In 2005, EDC and EDC Finance Corporation welcomed Lyle Hosler as Project Manager. Lyle now serves as Director of Finance and is responsible for overseeing EDC Finance Corporation's loan activity for business and agricultural enterprises.
Before joining EDC, Lyle held finance positions at Fidelity Investments and Fulton Bank. A graduate of Susquehanna University with a B.S. degree in Business Administration, Lyle completed his graduate studies with an MBA from Penn State University.
In 2012, EDC Finance Corporation welcomed Randy Johnston as Economic Development Loan Officer. In this position, Randy fosters community economic development opportunities; structures finance packages through various state and federal programs; and partners with local organizations to assist business and agricultural enterprises primarily in Lancaster, but also in surrounding counties.
Randy brings over 30 years of commercial banking experience to EDC Finance Corporation and has served as a senior commercial relationship manager at a several local financial institutions. Randy earned a B.S. degree in Business Administration from Miami University, Oxford, Ohio.
In 2014, Leigh Bardell joined EDC Finance Corporation as Finance Project Manager where she works closely with EDC Finance loan officers to assemble, analyze, and underwrite EDC Finance's diverse base of economic development loan projects. Leigh is also responsible for managing EDC Finance Corporation's loan application material.
Leigh has over 15 years of commercial banking experience, most recently with PNC Bank. She received her Associates Degree in Accounting from Harrisburg Area Community College.
Prior to joining EDC, Jean attended Millersville University and was employed in the personnel field.
In 2017, EDC Finance welcomed Amanda Mosso as Operations/Administrative Officer where she provides key administrative support for accounting functions. In addition, she assists in areas of economic development and the lending process.
Amanda earned a B.A. in Business and Art from Juniata College and captained the Juniata field hockey team. She actively continues to participate in the sport by coaching for Lanco Premier Field Hockey Club. In her free time she enjoys yoga, gardening, reading and spending time with family.
In 2015, EDC Finance welcomed Jessica Hamilton as Funding & Servicing Officer where she coordinates loan closings and handles loan servicing requests from existing borrowers. Jessica also works with Next Generation Farmer loan projects in Lancaster County.
Jessica has over 10 years of commercial banking experience, particularly in the areas of loan settlements and asset recovery, most recently with Metro Bank. She received her Associates Degree from Harrisburg Area Community College.


This issue of the IJW presents news about the 6th World Wilderness Congress, 18-25 October 1997 in India. John Hendee (managing editor) offers insight into this upcoming event – the first WWC to meet in a developing nation. A quiz by Kendall Clark and Susan Kozacek can tell you how your personal wilderness values rate, is fun and also proves extremely useful in wilderness management training sessions. Aaron R. Kelson and Robert J. Lilieholm present a scientific study of how activities on adjacent lands influence wilderness resources.
A very personal note from WILD's President Vance Martin, remembering Sir Laurens van der Post closes this issue of the IJW. Vance retells when he first read "Heart of the Hunter," and the mesmerizing way in which van der Post was able to capture in a story the "sense and texture of wilderness." Vance continues on to tell of when he first met van der Post, at the 2nd World Wilderness Congress (Australia 1980), and lead to a 20 year working and learning relationship.
Mamphela Ramhele provides a study of how wilderness in used for healing in South Africa, with an emphasis on WILD's partner organization The Wilderness Leadership School. He writes, "From time immemorial, the wilderness has been associated with the search for meaning and the need for restoration of interior balance…" This issue includes three great book reviews for "Guardians of the Parks, A History of the National Parks and Conservation Association," by John C. Miles, "Wild Ideas" by David Rothenberg (ed), and "Troubled Waters: The Fights for the Boundary Waters Canoe Area Wilderness," by Kevin Proescholdt.
Roderick Nash, author of "Wilderness and the American Mind," contributed an article for this IJW, on the implications of the internet on the soul of wilderness. Stating an case much before it was mainstream, Nash encourages readers to step away from technology to experience wilderness. Greg Aplet and Jerry Greenberg provide a written history of The Wilderness Society (US), and an insight into new and changing goals for the organization.
The inaugural issue of the IJW announces the 6th World Wilderness Congress (Bangalore, India 1997), and an editorial welcome by John C. Hendee, the managing editor of the Journal. He states the vision of the journal as "an international voice integrating the wilderness and wild-land concerns of scientists, planner, managers, educators and citizen environmentalists, worldwide." This issue also includes an article by Dr. Ian Player, founder of WILD, in which he tells the story of his friend and mentor Magqubu Ntombela's words that prompted Ian to start the World Wilderness Congress and the organizations that now form The Wilderness Network.


Yesterday was Labor Day, which means today is something of a holiday itself. It's the time when you're supposed to collect all of the white items in your closet and banish them to storage for the next two seasons. Or so says a century olds fashion dictate that has somehow loomed large in the public's conscious despite the fact that the actual fashion industry has ignored it for decades if not more.
The types that love to tell you what to wear take greater pleasure these days in explaining exactly how to wear white after labor day rather than tell you not to. No one blinks when an actress is decked out in a couture white gown to pick up an Oscar statuette months after Labor Day has come and gone (as Jennifer Lawrence did in 2014). Whites dot the Fall collections of even the most proper legacy fashion houses, and, as the most frequent retort to the rule points out, Coco Chanel herself famously wore white year-round.
The "no white after Labor Day" adage has moved on from actual rule to something of a punchline (with either fashion or proper stuffy types often meant as the target). It is an undying meme. In fact, over the weekend satirist of the moment, John Oliver, sank his teeth into the rule and suggested seemingly frivolous rules to go along with other holidays.
"Honestly, we should be using more holidays as arbitrary points to stop doing things," quipped the comic. "For instance, we should have a rule that after Thanksgiven you should stop decorating your home with Gords. Its cute in October, it's acceptable but obnoxiously folksy in November, but after that, you're just keeping loose produce lying around."
It's popped up elsewhere as a punchline before.
On Fraiser, the uptight and proper character of Niles Crane once said that his idea of true love involved "sharing a laugh together when you see someone wearing white after Labor Day."
S. Epatha Merkerson's character om Law and Order once wanted to "add a charge of felony bad taste" to the wrap sheet of suspects dressed in white during the chilly month.
Notable cinematic fashion victim Josie Grose of Never Been Kissed wore white after Labor Day, only to have the look stained in an embarrassing cafeteria fiasco.
It is also, apparently, one of the most memorable punchlines in the 2005 Dukes of Hazzard Movie (though, we imagine it didn't have much competition).
Perhaps the most memorable "no white after Labor Day" moment in pop culture comes towards the end of John Waters' Serial Mom. Kathleen Turner's murderous housewife ruthlessly kills people over all matters of social faux pas (including, we suspect revealing spoilers without proper warning, so consider this yours), and caps off her spree by bludgeoning a woman for the crime of wearing white in the FAll.
As it turns out, Waters himself is actually a remaining devotee of the rule.
The meme, of course, is now even a literal meme.
It's easy to imagine why the rule has such staying power as a punchline. Both fashion and high scoiety manners seem to many to be full of frivilous rules (and in fashion's case, they change all the time). "No white after Labor Day" has become the most well known, and the quickest to pull to mind when someone wants to skewer them all. So while banishment of white after the start of Fall may no longer be a practice many actually follow, jokes about the rule will probably remain a fashion for a long while.


text:
The core of rebel8
Deeply rooted in graffiti, skateboard, and tattoo culture, REBEL8's core purpose is to showcase their trademark lifestyle through unique products.
Now in it's 11th year and internationally recognizable, REBEL8 is still committed to the communities from which it hails.
Joshy D.
REBEL8 founder Joshy D. met Mike Giant in the late 1990's in San Francisco's then bustling graffiti scene. Joshy ran the popular graffiti website, HiFiArt, and Giant was one of the city's most notorious writers. Years later, after an organic friendship developed between the two, Joshy approached Giant about creating a handful of t-shirt graphics. In 2003, with just $500, Joshy printed a small run of tees and sold them out of a messenger bag around the city. REBEL8 was born.
REBEL8 is one of the last authentic brands left that incorporate original artistic works within their pieces. Many graphics within the REBEL8 product line are hand illustrated, with no computer generated enhancements or manipulations. The man behind this original artwork at REBEL8 is the legendary tattoo and graffiti artist Mike Giant.
Rebel8 "Los Ochos" M..
Rebel8 "Tilted 8 Logo&quo..
REBEL8 Eighters Snapback Cap

