text:
Power Struggle Shakes Breakaway Republic In Eastern Ukraine As Armed Men Seize Luhansk
LUHANSK, Ukraine -- Armed men seized the capital of a Russia-backed separatist republic in eastern Ukraine amid a power struggle between two top officials.
Armed man in Luhansk, the capital of a Russia-backed separatist republic in eastern Ukraine
The takeover of Luhansk on Tuesday followed a decision by Igor Plotnitsky, the head of the breakaway Luhansk People's Republic, to fire interior minister Igor Kornet the night before.
Luhansk state television showed masked men with assault rifles and heavy machine guns blocking the entrances of administrative buildings and streets in the centre of Luhansk on Tuesday, reportedly on the orders of the interior ministry.
One of them wore the blue uniform the interior ministry's Berkut unit, a police force specialising in putting down riots.
The armed men had ignored Plotnitsky's command to leave, Russian independent newspaper Novaya Gazeta reported.
A video on Tuesday evening showed what appeared to be dozens of military vehicles entering Luhansk from the direction of the neighbouring Donetsk separatist republic, although a Donetsk official denied it was intervening.
In a video on Tuesday Kornet said he wanted to "dispel rumours" of his dismissal and said his forces had captured Ukrainian saboteurs who were attempting terrorist attacks in the republic.
He also claimed that Plotnitsky's chief of staff and the head of the security service had been implicated in a coup attempt last year and arrested on Plotnitsky's orders, along with the general director of the state television company.
But Plotnitsky later said in a statement on his website that Kornet had indeed been fired and the actions of interior ministry forces "crossed all acceptable lines".
He said the "attempts of certain people to remain in power" were futile and "will be completely neutralised in the near future".
The outcome of the power struggle remained unclear on Tuesday.
Novaya Gazeta reported that the republic's state security ministry, military headquarters and people's militia were "not participating in the conflict between Plotnitsky and Kornet".
Separatists seized control of much of the Luhansk and Donetsk regions in April 2014 following the establishment of a pro-Western government in Kiev and Russia's annexation of Crimea.
The ensuing conflict between the rebels, who have received military assistance from neighbouring Russia, and government forces has claimed more than 11,000 lives.
A ceasefire agreed in Minsk in 2015 has been regularly violated, and a Ukrainian soldier died in a mortar strike on Monday.
Several top separatist commanders have been assassinated since the start of the conflict.
Source: The Telegraph


Collins Booksellers - Shonishin: Japanese Pediatric Acupuncture by Stephen Birch, 9783131626127. Buy this book online.
Now in an expanded new edition, this user-friendly manual remains the foremost instructional reference for the application of Shonishin, or Japanese pediatric acupuncture. The book addresses the unique and often changing circumstances involved in the treatment of infants and children. It focuses on the crucial factors of patient comfort and dosage regulation throughout treatment by gently and painlessly pressing, tapping, scratching, rubbing, and stroking the skin without penetrating it. Stephen Birch, the world's leading authority in Japanese acupuncture and Shonishin, provides valuable clinical guidance and hands-on advice that can be easily integrated into everyday practice.
The book begins by presenting the underlying principles and treatment tools used in Shonishin, and then goes on to cover root and symptomatic approaches and techniques, followed by details on how to manage a wide range of specific problems and diseases. More than 75 case histories from around the world present various treatment ideas, methods, and results for the featured condition.


Aug 26, 2015 . Chirano Gold Mine is a combined underground and open pit gold mine in the Western Region of Ghana, owned by Red Back Mining up to.
Chirano Gold Mine is an underground and open pit gold mine in the Western Region of Ghana, within the Bibiani gold belt. It is 90% owned by Toronto based.
13 Jul 2015 . El caso de Chirano Gold Mines en la última década así lo confirma. . una vez que la agricultura ha cesado para abrirle camino a la actividad minera. . La producción de oro representa más del 90% del valor total de la producción de . se limitan en gran medida a contribuciones monetarias relativamente.
Minas de Oro is a municipality in the Honduran department of Comayagua. Contents. [hide]. 1 Geography; 2 Historical information; 3 Education. 3.1 City of.
Operations Americas West Africa Russia Projects & Exploration Reserves & Resources Corporate Responsibility Approach Workforce Environment.


text:
VA official apologizes to whistleblowers
FUBAR, News
James Tuchschmidt, a top official at the Veterans Health Administration
(AP Photo/Cliff Owen)
A top official at the Veterans Affairs Department says he is sorry that VA employees have suffered retaliation after making complaints about poor patient care, long wait times and other problems.
James Tuchschmidt, the No. 2 official at the Veterans Health Administration, the VA's health care arm, apologized on behalf of the department at a congressional hearing Tuesday night.
"I apologize to everyone whose voice has been stifled," Tuchschmidt said after listening to four VA employees testify for nearly three hours about VA actions to limit criticism and strike back against whistleblowers. "That's not what I stand for. I'm very disillusioned and sickened by all of this."
A federal investigative agency said Tuesday it was examining 67 claims of retaliation by VA supervisors against employees who filed whistleblower complaints — including 25 complaints filed since June 1, after a growing health care scandal involving long patient waits and falsified records at VA hospitals and clinics became public.
The independent Office of Special Counsel said 30 of the complaints about retaliation have passed the initial review stage and were being investigated further for corrective action and possible discipline against VA supervisors and other executives. The complaints were filed in 28 states at 45 separate facilities, Special Counsel Carolyn Lerner said.
Instead of using information provided by whistleblowers as an early warning system, the VA often "has ignored or attempted to minimize problems, allowing serious issues to fester and grow," Lerner told the House Veterans' Affairs Committee hearing. Worse, officials have retaliated against whistleblowers instead of investigating their complaints, she said.
Lerner said her office has been able to block disciplinary actions against several VA employees who reported wrongdoing, including one who reported a possible crime at a VA facility in New York.
The counsel's office also reversed a suspension for a VA employee in Hawaii who reported seeing an elderly patient being improperly restrained in a wheelchair. The whistleblower was granted full back pay and an unspecified monetary award, and the official who retaliated against the worker was suspended, Lerner said.
The VA said earlier Tuesday it was restructuring its Office of Medical Inspector following a scathing report by Lerner's agency last month.
Acting VA Secretary Sloan Gibson said the department would appoint an interim director of the medical inspector's office from outside the current office and was suspending the office's hotline immediately. All complaints would be referred to the VA's Office of Inspector General.
The head of the medical inspector's office retired June 30 following a report by the Office of Special Counsel saying that his office played down whistleblower complaints pointing to "a troubling pattern of deficient patient care" at VA facilities.
"Intimidation or retaliation — not just against whistleblowers, but against any employee who raises a hand to identify a problem, make a suggestion or report what may be a violation in law, policy or our core values — is absolutely unacceptable," Gibson said in a statement. "I will not tolerate it in our organization."
A doctor at the Phoenix veterans hospital, where dozens of veterans died while on waiting lists for appointments, said she was harassed and humiliated after complaining about problems at the hospital.
Dr. Katherine Mitchell said the hospital's emergency room was severely understaffed and could not keep up with "the dangerous flood of patients" there. Mitchell, a former co-director of the Phoenix VA hospital's ER, told the House committee that strokes, heart attacks, internal head bleeding and other serious medical problems were missed by staffers "overwhelmed by the glut of patients."
Her complaints about staffing problems were ignored, Mitchell said, and she was transferred, suspended and reprimanded.
Mitchell, a 16-year veteran at the Phoenix VA, now directs a program for Iraq and Afghanistan veterans at the hospital. She said problems she pointed out to supervisors put patients' lives at risk.
"It is a bitter irony that our VA cannot guarantee high-quality health care in the middle of cosmopolitan Phoenix" to veterans who survived wars in Iraq, Afghanistan, Vietnam and Korea, she said.
Scott Davis, a program specialist at the VA's Health Eligibility Center in Atlanta, said he was placed on involuntary leave after reporting that officials were "wasting millions of dollars" on a direct mail marketing campaign to promote the health care overhaul signed by President Barack Obama. Davis also reported the possible purging and deletion of at least 10,000 veterans' health records at the Atlanta center. More records and documents could be deleted or manipulated to mask a major backlog and mismanagement, Davis said. Those records would be hard to identify because of computer-system integrity issues, he said.
Rep. Jeff Miller, R-Fla., chairman of the House veterans panel, praised Mitchell and other whistleblowers for coming forward, despite threats of retaliation that included involuntary transfers and suspensions.
"Unlike their supervisors, these whistleblowers have put the interests of veterans before their own," Miller said. "They understand that metrics and measurements mean nothing without personal responsibility."
Rather than push whistleblowers out, "it is time that VA embraces their integrity and recommits itself to accomplishing the promise of providing high-quality health care to veterans," Miller said.
Follow Matthew Daly on Twitter at https://twitter.com/MatthewDalyWDC
Copyright © 2013 Capitol Hill Blue
Copyright © 2013 The Associated Press. All rights

