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Genome analysis reveals germ cell cancer's distinct roots
Credit : Image by Susanna M. Hamilton, Broad Communications
By Leah Eisenstadt
Primed for self-destruction, testicular cancer cells become drug-resistant as they lose pluripotency factors
Germ cell tumors are growths that arise from reproductive cells, most commonly in the testes. For young men diagnosed with testicular germ cell tumor (TGCT), the most common type of testicular cancer, the news comes with a silver lining: Most patients with germ cell tumors can be cured with standard chemotherapy. Some, however, are not so lucky. Although almost all patients with TGCT initially improve with chemotherapy, a small number will relapse and develop tumors that resist treatment. A very small number of these patients — usually men in their twenties or thirties — will eventually succumb to the illness.
The reasons why TGCT is so exquisitely sensitive to chemotherapy and why it sometimes returns with a vengeance are not well understood. Christopher Sweeney and Eliezer Van Allen, cancer researchers at Harvard Medical School and oncologists at Dana Farber Cancer Institute (DFCI), suspected that a close look at the tumor's genome could help answer these questions and potentially suggest new avenues for treatment.
To pursue these questions in the lab, Van Allen, who is also an associate member at the Broad Institute of MIT and Harvard, first needed samples. Because the disease is generally considered curable, research funding is lacking compared to other cancers, so tissue samples from this rare tumor are scarce. Fortunately, Sweeney had for years been collecting tissue donated by patients with testicular cancer and had slowly amassed a bank of dozens of tumor samples.
Van Allen and Sweeney worked with scientists in the Broad Institute Cancer Program and Genomics Platform to sequence and deeply analyze the DNA and RNA in those samples. Appearing in the December 1 issue of Nature, the study reveals unique genetic and functional changes in TGCT, shedding new light on the molecular roots of response and relapse in this disease and suggesting mechanisms that could be at play in other rare germ cell tumors, like ovarian cancer.
An unusual genome, even for cancer
The researchers sequenced the RNA and protein-coding DNA from nearly 60 tumors in Sweeney's collection and analyzed the data carefully to look for genomic abnormalities. They found that tumor cells acquired mutations in the KRAS oncogene as they became cancerous, but that they maintained working copies of the p53 tumor suppressor gene, which is often inactivated in cancer.
The most surprising insights came when they analyzed the sequence data for copy number variation, looking for extra or missing pieces of DNA in the tumor genome. It was known that germ cell tumors commonly have extra copies of one arm of chromosome 12, but this new analysis revealed widespread genetic rearrangement in the cancer cells.
Co-first author Amaro Taylor-Weiner, a Ph.D. student in Van Allen's lab, explains his surprise upon first seeing the data. "I'm familiar with looking at this kind of cancer genome data, and the results from this tumor jumped off the page," said Taylor-Weiner. What he saw was many large-scale instances of copy number variation scattered along the genome. Entire chromosomes or chromosome arms were deleted or duplicated not just once, but two, three, and four times. "We saw that every chromosome was amplified or deleted in a way that you just don't normally see, which stood out right away. When I saw that, I knew immediately that we were looking at something unusual, even for cancer cells."
Taylor-Weiner and co-first author Travis Zack, now a medical student at Harvard Medical School, combined the results with data from an earlier study of many cancer types and concluded that the extra chromosomes came from separate duplications of individual chromosome arms, not from doublings of the entire genome.
They also observed that the pattern of copy number variation was one of "reciprocal loss of heterozygosity (RLOH)," in which a chromosome from one parent is present in two or more copies while the same chromosome from the other parent is completely missing. "We had stared at this mutation data for a long time trying to find cancer drivers, but it wasn't until we did this additional genomic analysis and looked at copy number data in a different way, that we were able to see something new," said Van Allen. "The variation was totally different from any other cancer type that we've studied."
Chemotherapy tips the balance towards cell death
The copy number variation also pointed the researchers towards a phenomenon known in other cancer types to make cells responsive to chemotherapy, called "mitochondrial priming." In this cellular state, a particular balance of proteins in the mitochondria primes the cell for self-destruction, or "apoptosis," allowing chemotherapy to easily tip the balance towards cellular death. It had been shown that stem cells, which have some similarities to germ cells, have loss of heterozygosity and are mitochondrially primed, so the researchers suspected that germ cell tumors might also be primed for self-destruction, explaining their exceptional response to therapy.
Van Allen teamed up with apoptosis expert and DFCI researcher Anthony Letai to analyze the data Letai had generated in functional studies on testicular tumor cells. They observed that the tumor cells indeed were mitochondrially primed, the first evidence of this mechanism at play in a germ cell tumor.
A major goal of the study was to explore the emergence of drug resistance in TGCT. Fortunately, for his tumor bank Sweeney had selected patients who had samples taken before metastatic cancer develops and after drug-resistant tumors appear, allowing the scientists to investigate the evolution of genetic changes. They observed a continued accumulation of RLOH events in tumors that returned after relapse. Analyzing RNA sequencing data from resistant tumors, Taylor-Weiner found a near-complete loss of expression of so-called "pluripotency markers," proteins that seem to give stem cells their identity.
Taken together, the results suggest that the less stem-cell-like and more mature that testicular tumor cells become, the less sensitive they will be to chemotherapy. An important next step in this research will be understanding what drives the RLOH events, and exploring whether therapeutics can block that factor or reverse the path to drug resistance.
Patient engagement will be key to future clinical studies
Importantly, the study demonstrates the need to reach out directly to patients and encourage participation in clinical research. Although rare, testicular cancer is the most common solid tumor in young men. Future research to further elucidate its molecular inner workings will require lots of samples, so patient engagement will be key.
"Yes, there are very good clinical outcomes for most patients with germ cell tumors, in general, but for the small percentage who will die of the disease, it's tragic," said Taylor-Weiner. "We've shown that studying a highly treatable cancer is still worthwhile, because it can be a useful clinical model for other illnesses and the insights we gain about tumor evolution and drug resistance can be transformative."
Other Broad researchers on the new study include G. Celine Han, Ali Amin-Mansour, Steven Schumacher, Stacey Gabriel, Rameen Beroukhim, Gad Getz, and Scott Carter.
Taylor-Weiner A, et al. Genomic evolution and chemoresistance in germ-cell tumours. Nature. December 1, 2016.
Q&A with Corrie Painter and Eliezer Van Allen: The importance of patient engagement in cancer research
From Dana-Farber Cancer Institute: Scientists identify unique genomic features in testicular cancer
IN BROAD NEWS
A model approach to tackling rare cancers
Taking aim at rare cancer variants
IN BROAD VIDEO
Science for All Seasons: Eli Van Allen
A protein interaction map for finding interesting biology in large-scale genetic and genomic data
CRISPR-based single-cell genetics platform developed by Broad Institute and UCSF scientists enables rapid analysis of critical gene networks
Cancer Dependency Map Consortium accelerates research into tumor vulnerabilities
New method identifies spatial biomarkers of Alzheimer's disease progression in animal model
New project aims to map cellular variation in the healthy human brain
How a mother's microbiome helps shape her baby's development


Giazenshia wrote: You passed seasons of asia for hard, double drum already.
And you passed double drum Kurenai + Doraemon LOLOLOL. Good enough.
So please go and write 八神はやて シャナ on both of your new sticks. Markers are okay.
TaikoDojo will Survive!! somehow.. in its own unique ways..
wow you can play oni double seasons of asia?
It could be Makio...or myself, or someone else... lol.
I'm going to dress differently one day then head to AMK see what happens.
So now got how many double drummer?
Me, Ice, Hayatekazama, wreacko, giaz(edited sorry), Makio...and?
Me, Ice, Hayatekazama, wreacko, gias, Makio...and?
Me, Ice, Hayatekazama, wreacko, gaiz, Makio...and?
Good point though, everyone can double drum, just that not every one like to do it that often... so for those who really like double drumming, shouldn't we have a special title for ourselves?
I double drum air like a penguin flapping its wings. does it count.
gepi wrote: I double drum air like a penguin flapping its wings. does it count.
It counts, and that's the penguin style. You can call it "pengdouwing".
Well anyway mine was when I was a photoshop noob in the past who needs to be guided.
Time to make a new one or maybe not? I wanna make a Hinagiku one but I still don't know how to make moving animations. Stay-still...no problem.
Saving the past with double drums!
sounds alot like bleach to me.. lolx!!! one day we're gonna go to soul society and form a special squad there... LOL! oh and today I met Ice, mitsurugi, wreako24 and AMH..
PS: thanks! I got this siggy from.. er.. um.. actually I kope from some website.. LOL!!!


