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Dr. Annamarie Bindenagel-Šehovic is a Research Fellow at PAIS at the University of Warwick. Her research explores the trajectory of health responses overall and to HIV in particular within the frame of human security. It focuses on the articulation of health rights, the invocation of such nationally and globally. Through the EL-CSID project she is working on tracking knowledge transfer on the individual, state and global levels in the provision of health(care). Prior to coming to Warwick, Dr. Šehovi? was a lecturer in international relations at the University of Erfurt, Germany, and as the founder of Bindenagel Consulting, cc, spent years in South Africa working with the African Institute of Corporate Citizenship, BenchMarks Foundation, Daimler, the University of Pretoria's Center for the Study of AIDS, and others. She earned her PhD at the FU Berlin in 2016; her MA in Public Policy at the University of the Witwatersrand in Johannesburg, South Africa in 2006, and her BA (honors) at the University of Notre Dame in the U.S.A. in 2003.


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Dedication to John Higgitt
2. Current state of knowledge
2.1 Prehistoric rock art
2.2 Roman
2.3 Early Medieval
2.4 Later medieval
2.5 Architectural sculpture
2.6 Gravestones
2.7 Public monuments
2.8 Heritage and conservation
3. Creating Knowledge and Understanding
4. Understanding value
5. Securing for the future
6. Engaging and Experiencing
7. Looking forward
8. Carved Stone Workshop Documentation
10. Published Sources
Roman military intervention in Scotland has left behind a rich legacy of carved stone monuments dating from the late 1st to the early 3rd centuries AD (Keppie 1998a). The majority are formal, inscribed public monuments, made by and for non-local military personnel, or civilians operating within a military milieu. These include: stone altars (erected in fulfilment of a vow to native and non-native deities), tombstones, milestones, dedications to the Emperor, architectural pieces, and the distance slabs (of which 19 survive) carved to commemorate the completion of different sections of the Antonine Wall by various legions in AD 142–3 (Keppie 1998b; Breeze 2006). In form and decoration, most of these monuments are of a type familiar from elsewhere in the Empire, however, the Antonine Wall distance slabs are unique—nothing similar has been found on any other frontiers of the Roman Empire (Keppie 1979).
Inscriptions―in Latin and often highly abbreviated—dominate most of these monuments, and their testimony has been crucial to efforts to understand the military and religious history of the Romans in Scotland. Not all monuments are inscribed and, even those which are, frequently also feature a range of decorative motifs and classical imagery designed to convey statements about military might and religious piety. The finest are indeed splendid monuments, elaborately decorated and exhibiting very high levels of workmanship. The corpus also encompasses much humbler material, of cruder (presumably non-professional) quality. These include informal doodles and scratched inscriptions, for instance those recording work done or loads delivered on building blocks from Easter Langlee, Roxburghshire.
Scholarly interest in Scotland's Roman period carved stones dates back at least to the late 17th century, when the University of Glasgow invited landowners (many of whom were alumni) to donate Roman stones in their possession. These gifts formed the nucleus of the significant collection of Roman sculpture, particularly from the Antonine Wall, housed in the University's Hunterian museum (Keppie 1979; 2014a) (Figure 9). Although some Roman altars are still landscape features, and a few remain in private hands, the great majority of Roman carved stones are in museums. In addition to the substantial collection in the NMS, there a number of pieces in museums in Dumfries, Dundee, Perth, Melrose and Falkirk.
Figure 9: Antonine Wall distance slab from Hutcheson Hill, Bearsden (RIB 2198), commemorates work on a 3000 ft section by the Twentieth Legion in AD 142–3. Discovered in 1865 it was taken to North America in 1871 where it was destroyed by fire. It is known only from this plaster cast. H. 0.67m. Hunterian Museum. © Sally Foster
Sculpture, especially inscribed sculpture, is fully integrated into wider studies of the Romans in Scotland and has often played a crucial role (as the Antonine Wall slabs did in piecing together the making of the wall). Usually, however, Roman carved stones have been employed to answer questions arising in other fields rather than be a focus of research, generating new questions, in their own right. The predominant approaches are iconographical and epigraphical. Accounts of individual inscriptions have typically been published in specialist journals but an overview of the Scottish material is most easily gained from the standard corpora: the total of 125 inscriptions then known from Scotland were included in Collingwood and Wright's definitive corpus of Roman Inscriptions of Britain (1965), updated by Keppie (1983) to include a further 19 found between 1954 and 1983. Approximately half the total of inscribed stones are also sculptured, i.e. bear figural or abstract decoration, and these, together with a further 100 or so uninscribed sculptured stones (including architectural fragments) were published by Keppie and Arnold (1984) as fascicle 1.4 of the Corpus Signorum Imperii Romani (Corpus of Sculpture of the Roman World): Great Britain.
Figure 10: Cramond lioness. Roman funerary monument in the form of a tomb guardian lioness. Local features include the savage jaws of the creature and the fact that its prey is a captive male barbarian. Found in the vicinity of the Roman fort of Cramond, it is presumed to have marked the grave of an important dignitary stationed there. Late 2nd/early 3rd century AD. Now in the NMS. L 1.51m. © Trustees of the National Museums of Scotland
Since the publication of these corpora, new finds have continued to be made and are typically reported in the journal Britannia. Notable discoveries include the two highly accomplished altars discovered in 2011 during grave-digging in a cemetery that lies within the site of the Roman auxiliary fort at Inveresk, near Musselburgh. Surely the most spectacular recent find is the so-called 'Cramond lioness', a monolithic 'tomb guardian' found in silt at the mouth of the river Almond (Midlothian) in 1997 (Figure 10). It is a local variant of a typical Roman form but differs in depicting a bound male prisoner being devoured by a lioness. It dates to the late 2nd or early 3rd century AD and would have served as part of the tomb of a Roman military commander or dignitary, connected to the nearby Cramond Roman fort.
Monuments such as these provide firm evidence for the occupying forces of an imperial power—there is no evidence that stone carving was adopted by the local population, even though many of these monuments would have been visible to them in the landscape. Not until the 5th century does stone carving become established in Scotland. The earliest post-Roman carved stone monument from Scotland—the 5th-century Christian inscribed pillar from Whithorn, Galloway—is a product of a continuing Roman tradition lingering on in the zone around the Hadrian's Wall frontier (reflected in aspects of its lettering, spelling and layout: Forsyth 2009).
For further reading, download the Section 10.2 pdf ( 272kb).

redpajama_set_name: RedPajamaCommonCrawl


Red and Gold is a fun, competitive and cooperative student-run activity guided by faculty moderators. Each team, Red and Gold, competes for points with entrance, cheering, aerobics, dance and spirit routines, as well as collaborative team cooperation. Senior students are voted into captain positions to create themes, make routines and teach them to the underclassmen, design costumes, demonstrate leadership, and communicate with the faculty moderators.
The revealing of the routines begins the first week of January, including and dress rehearsal run-through at Sacred Heart Academy and grand finale at Hofstra University, which is judged by professionals. It is on this evening that the winner is announced. This activity requires students to practice five to six times a week for about two hours at Sacred Heart Academy or at other local locations. Although Red and Gold demands hard work and dedication, nothing compares to the bonding experience among students and faculty, long lasting friendships, and pride for Sacred Heart Academy.


St Mary's takes seriously the preparation and Service of Admission of Children to Holy Communion. Children aged seven or over prepare for admission by attending a short series of sessions with the priest so they can ask questions and explore their faith.
Before they start their preparation, the children are introduced to the congregation to ask for their support.
Children receiving communion for the first time play an active part in the service. It is a joyful event for our congregation to celebrate this very important step in the lives of the children of St Mary's.
Once they are communicants, many of our children train as acolytes and help the priest in the ceremonial duties during the services.
If your child would like to become a communicant, please contact the Church Office.


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Peya Kaanom () is a 2022 Indian Tamil-language horror comedy film directed by Selva Anbarasan and starring himself, Meera Mitun and Kausik in the lead roles. It was released on 23 December 2022.

Cast
Selva Anbarasan
Meera Mitun
Kausik
Sandhya Ramachandran
Kothandam
Madurai Mani
Tarun Gopi
Jaguar Thangam

Production
In July 2021, reports emerged of a fallout between the film's director Selva Anbarasan and actress Meera Mitun about her smoking on-set. In December 2021, Selva alleged that Meera had absconded from the shoot of the film in Kodaikanal. The director added his general sadness over Meera's behaviour noting "she never valued the time and efforts of other stars and technicians" involved in the film shoot. Eventually, the director managed to complete the shoot without Meera Mitun.

During the promotions of the film, Selva Anbarasan sarcastically thanked Meera Mitun for promoting the film through her absence, while alluding to the title of the film.

Reception
The film was released on 23 December 2022 across Tamil Nadu. A reviewer from the Madurai-based Thinaboomi newspaper gave the film a negative review, noting that "it was not a funny film". Critic Malini Mannath noted "with neither horror nor comedy going for it Peiya Kaanom is a film better forgotten" and added "that it's the work of a debutant is evident all the way through, both in its amateur writing and in the shoddy execution".

References

2022 films
2020s Tamil-language films
Indian comedy horror films

redpajama_set_name: RedPajamaWikipedia


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Mike Andersen is a Danish blues guitarist and vocalist. His music is defined by the love for classic soul and blues which has led him in a soul-blues crossover direction.
The quality and originality of the music gives it an international expression and Mike Andersen has managed to establish popularity and a great fan base in Denmark but also internationally.
Mike Andersen is an experienced artist in the music industry with 7 albums and more than 1500 shows played including 27 shows at international music festivals. He has played in several countries from England, the Netherlands, and Hungary.
The blues and soul artist has been nominated for a Danish Music Award six times and in 2015 he won the award for Best Blues Album with his album "Home" from 2014.
On his recent album "Devil is Back" (2016), the exceptional quality of Mike Andersen is accompanied by the British soul singer Joss Stone who joins Mike on the duet "This Time".


