text:
Volume 81, Issue 961
Cinical and pathological characteristics of Chinese patients with antineutrophil cytoplasmic autoantibody associated systemic vasculitides: a study of 426 patients from a single centre
M Chen,
F Yu,
Y Zhang,
M H Zhao
Renal Division and Institute of Nephrology, Peking University First Hospital, Beijing, PR China
Correspondence to:
Dr M H Zhao
Renal Division and Institute of Nephrology, Peking University First Hospital, Beijing 100034, PR China; mhzhaobjmu.edu.cn
Background: Antineutrophil cytoplasmic autoantibodies (ANCA) are serological markers of ANCA associated systemic vasculitides (AASV), which is one of the most common multisystem autoimmune diseases. Features of Chinese patients with AASV have not been fully investigated.
Objective: To analyse the clinical and pathological characteristics of Chinese patients with AASV.
Methods: 426 Chinese patients with AASV diagnosed in the past eight years were retrospectively studied and their clinical and pathological data were analysed.
Results: Of the 426 patients, 87 (20.4%) were Wegener's granulomatosis, 337 (79.1%) were microscopic polyangiitis and two (0.5%) were Churg-Strauss syndrome. Only 201 of 426 (47.2%) patients were diagnosed within three months. Clinically, the patients had multisystem involvement. Altogether 371 of 426 (87.1%) had kidney involvement and 260 of 426 (61.0%) had lung involvement. The prevalences of renal involvement and fatigue were significantly higher in patients with MPO-ANCA than that in patients with PR3-ANCA; the prevalences of ophthalmic, nasal involvement, rash, and arthragia were significantly higher in patients with PR3-ANCA than those in patients with MPO-ANCA. The one and five year death rates were 13.1% and 22.4%, respectively. The percentage of patients progressing to end stage renal disease at one and five years was 15.9% and 27.1%, respectively.
Conclusions: AASV is not a rare autoimmune disease in Chinese people. Kidney and lung were the most vulnerable organs. For patients with multiorgan damage, an ANCA test should be performed to make an early diagnosis and to start treatment in time.
ANCA, antinuetrophil cytoplasmic autoantibodies
AASV, ANCA associated systemic vasculitides
WG, Wegener's granulomatosis
MPA, microscopic polyangiitis
CSS, Churg-Strauss syndrome
ACR, American College of Rheumatology
ANA, antinuclear antibodies
ESR, erythrocyte sedimentation rate
MMF, mycophenolate mofetil
MPO, myeloperoxidase
vasculitide
http://dx.doi.org/10.1136/pgmj.2005.034215
Vasculitis is an inflammatory process of blood vessels, histopathologically characterised by vessel wall destruction and occlusion of the vascular lumen. An attempt to classify the diverse forms of vasculitis resulted in the Chapel Hill international consensus definition, which used the vessel size as the determinant of classification.1 American College of Rheumatology (ACR) has proposed classification criteria for some of the diseases.2 Wegener's granulomatosis (WG), microscopic polyangiitis (MPA), Churg-Strauss syndrome (CSS), and idiopathic rapidly progressive glomerulonephritis (iRPGN) are described as small vessel vasculitides and are acknowledged to be commonly associated with antineutrophil cytoplasmic autoantibodies (ANCA). They are termed as ANCA associated systemic vasculitides (AASV). Two fluorescence patterns of ANCAs are distinguished by indirect immunofluorescence (IIF), the cytoplasmic staining pattern (cANCA), and the perinuclear staining pattern (pANCA). Most patients with a cANCA pattern obtained by IIF have ANCAs directed against proteinase-3 (PR3), as determined by antigen specific ELISA. Patients with a pANCA mostly have ANCAs directed against one of a variety of antigens, such as myeloperoxidase (MPO). The combination of a cANCA with PR3-ANCA and pANCA with MPO-ANCA are specific for WG, MPA, or iRPGN.3
AASV must be recognised in time if successful treatment is to be implemented. Early diagnosis and appropriate immunosuppressive treatment are crucial for reducing the ability of acute vasculitis to cause death from major organ failure, for example, respiratory failure from pulmonary haemorrhage, and to reduce long term morbidity, for example, end stage renal failure.
AASV is one of the most common multisystem autoimmune diseases in the white population. A population based study from Norfolk, England, reported incidences of 8.5 cases per million for WG, 3.6 cases per million for MPA, and 2.4 cases per million for the CSS.4 In two large US cohorts studies of patients with WG,5,6 white people comprised more than 90% of all cases. Regional, geographical, ethnic, and seasonal differences in disease patterns and increasing incidence have been suggested, but lack confirmation.7 Studies from Norway suggested a doubling incidence of WG from 1992–1994 to 1995–1998. These figures probably reflect a real increase in incidence as well as improved awareness and diagnosis. AASV can occur at any age, especially elderly people.
The incidence of AASV in the Chinese population is unknown. In the early 1990s, after IIF-ANCA and ELISA using crude neutrophil acid extracts as solid phase ligands were established, a retrospective study of 50 hospitalised Chinese patients with crescentic glomerulonephritis or end stage renal disease showed that five of the 50 patients were ANCA positive.8 With the commercial IIF-ANCA kits being available and purified MPO and PR3 being used in routine ANCA screening assays, the prevalence of AASV increased substantially. In the past eight years, 426 patients with AASV were diagnosed in Peking University First Hospital. The prevalence of ANCA and the antigen specificities, as well as demographic features of some of the Chinese patients with AASV was investigated.9 It was suggested that AASV might not be rare in the Chinese population. In this study, the clinical and pathological manifestations of the Chinese patients with AASV were investigated.
A total of 426 patients with AASV, diagnosed from 1997 to 2004 in the Institute of Nephrology, Peking University First Hospital, were enrolled into this retrospective study. All the patients met the criteria of the Chapel Hill consensus conference definition (for WG, MPA, or CSS) and ACR classification criteria (for WG or CSS). Systemic lupus erythematosus, Henoch-Schölein purpura, rheumatoid arthritis were excluded. Acute renal failure was defined by the presence of progressively raised serum creatinine or 15% declined clearance rate of serum creatinine on the baseline within days or weeks. Clinical data were collected and analysed according to the organ involved.
IIF assay to detect ANCA
Standard IIF assay was performed accoding to the manufacturer (EUROIMMUN, Lübeck, Germany). Ethanol fixed human polymorphonuclear leucocytes (PMN) were used to detect ANCA and monkey liver sections were used to exclude antinuclear antibodies (ANA). cANCA and pANCA were distinguished according to staining patterns by two experienced technicians.
Antigen specific ELISAs
Two highly purified known ANCA antigens, PR3 and MPO, were used as solid phase ligands in ELISA, as previously reported.10
Pathological examination
Renal pathological data of 122 cases were evaluated using direct immunofluorescence, light and electron microscopy. Specimens of kidney were required to have a minimum of 10 glomeruli for classification of glomerulonephritis with light microscopy by the same renal pathologist.
Induction treatment included corticosteroids and cyclophosphamide (CTX). Oral prednisone was prescribed at an initial dose of 1 mg/kg/day for four to six weeks, with reducing doses over time to 12.5 to 15 mg by three months. CTX started on day 10–14 days after corticosteroids, daily oral 2 mg/kg/day or intravenous 0.7 g/m2 every month. Patients with acute renal failure or pulmonary haemorrhage received three pulses of intravenous methylprednisolone (7–15 mg/kg/day) before standard induction treatment. Some patients with severe pulmonary haemorrhage received additionally plasma exchanges. Azathioprine or mycophenolate mofetil (MMF) was given in maintenance treatment.
Remission was defined as the absence of clinical signs or symptoms or laboratory evidence of vasculitis activity. Relapse was defined as the return of clinical signs or symptoms or laboratory evidence of disease activity sufficient to warrant a sustained increase in immunosuppressive treatment.
Prevalence and demographic features
Of the 426 patients with AASV diagnosed from 1997 to 2004, 199 (46.7%) were male and 227 (53.3%) were female. Most of the patients were from northern China. There was no significant occupation of the patients. The average age was 56.1 (range 5–83) years old. Altogether 176 (41.3%) cases were older than 65 years old and 38 (8.92%) cases were younger than 20 years old. The number of diagnosed case increased chronologically (fig 1). Eighty seven patients (20.4%) were WG, 337 (79.1%) were MPA, and two (0.5%) were CSS. Seventy (16.4%) of these patients were positive for cANCA. Sixty nine of them could recognise PR3 only and the rest one could recognise both PR3 and MPO in antigen specific ELISA. Altogether 354 (83.1%) patients were positive for pANCA with antigen specificity for MPO only in 346 (346 of 354, 97.7%) patients, and positive for both MPO and PR3 in eight cases (8 of 354, 2.3%). Two of 426 patients were positive for both pANCA and cANCA. One of them could recognise MPO only and the other could recognise both MPO and PR3 (table 1).
ANCA results of serum samples in IIF and ELISA
Patients with AASV diagnosed chronologically.
Interval between onset of the disease and diagnosis
The mean and median time between onset of the disease and testing for ANCA were 237.6 (ranging from 3 to 1460) and 60 days, respectively. Only 99 cases (23.2%) were diagnosed within 30 days, 47.2% (201) cases within 90 days, 252 cases (59.2%) within 180 days, 47 (11.0%) cases more than one year, and one case was even diagnosed four years after the onset of the disease. There was no significant difference of the interval between onset of the disease and diagnosis between patients with PR3-ANCA and MPO-ANCA.
Of the 426 cases, 260 (61.0%) had fatigue, 242 (56.8%) had fever, 171 cases (40.1%) had significant weight loss, 84 cases (30.8%) had arthralgia, 110 (25.8%) cases had muscle pain, and 78 (18.3%) cases had a rash.
Renal manifestations
A total of 371 cases (371 of 426, 87.1%) had renal involvement, of which 334 (90.0%) had haematuria, 314 (84.6%) had proteinuria, 307 (82.7%) had raised serum creatinine with 229 (61.7%) diagnosed to have acute renal failure, and only 31 cases (8.36%) had nephrotic syndrome. Altogether 122 cases (32.9%) had a renal biopsy, of which 38 (31.1%) had focal segmental fibrinoid necrosis in glomeruli, 12 (9.84%) had fibrinoid necrosis in arterioles, 83 (68.0%) reached the criteria of crescentic glomerulonephritis (over 50% glomeruli had large crescents formation), and 11 (9.02%) had granulomatous lesion in renal interstitium.
Pulmonary manifestations
Two hundred and sixty cases (260 of 426, 61.0%) had lung symptoms such as cough, often with sputum production, of which 104 (40.0%) had haemoptysis. One hundred and fifty cases had alveolar infiltrates or interstitial changes on chest films or computed tomography, of which 130 cases (86.7%) had shadows in one or both lungs and 79 (52.7%) had pulmonary interstitial fibrosis, multiple nodules, or cavitations.
Manifestations of other organs
Of the 426 patients, 83 cases (19.5%) had ophthalmic disease manifested as conjunctivitis, keratohelcosis, episcleritis and uveiitis, optical nerve vasculitis, and declining vision. Ninety nine cases (23.2%) had ear involvements, manifested as tinnitus, perforation of the tympanic membrane, and declining or loss of hearing. Thirty five cases (8.22%) had nasal involvement, manifested as sinusitis, stuffiness, epistaxis, and brown or bloody crusts, rhinitis, septal erosions, or even septal perforation. One hundred and eighty three cases (43.0%) had gastrointestinal involvement manifested as nausea, vomiting, anorexia, abdominal pain, loose bowels, or bloody faeces. Five patients had a gastrointestinal ulcer. Sixty seven cases (15.7%) had neurological disorders such as peripheral mononeritis multiplex, dizziness, headache, and coma. Three patients has cerebral haemorrhage. One patient had Guillain-Barre syndrome (fig 2).
Prevalences of organ involvement.
Further analysis showed that the prevalences of renal involvement and fatigue were significantly higher in patients with MPO-ANCA than that in patients with PR3-ANCA (90.2% v 79.7%, χ2 = 6.21, p<0.05; 63.7% v 46.4%, χ2 = 7.24, p<0.01, respectively); the prevalences of ophthalmic, nasal involvement, rash, and arthragia were significantly higher in patients with PR3-ANCA than those in patients with MPO-ANCA (31.9% v 16.7%, χ2 = 8.53, p<0.01; 21.7% v 5.76%, χ2 = 19.1, p<0.01; 27.5% v 16.4%, χ2 = 4.76%, p<0.05; 43.5% v 28.0%, χ2 = 6.54, p<0.05, respectively) (table 2).
Clinical manifestations of 426 patients with AASV
Laboratory findings
A total of 300 of 337 cases (89.0%) had anaemia, of which only 83 cases (27.7%) had mild anaemia with haemoglobin (Hb) over 90 g/l, 172 cases (57.3%) had moderate anaemia with Hb between 60 and 90 g/l, and 45 (15.0%) had severe anaemia with Hb less than 60 g/l. Altogether 125 of 287 (43.6%) cases had leucocytosis and 56 of 195 (28.7%) had thrombocytosis. A total of 265 of 285 cases (93.0%) had raised erythrocyte sedimentation rate (ESR), of which 92 (34.7%) were over 100 mm 1st h and 178 (67.2%) were over 60 mm 1st h. Altogether 132 of 185 cases (71.4%) had raised C reactive protein. No significant difference was found in these laboratory findings between PR3-ANCA and MPO-ANCA positive patients.
A total of 44 of 130 (33.8%) and 86 of 130 (66.2%) cases received prednisone together with daily oral or monthly intravenous CTX, respectively. After the induction phase treatment, 105 of 130 (88.5%) cases had complete or partial remission. One hundred and seven cases were followed up. The average duration of follow up was 29.7 (1–108) months. A total of 24 of 107 (22.4%) patients died and 29 of 107 (27.1%) patients progressed to end stage renal disease and received renal replacement treatment. The one and five year death rates were 13.1% and 22.4%, respectively. The percentage of patients progressing to end stage renal disease at one and five years was 15.9% and 27.1% respectively.
AASV is one of the most common multisystem autoimmune diseases in the white population. It is an important cause of mortality (if untreated) and morbidity (despite current aggressive treatment). The annual incidence and point prevalence of renal vasculitis in Europe is 10–20/million/year and 150–200/million, respectively.7,11 In China, after improved awareness and diagnostic techniques, more patients with AASV were diagnosed in recent years, but there is lack of systemic investigation on incidence. Over 400 patients with AASV were diagnosed in our centre in the past eight years and the number of patients increased chronologically. It was suggested that AASV was not rare in China.
In this study, it was found that the average age of Chinese patients with AASV was 56.1 (ranging from 5 to 83) years old. Over 40% of the cases were more than 65 years old, and nearly 1 of 10 of the cases were younger than 20 years old, showing that AASV could affect people of all age—elderly people were more susceptible, but children and teenagers were not rare. This is consistent with our previous studies and similar to the white population.11–14
MPO and PR3 are the two important target antigens of ANCA for Chinese patients with AASV, which is consistent with the epidemiology reports in white populations.7,15 However, in our study, patients with MPA were about four times as many as patients with WG. Substantial evidences suggested that throughout Europe, there is a different proportion of WG and MPA. In northern Europe and Germany there are many more patients with WG than MPA, whereas in southern Europe, a study from Spain suggested that patients with MPA were about two to three times as many patients with WG.11,16–18 This may be attributed to the geographical, environmental, or genetic differences as there had been evidence that geographical and genetic factors both played a part in the pathogenesis of AASV. The preponderance of MPA might be one of the epidemiological characteristics of Chinese patients with AASV.
Kidney and lung are the two most vulnerable organs to be involved in patients with AASV. In this study, nearly 90% of cases had renal involvement and more than 60% of them had acute renal failure, which might be the major cause for long term end stage organ damage. However, the high prevalence of renal involvement might be to some extend a result of selective bias, because most patients with renal diseases were referred to us. Another possible reason might be the unawareness of the systemic disease by physicians and thus resulted in late diagnosis and increased prevalence of renal involvement. The prevalence of renal involvement and acute renal failure reported by the respiratory department in our hospital was 76.9% (10 of 13) and 38.5% (5 of 13), respectively.19 More than 60% had pulmonary involvement with 40% having pulmonary haemorrhage, which was the major cause of acute respiratory failure or death. Although 43% and 15.7% of the cases had gastrointestinal and nervous involvement respectively, they were often neglected by clinicians and these might be under-evaluated in this retrospective study. Besides visceral vasculitis, about 8% to 23% also suffered from auditory, ophthalmic, and nasal involvements. All the above mentioned findings showed that AASV is characterised by multisystem injury.
Although cANCA/PR3-ANCA was mainly found in patients with WG and pANCA/MPO-ANCA was mainly found in patients with MPA and iRPGN, it was not exclusive. Our study also found that there were some difference in the clinical manifestations between patients with PR3-ANCA and MPO-ANCA. The prevalences of fatigue and renal involvement were significantly higher in patients with MPO-ANCA than those in patients with PR3-ANCA. The prevalences of ophthalmic, nasal invlovement, rash, and arthragia were significantly higher in patients with PR3-ANCA than those in patients with MPO-ANCA. Some authors argued that one of the possible reasons for higher proportion of renal disease in patients with MPO-ANCA positive might be attributable to the delay of diagnosis. More patients with PR3-ANCA positive had upper respiratory and ophthalmic involvements, which probably reduce the patients' and doctors' delay. Earlier diagnosis and start of treatment might reduce the frequecy of renal involvements.20–23 In this study, however, there is no significant difference of the intervals between onset of disease and diagnosis between PR3-ANCA and MPO-ANCA groups. Whether there are different mechanisms in the pathogenesis of renal disease in these ANCA subsets remains unclear.
Aberrant laboratory findings suggestive of active vasculitis included severe anaemia unparalleled with the degree of renal failure or pulmonary haemorrhage, or both, leucocytosis, thrombocytosis, increased non-specific inflammatory markers such as ESR and C reactive protein.24 The laboratory findings of our patients showed that most of them were in active phase at the time of diagnosis.
This study also preliminarily analysed the outcome of the patients. However, there were many patients lost during follow up, so the actual mortality and rate of end stage renal disease might be much higher.
The prognosis of untreated AASV is poor, with up to 90% of patients dying within two years.5 Early diagnosis is crucial, otherwise life threatening disease such as acute renal failure or respiratory failure may develop quickly. In this study, unfortunately, more than 40% of the patients were diagnosed six months after onset of the disease, and more than 10% of the cases were more than one year, which would undoubtedly worsen the prognosis. This showed that the awareness of this disease still needs to be improved in clinicians. Vassilopoulos25 reported that in patients with severe multiorgan dysfunction or pulmonary disorders, there was a high prevalence of ANCA. Therefore, for the suspected patients, prompt ANCA detection is crucial for the early diagnosis of AASV.
AASV is not rare in the Chinese population. Renal and pulmonary involvement was common and life threatening. For patients with multisystem involvement, ANCA testing using both IIF and antigen specific ELISA is recommended and it provides a helpful tool facilitating earlier diagnosis.
We are grateful to Dr Yanping Peng for assistance in collecting the data of the patients.
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Franssen CF, Stegeman CA, Kallenberg CG, et al. Antiproteinase 3 and antimyeloperoxidase-associated vasculitis. Kidney Int2000;57:2195–206.
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Ethics approval and patient consent: this research was approved by the ethnics committee of Peking University First Hospital (Peking University First Hospital, Beijing 100034, PR China) and with informed consent of patients.
Funding: none.
Conflicts of interest: none.
Copyright 2005 The Fellowship of Postgraduate Medicine