redpajama_set_name: RedPajamaCommonCrawl


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text:
Tonight on the Tube: Friday Night Lights, Veronica Mars, Boston Legal and Game 3 of the World Series
Jason the TVaholic Oct 24, 2006 Tonight on the Tube 0 comments
The first two shows in the Prime Picks are two shows that you should check out if you haven't got a chance yet. Friday Night Lights is a very good family drama and captures small town life in Texas quite well. Even if the idea of a whole town living and dying with every win and loss sounds bizarre to many, don't let that keep you away from this wonderful show. Veronica Mars is another great show that not enough people seem to be watching. The stories and mysteries are always very well down. The viewer can jump in at anytime, as each episode is somewhat self-contained with the mystery of the week. After a couple of episodes under your belt you will get enough of the dynamic and be able to really enjoy the show. If you aren't watching either of these shows then why not? What is keeping you from tuning in? Let us know by leaving a comment.
Friday Night Lights (NBC): New. The team is heading into a game against its biggest rival and Coach Taylor must put together a winning strategy. While some of the team is planning to retaliate against the other school after they strike first during rivalry week. Jason Street is surprised by what he sees at the rehab center and starts to think that maybe he can get better.
Veronica Mars (The CW): New. Logan is told that his inheritance is starting to run low and gets Veronica to look into his finances to see why that might be. Keith is hired by a woman to investigate her husband who may be cheating.
Boston Legal (ABC): New. Coho and the rest of the team try to fix the damage caused by their client's father on the stand.
Gilmore Girls (The CW): New. Something stinks in Stars Hollow and Lorelai shows up to Friday dinner with Christopher to the delight of Richard and Emily.
The Unit (CBS): Repeat. The team is trying to track down some missiles before they are sold on the black market.
Criminal Minds (CBS): Repeat. A group of college students are murder and it looks like it might be a ritual killing of some sort. The team investigates.
Dead Like Me (Sci Fi): Repeat. The second of two episodes has the reapers running around on Halloween taking souls as a serial killer stalks the town.
Eureka (Sci Fi): Repeat. The "Alienated" episode replays.
Nip/Tuck (FX): New. Sean moves up a scheduled surgery based on a secret from his childhood that makes him determined to do it. Runs 64 minutes and plays twice.
The Hungry Detective (Food Network): New. Get a look at some very interesting restaurants around the country.
Rachael Ray's Tasty Travels (Food Network): New. Tonight she lets you in on some of the best pubs around the country.
Road Tasted (Food Network): New. Some Seattle specialties are eaten.
FOX has Game 3 of the 2006 World Series as they move to St. Louis with the series tied one game apiece.
Previous: Tonight on the Tube: Prison Break, Heroes, Studio 60, CSI: Miami and Monday Night Football
Next: New TV on DVD: Best of Saturday TV Funhouse, MacGyver, Wings and More


text:
[NTG-context] new upload / more math
Willi Egger context at boede.nl
Fri Apr 1 22:16:23 CEST 2022
Previous message (by thread): [NTG-context] new upload / more math
Next message (by thread): [NTG-context] mkiv
Hi Hans,
congrats for this new society! — At this date it is specially hilarious :-)
Happy CMS!
> On 1 Apr 2022, at 16:30, jdh via ntg-context <ntg-context at ntg.nl> wrote:
> Wrong.  The imperial measurement system, may give Europeans a headache, but is NOT obsolete, by any means.  A good chunk of the world use the imperial measurment system and may be required in certain books, depending on a country's standards.
> dh
> ---------
> Henning Hraban Ramm via ntg-context <ntg-context at ntg.nl> wrote:
>> Oh, great work, thank you! (While I keep working with WebCMS and avoid
>> math...)
>> And I guess you forgot to mention that you discontinued the support
>> for non-metric measures like the obsolete inch, except Potrzebie, of
>> course.
>> Hraban
>> Am 01.04.22 um 10:02 schrieb Hans Hagen via ntg-context:
>>> Hi,
>>> As most of you know by now, Mikael and I are working on a math
>>> support upgrade. In order to let users keep up we uploaded a new
>>> version. We have been revisioning some of the more obscure
>>> constructs where we have   no clue of usage, like pmod, bmod,
>>> bordermatrix etc, commands that we   took (and reimplemented)
>>> decades ago from plain TeX or AMS TeX, assuming that these are
>>> standards.
>>> In this release, encouraged by the positive response we received
>>> from users regarding the new simplealignment construction, and in
>>> particular regarding the self-explaining sesac, we have decided to
>>> introduced some new constructs. First out is
>>> \startformula
>>> \startxıɹʇɐɯ
>>> \NC a_1 \NC b_1 \NC c_1 \NR
>>> \stopxıɹʇɐɯ
>>> \stopformula
>>> for rotation matrices. This was demanded for some advanced math
>>> courses that Mikael teaches. It might inspire users to come up with
>>> demands that suits their own obscure but nevertheless interesting
>>> math.
>>> At some point we realized that, with (also) scientific publishers
>>> (of math journals) moving to MS Word and Indesign, we operate in a
>>> rather peculiar niche and the fact that we use an upgraded and more
>>> granular math engine, made us wonder how to communicate all these
>>> new features and standards that we set. It is for that reason that
>>> from now on we will operate under the CMS umbrella. That
>>> abbreviation stands for ConTeXt Math Society. It has no funny swirly
>>> TeX logo which itself is a statement: in Unicode math script and
>>> calligraphic alphabets are so messed up that it is impossible to
>>> have a reliable and predictable rendering. We go for Dutch and
>>> Swedish simplicity in the spirit of W.N. Lansburgh: back to the
>>> times before TeX was written (1964). There will be no limits and
>>> boundaries set. (Talking math limits and boundaries: these can
>>> already go everywhere anyway, as can fences.)
>>> So, when we mention CMS, we mean serious math business, but
>>> kindergarten math is also embraced! There are no consequences for
>>> users: ConTeXt users with a proven math track record are
>>> automatically a member, but we are not too picky, everyone is
>>> welcome. We don't have honorary members but Taco (the first ConTeXt
>>> math user) and Aditya (the most experienced   one) might consider
>>> themselves as such. Mikael Sundqvist is the chairman, which is a
>>> livelong appointment. (A nice side effect is that with Arthur living
>>> in Sweden too, that gives us a very strong position in the TeX
>>> landscape there.)
>>> So, today's upload is sort of special: welcome CMS (ConTeXt Math
>>> Shines), goodbye AMS (American Math Second). Of course we're open
>>> for suggestions and it being an open society all voices will be
>>> heard, but only proper (retro) math cf Lansburgh will be honored. Of
>>> course we only listen to ConTeXt users and, as that package is not
>>> supposed to be used for serious math, we don't bother about the few
>>> publishers left that still do math.
>>> Are we done? Not yet. We're in the middle of (colorful and graphic)
>>> alignment ornaments and after that we're going to expand and improve
>>> multi-line display formulas and equation numbering.
>>> It will be no coincidence that the cover of Landburghs book about
>>> math typesetting has a prominent 'AWE' embedded in a logo with a
>>> lion on top: we hope all users are in awe about what the TeX lion
>>> can do.
>>> Mikael S & Hans H
>> ___________________________________________________________________________________
>> If your question is of interest to others as well, please add an entry to the Wiki!
>> maillist : ntg-context at ntg.nl / http://www.ntg.nl/mailman/listinfo/ntg-context
>> webpage  : http://www.pragma-ade.nl / http://context.aanhet.net
>> archive  : https://bitbucket.org/phg/context-mirror/commits/
>> wiki     : http://contextgarden.net
> ___________________________________________________________________________________
> If your question is of interest to others as well, please add an entry to the Wiki!
> maillist : ntg-context at ntg.nl / http://www.ntg.nl/mailman/listinfo/ntg-context
> webpage  : http://www.pragma-ade.nl / http://context.aanhet.net
> archive  : https://bitbucket.org/phg/context-mirror/commits/
> wiki     : http://contextgarden.net
More information about the ntg-context mailing list


One of my favorite things about traveling is simply being able to experience new landscapes. Having always lived on the East Coast of the United States, it is true that the Rocky Mountains are on a completely different level than anything back home. We're just not used to seeing anything that high and the "above tree line" elevations of these mountains make them even more awe-inspiring and sometimes "otherworldly".
I also love observing the different trees and unique weather patterns of a new place. The deciduous forests of the eastern region of the country are beautiful, but the evergreens, aspen groves, and tundra of Colorado are amazing sights. A note on the weather when climbing mountains, there is roughly 3 degrees of temperature drop for every 1000 feet higher you go, which is why spending time in the high mountains is a great way to beat the summer heat!
As much as you may try to prepare, it's likely that you'll experience the effects of altitude if you're visiting a place like the Colorado Rockies for the first time. It can be very difficult to deal with, especially if you get altitude sickness while hiking a higher mountain. However, it's not likely that it will ruin your trip or prevent you from doing any hiking at all (but it is interesting to feel out of breath while simply walking around camp). The only way to get ahead of it is to spend at least a few days and nights at altitude, slowly building up your exposure to higher and higher elevations. The old adage is "Climb high, sleep low." If you do start to feel light-headed, nauseous, or like you're having extreme difficulty breathing while climbing or hiking, descend to lower altitude as quickly as possible; those symptoms generally clear up quickly once you're significantly lower. Even though it can be tricky to get your body used to journeying up into the high mountains, it's almost always worth it and with a little forethought and time you will likely avoid any issues.
There are 70 peaks in the lower 48 states that are considered 14ers (mountains that are at least 14,000 feet high with at least 300 feet of prominence). Fifty-three of those peaks lie inside of the state of Colorado and one of these peaks was our particular focus on this first trip to the Rockies. Mount of the Holy Cross is a non-technical climb, but it is one of the longer and harder mountain hikes at 12 miles of distance and almost 6,000 feet of elevation gain.
Climbing 14ers in summer is the most typical thing to do, unless you're specifically aiming for a snow climb (snow is often in the mix from October through May/June). Because of this it's best to climb 14ers during the week to avoid crowded trails. Fortunately, we had both perfect weather and pretty light traffic on the Monday that we climbed. The hike was grueling and the altitude effects hit hard, but it was a great achievement to bag our first 14,000 foot peak.
While this was my first trip to Colorado and to high elevations, it wasn't my first camping or backpacking trip. That previous experience I had with my gear and with various weather conditions really made the camping aspect of this trip easy and relaxing. It's a great feeling to know that your campsite and tent are all in order and will take care of you at the end of the day when you're exhausted and it's raining. If you're new to camping or backpacking, it can be really helpful to go on a few local trips where the purpose is just to get familiar with all of your gear. It may feel a little lame or like a waste of time, but if you make that effort then when you go on a more epic adventure, you can focus on the amazing place you're visiting, not on how to put your tent together or if your sleeping bag is going to be warm enough.
Know and trust your gear.
Sometimes embracing adventure means taking whatever opportunities come up, because weather, crowded trails, getting lost, or getting altitude sickness can always change things up. While we originally planned this trip to be about summiting 14ers, we ended up with a variety of activities after climbing Mt of the Holy Cross early in our week from taking the jeep up a rocky forest road on a rainy day to visiting the city of Boulder. The state of Colorado is a big and adventure-rich state with tons of variety in things to do, so with a little time to drive around, you should have no problem finding a great place to explore. Even if you have to change up your plans due to unforeseen circumstances, it will add to the story of your trip. Remember that adventure is about being flexible making the most of each day, regardless of what comes!
In need of rest, we opted to drive up Mt Evans - & were rewarded!
Always find a good spot for sunset.