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Width 136cm x Depth116cm x Height 199cm. The item "Garden Patio Swing Chair Double Armrest Porch Hanging Egg Shaped Cushioned Seat" is in sale since Sunday, March 24, 2019. This item is in the category "Garden & Patio\Garden & Patio Furniture\Garden Chairs, Swings & Benches". The seller is "plandealshop" and is located in London.


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Q: Android SDK override AlertDialog events I am instantiating an alert dialog like so:
AlertDialog myAlert = new AlertDialog.Builder(myContext).create();

Is there a way to override the OnKeyDown event for this dialog?

A: AlertDialog.Builder build=new AlertDialog.Builder(this);
build.setMessage("This is a message, dawg.")
.setPositiveButton("Awesomesauce.", new OnClickListener()
{
    public void onClick(DialogInterface dialog, int id)
    {
        //stuff here
        dialog.dismiss(); //closes the window
    }
};
AlertDialog myAlert=build.create();
myAlert.show();

You can also add a .setNegativeButton() or .setNeutralButton() to change the neutral/negative buttons, too.
The Android SDK doc for it is here.

redpajama_set_name: RedPajamaStackExchange


Taking advantage of the many opportunities at the Chamber is beneficial to your business. Being active on a committee affords you the opportunity to meet new contacts and help both the Chamber and Community as well. Why not consider joining a committee today? Contact the Committee Chairperson or the Chamber Office at 860 388-3266.
Each December, the Annual Meeting is held commemorate our year and to approve the Board of Directors slate for the following year. We announce The Business of the Year, the Non-Profit Business of the Year and Volunteer of the Year.
Committee members assist with planning and execution of the event of this annual 2-Day Event that boasts 150+ artisans & crafters exhibiting on the Old Saybrook Town Green.
Committee plans and organizes the annual Expo to promote business-to-business networking, showcase member products & services and invites the community to visit each booth.
March 3, 2018 marks the 22nd Annual Outdoor Winter Community Event.
Committee assists in recruiting, marketing and execution of this event – 20+ years strong. 30+ chili recipes are cooked by chamber members – tasters purchase ballots and vote for their favorite chili. Proceeds benefit the Chamber's Scholarship Fund.
3rd Annual Event to be held September 16, 2018 at the Lorensen Auto Mall.
6th Annual Golf Tournament at the Lake of Isles-South Course October 2018. This event is held on Foxwood's private course and is special in every respect!
Continuing to enhance our relationship and schedule bi-annual forums with our Senators and Representatives. Dates of our forums to be announced.
The Wellness Committee meets the second Wednesday of the month.
Committee meets monthly from January through December.
Ambassadors serve as public relations support for the Chamber of Commerce. They assist the Chamber's recruitment and retention efforts through personal interaction and involvement; help to host Chamber events; visit new and existing members and ascertain feedback. The team helps to develop member services relevant to the Chamber mission and member needs.
The Marketing/Tourism Committee promotes the Chamber to the community, chamber members and potential members. Develops Chamber 'Brand' and works with EDC to develop and market the town/region for attracting businesses and residents as well as promoting tourism.
An opportunity for members to network with others in a fast-paced roundtable session. Meetings are held the 3rd Wednesdays of the month 8am-9am. Check website calendar for location.
A collaborative initiative for women in business - providing luncheon and evening programs educating women in leadership, development, mentoring and networking.
Committee develops the scholarship application, screens applicants and selects the winners of the Annual C. Wilfred Hunter Memorial Scholarship.
We are a very busy office and volunteers are the backbone of our organization, doing everything from answering phones and helping visitors in the office to assisting at the many events throughout the year. They are energetic, community-minded individuals, volunteering a couple of hours per week, who enjoy being in the center of the action. We genuinely value their time and dedication to keeping things running smoothly.
We put on numerous events throughout the year, most famously our Chili-Fest where over 30 businesses participate in a town-wide chili cooking contest to raise scholarship money for high school seniors. We also have an annual Arts & Crafts Festival, enjoyed by all in town. As you can imagine, with such a busy schedule, we are grateful for any and all help we can have at our 20 or so events throughout the year.
We always welcome new community members so to volunteer please call 860-388-3266 or stop in Monday through Friday anytime from 8:30-4:30.


Mike Strauss' body is seized, Ike reacts to a break-in, and Victor plots to get his wife out of Cuba. Vera secures Jackie Kennedy for a charity event but laments not having children with Ike.
Ike is determined to save Judi Silver from Ben Diamond. Polaroids of Stevie and Lily surface. Vera tries something new to get pregnant, Danny and Mercedes' bond grows, and Klein's search ramps up.


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Jennifer Peck understands that when challenging times arise, it is important to have someone on your side, to provide guidance and tools necessary to make informed decisions about your future. Ms. Peck offers compassion and honest direction to her clients throughout the entire legal process, and fiercely advocates for the most advantageous outcome possible.
Ms. Peck has extensive experience representing clients in various family and juvenile law cases. She is also a Rule 31 certified family mediator who has facilitated hundreds of disputes in which each party plays a role in identifying a resolution both can agree upon. In addition, Ms. Peck practices real estate law. She is a licensed affiliate real estate broker, which is advantageous when evaluating complex details of a case to determine the best options for resolution.
A native of Chattanooga, Ms. Peck graduated from The Baylor School. She received her undergraduate degree from Auburn University and earned her Juris Doctor from Regent University School of Law in Virginia Beach, Virginia. Before opening her practice, Ms. Peck worked with a local firm where she primarily handled divorces and custody cases, providing a strong foundation from which to build. In 2010, she launched her own practice in Chattanooga, successfully expanding it by building a solid reputation for her work, broadening the firm's areas of legal service, and adding associates with diverse experience and skills.
Ms. Peck is actively involved in several professional organizations and is an adjunct professor at the University of Tennessee Chattanooga, currently teaching Juvenile Law.


VIOLETA WENT TO HEAVEN tells the story of famed Chilean singer and folklorist Violeta Parra, tracing her evolution from impoverished child to international sensation and Chile's national hero, while capturing the swirling intensity of her inner contradictions, fallibilities, and passions.
From the marquee that she built in Santiago, Chile, Violeta Parra is visited by people who shaped her life. We gradually find out her secrets, fears, frustrations and joys, not only through performances of her multiple works but also through her memories, her loves, and her hopes. Her achievements are suspended in a passionate journey with the characters who made her dream, laugh and cry.
Interested in bringing Violeta Went to Heaven to your school or library? If you'd like to have an in-class viewing, on-campus screening, or purchase the DVD for your library's collection, please contact Estelle Grosso or call (212) 629-6880 with your request.
Violeta Went to Heaven may also be available with Public Performance Rights (PPR) and Digital Site Licensing (DSL) for colleges and universities. To purchase the DVD with PPR or DSL, please contact Estelle Grosso or call (212) 629-6880. Click here to learn more at Kino Lorber Edu.


