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TV show Billions all seasons download
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Created By: Brian Koppelman, David Levien, Andrew Ross Sorkin
Toby Leonard Moore
David Costabile
Condola Rashad
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Billions season 4 download
There are many television series in the world that talk about the rich. Have you ever watched a show about their opposition? On the conflict of two fairly well-known personalities tell the television series "Billionaires." This film is based on the script of David Levin and Brian Koppelman.
They wrote the script for such famous films as "Ocean's 13", "Rounders", "Call Girl". The plot is very unusual. Here the interests of two influential people will clash.
One is Chuck Rhoads lawyer. He is a prosecutor, known for his principles. And the second, Bobby Axelrod, is a financier. He is the king among his peers. The risk is common for him, and luck always smiles on him.
Here you can download "Billions" TV series
Please follow the links on this page to download all "Billions" seasons and episodes
Billions season 4
The modern world is terribly confused. It is unclear exactly who controls what is happening. Politicians hold power, businessmen have a lot of money, economies and marketers do not allow the market to fall into oblivion. All these people have solid influence and big money, which sometimes turn out to be above the law.
The focus of the plot project "Billions" are two characters, each of which defends its truth. Bobby Axelrod is engaged in a successful business and receives a solid profit. After the financial crisis, he became one of the few who somehow managed to stay in business. The situation is completely different with Prosecutor Chuck Rhoads.
He knows very well that after such a global financial collapse, no one would be able to calmly get back to business. Chuck is sure that Axelrod's shadow policy brings a lot of money to the owner, but is, of course, illegal.
A serious conflict flares up between big people, whose scale grows beyond the boundaries of personal and professional enmity. Chuck is looking for compromising materials, puts his own conditions, drives Axelrod to a standstill, but huge amounts of money appear in their disassemblies, which will now be very difficult to disown.
Trailer Billions season 4
Scenes Billions season 4
In the 3rd season of Billions we can clearly understand, that the modern world is an unpredictable substance. Nobody knows who controls and whi is under control. The focus of the plot of this season is the confrontation between two outstanding personalities. The action takes place in New York.
We can watch the clash between Chuck Rhodes – the local prosecutor with an iron character, powerful and tempered willpower, and Bobby Axelrod – a genius who hopes to succeed in a planned financial scam.
In the 3rd season of Billions Bobby makes very dubious and suspicious investments that draw Chuck's attention. He tries to figure out Axelrod, but it is not very easy for him, because his opponent is very clever and cunning, he can find a way out of any difficult situation and always try to be unnoticed. Will he be able to do it? We can learn it soon in the long-awaited season
There is a real impersonation of the opposition of politics and business in the third part of Billions. Are you ready to enjoy this confrontation just now? Sit back comfortably and watch it! This season promises to be really outstanding and incredible, but also unpredictable as the previous two seasons of Billions.
Billions - Season 4 episodes free download.
Download all third season episodes of "Billions" for all devices (desktop/mobile)
The action of the film "Billions" takes place in New York, a city that is famous for huge capital and all sorts of possibilities. It is not a secret to anyone that it is impossible to earn millions just by honest labor. Only those who skillfully perform various kinds of machinations and withstand the toughest competition can reach such heights in the business world.
Bobby Axelrod is a rich man on Wall Street. This person has billions of dollars in his accounts, which he increases daily. He did not always accumulate his capital in an honest, lawful way. He had to clean up competitors and cross the law. But at the same time, Bobby very often does charity events, a huge amount invests on the needs of the city.
The prosecutor Chuck Rhodes knows this, but he still wants to put a sighted billionaire behind bars.
Maybe the prosecutor would have already started his hunt a long time ago, but the fact that his wife Wendy works for one of Axelrod's firms stops him. But he does not intend to give up his words.
He always tries to get as close as possible to the billionaire, but he has the unique ability to see his future and therefore always turns out to be ahead of the guardian of the law.
And again, men engage in battle with each other. If the first for the sake of promotion in the service, then the second protects the acquired wealth.
The modern world is an unpredictable substance. No one knows who controls what and who decides what. The focus of the plot of the series "Billions" is the confrontation between two prominent personalities.
We are with you in New York, where we are witnessing the clash of Chuck Rhodes, the local prosecutor with an iron character, and Bobby Axeldorf, a real genius who hopes for success in the planned financial scam. Bobby makes dubious investments that attract Chuck's attention. He tries to get to see Axeldorf, but the latter is not so simple.
The personification of the confrontation of politics and business in the third season of the project "Billions". This is the new "house of cards" on modern television. Fans of the genre strongly recommend! Enjoy watching.
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Human Nature:
 «Human Nature» — сингл Мадонны из альбома Bedtime Stories, выпущенный в 1994 году.
 «Human Nature» — сингл Майкла Джексона из альбома Thriller, выпущенный в 1983 году.
 Human. :II: Nature. — студийный альбом группы Nightwish, вышедший в 2020 году.

redpajama_set_name: RedPajamaWikipedia


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Report: Iran Passes Death Sentence on 'Israeli Spy'
Tehran's chief prosecutor says the suspect's identity is to be announced after approval of the verdict by Iran's Supreme Court.
Iran has imposed a death sentence on a man suspected of spying for Israel, local media reported on Sunday.
Mahmoud Ahmedinejad at a press conference in New York on Sept. 24, 2010.Credit: AP
Iran: UN Agency Sending Nuclear Spies, Not Inspectors
Iran Nuclear Scientist Killed by Car Bomb in Tehran
Egypt Charges New Suspect Over Espionage for Israel
The semiofficial Mehr news agency quoted Abbas Jafari Dowlatabadi, Tehran's chief prosecutor, as saying, The spy has been sentenced to death ... (His) identity will be announced after approval of the verdict by Iran's Supreme Court. He did not say when that would be.
Dowlatabadi said three more cases of espionage were under review by the Iranian judiciary. He did not elaborate.
Israel had no immediate comment.
Iran and Israel have been enemies since the 1979 Islamic revolution in Iran, and Tehran periodically announces arrest of people suspected of spying for Israel.
In 2008, Iran executed Ali Ashtari, an electronics salesman convicted of relaying information on the country's nuclear program and other sensitive data to Israel's Mossad intelligence agency.
A court in 2000 convicted 10 Iranian Jews of spying for Israel in a closed-door trial and sentenced them to prison terms ranging from four to 13 years. All were released before serving out their full sentences after international pressure.
The report on the latest death sentence came as Israel continued to press for curtailment of Iran's nuclear program.
Israel, the United States and many Western countries contend that Iran's nuclear program is intended to produce nuclear weapons. Iran denies that, saying its program is for peaceful purposes, such as generating power.
Israel considers Iran a strategic threat because of its nuclear program and missiles. Israel has said it prefers to resolve the issue through diplomatic means but has not taken a military operation off the table.

redpajama_set_name: RedPajamaCommonCrawl


Class of 2019 quarterback Ryan Hilinski is set to visit South Carolina this Saturday when the Gamecocks face the Tennessee Volunteers in the first night game of the season.
Lately there have been questions about Jake Bentley's role at quarterback, and Hilinski's visit has started some chatter. This will be Hilinksi's first time on the sidelines of a regular season game since committing to South Carolina in April.
After the Gamecocks' recent struggles, some speculated Hilinski might flip his decision to a team with a stronger season. When Hilinski announced his visit on Twitter saying "Home is where the heart is. I'm a gamecock through and through!" Gamecock fans were reassured his commitment would stay with South Carolina.
Hilinski comes with an impressive record. He is one of the top five quarterbacks in the nation for his class and was chosen to participate in the Pro Football Hall of Fame World All-Star Bowl on Dec. 22 in Mexico City. Only the top 70 high school players in the world were selected.
South Carolina was the first school to offer Hilinski a place on its team. Hilinski said he knew that Muschamp would be a vital coach for his collegiate career and would create a family atmosphere.
"It just seems to me that he's a great guy and he's a family guy and that's a big deal to me and my family," Hilinski said.
Hilinski's personal background played a large role in his decision as well. After Hilinski lost his brother Tyler Hilinski, the former Washington State quarterback, Hilinski was determined to continue his football journey.
Hilinski hopes to wear number three after committing to South Carolina to keep his promise to honor his brother.
Kickoff for the game against Tennessee is at 7:30 p.m., and Gamecock Nation will see Hilinski under the lights of the sideline at Williams-Brice on Saturday.


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THEOS (ang. THai Earth Observation System) – tajlandzki satelita przeznaczony do obserwacji powierzchni Ziemi: kartografii, monitorowania rolnictwa, zarządzania lasami, monitorowania wybrzeży i oceny ryzyka powodzi. Właścicielem satelity jest tajlandzka agencja GISTDA, a misję finansuje ministerstwo nauki i technologii (koszt ok. 160 mln USD). Misja ma trwać przynajmniej 5 lat.

Do stycznia 2009 roku satelita wykonał ponad 6100 zdjęć.

Pierwotnie przewidziany do wyniesienia w listopadzie 2007 rakietą Rokot-KM, po wielokrotnych przekładaniach startu, wystrzelony został dopiero 1 października 2008 za pomocą rakiety Dniepr. Statek okrąża Ziemię po orbicie heliosynchronicznej, z punktem zstępującym o godzinie 10:00.

Budowa i działanie
Satelita został zbudowany przez firmę EADS Astrium na podstawie kontraktu z 19 lipca 2004 roku. Firma odpowiadała także za budowę zaplecza naziemnego potrzebnego do obsługi satelity i przetwarzania danych przez niego nadsyłanych, oraz za wyszkolenie 20 osób personelu. Centrum kontroli misji mieści się w Sri Racha, w prowincji Chonburi. Centrum przetwarzania danych mieści się w Bangkoku.

Za odpowiednie położenie statku na orbicie odpowiada system stabilizacji trójosiowej, szukacze gwiazd, żyroskopy, odbiornik GPS, szukacze Słońca i magnetyczne mechanizmy zamachowe. Statek posiada silniczki korekcyjne z zapasem 82 kg hydrazyny. Baterie słoneczne (GaAs) dostarczają do 840 W energii elektrycznej.