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I have been trying to save money but sometimes, I just can't help myself. I just had to buy that beautiful serving tray or that gorgeous little white cup and saucer. I love Scandinavian inspired interiors and that is the look I want to recreate in my home. You will see a lot of white and wood coming back in my interior. I love having a few basic items in my home so I can add different pops of colour depending on the season.
Without further ado... Here are my favourite places to buy homeware!
Casa is a Belgian chain store with stores in a bunch of European countries. They have an amazing range of homeware and kitchen essentials. Plus they change their collections regularly. I often (yes, really often, like at least once a week often) stop by after work to see if they have some new things in store.
Ella's Favourite: This is a difficult one because they have so many lovely things in at the moment. But I currently have my eye on another storage basket of Casa! So affordable and really good quality.
Dille & Kamille is a Dutch homeware store started in the 70's in Utrecht but there are now stores all over The Netherlands and Belgium. They not only sell homeware but you will also find plants, condiments, herbs, bath products and more in their shops. It's definitely a kind of vintagey, Scandinavian inspired store. Which is why I probably go there so much. I love this store, so definitely pay a visit if you ever find yourself in the neighbourhood!
Ella's Favourite: I have been looking for a good way to store some magazines in my little bathroom and I think I found the perfect solution at Dille & Kamille. This wooden wall rack, would go perfect in my home!
I have been a little obsessed with VT Wonen ever since I got my own little apartment. VT Wonen is not only an interior design magazine but they also have a webshop with an amazing range of brands. Honestly, I spend way too much time browsing through their shop. There is something in my basket at all times. My favourite brands that they sell: Casa Vivante, Bloomingville, Madam Stoltz, LaForma, Hkliving, Nordal, FEST Amsterdam and Serax. Just to name a few.
Ella's Favourite: The new Bloomingville collection looks amazing!
I was introduced to Westwing a few years ago, through a tv advert. I knew of the store but they didn't deliver to Belgium so I didn't bother looking at their stuff. But I am so glad they now do and have made quite a few purchases since. They have 2 webshops. One is a traditional store, which they only just launched (WestwingNow). Westwing itself is a webshop that does online sales with discounted homeware and furniture. A sale usually only lasts a few days and there is a limited quantity of every product. So you better be quick if you really want to get something before someone else buys it and it is sold out. Delivery takes a little longer as they only ship everything once the sale is finished.
Ella's Favourite: WestwingNow has this beautiful gold & pink armchair in their collection. It is a little out there but I think it looks absolutely wonderful and I wish I could afford it!
Hema, Hema, Hema, a good old favourite of mine. This Dutch chain stores sells everything, from homeware to clothes to makeup. When I was a teenager, I used to love the store for their wide range of stationery and have gotten quite a few homeware bits from them ever since I first moved out. I only wish they would bring more new collections out, I would love to get myself some new homeware bits Hema!
I have previously mentioned Maisons Du Monde on Ella Was Here and haven't stopped loving their wide range of furniture since. They have since opened quite a few stores in Belgium and I am so pleased with this evolution. It's definitely easier to imagine how a product would look in your home when you get to see it beforehand.
Where: online and in stores. Ships to most European countries.
Ella's Favourite: I have my eye on this lovely teak bench for in my hallway. I have been looking for something natural looking but also functional. And I think this bench might be it.
Pictured: Meraki scented candle Sandalwood & Jasmine, all white cups and mugs are from Dille & Kamille, glass vase Thrift Store, dried weath Dille & Kamille, wooden coasters CASA, white pot with wooden top Habitat, wooden spoon Dille & Kamille, indoor plants and pots Intratuin, glass vase round Serax, small wooden bowls Habitat, candle IKEA, white spoon CASA, Spices Le Monde En Tube, small grey pot HK Living.
I might end up doing a furniture and homeware wishlist post soon as I really loved listing all of my current favourites. Do let me know if you are interested in that!
What are your favourite homeware stores?