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text:
What's happening in Central Jersey: Aug. 25 and later
Brad Wadlow
@BradWadlowMyCJ
'Can-Do' Connection to meet Wednesday at Bernardsville Public Library
Somerset County Park Commission has entered into a collaborative arrangement
JCPenney shoppers can help JCPenney Cares program
Central Jersey Business Alliance to hold "Networking Event" on Thursday in East Brunswick
See 'Peabody & Sherman' moive outdoors
The Bernards Township Regional Chamber of Commerce has partnered with the Long Hill Township Library and Millinton Savings Bank to host the "Mr. Peabody & Sherman" movie at 8 p.m. Wednesday (Aug. 27) in the Millington Savings Bank parking lot, 1902 Long Hill Road, Millington.
The movie is "free" to attend and guests are encouraged to bring lawn chairs and blankets.
This is a new version of the classic television comic series featuring Mr. Peabody, a genius dog, and Sherman, the boy Mr. Sherman adopts. The film was released in theaters earlier this year, but has not yet been released to DVD.
The outdoor showing of the movie is made possible by support of fellow Bernards Township Regional Chamber of Commerce members Pulse Stage Lighting and the Bernardsville Columbus Club. "The Columbus Club raises funds through pro wrestling events in Stirling. This is a wonderful way for us to give back to this community that has come out to support the pro wrestling events," said Lisa Heubach, of the Columbus Club, in a prepared statement.
"Everything came together quickly, with the movie being such a new release, we hope it provides those still around for the summer, a nice family evening out," Bernards Township Regional Chamber of Commerce President Al LiCata said.
In case of inclimate weather for the Aug. 27 outdoor date, the movie will be shown indoors at the Long Hill Township Library at 8 p.m. Thurday (Aug. 28). The Long Hill Library is at 917 Valley Road, in the Gillette section of the township.
For additional information, or to become a sponsor of upcoming Chamber events, call the Bernards Township Regional Chamber of Commerce at 908-766-6755.
Bradley W. Wadlow
'Can-Do' Connection to meet Wednesday
The "Can-Do" Connection will meet at the Bernardsville Public Library on Wednesday (Aug. 27).
Professional Inspirer Andrea Mastrobattista will lead a workshop where you will learn how to love the work tasks you hate. The program begins at 7 p.m.
Mastrobattista has been leading her inspirational workshops on Wednesday evenings at the library since 2006. She heads a company called Operation INSPIRATION and also facilitates workshops in the Somerset Hills. Her core belief is that, no matter what circumstances people face, they have the strength and ability to create and live fulfilling and inspiring lives.
There is no charge to attend the library workshop, but advance registration is requested. Register at www.bernardsvillelibrary.org, and follow the link from Adult Programs, or call the library at 908-766-0118 to sign up.
Bernardsville Public Library is at 1 Anderson Hill Road.
Commission enters into an agreement
The Somerset County Park Commission, led by the Ranger Division, has entered into a collaborative arrangement with the Raritan Headwaters Association to promote an educational initiative to protect the Raritan River from the introduction of invasive species.
The Headwaters project is funded by an Audubon Toyota TogetherGreen fellowship and focuses on spreading awareness about the nuisance alga, didymo, and the importance of leaving no trace of visits to the streams and rivers enjoyed by fisherman, kayakers and boaters.
The basic "Leave No Trace" principle being promoted is to have fishermen, kayakers, boaters, and other stream recreationalists regularly inspect their gear including removal of rocks, mud, plants, moss and other materials; thoroughly cleaning equipment to remove any attached materials; and completely dry equipment in the sun following use.
Park Commission Rangers will serve as a positive presence at parks and Commission events to educate visitors on the importance of taking personal responsibility for keeping the Raritan River healthy, clean, and safe. In addition, "Leave No Trace" flyers will be posted at Park Commission facilities along the river.
For more information on the "Leave No Trace" program email Angela Gorczyca at agorczyca@raritanheadwaters.org or call 908-234-1852 ext. 315. Information on all Somerset County Park Commission activities may be found at www.somersetcountyparks.org.
CENTRAL JERSEY
JCPenney shoppers can help program
Throughout the month of August, JCPenney shoppers can round up their purchases to the nearest dollar and donate the difference to support arts in education.
Contributions will be donated to JCPenney Cares to help fund national and local arts education programs through partnerships such as Young Audiences Arts for Learning, the nation's largest arts-in-education organization.
Through round-up donations, JCPenney Cares funding will support everything from classroom resources, like instruments and art supplies, to basic teacher needs allowing for an impactful and art filled experience. The arts play a role in helping students develop the kind of innovative skills that, when combined with a STEM education, position America's youth to better compete in the 21st century marketplace. Young Audiences New Jersey & Eastern Pennsylvania is an affiliate of the Young Audiences Arts for Learning network.
For more information on Young Audiences New Jersey & Eastern Pennsylvania, visit www.yanj-yaep.org. Join them on Facebook and follow them on Twitter @YANJEPA. For more information on JCPenney, visit www.jcpenney.com.
Alliance to conduct a 'Networking Event'
Join the Central Jersey Business Alliance (CBA)'s "Networking Event" on Thursday (Aug. 28) at LA Fitness from 5:30 to 7:30 p.m. The event is hosted by LA Fitness and sponsored by LA Fitness and Carol's Creative Chocolatez. The cost is $10.
The CJBA is an alliance of Central Jersey businesses, whose sole purpose is for the betterment of the retailers, service providers and health professionals who reside in Central Jersey. If you have a business in Central Jersey, reserve a seat by emailing wanttoattend@gmail.com. Space is limited. Non-members may attend two programs prior to joining the CJBA.
LA Fitness is at 341 Route 18. Call 732-690-5496.
Monthly luncheon to be held at center
Meals on Wheels in Hunterdon is hosting its monthly luncheon "Beach Party," on Thursday (Aug. 28) at 11:45 a.m. at the Flemington Senior Center, 4 Gauntt Place, lower level.
All are invited to come out and enjoy lunch and experience a media presentation on the world's most beautiful beaches. Hunterdon County residents 60 and older are welcome to attend.
Call Meals on Wheels at 908-284-0735 to make a reservation.
Posts are holding membership drive
American Legion Posts throughout Middlesex County are conducting an early bird membership drive through Labor Day.
Eligible veterans who join now will get the rest of 2014 and all of 2015 included in their membership fee.
The American Legion, chartered by Congress in 1919, is the nation's largest wartime veterans service organization. It is committed to mentoring youth and sponsorship of wholesome programs in communities; advocating patriotism and honor; promoting strong national security; and devotion to fellow service members and veterans. Their continued success depends upon the involvement of the veteran community.
The benefits to eligible veterans, reservists and active duty personnel may include reduced rates on hall rentals; assistance with entitlement issues; participation in a variety of post sponsored events; and involvement in community activities such as Boys State, children's coloring contests, scholarships, American Legion baseball, Boy Scouts, programs for hospitalized veterans, hosting Memorial and Veterans Day services, and many others.
Through the American Legion, members receive discounts on hotels, car rentals, eyeglasses, computers, the ability to participate in members-only insurance and prescription plans, and a subscription to The American Legion Magazine and New Jersey Legionnaire newspaper. In addition, members are welcome at other American Legion posts worldwide.
For more information, to check eligibility dates, receive an application or find your nearest post, email Gary Cooper, county membership chair, at alpost401@hotmail.com.
Ungar will present songs of war years
"Songs of the War Years," will be presented by Skip Ungar on Thursday (Aug. 28) at the Mountainside Public Library.
The program runs from 7:30 to 8:30 p.m. Ungar will play the piano and sing songs of the war years, starting with the American Revolution through the War of 1812, the Mexican War, the Civil War, the Spanish-American War and both World Wars. The program will include unknown lyrics to "Yankee Doodle," the lesser known words of the "Star Spangled Banner," "Dixie," "Over There," "This Is The Army," and more. It will also feature pop songs of those times, and European songs from wars in which America was involved.
To register, call the library at 908-233-0115.
Mountainside Public Library is at 1 Constitution Plaza.
County earns yet another ranking
Somerset County recently was named one of the best places in the U.S. to live; now it has been ranked as one of the happiest, too.
At about the same time that Movoto.com's real estate blog was proclaiming Somerset the fifth best county in the nation, the National Bureau of Economic Research cited the Middlesex-Somerset-Hunterdon region as No. 10 in its Top 10 list of happiest metro areas.
"We have many things to be thankful for here in Somerset County, and I think our quality of life has a definite impact on residents' happiness," said Freeholder Director Patrick Scaglione, in a prepared statement. "Our educational institutions, government services, recreation areas, employment opportunities and housing options are among the best anywhere."
The 10 happiest metro areas with populations over 1 million as of 2010 were identified by the private, nonprofit research organization as Richmond-Petersburg, Va.; Norfolk-Virginia Beach-Newport News, Va.; Washington, D.C.; Raleigh-Durham, N.C.; Atlanta, Ga.; Houston, Texas; Jacksonville, Fla.; Nashville, Tenn.; West Palm Beach-Boca Raton, Fla.; and Middlesex-Somerset-Hunterdon, N.J.
To stay up to date with Somerset County events and information, sign up for free email alerts at www.co.somerset.nj.us/subscribe.html or follow them on Facebook at www.facebook.com/SomersetCountyNJ and Twitter at twitter.com/somersetcntynj.


text:
News & Update Articles >
Final Fantasy XIV – 'A Nocturne for Heroes' Event Guide
by Jason Parker
@IshyJulu
The Final Fantasy XV crossover with Final Fantasy XIV is in full swing in Square-Enix's MMORPG, and though it is planned to end on May 27th, you still have time to get in, complete the three quests, and earn the best prize of all: The Regalia. The ultimate prize of this crossover is a four-seater mount that plays one of the most mellow Final Fantasy XV tracks. You do not receive the Regalia for completing the quest chain though – that comes later. It does require some MGP (Gold Saucer currency), but I go into that below. The actual quests to get through to the end battle are fairly easy. In order to begin this quest, you must first be level 50 on a DoW/DoM class (so not a crafter/gatherer) and have completed "The Ultimate Weapon" Main Story Quest. The actual quest chain begins near the Aetheryte in Ul'dah (x8.5, y9.7).
Kipih Jakkya is your point of contact alongside Noctis of Final Fantasy XV. At Black Brush, you meet a strange young man with an awesome black car, that being Noctis and the Regalia. The major point of the quest "The Man in Black" has you completing the "Like Clockwork" FATE, which takes place in Central Thanalan (The Clutch). You'll fight a giant Magitek Trooper/Mech, but even if you're the only person doing it, Noctis will still help you fight. It's a pretty cut-and-dry battle, don't stand in the big AOEs, hit it in the face. You'll do a lot of traveling around the world with this quest, but there are only three major battles. That was the first one. This first battle's pretty easy, and the next one is if you just listen to Noctis. You'll also receive Noctis' Fingerless Gloves as a reward.
From there, "In The Dark of Night" has you traveling around Gridania, but starts in the same location as "The Man in Black". Ultimately, you find yourself in East Shroud, and there's a solo boss fight (thankfully with an assist from Noctis), where you fight Iseultalon. Honestly, this fight is pretty easy too. The fiend has a tail whip it uses twice, and whatever the safe spot is for the first, it will be opposite of it on the follow-up swing. The major point to be aware of is he'll do a little dance, and behind you, a pair of pillars will appear.. You need to run to those in time, to avoid taking massive AOE damage. Noctis will run to one, and you need to head to the other one. Otherwise, you'll just take the damage anyway. Not a difficult encounter, Noctis doesn't take a whole lot of damage in this one. Your reward here is Noctis' pants. I hope he has extras of these. This is supposed to be a PG-13 game!
"The Messenger of Winds" is the final quest, and here's where I ran into a bit of trouble. Noctis gives you this quest in The Knot (New Gridania – x11.4, y11.3), and Noctis just wants to unwind. You'll have a chat with Kipih Jakkya, and after more cutscenes, your goal is clear: Fight Garuda! This isn't the same Garuda you've already fought, this is Garuda from EOS, though it does take place in The Howling Eye. For this fight, you have the power to Link Strike, much like you did in Final Fantasy XV *as* Noctis. Noctis was taking a lot of damage for me, so my strategy was to play as a White Mage, turn Garuda away, and heal him as appropriate. This was a lot safer than relying on him to not take damage (but it can be helped by making sure to stack when required, and turning Garuda away).
The key in this fight is to hit the Link Strike button in rhythm with Noct to deal extra damage. If you get off rhythm, it can be hard to get back on it, but it seemed to just work out for me eventually. Every so often, Garuda does a huge almost room-wide AOE attack. Then you just target one of the Monoliths, Warp Strike to it, and you're out of range. This is the easiest time to get back onto the Link Strike rhythm for me because you both go in about the same time. The fight took a little longer as a healer, but not by much. It didn't seem to matter what I was wielding, I did roughly the same amount of damage on Link Strikes. Plus I could Protect/Heal/Regen Prince Noctis. With Garuda dealt with, you receive Prince Noctis' Jacket and Boots. But what about the car?
Completing this quest chain unlocks the "Ironworks Vendor" in a variety of locations, but I focused on the one in the Gold Saucer (in front of the Mini Cactpot Vendor – x5.2, y6.3). From him you can unlock the Regalia Type-G Title (200,000 MGP), Modern Aesthetics – Lucian Locks Hairstyle (20,000 MGP), and the Noctis Lucis Caelum Card for Triple Triad (10,000). Now, I don't really play much in the Gold Saucer, so this was a grind for me. Fortunately, I know people who spend time there and pointed the way for me. Completing the Challenge Logs on a Weekly Basis is a great way to build some MGP, but the biggest bang for your buck is to complete the Weekly Fashion Challenge from Masked Rose (x7.2, y7.4). Completing a brief quest will unlock this weekly challenge for you. This is a pretty easy 60k MGP a week, in most situations. Since it's supposed to be a mystery, the game doesn't tell you what you need. Fortunately, there's a Twitter account that knows more than me, Miss Kaiyoko Star. Miss Kaiyoko Star puts up a list of everything you need to know for the Weekly Fashion Report on their Twitter, so if you don't follow already, go follow (linked below)! Kaiyoko's weekly guides have been a godsend for me. You have until the end of the month, so if you didn't go to the Gold Saucer already, get on that grind!
Miss Kaiyoko Star's Twitter
#Cosmetics
#Mounts
#FFXIV
#MMORPG
#LimitedEvent
Mia Online Announces The Launch of New Servers in May
2017 Gaming Console Predictions - Nintendo Switch
It's that time of the year once again! That time where I, the Dark Prophet, appear to make predictions that will inevitably come true!
by Ragachak
Dragon Awaken Officially Launches from R2Games
R2Games is proud to release a new 3D turn-based Strategy RPG, Dragon Awaken.
Karma Online begins pre-open beta
Brawlhalla Legend Reveal: Barraza
For Honor Season 2: Temple Garden Map Preview
Techland's Titles Begin a Scary Series of Halloween Events