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Björn Dahlem at Guido W. Baudach
Artist: Björn Dahlem
Venue: Guido W. Baudach, Berlin
Exhibition Title: The Island
Following Im Krypton (2004) and The Milky Way (2007), the Guido W. Baudach Gallery is delighted to present its third solo exhibition by Björn Dahlem. In his work, this Berlin-based sculptor, who was born in 1974, draws thematically in equal measure on physics and astronomy, and on the realms of philosophy, religion or science fiction. Dahlem fuses both concrete and imaginary cosmologies to forge fantastical theoretical models, which, rather than aspiring to depict a faithful illustration of any specific phenomena, allude to the narrative potential of their inherent world views. These complex, frequently abstract intellectual constructs usually find their material expression in fragile, often seemingly weightless structures, fashioned from mundane DIY materials and quotidian items.
In this current exhibition, entitled The Island, Dahlem transforms the gallery into an "architecture of the heavens". Its central object, a crystalline-shaped island, expands meanderingly across the room. Attended by a small rock formation and a "dwarf galaxy", it bespeaks the "grand totality", namely the universe. This island, an elevated plain, harbours various self-contained "holistic world models", presented in glass display cabinets, which thus become interconnected. Common to all these works is that their titles, such as Himmelsglobus (Das Weltall), Milchstraße or Geist, deliberately avail themselves of phenomena or concepts, which by virtue of their universality and high degree of abstraction remain somewhat elusive. This intention is clearly illustrated in the work Geist, which boasts a conglomeration of such terms as "Nebula", "Pseudologia", "Mysterium", "Freude", "Mare Crisium", "Black Hole" or "Materie". The objective of assigning these concrete names is not to furnish a categorical explanation of the work, but rather to reinforce the complexity of levels of meaning in art, to forge a potential openness, which, notwithstanding ostensibly irreconcilable contradictions, strives to "dis-close" the world. For even the island itself, replete with its myriad sub-units, only forms part of a very much larger mysterious universe. What at first glance appears as a representation of scientific phenomena, quickly reveals itself to be a platform, on which Dahlem is negotiating something very different: namely, the hermeneutic notion of achieving an holistic understanding of the world, in which science and art – usually perceived as two distinct systems of knowledge- merge. Science here is applied as an instrument to observe nature, and is possessed of the capacity to highlight the creative principle, the wonder and the beauty of the natural world. From this perspective, the central and titular motif of the exhibition, The Island, can be interpreted as a place of retreat, refuge or a projection, and thus as a romantic topos par excellence. And it is no coincidence that this island – built from polygonal Styrofoam elements – not only resembles a futuristic, spaceship-like, rescue capsule, but is also reminiscent of Caspar David Friedrich's painting The Sea of Ice (The Wreck of Hope) from 1823/24.
The legacy of the Romantic era and its consequential manifestations in the art of the 20th century, such as Joseph Beuys' "extended concept of art", who set out to re-unite the "cold" and the "warm" poles of the world, namely science and art, following a long period of supposed disjunct, are equally reflected in Dahlem's works, as is the modernist project of transforming banal items into something sublime by transferring them into the context of art. Here art and science, creativity and rationalisation coalesce into a harmonious, synthetic entity. Dahlem's presentation in the gallery may be read as a kind of symbolisation of this principle: the crystalline form of The Island reflects the cold pole, the cosmological models in the display cabinets – enshrouded by a mysterious aura – the warm pole. Yet at the same time, they appear in the round as a vast entity, in which the small and the large units continually form a structural complement to each other.
Some group exhibitions Björn Dahlem has taken part in: Fabricateurs d'espaces, Institut d'art contemporain, Villeurbanne (2008) / Vertrautes Terrain – Aktuelle Kunst in & über Deutschland, ZKM, Karlsruhe (2008) / Paul Thek. In the context of today's contemporary art, Sammlung Falckenberg, Hamburg / ZKM, Karlsruhe (2007/2008) / Made in Germany, Kestnergesellschaft, Hannover (2007) / The Uncertainety of Objects and Ideas, Hirshhorn Museum, Washington, DC (2006) / light art from artificial light, ZKM, Karlsruhe (2005) / Return to Space, Kunsthalle Hamburg (2005) / actionbutton, Hamburger Bahnhof, Berlin (2003).
Some institutions and galleries that have hosted his solo exhibitions: The Dream Tank, Alison Jacques Gallery, London (2008) / Helle Materie, Magazin4 – Bregenzer Kunstverein (2007) / The Homunculus Saloon, Engholm Engelhorn Galerie, Vienna (2006) / Strange Attractor, Hiromi Yoshii Gallery, Tokyo (2005) / Solaris, UCLA Hammer Museum, Los Angeles (2004) / Utopia Planitia II, Hamburger Bahnhof, Berlin (2004) / Coma Sculptor, Friedrich Petzel Gallery, New York (2003)/ Orgasmodrom, Galleria Giò Marconi, Milan (2002) / Club Superspace I, Kunstverein Freiburg (2001), Club Superspace II, Kunsthalle St. Gallen (2001), Club Superspace III, Kunstverein Hamburg (2001), Sibirien Forellen Express (with André Butzer), Maschenmode Galerie Guido W. Baudach, Berlin (2001).
Link: Björn Dahlem at Guido W. Baudach
Tags: Berlin, Björn Dahlem, Europe, Germany, Guido W. Baudach
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redpajama_set_name: RedPajamaCommonCrawl


The founding of our Church goes back to 1917. Father Emmet M. Walsh was Pastor of Saint Theresa's Church in Albany. Through the efforts of Father Walsh and Mrs. Horace McDowell, the beginning of the Catholic Church in Moultrie got on the way. We take this opportunity to recognize Mrs. McDowell's zealous efforts in the founding of our church. It was built under the direciton of Father Walsh, who later became Bishop of the Diocese of Youngstown, Ohio. As Pastor of Saint Theresa's Church in Albany from 1917 to 1921, he served Southwest Georgia Missions including Moultrie. Construction of the church was begun under Father Walsh's administration, completed under the Pastorate of Father Leo Kennan, who served from 1921 to 1930.
Father Thomas A. Brennan served the church from 1937 to 1940. Father Michael Manning succeeded Father Thomas Sheehan as Pastor of Thomasville and serve the Immaculate Conception Church from 1940 to 1945. Father John O'Shea served the church from 1945 to 1952. Franciscan Fathers, then, at the request of The Most Reverend Francis F. Hyland, Auxiliary Bishop of the Diocese of Savannah-Atlanta, took the Southwest Territory in 1952. Father Peter C. Sheridan, O.F.M. served as hort period of time. Father Raynor A. Dray O.F.M. served the church from 1952 to 1954. Father Mario served from 1954 to 1958.
Other Priests who have served Moultrie include Father Linus Tigue in 1959. Succeeded by Father Thomas Albert from 1959 to 1962. He was succeeded by Father Frederick Kirchner. Succeeding Father Kirchner in 1963 was Father Thomas Gilbin, follwed by Father Francis Gorman. Father Alan Foran served for a short period in 1978. The Church was transferred from the Franciscan Priests to the Diocese in 1978. Father Richard Minch served that year. Father Francis Barry followed Father Minch in 1979.