Statek może szybko zmieniać swoją orientację w przestrzeni, w zakresie ±45º obrotu i nachylenia (45º nachylenia w 60 sekund; 30º obrotu w 60 sekund). Dokładność wyznaczania położenia wynosi 0,02º, a jego regulowania 0,12º.

Ładunek użyteczny
Rozdzielczość przestrzenna kamery panchromatycznej szacowana jest na ok. 2 m (0,45÷0,90 μm), a wielospektralnej na 15 m w (0,45÷0,52 μm, 0,53÷0,60 μm, 0,62÷0,69 μm, 0,77÷0,90 μm). Zdjęcia są gromadzone w pamięci pokładowej (51 GB) oraz wysyłane na Ziemię łączem w paśmie X o prędkości 120 Mbps. Komputer pokładowy zapewnia wstępną kompresję zdjęć na poziomie 2,8-3,75. Wysyłanie rozkazów odbywa się w paśmie S.

Uwagi

Przypisy

Bibliografia

Satelity obserwacji Ziemi
Tajlandzkie sztuczne satelity
Loty kosmiczne w 2008


Allen bradley slc 500 processor unit 1747-l532 ser. Allen bradley slc 500 processor unit 1747-l532 ser.
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The cellist Sol Gabetta was born in Cordoba, Argentina, in 1981 as the daughter of French and Russian parents. She was only ten when she won her first competition in Argentina, and has received many more awards since then: she won the Moscow Tchaikovsky Competition and the ARD Competition in Munich, and has been awarded the Natalia Gutman Prize. In 2004 she created an international sensation when, as winner of the Crédit Suisse Young Artist Award, she gave her début with the Vienna Philharmonic under Valery Gergiev at the Lucerne Festival.
From 1992–94 Sol Gabetta studied with a scholarship at the Escuela Superior de Musica Reina Sofia in Madrid, after which she moved to Switzerland to pursue further studies with Ivan Monighetti at the Basel Academy of Music. After further years of study with David Geringas, she took her concert exam in 2006 at the Hanns Eisler Musikhochschule in Berlin.
In the last few years, Sol Gabetta has made guest appearances with the Munich Philharmonic, the Vienna Symphony Orchestra, SWR Stuttgart, the National Symphony Orchestra of Washington, the Calgary and Seoul Philharmonics, the City of Birmingham Symphony Orchestra, the Philadelphia Orchestra, the Detroit Symphony Orchestra, the Royal Philharmonic Orchestra and Het Residentie Orkest, the Trondheim Soloists and the orchestras of Euskadi, Teneriffa and Sevilla. She regularly gives concerts together with the Basel Chamber Orchestra.
Ms. Gabetta regularly appears at major festivals such as the Rheingau Music Festival, in Verbier, at the Menuhin Festival in Gstaad, the Schwetzingen Festival, the Bonn Beethoven Festival, the Schleswig-Holstein Music Festival, the Schwarzenberg Schubertiade and the Saratoga Festival. She has also founded her own chamber music festival in Switzerland with the name "Solsberg", where she performs together with her chamber music partners, who include Henri Sigfridsson, Mihaela Ursuleasa, Baiba and Lauma Skride and Patricia Kopatchinkskaya.
Sol Gabetta records exclusively on the RCA label (Sony Music). Her début CD featuring works by Tchaikovsky, Saint-Saëns and Ginastera, recorded with the Munich Radio Symphony Orchestra under Ari Rasilainen, shot straight to the top of the German classical charts, and brought the coveted Echo Klassik Prize for 2007 as instrumentalist of the year. Her second CD. with Vivaldi concertos recorded together with the Italian ensemble Sonatori de la Gioiosa Marca, was released in September 2007, and stayed in Germany's classical charts for over six months. 2008 saw the release of not one, but two CD's by Sol Gabetta. One featured a Shostakovich programme: the Cello concerto no.2 with the Munich Philharmonic Orchestra under Marc Albrecht, and the Sonata for cello & piano (with the pianist Mihaela Ursuleasa). The second CD is entitled "Cantabile" and contains opera arias and songs by Offenbach, Bizet, Tchaikovsky and others; on this album, Ms. Gabetta is accompanied by the Prague Philharmonic conducted by Charles Olivieri-Munroe. After it was released, the Shostakovich CD was awarded the coveted French music award Diapason d'Or by the clafssical music magazine Diapason and received the German Echo Klassik award 2009 as concerto recording of the year. In 2011 she received her third Echo Klassik award for her recording of the Elgar cello concerto.
A generous private grant from Hans K. Rahn enables Sol Gabetta to play one of the rare and valuable cellos built by G. B. Guadagnini; the instrument dates from 1759. She has held a teaching post at the Basel Academy of Music since October 2005.


Regan came to feel that this astrologer held disproportionate power over global politics, far more than many cabinet members vetted by Congress. "The president's schedule is the single most potent tool in the White House," Regan writes. Nancy Reagan spoke to this woman nearly every weekend and grew furious when the White House staff made last-minute adjustments to the schedule without leaving time for her astrologer's approval.
The astrologer's name was Joan Quigley. She was raised in a genteel San Francisco family, the closest California comes to old money. Her father owned a hotel and sent Joan and her sister, Ruth, to one of San Francisco's toniest private schools. When Joan was fifteen, she sat in on one of her mother's astrological consultations and was amazed by the certainty with which the astrologer could see the future and by the clean, almost mathematical quality of her methods. There was no communing with far-off spirits, no chanting, no tinctures, no grotesque velvet table covers.
By the time Quigley began working with the Reagans, she was in her fifties and had been working as an astrologer for decades, with high-profile clients such as the talk-show host Merv Griffin. She dressed like a card-carrying member of the Daughters of the American Revolution, her eyebrows always thinly plucked and her blonde hair secured in a bob.
Although Quigley had worked closely with the Reagans during the election, Nancy had stopped returning her calls during their first few months in the White House. But after the president was nearly killed by a shooter as he was exiting the Washington Hilton, Nancy reached out to Quigley again. "Could you have told about the assassination attempt?" she asked. Yes, Quigley assured her, she could have. She resumed her position in Nancy's inner circle. She knew her involvement would need to be kept secret, as it was during the campaign. "I would be giving up my time and effort like all those who take part in any administration, sacrificing the rewards they commanded in the private sector in order to serve their country. I was aware, however, that unlike them I would not have the prestige they had while serving." But Quigley worried about Reagan's safety; his chart suggested that he was entering a risky period, and Quigley felt it was her duty as an American to protect her president from harm.
Millions of Americans read their horoscopes each month. Newspapers frame these monthly horoscopes as entertainment, and their devoted readers assure their skeptical friends that they skim them with breakfast "for fun," too ashamed to admit to their instinct for magical thinking. People consult horoscopes for the same reason they consult advice columns—because everyone craves reassurance and because they address our ambitions and fantasies, the subjects that quietly consume us but that our daily lives often require us to ignore.
But unlike advice givers, there's never been an astrologer who's ascended to household name. The practice has too witchy an association. If Nancy Reagan had been open about her relationship with Quigley, if she had admitted that Quigley's forecasts afforded her a greater sense of safety than any Secret Service report, the practice might have lost its taint, and perhaps Quigley would have become America's first celebrity astrologer, remembered less for the accuracy of her predictions than for the way she made people feel.
Quigley waited and waited for a formal invitation to the White House. She was not invited to the party celebrating Reagan's election in 1980 or his reelection in 1984—even though she considered herself crucial to both victories. Although she and Nancy spoke on the phone constantly, they'd met only once in person, and quickly, at an election event in San Francisco in 1976.
In April 1985, Quigley booked a trip to D.C. She didn't tell any friends or family she'd be in town. Her trip had only one purpose: to take up Nancy on her open-ended invitation to tea at the White House. She happened to be in town on the night of a state dinner honoring the president of Algeria, and Nancy encouraged her to attend.
Quigley was careful not to wear any of the cocktail dresses she'd worn on The Merv Griffin Show. She went with an inconspicuous pale-blue gown. She was desperate to wear a new red dress, but she knew that red was Nancy's color and didn't want to upset her. Quigley hobnobbed with the editor of Newsweek, the actress Cheryl Ladd, and various journalists and political types. Quigley introduced herself as a writer from California and evaded further questions. She stepped out of the way anytime she saw the flash of a camera—for Nancy's sake, she wanted no photographic evidence of her presence. "Nancy quite obviously did not want to make a point of my being there," she later writes. She was seated at the same table as Vice President George H. W. Bush, whom she complimented for his debating skills. She ate seafood mousse and drank champagne.
Quigley expected a thank-you. Nancy had promised as much—that one day, after they were out of office, Nancy would tell the world just how much Quigley had done for the Reagans and the country. Shortly after Don Regan published his memoir, in which he complained at length about the unchecked powers of an unnamed astrologer, someone within the administration leaked Quigley's name to the press. Nancy was frantic to discredit the story. It was Ruth, Joan's sister and roommate, who picked up Nancy's call.
"This must never come out!" Nancy said.
"Not while you're in office," Ruth replied. "But what about after you are out of office?" She, too, hoped that her sister would receive her proper due.
Quigley, who died in 2014, said she foresaw Nancy's betrayal. "Struggle has been in my charts," she once told a reporter. She knew she could "expect no gratitude" from the Reagans, and yet she said she did not foresee writing a memoir defending her place in history. Knowing in advance that the Reagans would hurt her made no difference. It hurt all the same.
Jessica Weisberg is an award-winning writer and producer. Her writing has appeared in The New Yorker, the New York Times, Harper's, and The Atavist, among other publications, and been nominated for a National Magazine Award. She was a producer on the podcast Serial and runs the features unit at Vice News Tonight on HBO, for which she's been nominated for an Emmy. She lives in Brooklyn.
Excerpted from Asking for a Friend: Three Centuries of Advice on Life, Love, Money, and Other Burning Questions from a Nation Obsessed, by Jessica Weisberg. Copyright © 2018. Available from Nation Books, an imprint of Perseus Books, LLC, a subsidiary of Hachette Book Group, Inc.