redpajama_set_name: RedPajamaCommonCrawl


Vigene's RCaMP products come ready-to-use, with a choice of promoter with or without Cre inducible (FLEx-ON) expression. AAV8 and AAV9 serotypes of AAV-GCaMP1 are ready to ship. Should you require a different serotype, please contact us.
● RCaMP is a genetically encoded calcium indicator (GECI) which was generated from a fusion of the red fluorescent protein (RFP), calmodulin, and M13, a peptide sequence from myosin light chain kinase.
Upon the binding of GECI to Ca2+ there is an induction of a change in fluorescence signal. It is this change in signal which allows for measuring the action potentials, and other receptor activation events, that trigger Ca2+ fluxes.
● Suitable for simultaneously monitoring activity in two distinct classes of cells.
● Applications include use in multicolor functional imaging for drug screening, imaging of cellular activity in cells and organisms already expressing GFP, or imaging with less autofluorescence than green GECIs and dyes.
● Provides new color channels for single-wavelength functional imaging.
● Minimal bleed through into green channel, unlike other biosensors.
● Compatible with optogenetic activation/silencing via tools such as channelrhodopsin-2, facilitating "read/write" optogenetics.
● T unable affinity under control of various promoters.
● Detection using standard optical and nano technologies.
1. Marvin JS, Borghuis BG, Tian L, et al. An optimized fluorescent probe for visualizing glutamate neurotransmission. Nature methods. 2013;10(2):162-170. doi:10.1038/nmeth.2333.


Lined tulle ballerina style skirt.
3 layers of tulle plus underskirt.
Self covered button to fasten at the back at the top of the zip.
Fabric content: Shell- 100% Nylon, Waistband- 100 % Polyester, Lining- 100% Polyester.


