs, stimulus generators, procedure displays, and practical protection blocks. Because a great deal of market style testbenches follow various languages (like SystemVerilog, C, specman) and methods (OVM, UVM), these VIPs are typically developed as configurable parts that can be set up and quickly incorporated into various verification environments. Drop-in verification IP is a legendary animal: Unlike style IP, VIP users do not have the high-end of 'drag and drop' executions that need reasonably little procedure knowledge on the user's part. Verification engineers require procedure understanding to examine that protection is total, effectively translate outcomes and debug unforeseen habits. Verification engineers need quick access to details and understanding of the procedure to rapidly ramp on brand-new procedures and brand-new variations of existing procedures.
Procedures are ending up being still-more complex and various, and the days of composing your own VIP with the attendant danger of spec misconceptions and continuous assistance load are long gone. Their VIP should have the abilities to minimize the procedure knowledge required by users. Picking the ideal VIP supplier is an important option for job success. The obstacle depends on getting VIP that has the best mix of qualities. With that objective in mind, here is my take on 10 broad 'need-to-knows' and, within them, some particular concerns to ask suppliers. They must assist you discover VIP that optimizes the efficiency of your verification.


On Nov. 20, 1969, a group of Native American activists landed on Alcatraz Island. It wasn't the first time they had done so, but this time it stuck: they began an occupation of the island that lasted for more than a year.
Sure enough, that anger and activism was the subject of a Feb. 1970 TIME cover story that, while it did not entirely avoid indulging in stereotype, acknowledged that the prejudice that Americans experienced at that time was "as painful a fact to Indians as it is to blacks" and that "Indians suffer just as harshly from biased history books." As the story noted, textbooks used in American schools at the time portrayed indigenous people as mentally "deadened" and treated the coming of the Pilgrims as a purely positive step for everyone involved.
One of the men at Alcatraz was John Trudell, the late activist and artist who, during the occupation, served as a spokesperson for the group. Trudell was then a chairman of the American Indian Movement during a portion of the 1970s.


Your brand new SodaStream machine just arrived and you're getting ready to make your first homemade soda. You're excited to start saving money and maintain your soda addiction without producing any more waste.
Before you start making your own soda, stop and make sure you know how to take proper care of your SodaStream machine. These machines are pretty durable but anything can break down. The bottles should also be cleaned properly on a regular basis to make sure you don't end up mixing flavors by accident.
Luckily the SodaStream machine is actually pretty easy to clean. All you have to do is remove the CO2 canister and wipe the machine carefully with a soft, damp cloth. The water you use should be lukewarm. You shouldn't need anything other than water to keep your SodaStream machine clean.
How you clean the bottle depends on what kind of bottle your SodaStream machine came with. If you chose one of the models that uses glass carafes, you're one of the lucky ones. The glass carafes are designed to be easily washed and they're even dishwasher friendly.
If the model you chose came with plastic bottles you're not so lucky. The SodaStream plastic bottles are designed to last for three years, but they aren't dishwasher friendly. Since they're shaped like normal pop bottles, they're not easy to clean either.
If you've been using the bottle purely for sparkling water and you haven't used it many times, you can probably get away with a blitz clean. Start by filling the bottle halfway with water and tip it out. Do this a couple times to make sure the bottle is thoroughly rinsed, then fill it 75% with water, close it, and shake it vigorously. Empty it again and rinse it one last time.
By now the water coming from your tap should be scalding hot. Rinse your bottle cap thoroughly and get back to making soda.
If you've been using the bottle for a while or you let it dry out with SodaStream residue still in the bottom, you'll want to do a full clean. This is very similar to the blitz cleaning process but a little more intense and involves using dish soap.
To start, fill your bottle with hot, soapy water and pour it out. Fill it again and this time screw on the cap. Shake the bottle vigorously for a few minutes and pour most of the water out. You can scrub the bottle now if you really want to, but it should be fine if you shake the remainder of the soapy mixture around a bit more and pour it out.
You'll want to make sure you rinse thoroughly with extremely hot water. Nobody likes soapy soda and too much soapy residue can even reduce the amount of fizz you're able to put in your next drink.
The most difficult part of maintaining your SodaStream machine in perfect combination will probably be resisting the urge to carbonate everything but water. Cleaning the machine is extremely simple and while cleaning the BPA free plastic bottles isn't quite as easy, it's a fairly simple process that won't take up much of your day.
Can you suggest the best way to get rid of stains left behind in the soda stream bottles, especially after orange flavoured soda.
Hey Noel! Your best best is try using a bit of lemon juice to remove stains. It can sometimes work better than soap because it's more acidic. Avoid using bleach as it can damage the bottle.
It's also a good idea to clean the grooves of the cap and bottle with a toothbrush. I find they inside of to be the dirtiest part, because it's the hardest to clean (and your method won't actually clean it).
I have the same problem… the caps get gross! I feel lime i need to somehow remove the rubber ring on the inside of thecap to thoroughly clean under it but I haven't been able to. Any advise?
Use something pointy like a toothpick, being careful not to damage the gasket, and working on the inside edge (not the outside threaded edge), slip the toothpick under the seal, then work your way around, lifting the seal up. Eventually it will pop out easily.
Then you can clean all the mould! Ick.
The caps are dishwasher safe and that can get the mold that gets under the gasket and into the grooves.
The bottle lid gasket can be taken out by using a letter opener, be gentle and it will eventually come loose. Thing is mine came out and it was holding the most of the smell. Well cleaned and see what comes of it. Hate to buy new one as reviews are not as good as original.
Hi Julie! We broke down and tried to carbonate white wine. Ugh, what a mess! Now I need to know if I can submerge it in water to get it really clean. Do you know if that will hurt it?
Oh no! I've never tried submerging one before so I'm not sure what would happen. Since there aren't any electrical components, my gut says it's ok, but I can't say for sure!
Hi Christy! We made the same mistake and I was wondering if you tried submerging it in water? Did it worked? Thanks!
Haha! I did the same! Not a champagne maker!
Maybe next time just carbonate some water to add to the wine 🍷 It says right in the booklet to only carbonate water.
Yes you can submerge it. I once tried to carbonate water that had fruit in it. I strained out the actual fruit but there was still some sugar or maybe a strawberry seed in it which was sucked back into the Soda Stream clogging the nozzle. The soda stream people said that sadly I would probably just have to junk it. But I decided to soak it in luke warm water instead– had nothing to lose at that point. It worked great.
I made the error of carbonating pomegranate-cranberry juice. Huge mistake, with more than half the fizzy juice going every which way. I made the added mistake of not immediately carbonating plain water to help clear the nozzle, which might have saved the day. Anyway, by the next day, the machine went through the motions, but no CO2 came out through the nozzle.
There is an amazing lack of information on this problem anywhere on the web, and an even bigger lack for the Fizzi One Touch, which is the model I have. Okay, so this is what I did: I took out the gas canister and unplugged the machine to avoid any possibilities of disaster (probably unnecessary, but not a big deal and it prevented me from inadvertently doing anything else stupid). I then adapted Karen's advice, above, to this machine, which should not be submerged since it has an electrical component.
What I did was fill a bottle almost to the top with water, to submerge as much of the nozzle as possible, and then put it in the machine and let it sit overnight. My hope was that the water would clear out whatever residual juice was blocking the nozzle. Next morning I took out the bottle, poured out enough water to get to the fill line, put it in the machine (into which I had reinstalled the gas canister and plugged in), and voila! — it worked just like new. Whew, what a relief!
There is still some residual juice stuck up in the mechanism, but I'm inclined to let sleeping juice lie and just be glad I was able to salvage the machine. Meanwhile, no more carbonating anything but water for me! Hope that helps some out there in SodaStreamLand.
Hi, I recently purchased a sodastream at Goodwill for $4 (go me!).
How do I remove all of the previous owner(s)' mouth germs from the plastic soda stream bottle?
Is there anything else I should watch out for with a pre-owned soda stream machine?
Great find! Aside from dish soap, you could try cleaning it with a hot water and vinegar solution. Vinegar is very good at removing stains and odors.
I bought my soda stream off of OfferUp. I cleaned the machine with Clorox wipes and water. It came with a couple bottles, but I played it safe and bought new bottles.
At the nozzle where the carbon comes out of, is a little clogged. Is there a way to remove and clean inside that nozzle cause its barely coming through?
The best bottle cleaning solution is…Vinegar! Fill bottles 1/2 full with vinegar then warm tap water to 2/3 full, close and shake vigorously. Let stand overnight. Then thoroughly rinse with warm water. Continue as usual. Most store vinegar is 5% acetic acid which is more than potent enough to remove all residues and funky tastes but harmless to gasket seal in cap. Have 6 bottles. Use two full ones each day for 5 years. Yeah, this works!
I have three soda stream bottles and two machines! We love it!! It has been about two years now we have been using the machines and bottles. I have rinsed the bottles each time I have used them….with warms soapy water as recommended. Lately, I have noticed a foul smell coming from the bottle lids. As hard as I have tried, I can not seem to remove the plastic o-ring to clean under it. Should I just do away with the bottles? Or can I purchase new bottle lids?
The inside of my plastic bottles has a cloudy residue that doesn't come off with soapy water. Any ideas?
I'm really not clear on whether you can carbonate other than just plain water. The directions / instructions aren't clear or I am missing something. If I put essential oils in can I do it before or after carbonation?
Officially you shouldn't carbonate anything other than plain water with a SodaStream (but sometimes people do it anyway). If you are adding essential oils, I would do it after you carbonate the water.
Have you guys ever tried cleaning the black rubber washer around the nozzle? (the part that encloses your bottle opening when you carbonate) I just tried wiping it with a paper towel and is a dark black residue that comes off! No matter how many times I wipe, it's still there. It's like it part of the rubber that just keeps coming off.
How do you get mold out of the bottom? I bought a bottle brush but bristles were too soft. Tried vinegar and baking soda and various other things, no go.
Michelle, Take no chances with mold. Buy a new bottle. And in the future, carbonate only water and let the bottle completely dry out with cap off after rinsing it with warm water.
I too have the mold (I'm assuming it's mold. It's black) at the top of the nozzle, inside the mechanism. I tried leaving it overnight in a slight solution of bleach. No good. I'll try vinegar but based on other comments I'm not optimistic. Just the thought of that stuff at the top of the nozzle makes me not to want to use sodastream (which I love BTW).
My soda stream bottles have developed a strong chlorine odor. I only carbonate filtered water in them. I wash them in between by either rinsing or with a little dish soap and warm water. (It says not to use hot water on the bottle) So I got rid of the bottles that were past their expiration date and bought new ones. I have the same problem with the new bottles. I can't figure it out. Our other reusable water bottles (the ones we just put filtered water and ice in) don't smell like that. Has anyone else had this issue?
I am also wondering how to get rid of mold/mildew from the caps, under the rings, in the bottles and around the screwtops. thanks.
Mildew smell every time I use it after a hot and humid month and two days of no use because I ran out of air! GROSS! Can't see how to take it apart to clean inside, but it's definitely got mold inside. Safe to run vinegar????
One can scrub and polish the inner surface by adding a bunch of salt to an empty bottle and shaking vigorously.


