The Tench label is definitely about quality more than quantity, with a mere seven releases over the last five years. All are worth attention. The last before the current release was Porya Hatami's Shallow, over a year ago. The latest is from label head M. Ostermeier, and its title, Still, succinctly yet accurately captures its mood.
Listening to this album the first half dozen times I found myself having to repeatedly reorient my horizon of expectation despite the apparent consistency of its palette. The album opens with an oscillating hum, over which a slow piano meditation begins, soon accompanied by a background of small creaks and rustles. The sound put me in mind of the intimacy of Nils Frahm's Felt, in which the creakings of the piano itself are an important presence that adds to the emotional intimacy. The piano presence on Still, however, soon turns out to be starker, more distant, more austerely and repetitively meditative. As the hum continues to anchor the track I begin to think more of Alva Noto and Ryuichi Sakamoto's collaborations, in which the intersection of laptop and piano is explored. But this reference too passes. Despite the oscillating wave, the small scurryings, the piano figures, there is a deep stillness at the heart of the track captured in its title, "Stasis." Single piano gestures cluster in patterns but the space between them precludes momentum; after a while I am reminded more of releases such as Kenneth Kirschner's Twenty Ten or Thomas Köner's Tiento de las Nieves, where each piano sound is held up for contemplation rather than taking its place in the moving walkway of melody.
The second track picks up almost seamlessly from the first, except that the hum departs and the rustlings and scrapings pick up pace, clearly much more now than mere environmental creaks and whispers. The balance of the elements is shifting. The piano is as stark as ever but behind it a small world of hurried motion flutters in parallel. The track is called "Division." "Hang," a brief interlude, keeps only the piano, which takes on a more plaintive voice. After the uncompromising starkness of the opening three tracks, I am ready for something to shift, and shift it does.
"Counterpoise" is hardly brash, but after the stillness that precedes it, it arrives with startling vivacity. An electronic pulse with a skittering beat replaces the piano, and at first it feels like the start of a different album, lighter and more motile. Before long, however, the piano is reintegrated, and so are the background tappings, but now clustered rhythmically and given varying dynamics, like a hesitant accompanist on a typewriter. Clicks and pops add to the unsteady rhythms, and the overall effect is quite delightful. "New Lights" drops the new electronic movement to a dappled whisper over which it explores more hopeful-sounding chords, before "Congruence" pairs the piano once more with a prominent hum. "Inertia" continues that hum and has small foreground sounds visit it – by now the sense of inversion is complete, as if the small background rustles of the first track have by now become the actual narrative. This is the longest track and it has returned us to a deep sense of stillness. The closing track, "Parity," sounds more lugubrious than any track so far, ominous in tone, the piano questioning and leaving us hanging for a response before resolving on a resigned note and then fading out with the echo of a more ambiguous chord.
There is an almost mathematical sense of combinatorial possibilities about the whole album, as each track reveals subtly different combinations of a basic set of elements, adding and subtracting to create slight shifts of mood, pitting light against shadow, stillness against motion. Yet there is nothing mechanistic about the sounds, which evoke a contingent, human world and invite a meditative attentiveness to each note, each rattle, each resonance. It is an album that calls for patience and in return casts a slow spell, drawing the listener through a slowly shifting landscape of thoughtful sound. Another fine release from Tench, Still is recommended for close listening. Order it here.
One of my favorite albums this year. Thoroughly enjoyed your treatment of it. All the best – Stationary Travels (Brian).
Thanks! Yes, it's a very nice release.


text:
function (add_custom_command)

    message (STATUS "Called add_custom_command")
    _add_custom_command (${ARGN})

endfunction ()

redpajama_set_name: RedPajamaGithub


YAOUNDE, The United States has announced it is cutting some security assistance to Cameroon following allegations of human rights violations allegedly committed by the Cameroonian military.
Colonel Didier Badjeck, a Cameroonian military spokesperson, criticized the Amnesty report, saying his country's military is professional.
Officials in Yaounde have not commented on the U.S. move. Coinciding with the decision was a charity effort at a school in Fotokol, on Cameroon's northern border with Nigeria. At the school, students were receiving school equipment and medication from the Rapid Intervention Battalion, an elite corps of the Cameroon army.
Teacher Epoum Mahaman says the move was encouraging to the children, who have suffered attacks by militant group Boko Haram � such as the burning of schools, kidnapping of teachers and killing of some of their parents and relatives.
Military colonel Alain Mvogo says the troops were handing out the gifts because the military not only fights wars but also reconciles people and strives for peace.
Fotokol is one of the areas cited last year in the Amnesty report.
Amnesty said numerous human rights abuses were committed by Cameroon's military in its crackdown on Boko Haram, including the killing of dozens of civilians, torture, and arbitrary mass arrests.
The Nigeria-based Islamist terrorist group has been recruiting fighters in Cameroon, using them as spies and informants in areas it does not know.
Boko Haram, whose name in the Hausa language roughly translates to "Western education is a sin," has attacked mosques and churches on Cameroon's northern border with Nigeria, in addition to schools.
Pascal Tantoh is a 31-year-old teacher who fled the fighting between the military and separatist forces in the English-speaking northwest region. He said the U.S. decision to scale back security assistance indicates that America is finally realizing what Cameroon has suffered.
Businessman Victor Enow said he was targeted by Boko Haram terrorists in the northern town of Mora while returning from a business trip to Nigeria. He says the United States should have ensured peace returned to Cameroon before considering if it could withdraw its support.
Peter Henry Barlerin, U.S. Ambassador to Cameroon, met with Cameroon's government spokesperson Rene Emmanuel Sadi after the cut was announced. Barlerin said despite the announced reduction in military aid, relations between the two countries remain good.
Besides the U.S., other countries that help Cameroon militarily, and which Cameroon counts on, include Israel, France, Germany and China.
Human rights groups have reported that Cameroonian security forces have targeted civilians in the far north and in the country's unstable southwest and northwest regions, where the military is battling English-speaking separatists fighting to create a breakaway nation called Ambazonia.


Yesterday I shared some information discussing my favourite sleep boosting app – F.Lux; you can read all about this here. Today, I wanted to share some information regarding a simple function on our I-phones that will also help promote a healthier sleep.
Almost all of our gadgets will emit a blue light and whilst it's OK to absorb this blue light during the day, exposure to blue light at night can interfere with our sleep patterns. You can read all about this here.
Blue light interferes with our production of melatonin, a powerful sleep hormone and as such, staring at our phones (as well as computers, laptops and televisions) well into the evening, can make it difficult for us to fall asleep.
The team at Apple are onto most things and are incredibly receptive to consumer demand, hence they recently introduced "night shift"; a simple function built into our I-phone that switches the blue light down a notch, substituting it with a warm amber light (just like a fire would in the caveman days), helping to promote healthy melatonin levels and consequently, a healthier sleep.
Who has access to "Night Shift"? Everyone with an I-phone 5 model or later who has installed i.OS 9.3 or later.
Because there is a function in built into our phones, there is no need to download an app from the app store. Just follow these six simple steps, it's as easy as that!
Ensure your iPhone or iPad software has been updated to i.OS 9.3 or later.
Open Settings. Select Display & Brightness.
REMEMBER: Whilst this is a great tool to help you reduce your blue light exposure, switching off your electronic devices at least 1 hour before bed is always recommended ;).
Don't have an I-phone? F.Lux is available for Android download. You can read more about F.Lux here.


Enjoy the top 2 famous quotes, sayings and quotations by Camillo Golgi.
Want to see more pictures of Camillo Golgi quotes? Click on image of Camillo Golgi quotes to view full size.
"Which brings us to a little book that may provide a clue to the cure. My wife got it as a gift from" — Anonymous.


text:
Jazz-Knicks Line at New York -6.5
The Jazz-Knicks line was listed at New York -6.5 with a total of 211 at Sportsbook.com.
The Knicks look to win back-to-back games for the first time since the blockbuster trade that landed Carmelo Anthony in New York, while the Jazz hope to get Tyrone Corbin his third win in 10 games since taking over for Jerry Sloan, when the teams meet Monday night at Madison Square Garden.
Utah's landslide has dropped it to 10th in the Western Conference and 1½ games out of the eighth spot. The Jazz have won four straight against the Knicks, but this time will be without Deron Williams, who was recently traded to the Nets, and Paul Millsap (17.1 PPG) who injured his knee in Saturday's 109-102 win against the Kings. The Jazz will need Al Jefferson (18.2 PPG) to continue his exceptional play. He is averaging 26.1 PPG over his past eight games. Jefferson hasn't had much success in the past at the Garden (11.3 PPG), but that may change with the undersized and lackluster defense of the Knicks' frontcourt.
The Knicks are hoping to get Chauncey Billups (17.0 PPG) back after missing three games with a quad injury. Billups has averaged 23.0 PPG with New York and would love to help the team win back-to-back games for the first time since winning three in a row from Feb. 12-23. Carmelo Anthony (25.1 PPG) said he is ready to go after being poked in the eye in the 92-79 win Sunday over the Hawks. Anthony had a poor game, scoring only 14 points on 6-of-18 shooting. Anthony averaged 28.2 PPG as a Nugget in 13 career games against the Jazz. The Knicks also may be getting back two key reserves, Ronny Turiaf and Bill Walker, who have been slowed down by sore knees.
The Jazz are 8-23 ATS in their past 31 games and 10-17 ATS versus teams with a winning record. Utah also does not like getting in shootouts where it is 14-20 ATS against poor defensive teams (allowing 99.0 PPG or more) and 12-18 ATS against good offensive teams (score 99.0 PPG or more). New York, on the other hand, is 18-10 ATS against teams who score 99.0 PPG or more and 18-8 ATS against teams with a winning record. The Knicks also are 10-3 ATS coming off an upset win, 7-1 ATS against Northwest opponents and 10-3 ATS playing on back-to-back days.