San Francisco, CA (UroToday.com) Silke Gillessen, MD presented a study comparing two different dosing frequencies of Denusomab in patients with castration-resistant prostate cancer, and evaluating the rate of hypocalcemia in these two treatment options.
Chemotherapy following radium-223 dichloride treatment in ALSYMPCA.
BACKGROUND - Radium-223 prolongs overall survival in patients with castration-resistant prostate cancer (CRPC) and symptomatic bone metastases, regardless of prior docetaxel. Whether or not chemotherapy can be safely administered following radium-223 treatment is of clinical importance.
San Francisco, CA (UroToday.com) -- A team of researchers led by Duke Cancer Institute scientists Steven Patierno, Ph.D.; Daniel George, MD; Jennifer Freedman, Ph.D.; Jiaoti Huang, MD, Ph.D. and Amanda Hargrove, Ph.D. have been awarded a Movember Foundation-Prostate Cancer Foundation Challenge Award. The project includes a number of key co-investigators including Terry Hyslop, PhD (Biostatistics), Michael Kelley MD and Megan McNamara MD (key clinical oncology collaborators at the Durham Veterans Administration Hospital), James Abbruzzese, MD (DCI Associate Director for Clinical Research) and Hailiang Hu, PhD (senior scientist in Pathology). Muthana Al Abo, Ph.D., MD, joins the teams as a PCF Young Investigator. The $1 million award will support a two-year project investigating targeting RNA splicing for therapeutic application in race-related aggressive and lethal prostate cancer in African American and Caucasian patients, including Veterans.
Munich, Germany (UroToday.com) As has been the trend in management of advanced solid malignancies, there has been increasing interest in combining proven therapies to identify synergistic effect – survival benefit greater than any one drug alone could provide. This is particularly useful if the mechanism of action of these combined agents targets different pathways.
Munich, Germany (UroToday.com) Radium-223 is an alpha emitter which selectively treats bone metastases with alpha radiation1. In a recent GU ASCO oral presentation, a radium-223 pharmacodynamic study demonstrated that higher gamma emission is found in deep tumor containing regions of bone biopsies, compared with superficial regions, supporting the presumed mechanism of radium-2232.
Prostate cancer is the most common malignancy among US men, with an estimated annual incidence of 180,890, accounting for one in five new cancer cases in men . The second-most common cause of cancer death in US men, prostate cancer is expected to claim the lives of 26,120 men in this country in 2016 . For men with castration-resistant prostate cancer (CRPC), median survival ranges from nine to 34 months, depending upon numerous factors, including but not limited to, the presence of metastases, the location and volume of metastases, the presence of co-morbidities, the degree of acknowledged and interrogated symptomatology, etc. .
Prostate cancer exhibits a wide spectrum of disease behaviour. Despite the majority of cases presenting with relatively indolent biologic behaviour, prostate cancer remains the second leading cause of cancer-related death in the United States, behind only lung cancer.1 With current treatment paradigms, nearly all patients who die of prostate cancer first receive androgen-deprivation therapy and then progress to castrate-resistant prostate cancer.
There is a large spectrum of prostate cancer progression. For patients who are initially diagnosed with a clinically-localized disease, such a pathway is highlighted in the following diagram. For patients who present with de novo metastatic disease, they join this algorithm at "development of metastatic CSPC".
The clinical approach to patients with metastatic castrate-resistant prostate cancer (mCRPC) depends, in general terms, on three factors: whether the patient is symptomatic from their disease, the patient's performance status, and previous therapies which the patient may have received. These factors have been used to guide treatment recommendations in the guidelines from many medical/urologic societies. The definition of "symptomatic" prostate cancer is somewhat imprecise. However, most consider that patients who require only acetaminophen or non-steroidal anti-inflammatory drugs (NSAIDs) to be minimally symptomatic while those who require regular narcotic medications for pain that is attributable to documented metastasis are deemed symptomatic.
Advanced androgen axis targeting agents (such as abiraterone and enzalutamide) and chemotherapeutics (such as docetaxel) is increasingly used earlier in the disease process, including in de novo metastatic castrate-sensitive prostate cancer and in non-metastatic castrate resistant prostate. While there is some evidence that re-challenge with docetaxel may provide benefit in patients who previously demonstrate docetaxel response, 2, 3 the use of advanced androgen axis targeting agents and docetaxel earlier in the disease trajectory may preclude their use at the development of mCRPC. Acknowledging the changes this utilization has on the treatment of mCRPC, this article will focus on guideline-recommended treatment options.
As the androgen axis continues to be important in patients who have developed castration resistance, ongoing continuous treatment with androgen-deprivation therapy is recommended.4 Historically, a number of secondary hormonal manoeuvre have been employed. However, routine use of these preceded the availability of therapies with proven survival benefits. As no secondary hormonal manoeuvre has been shown to prolong survival, they are not widely recommended. However, there is evidence that, for patients who are currently receiving LHRH agonist or antagonist monotherapy, the addition of androgen receptor antagonists and resulting total androgen blockade is associated with short-term PSA-responses. Conversely, for patients who are currently receiving total androgen blockage, anti-androgen withdrawal is recommended as some patients may experience an antiandrogen withdrawal response.
For symptomatic patients with poor performance status who have not previously received docetaxel, there is a relative paucity of direct evidence to inform treatment choices as most patients with poor performance status are excluded from clinical trials. However, guidelines typically extrapolate from studies in patients with better performance status to guide therapy in these patients.5 Aggressive prostate cancer treatment may especially be warranted where the functional impairments resulting in poor performance status are directly attributable to prostate cancer. In contrast, patients with poor performance status as a result of other medical conditions have less to gain from aggressive prostate cancer therapy. Considering these factors, individual, tailored therapy is warranted with a thorough discussion of potential risks and benefits of therapy. The AUA guidelines currently recommend either abiraterone plus prednisone or enzalutamide for these patients.5 For patients with poor performance status that is attributable to their disease burden, docetaxel or mitoxantrone may be offered whereas, when the poor performance status is related to bony metastatic disease, radium-223 is a recommended option. For patients unable or unwilling to receive standard therapies, ketoconazole with steroids or radionuclide therapy remain options though these have not demonstrated survival benefit5. In contrast, the CUA guidelines do not stratify by performance status and recommend docetaxel with abiraterone plus prednisone or enzalutamide as alternatives for patients who cannot receive or refuse docetaxel and radium-223 as an alternative for patients who have bony pain related to their metastases and no visceral disease.4 The AUA guideline is clear that patients who are symptomatic and have poor performance status should not be offered sipuleucel-T.
Among patients with mCRPC who have previously received docetaxel-based chemotherapy, treatment options may again be stratified by performance status. There are 4 agents with a proven survival benefit in this population: abiraterone plus prednisone; enzalutamide; cabazitaxel; and radium-223. Given that this is a relatively advanced disease state and these treatments remain non-curative and yet have a significant potential burden of toxicity, care should be taken to provide prostate cancer treatments which preserve these patients' excellent quality of life. It is also at this time that sequencing of agents becomes particularly relevant as many patients will have received an advanced androgen axis targeting agent (abiraterone or enzalutamide) prior to receiving docetaxel and will now be on their third line of mCRPC treatment.
In 2011, the COU-AA-301 trial demonstrated that abiraterone plus prednisone could improve overall survival approximately 4 months for patients with advanced mCRPC following docetaxel chemotherapy.12 Subsequently, in 2012, the AFFIRM trial demonstrated similar results for enzalutamide in this patient population.13 TROPIC tested cabazitaxel versus mitoxantrone, each with prednisone, in patients who had progressed following docetaxel for mCRPC and demonstrated an improvement of approximately 2.5 months overall survival for patients receiving cabazitaxel.14 As discussed previously among patients who had not yet received docetaxel, ALSYMPCA demonstrated an improvement in both survival and skeletal-related events for patients receiving radium-223.11 In addition to these agents, docetaxel re-challenge is suggested for patients who discontinued therapy due to reversible toxicity. The AUA guidelines again offer ketoconazole plus steroids for patients who are unable or unwilling to take other agents.
In patients with advanced mCRPC who are symptomatic and have poor performance status following previous docetaxel chemotherapy, symptom management is strongly advocated in keeping with the American Society for Clinical Oncology's guidance regarding the treatment of patients with advanced solid tumors. Aggressive treatment at this time may lead to unnecessary cost and toxicity, may delay access to the end of life care, and is unlikely to provide meaningful benefit. Therefore, palliative care is prioritized. Abiraterone plus prednisone, enzalutamide, ketoconazole plus steroid or radionuclide therapy are offered within the AUA guidelines5 but there is no strong data to support the use of these agents in this patient population.
Apart from specific mCRPC medication, bone health remains important in all patients with advanced prostate cancer due to a confluence of risk factors: age-related declines in bone mineral density, the deleterious effects of androgen-deprivation therapy on bones15 (even among patients with localized prostate cancer16), and the involvement of bony metastatic disease. Therefore, calcium and vitamin D are recommended for all patients with mCRPC. In addition, a bone-targeting agent, either denosumab or zoledronic acid, is recommended. These agents have been shown to decrease disease-related skeletal events though, unlike radium-223, they have not been found to improve survival. The timing of initiation of bone-targeted agents is somewhat unclear as there is evidence that the risk of significant toxicity (particularly, osteonecrosis of the jaw) increases substantially after 2 years of therapy17 and may patients with mCRPC will be expected to live longer than this.
Additionally, the symptomatic benefit of palliative radiotherapy should not be underestimated, and this should be offered where it is deemed clinically appropriate.
Despite the survival benefits of many agents in metastatic castrate-resistant prostate cancer, these treatments remain non-curative. Therefore, consideration for enrollment in ongoing clinical trials should be considered for all eligible patients.
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin 2018; 68(1):7-30.
Thomas C, Brandt MP, Baldauf S, et al. Docetaxel-rechallenge in castration-resistant prostate cancer: defining clinical factors for successful treatment response and improvement in overall survival. Int Urol Nephrol 2018; 50(10):1821-1827.
Oudard S, Kramer G, Caffo O, et al. Docetaxel rechallenge after an initial good response in patients with metastatic castration-resistant prostate cancer. BJU Int 2015; 115(5):744-52.
Saad F, Chi KN, Finelli A, et al. The 2015 CUA-CUOG Guidelines for the management of castration-resistant prostate cancer (CRPC). Can Urol Assoc J 2015; 9(3-4):90-6.
Lowrance WT, Murad MH, Oh WK, et al. Castration-Resistant Prostate Cancer: AUA Guideline Amendment 2018. J Urol 2018; 200(6):1264-1272.
Tannock IF, de Wit R, Berry WR, et al. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med 2004; 351(15):1502-12.
Ryan CJ, Smith MR, de Bono JS, et al. Abiraterone in metastatic prostate cancer without previous chemotherapy. N Engl J Med 2013; 368(2):138-48.
Beer TM, Armstrong AJ, Rathkopf DE, et al. Enzalutamide in metastatic prostate cancer before chemotherapy. N Engl J Med 2014; 371(5):424-33.
Kantoff PW, Higano CS, Shore ND, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med 2010; 363(5):411-22.
Oudard S, Fizazi K, Sengelov L, et al. Cabazitaxel Versus Docetaxel As First-Line Therapy for Patients With Metastatic Castration-Resistant Prostate Cancer: A Randomized Phase III Trial-FIRSTANA. J Clin Oncol 2017:JCO2016721068.
Parker C, Nilsson S, Heinrich D, et al. Alpha emitter radium-223 and survival in metastatic prostate cancer. N Engl J Med 2013; 369(3):213-23.
de Bono JS, Logothetis CJ, Molina A, et al. Abiraterone and increased survival in metastatic prostate cancer. N Engl J Med 2011; 364(21):1995-2005.
Scher HI, Fizazi K, Saad F, et al. Increased survival with enzalutamide in prostate cancer after chemotherapy. N Engl J Med 2012; 367(13):1187-97.
de Bono JS, Oudard S, Ozguroglu M, et al. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial. Lancet 2010; 376(9747):1147-54.
Shahinian VB, Kuo YF, Freeman JL, et al. Risk of fracture after androgen deprivation for prostate cancer. N Engl J Med 2005; 352(2):154-64.
Wallis CJ, Mahar AL, Satkunasivam R, et al. Cardiovascular and Skeletal-Related Events Following Localised Prostate Cancer Treatment: Role of Surgery, Radiotherapy and Androgen-Deprivation. Urology 2016; 97:145-152.
Barasch A, Cunha-Cruz J, Curro FA, et al. Risk factors for osteonecrosis of the jaws: a case-control study from the CONDOR dental PBRN. J Dent Res 2011; 90(4):439-44.
Mateo J, Carreira S, Sandhu S, et al. DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer. N Engl J Med 2015; 373(18):1697-708.
Clarke N, Wiechno P, Alekseev B, et al. Olaparib combined with abiraterone in patients with metastatic castration-resistant prostate cancer: a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Oncol 2018; 19(7):975-986.
Gulley JL, Borre M, Vogelzang NJ, et al. Phase III Trial of PROSTVAC in Asymptomatic or Minimally Symptomatic Metastatic Castration-Resistant Prostate Cancer. J Clin Oncol 2019:JCO1802031.
Radium-223 is a novel alpha emitting radiopharmaceutical with bone tropism, now FDA approved for men with symptomatic bone-metastatic castration-resistant prostate cancer. Approval was based on the survival benefit observed in the phase 3 ALSYMPCA trial over best supportive care, which included oral steroids or hormonal therapies, bone anti-resorptive therapy, and palliative radiation.
Health Economics and Radium-223 (Xofigo®) in the Treatment of Metastatic Castration-Resistant Prostate Cancer (mCRPC): A Case History and a Systematic Review of the Literature.
OBJECTIVE - Prostate cancer (PC) is the most common cancer in Western countries. Recent advances in the treatment of metastatic castration resistant prostate cancer (mCRPC) have caused significant pressure on health care budgets.
BACKGROUND: The imaging response to radium-223 therapy is at present poorly described. We aimed to describe the imaging response to radium-223 treatment.
METHODS: We retrospectively evaluated the computed tomography (CT) and bone scintigraphy response of metastatic castration-resistant prostate cancer (CRPC) patients treated with radium-223, in eight centers in three countries.
Scientists at The University of Texas MD Anderson Cancer Center have engineered a system allowing microscopic monitoring and imaging of cancer that has spread to the bone in mice so they can better understand and develop treatment for bone metastasis in humans.
Patient-reported quality of life analysis of radium-223 dichloride from the phase 3 ALSYMPCA study.
BACKGROUND - Radium-223 dichloride (radium-223), a first-in-class alpha-emitting radiopharmaceutical, is recommended in both pre- and post-docetaxel settings in patients with castration-resistant prostate cancer (CRPC) and symptomatic bone metastases based on overall survival benefit demonstrated in the phase 3 ALSYMPCA study.
Radium-223 and concomitant therapies in patients with metastatic castration-resistant prostate cancer: an international, early access, open-label, single-arm phase 3b trial.
In the previously reported ALSYMPCA trial in patients with castration-resistant prostate cancer and symptomatic bone metastases, overall survival was significantly longer in patients treated with radium-223 dichloride (radium-223) than in patients treated with placebo.
Radium-223 for primary bone metastases in patients with hormone-sensitive prostate cancer after radical prostatectomy.
Radium-223 dichloride (Ra-223) is the first bone-targeting agent showing improvement in overall survival in patients with castration-resistant prostate cancer (CRPC) and bone metastases. We aimed to assess feasibility of Ra-223 treatment in patients with metastatic hormone-sensitive prostate cancer (mHSPC).
Radium-223 in Heavily Pretreated Metastatic Castrate-Resistant Prostate Cancer.
This article  is a comprehensive analysis of 10 prostate cancer patients who received Ra-223-treatments. These patients were imaged with multiple quantitative PET methods according to our own algorithm , including fluoro-18-choline-PET and sodium fluoride-18 PET. These patients were additionally treated with multidisciplinary methods, including other radiation therapies. We recently reported an overall survival of 8.4 years in 46 patients of high-risk T3-4NXM1 primarily metastatic prostate cancer .
IMPORTANCE: Targeted alpha therapy attempts to deliver systemic radiation selectively to cancer cells while minimizing systemic toxic effects and may lead to additional treatment options for many cancer types.
Treatment landscape of metastatic prostate cancer: the role of radium-223.
The landscape of metastatic prostate cancer has changed recently with the availability of six new molecules showing an overall survival benefit. The development of compounds able to decrease the rate of complications from bone metastasis has also led to improvements in overall morbidity associated with this disease.
Even when symptoms, such as pain, impose significant impacts on their daily lives, many men with advanced prostate cancer do not report the symptoms to their doctors, according to an international survey of both patients and their caregivers to explore this issue. Symptoms may go unrecognized as being associated with cancer, or men deliberately choose not to speak about them with their doctors. As a result, they may not receive interventions that could ease the discomfort.


