text:
Autophagy Signaling and Cellular Pathways
Category: ENaC
ENaC
Programmed cell death 1 (PD-1) signal receptor blockade offers revolutionized the field of cancer therapy
Post author By foodexpowest
Programmed cell death 1 (PD-1) signal receptor blockade offers revolutionized the field of cancer therapy. Rabbit polyclonal to ZFAND2B and provide as an immune system regulator that settings inappropriate and intense immune responses such as for example autoimmune and extreme infectious immune reactions. It suppresses antigen receptor activation by PD-ligand 1 (PD-L1) and PD-L2, which participate in the co-stimulatory sign B7 family members. Although PD-L1 can be widely indicated on antigen-presenting cells (dendritic cells, arteries, myocardium, lung, and Bepridil hydrochloride placenta), PD-L2 exists on dendritic cells and is expressed in triggered macrophages. Binding of PD-1 to Bepridil hydrochloride PD-L1/2 relates to immunosuppression in the peripheral cells primarily. Indeed, PD-L1-released tumors develop in wild-type mice however, not in PD-1-knockout mice quickly, indicating that PD-1 takes on a central part in tumor cell immune get away mechanisms [7]. Predicated on the hypothesis that interruption of anti-PD-1/PD-L1 binding might activate T cells against tumor cells, PD-1 obstructing antibodies have already been created as immune system checkpoint inhibitors for tumor therapy [7] (Fig.?1). Open up in another windowpane Fig. 1 Background of designed cell loss of life-1 (PD-1) blockade tumor immunotherapy advancement The clinical effectiveness of nivolumab, an antibody against human being PD-1, was reported this year 2010 and 2012 [8 consequently, 9]. In 2014, nivolumab was authorized in Japan for the treating malignant melanoma for the very first time world-wide. PD-1/PD-L1 antibody-based therapy happens to be approved for the treating various malignancies (Fig.?1). Nevertheless, over fifty percent of patients usually do not react to this therapy [10]. Improving the response rate in patients with cancer relies on three different approaches: (1) elucidating the mechanisms underlying the lack of response to PD-1 antibody treatment, (2) developing novel predictive?markers, and (3) developing an effective combination therapy. These approaches and the status of current research are discussed in the subsequent sections. Biomarkers Killer T cells will Bepridil hydrochloride be the last effector immune system cells that assault tumor cells. Killer T cell activity can't be Bepridil hydrochloride expected by any solitary biomarker since it can be controlled by different elements (Fig.?2), including tumor- and immune-related elements, aswell while environmental elements such as for example enterobacteria and rate of metabolism. Open in a separate window Fig. 2 Regulation of killer T cell activity by various factors during PD-1 blockade therapy Biomarkers-tumor-related factors A nivolumab phase I clinical study revealed that PD-L1 expression in tumor cells may be an indicator of treatment efficacy [8]. Several clinical trials subsequently evaluated whether PD-L1 expression could be a predictive biomarker. However, a significant association between improved outcomes and PD-L1 expression was observed only in certain cancers [11]. According to clinical studies showing a positive association, the United States (US) Food and Drug Administration (FDA) approved pembrolizumab for the treatment of Bepridil hydrochloride PD-L1-positive non-small cell lung cancer (NSCLC), gastric or gastroesophageal junction cancer, and cervical cancer in 2015, 2017, and 2018, respectively. Furthermore, considering IMpassion130 study results, the FDA approved therapy with atezolizumab (a PD-L1 antibody) and chemotherapy (nab-paclitaxel) for PD-L1-positive and metastatic triple-negative breast cancer (TNBC) in March 2019 [12]. Two main mechanisms are hypothesized to be involved in PD-L1 expression in tumors: forced expression of PD-L1 due to translocations or mutations [13], and stimulation of intra-tumoral T cell-produced interferon, also known as adaptive resistance [14-16]. Because adaptive resistance is regulated by immune cell activity, PD-L1 expression show a correlation with PD-1 blockade therapy prognosis. However, insufficiency of tumor.
Data Availability StatementThe datasets generated or analyzed during the present study are available from the corresponding author on reasonable request
Data Availability StatementThe datasets generated or analyzed during the present study are available from the corresponding author on reasonable request. migration, whereas lower expression of miR-29 inhibited OS cell proliferation, PCNA expression and migration. In the present study, a dual-luciferase reporter system supporting phosphatase and tensin homolog (PTEN) was a target of miR-29 and its expression was inhibited by miR-29 mimic, but increased by miR-29 inhibitor. Overexpression of PTEN inhibited OS cell proliferation and migration and it could attenuate miR-29 promotion effect on OS progression. Overall, Macranthoidin B the full Gng11 total outcomes exposed that miR-29, like a tumor promoter, can be involved with Operating-system metastasis and development by focusing on PTEN, indicating that the miR-29/PTEN pathway can be a potential restorative target for the treating Operating-system. discovered that miR-29b influence on glioblastoma was suppressive (21). Ma mentioned that, miR-29 suppressed schwannoma cell proliferation and motility by regulating CDK6 (22). In cancer of the colon, miR-29 demonstrated inhibitory influence on cell invasion and migration by regulating MMP2 (23). Additionally, miR-29 suppressed lung tumor development by focusing on DNMT3A and DNMT3B (24). Nevertheless, part of miR-29 in Operating-system and its own system have already been reported rarely. It is popular that phosphatase and tensin homolog (PTEN) works as a tumor suppressor and PTEN manifestation was proved irregular in many malignancies (25). For example, PTEN functioned like a tumor inhibitor in regulating pancreatic tumor progression controlled by miR-32 (26). miR-21 modulated gastric tumor development via focusing on PTEN (27) and PTEN was also a focus on of miR-20b in modulating prostate tumor cell viability and migratory capability (28). However, the result of PTEN on Operating-system cell migration and proliferation and whether PTEN can be controlled by miR-29 in Operating-system have yet to become reported. Inside our research, miR-29 and PTEN in OS and its own potential mechanism in modulating OS cell proliferation and migration was investigated. Our outcomes might provide essential understanding in to the treatment and prognosis of OS. Materials and strategies Operating-system specimens We gathered conventional Operating-system and adjacent noncancerous cells from 60 individuals who underwent resection medical procedures in the First Associated Medical center of Zhengzhou College or university (Zhengzhou, China) between Feb 2010 and August 2016. non-e of OS patients had received radiotherapy or chemotherapy before surgery and the tissues were diagnosed as OS by pathologists. All tissue specimens were placed into liquid nitrogen immediately and stored at ?80C in a refrigerator for use in subsequent experiments. The Ethics Committee of Zhengzhou University approved this study and the patients signed informed consent prior to surgery. Cell lines and cell culture The purchased OS cell lines (MG-63, U2OS, 143B, Saos-2) were cultured in RPMI-1640 medium at 37C and the medium contained 20% FBS and penicillin (100 U/ml) and streptomycin (100 g/ml). hFOB1.19 (normal human osteoblast) cells were cultured in DMEM supplemented with 10% FBS and G418 (0.03 mg/ml) at 34C with 5% CO2. OS cell lines (MG-63, U2OS, 143B, Saos-2) and hFOB1.19 (normal human osteoblast) cells were obtained from ATCC (Manassas, VA, USA). Cell transfection miR-29 mimic or inhibitor provided by Suzhou GenePharma Co., Ltd. (Suzhou, China) was transfected into MG-63 cells to facilitate or inhibit miR-29 expression and control mimic were used as control (con). We added MG-63 cells into 24-well plates containing medium and we performed transfection using Lipofectamine 3000 reagent (Invitrogen; Thermo Fisher Scientific, Inc., Waltham, MA, USA) for 48 h. PTEN vector and con vector were synthesized by GenePharma Co., Ltd. and they were used to enforce PTEN expression and acted as a control separately. RNA extraction and reverse transcription-quantitative polymerase chain reaction (RT-qPCR) Total RNA and microRNA were extracted from OS tissues and cells using TRIzol reagent (Invitrogen; Thermo Fisher Scientific, Inc.) according to the Macranthoidin B manufacturer's protocol. Complementary DNA was synthesized using Macranthoidin B PrimeScript RT reagent kit and RT-qPCR was performed using SYBR Premix Ex Taq (both from Takara Biotechnology Co., Ltd., Dalian, China) with the Stratagene Mx3000P real-time PCR system (Agilent Technologies, Inc., Santa Clara, CA, USA). The primer sequences used were: miR-29-F: TGCCAGGAGCTGGTGATTTCCT, miR-29-R: ACGGGCGTACAGAGGATCCCC. PTEN-F: GTGCAG ATAATGACAAG, PTEN-R: GATTTGACGGCTCCTCT. proliferating cell nuclear antigen (PCNA)-F: GGTGTTG GAGGCACTCAAGG, PCNA-R: CAGGGTGAGCTGCACC AAAG. U6-F: CTCGCTTCGGCAGCAC, U6-R: ACGCTTC ACGAATTTGC. -actin-F: GA TCATTGCTCCTCCTGAGC; -actin-R: ACTCCTGCTTGCTGATCCAC. -actin and U6 were used while internal settings. Relative manifestation of miR-29, PCNA and PTEN was calculated by the two 2?Cq technique (29). Traditional western blot.
Antibiotics will always be considered as one of the most relevant discoveries from the twentieth hundred years
Antibiotics will always be considered as one of the most relevant discoveries from the twentieth hundred years. from the antibiotic and limit its strength. Open in another window Shape 2 Toon representation of different systems of antibiotic level of resistance. Antibiotics mainly because white and reddish colored supplements, target protein in green. A thorough set of AMR bacterias was recently released by the Globe Health Corporation (WHO) on the actual fact sheet of 27 Feb 2017. Pathogens are categorized as essential, high, and moderate, which classification is dependant on mortality, degree of level of resistance, and treatability. The problem is highly essential in infections caused by the Gram-negative ESKAPE: gene produces mutants which are more susceptible to different classes of antibiotic (e.g., chloramphenicol, fluoroquinolones, tetracyclines, or beta-lactams) [30]. Cross-resistance to unrelated antibiotic classes: Cross-resistance comprises Tin(IV) mesoporphyrin IX dichloride evolutionary events from the version of antibiotics, or any additional antimicrobial medication, which reduces the organisms level of sensitivity to multiple medicines. This is credited, generally, to a higher exposure to confirmed antibiotic. Wide range level of resistance can be seen in bacterias in which energetic efflux features synergistically with additional mechanisms of level of resistance, for example, in any risk of strain that expresses both efflux and beta-lactamases pushes, and which is insensitive to beta-lactams [31] also. Thus, it's been discovered that the mix of these two systems of level of resistance (efflux pushes and beta-lactamases) escalates the level of level of resistance to quinolones [32]. Mutations could be preferred in bacterias overexpressing efflux pushes. Certainly, for the reason that condition, antibiotic focuses on become subjected to subinhibitory concentrations and may mutate to inhibit the result of antibiotics [33], conferring high-level resistance eventually. The energetic efflux of antibiotics was referred to for the very first time 30 years back. At that right time, the current presence of plasmid-encoded protein in a position to extrude tetracycline and confer level of resistance to the antibiotic in [34] was researched by McMurry and co-workers. Since then, many classes of efflux pushes, Tin(IV) mesoporphyrin IX dichloride both in Gram-negative and Gram-positive pathogens, have already been characterized. Today, efflux pushes can be viewed as as potential antibacterial focuses on, because of the part in antibiotic level of resistance, and the advancement of inhibitors could enhance the restorative arsenal against resistant pathogens. Rabbit Polyclonal to Chk2 (phospho-Thr387) In the framework of antibiotic mixture therapy, efflux pushes will vary from other systems of level of resistance (such as for example beta-lactamases) that focus on a specific category of antibiotics. Certainly, an individual efflux pump can extrude an array of different groups of antibiotics and, for this good reason, their inhibition shall raise the bacterial susceptibility and their combination can work with several antimicrobials. There are many methods for inhibiting efflux pushes: (i) interfering with efflux gene manifestation, (ii) adding practical groups towards the medication substrate to hamper reputation, (iii) interfering using the set up of route Tin(IV) mesoporphyrin IX dichloride protein, (iv) developing small-molecules as substrate analogues in a position to stop the efflux pump activity, or (v) in a position to disjoin the power transfer mechanism from the pump, or (vi) in a position to obstruct the route [35,36]. Consequently, you'll be able to corroborate that inhibition of efflux might trigger a number of results: (i) raising the activity from the antibacterial medicines at the mercy of efflux, (ii) keeping the focus from the medication at the restorative dosage, and Tin(IV) mesoporphyrin IX dichloride (iii) shortening the length of treatment by reducing multi-drug tolerance [37,38]. Probably the most broadly exploited strategy may be the development of efflux pump inhibitors (EPIs), which are intended for combination therapy with specific antibiotics. EPIs are small molecules that are able to bind efflux pumps and block their extrusion activity. EPIs, usually, do not have intrinsic antibacterial activity. For this reason, these compounds are further tested for synergy with different concentrations of antibiotics against a single.
Supplementary MaterialsAdditional file 1: Appearance of HPV-16 E6/E7 for TC-1 CICs and non-CICs
Supplementary MaterialsSupporting Information ADVS-7-1901785-s001
The rapidly growing field of tissue engineering along with stem cell therapy has a promising future in pediatric urological conditions
Type 1 diabetes (T1D) affects millions of people worldwide and is the prevalent form of all pediatric diabetes diagnoses
Dihydrotestosterone Receptors
DMTases
DNA Ligase
DNA Ligases
DNA Topoisomerase
DNMTs
Dual-Specificity Phosphatase
Ecto-ATPase
EDG Receptors
Elk3
Encephalitogenic Myelin Oligodendrocyte Glycoprotein
Encephalitogenic Myelin Proteolipid Fragment
© 2021	Autophagy Signaling and Cellular Pathways


