text:
Glee – The Rise and Fall of Sue Sylvester – Review
9 March, 2015 Barry Quinn
Barry Quinn
Barry Quinn is an English Language and Literature graduate and a Creative Writer MA studier. He is an aspiring creative and professional writer and is currently in the process of writing his first novel. His writing blog can be viewed here: https://barrygjquinn.wordpress.com You can follow him on Twitter at: @mrbarryquinn
Latest posts by Barry Quinn (see all)
TV Review: Doctor Who – Oxygen - 13 May, 2017
TV Review: Doctor Who – Knock Knock - 6 May, 2017
TV Review: Doctor Who – The Pilot - 17 April, 2017
Considering there are only three episodes (sob) left, does anyone particularly care that the Glee Club could end… again? You just know that Glee, a shown renowned for its positivity and upbeat nature, will end on a high, and that high will be the Glee Club triumphing against Sue, winning a load of awards, and (if the show flashes into the future, as most finales these days do) prospering with loads of members.
That said, 'The Rise and Fall of Sue Sylvester' was a hell of an episode. It was hilarious! And that was because it focused upon one of its best ever elements, something which has been missing in the past couple of seasons. Yes, the war between Sue Sylvester and Will Schuester was ramped up once more. Tenfold.
Dalton Academy burns to the ground this week. So? But it's convenient, yes, because it means that the Warblers can join forces with the New Directions so that the New Directions have enough members to compete. But I have two problems with this storyline (other than the fact that it is massively over the top). Firstly: Will was surprised when Blaine told him the news. Surely if a WHOLE school had burned to the ground it would have been on the news or something… just saying. And secondly: it was just too easy for the two Glee Clubs to combine. In Ohio, it seems, it's extremely easy to transfer schools. As if McKinley would have the room to accommodate all of these new students!
RELATED ARTICLE Becca Tobin's boyfriend found dead in hotel room
The highlight of episode 10 was the extended interview with Sue, in which we rehashed all of her bad deeds to date, including segments from the other characters. Joe returned, for all of one line! When was this filmed? Where is Joe now? What is he up to? Does anyone care? I certainly don't.
But it was hilarious and heartbreaking in equal measures, especially when Sue's mother, Doris, returned and said that she had never loved Sue. I'm not surprised that Sue punched the interviewer!
Sue is really having a raw deal this week, as she is also fired when Becky turns on her and reveals her hurt locker. I predict this will lead to a redemptive arc for Sue in which she'll try and earn Becky's love once more. Like Will and Rachel, this relationship is weird, owing to the fact that they are a teacher and former pupil, but Sue and Becky belong together. Even is Sue is downright dastardly to the Glee Club and Will, I hope she and Becky make up.
Doris' return went a lot better than I anticipated as she and Sue reconciled – sort of. Sue has always been a loner but it's nice to see people band around her, including Will (surprisingly) and Sheldon, who heartwarmingly states that Sue has helped him through a lot and that he appreciates her. Their relationship is pretty darn special, I think.
So what else? It appears as though the writers don't know what to do with Rachel, again. Miraculously she is given a Broadway part AND a place at NYADA all in the space of one day. How lucky that girl is! Personally I want her to return to NYADA, for now, and then the flash forward can show her achieving her dreams. For now she needs to be realistic, and an education will help her more in the long run than taking the shot on Broadway and potentially failing (again).
RELATED ARTICLE TV in 2015: A Year in Review
Sam isn't happy about her choice… hopefully this will lead to them splitting. I really dislike them together. Jonathan Groff returns next week, and why else should he return if not to reunite with Rachel? I'd accept them much more than Rachel and Sam!
About Barry Quinn
View all posts by Barry Quinn →
Barack Obama files brief supporting same-sex marriage
Introducing Naantali Spa, Finland
Love (Netflix): Why Gus is so toxic
Why you should be following Indya Moore
Rick and Morty Season 4 Episode 10: Star Mort Rickturn of the Jerri
Not as good as the book: adaptations versus their source material
TV review: Drag S.O.S. (Channel 4)
Game Review: Crash Bandicoot 4 – It's About Time
12 October, 2020 Jake Basford
'Crash Bandicoot 4 – It's About Time' is not only a useful moniker for the way the audience feels, but also hints at the plot. "Crash Souls" as has been dubbed by our Geek Editor is deceptively hard and necessarily so.
Opinion: Hogwarts Legacy – to buy or not to buy?
28 September, 2020 28 September, 2020 Jake Basford
Should you buy or boybott Hogwarts Legacy? The answer, as always, isn't straightforward.
23 December, 2020 23 December, 2020 John Preston
John Preston rounds up the absolute best albums of 2020.
Pat Reilly releases EP Prince of the Night
13 November, 2020 Kim X
LGBT musician Pat Reilly releases EP Prince of the Night.