If this is an emergency, please call your vet!
We have a variety of protocols that we follow. The one that we choose will depend upon the severity of the symptoms.
Regardless of the severity of symptoms or which type of vet treated the dog, the NUMBER ONE most important aftercare instruction that can 100% affect your dog's recovery is CRATE REST. We can't emphasize enough the importance of CRATE REST for the alotted number of weeks that the vet recommends. A dog may seem 'better' after a few days or a couple of weeks, but one flight of steps...one jump off the couch...one happy dance... any one of those actions can undo all of your hard work and you'll all be back to square one.
Dodgers List has this on their homepage - "Make sure you have protected your dog's spinal cord with 100% STRICT crate rest 24/7 only out at potty times. Carry to and from the potty place. At potty times just the very fewest of footsteps to get the job done then carry back to the recovery suite."


2018 is the summer when I stopped having one hand to do things with, plus a left hand. Or the summer when – through an injury that reminded me of my fragility – I was able to become stronger, better balanced, and more coordinated.
Step 1: Attach metal bracket to wooden frame using provided screws.
Step 2: Fasten screws and bracket.
Step 3: Attach lower support to table legs using "C" brackets.
Step 6: Fasten all screws from Step 5 using included Allen Key.
Step 5? Where's Step 5?? What happened to Step 4?!
You find yourself building a piece of furniture and halfway through you realize that your instruction booklet is missing a page. You're left hanging; there's no obvious next step and you're at a loss of what to do. Your cursing starts picking up speed and hopefully – for the sake of your new furniture and for the people walking on the sidewalk below – your half-assembled table is too heavy for you to pick up and throw out the window.
The scene probably hits close to home because we all know how infuriating this is. In a strange way there's a lot of similarity with digital audio that has been edited without looking for a zero crossing.
We see in two dimensions. It sounds strange, but have a look around you. What you see with your two eyes is that some things are smaller and some are larger, but the only data that comes to us through our eyes is height and width. Depth is a magical addition we give the world through years of experience in knowing whether a small thing is far away, or just small. If you throw a baseball to a friend standing 10 metres away, the only information each eye gives you is that the ball is shrinking until it arrives at your friend, who's smaller than she'd be if she were closer to you, and larger than she'd be if she were farther away.
That's the one-eyed picture of the world. But once we add a second eye which gets a slightly different image because of its gap with the first, depth just seems to appear. The most miraculous thing about the optical illusion that we call our perception of the world is that we think nothing of it. Yet the ability to assemble two slightly different images of the world and – fairly accurately – interpret a third dimension gives a person a huge advantage over cyclopses and pirates who can't be sure whether pterodactyls are swooping down at them, or just growing really quickly.
The French writer Antoine de Saint-Exupéry, famous for bringing the Little Prince into the world, famously said "perfection is achieved, not when there is nothing more to add, but when there is nothing left to take away." Maybe that's why the Little Prince was from such a small planet.
This is the sort of quote you can imagine neatly screened on the wall of a super hip firm in San Francisco who designs artisanal pencils and garbage bins, working off empty desks in a restored carpet factory. Yet for the mass of our culture represented by Walmart, big box stores, McNuggets, and weekend sale madness flyers – Saint-Exupéry's quote might as well be flying around on a little planet in outer space.
Tiller rope. Oarlock. Skeg. Gunwale. These are all parts of rowing boats that you will not see when you walk into your local gym and inspect their fleet of indoor rowers. What's interesting when you look at these machines is if they didn't bear the name that connects it with the thing people do in boats, it might be a real leap to figure out how they were even associated. Yet the rowing machine has become so established in its own right that there are even competitions held. Love the idea of sliding back and forth while pulling a handle on a chain, but hate the water? Maybe this is for you.
The indoor rower is good example of a design that has shed most of the vestiges that connect it to its waterborne counterpart. For avid rowing enthusiasts, a person could easily imagine a rowing machine complete with a useless hull and even a water sprayer to make the 'rower' feel a bit closer to the lake. Absurd as they may be, these elements sometimes go a long way in making users feel more acquainted with a new machine. They're called skeuomorphs, and are elements that have no functional purpose, but resemble familiar elements that may have been necessary in designs once upon a time.
Every name has a story; some names have strange ones and others are more boring than you think. The rock group Lynyrd Skynyrd took its name from a high school gym teacher who made a point of enforcing the school's policy against men wearing their hair long. The rock group changed the vowels and added a D to the end of Leonard Skinner's name to avoid a lawsuit, and made him the most famous gym teacher in history (and got a ton of mileage out of the letter Y acting as a vowel).
There are other names with less colourful histories which take words and compress them down so they roll off the tongue a little more smoothly – Nabisco, from National Biscuit Company, or Adidas, from the founder's name: Adolf "Adi" Dassler.
The humble XLR cable, used so commonly in the audio world, is a bit of a surprising acronym, maybe because anything that starts with an X sounds like it should be drinking Red Bull and doing backflips off high cliffs.
Furthering my strong conviction that the best use of a video camera is either speeding time up, slowing time down, or sending it in reverse.
The year is 1887 and in what is modern-day Poland, a physician-linguist named L. L. Zamenhof set out to solve a problem. In his town a handful of different languages were being spoken, and these language lines divided their speakers into tribes that hardly intersected.
Zamenhof's solution? Construct a universal language that everyone would speak and which would bridge the gap between people that were physically neighbours, yet psychically foreigners. The language was Esperanto, and suffice to say, you don't see it on the backs of cereal boxes tucked underneath the English and French.
Esperanto may have never caught on as the universal language of a nineteenth-century idealist's dreams, but the idea of a common form of communication isn't completely foreign, if you're willing to include the way computers communicate with the gadgets that are attached to them.
Can you taste the difference between a lemon and a strawberry? I hope so. If you, blindfolded, had a chunk of each fruit fed to you, how would you describe the difference? Certain attributes like texture and bitterness might be obvious but there are elements of the taste that'd be harder to describe. Yet your difficulty in finding the words wouldn't mean you'd have any trouble distinguishing a lemon from a strawberry.
When it comes to sound we have a real challenge when we talk about timbre. Timbre isn't a Canadianized spelling of the word you yell when a tree is falling down or if you're Pitbull (feat. Ke$ha) wanting to make a night you won't remember or be the one you won't forget. The timbre we're talking about is pronounced TAM-burr and we know it comes from French but there isn't a really clear translation for it.
If you've ever played the board game Mouse Trap, you can easily understand one of the most interesting digital audio techniques: sidechaining. You might remember that Mouse Trap involves a scheme for capturing mice that's far more complex than your standard cheese/spring/snap design available at the dollar store; Mouse Trap was a child's introduction to the incredible world of Rube Goldberg machines.
The fact that there was even a board game connected to this incredible scheme was a surprise to me as I went back to do a bit of research, because all I remember was turning a crank which makes a red hexagon hit a boot that kicks a bucket that sends a marble down a ramp...until finally a small cage descends on whatever poor mouse happens to be waiting below it. I don't ever remember rolling a die or moving my pieces around the board – I'm pretty sure we'd just set up the machine and run it again and again until we got bored.
Every space has a sound, like every person has a fingerprint.
We've talked a lot about the way that sound happens physically, and by now you probably can recite in your sleep the way that anything vibrating causes all sorts of disturbances amongst the air molecules surrounding it, and those air molecules then bump into their neighbours, and those into theirs, until the collisions eventually reach your ear.
At its most basic level this is where the conversation ends, because we haven't discussed what happens to the 99.999% of those air molecules that don't move in a direct line from the sound source to your ear drum. What happens is reverb.
Gold is one of the most durable value keepers in the world. Yet long ago, sneaky folks realized that gold could be mixed with less valuable metals to dilute its purity and create something that may have appeared similar, but wasn't the same. In some movie you've probably seen a pirate or some market vendor bite a gold coin to figure out its purity –that's because pure gold is relatively soft, and a bite could [roughly] indicate its purity.
Nowadays we use the carat measurement to determine gold' purity instead of our teeth, and although it might give them a bit less business, our dentists are probably thankful for it. 24 carats is the goldest gold you can get and if there's any other metal present it's of such a negligible quantity that it's not even worth mentioning.
In the world of digital audio – specifically when it comes to frequencies and EQing – we have something similar that we call Q. What is Q? The Quality factor. Yet aside from having a technical role in mixing the [very] occasional gold-certified record, what can an EQ possibly have to do with gold?
2300 years ago, a Greek mathematician named Euclid wrote what would become one of the most successful and influential books of all time. It didn't contain characters, a plot, or even morals, but was filled with mathematical descriptions of the way our world is composed. Although his phrasing was far more technical and arcane, many are familiar with the postulate of his Geometry which states that two parallel lines will never intersect. Hurtling down the highway or aboard high speed trains, we at least hope he was right.
Well, well, well, Euclid. As you were figuring out other earth-shattering truths such as the roundness of circles and the pointiness of triangles, who would have thought that your famous unintersecting lines would years later also lend their name to one of the most successful and influential studio techniques?
One of the wildest experiences I ever had was eating in the dark. And when I say dark, I mean dark. The restaurant is called O.Noir, and I guess you could call it a concept restaurant; not only do they feed you, but they give you the experience of a blind person – after ordering your food in a dimly lit bar area, you're guided into a completely lightless room and seated at your table by one of the restaurant's blind waiters. After struggling for minutes to see anything, you eventually give up. You're in darkness so deep that having your eyes open or closed makes absolutely no difference.
And then the food arrives. I should also add that for the more adventurous souls, the restaurant offers "surprise" dishes – that is, well, exactly what it sounds like. I distinctly remember the first bite of something with a slippery texture like a cooked mushroom, the smell of tomatoes and garlic. As I realized, it was pasta.
Every day we deal with the problem of squeezing more of our world into smaller containers. How many books can you fit on your shelf? How many hours of sleep can you fit into your busy schedule? How many clothes can you cram into your suitcase as you pack for a trip? As time goes by, we gradually become crazier with this, always trying to squeeze a little more into a little less: we squeeze the books a bit closer, fold the shirts a bit tighter ... you get the idea.
When it comes to audio, we do exactly the same thing, though you wouldn't know it. If the world of physical sound (that is, vibrations in the air) is one shore and the world of digital audio (that is, the way we represent those vibrations numerically) is the other, we need some sort of boat or bridge to shuttle between them, otherwise we're in for a mean soaking.