text:
Chini Ka Rauza
Situated at a distance of 1 km north of Itmad-Ud-Daulah's tomb, Chini ka Rauza is the tomb of Allama Afzal Khan Mullah of Shiraz, a scholar and poet who was the Prime Minister of the Mughal Emperor Shah Jahan. Built in 1635 AD, the tomb has a rectangular shape and is made up of brown colored stones.
Nowhere is history more bountiful than in the Agra. The architecture-minded legacy of the Mughal era long saw fit to protect its extraordinary system of structures dedicated to the living and the dead, in a series of monuments and tombs and which are now watched by the world. Chini ka Rauza is one among them, the ultimate meeting of the old and the new, a testament to honor and patronage, and awesome architectural finesse jutting out of the monument's very walls. Situated at a distance of 1 km north of Itmad-Ud-Daulah's tomb, Chini ka Rauza is the tomb of Allama Afzal Khan Mullah of Shiraz, a scholar and poet who was the Prime Minister of the Mughal Emperor Shah Jahan. Built in 1635 AD, the tomb has a rectangular shape and is made up of brown colored stones. The tiles are in blue, yellow and green colors and the ceilings have decorative inscriptions. The central chamber is octagonal and has eight arched recesses. Four, square chambers emerge from it and are connected to the side halls and outer porches. You can enter the Chini ka Rauza from the central arch where there are inscriptions marked out with blue colored tiles.

redpajama_set_name: RedPajamaCommonCrawl


>>>> scale their output by a factor of 8x to dsputil properly?
>> to get it done ASAP).
>>> to make more sense ..
>> is concerned, appears to be scaled by a factor of 1/8x.
>> is by the rest of FFmpeg's machinery?
>> scale it back by a factor of 8x" -- that's fine too.
>> and the one from AMD.
codecs like h264, jpeg2k and dnxhd.


Personality: Kind to everyone, is willing to stand up for whoever is in trouble. They are VERY determined.
Hobbies: Making friends and making puns.
Oh dang this got lots of app's in the timelaps...Welp, time for REVIVAL BUMP!
(03-22-2016 12:20 PM)Dorkie Wrote: basic thingy.
Ref:Kindness is a good thing!
Presonallity: Kind to everyone who meets him and a cooking expert, this kid travels the underground with a warm heart and cooks to whoever needs it. It´s not afraid to step up to save someone, but it´s reckless at some times.
Likes: High-Quality Frying Pans, Fresh Cooking Ingredients.