Tomlin showed how to make an opening.
around giving the sense of her territory.
These are well honed ideas for presentations.
and level and with hands exposed and open.
greeting by shifting carried items.
hands exposed rather than in their pockets.
contact and fixation become important.
the person to understand that you wish to interact.
presentation of yourself to the other person.


I already have a battery-operated smoke detector, so why would I need one installed as part of my security alarm?
Since you own a smoke detector, you obviously realize what an important safety measure this device is. That's good. Smoke detectors are highly effective in preventing loss of life and property.
I've heard so much about these "wireless" security devices. Do they really work & how long do the batteries last?
Yes on both counts! Technological breakthroughs have led to the development of wireless electronic security products, and their effectiveness has been proven time and again over the years in millions of installations.
"Acoustic" glassbreak sensors, usually mounted on ceilings or walls, work by "listening" for the sound of breaking glass in a window. "Shock" glassbreak detectors are mounted on the window and "feel" the shock of breaking glass.
Absolutely not. Recent innovations in security technology have resulted in the creation of "pet immune" motion detectors-allowing dog and cat lovers to enjoy the same level of protection they would receive with a standard PIR.


This non-spicy seasoning salt saves the time and effort of pulling several spice jars out of your pantry--they're all right there in the spice jar. It goes on almost everything and doesn't have any specific spice or any herb that ties it to a particular dish or ethnic cuisine.
From Terri - For daily cooking, I'm always reaching for the same spices: salt, pepper, onion and garlic powder, and paprika. I determined the proportions I generally used and came up with this seasoning salt to use every day.
The recipe is easily halved.
This is an everyday seasoning that goes with almost everything savory--no spices or herbs to slant it toward one type of cuisine or another. I use this so often I make it up in large batches. As with all seasoning and spice blends, you may reduce the amount of pepper if you prefer a milder flavor.
This everyday seasoning salt can also be used as a flavor enhancer on already cooked food. Sprinkle some on freshly cooked vegetables, a steak, rice, salad, cottage cheese or whatever you choose. The uses are endless – use it before, during, and after cooking to add great flavor with little effort!
As with all of the seasoning blends, I will write about (this is the first of six), these do not contain any "anti-caking" agents so the seasonings may tend to stick together. To help prevent this keep the spices in a tightly capped jar or zip-style bag in a cool, dark place, or store in the refrigerator. Never keep your spices (or herbs) on a shelf above your stove, or close to your stove. The heat and moisture will cause the flavor to dissipate, and spices will tend to "clump" even quicker.
While a cool, dark pantry will help keep the seasonings free flowing and fresh, if clumping does occur, simply shake the seasoning aggressively and/or bang container on the countertop. For those times when simply shaking the container does not work, remove the cap and use a spoon or fork to stir and break up the seasoning. Warm, humid temperatures tend to accelerate the "clumping" effect of the all-natural ingredients.
Make up this spice blend in large batches, transfer to attractive jars and place jars in a basket, and give as gifts. So easy, inexpensive, and always appreciated. I will be presenting a total of six different spice blends for about.com. Making up all the blends, and putting one of each in a basket with a label makes a wonderful gift that your friends will enjoy all year. And this "gourmet variety" of spices will cost less that a bottle of wine or a bunch of flowers! The six blends will all be on about.com in plenty of time for holiday gift-making.


But mortal mind without immortal spirit cannot survive. The mind of man is mortal; only the bestowed spirit is immortal. Survival is dependent on spiritualization by the ministry of the Adjuster--on the birth and evolution of the immortal soul; at least, there must not have developed an antagonism towards the Adjuster's mission of effecting the spiritual transformation of the material mind.


text:
La Liga Argentina de Voleibol 2013-2014 si è svolta dal 30 novembre 2013 al 19 aprile 2014: al torneo hanno partecipato 11 squadre di club argentine e la vittoria finale è andata per la quarta volta consecutiva all'UPCN Vóley Club.

Regolamento

Formula
Le 11 formazioni partecipanti danno vita a una regular season con gare di andata e ritorno, composta da 12 weekend, nei quali si disputano due incontri, per un totale di 20 incontri:
Le prime otto classificate accedono ai play-off scudetto, disputati al meglio delle tre gare nei quarti di finale e al meglio delle cinque gare nelle semifinali e in finale.

Criteri di classifica
Se il risultato finale è stato di 3-0 o 3-1 sono stati assegnati 3 punti alla squadra vincente e 0 a quella sconfitta, se il risultato finale è stato di 3-2 sono stati assegnati 2 punti alla squadra vincente e 1 a quella sconfitta.

L'ordine del posizionamento in classifica è stato definito in base a:
Punti;
Numero di partite vinte;
Ratio dei set vinti/persi;
Ratio dei punti realizzati/subiti.

Squadre partecipanti
Al campionato di Liga Argentina de Voleibol 2013-2014 partecipano 11 club. Due club aventi diritto, il  e l', non si si sono iscritti; il neonato  ha invece acquistato il diritto di partecipazione, mentre le due neopromosse sono il  e l'.

Campionato

Regular season

Risultati

Classifica

Play-off

Quarti di finale

Semifinali

Finali

Premi individuali

Classifica finale

Collegamenti esterni

Pallavolo nel 2013
Pallavolo nel 2014
Liga Argentina de Voleibol

redpajama_set_name: RedPajamaWikipedia


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Drop everything: Apple MacBook Air M1 Cyber Monday deal is the cheapest we've ever seen
This MacBook Air M1 deal may be the best Cyber Monday deal we've ever seen, with Amazon cutting the price of the base model to just £829 - the cheapest we've ever seen it.
In the US, we've seen a similarly low deal for the M1 MacBook Air for just $734.99, though this is with a smaller 128GB SSD (the UK model has double at 256GB). The US model is also refurbished.
(Not in the UK or US? Scroll down for deals in your region).
The MacBook Air (M1, 2020) has been our pick for the best laptop in the world since it launched two years ago, only having recently been replaced with the newer M2 model (which is also more expensive).
We've seen a couple of MacBook Air M1 deals quickly go out of stock, and none of them are as cheap as this one, and you're not going to find a laptop this good for this cheap anywhere else, as far as we're concerned. Stock is selling out fast, however!
Today's best MacBook Air deals
MacBook Air (M1, 2020): was £999 now £829 at Amazon
Stock for the MacBook Air M1 is now more stable and we're seeing some better discounts. This configuration offers 8GB RAM and a 256GB SSD, which is a solid spec for all your computing needs. Today's price is the best we've ever seen and stock is selling out fast.View Deal
MacBook Air (M1, 2020): was £999 now £879 at Very
Stock for the MacBook Air M1 is now more stable and we're seeing some better discounts as we head towards Cyber Monday. This configuration offers 8GB RAM and a 256GB SSD, which is a solid spec for all your computing needs. Today's price is the best we've seen in months, so it's a great time to buy if you don't want to wait for any potentially better discounts in November.View Deal
MacBook Air (M1, 2020): was $999 now $734.99 at Amazon
With this MacBook Air deal, you're getting the best laptop in the world for just $734.99, which is one of the best prices we've seen. If you want a thin and light laptop, this is the one to get, but unlike the UK model, it comes with a smaller 128GB SSD and is refurbished.View Deal
More MacBook Air deals
No matter where you live, you'll find all the lowest prices for the MacBook Air from around the web right here, with offers available in your region.
More US Cyber Monday deals
Amazon: 50% off TVs, AirPods, clothing & toys
Apple AirPods Pro 2: down to $199 at Amazon
Best Buy: up to $700 off TVs, laptops & iPads
Cheap TVs: $79.99 smart TVs from Best Buy
Christmas trees: prices starting at $38.99
Dell: laptops from $299.99
Gifts ideas: 40% off holiday gifts from Amazon
Home Depot: 50% off tools & appliances
Lowe's: $750 off appliances, decor & tools
Macy's: coats, sweaters & boots from $10
Overstock: 70% off decor and furniture
Nectar: up to $500 off mattresses + free gifts
Nordstrom: 50% off UGG, Nike & North Face
Samsung: $2,500 off TVs & appliances
Sephora: 50% off makeup, perfume & gifts
Target: 45% off toys, TVs, Keurig & more
Toys: 50% off best-selling toys at Walmart
Ulta: up to 50% off makeup, hair & perfume
Verizon: get the iPhone 14 Pro for free
Walmart: 60% off toys, TVs, vacuums & laptops
Wayfair: up to 80% off sitewide, + free shipping
More UK Cyber Monday deals
Amazon: up to 60% off TVs, laptops, and more
Adidas: up to 50% off trainers and clothing
AO: deals on appliances, headphones and TVs
Argos: up to 1/3 off toys and big TV deals
Boots: half-price fragrances and make-up
Box: up to £1,000 off TVs, laptops and PCs
Currys: 40% off TVs, laptops and vacuums
Dell: up to 45% off laptops and desktops
Dyson: save £100 on the Dyson Cyclone V10
EE: up to £300 gift card with select phones
Game: PlayStation and Xbox games from £4.99
John Lewis: up to £400 off TVs and appliances
Lego: 25% off dozens of sets
Ninja: save up to £90 on air fryers and pans
Peloton: up to £500 off
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Shark: up to £220 off cordless vacuum cleaners
Very: offers on TVs, Lego and fashion
Virgin: broadband deals from £25 per month
Wayfair: furniture, lighting and mattress deals