Replacement Plutonite® impact-resistant lenses for various Oakley eyewear frames. Featuring High Defintion Optics® and XYZ Optics® geometry to eliminate distortion and enhance sharpness and clarity.
Bought these lenses for overcast days during CX season. Fit into frame with no issues. No fogging or other issues.
Its great for the early grey mornings or low light evening when you are getting back from long rides. But, its dark enough for a really sunny days. But, its the best switchable frame I had so far.


text:
Boomer Bytes #73: The Aging Brain-Really?
Published Friday, June 5, 2015 at 9:49 am
Editor's Note: Below is another column in Steve Canipe's series called Boomer Bytes. The column, as the title suggests, will focus on a variety of topics that may be of interest to baby boomers, those born between 1946 and 1964. But Canipe also hopes to start a conversation with younger generations, too. Check out an introduction and Canipe's (first self-titled) column here.
See second column – Are We Really Old? – here.
See third column – Cars and More Cars – here.
See fourth column – Getting Educated – here.
See fifth column – Home Alone? – here.
See sixth column – Death – here.
See seventh column – They're Playing Our Song – here.
See eighth column – Driving: Knowing When To Quit – here.
See ninth column – Hobbies: What's Your Favorite – here.
See 10th column – 'The Last of Life, for which the First was Made' – here.
See 11th column – Volunteeering – here.
See 12th column – Duck and Cover – here.
See 13th column – Providing for the Future – here.
See 14th column – Here We Go Wandering… – here.
See 15th column – State of Schools – here.
See 16th column – Our War – here.
See 17th column – Behind the Curtain – here.
See 18th column: Our Mind
See 19th column: Change
See 20th column: Memorials
See 21th: When is Old?
See 22nd: Roles
See 23rd: Becoming a Dad
See 24th: Where Are My Roots?
25th: Is it our fault?
26th: Getting There From Here
27th: Oriental Competitor
28th: Russia – The Evil Empire
29th: India A Sensory Experience
30th: Tanzania–Land of Kilimanjaro
31: Drug Use
32: Are We Being Ripped Off?
33: Reunions and Such Things
34: Our Friends and Language
35: Climate Change Reality
36: The Lure of Leisure
37: Photography – The New Way
38 – Helping Others with Your Skills
39 – Are We Radical or Radical Enough?
40 – Can You Teach Boomers New Tricks?
41 – Play Ball
42 – Aggravations to Make You See Red
43 – Propaganda: Twisting the Truth
44 – Do You Have the Packrat Gene?
45 – Being Thankful
46 – Remembering Grandparents
47 – Using Our Brains or Losing Them
48 – What's a Family?
49 – Pets Becoming Peeves
50 – Christmas Memories
51 – Resolutions
52 – Retrospective for Boomer Bytes
53 – Styles
54 – Commemorations and Remembering
55 – Baby Baby Boomers
56 – Hoarding: Tripping Over Our Stuff
57 – Hate and Anger
58 – Alzheimer's Disease – While I Still Can
59 – Rebirth in Spring
60 – We Are What We Eat
61 – March Madness Really?
62 – Cell Phones and Other Gadgets
63 – Starbucks, Race and Other Things
64 – Grandkids and Other Fun Things
65 – Memories of Younger Times
66 – National Parks: They Are Ours
67 – Traveling to Learn
68 – May Day – What's That?
69 – Will You Live Too Long?
70: Eldering: What is that?
71: Foundation of Western Civilization
72: Livable Communities
The Aging Brain – Really?
By Steve Canipe
Ok, so our whole body is getting old – our muscles, our eyesight, our hearing, our lungs – you get the picture. Why would our brain be any different?
We know that through exercise we can stay in better physical shape, keeping our muscles and joints limber. Using exercises regimes like yoga and Tai Chi we can help ourselves be more mobile. But is there something that we can do to help our minds stay in shape? Are there exercises we can do to help?
Canipe
Several big players in the brain flexibility think we can exercise the brain – like Lumosity (www.lumosity.com/), Brain Metrix (www.brainmetrix.com/), and Brain HQ (http://www.brainhq.com/why-brainhq/about-the-brainhq-exercises). Some of these offer free tips and some charge for it. But the bottom line is that there does appear to be things that can be done to keep the brain more active and functioning well.
Dr. John E. Morley, director at St. Louis University's Geriatric Medicine department wrote in the book The Science of Staying Young that word games help brain health but listed 11 other things you can do to keep your brain active. From his book, the following listing: 1) Test your recall. Make a list of anything — and then after an hour try to remember each item; 2) Learn to play a musical instrument; 3) Do math in your head; 4) Take a cooking class; 5) Learn a foreign language; 6) Create word pictures—like Wuzzles (http://goo.gl/DDao1M); 7) Visualize the spelling of a word in your head, then think of other words that begin the same; 8) Draw a map from memory: 9) Challenge your taste buds: 10) Refine your hand-eye abilities; 11) Learn a new sport.
Other researchers suggest that one should keep socially active and not become a recluse. Being around others seems to cause more cognitive functions to be maintained. Certainly doing the right things physically, like getting sufficient sleep, is a key as well. Dr. Dan Blazer a research professor emeritus at Duke University says that the jury is still out on the computer-based trainings mentioned above work or not.) They may be fun but not necessarily really help in functioning. (http://jama.jamanetwork.com/article.aspx?articleid=2276710 This research was reported in a popular press article by Lauran Neergaard of the Associated Press found in the New York Times (http://www.nytimes.com/aponline/2015/04/14/health/ap-us-med-aging-brain.html)
It has become possible to find lots of different recommendations for keeping the brain sharp. While the brain like almost like every other body part slows down with age, it also can draw on accumulated wisdom that is stored in the neurons. The slowdown is not like Alzheimer's disease but a natural process. The neurons don't die they just don't function as well as they have during their younger years. Scientists at Duke University noted that there is a wide variability in the way individual brains age. It is these inevitable slowdowns that make Boomers and other older people more likely to fall for scams, have issues driving, or be less technologically savvy.
Scientists suggest that anyone noticing these slowdowns should be checked out simply to rule out medically treatable issues like cancer and other tumors as well as Alzheimer's. There can be less serious issues that can affect mental sharpness including high blood pressure, diabetes, and even some medications—like anxiety or sleep drugs, antihistamines, or even drugs for bladder issues.
I suspect we have all experienced individuals who are no older than we are, who have lost their ability to process even relatively simple instructions. By the same token, we may have experienced other individuals who have seemingly been on top of their game well into their ninth decade of life. I certainly have personally noticed this in my family and wondered why? It is not just an example of people with more education. I don't have scientific data but merely observational data. My Grandfather Farmer passed away at 95 and while he was relegated to using a cane and not being particularly mobile, was still functioning at a high cognitive level. He never completed elementary school due to having to work on the family farm. He was born in the late 19th century. He was an avid reader of the Bible but not much else. But he was aware of news of the world and could discuss it intelligently.
There has been some research on what is termed brain plasticity dealing with the ability to problem-solve (among other things). Some research seemed to show that playing the old game "Tetris" created better neural pathways and slowed and in some cases seemed to reverse some forms of dementia. (http://thebeautifulbrain.com/2011/06/the-neuroscience-of-tetris/) If you are not familiar with Tetris, (http://tetris.com/) it is a game widely available on many platforms, including smart phones and tablets, that is a special recognition game. Blocks of various sizes drop down and the idea is to build complete rows which will then "blink" out of existence. The player has the ability to rotate the various shapes to help build complete rows. There are free versions of the game which can be found by a quick Internet search.
With more brain research, we may find that there are definite do's and don'ts that we need to follow to keep our brains active. But until the research settles out a bit, perhaps we should try several different things—like the computer brain games, working puzzles, being social, taking courses, etc. It is pretty obvious that none of the suggestions will hurt and some may help keep the old brain stem functioning well!
I suspect we have all experienced teachers who seemed way older than us but who had a youthful outlook on life. Maybe this is telling us something – by acting and being around young people maybe we do stay younger. In last week's column I discussed livable communities for boomers. One of the things was not to be totally age segregated. I know that when I am around folks who do a lot of complaining about their aches and pains my own aches and pains seem worse. Being around folks who are more active makes me more active. Maybe this is due to my natural competitiveness or maybe there is something to be said for "group think" – act young and feel young!
It does not mean that people get to avoid the pain. But what it is, may be illustrated by the quote from Shakespeare's Hamlet "…Whether 'tis nobler in the mind to suffer the slings and arrows of outrageous Fortune, or to take arms against a sea of troubles, and by opposing, end them?" I read this to be don't let things control you, rather control them and by doing so end their power.
Once during a group bus trip to Alaska, many years and some decades ago, there was a fellow on the trip who suffered from arthritis, very bad arthritis. He could not always do what the rest of the group did and stayed on the bus. Someone asked why he didn't just stay at home and rest? His comment was simple and bore out what Shakespeare noted; he said that he could stay at home, see nothing different, and hurt or he could be on the trip, hurting sometimes but seeing lots of new things. So his response was clear – he would not give in to the slings and arrows that had given him painful arthritis!!
What about you? Are your cognitive functions deteriorating too fast? Are you fearful that they will? Has anyone told you that you are being forgetful? These are questions that probably cause all boomers some concerns – especially for the oldest of us (like me). I know I try to stay active and mentally alert – I am still working full time, now for Walden University, an accredited fully online school. I have been working with them since I began part-time in 2002 when I was a mere 56!! I've had a number of positions with the University, where I have had to teach and also deal with the ambiguity of administrative functions. This does, I believe, help keep me young. At some point, I will retire from this work and then go on to what, I don't currently know. Maybe write a book or convert all my columns into a book. Take some classes at the University or delve further into my photography hobby. I honestly don't know at this point.
What about all you readers? What is your fear? What are you doing to stay mentally alert? Do you already see some decline? Please share your thoughts, fears, and plans with us all via the space below or send me a private email at [email protected].
« App Theatre Group Enters Publi...
Explore the Local Arts Communi... »