Corn Exchange Manchester to mark fifth birthday by helping guests to celebrate missed occasions
27 August, 2020 7 September, 2020 Daniel Wren
To celebrate its fifth anniversary, the Corn Exchange Manchester is inviting its guests to share their stories of missed celebrations or to nominate deserving individuals to be granted a surprise Corn Exchange treat.
Full programme for Alternative Manchester Pride Festival published today
26 August, 2020 26 August, 2020 Simon Blish
Manchester Pride has today released the schedule for its Alternative Manchester Pride Festival over August bank holiday weekend.
Copyright © 2020 Vada Magazine. All rights reserved.


Added by Alex Last about 9 years ago. Updated 2 months ago.
Since we have "subtasks" now, it would be better to (optionally) show a tree of issues in the "Roadmap" instead of a list of issues.
Is there an overall design ready how subtasks will affect the user interface in general?
Why this ticket is closed?
Is there any plan to implement this request?
Are there plugins (compatible with the latest version of redmine) providing this feature?
This is in some way related to #7907. IMHO, the ticket list in the Roadmap should be replaced by - or at least made more similar to - the "normal" ticket list.
I propose to change the order of issues in the roadmap in ascending order of Parent task.
Currently, issues on the Roadmap page are sorted by tracker_id. You can see an example on https://www.redmine.org/projects/redmine/roadmap. As a committer of Redmine, the order is convenient. This is the similar order with the Changelog.
But the patch change_roadmap_issues_to_tree_structure.patch sorts issues by issues.id. I don't like the order.
I applied the patch provided in #5275-19 and found it extremely helpful. It's not clear to me why it would be a desirable behavior to order by issue number; the order in which an issue is created (and thereby receives a number) has no necessary and sufficient bearing on due date nor relationships with other trackers, which seem like defining characteristics of a roadmap.
A cursory google search seems to indicate that this is a highly requested feature, and Mizuki ISHIKAWA's solution seems to work. Thanks very much.


text:
Start Learning Now!
Operations & IT
Concepts Team
BrandGuide
Food & Bev.
College Coordinators
Fun&Facts
Top Brand Lists
Fin Wizards
Marketing Gurus
GD Topics
Internship Stories
India as an Investment Destination - Opportunities for Tomorrow
Posted in Finance Articles, Total Reads: 1496	, Published on November 02, 2015
The rapid expansion of the capitalist system and the encroachment of industrial economies in the orient world 20-25 years ago were seen as the first signs of the rise of a new world order. The tectonic plates are shifting and the East is rising. The growth of India and China in two different yet successful economy has aroused the curiosity of the Western world. China with political centralisation and economic devolution has developed into a highly efficient manufacturing economy while India has evolved into a vibrant socioeconomic ecosphere. That is primarily the reason why India has been receiving huge inflows of foreign investments even when currently the overall economic rating of the country is under stress.
India was forced to open up its gates to the outside world in 1991. But the country felt the surge of globalisation only after the Asian financial crises of 1998 exposed the structural weakness of South Asian economies. Investors were looking for a politically stable, economically robust economy that was cheap to invest into. India was looked at as the new kid on the block and with some conglomerate powerhouses already dominating the Indian market, niche sectors got a lot of foreign capital at a risk premium. The Indian IT industry was already making headwinds in the US and with that Investment started building up in the Indian financial markets.
Image: pixabay
The growth of foreign investments in India both as direct and indirect route has grown exponentially over the last 15 years. The FDI 2014-15 stood at $ 37.75bn, remarkably greater than $ 4.75bn a decade ago. After the global recession and the sinking of Euro and US capital markets, hot money has also poured in India in the form of FII's have gone up considerably. This also presents a systemic risk management problem as outflow of capital will also result in violent exchange rate fluctuations. India is on the path to recover from the slowdown and thus presents a lot of opportunities for investors to take a part of the pie. The startup culture is now booming with the number of entrepreneurial ventures coming out in the past year is 5 times that of a decade ago. This presents a unique opportunity for investors to gain above market return and to invest in high risk equity assets.
There is also a major shift towards driving growth in the manufacturing sector. India has been a predominantly services based economy and if manufacturing picks up, the services industry will be pushed up further by the cascading effect. Norms for investment in different sectors are being relaxed to accommodate foreign players. Also a general policy of divestment is being followed by successive governments which is a long term move away from government controlled business. As such, that will create a vacuum to be filled by both Indian and foreign players. Technology and Infrastructure are the sectors where foreign investment could be a game changer.