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APOCRYPHA CANDIDATE: SLAPSTICK OF ANOTHER KIND (1982)
January 1, 2020 Pete Trbovich	Leave a comment
DIRECTED BY: Steven Paul
FEATURING: Jerry Lewis, Madeline Kahn, Marty Feldman, Pat Morita, Jim Backus, voice of Orson Welles
PLOT: A pair of rich, American, and (allegedly) beautiful parents give birth to hideously ugly and mentally-challenged twins, who turn out to be super-intelligent aliens implanted by a galactic civilization to fight back against the Chinese.
 WHY IT MIGHT MAKE THE LIST: Slapstick tries hard to reach comedy by piling on the surrealism, and ends up just being surreal. This is a time-honored path to mediocrity taken by many a crashed comedy, but adding in the ham-handed Hollywood fumbling of Papa Kurt's source material is the icing on this insanity.
COMMENTS: We're coming up on a review of Slaughterhouse-Five (1972) so I opted to review Slapstick of Another Kind (1982) first, as an aperitif. I choose it for this honor solely because I consider Slapstick to be the weirdest Kurt Vonnegut adaptation I have seen so far. But don't mistake this for praise: this movie is mostly unfunny and a chore to sit through. Reading the book first helps, but only a little.
As bad as Slapstick is, it has several million more miles of hell to plunge through before it lands at the same level of awful as Breakfast of Champions (1999). Slapstick has a coherent and logical structure and attempts to make good use of Vonnegut's novel. Somebody gave at least a fraction of a rat's ass about it. Most admirably, it feebly attempts to capture the spirit and letter of Vonnegut's ethereal humor, sometimes catching a whiff, but often losing the scent. When it fails, it settles for sight gags, prop comedy, and actual pratfalls. It's a mix with a rough texture to choke down.
Caleb and Letitia Swain (Jerry Lewis and Madeline Kahn) are well-to-do glamorous celebrities who give birth to hideous fraternal twins, boy and girl. Meanwhile, China has announced that it's severing all ties with the rest of the human race because the Chinese are just too advanced to talk to the rest of us anymore. Among their other achievements, they've mastered miniaturization, shrinking themselves to inches in height. This news is delivered in an interview between a newscaster (Merv Griffin) and the Chinese ambassador (Pat Morita), who travels about in a fortune-cookie-sized flying saucer. Cut to 15 years later. The twins, Wilbur and Eliza (also played by Lewis and Kahn), mature in isolation, tended to by Dr. Frankenstein (John Abbott) and butler Sylvester (Marty Feldman). The adult twins are truly disturbing to behold and act insane, but this is actually a put-on because they feel people want them to be dumb. The Chinese ambassador, observing through planted spies, pays a call to the parents to inform them that their twins are actually secretly clever and advanced aliens. Since the parents haven't bothered to check on their offspring in fifteen years, this comes as news Continue reading APOCRYPHA CANDIDATE: SLAPSTICK OF ANOTHER KIND (1982) →
1982BewareComedyKurt VonnegutObscure/Out of PrintOrson WellesScience FictionSteven Paul
CAPSULE: THE PLAGUE DOGS (1982)
August 27, 2019 Gregory J. Smalley (366weirdmovies)	3 Comments
DIRECTED BY: Martin Rosen
FEATURING: Voices of John Hurt, Christopher Benjamin, James Bolam
PLOT: A pair of dogs escape from a medical experimentation facility in Scotland and are hunted down as possible carriers of the bubonic plague.
WHY IT WON'T MAKE THE LIST: Yes, the idea of a depressing animated film about the horrors of animal experimentation is a strange one; but, accepting the oddness of the subject matter, Plague Dogs' execution is straightforward.
COMMENTS: "Why do they do it? I'm not a bad dog."
Movie openings don't come much bleaker than this: a black Labrador is swimming in a tank of water, exhausted and struggling to keep his head above water. "I think he's starting to pack it in," says the white-coated lab scientist observing him. The lab's legs stop paddling, his eyes glaze over, and he sinks to the bottom. A hook appears and grabs him by the collar. "I think he went a little longer that Wednesday's test," the scientist observes as the dripping canine is hauled from the pool. He's resuscitated, he's vitals are measured, and he's thrown back into a stone-floored cage with dozens of other dogs in varying states of wretchedness and despondency. The scientists schedule his next trip into the tank for Monday.
If this opening gives you the animal lover in you pause, then realize that it does get better for Rowf the Labrador—but only because it can't get worse than being drowned multiple times a week. With the help of Snitter, a terrier with an ugly bandage duct-taped to his head to cover up the opening in his skull through which the white coats have been digging into his brain, he does escape the hellish laboratory; but life on the outside (rural Scotland) is not so easy, either. Snitter once had a human master, and believes they can find one again; but people treat them as mangy strays and shoo them away. On the edge of starvation, Rowf figures out how to kill a sheep, which of course angers the neighboring shepherds. Meanwhile, the scientists are afraid the escaped dogs will bring them bad press, and so spread the rumor that they are carrying the bubonic plague, which causes the locals to shun the dogs more. They eek out an existence on the edge of starvation with the help of the Tod, a scheming fox who teaches them how to live in the wild in exchange for sheep scraps. But their days are numbered, as a posse inevitably closes in.
As if that's all not bad enough, Snitter has a tragic backstory of how he lost his beloved master. He has flashbacks to his happier days, sitting by the fireplace with his master scratching his head. His heartbreak is squared, when you realize what he's lost. He's also suffering canine madness brought about by all that brain probing—and sometimes, you wish he would stay lost in his delusions. There is no joy and very little humor in The Plague Dogs: the tone alternates between despondent and harrowing. The only spark of hope is Rowf and Snitter's refusal to abandon each other. At times, each decides to lie down and wait for death, only to have the other pick him up to face another miserable day. And yet, you have to give the movie credit; it's uncompromising in its viciousness, and sadly beautiful. Have a hanky nearby; this one goes in the pile with emotionally devastating adult cartoons like Grave of the Fireflies (1988) and When the Wind Blows (1986).
The animation is good, not great, but the artists have carefully studied canine movements to give these two anthropomorphic pooches realistic mannerisms. Snitter helplessly scratches at his bandage with his paw; Rowf, wary, slinks out of his cage. Snitter's two dream sequences are mildly inventive, mixing color with black and white to create doggy dreams.
Snitter and Rowf are a classic outlaw team, outsiders whom we root for against the "legitimate" authorities. On the surface, the movie is a vicious attack on animal experimentation, but our heroes could easily stand for oppressed minorities, or the poor and homeless—anyone who's undeserving of the hardships, scorn and fear society saddles them with. Or, it could be a pure existential allegory about the callous indifference of fortune, which doesn't care if we're good or bad dogs when it randomly doles out its head-scratches or its drownings.
For years, The Plague Dogs was only available in the 82-minute American theatrical version. In 2019 Shout! Factory dug up the extended 105 minute version and restored the film by splicing in two prints. They offer both versions of the film on Blu-ray (although I'm not sure who's interested in seeing the shorter cut), and include a 15-minute interview with Rosen as a bonus feature.
"By dealing mostly with talking, thinking animals as traditional cartoons do, but putting them into strange and harsh circumstances, the film also hammers home its differences from Disney-style animations and their refusal to face real-world problems except in disguised and symbolic form."–David Sterritt, The Christian Science Monitor (contemporaneous)
(This movie was nominated for review by "Jamie," who recommended it "not so much for its content but the fact that this film was actually made (who greenlit a film about a pair of dogs going through hell, and then tried to sell it as an adventure film), as well as its exceedingly nihilistic and morbid tone (all for a story about talking dogs!)" Suggest a weird movie of your own here.)
1982AdventureAnimal crueltyAnimationBritishDepressingFableJohn HurtMartin RosenRecommendedVivisection
APOCRYPHA CANDIDATE: EATING RAOUL (1982)
February 26, 2019 Pete Trbovich	4 Comments
DIRECTED BY: Paul Bartel
FEATURING: Mary Woronov, Paul Bartel, Robert Beltran
PLOT: An urban middle-class couple notices they live in a world where they're surrounded by expendable idiots—so they take to robbing and killing them in order to finance their modest dreams.
WHY IT MIGHT MAKE THE LIST: Every weirdophile has seen this movie and remembers it as a satirical cannibal-comedy, quirky but not on the memorably weird end. It isn't until you re-watch it fresh and recall all the throw-away details—the ketchup on the milkshake, the wine bottle plushie doll in Paul's bed, the Doggie King dog food commercial—that you appreciate the weirdness bursting from the seams in this unique oddball masterpiece.
COMMENTS: Eating Raoul was too ahead of its time. You can hardly find a weird movie fan who doesn't love this movie, and yet it still gets listed near the bottom of great black comedies. Now, we're enthusiastic about Trey Parker and Matt Stone, the Coen Brothers, and even the Monty Python alumni getting recognized as the heralds of modern black comedy. But this movie opens with Paul Bartel getting bitched out by his liquor store boss for not selling the right wines. He is interrupted by an armed robber, shoots said robber dead (deadpan: "Mr. Cray, you killed him!") and then goes right back to chewing out Paul Bartel's ass. Next scene: Mary Woronov is a nurse who goads a horndog patient into finishing his pureed slop hospital food with the promise of hot nursey time, only to switch off with a burly male sidekick for an enema party. None of us filthy sinners love this golden apple enough, and that is why we are not worthy of it.
Our star couple is Paul and Mary Bland, two Hollywood middle-classers who are exasperated, stuck in the me-generation late-1970s swingers era while wanting nothing to do with them. They hate the disco party freaks almost as much as they hate being too broke to pay their bills and open the restaurant of their dreams. When one of these swingers ends up accidentally dead at their hands, a connection between the two issues takes shape, and the Blands decide to turn tricks, seducing swingers to their apartment. Said swingers are expecting a filthy payoff, only to meet the business end of a frying pan to the head. Tutored by "Doris the Dominatrix," who shares her tricks of the trade in between spoon-feeding her baby, the Blands place an ad in the local kink mag, and the suckers bite right away. Might as well take the bread in their wallet, then. Just toss the bodies down the furnace chute, who's going to miss them? It's not like any of these tongue-waggling perverts had parents or anything.
But they do eventually meet one other individual with a clue, Raoul, who runs a suspiciously cheap locksmith service and moonlights as a Continue reading APOCRYPHA CANDIDATE: EATING RAOUL (1982) →
1982Black ComedyCannibalismCriterion collectionIndependent filmMary WoronovMust seePaul BartelSatire
346. LIQUID SKY (1982)
" I'll tell you something, too, that's starting to annoy me about UFOs: the fact that they cross galaxies or universes to visit us, and always end up in places like … Alabama. Maybe these aren't super-intelligent beings, you know what I mean? 'Don't you wanna go to New York or LA?' 'Nah, we just had a long trip, we're gonna kick back and whittle some.'"–Bill Hicks
DIRECTED BY: Slava Tsukerman
FEATURING: Anne Carlisle, Otto von Wernherr, Paula E. Sheppard, Susan Doukas, Bob Brady
PLOT: A tiny alien flying saucer lands on top of the Empire State Building, directly across from the penthouse where drug-scarfing New Wave fashion model Margaret spends her nights bedding partners of both sexes. A German UFO scientist who has tracked this manifestation takes up residence in an apartment across from Margaret, spying on her through a telescope. Margaret's sex partners begin to die off as the aliens harvest the endorphins released during their orgasms.
Slava Tsukerman was a Russian Jew who trained as an engineer before switching to filmmaking. He made a mostly documentaries in the Soviet Union and Israel before emigrating to the U.S. to make features. He began developing Liquid Sky after funding for a sci-fi film that would have starred Andy Warhol and Klaus Kinski fell through.
Co-writer Anne Carlisle, who starts as a fashion model in the film, was a fashion model in real life. Most of the actors were art-scene punks drawn from bohemian casting director Bob Brady's acting classes, and most played some version of themselves.
Many repeat the claim that Liquid Sky was chosen as the title of the film because it was slang for heroin, but according to Tsukerman he encountered the term as a metaphor for euphoria in his research, and junkies only began to refer to the drug as "liquid sky" after the movie became a cult hit.
Made with an estimated budget of half a million dollars, Liquid Sky grossed more than $1.7 million in 1983.
In a 2014 interview Tsukerman announced his intentions to make Liquid Sky 2, but no news has emerged on that front since.
INDELIBLE IMAGE: New Wave fashion shows? Neon sculptures? Flying saucers hovering in front of the Empire State Building? Margaret's fluorescent face paint under a blacklight? All excellent choices. But we had to go with alien-eye-vision, rendered through technology that looks like a cross between malfunctioning army ranger night-vision goggles and News at 11's stormtracker radarscope, but with a Day-Glo color scheme, and often looking like it's peering through a microscope aimed at a dividing zygote.
THREE WEIRD THINGS: UFO/heroin connection; spontaneous hateful beat eulogy; prayer to the Empire State Building
WHAT MAKES IT WEIRD: Liquid Sky is like an alien's attempt at making a film set in the No-Wave Greenwich Village art scene in 1982, if their only previous exposure to movies was the works of John Waters, Ken Russell, and Rinse Dream. Neon, nasty, and occasionally tedious, but there's nothing else quite like it.
Original trailer for Liquid Sky
COMMENTS: Liquid Sky is about aliens, and it might as well have Continue reading 346. LIQUID SKY (1982) →
1982AlienCult filmDrug abuseFashionIndependent filmNew York CitySatireScience FictionSexSurrealismWeirdest!
CAPSULE: KOYAANISQATSI (1982)
August 21, 2018 Shane Wilson	Leave a comment
"These films have never been about the effect of technology, of industry on people. It's been that everyone: politics, education, things of the financial structure, the nation-state structure, language, the culture, religion, all of that exists within the host of technology. So it's not the effect of, it's that everything exists within [technology]. It's not that we use technology, we live technology. Technology has become as ubiquitous as the air we breathe…"–director Godfrey Reggio
"I just shot anything that I thought would look good on film. Shooting bums, as well as buildings, didn't matter. It was all the same from my standpoint. I just shot the form of things."–director of photography Ron Fricke
DIRECTED BY: Godfrey Reggio
FEATURING: the music of Philip Glass
PLOT: The film explores the fragile balance of humanity's use of and interaction with the natural world and the inexorable advance of time through montage, juxtaposing time-lapse and slow-motion photography.
 WHY IT WON'T MAKE THE LIST: Koyaanisqatsi is a landmark motion picture, creating a memorable visual language and utilizing time-honored cinematic techniques in wholly new ways. But it's a strange sort of success: a wordless visual essay which points the finger firmly at its audience to the beat of a musical minimalist icon. An experimental film that becomes a movie lingua franca would normally be an easy call for this list. But, you see, we're kind of running out of room…
COMMENTS: My son was an unexpectedly gracious and patient viewer of Koyaanisqatsi. Surely it would be too much to expect a pre-adolescent boy to be enthused about a movie that opens with ten minutes of canyons and clouds. But he was a game spectator, settling for his own running commentary to keep himself amused. So it was a particular thrill when we arrived at the legendary implosion of the Pruitt-Igoe housing project, leading him to blurt out a shocked "What?" followed by silence throughout the ensuing montage of destruction, and concluding with a pained, "Why would they do that?"
Director Reggio, a veteran of media campaigns to warn of the dangers of technology, couldn't have asked for a better reaction. Given the most common translation of the film's Hopi-language title–"life out of balance"–it's clear that we're supposed to be horrified by mankind's wanton destruction of both the natural world and its own psyche. In fact, it's a little shocking to see how angry contemporary critics were at the film's stance: Roger Ebert called it "an invitation to knee-jerk environmentalism of the most sentimental kind" while Variety described it as "a cynical display of decadence intending to edify and anger to action, but instead alienating with its one-sidedness." More than three decades later, continued environmental peril has placed the judgment of history strongly on the side of the movie. But Koyaanisqatsi remains an effective advocate on its own, Continue reading CAPSULE: KOYAANISQATSI (1982) →
1982Avant-gardeDocumentaryEnvironmentalismEssayGodfrey ReggioMust seePhilip Glass
CAPSULE: CAFE FLESH (1982)
July 4, 2018 Terri McSorley	2 Comments
"Go play in the fallout."
DIRECTED BY: Stephen Sayadian (as Rinse Dream)
FEATURING: Michelle Bauer (as Pia Snow), Andy Nichols, Paul McGibboney, Marie Sharp, Tantala Ray, Dennis Edwards, Kevin Jay
PLOT: "Able to exist, to sense… to feel everything, but pleasure. In a world destroyed, a mutant universe, survivors break down to those who can and those who can't. 99% are Sex Negatives. Call them erotic casualties. They want to make love, but the mere touch of another makes them violently ill. The rest, the lucky one percent, are Sex Positives, those whose libidos escaped unscathed. After the Nuclear Kiss, the Positives remain to love, to perform… and the others, well, we Negatives can only watch… can only come…to … Cafe Flesh…"
WHY IT WON'T MAKE THE LIST: Cafe Flesh is a post-apocalyptic adult film about people who become violently ill from human touch. Generally speaking, adult films are pro-sex, so it is definitely a unique entry in the world of adult cinema. Cafe Flesh was not the only post apocalyptic adult film—it was a popular sub-genre in the 1980s—but I do think it might have been the first. The copious cutaways to the gawking, impotent patrons during sex shows were peculiar, but completely relevant to the plot. As odd as they were they fit in the context of the film. The first couple of performance-art sex scenes were definitely wacky. A lonely housewife is seduced by a milkman in a rat mask while three grown men dressed like babies look on from their high chairs. A guy in a huge pencil headpiece bangs one of the broads in the office while the naked receptionist looks on typing and repeatedly asking "Do you want me to type a memo?" Cafe Flesh definitely teeters on the edge of weirdness, but forced at gunpoint to answer "weird or not weird," I would have to go with "not weird."
COMMENTS: I was a huge fan of Stephen Sayadian's Dr. Caligari and couldn't wait to check out some of his other work. Turned out, his other features were all adult films. My exposure to hardcore films at that time was pretty slim. After checking out Night Dreams and Cafe Flesh, however, I was inspired to check out several other adult titles from the 1970s and 1980s. Sadly, very few were as entertaining or as unusual as Stephen Sayadian's.
The plot verbiage above is taken directly from the film's introduction. The primary focus is on two of the club's regulars, Nicky and Lana, "The Dagwood and Blondie of Cafe Flesh," so dubbed by the club's delightfully sarcastic emcee Max Melodramatic. I gathered from the film's opening statement that the 99% of the population do not only become physically sick by human touch, but are also impotent and couldn't get the job done anyway— although it really doesn't go into much detail on the subject. The post-apocalyptic victims gather together at Cafe Flesh to gawk at art noveau hardcore sex shows. The performers are not volunteers, by any means. Enforcers are out there to flush out sex-positives who are not performing. Angel, a doe-eyed virginal lass from Wyoming, is taken away to do her part in entertaining the 99%.
If you were impotent and human touch made you vomit, would you really want to go to a sex club? They mock the torture of the audience numerous times, the majority of the abuse coming from the aforementioned emcee. Andrew Nichols gives a genuinely standout performance. He delivers his wordy dialog with complete ease; I did not question for a second that he was the emcee of a seedy post-apocalyptic sex club. Also stepping up to the plate and knocking it out of the park is beautiful Michelle Bauer (billed here as Pia Snow, the name under which she made a few adult films at the start of her career). Bauer should be a familiar face to those of us who enjoy 1980s horror cinema. She appeared in a ton of horror flicks: The Tomb, Terror Night, Hollywood Chainsaw Hookers, Nightmare Sisters, and Deathrow Diner, to name a few. I found her character here to be so very likable, I really wanted her to have a happy ending, and indeed she does.
Obviously, considering the plot, the sex is limited strictly to the shows the sex negatives watch. Dripping with 1980s flare and fashion, these stage shows are creative and well-costumed. Stephen Sayadian's films embrace everything that was fabulous and flattering from that decade: sharp angular silhouettes, bold solids, wide black and white stripes. It was all about geometry then—at least, the cool stuff was. I have been suitably impressed with the sets and costumes for all three of the Sayadian films I have seen. The superb synth soundtrack from Mitchell Froom hits every right note; absolutely perfect musical accompaniment. I love this soundtrack so much that I own it. Black and white striped teddies, angular phone booths, sunglass-bespectacled studs, naked ladies in cases—there is just so much to say about the aesthetics here.
Cafe Flesh is a visual treat that oozes the 1980s with good performances and a badass soundtrack. A highly entertaining, tongue-in-cheek, apocalyptic adult adventure.
Fun fact; if you do a Google search for an adult film title, its IMDB listing is usually the first or second hit that will come up. If, however, you are on the IMDB website and search that title, it will not come up at all, unless you use the advanced search feature and toggle the button to "include" adult titles every time.
GoreGirls' Dr. Caligari review (NSFW)
GoreGirls' Night Dreams review (NSFW)
GoreGirls' Cafe Flesh photo gallery (NSFW)
"…in terms of sci-fi pornography set in a post-apocalyptic netherworld, you can't anymore cerebral than this… Sex Negatives force the Sex Positives (the 1% left unaffected by the fallout) to perform bizarre, surrealistic sex acts for their amusement."–Yum Yum, House of Self-Indulgence (DVD)
1982Avant-gardeEroticaExplicit sexPornographyPost-apocalypticRecommendedScience FictionStephen Sayadian
INGMAR BERGMAN'S FANNY AND ALEXANDER (1982)
May 21, 2018 Alfred Eaker	Leave a comment
Fanny and Alexander (1982) was Ingmar Bergman's final cinematic work, although he did make a handful of TV movies afterwards, ending with the poignant Saraband (2003). After decades of desolation within an agnostic cosmos, Bergman keeps Fanny and Alexander in check. Although his obsessions are present, it is sort of an autobiographical release, which results in an immensely enjoyable, epic ((The theatrical cut runs three hours. A 5-hour television version was simultaneously released, as Bergman was understandably reluctant to edit it down. The longer version, with stronger supernatural atmosphere, is preferable.)) coda to one of the most consummate cinema oeuvres, and could even be recommended as a starting point to the Bergman novice.
 As with most of Bergman's films, Fanny and Alexander was received with a degree of controversy. Some criticized Bergman's previous work as overly pessimistic. He also was frequently accused of pretentiousness, and as is often the case, that is a lazy standby label that reveals far more about the critic than the filmmaker. With Fanny and Alexander, Bergman was criticized for catering to populism (John Simon in National Review) and for oversimplification (Dave Kehr and Pauline Kael ). Yet, even the most critical reviews conceded Fanny and Alexander was Bergman at his most accomplished.
There is a pronounced fantasy element to this period family drama, so much so it is one of the few Bergman film covered by Richard Scheib at his genre site, Moria film reviews.
Fanny and Alexander is set at the turn of the 20th century, and immediately establishes its theme of childhood imagination. I would be hard-pressed to name another Bergman film in which children are the primary protagonists. When Bergman takes the plunge, he does so without abandon. The ghostliness of childhood saturates the narrative, the assured pacing, and the artistic design. It opens with ten-year-old Alexander Ekdahl (Bertil Guve) preoccupied with miniature theatrical figurines and a caged rat. The scene is fittingly choreographed, in part, to Robert Schumann's Piano Quintet in F Major (Schumann is possibly the apex of 19th century romantic innocence) and sets the leisurely pacing. Alexander calls out to his eight-year-old sister Fanny (Pernilla Alwin), who doesn't answer—but like most children, Alexander is soon distracted.
Shortly before a dazzling, magically detailed Christmas feast with the Ekdhal clan, Alexander is caught up in a dreamlike state as he imagines an erotic statue suddenly motioning to him, followed by death dragging his scythe.
A Christmas play evokes Mozartian flutes, followed by the entry of uncles Gustav (an amorous Jarl Kulle with a flaming punchbowl) and Carl (Borje Ahlstedt, drunkenly farting on the stairs), and possibly the most beautiful pillow fight ever filmed.
Fanny and Alexander's theatrical grandmother Helena (Gunn Walgren) is the matriarch of the Ekdhal clan, which is filled with irascible actors, rogues, illusionists, and a multitude of servants. The theater life creates a community much like one would find in religion. Both Fanny and Alexander are introverted, but dazzled by the enchanted world gifted them by their theater manager father Oscar (Allan Edwall) and actress mother Emilie (Ewa Froling); but the second half of the film takes a darker turn when Oscar dies unexpectedly. At his father's funeral procession, led by the ultra-patristic and austere Calvinist Bishop Edvard Vergerus (Jan Malmsjo), a bitter and frightened Alexander, out of character, spews obscenities, foretelling the struggles ahead.
Emilie marries Edvard, and soon Fanny and Alexander are subjected to dogmatic abuses ((Bergman's father was a severe Calvinist)). Emilie belatedly realizes that she has married a clerical beast. Oscar's ghost rises (apparently conjured forth by Alexander) to intervene. With the aid of the Jewish eccentric Isak (Erland Josephson) and his warlock nephew Ismael (Stina Ekblad), Fanny and Alexander are smuggled out of their home. Their escape is like a fairy tale, with the children finding a new sanctuary within Isak's surreal theatrical abode. Alexander's ghostly visions serve as a segue into a chimerical coming of age parable, and the demonic bishop's fiery comeuppance may be Bergman's finest moment on celluloid.
While Fanny and Alexander is indisputably imperfect, it is a sensuous epilogue that stands not only as essential Bergman, but essential cinema. A few weeks ago, I declared that once done with my latest round of dipping back into Bergman, I would be forced to shelve any further revisits. After my third summer with Fanny and Alexander, I can most assuredly say that I lied.
1982Ingmar Bergman