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Spacetoon/Anime Night with Nour Khan ROOM Art Space & Cafe 10 Etehaad Al Mohamin, Qasr an Nile
sat27apr9:30 pmsat11:00 pmSpacetoon/Anime Night with Nour Khan9:30 pm - 11:00 pm ROOM Art Space & Cafe
Room will be hosting an acoustic night of Spacetoon/Anime Covers by vocalist Nour Khan. She will sing in Arabic, English & Japanese. Nour is an Egyptian vocalist. She had a passion
Room will be hosting an acoustic night of Spacetoon/Anime Covers by vocalist Nour Khan. She will sing in Arabic, English & Japanese.
Nour is an Egyptian vocalist. She had a passion for singing since she was 8 years old but in 2010 she started developing her singing techniques all by herself.
In 2012 she participated in "Sing Egyptian Women" competition which was held by "The US Embassy in Egypt" where she made it to the top 16 and performed live at El-Sawy Culture Wheel. In the lead up to this concert, she among the sixteen finalists attended several workshops led by industry experts like "Neveen Allouba"
In September 2013 she made her first original song "Ghorabaa" with her friend Abdallah Mohamed who arranged the music. The lyrics are from the famous poem "Ghorabaa" by Samih al-Qasim. The song became a hit and has now more than 4 million plays on SoundCloud.
In May 2017 she released her second called "Layta Li" with her friend Abdalla Mohamed as well who arranged the music. The lyrics are also from a famous poem by Aboul-Qacem Echebbi.
In October 2017 she started studying Opera singing at Cairo Opera House. Her teacher is the great Tenor singer and vocal teacher Sobhy Bedeir.
In early 2018 she decided to form a new Arabic rock band called Qafiya. They released their first single "Eskoni Ya Jerah" on November 20th and they are currently working on their first EP.
To know more about her, follow her on:
SoundCloud: https://soundcloud.com/nourkhan
Anghami: https://play.anghami.com/artist/4164064
Facebook: https://www.facebook.com/nourkhanne
Twitter: https://twitter.com/nourkhanne
Instagram: https://www.instagram.com/nourkhanne
Musicians performing at the concert:
Guitarist: Amr Atef
(Saturday) 9:30 pm - 11:00 pm
ROOM Art Space & Cafe
10 Etehaad Al Mohamin, Qasr an Nile