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Is 'Fallout: 4' too Good?: Bethesda Sued by Player for Making the Game too Addictive
Dec 23, 2015 06:00 AM EST
A man from Russia has filed a lawsuit against the creator of "Fallout: 4" for making the game too addictive that he lost his job and wife after playing for two weeks straight.
'Fallout 4,' 'Star Wars: Battlefront' & More Games: Top 5 Games of 2015
Nov 26, 2015 06:00 AM EST
We compiled five of the best games released this year.
'Fallout 4' Guide: How to Earn More Trophies
Nov 25, 2015 05:24 PM EST
"Fallout 4" gamers will surely want to step up their game in this recently released game from Bethesda Game Studios.
Best PC Games in 2015: Top 5 Must-Play Titles
We compiled five of the best PC games for this year.


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Diabetes Research: Improving Lives on the Path to a Cure 2015
Redefining Reality: How the Special Diabetes Program is Changing the Lives of Americans with Type 1 Diabetes
Fiscal Year 2019 Budget Request
Progress Toward a Cure for Type I Diabetes: Research and the Artificial Pancreas 2017
Diabetes Research: Reducing the Burden of Diabetes at All Ages and Stages 2013
Testimony Before the Senate Special Committee on Aging on Wednesday, July 15, 2015
Griffin P. Rodgers, M.D., M.A.C.P.
Director, NIDDK, NIH, DHHS
Chairman Collins, Senator McCaskill, and Members of the Committee, as Director of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), I thank you for your invitation to testify at this hearing on type 1 diabetes. On behalf of the NIDDK and the other Institutes and Centers of the National Institutes of Health (NIH) within the U.S. Department of Health and Human Services (HHS), I am pleased to report on significant recent scientific advances and future research opportunities in type 1 diabetes and its complications.
Long recognizing the importance of diabetes research toward improving the health of people affected by the disease, the NIH has invested over $1 billion a year in diabetes research in each of the last several years. This investment has been complemented by the support and efforts of our research partners - academic institutions, the U.S. Food and Drug Administration (FDA), the Centers for Disease Control and Prevention (CDC), and charitable and patient advocacy groups such as JDRF (formerly the Juvenile Diabetes Research Foundation), the Leona M. and Harry B. Helmsley Charitable Trust, and the American Diabetes Association (ADA). These partners share our goals of preventing, treating, and ultimately curing type 1 diabetes. Through the invaluable support of the Congress and the Administration, through collaborative and coordinated research efforts, through the hard work of our researchers, and through the dedication and generosity of our clinical trial volunteers, we have made important strides toward these goals. I am pleased to be here today to describe recent scientific advances and future opportunities in type 1 diabetes research, including research supported by the recently renewed Special Statutory Funding Program for Type 1 Diabetes Research (Special Diabetes Program). With the Special Program now funded through Fiscal Year 2017, we look forward to taking advantage of the opportunities I'll describe to you today.
Type 1 diabetes primarily strikes children and adolescents, but it can begin at any age. It is a lifelong disease that affects Americans of all ages, including seniors. Type 1 diabetes is an autoimmune disease, in which the body's immune system launches a misguided attack and destroys the insulin-producing beta cells found in clusters called islets within the pancreas. Insulin is a hormone that helps the body regulate glucose levels in the blood. Because their body no longer produces insulin, people with type 1 diabetes - or the parents of young children with the disease - must do the work of the lost beta cells. Thus, the children here today and people of all ages with the disease must closely monitor food intake and physical activity levels, monitor blood glucose levels many times each day and night, and administer insulin through injections or an insulin pump. This is an enormous and constant burden on them and their families, and greatly affects quality of life. Despite their vigilance, they remain susceptible to dangerous and frightening episodes of hypoglycemia (low blood glucose) and to developing long-term complications affecting their eyes, kidneys, nerves, heart, and other organs. Thus, it is imperative to pursue research to identify prevention strategies and improved treatments, while striving for a cure.
Improving the Outlook for People with Type 1 Diabetes
Research has had a dramatic and beneficial impact on the health and quality of life of people with type 1 diabetes. A major contributor to this success is information that has been garnered by the NIDDK's landmark Diabetes Control and Complications Trial (DCCT) and its follow-up study, the Epidemiology of Diabetes Interventions and Complications (EDIC). DCCT, which began in 1983, compared the effect of intensive blood glucose control versus what was conventional care at that time on the long-term health of people with type 1 diabetes. DCCT demonstrated that intensive blood glucose control, beginning as soon as possible after diagnosis, prevented or delayed the development of complications of the eyes, kidneys, and nerves. After DCCT ended, the EDIC study - which began in 1994 and is still ongoing - followed the original DCCT participants and demonstrated enduring protective effects of intensive glucose control on eye, kidney, nerve, and heart complications. These results have transformed clinical care for people with type 1 diabetes, with doctors now recommending that people with the disease practice intensive control as early in the course of the disease as safely possible.
However, despite unequivocal evidence of the benefit of intensive glucose control, many people - especially teens - are not able to achieve the intensive control that researchers helped DCCT participants achieve. Even DCCT participants themselves could not maintain this control after the trial ended and they were not receiving diabetes treatment from the research staff. Data from children participating in the SEARCH for Diabetes in Youth study (SEARCH), which is funded by the NIDDK and CDC's Division of Diabetes Translation, show that one out of five teenagers with type 1 diabetes have hemoglobin A1c (HbA1c) levels - a measurement of blood glucose levels over time - above 9.5 percent, which is higher than the recommended level of less than 7.5 percent. Teenagers' mean HbA1c level is also closer to that achieved by the conventional than the intensive control group in DCCT, indicating that achieving the recommended intensive glucose control and attaining its long-term protective effects is particularly challenging in this age group. Thus, new approaches to improve glucose control are urgently needed.
Even though it has been over 30 years since DCCT began, critical insights continue to emerge. Recent results from DCCT/EDIC show that people with type 1 diabetes who intensively control their blood glucose levels early in the disease are likely to live longer than those who do not. Higher average blood glucose levels and increased protein in the urine - a marker of diabetic kidney disease - were the major risk factors for death.1 These results emphasize the importance of early and intensive blood glucose control. They also demonstrate the fruits of a long-term research investment - the NIDDK has supported DCCT/EDIC for over 30 years, and translation of these insights into long term outcomes would not have been available without sustained support. Additionally, many current studies supported by the NIDDK, such as development of artificial pancreas technologies and clinical trials of agents to preserve beta cell function, stem from DCCT/EDIC research showing that controlling blood glucose levels is key to maintaining long-term health. Thus, results from DCCT/EDIC have been transformative and far-reaching.
Because type 1 diabetes is a complex disease involving many different organ systems, propelling research progress involves partnerships among scientists with diverse backgrounds and expertise. NIH has also valued its partnerships with academic institutions, with other HHS agencies, and with patient advocacy groups such as JDRF and ADA. These partnerships have allowed us to work together toward common goals and reduce duplication. Our most important research partners are people with or at risk for type 1 diabetes who participate in clinical research studies. We are inspired by their commitment, not only for themselves and their families, but for future generations who may benefit from findings stemming from these research studies.
Toward the goals of preventing, treating, and curing type 1 diabetes and its complications, the NIH vigorously supports research focusing on all stages of the disease: to prevent the autoimmune attack before it starts; to stop the autoimmune attack early in the course of disease to protect remaining beta cells; to improve blood glucose control in people with established disease; to restore beta cell function in people with significant beta cell loss; and to prevent, treat, and reverse complications. I am pleased to share with you some of the exciting recent advances in type 1 diabetes research, many of which were reported in just the last year.
Understanding the Causes of Type 1 Diabetes Toward Disease Prevention
To achieve our goal of preventing type 1 diabetes, it is imperative to understand the underlying causes of the disease. A person's risk for developing type 1 diabetes involves both genetic and environmental factors, and many genes contribute to disease risk. Thus, research on genetic and environmental contributors is critical toward developing prevention strategies.
In recent years, we have made significant progress in understanding genetic contributors to type 1 diabetes. About a decade ago, only a few culprit genes had been identified. Now, because of the NIDDK's Type 1 Diabetes Genetics Consortium and other groups, we know over 50 genes or genetic regions that contribute to disease risk. This represents about 80 percent of the genetic contributions to disease, making type 1 diabetes one of the few polygenic diseases (in which many genes are involved) for which most of the genetic susceptibility has been identified.
The NIDDK is building on this progress by supporting research to pinpoint the genes within these regions that could be influencing disease. We also support research to understand the function of identified genes to determine how they may be involved in disease, which could point to new targets for prevention or treatment. For example, NIDDK-supported researchers studied one of these genes, called Clec16a, whose function was previously unknown. They found that it encodes a protein involved in quality control of mitochondria, the cell's "power plants." Over time, mitochondria may develop problems, requiring recycling and replacement. Using mice, researchers found that reducing the amount of Clec16a protein caused too-frequent mitochondrial recycling. Moreover, beta cells that lack Clec16a are less able to process energy and produce less insulin in response to rising blood glucose than normal beta cells do. Notably, people with a common mutation of CLEC16a that is linked to type 1 diabetes also have lower levels of Clec16a protein and poorer insulin response than people with other variants of the gene, suggesting the protein's role in humans is similar to its role in mice. Further research could determine whether modulating the mitochondrial recycling program helps prevent the disease.2