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Brad Pitt read Angelina Jolie's scrip and all he said was "You know, honey, it's not that bad". So it's not that good either.
The information was revealed by Angelina herself who gave an interview for Vanity Fair about penning the script for 'In the Land of Blood and Honey'. When Brad told her the scrips wasn't "that bad" she took it to be encouraging. To us is like saying that thing needs to be redone.
Angelina Jolie: I'm Not Completely Sane!
Angelina Jolie Wants More Children!


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Cambridge College of Healthcare & Technology's mission and commitment to provide our Diagnostic Medical Sonography (DMS) students with access to hands-on, cognitive and affective higher learning opportunities that will develop them to be successful sonographers. With Cambridge's recently created "outstandingly industry modern" ultrasound lab, students are exposed daily to the latest technology which enables them to develop a strong skill level to prepare them for successful job placements.
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It is our firm belief that Cambridge College of Healthcare & Technology's Diagnostic Medical Sonography (DMS) students will reshape health care with a distinction of professional allied health care workers.


text:
National Historical Park New Jersey
Recorded Sound Archive: Search the Catalog and Request a Recording
Cylinder phonograph record storage.
NPS Photo
Search the Catalog:
Thomas Edison National Historical Park's sound archive holdings database is available for public searches on-line, as a part of the National Park Service Library Program's "NPS Voyager" catalog at https://www.library.nps.gov/. Thomas Edison NHP's catalog records in NPS Voyager include MARC-format data for the 11,000 cylinder records and 28,000 disc records preserved at the Edison Laboratory in West Orange, New Jersey. (Thomas Edison NHP's 9800 Edison disc metal molds are not yet cataloged.) The majority of the phonograph records in the catalog are Edison recordings made between 1888 and 1929. The collection also includes some Edison-era recordings released by competing companies.
To limit a search in NPS Voyager to the Thomas Edison NHP records only, follow these steps:
- Go to the NPS Library Information center, on-line at https://www.library.nps.gov/
- Under "NPS Voyager Catalog", click on "search."
- Choose "Basic Search".
- Click on the list titled "Optionally limit to major NPS library."
- Choose Thomas Edison NHP, listed under "Major Park Libraries."
Request an Audio Recording:
Thomas Edison NHP provides digital copies of recordings upon request. Before requesting a recording, we encourage you to search for a copy that is already available via other outlets. Click here for links to Edison-era recordings available on-line from non-profit and governmental organizations. Click here for a list of current compact discs that include recordings from the Thomas Edison NHP sound archive. An on-line discography of Edison records is available here http://www.truesoundtransfers.de/disco.htm.
An individual or group may request one recording per year at no charge. A service fee of $54.00 per hour is charged for requests of more than one recording. The hourly fee will take into account the technical work of reformatting and/or duplicating the audio recording, as well as the additional time needed to fully process the request.
Audio files can be delivered electronically via internet download. Thomas Edison NHP does not supply audio media (CDRs, DVD-Rs, etc.). If needed, audio media must be supplied in advance by the requestor. Use of professional-quality audio media and cover-protection is strongly encouraged.
To begin a request for recordings, please download and print these two forms: "Audio Recording Duplication Request" and "Copyright and Privacy Restrictions". Complete the forms and send them to:
Thomas Edison National Historical Park
Recorded Sound Archive
West Orange, New Jersey 07052
Upon approval of the request forms and receipt of audio media and/or fees, requestors should allow up to 4 to 6 weeks for delivery for large orders. Smaller orders take less time. Rush orders are not accepted. Questions can be addressed to the Museum Curator at the above mailing address, via email or telephone at (973) 736-0550, ext. 48.
Phone are regularly monitored, but in the event that a ranger is unavailable to take your call, please leave us a detailed message with return contact information, and we will be happy to get back to you as soon as we can.