text:
North Carolina misses the municipal broadband benefits Kansas City gets with Google
by Samantha Bookman |
The excitement around Google's (Nasdaq: GOOG) selection of Kansas City, Kansas as the first city in which the search engine giant will build out a 100 Gbps open access network has perhaps overshadowed the latest dust-up in North Carolina over legislation that would prevent cities in that state from doing anything similar to what Kansas City is about to do.
It's the endgame in a years-long series of legislative moves to disallow municipal-owned broadband networks from being established in North Carolina cities. Past bills did not make it through the state legislature, but HR. 129, aka the "Level Playing Field/Local Government Competition" bill introduced by Republican Rep. Marilyn Avila was approved 81-37 by the state's House of Representatives in late March and is currently being debated at the state Senate level.
Incumbent cable operator Time Warner Cable (NYSE: TWC) and telcos CenturyLink (NYSE: CTL) and AT&T (NYSE: T) openly support the measure, at the heart of which is a claim that municipally funded and managed broadband networks unfairly compete against them by doing things like offering broadband services at rates below those of incumbent providers.
North Carolina isn't the only state where municipal broadband is on the blocks--14 states have already banned or limited municipal broadband efforts, according to Wayne Caswell, a technology consultant and community broadband advocate. But it's a glaring example of the lengths to which incumbent providers will go to prevent competition from nibbling away at their profit margins. At a time when bringing high-speed Internet service to underserved areas across the U.S. is supposedly a high priority, legislatures are bringing down the hammer on innovative ways to get those networks built out.
Municipal broadband advocate Craig Settles was one of the most vocal critics of the North Carolina bills in recent weeks, pointing out in an interview with FierceTelecom that communities are able to build out networks offering higher speeds than the big telcos or MSOs can provide.
"(In the United States there are) 55 community owned fiber networks. Eighty to 90 cable networks are owned by communities," he said. "These networks are delivering the national broadband plan. They are exceeding the requirements, the capability of this delivery... and this is why we are having all these legislative issues. It points to the hypocrisy of these incumbents and their supposed adherence to free market conditions."
If there's a sticking point to municipal networks, it's the up-front costs involved in building them. Fiber is expensive to install--enough so that taxpayers may balk at the amount of money it may take to roll out high-speed services. And the economic pressure on communities today isn't helping. The city of Salisbury, N.C., last week was forced to lay off four employees, including the marketing director at Fibrant, the city's high-speed Internet service launched late in 2010, in a move to trim the overall budget, the Salisbury Post reported last week.
However, that isn't a compelling reason to limit or ban municipal broadband, nor should the specter of competition cause lawmakers to issue blanket bans, either. "Cities have always been in the infrastructure business, building streets, bridges, airports, water works, and electric power systems," Caswell writes in a whitepaper, Big Broadband: Public Infrastructure or Private Monopolies. Funds for such infrastructure are raised through taxes and bonds, and payback is long-term via access fees. He doesn't see municipal broadband as being any different.
That's a key point in the issue of whether to allow cities to own and operate broadband networks. Fiber optic technology may be (somewhat) new, but installing and maintaining public utilities and infrastructure isn't new or unfamiliar to American cities.
Municipal broadband doesn't have to prove itself as a viable option for high-speed networking, any more than incumbent telcos and cablecos have to prove themselves. It's managed by, paid for by, and ultimately owned by the residents and taxpayers of the community it serves. And while failure in the face of competition from private providers or due to a shaky economic climate is a possibility, the advantages of a community-owned and managed high speed network--lower subscription rates, higher broadband speeds, and a resultant economic boost for local businesses-- outweigh the disadvantages.--Sam
Samantha Bookman
https://twitter.com/FierceSamantha


Golden Eagles in Britain are largely sedentary and adults that have acquired a territory are unlikely to move more than a few kilometres for the remainder of their lives. Non-breeding juveniles and immature eagles, by contrast, disperse over 150km. It is known that young birds wander furthest in their first two years before returning toward their natal areas in search of vacant territories. Such natal philopatry was probably inhibiting the potential for natural recolonisation of Ireland from a rather unproductive population of eagles in Southwest Scotland (Wernham 2002).
Since the Golden Eagles have been released in Golden there have been confirmed sightings and satellite tagging data showing these birds dispersing throughout the Northwest, from a line from Antrim to Galway. There have been Golden Eagle records from County Clare and County Kerry, probably of released Birds. And there has been a record of a Glenveagh bird on Rathlin Island also. Two records of wing tagged Golden Eagles on Mull, probably relate to Irish Eagles.
Females seem to disperse further than males as immatures. In Donegal, one of the breeding adult females has moved over 30 km between two breeding attempts, pairing with a new mate in a new territory, which is very unusual.


text:
Q: ngDialog templateUrl not working when code is minifed I am using ngDialog in a project, and when the code is not minified, in development, this piece of code works just fine:
ngDialog.open({
 template: '/static/scripts/modules/vote/Dialog.html',
            controller: 'DialogCtrl',
            scope: scope
 });

But, when the code is minified, I get this error:
GET http://pageUrl/static/scripts/modules/vote/Dialog.html 404 (Not Found)

It seems that the app can't access the html file, but why then does it work when code is not minified?

A: try with this
ngDialog
                .open({
                    template : 'comment',
                    className : 'ngdialog-theme-flat ngdialog-theme-custom',
                    scope : $scope
                });

redpajama_set_name: RedPajamaStackExchange


text:
(13777) Cielobuio ist ein Asteroid des Hauptgürtels, der am 20. Oktober 1998 von den italienischen Astronomen Marco Cavagna und Augusto Testa am Osservatorio Astronomico Sormano (IAU-Code 587) in den lombardischen Voralpen etwa 40 Kilometer nördlich von Mailand nahe der Ortschaft Sormano in der Provinz Como entdeckt wurde.

Der Asteroid wurde am 11. November 2000 nach der italienischen Gesellschaft gegen Lichtverschmutzung CieloBuio benannt, die eine grundlegende Rolle bei der Durchsetzung eines regionalen Gesetzes in der Lombardei spielte, das als eines der fortschrittlichsten weltweit gilt.

Der Himmelskörper ist Mitglied der Koronis-Familie, einer Gruppe von Asteroiden, die nach (158) Koronis benannt ist.

Siehe auch
 Liste der Asteroiden

Einzelnachweise

Weblinks
 Asteroid Cielobuio: Discovery Circumstances gemäß dem Minor Planet Center der Internationalen Astronomischen Union bei dem Harvard-Smithsonian Center for Astrophysics, Cambridge, USA

 cielobuio.org (italienisch)

