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City of Prescott Response to COVID-19
Earlier today the Mayor of the City of Prescott signed Proclamation of Emergency, resolution number 2716, which is attached to this document. He later hosted a press conference to update the public about the community response to COVID-19 and the various guidelines that have been handed down from Federal and State agencies in recent days. The Mayor's guests were Leslie Horton, Director of Yavapai County Community Health Services, John Amos, CEO of Yavapai Regional Medical Center, along with his Chief Medical Officer Anthony Torres and Chief Nursing Office Diane Drexler, and Sheri Heiney, President of the Prescott Chamber of Commerce.
Below is a comprehensive list of city services and how they will change. All changes will be in place until further notice, unless otherwise noted.
City Boards and Commissions
Council meetings will not have an in-person audience. Meetings will be live streamed through various channels. Council members will be present to conduct the meeting. Meetings will be aired on Channel 64, and Facebook Live. Questions will be allowed to be submitted online, in advance of the meeting. An email link will be developed and made available. A concerted effort will be made to delay consideration of issues with widespread community interest
All non-essential boards and commission meetings will be suspended.
A separate detailed press release was sent out earlier today on this.
The Police lobby is closed; phone and online reporting is offered as an alternative for reporting crimes. A separate press release was sent out earlier today about this.
The Citizen on Patrol volunteer program will be suspended until further notice.
All fire stations are closed to the public.
Increased sanitization of trucks and surfaces inside stations has commenced and will continue.
The Prescott Fire Department is working with YRMC and the County to create on-call medic for phone triage to determine appropriate patient transfer protocols.
Prescott Public Library will be closed to public access Tuesday, March 17. Basic curbside service will begin 10 a.m. Friday, March 20. Curbside Services will be available Tuesday through Saturday 10 a.m. to 6 p.m.
All library programming and uses of community meeting rooms are suspended until April 13.
Services to be reevaluated by April 13
Ask a Librarian telephone reference is available currently. Services will be available Tuesday-Saturday 10 a.m.-6 p.m.
Late fees accrued until situation improves and regular library service resumes will be waived.
Due dates will be extended.
A separate press release was sent on March 16 about this.
Recreation Services/Facilities
Beginning Tuesday, March 17 through Sunday, May 10, 2020, or as determined:
CANCELLED– All Special Events scheduled within the Prescott limits
CANCELLED– All Park reservations.
CANCELLED– All organized team sports, leagues, tournaments and user groups, to include City Adult Volleyball leagues
CLOSED– Rowle P. Simmons Adult Center
CLOSED– Centennial Center
CLOSED– All Park Ramadas
The following locations will remain open, however, the general public is encouraged to practice good hygiene, hand washing and practice social distancing. General public is discouraged from gatherings of 10 or more people.
OPEN– All athletic fields will remain open at this time (with the exception of Willow Creek field, Lower Bill Vallely field, and Kuebler field), but not for structured practices or gatherings. Reservations will not be taken during this timeframe.
OPEN– Pickleball Courts will remain open, however, every other court will be locked
OPEN- Parks, lakes and playgrounds will remain open.
OPEN– Antelope Hills Golf Course will remain open.
All parking fees at City of Prescott recreational facilities, parks and trails are waived during this timeframe
The City is encouraging online and phone bill payment. PSAs are circulating on all radio stations to encourage citizens to find alternative ways to monitor and pay their bills.
Reviewing your water usage
Email utility.billing@prescott-az.gov to put in service cancellations and to ask billing questions.
Starting service at a new address
Signing up for automatic payment of your utility bill
Or just paying your current bill
If you have questions, or do not have access to the internet, we would be glad to assist you over the phone at 928-777-1291
Trash collection will continue as normal
Transfer station will remain open. Please be respectful of the City's attendant by using best hygiene practices.
The Streets Department will provide signs for restaurants "Reserved, Curbside Pickup 15 Min. Parking". The Communications Department will send a notification and Public Works will take sign orders and will place two per restaurants upon request.
The City is still accepting paper plans at the counter at this time. Again, please be respectful of the City's permit technicians by using best hygiene practices. Community Development will display notices that an electronic version of ALL plan submittals will be required as of Monday, March 30 There will be an option for electronic submissions soon.
Inspections will continue without interruption.
Incidental status inquiries (building permits, plan review, zoning questions) are requested via front counter signage and other messaging to be performed by phone or email (i.e. NOT in person if at all possible).
Commercial flights are continuing through United Expess, operated by SkyWest Airlines.
The Airport is taking extra cleaning precautions and deep cleaning areas between flights.
The Airport is following FAA guidelines for passenger safety.
New terminal construction continues
The City is cancelling training, or providing remote options.
In-Person Recruitment/Selection suspended. Online or phone interviews only.
No walk in job applications. Online only.
Each department is working through/on plans to have non-essential personnel work from home.
Employee Leave:
Employees that are ill (not COVID-19) must stay home and use existing leave banks.
Emergency leave bank provided for employees and/or family members who contract COVID-19 (no use of personal banks). If at home family members have virus – employee must self-quarantine. City Manager goal is to make employees whole whenever they are affected by virus.
The video of today's press conference can be found on the City's Facebook Page, and at Prescott-az.gov on the COVID-19 resource page. You can also stream on demand at PrescottMediaCenter.org.
COVID-19 Emergency Proclamation
John Heiney
Community Outreach Manager
201 S Cortez St
If I have a question for the City, who should I contact?
If you are a member of the media, please contact Communications.
If you would like to contact the Mayor or a Councilmember, contact information can be found here
If you would like to contact a specific department, contact information can be found here
City Seeks Applications for Council Vacancy
In an earlier release, Councilwoman Billie Orr announced her resignation from Prescott City Council effective January 19, 2021. At their Voting Meeting on January 12 Prescott City Council voted to accept applications to fill the vacancy through the November 2023… Read more »
Martin Luther King, Jr. Day Schedule
Councilwoman Billie Orr Announces Her Resignation from the City Council
View the Latest
News Events Notices

redpajama_set_name: RedPajamaCommonCrawl


Let our excellent condition trailer be part of your outdoor travels this summer! If you are looking for a unit with TV, wifi , satellite TV or Bluetooth then this trailer is not for you. However, if you want to go back to basics and enjoy your company and spend quality time with them, then this is the unit for you!
Enjoy quiet time around the camp fire roasting marshmallows or cooking up some s'mores . Share and listen to camping stories or just enjoy looking at the stars on a clear summer night. Camping chairs will be included to enjoy both!
Extend the motorized awning when it's raining. RV toilet paper, dishes, utensils, cooking pots and pans are all included, just bring your own bedding, pillows, blankets and beach towels and of course your food and other camping necessities.
*No smoking of cigarettes, cannabis and vaping allowed and no pets please due to allergy to one of our family members.
** Our trailer requires a mandatory and working 7 pin connector to attach the trailer to your towing vehicle to operate all the safety features while being towed. Please ensure that your vehicle do have one. No 7 Pin connector no tow. A remote controlled electric tow brake control is available as an add on if your vehicle is not equipped with one.
* Please check your vehicles towing capacity.
**Roadside assistance and insurance from Wheelestate is required to rent our trailer! Please make sure it is included at checkout.
**Mandatory out of Canada Fee is required for wear and tear involving long distance driving. Please contact us if you are planning to rent our trailer out of Canada. An authorization will be required to cross the borders.
50 Remote controlled Electric Tow Brake Control.. Pls consult your towing vehicle if it has a factory or an aftermarket tow brake is installed. Please note that an electric tow brake is mandatory in Canada when towing a trailer. Pls contact us if you have anymore questions?
30 This is Mandatory fee if you are taking the trailer out of Canada for wear and tear associated with long distance driving . Please contact the owners . An authorization will be required to cross the US/Canada borders.
Unfortunately not. One of our family members is allergic to animal dander. Please respect this and future renters.
Does the fridge work on propane?
Unfortunately not. You will need at least a 15 Amp serviced campsite to run the A/C solely. Sites that have 30 Amp power will run all of the appliances of the trailer.
What can I ran on batteries?
Can I put fresh water into the tank before I travel?
Yes you can but please be mindful of the capacity of the trailer to tow it safely.Also be mindful that loading the trailer with water will increase your gas mileage on your vehicle. Having a full tank will also affect your stopping time.safety first!
What SUV will pull the trailer?
Please consult your vehicle manual. We will not be responsible for damage to your vehicle due to improper towing and the trailer being too heavy for your vehicles towing capacity.
We will ensure that our trailer will be clean as well the items that's included. We expect that the trailer will be returned cleaned or $150 cleaning fee will be taken out off your security deposit to cover the time to clean the trailer.
Is smoking cigarettes , cannabis or vaping allowed?
Smoking of cigars, cigar, cannabis and vaping is NOT allowed inside the trailer. One of our family members has respiratory issues. Please be respectful to us and future guests. We will take off $500 off your security deposit to deodorize the trailer professionally.
Do I need an electric tow brakes ?
Is the towing hitch and sway bars included in the rental?
Yes, the hitch receiver will fit into a 2 inch receiver attach to your vehicle. Our trailer is equipped with a superior quality sway bars and a towing hitch to tow the trailer safely. Safety pin is also included :) Safety first!
Can I take the trailer out of Canada?
Yes you can. A mandatory fee is required to take the vehicle out of Canada to cover the wear and tear of long distance driving of the trailer. We just ask the renters to contact us if planning to take out out of the country. An authorization is required for the trailer to cross the borders legally.
Do I need to buy insurance and roadside assistance from WheelEstate?
Yes we require both to rent our trailer. Our trailer is in excellent condition however with many moving parts, it may not be the case all the time. Insurance is for your piece of mind and ours :) Roadside assistance is available through Wheelestate if you don't have a membership with AMA . Please note that towing a trailer costs up to $1000 and it will be the renters responsibility.
Do I need a special towing mirrors?
Safety is everything when towing a trailer. It is necessary that you can see both sides of trailer at all times when you are towing it. They are available at Canadian Tire.
Is there a checklist available?
A before and after towing checklist will be provided to ensure safe towing.
Do I need to empty all the tanks before we return the trailer?
Yes you do. We will expect that the fresh water tank will be empty. We also expect the gray and black tanks emptied and cleaned prior to returning. Cost to dump and clean the tanks will be taken out of your security deposit . You can empty out the tanks in most campsites . It's also safer to tow a light than a heavy trailer. Again, think safer first!
Why Do I need a 7 pin trailer harness?
Our trailer requires a 7 pin wiring harness to operate all of the safety features of the trailer when being towed. Please also ensure that your 7 pin wiring harness is working. We will NOT let you take out our trailer without a working and property operational wiring harness. We would hate for you to lose your money over a defective equipment. SAFETY FIRST!
Is the pick up and drop off time flexible?
No. We have set the pick up and drop off time to be specific because we want you to know the trailer well before you head out. We also need ample amount of daylight to do the post trip walk through to ensure everything is in the same condition prior to your trip. Our storage facility also has a closing time .We will charge $50/hour from your security deposit if the drop off time is late. If you are unsure that you can drop off the trailer prior to the drop off time, we highly encourage to book another night and bring the trailer the next day for post trip inspection.
The fridge, stove and the furnace runs on propane.