redpajama_set_name: RedPajamaCommonCrawl


Banks and Savings and Loan Associations and arrange to have funds transferred to an affiliate or recommended bank in the area.
Memberships in Organizations and Professional Associations.
Credit in your new area by asking your local credit bureau to send your rating to one located here.
Communication with utility companies to assure there will be no delay in obtaining service.
Defrost refrigerator and freezer 24 hours before leaving: use a few pieces of charcoal to reduce odors.
Collect items that you have loaned, had cleaned, stored or repaired.
Arrange for transportation of pets if you plan to send them via air or railway express; consider boarding them while you settle into your new home.
Have reliable servicemen prepare your appliances for shipment; consider buying a new TV antenna rather than dismantling and moving our old one, even if your sales agreement permits.
Review moving plans with your moving company representative; insurance for packing and unpacking; arrival date; payment agreement; shipping papers.
Leave your address in a conspicuous place so that new occupants can forward any mail inadvertently delivered to you old address or send change of address to local post office.
Prepare "survival" kit for use upon arriving in your new home; light bulbs, bathroom articles, small tool kit, linen, flashlight, instant coffee, paper plates and cups, etc.
Obtain a new drivers license.
Check area for car inspection and registration requirements.
Visit the city and county office and register to vote.


text:
Overview PBX integrations
Overview WAM - Modules
Certificates PBX
Integrations PBX
Integrations protocol
Ascom Wireless Solutions
http://www.ascom.ch
Ascom Wireless Solutions (www.ascom.com/ws) is a leading provider of on-site wireless communications for key segments such as hospitals, elderly care, independent living, manufacturing industries, secure establishments, retail and hotels. More than 75,000 systems are installed at major companies all over the world. The company offers a broad range of voice and professional messaging solutions, creating value for customers by supporting and optimizing their Mission-Critical processes. The solutions are based on VoWiFi, IP-DECT, nurse call and paging technologies, smartly integrated via Ascom Unite into existing enterprise systems. The company has subsidiaries in 13 countries and 1,200 employees worldwide. Founded in 1955 and based in Göteborg, Sweden, Ascom Wireless Solutions is part of the Ascom Group, listed on the Swiss Stock Exchange.
http://www.axis.com
Axis enables a smarter and safer world thanks to the development of network solutions. As the market leader in network video, Axis offers video surveillance products and services as well as access control and audio systems. Axis speakers are complete high-quality audio systems. They are perfect for background music as well as recorded and live announcements i.e. in shops, offices, industries and hospitals. Axis has over 3,000 motivated employees in over 50 countries. The headquarter of the company founded in 1984 has its seat in Lund, Sweden. The Munich office takes care of the DACH region.
http://www.avaya.ch
AMX, CMX
Avaya is a global leader in business communications systems. The company provides unified communications, contact centers, data solutions and related services directly and through its channel partners to leading businesses and organizations around the world. Enterprises of all sizes depend on Avaya for state-of-the-art communications that improve efficiency, collaboration, customer service and competitiveness.
http://www.alcatel-lucent.ch/
Alcatel-Lucent's vision is to enrich people's lives by transforming the way the world communicates. Alcatel-Lucent provides solutions that enable service providers, enterprises and governments worldwide, to deliver voice, data and video communication services to end-users. As a leader in fixed, mobile and converged broadband access, carrier and enterprise IP technologies, applications, and services, Alcatel-Lucent offers the end-to-end solutions that enable compelling communications services for people at home, at work and on the move. With 79,000 employees (after the completion of the Thales transaction) and operations in more than 130 countries, Alcatel-Lucent is a local partner with global reach. The company has the most experienced global services team in the industry, and one of the largest Innovation and Technology organizations focused on communications. Alcatel-Lucent achieved adjusted proforma revenues of Euro 18.3 billion* in 2006, and is incorporated in France, with executive offices located in Paris.
http://www.dialogic.com/de
Dialogic develops products and technologies for service providers and enterprises that enable reliable, seamless, and efficient communications across countless devices on any network. Today, networks using Dialogic technology carry more than five billion minutes of traffic per month, and services built on Dialogic products are used by an estimated two billion mobile subscribers worldwide. For service providers, Dialogic supplies a full suite of products that deliver high-demand services over mobile, VoIP, and traditional networks. For the enterprise, Dialogic focuses on any-to-any connectivity and IP-enabling its traditional voice and fax products to smooth the move from TDM to an all-IP environment.
http://www.mitel.ch
Mitel is headquartered in Concord, Ontario, Canada. Mitel globally develops and markets Internet Protocol (IP)-based as well as traditional communications networking products and systems. Mitel's products include a full range of VoIP solutions including communications servers, gateways, telephone terminals and advanced software applications for business and residential markets. Aastra ranks 3rd in the European enterprise telephony market.
http://www.pikatechnologies.com/
PIKA Technologies designs and manufactures computer plug in media processing hardware and software building blocks that connect a computer system to both TDM- and IP-based networks to provide advanced voice and fax services. For almost two decades PIKA Technologies has been serving companies around the world that require voice cards to design sophisticated phone services for recording systems, voice service applications, fax broadcast and PC-PBX systems. The company has built a reputation for delivering innovative products and exceptional technical support by working closely with its customers. Headquartered in Ottawa, ON, Canada, the company has ranked in The Branham300, an authoritative ranking of successful Canadian high tech firms, for five consecutive years.
http://www.spectralink.com/
Spectralink, a global leader in wireless solutions, solves the everyday problems of mobile workers through technology, innovation and integration that enable them to do their jobs better. By constantly listening to how customers move through their workdays, Spectralink is able to develop reliable, enterprise-grade voice and data solutions and deliver them through a powerful, durable device.
http://www.unify.com
Unify - formerly known as Siemens Enterprise Communications - is one of the world's largest communications software and services firms. Our solutions unify multiple networks, devices and applications into one easy-to-use platform that allows teams to engage in rich and meaningful conversations. The result is a transformation of how the enterprise communicates and collaborates that amplifies collective effort, energizes the business, and dramatically improves business performance. Born out of the engineering DNA of Siemens, Unify builds on this heritage of product reliability, innovation, open standards and security to provide integrated communications solutions for 75% of the Global 500. Unify is a joint venture of The Gores Group and Siemens AG.
Swiss made alarmserver / cti solutions in sections health care, industry, public administrations, tourismus, bank, assurances, etc.
1995 © ATT AG. ALL Rights Reserved - Swiss Made Products Contact - Support - Data privacy statement


text:
S-S-S-Signs!
January 27, 2011 January 27, 2011 / Rivergods
Well, it's official, we have finished mixing our new record Signs; we are commencing mastering, and we EVEN have a release date (Saturday, March 26)! We're going to have a grand ol' release party at the Rose Barn at the O'Neill Theater in Waterford, and we hope you'll be there to celebrate with us. Opening the show will be our good friends Black Marmot from Boston, MA. More information and the latest updates here.
But BEFORE that, we've got a bunch of other exciting recording news… this weekend, we're releasing a new single as part of the Hygienic Weekend Long One Hundred compilation coming out of New London, CT. The song is 'Big C' (a different version than what will appear on 'Signs'… listen here) and in the spirit of the Hygienic vibe, comes complete with a spoken verse (read: rap!) from MC Gabe Chandler of the hip-hop/jazz unit Above/Below. And the B-side? None other than Radiotricity's (remember them?!) "Aunt Sally"… Check it out here.
Lastly, GIGS… some other upcoming shows… the Rivergods will throw down a short acoustic set at the Hygienic Hootenanny this Friday, Jan. 28 at 8 p.m. at Muddy Waters. On Friday, Feb. 4, Ben will appear in a very special tribute concert called 'Everybody's Digging Dylan at the Katherine Hepburn Theatre in Old Saybrook, CT. On Friday, Feb. 18, Nancy will play solo at the Vanilla Bean Cafe in Pomfret, CT, part of their monthly Songwriting Sessions series. And Friday, Mar. 4, the Rivergods will plug in at the Bank Street Cafe with very special guests Fiesta Brava from Northampton, MA. More info here.
That's all for now… hope you're staying warm out there in winter wonderland.
← Back at the Blue Collar Happy Hour Jan. 14!
Mastering 'Signs' →


text:
Your Votes Got Us Into The Final Round of The Ideas for Change Competition
Mar 4, 2010 | News | 0 comments
Now your votes are needed for our idea, "Support the California OneCare Campaign for Single Payer Health Care," to be one of the top 10 winners of the final round of competition.
If our idea makes it into the top 10 in this final round which ends on March 12 at 2pm Pacific Time, the resources of the Change.org team, their partners, and their 1 million community members will be mobilized to help us as we build the grassroots movement for single payer in California.
To provide an equal playing field, each idea started yesterday with zero votes. This means that anyone who voted for our idea in the first round will have to vote again in the final round in order to be counted.
With the 365 Ad Campaign which began Monday, an unstoppable California grassroots movement, and the help of single payer supporters all over the country, the California OneCare Campaign will defeat the insurance industry – first in California and then across the nation.
To place your vote go to:
http://www.change.org/ideas/view/support_the_california_onecare_campaign_for_single_payer_health_care
Instructions: Click on "Vote Now". You'll be asked to register to confirm your vote; if you voted in the first round, you already have an account, so you'll be asked to "click here"; once you do that, your vote is counted. If you're not already registered, please fill in the form, which will generate an email. Once you respond to the email, your vote will be counted.
ONLY 10 DAYS LEFT TO VOTE
Remember, the deadline for voting is on March 12 at 2pm Pacific Time.