text:
#ifndef itkMetaConverterBase_h
#define itkMetaConverterBase_h

#include "itkSpatialObject.h"
#include "metaObject.h"

namespace itk
{

/** \class MetaConverterBase
 *  \brief Base class for MetaObject<->SpatialObject converters
 *
 *  SpatialObject scenes are written and read using the MetaIO
 *  Library.  This is managed by the MetaSceneConverter class,
 *  which converts MetaObject scenes to SpatialObject scenes and
 *  vice versa.
 *
 *  MetaScene walks the scene and uses the converter on each
 *  object in the scene.
 *
 *  \ingroup ITKSpatialObjects
 */
template <unsigned VDimension = 3>
class ITK_TEMPLATE_EXPORT MetaConverterBase : public Object
{
public:
  /** standard class type alias */
  using Self = MetaConverterBase;
  using Superclass = Object;
  using Pointer = SmartPointer< Self >;
  using ConstPointer = SmartPointer< const Self >;

  /** Run-time type information (and related methods). */
  itkTypeMacro(MetaConverterBase, Object);

  using SpatialObjectType = SpatialObject<VDimension>;
  using SpatialObjectPointer = typename SpatialObjectType::Pointer;
  using MetaObjectType = MetaObject;

  /** Read a MetaIO file, return a SpatialObject */
  virtual SpatialObjectPointer  ReadMeta(const char *name);

  /** Write a MetaIO file based on this SpatialObject */
  virtual bool WriteMeta(const SpatialObjectType *spatialObject, const char *name);

  /** Convert the MetaObject to Spatial Object */
  virtual SpatialObjectPointer MetaObjectToSpatialObject(const MetaObjectType *mo) = 0;

  /** Convert the SpatialObject to MetaObject */
  virtual MetaObjectType *SpatialObjectToMetaObject(const SpatialObjectType *spatialObject) = 0;

  /** Set/Get flag for writing images to separate files in metaImage
   * instances
   */
  void SetWriteImagesInSeparateFile(bool writeImagesInSeparateFile);
  bool GetWriteImagesInSeparateFile();

protected:
  /** Creator for specific metaObject, defined in subclass */
  virtual MetaObjectType *CreateMetaObject() = 0;
  MetaConverterBase() : m_WriteImagesInSeparateFile(false)
    {}

private:
  bool m_WriteImagesInSeparateFile;
};