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Read articles such as "Festive Fireplaces: Snuggle up in front of the fire this holiday season," "Ring in Spring with a Refreshing Sunday Brunch," "Extreme Living: Tuscan renovation fits family's active lifestyle" and "Green at Heart: Improve five core systems in your home for better energy efficiency and savings will flow." Every story, ad and photograph will excite and inspire your passion for nesting. Find the ideas you need to create your own personal space with House Trends today.
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« Star Wars Battlefront now available for EA Access members
Nintendo Direct 11.12.2015 highlights upcoming Holiday releases, early 2016 forecast »
Zodiac: Orcanon Odyssey launches today for iOS
iOS, News
by Dustin Chadwell
Zodiac: Orcanon Odyssey launched today on iOS platforms for $8.99, featuring JRPG alums such as Kazushige Nojima and Hitoshi Sakimoto behind the development wheel. It's a unique RPG for mobile platforms, with a stylish anime artstyle, and a pretty intriguing combat system.
I've actually played just a bit of the game starting last night, and hope to have a review up next week at some point. So far I certainly think it's worth a look if you're hungry for a worthwhile RPG experience on iPad or iPhone.
Check out the full press release below, and stay tuned for a more in-depth review next week.
East Meets West As Zodiac: Orcanon Odyssey Launches
Gorgeous Award-Winning Premium JRPG Marks First Collaboration between Esteemed Japanese Developers and Western Studio
PARIS – Nov. 12, 2015 – The mysteries of the beautiful land of Orcanon are ready to be unlocked today as Kobojo launchesZodiac: Orcanon Odyssey exclusively for mobile gamers on iOS (iPhones and iPads). The game, already winner of the 2015 Ping Award as best mobile game, and nominated as one of the top titles at Tokyo Game Show 2015 by Famitsu and 4Gamer, is currently up for approval on Steam Greenlight, and will debut on Sony platforms early next year.
With significant contributions from Kazushige Nojima (writer, Final Fantasy VII) as scenario writer, Hitoshi Sakimoto (composer,Final Fantasy Tactics) as composer and CyDesignation, Inc., the Japanese game design and production company led by renowned artist Hideo Minaba, on art direction, Zodiac: Orcanon Odyssey marks the first time these well-known and highly respected Japanese game development icons have collaborated with a western studio.
"Zodiac: Orcanon Odyssey is an original JRPG that was created by people from around the world, brought together by their love for the exploration, quests, scenarios, deep turn-based combat and beautiful artwork found in these types of games," said Kobojo CEO Mario Rizzo. "We crafted Zodiac: Orcanon Odyssey to be as engaging as it is stylish, offering an experience withZodiac that will appeal to all players that enjoy JRPGs – regardless of platform."
Combining some of the best elements of classic JRPGs, Zodiac: Orcanon Odyssey seamlessly combines an engaging storyline and intense battle sequences with freeform exploration, item crafting and a brand-new storyline – all presented with gorgeous, hand-drawn 2D art and accompanied by a full soundtrack.
The game was developed at Kobojo's Dundee, Scotland-based studio with support from the company's Paris headquarters in addition to the contributions from the Tokyo-based developers.
Zodiac is available now for $8.99/ €8.99 on the App Store, and will be supplemented in the future with new episodes planned for future release that add new worlds to explore, new characters to meet and new challenges to conquer.
You can download Zodiac: Orcanon Odyssey from the App Store at https://itunes.apple.com/us/app/zodiac-orcanon-odyssey/id933199580?mt=8.
For more information on Zodiac: Orcanon Odyssey, including new trailers, deep game details and story information please visithttp://zodiac.kobojo.com/.
Tags: ios, ipad, iphone, kobojo, zodiac: orcanon odyssey