Now it's time to Upgrade my Linux Laptop to PERFECTION!!!
What Linux Distro is on this laptop ! ?
Hey…!!! Good idea,. I've used the USB's, this would be much better…!!!
Nice :D. You can then just buy an enclosure for the ODD which you took from the laptop so you can still use it as an external ODD 😀 ….
Great stuff man!! Im running a 2700X/1080Ti video editing rig that I dualboot W10 Pro/Mint 19 Tara on.Davinci Resolve is so damn good these days, I find myself in Windows less and less. Think the days of going 100% Linux is coming!


Kale Herbert's appointment as head coach of Hamilton Wanderers has received national media coverage with the NZ Herald website and Hamilton News leading the way.
Hamilton Wanderers Football Club has had to make another coaching change after the unexpected departure of Juan Roman on Saturday.
The club has signed Kale Herbert, who is the son of former All Whites and Wellington Phoenix coach Ricki Herbert. Read more.


United Wound Healing (UWH) provides team-centered wound care, a unique teamwork model that allows the organization to work side-by-side with skilled nursing, assisted living, and family home caregivers on weekly wound care rounds. Together, UWH teams work to enhance patient care while decreasing costs, reducing staff paperwork, improving quality outcomes, and increasing compliance with federal regulations.
As a relatively new organization, United Wound Healing wanted to get started on the right foot when building their customer base and managing their accounts. They knew they needed a CRM platform that could handle the various aspects of their business operations and provide a central database for account management. UWH was able to leverage several of PowerObjects' PowerPack add-ons for Dynamics 365 to enhance functionality.
Are you looking to send bulk emails from Microsoft Dynamics 365 and track bulk email statistics back to your CRM contacts, leads and accounts? Then give PowerMailChimp a try! PowerMailChimp is a MailChimp CRM integration tool that connects the powerful, robust, and affordable third-party bulk email platform, MailChimp, with Dynamics 365. Use static or dynamic CRM marketing lists to send out bulk emails such as newsletters, special offers, and more, all from within Dynamics 365.
UWH has utilized many of PowerObjects' PowerPack add-ons to automate their marketing efforts, which has allowed them to focus on their patients, staff, and partners. One of those add-ons is PowerMailChimp, which integrates with the bulk email platform MailChimp, allowing users to send bulk email to contacts directly from CRM.
UHW also uses PowerSurveyPlus, which allows users to build surveys, send them out to their nursing partners, and receive answers back directly in CRM.
PowerMap is an add-on that UWH is planning on leveraging for clustering and bundling services. Because PowerMap allows users to map out prospects within a certain radius, it has the potential for helping UWH to understand where leads are located and penetrate new markets.
The UWH team relies on PowerCalendar to monitor staff requirements and provide important details around scheduling. PowerCalendar gives the staff the ability to view all team member's activities in one calendar directly inside CRM.
"We didn't want to live in Outlook doing that because that gets very busy even with personal agendas. PowerCalendar will be our professional calendar for services and will allow us to click on a button and view an account record. It's great." shared Sherrett.
PowerWebForm is a critical component of UWH's event registration process. UWH hosts wound care seminars to the public each year. PowerWebForm enables them to easily collect seminar enrollments as well as organize and manage leads in their CRM.


Perfect alone or in a grouping with some of the brighter pieces, these square shaped, matte pieces are beautiful. Perfect for planting a succulent, holding an air plant (real or artificial), make great gifts, holds half a bag of M&M's for daily rationing, or make a toast with it as a shot glass. There are so many creative fun uses! Handmade out of resin, glitter and alcohol ink, they are designed, poured, sanded and polished for years of enjoyment.


Update your pregnancy wardrobe with our collection of maternity jackets and maternity coats, including staple styles to on-trend options for any occasion. Find your favourites from chic and practical waterproof maternity coats, to cosy maternity parka coats that are ideal for colder days. Don't forget, there's free Click & Collect available on your favourite pregnancy coat styles!


text:
FAQ: How Large Is Physical Fitness Industry?
1 How big is the physical fitness industry?
2 How much is the fitness industry worth worldwide?
3 How much is the fitness industry worth 2021?
4 Is the fitness industry growing 2020?
5 Why do most gyms fail?
6 What is the biggest gym chain in the world?
7 How competitive is the fitness industry?
8 How old is the fitness industry?
9 Why the fitness industry is booming?
10 Which country has the largest fitness industry?
11 How big is the gym industry in US?
12 Why does everyone go to the gym now?
13 What's next in the fitness industry?
14 Is fitness a trend?
15 How much money do people spend on health fitness?
How big is the physical fitness industry?
The market size of the global fitness and health club industry has been steadily increasing in recent years, exceeding 96 billion U.S. dollars in 2019. Some of the largest health clubs worldwide in terms of revenue include 24 Hour Fitness and Life Time Fitness.
How much is the fitness industry worth worldwide?
The health club industry continues to exhibit strong performance, especially in light of ongoing economic uncertainty. Globally, it generates an estimated US$75.7bn in annual revenue annually from more than 150,000 clubs. Roughly 132m members belong to health clubs worldwide.
How much is the fitness industry worth 2021?
The market size, measured by revenue, of the Gym, Health & Fitness Clubs industry is $37.0bn in 2021.
Is the fitness industry growing 2020?
The employment level in the Sports and Physical Recreation Activities industry has risen substantially over the period between 2000 and 2019 (from around 54,700 to 117,800), however levels have dropped by almost half in 2020, to 61,200, while projections indicate a rise to 133,900 by 2024.
You might be interested: FAQ: How Is Yoga Asana Different From Other Physical Fitness?
Why do most gyms fail?
"Other than being under-capitalized, the biggest reason we see for health club failure is lack of business know-how and lack of proper implementation of sales and marketing strategies," points out Thomas. "Another common misconception that many new gym owners have is that the gym will sell itself."
What is the biggest gym chain in the world?
24 Hour Fitness is the largest privately held fitness chain.
How competitive is the fitness industry?
Competition in the fitness industry is fierce with large, all-inclusive clubs vying against smaller independent gyms. There is also competition coming from other recreational activities and home fitness programs, such as the popular P90X. According to Byrnes, competition is good.
How old is the fitness industry?
The first commercial gym is typically credited to French gymnast and vaudeville-strongman, Hippolyte Triat. He opened his first club in Brussels and then added a second in Paris in the late 1840s. At the end of the 19th century, another gym was established by an entrepreneurial music hall strongman, Eugen Sandow.
Why the fitness industry is booming?
It's evident that public awareness of fitness and wellness has risen because of the shift of focus to a healthier lifestyle and the promotion of the new offerings. Holding a gym membership and spending money on fitness used to be seen as a luxury, but today it has become a part of people's lifestyle.
Which country has the largest fitness industry?
The country with the most gyms is the United States with 41,370 locations. Brazil has the 2nd most gyms with 29,525 and Mexico has the 3rd most with 12,871; interestingly, both countries are not in the top 10 for the highest revenue.
You might be interested: Readers ask: What Are The Physical Fitness Test For Marine Corps Rotc?
How big is the gym industry in US?
In the United States, the fitness club industry brings a yearly revenue of $27.6 billion. Studies have also shown that this revenue has the potential to reach higher values, as the fitness and health club industry continues to increase in popularity.
Why does everyone go to the gym now?
Often overlooked, going to the gym has just as many mental health benefits as it does physical health benefits. Getting your endorphins flowing helps to clear the mind, ease stress and feel re-energised, enhancing your productivity for the day and lifting your mood.
What's next in the fitness industry?
The most important trends have emerged from this study in the fitness and wellness sector at a global level for the coming year. Topping the list for the projected 2021 trends by the annual ACSM's Worldwide Survey of Fitness Trends are the online exercise, wearable technologies and body weight training.
Is fitness a trend?
Like HIIT, functional fitness is expected to maintain popularity in 2021. The focus on bodyweight movements and exercises that actually help you in daily life has proven to be a massive hit with Aussie fitness fans. With less access to gyms and traditional strength training, full-body workouts will take centre stage.
How much money do people spend on health fitness?
The average American adult spends $155 per month on their health and fitness – that's an average of $112,000 in their lifetime!
Posted in Physical Fitness
Quick Answer: What Are Limiting Factors Definition Physical Fitness?
Quick Answer: What Is The Fbi Physical Fitness Test?


Carl Nicks, Jr. (born May 14, 1985) is an American football guard for the Tampa Bay Buccaneers of the National Football League (NFL). He played college football for the University of Nebraska, and was drafted by the New Orleans Saints in the fifth round of the 2008 NFL Draft. He is currently considered to be one of the best guards in the NFL.