However, genetics does not represent the full picture. The CDC and NIDDK co-led SEARCH for Diabetes in Youth study reported the first national surveillance data on childhood diabetes and found that the prevalence of type 1 diabetes in people under age 20 rose by 21 percent between 2001 and 2009, and that the disease is also an increasing burden in minority youth.3 Rising rates of type 1 diabetes suggest that there is an unknown factor - or factors - in the environment that interacts with genetic risk to trigger disease onset or protect against it. Identifying these factors - such as infectious agents, dietary factors, or some other agent - is critical to understanding the disease process and to developing prevention strategies. Toward these goals, the NIDDK supports an ambitious, long-term clinical research study called The Environmental Determinants of Diabetes in the Young, or TEDDY. After screening over 425,000 newborns, TEDDY is currently following over 6,000 of them at high genetic risk of type 1 diabetes until they are 15 years old. During that time, researchers and devoted parents regularly collect information about the children's diet, allergies, illnesses, and other environmental exposures. Over 2.7 million biological samples have been collected to date. These samples are a treasure trove of information that is now being analyzed with state-of-the-art genomic, metabolomic, and proteomic technologies to uncover possible environmental triggers and protective factors. The TEDDY study represents an unparalleled resource that can give unique insight into type 1 diabetes and children's health.
TEDDY is also giving us knowledge about other autoimmune diseases, such as celiac disease (gluten intolerance), which shares some genetic risk factors with type 1 diabetes and often occurs in the same individuals. TEDDY recently found that more than one quarter of children with two copies of a high-risk variant in a specific group of genes develop an early sign of celiac disease by age 5 - results that could have future implications for celiac disease screening in young children.4
Testing Strategies To Stop the Autoimmune Attack and Preserve Beta Cells
After a person is diagnosed with type 1 diabetes, it is critical to preserve remaining beta cells to maintain some insulin production and achieve good blood glucose control, which research has shown could improve long-term health. NIDDK's Type 1 Diabetes TrialNet and the National Institute of Allergy and Infectious Diseases' (NIAID's) Immune Tolerance Network have both tested agents in people with newly diagnosed type 1 diabetes to determine if they could halt or slow the autoimmune attack and protect remaining beta cells. Some agents have shown promise, including the drug abatacept and the anti-CD3 monoclonal antibody teplizumab. TrialNet is building on these results in newly diagnosed patients and now supports clinical trials testing whether these agents could prevent type 1 diabetes in relatives of people with the disease. The ability to conduct such prevention trials is based on research showing that blood tests can accurately identify relatives of people with type 1 diabetes who are at high or moderate risk of developing the disease within five years.
Looking forward, TrialNet is uniquely positioned to test new and emerging prevention approaches that may stem from studies such as TEDDY. Additionally, the ability to screen people for risk of type 1 diabetes with a blood test allows us to identify those who could benefit from a prevention strategy if one emerges; the NIDDK also supports research by small businesses to improve predictive tests to be used in clinical trials, as well as for use in a public health setting once prevention approaches are identified. Thus, the Special Diabetes Program has enabled the creation of a unique research pipeline with goals of discovering strategies to protect beta cells, testing those strategies in people, and identifying those who could benefit from effective strategies on a larger public health scale.
Developing Technologies To Improve Glucose Control
The results of the DCCT/EDIC studies that I described earlier show the importance of early and intensive blood glucose control to patients' long-term health. However, type 1 diabetes is an extremely burdensome disease to manage for even the most vigilant of patients, and intensive therapy brings with it the potential for acute episodes of hypoglycemia. Nocturnal hypoglycemia, an imbalance of glucose supply and relative oversupply of insulin during the night, can be a worrisome side effect in children on intensive insulin therapy. Thus, it is difficult for people to achieve recommended levels of blood glucose control using current management approaches. Recent research has shown other alarming effects of elevated blood glucose levels: scientists in the Eunice Kennedy Shriver National Institute of Child Health and Human Development-led Diabetes Research in Children Network (DirecNet) found that young children with long-term high blood glucose levels are more likely to have slower brain growth. Researchers did not find significant cognitive differences between healthy children and those with type 1 diabetes, but longer-term studies could shed light on whether differences exist.5 Thus, research findings continue to emphasize the need to develop improved technologies to help people with type 1 diabetes and their families manage their disease and keep blood glucose levels in a healthy range, while reducing the risk of hypoglycemia.
One extremely promising technology to achieve these goals is an "artificial pancreas," which is a device that fully automates blood glucose sensing and insulin administration. Such a device has three components: a glucose-sensing component that measures blood glucose levels and sends information to a computer; an insulin delivery device; and a computer that calculates the amount of insulin needed and thereby "closes the loop" between glucose sensing and insulin delivery. In other words, this technology is designed to do the work of the pancreas with minimal human input.
The NIDDK is working closely with our partners, including the FDA and JDRF, to develop artificial pancreas technology, and I am pleased to report that there has been significant recent progress. Until recently, artificial pancreas clinical trials took place in hospital settings and used laptop computers to run the technology, restricting the activities of participants. Recent trials have built on the success of the inpatient trials, testing ambulatory devices in real-world settings. For example, NIDDK-supported researchers tested a wearable, automated, bihormonal "bionic" pancreas - one that releases both insulin and its counteracting hormone, glucagon - in adults and adolescents with type 1 diabetes. The adults wore this cell-phone controlled device for five days and nights and were unrestricted in their activities - they ate in restaurants, exercised at gyms, and stayed in a hotel, while being accompanied by study staff for their safety. The adolescents wore the same device at diabetes summer camp, also being closely monitored while participating freely in all camp activities. In both trials, compared to usual care of insulin pump therapy, participants had lower mean glucose levels and reduced episodes of hypoglycemia. In fact, the bionic pancreas allowed nearly all participants to achieve recommended levels of blood glucose control.6
In another study, researchers tested unsupervised overnight home use of a closed-loop system in adolescents with type 1 diabetes for 21 nights. During the day, participants used standard glucose sensor and pump therapy and did normal activities. At night, they used the closed-loop system, controlling it on their own, with minimal supervision on only the first night. Results showed that closed-loop control at night improved participants' glucose control during the day and night and reduced the number of episodes of nighttime hypoglycemia.7
Progress is also being made testing the next generation of low-glucose suspend devices - an important component of artificial pancreas technologies. The first-generation device, approved by the FDA in September 2013, suspends the delivery of insulin when glucose levels reach a preset threshold. The next generation device predicts when this level will be reached and preemptively suspends insulin delivery. A recent NIDDK-supported study tested a predictive device over 42 nights in people with type 1 diabetes in their homes. The results showed that, compared to control nights, nighttime hypoglycemia was reduced by over 70 percent when participants used the predictive device.8 Nighttime hours are particularly worrisome for people with type 1 diabetes and their parents. Thus, the reductions in nocturnal hypoglycemia seen in recent studies suggest that new devices have the promise to lead to real and immediate benefits.
To build on these and other advances, the NIDDK plans to support advanced clinical trials on artificial pancreas technology that are expected to generate data able to address safety and efficacy requirements by regulatory agencies regarding the clinical testing of these systems. We also support research being conducted by small businesses to develop innovative technologies that may improve key components of and thus advance progress toward an artificial pancreas, as well as research conducted by academic medical centers studying physiological and behavioral factors. Partnerships between bioengineers designing these devices, clinicians, and behavioral scientists are key to make artificial pancreas use easier, so that as new technologies become available, patients and families can use them. With continued research, artificial pancreas technology can become a reality for people with type 1 diabetes.
Restoring Beta Cell Function
Although the development of artificial pancreas technology represents an important and near-term approach to reduce the burden of managing type 1 diabetes while improving patients' health, it is not a cure. Thus, another major goal of NIH-supported type 1 diabetes research is to identify ways to replace lost beta cells and restore insulin production, which would represent a biological cure for the disease. One way to restore the ability to produce insulin is to replace beta cells through islet transplantation. The current procedure involves purifying islets from a donor pancreas and transplanting them into a person with type 1 diabetes. Research has shown that islet transplantation is highly successful in reversing hypoglycemia unawareness, a devastating complication of type 1 diabetes in which people do not recognize dangerously low blood glucose levels, making everyday tasks, like driving, a danger.
The NIDDK and NIAID co-led Clinical Islet Transplantation Consortium (CITC) has been conducting clinical and mechanistic studies in islet transplantation, with or without accompanying kidney transplantation, to make islet transplantation safer and more effective. The islet alone pivotal, Phase III islet transplantation trial has been completed and the islet after kidney phase III trial has reached its primary endpoint. The Collaborative Islet Transplant Registry (CITR) has shown that both efficacy and safety outcome measures have improved in the 2007-2010 period compared to those from 1999-2006. Both the CITC and CITR's results showed that islet transplantation continues to show improved long-term benefits including insulin independence, improved indications of normal or near-normal blood glucose levels over time, and sustained marked decrease in severe hypoglycemic episodes. I'm pleased to report that the CITC will be submitting a report to the FDA based on these exciting results, toward licensing a pancreatic islet product for transplantation.