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Reducing Health Disparities
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Remove Hurdles to Cancer Care
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Cancer Survivors, Patients and Advocates Wear Suits and Sneakers® to Capitol, Urging Lawmakers to Make Cancer a Priority
COLUMBIA, SC – February 5, 2020 – Today, the front steps of the South Carolina State House were covered in sneakers to remind lawmakers of individuals who had lose their lives to cancer and the work they can do to prevent premature deaths.
Legislators on both sides of the aisle sported sneakers with their suits as they joined cancer survivors and patients from across the state at the Coaches vs Cancer Suits and Sneakers event, part of the annual American Cancer Society Cancer Action Network (ACS CAN) Day at the State House.
Dedicated to blocking cancer before it takes center court in people's lives, Charleston Southern University Women's Basketball Coach and prostate cancer survivor Fred Applin led the rally and shared his personal struggle with the disease.
"I'm a fighter against cancer. Eight years ago, I was diagnosed with prostate cancer and I was lucky enough to have support; some people don't have that. Cancer doesn't discriminate against race, gender or person. We have to fight daily and never give up," shared Applin on the duty of lawmakers to reduce the cancer burden in the state.
This year, 31,710 individuals are estimated to be diagnosed with cancer in the Palmetto State and an estimated 10,780 will die from the disease. But Coach Applin, along with over 50 cancer patients, survivors and their loved ones who gathered at the State House, are working with legislators to change that.
"They have taken the day off and come from all around the state," shared ACS CAN Government Relations Director Beth Johnson, speaking to the passion of the ACS CAN volunteers. "They are cancer survivors who are here to prevent others from the suffering they've had to endure. They are caregivers who have watched their loved ones fight or lose their lives to the disease and want to protect others from untimely death. We are asking our senators to support the Youth Skin Cancer Prevention Act and save the lives of thousands of South Carolinians."
Despite notable decreases in cancer rates nationwide, melanoma, the deadliest form of skin cancer, is the second most common cancer among females ages 15 to 29. Using a tanning bed just once before the age of 35 increases the risk of melanoma by 59 %. Rates increase even more when tanning devices are used before the age of 25.
Current laws fall short of protecting children and adolescents from skin cancer. If enacted, the Youth Skin Cancer Prevention Act would prohibit the use of indoor tanning facilities by all youth under the age of 18, ensure all consumers are properly informed of their risk prior to use, and require all indoor tanning devices to be properly regulated with effective enforcement provisions in place.
The day concluded with a special resolution by the General Assembly officially designating February 5, 2020 as Suits and Sneakers day in South Carolina in honor of the lives lost to cancer and the life-saving work that can be done to reduce the cancer burden in the state.
About ACS CAN
ACS CAN, the nonprofit, nonpartisan advocacy affiliate of the American Cancer Society, supports evidence-based policy and legislative solutions designed to eliminate cancer as a major health problem. ACS CAN works to encourage elected officials and candidates to make cancer a top national priority. ACS CAN gives ordinary people extraordinary power to fight cancer with the training and tools they need to make their voices heard. For more information, visit acscan.org.
About Suits and Sneakers
The Suits and Sneakers initiative, coordinated by the Coaches vs. Cancer program, is a nationwide collaboration between the American Cancer Society and the National Association of Basketball Coaches and the American Cancer Society Cancer Action Network's (ACS CAN) annual Day at the Capitol event to call on the state lawmakers to take steps to reduce suffering and death from cancer.
More Press Releases AboutSkin Cancer and Indoor Tanning, South Carolina
Cancer Patients and Survivors Rally Legislators Virtually Due to Coronavirus
COLUMBUS, OH – The unpredictable and dynamic nature of COVID-19 is no match for the steadfast commitment of the American Cancer Society Cancer Action Network's (ACS CAN) volunteers.
Cancer Advocates Hold Virtual Day of Action Due to Coronavirus
DENVER, Co. – March 12, 2020 – The unpredictable and dynamic nature of COVID-19, also known as the "coronavirus," is no match to the steadfast commitment of the American Cancer Society Cancer Action Network's volunteers.
Mississippi Legislators Turn Their Backs on Teens Again
Statement from Kimberly Hughes, Mississippi government relations director at American Cancer Society Cancer Action Network (ACS CAN), on the state legislature's failure to protect teens from the dangers of tanning beds for five years in a row.
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Q: iOS app update notification / alert I'm getting this by the Apple App Review Board:

Hello,
Thank you for your reply. It is not appropriate for applications to direct users to the App Store through the use of a notification or alert message. On the initial launch of your application, users were presented with an alert message that gives them the option to update the app or be reminded at a later time.
To be reconsidered for the App Store, please remove the update feature from your app. To distribute a new version of your app, upload the new app binary version into the same iTunes Connect record you created for the app's previous version. Updated versions keep the same Apple ID, iTunes Connect ID (SKU), and bundle ID as the original version, and are available free to customers who purchased a previous version.
Resources
To create new versions of your app, please see Replacing Your App with a New Version in the iTunes Connect Developer Guide.
Best Regards,
  App Store Review Team

Previously, this was fine (few months back). And suddenly, when I tried to update my app, this is what they said. But I've been seeing a lot of apps already doing this. So I'm not sure what I'm missing here.

redpajama_set_name: RedPajamaStackExchange


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Letter from Mi'kmaq
UPDATE 2:50 PM: Live feed via Edgar on Veetle
UPDATE 2:30 PM: Latest coverage from Global New Brunswick
October 17, 2013, 7:30 AM – about 700 Canadian police raided the Elsipogtog anti-fracking blockade in New Brunswick. Police have descended on a blockade encampment of members of the Mi'kmaq First Nation, who have been holding a weeks-long blockade to prevent the Texas-based company Southwestern Energy (SWN) from conducting fracking exploration in their lands.
Several people have been hurt and all of the Mi'kmaq Warrior Society has been arrested. Over 200 supporters broke police lines to join the blockade. Reports of rubber bullets fired, reckless use of pepper spray, brutality, all at the behest of SWN.
Help flood the phone lines and emails of SWN to denounce their support for this violence!
Corporate HQ phone: 281.618.4700
New Brunswick Royal Canadian Mounted Police (RCMP): 506-452-3400
Suzane Patles, an Ilnu woman and member of the Mi'kmaq Warrior Society, has called for physical support at the blockade, solidarity actions across Turtle Island on Oct. 18th and a flooding of Kanadian official representatives' phone and mail lines. The October 18th Day of Action is a response in protest to the court injunction that SWN is now enforcing against the encampment.
The compound, where SWN has over hundreds of thousands of dollars in equipment, had been shut down and their equipment seized by local Indigenous peoples. Patles is among many Wabanaki Confederacy peoples asserting their inherent and treaty rights and titles over their territories at an active road blockade since Sept 28th. The HWY 134 blockade is preventing SWN equipment from illegally excavating Mi'kmaq territory and conducting seismic testing in order to begin the process of hydraulic fracturing, or fracking, on unceded native lands.
The road blockade has been estimated to cost SWN over $60,000 a day. The blockade site has the support of Wabanaki Confederacy traditional governance, and widespread community support amongst Indigenous and settler groups. Flood colonial government mail and phone systems with statements of support for the blockade including the demands of the Mi'kmaq Warrior Society. The Warrior Society has issued the following demands to New Brunswick Premier Alward:
Produce all Bills of Sales, Sold, Ceded, Granted and Extinguished Lands for New Brunswick.
Produce documents proving Cabot's Doctrine of Discovery.
Produce the Treaty of Peace and Friendship 1686.
Produce Treaty of Fort Howe 1768.
Produce consents for Loyalists to land in Nova Scotia/New Brunswick.
Produce records of Townships created and consents by Chiefs to allow this.
Produce agreements or consents by all New Brunswick Chiefs who agreed to the Confederation of 1867.
Produce evidence of consents to The Indian Act by all Native Tribes.
Produce records of Trust Funds.
Produce agreements for 4% of all mineral shares of finished products in Canada, except coal.
Produce all correspondence letters pertaining to Numbered Treaties (Promises).
Produce all documents creating border divisions, that divide the Wabanaki confederacy.
Produce the Orders from the Lords of Trade to the Governor of the Colonies.
Follow the action on Twitter: #mikmaqblockade, #elsipogtog, #indigenize, and @stimulator for latest updates.
PDubAllStar
Permanent link to this article: https://tarsandsblockade.org/elsipogtog-blockade-police-raid/


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Q: Smalltalk: how to modify self behaviour I'm porting my favorite Java/JavaScript Mocktito library to Smalltalk. I'm currently at the stage of implementing Spy for stubbing real objects. My problem arises when a spyed object invokes it's own method which is stubbed. Instead of:
self aMethod.