Hauptgürtelasteroid unter 50 km Durchmesser

redpajama_set_name: RedPajamaWikipedia


A small (less than 3 inches along its largest dimension) video game console device, based on the Raspberry Pi Zero, capable of emulating classic video games. Example systems include the original Nintendo Entertainment System (NES), Super Nintendo (SNES), Sega Genesis / Mega Drive, arcade games, etc.
Because old video games are awesome, and using an emulator on your computer isn't nearly as fun. In their time, these games were often enjoyed in people's living rooms. This project helps revive a piece of that nostalgia in a fun, sharable way that anyone (not just tech enthusiasts) can appreciate.
Excluding the TV (which you probably already have), it ends up costing around $70 USD when you include everything: the device itself, cables, power, an SD card and 2 (yes, two) gamepads/controllers. You could also skip some things and build it for a bit less, or add more features for a bit more.
Most of it can be built using off-the-shelf parts from places like Amazon.com many online stores (see note at bottom). For the enclosure, you'll need access to a 3D printer (or an online 3D printing service), a few standard tools, a short M3 screw (~ 8mm should be enough), and a soldering iron (optional if you want an extra power LED light).
As a fan of old video games, I'd been wanting to put together an emulator box/console for my home. My wife asked (ok, begged) me to finally make one, but she didn't want to deal with a mess of wires or exposed circuit boards whenever we wanted to play it. It also needed to be cheap and easy enough for other family members to use.
In the past, I put together various projects around the home using Raspberry Pis, so based on what I saw other people doing online, I figured I could easily use a Raspberry Pi Zero to accomplish the task. Seeing that the brains and software for the device would easily be fulfilled by a Pi Zero and some freely available software, I turned my attention to the case.
My other RasPi-based projects were perfectly content being housed in generic Raspberry Pi enclosures (or sometimes no enclosure at all) because they were out-of-view, so aesthetics didn't really matter. But this project was different.
For something that would visibly occupy space in the living room, the retro gaming console demanded more attention.
I found some impressive builds like this one that look just like a classic Nintendo (complete with tiny "cartridges" for switching games), and others with varying levels of detail, but I wasn't interested in going down that road. I was looking for something simple and attractive; not so much a replica or an art piece.
We need an adapter for plugging in standard USB gamepads to the Pi Zero's USB OTG port.
For multiple gamepads, we either need a USB hub or an adapter with a built-in hub.
The USB port is on the same side of the device as the power and HDMI (ideally the USB ports are exposed on the front, with power and HDMI in back).
Many of the generic Pi cases expose the GPIO pins (and other board features), which are necessary for some projects, but not this one.
Surely we could do better without spending a lot more time or money on this thing… right?
I could add a Bluetooth module and avoid any exposed USB/gamepad ports, but wireless gamepads are more expensive, not to mention more of a hassle to keep charged; I'm sticking with USB for now.
After researching and testing several gamepads on my own, the best value for the money seems to be the Buffalo Classic USB Gamepad. You may prefer something different or more expensive, but I haven't had any problem with these.
No WiFi is necessary - the idea is to load some games onto an SD card, keep the SD card in the device, and avoid any more complexity.
The SD card slot probably doesn't need to be accessible for everyday use.
A power switch/button would be nice to avoid having to plug/unplug from the wall.
The Pi Zero is really small - almost too small. Once cables are plugged into it, it seems more manageable and "friendly" in a slightly larger form-factor.
The case should be easy to 3D print.
Use a UL listed power supply (so we don't burn down the house).
Keep it relatively simple to build.
* If you don't live in the UK, you'll likely have to pay extra for shipping on the Raspberry Pi Zero. Most of the other components can be shipped for free, and if you purchase the Pi Zero in a kit (with some of the other required components), you may be able to offset the shipping price.
The MakerSpot Stackable USB Hub gives us 3 USB ports on the side opposite the power and HDMI ports, so that made it a great choice for this project (we wanted the gamepad ports exposed on the front and everything else in back).
With the added height of the USB Hub, the USB ports would either be exposed down close to the floor of the unit, or higher up. It looked better with the ports higher up.
The cover for the case is located on the underside and recessed so as to be completely hidden when the device is sitting on a flat surface.
The mini-HDMI to HDMI adapter is incorporated into the case itself to make things more tidy. It's not the most elegant solution ever, but it's easy, cheap, and makes for a friendlier experience for people who may have never dealt with mini-HDMI. This effectively gives the device dimensions that are closer to square (rather than the Pi Zero's oblong dimensions).
While the Raspberry Pi Zero stays reasonably cool during normal operation (aided in part by the CPU heatsink), vents are added to the top of the enclosure to provide some airflow for better heat dissipation.
The Micro-USB port for power will require less-frequent access than the other ports on the device. To avoid yet another adapter or extension within the enclosure, I opted to make that port accessible via a small recessed space on the back.
By orienting the PCBs with the USB ports exposed near the top of the unit, the ports (not just USB, but also HDMI) are "upside-down" compared to what has become common orientation. As far as I understand, that's not strictly a standard, and most people won't notice the difference anyway.
The microSD card slot is accessible through a small slit in the side of the enclosure, but it's intended to be used only rarely (e.g., upgrading the system). A pair of fine-point tweezers is necessary for extraction of the card.
Using metal machine screws or a tap, create some threads in the mounting and bottom cover screw holes. The holes for mounting the PCB are M2.5, and the hole for the bottom cover is M3. I just use a metal screw of the appropriate size, drive it in (until it bottoms out for the PCB mounting holes, and just enough depth for your cover screw) and back it out. I use a nylon screw for the cover, but if you're going to use a metal screw for securing the cover, there's no need to create threads first. Just don't use nylon screws in holes that haven't been threaded with a metal screw/tap first or the plastic will destroy the screw threads. The stackable USB hub comes with its own set of nylon standoffs and screws, so we're going to use those later.
(optional) If you want an extra LED status light for indicating when the device is on (the Pi Zero's built-in lights are not very bright through the enclosure), you can solder an LED to the Pi Zero board. In my case, I found a spare 5mm green LED, soldered a 100 ohm resistor to one of the leads (along with a short bit of solid core wire), applied some heat shrink tubing for insulation, and finally soldered the two wires to the +5v and ground pins of the Raspberry Pi Zero.
Place the stackable USB hub (not attached to the Pi Zero yet!) into the enclosure ensuring that the three USB ports line up with the spaces in the enclosure. Screw the four M2.5 nylon standoffs (that come with the stackable USB hub) through the hub's mounting holes and into the holes of the enclosure. For added strength, add a drop or two of cyanoacrylate to the holes before tightening the standoffs. Don't over-tighten, but make sure the USB hub rests flush with the top of the holes of the enclosure.
Carefully place the Raspberry Pi Zero on top of the stackable USB hub, ensuring that the hub's pogo pins make contact with the correct pads on the Pi Zero. Use the 4 nylon screws (provided with the hub) to secure the Pi Zero to the USB hub standoffs.
Insert the mini-HDMI to HDMI adapter through the hole in the back of the enclosure and into the mini-HDMI port on the Pi Zero.
Using a hot glue gun, apply some hot glue around the area where the HDMI adapter meets the inside of the enclosure. This will prevent the adapter from being inadvertently pulled out of the case. It's also probably a good idea to add a few dabs of hot glue between the corners of the PCB(s) and the interior of the case. We're not using metal screws, so this will help keep the PCBs affixed to the case, especially when pressure is applied while attaching/removing controllers.
Remove the adhesive backing from the heatsink and attach it to the Raspberry Pi Zero's CPU.
(if wiring a power status LED) Route the LED and wiring to a location within the case to provide good visibility. For many plastics, the enclosure will be translucent enough (and the LED bright enough) to allow you to place it just about anywhere, as long as it's facing outward. I usually place the LED near the vent holes on the top of the enclosure so it can be seen even through opaque materials (by shining up through the vents). You could add a small bit of hot glue to keep the LED in place, or skip the glue if the wires are stiff enough to keep things from moving around. Just make sure the wires and LED don't get in the way of the bottom cover.
Screw on the bottom cover with a short M3 screw.
Use a computer to prepare the microSD card, loading the desired software, configuration, and games (info below).
Insert the microSD card through the slot in the case, making sure it's oriented correctly for the Raspberry Pi Zero. You'll probably need a pair of tweezers or other sharp object to help push it fully into the Pi Zero microSD card slot (and for removal).
There are several options for running emulation software on a Raspberry Pi. For tinkerers and tech-oriented people who want a lot of control and flexibility over the system, RetroPie is a great option.
For this build, however, I was interested in something that favors simplicity over customization. For that, I chose Recalbox. Even with Recalbox, there are quite a few configuration options that affect the appearance and behavior of the experience, so I took a bit of time to create a configuration that turns off some unnecessary features and keeps things straightforward and easy-to-use.
Specifically, the Raspberry Pi Zero has no built-in Ethernet or Wi-Fi (and we don't need networking), so we turn off Recalbox's HTTP manager, SSH, and REST API. And since we're using this exclusively for emulation, we disable Kodi. Finally, to keep things simple, we disable extra emulator menus and advanced settings that would normally be shown in the UI.
For games (commonly referred to as ROMs), unfortunately you're on your own. I don't endorse the downloading or use of ROMs for which you don't have a legal license. There are quite a few websites that offer free, fully-legal homebrew video game ROMs that you can download and play on this system. If you're looking for more mainstream classic titles, you may or may not have luck searching for them elsewhere. There's my Glomar response for the day.
I'm fairly happy with the final result, and more importantly, my wife and kids (and some extended family) enjoy using the emulator device - and they don't need my help figuring out how to use it. It just works.
Implement a switch- or button-activated power off function to cleanly shut down and power off the unit. This would help avoid the eventual possibility of corrupting data if the filesystem isn't in a consistent state when power is cut off. In practice, I think the risk of corruption is quite low, but it's still a concern.
As mentioned, the ports should probably be flipped around the other way.
Rather than relying on plastic screws and hot glue to keep the PCB attached to the case, use metal screws and nuts to keep things more securely in place. Alternatively, build the necessary standoffs and anchors into the enclosure itself for a press-fit hold on the PCB.
Incorporate the power status light (and switch) into the case design.
Expose 2 or 4 USB ports instead of 3. Not sure why exactly - 3 just seems a little… odd?
Find a better way to expose the Micro-USB power port and HDMI port without resorting to the embedded adapter or recessed cavity in the design.
Remove the microSD slot on the side, allowing for emergency access some other way.
… of course, if we're going to over-engineer this thing beyond a certain point, we might as well put together a custom board, create a plastic injection molded case, get the hardware certified, etc. and sell the thing. And of course, some people are doing just that.
But that would turn the project into a business enterprise, and it certainly wouldn't be as enjoyable as building it myself.
Copyright © 2017 Lumination Labs, Inc. All rights reserved.


text:
Engine and Technical Discussion
2014 Mercedes CLA Six-speed Manual Transmission
The six-speed manual transmission: Comfortable manual gearshifts
The new six-speed manual transmission was developed in parallel with 7G-DCT. It is extremely compact and shares a number of common parts.
The three-shaft transmission is also very compact (length 345 mm) and light (dry weight 46 kg) and incorporates a number of special features for particularly pleasant gearshifting. An integrated magnet on the gearshift shaft is detected by a Hall sensor. The idle position is identified in this way, making the start/stop function possible. The signal for reverse gear activates the reversing lights.
The large spread of 6.7 allows a reduction in engine speed while at the same time ensuring that sufficient tractive power is available when moving off with a fully laden Mercedes-Benz A-Class and trailer up to a gross weight of 3.4 tonnes. The clutch is operated hydraulically and the gears are actuated via cables.
The overhead camshaft with third and fourth gears and the reverse gear do not run in the oil bath. This reduces drag torque, thus facilitating gear shifting at low temperatures in particular. The three-cone synchronization of the first two gears serves the same purpose, while the following gears are provided with two-cone synchronization. The weight-optimized cast aluminum shift forks are installed on anti-friction bearings on the shift rods, in order to reduce the shift forces.
AMG4Matic
The cable shifters will make for lighter shifts but not as tight and reactive as linkages. Seems like most front wheel drive cars use cables.
MaximilianJürgen
I noticed that too with new cars. Linkages give the driver a more direct feel when it comes to front wheel drive vehicles but linkages are not as durable as we think they are. Most of the vehicles in the past that use linkages was due to get new ones or have issue later. And one thing im sure a lot can appreciate is the little effort and forced needed to shift with the cable types.
BODHI85
Whats the Mercedes stick shift thread size? I plan to switch it out the knob.
Too bad we aren't getting a manual transmission in north america....
Tonyride
Black CLA250 - Premium, Multimedia, Sport, Panorama roof, Bi-Xenon, Window Tinting (50%/35% Front/Rear), Carlsson C-Tronic.
Bridgestone Blizzak LM-60 RFT (Run Flats) mounted on 18x8 Anzio Turn Bright Silver wheels with TPMS sensors for winter driving.
Perhaps if BMW sells enough 2-series cars with manual transmissions, then maybe Mercedes will reconsider and offer a manual transmission CLA in the USA. One can only hope!
A 6 speed manual Mercedes in North America?
Keep on dreaming the dream.
Reactions: MERC
Wimbledon said:
I think BMW already has plans for this on the 2-series, they have always been the brand that stayed driver focus where ever appropriate, if they don't offer a manual in the 2series it will be a big change for BMW.
I have seen a 6 speed transmission on a C class before. So why can't it be available for the CLA
I believe that was in the lower trim models of the C class and they were so rare. But with the way Mercedes is going they want to just keep it straight automatic from now on.
Bmw on the other hand will be offering the 6 speed transmission, well that is sort of their thing. I don't think it would be enough to steal the win from the segment but some might have that as a priority in smaller numbers.
Mercedes is just as sporty but they are a different breed trying to accomplish things with the DCT. I believe even the SLR didn't come with a 6 speed transmission. Guess it's not a common focus for them.
Did you hear the new Porsche 911 GT3 is dual clutch PDK only?!
IT'S A GT3 THOUGH!
Manuals are dying out.
New Porsche 991 GT3. First Drive. - CHRIS HARRIS ON CARS - YouTube yup
I would pick this up in an instant. Faq is wrong Mercedes?
Mercedes doesn't cater to manual drivers in north america anymore.
brianch said:
Only nine percent of drivers in US drive a stick. That is why they are disappearing. Been driving a manual most of my life but they are getting harder to find and also impact on resale value.
RSM said:
My first 4 vehicles were manual. It wasn't until I got married that I started buying autos. Now I get my manual fix when I go to Europe and rent manual transmission cars.
Tonyride Jan 25, 2014