What makes oldest daughters in families HAVE an intense animosity towards their mothers?
In my experience apples fall directly off the apple tree they grew on.
I think sometimes a clash of personality is a big cause of this. If two people are alike then friction occurs. Plus I have seen mothers, try to get the oldest daughter to do what they say. Some mothers think they know everything. I think mothers want the eldest daughter to set an example for the other girls. Follow the leader, you might say.
Do you know someone who is prejudice of larger families?
Do you know someone who is prejudice of larger families?Why do some people have an ignorant belief that moms of large families cannot be the same as moms with one or 2?
How do you feel about psychological concept that at certain age of the daughters mothers begin to compete with them? Is there a real envy in a mother about her daughter, because she is young and is having her entire life before her, while the life of the mother is at its middle point?
Why most mothers prefer sons than daughters?
Why most mothers prefer sons than daughters?Mothers are more appreciated when their first born is a boy and prefer boys to girls, the favorite child is often the boy, can this affect children when older?
What do you think of woman with more than 8 children?


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Albert Aftalion, född 21 oktober 1874, död 6 december 1956, var en fransk nationalekonom.

Aftalion var professor i statistik vid Paris universitet. I sitt mest kända arbete, Les crises périodiques de surproduction (2 band, 1913), utvecklade han en konjunkturteori baserad på den så kallade "accelerationsprincipen". Enligt denna teori kan måttliga växlingar i produktionen leda till kraftiga växlingar i realkapitalproduktionen, som vid kriserna möjliggör en allmän överproduktion av konsumtionsvaror, vilket leder till ett allmänt fall i varornas gränsnytta. Bland hans övriga arbeten märks Les fondements du socialisme (1923) och Monniae, prix et change (1927).

Källor
 Svensk uppslagsbok, andra upplagan 1947

Franska nationalekonomer
Personer i Frankrike under 1900-talet
Födda 1874
Avlidna 1956
Män
Svensk uppslagsbok

redpajama_set_name: RedPajamaWikipedia


text:
Q: z-index stacking elements outside of what is specified I used z-index to stack a few input boxes and some text on top of an image which worked how I wanted it to. As I continued on and started the next section of my page it, it moved the next section up behind the image that is using z-index. How do I get my next section to follow the normal flow of the page under the image and not stacked behind it?

A: The image needs to have position: relative (not absolute) - that way it will remain part of the document flow.

redpajama_set_name: RedPajamaStackExchange


Chair Sash Buckles, Chair Band Buckles Wholesale Free Shipping over $150 - US 48 Contiguous States!
Looking for something a little extra to bling up your table chair design? Our gorgeous, high quality rhinestone chair sash buckles, chair band buckles or brooch pin are just the thing to make your table, chairs beautiful. Our Chair sashes, chair bands rhinestone buckles are available in the round rhinestone buckles, rectangular rhinestone buckles, diamond shape rhinestone buckles, heart rhinestone buckles, and crown rhinestone buckles. Beautiful rhinestone buckles are perfect for wedding, special parties.


Aromas Powai has received a lot of complaints about their service in particular. Here's the thread of conversations that I copied and pasted from a Facebook thread. click here for the original link. Sukanti Ghosh first complained, and then a lot of people collaborated with him.
Powai Info RTsukantighosh Some people just refuse to learn! Had a wonderfully lousy brunch at Aromas in Powai !
I had the worst experince there with the food. Would not recomend it even if they were giving it away for free.
the waiters walk around like they're asleep and always stuff up the order even if you order only 1 thing!! aggh!!
I found bones in my wrap! and then the repleacement also came with a whole chicken wing! It was disgusting!
Had you ever had a pancake with garlic in it? Or had the 'good fortune' of witnessing three orders coming to your table 20 minutes apart? That's what happened today! Despite numerous reminders and requests!
The quality of service is deplorable!
Had my daughter's bday party here today…most A/C's were not working…and apparently they were not since the last 2 days (and they did nothing about it)…party was a complete disaster. Feel completely cheated.
thanks friends for letting us know how bad aromas is….will never go there again…..


Pamela Anne (Kramer) Schmeling, 48, Kewaunee entered into eternal rest on Sunday evening, September 30, 2018, surrounded by her family at home. Pamela was born on January 8, 1970 in Sheboygan to Roman and Joanne Kramer. Pamela was a graduate of Sheboygan South High School and Lakeshore Technical College. She was currently employed by Shopko Optical in Sheboygan as an Optical Manager for several years until the time of her illness. On September 2, 2017, she married Keith Schmeling at Bethlehem Lutheran Church in Sheboygan. They just celebrated their First Wedding Anniversary earlier this month.
Pamela is survived by her husband: Keith, son: Brayden Reimer and step-son: Ryker Schmeling, parents: Roman and Joanne Kramer, brother: Greg Kramer, nephews: Brandon and Mason Kramer, mother-in-law: Janice Schmeling, sisters-in-law: Tammy and Kevin Swagel (Kayla, Carson and Karla) and Kim Schmeling. Also surviving is Brayden's father: James Reimer. She is also survived by aunts, uncles, cousins, and friends. She was preceded in death by her grandparents Ewald and Violet Kroening, Joe and Viola Lorier and her father-in-law Mark Schmeling.
Visitation for family and friends will be at Buchanan Funeral Home, Kewaunee, from 4-8 PM on Thursday, October 4, 2018 and at Immanuel Lutheran Church from 9:30-10:45 AM on Friday, October 5, 2018. Funeral services will be held at 11 AM on Friday, October 5, 2018 at Immanuel Lutheran Church, Kewaunee with Pastor Michael Sullivan officiating with burial to follow at Lutheran Cemetery, Sheboygan.
Pamela's family would like to extend a very special thank-you to Crystal (Will) Bailey, Sandy Pfister, Aurora at Home Hospice and Jesse, RN Aurora BayCare Medical Center for all the care and compassion extended to her during her illness. Your kindness will always be remembered.
In lieu of flowers, a memorial fund will be established for Pam's son Brayden. Memorial may be made to https://www.gofundme.com/65tu8b4.
Go to www.buchananfh.com to send condolences or sign the online guest book.