I'd rather want to delegate the call to the spy object:
spyObject aMethod.

Here is a scenario test for the expected behavior:
realObject := RealObjectForTesting new.
spyedObject := Spy new: realObject.
spyedObject when: #accesorWhichReturnsValue thenReturn: 'stubbed value'.

spyedObject accesorWhichCallsSelf.

self assert: (spyedObject verify: #accesorWhichReturnsValue).

Any suggestion?

A: You make your "spy" be a "wrapper" object that only implements doesNotUnderstand: and then swap it for the real object using become:.
The spy's doesNotUnderstand: method will be called for all messages, and you can then e.g. log its argument (which is a Message object) and send it to the original object.
If you browse implementers of doesNotUnderstand: in your Smalltalk image you may find a couple of examples (e.g. in Squeak there is MessageCatcher and ObjectViewer).

A: You could wrap the RealObjectUnderTest's CompiledMethods directly, using the ObjectsAsMethodsWrapper library. This provides a convenient API to install and remove the wrappers, together with some convenient predefined wrappers.
These would intercept self-sends because the wrappers are installed in the real object's method dictionary, and thus may perform arbitrary changes to the message before passing it on to the underlying CompiledMethod.
While my example shows how to memoize a method call without touching source code, it should provide you with the basic knowledge required to mock out method calls.
This particular technique does have a limitation: it intercepts self sends to messages that the class itself defines. So if Foo subclasses Bar and you install wrappers on Foo, you won't intercept messages that form part of Bar's protocol (unless of course you wrap those too).
You won't be able to intercept ifTrue:ifFalse:, timesRepeat or similar messages in a Squeak or Pharo image (and likely in GNU Smalltalk too), because those are not message sends: compile-time transformations inline these message sends into jump bytecodes. (The illusion of a message send is relatively convincing because the Decompiler knows how to untransform the bytecodes back into ifTrue:ifFalse: or whatever.)

A: Smalltalk doesn't have a built-in mechanism for intercepting sends to self, so you'll have to resort to exotic measures.
Probably the easiest way to do it would be to dynamically steal methods from the original object. Your spy would replace the target using #become:, as Bert suggests. Then, when the spy receives a message, instead of forwarding the message to the original object, you'd look up the selector in its class and execute it with the spy as the receiver. The mechanism for executing a compiled method against an arbitrary receiver will vary from dialect to dialect. In Squeak it's CompiledMethod class>>receiver:withArguments:executeMethod:.
As I said, this is pretty exotic—you'll need to generate a custom class for the spy when it's created, and ensure that it has the same structure as the target object so that the compiled methods will work correctly with the new receiver. You'll also have to copy the state of the target into the spy, and back to the orignal object when you're done spying. Finally, you'll have to find a place to stash the target, since the state of the spy has to match that of the target. It's all doable, but it's not simple. You'll be dynamically generating classes and methods, which requires low-level understanding of the system.


My boyfriend brought us out here for a surprise date night. Liz and Nate put on a wonderful dinner for just two and then ended the evening with a delicious dessert and champagne out on the gazebo with all the lights on the tree lit- but the best part was the surprise proposal!! Liz and my now fiancé planned the most perfect evening. The service was incredible and I cannot wait to visit again!
Perfect way to celebrate our 4th anniversary. 3 kids and 2 full time jobs leaves little time alone. Our massage and hot tub relaxing time were perfect. Thank you!
It was nice to stay here!
Celebrating a birthday for my husband. So glad we chose to stay here. We will be back.
Loved the peace and beauty of this place very much. A good place for relaxing and celebrate our 37th anniversary.
Liz a special thanks for understanding about the sugar problem and getting the cheese. Nate thanks for sharing your knowledge and arrow find with us. Super getaway!
Wonderful stay! I asked the woman I have to marry me tonight! Want to say thank you for an amazing proposal place. We are looking forward to returning! We didn't want to leave.
This is our first stay here. We came to celebrate our 8th anniversary! We enjoyed our time here so much! This place is amazing! The grounds and the cabins are so beautiful! It was the perfect little getaway from the hustle and bustle of our daily lives, but also close to home. The hospitality was great! Nate and Liz are amazing! We will definitely come back!
My husband and I got married today! And the choice to stay here couldn't have been ANY better! What a beautiful place! Thank you all for everything! Will see you guys in a year!  Thank you!


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It's hard for me to put into words how good this dip is!
The dreamiest marriage of warm, comforting pumpkin flavours with the nutty flavour punch of tahini.
It's the perfect thing for a cosy night in with friends, or just curling up with on the sofa to watch something captivating.
It's also an excellent reason to use my pumpkin bowls!
Heat your oven to 200C/390f. Toss your pumpkin or squash (it's all gourd!) with a couple tablespoons of olive oil, your chilli flakes and a good sprinkle of salt. Add your garlic cloves.
Roast for 30mins, until soft and browning at the edges.
Once ready, put the pumpkin into a food processor (or you could use a potato masher in a pinch) and squeeze the garlic in there too, like toothpaste out of a tube. Discard the skin.
Add tahini and lemon juice. Blend.
If it's too thick add a splash or two of water to thin it out. Just do this little by little, or you'll end up with a pumpkin puddle.
When you're happy with the taste and consistency, pour into a bowl.
Serve warm with flat bread and chopped veg.
If you're feeling fancy, a drizzle of chilli oil and a few sesame seeds wouldn't go a miss.
Comforting, cosy, spectacularly good for you and made for sharing.
It's the pumpKING of snacks!


Kids will enjoy walking in the rain or shading themselves from the sun under this durable, Giddy Buggy-themed umbrella. Rounded safety tips and child-friendly mechanism make this umbrella easy and safe for children to work by themselves. Kids will look forward to rainy days with Giddy Buggy around to make them brighter!
Dimensions: 24.5" x 3.5" x 2"


Nikhil Kaitwade, Research Head- Industrial Goods Domain at Fact.MR discusses vital aspects determining growth of automotive lifts market.
Currently, the global automotive industry demonstrates a robust high volume growth in sales of vehicles, and this growth is likely to double in the forthcoming decades. This unprecedented growth has hard-pressed OEMs to oversee storage and maintenance aspects of their offerings, to make their products sales-ready. The flourishing growth of automotive industry has posed significant challenges for automakers, vendors, and garages apropos of their limited work places, necessitating deployment of automotive lifts.
The eminence of automotive lifts will continue to grow in parallel with the rising number of garages being set up, making it a viable investment to boost shop safety and combat space issues. Some of the widely renowned lifts used across multiple industry verticals, such as knuckle lifts, in-ground lifts, mobile column lifts, and many more.
Q. How is the growing need of space optimization enhancing appeal of automotive lifts?
Automotive lifts have become an indispensable necessity in case of garages, car showroom, car storage areas, fast lube stations, and so on. This surging demand can be accredited to rising need of space optimization, which remains a key consideration across the shop floor. Automotive lifts make the process of hoisting larger vehicles a lot easier, which is enhancing their visibility in the automotive space. With respect to OEMs, manufacturing vast units of automobiles seek greater utility of automotive lifts, taking into consideration the confined and limited workplaces of manufacturing plants.
Q. What are some of the key attributes influencing purchase patterns in the automotive lifts space?
Durability remains an aspect holding utmost importance among end users of automotive lifts. High productivity coupled with maximized up-time remain one of the key uncompromisable characteristics looked for by end users while making purchases. Top-notch craftsmanship and feature rich designs are further likely to add to the overall product appeal. Last but not the least, versatility remains the game changer. The growth of volume sales of automotive lifts is completely reliable on the versatility offered, which further adds to the overall product value.
Q. What influences will the advent of hybrid/EV vehicles exert in the manufacturing framework of automotive lifts?
The maintenance of hybrid and EV vehicles will be completely different from that of the conventional vehicles i.e. the maintaining costs will be unreasonable and can be highly expensive. In case of hybrids and EVs, owners have to take them to into dealerships for repair, which would be relatively steep. However, mass production of such cars and parts in humungous volumes handled by multiple auto shops can create the scenario for reasonable expenses.
In similar lines, manufacturers are vying to develop future-proof auto lifts, wherein the lift should be capable of accommodating unique undercarriages of the debutants hybrid/EV vehicles.


Prime World is a multiplayer action battle arena (MOBA) developed by from the creators of Heroes of Might & Magic V, Blitzkrieg, Silent Storm and Etherlords. Prime World merges persistent RPG hero development, PvP and story-driven battles and castle building. You can hire, equip and train your heroes between battles using collectible and upgradable talents, build a thriving economy in your city, and play together with and against your friends.
Two rivals: : Play as part of the the Dokht Imperium faction or the Keepers of Adornia faction for control of "the Prime", a critical resource that alters the world and gives its users power over it.
Endless battlefield: The outcome of the war depends on each player. By controlling heroes, players support their armies, capture new territory, and attempt to destroy the enemy base. The enemy armyis also led by heroes, so victory is not easy.
Castles and Construction: Each Prime World player is the lord of his or her own castle, the main base of operations and home to the player's heroes. In the castle, players can build various buildings (from mining facilities to decorative structures), create new talents, and select sets of talents to equip their heroes with for upcoming battles.
PAX East 2015 Day 3 Recap - Echo of Soul, Gigantic, Guns of Icarus Online, Cosplay, and More!
Day 3 held the title I was most excited for personally, and you will be too, when you see more on it, and that's Gigantic.
Weekly Recap #181 Mar. 31st - Lego Minifigures, Ghost Recon Phantoms, ZMR & More!
Weekly Recap #167 Dec. 16th - Maplestory 2, Monster Madness & More!
+Visually thematic and different factions.
Description: Prime World is a multiplayer action battle arena (MOBA) developed by from the creators of Heroes of Might & Magic V, Blitzkrieg, Silent Storm and Etherlords.


text:
United States v. Johnson, 457 U.S. 537 (1982), was a United States Supreme Court case.