}

#ifndef ITK_MANUAL_INSTATIATION
  #include "itkMetaConverterBase.hxx"
#endif

#endif // itkMetaConverterBase_h

redpajama_set_name: RedPajamaGithub


text:
Telluride Film Festival 2019: "Waves" Review
Ashley Menzel September 1, 2019
Waves came out of nowhere at Telluride Film Festival and has continued to stun every audience since its premiere. Directed by Trey Edward Shults, Waves follows the turbulent lives of an African American family as their dynamic evolves and changes. Divided into two distinctive halves, the first follows Tyler (Kelvin Harrison Jr.). The only son in the family and all-star athlete, his father, Ronald (Sterling K. Brown) constantly pushes him toward success and hard work to rise above the stereotypes society places on them. As Tyler's life begins to unravel, a grave mistake and accident bring an abrupt halt to his daily life and his family's as well. This is where the second half of the film kicks in as we get to focus on the rest of the family, in particular, his sister, Emily (Taylor Russell). As the family navigates what their lives have become, Taylor must pick up the pieces and let go of her anger. Through her new relationship with Luke (Lucas Hedges), she finds happiness and peace.
The two distinct halves of the film are very different in tone. The first is building tension and high stress throughout. The suspense of the story culminates in a big way and we are left in the wake. Once left with what happened in the first half, we are allowed to breathe in the second half which while lighter, isn't without its emotional heft and scars from the first half. It is more hopeful and more reflective, allowing the audience to feel the emotional trauma of the first half but learning, like the rest of the characters, that life must go on.
Waves is really unlike anything I've seen. Not only are the performances phenomenal but the entire film plays like a masterpiece. Shults uses color and music to enhance the motion and pull of the film without being overbearing. While those moments are somewhat disorienting, they allow for a brief pause to analyze what you've seen and hone in on the sounds and anticipation of what is to come. Shults has made a mark with this film.
Kelvin Harrison Jr. gives yet another powerhouse performance as Tyler. The scenes he shared with Sterling K. Brown are high-strung and pulsating with strain. We see a transformation in him that is both terrifying and in a way, completely relatable. It can't be stressed enough that his toughest scenes to watch are some of the best acting we've seen from a young actor this year. Taylor Russell comes out of the fringes during the second half and we get beautiful scenes filled with joy and love but also with sorrow for the life she's lost.
What is miraculous about the writing of the film is that Shults gives us fully developed characters, not just focusing on the younger cast. We get in-depth characters with the parents played by Sterling K. Brown and Renée Elise Goldsberry. We see the rift in their relationship begin with subtle glances and get a culminating argument that lays out their emotions. They have solid chemistry that feels authentic. Lucas Hedges as Luke continues to bring powerful performances to every role he tackles. He and Taylor embark on a trying journey together and he handles the goofy awkward teens and the heartbreaking young man with ease. He is the epitome of a true artist.
What is phenomenal about Waves is that each individual scene, which can play like tiny vignettes, are perfect illustrations of the genius of the film. Whether it is Emily and Luke laughing and joking about something or the heated argument between Taylor and his girlfriend, Alexis (Alexa Demie), Shults and the wildly talented actors have managed to capture life and human emotion that is very rarely done in such a beautiful way. Waves is undoubtedly a masterpiece and is destined to make a lasting impact on the world of film and storytelling. An Oscar-worthy cast and a beautifully directed film make Waves easily the best film of Telluride 2019 and a big disruptor in the potential Oscar conversation.
Ashley Menzel
Ashley Menzel is an avid film lover and lives in Los Angeles, CA. She loves foreign films and dramas and reading books that have film adaptations. Her favorite movie of all time is One Flew Over the Cuckoo's Nest. She loves Doctor Who, Supernatural, iZombie, and Grimm.
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Telluride Film Festival 2019: "Waves" Review Waves came out of nowhere at Telluride Film Festival and has continued to stun every audience since its premiere. Directed by Trey Edward Shults, Waves follows the turbulent lives of an Africa...
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Cast:Kelvin Harrison Jr., Lucas Hedges, Sterling K. Brown
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Ameisen organisieren Städtereisen und ein computing device spielt Schach – wie es geht, das zeigt dieses Buch. Mit ergänzenden Themen und neuen Codebeispielen wird auch in der vorliegenden Auflage für Programmierer, die bereits erste Erfahrungen gesammelt haben, ein breites Spektrum an Problemlösungsstrategien anhand konkreter und verständlicher Beispiele vorgestellt.
Sie können künftig selbstständig neue Aufgabenstellungen bewältigen, Optimierungspotential in bestehenden Programmen entdecken und damit bessere software program schreiben.
Meant for college students of arithmetic in addition to of engineering, actual technological know-how, economics, enterprise reports, and machine technological know-how, this instruction manual includes very important details and formulation for algebra, geometry, calculus, numerical tools, and information. complete tables of ordinary derivatives and integrals, including the tables of Laplace, Fourier, and Z transforms are incorporated.
This e-book comprises programmatic essays that target broad-ranging proposals for re-envisioning a self-discipline of comparative philosophy of religions. It additionally encompasses a variety of case reviews focussing at the interpretation of specific religio-historical information from relatively orientated philosophical views.
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Nonliving vaccines
Bacterial Vaccines
Viral Vaccines
The DIVA Principle
Soon after Louis Pasteur identified the basic principles of vaccinology, Salmon and Smith demonstrated that killed Salmonella bacteria could serve as an effective vaccine. This simple empirical approach was rapidly adopted, and many diverse killed bacterial vaccines were rapidly developed. For example, killed typhoid vaccines were administered to British soldiers by the end of the nineteenth century. They worked but were somewhat toxic and caused significant morbidity. Today whole-cell killed Bordetella pertussis vaccine is still given to children in many countries to protect against whooping cough because it is cheaper than the less toxic acellular vaccine.
This approach to developing vaccines can be summarized as "isolate, inactivate, and inject." This has worked well and is especially effective in the production of autogenous vaccines (Chapter 18). The great advantages of this type of vaccine are its safety and simplicity—and thus reduced cost.
Technically speaking the term "killed vaccines" applies to the death of living organisms such as bacteria. Likewise, the term "inactivated vaccines" applies to the treatment of molecular constructs such as viruses.
This type of vaccine may contain either a very complex antigenic mixture such as that found in killed whole organisms, or the vaccine components may be purified to various degrees. Unnecessary or toxic components may be removed, but the vaccine may be enriched with those antigens that are directly responsible for the protective immune response. The degree of purification demanded will depend upon the costs of the purification process and any adverse effects mediated by the unwanted/unnecessary components.
The major problem with these nonliving vaccines is that they cannot invade host cells. As a result, they act as exogenous antigens and stimulate type 2 immune responses and antibody formation rather than type 1 cell mediated responses. Therefore they may provide only weak or transient immunity against viruses or intracellular bacteria. In addition, killed vaccines, depending upon their purity and toxicity, may require administration of multiple doses to generate strong prolonged immunity. Each vaccine dose increases the chances of the recipient developing allergic or other adverse reactions. In many cases these killed/inactivated/subunit vaccines also require adjuvants that carry with them the potential to induce innate immune responses resulting in other problems.
Until the 1990s, most veterinary vaccines either contained inactivated/killed organisms that were adjuvanted with alum or oil, or they were modified live vaccines (Table 3.1). Increased knowledge of microbial genetics has revolutionized the way in which vaccine antigens can be generated. These vaccines may now contain cultures of organisms that have been killed by chemical or physical means; inactivated toxins (toxoids); or highly purified subunits, the antigenic components of microorganisms that have been purified from cultures by chemical or physical processes, or have been produced by recombinant DNA techniques (Fig. 3.1).
TABLE 3.1 ■
The Advantages and Disadvantages of Living and Inactivated Vaccines
Advantages of Killed Vaccines
Advantages of Modified Live Vaccines
No reversion to virulence or toxicity
Stimulates CMI in addition to antibodies
No mutation or recombination
Stable on storage
No need for adjuvants
No residual virulence
Fewer boosters required
Fewer regulatory constraints
Can be used on mucosal surfaces
CMI, Cell-mediated immunity.
Fig. 3.1The many ways by which bacteria and viruses can be incorporated into nonliving vaccines.
Methods of inactivation
Organisms killed for use in vaccines must remain as structurally similar to the living organisms as possible. Therefore crude methods of killing that cause major changes in antigen structure as a result of protein denaturation are usually unsatisfactory. Chemical inactivation must not alter the structure of the antigens responsible for stimulating protective immunity. One such chemical is formaldehyde, which cross-links multiple lysine residues on the toxin to form highly stable methylene bridges. These confer structural rigidity on these proteins and neutralize their toxicity. Proteins may also be mildly denatured by acetone or alcohol treatment. Alkylating agents that cross-link nucleic acid chains are also suitable for killing organisms because by leaving the surface proteins of organisms unchanged, they do not affect their antigenicity. Examples of alkylating agents include ethylene oxide, ethyleneimine, acetyl ethyleneimine, and β-propiolactone, all of which are used in veterinary vaccines (Fig. 3.2).
Fig. 3.2The cross-linking effect of formaldehyde by generating methylene bridges. The figure also shows the structure of binary ethyleneimine and β-propiolactone, two major microbial inactivating agents used in veterinary vaccines.
Bacterins
Vaccines containing whole, killed bacteria are called bacterins. The bacteria can be grown in large volumes in bioreactors. It is usual to then kill the bacteria with formaldehyde and add aluminum or oil-emulsion adjuvants. The formaldehyde can be neutralized with sodium thiosulfate or sodium bisulfite. The antibody responses to these vaccines are directed against many different bacterial antigens, both essential and unimportant. The immunity produced by these simple bacterins is relatively short-lived, usually lasting no longer than one year and sometimes considerably less. For instance, a formalized swine erysipelas (Erysipelothrix rhusiopathiae) bacterin protects pigs for only four to five months. Streptococcus equi bacterins protect horses for less than one year, even though recovery from a natural case of strangles may confer a lifelong immunity.
One important issue, especially when using coliform and Campylobacter bacterins, is that of strain specificity. Multiple strains of each organism occur in nature, and successful vaccination requires immunization with appropriately matched strains. This is sometimes not possible if a commercial vaccine is employed. One method of overcoming this difficulty is to use autogenous vaccines. These are vaccines that contain organisms obtained either from animals on the farm where the disease problem is occurring, or from the infected animal itself. These can be very successful if carefully prepared because the vaccine will contain all the antigens required for protection in that specific location. As an alternative to the use of autogenous vaccines, some manufacturers produce polyvalent vaccines containing a mixture of antigenic types. For example, leptospirosis vaccines commonly contain up to five different serovars. This practice, although effective, is inefficient because only a few of the antigenic components employed may be required in any given location.
Although simple to make and generally inexpensive, bacterins are not always effective. They also may contain unwanted toxic components such as endotoxins. For this reason, many companies purify bacterins at additional cost. Remember too that not all the antigens in a bacterium can trigger a protective immune response. Some antigens, such as those found on the bacterial surface, are of much greater importance than internal proteins. Thus to the extent afforded by economics, efficacy, and safety, inactivated vaccines may be purified. Killed bacterial vaccines are usually stable in storage so that maintenance of the cold chain is not a major issue. Once the antigens are purified, then the vaccine can be formulated by adding adjuvants to enhance its immunogenicity and stabilizers to increase its storage life. If it is to be used in multidose vials, then preservatives must also be added.
Toxoids
Many bacterial pathogens cause disease by producing potent exotoxins. The most important are toxins from the Clostridia: Clostridium tetani, Clostridium perfringens, and Clostridium botulinum. The immunoprophylaxis of tetanus is restricted to toxin neutralization. Cl. tetani produces a toxin called tetanospasmin. This acts on presynaptic motor nerve cells to cause excessive motor neuron activity leading to extreme muscle spasms, respiratory paralysis, and death. Growing Cl. tetani in a semisynthetic medium produces large quantities of toxin. The toxin is released into the supernatant and can be treated with formaldehyde to fix the protein and block the conformational changes that make it toxic. It is then called tetanus toxoid. Next, the supernatant is ultrafiltered to get rid of unwanted proteins. Toxoids are available for most clostridial diseases and for infections caused by Mannheimia haemolytica. A toxoid is also available for vaccination against bites from Crotalus atrox, the Western diamondback rattlesnake.
Tetanus toxoid with an aluminum hydroxide adjuvant is given by intramuscular injection for routine prophylaxis, and a single injection of this vaccine will induce protective immunity in 10 to 14 days. The antibodies directed against the toxin have a higher affinity for the toxin than does the toxin receptor. Thus in infected wounds the antibodies bind the toxin as it is produced. The toxin molecules cannot therefore bind their receptors on neurons and are effectively neutralized. Antitoxins to the other clostridial toxins such as Cl. botulinum or Cl. perfringens act in a similar matter.
Toxoids are safe and cannot revert to virulence. They cannot spread to other animals. They are very stable and resistant to damage by temperature and light. They generally induce good humoral immunity but not cell-mediated immunity. As with other nonliving vaccines, toxoids are not always highly immunogenic. As a result, multiple doses may be needed to assure immunity. Additionally, an adjuvant, usually an aluminum salt, must be incorporated into the vaccine. Local reactions such as redness, swelling, and induration at the injection site may develop within a few hours. These usually resolve within 72 hours.
Conventional immunological wisdom would suggest that the use of antibodies against tetanus toxin (tetanus immune globulin) should interfere with the immune response to toxoid and must therefore be avoided. This is not a problem in practice however, and both may be successfully administered simultaneously (at different sites) without problems. This may be because of the relatively small amount of immune globulin usually needed to protect animals.
Bacterin-toxoids
Some veterinary vaccines combine both toxoids and killed bacteria in a single dose by the simple expedient of adding formaldehyde to a whole culture. These products, sometimes called anacultures or bacterin-toxoids, are used to vaccinate against Clostridium haemolyticum and Cl. perfringens. Trypsinization of the mixture may make it more immunogenic. Other bacterin-toxoids may have improved efficacy by adding other purified immunogenic antigens. For example, Escherichia coli bacterins against enteric colibacillosis in calves and pigs may be made more effective by the addition of additional fimbrial adhesion proteins such as F4 (K88), F5 (K99), F6, F7, and F18. Antibodies to these antigens prevent Escherichia coli binding to the intestinal wall and thus contribute significantly to protection. Similarly, Mannheimia bacterins enriched with the white cell-killing leukotoxoid are more effective than conventional bacterins in preventing bovine respiratory disease.
One problem with the use of whole killed organisms in vaccines is that they contain many components that are either nonantigenic or induce nonprotective responses, or, most importantly, may be toxic or allergenic. Thus in the interests of safety and efficacy it is often desirable to isolate and purify individual microbial antigens or subunits. These subunit vaccines may be isolated by classical physicochemical fractionation techniques or by gene cloning. Subunit vaccines only contain a part of the target organism and as a result vaccinated animals only respond to those subunits. By definition they are noninfectious and nonreplicating. Their great advantages include not only increased safety and reduced toxicity, but also the potential to use antibody assays to distinguish vaccinated from infected animals.
An example of the importance of subunit vaccines is seen when vaccinating against either Bordetella pertussis in children or Bordetella bronchiseptica in dogs. Originally these infections were controlled by the use of whole heat-killed bacterial vaccines. Unfortunately they had significant toxicity and induced inflammation and "soreness" in vaccinated children. Because of these problems, there has been a transition to the use of "acellular" vaccines. These contain a mixture of purified bacterial subcomponents. There are several different vaccines of this type because there is no consensus on the ideal composition of an acellular vaccine. They differ in the number of subunits included such as pertussis toxin, filamentous hemagglutinin, outer membrane proteins, or fimbrial antigens. These acellular vaccines also contain much less endotoxin and are thus considerably less toxic than whole cell vaccines. Although widely accepted, they are somewhat less effective with a shorter duration of immunity besides being more expensive.
Core antigens
Another approach to the development of subunit vaccines against gram-negative bacteria is the use of common core antigens. The outer layer of the gram-negative bacterial cell wall consists of lipopolysaccharide. This lipopolysaccharide is formed by a variable oligosaccharide (O antigen) bound to a highly conserved core polysaccharide and to lipid A. The O antigen varies greatly among gram-negative bacteria so that an immune response against one O antigen confers no immunity against bacteria expressing other O antigens. In contrast, the underlying core polysaccharide is conserved between gram-negative bacteria of different species and genera. Thus an immune response directed against this common core structure has the potential to protect against many different gram-negative bacteria. Mutant strains of E. coli (J5) and Salmonella enterica Minnesota and Typhimurium (Re) have been used as sources of core antigen. J5 is a rough mutant that is deficient in uridine diphosphate galactose 4-epimerase. As a result, the organism makes an incomplete oligosaccharide side chain, and has lost most of the outer lipopolysaccharide structure. Immunization with a J5 bacterin thus provides protection against multiple gram-negative bacteria such as E. coli, Klebsiella pneumoniae, Actinobacillus pleuropneumoniae, and Haemophilus influenzae (type B). A J5 bacterin has also been reported to protect calves against organisms such as S. enterica Typhimurium and E. coli, and pigs against A. pleuropneumoniae. The most encouraging results have been obtained when vaccinating against coliform mastitis (Chapter 16).
Glycoconjugate vaccines
Many important bacterial antigens consist of capsular polysaccharides or glycoproteins whose immunogenic structures are carbohydrate side-chains. Unlike protein antigens that trigger T cell-dependent B cell responses, bacterial polysaccharides cannot bind to MHC molecules and hence cannot trigger T cell help (They are "T-independent"), and they also cannot trigger the reactions needed for survival, affinity, maturation and extensive B cell proliferation. As a result, B cells can only produce low affinity immunoglobin (Ig)M antibodies against polysaccharides. They do not induce an IgM to IgG switch, they fail to induce a booster response, and they do not induce T cell memory. Thus pure bacterial polysaccharides are very poor vaccine antigens (Fig. 3.3).
Fig. 3.3Immune responses to carbohydrate antigens and to glycoconjugate vaccines. T-independent antigens such as polysaccharides do not stimulate a class switch, they do not increase in antibody affinity, and they do not stimulate immunologic memory. They make very poor vaccines until chemically linked to a protein carrier molecule. Ig, Immunoglobin.
Recombinant vectored vaccines
Living vaccines
A brief history of veterinary vaccines
Fish vaccines
Passive immunization
Failures in vaccination
Feline vaccines
Nucleic acid vaccines and reverse vaccinology
Tags: Vaccines for Veterinarians
Jan 21, 2021 | Posted by admin in GENERAL | Comments Off on Nonliving vaccines