One barrier to islet transplantation is the scarcity of donor islets for transplant. A major advance from researchers in the NIDDK's Beta Cell Biology Consortium (BCBC) could help overcome that barrier. The scientists discovered a method to produce, or differentiate, beta cells in the laboratory. Previous attempts resulted in cells that produce insulin, but that do not respond to changing glucose levels. Recently, scientists developed a multistep differentiation process in which they coaxed large numbers of human stem cells into a state that closely resembles beta cells. Importantly, this process can use induced pluripotent stem cells that can be made from adult skin cells obtained from patients with type 1 diabetes. Importantly, these new cells respond to fluctuating glucose levels by increasing or decreasing secretion of insulin, as appropriate. This dramatically improved process for making large amounts of beta cells is a promising step toward developing donor-derived stem cell therapies to replace beta cells lost in type 1 diabetes.9
Another barrier to islet transplantation is the need for transplant recipients to take lifelong immunosuppressive medicines, which often have serious side effects, to prevent their body from rejecting the transplanted islets. One approach to protect the transplanted islets is to encapsulate them in a material that would protect them from an immune attack but still allow them to function. Thus, the ability to make large amounts of beta cells for transplantation which I just described makes developing new approaches to immunomodulation and encapsulation even more urgent.
Another group of BCBC researchers discovered that delta cells in the pancreas, which produce a hormone called somatostatin, could be reprogrammed into beta cells, representing another potential way to restore lost beta cells in type 1 diabetes.10 Building on these and other ground-breaking successes of the BCBC, the NIDDK recently transitioned to a new effort, the Human Islet Research Network (HIRN). HIRN is supporting collaborative, translational beta cell research that can further our understanding of the human disease process and lead to innovative treatment strategies.
Preventing, Treating, and Reserving Diabetic Complications
Chronic elevation of blood glucose levels slowly damages organs and can result in life- threatening diabetes complications. Until prevention or cure of type 1 diabetes is possible, it is critical to pursue research toward preventing, treating, and reversing diabetes complications.
Diabetic eye disease is a debilitating complication of type 1 diabetes and is a cause of vision loss in working age adults. This vision loss is often due to diabetic macular edema (DME), a condition in which fluid leaks from blood vessels and causes swelling and damage to the central retina.
The development of intravitreal anti-vascular endothelial growth factor (VEGF), drug and biologic products has more recently led to improved treatment. Previously, patients might have had to resort to laser treatment procedures in an attempt to preserve some measure of vision. The National Eye Institute-led Diabetic Retinopathy Clinical Research Network (DRCR.net) showed that the anti-VEGF drug, ranibizumab, often in conjunction with laser treatment, is a more effective treatment for DME than laser treatment alone.11 Ranibizumab blocks the function of VEGF, a protein that promotes blood vessel growth. Clinical practice has now changed dramatically - anti-VEGF therapy, where the drug is injected directly into the eye's vitreous, is one of the standard treatments for people with vision loss from diabetic macular edema.
Building on this result, another recent DRCR.net comparative effectiveness trial compared safety and efficacy of three anti-VEGF drugs commonly used to treat DME: Eylea® (aflibercept), Avastin® (bevacizumab), and Lucentis® (ranibizumab). The trial showed that, in people with DME and mild visual impairment, any of the three drugs, on average, improved visual acuity and that the drugs were equally effective. Researchers found no major differences in the safety of the three drugs.12 The costs of these drugs differ widely: based on Medicare allowable charges, the per-injection costs of each drug at the doses used in this study were about $1,960 for Eylea®, about $1,200 for Lucentis®, and about $70 for Avastin®. Many patients required 10-12 injections. Thus, these results offer important data for informing clinical decisions for DME, while having significant cost implications. The study reinforced the previously reported finding that anti-VEGF therapy actually improves vision, as compared to laser treatment that is effective in preventing blindness but does not improve and often somewhat worsens vision in the short term. Improving vision with anti-VEGF therapy can make the difference between people being able to drive or not, which greatly affects quality of life.
Because the study compared drugs from different companies and the results of the recent DRCR.net trial had large cost implications, the Government was in a unique position to support it, as it would not have been conducted by the private sector. Another new clinical trial that would also not be supported by the private sector is the NIDDK's Preventing Early Renal Loss in Diabetes (PERL). PERL is testing whether the inexpensive, generic medication allopurinol, currently used for the treatment of gout, could preserve kidney function in people with type 1 diabetes who are at high risk of kidney disease. If this inexpensive drug proves effective, it has the potential to be the first new therapy to reduce risk for diabetic kidney disease in over two decades. Diabetic kidney disease is a major risk factor for cardiovascular disease (CVD) in people with type 1 diabetes, underscoring the importance of studying new strategies to prevent kidney disease.
Although blindness, amputation, and kidney disease are what people with the disease fear most, CVD is the leading cause of death. It is important to determine when to start prevention efforts in people with type 1 diabetes to reduce their risk of CVD and lengthen their life. The SEARCH for Diabetes in Youth Study is shedding light on this by studying the natural history of CVD and examining CVD risk factors in youth with type 1 diabetes. SEARCH researchers found that youth with the disease, particularly those with suboptimal blood glucose control, had reduced overall heart rate variability compared to youth without type 1 diabetes.13 Reduced heart rate variability is a sign of cardiac autonomic neuropathy, a complication of diabetes that increases the risk of mortality. SEARCH also found that youth with type 1 diabetes had increased carotid intima-media thickness (indicative of the presence of atherosclerosis) compared to youth without type 1 diabetes, and that this association may be attributable to poor blood glucose control.14 These data indicate that this population shows signs of CVD risk early in the course of the disease. To inform future research directions related to CVD in type 1 diabetes, the NIDDK and the National Heart, Lung, and Blood Institute co-sponsored a workshop in October 2014, at which experts discussed research questions that are important to pursue.
Emerging Opportunities in Type 1 Diabetes Research
Building on the recent research advances I have described, the NIH is supporting new and emerging research in type 1 diabetes and its complications. For example, the NIDDK supports behavioral research to identify ways to improve adherence to the difficult treatment regimens required to manage type 1 diabetes. Data from children participating in the SEARCH study indicate that most teenagers do not meet the goals for intensive glucose control recommended by the ADA. Average glucose control is closer to that of the conventional, rather than the intensive treatment group of the DCCT. This information is worrisome because we know that the intensive control group had a dramatic reduction in long-term complications compared to the conventional control group. Thus, it is imperative that research identify ways to help people manage their disease to improve long-term outcomes. Toward this end, the NIDDK is supporting behavioral research studying different age groups - from young children, to adolescents, to adults - because each age group faces unique challenges when it comes to managing the disease.
Since currently clinical research is often costly and time-consuming, the NIDDK is focusing on approaches to streamline and accelerate type 1 diabetes research and make it possible to get answers more quickly. Thus, lack of biomarkers that predict disease progression and response to therapy is a major obstacle to the development and testing of new therapeutic approaches. To overcome this obstacle, NIDDK is fostering creative new research to develop biomarkers for complications and for progressive loss of beta cells.
The NIDDK also remains committed to providing access to research resources that will increase our understanding of type 1 diabetes and its complications. For example, we support distribution of human islets from organ donors and ancillary studies of type 1 diabetes clinical studies and make samples and data from completed studies available to the research community through the NIDDK Central Repositories. These types of approaches reduce duplication, make resources broadly available, and maximize the return on our past scientific research investments. The NIDDK is also supporting training and career development programs to recruit and retain scientists with different areas of expertise whose talents will enhance the type 1 diabetes research field.
Looking forward, the NIDDK support of type 1 diabetes research will continue to be guided by the 2011 Diabetes Research Strategic Plan, which the Institute spearheaded with broad external input. The statutory Diabetes Mellitus Interagency Coordinating Committee (DMICC), chaired by NIDDK, also serves a key function by coordinating activities and reducing duplication across several HHS and non-HHS government entities. Earlier this year, under the auspices of the DMICC, we solicited input from scientific and lay experts about future directions that could be supported with the recent extension of the Special Diabetes Program through FY 2017. Guided by that input, strategic plans, and input that the NIH receives at venues such as scientific conferences and workshops, the NIH is now identifying the most compelling areas of current research opportunity to pursue with the new funds and will ensure that the Program continues its exceptional track record of supporting cutting-edge type 1 diabetes research.
I appreciate this opportunity to share with you these few recent advances, ongoing efforts, and emerging opportunities in type 1 diabetes research. We are grateful for the continued support of the Congress and the Administration that has allowed the NIH to vigorously support research to combat type 1 diabetes and its complications. We look forward to continuing our strong partnerships with patient advocacy groups, research institutions, and our sister Federal Agencies. We also thank all of the clinical study volunteers, without whom the clinical research I described today would not be possible. Working with all of these partners, the NIH remains steadfast in our goals of preventing, treating, and ultimately curing type 1 diabetes.
Thank you, Chairman Collins, Senator McCaskill, and Members of the Committee for your attention. I will be pleased to answer any questions you may have.
1 http://www.ncbi.nlm.nih.gov/pubmed/25562265
10 http://www.ncbi.nlm.nih.gov/pubmed/25141178