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Greek, Turkish warships in 'mini collision' amid tensions in eastern Mediterranean
A file photo shows the Turkish Navy frigate TCG Kemal Reis (F-247) is pictured in the Bosphorus strait in Istanbul, Turkey. (Reuters)
Published: 14 August ,2020: 06:48 PM GST Updated: 14 August ,2020: 07:01 PM GST
A Greek and a Turkish warship were involved in a mild collision on Wednesday during a standoff in the eastern Mediterranean, in what a Greek defense source called an accident, but Ankara described as a provocation.
Tensions between the NATO allies have risen this week after Turkey sent a survey vessel to the region, escorted by warships, to map out sea territory for possible oil and gas drilling in an area where Turkey and Greece both claim jurisdiction.
The Turkish Oruc Reis survey ship has been moving between Cyprus and the Greek island of Crete, shadowed by a number of Greek frigates. On Wednesday one of them, the Limnos, was approaching the survey vessel when it came into the path of one of its Turkish naval escorts, the Kemal Reis.
For all the latest headlines follow our Google News channel online or via the app.
The Greek frigate maneuvered to avoid a head-on collision and in the process its bow touched the rear of the Turkish frigate, the defense source said, calling it a "mini collision."
"It was an accident," the source said, adding the Limnos was not damaged. It subsequently took part in a joint military exercise with France off Crete on Thursday morning, the person said.
In Switzerland on Friday, Turkish Foreign Minister Mevlut Cavusoglu said Athens needs to act with reason and called on the European Union to stop "pampering" Greece ahead of an EU foreign ministers meeting to discuss the issue later on Friday.
Greece "should not attempt to provoke Oruc Reis like it did two days ago or it will receive a response," he said, adding the European Union should not give it "unconditional support."
A file photo of the Turkish seismic exploration ship 'Oruc Reis' sailing at sea. (Reuters)
Turkish President Tayyip Erdogan said the naval Kemal Reis had fended off an attack by Greek vessels and also warned of retaliation.
Greece says Turkey's ship in eastern Mediterranean 'threatening' peace
Macron seeks EU sanctions over Turkish 'violations' in Greek, Cypriot waters
Relations between Greece and Turkey have long been fraught with tension. Disputes have ranged from boundaries of offshore continental shelves and airspace to the ethnically split island of Cyprus. In 1996 they almost went to war over ownership of uninhabited islets in the Aegean Sea.
In a call with Erdogan on Thursday, European Council President Charles Michel recalled the EU's full solidarity with Greece, an EU official said. Michel called for de-escalation of tensions, said provocations should be avoided and added that dialogue is preferred, the official added.
Cavusoglu said Switzerland had offered to mediate the dispute between Turkey and Greece and that Ankara had agreed to this in principle.
EU should reassess relations with Turkey: Austrian FM
The European Union should reassess its relations with Turkey in light of a series of recent events, Austrian Foreign Minister Alexander Schallenberg ... Middle East
France should refrain from 'escalating tensions' in eastern Mediterranean: Turkey
Turkish Foreign Minister Mevlut Cavusoglu said on Friday France should refrain from steps that escalate tensions in the eastern Mediterranean, where ... Middle East
Turkey to continue its Mediterranean drilling operations until end of August: Erdogan
Turkey will continue its drilling operations in the eastern Mediterranean until August 23, Turkish President Recep Tayyip Erdogan said on ... Middle East
Israel's Netanyahu discusses plea bargain in graft trial: Reuters


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Tempers flare in Second CoC game, SRJC comes out on top.
The Polar Bears are no strangers to the penalty box, but in Friday night's match against College of the Canyons, they kept their cool when it mattered most and captured an 8-2 victory.
After beating CoC 6-2 on Thursday, the two teams met for a rematch Friday. Right out the gate, the Polar Bears looked a bit lost; Misconnections, turnovers, and a starting line that looked uncomfortable together. But the Polar Bears still managed to end the period with a 2-1 lead, thanks to a Blake Johnson goal and Matt Kiticich's first goal as a Polar Bear.
"We were just chipping and dumping; trying to keep the pressure up. We were causing some simply turnovers, making simply passes and got it to the point and to the back of the net," Kiticich described as the setup of his first goal."
Players came out in the second period looking better than they did in the first, pulling off a goal by Brandon Bronze and Andrew Mason's first SRJC goal.
"Our play in the first period was chaotic; we didn't play our game," said Chris Whitten, who had an assist on SRJC's first goal. "[Mike] Kovanis [head coach] did a great job in-between periods, and our strategy improved tremendously."
"We played our style of play in the second period and controlled the game better," he continued. "Bronze and Mason did a great job getting our team fired up. The talking on the bench shows we're really becoming a closer family."
With a 4-2 lead going into the final period, the game was completely up for grabs. The teams traded penalties for 11 minutes before Josiah Nikkel scored a power play goal. From there, the tension on the ice continued to grow and CoC proved the team just couldn't handle the heat.
In a disputed play in the CoC's offensize zone, two players collided for what CoC believed to be an intentional hit. No penalty was called and a CoC forward and coach were ejected from the game. SRJC skated with a five-minute man advantage, allowing Jackson Waldron to score and Nikkel to add to more to complete the hat trick. Two CoC slashing penalties also contributed to the Polar Bear's end of game offensive blowout.
While the Polar Bears scored timely goals, it was Dominic Jones' impressive play in net that really silenced CoC. Jones performed near acrobatic saves, deflecting 21 of 23 shots and earning save no. 3 on the season.
SRJC outshot CoC 67- 23 in the game and will face the team one more time this season: in the Polar Bear's November showcase. After nearly self-destructing in this match, no doubt CoC will be out for blood.
The Polar Bears will finish their three-game road trip tonight at 9:15 p.m. against CSU Fullerton's Division II team.


The Helm is situated near Oxenholme, just south east of Kendal and although not a very high hill at 185m, it gives beautiful views. Since 2007, we have installed gates improving access on the Helm for all to enjoy. We have also introduced a rare breed of Fell Pony, native to Cumbria. The ponies help with conservation through their grazing as well as creating open ground in their hoof marks so that flower seeds can germinate. Our volunteers are maintaining the dry stone walls that are a part of its character as well as being important to keep the Fell ponies and cows in. We have planted over 1,500 trees, including oak, rowan, birch, wild cherry and hawthorn to create a new wood for people and wildlife to visit all year round.


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Oncology News
Biosimilars have a fascinating story of development and understanding it is crucial for widespread adoption
A Conversation with Rosa Giuliani: Biosimilars are crucial to maximising sustainability and accessibility of cancer care and oncologists want to know more.
Topic: Bioethics, legal and economic issues / Anticancer agents & Biologic therapy
Modern cancer care relies heavily on biological medicines, which have changed the natural history of some cancer types. But the introduction of this sophisticated and expensive therapy means that throughout the world, countries are struggling to provide the best care to their patients. Biosimilars present an opportunity to lower the costs, thereby increasing access in the EU and beyond and contributing to the sustainability of healthcare. Rosa Giuliani, MD, has become a leading figure in this field and, as a medical oncologist, says the most important advantage of biosimilars is that patients currently denied access to expensive biologicals will have the chance to receive treatment. Giuliani is a consultant in medical oncology at The Christie Hospital, Manchester, UK and Chair of the ESMO Global Policy Committee.
An ESMO survey about knowledge and use of biosimilars in oncology has just been published in ESMO Open.
The survey found that three in four (75%) prescribers know what a biosimilar is. Why do you think the remainder don't know?
The concept of biosimilarity is different from what medical oncologists are used to. We understand much better new developments such as immunotherapy, or new targeted drugs, because they have been developed according to what I like to call the "standard paradigm for drug development" – phase I, phase II, phase III – basically looking at efficacy and safety of drugs.
For biosimilars we need to change our perspective. The concept is not having a drug that is safer or more effective but is having a drug that, based on the comparability exercise and the totality of evidence, is highly similar to the originator (also called the reference product). I think that as oncologists we struggle initially to grasp the new terminology. And we struggle to leave the paradigm we have known for drug development.
The survey shows that less than half of prescribers (49%) use biosimilars in their clinical oncology practice. Did this strike you as being very low?
Yes, I was surprised by these low numbers. We also need to keep in mind that the survey was conducted in Autumn 2017. I want to be optimistic, and maybe one explanation could be that when answering the question, responders were possibly focusing more on of the new wave of biosimilars. These are the biosimilars for monoclonal antibodies and are still not available in many countries, so that's why they're not used. In addition, uptake of the first wave of biosimilars in oncology has been extremely low and heterogeneous in different countries and I believe this may be partly explained by the lack of clear and extensive communication about the science behind biosimilars. Therefore, it is now imperative to ensure that the oncology community learns the scientific and regulatory pathways that lead to approval of biosimilars in the EU.
The main concerns oncology prescribers have with switching from a biologic to a biosimilar are the potential for adverse events and increased risk of immune reactions. Are these valid concerns for approved biosimilars?
No, absolutely not. There is no evidence to support these concerns. No biosimilar has been withdrawn by the regulatory bodies because of safety issues, meaning adverse events in general and immunogenicity in particular. Secondly, there are no rational reasons to have immunogenicity problems if the biosimilarity has been ascertained. Because this is the concept – two products that are highly similar cannot trigger this immunogenicity problem.
So, in terms of allaying the concerns, does it come back to understanding the development of biosimilars?
This is a key point. With the introduction of biosimilars, this is the first time the medical community has learned and spoken so extensively about immunogenicity. It was already studied when every biological was developed but we did not discuss it then. So, for me the problem is insufficient knowledge and awareness of the system of development and of the body of evidence the regulators require from companies to support the approval of biosimilars.
"Insufficient knowledge and awareness": the survey clearly revealed some educational priorities in the field. How do you envisage this teaching being delivered?
The majority of responders from every world region highlighted the need to receive further education. There is an acknowledgement of the desire for more information about the process of drug development of biosimilars. Different channels were suggested by responders including face-to-face meetings and quizzes. The main point is that this is not the end of the story, and we need to resolve some issues – for instance extrapolation (1) is the most important one requiring further explanation.
The paradigm for development of biosimilars is totally new compared to what we as medical oncologists are used to. We are aware that it's new, but we need to understand it better. This is an evolving field. Once we understand the comparability exercise and what regulators mean by totality of evidence, we will see that we don't need the phase III trial as a sort of cherry on the cake to show that biosimilars are really similar to the reference product.
I have the impression that now, the phase III trial that is run to confirm the biosimilarity concept is just something we need because everything is novel. But actually, we need to understand that all data that are collected and provided with respect to pharmacokinetics, immunogenicity – the data that are more globally referred to as the comparability exercise and the totality of evidence – are definitely more important compared to the last bit of information which is the phase III trial. I have the impression that without the phase III trial, very few people in the clinical community would have ever accepted biosimilars. So, I think this is something that we need for now. But once everybody is more aware of this new drug development platform, I think that we should also move away from the concept of a phase III clinical trial.
So that should really speed up adoption and development?
Absolutely. Biologics have had an unimaginable impact on the course of cancer and I understand that nobody on earth wants to risk losing this outcome. We really want our patients to be treated in the best way. But I'm sure that if we seriously consider and learn how these drugs are developed, and there is proper education about these drugs, then we will understand this new paradigm for drug development is as good as what we are used to. And that will be a means to save money, because if we do not need expensive phase III clinical trials to show the biosimilarity those are other resources that can be used in the smartest way.
But nearly one in four (24%) prescribers said they do not use biosimilars because they are not approved or reimbursed in their country…
In order to have proper uptake of any therapeutic intervention, and even more in the case of biosimilars, collaboration between different bodies is required. First of all, it needs to be regulated at European level and this is done, from a scientific point of view, by the European Medicines Agency (EMA). Political awareness needs to be raised, in conjunction with political bodies (European Commission), the World Health Organization (WHO), and more importantly scientific societies (ESMO for oncology as well as other organisations). This work that is done centrally should be translated and continued at a national level, in every country, mainly by the national competent authorities and the national oncology societies. And then from the national level it should be translated at the level of the local practice. This is up to us, medical oncologists, playing an active role, not just as prescribers, but understanding the whole system for drug development and being informed and knowledgeable. So, it's an effort that requires collaboration between central and local authorities. And in this context clinicians have a key role in their respective fields.
It seems surprising, given that biologicals are less expensive, that they wouldn't be reimbursed. Maybe people are not satisfied with the evidence for them?
No, I don't think so. I think it's a matter of bureaucracy, which can be different from country to country. When I myself answered this question in the survey I also stated that I was not using some biosimilars, because I was thinking of the monoclonal antibodies that are not reimbursed. So responders possibly focused on the new wave of biosimilars. At the time of the survey in 2017 some were centrally authorised, but even when the EMA approves a drug there is a delay in the uptake of that drug in different countries. That's why it is very important how active the national competent authorities in each member state are.
Less than half (45.2%) of prescribers could define "sensitive indication". What does the term mean and why is it important?
This is almost common sense. If you want to prove biosimilarity you should choose the indication and patient population where the evidence can be collected in an unbiased way. The sensitive indication is the population and line of treatment considered sensitive enough to detect any potential difference between a proposed biosimilar and the reference product. A sensitive population is considered the most representative of the patients for whom the biosimilars, and the biological before, is prescribed. If I want to study a monoclonal antibody biosimilar for breast cancer I wouldn't study a population that is very heavily pre-treated because there are many confounding factors. I will go either for the first line setting or, where it's possible, the neoadjuvant setting. This is a sensitive indication and population. I will also choose sensitive endpoints, which are the measures that will allow me to understand any meaningful difference between the originator and the biosimilar.
What happens if a patient refuses to switch?
In my experience, when patients receive a rational explanation they are reasonable and they understand. It would be interesting to capture this data in clinical practice because I think that some of these problems are more theoretical than practical. In other words, I believe we are anticipating problems that don't exist.
Were there notable differences in responses between prescribers from Europe and the Asia Pacific region?
What I found very interesting is that with respect to the education required, responders from the European region were more interested in knowing about clinical safety and clinical efficacy while responders from the Asia Pacific region were more interested in having specific activities tailored for low income countries. Our Asian colleagues are more comfortable with the concept of extrapolation, meaning we need to raise more awareness within Europe. Responders in both regions were equally concerned about toxicity, but in Europe the concern was more about the immune reaction and in Asia it was about adverse events in general but always in relation with switching.
There are slightly different definitions, regulations, and requirements in different areas of the world. It would be good to have some sort of alignment and harmonisation because drug development is a global process and cancer patients should be offered the same level of care wherever they live.
(1) Extrapolation is the approval, by a regulatory agency, of a biosimilar in one or more indications of the reference biologic without the requirement to carry out clinical trials of the biosimilar in all those indications.