redpajama_set_name: RedPajamaCommonCrawl


In a show of support, Russian President Vladimir Putin has sent a letter of condolence to UK Prime Minister Theresa May, according to a statement published on the president's website.
"This crime shocks [us] with its cruelty and cynicism," Putin said, adding that the world should join efforts in the fight against global terrorism.
The president also expressed his condolences to the families of the victims and wished a speedy recovery to all those injured in the attack.
Putin's French counterpart, Emmanuel Macron, reiterated his country's commitment to its long-standing ally.
"In the face of this new tragedy, France is more than ever at Britain's side. My thoughts go out to the victims and their loved ones," he wrote on Twitter.
At least four French citizens were injured in the attack, Jean-Yves Le Drian, minister of Europe and foreign affairs, later said in a statement, as cited by FranceInfo.
German Chancellor Angela Merkel said that she learned about the attacks with "grief and dismay," her spokesman, Steffen Seibert, tweeted.
"Today, we are united across all borders in horror and sadness, but equally in determination. I stress for Germany: in the fight against all forms of terrorism, we stand firmly and decisively at Britain's side," Merkel said.
"After a dreadful night in London: all our thoughts are with our British friends and this wonderful, brave city," German Foreign Minister Sigmar Gabriel said.
Belgian Prime Minister Charles Michel also took to Twitter to show support for people in the UK.
"A new tragedy in London, we all stand with UK," he wrote.
Italian Prime Minister Paolo Gentiloni called for a uniting of efforts in the fight against terrorism.
"London is once again under attack. Solidarity with the British Government and [let's] joint efforts against terrorism," he wrote.
Spanish Prime Minister Mariano Rajoy said he is following the information about London attack "with sadness," also expressing his solidarity with the families of the victims in the assaults.
"Our solidarity and support to the authorities and to the British people," he wrote.
US President Donald Trump and Vice President Mike Pence also expressed condemnation of the assaults in Twitter posts.
The prime minister of Canada also expressed his condolences, noting that he is monitoring the situation.
Australian authorities, including Prime Minister Malcolm Turnbull and Foreign Minister Julie Bishop, said they have been briefed on the attack and stand firmly with the British people.
Turnbull later confirmed that two Australian citizens were affected by the tragedy, without providing details.
"Shocking and anguishing," is how the Indian prime minister described the attack.
"Escalation of indiscriminate and chain terror attacks around the world is a warning sign for the international community," Iranian Foreign Ministry spokesman Bahram Ghasemi said, condemning the attack.


text:
North Glendale Hts KinderCare
All Centers > Daycare In Glendale Heights, IL > North Glendale Hts KinderCare
Wendy Pearson, Center Director
2264 Bloomingdale Rd Glendale Heights IL 60139
(630) 980-8222 Contact this center
Show other centers nearby
Elementary Schools Bussed To:
DuJardin, Winnebago, Blackhawk, Reskin, G Stanly Hall, Glenhill, Pheasant Ridge, Churchill, Forest Glen, St. Matthew's, Erickson
Our center is accredited by NAEYC.
Welcome to North Glendale Hts KinderCare
Welcome to North Glendale Heights KinderCare! Our locally based staff knows that North Glendale is a great place for families, and we work hard to make our center the perfect place for early childhood education. You'll find a carefully planned program of academic work here, along with beginning and advanced music classes--plus plenty of fun activities! Our staff is dedicated to helping children develop confidence for life.
Our classrooms are places to thrive!
In our safe and healthy classrooms, your child will be engaged in learning experiences that meet them where they are, both socially and academically. With fun daily activities, passionate teachers, and great friends, a lifetime of confidence starts here. Contact the center director to learn more about our child care options and schedule a tour!
Meet Wendy Pearson, Our Center Director
At KinderCare Since: 1993
Education: Associate's Degree in Early Childhood
Favorite Children's Book: Abiyoyo
Meet Wendy Pearson! She is the Center Director at North Glendale Hts KinderCare in Illinois. Wendy attended Triton College, where she earned an Associate's Degree in Early Childhood. She has been with KinderCare since 1993, and before that she was a teacher and an assistant director. "Never give up on what you really want to do. The person with big dreams is more powerful than one with all the facts." - Albert Einstein. Outside of work, Wendy enjoys bowling, traveling, going to hockey games, and spending time with family and friends.
North Glendale Hts KinderCare Programs
AMERICA'S MOST ACCREDITED
We're so proud!
Nationally only 10% of daycares are accredited - nearly 100% of our learning centers are. That's a big difference, and that means KinderCare kids are getting the very best. Here's why.
SCHOOL-READY
What Learning Looks Like
Our talented early-childhood teachers set kids down the path toward becoming lifelong learners in a positive, safe, and nurturing environment.
Infant Programs (6 weeks–1 year)
Leaving your baby in someone else's care is a big step. Everyone at our centers—most importantly, our naturally gifted infant teachers—will work with you to make sure the transition goes smoothly. When you step into our infant classroom, you'll see how much we want your infant to feel safe, loved, and ready to explore their world.
Toddler Programs (1–2 Years)
Everything in our toddler classroom is designed for little explorers. That's because a lot is going on at this age. When your child is wandering all over the place, that means they're learning and discovering new things every day. We'll help them explore their interests (and find new ones!) as they play and learn.
Discovery Preschool Programs (2–3 Years)
This age is filled with so much wonder and curiosity. That's why we offer a ton of books and toys and bring artwork down to kids eye level. Children in discovery preschool also begin to learn how we all work together in a classroom. Simple math and science, pretend play, and group play help them get used to a more structured school setting.
Preschool Programs (3–4 Years)
This age is all about expression, when kids really start to form their own ideas about what they want to play and how they want to create. Every day in our preschool classroom, your child will explore science experiments, create artwork, and play pretend—all the skills needed for their big next step: kindergarten!
Prekindergarten Programs (4–5 Years)
When you walk into one of our pre-K classrooms, you'll see artwork and writing displayed around the room. Labels are everywhere to help kids connect letters with words. You'll also see pictures on the walls that reflect the families in our community. Your child will also deepen their knowledge in language, math, science, Spanish, and social skills.
Before- and After-School Programs (5–12 Years)
You can count on us to provide reliable care for your school-ager while you're at work, with safe transportation from our center to your child's school and back! Whether your child wants to start a drama club, build a volcano, or create a comic book, they will have a place to follow their dreams. Your child will start and end the day with a whole lot of fun!
School Break Programs (preschool, prekindergarten, and school-age)
Winter break, spring break, summer break—when school's out (but you still need to work), you can count on KinderCare to provide a safe and supportive learning environment that's focused on fun. We welcome children ages 5–12 during school break times and make sure they have a sensational, screen-free experience they won't forget.
Learning Adventures - Enrichment Program
Cooking Academy™ (3 – 12 Years)
In Cooking Academy, kids learn new recipes from cultures around the world and develop a healthy relationship with food. They'll whip up everything from Southwest rainbow lettuce wraps to pumpkin muffins, building their skills in STEM, communication, and more along the way. And yes—little chefs get to eat their culinary creations!
Music Explorers™ (2 – 4 Years)
KinderCare families are already giving a standing ovation to our newest Learning Adventures program: Music Explorers! Kids will learn to sing, move, listen, play instruments, and even create their own tunes. Our original curriculum blends math, science, social studies, literacy, and mindfulness (think yoga!) for a uniquely KinderCare way of learning the foundations of music.
Phonics Adventures® (2 – 4 Years)
Learning how to read is a whole lot of fun at KinderCare! We help kids grow to love books and words (and get ready for kindergarten) in our Phonics Adventures program. From discovering the basics of vowels to practicing poetry, kids learn all about letters and sounds in small-group lessons made just for their age group. (Bonus: Kids who attend our phonics program are more prepared than their peers for school—and we have the data to prove it.)
We're the only company in early childhood education to select teachers based on natural talent. Being a great educator isn't enough though. KinderCare teachers are also amazing listeners, nurturers, boo-boo fixers, and smile-makers. Put more simply, we love our teachers and your child will, too.
Meet just a few of our amazing KinderCare teachers!
A KINDERCARE TEACHER WITH
An Artist's Heart
"My classroom is full of art!" says Mary Annthipie-Bane, an award-winning early childhood educator at KinderCare. Art and creative expression, she says, help children discover who they really are.
We put our best-in-class teachers in a best-in-class workplace. We're so proud to have been named one of Gallup's 37 winners of the Great Workplace Award. When you put great teachers in an engaging center, your children will experience an amazing place to learn and grow.
Don't take our word for it. Hear what our families have to say about our amazing center!
I am a fellow parent whose child attends KinderCare and I wanted to say that I think this daycare does an amazing job with the children from the way they run the facility and programs to how they deal with the children. My son, who recently turned two years old in May, but has been attending since the age of one year old has achieved so much growth since become a student here. Just him being able to be surrounded by fellow peers have done so much for him. My son has also been given the chance to learn all sorts of things and partake in all kinds of fun activities. I am truly grateful and feel safe knowing that my child is in the hands of caring people.
Donnisha B. - KinderCare Parent
KinderCare has been such a blessing to my children and I. My children absolutely adore their teachers and I know their teachers genuinely care about them. Ms. Wendy their Director , Ms. Cathy, Ms. Kelly the School- age teacher, Ms. Toni, Ms. Toya, and Mr. Frank are just a few, too many names to mention. My son has been at the center since he was three and my daughter since she was nine months old. Now they are six and three years old. These teachers really helped my children advance and prepared my son for Kindergarten. I really appreciate all their hard work and commitment to the children.
Bernice L. - KinderCare Parent
"Words alone can't begin to thank you for all of the years of love and care you have given Melania and myself. We are very grateful to have had your faces to greet us every morning for the past 4 years. I just wanted you to know how much I appreciated all of the advice you have given me to help me become a good mom. Without you guys I don't know how well we would have made it. You helped me in good times and bad and gave me the extra confidence I needed to go on. You were always there to tell me everything will be okay. Thanks for helping give Melania the courage to be proud of who and what she has become, a fine young lady. I was crying the first day we came in and the day that we leave. Thank you for everything....!"
Magdalena - KinderCare Parent
"Since my son started at KinderCare, I have been amazed by the changes in him. He has become more sociable and less shy around others. He is always coming home excited to share the new things he has learned that day, whether it be a new song, nursery rhyme or how high he can count now. ... I think he will adapt quickly to kindergarten when he goes because of the atmosphere and the expertise of his teachers. They make learning fun for the children. He adores his teachers, and they are so good to him. I have no doubt that they genuinely care for him and his future. I can't get over how much he has learned and grown as an individual since he has been at KinderCare. You and your staff have been nothing but wonderful, caring, supportive people to my son and my family. It is extremely hard being a working mother, and in my opinion since I can't be home with him, the Glendale Heights KinderCare is the next best thing."
Amanda - KinderCare Parent
If you have a story about your experience at KinderCare, please share your story with us .
Who Are KinderCare Families?
They hail from hundreds of cities across the country from countless backgrounds, and proudly represent every walk in life. What our families have in common, though, is the want to give their children the best start in life. We are so proud to be their partner in parenting.
Hear from just a few of our amazing KinderCare families.
A Globe-Trotting Family Finds A
Home in Houston
Four young children, four different passports, two languages, two full-time jobs…oh, and a few triathlons thrown in for good measure. Meet the globe-trotting Colettas—a family on the go.
What accreditations does KinderCare have?
We are your trusted caregiver. Our centers are state-licensed and regularly inspected to make sure everything meets or exceeds standards, including child-to-teacher ratios and safe facilities. Our centers aren't just licensed—most are accredited, too! Find out more.
Do you offer part-time schedules at North Glendale Hts KinderCare?
Everybody's schedule is different. We're happy to offer quality, affordable part-time and full-time childcare. Drop-in care may also be available. Reach out to your Center Director to learn more.
How does naptime work at North Glendale Hts KinderCare?
Our teachers meet every child's needs during naptime. Our teachers know how to get babies to nap. In fact, they are pros at getting children of any age to nap. Visit our article on "10 Ways We Help Kids Get a Great Daycare Nap" to learn more.
Do you support alternative diets?
We strive to be as inclusive as possible. To that point, we provide a vegetarian option at mealtime, take care to not serve common allergens and can adapt menus based on your child's food sensitivities. If your child has additional needs, we'll work with you to figure out a plan.
Are meals included in tuition? Can I choose to send my child with lunch?
We provide nutritious meals and snacks developed by a registered dietician to meet the needs of rapidly growing bodies and minds. If your child has special dietary requirements and you would prefer to bring in their lunch, please make arrangements with the center director.
Does my child need to be potty-trained?
Every child begins toilet learning at a different age. Until your child shows an interest in toilet learning, we'll provide diaper changes on an as-needed basis. When your child shows an interest, we'll discuss how to work together to encourage toilet learning.
Contact this center
If you have questions about tuition and openings tell us about yourself and we will contact you shortly.
Contact me by Contact me by Either Phone or Email Phone Only Email Only
About My Child
Please give us more information about this child
Month Select an option January February March April May June July August September October November December
Year Select an option 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024
Desired Start Date Select an option Immediately January 2023 February 2023 March 2023 April 2023 May 2023 June 2023 July 2023 August 2023 September 2023 October 2023 November 2023 December 2023 More than one year from now
Keep me informed about KinderCare programs.