Background
United States Secret Service agents arrested a suspect at his home without an arrest warrant. Before trial, the defendant sought to suppress his oral and written statements as fruits of an unlawful arrest not supported by probable cause. The United States District Court found the arrest to be proper and admitted the evidence, and a jury then convicted the defendant of a federal crime.  The Ninth Circuit affirmed the judgment of conviction.

While the defendant's petition for rehearing was pending before the Court of Appeals, the United States Supreme Court decided Payton v. New York, , in which it was held that the Fourth Amendment prohibits the police from making a warrantless and nonconsensual entry into a suspect's home to make a routine felony arrest.  The Court of Appeals granted the defendant's petition for rehearing, withdrew its prior opinion, and on the strength of Payton v. New York reversed the judgment of conviction. The government petitioned for rehearing, arguing that the principles of Payton should not apply retroactively to an arrest that had occurred before Payton was decided. The Court of Appeals disagreed, denied the petition for rehearing, and amended its opinion to clarify that Payton did apply retroactively.

Opinion of the Court
On certiorari, the United States Supreme Court affirmed 5-4. In an opinion by Blackmun, J., it was held that the rule announced in Payton v. New York applies to a case which was pending on direct appeal when Payton was decided, Payton not having applied settled precedent to a new set of facts, not having announced an entirely new and unanticipated principle of law, nor having held either that the trial court lacked authority to convict the defendant nor that the Fourth Amendment immunized his conduct from punishment.

Brennan, concurring, expressed the view that the court's decision left undisturbed the Court's retroactivity precedents as applied to convictions final at the time of decision.

White wrote the dissent, expressing the view that retroactive application of a new constitutional doctrine is appropriate when that doctrine's major purpose is to overcome an aspect of the criminal trial that substantially impairs its truth-finding function and so raises serious questions about the accuracy of guilty verdicts in past trials and that new extensions of the exclusionary rule do not serve this purpose and will not generally be applied retroactively, and that there was nothing extraordinary about the ruling in Payton to justify an exception to this general rule.

External links

United States Supreme Court cases
United States Supreme Court cases of the Burger Court
United States Fourth Amendment case law
1982 in United States case law

redpajama_set_name: RedPajamaWikipedia


text:
'Evan Almighty' International Trailer Is Online
Evan Almighty International Trailer Is Online
The Bruce Almight sequel arrives in theatres on June 22.
Movieweb Contributor
Yahoo! UK & Ireland has posted the new international trailer for Universal Pictures' Evan Almighty, which arrives in theatres on June 22nd.
The comedy stars Steve Carell, Morgan Freeman, Lauren Graham, John Goodman and Wanda Sykes.
CLICK HERE to check out the trailer!
Steve Carell (The 40 Year Old Virgin), reprising his role as the polished, preening newscaster Evan Baxter of Bruce Almighty, is the next one anointed by God to accomplish a holy mission in the hilarious new comedy Evan Almighty. Blockbuster comedy director Tom Shadyac (The Nutty Professor, Liar Liar, Bruce Almighty) returns behind the camera for this next episode of divine intervention. This time, however, his cast grows two-by-two.
Newly elected to Congress, Evan leaves Buffalo behind and shepherds his family to suburban northern Virginia. Once there, his life gets turned upside-down when God (Morgan Freeman) appears and mysteriously commands him to build an ark. But his befuddled family just can't decide whether Evan is having an extraordinary mid-life crisis or is truly onto something of Biblical proportions...
Promising Young Woman Director Defends Controversial Ending as Realistic and Inevitable


text:
Historical Order
Antibody-drug Conjugate/ADC Related
Cell Cycle/DNA Damage
MAPK/ERK Pathway
Metabolic Enzyme/Protease
Protein Tyrosine Kinase/RTK
Stem Cell/Wnt
Vitamin D Related
Arenavirus
Filovirus
Virus Protease
PROTAC-linker Conjugate for PAC
DAPK
MDM-2/p53
Thymidylate Synthase
TNF Receptor
Antifolate
Checkpoint Kinase (Chk)
Deubiquitinase
DNA Alkylator/Crosslinker
Eukaryotic Initiation Factor (eIF)
Haspin Kinase
LIM Kinase (LIMK)
Microtubule/Tubulin
Arp2/3 Complex
Gap Junction Protein
Protein Arginine Deiminase
Adenylate Cyclase
Adiponectin Receptor
Bombesin Receptor
Bradykinin Receptor
Cholecystokinin Receptor
CRFR
EBI2/GPR183
Arginase
Aryl Hydrocarbon Receptor
Cyclic GMP-AMP Synthase
IFNAR
Interleukin Related
NO Synthase
NOD-like Receptor (NLR)
PGE synthase
MAPKAPK2 (MK2)
Ribosomal S6 Kinase (RSK)
CRAC Channel
EAAT2
HCN Channel
iGluR
Monoamine Transporter
Monocarboxylate Transporter
Na+/Ca2+ Exchanger
Na+/HCO3- Cotransporter
Na+/K+ ATPase
NKCC
15-PGDH
5 alpha Reductase
Aldehyde Dehydrogenase (ALDH)
Aminoacyl-tRNA Synthetase
Aminopeptidase
Angiotensin-converting Enzyme (ACE)
ATGL
ATP Citrate Lyase
Cathepsin
Dihydroorotate Dehydrogenase
Amyloid-β
Beta-secretase
Dopamine Transporter
Keap1-Nrf2
MALT1
PDK-1
E3 Ligase Ligand-Linker Conjugate
Ligand for E3 Ligase
Ligand for Target Protein for PROTAC
Target Protein Ligand-Linker Conjugate
Ack1
BMX Kinase
c-Fms
c-Met/HGFR
Discoidin Domain Receptor
Insulin Receptor
Hippo (MST)
Oct3/4
sFRP-1
β-catenin
γ-secretase
TGF-β Receptor
VD/VDR
Estrogen Receptor/ERR
Progesterone Receptor
Thyroid Hormone Receptor
Disease Related Products
Inflammation/Immunology
Compound Screening Libraries
Bioactive Compound Library
GPCR/G protein Compound Library
Clinical Compound Library
Inhibitor Kits
Inhibitory Antibodies
Cell Counting Kit-8
GHSR (Growth hormone secretagogue receptor) is a member of the G-protein coupled receptor family. GHSR may play a role in energy homeostasis and regulation of body weight. The pathway activated by binding of ghrelin to the growth hormone secretagogue receptor, GHSR1a, regulates the activation of the downstream mitogen-activated protein kinase, Akt, nitric oxide synthase, and AMPK cascades in different cellular systems. One of the important features of GHSR1a displays constitutive activity possessing basal activity in the absence of an agonist, resulting in a high degree of receptor internalization as well as of signaling activity. Inverse agonists for the ghrelin receptor could be particularly interesting for the treatment of obesity. A range of selective ligands for the GHSR receptor are now available and are being developed for several clinical applications. GHSR agonists have appetite-stimulating and growth hormone-releasing effects, and are likely to be useful for the treatment of muscle wasting and frailty associated with old-age and degenerative diseases. On the other hand, GHSR antagonists have anorectic effects and are likely to be useful for the treatment of obesity.
GHSR Related Products (17):
By Effects:
Inhibitors (2) Agonists (9) Antagonists (1)
HY-50844
Ibutamoren Mesylate (MK-677) is a potent, non-peptide Growth hormone secretagogue receptor (GHSR) agonist. Ibutamoren Mesylate is an orally active growth hormone (GH) secretagogue.
Anamorelin (RC-1291) is a potent ghrelin receptor agonist with EC50 value of 0.74 nM in the FLIPR assay.
HY-14734A
Anamorelin hydrochloride
Anamorelin (RC-1291) hydrochloride is a potent ghrelin receptor agonist with EC50 value of 0.74 nM in the FLIPR assay.
HY-103007
TC-G-1008
TC-G-1008 (GPR39-C3) is a potent and orally available GPR39 agonist with EC50 values of 0.4 and 0.8 nM for rat and human receptors respectively.
HY-U00433A
JMV 2959 hydrochloride
JMV 2959 hydrochloride is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32±3 nM in LLC-PK1 cells.
HY-P0089A
Human growth hormone-releasing factor TFA
Human growth hormone-releasing factor TFA (Growth Hormone Releasing Factor human TFA) is a hypothalamic polypeptide and stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary[1].
L-692585
L-692585 is a potent and nonpeptidyl growth hormone secretagogue receptor (GHS-R1a) agonist, with a Ki of 0.8 nM. L-692585 acts directly on somatotropes causing GH release[1][2].
TM-N1324
TM-N1324 is an agonist of G-Protein-Coupled Receptor 39 (GPR39) with EC50s of 9 nM/5 nM in the presence of Zn2+, and 280 nM/180 nM in the absence of Zn2+ for human/murine GPR39.
Capromorelin Tartrate
Capromorelin Tartrate is an orally active, potent growth hormone secretagogue receptor (GHSR) agonist, with Ki of 7 nM for hGHS-R1a.
PF-5190457 (PF-05190457) is a potent and selective ghrelin receptor inverse agonist with a pKi of 8.36[1].
HY-P0089
Human growth hormone-releasing factor
Human growth hormone-releasing factor (Growth Hormone Releasing Factor human) is a hypothalamic polypeptide and stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary[1].
AZP-531
AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.
L-692429 (MK-0751) is a benzolactam derivative and a nonpeptidyl growth hormone secretagogue (GHS) agonist. L-692429 binds to G protein-coupled receptor with a Ki of 63 nM[1][2].
Alexamorelin Met 1
Alexamorelin Met 1 is one of the metabolites of alexamorelin. The heptapeptide Ala-His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2 (Alexamorelin) is a synthetic molecule which inhibits growth hormone secretagogue binding in vitro.
Ulimorelin
Ulimorelin (TZP-101) is a ghrelin receptor (GRLN) agonist with an EC50 of 29 nM and a Ki of 16 nM. Ulimorelin is a prokinetic agent and causes vasorelaxation through competitive antagonist action at α1-adrenoceptors. Ulimorelin stimulates intestinal motility and is used for malnutrition[1][2][3].
Obestatin(rat)
Obestatin(rat), encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin(rat) has anti-inflammatory, anti-myocardial infarction and antioxidant activities[1][2].
Obestatin(rat) TFA
Obestatin(rat) TFA, encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) TFA suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin(rat) TFA has anti-inflammatory, anti-myocardial infarction and antioxidant activities[1][2].
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text:
Q: Swift - JSQMessagesViewController Showing incoming avatar email or username I'm developing a chat app,And  I have this
The problem now is how can i show the username on top of the message bubbles like this on the demo? https://raw.githubusercontent.com/jessesquires/JSQMessagesViewController/develop/Screenshots/screenshot2.png
I'm looking for override func collectionView(collectionView: JSQMessagesCollectionView!, senderDisplayNameDataForItemAtIndexPath indexPath: NSIndexPath!) -> JSQMessageAvatarImageDataSource! But I think it's not possible. What do you think the solution here? Thanks!