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Red Banyan Successfully Guides Nonprofit Through Critical Organizational Shift
A respected nonprofit organization was facing a potentially destructive crisis when its long-time leader was forced to step down due to a variety of circumstances beyond his control. For legal reasons, the individual could not provide details, but needed to effectively communicate his resignation to the board of directors, the members of the organization and the general public. Doing so required the delicate consideration of many factors to successfully navigate the risks associated with the announcement.
At this critical point in its history, the nonprofit required a public relations agency that it could rely upon and trust for sound guidance. Red Banyan was called in during this difficult time to help the director navigate the sensitive and high-stakes situation.
Realizing that concerns might arise as to how the organization would fair without his ongoing leadership, it was necessary for the retiring executive to reassure members that the nonprofit and its mission would continue after his resignation. Negative attention from the media also needed to be minimized to preserve the director's privacy and to maintain the organization's forward momentum.
Red Banyan developed a comprehensive crisis and corporate communications plan to steer the organization through these challenging circumstances. The expert team worked closely with the resigning leader to create an effective public relations strategy for rolling out the news. Key messaging points and a detailed media strategy were mapped out in advance of the announcement. Red Banyan remained readily available as press counsel and took steps to minimize negative repercussions in all instances where complications arose.
The transition announcement went smoothly and did not produce any significant degree of blowback from inside or outside the organization. Due to Red Banyan's strategic guidance and proactive counsel, the director's resignation did not become a prominent media story, nor did it generate panic within the nonprofit. Business and personal relationships emerged unscathed and the former executive to this day remains well-liked and well-respected by the board of directors and the members. Despite facing what could have been a substantial setback (or even the dissolution of the organization if not handled properly), the nonprofit's work with Red Banyan has enabled it to continue forging ahead.


L'Agefi - Reduced political risk in Europe and the US Federal Reserve's relative openness about its intentions have clarified the outlook for the bond markets.
The political uncertainty facing the financial markets in the spring has now largely faded. The outcome of France's presidential and parliamentary elections has been welcomed by the markets, while the UK's snap election has had no impact, with the Brexit process continuing as expected. In addition, the rhetoric from European leaders has turned positive again, and Emmanuel Macron's victory in France is giving a new lease of life to the Franco-German partnership. Although the situation in Italy could still create volatility, peak political uncertainty seems to be firmly behind us, and the situation has become much calmer in the bond markets.
That is especially true given that monetary-policy adjustments by western central banks are also unlikely to destabilise the markets. In the USA, the Fed is gradually raising its official interest rates. In Europe, the ECB has announced that it will not be cutting policy rates any further, and it has reduced the pace of its bond purchases. As a result, the prospect of a sharp increase in interest rates causing a bond crash – which many investors still feared in the first half of 2017 – seems to have been ruled out, and recent communication by the Fed and ECB has been broadly in line with market expectations.
The Fed's plan to reduce its balance sheet has not come as a surprise to traders, although it was mentioned a little earlier than expected. Measures to reduce the Fed's balance sheet are highly likely to start in September. The next Fed funds rate hike, meanwhile, could be announced in December. However, the consensus forecast of three rate hikes in 2018 looks overdone. The pragmatic approach would be to wait and see what the FOMC does in its next few meetings before forecasting how quickly monetary policy will return to normal in 2018.
Although the situation in the bond market has become clearer, investors should not ignore interest-rate risk, because bond yields are still extremely low, particularly in Europe. In the circumstances, active management is vital to protect portfolios against yields rising – even gradually – in the wake of US movements.
Investors need to look beyond the "euro aggregate" universe to find alternatives offering greater protection. The current situation requires a holistic, unconstrained approach to the bond markets.
As in the last few months, we have several preferred investment themes. US credit remains attractively valued compared with its European equivalent. It is true that renewed uncertainty about the direction of oil prices could prevent US corporate bond prices from rallying. Oil prices are currently moving within a range of $42-55, similar to levels seen in 2015 and 2016. However, today's situation is different: back then, the ISM index was at 48 and there was concern that the USA would fall back into recession, putting significant downward pressure on oil prices. Today, the health of the US economy is no longer in question. The current low level of oil prices is due solely to the inability of oil-producing countries to agree to adjust production.
Similarly, the US high-yield segment, where CDS spreads are currently 70 basis points higher than their 5-year average on a carry and roll-down basis, is still offering value. Investors can optimise their income profile by investing in the US high-yield segment via derivatives like CDSs. High-yield CDSs remain cheap relative to the prices of their underlying bonds.
Finally, subordinated bank debt also remains attractive, provided that investments are selected carefully. The recent events with Banco Popolare and the Veneto region banks means that investors should focus on systemically important banks, to the extent that these larger institutions have already cleaned up their balance sheets and restructured their businesses. By taking a flexible approach to the bond markets, these investment ideas help to reduce portfolio risk.


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Universities Contributing to Knowledge Bank of Energy in Strata
With countless new energy technologies emerging, it is important to independently research the true benefits and specifically the relevance of these technologies to strata. What better way to do that, than to tap into vast resources contained within our universities.
For the last couple of years, Wattblock has been working closely with the University of NSW, Griffith University, the University of Queensland and Queensland University of Technology, to fill these knowledge gaps as they emerge.
Thanks to Griffith University, Strata managers can now register buildings in the City of Sydney and in Queensland for a fully funded electric vehicle recharge assessment. Read more about the program here.
Griffith University Project Supervisor Dr Prasad Kaparaju
Questions like: How can solar power be split within apartments? What are the best type of batteries for strata? What is the best strata hot water system? What is the best use of strata roof space, solar hot water or solar PV? How will the increase of electric vehicles impact strata? Through working with these institutions, we have been able to better understand these issues and opportunities, and many more.
A number of state and local Government programs are promoting closer ties between companies and universities. In 2016 Wattblock was award a 'Knowledge Transfer Partnership' grant by the Queensland Government. The grant partnered Wattblock with Griffith University, who supervised a recent graduate of the University of Queensland, to develop a suite of energy efficiency calculators for Wattblock.
Many universities require their students complete an internship as a course requirement. The internships aim to offer students real-life work experience, while completing an academically supervised research paper.
The relationships are a "win-win". The students receive real-life work experience, and are given the opportunity to work on new and real problems as new technologies and opportunities emerge. The universities are grateful for the opportunities for their students, and provide support and advice as required. Wattblock get the benefit of custom research into areas of interest and relevance.
As semester 2, 2017 wraps up, thanks to Griffith's University Industry Affiliates Program and Enoch Kwei and Kulima Panapa, we have another two relevant research papers. Enoch's paper examined what is the better use of limited strata roof space, Solar PV or Solar thermal hot water. Kulima's paper looks at the issues installation of electric vehicle recharging can create for strata buildings.
A number of our strata energy focused research papers can be found here.
For further reading about university engagement try Strata Attracts Top University Talent. For further reading about the current electric vehicle recharge project, read more here.
Scott Witheridge


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Loren is a flawlessly sexy, slim brunette European escort who provides exclusive VIP outcalls throughout exclusive London and outer London regions. She has an air of superior sophistication that follows her around everywhere. This naturally busty 34D luxury companion has the most supremely slim figure. This flirtatious and spontaneously fun Polish beauty provides the most luxurious companionship only GFE (girlfriend experience) outcalls. Loren is an elegant lady who is accustomed to attending the most luxurious events, parties, functions, and VIP dinners. You will be immediately captivated by her glistening chocolate brown eyes and naughty, radiant smile. Loren always loves to dress with style, elegance, and sexiness. Discretion is everything when it comes to the outcall escort services she provides. Loren is a very intelligent lady who is well travelled. She has a very confident personality and even though she is exceptionally beautiful she is still a very down to earth person. Book a private VIP outcall experience with Loren today and encounter the most fun-loving and adventurous date imaginable.
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The phrase laissez- faire is part of a larger French phrase and translates to " let ( it/ them) do", but in this context usually means " let go".