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BMC Pharmacology
Bioequivalence study of three ibuprofen formulations after single dose administration in healthy volunteers
Peter Bramlage1 &
Adrian Goldis2
BMC Pharmacology volume 8, Article number: 18 (2008) Cite this article
This phase I study was designed to determine the bioavailability and bioequivalence of 400 mg Eudorlin® extra* (Ibuprofen) in comparison to two reference formulations (400 mg Nurofen® forte and 400 mg Migränin® after single dose administration under fasting conditions in healthy subjects. Therefore the design of a randomized, open label, multiple sequence cross-over study with a wash-out period of 7–10 days was used.
AUC0-t(last) and AUC0-∞ (90%CI) were within the 80 to 125% interval required for bioequivalence as stipulated in the current regulations of the EMEA. Cmax (90%CI) was within the EMEA acceptance range of 75 to 133%. Detailed analyses showed that Cmax of Eudorlin® extra was higher than that of Nurofen® forte (36.62 vs. 32.92 μg/ml; p = 0.0014) and that of Migränin® (35.94 vs. 30.87 μg/ml; p < 0.0001). The time to maximum plasma concentration (tmax) was shorter with Eudorlin® extra than with Nurofen forte (1.14 vs. 1.82 h; p < 0.0001) and Migränin (1.13 vs. 1.78 h; p = 0.0031). Only 1 patient experienced an adverse with possible relation to the study drug taking Migränin®.
It is concluded that Eudorlin® extra is bioequivalent to the two reference preparations Nurofen® forte and Migränin® for both, the extent and the rate of absorption, after single dose administration in healthy volunteers according to the guidance of the EMEA. Within this frame, peak plasma concentrations are however reached earlier and peaks are higher compared to the reference products.
* Eudorlin ® extra may have different brand names in different countries
Ibuprofen was developed during the 1950s and 1960s as a 'super aspirin' for the treatment of rheumatoid arthritis which was as effective as current alternatives but safer. First synthesised in December 1961 ibuprofen was found to have a short elimination half-life and exceptional gastrointestinal tolerability [1]. Ibuprofen is mostly used today in the management of mild to moderate pain and inflammation in conditions such as dysmenorrhoea, headache including migraine, postoperative pain, dental pain, musculoskeletal and joint disorders such as ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis. It is also used to reduce fever. The usual oral dose in adults is 400 to 800 mg daily for analgesia and up to 1600 to 2400 mg for its anti-inflammatory action [2].
Ibuprofen is absorbed from the gastro-intestinal tract and peak plasma concentrations are reached within about 1 to 2 hours after ingestion. Bioavailability is ≥ 80%. 99% of ibuprofen is bound to plasma proteins, 90% is transformed to 2 inactive metabolites and it has a plasma half-life of about 2 ± 0.5 hours. It is rapidly excreted in the urine mainly as metabolites and their conjugates. About 1% is excreted in urine as unchanged ibuprofen [2].
The European Agency for the Evaluation of Medicinal Products (EMEA) requires generic products that enter the marketplace to show bioequivalence to assess the possibility of alternative use between the reference product and an essentially similar medicinal product [3]. This is done assuming that in the same subject an essentially similar plasma concentration time course will result in essentially similar concentrations at the site of action and thus in an essentially similar effect. Medicinal products authorized and marketed on the basis of a full dossier i.e. including chemical, biological, pharmaceutical, pharmacological-toxicological and clinical data are used as the reference product.
The present study was designed to investigate the bioavailability and the bioequivalence of 400 mg Eudorlin® extra in comparison to two reference products – Migränin® and Nurofen® forte after single oral administration (fasting conditions) in healthy subjects following the EMEA guidance [3]. Two reference products were used since different reference formulations were required in different countries. For this purpose the rate and extent of absorption of ibuprofen under fasting conditions after administration of one tablet of the test product (Eudorlin® extra) and one tablet of each of the reference products were compared in a three sequence cross-over design.
Demography and baseline characteristics
Between February 3rd and March 8th 2007 86 subjects were screened for eligibility of whom 60 were enrolled, randomized and available for pharmacokinetic and safety analyses. 41 of these were male, 19 female. There were three protocol violations (Per-protocol population n = 57). For the first patient the labelling of two blood samples was missing, the other two patients missed at least one visit with missing information for that particular time point. Table 1 displays the patient characteristics of the pharmacokinetic population by treatment sequence. A refers to reference product Nurofen® forte, B to reference product Migränin® and E to test product Eudorlin® extra.
Table 1 Demographic data of subjects
Results of dissolution testing are displayed in Figure 1. Testing was performed for the three products using a total of 504 samples for different time points. All samples resulted in values between 0 and a maximum of 104%. Dissolution was particularly fast with Eudorlin® extra resulting in 99% released ibuprofen within 5 minutes. About the same dissolution was observed after 45 minutes with Nurofen® forte (99%) and 30 minutes using Migränin® (100%).
Results of dissolution testing. Dissolution testing of 400 mg tablets Eudorlin® Extra (Test formulation, in red) versus 400 mg Nurofen® Forte (Reference formulation 1, black) and 400 mg Migränin® (Reference formulation 2, broken black).
Pharmacokinetic
Table 2 displays the pharmacokinetic parameters of the pharmacokinetic (PK) population (n = 60). Table 3 illustrates the statistical analysis. AUC0-t(last) and AUC0-∞ was similar for the comparison of Eudorlin® extra with Nurofen® forte and Eudorlin® extra with Migränin®. All estimates of the ratios for the parameters AUC0-t(last) and AUC0-∞ were near to 1.00 and the 90%-confidence intervals for all comparisons were within the acceptance range of 0.80 – 1.25.
Table 2 Pharmacokinetic parameters
Table 3 Statistical analysis for AUC0-t(last), AUC0-∞ and Cmax
The mean Cmax of ibuprofen differed after Eudorlin® extra compared to Nurofen® forte (36.62 vs. 32.92 μg/ml; p = 0.0014) and after Eudorlin® extra compared to Migränin® (35.94 vs. 30.87 μg/ml; p < 0.0001). The 90%-confidence intervals for both comparisons were however within the widened acceptance range of 0.75 – 1.33 (pre-defined), but also within the standard acceptance range of 0.80 – 1.25.
The tmax varied for Eudorlin® extra between 0.25 to 3.50 hours and after treatment with Nurofen® forte or Migränin® between 0.50 and 5.00 hours (Table 2 displays the mean values ± standard deviation). The difference in tmax of Eudorlin® extra and Nurofen® was statistically significant (1.14 vs. 1.82 h; p < 0.0001) as was the difference between Eudorlin® extra and Migränin® (1.13 vs. 1.78; p = 0.0031).
As an additional variable the elimination half life t1/2 was calculated. The mean elimination half life t1/2 values were similar for all treatments with 2.52 hours after Nurofen® forte, 2.50 hours after Migränin® and slightly higher after Eudorlin® extra with 2.55 or 2.66 hours compared to Migränin® or Nurofen® forte respectively.
The graphic geometric mean time curves for plasma concentration for Eudorlin® extra compared to the reference products – Nurofen® forte and Migränin® were similar with a slightly higher and earlier geometric mean maximum for Eudorlin® extra (see Figures 2 and 3).
Plasma concentration time curve Eudorlin® vs. Nurofen®. Geometric mean time curve for plasma concentration of ibuprofen; cross-over Eudorlin® extra – Nurofen® forte (Pharmacokinetic population; N = 60).
Plasma concentration time curve Eudorlin® vs. Migränin®. Geometric mean time curve for plasma concentration of ibuprofen; cross-over Eudorlin® extra – Migränin® (Pharmacokinetic population; N = 60).
14 subjects of the safety population (N = 60) reported a total of 20 adverse events during the study, 6 of these subjects after treatment with Eudorlin® extra, 6 after Nurofen® forte and 4 after Migränin®. The only adverse event with a possible relation to the study drug was headache reported by 1 subject after intake of Migränin®. 19 were unrelated and 2 unlikely drug related.
The results of this study demonstrate that a single dose of Eudorlin® extra results in similar total systemic exposure (as measured by AUC) compared to Nurofen® forte and after Migränin® throughout a 24 h period. However, the peak plasma concentration (Cmax) was higher and the time to peak plasma concentration (tmax) shorter in comparison to the two reference formulations suggesting a more rapid absorption of the test formulation (for illustration see Figures 2 and 3). These results are consistent with the results of the dissolution testing which suggested a faster release of ibuprofen from the test formulation. All measures are however within the acceptance range of the EMEA bioequivalence guidance [3]. This asks to demonstrate that the 90% confidence interval of AUC0-t(last), AUC0-∞ and Cmax lie within an acceptance range of 80 – 125% while tmax should lie within a clinically determined range but is not further specified.
Acceptance range peak plasma concentration (Cmax)
Ibuprofen has shown to have a low acute and chronic toxicity in a number of clinical studies and registries [2], in particular using the low dose tested. An evaluation of reported side effects after single doses in 15 double-blind randomized trials [4] demonstrated that these were equally distributed across all doses tested. Out of 707 patients 13 (1.8%) reported side effects, 4 of which reported GI-related adverse events. The study protocol considered bioequivalence to be acceptable when the 90% confidence interval was between 75 – 133% based on a large body of bioequivalence studies comparing generic formulations of 400 mg ibuprofen with the reference formulation (Brufen 400 mg in most cases) [5]. Additional file 1 displays the results from these studies, illustrating that the Cmax of generic formulations varies substantially from 28.7 (Motrin® to 43.3 (Ibuprofen 400® Stada).
Cmax values reported for the present study proved to be within the range of the wide (75 – 133%) but as well within the narrow confidence interval (80 – 125%) and are compatible with the other studies conducted [5], including the data of a recently published report by Bienert et al. [6].
Rate and extent of absorption (Cmax and tmax)
A quick release of ibuprofen in the gastrointestinal tract following oral administration is desirable [7] to achieve rapid pain relief and to avoid overdosing due to multiple ingestions based on a prolonged onset of action. As serum concentrations of ibuprofen and its analgesic effect are highly correlated, rapid ibuprofen absorption is the sole prerequisite for the quick onset of its action. Because its membrane permeability approaches up to 100% dissolution of the tablet becomes the rate limiting step for absorption [8]. A more rapid pain relief could translate in higher patient satisfaction and less danger of repeated ibuprofen intake due to slow onset of action.
It has been shown in the present study that Eudorlin® extra tablets are rapidly dissolved in vitro resulting in 99% dissolution after only 5 minutes. In comparison it took 30 and 45 min respectively for the two reference formulations to achieve a similar degree of dissolution. This observation is compatible with the faster (tmax) and higher peak plasma concentration (Cmax) observed in the present cross-over study in healthy volunteers. The values obtained did on the other hand not trespass the predefined acceptance range for Cmax as outlines above, thus not questioning the assumption of bioequivalence.