Siesta surf forecast is for near shore open water. Breaking waves will often be smaller at less exposed spots.
Offshore winds at Siesta blow from the ENE.
Short Range Forecast: Heavy rain (total 21mm), heaviest during Fri afternoon. Warm air temperatures (max 27°C on Thu afternoon, min 19°C on Sat afternoon). Winds decreasing (strong winds from the SSW on Fri afternoon, light winds from the N by Sun afternoon). Long Range Forecast:Mostly dry. Warm air temperatures (max 27°C on Tue afternoon, min 17°C on Sun night). Wind will be generally light.
The surf report / weather widget below is available to embed on third party websites free of charge and provides a summary of our Siesta surf forecast. Simply grab the html code snippet that we provide and paste it into your own site. You can choose your preferred language and metric/imperial units for the surf forecast feed to suit users of your site. Click here to get the code.
The above surf forecast table for Siesta provides essential information for determining whether the surfing conditions will be good over the next 7 days. A general guide to surfing at Siesta can be found by selecting the local surf guide option on the grey menu. Our Siesta surf forecast is unique since it includes wave energy (power) that defines the real feel of the surf rather than just the height or the period. If you surf the same spot (Siesta) regularly then make a mental note of the wave energy from the surf forecast table each time you go. Very soon you may start to choose your surf days based on the wave energy alone combined with our forecast of favourable offshore wind conditions. Our star ratings will help here and of course you will also find the usual wave height and period predictions on our surf forecasts as well as a full break down of the swell components under our advanced users option (to reveal that, click the little Einstein character under the tide times).
Further information to help with frequently asked questions about our surf forecast for Siesta may be found under the help tab on the top menu and also by moving your mouse over the question marks on the surf forecast table itself. Please always bear in mind that the forecast is for near-shore open water and local factors at each surf break influence the actual breaking wave height, such as the beach / reef profile, water depths offshore and shelter.
Siesta is 7 km (4 miles) from the city of Bayshore Gardens. If you plan a vacation in Gulf Coast, Florida, look for hotels and other accommodation in Bayshore Gardens. Bayshore Gardens has rooms for a wide range of budgets as well as car hire and transport links.


text:
Home Business Apple to go HULU!
Apple to go HULU!
Apple Inc. is to be a potential bidder for the online video-streaming service, Hulu, a person close to the situation said Friday.
Hulu, which is owned by Walt Disney Co., News Corp., Comcast Corp.'s NBC Universal and Providence Equity Partners, started presenting its financial information to interested bidders late last month, after an unsolicited offer prompted its board to look for other offers. They began preliminary sale talks with about a dozen potential buyers.
In early July, search giant Google Inc. was said to be among about a dozen companies in talks to potentially buy Hulu. Yahoo Inc. is also believed to be interested.
The online video service streams movies and TV shows from broadcasters ABC, Fox and NBC to computers and – for a monthly fee – to a number of Web-connected mobile devices such as smartphones and tablet computers. It expects its paid service, Hulu Plus, to have over a million subscribers by the end of the summer and its CEO, Jason Kilar, has said it is profitable.
Hulu acquisition could bolster Apple?s iTunes store, which provides videos users can rent or buy, but does not currently stream content or offer a subscription streaming service. It could also help the Cupertino-based iPhone and iPad maker as it spars with competitors such as online video pioneer Netflix Inc., which offers both a DVD-by-mail and video streaming service, and Google Inc.'s popular YouTube video streaming site, which streams free, ad-supported videos and rents movies from several major studios.
An added advantage being that CEO Steve Jobs, who is currently on medical leave, already has a connection with one of Hulu's owners: He's The Walt Disney Co.'s largest shareholder and a member of its board.
However, if Apple – or any other company – were to buy Hulu, there's no guarantee it would be able to continue streaming content from the company's current owners. A buyer may have to reach a new deal in order to license the content.
Forrester Research analyst James McQuivey said key to any deal involving Hulu would be an agreement for the continued streaming of its current video content. And if, as many analysts expect, Apple is developing its own TV set, the addition of Hulu would put the company in an "amazingly powerful position," he said.
Hulu's content combined with the iTunes subscription model would create a serious competitor to Netflix, which has been the subject of a lot of vitriol recently due to a planned price hike.
If Apple can manage to pick Hulu up, the company would have a subscription-based service that, if treated right, could easily rival what Netflix offers consumers.
Hulu on the top
Hulu has reached a dizzying level of popularity among users by offering easy and free online access to episodes of hit TV programs.
In a short time, Hulu has exploded into one of the top Internet video destinations. It now attracts some 27 million users every month, according to ComScore Video Metrix.
Talking about first quarter results, Hulu revealed that it was on track to hit $500 million in revenues this year and had 50% more advertisers in the first quarter of 2011 than the same period in 2010.
On?Hulu?s blog, Kilar discussed results from the first quarter, reporting that the ?content community? will earn about $300 million through Hulu in 2011 and that the platform now boasts 289 advertisers, up from 194 in Q1 2010.
The growing popularity of the subscription plan might make industry interest in Hulu grow, and seeing the potential interest by big companies like Apple, Yahoo and Google, Hulu is definitely on its way to make it big.
Sources: ndtv, latimes, mashable, tgdaily, cinemablend, theatlantic
Apple Bid hulu
online-video
Previous articleVodofone does it again!
Next article"Anonymous" Social Media