redpajama_set_name: RedPajamaCommonCrawl


That's because the sky really is falling this time--thanks to some aliens.
...as shown by CNET News.com reporter and sometime eyewear model John Borland.
"Chicken Little" is being released in an updated, digital 3D technology that's drawing buzz from directors and theater owners.


Pavlos is a male name for Greek people, although Pavlos is actually a Roman name, originating from the latin word Paulus, which means humble. The name today is used to commemorate Apostle Paul – Pavlos is the Greek respective of Paul.
Pavlos is a very important name for the Greek Orthodox Church, because it refers to Apostolos Pavlos (Apostle Paul), the important leader of the early Christian Church. The story of Apostle Paul is described in details in the Acts of the New Testament. The larger number of epistles in the New Testament are authored by Paul.
His name was Saul, but when he became a follower of Christ and a Christian himself, he changed his name to Paul. Although during the years of Christ Paul was not much different from any other Apostle in terms of actions, after the Crucifixion, Paul decided to spread the word of Christ and God and he traveled in many places on earth preaching. This is why he is considered the Apostle of the Nations.
Apostle Paul is a vital personality for the Greek Orthodox Church, because the Orthodox dogma is based on the preaching of Paul – while the Catholics follow the preaching of Apostle Peter. In any case, though Paul is a significant person for Christianity, but also quite interesting for those intrigued by the dark side of several events. According to many sources, Paul was actually the first person who "disagreed" with the preaching of the contemporary Christians, providing his own view and theory on the religion.
Due to the popularity of St.Paul, the name became popular among the Christians and especially the Greeks, who have been naming many children with the name Pavlos or Pavlina in the female form.
Pavlos doesn't have many nicknames; the most known ones are Paul, Pavlikos and Poulikos, with the last two mostly common in the rural areas of Greece.
Pavlos is a quiet person and dislikes fights and arguments. He is very organized and look self restrained, but the truth is that he is quite spontaneous, especially when he wants something a lot.


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Why Must Cannabidiol CBD Oil Supplements Be Used In Wingate Montgomery, IN?
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The way CBD interacts with the body is via the endocannabinoid system or endogenous cannabinoid system (ECS). The endocannabinoid system was initially discovered during the late 1980's regulates the homeostasis of your body, or general balance state, which impacts functions including immune response, pain, hormone regulation, appetite, sleep and mood. Exactly like an acrobat up on a higher wire, our surrounding environment impacts our regular balance. This can be corrected through the endocannabinoid system by mediating the body's reaction to keep things level.
The endocannabinoid system can be found in all mammals and is comprised of countless various cannabinoid receptor sites that are primarily found through the defense mechanisms (the CB2 receptors), central nervous system (the CB1 receptors) and brain that act inside the neural communication.
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The non-psychoactive of cannabis and naturally low-THC hemp plant, grows in many different countries all over the world and then gets imported to the U.S. for usage in foods, supplements, building materials and textiles.
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With scientists, legislators, families have grown to be more aware of potential of hemp CBD oil and cannabidiol, provides the supplement marketplace using a game-changing solution, which gives all of the benefits that CBD has, minus the high that marijuana offers, that happen to be counted on by a large number of individuals on a regular basis.
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text:
package com.iv.arrowcomponents.ui.viewholder;

import android.view.LayoutInflater;
import android.view.View;
import android.view.ViewGroup;
import android.widget.TextView;

import com.iv.arrowcomponents.R;
import com.iv.arrowcomponents.adapter.ArrowAdapter;

/**
 * Created by ivazhnov on 12.10.15.
 * All rights reserved. Copying is forbidden,
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public class ViewHolderDefaultHeader extends ViewHolderBaseList<String> {

	TextView title;

	public ViewHolderDefaultHeader(View itemView) {
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redpajama_set_name: RedPajamaGithub


Last September Amazon opened a smart home section on their American site. Now Amazon UK have just launched their own Home Automation store too.
Split into sections like Energy & Lighting, Monitoring & Security, Entertainment and Appliances, this pulls all Amazon's home gadgetry into one easy-to-browse place.
Be the first to comment on "Amazon UK Launch Dedicated Home Automation Store"