Statistical analyses of primary parameters provided evidence for the therapeutic equivalence of the three ibuprofen formulations: the 90%-confidence intervals for the comparison Eudorlin® extra/Nurofen® forte and Eudorlin® extra/Migränin® were within the predefined acceptance range of 0.80 – 1.25 for both, AUC0-t(last) and AUC0-∞ and within the acceptance range of 0.75 – 1.33 for the parameter Cmax. Peak plasma concentration was however higher and the time to peak plasma concentration shorter, compatible with a more rapid pain relief with Eudorlin® extra. All three formulations were well tolerated. The only adverse event with a possible relation to the study drug was reported by one subject after Migränin® exposure.
Study design and inclusion criteria
This phase I study (study code 398B6) was a single-dose, randomized, open label, three-treatment, three-period, three-sequence cross-over with a wash-out period of 7–10 days. Patients were eligible for inclusion if they were male or female of Caucasian origin, between 18 and 55 years of age, a body mass index (BMI) of between 19 and 28 kg/m2 and had provided written informed consent prior to study participation. Women of childbearing age had to be negative on a pregnancy test and had to agree to be either sexually inactive for 30 days prior to study participation or use an appropriate method of contraception.
Film coated tablets of ibuprofen (Eudorlin® extra for oral administration, batch number 62020, expiry date 05/2009) were tested against two reference formulations of ibuprofen: Nurofen® forte (Ibuprofen 400 mg coated tablets, batch number 13J, expiry date 06/2009 and Migränin® (Ibuprofen 400 mg coated tablets, batch number 12J, expiry date 06/2008). Dissolution testing was performed at pharm-analyt Labor GmbH, Baden, Austria between February 23rd and March 15th 2007 using a HPLC-UV technique.
A three sequence cross-over design, allowed for the comparison of different subject sequences: 1) Subjects who received Nurofen® forte (A) during periods 1 and 2 compared to subjects who received Eudorlin® extra (E) during these periods (1 and 2) (sequence AE/EA); 2) Subjects who received Migränin® (B) during period 2 and 3 compared to subjects who received Eudorlin® extra (E) during these periods (2 and 3) (sequence EB/BE). The study consisted of three treatment phases separated by wash-out periods of 7 to 10 days (Figure 4). At least 12 h before each treatment period the subjects were admitted to the site. After an overnight fasting of at least 10 h subjects were administered 400 mg ibuprofen in sitting position between 8 and 9 a.m. (time point 0). Blood samples (6 ml each) were collected from all subjects 12 min prior to dosing and at 0.25, 0.5, 0.75, 1.0, 1.25, 1.5, 1.75, 2.0, 2.5, 3.0, 3.5, 4.0, 5.0, 6.0, 8.0, 10.0, 12.0, 16.0 and 24.0 hours after drug administration. Patients were observed for a total of 36 h (12 h prior until 24 h after drug administration). The blood samples were collected in heparinised tubes and cooled immediately in an ice bath and centrifuged at 3500 r.p.m. under refrigeration to obtain plasma. Immediately after centrifugation the plasma was homogenized, the tubes capped and stored frozen at -20°C.
Allocation of subjects to the appropriate sequence groups during the study. S: Sequence groups; A: subjects receiving drug A (Nurofen® forte), B: subjects receiving drug B (Migränin®, E: subjects receiving Eudorlin® extra.
Personal data, medical history, physical examinations (height, weight, 12-lead ECG), vital signs (blood pressure, heart rate, temperature) and laboratory tests were obtained during the screening phase. During each treatment period, vital signs and adverse events were recorded. Clinical safety parameters included a general medical examination, heart rate and blood pressure (sitting position) and the documentation of adverse events. Clinical laboratory safety was assessed with clinical chemistry, haematology, urinalysis, pregnancy test, HIV, HbsAg and HCV screening, urine drug screening and an alcohol breath test. Within a 7 day time frame after last blood sampling an ECG, clinical laboratory parameters and physical examination were repeated.
Analytical method and chromatographic system
Determination was conducted considering GLP-guidelines [9]. Procedure of validation and acceptance criteria were based on the rules and guidelines of the FDA [10] and of the ICH Consensus Guidelines. Pre-study validation of the method was performed by documentation of specificity, linearity, limit of quantification, precision and accuracy. Furthermore recovery rate and stability of ibuprofen in plasma samples were investigated. For in-study validation each run contained samples for the calculation of standard curves; quality control samples and the samples of the subjects. The run was accepted, if no more than two of six quality control samples were outside ± 15% from the nominal value.
Determination of ibuprofen was performed using HPLC method with fluorescence detection [11]. A Merck-Hitachi L-7485 was used for detection of ibuprofen (excitation 225 nm, emission 290 nm). Chromatographic separation was carries out using a Luna 5 μC18(2) 100A, 50 × 2.0 mm (Phenomenex, USA). The mobile phase was 35% 0.02 molar phosphoric acid: 65% MeOH (v/v). The flow rate was 1.0 ml/min.
A sample volume of 250 μl was analyzed and a volume of 10 μl injected onto the chromatographic column. The method was validated between 0.200 and 75.0 μg/ml. In this study the retention time was 1.5 min. The blank sample showed no peaks in the retention time window of interest.
The assay showed an acceptable linearity over a concentration range from 0.200 to 75.0 μg/ml (r ≥ 0.99, n = 8). The limit of detection defined as baseline noise was 0.206 μg/l. Specificity: There were no interfering peaks for the endogenous compound for the blank plasma at the retention time of ibuprofen (1.5 min.). The inter-batch precision was between 9.96% for 0.500 μg/ml and 6.35% for 63.8 μg/ml. The within-batch precision was between 1.56% for 0.206 μg/ml and 5.83% for 75.0 μg/ml. The accuracy (bias) for ibuprofen was expressed as a percent deviation of observed plasma concentration from theoretical concentration (0.5, 5.51 and 63.8 μg/ml). The accuracy ranged from 1.3% (0.500 μg/ml) to 4.5% (5.51 μg/ml). For the determination of recovery peak areas determined following analysis of calibration standards with concentrations of 0.5, 5.51 and 63.8 μg/ml were compared with data obtained by direct injection of aqueous solutions of these concentrations. The mean recovery of ibuprofen from spiked plasma samples was on average 92.2%.
Sample size was based on a intra-individual CV of 26% based on a previous bioavailability study of Eudorlin® extra (Clinical trial report BCBe/02/Ibu-BV-001) and data from Blume and Mutschler [5]. For a total of 36 subjects (2 × 18) the power to detect bioequivalence was 96% assuming a true ratio of 0.95, and 98% assuming a true ratio of 1.05 (calculations based on equivalence limits of 0.75 and 1.33). As bioequivalence had to be shown with 2 reference products sample size was adjusted to 3 × 18 (54) subjects. Therefore 60 patients were included to allow a drop-out of 10% (6 subjects).
The statistical analyses were performed by using SAS 8.2 [12]. The primary pharmacokinetic parameters after logarithmic transformation (multiplicative model) were subjected to an analysis of variance (ANOVA) with the factors SEQUENCE, SUBJECT nested within SEQUENCE, PERIOD and FORM (drug formulation) using a general linear model procedure. For assessment of bioequivalence 90%-confidence intervals for the formulation ratio in the parameters AUCt (calculated using the trapezoidal rule), AUC∞ (calculated as sum of AUCt and the extrapolated area using the last measured concentration [C(last)] and the elimination half life by taking the formula: [C(last) × t1/2/ln2]), and Cmax (directly obtained from measured values) of ibuprofen were calculated using the ln-transformed data. Bioequivalence was accepted if the calculated 90%-confidence intervals were within 0.80 – 1.25 for AUCt and within 0.75 – 1.33 for Cmax. Possible side effects of the study medication and any adverse events were listed. Time of maximum plasma concentration (tmax) was directly obtained from measured values and compared using the two samples Wilcoxon test. Elimination half life (t1/2) was calculated from concentrations of the elimination phase using semi-log transformed data and linear regression was documented individually.
The story of ibuprofen. [http://www.ibuprofen-foundation.com/]
Frölich JC, Fricker RM: [Pain therapy and analgetics-antipyretics (Nonsteroidal antirheumatic drugs – NSAR)]. Praktische Arzneitherapie. Edited by: Frölich JC, Kirch W. 2006, Heidelberg: Springer, 675-706. 4
Note for Guidance on the Investigation Bioavailability and Bioequivalence (CPMP/EWP/QWP/1401/98).
Furey SA, Waksman JA, Dash BH: Nonprescription ibuprofen: side effect profile. Pharmacotherapy. 1992, 12 (5): 403-407.
Blume H, Mutschler E: Bioäquivalenz, Qualitätsbewertung wirkstoffgleicher Fertigarzneimittel. 1996, Frankfurt/Main – Eschborn: Govi-Verlag Pharmazeutischer Verlag
Bienert A, Szkutnik-Fiedler D, Dyderski S, Grzeskowiak E, Drobnik L, Wolc A, Slawiniska U: Comparative bioavailability study of two ibuprofen preparations after oral administration in healthy volunteers. Arzneimittel-Forschung. 2006, 56 (9): 647-651.
Laska EM, Sunshine A, Marrero I, Olson N, Siegel C, McCormick N: The correlation between blood levels of ibuprofen and clinical analgesic response. Clin Pharmacol Ther. 1986, 40 (1): 1-7.
Newa M, Bhandari KH, Kim JO, Im JS, Kim JA, Yoo BK, Woo JS, Choi HG, Yong CS: Enhancement of solubility, dissolution and bioavailability of ibuprofen in solid dispersion systems. Chem Pharm Bull (Tokyo). 2008, 56 (4): 569-574.
GLP: Principles of Good Laboratory Practice as specified by national (German Chemicals Law, Annex 1, 20 June 2002) and international (OECD, Paris, 1998; EC Directive 2004/10/EC, 11. February 2004).
U.S. Department of Health and Human Services Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Veterinary Medicine (CVM). Guidance for Industry Bioanalytical Method Validation. [http://www.fda.gov/cder/guidance/index.htm]
Sochor J, Klimes J, Sedlacek J, Zahradnicek M: Determination of ibuprofen in erythrocytes and plasma by high performance liquid chromatography. J Pharm Biomed Anal. 1995, 13 (7): 899-903.
SAS8.2: SAS® software. Release 8.2 edition. 2001, Cary NC: SAS Institute Inc
The study was sponsored by Berlin-Chemie AG, Berlin, Germany and conducted by IFE Human Pharmacology SRL in Timisoara, Romania. Dissolution testing was done by pharm-analyt Labor GmbH, Baden, Austria.
Institute for Clinical Pharmacology, Medical Faculty Carl Gustav Carus, Technical University Dresden, Fiedlerstrasse 27, 01307, Dresden, Germany
Peter Bramlage
IFE Human Pharmacology SRL, Str. Cornelia Salceanu Nr. 5, 300561, Timisoara, Romania
Adrian Goldis
Search for Peter Bramlage in:
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Correspondence to Peter Bramlage.
AG was the principal investigator at IFE Human Pharmacology SRL and was responsible for planning and conducting the study. PB drafted the manuscript. All authors read and approved the final manuscript.
Additional file 1:Cmax values from various bioequivalence studies(DOC 52 KB)
Bramlage, P., Goldis, A. Bioequivalence study of three ibuprofen formulations after single dose administration in healthy volunteers. BMC Pharmacol 8, 18 (2008) doi:10.1186/1471-2210-8-18
DOI: https://doi.org/10.1186/1471-2210-8-18
Reference Product
Single Dose Administration