text:
Emraan & Ajay Devgn Promote 'Once Upon A Time In Mumbaai'
Emraan Hashmi Promote 'Once Upon A Time In Mumbaai'
Emraan Hashmi & Ajay Devgn Promote 'Once Upon A Time In Mumbaai'
Ajay Devgn & Emraan Hashmi Promote 'Once Upon A Time In Mumbaai'
Ajay Devgn Promote 'Once Upon A Time In Mumbaai'
Ajay Devgn
Cine Max
Once Upon A Time In Mumbaai
Once Upon A Time In Mumbai
Page 3 Pics
SHOAIB July 21, 2010 at 17:49
I LOVE AJAY DEVGAN IAM SHOAIN FROM PAK I HOPE ONCE UPON A TIME IN MUMBAI HAS A SUPER DUPER SUCESS,LOVE U AJAY.
ASIF July 21, 2010 at 17:52
rock ajay.u one of the top actor in bollywood iam biggest fan of u. asif qadir from pakistan
shahzad July 21, 2010 at 17:55
i love u ajay.brilliant actor.once upon a time will be blockbuster. shahzad from pakistan
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You have to use some of these essay elements only when a specific format is required. E.g., there is no need to prepare an abstract in MLA style. Also, a good MLA paper does not require title or cover page. Well, it is complicated to get the better structure and the main idea from the first time, so check and try these effective tips below.
You might get stuck with the particular sentence or introduction without having the best essay sample in front of you. Clear "A"-level essay will help you to understand the specific topic, general structure, or any other thing related to a writing activity. Use online samples for example of a climat change essay, to develop your unique approach to writing academic assignments. An excellent example may also offer you a better idea. Follow any student with satisfying performance to improve your writing skills. Change some approaches to writing an essay. It may be original word usage or specific sentence order. In any case, the information you provide should appear in a clear and logical manner. Your essay shouldn't look as the copy of one's work.
To do so, read articles on different disciplines. Use bullet point style list – it will serve as the primary source to get inspired. Try to read more than one article on the particular topic to get a better picture of the problem subject. A good source is the newspapers. Check magazines as well. Every article and every sentence may serve as a fresh idea for your further essay or research. Besides, professional writers can help you to understand how to write an engaging essay or article.
Become a 'word a day' email subscriber. Write down the most attractive topic or idea from your e-mail in a bullet point list. Refer to a dictionary whenever you don't know a word. Look for various literature pieces to learn new information and use it properly. Use a thesaurus. We often repeat words in our essays. To avoid this mistake, look for a better option. Learn the history of word formation. Prefixes, suffixes and roots may improve and diversify your language. Use them too.
It would look like an overview of your essay. Tell people around about your topic to see their reaction. You will understand which idea is worth describing and what you need to avoid. Write pros and cons of your chosen point. Use arguments. You don't want to make it longer than an introduction or any other separate paragraph. Explain why your idea is better than others like you have to sell it.
Avoid sophisticated sentence structures. Make every paragraph, especially the introduction and the conclusion, easy to read. Write the story in a way that reader may want to read it by utilizing a variety of interesting syntax. Read your old essay and pay attention to each sentence. Make in-depth analysis. Is its structure okay? What is the most important thing you like about it? Yes, you can recall how to write a good essay from your own "A" graded work. Use its better sides.
Use online tools to revise The first step is to write your essay, but it may fail without proper revision. That is a good reason to check every paragraph and reference page. Focus on introduction and conclusion. You may improve the text easily: use online grammar and plagiarism check software. Look for any mistake carefully: you can still come up with a better written essay when proofreading and editing each sentence and overall structure.


Great little song! It is between Rock, Pop, Country! Watch the video!
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One of the bands that keep on going after all the years of hits! Watch this live video!
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This group keeps on ROCKING 'N ROLLING ALL THE TIME! I think we will see them 20 years from now with another 30 more albums! Watch the video!
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The Library of Congress holds several collections relating to the Federal Music Project, Federal Theatre Project, and Federal Writer's Project.
The Federal Music Project Collection and Federal Theatre Project Collection are in the custody of the Library's Music Division. You may read more detailed descriptions of the collections here: Federal Music Collection Finding Aid; Federal Theatre Project Finding Aid. You may contact staff in the Performing Arts Reading Room directly with any questions about the collections.
The Library's American Folklife Center also holds sound recordings of WPA life histories, stories, songs, and ballads. Contact American Folklife Center staff here.
We hope this information is helpful. Best of luck in your research!


A romantic, feminine fragrance with with a hint of marine scent. Escape opens with camomile, apple, lychee, mandarine, rose, plum and peach, balanced by coriander and sandalwood. It was created in 1991. Here you can read our articleՎ Calvin Klein in step with timeՎ.
Secret Obsession by Calvin Klein is oriental floral fragrance for women.Top notes are exotic plum, nutmeg (mace) and Damascus Rose; middle notes are Egyptian jasmine, French orange blossom and seductive tuberose; base notes are cashmere woods, Madagascar vanilla, burnt amber and Australian sandalwood.
CK One Red Edition for Her is described as an addictive floral – fruity fragrance that offers a new kind of freshness. The composition opens with watermelon and violet accord leading to the floral heart and the base of patchouli, white amber and skin musk.
Eternity by Calvin Klein is a Aromatic Fougere fragrance for men. Eternity was launched in 1990. Top notes are lavender, mandarin orange, bergamot and lemon. Middle notes are coriander, lily, orange blossom, juniper berries, basil, jasmine, sage, lily-of-the-valley and geranium. Base notes are sandalwood, amber, musk, vetiver and brazilian rosewood.
CK Be is a unique tonic musk thats clean and fresh, with a simple blend of herbs, citruses and florals. Top: Lavender, Mint, Mandarin, Juniper. Heart: Grass, Magnolia, Orchid, Freesia. Base: Sandalwood, Amber, Musk, Cedar.


This year Belarusbank, a member of WSBI, celebrates its 95th anniversary. The oldest and largest commercial bank of Belarus is a leader of Belarusian banking industry and has recently started the implementation of the state programme that aims to increase financial literacy in the country. According to bank representatives, the main goal of this campaign is to introduce customers to new banking technologies and products.
In the first half of 2017 Belarusbank organised around 4000 seminars, presentations, round table discussions, extracurricular activities, courses, contests and interactive games where more than 150 000 people participated. Approximately one third of all activities took place in schools, colleges, universities and other educational institutions.
In order to continue the efforts of increasing financial literacy in the country, the National Bank of the Republic of Belarus has initiated the new action plan for 2019-2023. Government authorities and representatives of financial organisations are working together on the new plan which ensures that financial literacy in Belarus remains high on the agenda.
Financial inclusion is an important area of work for WSBI and its members, and it has become one of the most essential international policy issues worldwide to help address social-economic development and economic growth, especially in the aftermath of financial crisis.


Designed to display name cards or reservation notices clearly, our angled place card holders are ideal for weddings venues, restaurants, bars, etc.
Manufactured in the UK, these angled place card holders have been made from premium polystyrene plastic to ensure that they are of the highest possible quality.
Designed to keep the cards placed inside them clean and easy to view, these plastic card holders are completely see-through and will allow place cards with decorative barriers and embellishments to be seen unhindered.


David Anderson describes five criteria necessary for an individual to develop himself as a blogger; create a brand, be unique, develop your expertise, define your audience, and keep them interested. In order to create a brand, the blogger must first establish credibility. This can be done by a written introduction, an audio podcast, and/ or youtube videos. The purpose is to show the readers that the blogger is just like any other individual with interesting views and a unique perspective. More importantly, it gives a face to the written word. Being unique is extremely important for a blogger to distinguish himself from million other bloggers. This can be accomplished by the blogger focusing and developing his strengths. Developing your expertise is also very important to stand out from the crowd. The blogger must make sure he is well-read on the topic he is interested in. Defining your audience helps the author to find a niche market for his unique blog. This is important because bloggers must first make sure to have a loyal fan base before expanding. Lastly, keep them interested entails that the blogger post new and interesting information on a regular basis.