text:
Lyndy Summerhaze
A re-launch of William Shakespeare in his true light, and an expose of us in our 'reality of life' and the situation of world 'as it is' – this book surpasses the best thriller you ever read. Fraught with wild tales of debauchery, romance, kingdoms in turmoil, alchemy, life and death in all its guises, or 'life as we still know it', the brilliance of Shakespeare is uncovered in a way you would never have imagined. Dr Lyndy Summerhaze pulls back any veil of mystery surrounding his work to reveal the pearls of truth actually presented.
Ever wondered why over centuries Shakespeare's plays has been so loved, read, studied, watched, still used in every school curriculum . . . they map in detail The Ageless Wisdom and our ongoing dilemmas as a society and a humanity and provide a key to unlocking the wisdom that we can apply to every situation imaginable.
'All the world's a stage, and all the men and women merely players' . . . never has a truer word been spoken.
~ Jenny James
WHAT PEOPLE ARE SAYING . . .
Since its publication over four centuries ago, Hamlet has been lauded for its dramatic insights into the 'human condition'. These are principally expressed through the eponymous Prince's introspective soliloquies.
What is laid bare in Lyndy Summerhaze's dissection of the play is that the play's (novel at publication) 'psychological revelations' are made unreliable by the very fact that Hamlet - written as an 'highly individual character' - is caught in the existential creations he so despises. While the drama entertains, the espoused 'insights' further the delusion. How so?
Ultimately Hamlet's awareness is filtered by his ensnarement through identification, which Lyndy outs as 'thinking he thinks' but that could also be described as insufficient presence to truly sense the malign energies or forces at play and thus be immediately responsive - rather than time-bound and led by his thoughts, beliefs and particularly his ideals.
Lyndy devastatingly draws (to lovers of such theatre) all the current parallels out of this 'cult of personality' and its disastrous effect on the whole of society.
Attachment to self and its 'glories' - its 'fifteen minutes of fame', devotion to the intellect again with its self-referential obsession, the primacy of success, the ignorance of the energetic basis of Creation's smorgasbord, the scornful dismissal of those sensitive to the essential truth that Lyndy so clearly states: '(we) are vehicles of expression for either Heaven or....' has brought us all to our current state - by which, late-middle-ages Denmark looks positively halcyon.
As Lyndy again and again reminds us (unlike any other critical analysis of Hamlet/Shakespeare known to me) - one's alignment to Creation and its blandishments is a one-way ticket to a bespoke and customised version of Elsinore at duel's end.
Or as Lyndy writes: 'we can align to the Soul, to Heaven, then comes birth of the glorious Son of God'.
If the play Hamlet is scripture to the literati, Lyndy's brilliant exegesis on this icon and her acknowledgement of the inspiration she gained from Serge Benhayon offers perhaps the shortest way out of such a desert.
~ Alan Johnston
Reading the works of William Shakespeare is a lot like looking in the mirror.
You read into the plays what you want to read, just as when you look into the mirror, you see what you want to see.
And that's ok for the general public who pay their money to see the plays, just as it's ok for the mirror obsessive to misinterpret exactly what it is that they are seeing.
But what of the critics? Those who spend their hours seeking out the hidden meanings and veiled references in the texts. Why are these erudite scholars – many of them authors themselves – so often at one in their interpretations of the goings-on in the plays: or when there is occasionally dispute as to the meaning, the alternative viewpoints are equally wide of the mark?
The answer to that may be entwined in the question as to why these 500-year-old plays continue to fascinate us in the 21st century . . . and why an endless stream of people queue for hours to spend a few short moments with the Mona Lisa.
Why are the plays not dated? Why have the public not moved on from a Renaissance portrait?
The learned critics and modern interpreters may simply not know the answer to that question, and like the curators at the Louvre in Paris, who jealously guard a cash cow when they have one, they might just not care. As long as the public continue to flock in.
There is however, one person who does make a lot of sense when she talks about 'The Bard' in her brilliant reviews of his works that are collected together in this book – and that answer the aforementioned burning questions as to their continuing popularity.
These are, in short, timeless classics. Ageless if you will. Viewed from the perspective of everyday reality – as we know it – they make only superficial sense, with a few jokes and horror scenes thrown in to spice them up for the masses.
But Lyndy Summerhaze, the author of this tome, is not at all deceived by the mayhem and skulduggery that is no more nor less than a transparent recounting of the insane manner in which we live and conduct ourselves, and the bloodbaths that result.
With the acuity of the finest razor, each play is thoroughly dissected to reveal that William Shakespeare was himself a masterful observer of the human condition – and more so, that this condition is entirely self-inflicted, just as it is needless.
Armed with the understanding that the human body constitutes a battlefield for unseen forces, Lyndy Summerhaze exhibits a profound understanding of what Shakespeare was truly offering his public. She stands with a small group of people who recognise that the time has come to resolve this battle and to move on from the torments that have plagued mankind since time immemorial.
For the student of Shakespeare, this book is absolutely essential reading.
For the student of life, it is priceless.
~ Andrew Baldwin
Lyndy Summerhaze is the ultimate scribe for William Shakespeare. With her profound love and understanding of Shakespeare's work, she effortlessly decodes the language and hidden meanings within the plays, to bring to life the timeless insights that are as relevant to our lives today as they were hundreds of years ago.
If you ever thought that you don't like Shakespeare, or that the language is too complicated, wait till you have read this book. Flashbacks of high school English studies will melt away as the richness and depth of the plays are unfolded with a simplicity and joy that makes them universally accessible to all.
I studied King Lear in Year 11, and although I loved Shakespeare I didn't enjoy the play at all. I found it so grim, so grey, and so bleak. To make matters worse, we were required to interpret the play through different lenses of thought, all of which only polluted and obscured the magic and insight that the play was offering, rather than drawing the meaning out. Lyndy's chapter on King Lear is the complete antidote to this. She beautifully represents why the play is so necessarily grim while also breathing colour into aspects of the play that I had not been aware of before. Her understanding of the role of Cordelia is exquisite. The depth of love and truth that the King's youngest daughter represents is explored in full, blowing away 2-D interpretations of virtue and benevolence, to unveil a strength that is unshakeable and does not play ball with the lies of the world, yet remains ever loving and understanding with no judgement – no matter what the cost.
Meanwhile, the behind-the-scenes desire for individuality and attachment that run all the other characters in the play, and how they are the architects of their own misery, is masterfully shown. Lyndy's take on King Lear was an absolute joy to read. It was so vibrant it was like watching a movie, except so much richer in its insights. Highly recommended.
~ Jonathan B, NSW
Within her elucidating rendition of Twelfth Night Lyndy Summerhaze reveals the limitations, corruption and stagnancy of our world, which is mirrored in the world of the play. Shakespeare's language is energetically explored as a means of revealing universal truth, if we but had the senses to receive it. But thankfully we now have Summerhaze, who magnificently does this for us, pulling back the curtain and illuminating the intrinsic wisdom within the play. A key revelation presented, that turns our understanding of gender on its head, is the hermaphroditic essence of love that is at the core of each human being. Indeed, her discussion of abuse, gender, relationships and love is a pioneering thesis that is nothing short of brilliant.
~ Anita Czoch, writer, composer and teacher
Don't pick up this book unless you are ready to acquaint yourself with Shakespeare in a entirely new light. Lyndy Summerhaze skilfully penetrates the hidden meanings within some of Shakespeare's most loved plays and reveals for the first time what you may never have intuited or imagined. Take A Midsummer Night's Dream for example – a play that may be very familiar but you will never have never read an analysis quite like this well written and informative commentary in which Lyndy Summerhaze weaves together the insight of the Ageless Wisdom with the depth and wit of Shakespeare, all the while unpacking what he was hinting at with his exposé of the hidden and dark forces that control and manipulate the behaviour of human beings from behind the scenes, without anyone realising that they are being played like puppets. We may laugh at the foolish antics of the distraught lovers both human and faery, and the stupidity of the Athenian tradesmen but are we not in the same boat? This and so much more depth and wisdom is offered, which makes reading these writings a very enriching and rewarding experience and one that will give you much to ponder upon.
~ Josephine Bell
If you ever felt that Shakespeare held a depth of wisdom that you couldn't quite decode, that felt just out of reach of your full understanding, then this book is a must read. This is the kind of treatment of Shakespeare that I wish I had access to when I was studying at high school and University. I have to admit I have never been a huge Shakespeare fan. But when I read Lyndy's elucidations on The Tempest I realised that it was never Shakespeare I didn't enjoy, it was the reinterpreted and projected meanings imposed by intellectuals about what the plays meant that never seemed to resonate with me. This book provides a truly multi-dimensional view of Shakespeare lit up by the Ageless Wisdom of our modern times, like a painting that has been hung in a dimmed room now finally illuminated by the same source of light that it originated from. The only source that can truly shine a light back on it. This is Shakespeare. Honoured and fully restored.
~ Rebecca Baldwin
You can purchase the book via GOLDEN MEAN BOOKS PUBLISHING
Copyright © 2021 by Lyndy Summerhaze unless otherwise stated. All rights reserved. Photography by Clayton Lloyd. Website by Emanation Media.