text:
Medicine River steht für:

 Medicine River (Red Deer River), Nebenfluss zum Red Deer River in Alberta, Kanada
 Medicine River, anderer Name des Sun River in Montana, Kanada
 Medicine River (Roman), Roman von Thomas King (1990)
 Medicine River (Film), kanadischer Fernsehfilm von Stuart Margolin (1993)

Siehe auch:
 Yellow Medicine River, Zufluss zum Minnesota River in Minnesota, Vereinigte Staaten
 Medicine Lodge River, Zufluss zum Salt Fork Arkansas River in Kansas und Oklahoma, Vereinigte Staaten


text:
LiquidityBook Taps Isaac Cambron to Lead Research and Development Efforts
NEW YORK – September 20, 2022 – LiquidityBook, a leading provider of cloud-native trading solutions for the buy and sell sides, today announced the hire of Isaac Cambron as Vice President of Research and Development. Reporting directly to Chief Technology Officer Shawn Samuel, he will spearhead enhancement efforts for the firm's robust suite of trade management offerings.
In this role, Mr. Cambron will act as a senior product development leader for LiquidityBook's expansive client base, working to meet its unique demands and challenges by translating preferences and pain points into new system features and updates. By working to identify critical needs in the market, he will play a key role in determining the overall direction of the LiquidityBook platform.
Mr. Cambron brings an extensive background in engineering and product development. He most recently served as Vice President, Engineering for Seismic – a cloud-based global sales enablement platform – where he led a sizable research and development team in building game-changing capabilities in a wide range of areas, including deep analytics, API-based functionality and artificial intelligence/machine learning, in addition to other innovative applications and features.
Commenting on Mr. Cambron's hire, Mr. Samuel said: "The strategic addition of Isaac to our team reflects our ongoing commitment to serving as true partners to our clients. We recognize that to thrive in today's markets, firms need tools that offer robust functionality while providing a tailored experience that meets their precise requirements. By making this key investment in our research and development efforts, we are now better positioned than ever to offer the robust products and industry-leading service that clients have come to expect from LiquidityBook."
Mr. Cambron said: "LiquidityBook has a strong team, a powerful platform and a growing reputation. I am excited to help build the next generation of trade management tools, and I look forward to joining this innovative group of individuals as we work to take our current product and service offerings to the next level."
This key hire comes during a period of significant growth for LiquidityBook, which has added several senior personnel to its team over the past year, including Jonathan Cross as General Manager, EMEA. The firm has further expanded and enhanced its offerings in recent months, including via strategic agreements with Clearwater Analytics and S3 Partners.
LiquidityBook is a leading provider of cloud-native buy- and sell-side trading solutions and is trusted by many of the industry's largest and most sophisticated firms. The LiquidityBook platform is easily configurable and enhanced daily with client requests, giving these firms peace of mind that their trading platform will adapt and scale as they grow. A disruptive force in the market for over 15 years, the founder-led LiquidityBook backs their platform with unparalleled support and employs a client-centric business model with no hidden fees. For more information, please visit www.liquiditybook.com or contact sales@dck.kas.mybluehost.me.
CJ Lengua
clengua@forefrontcomms.com
PrevPreviousBuy AND Build: How LiquidityBook Answers an Age-Old Technology Question Through Powerful Technology and Flexible Integration
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Baicham est une localité du Cameroun, située dans l'arrondissement de Belo, le département du Boyo et la région du Nord-Ouest. C'est l'un des 29 villages de la commune de Belo créée en 1993 (Belo Rural Council, à l'origine).

Environnement
À une altitude de , Baicham se trouve sur les hauts-plateaux (Kom Highlands), dans un environnement naturel de collines et de forêts, où l'agriculture constitue la principale activité.

Géographie humaine
Baicham fait partie du pays Kom. Cependant « kom » est devenu le terme générique désignant plusieurs chefferies indépendantes  – telles que Achain, Akeh, Ajung, Mbengkas, Mbesinaku, Mbueni, Baicham, Baiso et Menjang – conquises par les Kom, le plus souvent sous le règne de Foyn Yuh (1865-1912). La plupart de ces petites chefferies vassales comptaient moins de 400 personnes.

Le chef du village de Baicham se trouve sous l'autorité du fon de Kom, Vincent Yuh II, en place depuis 1994.

On y parle le baicham, un dialecte du kom, une langue des Grassfields du groupe Ring.

Lors du recensement de 2005, on a dénombré 299 habitants à Baicham.

Notes et références

Annexes

Bibliographie
  Paul Nchoji Nkwi, Traditional government and social change : a study of the political institutions among the Kom of the Cameroon Grassfields, University Press, Fribourg, 1976, 233 p.  (thèse)

Liens externes
  Belo, sur le site Communes et villes unies du Cameroun (CVUC)
  Belo Council Development Plan, PNDP, 2011 ?, 134 p.

Village dans la région du Nord-Ouest (Cameroun)


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Devon, również Devin lub Devin Striker, właśc. Kristie Marie Lisa (ur. 28 marca 1977 w Allentown) – amerykańska aktorka filmów porno pochodzenia holenderskiego, francuskiego, angielskiego i Czirokezów. Bomis Babe Report uznał Devon za jedną z najbardziej pociągających kobiet w przemyśle filmów pornograficznych. Często określana jako "Jenna Jameson, Jr".

Życiorys

Wczesne lata
Urodziła się w Allentown w Pensylwanii. Devon uprawiała gimnastykę do piętnastego roku życia. Uczęszczała do Emmaus High School. Po skończeniu nauki w szkole średniej została kelnerką. Wzięła udział w przesłuchaniu na "amatorską noc" w kabarecie Ala Diamonda, a później uzyskała pierwsze miejsce. Przez trzy lata tańczyła w kabarecie Ala Diamonda.

Kariera
Przed przyjazdem do Kalifornii podjęła pracę jako egzotyczna tancerka. Wkrótce została fotomodelką, pozując do kilku męskich magazynów takich jak "Penthouse" i "Club International". Pierwsze zetknięcie Devon z przemysłem pornograficznym nastąpiło w Pleasure Productions New Breed (1998). Po krótkim czasie podpisała kontrakt na wyłączność z firmą Vivid Video.

Wystąpiła m.in. w Three (1999) z Inari Vachs, Blondage 3 (1999) w reżyserii Paula Thomasa z Julianem, Where the Boys Aren't 12 (2000) z Janine Lindemulder, Nice Neighbors (2001) z Markiem Davisem, Perfect Pink 10: In Hawaii (2001) z Jill Kelly, Piraci (Pirates, 2005) jako Madelyn z Evanem Stone'em.

W 1999 Devon wystąpiła w programie Howarda Sterna E! Entertainments.

W styczniu 2001 została ulubienicą magazynu "Penthouse".

W styczniu 2002 dostała pierwszą nagrodę w swojej karierze w kategorii "Najlepsze interaktywne DVD" za produkcję Virtual Sex with Devon (2001), która również później była nagrodzona przez Empire i AFW.

Firma Digital Playground podpisała z Devon kontrakt na wyłączność.

W maju 2002 była na rozkładówce magazynu "Stuff".

W 2013 roku otrzymała nominację do XRCO Award w kategorii "Najlepszy powrót" (Best Cumback).

Wystąpiła także w filmie dokumentalnym Nathana S. Garfinkela Fluffy Cumsalot, Porn Star (2003) oraz komediodramacie Don Jon (2013) z udziałem Josepha Gordona-Levitta, Scarlett Johansson, Julianne Moore, Anne Hathaway i Channinga Tatuma.

Nagrody i nominacje

Przypisy

Amerykańskie aktorki pornograficzne
Amerykanie pochodzenia holenderskiego
Amerykanie pochodzenia francuskiego
Ludzie urodzeni w Allentown (Pensylwania)
Urodzeni w 1977


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Leftists Who Loathe Whites & Conservatives Are What Is Bringing America Down
Written by: Jesse Lee Peterson
White people are under attack in this country like never before. Whites are the only people who, as a whole, are creating and not destroying, who believe in our American freedoms and don't vote them away. Whites are the ones standing in the way of socialism and the insanity of the left. Weak people have taken control of most of the government, media and "educational" institutions, to slander good and uplift evil. Fake media, Democrats, RINO Republicans and Never Trumpers pretend to care about so-called "people of color," women and other false victim groups, while attacking decent whites.
The children of the lie hate God, men, Christians and whites. They want to kill the unborn child. They push false "love" and "tolerance" for homosexuals and transgenders, preventing them from overcoming their issues. They support illegal aliens destroying their souls and their children by abandoning their countries to invade ours. Democrats tempt and corrupt people by offering free stuff, robbing them of the ability to build their own character, independence and life. It's all for "power" and wealth – to advance their egotistical ideology. They weaken and replace men, whites and Christians. Then they seduce and corrupt women and children.
We saw the attack on gun rights, on President Trump and white people after the New Zealand mosque attacks. The murders were allegedly by an angry environmentalist one-time communist who hated immigrants for contributing to so-called "overpopulation." One thing the alleged shooter Brenton Tarrant was right about: white people are not having babies. I have been calling on white people to have more white babies. If we lose white people, we lose America. But the people of color are brainwashed to hate and blame white people for everything wrong in "history" and in their own lives.
On the rare occasion that a white person attacks back in the wrong way, media and politicians fear-monger about imaginary white "racism." They take away innocent people's freedom of speech and ability to defend themselves. We saw it with Dylann Roof's Charleston church shooting, with the fake news propaganda on the Charlottesville Antifa riot, and in New Zealand last week. Because of the attack on white men – and due to fear of speaking up – whites are becoming angry, just like the people of color. Resentful of the injustice against them, young white men are becoming what they hate.
You're supposed to see injustice and speak out against it, but don't hate injustice. For decades, whites decided to stay silent about out-of-control behavior, violence and hatred by black Americans and others – for fear of being called racist. Utterly shut off from truth and correction, and being spoiled and catered to, blacks have only gotten worse Their false leaders are a joke, their churches anything but Christian, their so-called "families" non-existent, and their communities devoid of real men. The light is gone, and they're ripe for exploitation and brainwashing by evil.
As an example of a "Christian" in the black community, take Arkansas State Sen. Stephanie Flowers, a black Democrat. This woman is pro-abortion, anti-Second Amendment and hates white men. Yet she invokes "Christ" in shameless hypocrisy. Black "Christians" vote people like her into power around the country. Just look at Maxine Waters, Sheila Jackson Lee, Frederica Wilson and too many others. As it was with Barack Obama, they're not qualified – they're just black (and they support evil).
Earlier this month Sen. Flowers made a horrible scene at a hearing on a "Stand Your Ground" bill. She screamed, cursed and carried on like she was demon-possessed. She portrayed blacks as victims of gun rights, not black-on-black violence. She didn't tell the truth that blacks are robbing, attacking and killing whites and other blacks. She mocked and derided responsible gun owners for exercising their rights. When white Republican State Sen. Alan Clark spoke up softly to calm her down, she cursed at him and shouted, "Go to hell!"
Afterward, she refused to apologize, claiming she has Jesus in her heart, that she's "a follower of Christ Jesus," that "God" is her judge, and hopes "He's well pleased." Satan is her daddy, and he is well pleased!
It's angry black mothers like this who are traumatizing black boys and girls. These black women do not love their fathers, so they spread violence and mental illness in the black community – all in name of "Jesus"!
Unsurprisingly, far-left media outlet "Now This," a propaganda organization founded by former heads of Huffington Post, promoted State Sen. Flowers' behavior. In a flashy, heavily edited social media video they put dramatic music to her hissy fit. They gave cherry-picked information about whites going "free" after killing blacks. They leave out whether these were self-defense killings. They ignore that blacks kill more than twice as many whites as vice versa every year, per FBI stats.
Christians and whites are attacked and killed even in their own countries. But nothing is said. People of color are allowed to turn them into "s***hole countries."
If we lose our freedom here in America, is there anywhere else to go?
Order Rev. Jesse Lee Peterson's book, "The Antidote: Healing America from the Poison of Hate, Blame, and Victimhood."
Article posted with permission from Jesse Lee Peterson
Supreme Court Did Not Make Abortion The Law Of The Land – They Made Murdering Babies For Money The Lawlessness Of The Land Next Post:
This is About the Muslims Attacking You! – Part 1
About the Author: Jesse Lee Peterson
Rev. Jesse Lee Peterson is the founder and president of two dynamic organizations: BOND (Brotherhood Organization Of A New Destiny), a national 501(c) (3) nonprofit organization dedicated to "Rebuilding the Family by Rebuilding the Man," and BOND Action, a 501(c) (4) organization whose purpose is to educate, motivate and rally Americans – especially black Americans – to greater involvement in the moral, cultural and political issues that threaten our great country. In 2011, Jesse founded The South Central L.A. Tea Party. He's a media commentator and also hosts "The Jesse Lee Peterson Radio Show" M-F, 6-9 a.m. Pacific, 9-Noon Eastern (weekend show airs every Saturday on AM 870 "The Answer," 2-3 p.m. PST/5-6 p.m. EST), and is the author of "SCAM: How the Black Leadership Exploits Black America." For more information, visit www.bondinfo.org or www.bondaction.org. Also, check out the BOND LEADERSHIP ACADEMY, a school for boys and girls grades 1-12 at www.bondleadershipacademy.org.