text:
Donald Parham Gerald Everett Joe Lombardi Football Professional football NFL football Sports Athlete health Athlete injuries
Los Angeles Chargers Kansas City Chiefs
Chargers' Parham going through workouts after scary injury
By JOE REEDY - Jun. 08, 2022 05:27 PM EDT
FILE - Los Angeles Chargers tight end Donald Parham (89) stretches before an NFL football game against the Kansas City Chiefs Thursday, Dec. 16, 2021, in Inglewood, Calif. Parham is participating in the offseason program and is happy to be back on the field, less than three months after he was taken off the field on a stretcher during the first quarter of a Dec. 15 game against the Kansas City Chiefs.(AP Photo/Kyusung Gong, File)
COSTA MESA, Calif. (AP) — No one would have been surprised if Donald Parham tried to ease back into things after suffering a frightening injury late last year.
The Los Angeles Chargers tight end has been participating throughout the offseason program as he prepares for the upcoming season.
Parham resumed offseason training in early March, less than three months after being taken off the field on a stretcher during the first quarter of a Dec. 16 game against the Kansas City Chiefs.
"Yeah. It was perfect timing. I came back, dove right in, and felt great," Parham said. "I'm just taking advantage of every moment that I have back. After everything that happened, it feels good to be back, for sure."
On a fourth-and-goal play, Parham got his hands on a 5-yard pass from Justin Herbert in the back of the end zone, but he dropped the ball when the back of his head slammed into the ground.
After the play, a camera zoomed in on Parham's face, showing his eyes closed and mouth open. A teammate briefly tried to move Parham's left arm, but it was frozen in a bent position.
Trainers and medical personnel removed Parham's facemask from his helmet and placed him on a backboard. The 24-year-old's arms were shaking while he was taken off the field as concerned players from both teams watched.
He was taken to the hospital for tests and was diagnosed with a concussion.
Parham said he remembers everything until medical personnel put him in the ambulance and that he wasn't experiencing any pain. He also noted he has watched the play many times and has come to terms with what happened.
"It was crazy because once it happened and I was in the hospital, I was like, 'Will I ever play again?' That reality set in very quick," he said. "I had to take my time and just think about if this was something that I wanted to do for the rest of my career, just making sure and take the right precautions."
It wasn't until a month after the injury before Parham said he felt around 100%. He was cleared to resume full workouts in early March, usually when he begins his offseason program.
The 6-foot-8, 237-pound Parham has developed into a dependable option for quarterback Justin Herbert. After having 10 catches, including three touchdowns in 2020, Parham doubled his production last season with 20 receptions for 190 yards and three touchdowns.
The Chargers added Gerald Everett during free agency, but Parham's tall frame and prowess in the red zone still make him a vital red zone factor.
Parham's most important focus during the offseason, though, has been improving his lower-body strength so that he can improve in run and pass blocking.
"That was something that I felt that I lacked last year. I want to be an overall tight end, not just a pass-catcher," Parham said.
Offensive coordinator Joe Lombardi has also been pleased with Parham's progress, but is also waiting until hitting starts during training camp and the preseason games to get a full assessment.
"He's made some big plays out there in 7-on-7. Everything that you remember from last year, he looks confident. Everything is real positive," Lombardi said. "We're very excited, the tight end room is exciting between Donald, and Tre' (McKitty), watching him improve last year, then with the addition of Gerald, I think that it's a real strong position for us."


Masaki Saito (斎藤 雅樹, Saitō Masaki, born February 18, 1965 in Kawaguchi, Saitama, Japan) is a Japanese former Nippon Professional Baseball pitcher. He played for the Yomiuri Giants from 1984 to 2001. He won the Eiji Sawamura Award three times, 1989, 1995, and 1996, and he won the Nippon Professional Baseball Most Valuable Player Award in 1990.
This page was last edited on 6 January 2019, at 13:10 (UTC).


The feature length or epic GRANT CONSPIRACY MURDERS, 1880, is set in Mountain Springs, the title for the proposed series. The role of the sheriff will be built up as an anchor for new and ongoing events. The evil partners in the law firm are dead, but the nasty brothers of one of them arrives to take their place in the firm, creating more mischief. Political intrigue, state history, roving gunmen, all create ongoing problems for the sheriff, Matt, Jennifer, and the inventor.


text:
/**
 */
package com.example.example.with.anyelementfeature.impl;

import com.example.example.with.anyelementfeature.AnyelementfeaturePackage;
import com.example.example.with.anyelementfeature.Properties;

import org.eclipse.emf.common.notify.NotificationChain;

import org.eclipse.emf.ecore.EClass;
import org.eclipse.emf.ecore.InternalEObject;

import org.eclipse.emf.ecore.impl.MinimalEObjectImpl;

import org.eclipse.emf.ecore.util.BasicFeatureMap;
import org.eclipse.emf.ecore.util.FeatureMap;
import org.eclipse.emf.ecore.util.InternalEList;

/**
 *
 * An implementation of the model object 'Properties'.
 *
 *

 * The following features are implemented:
 *

 *
{@link com.example.example.with.anyelementfeature.impl.PropertiesImpl#getAny Any}

 *

 *

 *
 * @generated
 */
public class PropertiesImpl extends MinimalEObjectImpl.Container implements Properties {
	/**
	 * The cached value of the '{@link #getAny() Any}' attribute list.
	 *
	 *
	 * @see #getAny()
	 * @generated
	 * @ordered
	 */
	protected FeatureMap any;

	/**
	 *
	 *
	 * @generated
	 */
	protected PropertiesImpl() {
		super();
	}

	/**
	 *
	 *
	 * @generated
	 */
	@Override
	protected EClass eStaticClass() {
		return AnyelementfeaturePackage.Literals.PROPERTIES;
	}

	/**
	 *
	 *
	 * @generated
	 */
	public FeatureMap getAny() {
		if (any == null) {
			any = new BasicFeatureMap(this, AnyelementfeaturePackage.PROPERTIES__ANY);
		}
		return any;
	}

	/**
	 *
	 *
	 * @generated
	 */
	@Override
	public NotificationChain eInverseRemove(InternalEObject otherEnd, int featureID, NotificationChain msgs) {
		switch (featureID) {
			case AnyelementfeaturePackage.PROPERTIES__ANY:
				return ((InternalEList<?>)getAny()).basicRemove(otherEnd, msgs);
		}
		return super.eInverseRemove(otherEnd, featureID, msgs);
	}

	/**
	 *
	 *
	 * @generated
	 */
	@Override
	public Object eGet(int featureID, boolean resolve, boolean coreType) {
		switch (featureID) {
			case AnyelementfeaturePackage.PROPERTIES__ANY:
				if (coreType) return getAny();
				return ((FeatureMap.Internal)getAny()).getWrapper();
		}
		return super.eGet(featureID, resolve, coreType);
	}

	/**
	 *
	 *
	 * @generated
	 */
	@Override
	public void eSet(int featureID, Object newValue) {
		switch (featureID) {
			case AnyelementfeaturePackage.PROPERTIES__ANY:
				((FeatureMap.Internal)getAny()).set(newValue);
				return;
		}
		super.eSet(featureID, newValue);
	}

	/**
	 *
	 *
	 * @generated
	 */
	@Override
	public void eUnset(int featureID) {
		switch (featureID) {
			case AnyelementfeaturePackage.PROPERTIES__ANY:
				getAny().clear();
				return;
		}
		super.eUnset(featureID);
	}

	/**
	 *
	 *
	 * @generated
	 */
	@Override
	public boolean eIsSet(int featureID) {
		switch (featureID) {
			case AnyelementfeaturePackage.PROPERTIES__ANY:
				return any != null && !any.isEmpty();
		}
		return super.eIsSet(featureID);
	}

	/**
	 *
	 *
	 * @generated
	 */
	@Override
	public String toString() {
		if (eIsProxy()) return super.toString();

		StringBuffer result = new StringBuffer(super.toString());
		result.append(" (any: ");
		result.append(any);
		result.append(')');
		return result.toString();
	}

} //PropertiesImpl


hi effuryone! it is me, Meerkat, the birthday girl. My biological brother Panda Bear and i are celebrating our 4th birthday today! efurryone is welcome to join us for a casual celebration.
mom says that for every real (not spam) comment on this post that we receive between now and next Sunday May 22, she will make a donation of $0.50 to the Cleveland Animal Protective League (APL). in addition to having a shelter, they also provide low cost apsy/neuter services, and help communities with TNR (trap – neuter – return). last night, mom and dad and a friend from mommy's work did the T part of TNR and trapped 7 feral cats. dad is taking them to the APL for their hoohaectomies and ladygardenectomies (the N part of TNR).
thanks for visiting! enjoy the festivities! purrs!
Filed by Meerkat on May 16th, 2011 under Birthdays, Meerkat's Posts, TNR. 36 Purrs or Hisses.