Besthorn, Fred H. "Speaking Earth: Environmental Restoration and Restorative Justice." In Restorative Justice Today: Practical Applications, edited by Katherine S. van Wormer and Lorenn Walker, 233-244. Thousand Oaks, CA: SAGE Publications, Inc., 2013. doi: 10.4135/9781452244228.n25.
Besthorn, F H 2013, 'Speaking earth: environmental restoration and restorative justice', in van Wormer, KS & Walker, L (eds), Restorative justice today: practical applications, SAGE Publications, Inc., Thousand Oaks, CA, pp. 233-244, viewed 19 April 2019, doi: 10.4135/9781452244228.n25.
Besthorn, Fred H. "Speaking Earth: Environmental Restoration and Restorative Justice." Restorative Justice Today: Practical Applications. Eds. Katherine S. van Wormer and Lorenn Walker. Thousand Oaks: SAGE Publications, Inc., 2013. 233-244. SAGE Knowledge. Web. 19 Apr. 2019, doi: 10.4135/9781452244228.n25.
Fred H. Besthorn, associate professor of social work at Wichita State University, has written widely on the subject of deep ecology, which takes us into the spiritual realm with a deep appreciation for nature and for nonhuman and human life. In his contribution for this book, Besthorn constructs a model of environmental restoration as a form of environmental justice. Because we depend on nature, as the author suggests, we must work toward restoring a harmonious balance between our lifestyles and our natural resources. You don't have to be familiar with all the philosophical terms used in this contribution to appreciate the essence of its argument.


text:
Q: Resharper c++ does not display squiggles for error or warning I'm using Resharper C++ 2022.3 on VS2022.
Example in Vanilla VS
When typing inappropriately, In vanilla VS, display redline squiggle as above.
Example in Reshaper
but when using Resharper, don't display squiggle as above.
so, I want to see redline for error like vanilla while using resharper.
How can i solve this problem?
Tools > Text Editor > C/C++ > Advanced > "Disable Error Reporting" is False,
and Resharper option > Editor > Visual Studio Features > "Hide Visual Studio squiggles" is unchecked

A: When "Hide Visual Studio squiggles" is unchecked, VS error squiggles should be shown even when ReSharper is running. There's a bug in the 2022.3 release however which causes R# to hide VS squiggles. Hopefully it should be fixed soon, you can vote for the issue to subscribe for notifications.
Regarding R# not showing an error in your code, that's another issue which is already fixed internally and the fix will be available in R# 2023.1.


text:
<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN" "http://www.w3.org/TR/html4/loose.dtd">

<META http-equiv="Content-Type" content="text/html; charset=utf-8">
<TITLE>
ReconnectRequest (xmemcached 1.3.0 API)
</TITLE>

<META NAME="date" CONTENT="2011-01-04">

<LINK REL ="stylesheet" TYPE="text/css" HREF="../../../../stylesheet.css" TITLE="Style">

      Overview
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net.rubyeye.xmemcached.impl

Class ReconnectRequest

java.lang.Object
  net.rubyeye.xmemcached.impl.ReconnectRequest

All Implemented Interfaces:
java.lang.Comparable<java.util.concurrent.Delayed>, java.util.concurrent.Delayed

public final class ReconnectRequest
extends java.lang.Object
implements java.util.concurrent.Delayed

Auto reconnect request

Author:

dennis

Constructor Summary

ReconnectRequest(InetSocketAddressWrapper inetSocketAddressWrapper,
                 int tries,
                 long reconnectInterval)

Method Summary

 int
compareTo(java.util.concurrent.Delayed o)

 long
getDelay(java.util.concurrent.TimeUnit unit)

 InetSocketAddressWrapper
getInetSocketAddressWrapper()

 int
getTries()

 void
setInetSocketAddressWrapper(InetSocketAddressWrapper inetSocketAddressWrapper)

 void
setTries(int tries)

 void
updateNextReconnectTimeStamp(long interval)

Methods inherited from class java.lang.Object

clone, equals, finalize, getClass, hashCode, notify, notifyAll, toString, wait, wait, wait

Constructor Detail

ReconnectRequest

public ReconnectRequest(InetSocketAddressWrapper inetSocketAddressWrapper,
                        int tries,
                        long reconnectInterval)

Method Detail

getDelay

public long getDelay(java.util.concurrent.TimeUnit unit)

Specified by:
getDelay in interface java.util.concurrent.Delayed

compareTo

public int compareTo(java.util.concurrent.Delayed o)

Specified by:
compareTo in interface java.lang.Comparable<java.util.concurrent.Delayed>

getInetSocketAddressWrapper

public final InetSocketAddressWrapper getInetSocketAddressWrapper()

updateNextReconnectTimeStamp

public void updateNextReconnectTimeStamp(long interval)

setInetSocketAddressWrapper

public final void setInetSocketAddressWrapper(InetSocketAddressWrapper inetSocketAddressWrapper)

setTries

public final void setTries(int tries)

getTries

public final int getTries()

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Copyright © 2011. All Rights Reserved.