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SilverSingles offers serious 50+ dating. This means that if you're one of the millions of singles over 50 out there, and you're looking for love and companionship, our dating site is the one for you! Other dating sites are bigger and flashier, but you're best served by a dating site that suits your needs. If you want a serious relationship for your golden years, don't waste your time - sign up for SilverSingles today!
Why it's awesome: On OkCupid, users can offer a ton of information about themselves through the site's Match Questions. Examples include: "Would you date someone who keeps a gun in the house?" or "Should the government require children be vaccinated for preventable diseases?" The answers to these questions help OkCupid determine which members might be a good match for one another. Of note: Per OkCupid's own stats, liberal women in particular have luck on the site. And in 2017, the site offered users the chance to answer 50 "current events" questions that illuminate a user's politics."OkCupid has been a favorite of mine for years," Spira says. "I always liked OkCupid because they have a great critical mass and they have the thought-provoking questions that really allow you to think about how you feel about some of these issues, whether it's politics or gun control, and how do you feel about your date's answers. People spend a lot of time on site just perusing the questions that other people answer, and I like that."
Traditional Internet dating can be challenging for those singles looking for love that lasts - but eHarmony is not a traditional dating site. Of all the single men or women you may meet online, very few will be compatible with you specifically, and it can be difficult to determine the level of compatibility of a potential partner through methods of conventional dating services – browsing classified ads, online personals, or viewing profile photos. Our Compatibility Matching System does the work for you by narrowing the field from thousands of single prospects to match you with a select group of compatible matches with whom you can build a quality relationship.
eHarmony was one of the pioneers in the online dating space, and -- while I haven't personally used this one -- we all remember the pitch, thanks to years of TV commercials: The service matches couples based on "29 dimensions" of compatibility (as determined by a thorough relationship questionnaire). While you can review the profiles of your prospective matches for free, you'll need to pay to unlock the full features of the service. But that comes with a guarantee: If, after three months of paid membership and communicating with at least five members, you're not satisfied, eHarmony will refund your money. Despite a rocky road that eventually involved a high-profile lawsuit, the site finally added same-sex dating in 2013, too. I have mixed feelings about using the site myself, but the site is at least technically more inclusive now.
If you want to know more about someone, you can always just ask the friend you have in common, which is a human touch that's absent from most apps. Moreover, people can message you only if you've matched, so there are no unsolicited "greetings". You can see what sort of relationship people are looking for, and while that doesn't sound that revolutionary, it reflects the fact that Hinge carries more of a dating expectation than a just-hooking-up expectation à la Tinder. Furthermore, because of the friends-of-friends connection, you're less likely to run across inappropriate photos. That's a plus in our book.
And of course, you'll want to be using the right dating app to get the job done. Luckily, you're looking for a casual encounter at a time when new apps and features are constantly evolving to help you find exactly what it is you're looking for. Not sure which apps to start with? Here are some of the best dating apps for hooking up, as well as our advice on how to use them to your advantage to get lucky tonight.
The thing is, there won't ever be some one-size-fits-all dating app that everyone loves and totally works: The point of these apps is to connect people, and people are sloppy. But out of all the tech that's pushed on us at all times, it's nice to know there are some apps out there that even the bitterest-about-dating among us can find some good in.
Your profile is the best way to make yourself known to singles around you or in another city. The good news is your profile is part of the basic functionalities of iDates. This means that your text description as well as the uploading of pictures is completely free. Free features include also the ability to read messages you receive from singles interested in you. Who knows, maybe the first message you'll receive will be from the one, who will win your heart?
On a flirting site, you don't need to do much. Just find singles you like, flirt online, and arrange a live date offline. Flirting is easy – you just stay positive, be humourous, and pay compliments to your other partner about their personality and profile. And remember, by flirting online you'll also pimp your skills in communicating and impressing with the opposite gender. Startflirt.com is a popular online dating site where 1000s of single girls and boys meet their soul mates. If you're looking for the same, try us and see that it's the best dating site for you. On our dating site for singles in search, we provide you with the opportunity to seek women and men.
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MeetMe is another one of those location-based dating apps. It features a simple. colorful interface that's easy to use. It also boasts over 100 million downloads and uses between all the various platforms. Its original intention is to be used as a way to meet people in your area. However, if enough sparks fly, those people can easily become more than just friends. The biggest issue with this one is the fake profiles and it's a fairly serious problem. However, most of these apps have fake profile problems so we're not sure when enough is enough. Still, we recommend this one for patient people and, by all means, if you can't find anything in a few weeks, get rid of it.
Why did I run away? It's kinda my thing. I'm a 23-year-old woman living in an age of swipeable romance, but until recently, I'd never used a dating app, or even really casually dated. Being single has always been enough for me, but when the new year struck, I wanted to make sure I wasn't shutting myself off from an experience that could be special. So I had decided to do the unthinkable: I, a dating app virgin, joined all the major dating apps with the goal of going on one date per app to help me get over my dating fears. I agreed to go out with anyone who asked and asked out anyone I was interested in.
The speeches of the preceding paragraphs, if duly considered and implemented, will help to share in a particularly more serene interpersonal relationships in Lovesflirt. This way is created a necessary environment, for a happy turn of people's lives based on what is called individual desires. I just have to renew my greetings to Welcome and so much happiness by Lovesflirt.
The timer is designed to encourage contact, and some people really do appreciate that feature. But if you're someone who procrastinates, Bumble may not be for you. Also because women must message first, Bumble tends to weed out the slightly more insecure males. However the rate of overly confident males tends to be higher than I've seen on other apps. Bumble also has a BFF feature, but that's really not the focus of a dating app gallery, so I'll save it for another time.
Get an amazing love experience here! Enter flirty chat rooms of girls, talk online with fun-loving flirts who are eager to find love-mates for dating adventures. Chat, meet new flirt-mates, choose a life partner or just flirt without any serious intent. Here you can meet single people worldwide from different preferences, tastes, ages and locations and get a life full of new exciting experiences. Come to this amazing site and enjoy the company of other flirty single girls and boys who match your dating criteria! Browse new profiles daily and choose the right companion faster than ever! Now you will become popular among pretty girls who will beg for a date with you! Free online dating site for flirting fun.
If you're strictly looking for a hookup app, it's always best to prioritize your privacy, and Pure does just that. The free app, designed to facilitate casual flings, erases your profile every hour (although you can easily restore it if your heart desires). The app is basically a geo-location-based online personals app that allows you to list yourself to other local singles for 60-minute periods to see who you match up with. If you mutually match, you can strike up a quick chat with the matching user, but be sure to exchange contact information quickly, as you'll lose contact on the app with that user. After one hour, your profile "self-destructs," erasing your short online personal listing so nothing traces back to you.
Sick of typical dating but still wanting to take the guesswork out of meeting people, she started to feel like she had to settle. But then, "I woke up one day and decided I wanted to have a threesome, and that's how I came to download Feeld," she says. She noted that the app immediately felt easier than Tinder or Bumble. "To start with, the fact that I was on there looking for hot and fun people to hook up with, and anyone I matched with was looking for the same, meant that I got to skip the awkward first few dates," she tells me. "It also meant that I knew what I was in for, so I was never worried about someone suddenly becoming a slimeball. It really helped me feel more confident at a time when I wasn't confident about dating."
Hinge may seem like it plays second-fiddle to the likes of Tinder, but it has a pretty elite user base (99 percent of its daters went to college, for example). Hinge's CEO compared his app to Facebook, versus Tinder's Myspace—sometimes for interface reasons (Hinge is aimed at the college-educated set) and sometimes for class reasons (much has been written on the ways dating app algorithms may favor white people).
Bumble also checks the boxes for usability, a slick user interface, and easy setup. In addition, the relatively ballsy move of designing a dating app specifically with women in mind pays off. It's the only app that clearly states plainly and prominently that it prohibits pornographic material, requires its users to respect one another, and has a code of conduct in place specifically to make it a safe and friendly place. We only found one other dating app that had a code of conduct — and it was hidden within the Terms of Use, which no one reads. The 24-hour time limit to connect with someone adds just enough pressure to say "hello," so matches don't languish and get reshuffled into the deck. And if you accidentally nixed someone? Just shake your phone to undo your rogue swipe.