This new line is synonymous of design and a handy, perfect combination of our time: unique colours, shapes and models, suitable for every occasion. Refined details as little charming studs and the elegant Samsonite logo plate make this line more attractive. It's the essential accessory for women on the go!


text:
<?php

namespace Cecil\Generator;

use Cecil\Collection\Page\Page;

/**
 * Class TitleReplace.
 */
class TitleReplace extends AbstractGenerator implements GeneratorInterface
{
    /**
     * {@inheritdoc}
     */
    public function generate(): void
    {
        $filteredPages = $this->builder->getPages()->filter(function (Page $page) {
            return null !== $page->getVariable('title');
        });

        /** @var Page $page */
        foreach ($filteredPages as $page) {
            $alteredPage = clone $page;
            $alteredPage->setVariable('title', ucwords($page->getVariable('title')));
            $this->generatedPages->add($alteredPage);
        }
    }
}


text:
EternaCore
Seeking a Different Future
Morning in the Edge
A Wraith in the Machine
Voidwalker: Chapter One, p5
Posted on 24th December 2018 by Caendur — No Comments ↓
"Bloody gnomes," Aziz grumbled to himself. He was holding up the axle of the wagon using a lever, waiting for the gnomish driver to fix the wheel. He was ankle-deep in mud, for though there had been no rain today the stretch of road where the wagon broke had no ditches or other places for the water to go. Instead, all the water from the surrounding hills seemed to have pooled on the road, making it muddy even on a sunny day like this. Re-purposed riverbed, the gnome had called it the first time they got stuck in mud.
Off to the side, Ky was trying to get information about the capital from their fellow travelers. When they had visited the provincial capital they had learned of troubles brewing in the west, on the border to the Empire of the Sun. Soldiers were being recruited, militias armed, and armies mobilized. And here they were, traveling with a merchant named Gethak, headed for the capital of Malqish as though the troubles of their little frontier village would be worth the attention of the prince regent himself.
"There we go," Gethak said, checking to make sure the wheel didn't fall off again. "Once I get my business approved by the prince regent, things like this will no longer be a problem. Because I am going to unify this kingdom in an era of new and improved travel! Only thing better would be magic, but who has the resources to build a network of portals? Do you know how expensive, time-consuming, and draining it is to build a portal? Let alone a dozen? A friend of mine-" The gnome fell silent, gazing at the scowling features of Aziz with a bit of surprise. "Oh right, the trip. All aboard!"
The next few days passed in relative calm, with the exception of Gethak's fondness for ceaselessly talking about things neither Aziz nor Ky understood anything about. Until one day the wagon climbed onto a large hill and there, sprawled out in the valley before them, lay a vast city.
A large river wound its way in from the south, dotted with ferries carrying cargo from the amphibians of the marshes and swamps in the south and their western neighbours among the Trollcrags. At the center of the large valley the river emptied in a lake, Seren. On a small island by the western shore of that lake stood the ruins of Raven's Nest, a castle once home to the kingdom's founder Diarmid Ravenwing. Another river flowed north from the lake, wider and much more trafficked than its southern counterpart as it snaked its way to the coast and the kingdom's only major seaport at Highwater.
The city itself had grown from a small fishing village around the bridgehead, now the estates and private docks of the aristocracy, to a vast metropolis that was home to both the most desolate and wealthy of the land. The city was separated into several districts, although the lack of actual barriers made them hard to see. Except, Aziz noted, for the old city wall; a thick and high wall that now surrounded the nobles' estates.
"These hills always intrigue me," the gnome began, though Aziz paid him no heed. "Most of the area here is pretty flat, and nothing as high as these hills. And if you look at a map, they are suspiciously like a ring around the lake. My theory, therefore, is that Malqish valley is a crater formed by an unusually large shardfall."
"I've never heard of any shardfall causing so big a crater as this." Ky sounded sceptical.
"It must be a rare event, I agree, or we would see lots of these craters everywhere. Nonetheless, I cannot imagine any other phenomena that would cause such a formation."
"Magic?" Aziz didn't really care about the discussion, but the gnome seemed to ignore the obvious answer. Ky nodded in agreement.
"You mean someone would intentionally reshape the land thus?" Gethak almost chuckled at the notion. "Really, that is quite preposterous. In such an event, they would have made the hills much more even in height. And the river would have been taken into account, instead of leaving it alone to eat its way through the hills as it saw fit. Did you know that a few decades ago, there was a small isle over where the river…"
Aziz tuned out the gnome's continued droning and noted that the city was utterly defenseless if an army attacked. It was too big a valley to effectively defend the hills, even if they were to try and hold only one side of the river. So unlike the fortified cities of his homeland, where conquest through war had been the way of things for centuries, and even now settlements would get raided by those descended from guerilla rebels of subjugated tribes.
Unlike the Sollim, though, Malqish had always been a peaceful nation with fertile lands and decent forests. Supplied with ore and stone from the western mountains the kingdom had built its wealth and power through trade. Yet despite its bounty it had not once been forced to enter war, and aside from the garrison at Brighthill it had no need for a standing army.
Surrounded on most sides by lands with no clear power ruling them, it was hardly surprising that in the scant century Malqish had existed no one had bothered to invade. Only the Empire of the Sun to the west had reason for war but they had always seen more benefits to using the kingdom for trade, and the occasional raid by independent slavers coming over the Sandwall mountains.
"What're they doing?" Ky asked suddenly, taking Aziz back to the present. The young farmhand was looking at a caravan of wagons going to and from a tall hill northwest of the city, a hill upon which something was apparently being built.
"I dunno," the magistrate mumbled as he rose slightly from his seat to get a better look. "Building something, that's for sure."
"They are constructing the first out of eight outposts that will keep the capital safe. Once done, they will build a wall between them, thereby sealing this entire valley in. Master Daergo himself has drawn the plans, so I am guessing the wall will not survive the first thunderstorm," Gethak said, shaking his head as if disappointed. "Well, let's go." With that, he set the two oxen in motion again and the wagon slowly began its descent to the great city below.
"You don't think the lord of the gnomes is a capable architect?" Ky asked, looking at the gnome incredulously. "I mean, he's a greatly respected man."
"He is a fool, just like his father before him, and I hear his father before that, as well. But as I do not have any evidence of that one, I shall not say more. Master Daergo is a respectable man, and a capable enough diplomat and ruler, but he would not be able to tell the head of a hammer from that of a pickaxe!" Gethak huffed, starting to get agitated over the man.
"Bloody gnome," Aziz muttered under his breath, while Ky just sat there, pleasantly smiling and listening politely.
"Yes! A foolish and infuriating man, really!" Gethak replied, apparently oblivious that Aziz was referring to him. "Once he tried to build a self-propelling wagon and he ended up destroying the workshop of House Ironlock. Another time he wanted to build this fancy wall to hold off crag trolls, and though the design was fine, he forgot to take into account the natural surroundings. Next rainstorm and the entire thing just collapsed, made it easier than ever for the trolls to get in and eat us." The gnome continued his tirade, talking faster and faster until even Ky seemed unable to keep up.
"Uhh… Sure. This is our stop, thanks for the ride!" Aziz said, hopping off the wagon on a road in the middle of the city.
"You sure you are not going all the way to the Royal Halls? Because I am sure you paid for all the way to the Royal Halls. Let me just find my notebook and I can check-" Gethak said, starting to rummage about in his pack.
"No, no. Do not worry about it, we need to talk to a few people first, make some arrangements. You know, business stuff. Good luck when meeting the prince regent!" Ky said as he smiled pleasantly while climbing off the wagon.
"He's gonna need it," Aziz mumbled, watching the gnome look at them for a moment, then shrug before he set off again. Gethak was waving happily to them as he disappeared into the throng of carriages and wagons crowding the busy street.
"You know, he reminds me of Gem." Ky hoisted his pack onto his shoulders and turned toward the inn. "Well, if Gem hadn't been much older, anwyay."
Aziz let out an amused grunt before disappearing through the doorway.
This entry was posted in Voidwalker, VWChapter1 and tagged Aziz, Gethak, Kyrion by Caendur. Bookmark the permalink.
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I am a Portland Native, a homeowner, and an active participant in this unique and vibrant community. As a loan officer at Cascade Residential Mortgage, I can make the home financing process simple, fast, thorough, and efficient. The end result is a mortgage loan that is tailored to the specific needs of my clients. One phone call to me can save you time and money. It's that simple.
They say in this business the best compliment you can receive is a referral from a satisfied client. Most of my business comes to me in this manner, so you can expect outstanding service, trust, reliability, and total confidentiality. I believe that maintaining long term client relationships is the cornerstone of good business, and I will always work towards that goal.


Next message: [syslinux] any magic bytes in pxelinux.0 that are useable by	/usr/bin/file ?
completely optional, but very easy to activate.
the default boot option is used.
timeout, meaning it does not alter current behaviour.


Who is Logan Montgomery BUrke?
Hailing from small town central Pennsylvania, Logan is now a graduate of Kutztown University with a Bachelor of Fine Arts Degree in Communication Design. He has a strong interest in advertising and the development of concept, and enjoys graphic design as a whole.
During his time at Kutztown University, Logan took interest in primarily advertising and graphic design courses, along with a few extras like interactive design, motion graphics, and typography. His interests in advertising and concept led him to intern at Red Tettemer O'Connell + Partners, where he worked on various assignments for several major clients, including Planet Fitness and MorningStar Farms. Along with a team of other interns, he also helped conceptualize and pitch a rebranding of RTO+P's own gin brand, TUB Gin. These experiences gave him a firm understanding of how to build a campaign from the ground-up, from concept to execution to budgeting.
Logan is currently searching to find an agency in the central Pennsylvania area and work his way up, possibly relocating to other parts of the country if his career journey decides to take him there.


For our latest work with C&A, we chose to explore one of the most fascinating cities in Europe: Budapest.
The five days of photo and video production also gave us the chance to meet six great ladies, and explore the city through their eyes: @carmusha, @anajohnson__, @dazzlingdrew, @murielle, @afashiontaste and the local from Budapest @vivienmadai.
Productions like this make you discover so many facets of a city that you would never get to see as a tourist. With a crew of locals you will not only get in touch with the most frequented places but with so many treasures of the city.
The five days of photo and video production also gave us the chance to meet six great ladies: @carmusha, @anajohnson__, @dazzlingdrew, @murielle, @afashiontaste and the local from Budapest @vivienmadai.
With all of its pulsating corners – the inspiring art scene with galleries and museums, new restaurants and boutique hotels, the jewish quarter, castle district and fisherman bastion, as well as the traditional and historic pastries like Gerbeaud – Budapest is worth a trip!