redpajama_set_name: RedPajamaGithub


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text:
← Another author interview
New Release: Payback Time →
The Great Indie Publishing War of 2013
It all started at Salon, when a writer called John Winters stated that he was a self-publishing failure and also likened self-publishing to masturbation, which naturally did not go down all that well with many indie writers. Never mind that Winters' novel, a thriller called Murderhouse Blues, is uncommonly expensive for an indie published e-book and appears to have been published only two days before the article went live. Now two days is not a lot of time to decide you're a failure, though maybe he revamped and republished his book.
At Terrible Minds, Chuck Wendig responds to John Winters and points out that self-publishing is not a "get rich quick" scheme and that you probably won't be successful, if you don't have some kind of network, platform or social media presence.
Also at Salon, Hugh Howey, one of the big indie success stories, responds and points out how many largely unknown indie writers are nonetheless making decent money and finding success.
Chuck Wendig responds again, this time to Hugh Howey, and says that there is no one true way, but various paths to publishing success (or failure). Being Chuck Wendig, he uses a lot more expletives, though.
After a brief excursion to the Kindleboards, which he did not find too welcoming, Chuck Wendig posts about his adventure there and repeats his points why in his opinion indie is not always the best option for everyone. With this post, he actually lost me, because I have read that thread at Kindleboards (at least at the beginning – it's a long thread, though Chuck left before I did) and with one or two exceptions, most posters were actually quite welcoming to Chuck, while still pointing out that as far as they were concerned, indie publishing was the best way for them. Which is only to be expected at a forum for self-publishers.
Now Kindleboards can be problematic at times and some posters drive me up the wall with their ultra-commercialist, "I'll do anything to sell" attitude, as do posters dispensing craft advice that is basically regurgitated (and misunderstood) Strunk & White. Bonus points, if they sell editing services. But that said, Kindleboards is still full of helpful information for the indie writer. You just have to take it, like everything else, with a grain of salt.
Meanwhile, YA writer Susan Kaye Quinn responds to Chuck Wendig and says that she leans towards the philosophy of "indie publishing first" these days, even though there are cases where trad publishing is the better option.
A little bit before the Winters/Wendig/Howey exchange, another SF writer, Charles Stross, posted his reasons why he does not self-publish. In short, he feels that the things his publisher does for him are things he couldn't do himself or outsource.
Now, Linda Nagata responds in a guest post on Charles Stross' blog why she decided to self-publish (first backlist and then a new book) and why she feels it's the best decision for her.
Meanwhile, at the Guardian, which has not exactly been a hotbed of pro-selfpublishing articles in the past, Alison Haverstock lists ten ways that self-publishing has changed the world for the better. This is a surprisingly good and even-handed article, particularly given the sniping and negative attitudes displayed in some of the posts above.
This entry was posted in Books, Links, Publishing and tagged gloom and doom, indie publishing, indie versus traditional, indie wank, other people's books. Bookmark the permalink.
3 Responses to The Great Indie Publishing War of 2013
Pingback: The latest state of this year's awards debate | Cora Buhlert
Eli N. Wade says:
One of the best things about the modern world of publishing is that there is more good stuff available, and it's easier to get hold of, than ever before. Small press and boutique publishers are springing up everywhere and, along with indie and self-publishers, they're giving the "big six" more of a run for their money than ever before. I think this is great, as it really does give an outlet for pretty much anything. There are still gatekeepers in the form of all the hard-working editors at those small and boutique presses. Hopefully there's still control in content from the self-publishers, as they should be employing editors and proof-readers and cover designers to make their work the best it can be. Of course, a lot aren't and, whether indie, small press or big six, there's an awful lot of shit out there.
Susanne M. Cabrera says:
What I want to do, however, is to talk a little more about this "indie first" path — the path that Howey and others feel is the best way forward for new authors. This was also echoed a number of times at the Writer's Digest East Conference, where I spoke this past weekend. Lots of folks were suddenly presenting self-publishing less as a standalone option and more as the new gate (kept or unkept) leading to traditional publishing. Self-publish first, they say, and get attention and audience. You can even query the published story while it sells on the digital marketplace.


Hanged out in Hakata with my old friend. Went to Cafe Espressamente Illy.
We did a gift exchange as usual.
She gave me lovely cosmetics from Paris and a few books.
This flower shape is actually a cheek powder. So cute.
over a lunch and a cup of tea.
-Carries Turkish kilm cushion. Grilled mackerel sushi was so delicious!
-Spacious ocean view modern villa located in a gated community up on the deep hill.
The exhibition between March & June is "Mother & Child".
All monochromatic photos are from around 1950s. A young mother, old mother, modern mother, tough mother, mother with refined kimono, all different mothers with their kids from the era are pictured in a nostalgic setting just like an old movie scene. I couldn't help imagining the stories behind these photos. A kite was flying around in the blue sky holding a piece of paper or towel.
The folk guitar club my mom belongs to performs live concerts at local retirement centers almost every month. This one just happened the other day at the elderly care center called "Nukumori" -meaning warmth that is a beautiful ocean front building in Kanesaki. Some audiences were singing cheerfully while the others were dozing off comfortably during the performance. It was a perfect sunny day for the event by the sea.
Another lovely event was a lunch on a sunny (but a bit windy) day at the ocean view Italian restaurant called "Gashiyo del mare" in Fukutsu. We invited the staff of the mother-daughter party. They were such a big help.
We ordered the same course but each of us was served a different dessert at the end, which was a sweet surprise.
Fukuma beach has changed a lot since I was growing up. There are some more cafes that I want to stop by some other time.
Back at home. These yummy looking sweets are from my customer who wanted to custom-order a ring. What a pretty gift. We discussed about the design over a cup of tea and a piece of cake.
A hydrangea reminds me of a rainy season but this one is in full bloom quite early.
Getting back to work gradually after the big event.
I realized that not many older Japanese women have their ears pierced while my earrings are all pierced style. Some asked for replacing to clip-on and the others decided to go to get their ears pierced later after the event ,which was so adorable and made me smile. My wish is to create something that bring cheers and charms to wide range of age groups.


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text:
1. Salman Khan, along with his co-stars from the Bollywood film Hum Saath Saath Hain (We Are Together), are accused of killing rare antelopes known as blackbucks and chinkaras during the shooting for the film in 1998. The blackbuck is an endangered species protected under the Indian Wildlife Act.
2. Bollywood actors Saif Ali Khan, Sonali Bendre, Tabu and Neelam — mall co-stars of Salman Khan for the Sooraj Barjatya film, are accused of accompanying the actor and being present in the vehicle when Khan shot the blackbucks in Kankani village near the western Indian city of Jodhpur. All four of them were acquitted of the charges on Thursday.
3. In February 2006, Khan is convicted under Section 51 of the Wildlife Act and given a one-year jail term, for killing two chinkaras at Bhavad village in Rajasthan in September 1998 during the shooting for the same film. The jail term is overturned after an appeal.
4. In April 2006, a Jodhpur sessions court gives Khan a five-year-sentence in the second chinkara case, where he was accused of hunting a blackbuck in Ghoda farms. Khan spends three days in jail after which he is granted bail. In November 2013, the Rajasthan High Court suspends the five-year sentence given in April 2006. But in January 2015, the Indian Supreme Court sets aside Rajasthan High Court's stay on the sentence.
5. In June 2006, a local Jodhpur court frames charges against the actors in the third case. The charges were framed against Salman Khan under Section 51 (hunting) of the Wildlife Protection Act and against actors Saif Ali Khan, Tabu, Sonali Bendre, Neelam and local resident Dushyant Singh under Section 52 (abetment) of the Act.
6. In July 2016, the Rajasthan High Court acquits Khan in the two chinkara poaching cases, observing that there was no evidence to prove that the animals who were found dead were shot by the actor's gun.
7. The blackbuck shooting took place near a village of Bishnois, a community known for its fierce protection of wildlife. According to villagers, they heard the gunshots and found the blackbucks' carcasses. They are said to have chased the vehicles in which the actors were present but they drove away. However, Khan's lawyer claimed there was no forensic evidence that the deer were killed by guns as no bullets were found.
8. The police filed a case against Salman Khan in October 1998 under the Arms Act for possessing and using unlicensed rifle and revolvers and using them for poaching the blackbuck. But a chief judicial magistrate in Jodhpur acquit the actor on January 18, 2017, saying the prosecution had failed to prove the charges against him.
9. Slamming Khan as a "habitual offender," Jodhpur chief judicial magistrate Dev Kumar Khatri finds Khan guilty and sentences him to five years in jail yesterday.
10. Khan has had other brushes with the law. In 2014, the Bombay High Court acquitted Salman Khan in a drunken-driving, hit-and-run case. The judges found that prosecutors had failed to prove charges of culpable homicide, in which they accused Khan of driving while intoxicated in 2002 and running over five men sleeping on a sidewalk, killing one of them. The government of Maharashtra state, of which Mumbai is the capital, has challenged his acquittal in the Supreme Court.
MPs consider resigning as Andhra Pradesh protest intensifies
'Demonised' pasta may be recipe to help weight loss


I live on the outskirts of Indianapolis, Indiana in Brownsburg with my husband Rob, and our wonderful kids.
I'm a southern lady at heart, but I like to think I've adjusted well. I do like late night food take out, and the snow is even a welcome treat at times.
My exhausted husband after a short and intense 3.5 hour labor with Henry.
People say that when I laugh, my eyes disappear. In my downtime you can usually find me laughing, coffee (or wine) in hand.
After a traumatic first birthing experience with my daughter nearly ten years ago, my son's natural and gentle birth in 2016 was so, so healing and empowering.
I feel like every mother-to-be has a fire waiting to be lit. When motherhood is in full bloom...that's when it ignites. You feel it engulf you in that very moment. It is a good thing.
I know what it's like to go through life overly-anxious. We all struggle with some things. In a way, I find that that is what makes us beautiful; the things we overcome.
By providing lucidity to your birthing story - on the day you bring your baby into this world - my antidote is formed by witnessing you powerfully birth into distinct and raw motherhood.
i'm not afraid, and you shouldn't be, either.