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Трострука круна глуме израз је који се користи у америчкој индустрији забаве за глумце и глумице који су током своје каријере успели да освоје награде Оскар, Еми и Тони у глумачким категоријама. Ове три награде представљају највиша достигнућа у области америчког филма, телевизије и позоришта, респективно. До данашњег дана, само 24 особе (15 жена и 9 мушкараца) успеле су да остваре ово достигнуће.

Дана 5. фебруара 1953, Хелен Хејз је освојила Награду Ејми и тиме постала прва којој је ово пошло за руком. Непуна два месеца касније, Томас Мичел је својој колекцији додао и Награду Тони, чиме је постао први мушкарац са Троструком круном. Хејз и Рита Морено су једине добитнице Троструке круне које су поред тога успеле да освоје и Награду Греми. Дама Меги Смит је, са два Оскара, четири Емија и једним Тонијем, тренутна рекордерка по броју освојених награда у категорији Троструке круне.

Освајачи Троструке круне који су тренутно живи су: Рита Морено, Џереми Ајронс, Ванеса Редгрејв, Меги Смит, Хелен Мирен, Џефри Раш, Ал Паћино, Франсес Макдорманд, Џесика Ланг, Елен Берстин, Гленда Џексон и Вајола Дејвис.

У британској индустрији забаве исти израз се користи за глумце и глумице који су освојили Филмску награду БАФТА, Телевизијску награду БАФТА и награду Лоренс Оливије (за позориште). Убедљива рекордерка по броју освојених британских Троструких круна је Џуди Денч, којој недостаје само Еми, како би комплетирала и америчку.

Преглед добитника
 Године наведене у колонама Оскар, Еми и Тони су године у којима су глумци по први пут освојили те награде
 За награде Еми и Томи, то је година церемоније, а за Оскара, година када је филм премијерно приказан.
 У колони укупно награда урачунате су само награде Оскар, Еми и Тони.

Види још
 Оскар
 Награде Еми
 Награде Тони

Референце

Добитници награде Оскар
Добитници награде Еми
Добитници награде Тони


text:
Home / Cars / New Peugeot 208 2019 prototype review
New Peugeot 208 2019 prototype review
Alex Ward 1 week ago	Cars Leave a comment 13 Views
12 Jul, 2019 4:30pm Vicky Parrott
We get behind the wheel of the new Peugeot 208 in prototype form to see if it can drive as well as it looks…
The Peugeot 208 doesn't need much introduction. It's the bread and butter of the small car world, along with key rivals like the Vauxhall Corsa (which now shares its platform and powertrains with this all-new 208) and Ford Fiesta.
Peugeot is pitching itself as 'the classy one' in this rather crowded corner of the market. The chunky but chic styling certainly backs that up, as does a rather executive-looking interior that borrows much of its styling from the Peugeot 508.
• Best superminis to buy
The 208 is also going to bring electric motoring into the mainstream like never before, since it is offered in pure electric guise with a 211-mile driving range.
Here, we're driving a prototype version of the 1.2-litre turbocharged petrol; the mid-level option in a line-up of three petrol engines that also include a 74bhp version of this engine, and a more powerful 128bhp version that comes with an eight-speed automatic gearbox as standard. A 98bhp diesel is also on offer.
Our time in the prototype version of the six-speed manual PureTech 100 backs up the on-paper figures that suggest this is the sweet spot in the range if you don't fancy that electric version.
The engine needs to be revved quite a bit to get the best out of it, but it's happy to thrum away cheerfully and is both quiet enough and pokey enough to do a great job of both town or motorway travel. The clutch action is vague in our car, and the gearknob is an unnecessarily large, squared-off affair that makes it feel like you're changing gear with your wallet. But despite all that it's not difficult to drive the 208 smoothly and with a bit of vigour.
Select Eco mode via the toggle switch under your elbow and the steering becomes overly light, but Normal weights things up and delivers more reassuring bite as you swing into a corner. At that point you'll also find the 208's neutral cornering style is absolutely fit for purpose, but a lot more flat-footed than the always entertaining Fiesta, or even the sharper SEAT Ibiza.
Don't be misled by the Peugeot marketing, then, which will shout about driving excitement and 'unboring' the future. The 208 is a car that majors on comfort, refinement and a classy finish. It soaks up small bumps easily, delivering a loose, spongey ride comfort that'll sure to make light work of scruffy town roads. The compromise is some body lean even at low-speed cornering.
The main thing that characterises our 208 (which may yet be a fraction off the final production set-up) is just how grown up it feels. It doesn't feel like a small, affordable car so much as a truncated executive car.
That's in part thanks to the unruffled way it goes down the road, but it's even more thanks to the interior. Some drivers will have to play around with the seat adjustment to find a position that allows them to see the dials clearly over the top of the small steering wheel, but the dense materials and variety of finishes in our Allure test car make it feel really classy.
There's even a driver readout with '3D' look, thanks to select information being beamed onto a reflective screen. It looks a weird initially, but within a few minutes, your eyes get used to the fact that the digital speed readout appears to be jumping out of the dials.
Overall, the minimalist design and tactile materials make the 208 feel great inside, and while final details are yet to be confirmed you can expect the 208 to be one of the better-equipped options in this class – even in its cheapest guise, which is expected to cost from around £16,000.
It's good for practicality, too. The new 208 is a five-door only, and while the rear door aperture is a little narrow, once you've slid onto the rear seats there's room for two adults to get comfortable.
A 311-litre boot makes for plenty of space to throw a chunky buggy or a Labrador (maybe not both together), although it's a shame that there's no variable boot floor to create underfloor storage and a flush load lip.
Still, you can add a space-saver tyre without impacting on boot space, and other standard safety equipment includes traffic sign recognition and autonomous emergency braking, while blind-spot recognition and a semi-autonomous driving mode will be standard on higher-spec cars.
The new 208 is set to take the title of the most grown-up small car on sale – set apart by a classy interior and plush ride. It's not exciting to drive, but if loads of tech and a premium feel is what you're after, the Peugeot should be on your list.
Model: Peugeot 208 1.2 PureTech 100 Allure
Price: £18,000 (est)
Engine: 1.2-litre 3cyl turbo petrol
Power/torque: 98bhp/200Nm (est)
Transmission: Six-speed manual, front-wheel drive
0-62mph: 9.5 seconds (est)
Top speed: 115 mph (est)
Economy: 50mpg (est)/ 99g/km (est)
On sale: Winter 2019
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Truckloads of counterfeit cartridges seized in Russia
Raid by Russian law enforcement results in seizure of three truckloads of fake HP cartridges.
Russian radio website Radiovesti reports that the largest raid conducted against counterfeiters in Russia in two years was carried out in December 2012, and resulted in the seizure of more than four thousand counterfeit printer cartridges claiming to be HP products.
Three truckloads of illegal products were seized during the raid, which took place at production and storage facilities in a closed research institute, where counterfeit goods were packed in second-hand original packaging ready for selling. All packaging was also confiscated by the law enforcement authorities.
The case saw the biggest number of cartridges seized in a raid in Russia for two years, with another similar raid in February uncovering 2,500 counterfeit HP-branded cartridges.
According to the article, Colonel Konstantin Grakhovo, Deputy Chief of customs control after the release of the goods from Moscow customs, commented that the agency is "committed to pursue and bring to justice the manufacturers of counterfeit products which contain unknown chemicals that damage the printer, capable of inflicting damage to the environment", adding that the seizure of the products is likely to lead to further anti-counterfeiting activities in the region.
Despite the raids, the article notes that according to research by Forrester Consulting, Russia was found to have one of the lowest levels of counterfeit HP cartridges in the EMEA region, with around 11 percent of organisations indicating that they had encountered counterfeit cartridges compared to 23 percent of organisations in the UAE, 31 percent in Algeria and 50 percent in Nigeria.
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Tags : Counterfeiting Crime Russia