Home » Sister Spotlight: SOTF Admin Manager's Balancing Act!
Have you had the delight of meeting Tara, Sister #106? She's young, she's sweet and she is devoted to Sisters on the Fly's welfare now and for the future. She is a very special Sister, besides being the daughter of co-founder Maurrie Sussman, Sister #1. Learn a little about her here and maybe learn something you never knew about her.
Tara, you're busy! Do you ever get to any SOTF events?
I try to get to as many SOTF events as I can, but between work and the "No Kids" rule, I can't attend as many as I'd like.
You did attend a Sister Corps event fairly recently. Tell us about it.
The Sister Corps' first ever event in Port Aransas was life changing for me and many Sisters. To be able to physically put my blood, sweat and tears into it, working alongside other Sisters, was profoundly rewarding. I'm so proud to have been part of Sister Corps from its inception and I can't wait to get my hands dirty doing humanitarian work again soon.
You also are a mother of two kids. How do you balance it all?
As the kiddos are getting older (now 7 and 9) and involved in more activities, it's becoming challenging to find the time for everything. I think working from home (Montana) is a major advantage to being able to balance it all. I can find pockets of time to fit work into our busy schedules that someone with a 9-5 job might not be able to find.
You balance a career as a hair stylist as well and are devoted to your regular clients?
Because of the time spent working for Sisters on the Fly from home, I've had to cut down my Salon time quite a bit, but I don't think my clients have felt it much aside from being limited to only seeing me a couple days out of the week. The majority of my clients have been with me 20+ years! I have seen them through major milestones in their lives and they have seen me through mine. Most are like family to me. Plus, it's refreshing to get away from the computer screen sometimes!
Maurrie Sister #1 is your mom. How cool is that? Tell us about your mother-daughter connection.
My mom and I are very close, we talk daily and truly enjoy spending time together. We both relish great food, great wine, Tito's vodka, dogs, the Rocky Mountains, lemon flavored anything, sunshine and books. I am blessed to be able to call her Mom.
As SOTF Website/Administrative Manager what do you like best about it all?
I love the technological side of the job. I'm learning so much about web development and maintenance. Learning new skills is exciting!
Do you have a camper trailer?
I do have a trailer! It's a 1950's 13′ Scotsman. There is some work that needs to be done on it so I haven't been able to use it for a couple of years but it'll be back on the road sooner than later hopefully!
Wonderful article about you Tara!!
Tara, you are a Go- Getter!
Tara you have your priorities in the right places! Great read.
Great article on wonderful you! I talked to you on phone. Looking forward to meeting you in person.


In Mitre's CVE dictionary: CVE-2002-1393.
The KDE team discovered several vulnerabilities in the K Desktop Environment. In some instances KDE fails to properly quote parameters of instructions passed to a command shell for execution. These parameters may incorporate data such as URLs, filenames and e-mail addresses, and this data may be provided remotely to a victim in an e-mail, a webpage or files on a network filesystem or other untrusted source.
By carefully crafting such data an attacker might be able to execute arbitrary commands on a vulnerable system using the victim's account and privileges. The KDE Project is not aware of any existing exploits of these vulnerabilities. The patches also provide better safe guards and check data from untrusted sources more strictly in multiple places.
For the current stable distribution (woody), these problems have been fixed in version 2.2.2-2.2.
The old stable distribution (potato) does not contain KDE packages.
For the unstable distribution (sid), these problems will most probably not be fixed but new packages for KDE 3.1 for sid are expected for this year.


Juwon Jung of Mikro Coffee Roasters in Torquay, Victoria, has won the Australian Specialty Coffee Association (ASCA) Southern Region Cup Tasters Championship, held at Criteria Coffee in Victoria from 13 to 14 October.
"It's exciting [to win] but a little bit scary too," Juwon says.
Little Rogue's MJ Kim and Chanjoo Kim placed second and third respectively.
This was Juwon's second attempt at the Southern Region Cup Tasters Championship title, having placed third in the competition last year.
Competitors in Cup Tasters competitions must pick out the odd coffees from eight sets of three cups. The winner is the taster who picks out the greatest number of correct coffees in the shortest amount of time.
All three Southern Region finalists scored a perfect eight out of eight cups.
Juwon completed his tasting in two minutes and 10 seconds, less than half the time taken by runner-up MJ, who took four minutes and 44 seconds. Chanjoo took six minutes and 30 seconds.
For his cup tasting run, Juwon began tasting from the middle.
To prepare, Juwon says he had to train his other senses as well as taste.
"When I first competed, I thought it was all about the tasting but I've realised I needed to recognise the aroma as well," Juwon says.
Juwon says he has a few other tricks up his sleeve, but won't be revealing them ahead of the 2019 ASCA Australian Coffee Championships, taking place at the Melbourne International Coffee Expo from 7 to 9 February.
Juwon would try to practice at least three times a day, even four times if he had the time. He thanks his wife, Mihan, who he says supported him every step of the way.
The Quality Control and Roaster at Mikro says he'd also like to compete in Roasting Championships and the Brewers Cup down the line.


This delicious blueberry tart recipe is from the awesome blog, http://onecaketwocake.com.
Preheat oven to 350 degrees. Stir together flour, sugar, and salt. Using pastry blender or two knives, cut in butter until crumbly. Press dough together with fingers until it holds together. Press dough into 10-inch tart pan with removable bottom. Prick all over with fork. Bake in bottom third of oven until light golden, about 20 minutes. Let cool on rack.
For the filling: In a saucepan, stir together sugar, cornstarch and salt. Whisk in water, 2 C. blueberries, lemon zest, and cinnamon. Bring to simmer over medium heat. Reduce heat and simmer gently, stirring often, until glossy and thickened (about 10 minutes). Remove from heat and stir in lemon juice and butter. Let cool slightly.
This recipe and photo are published with permission from One Cake, Two Cake.


text:
Three Racecourses To Visit In England
A trip to the races is a bucket list item when visiting the United Kingdom. There are race meetups and, down the country, almost every weekend features jumps racing during the autumn and winter months, while during spring and summer flat racing is on the agenda.
It's certainly worth a day out to take in the festivities with a beverage of two and we'll now tell you the best places to visit up and down England on the racing calendar.
10 days to go! 😍#GrandNational #TheWorldisWatching #SeeYouThere pic.twitter.com/GMqAGRO2fj
— Aintree Racecourse (@AintreeRaces) March 25, 2019
The venue is situated five miles outside of Liverpool and hosts the most prestigious of races – the Grand National. It boasts a capacity of 70,000 and provides a unique experience if you're fortunate enough to get a ticket for the world's most famous horse race, which takes place in early April.
There are few sporting events like it in the world, providing a unique insight into a British and Irish tradition.
The roar of the crowd at the start of the race raises the hairs on the back of the neck. If you like the elite standard of competition, it's certainly worth the entrance fee, which is more than reasonable at around £30 for a place in the enclosure for Grand National day.
If you're in the vicinity of Liverpool, Haydock Park is also within a short distance of the city. It does not have the grandeur of Aintree, although it does host its fair share of premier events.
It's used widely across the year for both codes of the sport, but primarily has a focus in jumps season. The horses competing at Haydock are not as well known as their counterparts elsewhere for a regular meet. As a result, it's worth monitoring the daily racing tips before heading to the racecourse and delving into a punt.
The Betfair Chase is the signature race of the year, occurring in October. It features some of the elite horses on the National Hunt and has been won for the past two years by Bristol De Mai.
🚨 ONE HOUR TO GO KLAXON 🚨
The last in the @MagnersUK Cheltenham Gold Cup, who will be jumping the final fence in front? pic.twitter.com/tiiAhfs1gn
— CheltenhamRacecourse (@CheltenhamRaces) March 15, 2019
Cheltenham hosts the week-long Cheltenham Festival in March. For lovers of horse racing, it's paradise. It's non-stop talk of racing for four-straight days, featuring the elite horses from jumps racing.
Over 250,000 people attend the event over the course of the week, whether you're in the concourses or the hospitality areas. Like the Grand National, it's an experience that shouldn't be passed up.
The racecourse and surrounding areas themselves are an attractive place to visit on a normal occasion. Based in the Cotswolds, Cheltenham is a perfect getaway in the English countryside – outside of the hustle and bustle of major cities.
The Best Autumn Activities in London For Kids
Editor - Aug 28, 2018


It's Fan Appreciation Night at Our House as the Blues head into Hurricanes territory. Join us for the final Investec Super Rugby round robin home match of 2018.
The Stadium car park is open for this event at a cost of $30 (please note there is a fee for paying by credit card or eftpos of .60c). Get in early as the car park will sell-out at this match.
The best way to get to and from the stadium is via public transport, please plan your journey beforehand.
Plus if you use the app on any Westpac Stadium game day, you are in the draw to win great prizes. To celebrate the launch of the new app, at this week's Hurricanes v Blues game we are thrilled to be giving away to one lucky user, a newly released Nova e3 Huawei smartphone - thanks to our friends at Huawei.