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PLAYERS | Darryl Brohman
22 May 2018 mightypanthers Leave a comment
95 matches [1979-1983; 1986-1987]
54 points [12 tries, 7 goals]
Stats: themightypanthers.com/players_brohman-daryl.htm
Brisbane Norths forward who debuted in 1976 in the Brisbane competition before being signed to come down to Sydney to play for Penrith in 1979.
Alternating between the front and second row, he was a skilful ball player who added a much needed touch of class to Penrith's attack.
Brohman became the Panthers second representative in the then fledgling State of Origin series, debuting for Queensland in 1983. A broken jaw suffered in his Queensland debut reportedly denied him an opportunity to make his Test debut later in the year. Unfortunately, it would be the closest he would get to selection for higher honours.
He departed for Canterbury in 1984, winning back to back premierships at the Bulldogs before making a return to Penrith in 1986. He made a return to the Queensland team for a second appearance in 1986. 1987 would be his final season, making only seven first grade appearances, but bowed out on a high being a member of the club's maiden reserve grade premiership.
Post retirement, he would enter coaching, being the reserve grade coach at Brisbane and Canterbury before returning to Penrith to be an assistant to Phil Gould, before entering a long career in the media, both in television and radio.
Previous PostPLAYERS | Preston CampbellNext PostPLAYERS | Terry Geary


You may bore of socks or ties but if you buy a residential or commercial Tenerife property before 31 December there is a great festive present of a 50% discount on future capital gains tax. That one is already wrapped and waiting for you but with an eye to encouraging investments to Spain the government is bringing in a law offering residencia permits on apartment purchases of over 160,000 euros. We are waiting to see if that is extended to commercial properties, it certainly fits in with Tenerife policy to welcome new business.
The festive season is brighter and longer than in most countries due to Reyes - Kings Day on 6 January so there is a packed few weeks when old friends and customers return for their much needed Tenerife top up and potential buyers take a holiday to see at first hand the business bargains of Tenerife bars, cafes, and restaurants. This fits nicely in the middle of the established season of Scandinavian and Russian visitors and the loyal community of "swallows" who head out from the UK and mainland Europe for the winter sun that Tenerife is famed for.
Tenerife Tourism realize that many people plan future holidays when gathered together over the festive season so they have a major advertising campaign on television around Europe and stands at the big tourism fairs that are held in the winter. That's why visitors from all over Europe and beyond are on the increase.
It would be easy to be complacent and think that beautiful weather, stunning scenery and rich culture is enough to make Tenerife stand out among holiday destinations but on this island there is always a willingness to try more. Los Cristianos has just welcomed Sea Cloud, a small cruise ship to test the response of passengers, they were impressed and in 2013 the bigger liners are popping in. The World arrives on 25 February with 550 passengers and Albatross calls on 18 April, 5 May and 9 December with 900 tourists all keen to sample food and drink from local Tenerife cafes and to buy souvenirs of a happy visit.
Those living in Tenerife like to enjoy top shows like Cirque de Soleil, in Santa Cruz in January, while the musical reflections of History at the Magma Arts & Congress, and Carmen Mota's flamenco extravaganza Evolution at the Piramides de Arona will thrill the south all year. The best nights out start and finish with a meal and drinks in a nearby Tenerife restaurant or bar- something appreciated by the many satisfied business investors who use the services of FRINA Tenerife.
Combining international business with pleasure has made Tenerife a popular venue for large companies to hold conventions and annual meetings, who can blame them with top hotels and golf courses on hand. The Tenerife government is not slow to spot good business opportunities and is committed to making Tenerife a magnet to convention organizers. Promotions like Why Tenerife help to focus business minds on our shores, even the film industry is flocking here, Vin Diesel and friends enjoyed a lively few months here filming The Fast & The Furious 6.
We can't promise you film stars but FRINA Tenerife can promise the best service and inside Tenerife business knowledge.
From all at FRINA Tenerife we wish you all a wonderful relaxing Christmas, New Year, and Reyes and look forward to helping make your 2013 a prosperous one.


Besides visiting the extensive exhibition floor where vacancies of more than 100 companies from the maritime, offshore and energy sector can be discovered, there's lots of opportunities to gain knowledge during the Navingo Career Event. This is important, because innovations in the sector follow one another rapidly. But what do these developments mean for career perspectives? At Community Square, these themes are discussed. Experts talk to each other and the audience during each talkshow to about several themes that will radically change the industry in the upcoming years.
Community Square is kicked off with the first talkshow 'The reality of sustainability'. Sustainable entrepreneuring is no longer something only idealists do. Regulations and the market force companies to make greener choices. To which extent do old thinking patterns have to be unlearned, and is a new generation necessary to make any real changes? Does the current education system sufficiently connect to this? And how important is the sustainable image of a company for recruiting talent?
Another theme that almost each company encounters, is digitalization. Together with Microsoft, the talkshow ' Digital Transformation' is presented. What does the Internet of Things mean for the maritime sector? And do these developments influence the kind of jobs that will be offered? Eric van Uum, Technical Specialist within Microsoft's World Wide Black Belt Team for IoT (Internet of Things) takes us with him and gives us a sneak peek into the future.
Besides attending the talkshows, visitors can also gain knowledge at the workshops and case studies organized by top companies. Besides that, presentations can be seen at 'The Stage'. Several professionals from various disciplines tread the stage to talk about their day to day activities and what it means to work in this adventurous sector.


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Q: Add columns to SQL query output I have searched this site and others, and I am unable to find a clear answer, so here I am. In the below query, I will get an output with a single column for the county. What I would like to do can only be described in Excel parlance as transpose the counties so each county for a brand family is in its own column. I have played around with using pivot, but unfortunately do not fully grasp what would be required. This is not my first query, but I am relatively new to SQL scripting, so please ask any clarification questions and I will do my best to answer.
Some of the brand families have 10 counties and some have 20, so some of the columns would be blank. This is for an in-house DB, not the SO DB, running on SQL Server 2008R2, FWIW.
The script is:
select distinct b.reckey as BrandFamilyKey, b.recname as BrandFamilyName,
       g.recname as County
from territories as t
left join dbo.TerritoryBrandFamilies as tbf on tbf.TerritoryNid = t.TerritoryNid
left join Customers as c on c.TerritoryNid = t.TerritoryNid
left join GeographicAreas as g on g.GeoAreaNid = c.GeoAreaNid
left join brandfamilies as b on b.brandfamilynid = tbf.brandfamilynid

where t.activeflag = 1 AND C.GeoAreaNid IS NOT NULL and b.activeflag = 1

order by b.RecName,g.recname

the output would look like
brand family 1     county 1
brand family 1     county 2
brand family 1     county 3

What I would like to see is:
brand family 1     county 1     county 2     county 3

redpajama_set_name: RedPajamaStackExchange


"MISCIBILITY AND VISCOELASTIC PROPERTIES OF BLENDS OF A LIQUID-CRYSTALL" by YG LIN, HW LEE et al.
LIN, YG; LEE, HW; Winter, HH; DASHEVSKY, S; and KIM, KS, "MISCIBILITY AND VISCOELASTIC PROPERTIES OF BLENDS OF A LIQUID-CRYSTALLINE POLYMER AND POLY(ETHYLENE-TEREPHTHALATE)" (1993). POLYMER. 819.


We had a wonderful service on Sunday with powerful Praise and Worship and Prayer sessions with great joy in the Lord. One could feel His presence over the Congregation. The Lord brought 8 visitors among them 3 who accepted the Lord and joined the Flock and 4 were on their way to Nairobi. We had good time in ministry over the Sick and Needy. The Sermon of the meaning of the Cross brought many to their knees in the purpose of His sufferance, Death and resurrection. The Word touched many and healed us!!!
Prayers and Intercession continue this week as we look forward to usher in Pastors and Leaders from Kenya and Uganda for Conference. Several more souls turned to Jesus last week with evangelists and intercessors going round in homes seeking for the lost and needy.
A 3 day Assembly Youth Conference at Chwele GBF Church 35 miles saw about 80 Youths attend. We were invited to teach on Friday before we headed to Igara on Saturday for another Youth Conference.
We traveled to Igara GBF Church 32 miles in Busia County on last Saturday April 22nd, for a one day District Youth Conference that started with a watch-over night. We had a wonderful time ministering to the Youth and the Lord moved.
We will be busy with Pastor/ Leaders Conference as from this Wednesday April 26th to Saturday 29th. Please, pray for us!!!!


Amanda Murphy Design: My pattern line is shipping!
So they should start arriving at shops within a few days. Interested shops can email me; as shops order my patterns I will be adding them to my webpage. If you choose to buy the patterns from a distributor, please email me to let me know you carry them and I'll add you to the list.
In response to inquiries, I do not carry my fabrics - I leave that to Robert Kaufman. You can order "Veranda", the fabric line that I used for all the patterns, now for August delivery. Please make sure to order ahead of time to ensure you get the fabrics.


text:
Q: Java Connection pacakge with mysql not working for jsp pages in eclipse by usebean i made a package in eclipse to connect to mysql of wamp server to execute my sql query of a jsp page.This same code works perfectly fine on netbeans but not on eclipse.I think this is resulting as i was using glassfish server on netbeans and tomcat on eclipse.My package is located under src folder of java packages in eclipse.
This is my javabean object.
<jsp:useBean id="c1" scope="page" class="sql.connect" />