With an open view and south exposure this house / villa (town house) of 137 m² (about 1473 ft²), built in 1990, on 3 levels contains 4 rooms including 3 bedrooms, 1 bathroom, 1 shower room and 2 toilets. it is equipped with a living room of 50 m² (about 538 ft²), with dining room, with a fitted, with a terrace and with a parking lot. heating : individual gaz. others : parquet floor.


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What Are the Effects of Law and Order
The law and order approach uses reactive policing, supported by various forms of legislation, to forcibly evict indigenous peoples from public places. Experience in a number of urban centres shows that such policing approaches can only be partially successful and even completely unsuccessful when it comes to eliminating Indigenous public spaces. They are likely to result in temporary or local displacement as full cycles of incarceration, alcohol abuse and social housing continue, and may also violate anti-discrimination laws. Forced physical transfer to remote settlements is equally repugnant and a violation of civil liberties. Fundamentally, any movement of Indigenous peoples from the public spaces they occupy due to conflicting public needs should be led through a negotiation process, regardless of its duration, and supported by a planned set of alternative housing options and services acceptable to all parties (Memmott 2006). Hitler`s glorification of law and order discredited the notion of law and order. The punishment as a normal continuation of the crime was tainted by fascist. In democracies, after World War II (after punishing collaborators, sometimes indiscriminately), anti-fascist parties regarded punishment as legitimate only as "treatment". One lesson has not been learned from Hitler`s experience: punitive laxity breeds political extremism. The far-right parties that emerged in late twentieth-century Europe often arose out of the need for a party in France, the Netherlands, Italy, Norway, and Sweden to express popular sentiments about the Great Wave of crime. The study, published in the Journal of Health Communication, took 313 freshmen and asked them if they saw the top three procedural franchises on network TV: Law & Order, CSI and NCIS. Students were asked how much they agreed or disagreed with statements that examined acceptance of rape myths ("When a woman is raped, she is at least somewhat responsible for things that are out of control"), intentions to obtain consent for sexual activity ("I would stop and ask if everything is okay if my partner does not respond to my sexual advances"), and intentions to refuse unwanted sexual activity ("I would refuse unwanted sexual activity on my date, even if it could destroy the romantic atmosphere"). The concept and exact phrase "law and order" became a powerful political issue in the United States in the late 1960s.
The first prominent American politician to use the term during this period was Alabama Governor George Wallace, who used the term as a political slogan and racist whistle in his 1968 presidential campaign. Other leading supporters included two Republicans, California Governor Ronald Reagan and presidential candidate Richard Nixon. Nixon used the term to attract various demographics, including white working-class ethnicities in northern cities. Nixon sought to discredit the Democratic Party in the eyes of these voters by accusing it of being lenient on crime and rioters. [5] There are also some differences between the method used and the actual method, which limits the application of our results. For example, Kerstholt and Jackson (1998) found that participants who were asked to assess the guilt of the accused after seeing all the evidence had a speed effect when background information was provided, but a primacy effect when no basic information was provided. In our study, participants were not given any basic information about the suspect. In reality, judges in the Netherlands receive the file and then have about a week to prepare the trial (Van der Post & Van Toor, 2019). According to Kerstholt and Jackson (1998), such general information would contribute to a topical effect. In addition, the delay between the submission of evidence and the decision-making process may also affect the potential effects of the contract.
Greater time between different pieces of information presented was associated with an increased speed effect, while greater time between final presentation and recall was associated with a reduced timeliness effect (Insko, 1964; Stout et al., 2005).
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What Are the Legal and Ethical Framework
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Our many years' experience running a nursery is the foundation for your apple growing success. Owing to our know-how, we have been able to increase our yearly production to about 2 million apple trees. We don't just supply our customers with the "apple tree" product but also with the knowledge we have acquired.
We offer the best possible mutations of the classic varieties such as Gala, Fuji, Golden Delicious, Red Delicious and Granny Smith as well as the best seedlings of new and innovative apple varieties such as Redlove, a scab-resistant club variety with red flesh.
Furthermore, we offer different categorisations. In addition to one-year-old trees and Knip trees, we also have Maxi-Knip trees. These are apple trees to which we have awarded our protected "Maxi Knip" Seal of Approval – i.e. trees with at least 12 useable shoots and some other advantages.
We obtain all the grafts we use exclusively from the owners of the variety or mutation, from reliable graft mothergardens or from our own graft mothergardens.
No sapling resembles another. That is why we classify them based on their properties. By doing so, we reach different quality categories.


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Castellanos' 4 RBIs carry Tigers past Pirates
By Adam Berry and Jason Beck
PITTSBURGH -- Nick Castellanos doubled, homered and drove in four runs to back up Jordan Zimmermann's scoreless start as the Tigers beat the Pirates, 7-4, on Thursday afternoon at PNC Park.Castellanos doubled in two runs off Pirates right-hander Gerrit Cole in the fourth inning and ripped a two-run homer to
PITTSBURGH -- Nick Castellanos doubled, homered and drove in four runs to back up Jordan Zimmermann's scoreless start as the Tigers beat the Pirates, 7-4, on Thursday afternoon at PNC Park.
Castellanos doubled in two runs off Pirates right-hander Gerrit Cole in the fourth inning and ripped a two-run homer to left field off setup man Tony Watson in the eighth. Pittsburgh had rallied for three runs in the seventh, pulling within a run, but Castellanos' line-drive shot sealed Detroit's third straight win against the Bucs.
It was the 10th time in Watson's six-year career, spanning 339 appearances, that the typically lights-out left-hander allowed three runs or more in one outing.
"I guess it just reminds you that these guys are human beings and they're not going to have a 0.00 ERA at the end of the season," Pirates manager Clint Hurdle said. "Couple elevated pitches and they made him pay. That lineup can swing the bat."
Zimmermann hasn't given up a run in either of his first two starts with the Tigers, although he had to work his way out of trouble in Thursday's six-inning outing. Zimmermann escaped two bases-loaded jams and stranded two other runners in scoring position. The Pirates finished the game 5-for-16 with men in scoring position, leaving 12 runners on base.
Cole pitched well after an admittedly "rusty" season debut, retiring the first nine Tigers hitters. Pittsburgh's ace allowed two runs on four hits and a walk while striking out five over six innings.
"I was much sharper today. Stuff was much more defined. We were able to work efficiently," Cole said. "We were able to get strikeouts when we needed to. It's just a good feeling when you can walk away knowing that you've improved from the last start."
MOMENTS THAT MATTERED
Zimmermann works in traffic: Zimmermann hasn't allowed a bases-loaded walk since 2011, but he came within a ball of doing so twice in the fifth inning following three singles. Starling Marte worked the count full before popping out to second. Gregory Polanco, who had a 3-0 count, took a strike before popping out to end the threat.
"I couldn't locate the fastball for whatever reason and fell behind," Zimmermann said. "My slider was good and I can throw it whenever I want. I went with that. And then 3-1, bases loaded, I went with a backdoor slider and got him to pop up. Most guys, the heater's coming 3-1, and they go with their best pitch. But when you're comfortable throwing your slider and you can throw it for strikes when you want, why not go with it?"
Who's on first? Cole cruised through three perfect innings on 34 pitches to begin the game before running into trouble in the fourth. With two outs and Justin Upton on first base, Cole fired a pickoff throw to John Jaso at first base. Problem is, Jaso was playing behind the runner with a full count, so the ball skidded into foul territory and Upton wheeled around to third. Cole then walked J.D. Martinez, and Castellanos doubled home both runners.
"It was just a lack of communication on our part. We didn't communicate," Cole said. "I thought in the situation there with two outs, I might be able to catch Upton sleeping or at least keep him honest. ... I didn't think it affected the next at-bat."
Close call: Cole narrowly avoided a serious injury during the sixth inning, taking a glancing blow off the top of his head on Zimmermann's liner back up the middle. It knocked off Cole's cap on the way to center field for a single. Cole escaped unharmed, remained in the game to finish the inning and was pinch-hit for in the bottom of the frame. More >
Relay out: The Pirates had a couple threats going against the Tigers' bullpen Thursday, and they could've had a bigger one in the eighth inning if not for an out at the plate on a relay from right-center field on Andrew McCutchen's double. Tyler Collins' throw from deep center gave Ian Kinsler time to relay to Bobby Wilson, who tagged Jaso just before he touched home plate. The play not only prevented a run, it saved precious pitches for Mark Lowe, who recorded for outs pitching his third game in four days. More >
"It's 10 games into the season. If this was game 160, maybe. But it's only 10 games." -- Josh Harrison, on the Pirates' struggles with runners in scoring position
"It's important, very important. This is a good team. They battled. They pitched well. Their bullpen is solid. And they can run. Coming in here and getting two is huge." -- Castellanos, on taking two from the Pirates in Pittsburgh, and three of four in the home-and-home series
SOUND SMART WITH YOUR FRIENDS
Zimmermann hasn't issued a bases-loaded walk in 131 starts since Aug. 28, 2011, when he walked Cincinnati's Fred Lewis to drive in Ryan Hanigan. He hasn't given up back-to-back walks in an inning since the seventh inning of a May 6, 2012, start against the Phillies, a span of 125 starts.
Tigers: The three-city road trip continues in Houston, where the Tigers open a three-game series against the Astros on Jackie Robinson Day on Friday at 8:10 p.m. ET. Mike Pelfrey will try to rebound from his tough Tigers debut last weekend while the lineup takes its swings against Astros ace Dallas Keuchel, making his first home start of the year after going 15-0 at Minute Maid Park last season.
Pirates: Left-hander Jeff Locke will make his second start of the season as the Pirates welcome the Brewers to PNC Park at 7:05 p.m. ET on Friday on Jackie Robinson Day. Locke put together a solid season debut, holding the Reds to one run on seven hits over six innings. Last season, the lefty went 3-2 with a 3.45 ERA in five starts against the Brewers.
Watch every out-of-market regular-season game live on MLB.TV.
Adam Berry is a reporter for MLB.com. Follow him on Twitter at @adamdberry. Jason Beck is a reporter for MLB.com. Read Beck's Blog, follow him on Twitter @beckjason and listen to his podcast.


Boppin' and Blog Hoppin': Day Eleven!
First Splatbook you begged your DM to approve.
Should we explain this one? In the world of today, splatbooks would be equivalent to DLC for a video game. They were slimmer books that had laminated or vinyl covers–hence the "splat" when you threw them on a table. The oldschool 2e ones had these gorgeous faux-leather situations going on that captivated me as a young man. I remember parking myself in the stacks at the Borders…B. Dalton? I think B. Dalton in the Casper mall and reading through the Psionics Handbook for the first time in. Incredible stuff.
Again, though, I was usually the DM so begging came -to- me, not from me. When I first started gaming with the guys I'd play with through most of high school, I rolled a Firbolg. I don't think I needed to convince them of this, though; I don't even think I owned the Humanoid Handbook at the time, so they probably put it in my hands. I also believe that party included a dinosaur-man and a flind, so we weren't really a Fellowship-style group.
Online-gaming-wise, I tended to find a solid group of dudes and primarily work games with them, meaning the accepted materials were usually pretty set. Back in the days of the Pits of Evil, most of what we used was homebrewed, because that was much more of a thing in 3.x than 4th. I think it's helped me as a player that I'm never a powergamer and rarely predictable, so if I want access to a new book it's so I can make a paraplegic centaur relying on an intricate latticework of unseen servants to cart his otherwise immobile horsehalf around the dungeon, while he lays about himself with a flail made from the plaited manes of the three sisters he watched slaughtered as a child. Someone on the other side of the table is probably building something worth considerably more concern.
Disarming on a…I believe it was a Wand save?…proved damn useful given that things with weapons to strip weren't often well-suited to hold onto them!
true. well at least it wasn't a flumph!
Oh man, I remember reading the…second Monstrous Compendium?…and getting to the flumph. Which, to be fair, isn't -that- much more ridiculous than darkmantles, piercers, cloakers, etc. About halfway through college my parents scored an incredible box of old DnD stuff, including the Expedition to the Barrier Peaks. Finally reading that helped Flumphs (and Froghemoths, and a dozen other fellers) make much more sense. Incredible approach to limiting player information as well.