A: For viewing userName top of the incoming message JSQ is having below methods.
//MARK: To View  usernames above bubbles

override func collectionView(collectionView: JSQMessagesCollectionView!, attributedTextForMessageBubbleTopLabelAtIndexPath indexPath: NSIndexPath!) -> NSAttributedString! {
    let message = messages[indexPath.item];

    // Sent by me, skip
    if message.sender() == sender {
        return nil;
    }

    // Same as previous sender, skip
    if indexPath.item > 0 {
        let previousMessage = messages[indexPath.item - 1];
        if previousMessage.sender() == message.sender() {
            return nil;
        }
    }

    return NSAttributedString(string:message.sender())
}

override func collectionView(collectionView: JSQMessagesCollectionView!, layout collectionViewLayout: JSQMessagesCollectionViewFlowLayout!, heightForMessageBubbleTopLabelAtIndexPath indexPath: NSIndexPath!) -> CGFloat {
    let message = messages[indexPath.item]

    // Sent by me, skip
    if message.sender() == sender {
        return CGFloat(0.0);
    }

    // Same as previous sender, skip
    if indexPath.item > 0 {
        let previousMessage = messages[indexPath.item - 1];
        if previousMessage.sender() == message.sender() {
            return CGFloat(0.0);
        }
    }

    return kJSQMessagesCollectionViewCellLabelHeightDefault
}

The above code is worked for me, I hope it will work for you also. For more info you can see Demo
https://github.com/jessesquires/JSQMessagesViewController

A: I think you are just missing.
override func collectionView(collectionView: JSQMessagesCollectionView?, layout collectionViewLayout: JSQMessagesCollectionViewFlowLayout?, heightForMessageBubbleTopLabelAtIndexPath indexPath: NSIndexPath!) -> CGFloat {
    // Override point:
    //
    // Here we check for what our setting is for displaying the senderDisplayName
    // if we dont want to display it we just return a height of 0.
    // Then we check to see if (The current user)
    // sent the message if so we return 0, because we know our own name,
    // other wise we return the defualt height.
    //

    return kJSQMessagesCollectionViewCellLabelHeightDefault
}

That is what throws most people Let me know if that helps


As speakers at conferences, commentators quoted in articles, and respondents to surveys, law department lawyers convey their preferences. Those expressed preferences, however, may not translate into practice. Hypocrisy is too strong a term, but often there is a failure to walk the talk, a gap between espoused values and acted values.
Economists favor the term "revealed preference" (that is, preference revealed by behavior) as a more reliable expression of a belief (See my post of Feb. 7, 2006 on perceived behavior.) than expressed preferences, and they look for ways to spot what people actually do, as compared to what they say they do. For example, surveys would have us believe that in-house dissatisfaction with law firms is rampant. Revealed preferences, however, exist, such as data on consistent use over time of the same primary law firms, and belie those survey responses.


text:
Haunt to amerykański film fabularny z 2013 roku, napisany przez Andrew Barrera oraz wyreżyserowany przez Maca Cartera. Jest to horror oraz debiutancki film pełnometrażowy Cartera. Jego fabuła skupia się na losach osiemnastolatka, który wprowadza się do nawiedzonego domu. Premiera obrazu odbyła się 6 listopada 2013 podczas uroczystej gali w Film Society of Lincoln Center w Nowym Jorku. 7 lutego 2014 Haunt został udostępniony klientom serwisów VOD w Stanach Zjednoczonych. Odbiór horroru przez krytyków był pozytywny.

Obsada
 Harrison Gilbertson − Evan Asher
 Liana Liberato − Samantha "Sam" Richards
 Jacki Weaver − Janet Morello
 Ione Skye − Emily Asher
 Brian Wimmer − Alan Asher
 Danielle Chuchran − Sara Asher
 Ella Harris − Anita Asher
 Jan Broberg − Meredith Tanner
 Kasia Kowalczyk − demon

Linki zewnętrzne

Przypisy

Amerykańskie filmy z 2013 roku
Amerykańskie filmy z gatunku horror
Filmy fantastyczne z 2013 roku


We love Freddy's Frozen Custard and Steak Burgers! And we love that they are having a special fundraiser for Joy in the Cause on June 13th from 5:00 to 9:00!
Bring in this flyer and 15% of sales will be donated to Joy In The Cause. You can also just show the flyer on your phone and it will count as well.
This is the first of many supportive endeavors with Freddy's. Stay tuned for more details!


Based in Ballymacarrett Road, Belfast, The Beat Initiative is an art shop.
The Beat Initiative is in Ballymacarrett Road, Belfast. You can view a list of neighbouring businesses by going to the Ballymacarrett Road page.
If you would like a list of other arts sports, leisure, entertainment listings throughout Belfast, please visit the Arts and Culture section of this website.
Note: the pin is positioned at the postcode centre, and may not correspond with the precise location of 9-11 Ballymacarrett Road.


Project ZATO is a visualization of the memories of residents of closed cities and my own experience of visiting these places, inspired by discussions on web forums, announcements by municipal authorities, and publications on social media sites. The photographs are staged, and the project does not contain any photos that I took myself in the closed cities. The only exceptions are several images of municipal infrastructure that I commissioned from local photographers for the print edition of the project, in order to show how these cities look from the inside.
ZATO - Sergey Novikov from The Anamorphosis Prize on Vimeo.


Snow is a at-home teeth-whitening technology that doesn't require a prescription and can be FDA accepted . According to Snow,"top star dentists" use it and are pleased with the results. They say it is an award-winning system for whitening teeth.
The Harvard science research firm, Snow Labs, located in Scottsdale, Arizona, serves over 100,000 customers. They say they are constantly trying to improve the technology and consistently hoping to discharge products. Additionally they donate a few of the proceeds to help provide treatments to children who can't manage them.
The Snow teeth whitening treatment is a FDA-approved, at-home tech that gives folks dentist-level whitening at a fraction of the cost. It was created by a Harvard science study firm.
They do have a results guarantee that is 100% Even though they do not have a warranty. This means if you are not happy with your results the whitening ointment will be replaced by them. Simply put, they don't accept returns or issue any money refunds — they will just issue store credit in the kind of a card.
Clients and reviewers call Snow revolutionary and groundbreaking. It appears to work better than whitening strips and strips — many even compare it to whitening procedures.
The majority of the individuals who've employed Snow see results in about three days, but every individual should use it until they see the results they want. It could take up to 21 days of routine use for 15-30 minutes each session.
The majority of the user reviews must do with customer support from early on in the company's life. The product seems to work and hopefully the client support has improved over the years.
For the most part, testimonials of Snow are extremely favorable. Obviously, not every client will experience exactly the very same results but it is generally considered a technology.
You apply a whitening serum. Basically, it's a substance that you paint onto your teeth. Next, you place the Snow apparatus into your mouth for 10 minutes each day — it fits over your teeth like a mouth guard that is bulky.
The Remineralization Gel you should use following the whitening treatment, especially in the event that you have sensitive teeth. This gel returns vitamins and minerals to your teeth, cut down sensitivity, and can help strengthen your tooth enamel. You shouldn't do it every day but instead take a break for 1-3 days Should you have teeth and gums.
Snow is FDA approved, and it is a large plus. So it is relatively safe. During the treatment, you do end up swallowing a little but not enough that it is painful. In fact, even when you're breastfeeding, you can still use this whitening treatment.


Authors: Satoshi Tsutsui and David Crandall.
A key problem in automatic analysis and understanding of scientific papers is to extract semantic information from non-textual paper components like figures, diagrams, tables, etc. This research always requires a very first preprocessing step: decomposing compound multi-part figures into individual subfigures. Previous work in compound figure separation has been based on manually designed features and separation rules, which often fail for less common figure types and layouts. Moreover, no implementation for compound figure decomposition is publicly available.
This paper proposes a data driven approach to separate compound figures using modern deep Convolutional Neural Networks (CNNs) to train the separator in an end-to-end manner. CNNs eliminate the need for manually designing features and separation rules, but require large amount of annotated training data. We overcome this challenge using transfer learning as well as automatically synthesizing training exemplars. We evaluate our technique on the ImageCLEF Medical dataset, achieving 85.9% accuracy and outperforming manually engineered previous techniques. We made the resulting approach available as an easy-to-use Python library, aiming to promote further research in scientific figure mining.
— easy to use figure separator!


text:
In bioinformatics, the EzTaxon database is a web-based tool for the identification of prokaryotes based on 16S ribosomal RNA gene sequences. EzTaxon is an open access database that is produced and maintained by ChunLab, Inc.

The EzTaxon database contains sequences of type strains of prokaryotic species with validly published names. Although EzTaxon is mainly used for the routine identification of prokaryotic isolates, sequences from uncultured taxa were not included. Thus in 2012, EzTaxon was extended to include uncultured prokaryotes and the name of the database was changed to EzTaxon-e.

Naming convention
Taxa names included in EzTaxon-e represent groups of uncultured sequences found in public domain databases. The names included in EzTaxon-e have no standing in formal nomenclature but they were created to help in the comparison of microbial communities and diversity in nature.

 New names found in EzTaxon-e are formed by adding special suffixes to Genbank sequence accession numbers of sequences (e.g. AB177171_s -> species of which the sequence entry AB177171 serves type; AB177171_g -> genus; AB177171_f -> family; AB177171_o -> order; AB177171_c -> class; AB177171_p -> phylum).
 Well-known names have been preserved for historical reasons. SAR11, the famous marine inhabitant, is labeled as SAR11(order), and further divided into 4 families (SAR11-1_f to SAR11-4_f).
 Based on 16S rRNA sequence phylogeny, some obviously misclassified species have been renamed using special suffixes. For example, Bacteroides pectinophilus is not an authentic member of the genus Bacteroides. However, it may represent a novel genus in the family Lachnospiraceae. Therefore, in the EzTaxon-e database, Bacteroides pectinophilus is placed under a tentatively named new genus Bacteroides_g1.
Sequences and tentative taxa that start with "4P" are products of the Roche 454 GS FLX Titanium system.

References

Biological databases
Microbiology
Prokaryotes