This is the error that i get unable to compile jsp class
SEVERE: Servlet.service() for servlet [jsp] in context with path [/IP Programming Discussion Platform] threw exception [Unable to compile class for JSP] with root cause
java.lang.IllegalArgumentException: Page directive: invalid value for import
    at org.apache.jasper.compiler.Node$PageDirective.validateImport(Node.java:628)
    at org.apache.jasper.compiler.Node$PageDirective.addImport(Node.java:609)
    at org.apache.jasper.compiler.Parser.parsePageDirective(Parser.java:352)
    at org.apache.jasper.compiler.Parser.parseDirective(Parser.java:473)
    at org.apache.jasper.compiler.Parser.parseFileDirectives(Parser.java:1773)
    at org.apache.jasper.compiler.Parser.parse(Parser.java:135)
    at org.apache.jasper.compiler.ParserController.doParse(ParserController.java:242)
    at org.apache.jasper.compiler.ParserController.parseDirectives(ParserController.java:119)
    at org.apache.jasper.compiler.Compiler.generateJava(Compiler.java:194)
    at org.apache.jasper.compiler.Compiler.compile(Compiler.java:374)
    at org.apache.jasper.compiler.Compiler.compile(Compiler.java:354)
    at org.apache.jasper.compiler.Compiler.compile(Compiler.java:341)
    at org.apache.jasper.JspCompilationContext.compile(JspCompilationContext.java:660)
    at org.apache.jasper.servlet.JspServletWrapper.service(JspServletWrapper.java:364)
    at org.apache.jasper.servlet.JspServlet.serviceJspFile(JspServlet.java:395)
    at org.apache.jasper.servlet.JspServlet.service(JspServlet.java:339)
    at javax.servlet.http.HttpServlet.service(HttpServlet.java:731)
    at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:303)
    at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
    at org.apache.tomcat.websocket.server.WsFilter.doFilter(WsFilter.java:52)
    at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241)
    at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
    at org.apache.catalina.core.StandardWrapperValve.invoke(StandardWrapperValve.java:219)
    at org.apache.catalina.core.StandardContextValve.invoke(StandardContextValve.java:110)
    at org.apache.catalina.core.StandardHostValve.invoke(StandardHostValve.java:169)
    at org.apache.catalina.valves.ErrorReportValve.invoke(ErrorReportValve.java:103)
    at org.apache.catalina.valves.AccessLogValve.invoke(AccessLogValve.java:962)
    at org.apache.catalina.core.StandardEngineValve.invoke(StandardEngineValve.java:116)
    at org.apache.catalina.connector.CoyoteAdapter.service(CoyoteAdapter.java:445)
    at org.apache.coyote.http11.AbstractHttp11Processor.process(AbstractHttp11Processor.java:1115)
    at org.apache.coyote.AbstractProtocol$AbstractConnectionHandler.process(AbstractProtocol.java:637)
    at org.apache.tomcat.util.net.JIoEndpoint$SocketProcessor.run(JIoEndpoint.java:316)
    at java.util.concurrent.ThreadPoolExecutor.runWorker(ThreadPoolExecutor.java:1149)
    at java.util.concurrent.ThreadPoolExecutor$Worker.run(ThreadPoolExecutor.java:624)
    at org.apache.tomcat.util.threads.TaskThread$WrappingRunnable.run(TaskThread.java:61) at java.lang.Thread.run(Thread.java:748)


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Hasegawa, K. (1997)Sunken wood-associated gastropods collected from Suruga Bay, Pacific side of the central Honshu, Japan, with descriptions of 12 new species.National Science Museum Monographs, Tokyo 12: 59-123.
Sasaki, T. (2000)Family Cocculinidae.In: Okutani, T. (ed.), Marine Mollusks in Japan. Tokai University Press, Tokyo, 35 (in Japanese).


Whether you are looking to tone and strengthen, improve core strength, lose weight, or simply get healthy and fit, the BOSU® Color Customized 65 cm Balance Trainer. This half ball comes in a variety of colors for a fun and personalized workout experience. Use the trainer, dome or platform side down; the options and exercise progressions are endless, and help to enhance mobility, strength, balance, and overall fitness levels.
Product diameter: 26"/ 65 cm.
90 day limited for home usage only. Warranty is void if used in a commercial setting.


Why would anybody want to be a teacher?
Why would anybody want to be a teacher? Let alone a middle/high school teacher? Aren't those kids awful? I couldn't do it! Teenagers are so disrespectful nowadays! They're so entitled! How can you stand it? Especially when you know you'll never make any money? NO WAY!
If you've been a teacher for more than five minutes, I'm sure you've heard some version of this rant, whether from a friend, family member, or even a stranger who wanted to give you their two cents about your chosen profession. I have asked myself some of these very same questions in moments of crisis or despair.
Yes, I am crazy. Yes, I think I can change the world. Yes, I enjoy being around kids (most of the time). Yes, I knew I wouldn't ever get rich doing this job. Yes, sometimes I cry in the parking lot. Yes, teenagers can be disrespectful, and entitled, and mean (so can most people by the way).
Yes, I'm still a teacher.
I went to Texas A&M, and we have a saying- "From the outside looking in, you can't understand it. From the inside looking out, you can't explain it." That is a spot-on way to describe teachers vs non-teachers.
If you've never seen a kid's eyes light up because they finally understood something they had been struggling to learn, you can't fathom what that's like. You've never had a kid cry and hug you and thank you because they finally passed their state assessment for the first time, ever, so you can't imagine what kind of payment that is to a teacher's heart. If you've never realized that the disruptive kid is just acting out because he doesn't recognize what love and caring is, then you would just see the disrespect and entitlement.
For me, the joy of teaching is truly the kids. I have NEVER wanted to leave a job, or cried in a parking lot because of the kids. It's always been the administration or parents or colleagues or too many meetings or unrealistic expectations that have caused that. I think true teachers realize that, no matter what the jerk principal or jerk parent or jerk colleague does, the kids still need us. Even if it's the kid being the jerk, it's usually because they need us the most.
Don't get me wrong, I can argue with you all day about how stupid it is that people who play a game or act make 57 times more than we do. I'd like to see any one of them come and sub in a classroom, then realize how much they will be getting paid, and watch how fast they walk out. This job isn't for the faint of heart. In fact, your heart will take the biggest beating! You have to be called, and I think that's why teachers put up with so much other nonsense and keep fighting the good fight. It's in our DNA.
It's great for my ADD. I'm all about fresh starts. If you want a fresh start every year, heck, every day, this is the gig for you. When a lesson falls flat, I get to try again. When a particular group of students is tough, I get a new group the next year. Had a bad day? You get to do something different tomorrow.
Teenagers are HILARIOUS. I cannot tell you how many times the wit and humor that comes out of these kids has knocked me flat.
Those are my top three. I'm sure others have different reasons, so share them in the comments!


This week's tip is an assisted streamline, which is a body position exercise that can help swimmers of all ages. One swimmer will be in the water attached to a bungee cord, while a coach or partner walks with the other end of the cord the length of the pool before pulling them down to the other side. While being pulled, the person in the water should be in a streamlined position as they rocket down the pool.
Being pulled by the bungee creates a heightened sense of body awareness and where resistance may be slowing us down. The speed from the bungee will make swimmers more aware of how the angle of the head, arms, fingertips, legs, and the alignment of their entire body may be slowing them down, and will also force them to use their core to stay traveling in a straight line.
Most importantly, this drill is fun. The tighter your streamline, the faster you will ultimately go, making this a great drill for younger swimmers who may need some more incentive to work on their streamlines and body position off the wall. Do this drill before some faster swims as a reminder of what it should feel like to come off the wall with as little resistance as possible.


text:
Green Energy Project - Paul Bardacke - Villagra
Paul Bardacke – Villagra
Paul Bardacke is a former state attorney general and a partner in the Bardacke Allison law firm in Santa Fe.
Bardacke served as attorney general from 1983 through 1986. His other work experience includes Special U.S. Attorney for District of New Mexico, 1984-1985; Instructor, Evidence and Trial Practice, University of New Mexico Law School, 1973-1982; Faculty, National Institute of Trial Advocacy, 1978; and Special Counsel to State of New Mexico, Windfall Profits Tax Litigation, 1981-1985.
Bardacke was formerly a partner in Eaves, Bardacke, Baugh, Kierst & Larson. He was admitted to the bar in California in 1969 and in New Mexico in 1970. He has been admitted to practice before U.S. district and appeals courts, as well as the Supreme Court. Bardacke attended the University of California at Santa Barbara and law school at the University of California at Berkeley.
ECM-1 Lighting Mon 7/13/20 Thu 7/30/20
ECM-2 HVAC & Controls, 2 Boiler Replacement Add Pumps, Mon 10/14/19 Tue 11/19/19
ECM-2 HVAC & Controls – SC Mon 9/16/19 Tue 6/16/20
ECM-2 HVAC & Controls, Clean HTX Mon 3/16/20 Fri 3/20/20
ECM-3 Building Envelope, Window Film Tue 9/3/19 Tue 9/10/19
ECM-3 Building Envelope, Mon 4/27/20 Wed 4/29/20
ECM-4, Water Conservation Wed 3/25/20 Mon 3/30/20
ECM-5, Transformers – 5 Sat 12/21/19 Sun 12/22/19
Anticipated Annual Energy Savings: $19,082
Bardacke-Villagra
Address: 408 Galisteo St.
New Addition: 2005
1934 Wing Renovated: 2005