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House on Defense Budget
By Deinde Falase
Interacting with the Chief of Defence Staff and his top officers, the Chairman House Committee on Defence, Bashir Adamu expressed the Committees condolences regarding the recent deaths of some Nigerian Military Personnel in Niger Republic. He used the occasion to advise that the Defence HQ do more to project its image as one respecting Human Rights, particularly regarding Military/Civilian relations.
Responding, Chief of Defence Staff, Admiral Ola Sa'ad Ibrahim expressed appreciation for the visit, describing it as being in the best interest of the Nation's democracy.
The brief on the 2012 budget performance of the Defence HQ was presented by the Chief of Logistics, Major-General Garba Audu, who identified late release of funds as well as inadequate funding as adversely affecting budget implementation.
The House Defence Committee was also at the Military Pension Board where the Chairman of the Board, Navy Commodore Dalacson Audu revealed that the sum of 101 Billion Naira is required to take care of the 53% increment in Military Pensions since 2010. The Chairman, House Committee on Defence, agreed with the urgent need to settle the outstanding arrears.
A suggestion was also made for the Military Pension Board to open zonal offices so that Military Pensioners in different parts of the country can readily have access to the board.
Newer PostRoad Pavement Workshop
Older PostFG Surveyors and Development


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Edward Anderton Reade,  (15 March 1807 – 12 February 1886), was a British civil servant in India who served in Bengal from 1826 to 1860.

Career
On 10 February 1835 Reade was appointed as Joint Magistrate and Deputy Collector of Belah. On 8 September 1836 he was appointed as Magistrate & Collector of Goruckpore. He was given additional responsibility, on 24 October 1836, as Deputy Opium Agent for management of provision of opium in Goruckpore. He remained collector of Goruckpore (at least) till October 1844.

During 1857 Reade was Commissioner of the Fifth Division and Commissioner of the Benares Division. From 10 September 1857 to 30 September 1857 he held the position of Lieutenant-Governor of the North-Western Provinces as an In charge (acting). He retired from the East India Company in 1860 and returned to the family home in Ipsden, Oxfordshire, where he served as a magistrate for Oxfordshire and Berkshire.

He was a brother of the novelist Charles Reade, and the father of the New Zealand cricketer Lawrence Reade.

Works
His works include:

 Minute on the Roads in the Azimgurh District

References

External links
 INDIA-L Archives
 English village architecture By R. J. Brown
 Bulletins and other state intelligence #2149
 Empire and Information By Christopher Alan Bayly
 Official Descriptive and Illustrated Catalogue By Great Exhibition, Robert Ellis, Great Britain. Commissioners for the Exhibition of 1851 #859

Companions of the Order of the Bath
British East India Company civil servants
Indian Civil Service (British India) officers
Lieutenant-Governors of the North-Western Provinces
1807 births
1886 deaths

redpajama_set_name: RedPajamaWikipedia


Kevin Rudd has declared that Labor is the party of ''nation building''. Tony Abbott wants to be an ''infrastructure prime minister''. For once the lofty political rhetoric matches a genuine national need.
Australia has a huge infrastructure backlog, amounting on some estimates to 40 to 50 per cent of gross domestic product. Unfortunately the current national policy settings for the financing, funding and building of infrastructure will come nowhere near delivering on the aspirations of our leaders.
But a very big idea is taking hold among leading Australian policymakers, economists, business executives, the labour movement and the superannuation sector. In essence it involves a new co-operative approach to infrastructure investment in which government plays a much bigger role in the financing of projects, together with improved transparency and an independent assessment of productive returns. Suitable projects would then be privatised, providing a source of funds to be recycled for the next project, and opening up attractive investment opportunities for Australia's $1.6 trillion in superannuation savings.
This proposal is now being pushed in various forms by no fewer than five former or current Reserve Bank board members: Bernie Fraser, Heather Ridout, John Edwards, Warwick McKibbin and Bob Gregory.
There is also a concerted push to overthrow the orthodoxy of the past two decades that ''all government debt is bad'' - a view that has become a handbrake on national development. Last week the chief executive of National Australia Bank, Cameron Clyne, put the argument succinctly when he said, ''Australia has a debt problem - we don't have enough.'' Like most executives, he knows that any chief executive who had a balance sheet as lazy as those of Australia's governments would almost certainly get the sack.
Co-operation and Development (OECD), Estonia, has a lower figure. But unlike Estonia, Australia is a big country enjoying sustained population growth, and desperately needs new infrastructure.
Australia also faces a huge macro-economic challenge as the resources boom moves from the investment to the production phase. Policymakers need to find new ways to stimulate large-scale public infrastructure investment.
As a second step to building a better Australia, the Commonwealth government should take a more active role in the financing of infrastructure.
While state governments have the capacity to borrow more than they do at present, the federal government currently enjoys a 70-basis-point lower borrowing rate than even a strong state such as Victoria. This translates into huge interest savings given the debt levels on large-scale projects.
With this in mind, economists Peter Sheehan and Bob Gregory have suggested the establishment of a joint Commonwealth-state body, Infrastructure Financing Australia, to finance projects with a high rate of return backed by a Commonwealth government guarantee. The states would then fund the infrastructure from their operating budgets, or other means. The budget outlook for the states in the short term is problematic, but over the longer term it may be more positive with resource royalties rising as the vast array of new resource projects come on stream. Through the GST and fiscal equalisation, this budget boost should also flow through to the non-resource states.
A further element of this arrangement, suggested by economist Warwick McKibbin, involves setting up an explicit capital account in the Commonwealth government accounts, accompanied by the issuance of 15-to-20-year government debt. If sold at current world interest rates, the cost of servicing this debt would be locked in at very low levels for a very long time.
The third step in the plan is to ensure the political process does not lead to expensive infrastructure investment mistakes, but rather to the endorsement of proven, productive projects. State governments must retain the role of making the final decision on project selection, but a rigorous, arm's-length, independent process needs to confirm the rate of return offered on a project.
The establishment of Infrastructure Australia in 2008 has been a valuable institutional development towards this objective. It now needs to be given real teeth as an independent body to assess infrastructure projects.
Finally, once these projects are built, they should where suitable be privatised, to create a return to the states and allow them to recycle the funds into the next project.
The privatisation of ports Botany and Kembla in May by the NSW government is a model for how this new arrangement can work. The ports were purchased by 5 million Australians through their industry super funds, meaning about one in two workers in NSW now owns a share of these facilities. Meanwhile, the state Treasurer has recycled the sale proceeds to kick-start a major new toll road.
Increasing public investment in infrastructure is one of Australia's most pressing macro-economic challenges. What we need now is a national leader with the capacity and courage to embrace these reforms and make good on their aspiration for Australia.
Nicholas Reece, public policy fellow at the University of Melbourne's Centre for Public Policy, is a former senior adviser to prime minister Julia Gillard and premiers Steve Bracks and John Brumby.


Copiapó was officially founded in 1744 by Don Francisco Cortés, who called it Villa San Francisco de La Selva. Originally a tambo, or resting place, it was also the spot where Diego de Almagro recuperated after his grueling journey south from Peru in 1535. In the 19th-century silver strikes solidified Copiapó's status as an important city in the region, and today most residents make their living from copper mining. The city itself is modern and prosperous, with a lovely central park lined with 100-year-old pepper trees and plenty of flower-filled avenues. You can also see the site of South America´s first train station, built in 1852, which once ran to the coastal port of Caldera.