text:
Donate on Go Fund Me
Tornado Relief Resources
Looking for Volunteers for Softball and T-Ball
Published: Friday, 09 March 2018 20:08
VOLUNTEER POSTING - COORDINATOR: Are you a good organizer? Do you like sports? Do you want to help support this important youth sports program in Trend Arlington? We're looking for an enthusiastic and capable volunteer to help as T-Ball / Softball Program Coordinator. Please email This email address is being protected from spambots. You need JavaScript enabled to view it. if interested.
We're looking for a Program Coordinator to help manage this year's T-Ball / Softball program, which runs from early May to late June, with registration and coordination activity to begin in mid-March.
This is a part-time, short-term position that you can work when it suits your schedule. Members of the TACA Executive Committee are available to assist.
Communicating with previous year's registrants via email
Collect registrations and registration fees, and remit those to TACA
Prepare the purchase of materials and gear, with Coaches
Work with the City of Ottawa to coordinate the use of softball fields
Communicate with parents and coaches about schedules
Help oversee program budget with TACA Executive
Provide periodic reports to TACA on progress of the program
The Coordinator wouldn't be alone in this project. TACA members are available to mentor and assist you!
VOLUNTEER POSTING - COACHES: Do you love Softball and/or T-Ball? Do you have experience leading and instructing youth in sports and / or recreation programs. Are you good at giving high fives and big smiles? We're looking for enthusiastic volunteers to help as Coaches. Please email This email address is being protected from spambots. You need JavaScript enabled to view it. if interested.
We're looking for Coaches to help run this year's T-Ball / Softball program, which runs from early May to late June. This opportunity is also available to high-school students looking for volunteer hours!
This is a part-time, short-term position that follows a set schedule. The T-Ball program (3 – 6 year olds) takes place Monday evenings from 6pm – 7pm. The Softball program (7 – 14 year olds) takes place Saturday mornings from 10am – 12pm.
Coaching regular practices
Storing and transporting equipment
Prepare the purchase of materials and gear, with Coordinator
Obtain a Police Background Check (TACA will cover costs)
Former coaches will be available to mentor and assist you to ensure a smooth transition and get the program running.
2017/18 Rink Schedule
NEWS ON TREND ARLINGTON RINK!
Please note that the Trend Arlington rink is not yet officially open for public skating. We will notify the community as soon as the ice surface is ready and safe for public use.
This year's scheduled hours for supervised public skating are as follows:
Monday - Friday: 5pm - 9pm
Saturdays: 1pm - 9pm
Sundays: the main rink is open to the public 1pm - 8pm (a private group will use rink from 8pm - 9pm); the puddle rink is open to the public 1pm - 9pm
Canada 150 Community BBQ & Fireworks
Published: Friday, 30 June 2017 11:00
On Sunday July 2, come join us at our community BBQ celebrating our great nation's birthday! Yes, our party is a tiny bit belated. Consider this the after-party to keep the fun going!
Join your friends and neighbours at the Trend Arlington Community Association (50 Bellman Drive) for an evening of music, free food and some dazzling pyrotechnics.
The event will run from 6pm - 10pm. Bring a lawn chair, bring something to drink, and bring a guitar and a song if you're feeling the Canada Day pride! We'll have a BBQ, a campfire, some music, and when it gets dark...FIREWORKS!!!
Trend Arlington Community Garage Sale
Come one, come all! The neighbourhood is holding our annual Community Garage Sale on May 13th from 8AM - 12PM. Residents from across the neighbourhood are encouraged to host their own yard/driveway/garage sale, and of course to visit everyone else's sales, too!
We also expect a lot of traffic from outside the neighbourhood, and some people come as early as possible, so let's get ready!
If you have any questions, please contact the Trend Arlington Community Association president Sean Devine by emailing This email address is being protected from spambots. You need JavaScript enabled to view it.
Announcing TACA\'s New Executive
Published: Friday, 02 December 2016 21:52
The Trend Arlington Community Association is pleased to report that we had a successful Annual General Meeting on Tuesday November 29. There was a solid turnout of members from the community, who helped participate in the official business at hand, but heard several distinct and heart-warming perspectives on what an amazing community we're fortunate to be a part of.
We would like to extend our deepest gratitude to outgoing directors Alison Harvey, Manuel Cruz, Caroline Crowe, and Stewart Kronberg for their long and dedicated service as members of the TACA Executive.
The members on hand nominated and appointed the following new leadership team for the Trend Arlington Community Association: Sean Devine (President), Mark Nyvlt (Vice-President), Julia Addison (Treasurer), Cristian Lambiri (Secretary), Heather Millar (Director-at-Large / Building Manager), and James O'Grady (Immediate Past President).
The new TACA Executive looks forward to continuing the history of service and engagement with our community.
Notice of Annual General Meeting
Published: Monday, 07 November 2016 19:34
Trend Arlington residents are invited to join us on Tuesday, November 29th for the Trend Arlington Community Association's 2016 Annual General Meeting.
This year's theme is "Trend Arlington: The First 45 years". We want to invite community members to share memories and stories of living and raising families in Trend Arlington over the past few decades. Residents are encouraged to share photos, videos, film clips, or anything you think local residents might enjoy. We expect it to be a memorable evening with lots of laughs. If you have a story you'd like to share please contact outgoing TACA President James O'Grady at This email address is being protected from spambots. You need JavaScript enabled to view it..
The meeting will be at 7:00pm at the Community Building at 50 Bellman. At this meeting we will briefly review TACA's finances, elect a new TACA Executive, as well as extend our gratitude to departing members of the Executive. Refreshments will be served.
Notice of TACA Annual General Meeting
October 25 Community Meeting: School Closures
Published: Saturday, 22 October 2016 11:05
The Trend Arlington Community Association (TACA) is hosting a community meeting to have a public discussion and seek input from community members on the proposed OCDSB school closures which will affect several schools in our neighbourhood, including the proposed closure of Greenbank Middle School.
The meeting will be held on Tuesday October 25th at 7:00pm, at the TACA Community Building, located at 50 Bellman. This meeting will be to prepare our community for the separate Public Meeting being hosted by the OCDSB on Thursday October 27th at 7:00pm, at Sir Robert Borden High School. For more info on the OCDSB meeting, please click here.
All members of the Trend Arlington community are welcome to the October 25th TACA meeting. This includes parents of school-age children, students, and community members who don't or no longer have children in the school system. The proposed school closures will have a significant impact on our community as a whole, and we wish to get widespread feedback and discussion on these important matters.
There is no need to RSVP, and we hope to see you there.
Public Consultation: School Closures
Published: Thursday, 06 October 2016 14:45
We're writing today to provide information about important consultations taking place, which have significant bearing on our community. Each of these consultations are open to the public, and we want to have many people from our neighborhood contributing to the discussion as possible.
These consultations involve school closures and re-locations, as well as the location of the new hospital site. We invite you to take a few minutes to read about it in this email, and then to get involved. We've provided you with links and info below.
SCHOOL CLOSURES & RE-LOCATIONS
The Ottawa-Carleton District School Board (OCDSB) is proposing a number of school closures and re-locations, with some scenarios that would impact schools within our community. This is a critical matter that will have an impact on students, families, and our neighbourhoods, and so we hope that as many stakeholders as possible get involved.
The OCDSB has launched a multi-phase consultation process, including an Online Community Engagement & Discussion, as well as a Public Meetings. Parents, students, and other stakeholders are invited to participate in both.
The Online Community Engagement & Discussion phase consists of three stages: the Share stage, the Star stage, and the Discover stage. The Sharestage, in which participants are asked to answer three open-ended questions, ends October 9.
Please take a moment to register and participate in the first stage as soon as possible. Click here and then click the blue "Share Your Thoughts" button to register for online participation.
The Public Meetings phase will include one meeting for our district. The Western Area Public Meeting will take place on October 27, from 7:00pm - 9:00pm, at Sir Robert Borden High School. The meeting is open to all who are interested. For more information click here.
It's more than a community building.
It's about building community.
TACA AGM 2015 - Dec. 1st, 7 - 9:30 pm
Published: Friday, 27 November 2015 15:13
TACA's Annual General Meeeting is taking place this coming Tuesday, December 1st, from 7 - 9:30 pm.
We are focusing on three things this year:
A contest to rename the north-west side of Trend-Arlington Park
A Tree Forum to discuss the condition of our community trees with experts from the City, Eastern Ontario Arborists and Ferguson's Tree Farm in Kemptville
Review TACA CONSTITUTION (draft)
More information about each of these events can found below or by clicking on the appropriate links. If you are interested in joining the TACA Executive, please contact James O'Grady at: This email address is being protected from spambots. You need JavaScript enabled to view it. or (613) 883-7386.
AGM Agenda
6-7 pm - Doors open, Mark Nyvlt on guitar (snacks and beverages will be provided)
7 - 7:10 pm - Councillor Egli briefing
7:10 - 8 pm - Tree Forum
8 - 8:30 pm - Park Re-Naming contest
8:30 - 8:45 pm - BREAK
8:45 - 9:30 pm - AGM Business (Constitution ratification; Executive elections)
Contest to Re-name North-West Side of Trend-Arlington Park
The Trend-Arlington Community Association is holding a contest to re-name the north-west side of Trend-Arlington Park, formerly known as Trend Village Park or Space Park. Today, both Arlington Woods park and Trend Village park are designated as one park on the map, but originally they were two separate parks. With no physical connection between them, they serviced residents with different needs in our community.
TACA would like to return to the original intention of these parks and is asking for your help to select an appropriate name. To participate, please visit: http://www.trendarlington.ca/index.php/blog/134-space-park-contest
Tree Forum: A discussion with the City and tree experts
To build upon the progress we made in the spring with regard to protecting Arlington Woods from corner lot divisions, TACA has invited the City of Ottawa Forestry Department to come speak to us about what's going on with trees in our neighbourhood. Since we've lost a lot of white pines over the last few years and because the Emerald Ash Borer beetle has killed all of our ash trees, we thought this would be a good time to host a tree forum.
In addition to the City, we have invited a local arborist to talk about tree care, as well as a representative from the Ferguson Tree Nursery in Kemptville to talk to us about growing and planting trees from seed. With the help of our residents, TACA would like to undertake a private tree growing and planting initiative to help strengthen the white pine forest in Arlington Woods.
Interestingly, Arlington Woods was developed in 1970 out of an old growth white pine and beech tree forest that dates back to the great fire of 1870, which destroyed a great deal of Eastern Ontario, including 90% of Bells Corners.
As it happens, the City of Ottawa and Tree Ottawa have engaged in an initiative to plant 1 Million trees in the Nation's Capital in time for Canada's 150th Anniversary in 2017. Therefore, this is an excellent time to explore all of our options to improve the health of the trees and forest in our community.
Renewing TACA's Constitution
Its been awhile since TACA updated its constitution. Our old constitution was typed up on legal size paper at least 30 years ago. The copy we have isn't even dated! So, we have undertaken to bring TACA's constitution up to date and to make some important changes to help us continue to serve the community to the best of our ability.
We would like your input before its ratification at the AGM. Please see our website for more information: TACA Constitution (changes tracked)
<< DOWNLOAD EVENT FLYER >>
Alert From Greenbank Community Police Centre
NCC Advisory
Installation of Canada Post Community Mailboxes in Trend-Arlington
Trend-Arlington Community Association launches new website
RSS - Click here when you are on a page that you are interested in following


1 Bedroom Manufactured Home was posted on September 24, 2018 at 9:29 pm. This image is posted on the Bedroom category. 1 Bedroom Manufactured Home is tagged with 1 Bedroom Manufactured Home, 1, Bedroom, Manufactured, Home..
man•u•fac•ture (man′yə fak′chər),USA pronunciation n., v., -tured, -tur•ing.
the making of goods or wares by manual labor or by machinery, esp. on a large scale: the manufacture of television sets.
generation: the manufacture of body cells.
product: Plastic is an important manufacture.
to make or produce by hand or machinery, esp. on a large scale.
to work up (material) into form for use: to manufacture cotton.
concoct: to manufacture an account of the incident.
to produce in a mechanical way without inspiration or originality: to manufacture a daily quota of poetry.
1 Bedroom Manufactured Home Set aren't for everybody, but if you've an admiration of the good traces in craft and architecture, you really like modern bedrooms. Currently, you almost certainly do not know how to develop an ideal contemporary room agreement and you might think it is something that the designer stars have the effect of, nevertheless, you can also experience your home for it, with a little purchasing carefully.
the furniture is clear and sharp indesign along with instead, the bed room models are modern and is typically a signature slice that can sometimes work very well with others or survive alone. You need to start yourself, with the mattress, as this is the center of your room gallery display.
Oftentimes, you should think about today's room like creating your room like a gallery collection. The present day bedroom set allows a contemporary art museum to be created by you in your bedroom. Remember, inside the type of modern furniture after the purpose, the items are obviously ready to do their job, however the experience of the museum is available in the truth that they lack the more lavish style ornaments.
Category: Bedroom. Bed Frames Amazon was published on January 7th, 2018 by and tagged as: Bed Frames Amazon, Bed, Frames, Amazon.
Category: Bedroom. Other Names For Bedroom was published on September 23rd, 2018 by and tagged as: Other Names For Bedroom, Other, Names, For, Bedroom.
Category: Bedroom. 3 Bedroom Apartments Irving Tx was published on March 21st, 2018 by and tagged as: 3 Bedroom Apartments Irving Tx, 3, Bedroom, Apartments, Irving, Tx.
Category: Bedroom. Bedroom Vanity White was published on January 15th, 2018 by and tagged as: Bedroom Vanity White, Bedroom, Vanity, White.
Category: Bedroom. Kingsize Bed was published on April 2nd, 2019 by and tagged as: Kingsize Bed, Kingsize, Bed.