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The Dark Secrets of Thailand's Military
One bold woman has thrown the institution into controversy in her pursuit of justice.
By Pavin Chachavalpongpun for The Diplomat
Credit: Flickr/Prachatai
The Thai army has is once again mired in controversy after a series of young cadets were found dead while undergoing military training. To worsen the situation, in the latest case, the niece of a deceased cadet was charged for damaging the reputation of the army when she tried to reveal the brutalities that have been going on inside the barracks.
This week, Naritsarawan Kaewnopparat, currently an officer working for children's social welfare, was arrested for defaming the army through her Facebook writings. She accused the military of protecting "certain peoples" in the army who were responsible for the violent murder of her uncle, Wichian Puaksom, who died in the army camp in June 2011. Though she was subsequently released on bail, the case against her remains and she has exposed what is a wider problem in Thailand.
A Dark Tale
Wichian volunteered to serve in the army and was stationed in Narathiwat Province in Thailand's Deep South. He was caught running away from the training and, according to Naritsarawan, was tortured to death. Found guilty of abandoning his duty, he was slapped in the face several times and dragged on concrete floors naked. His body and face were crunched by several higher ranked soldiers, who also also stomped on his neck, stabbed his upper legs with sharp bamboo poles, and kicked him in the testicles.
Though this would clearly be regarded by any outside observer as inhumane, this is actually not unheard of in Thai military culture. Within the military, there exists a kind of punishment, known in Thai as "som," which involves physical brutal attacks against victims.
The injury caused to his body was so severe that he was sent to an emergency room in a Narathiwat hospital, but even the doctor could not save him. All this time, his family was kept in the dark about what went on. When the news of his death broke out, the military attempted to silence the family by offering compensation of 7 million baht ($200,000), but the Puaksom family rather wanted justice for their son.
Naritsarawan, then just a university student, embarked on a journey of discovering the truth about her uncle's death. She wrote numerous complaint letters and petitioned to the highest authorities in the army, including General Prayut Chan-o-cha, the current prime minister who was then the army chief, to investigate the case and bring the culprits to justice. But all her efforts seemed to fall on deaf ears.
Apart from the fact that her repeated calls for justice for Wichian were denied, Naritsarawan and her family have also continued to be traumatized by intimidation and threats. Her family was warned by the authorities not to dig up the case lest their own lives be taken. Once, someone fired a gunshot into her house, though fortunately nobody was injured.
Naritsarawan's grievances became the subject of public attention again following the recent death of another military officer, Kittikorn Suthiraphan. Kittikorn was also killed in an army camp in February this year. The tragedy reminded Thais that the culture of "som" within the military has not been abolished, contrary to what the army had said to Naritsarawan about her uncle being the last case of its kind. Feeling betrayed, she began to write critically on Facebook about the dark secrets inside the military, including its culture of impunity as well as its aversion to being transparent to the rest of Thai society.
Since the military staged a coup overthrowing the elected government of Prime Minister Yingluck Shinawatra in May 2014, Thailand's key institutions have gradually become militarized, partly because of the benefits from such militarization but also partly because of the reality that the military has become fused with the state.
Within this context, there have been numerous cases involving wrongdoings or irregularities on the part of the army or groups or individuals within it. Yet these incidents have been either buried or fiercely defended by the coup makers. For example, Rajapakdi Park was sullied by a corruption scandal involving the army, even though it denies its involvement up till today.
Top military elites have also exploited their position to promote their relatives, friends, and allies. Prayut's brother, General Preecha, was promoted to the position of permanent secretary of the Defense Ministry and a member of the National Legislative Council. Preecha also appointed his son to serve in the army too. Deputy Prime Minister General Prawit Wongsuwan's brother, Patikom, was handpicked to head the Department of Corrections. The media in Thailand is not allowed to discuss the promotions of these powerful figures.
Naritsarawan's tireless pursuit of justice should not be seen as just an attempt to seek redress, but also an opportunity to expose the dark secrets of Thailand's military which is at the root of many of the country's problems. Her case is proof that key institutions have been militarized, including the judiciary, which has been closely working with the army to defend their mutual political interests.
The deaths of the two cadets may suggest a series of troubling incidents within the military. But they also symbolize a larger problem in Thailand: a country becoming a lawless state ruled by ruthless military despots.
Pavin Chachavalpongpun is Associate Professor at Kyoto University's Center for Southeast Asian Studies.
post-coup Thailand
Thailand civil-military relations
Thailand human rights
Thailand military
Thailand military coup
Thailand military culture
Thailand post-coup election
Thailand torture
Thailand's Junta Chief Warns Against Election Rush
Thai premier cautions that underlying problems need time to be solved.
A New Era of Intolerance in Thailand?
By Shawn W. Crispin
Rising nationalism after the king's death could signal worrying days ahead for the country.
Torture Under Thailand's Military Junta
By Mong Palatino
A new report exposes the extent of the practice under the current government.
Thailand's New Constitution: A Blow to Rights?
Despite the approval of the Thai charter, its content remains worrying.