text:
Deborah Eisenberg's fifth collection of short stories, Your Duck Is My Duck, will be published in September. She is also the author of a play, Pastorale.
(August 2018)
The Dry Heart
by Natalia Ginzburg, translated from the Italian by Frances Frenaye
Happiness, as Such
by Natalia Ginzburg, translated from the Italian by Minna Zallman Proctor
Natalia Ginzburg's work is so consistently surprising that reading it is something like being confronted with a brilliant child, innocent in the sense of being uncorrupted by habit, instruction, or propriety.
After the Gold Rush
Dawson City: Frozen Time
a documentary film written and directed by Bill Morrison
Dawson City: Frozen Time is nominally a documentary—it is a documentary—but describing it as a documentary is something like describing Ulysses as a travel guide to Dublin. The film is transfixing, an utterly singular compound of the bizarre, the richly informative, the thrilling, the horrifying, the goofy, the tragic, and the flat-out gorgeous.
Robert B. Silvers (1929–2017)
From its first issue in 1963, Robert Silvers was either co-editor with Barbara Epstein or, after her death in 2006, editor of The New York Review. Bob worked almost to the very end of his life, which would be no surprise to those who knew him well, including those who have written these brief memoirs.
A Blinding Need for Each Other
The Door
by Magda Szabó, translated from the Hungarian by Len Rix, with an introduction by Ali Smith
Magda Szabó's The Door is unmistakably a work of fiction, with fiction's allusive and ambiguous purposes and effects, but it is narrated in the first person by a writer and composed—perhaps almost entirely—of frankly autobiographical recollections.
A Wonderful Novel and an Impossible Challenge
The End of Days
by Jenny Erpenbeck, translated from the German by Susan Bernofsky
Jenny Erpenbeck's wonderful The End of Days opens with the death of an infant in 1902 near the eastern border of the Austro-Hungarian Empire and ends with the death, nine decades later, of a woman in an old people's home in Berlin, but the book, bracketed as it is by death, is so alive that one closes it gently.
Cross Off and Move On
Adela, Bernice, and Charna, the youngest—all gone for a long time now, blurred into a flock sailing through memory, their long, thin legs streaming out beneath the fluffy domes of their mangy fur coats, their great beaky noses pointing the way.
"Who is that?" Adam asked, pointing at a boy on a swing set. Adam was helping, pasting photographs into an album at the kitchen table. His mother, rolling out a piecrust at the counter, paused to look.
"That's Uncle Tommy," she said. "Don't you get flour on that." Next there were some grown-ups sitting on Gramma and Grampa's couch. Next a lot of people in front of extra-tall corn, kids in front. "Is this Aunt Rosalie?" "That's Rosalie all right—look at the hair."
In the Fine Print of Experience
All the books of the twentieth-century British novelist Henry Green are relatively short and unobtrusively but highly condensed. And anyone who has read several of them will almost certainly have observed not only how different they are from one another, and in how many ways, but also that one of their shared features is how stunningly different they are from anybody else's.


This wedding was a BLAST. Rachel and Mike were married on the lake on a perfectly cloudy day. I was giddy.
Her flowers were some of my favorites EVER.
Sweet Rachel was laughing all. day. long. It was wonderful. She just overflows with joy!
Okay, okay, I know I posted so many photos of her flowers. I was basically stalking her flowers all day. Can't get enough!
One of the very best days! I hope I did them justice. These two love life and love fun. What an honor it was to capture their joy!


text:
Q: When I'm deploying ios app to simulator, it is not showing me complete screen When I'm deploying ios app to simulator, it is not showing me complete screen.
I've already configure proper launch images.
simulator size (3.5")

A: What's happening is that because your monitor is not a retina display and the device your simulating is it takes up more space on your monitor (notice the scroll bars).
You can scale the simulator so you can see everything at once without scrolling by clicking on Window > Scale > The percentage you want.
Aside from the scrolling issue, if the actual content doesn't display then you will need to either place it in a scroll view or set up your constraints to handle the different screen sizes.


text:
You selected Support for who?Support for the armed forces community Support for who?Support for students Help with what?Help with a wide range of issues Help with what?Help with learning Support for who?Support for asylum seekers and refugees Clear all
Change Step Wales
https://www.swansea.gov.uk/changestepwales
Support for veterans, their families and carers in Wales.
GROW Cymru (Growing Real Opportunities for Women)
https://www.swansea.gov.uk/growcymru
Provide training, support, mentoring and guidance to women of all backgrounds and ages across South Wales.
Royal British Legion
https://www.swansea.gov.uk/royalbritishlegion
Provide lifelong support to serving and ex-serving personnel and their families.
SSAFA
https://www.swansea.gov.uk/SSAFA
Provide lifelong support to those who are serving or have served in the British Army, Royal Navy, Royal Marines or the Royal Air Force, and to their families.
Swansea Council for Voluntary Service
https://www.swansea.gov.uk/SCVS
Swansea Council for Voluntary Service support, develop and represent voluntary organisations, volunteers and communities across Swansea
https://www.swansea.gov.uk/unityindiversity
Provide food, support and learning opportunities to asylum seekers and refugees in the Swansea area.
Veterans Gateway
https://www.swansea.gov.uk/veteransgateway
Support ex-forces members with healthcare and housing issues, and also give advice about employability, finances, personal relationships and more.
Welsh Refugee Council
https://www.swansea.gov.uk/WelshrefugeeCouncil
Support for refugee and asylum seekers.


If you are hunting for a legitimate, affordable "green" carpet cleaning company in Warminster, PA, Oxigreen is here for you! Oxigreen is known as a 100 % green carpet cleaning company, also available to do carpet stretching and expert carpet repair.
We are living in a significant time in our history and at OxiGreen in Warminster, PA, we feel very strongly about protecting the environment. We are making green cleaning one of our company's top priorities.
At OxiGreen in Warminster, PA, we provide a detergent-less carpet cleaning and we are extremely proud of that. Our carpet cleaning process can be achieved without resorting to using chemical cleaning agents like some other carpet companies. In fact, our cleaners are so nontoxic you could ingest them ... not that you would. Now, that is what we call safe, natural and environmentally-friendly!
Combined with OxiGreen's pledge to "green" carpet cleaning is our very powerful and remarkably environment friendly truck-mounted carpet cleaning machinery. The process releases heated water deeper into your carpets, releasing the dust mites, allergens and other allergy causing substances that the majority of vacuums and carpet cleaners never even touch.
Using this kind of equipment, we are able to provide a remarkable extraction process that is designed to suction out these pollutants deep within your carpets fibers right along with the water. This extraction procedure will leave your carpets cleaner and healthier, and they will dry in as little as an hour!
Do you continue to have questions? Give OxiGreen a call at 215-269-3331 and we will do our best to help you get right answers. We'll be glad to schedule a time to complete an absolutely free, healthy, household carpet inspection. We also have a website at http://oxigreencarpetcleaningpa.com so you might learn more about us. Check it out. You can also discover all about our many other services that includes tile and grout cleaning and more.
For a great green carpet cleaning company in Warminster, PA, choose OxiGreen. We won't disappoint.