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Big businesses could be prosecuted for paying contractors late
PUBLISHED:	 09:08, Wednesday, 19 June 2019 | UPDATED:	 12:02, Wednesday, 26 June 2019
By Jyoti Rambhai
Editor of Modern Work and My Money, a finance magazine for the self-employed.
Large businesses could be fined, and their directors even prosecuted for failing to pay freelancers and small businesses on time, the Department for Business, Energy and Industrial Strategy (BEIS) announced today.
The consultation response, unveiled by small business minister Kelly Tolhurst, proposed measures to improve payment culture and increase transparency.
One of the proposed measures is to take a tougher approach to company boards that fail to report their payment practices. In serious cases, that could mean using existing legislation to prosecute company directors.
BEIS has also proposed giving new powers to the small business commissioner, which include compelling the disclosure of payment terms and practices, imposing financial penalties and binding payment plans on large businesses found to have unfair payment practices.
Another suggestion is to move the voluntary code of best practice – the Prompt Payment Code – to the small business commissioner. BEIS claims that this will put all the tools to tackle late payment under one organization and will ensure the commissioner has the powers to affect culture change.
Other proposals in the report include a new fund to encourage businesses to use technology to simplify invoicing, payment and credit management.
Tolhust said: "The vast majority of businesses pay their bills on time, with the amount owed in late payments halved over the last five years. But as a former small business owner, I know the huge impact a late payment can have on the ability of a small business to plan, invest and grow.
"Small businesses are the backbone of our economy and through our modern Industrial Strategy we want the ensure the UK is the best place to start and grow a business. These measures will ensure that small businesses are given the support they need and ensure that they get paid quickly – ending the unacceptable culture of late payment."
IPSE's deputy director of policy, Andy Chamberlain, said: "The late payment culture that so many big businesses get away with needs to change. For the two thirds of self-employed people who experience it, late payment means no income, empty bank accounts, debt and possibly destitution. Today's announcement is a welcome step in the right direction."
Green light given to small business commissioner to clamp down on late payment
'The dog ate my invoice' and other unbelievable tales of non-payment
Government backtracks on class 2 NICs abolition


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Sanatoriums,
Holiday camps,
Country tourism,
SPA & Beauty,
Event's calendar
2019 2020 2021 January February March April May June July August September October November December
M T W Th F Sa Su
Pubs,
Palanga / Entertainments /
Sightseeing (Palangoje, Šventojoje, Karklėje, Melnragėje, Giruliuose)
All Sights Cognitive routes
Palanga botanical park
(Sights)
Palanga Botanic Park is one of the most beautiful, best preserved and maintained parks on the Lithuanian coast line. It was founded in1897 by Count Feliksas Tiškevičius. More
Address: Vytauto g. 15,
The palace of count Feliksas Tiskevicius (now Museum of Amber)
The neo-renaissance palace was built in 1897 according to the project of the German architect Franz Schwechten. The palace was restored in 1957 (author A. Brusokas). More
Birute hill
Relict dune marked on all larger-scale maps since the 17th century as the highest dune on the Palanga seashore. More
J. Basanavičius Street
Earlier this street was called Tiškevičius Street or Boulevard. In the summer of 1923 Dr. Jonas Basanavičius visited Palanga. More
Address: J. Basanavičiaus g.,
Sea Bridge
Getting to Palanga in the 19th century was quite some trouble to the holidaymakers. Having arrived to Liepaja or Klaipėda they had to continue to Palanga by horse-drawn carriages. More
The Seaside Regional Park
The Seaside Regional Park is situated in the south from the Palanga Botanical Park and stretches to Klaipėda city. More
Samogitian Alka
In XIV c. on the top of Birute hill was arranged the place for astronomical observations. More
Amber Workshops
Palanga Guild of Amber Craftsmen is a public organisation founded in the end of 2000 and uniting 26 artisans of amber. More
Address: Vytauto g. 21/ S. Dariaus ir S. Girėno g. 27,
Ivera Mother of God Orthodox Church
The orthodox parish in Palanga was founded in 1995. In the beginning, it was hosted in one room of the Russian school. More
Sculture "Rebeka"
"Rebeka" ("Woman Carrying Water"), by the French sculptor Hubert Louis-Noel, originally stood in the Vilkenas palace park (Silute region). More
Sculpture, dedicated to M. K. Ciurlionis' triptych "Signatures"
This monument, designed by the sculptor Steponas Sarapovas and the architect Algis Knyva, is in the north of the park, to the right of the main park entrance near Dariaus and Gireno street. More
Sculpture "Eglė the Queen of Serpents"
This is one of the most popular sights of the park and one of the prettiest and best-known sculptures in Lithuania. More
The Lurdas
After the construction of the park was finished, Count Tiskevicius' wife Antanina decided to build the Lurdas. All the stones used are unprocessed and are held together by cement. More
Sculpture "Jesus giving a blessing"
This sculpture by Stasys Zirgulis stands across from the Tiskevicius palace, on the botanical garden's large terrace . More
Sculpture "For you, Birute"
This sculpture was created by the artist Konstancija Petrikaite-Tiuliene and erected in 1965. It stands on a stone at the foot of Birute's hill - the symbolic eternal resting place of Princess Birute. More
A chapel on Birute hill
In 1869 was built a chapel by project of architect K. Majer. In 1976 stained-glass windows were arranged in this chapel (author L. Pocius). At the foot of a hill is a sculpture of sculptress K. More
Zemaiciu Alkas (Sventoji)
In XIV c. on the top of Birute hill astronomical observations were carried out. More
The Fisherman's Daughters
In the dunes, near the gates of Šventoji port, there is an impressive (about 4 meters tall) sculpture The Fisherman's Daughters. More
"Madzuchai" (The Valley of Singing Stones)
The project "Madzuchai" (The Valley of Singing Stones) being implemented next to Palanga resort town attempts to develop a unique attraction facility for local and inbound tourism. More
Kretinga Manor
Kretinga Manor was built in the 15th – early 16th century. Count Juozas Tiškevičius bought it from Mikalojus Zubovas in 1875 and it became the family's residence. More
Address: Vilniaus g. 20,
1 - 20 From 35


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Dancehall, News, Trending
Jah Cure Addresses Knocked Out Video "I Didn't Get Beaten Up"
by S. Leslie November 15, 2016
Jah Cure has stepped forward to address a viral video showing him getting knocked out at a hotel in Bahamas last weekend.
The one-minute clip shows the reggae singer in a fight with two to three other men and then at the end of the video you can see someone laying on the ground unconscious that folks are saying is Jah Cure. But here is where things got interesting, sources are saying that Cure and another man was fighting because the singer was having an affair with the man's wife.
In a video posted on Instagram, Jah Cure clear up all the rumors telling his fans that he was simply trying to be a peacemaker and almost got himself hurt. He also noted that none of the other rumors are true.
"So yes people real truth now," he said. "See the passa passa that you see circulating on the internet, that's dirt… If it was a truthful dirt then maybe I wouldn't be on the internet now explaining to you. I didn't get beat up, I wasn't in a fight, I was just trying to part a fight between two men and one of them was drunk and acting stupid."
More Jah Cure News
Jah Cure Announces "Royal Soldier" Album Release Date
Reggae Star Jah Cure Leads Nairobi City Cleanup This Weekend While On Royal Soldier Tour In Africa
Jah Cure and Damian 'Jr. Gong' Marley Drops New "Marijuana" Anthem


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Boston's First CDO Can Set Example for City Governments
By Lou Jordano, June 9, 2016
At the end of May, the city of Boston named Andrew Therriault as its first CDO—chief data officer. Therriault, former Director of Data Science for the Democratic National Committee, comes with an impressive background. He has a B.A., M.A. and PhD. in politics from NYU. Before joining the DNC, he served as senior data scientist with Greenberg Quinlan Rosner Research, whose client list includes global companies, advocacy groups, and political organizations as well as former presidents. So, he's certainly qualified.
As mentioned in a prior blog, a lot of the people we talk to in large enterprises are CDOs. Or, if they don't have that title, they have those responsibilities, which Debra Logan of Gartner describes as the "glue between data strategy and metrics." Not many have Therriault's credentials. But what many have that Therriault may not are the "street smarts" that come with waging turf warfare. Whenever organizations undergo large scale changes—like operationalizing an effective approach to Big Data—resistance and turf battles inevitably emerge.
Nevertheless, Therriault is a great choice for the city's first CDO. Boston already has a reputation as a leader in data-driven government. It's not new to analytics and decisions based on them. And it's not afraid to use technology in unusual ways to solve problems. Just think back to when Boston employed Code for America's "adopt-a-hydrant" app to enlist residents to help keep fire hydrants uncovered during heavy snow storms.
What kind of data ecosystem and tools will Therriault inherit? I don't care about what his first few weeks on the job are like. But what about the first few months?
The CDO is a new position, whether it's in the public or the private sector. To some extent—for better or worse—they're making it up as they go along. Someone with Therriault's pedigree knows exactly how things should work. But as the CDO, his main job will be describing a vision that everyone can buy into and that he'll have the resources to implement.
In the private sector, many CDOs inherit an immature and fragmented data ecosystem. Frequently, this situation is compounded by the proliferation of analytics tools across an organization and various shadow IT efforts that involve business units creating their own databases, with no governance or oversight. Newly-minted CDOs may also need to close a Big Data skills gap, re-architect various processes that cut across business and functional units, and foster a data-driven culture. All of these challenges surely have analogs in the public sector.
On the same day that Boston announced Therriault's appointment, Attivio published the results of a survey on the often huge disconnect between organizational excitement over Big Data and the ability to execute. For example, the survey found that while 98 percent of respondents stated their firms were committed to grounding their decision-making in data, only 23 percent felt that they were extremely successful in making data-driven decisions.
So, although I'd like to wish Mr. Therriault smooth sailing, I know that's not realistic. Instead, I'll wish him a successful data-driven voyage.
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