text:
'Superbad' Forged: The place Are They Now?
Nonetheless humorous! Jonah Hill, Emma Stone and extra Superbad stars have continued with their thriving careers because the comedy movie's 2007 premiere.
The approaching-of-age film, written by Seth Rogen and Evan Goldberg, was based mostly on the duo's expertise rising up in Vancouver, Canada. The onscreen besties — performed by Hill and Michael Cera — launched into a collection of hilarious escapades that concerned partying, romance and extra teen tropes.
The artistic crew behind the movie initially feared the content material could be an excessive amount of for some viewers. "I believed that once we confirmed Superbad to audiences, we might begin an ongoing debate about how soiled ought to the film be," producer Judd Apatow instructed Entertainment Weekly in August 2007. "And on the very first screening, no one within the viewers had any challenge with something within the film within the numbers that might make you modify it. I couldn't consider it. I believed we might be debating so many set items and language and reducing issues. And there was nothing."
Hill recalled that he and Cera "weren't allowed to go to the primary take a look at screening in case one thing went horribly mistaken." The Moneyball star added: "I keep in mind the second everybody referred to as me and emailed me on the similar time. Judd despatched me just a few emails, one being like, 'It's loopy, it's superior. Everybody cherished it.'"
The actors have been inspired to improvise on the set — after a lot preparation. "We did rehearsals for a month beforehand the place we'd hang around at Seth's home and we did a bunch of desk reads," Cera defined. "I felt like I knew it rather well, and we have been so snug round one another."
Hill, for his half, leaned into the chance regardless of the stress. "I believe numerous it's being so scared to not do it, you simply do it," he mentioned. "If somebody put you in that place and there's cameras round and also you didn't do it, you'd really feel so s—tty."
Scroll via the gallery under to seek out out what the solid of Superbad has been as much as because the film's launch (trace: they're killing it in spite of everything these years)!
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Today is November 11, which means it's the 11th day of IMOF!
1. Two close friends both have birthdays this weekend and mine is the last weekend, so we always end up having a shindig every weekend of the month. We decided we just as well keep that up. Almost 10 years later, here we are.
2. My birthday always gets lumped in with Christmas and Thanksgiving. Sometimes I call it Chrisbirthgiving. Or Thanksbirthmas.
It's also the time of year where I start planning my off-season and next year's training, but that is a topic for later in the month.
My favorite thing about this time of year is to watch everyone reflecting on what they're thankful for, since Thankyougiving is right around the corner. This year I am more thankful than ever about everything I have. Sometimes - and this sounds silly - when I'm getting ready for work or driving to work in the morning, I hang onto my steering wheel and feel thankful for my car. I open the lid on a jewelry box and feel thankful for that necklace or pair of earrings. I put on that pair of shoes and be happy that I have a choice of them.
So here is one of the – possibly thousands of – things I am most grateful for: the people in my life.
I have always struggled with other people's opinions of me. I am never sure what to censor, so I feel like I'm constantly holding back. When I finally find people that I feel I can tell anything - unedited, unfiltered, uncensored - I feel like I'm released from a lifetime of shackles. I try not to word-vom all over them, but sometimes it happens. I have to remind myself not everyone wants to have a stream-of-consciousness, philosophical conversation about your inner thoughts every day, or even every week or month.
And I tend to hang onto people long past the natural evolution of a friendship, or after years of being diminished or guilt-tripped or pissed off, because I feel so happy to have found that person I can be ME with. I will stick up for someone, even if they do something really crappy. I believe in second chances. And third. And fourth. I have given someone "chances" for double-digits' worth of years. And since I am even bothered when someone I don't know (or care to know) has a bad opinion of me – well, then when someone who really knows me decides to form a certain opinion about me, it cuts me to the bone. I have learned in both my blog and my real life to pull back on the sharing a little, but it is hard to break yourself of natural habits.
I think this is why the handful of close friends I have are so important to me. They know all my ugly. They know all my good and bad. I am so happy to have people in my life who always make me feel included and "heard." Who support me when things matter to me. I mentioned that the people around me made it possible for me to go to New York after everything fell apart this year. That is not something I take for granted. Not even for a second.
Having good people around doesn't mean that those people always agree with everything you do, either. Sometimes good people challenge you to be better, think before speaking, or consider a new viewpoint. But "challenging" someone and bullying them are different; publicly chastising someone and privately advising them are also different. You need someone to ask you the hard questions from time to time; you don't need someone to challenge your right to feel a certain way every time you share your feelings.
Anyway, I think you get the point here. I am surrounded by amazing people.
Let me just put this out there: there is not a damn thing wrong with wanting, working for, or earning a PR. And there is not a damn thing wrong with not wanting, not working for, and not achieving one, either.
Some people are motivated by doing their best. Others are just along for the ride. There is nothing wrong with either viewpoint. I think what is important is not to get hung up on it - either way. Can you talk about your goals (or lack thereof, it that's your thing)? Absolutely. I believe speaking your goals into life motivates you to attain them. I can tell you, as an industrial psychologist, that goals are important as long as they are specific, challenging, and attainable.
But, when all is said and done, when the race is over and the dust settles, and that PR didn't come, or it wasn't as big as you wanted, well, then it's time to let it go. It's ok to be a little pissed for a couple hours, or even a couple days - as long as you remember that very few of us are actually doing this for a paycheck. (In fact, most of us are paying to do it.) So that's why I like to say I train to do my best, but race to enjoy the experience.
The reality is: just like in Real Life, no matter how fast you are, good you are, strong you are, there will always be days when someone beats you. Sometimes that person will even be you.
I like to work towards a PR. It pushes me to be my best. But not every day is a good day. And not every race is a PR race. Sometimes - as training, racing, and living chronically ill will teach you - you need to be happy you just showed up. That doesn't give you the right to phone it in - it just means sometimes your best is a little different effort. Sometimes doing your best at something means just having a good time. And that, in and of itself, is also a personal record.


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You may decide to create a blog to reach out to your readers and followers.
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I have LibreOffice Version: 5.0.3.2, English, Build ID: e5f16313668ac592c1bfb310f4390624e3dbfb75 and I'm programming a statistical package for Calc Suddenly, it crashes when I try to assign a macro to a menu. I have assigned macros to new menus before without this problem - it just started happening.
My OS is Windows 7, English.
The same is in Linux Mint, LO version 5.3. In fresh installed version. And that was first what I tried... and BOOOM... Macro security is on lovest level. I am not IT, I am beekeeper... please have that in mind. Thank you.


This module expends Odoo functionality, allowing user to generate barcode depending on a given barcode rule for any Model.
This module use an extra python library named 'viivakoodi' you should install to make barcode generation works properly. 'viivakoodi' is a more active for of 'pyBarcode'.
In all cases, padding will be computed automaticaly, based on the number of '.' in the Barcode Pattern field.
This module is an abstract module. You can configure Barcode Rule, but to enable this feature, you need to install an extra module for a given model. This repository provide 'barcodes_generator_product' and 'barcodes_generator_partner' module to generate barcode for product or partner model.
Alternatively, you can develop a custom module for a custom model. See 'Inheritance' parts.
Finally, you should inherit your model view adding buttons and fields.
Your model should have a field 'barcode' defined.
1. On barcode.rule model, constraint and domain system could be set between 'type' and 'generate_model' fields.


Action Wobbles: Oooops I almost forgot!!
Hi my friends! It's Linda from The Tulip Collector and I am the Guest Designer at Action Wobbles today!! I am glad I checked my calendar again!! I made this cute little card as a reminder and wrote my Design Team Obligations in it!!! This cute little hand with the ribbon around the finger is from Cricut Cartridge Designer Calendar! The papers, trim and buttons are from my wonderful stash of goodies. Make sure to pick up your Action Wobbles today!


Part 10 of our 101 Uses for Rubber Stamps series brings great ideas for stationary projects! Here are a few great ideas from Rubber Stamp Station to help you narrow down what kind of stamp you need for your stationary projects.
Foil printing on business cards and other stationary can get very expensive. Fortunately, it is possible to add your own faux foil printing to spice up your custom stationary . All you need is a stamp pad with metallic ink! Faux foil borders, text, and logos will really set you business card, invitations, and other custom stationary projects apart from the rest of the crowd without costing a fortune.
Product Warning: Trodat stamps were not made to be used with other brands of ink. Using non-Trodat ink may permanently damage your stamp and render it unable to function for its intended purpose.
Are you tired of always stamping with the same color of ink? When you use a Trodat stamp that requires an ink pad, you can purchase multiple colors of ink. But, rather than simply stamping with one color of ink, you can carefully apply multiple colors to create a unique, multicolored impression. All you need is your custom stamp, Trodat ink pads containing the colors of your choice, and a small paint brush for each color. It is best to have one paint brush for each color so you avoid having to stop and wash your brush between colors. Once you have all your supplies, simply take each brush and apply the individual colors where you want them to show up on the stamp. When you are done, test the stamp impression on a piece of scrap paper.
It may take some trial and error to figure out how much ink to apply. You will likely need to apply several coats to each section as the ink will be harder to apply with a brush than it would be by simply pressing the stamp into the pad. The more intricate the stamp design is, the more difficult this technique will be. Bear this in mind when selecting your stamp for this projects. Larger lettering and less detailed graphics will make this project easier.