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Joseph Di Salvo was elected to the Santa Clara County Board of Education in 2008, served as Board president in 2010 and 2011, and was re-elected in 2012 and 2016. He began his 33-year career in education as a teacher at Osborne School in Juvenile Hall, an SCCOE school. He has been a teacher, director, and principal in the county, serving as union president for Santa Clara County teachers. He also served for three years as a personnel commissioner for the SCCOE. In 2001, he was recognized as the Association of California School Administrators (ACSA) Region 8 Administrator of the Year. He is in his eighth year as a mayoral-appointed citizen representative to the San Jose Arena Authority, currently serving the last year of his second term as chair.
A lifelong San Jose native, Mr. Di Salvo graduated from St. Joseph's Grammar School and Bellarmine College Preparatory School before attending San Jose State University, where he earned an undergraduate degree and a master's degree in education.
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Bring the boogie to your hen party with this glam Reading 70s Dance Class! You and the girls are going to learn all the moves to some of the most famous dance crazes of the decade. Bring mini skirts and flares, and get into the groove!
The 70s were responsible for some of the most danceable tunes in history. Your hen party will be breaking out the funk to massive hits from acts like The Bee Gees, Donna Summer and Lipps Inc. And if you have a particular tune you'd like to hear, we'll do our best to make sure it gets on the stereo.
Worried you won't be able to keep up with the music? Your professional instructor knows just how to get a hen party up and moving. Each disco routine will be taught step by step, and you'll spend as long as you need on every element of the dance.
This high energy, fun disco dance class takes place in a private venue in Reading. You get two hours to learn the moves, and with no-one watching you really can throw your hands in the air like you just don't care! We recommend getting into the mood with some hen party fancy dress. Big wigs, shades and flares are all perfect. So come on girls, let's get on down to Funky Town!


The survival outcome for children with cancer has improved dramatically over the past 50 years . In developed nations, the cure rates of childhood cancers now exceed 80%, whereas, in the 1960s, cure rates in children with cancer were the opposite: 20% [2, 3]. This remarkable increase can be attributed to a multitude of factors including the introduction of intensive treatment protocols and highly coordinated modern multidisciplinary care. However, these treatment modalities (mainly chemotherapy, radiotherapy, and surgery) also have clear undesirable side effects, both short- and long-term. Of these, pain is among the most prevalent and distressing [4, 5].
Besides improving survival outcome, an important focus in present day pediatric oncology is reducing morbidity and improving quality of life during and after treatment. This is referred to as supportive care, which the Multinational Association of Supportive Care in Cancer defined as "the prevention and management of the adverse effects of cancer and its treatment across the cancer continuum" . As the field of supportive care is extremely broad, healthcare professionals often seek guidance on how to optimally assess and manage the undesirable effects of anti-cancer therapy . To provide this guidance, the project "Towards evidence-based guidelines in childhood cancer" was initiated in 2014 .
As the first step in this project, we surveyed health care providers to determine the topic areas in which they wanted guidance. Pain assessment, evaluation (i.e., interpretation of the assessment to evaluate treatment effect), and management were identified as priorities [8, 9]. Regarding pain assessment, one of the great challenges in pediatric oncology is selecting measurement instruments that are age-appropriate, clinimetrically sound, and facilitate measurement of the various types of pain that children and adolescents with cancer experience.
In previous research, the focus has been placed upon synthesizing knowledge regarding pain measurement tools used with other populations. A systematic review on pain intensity assessment tools for adults concluded that numerical rating scales are applicable for unidimensional assessment of pain intensity in these patients . Another recent systematic review focused on non-responsive adults and found that there are multiple observational pain assessment tools available for this population . However, there are clear differences between children and adults, and there are various types of pain that children with cancer experience (e.g., neuropathic pain) that require specific guidance.
Thus, this systematic review will focus on assessment and evaluation of pain and pain-related distress and is an essential step in the development of a clinical practice guideline regarding pain in children and adolescents with cancer. For this guideline, the international guideline development panel consists of 46 members (including pediatric oncologists, nurses, anesthesiologists, pharmacologists, psychologists, and patient representatives) divided into a core group (leads, coordinators, advisors) and six working groups. Recommendations will be developed for assessment and evaluation of pain, as well as for pharmacological, physical, and psychological management of tumor-, treatment-, and procedure-related pain.
The Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) statement has been followed in the development of this systematic review protocol . The completed PRISMA-P checklist can be found in Additional file 1.
Studies that evaluate instruments that aim to measure the construct of pain (all types of pain). Distress is also taken into account, when related to pain assessment.
Studies that encompass children and adolescents with cancer, defined as (1) all participants < 25 years old or a median ≤ 16 years old or a mean ≤ 16 years old and (2) at least 75% of participants are diagnosed with cancer.
Studies that investigate a relevant measurement instrument, which differs per clinical question and is either self-reported (e.g., visual analog scale (VAS)) or a behavioral pain/distress measurement instrument (e.g., the COMFORT scale) [13, 14].
At least one relevant outcome should be included. For all clinical questions, relevant outcomes are reliability, validity, responsiveness, interpretability, and clinical utility (as defined by COSMIN, see Table 1).
Only primary, quantitative studies will be included. The sample size per study should be at least ten participants. Studies should clearly state their aim is to evaluate the clinimetric properties of an existing measurement instrument or to develop a new measurement instrument (this criterion is in line with COSMIN) . Studies need to be published in a peer-reviewed medical journal, with a full text available in the English language.
The searches will be conducted in four electronic databases, i.e., the Medical Literature Analysis and Retrieval System Online (MEDLINE, via PubMed), the Cumulative Index to Nursing and Allied Health Literature (CINAHL), the Psychological Information Database (PsycINFO), and the Health and Psychosocial Instruments Database (HaPI). As an example, the full search strategy that will be used in PubMed/MEDLINE can be found in Table 2. For identification of additional studies that were not included in this search, we will check all references of included studies (backwards citation chasing) and all studies that referenced the included studies (forward citation chasing). Also, we will consult experts for missing studies that meet the inclusion criteria. In addition, to identify promising ongoing and recently completed studies, we will hand search (1) conference proceedings of the International Society on Pediatric Oncology (SIOP) (2012 to 2017), the American Society of Clinical Oncology (ASCO) (2012 to 2017), the American Academy of Pediatrics (AAP) (2012 to 2017), the International Symposium on Pediatric Pain (ISPP) (2012 to 2017), the American Academy of Pain Medicine (AAPM) (2012 to 2017), the European Pain Federation (EFIC) (2012 to 2017), and the Multinational Association for Supportive Care in Cancer (MASCC) (2012 to 2017), dependent on availability and (2) the trial registers of the National Institute of Health (NIH) Register for ongoing trials and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP).
All citations that will be identified in the database searches will be imported in EndNote X8 (Clarivate Analytics, Philadelphia, PA, USA) after which duplicates will be removed. For appraisal of the citations, we will use exported Microsoft Excel files (Microsoft, Redmond, WA, USA).
We have developed an algorithm that will be followed in the phase of evidence appraisal (see Fig. 1). The study selection will consist of three phases.
As we expect a large total number of citations, the first round will consist of selection based on titles only. A recent study that compared screening titles alone versus titles and abstracts concluded that screening on title alone may be more effective . The entire selection will be performed in duplicate by two independent reviewers (with extensive experience in both pediatric oncology and in systematic reviews, 1: EL, 2: WT). This serves to exclude studies that are obviously irrelevant for this review. A conservative approach to inclusion will be employed to ensure relevant titles are not excluded. All citations classified as "include" by at least one reviewer will be included, even if the second reviewer classified the citation as "exclude" (no discussion will be held). It should be noted that this conservative approach is only applied during the title selection phase. During abstract and full-text selection, all discrepancies will be discussed in detail and resolved by consensus.
To pilot the title selection process, two reviewers will appraise the first 250 citations. If there is an agreement below 85% percent, the title selection criteria will be optimized and the pilot will be repeated on the next 250 citations. This continues until the agreement is at least 85%.
The second round will consist of selection based on title and abstract. The entire selection will be performed in duplicate by two independent reviewers (1: EL, 2: divided among JS, KB, MD, KK, MR, MW, and FG). A pilot will be performed with the first 100 citations in a similar fashion as with the title selection pilot. Hereafter, discrepancies will be resolved by consensus, and if this is not reached, a third reviewer will be consulted.
In the final selection round, two independent reviewers (the same as in the second round) will perform the selection of the full texts. Discrepancies will be resolved by consensus, and if this is not reached, a third reviewer will be consulted.
Two reviewers will independently extract data from each included study using a data abstraction form designed for this systematic review (see Additional file 1). This form will be pilot-tested by two reviewers with a representable sample of studies and, if necessary, optimized according to the reviewers' comments. The data extraction form differs slightly for each clinical question, but includes at minimum (1) general study information (i.e., first author, title, journal, year, funding source), (2) study design characteristics (i.e., study design, setting, duration, sample size), (3) participant characteristics (i.e., age, gender, diagnosis, age at diagnosis, type of pain), (4) measurement instrument characteristics (i.e., instrument used, measurement method/dimensions), (5) outcome characteristics (i.e., included outcomes, outcome values), and (6) additional information (differs per study, at the discretion of the reviewer). Reviewers will discuss the completed forms, and discrepancies will be resolved by consensus. If consensus is not reached, a third reviewer will be consulted. In case of missing information, the authors of the included study will be contacted in an effort to obtain this information.
Two reviewers will independently assess the quality of the included studies, according to the COSMIN checklist for assessing methodological quality of studies on measurement properties [15, 19]. This checklist is purpose-built for the evaluation of measurement properties and takes a three-tier approach. For multi-item measures, it is first determined if the statistical methods are based on the classical test theory (CCT) or on the item response theory (IRT); in the case of the latter, a separate quality checklist is included. Second, a checklist is completed for each measurement property evaluated in each included paper to evaluate if standards for good methodological quality are met. Third and last, a checklist regarding the generalizability of each outcome is completed. Discrepancies between reviewers will be resolved in the same manner as described for data extraction.
The COSMIN 4-point checklist scoring system will result in a score per included outcome for each study that can either be "excellent" (evidence that the methodological quality is adequate), "good" (assumed that the methodological quality is adequate, but relevant information is not reported), "fair" (doubtful whether the methodological quality is adequate), or "poor" (evidence that the methodological quality is not adequate). This serves the purpose of identifying the measurement tool with the strongest clinimetric properties.
Regarding publication bias, we will seek to identify cues that imply this bias, e.g., identification of merely studies that report measurement instruments with strong clinimetric properties. A prospective registration database, as there is for randomized controlled trials, does not exist for measurement properties studies, which makes identifying publication bias particularly hard in this area of research. Also, there is no established methodology for this, e.g., as there is for a meta-analysis with a funnel plot. Therefore, we will comment upon this in a qualitative manner.
Firstly, we will prepare a table of characteristics of included studies where information regarding design, sample, measurement instrument(s), and outcome(s) will be presented. Outcome tables will be prepared to cover each measurement instrument (e.g., the Comfort Behavior Scale) and each outcome construct (e.g., self-reported pain intensity) separately. In addition, an outcome table will be prepared which categorizes instruments according to age group, i.e., 0–0.99 years (infants), 1–2.99 years (children not able to speak or read), 3–6.99 years (children able to speak, not able to read), 7–12.99 years (children able to speak and read), and 12–18 years (teenagers). If the identified evidence leads to the conclusion that differently defined age groups are more appropriate, we will reconsider the definition of the age groups.
To provide a comprehensive overview, we will develop a quality matrix. Herein, we will list all included measurement instruments and the identified information on purpose (self- or observer-report, type of pain), number of studies, population/age group, and per outcome COSMIN quality score (four-level). This will allow the reader to quickly identify the appropriate measurement instrument with the strongest clinimetric properties.
In addition, we will present a narrative synthesis discussing our findings.
In this protocol, we describe our approach for a systematic review regarding measurement properties of instruments to assess pain and pain-related distress in children and adolescents with cancer. This overview is much needed for multiple reasons.
First, there is a clear difference between adults and children. Second, besides this difference, there is also a great difference between children across ages (e.g., a 15-year-old and a 3-year-old). Children go through various developmental stages which lead to great variation in this population in terms of abilities in verbal communication, pain experience, and associative thinking, which will determine the appropriateness of individual instruments within specific age groups . Although self-report is often regarded as the ideal method for assessing pain, in young children, this is not always possible. Therefore, these populations have to rely on the people around them (family members but also healthcare professionals) to notice and act upon their pain. This underlines the importance of having clinimetrically sound measurement instruments not just for self-report, but also for proxy report. Third, children and adolescents with cancer have various specific types of pain which are often related to their disease (e.g., bone pain due to metastases) or treatment (e.g., procedural pain, vinca alkaloid-associated neuropathic pain). Fourth, pain severity measurement is the critical first step to determine the need for treatment and to evaluate the success of treatment. When pain is not measured, it is often undertreated . All of these reasons call for age-specific measurement instruments with strong clinimetric properties to assess pain in children and adolescents with cancer.
Currently, there is great interest in reducing the side-effects of cancer treatment in children and adolescents, to reduce morbidity and improve quality of life. Pain is frequently experienced by children and adolescents with cancer and carries with it a great physical and psychological burden . It is known that not acknowledging and treating pain can have a detrimental effect on quality of life . Therefore, it is of utmost importance that healthcare professionals have access to the available evidence and evidence-based recommendations for care.
To address these needs, we have initiated a clinical practice guideline development project that focuses on formulating recommendations on the assessment and treatment of pain in children and adolescents with cancer. This systematic review of the literature describing pain measurement instruments is the first step towards formulating these recommendations.
We thank Edith Leclercq for critically reviewing the search strategy and running the initial searches in order to check the correctness of the strategy and identify necessary changes.
The project "Towards evidence-based guidelines for supportive care in childhood oncology" is supported by the Alpe d'HuZes foundation/Dutch Cancer Society (RUG 2013–6345). The editorial base of Cochrane Childhood Cancer is funded by Stichting Kinderen Kankervrij (KiKa). The funding source had no role in the study design, in the preparation of the manuscript, or in the decision to submit the manuscript for publication.
EL contributed in defining the clinical questions and the conceptualization and design of the review and drafted the manuscript. JS, KB, MD, KK, MR, AF, LD, ED, RM, FC, MW, and FG contributed in defining the clinical questions and the conceptualization and design of the review. WT is the guarantor for the review, contributed in defining the clinical questions and the conceptualization and design of the review, and drafted the manuscript. All authors critically reviewed the protocol and manuscript. All authors read and approved the final manuscript.
Erik A.H. Loeffen is an associate editor of Systematic Reviews. All other authors declare no competing interests.