4/5/2010 – Cementing its status as the epicentre of the chessboxing universe, London's historic Boston Dome hosted three action-packed fights. Followed by a sell-out 500-strong crowd. It was the first of five UK chessboxing events planned for London in 2010, ably promoted by Tim Woolgar of the GBCBO, in partnership with the WCBO. Pictures by James Bartosik, report by Rajko Vujatovic.
Chessboxing combines the ultimate mental and physical sports, with alternating rounds of chess and boxing. The position on the chessboard is preserved between chess rounds, so checkmate or knockout wins – whichever comes first! Each player has 12 minutes on his clock for all moves, so there is a maximum of 11 rounds: six four-minute chess and five three-minute boxing rounds.
The night's line-up consisted of a heavyweight contest between Sergio "The Phoenix" Leveque and Tim Woolgar; a middleweight bout between Spain's Daniel Lizarraga and Germany's Sebastian Bauersfeld; and a rookie fight between Englishmen Johnny Higginson and Rob Gillies.
More fantastic pictures on this and previous chessboxing events can be found on the website of photographer James Bartosik.
The headline international bout was between English heavyweight champion, Tim Woolgar, and the colossal Italian, Sergio "The Phoenix" Leveque.
Chess master Leveque (pictured above with coach Gianni Burci) prepares for his chessboxing debut, marking the final step in his recovery from a horrendous motorbike accident in 2005, when doctors doubted he would ever walk again. Leveque has a clutch of boxing fights under his belt and has played in Italy's premier chess league; with a chess Elo rating of 2059, he was the favourite to win by checkmate!
Englishman Woolgar, who was also promoting the event, stepped in as a replacement a month before the fight, when Leveque's scheduled opponent had to withdraw for personal reasons. Woolgar's Elo has doubled from 800 to 1600 in the past two years, and is still on an upwards trajectory.
Since establishing chessboxing in London two years ago, Tim Woolgar has arguably done more for the profile of UK chess than anyone since Nigel Short challenged Garry Kasparov in London for the 1993 world title! This latest event achieved global media coverage on countless national TV networks, and chess organisers should be encouraged to creatively leverage off this success to raise the profile of the game in the mainstream media.
The game that followed was an excellent example of how the quality of the chess moves mirrored events in the preceding boxing round. Leveque drew the white pieces, which in chess bestows an advantage similar to the serve in tennis. He played the dangerous Wing Gambit to try to smash Woolgar's French Defence. Woolgar, unfamiliar with the gambit, wisely declined the pawn. Both men were satisfied at the end of the opening chess round; Leveque had a positional advantage, whilst the out-rated Woolgar was ahead on the clock and had successfully defended against being quickly wiped out with the black pieces.
The chess set and furniture were then removed from the middle of the ring and the boxing commenced, when the Italian was slow to warm up and the more agile Woolgar had the upper hand. Then back to the chess; Woolgar solidified his position, frustrated his opponent and even ended the round on move 17 with the slightly more pleasant position, after Leveque failed to exploit Black's dark square queenside weaknesses. But then Leveque got into his flow, and before the bell he caught Woolgar with a nasty right hook. The Englishman stayed on his feet but was still disorientated at the end of the round. His first move back at the board was a grave error which Leveque punished with bloody carnage uglier than anything ever seen in a boxing ring. The Black king denuded of its defences was checkmated on move 28. Game over!
The following ChessBoxing game is an excellent example of how the quality of chess moves mirrors events in the preceding boxing round. Despite being heavily outrated by the colossal Italian master, Sergio "The Phoenix" Leveque, Englishman Tim Woolgar improved his position after having a better initial boxing round, but the reverse happened after he suffered a setback in the second boxing round. Each player has 12 minutes for all moves. There is a maximum of 11 chessboxing rounds: six four-minute chess rounds alternating with five three-minute boxing rounds. 1.e4 e6 2.Nf3 d5 3.e5 c5 4.b4!? The Wing Gambit against the French Defence shows White's aggressive intentions; he is willing to sacrifice a wing pawn to remove one of Black's central pawns. 4...Nc6. Woolgar smells a rat; he is unfamiliar with the gambit and declines the pawn. A great pychological choice which makes the Italian use up a lot of time deciding how best to proceed. Accepting the pawn with 4...cxb4 gives a murky position after 5.a3 Nc6 6.axb4 Bxb4 7.c3 Be7 8.d4 White's pawn wedge on e5 gives compensation for the pawn, and play may continue 8...f6!? 9.Bd3 fxe5 10.dxe5 Qc7 11.Qe2 Nh6! unclear.; 4...c4!? is rare but I see nothing too wrong with this way of declining the pawn.
9...h6! A necessary and profound preparation for castling. The routine 9...0-0? is fascinating as it would be met with the standard 'Greek Gift' sacrifice 10.Bxh7+!! Kxh7 11.Ng5+ Kg8 (11...Kg6 12.h4! gives a devestating attack against Black's naked king, and threatens to win the queen with 13.h5 Kh6 14.Nxf7+ Kh7 15.Nxd8. After, for example, 12...Qc8 one of many ways to continue the attack is 13.Qg4 (13.h5+ Kh6 14.Qd3 Nf5 15.Nxe6+ Kh7 16.Qxf5+ Kg8 17.h6 fxe6 18.Qg6 also wins) 13...Nf5 14.h5+ Kh6 15.Nxf7+ Kh7 16.Qg6+ Kg8 17.Ng5 Rd8 18.Qf7+ Kh8 19.h6 Nxh6 20.Rxh6+ gxh6 21.Qh7#) 12.Qh5 with a mating attack. 12...Re8 13.Qh7+ Kf8 14.Qh8+ Ng8 15.Nh7+ Ke7 16.Bg5+ Nf6 (16...f6 17.Qxg7#) 17.Bxf6+ gxf6 18.Qxf6#; 9...Na5 is objectively best, but such ideas come only with grandmasterly experience of the French Defence. Woolgar has been taught not to move a piece twice in the opening, and that a 'knight on the rim is dim'.
Joe now imparts his expertise to the slightly smaller-framed contenders at the London ChessBoxing club. "I saw that checkmate a mile off", he said. "Tim should have forced the exchange of light-squared bishops, and then he'd be laughing, since White has no attack." It's always so much easier being a kibitzer!
As always, the interval entertainment at a chessboxing event was itself worth the ticket price! Finnish Hula Hoop artiste Tiina Tuomisto performed mind-boggling contortions, whilst gyrating the hoops about her person in a paradoxical arrangement of orthogonal planes. Hula chess queen Jennifer Shahade should take note!
reputedly related to surrealist artist Salvador Dali.
Daniel Lizarraga (right) against Berliner Sebastian Bauersfeld.
Bauersfeld was born to be a chessboxer – his grandfather was a chess master whilst his father was a former GDR boxing champion. Furthermore, he has a lucky name – Bauersfeld means 'pawn square' in German, literally 'farmer field'. Lizarraga was looking for his second chessboxing victory. At his debut in December 2009, he narrowly defeated Bauersfeld's stable-mate, Sascha Wandkowsky, by a points decision which went to the wire.
In the most tense match of the night, Lizarraga played the Fantasy Variation against Bauersfeld's Caro-Kann. The chess advantage swayed back and forth – as soon as one fighter obtained the advantage, the other would doggedly defend until fortunes swayed. The tension ratcheted up every round and the crowd avidly followed the chess on the big screen.
Interspersed with the chess were five enthralling boxing rounds, where attack and defence ebbed and flowed just as in the chess game. Without a knockout, and with the chess a draw, the boxing points decision was awarded to Lizarraga.
proudly returned to Pamplona with victory and a black eye!
Each player has 12 minutes for all moves. There is a maximum of 11 chessboxing rounds: six four-minute chess rounds alternating with five three-minute boxing rounds. 1.e4 c6 2.d4 d5 3.f3. The Fantasy Variation! Lizarraga loves gambit play, but Bauersfeld is a solid guy who prefers to avoid complications. 3...dxe4 4.fxe4 Nd7 5.Bc4 Nb6 6.Bb3 Nf6 7.Nc3 Bg4 8.Nf3 Bh5 9.0-0 Bg6 10.Qe1 e6 11.Bg5. 11.e5! is a thematic idea, when White is clearly better after 11...Nfd5 12.Ne4+/–. 11...Be7. End of round 1 (chess) 12.Ne5??
The welterweight rookie encounter was between two chessboxing enthusiasts.
TV producer Rob Gillies (right) was making a programme on his chessboxing adventure, as well as raising money for 'The Railway Children', a charity which helps runaway children. Johnny Higginson (left) is political editor of London's Metro newspaper, and last year interviewed Prime Minister Gordon Brown in his residence, 10 Downing Street, prior to the G20 conference in London. Higginson has also written a satirical play, 'Stiffed!', on the UK's political Expenses Scandal, which will run in London's Tabard Theatre from 14 April 2010, in the run-up to the general election.
Both Higginson (pictured above) and Gillies were on the lower rungs of the competitive chess ladder. This was fantastic for the general public, who could easily understand what was going on by simply counting the pieces.
As usual the fight started with the chess; Gillies was White and played an unorthodox opening attack with his queen. If 2.Qh5 were to lead to a quick checkmate, it would go down in history as The Boston Dome Attack! Higginson, however, thwarted those ambitions by chasing the queen away. After further adventures over all corners of the board, the excitement peaked in round three when Higginson carelessly lost his queen but recaptured it a few moves later with a cunning trick – he had disguised his queen's bishop as a big pawn! From covering Westminster's political machinations, he has clearly learnt how to get himself out of a scrape!
taller Higginson, knocking him down in round four.
In round five, Higginson gained a decisive advantage on the board with a knight fork and was destined to queen a passed pawn. Gillies knew he needed a KO in round six and came close to doing so when an exhausted Higginson ran out of steam. But the parliamentary journalist survived and mopped up chess victory in round seven. Higginson will undoubtedly have something interesting to talk about the next time he meets the Prime Minister! Click here to replay the game.
This game is a real curiosity in a duel that showed more twists than an Agatha Christie novel! Johnny Higginson is the talented young political correspondent of London's Metro newspaper, whilst Rob Gillies is a successful TV producer. Both gentlemen are keen casual players new to competitive chess, and had taken up the chessboxing challenge to make all their moves in 8 minutes. This was accelerated chessboxing with a maximum of 7 rounds: 4 chess rounds and 3 boxing rounds. 1.e4 e6 2.Qh5 An eccentric opening from TV producer Gillies, who was making a light-hearted documentary on his chessboxing initiation. 2...g6 3.Qf3 d5 4.d3 Nf6 5.Bf4 Bd6?
6.Bxd6? 6.e5! is a nice fork. 6...Qxd6?? 7.d4?? [7.Qxf6!] 7...0-0?? For several moves, both players remain blissfully unaware that White can win a piece with Qxf6, whilst Black has ...Nxe4 at his disposal. 8.Bb5 c6 9.Ba4 b5 10.Bb3 Na6 11.Ne2 Nb4 12.0-0 Ba6 13.Nf4 dxe4! At last... Black notices the danger before White! 14.Qe3 Ng4 15.Qxe4 End of round 1 (chess). 15...Rae8 16.c3 Nd5 17.Nd2?? Nxf4! The wily political correspondent wins a knight. 18.h3 Nf6 [18...Ne2+!! is an advanced combination for this level, but could've ended proceedings after 19.Qxe2 Qh2#] 19.Qf3 b4 20.Nc4 bxc3?? 21.Nxd6! In the chaos, Black blunders his queen. 21...Ne2+ 22.Qxe2?? White offers to return the favour. 22...Bxe2! The Black bishop looked like a big pawn on the wings, but now comes into its own. 23.Nxe8 Bxf1 24.bxc3?? [24.Nxf6+! keeps White well ahead since the capture comes with check.] 24...Nxe8 25.Kxf1 Nf6 26.Ba4 Rc8 End of round 3 (chess). After an extraordinary melee, the chessboxing gladiators have reached complete material balance. 27.Rb1 Ne4 28.c4??
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Klik butang Finish setelah melengkapkan Certificate Import Wizard. Klik dua kali pada certificate Enterprise Trust. Klik pada ikon aplikasi Microsoft Outlook. You can respond to any message in the conversation by using Reply, Reply all, or Forward at the top of the message. Di bahagian Archive items older than, pilih tarikh pada sebelum berlakunya arkib.
Details Category: Showcase Created on 23 September 2013 Last Updated on 18 October 2013 Written by Rafidah Hanem Bt Md Dalil Hits: 8147. Klik butang Yes untuk instalasi Certificate. Klik Install Now untuk memulakan proses pemasangan. This article is for Outlook Web App, which is used by organizations that manage email servers running Exchange Server 2013 or 2010. Satu paparan sekuriti akan dipaparkan untuk pengguna memasukkan maklumat berkenaan User Name contoh: 1govuchidayah. Klik Browse untuk memilih fail certificate dan kemudian klik butang Next.
If your browser doesn't support scripts, you can download Windows Int. When you open Mail, the message list is in the center pane, flanked on the left by the Folder list, and on the right by the reading pane. Open your world, get organized, and have some fun. Click Views to see your entire history neatly organized. See every photo and doc you've ever sent or received. To create a folder that's not a subfolder, right-click or tap and hold your name above your Inbox folder and then choose Create new folder.
This happens automatically when you start typing, and can be configured using your web browser's settings. Use it if you're on a slow connection or using a computer with unusually strict browser security settings. Webmail 1govuc my keyword after analyzing the system lists the list of keywords related and the list of websites with. Mail Search by keyword, contact, date, or any combination. Seterusnya pilih E-mail Account dan masukkan maklumat yang diperlukan seperti: i.
Outlook webmail 1govuc gov my keyword after analyzing the system lists the list of keywords related and the list of websites with related. You can choose to manually add your signature or to automatically add it to all messages or to individual messages. See to learn more about available options. Click here to check your email. Nota: Jika Alamat E-mel dikesan secara automatik kepada pengguna agency. Saiz akaun Outlook yang lebih besar, akan melambatkan prestasi aplikasi Outlook.
If the latter, it could also be an expected behavior. There also are other tools available with the message list to let you take care of some tasks. Add an existing signature If you haven't created a signature, see. See the topics below to learn more about Junk mail, and how to manage the settings. For information about how to allow scripts, consult the Help for your browser. Masukkan kata laluan pada paparan Certificate Import Wizard bagi Password.
Klik Start dan pilih Control Panel. Satu paparan sekuriti akan dipaparkan untuk pengguna memasukkan maklumat berkenaan User Name contoh: 1govuchidayah. Klik pada butang Install Certificates. Junk Email folder Mail identified as possible junk email is automatically moved to the Junk Email folder. For example, type the name of a person you want to find messages from, or enter text that you want to search for to find a particular message.
Arkib direka untuk menyimpan semua data dalam satu tempoh masa yang panjang. To clear your search, choose the icon at the right of the search box. When you delete a message, it's sent to the Deleted Items folder. Pilih butang radio Archive this folder and all subfolders. When you open Mail, you get a quick view of your standard and any custom folders, a list of received messages, and a reading pane that lets you quickly review the content of any message you choose.