text:
Tag: Nintendo Wii
Nintendo's Wii Sports Resort Targets Players of All Ages
Sports personalities join in to encourage active lifestyles amongst families
(Singapore, 24th October 2009) – Nintendo Wii is proud to present Wii Sports Resort this weekend (24 and 25th October 2009) at Ngee Ann City, Civic Plaza. The family targeted event signifies the next chapter in the Wii Sports phenomenon.
To promote sporting activity between families and friends, sports personalities participating include Singapore Sportswoman of the Year 2009, National Bowler Jasmine Yeong-Nathan and her brother Jason Yeong-Nathan as well as fellow teammate Remy Ong from the Singapore Bowling National Team. Aide Iskandar, former national captain for Singapore Lions, will be trying out the various sports games with his family.
"I am delighted to have the opportunity to try out the sports games. Bowling with Wii Sports Resort requires accuracy similar to the real sport. This is definitely a great game for family and friends to play with at anytime. The variety of resort-themed sports games will keep me and my brother entertained for hours as we continue to keep ourselves active," said Singapore Sportswoman of the Year 2009, Jasmine Yeong-Nathan.
Wii Sports Resort contains a vast amount of content designed to provide both new and veteran players with fun experiences. The game features an easy pick-up-and-play mechanics that allows players of all ages who have never played any video game before to be able to enjoy. By playing the game together, a family can transform their living room into a Sports Resort as they enjoy the different sports where up to 4 players can play at the same time.
12 sports are featured in Wii Sports Resort: archery, basketball, bowling, golf, table tennis, Swordplay, Air Sports, canoeing, cycling, Frisbee®, Power Cruising and wakeboarding. The new features of the Wii Remote and Nunchuk™ controllers allow players to enjoy greater flexibility. In archery, players hold the Wii Remote vertically like a bow while drawing back the Nunchuk. In Frisbee, players motion with the Wii Remote as though they were tossing a real Frisbee. And while playing wakeboarding, players hold the Wii Remote sideways as though they were hanging onto the end of a tether behind a speedboat.
Sports Resort introduces a new era of motion controls with 12 resort-themed sports enhanced by the included Wii MotionPlus™ accessory. This accessory attaches to the base of the Wii Remote™ controller to bring exacting precision to games that are specially designed for it. Wii MotionPlus recognizes the slightest twist or turn of the Wii Remote controller to bring players deeper into their games. Wii Sports Resort leverages this technology as players escape to a virtual resort and experience all the fun activities of the island setting.
Wii MotionPlus transforms the game-play experience and sets a new industry standard in the motion-based gaming movement that Nintendo pioneered.
Families and sports enthusiasts can visit the Nintendo Wii Experience Tent this weekend to enjoy a mini vacation experience to play Wii Sports Resort. Wii Sports Resort is available at leading video game distributor shops including G3 International and Mega Multimedia , as well as leading electronic or retail stores like Best Denki, Carrefour Challenger, etc.
Over the next two weekends, there will also be more opportunities to try the game at the following shopping malls –
Jurong Point: 30th October 2009 – 1st November 2009
Funan DigitaLife Mall &Vivo City: 13th November 2009 – 15th November 2009
I will be attending the event in the evening at around 5pm. I will twit about this event. Follow me closely at Twitter – twitter.com/weewu


text:
EPA Continues to Claim Glyphosate, the Main Ingredient in Roundup, Doesn't Cause Cancer
The EPA has reaffirmed its belief that glyphosate is not a carcinogen, despite initially concluding the chemical was probably carcinogenic.
(TMU) — The U.S. Environmental Protection Agency (EPA) has reaffirmed their belief that glyphosate is not a carcinogen, despite initially concluding the chemical was probably carcinogenic.
On Thursday, the EPA concluded a regulatory review of glyphosate and found that the most widely used herbicide in the United States is not a carcinogen. While the latest review reaffirms the EPA's previous stance on glyphosate, this conclusion marks the first time the EPA has expressed support for glyphosate after several lawsuits resulted in juries ruling that the chemical was in fact responsible for cancer.
"EPA has concluded that there are no risks of concern to human health when glyphosate is used according to the label and that it is not a carcinogen," the agency said in a statement. A Bayer spokesman told Reuters, "Glyphosate-based herbicides are one of the most thoroughly studied products of their kind, which is a major reason why farmers around the world continue to rely on these products."
Bayer bought Monsanto and their glyphosate-based product Roundup for $63 billion in 2018 and the company has publicly maintained that glyphosate is not carcinogenic.
The EPA's ruling that glyphosate is not carcinogenic contrasts with a 2015 study by the World Health Organization's International Agency for Research on Cancer (IARC) which found that glyphosate may contribute to non-Hodgkin lymphoma. Aaron Blair, a scientist emeritus at the National Cancer Institute and lead author of the study, told Reuters at the time, "There was sufficient evidence in animals, limited evidence in humans and strong supporting evidence showing DNA mutations and damaged chromosomes."
The IARC report was published in Lancet Oncology detailing evaluations of organophosphate pesticides and herbicides. The report concluded that there was "limited evidence of carcinogenicity in humans for non-Hodgkin lymphoma." The evidence for this conclusion was pulled from studies of exposure to the chemical in the U.S., Canada, and Sweden published since 2001.
The researchers found "convincing evidence that glyphosate can also cause cancer in laboratory animals." The report points out that the EPA had originally classified glyphosate as possibly carcinogenic to humans in 1985. The IARC Working Group evaluated the original EPA findings and more recent reports before concluding "there is sufficient evidence of carcinogenicity in experimental animals."
Lori Ann Burd, director of environmental health for the Center for Biological Diversity, told Reuters that a connection between the Trump administration and Bayer/Monsanto "doesn't change the trove of peer-reviewed research by leading scientists finding troubling links between glyphosate and cancer." The cozy relationship between the U.S. government and the BioTech Industry (Monsanto, Syngenta) has been consistent during the Trump, Obama, Bush, and Clinton administrations.
During one of the recent lawsuits against Monsanto, the relationship between Monsanto lawyers and the EPA was made clear. As Alva and Alberta Pilliod fought to prove that Roundup caused their cancer, Monsanto spokesman William Reeves admitted the corporation has regularly communicated with U.S. regulatory agencies regarding reviews of the controversial Roundup herbicide.
During that trial, lawyers representing the Pilliods played video testimony of Reeves acknowledging that Monsanto executives exchanged text messages with regulators from the EPA. More specifically, Reeves was communicating with members of the board that glyphosate was not carcinogenic for humans. The lawyers also gained access to text messages between Monsanto employees and the EPA.
The text messages show that on June 18, 2015, Monsanto scientist Eric Sachs sent a text message to former EPA toxicologist Mary Manibusan looking for help finding a contact in the Agency for Toxic Substances and Disease Registry (ATSDR). Sachs was looking to communicate with someone in relation to the agency's ongoing work developing a toxicological profile of glyphosate, Roundup's main ingredient. The ATSDR had begun working on the profile after the World Health Organization's International Agency for Research concluded that glyphosate was "probably carcinogenic to humans."
In another text, Manibusan told Dan Jenkins, Monsanto's liaison to U.S. regulatory agencies like the EPA, that he may need help "trying to do everything we can to keep from having a domestic IARC occur with this group," in reference to the ATSDR. By June 23, 2015, Jenkins wrote to his Monsanto colleagues alerting them that Jack Housenger, director of EPA's Office of Pesticide Programs, would put a hold on the report. "ATSDR Director and Branch Chief have promised Jack Housenger (Director of the US Office of Pesticide Programs) to put their report 'on hold' until after EPA releases its preliminary risk assessment (PRA) for glyphosate," Jenkins wrote.
When questioned about these texts by the Pilliods' lawyers, Reeves confirmed the text messages were authentic but stated, "I never heard anyone at the EPA say they were going to tell ATSDR what to do."
When considering the EPA's latest conclusion that glyphosate is not carcinogenic in humans, it is important to understand the full context of the relationship between Bayer/Monsanto and the government. The relationship goes back decades and should not be taken lightly.
As Reuters noted regarding the new EPA conclusion, "the EPA judgment could help bolster the case for Bayer as it faces thousands more lawsuits from Roundup users who allege it caused their cancer." Knowing that the EPA and Monsanto are essentially on the same team, is it outlandish to think they might attempt to help Monsanto avoid more lawsuits and multi-million dollar settlements? The evidence makes it clear that Monsanto and government employees have often put their mutual interests ahead of those of the American public.
By Derrick Broze | Creative Commons | TheMindUnleashed.com