I am an actor living in the Los Angeles area and a recent graduate of ART/Harvard in Cambridge, where I earned my MFA in Acting. I've worked in a variety of media, on material ranging from Shakespeare to musicals to TV comedy and devised physical theatre pieces. I'm thrilled about the work I've been able to do so far, and I'm eagerly making the most of the wealth of opportunities in LA (and the avocados).


On July 17, 2014, we went to Ocean Shores (0.5 mile south of the Elk Creek River) for another marine debris research.
The arrival situation will give us a view of the overall situation of Asian originated marine debris traveling along the Kuroshio (Black Current) and some of them are reaching the beaches of the Pacific Northwest. With a total of 28 Asian marine debris found, it was the most we have found so far. We also found the most debris originating from Japan than we have in the past. Among those, was a propane tank, which you can view below. Due to its potential hazard on the shore, we called the Washington State Department of Ecology to retrieve the tank.
Information: May have been used for oyster cultivation.
Information: Marked on the side is company name, "Daigo"
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Serie A giants seeking loan before £22m purchase of Chelsea centre back
Date:2nd August 2017 at 7:00pm
Italian newspaper Tuttosport (via Tuttomercatoweb) are reporting that Inter Milan are continuing their pursuit of Chelsea defender Andreas Christensen.
The Danish international will be reportedly given chances in the first team by Antonio Conte this season after spending two seasons on loan at Borussia Monchengladbach, and Chelsea are said to have already rejected a bid from the German side to sign the 21 year old on a permanent basis.
Still, it seems Inter will look to try their luck. They want the player on an initial season long loan in view to a permanent transfer next summer. It seems the Serie A club are flexible on whether it is a purchase option or an obligation to buy, but they are said to be prepared to offer only between €20m (£17.9m) and €25m (£22.4m) for the player.
Along with Inter, Turkish newspaper Sozcu reported yesterday that Fenerbahce were also keen on the centre back as they seek a replacement for defender Simon Kjaer who is close to joining Sevilla.


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Craufurdland Estate
Craufurdland Estate Set to Expand their Outdoor Activity Centre with the help of BLS
Craufurdland Estate set to expand their outdoor activity centre.
Due to increased demand for outdoor activities, Craufurdland Estate receives £50,000 growth loan.
Set in 600 acres of stunning Ayrshire countryside, Craufurdland Castle has been home to the Craufurds of Craufurdland since 1245. Since 2011, owners Simon and Adity have opened and transformed the estate into a family-friendly outdoor activity and hospitality venue. The estate boasts a range of activities ranging from Fishing, Mountain Biking to Adventure Runs. Most recently the team at Craufurdland have expanded into the hospitality sector by building and launching the Laird's Table. A casual restaurant serving the finest, locally sourced, fresh and impeccable food where guests can enjoy uninterrupted views of the Ayrshire countryside. The castle can also be booked for exclusive use staycations and corporate events.
Craufurdland Estate has now secured a funding package of £205,000, £50,000 of which Business Loans Scotland has provided. This funding will enable them to realise their new outdoor activity project which will see the introduction of a Tree Top High Wire adventure course which will feature a Zip Wire for adventurers of all ages.
Upon receiving the funding, Simon Douglas Houison Craufurd, Laird of the estate said:
"The support we have received from BLS has been a crucial piece of the jigsaw to help us develop into a quality activity centre. Working with Mark, was a pleasure and his patience and understanding during these very difficult times has been a huge help in our success."
Andrew Dickson, Fund Manager of Business Loans Scotland added:
As a business involved in leisure, tourism and hospitality sector, the last 12 months have been extremely challenging for the Directors and staff. The Coronavirus pandemic effectively halted the business's expansion plans and when lockdown restrictions began to ease, I was delighted Business Loans Scotland was able to support Craufurdland with project and working capital finance to help the business complete its Tree Top Trials. As lockdown restrictions continue to ease and businesses involved in the leisure and hospitality sector start up again, I wish the company well in taking advantage of its new opportunities."
£50K
Growth Loan Provided
Simon Douglas Houison Craufurd
Laird of The Estate
"As a business involved in leisure, tourism and hospitality sector, the last 12 months have been extremely challenging for the Directors and staff. The Coronavirus pandemic effectively halted the business's expansion plans and when lockdown restrictions began to ease, I was delighted Business Loans Scotland was able to support Craufurdland with project and working capital finance to help the business complete its Tree Top Trials. As lockdown restrictions continue to ease and businesses involved in the leisure and hospitality sector start up again, I wish the company well in taking advantage of its new opportunities."
Andrew Dickson
Fund Manager of Business Loans Scotland
If you think you are ready to apply for funding and have all the relevant documents and information prepared according to our checklist, then you should proceed to submit an enquiry. One of our Loan Officers will be in touch to discuss your enquiry.
Green Cross Training
Training company set for UK wide growth.
The Glentress Hotel
The Glentress Hotel is located at the foot of the Glentress Forest and aims to provide great value accommodation and hospitality for those exploring the local trails nearby.
Stream Marine
Maritime Training provider set to expand into the online training space.
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