In today's news here (http://news.bbc.co.uk/1/hi/england/hampshire/4282740.stm) is the story of a 46yo man who has been jailed for 8 years, for causing the death of a 2yo boy by dangerous driving. He was not drunk at the time, but was an unsupervised learner driver who reversed over a wall, onto a beach, crushing the boy and seriously injuring his father.
Compare that with this (http://www.lse.co.uk/ShowStory.asp?story=AY1917733S&news_headline=road_rage_driver) the 22yo "road rage" driver jailed for 4.5 years. He was three times over the limit, when he forced a car off the road, killing two teenagers. Through a technicality, he was only charged with careless driving, because the prosecution could not prove that the other car left the road because he rammed it, or because the other driver "lost control"!!!!
Uninjured himself, he dragged one of the injured passengers out of the other car and started punching him. When questioned at the scene by police, he showed no remorse and said - "look what they've done to my f***ing car".
I am sure the legal experts will say that the length of sentence is dictated by the actual charge, rather than the circumstances, but IMHO I can't see that the first case was nearly twice as "bad" as the second.
I read the other day that they are now appointing magistrates in their early 20s !


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Foster City, Calif., Jan 15 - Arena Solutions, Inc., the leading provider of online product lifecycle management (PLM) solutions, will demonstrate a new integration of Arena PLM and SolidWorks' PDMWorks software at SolidWorks World 2004 from January 17-21 in Boston, Massachusetts. The integration provides manufacturers using PDMWorks software with new capabilities for sharing and controlling changes to CAD files, including the ability to tie CAD drawings into the complete product record and extend engineering change order (ECO) control to CAD files. This new solution also lets designers share CAD files in a controlled and secure PLM environment with globally dispersed suppliers and partners. In combination, these capabilities improve engineering and manufacturing efficiencies that enable faster design cycles with improved levels of change control.
With the Arena PLM-PDMWorks integration solution, engineers can focus on their core responsibilities of designing parts and assemblies rather than worrying about the tedium of producing and distributing files. As soon as a CAD engineer releases a file in PDMWorks, it automatically becomes available in Arena PLM in an easy, readable distribution format, such as eDrawings™ or PDF. It is then instantly accessible as part of a complete product record—including other non-modeled product data—to the entire design and manufacturing team for review, markup, comment and approval. Metadata such as titles, revisions and authors are all transferred with the files to Arena PLM.
Arena PLM-PDMWorks also extends Arena's powerful change control functionality to CAD drawings in the context of the complete product record. Engineers are no longer faced with the ambiguity of determining whether drawings that have been "released" in the PDMWorks vault are associated with an effective version of an item in production. All changes to actual product definition data are completely ECO-controlled within Arena PLM, providing a complete and current view of production data. By using Arena PLM's electronic change management functionality, engineers can control the release of all new data to manufacturing and maintain a complete change history. This is a key requirement in total quality management and to obtain ISO or FDA compliance.
The Arena PLM-PDMWorks integration solution is currently available to Arena PLM users as an optional module. Customers can access Arena PLM from any computer with a web browser; there is no traditional software to install, maintain or upgrade. New Arena customers can be up and running within days. For pricing information, please call Arena Solutions' sales department at +1.866.937.1438.
SolidWorks Corporation, a Dassault Systèmes S.A. (Nasdaq: DASTY, Euronext Paris: #13065, DSY.PA) company, develops and markets software for mechanical design, analysis, and product data management. Founded in 1993, SolidWorks' mission is to unleash the power of 3D for everyone in product development and foster a collaborative user community. In seven years of delivering product, SolidWorks has shipped more than 285,000 total seats of software worldwide. SolidWorks has offices around the globe and sells, distributes, and supports its products through a worldwide reseller network. For the latest news, information, call 1-800-693-9000 (outside of North America, call +1-978-371-5000).
Pedestal Networks is the first company to make universal broadband a profitable proposition. Pedestal's Universal Broadband Server (UBS) allows carriers to overcome technical and economic barriers to deliver standards-based ADSL services profitably to anyone, anywhere. Headquartered in Fremont, California, Pedestal has secured $14 million in funding from Benchmark Capital, Doll Capital Management, and Skymoon Ventures.