text:
Top 25 Food-Related Quotes Of The Past Decade
Dave Faries December 8, 2009 12:13PM
Almost a decade ago, I wrote this: "Every time this country ends up with a Bush in the White House, several things most assuredly occur: The government inflicts some regrettable incident on Japan, the nation tumbles into a recession, a presidential pet writes a book, and everyone worries about the vice president's ability to run things. We're still awaiting the inevitable war..."
Not bad. Beats my only other quotable line, which was "the mere thought of marinating a brain overnight in the fridge just bugs most people."
In thinking through a decade of excess, recess, war and lunacy, we decided it was best to forget about analysis and allow chefs, managers and others associated with the restaurant industry put it in their words. Or, more precisely, we decided to pull some of our favorite comments from the past ten years.
Our criteria? Well, they had to be quotes we recorded during interviews. That's about it.
And so you're about to learn about Nick Badovinus' disturbing bacon fetish, what Kent Rathbun really thinks about creme brulee and Marc Cassel's thoughts on his 'member.'
Well, sort of
So here are the 25 most memorable comments of the 00s:
25 Tre Wilcox
"In my opinion I really don't have an opinion."
The question had to do with the various qualities of free range, grass fed beef weighed against the more common grain finished. When he said this, the future TV star and Loft 610 headliner was working with Kent Rathbun at Abacus.
24 Kent Rathbun
"It's not too creative and motivating to work with steak. For a pastry chef, creme brulee is like that. It's just vanilla custard with sugar on top."
I forget what we were talking about--menu items you see everywhere or something like that. The venerable chef is always good for a memorable comment.
23. James Neel
"It's edible, but I don't think I'd run out to the store and buy any."
The chef of Tramontana was discussing head cheese prepared by Brian Luscher for a macabre taste test: haggis, scrapple and the aforementioned.
22. A waitress at Chili's
"People ask me, 'don't you get hungry seeing all of that food all the time?' Yeah, when I bring the food out it looks good, but not when I clear a table of half-eaten scraps."
Speaks for itself, really.
21. Garreth Dickey
"Even at home I wouldn't mold my couscous into a circle and put my lamb on top."
At the time, Dickey was chef at Tucker--an underappreciated spot. We were discussing how the desire to present dishes in the most appealing light led to tall foods and other horrendous trends.
20. Joel Harloff
"It's hard to get people in Dallas to eat wild game. It seems they'd rather just shoot it."
Then chef for Landmark and the Melrose Hotel, Harloff was lamenting the fact he couldn't sell rabbit and other such meats--even though he tried several times.
"You can do tuna a zillion different ways. But everywhere I see it, it's seared and served with some soy-wasabi mixture."
This time, Dickey was running the kitchen at a place called Jeroboam. Really, I can't remember what question prompted the response. It was seven or eight years ago, after all. Still not sure about his math, though.
18. John Fowler
"Most people don't look that closely, but it adds to the je ne sais quoi."
This came up during a discussion with Fowler, at the time manager of Flying Saucer in Addison, about decor. If you've never been, the pub has a wall festooned with old plates. This apparently makes people think classy.
17. Maria Sotolongo
"I'm not particularly fond of cow parts, but I like rabbit."
The former Fox 4 weather babe was speaking about organ meats when we recorded this. Her brother, she said, owned a tapas spot in Houston and she loved the open-minded, Spanish approach to food. Just not certain parts of it.
16. Waitress Lauren Zindel
"Chewing with their mouth open and talking while they chew--it's disgusting. Of course, if they tip well I can put up with their chewing."
The topic was diner faults, which brought out some interesting commentary from wait staff. One even remembered a guest who kept spitting into the ashtray. Hmm...ashtray--that shows the age of this quote.
Nick Badovinus
15. Nick Badovinus
"Besides figuring out how many different ways I could fit the F-word into sentences, not well."
When asked how he managed to cope when the flat-top stove at Cuba Libre decided to shut down during lunch rush one afternoon many years ago. Keep in mind, the place has an open kitchen. Must have been quite a show.
14 Lisa Kelley
"You get burns, you slice fingers, your hair is a mess and the chef's jacket makes you look three times the size you are."
Back in 2003, this was how the executive chef at Hattie's sized up life in a professional kitchen.
13 Louie Canelakes
"I think anything with a theme is bogus. Our theme is food and drinks. The customers have to fill in their own blanks."
The owner of Louie's was speaking to the question of real dives versus fake dives. But he says so much more.
12 Gilbert Garza
"It doesn't say whether it was a healthy goat."
The Suze chef said this while examining the label on a container of supermarket goat cheese I'd placed in front of him--and after he'd taken a taste.
11 Neil Taylor
"If they want garlic in their mashed potatoes, I'll put garlic in them. If they want the skin off, well, they can go to Popeye's."
This comment comes from March of 2001, when Taylor served as manager of Good Eats in Addison, famous (I guess) for skin in their mashed potatoes.
10 Russell Hodges
"These are the last days. In the last days, you will see a chipotle barbecued Peruvian potato. That's in the Bible."
Prophet--and also chef--Hodges ran the kitchen at Iris when he declared our doom, well ahead of those 2012 folks. Not to take him literally, but his point was more about pushing fusion beyond the limits.
9 Gilbert Garza
"It may be worth it, but it depends on what you're going to do with the butter."
Let's see...there's cooking with it, spreading it on biscuits. What else? The chef, by the way, was talking about expensive brands.
8 Marc Cassel
"I've worked in many kitchens where it's been just sports and dick jokes. It's hard to defend our gender sometimes."
This was from the days when people crowded into Cassel's Green Room, addressing the reason why there are more male chefs.
7 Sharon Hage
"Isn't it better to eat really good bologna than really bad steak?"
Don't remember what York Street's chef was speaking about, but right on.
6 Bob Sambol
"You want to see some pink."
Yes, he was speaking about steak. Just fun to take it out of context.
5 Aaron Staudenmaier
"I like places where my expectations are zero."
This from a chef who, at the time, ran operations at Jasper's for Kent Rathbun.
4 Joel Harloff
"It's like a big bucket of snakes. They're slippery and slimy and round. You have to have a good knife and a lot of patience."
He said this when working as chef for Mi Piaci, so it's going back some. What was he talking about? Killing and skinning eels, of course.
3 Mari Woodlief
"It's a big, solid piece of metal that comes between you and your food."
The political adviser took a moment to share her opinion of spoons back in October of 2000, when the decade was young.
2 Nick Badovinus
"Based on experience, bacon fat will render at 98.6 with a little friction."
Really, you don't want to pry further.
"You can fry a turd and it tastes good."
Again, you don't want to know more. But over a decade of showy opulence, hard door clubs, big steakhouses, economic collapse, comfort food and small neighborhood joints, this is the number one comment.
Congrats chef.
And we'll end with something I wrote--don't know why--back in February of 2003:
They say history proves again and again how nature points out the folly of men.
In this case, "they" are Blue Oyster Cult, a band from the days of open shirts and infinite hair. We're not certain whether they are the "they" mentioned in all the other "they say" references, such as "they say it causes blindness," but they are definitely the "they" who warned us of the potential for great frustration when men step outside their league.
This week's Burning Question, you see, exposes man's fascination with the unattainable. As children, we learn that achievement comes through effort. Everyone, wrote English author Samuel Butler, "can in the end get what he wants if he only tries." But like Tom Hanks waving bye-bye to the moon or Columbus tumbling off the edge of the earth, we eventually discover--Butler's words, again--that every individual is more or less an exception to that rule. In other words, The Little Engine That Could is just a damned lie that perpetuates class...must calm down...In other words, all the striving in the world, the quest for success or glory, generally nets you only a cubicle in a room of cubicles in a building of rooms.
Be that as it may, we beat on.
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(Brussels, 12/06/2015) CONCORD, the European confederation of Relief and Development NGOs, held its General Assembly on 10-11 June in Brussels, with three new organisations joining as well as board elections taking place.
The 'Child Fund Alliance' and 'Habitat for Humanity International' joined as international networks with 'EAEA' (European Association for Education of Adults) joining as associate member. This brings CONCORD membership to 28 national platforms – one per EU member state – and 20 international networks, plus 3 associate members.
At this year's General Assembly, two board members were re-elected: Rudy de Meyer from CONCORD Belgium and Marina Sarli from the Hellenic Platform of NGOs.