The Republican file photoBoston Celtics President Danny Ainge made a $2,500 donation to Republican presidential candidate Mitt Romney.
—Indianapolis Colts quarterback Peyton Manning, $5,000 to Sen. Bob Corker, R-Tenn., and $1,000 to Sen. Richard Lugar, R-Ind.
—Buccaneers center Jeff Faine, $1,000 to Sen. Bill Nelson, D-Fla.
—Washington Wizards and Washington Capitals owner Ted Leonsis, $35,800 to Obama Victory Fund; $2,000 to Rep. Niki Tsongas, D-Mass.; and $2,000 to Rep. John Sarbanes, D-Md.
—NBA commissioner David Stern, $2,500 to Sen. Sherrod Brown, D-Ohio; $5,000 to Rep. Nita Lowey, D-N.Y.; $30,800 to DSCC; and $4,800 to Sen. Bill Nelson, D-Fla.


text:
Your Gut Microbiome + Circadian Rhythms: The Surprising Connection
By Beth Janes Posted 06-22-2018
You probably know that your circadian rhythm is key for maintaining your sleep-wake cycle. But this internal clock does a lot more than tell your body when it's time to start your day in the morning or climb into bed at night.
Circadian rhythms help regulate the function of cells, organs, and systems, including your immune system, appetite, digestion, metabolism, hormones, and much more. They're also a major player in gene expression and, ultimately, they determine whether you stay healthy or feel lousy.
Now experts have uncovered a new piece of the circadian rhythm puzzle: Gut bacteria. Recent research shows that the trillions of intestinal bacteria you play host to (aka, your microbiome) actually have their own circadian rhythms. And those rhythms impact the balance and type of microbes that reside in your GI tract, as well as their activity.
"Everything on earth has some rhythm," says Dr. Bill Rawls, M.D., Medical Director of Vital Plan. "So it makes sense that even microbes would have resting and active phases." And, as it turns out, those oscillations in your microbiome's circadian rhythm affect your main body clock, and vice versa — your rhythms as the host can also impact those of your gut bacteria.
This two-way street means that if you mess with one, the other can get thrown out of whack, too. That could have far-reaching implications. After all, your microbiome is responsible for roughly 70 percent of immune function, and it's integral in so many other processes, Dr. Rawls says.
What Happens When Your Microbiome Body Clock is Thrown Off
Unlike your body's circadian rhythm, which relies on light/dark cues to maintain a roughly 24-hour cycle, gut microbes aren't exposed to light. Instead, new research suggests they rely on three main factors to regulate their rhythms:
What you eat
When you eat
Your circadian rhythm, particularly your sleep-wake cycle
When any of these factors are off enough to disturb your gut bacteria's circadian rhythms, it can have significant ramifications on your well-being. Take diet, for instance. Researchers found that eating a high-fat diet akin to a modern Western-type one interfered with the circadian rhythms of gut bacteria in mice, causing a decrease in the number of a key type of bacteria and a drop in the production of short-chain fatty acids in the intestines.
That's bad news, considering the fatty acids are known for their anti-inflammatory activity, plus they help bolster intestinal barrier function, keeping pathogens and toxins from leaking across the gut-blood barrier (known as leaky gut). Unsurprisingly, the mice on a high-fat diet showed signs of an overly permeable gut and toxins in their blood, both of which have been linked to inflammation.
A compromised gut barrier, toxins in the blood, and resulting inflammation have also been linked to metabolic syndrome and obesity. The same goes for low fatty acid production in the gut. Normally, these fatty acids help gut bacteria communicate with your brain and liver in ways that may help regulate appetite and metabolism.
But when mice ate fatty, late-night meals—which again, threw off their gut's rhythms—they became obese and showed other signs of metabolic syndrome. The good news is that restricting when the mice ate their fatty food (normal waking times versus, say, midnight) seemed to moderate the effects.
Even more compelling evidence of the role of microbes' circadian rhythms in our health comes from a team of researchers in Israel and their findings, published in the journal Cell. When they transplanted intestinal microbes from people with jet lag — which is known to disrupt the body's and the gut's internal clocks — into mice raised without any gut bacteria, the mice became glucose intolerant and obese. On the other hand, mice given microbes from non-travelers with a normal sleep-wake cycle stayed healthy.
This is only a small sampling of the growing body of research, and more is needed to paint the full picture. But it's clear that respecting the circadian rhythms of both your body and your microbes may be a key component to health.
7 Ways to Reset Your Microbes' Circadian Rhythms
In good news, the same methods you'd take to help restore balance to your gut microbiome are the ones that help keep your gut microbes' rhythms on an even keel, too, says Dr. Rawls. Here are the seven steps he recommends:
1. Stick to a mostly plant-based diet
"When it comes to eating habits, the advice is almost always the same," Dr. Rawls says: Move away from the typical high-fat Western diet — which was shown to interfere with gut bacteria's circadian rhythms — and aim for one that's composed of mainly vegetables, fruit and other plants, plus some lean protein, fewer grains, and less animal fat. "This is more like the diet humans have been eating for about 200,000 years, minus the last 100 years, and it's the diet that best cultivates a healthy microbiome."
2. Avoid eating late at night or irregular eating patterns
The research is mixed on just how bad late-night eating may be and why, but evidence does seem to suggest it's best to close your kitchen at least two hours before bedtime. Along with the science on jet-lagged transplanted microbes, a recent study found that eating close to bedtime or when your body wants you to be sleeping can indeed alter your circadian rhythms, which can in turn influence your microbes' circadian rhythms.
3. Support your gut's lining and microbiome with herbs
"Normalizing herbs help balance your whole system," Dr. Rawls says. Slippery elm bark in particular helps maintain the lining of the GI tract, while berberine and andrographis promote healthy gut flora and support your immune system. Dandelion root also helps soothe the digestive system. Adaptogens like ashwaganda are another way to support a healthy balance of bacteria in your gut, he says. Supporting a balanced and healthy microbiome helps maintain the microbes' normal rhythms, while a strong gut barrier helps protect your system.
4. Maintain a consistent 8-hour sleep schedule — even on Saturday
You can't always avoid jet lag, but you can sidestep another, more common disruptor of the body's circadian rhythms: What scientists sometimes refer to as "social jet lag" — shifting your sleep schedule on certain days for lifestyle reasons.
Regularly having days each week when you stay up later or sleep in longer (weekends, anyone?), and/or days when you wake up much earlier than usual can make it hard for your body and gut to maintain a normal balance of rhythms. So try to go to bed and wake up around the same time every day. And be sure to give yourself enough time to sleep: "There's good evidence we all need eight hours of sleep a night to be healthy," Dr. Rawls says.
5. Unplug at night
Avoid your computer, cell phone, and TV in the hours leading up to bed — their blue light can trick your body into thinking it's daytime, which interferes with the cascade of hormones and chemicals needed to fall asleep and have a good night's rest, Dr. Rawls says.
6. Move more
Staying active helps support healthy sleep and, in turn, maintain your circadian rhythms and that of your gut microbiome. But it's about more than simply going to the gym for an hour or hitting the running trail for a weekly 5K. "We all need to be more active throughout the day, every day," Dr. Rawls says.
Why? "When you don't move for eight straight hours during the workday, your body doesn't make as much nitric oxide," Dr. Rawls explains. That then disrupts the normal production of adenosine, a neurotransmitter that's key for what's called "sleep pressure" — an unconscious biological response that makes you feel sleepy and drift off at bedtime. So, along with bouts of more intense and intentional exercise, be sure to also take regular movement breaks if you have a desk job or tend to sit for long periods.
7. Limit alcohol intake
Alcohol consumption on its own can disrupt your body's circadian rhythms, but it may make the effects of a high-fat diet or unpredictable sleep habits on your microbiome even worse. Studies link alcohol to an increase in inflammatory bacteria and a decrease in bacteria that produce anti-inflammatory chemicals.
More and more, experts are pointing to the microbiome's key role in overall physical and mental health. Take simple steps to balance yours, and not only will you help maintain its circadian rhythm, but you'll also help support healthy immune, digestive, and cardiovascular function, and so much more.
Looking for More Wellness Tips?
Join our newsletter for bi-weekly tools, education, and savings to boost your health.
1. R.M. Voigt, C.B. Forsyth, et. al. Circadian Rhythm and the Gut Microbiome. International Review of Neurobiology, Volume 131, Chapter 9, pp 193-205
2. Leone, V., Gibbons, S. M., et al. (2015). Effects of diurnal variation of gut microbes and highfat feeding on host circadian clock function and metabolism. Cell Host & Microbe, 17(5),
3. Thaiss, C. A., Zeevi, D., et al. (2014). Transkingdom control of microbiota diurnal oscillations
promotes metabolic homeostasis. Cell, 159(3), 514–529.
4. Deaver, J.A., et. al. Circadian Disruption Changes Gut Microbiome Taxa and Functional Gene Composition. Frontiers in Microbiology April 2018, volume 9.
5. Summa, K. C., Voigt, R. M., et al. (2013). Disruption of the circadian clock in mice increases
intestinal permeability and promotes alcohol-induced hepatic pathology and inflammation.
PLoS One, 8(6), e67102.
6. Forsyth, C. B., Voigt, R. M., et al. (2015). Circadian rhythms, alcohol and gut interactions.
Alcohol, 49(4), 389–398.
7. Swanson, G. R., Gorenz, A., et al. (2015). Decreased melatonin secretion is associated with
increased intestinal permeability and marker of endotoxemia in alcoholics. American Journal
of Physiology. Gastrointestinal and Liver Physiology, 308(12), G1004–G1011.
8. Acosta-Rodríguez, V.A., de Groot, M.H.M. et. al. "Mice under Caloric Restriction Self-Impose a Temporal Restriction of Food Intake as Revealed by an Automated Feeder System." Cell Metabolism, 2017; 26 (1): 267
About the Medical Director
Dr. Bill Rawls
How to Prevent 6 Gut Issues That Get Worse with Age "Listen to your gut" has always been sound advice when it comes to making decisions. But it's also smart to take that advice literally — to pay attention to the… Should You Worry About Lectins, Gluten + Other Antinutrients? The term antinutrient sounds ominous, even scary — something you'd be smart to keep out of your diet. But the full story behind these compounds isn't so cut and dry,… The Impressive Health Benefits of Bitter Foods Quick question: What's your favorite food? If you thought of something sweet or starchy or high in fat—or maybe even all three—that's no accident. In fact, it's what you're wired…


The Berkhamsted & Hemel Hempstead Hockey Club ladies' first team had a comfortable 3-0 win against Welwyn as they narrowed the gap on second placed Leighton Buzzard.
Next weekend sees a clash between second and third – a key match that could define whether Berkhamsted are promoted this season.
Elsewhere, the ladies' 2s had a solid 2-0 win against Broxbourne on Saturday, while the ladies' third XI recorded a gutsy 3-2 win against Welwyn.
The youngsters in the ladies' fourth team had a tough game against the adult Chiltern third team as they suffered an 8-1 loss.
However, the men's 4s are enjoying an excellent run of results in 2016 which continued with a 2-1 victory against Cheshunt. Man of the match was Dawood Iqbal with his two goals from short corners.
The men's 3s had a great game against Blueharts – just one point separates the two sides in the league and so it was no surprise when the game ended as a 2-2 draw.
The men's second team have been on a bit of a resurgence recently, however their game against Broxbourne 1s – one of the league leaders – was a game too far. It was 3-3 with 15 minutes to go, but the extra fitness of the opposition led to them winning the game 6-3. Man of the match for Berko was Ollie Bowman.
The men's first XI came up against high flying Blueharts and, in a narrow game, only lost 2-0; demonstrating how close the 1s are coming to being competitive in this tough league.
The Men's 5s started strongly against Hertford but could not keep the pressure up as they were eventually beaten 4-1.