text:
Discover the myriad of smoke inhalation incidents around the world.
oMask is an unparalleled solution to protect you against harmful gases.
Singaporean man found dead in burning JB house due to smoke inhalation. 22 March 2013, The Straits Times.
Factory fire at Loyang Industrial Estate; 3 workers sent to hospital due to smoke inhalation. 2 December 2013, The Straits Times.
Fatal fire in single-storey semi-detached house in Jalan Gaharu where Mr Tan Boon Chong and his son Spencer Tan Chee Phang died from smoke inhalation in a fire. 11 May 2014, Asiaone.
Teenager treated for smoke inhalation after fire breaks out in Joo Seng Road flat. 6 April 2014, The Straits Times.
Fire at Toa Payoh flat, three suffer smoke inhalation. 10 February 2013, The Straits Times.
4-year-old rescued from fire at Punggol flat and suffered from smoke inhalation. 10 February 2013, The Straits Times.
A fire broke out at a National University of Singapore (NUS) laboratory in the engineering faculty. One graduate student, who had been in the laboratory, and a security officer were taken to the National University Hospital for smoke inhalation. 5 April 2014, The Straits Times.
12 of 19 passengers and 1 of 2 flight attendants died due to smoke inhalation and fire on Singapore Airlines Flight 006.
The seven sailors suffered smoke inhalation and were airlifted from the submarine for treatment, navy spokesman Rahul Sinha said, without disclosing details of the incident. 26 Februar 2014, The Straits Times.
Hydrogen cyanide: Deadly HCN gas in fire smoke threatens responders.


Monkeys are fun and loving persons who are always cheerful and energetic. They are very clever. Give a monkey a boring book to read and he'll turn it into a Musical. Better yet, he'll invite everyone to see it free! That's how talented, creative and generous monkeys usually are.


text:
Mercer Wins Physical Battle Over Neighboring Anderson County
By Harrodsburg Herald | January 21, 2015 | 0
Mercer County junior Will Hager took the ball between two Anderson County defenders Saturday as he headed toward the basket.
It was a physical game when the Mercer County boys defeated neighboring Anderson County 71-66 Saturday night.
The game had 51 fouls (including one technical), six players fouled out and there were 64 free-throws attempted.
Mercer County Head Coach Josh Cook thinks the physical nature of the game will prepare his team come tournament time.
"This game was great for us because I felt like this was a regional tournament type atmosphere," said Cook.
Anderson County scored the first two points and led 7-4 two minutes into the game.
That was the last lead they would have.
The Titans tied the game not long after, on a three-pointer by junior Will Hager. It wasn't long after that they took the lead for good on a basket by junior Malik Dow, who finished with 20 points, 14 rebounds, five assists, three steals and two blocks.
With Mercer leading 16-13 and only 36.6 seconds remaining in the opening quarter, things started to get chippy.
It was at that time that Anderson County's leading scorer, Austin Cummins (22.9 ppg), received a technical found after throwing multiple elbows in the direction of Mercer's Jackson Baughman.
"I thought we kept our composure really well," said Cook.
Mercer freshman Trevon Faulkner hit the two ensuing free-throws as a result of the technical foul to give the Titans an 18-13 lead after one quarter.
The Titans controlled the second quarter behind the stellar play of Dow, who had six points in the quarter, and they took a 33-21 halftime lead.
"I just knew I had to step up tonight," said Dow.
Things continued to stay physical at the start of the third quarter as the two teams had seven fouls combined less than two minutes into the quarter.


text:
Michael Jaeger
Faegre Baker Daniels LLP
Michael Jaeger represents clients in complex litigation in the areas of business litigation, labor and employment, sports law, and product liability. Michael has litigated numerous matters in state and federal court as well as in arbitrations, including breaches of contract, consumer class actions, civil RICO, insurance matters, and collective bargaining disputes.
He has also advised retailers regarding best practices for online terms and conditions, specifically with regard to arbitration provisions and class action waivers.
Michael has argued motions, taken and defended depositions, second-chaired multiple arbitrations and mediations, handled preparation, direct and cross-examination of fact and expert witnesses, and conducted internal investigations.
He also has extensive experience drafting briefs and motions as well as negotiating and managing discovery. Before joining Faegre Baker Daniels, Michael was an associate with Latham & Watkins LLP.
Prior to practicing law, Michael was a director, working in various capacities on and off-Broadway, on national tours and in Los Angeles. He also co-wrote the feature film "The Best and the Brightest," starring Neil Patrick Harris, and he directed and produced live corporate events. Michael is an avid hiker and has logged many miles in the San Gabriel Mountains.
Loyola Law School, Los Angeles, J.D. summa cum laude; Order of the Coif; Senior Articles Editor, Loyola Law Review; Sayre Macneil Scholar (2012)
Yale University, B.A. in American Studies and Theater Studies, cum laude, with distinction in both majors (1993)
Bar Admissions : California
Court Admissions :
U.S. District Court for the Central District of California
U.S. District Court for the Southern District of California
U.S. Court of Appeals for the Ninth Circuit
Professional Associations :
Los Angeles County Bar Association
Association of Business Trial Lawyers, Los Angeles
What types of cases Attorney Michael Jaeger & Faegre Baker Daniels LLP can handle?
Faegre Baker Daniels LLP can handle cases related to laws concerning Litigation, Insurance, Employment, Class Action, Product Liability. We manually verify each attorney's practice areas before approving their profiles and reviews on our website.
Where is Faegre Baker Daniels LLP located?
Faegre Baker Daniels LLP is located at 11766 Wilshire Blvd #750, Los Angeles, CA 90025, USA. You can reach out to Faegre Baker Daniels LLP using their phone line 310.500.2161. You can also check their website faegrebd.com or email them at [email protected].
How much would it cost to hire Faegre Baker Daniels LLP?
Michael Jaeger lawyer charges are specific to each case. However, they work with contingency fees and its ranges from $$ to $$$. They also provide free consultation [and no obligation quotes] if you are interested to hire.
Are Michael Jaeger reviews trust-able?
We have the ratings and reviews moderation team who checks and verifies every review submitted on our website manually. You can trust all the reviews you see on Michael Jaeger lawyer profile listing.
Wilshire Boulevard 11766
Class Action Lawyer
Insurance Lawyer
Product Liability Lawyer
Michael Renetzky
Christina Dashe


text:
Such was our Good Fortune
Home / Such was our Good Fortune
Alex and Ron Banay says
I wanted to take a moment to let you know how much we appreciated working with Rick Whelan to achieve the sale of our property on Calderwood Road in Washington this week.
It must be pretty rare to buy a house and sell it forty years later through the same broker. Such was our good fortune. We remembered Rick from our interaction with him in 1978 as a man of patience and willingness to take on the resale of our property – in all honesty, not much changed from its original condition, and quite neglected. We found Rick to be courteous, respectful and honest, just as we remembered him. With the benefit of his long experience but also his strong feeling for Maine's landscape and history, he gave us good advice about the good points and liabilities of the property. Having helped us to position it in what was bound to be a limited market, he showed tireless energy in making it available to the twenty-five or so interested parties, dealing tolerantly with the vagaries of a house whose locks were balky, whose interior did not boast much appeal, where one room was unsafe to enter, and where honeybees had colonized an enclosed porch. He also helped us strategize about the three offers we received, not by exerting pressure but by quietly confirming our instincts as to what would be our best course. He conducted the whole process in a timely and thorough manner, kept us well informed of the process of our buyer's own sale, and made himself available whether by email or phone to iron out details.
It's a pleasure to pass along this observation, and we are grateful to Rick for making our difficult decision to sell as easy a process as we could have hoped.
Alex and Ron Banay


It is a long-awaited rank Inn in the quiz of the event of every day. It is 5th place.
And, I got this item.
Indeed, getting already might be people's to whom the quiz did the rank Inn knowing.
The number of participation certificates is also different because of the rank.
I got a familiar hat (having period) as two participation certificates and quizzes because I was 5th place.
Four pieces, hats, and the titles seem to have gotten 1st place according to the talk.
It is an original tool so. It took three days to make this.
However, it is not this at this because it is that a new item is added it is possible to hold this in the content of the quiz.
It is defrosted automatically to want to try this tool by downloading, and double-clicking it and give to me in wherever you like, please.
It only has to be able to read it because a detailed explanation has "readme.txt" while having defrosted.
Please there is a column to write it under a right side of this blog and it is input and transmit though it is in "readme.txt" about an of course uncertain point etc.
However, the support is not accepted for the problem sentence and the content.
Please acknowledge that the version of my tool might improve by a new problem sentence.