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Culture Entertainment
'Shadowhunters' Dominic Sherwood finds the magic in tech
Dominic Sherwood talks to CNET about the cool tech on the unique Netflix series.
Jennifer Bisset
July 14, 2017 9:00 a.m. PT
Jennifer Bisset Senior Editor / Culture
Jennifer Bisset is a Senior Editor for CNET. She covers film and TV news and reviews. The movie that inspired her to want a career in film is Lost in Translation. She won Best New Journalist in 2019 at the Australian IT Journalism Awards.
Expertise Film and TV Credentials Best New Journalist 2019 Australian IT Journalism Awards
"Shadowhunters" is a curio on Netflix for two reasons. The first is that it's the only Netflix series released weekly, made available for streaming the day after episodes air on Freeform in the US. The second is its mashup of magic and technology.
I went for the obvious when I asked Dominic Sherwood, who plays Jace, a demon-punching-kicking-and-slashing Shadowhunter, what he would prefer, tapping technology or slinging magic.
"Probably magic," he said. "Just 'cause why wouldn't you? The amount of times I've been trying to make a phone call and I've got literally no bars or no service and my battery dies. Why wouldn't I just use a Seelie communication ring, have Magnus teleport me to wherever it is and have a conversation with that person. That would always by my choice. Always."
"Shadowhunters" is a TV adaption of "The Mortal Instruments" series of young adult novels by Cassandra Clare, following Clary Fray and half-angels known as Shadowhunters who protect normal people from dark forces. You might remember the movie "City of Bones" that came out in 2013, based on the first book. It didn't summon the magic of other young adult series like "Hunger Games" or "Divergent," yet despite the cancelled sequel, fans could eat up a TV series that rebooted the events of the first book, finding an all-new cast that jumped into a second series, with a third recently announced.
More on Netflix
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Aside from Seelie communications rings and help from the High Warlock Magnus Bane, Shadowhunters use mobile phones, GPS trackers, sophisticated touch screens with high-tech maps and even a concentrated UV laser a la James Bond (that one's for torturing-vampire use only). You might ask why these fearless demon-chasers need gadgetry when they've got an all-powerful magic wand in their back pocket.
"This is actually something that we talk to them about quite often," Sherwood said, referring to the showrunners. "We only really seem to use GPS when we need a problem to happen with it. We use it and then I find myself thinking why didn't we just use Magnus? He's all-powerful."
He concludes that the use of technology, while a part of the books, is often called on for a certain purpose in "Shadowhunters." "So the line seems to be circumstantial for when it suits the show," Sherwood said.
So basically, it doesn't have to make sense.
"Shadowhunters" may or may not use technology when it suits the show.
Facebook/Shadowhunters
One of the intriguing parts about "Shadowhunters" from a tech-fantasy standpoint is where the show can advance from the books. This season has new showrunners, Todd Slavkin and Darren Swimmer, who previously helmed "Smallville". Sherwood says the response has been "resoundingly positive" and "there was definitely a change, kind of a more deeply impactful show."
So where can tech on the show veer from that in the books?
"Cloning is good tech," Sherwood said. "I think we should do that and then I could just clone myself seven times... and then we'd end up with a Dom battle royale. I'll end up... systematically hunting and killing these Doms."
It's not just the show finding inspiration in the technological advancements of current times. That road is two-way.
"You end up with that weird complex that people have been talking about for a long time whether it's TV or media that inspires technology or vice versa. So it would be interesting to see if this ever does come out in the future and whether it was science fiction that inspired it or whether it was already being worked on and the technology ideas inspired the science fiction. I guess we'll just have to wait and see. It's an exciting time."
"It's not just the show finding inspiration in the technological advancements of current times. That road is two-way."
Dominic Sherwood
"Shadowhunters" isn't the only Netflix content speaking to those themes. The recent film "Okja" may be tapping into current developments in cloning and gene manipulation. The film's animal creation, the superpig, is bred to leave a smaller environmental footprint while feeding the masses. In real life, a biotech company in China has successfully cloned a dog using gene editing, which raises questions around the ethics of cloning. While "Okja" addresses topics like animal welfare and rights, "Shadowhunters" touches on addiction, homosexuality and prejudice, that "deeper impact" stemming from the second season's new ambitions.
Netflix affecting the fans and the actors
Instead of ruing the show's episodic release (like some of us impatient people), fans having to wait for new episodes have been affected in positive ways.
"That's really rough sometimes, but I think because it's only a day what we've managed to do is unify worldwide fans," Sherwood said. "I look at my Twitter and I find that there are people from Germany talking to Australians or there are people from Spain talking to Latin Americans. They're talking to people that they've never met before but they have this unified enjoyment, love of our show, which is really nice to see."
But that can make things tricky for Sherwood, a Brit, in his interaction with fans in the UK.
The episodic release of "Shadowhunters" on Netflix affects fans in positive and negative ways.
John Medland
"If we live tweet on Monday with fans we feel like we're giving stuff away for people who can't watch it until Tuesday. And especially being a Brit, that's really tough when my British fans are like, 'we can't watch it yet,' so I almost feel like I'm betraying the homeland."
Most importantly, I ask Sherwood if he's bingeing anything on Netflix. He answers with "Archer" and "American Horror Story." "13 Reasons Why" stands next on his watch-list, though he's aware of it being emotionally-taxing. "I've got to be in the right emotional head-space for it," he said. "I don't know if I need another show that's gonna make me blub, cry for another 13 episodes. I do enough of that on my show."
I have to ask what's to come for Jace and the show. There are tears (Jace's, not mine -- not yet). I'm not confident Jace is going to be OK.
"There's some real heartache on its way. Physical, emotional heartache, from a bunch of different characters. There's some great book stuff coming in, the ending is some really cool stuff from the books. Some of our new characters get explored a little bit more, some relationships get tried and tested."
Stream new episodes of "Shadowhunters" season two every Tuesday on Netflix internationally.
Star Wars at 40: Join us in celebrating the many ways the Force-filled sci-fi saga has impacted our lives.
Life, Disrupted: In Europe, millions of refugees are still searching for a safe place to settle. Tech should be part of the solution. But is it? CNET investigates.


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Q: How to output JSON parse compatible json with PHP json_encode? JSON.parse - Unexpected token h due to single escaped double quotes I have this php:
<?php

    $jsonarr = array("haha" => array("hihi'hih","hu\"huh"));
    print json_encode($jsonarr);

This gives me
{"haha":["hihi'hih","hu\"huh"]}

Now, in JSON.parse this breaks with
Uncaught SyntaxError: Unexpected token h
    at Object.parse (native)

, unless I double escape the backslash like this
var json = '{"haha":{"hihi\'hih":"hu\\\"huh"}}';
JSON.parse(json);

How can I get php to create a JSON parse compatible output?
Meanwhile, I did get this to work with double json_encoding the string in php based on this PHP's json_encode does not escape all JSON control characters like this, but wonder if there is some other way.
$jsonarr = array("haha" => array("hihi'hih","hu\"huh"));
        print json_encode(json_encode($jsonarr));

A: If you were getting this from AJAX, it wouldn't be happening, so I believe you're generating JS code using PHP, something like this:
var json = '<?php echo $jsonarr; ?>';
var obj = JSON.parse(json);

This won't work, because, as you noted, $jsonarr when printed will not have the requisite number of backslashes. \" in JSON needs to be \\" in a JS string literal in order to be understood as \".
Instead, remember that JSON is executable JS:
var obj = <?php echo $jsonarr; ?>;

Done!


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The primary role of the NMR Facility is to provide research support to IQAC staff and students; however, its services are available to anybody. Staff of the NMR Facility provide a range of consulting services, technical assistance and training.
Double/Triple resonance experiments for peptides/small proteins.
NMR spectra of cells, cell extracts, and metabolomics-by-NMR.
1H NMR experiments, including basic processing and integration.
31P NMR, 13C NMR and 19F experiments.
Structure elucidation and quality control in synthetic chemistry by solution 1D/2D-NMR.
Facility staff will provide NMR service (data interpretations, recommendations) for a fee to any person or organization.
– Bruker AVANCEIIIHD 500 MHz (11.7440 T field strength) with TCI Cryoprobe and SampleXPressLite 18-charger. This system is the NMR spectrometer of choice for more demanding samples and is highly suited for metabolomics studies, the study of complex biomolecules like small proteins, peptides and nucleic acids, and routine 1H and 13C NMR experiments on small molecules when tiny amounts of material are available. The spectrometer is equipped with a three-channel AVANCEIIIHD console, z-gradients (55 G/cm) and an inverse detection TCI (1H, 13C and 15N) cryoprobe, with 1H and 13C direct detection, 13C and 15N indirect-detection. The spectrometer uses Topspin 3.7 software on a Linux Workstation.
This NMR system was purchased with financial support from MINECO-FEDER CSIC13-4E-2076 grant.
Puig-Castellvi, F., Perez, Y., Piña, B. Tauler, R. and Alfonso, I.
Chem Commun. 54 (25), 3090-3093, 2018.
Aguiló, E., Moro, A..J., Gavara, R., Alfonso, I., Perez, Y., Zaccaria, F., Rodriguez, L.
Inorg Chem. 57(3), 1017-1028, 2018.
Perez, Y., Gomara, M.J., Yuste, E., Gomez-Gutierrez, P., Perez, J.J, Haro, I. Chemistry-A European J. 23(48), 11703-11713, 2017.
Arbesu, M., Maffei, M., Cordeiro, T.N., Teixeira, J.M.C., Perez, Y., Bernado, P., Roche, S. , Pons, M. Structure 15, 630-640, 2017.
Corredor, M., Bonet, R., Moure, A., Domingo, C., Bujons, J., Alfonso, I., Perez, Y. and Messeguer, A. Biophys J. 110 (6), 1291-1303, 2016.
Faggi, E., Perez, Y., Luis, S.V. and Alfonso, I. Chem Commun. 52 (52), 8142-8145, 2016.
Alcaide, A., Trapero, A., Perez, Y. and Llebaria A.
Org & biomolec chem 13 (20), 5690-5697, 2015.
Vasconcelos, A., Vega, E., Perez, Y., Gomara, M.J., Garcia, M.L. and Haro, I. Int J Nanomedicine 10, 609-631, 2015.
Galatola, R., Vasconcelos, A., Perez, Y., Cruz, A., Pujol, M., Alsina, M.A., Gomara, M.J. and Haro, I.
Eur J Med Chem. 2014 86, 589-604.
Perez, Y., Maffei, M., Igea, A., Amata, I., Gairí, M., Nebreda, A.R., Bernadó, P. and Pons, M. Scientific reports 3, 1295, 2013.
Perez, Y., Maffei, M., Amata, I., Arbesu, M. and Pons, M. Protocol Exchange 10, 2013.