Pro-inflammatory cytokines and bone morphogenetic proteins are generally studied separately and considered to be elements of different worlds, immunology and developmental biology. Varas and colleagues report that these factors show cross-talk in rheumatoid arthritis synoviocytes. They show that pro-inflammatory cytokines not only stimulate the production of bone morphogenetic proteins but that these endogenously produced bone morphogenetic proteins interfere with the effects of pro-inflammatory cytokines on synoviocytes.
Varas and colleagues report in this volume that pro-inflammatory cytokines stimulate the production of bone morphogenetic proteins and that endogenously produced bone morphogenetic proteins interfere with the effects of pro-inflammatory cytokines on synoviocytes . Both tumor necrosis factor (TNF)-α and interleukin (IL)-17 are hallmark cytokines with a dominant function in the immunology of rheumatoid arthritis (RA) [2, 3]. Targeting TNF-α is the prevailing biological therapy to treat RA patients, while targeting IL-17 could be a valuable addition for the management of a subgroup of patients . Both TNF-α and IL-17 are factors that exemplify the dominant role of aberrant immune function in RA.
Bone morphogenetic proteins (BMPs), alternatively called body morphogenetic proteins, are ligands of the transforming growth factor (TGF)-β superfamily, which are central in embryology and developmental biology . Ligands of this family determine cell and tissue fate from early embryogenesis to the formation of complex organs such heart, kidney and others [6, 7].
A few studies have addressed interactions between TNF-α/IL-17 and the BMPs. Expression of BMPs and regulation of their expression by pro-inflammatory cytokines has been shown in RA synovial tissue . The expression of BMP-2 is enhanced by TNF-α in osteoarthritic chondrocytes and pro-inflammatory T-cell cytokines have been suggested to play a role in the differentiation of mesenchymal stromal cells into the osteoblast phenotype and in BMP-induced heterotopic ossification [9, 10]. These studies have focused on the induction of BMP expression by T-cell cytokines but have not investigated whether BMPs have a regulatory effect on T-cell cytokine function.
In a study published in this volume of Arthritis Research & Therapy, Varas and co-workers  investigated the modulatory role of BMPs on TNF-α and IL-17 responses in RA synoviocytes. What emerges from their study is that pro-inflammatory cytokines and BMP pathways interact. BMP receptors are expressed on RA synoviocytes, with ACTRIA/ALK2 and BMPRIA/ALK3 being the most abundant type I receptors while BMPRII was the most easily detectable type II receptor. In addition, BMP ligands, mainly BMP2, and both extracellular and intracellular BMP inhibitors were also expressed by RA synoviocytes. As shown by others, expression of BMP ligands was increased by IL-17 and TNF-α, showing an additive effect on BMP2, 6 and 7 expression. Interestingly, expression of the intracellular antagonists BAMBI and Smad7 was also enhanced by TNF-α/IL-17. However, Smad7 is generally not considered a genuine BMP signaling inhibitor but a blocker of TGF-β signaling.
The most appealing finding is that BMP ligands, produced by autocrine pathways, interfere with the effects of pro-inflammatory cytokines on RA synoviocytes. Blocking signaling of endogenously produced BMP ligands by DMH1, a specific BMP antagonist that inhibits signaling through ALK1, ALK2, and ALK3, enhanced both the mRNA and protein expression of IL-8 and granulocyte macrophage-colony stimulating factor, indicating that BMP ligands block the TNF-α/IL-17-induced production of these cytokines. Moreover, the expression of IL-17-induced CCL-2 and TNF-α/IL-17-induced matrix metalloproteinase (MMP)2 and MMP3 expression was further enhanced by inhibition of BMP signaling. Vice versa, addition of exogenous BMP6 inhibited the TNF-α/IL-17-induced elevated expression of these proteins.
This study shows that the presence of an endogenous BMP signaling pathway in RA synoviocytes meddles with the effects of pro-inflammatory cytokines on these cells. Since it can be anticipated that synoviocytes are exposed to TNF-α/IL-17 in a joint with active RA, activation of the BMP pathway might dampen the effects of these pro-inflammatory cytokines. Furthermore, the authors hypothesize that BMP signaling could have an anti-inflammatory role in the control and maintenance of low levels of pro-inflammatory factors in healthy joints or the early stage of RA. In this way BMPs have a disease-controlling action. In contrast, BMPs upregulate their own antagonists, primarily BAMBI and Smad7. In the case of Smad7 it can be anticipated that mainly TGF-β signaling via the Smad2/3-Smad4 route is blocked. Due to the potent and extensive, chiefly anti-inflammatory, action of TGF-β, one would expect that BMP-related induction of Smad7 will limit the anti-inflammatory action of TGF-β. In this way induction of BMP and TGF-β inhibitors could contribute to the chronic inflammation seen in RA. What is more, the use of BMPs as an anti-inflammatory route does not seem to be an attractive option to follow due to the upregulation of BMP and TGF-β signaling inhibitors that will interfere with the potential anti-inflammatory action of these ligands.
A limitation of the study by Varas and colleagues is that synoviocytes between passages 4 and 9 were used. Although it is known that RA synoviocytes keep their phenotype in vitro, it cannot be excluded that the role of BMP signaling is altered during culture on plastic. Moreover, data are not provided that show whether differences exist between different patient (subgroups) nor what the effect of medication is. However, due to the late passage in which cells are studied, the influence of medication can largely be ruled out.
The major value of this paper is that it shows that BMP and inflammatory pathways interact. Although these pathways, and factors involved, are in many cases studied separately, Mother Nature is not confined to man-made boxes. More and more it becomes clear that human physiology is an holistic system in which the same factors are used over and over and which shows interference on all levels. The paper of Varas and colleagues clearly shows that inflammation and tissue development and maintenance are not separate systems but instead are integrated.
See related research by Varas et al., http://www.arthritis-research.com/content/17/1/192.
PMvdK and ENBD are supported by the National Reumafonds.


text:
Loading...

Projects

    New Project
    <alerts alerts="alerts"></alerts>

            {{(project | displayName) || project.metadata.name}}

            <truncate-long-text content="project | description" limit="512" use-word-boundary="true"></truncate-long-text>

          <button class="btn btn-danger"
                  type="button"
                  ng-click="$event.stopPropagation(); deleteProject(project);"
                  style="margin-right:10px; color: #fff !important;">
            Delete
          </button>
          <button class="btn"
                  type="button"
                  ng-click="$event.stopPropagation(); toggleConfirm(project);"
                  style="color: #fff !important;">
            Cancel
          </button>

      A cluster admin can create a project for you by running the command
        oadm new-project <projectname> --admin={{user.metadata.name || '<YourUsername>'}}

      A project admin can add you as an admin to a project by running the command
      oc policy add-role-to-user admin {{user.metadata.name || '<YourUsername>'}} -n <projectname>

Welcome to OpenShift.

    OpenShift helps you quickly develop, host, and scale applications.

    Create a project for your application.

  New Project

To learn more, visit the OpenShift documentation.

    A cluster admin can create a project for you by running the command

      oadm new-project <projectname> --admin={{user.metadata.name || '<YourUsername>'}}

redpajama_set_name: RedPajamaGithub


Bathroom design Tiles for bathrooms Classic. Bathrooms. Master.
•Authorities have manufactured types for unique forms of bathroom for presenting selections to buyers.
•You will make collection out of such types of have your private types.
•New types will be manufactured by doing some improvements to older types.
•You will work with tiles with your bathroom in an effort to contain a pleasant look.
•You can use bathroom tile ideas and install desired types of tiles in your bathrooms.
Tiles of unique types are out there which will be made use of down to demands. There are tiles of unique types and patterns which are manufactured for bathrooms. You will contain exclusive tiles which are manufactured for bathrooms. There are normal tiles which are acceptable for lots of requirements including bathrooms. You contain lots of selections in doing collection of tiles which might raise magnificence connected with your bathrooms.
Cleaning products for bathrooms are out there in them to make sure that buyers will work with them and hold the bathrooms sparkling. Taps are out there with bathrooms to make sure that buyers will work with them and receive water at any time period. There are lots of models with taps which are manufactured for bathrooms. You will contain them with your bathroom and work with them for an extensive phase. With the help of bathroom tile ideas you can get tiles which will increase beauty with style.
Bathrooms contain supply of wintry and popular water to benefit buyers. Pots of unique types are manufactured indoors bathrooms to be certain that buyers will remain reliable from complications. Lots of new factors are manufactured by corporations all the time which will be made use of indoors a bathroom.
Tags: cool. classic. picture. amazing. tile. modern.


+2 for acc trading, its time... wouldn't ya say!
all u ppl thinking account trading should be put in place are playing the wrong game... and all i can say to u is you are NOOBS.
I am waiting for a public test server.Good job!
And what about new talents I have 67 free, they are wasting help me free them!
Seems like we have a retard player, how do you avoid account trading what will it disurb you for?
I hope you guys keep working on this little updates till we have a lot of new stuff to make the normal gameplay better and more enjoyable.
I'm looking forward to the public test server!