text:
Q: Drools project throws "The Eclipse JDT Core jar is not in the classpath" When I run the sample Drools project in Eclipse, it throws an Exception "The Eclipse JDT Core jar is not in the classpath". I have created the Drools 6 runtime manually. Am I missing something?
Full stacktrace
org.drools.core.RuntimeDroolsException: Unable to load dialect 'org.drools.compiler.rule.builder.dialect.java.JavaDialectConfiguration:java:org.drools.compiler.rule.builder.dialect.java.JavaDialectConfiguration'
    at org.drools.compiler.compiler.PackageBuilderConfiguration.addDialect(PackageBuilderConfiguration.java:360)
    at org.drools.compiler.compiler.PackageBuilderConfiguration.buildDialectConfigurationMap(PackageBuilderConfiguration.java:346)
    at org.drools.compiler.compiler.PackageBuilderConfiguration.init(PackageBuilderConfiguration.java:228)
    at org.drools.compiler.compiler.PackageBuilderConfiguration.init(PackageBuilderConfiguration.java:196)
    at org.drools.compiler.compiler.PackageBuilderConfiguration.<init>(PackageBuilderConfiguration.java:152)
    at org.drools.compiler.kie.builder.impl.AbstractKieModule.buildKnowledgePackages(AbstractKieModule.java:166)
    at org.drools.compiler.kie.builder.impl.KieContainerImpl.createKieBase(KieContainerImpl.java:244)
    at org.drools.compiler.kie.builder.impl.KieContainerImpl.getKieBase(KieContainerImpl.java:204)
    at org.drools.compiler.kie.builder.impl.KieContainerImpl.newKieSession(KieContainerImpl.java:347)
    at org.drools.compiler.kie.builder.impl.KieContainerImpl.newKieSession(KieContainerImpl.java:322)
    at com.sample.ProcessTest.main(ProcessTest.java:17)
Caused by: java.lang.RuntimeException: The Eclipse JDT Core jar is not in the classpath
    at org.drools.compiler.rule.builder.dialect.java.JavaDialectConfiguration.setCompiler(JavaDialectConfiguration.java:100)
    at org.drools.compiler.rule.builder.dialect.java.JavaDialectConfiguration.init(JavaDialectConfiguration.java:61)
    at org.drools.compiler.compiler.PackageBuilderConfiguration.addDialect(PackageBuilderConfiguration.java:356)
    ... 10 more

A: You are missing the Ecliose jdt core jar. Add yhat jar and it should work.

A: Added the org.eclipse.jdt.core-3.7.1.jar file to the buildpath of the project and it works perfectly fine. Not sure why this was not part of the Drools runtime which i created manually.


text:
Benjamin Gaines BOTTS
RESIDENCE: Richmond, VA
RESOURCES: See: [S1777] [S3560]
Father: John Minor BOTTS
Mother: Mary Whiting BLAIR
_Joshua BOTTS _______+
_Benjamin Gaines BOTTS _|
|                        |_Frances GAINES _____+
|                          (1755 - 1817) m 1771
_John Minor BOTTS ___|
|                     |                         _Charles TYLER ______+
|                     |                        | (1750 - 1793)
|                     |_Jenny TYLER ___________|
|                       (1780 - 1811) m 1798   |
|                                              |_Sally BROWN ________
|                                                (1760 - ....)
|--Benjamin Gaines BOTTS
|                                               _____________________
|                      _Archibald BLAIR _______|
|                     | (1770 - ....)          |
|                     |                        |_____________________
|_Mary Whiting BLAIR _|
|                         _____________________
|_Mary WHITING __________|
Hon. Gen. George William CHRISTIAN
1732 - ABT 1786
TITLE: Hon. Gen.
OCCUPATION: Rev War, Col Byrd's Regt; VA State Legislature; Pres. KY senate.
RESIDENCE: Staunton, Augusta Co. VA and 1785 Jefferson Co. KY
BIRTH: 1732, Staunton, Augusta Co. Virginia
DEATH: ABT 1786, killed by Indians in Indiana
BURIAL: Col.Christian's home, adjoining Oxmoor
RESOURCES: See: Bio [S2190] [S2793]
Father: Israel CHRISTIAN "the Immigrant"
Mother: Elizabeth STARK
Family 1 : Annie HENRY
Representative in state legislature of Va. in 1773-74-75-76-80-83; 1775 member of committee of safety. In 1785 he moved to Jefferson County, Kentucky and had 9000 acres on Bear Grass Creek, which he called the "Flower of Kentucky," near Louisville.
Pres. Ky. senate. Killed in 1786 leading a pursuit against Wabash Indians near Jeffersonville, Indiana. Christian County, Kentucky is named for him.
The burying ground is on "what was Col.Christian's home, adjoining Oxmoor, and is scrupulously cared for by the family, a permanent fund having been provided for the purpose, and is in the form of a trust in the hands of the Fidelity Trust Co."
Children: Priscilla, Elizabeth Bowyer, Anne Henry, Sarah Winston, John Henry, Dorothea, Elizabeth Bowyer.
"VI. Anne Henry((2)). Married George William Christian, son of Robert Christian, from Londonderry, Ireland, who settled in Augusta Co., Va., 1740; d. 1781, aged 90 years. Gen. William Christian was killed by the Indians near Louisville, Ky., in 1781. Issue:
I. One daughter((3)). Married Governor John Pope (From this marriage are descended the Warfields, Bullets, and Dickinsons, of that State.).
_Israel CHRISTIAN "the Immigrant"_|
| (1712 - 1784)                    |
|                                  |   __
|                                  |  |
|                                  |__|
|                                     |__
|--George William CHRISTIAN
|                                      __
|                                   __|
|                                  |  |__
|_Elizabeth STARK _________________|
(1715 - ....)                    |
Francis CONNER
RESIDENCE: Caroline Co. VA
BIRTH: ABT 1760, Virginia
Father: William CONNER
Mother: Frances WILLIAMS
Family 1 : Sarah Tilghman WOOLFOLK
_William CONNER _____|
|                     |                      __
|                                           |__
|--Francis CONNER
|                                            __
|                      _Rice WILLIAMS ______|
|                     | (1700 - ....)       |
|                     |                     |__
|_Frances WILLIAMS ___|
|_Frances DUNCAN _____|
James Edward FRIERSON Sr.
RESIDENCE: Williamsburg Dist. Craven Co. SC
RESOURCES: See: SEE NOTES - Poss Son Of Wm [S11] [S493]
Father: William FRIERSON "the Immigrant"
Mother: Mary
Family 1 : MCNEALY
George FRIERSON
James FRIERSON Jr.
Absolem FRIERSON
Letita FRIERSON
Mary FRIERSON
Elizabeth FRIERSON
Family 2 : DAVIS
MARRIAGE: AFT 1755, SC
Mentioned as son-in-law in James McKnealy's will of 1764. "America's Friersons Ancestry Book"; p. Main-7. By Meade Frierson:. James Edward Frierson, Sr. (1725? - 1778) married ? McNealy, who died circa 1755. He then married ? Davis, who died on May 6, 1777. It appears that this line of the Friersons later migrated to Mississippi, Louisiana and possibly Texas. You may wish to contact Meade Frierson at [email protected] [S493]
_(RESEARCH QUERY) FRIERSON of Williamsburg Dist. SC_|
|                                                    |__
_William FRIERSON "the Immigrant"_|
|                                  |                                                     __
|                                  |                                                    |
|                                  |____________________________________________________|
|                                                                                |
|                                                                                |__
|--James Edward FRIERSON Sr.
|                                                                                __
|                                   ____________________________________________________|
|                                  |                                                    |__
|_Mary_____________________________|
|                                                     __
|____________________________________________________|
[S493]
Horatio PENN
ABT 1812 - ABT 5 Apr 1859
RESIDENCE: Patrick Co. VA & Cape Girardeau, MO
DEATH: ABT 5 Apr 1859, Cape Girardeau, MO
Father: Abraham PENN
Mother: Elizabeth CHITWOOD
Deed from Abraham to "my son Horatio"; DB&, p. 139 Patrick Co, VA;
Settlement of estate of Horatio Penn by John Hobbs 4/5/1859 Cape Girardeau names heirs as Martha Hobbs (late Penn); Sarah Ferril (Casey Co., KY, MR shows Sally H. Penn to Levi R. Farrel 11/13/1832); Edmund Penn; and heirs of Abraham and Margaret (McDonald) Penn (underage): John W., Green and James Penn. Sibling: heirs of sibling of Horatio Penn.
_George PENN I________+
_Philip PENN ________|
|                     |_Ann FLEMING _________+
_Abraham PENN _______|
|                     |                      _William CRUTCHER ____
|                     |                     | (1720 - ....)
|                     |_Martha CRUTCHER ____|
|                       (1745 - 1802) m 1762|
|                                           |_Sarah________________
|                                             (1730 - ....)
|--Horatio PENN
|                                            _John CHITWOOD _______+
|                                           | (1718 - 1798)
|                      _Joel CHITWOOD ______|
|                     | (1750 - 1820) m 1779|
|                     |                     |_Elizabeth TILLOTSON _
|                     |                       (1720 - ....)
|_Elizabeth CHITWOOD _|
|                      ______________________
|_Sarah CANTRELL _____|
Mary POINDEXTER
RESIDENCE: New Kent and Goochland Cos. VA
BIRTH: ABT 1700, New Kent Co. Virginia
RESOURCES: See: [S1615] [S1956] [S2535] [S3304]
Father: George POINDEXTER
Family 1 : Benjamin (the Elder) MOSBY
MARRIAGE: ABT 1718, Henrico Co. Virginia
+Poindexter MOSBY
+Littleberry C. MOSBY of Font Hill
+Theodosia MOSBY
Mary Ann MOSBY
CONFLICT in Parent: Mary Poindexter; daughter of Benjamin Poindexter b. ca 1690 VA d. 1766 VA, probate 1766 Cumberland Co, VA. daughter Mary married Benjamin Mosby son of Edward Mosby and Sarah Woodson. Benjamin d 1774 Cumberland Co, VA. Married ca 1718 Henrico Co, VA.
_Thomas POINDEXTER (POINGDESTRE) _
_George POINDEXTER (POINGDESTRE) "the Immigrant"_|
| (1626 - 1715)                                   |
|                                                 |_Elizabeth EFFORD ________________
_George POINDEXTER __|
|                     |                                                  __________________________________
|                     |                                                 |
|                     |_Susanna BENSKIN ________________________________|
|                       (1635 - 1693)                                   |
|                                                                       |__________________________________
|--Mary POINDEXTER
|                                                                        __________________________________
|                                                                       |
|                      _________________________________________________|
|                     |                                                 |__________________________________
|                                                  __________________________________
|_________________________________________________|
|__________________________________
Ronnie REEVES