text:
The role of nm23 in transforming growth factor β1-mediated adherence and growth arrest
Stephen Hsu, F. Huang, L. Wang, S. Banerjee, S. Winawer, E. Friedman
nm23 has properties of a metastasis suppressor gene and also has been implicated in the control of response to transforming growth factor β1 (TGFβ1) by studies in melanoma cells. In this report, we have examined the role of nm23 in two HT29 colon carcinoma sublines at different stages in tumor progression with different responses to TGFβ1: the HD3 subline, which shows TGFβ1-induced growth arrest and differentiation; and the more invasive and tumorigenic U9 subline, which induces tumors 7-fold as large as those induced by HD3 cells with one-half the latency. Analysis by semiquantitative reverse transcription-polymerase chain reaction showed that antisense phosphorothiolated oligonucleotides to the nm23 initiation site (nm23 AS oligos) decreased nm23 mRNA levels 2-8-fold in HD3 and U9 cells when normalized to β-actin mRNA levels. However, a role for nm23 in TGFβ1- mediated responses could only be found in HD3 cells. nm23 AS oligos inhibited the differentiation property of cell adherence over 90% in HD3 cells, and this loss of adherence could be partially blocked by concurrent treatment with TGFβ1. In contrast, U9 cell adherence was not detectably altered by nm23 AS oligos, whether added in the presence or absence of TGFβ1. The TGFβ1-induced inhibition of HD3 cell proliferation was blocked by nm23 AS oligos, whereas the TGFβ1-induced proliferation of U9 cells was unaffected by nm23 AS oligos. TGFβ1 increases nm23 mRNA and protein levels in HD3 cells, which may explain the opposing effects of nm23 AS oligos and TGFβ1 in these cells. No mutation in the coding sequence of nm23 was detected in U9 cells to explain the lack of effects of nm23 AS oligos. nm23 mRNA and protein levels were similar in the two lines. We have recently shown that TGFβ1 induces two distinct signal transduction pathways in epithelial cells (Z. Yan et al., J. Biol. Chem., 269: 13231-13237, 1994), one leading to increased cell adherence and growth arrest in HD3 cells, with the other leading to increased invasion and tumorigenicity in U9 cells. The data in the current study indicate that nm23 functions only in the TGFβ1 signaling pathway leading to growth arrest and differentiation. After colon carcinoma cells have progressed to a more aggressive phenotype and use TGFβ1 to stimulate growth and invasion (S. Hsu, et al., Cell Growth and Diff., 5: 267-275, 1994), the second TGFβ1 signaling pathway is used which does not include nm23. Loss of nm23 function occurs in melanoma cells because of a decrease in expression level, whereas by this model in more aggressive colon carcinoma cells, loss of nm23 function occurs by use of an alternative TGFβ1 signaling pathway.
Cell Growth and Differentiation
N-glycolylneuraminyllactosylceramide
Hsu, S., Huang, F., Wang, L., Banerjee, S., Winawer, S., & Friedman, E. (1994). The role of nm23 in transforming growth factor β1-mediated adherence and growth arrest. Cell Growth and Differentiation, 5(9), 909-917.
The role of nm23 in transforming growth factor β1-mediated adherence and growth arrest. / Hsu, Stephen; Huang, F.; Wang, L.; Banerjee, S.; Winawer, S.; Friedman, E.
In: Cell Growth and Differentiation, Vol. 5, No. 9, 01.01.1994, p. 909-917.
Hsu, S, Huang, F, Wang, L, Banerjee, S, Winawer, S & Friedman, E 1994, 'The role of nm23 in transforming growth factor β1-mediated adherence and growth arrest', Cell Growth and Differentiation, vol. 5, no. 9, pp. 909-917.
Hsu S, Huang F, Wang L, Banerjee S, Winawer S, Friedman E. The role of nm23 in transforming growth factor β1-mediated adherence and growth arrest. Cell Growth and Differentiation. 1994 Jan 1;5(9):909-917.
Hsu, Stephen ; Huang, F. ; Wang, L. ; Banerjee, S. ; Winawer, S. ; Friedman, E. / The role of nm23 in transforming growth factor β1-mediated adherence and growth arrest. In: Cell Growth and Differentiation. 1994 ; Vol. 5, No. 9. pp. 909-917.
@article{d4137f460c564a39b21e0078692f455f,
title = "The role of nm23 in transforming growth factor β1-mediated adherence and growth arrest",
abstract = "nm23 has properties of a metastasis suppressor gene and also has been implicated in the control of response to transforming growth factor β1 (TGFβ1) by studies in melanoma cells. In this report, we have examined the role of nm23 in two HT29 colon carcinoma sublines at different stages in tumor progression with different responses to TGFβ1: the HD3 subline, which shows TGFβ1-induced growth arrest and differentiation; and the more invasive and tumorigenic U9 subline, which induces tumors 7-fold as large as those induced by HD3 cells with one-half the latency. Analysis by semiquantitative reverse transcription-polymerase chain reaction showed that antisense phosphorothiolated oligonucleotides to the nm23 initiation site (nm23 AS oligos) decreased nm23 mRNA levels 2-8-fold in HD3 and U9 cells when normalized to β-actin mRNA levels. However, a role for nm23 in TGFβ1- mediated responses could only be found in HD3 cells. nm23 AS oligos inhibited the differentiation property of cell adherence over 90{\%} in HD3 cells, and this loss of adherence could be partially blocked by concurrent treatment with TGFβ1. In contrast, U9 cell adherence was not detectably altered by nm23 AS oligos, whether added in the presence or absence of TGFβ1. The TGFβ1-induced inhibition of HD3 cell proliferation was blocked by nm23 AS oligos, whereas the TGFβ1-induced proliferation of U9 cells was unaffected by nm23 AS oligos. TGFβ1 increases nm23 mRNA and protein levels in HD3 cells, which may explain the opposing effects of nm23 AS oligos and TGFβ1 in these cells. No mutation in the coding sequence of nm23 was detected in U9 cells to explain the lack of effects of nm23 AS oligos. nm23 mRNA and protein levels were similar in the two lines. We have recently shown that TGFβ1 induces two distinct signal transduction pathways in epithelial cells (Z. Yan et al., J. Biol. Chem., 269: 13231-13237, 1994), one leading to increased cell adherence and growth arrest in HD3 cells, with the other leading to increased invasion and tumorigenicity in U9 cells. The data in the current study indicate that nm23 functions only in the TGFβ1 signaling pathway leading to growth arrest and differentiation. After colon carcinoma cells have progressed to a more aggressive phenotype and use TGFβ1 to stimulate growth and invasion (S. Hsu, et al., Cell Growth and Diff., 5: 267-275, 1994), the second TGFβ1 signaling pathway is used which does not include nm23. Loss of nm23 function occurs in melanoma cells because of a decrease in expression level, whereas by this model in more aggressive colon carcinoma cells, loss of nm23 function occurs by use of an alternative TGFβ1 signaling pathway.",
author = "Stephen Hsu and F. Huang and L. Wang and S. Banerjee and S. Winawer and E. Friedman",
journal = "Molecular Cancer Research",
T1 - The role of nm23 in transforming growth factor β1-mediated adherence and growth arrest
AU - Hsu, Stephen
AU - Huang, F.
AU - Wang, L.
AU - Banerjee, S.
AU - Winawer, S.
AU - Friedman, E.
N2 - nm23 has properties of a metastasis suppressor gene and also has been implicated in the control of response to transforming growth factor β1 (TGFβ1) by studies in melanoma cells. In this report, we have examined the role of nm23 in two HT29 colon carcinoma sublines at different stages in tumor progression with different responses to TGFβ1: the HD3 subline, which shows TGFβ1-induced growth arrest and differentiation; and the more invasive and tumorigenic U9 subline, which induces tumors 7-fold as large as those induced by HD3 cells with one-half the latency. Analysis by semiquantitative reverse transcription-polymerase chain reaction showed that antisense phosphorothiolated oligonucleotides to the nm23 initiation site (nm23 AS oligos) decreased nm23 mRNA levels 2-8-fold in HD3 and U9 cells when normalized to β-actin mRNA levels. However, a role for nm23 in TGFβ1- mediated responses could only be found in HD3 cells. nm23 AS oligos inhibited the differentiation property of cell adherence over 90% in HD3 cells, and this loss of adherence could be partially blocked by concurrent treatment with TGFβ1. In contrast, U9 cell adherence was not detectably altered by nm23 AS oligos, whether added in the presence or absence of TGFβ1. The TGFβ1-induced inhibition of HD3 cell proliferation was blocked by nm23 AS oligos, whereas the TGFβ1-induced proliferation of U9 cells was unaffected by nm23 AS oligos. TGFβ1 increases nm23 mRNA and protein levels in HD3 cells, which may explain the opposing effects of nm23 AS oligos and TGFβ1 in these cells. No mutation in the coding sequence of nm23 was detected in U9 cells to explain the lack of effects of nm23 AS oligos. nm23 mRNA and protein levels were similar in the two lines. We have recently shown that TGFβ1 induces two distinct signal transduction pathways in epithelial cells (Z. Yan et al., J. Biol. Chem., 269: 13231-13237, 1994), one leading to increased cell adherence and growth arrest in HD3 cells, with the other leading to increased invasion and tumorigenicity in U9 cells. The data in the current study indicate that nm23 functions only in the TGFβ1 signaling pathway leading to growth arrest and differentiation. After colon carcinoma cells have progressed to a more aggressive phenotype and use TGFβ1 to stimulate growth and invasion (S. Hsu, et al., Cell Growth and Diff., 5: 267-275, 1994), the second TGFβ1 signaling pathway is used which does not include nm23. Loss of nm23 function occurs in melanoma cells because of a decrease in expression level, whereas by this model in more aggressive colon carcinoma cells, loss of nm23 function occurs by use of an alternative TGFβ1 signaling pathway.
AB - nm23 has properties of a metastasis suppressor gene and also has been implicated in the control of response to transforming growth factor β1 (TGFβ1) by studies in melanoma cells. In this report, we have examined the role of nm23 in two HT29 colon carcinoma sublines at different stages in tumor progression with different responses to TGFβ1: the HD3 subline, which shows TGFβ1-induced growth arrest and differentiation; and the more invasive and tumorigenic U9 subline, which induces tumors 7-fold as large as those induced by HD3 cells with one-half the latency. Analysis by semiquantitative reverse transcription-polymerase chain reaction showed that antisense phosphorothiolated oligonucleotides to the nm23 initiation site (nm23 AS oligos) decreased nm23 mRNA levels 2-8-fold in HD3 and U9 cells when normalized to β-actin mRNA levels. However, a role for nm23 in TGFβ1- mediated responses could only be found in HD3 cells. nm23 AS oligos inhibited the differentiation property of cell adherence over 90% in HD3 cells, and this loss of adherence could be partially blocked by concurrent treatment with TGFβ1. In contrast, U9 cell adherence was not detectably altered by nm23 AS oligos, whether added in the presence or absence of TGFβ1. The TGFβ1-induced inhibition of HD3 cell proliferation was blocked by nm23 AS oligos, whereas the TGFβ1-induced proliferation of U9 cells was unaffected by nm23 AS oligos. TGFβ1 increases nm23 mRNA and protein levels in HD3 cells, which may explain the opposing effects of nm23 AS oligos and TGFβ1 in these cells. No mutation in the coding sequence of nm23 was detected in U9 cells to explain the lack of effects of nm23 AS oligos. nm23 mRNA and protein levels were similar in the two lines. We have recently shown that TGFβ1 induces two distinct signal transduction pathways in epithelial cells (Z. Yan et al., J. Biol. Chem., 269: 13231-13237, 1994), one leading to increased cell adherence and growth arrest in HD3 cells, with the other leading to increased invasion and tumorigenicity in U9 cells. The data in the current study indicate that nm23 functions only in the TGFβ1 signaling pathway leading to growth arrest and differentiation. After colon carcinoma cells have progressed to a more aggressive phenotype and use TGFβ1 to stimulate growth and invasion (S. Hsu, et al., Cell Growth and Diff., 5: 267-275, 1994), the second TGFβ1 signaling pathway is used which does not include nm23. Loss of nm23 function occurs in melanoma cells because of a decrease in expression level, whereas by this model in more aggressive colon carcinoma cells, loss of nm23 function occurs by use of an alternative TGFβ1 signaling pathway.
JO - Molecular Cancer Research
JF - Molecular Cancer Research


This is one of the best value reds from Spain. The vineyards for Monte Oton are high on the windswept slopes of the extinct volcano, Moncayo. The sun-drenched, arid location is ideal for harvesting fully ripened Garnacha grapes from vines that are up to 25 years old. The wine bursts with red cherry/strawberry fruit, and has a softly plump texture, sharpened with just enough acidity to uplift the long savoury/stoney finish. Very satisfying with pork tenderloin, or a spicy chorizo pilaf.


Analytics helps the bank minimize losses and handle new growth opportunities for its loan portfolio.
Modeling portfolio credit risk is a fundamental function in banking today. Loan products, such as lines of credit, mortgages and credit cards, entail a high degree of risk for banks, and on a large scale, especially in turbulent economic periods – defaults produce difficult situations and huge implications for both the lender and the borrower.
Banks regularly employ credit-risk management processes to monitor and assess credit portfolios, to make certain estimates, and to understand their risk position and value of assets at any given time. In today's complex and ever-changing financial system, powerful, rigorous and accurate credit-risk management processes and technology play a critical role in mitigating a lending institution's exposure.
With approximately 59 million consumer and small business relationships, 6,000 retail banking offices and more than 18,000 ATMs, Bank of America is among the world's leading wealth management companies and is a global leader in corporate and investment banking and trading across a broad range of asset classes.
The Corporate Investments Group (CIG) manages Bank of America's available-for-sale portfolio and is responsible for modeling and calculating the probability of default (PD) on the 9.5 million mortgages it services. In addition, the group calculates the market value, prepayment speeds and sensitivity to changes in interest rates and hedges these risks for the $19 billion mortgage-service-rights asset. Recently, CIG began assisting with the task of forecasting loan losses for the bank's credit card portfolio.
CIG had been using analytics from SAS for credit-risk modeling for many years, but with the addition of the credit-card loss forecasting responsibility, it was forced to reassess its use of an internal shared-services environment to run its modeling and calculation processes. Doing so would help reduce processing time, increase access and availability of resources for ad hoc analysis, while ensuring business continuity for this mission-critical function of the bank's business.
"We needed a solution that addressed today's business problems, as well as a solution with the flexibility for any future business requirements," says Russell Condrich, Senior Vice President, Corporate Investment Group. "Processing large, multi-terabyte datasets in a quick, efficient manner was a key requirement for us and SAS performed flawlessly. Without SAS, processing times would be longer, hedging decisions would be delayed and, ultimately, the bank would be behind the market."
To meet its performance requirements, the group moved its processing to a dedicated platform comprised of SAS®Enterprise Risk Management on SAS® Grid Computing, SAS® Scalable Performance Data Server on a 224 core IBM BladeCenter® grid and the IBM's XIV® Storage System. The initiative has already produced considerable results, such as reducing the bank's probability of default calculation time from 96 hours to just four. Processing time for ad hoc jobs has been reduced by 90 percent and, according to the CIG, they are processing at three times the speed of the previous environment.
The platform pulls data from eight systems of record (SOR), amounting to hundreds of millions of records, or 30 terabytes of source data, and allows the SAS environment to consume 3.9 gigabytes of I/O throughput per second from IBM's XIV storage environment. Approximately 30 users now have unfettered access to the environment, as opposed to the shared services environment of the past, in which user time was competitive and response times varied dramatically due to the high number of jobs being executed.
"We now have an environment that provides users with a robust platform on which to schedule and prioritize jobs, based on duration or computational requirements, so that ad hoc usage is not competing with scheduled work," says Stephen Lange, Managing Director, Corporate Investments Group. "This advanced grid platform is giving us unparalleled performance. SAS is indispensable for its unique way of handling large data sets."
As an example, Lange adds, "we have to score a particular portfolio of 400,000 loans with our suite of models, using multiple scenarios, and we need to run it over the 360 months of the mortgages' life. That process used to take three hours, now it takes 10 minutes because of the parallelization capabilities of the grid. The ability to go from three hours to 10 minutes on a job demonstrates a tremendous increase in our ability to deliver information and make decisions."