Somewhere between city, coast and country is this gorgeous rustic retreat. Our Kelvedon Hatch glamping site is the perfect place to get back to nature. Unearth local treasures, spend a day by the seaside or head into the capital for a whirlwind tour of bright lights and must-see sights.
Back at base, you'll find a comfortable retreat that's worlds away from the traditional camping experience. Glamping is all about the finer side of the great outdoors, with real beds, cosy furnishings and your own decked terrace. Kelvedon Hatch campsite is a great spot that's with showers, a parent and child room, children's play area and plenty of handy facilities.
Tucked away in a quiet corner of rural Essex, glamping at Kelvedon Hatch places you within easy reach of so many fascinating and beautiful places. Hold up a finger and go wherever the mood takes you. Local favourites include the pretty village of Kelvedon Hatch where, believe it or not, is a secret Cold War bunker and a Regional Government HQ. It's now a museum, so you can take a revealing tour and learn about its little-known past as a would-be nuclear hideaway. The leafy town of Brentwood (better known for its starring role in The Only Way is Essex) is just four miles away, offering a hubbub of shops, cafes, bars and restaurants. Somewhere in the midst of Brentwood's perfectly dressed shop windows and bars are the ruins of a 12th-century chapel in the centre of town. Other local must-sees include Mountnessing Windmill - a restored, working mill built in 1807 - and Old MacDonald's Farm, a children's petting farm with indoor play centre.
Our Essex glamping site boasts a cracking location for day trips. Over near Toot Hill is the beautifully kept Greensted Church, which bears the remarkable title of the world's oldest wooden church. Half an hour's drive away is RHS Garden Hyde Hall, one of the finest gardens in the East of England with fantastic panoramic views of surrounding hills and farmland. Rich in biodiversity, Hyde Hall is a sprawling 360-acre estate with glorious surprises to explore around every corner.
The beaches and amusements of Southend-on-Sea are less than an hour's drive from Kelvedon Hatch. This seaside resort offers a great day out with seven miles of seafront, an Aquarium and Adventure Island. The Essex coast is also home to numerous Blue Flag beaches including Shoebury beach and Canvey Island in the Thames Estuary.
For a day in London, there are regular trains from nearby Brentwood to Liverpool Street Station. Buses to Brentwood stop half a mile from Kelvedon Hatch campsite with trains departing every 10 minutes to the city.


text:
One for the Gipper
Lou Cannon's New Book Assesses Bush Jr. Through Reagan's Legacy
By Barney Brantingham
Thu Jun 05, 2008 | 6:00am
Lou Cannon
Sue De Lapa
During his 2000 campaign and after his election, George W. Bush and his aides talked of modeling his administration after that of former president Ronald Reagan. The authors of Reagan's Disciple ask: Did George Bush steam full-speed ahead with the so-called "Reagan Revolution"-or derail it?
Reagan biographer Lou Cannon of Summerland and his journalist son Carl examine both presidencies in detail but keep coming back to the fact that Bush started a foolish, unnecessary war while Reagan carefully avoided plunging the nation into such a mess.
That, in a nutshell, is Bush's legacy-and Reagan's. There's good reason to think that the Gipper was too cautious to have invaded Iraq, no matter how much he despised Saddam Hussein. Reagan, however, certainly would have watched for solid evidence of Hussein's efforts toward nuclear weapons production, as opposed to the flawed intelligence Bush was all too eager to act on. We're told that "ultra-conservatives" in the Reagan White House wanted to send troops into Nicaragua after Congress cut off aid to the Contras, but that Reagan refused. "Those sonofabitches won't be happy until we have 25,000 troops in Managua, and I'm not going to do it," chief of staff Ken Duberstein quoted Reagan as saying.
"Bush was Reagan's disciple, to be sure," the authors say, "but he did not face the seminal crises of his administration-especially the Iraq War-with the blend of principle and pragmatism that was the hallmark of Reagan's dealings with the Soviet Union.
"We do not fault Bush's intentions, but noble intentions do not excuse his performance in Iraq or the domestic failures of his second term. Nor do they explain his refusal to learn from his mistakes."
The Cannons are not liberal Bush-bashers-far from it. They generally give both Reagan and Bush the benefit of the doubt in many instances. Conservatives writing about other conservatives do not always strike sparks. Still, this is a highly detailed and intelligent analysis of two presidents, men of far different temperaments.
Both presidents, although railing against "big government," ran up huge deficits, red ink that Bush is still writing his budgets with. Both cut taxes, leading in part to the deficits, their critics say.
"There are two principle reasons why conservatives have soured on George W. Bush," the authors observe in a preface. One is uneasiness about the war. The other is Bush's blithe embrace of deficit spending, necessitated, in part, to finance that war.
The Cannons also raise another the question: Had Al Gore been elected president in 2000-he did win the popular vote, after all-would he have invaded Iraq? Gore, the authors say, answered that he would have invaded Afghanistan, but not Iraq.
Not everyone will agree with the authors' arguments and views on the two presidencies, but father and son write with skill and the benefit of their White House experiences.
Lou Cannon covered Reagan for 36 years, first as California governor, then for the Washington Post during Reagan's presidency. Carl Cannon covered the Bush White House for the National Journal and is the coauthor of Boy Genius: Karl Rove, the Architect of George W. Bush's Remarkable Political Triumphs.
4•1•1
Reagan's Disciple: George W. Bush's Troubled Quest for a Presidential Legacy by Lou Cannon and Carl M. Cannon is published by Public Affairs. For more information, see publicaffairsbooks.com.
https://www.independent.com/2008/06/05/one-gipper/
'Marie Schoeff: Amplifying the Between'
Opera Santa Barbara's 'Semele'
Review | Royal Philharmonic Orchestra


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Shinya Yamanaka
Japanese stem cell researcher
Shinya Yamanaka [5] (born 4 September 1962 in Osaka) is a Japanese physician. He received the Nobel Prize in Physiology or Medicine for 2012 with John Gurdon.[6] He won the Wolf Prize in Medicine in 2011 with Rudolf Jaenisch;[7] and the Millennium Technology Prize in 2012 together with Linus Torvalds.
Shinya Yamanaka in 2013
(1962-09-04) 4 September 1962 (age 57)
Higashiōsaka Osaka, Japan
Kobe University
Osaka City University
Induced pluripotent stem cell
Robert Koch Prize (2008)
Albert Lasker Award (2009)
Wolf Prize (2011)
Fellow of the National Academy of Sciences [1] (2012)
Millennium Technology Prize (2012)
Nobel Prize in Physiology or Medicine (2012)
stem cell research [2][3][4]
Kyoto University, Gladstone Institute, University of California (UCSF)
He researches into adult stem cells.[2][3][4] He is director of Center for iPS Cell Research and Application and a professor at the Institute for Frontier Medical Sciences at Kyoto University. He is also a senior investigator at the UCSF-affiliated J. David Gladstone Institutes in San Francisco, California; and a professor of anatomy at University of California, San Francisco (UCSF). Yamanaka is also the current president of the International Society for Stem Cell Research (ISSCR).
What he didEdit
In development, embryonic stem cells can turn into any tissue. Fibroblasts in the skin are one type of cell. In 2006, Yamanaka and his team took adult mouse fibroblasts and turned them back into stem cells in tissue culture. The changed cells are known as 'induced pluripotent stem cells' (iPS cells).[2] iPS cells are like embryonic stem cells from a blastocyst (the embryo a few days after fertilization).
The procedure used transfection of some stem cell-associated genes into the adult fibroblasts. The transfected genes include the master transcriptional regulators. Transfection is typically done with viral vectors, such as retroviruses.
The team could show that the iPS cells were pluripotent (capable of generating all cell lineages of the body). Soon they grew mice which included iPS cells.[4] In 2007, he and his team generated iPS cells from human adult fibroblasts,[3] again the first group to do so. The main medical application will be replacement of faulty or damaged tissues in humans. This is not available at present. An independent assessment of this field is available.[8]
Wikimedia Commons has media related to Shinya Yamanaka.
↑ Nair P. 2012. Profile of Shinya Yamanaka. Proceedings of the National Academy of Sciences 109 (24): 9223–5. [1]
↑ 2.0 2.1 2.2 Takahashi K. & Yamanaka S. 2006. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126 (4): 663. [2]
↑ 3.0 3.1 3.2 Takahashi K.; Yamanaka S. et al 2007. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131 (5): 861–872. [3]
↑ 4.0 4.1 4.2 Okita K; Ichisaka T. & Yamanaka S. 2007. Generation of germline-competent induced pluripotent stem cells. Nature 448 (7151): 313–317. [4]
↑ Shinya Yamanaka (山中 伸弥, Yamanaka Shin'ya)
↑ The Nobel Prize in Physiology or Medicine – 2012
↑ Shinya Yamanaka: winner of Wolf Prize in Medicine – 2011. Wolf Foundation. [5]
↑ Müller L.U.W. George Q Daley G.Q. and David A Williams D.A. 2009. Upping the ante: recent advances in direct reprogramming. [6]
Retrieved from "https://simple.wikipedia.org/w/index.php?title=Shinya_Yamanaka&oldid=6333733"


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