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text:
Tricky Shows His 'Vulnerable' Side
Ever evolving U.K.-based hip-hop/electronica artist Tricky has set a June 17 release date for his seventh studio album, "Vulnerable." The set will be released worldwide on the artist's own Brown Punk…
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Ever evolving U.K.-based hip-hop/electronica artist Tricky has set a June 17 release date for his seventh studio album, "Vulnerable." The set will be released worldwide on the artist's own Brown Punk Records label through Sanctuary, except in the U.K. and Europe, where it will go through Epitaph.
"I called this album 'Vulnerable' because it's my most honest and open record," Tricky said in a statement. "On this album I've stopped hiding and I'm allowing people to see different sides of the real me. 'Vulnerable' is me breaking free and being myself again."
Known for his work with evocative female vocalists, this time around Tricky recorded in Los Angeles with Italian singer Constanza Francavilla. Her voice is intertwined with Tricky's mix of electronic, hip-hop, and rock elements on such songs as "Stay," "Hollow," and first single, "Antimatter."
The enhanced CD will feature the Stephane Sednaoui-directed video for "Antimatter," as well as an interview with Tricky, and three guerilla-style films conceived and co-directed by the artist. The "Antimatter" video will be premiered in Paris at Palais de Tokyo during a month-long exhibition of Tricky's digital photography that opens April 29.
Tricky's European 13 Tour will kick off June 13 in Vicenza, Italy. Prior to a fall North American tour that is still in the planning stages, he will produce Francavilla's debut album, which will also be released via Brown Punk.
"Vulnerable" is the follow-up to the 2001 Hollywood release "Blowback," which debuted at No. 3 on Billboard's Top Electronic Albums chart.


text:
Brandview / Sub-sections: More sections »Robert J DebryIntermountain HealthcareU of U HealthMountainStar HealthCareSalt Lake Chamber
How a Utah private school leads the way in science, tech, engineering, math and more
By Our Lady Of Lourdes | Posted - Nov 23rd, 2019 @ 8:00am
This story is sponsored by Our Lady of Lourdes.
As a parent, you've probably heard of STEM classes — science, technology, engineering and mathematics. While they may seem daunting and give you an extra hour of homework help at night, they are critical to a child's education.
Florida State University says people working in the STEM fields tend to make 26% more money than their non-STEM counterparts. While you're not necessarily planning out your elementary student's career path at this point in life, the choices you make now will affect his or her career later on.
STEM classes are vital for a child's education, but a Salt Lake City school says that the acronym is missing one important letter — A for art. That field of study may seem out of place, considering the logical base of the science and math classes of traditional STEM classes. However, having an art class in the mix is essential for your child's education.
Our Lady of Lourdes Catholic School in Salt Lake City is adopting this form of education, as recommended by Next Generation Science Standards.
At Our Lady of Lourdes, children of all grades participate actively in the learning process with hands-on experiences. While science classes focus on physical, life, earth and space sciences, the education gained in hands-on learning is unparalleled.
Students are expected to take a hands-on learning approach in the science classes at the school. Every year, they are required to participate in the science fairs (grades 6-8) or class science projects (K-5).
In the math portion of learning, students can expect a rigorous program to prepare them best for high school math. Since more than 90% of students attending Our Lady of Lourdes move on to attend Judge Memorial High School, the educators actively collaborate with Judge Memorial math teachers. Students and parents can rest assured they will know the material needed for high school math classes.
For those students with a particular aptitude for mathematics, there is an Advanced Math Program designed to accelerate learning.
"At the end of eighth grade, students in the program will have completed freshman geometry, integrated with students at Judge Memorial Catholic High School," reports Intermountain Catholic.
"One goal of the program is to give advanced math students the opportunity to test out of freshman math and enter an honors or higher-level math course at the start of high school."
The timeliness of the Advanced Math Program couldn't be better. The National Science Foundation estimates that 80% of the jobs available over the next 10 years will require math and science skills.
Our Lady of Lourdes bases its curriculum on the International Society for Technology in Education's (ISTE) standards to make sure classroom instruction is relevant and applicable.
Group-centered, but self-directed exchanges lead to authentic, collaborative assignments within STEAM contextual boundaries.
Students are exposed weekly to instruction in hardware, software, connectivity basics, keyboarding, coding (Scratch2) and digital information access and research, according to the school's website.
While engineering might seem like a difficult college class, it's essential to start teaching it while children are young. Our Lady of Lourdes students receive hands-on engineering experience with do-it-yourself prototyping and a state-of-the-art engineering platform.
"Students are inspired to learn and invent by using the littleBits™ platform of electronic building blocks in a hands-on, discovery-based environment that fosters analytical thinking, collaboration and challenging outcomes," the school's website states.
In collaboration with the core science teachers, engineering topics are chosen that correspond with current science and history units being taught.
While it may seem as though art is an outlier in the STEAM combination, it's actually seamlessly interwoven with the other classes. Students learn about media arts in the technology course of classes. Additionally, students take a visual arts course to build creative skills.
The Our Lady of Lourdes website says all students participate in the Meet the Masters™ program. They learn about a master artist, the historical impact and significance that artist's work had on society, and of course, the artist's technique. They then use different mediums to produce works of art.
In addition to art classes, students take music history and appreciation classes all the way from kindergarten to 8th grade. In addition to those weekly classes, students also participate in liturgical and choral music classes and perform in an annual Christmas Program.
STEAM for success
Parents and students interested in enhancing K-8 education are encouraged to learn more on the Our Lady of Lourdes website. Contact the school for a tour to learn more about the program and enrolling your child.


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De Slag bij Trois-Rivières was een slag tijdens de Amerikaanse Onafhankelijkheidsoorlog , die plaatsvond op 8 juni, 1776 nabij Trois-Rivières in Quebec, Canada. Een Brits leger onder leiding van de gouverneur van Quebec, Guy Carleton, die een aanval van de kolonisten afsloeg, won een tegenaanval van John Sullivan.

Het koloniale leger in Canada had een ernstige nederlaag geleden bij de rampzalige Slag bij Quebec (1775) op oudejaarsavond 1775. Dankzij een grote aanvoer van middelen en versterkingen konden de Amerikanen hun aanwezigheid in de buurt van de stad Quebec blijven handhaven in de loop 1776, maar een superieure Britse artillerie maakte het beleg onmogelijk en ziekte dunde de rangen verder uit.

In mei zeilde een hulpeskadron van de Royal Navy naar de haven van Quebec. Dit werd aangevuld met 4 infanterieregimenten en Hessische troepen uit Brunswijk . Onder de leiding van Carleton werd een aanval op de kolonisten ingezet. Sullivan voerde een tegenaanval uit nabij Trois-Rivières, maar Carelton kon die pareren. Alhoewel Sullivans manschappen verslagen waren door de Britse infanterie, kregen de meesten van zijn manschappen wel de kans om naar Montreal te ontsnappen door de overvoorzichtige houding van Carleton.

Bij Britse raids in de ruime omgeving van Montreal tijdens de lente van dat jaar werd bijna 500 man gevangengenomen in gevechten bij Fort Cedar en bij Vaudreuil. Omdat hij het gebied niet onder controle kon houden, verliet Benedict Arnold Montreal op 15 juni na nog gepoogd te hebben de stad in brand te steken.

Referenties

Trois-Rivieres
Trois-Rivieres
Geschiedenis van Quebec
1776