The Indian economy has responded well to the foreign inflow of capital. Some sectors however, have performed above expectations and have become the flag bearers for foreign investment. Technology sector has seen a drastic appreciation by foreign investors with the highest share of FDI in India at about 23% to the sector. India brewed IT firms like Infosys, TCS and Tech Mahindra enjoy a high portfolio investment factoring directly into their stock valuations. Now with new technologies coming up and these companies gearing up for a shift from service based to product based offerings, the scale and in turn the bottom-line of the sector is expected to go north. This in turn will lead to an aggressive increase in the capital inflows. The e-commerce industry is already experiencing such a flux with companies that have existed for less than 4-5 years, still have cash flows in negative, raising foreign capitals in millions with relative ease. So with the economy on the track of improvement, the technology sector is expected to burgeon on the back of strong capital inflows, both domestic and foreign.
Infrastructure is another sector where India presents huge investment opportunities. The appetite of the country for highways, ports, airways, electricity is huge and growing. India required around US $ 1 trillion in the 12th five year plan (2012- 17) to fund infrastructure growth. A global survey by Ernest and Young has ranked India as the most attractive investment destination followed by Brazil and China. This presents a huge opportunity for foreign investors to take part in a long term high yield business.
Prime Minister Narendra Modi himself has shown great support for infrastructure improvement across the country. The administration, which has a backlog of more than $100mn of stalled projects, plans to spend more than $ 20mn this year on infrastructure. Moreover, capital requirements have been reduced for private airport developers, GOI has agreed to pay 40% of public private highway development. Many major steps are being taken to improve ease of business in the country. A lot of focus has been made in recent months to improve the investment environment in India. An array of steps have been taken to provide an uplift to the image of India as an investment destination in Infrastructure.
The efforts of the government are rooted in the fact that there are huge gaps in the supply and demand when it comes to Infrastructure. In some cases the conditions are getting worse. The Power sector is facing a major crisis and requires huge investments. Similarly highways and ports are currently in dire state in some places and require major investments. Airways, Railways, Digital Infrastructure, Sanitation all require substantial fund in order to pull them out of this gloomy situation. This may be a grim representation of India's infrastructure state, but for investors these gaps present huge investment opportunities. The gaps are too huge to be filled by the government alone. Initiatives like Digital India is a signal for all the investors to invest heavily in this domain. Similarly, other areas like power sector, highways present lucrative opportunities for the investors to be a part of the growth trajectory of India while increasing the bottom-line for themselves.
India has been a favourite destination for investors for quite some time now. Even today when economic scenario has been clouded by the gloom of slowdown and territorial conflicts, India remains one of the few bright spots. India provides investors with a market, a robust democracy, stable environment and an opportunity to grow at a fast pace. A relationship of symbiotic nature can evolve considering the opportunities that India as an investment destination provides and the purpose of investment that capitalists can bring in. Some of the glitches do remain and some of the red tape still needs to be cut down. Thankfully Indian government is working to remove these hiccups in a proactive manner. All these factors show that India is a market with excellent opportunities for all the investors out there in the global market. A market where investors can invest, grow and contribute to the country as well.
This article has been authored by Saurabh Pandey from XLRI Jamshedpur
If you are interested in writing articles for us, Submit Here
Related Business Articles You May Like:
Maximizing Business by Maintaining a Healthy Talent Pool
Evaluating Opportunity Loss in Business
Growing Business through Customer Funnels
Impact of Digital SCM in Modern Business
Business Strategy in a Digital Age
Become a contributor & write business contentSubmit Content
Quizzes & Skills!
Management Quizzes
Skills Tests
Quizzes test your expertise in business and Skill tests evaluate your management traits
Related Business Content
Break Even Point
Inventory Costs
Sales Quota
Top Companies Lists
Top 10 Global Mobile Phone Brands
Top 10 FMCG Companies in World
Top 10 IT Companies in World
Top 10 Car Brands in World
Top 10 Telecom Companies in World
Top 10 Electronics Companies in World
Top 10 IT Companies in India
Top 10 Pharma Companies in World
Top 10 Insurance Companies in World
Top 10 Apparel Brands in World
Top 10 Banks in World
More Lists
All Sections on MBASkool
Fun & Facts
Finance Articles
India's Journey with Demonetisation
Walmart Flipkart Acquisition Deal Redefining Indian eCommerce
Tariff on Chinese Imports by USA leading to Global Trade War
Marketing & Strategy Articles
Customer Metrics for Enhanced Marketing
Live Video Marketing- Influencing Customers Real-time
Operations & IT Articles
Emergence of AI in Healthcare
Big Data Analytics – Netflix Case Study
Can Artificial Intelligence Replace Doctors?
Inclusive Workforce using Workplace Diversity
Designing People Solutions for Future Business Landscapes
Connecting Employees Across Geographies
Explore MBASkool
IT & Tech
Lifestyle and Retail
Operations & SCM
Ops Champs
HR Heros
Insurance Companies World
Consumer Electronics Companies
FMCG Companies World
Car Brands World
IT Companies in the World
Global Mobile Phone Brands
Popular for MBA's
2011-2019 | MBASkool.com
Original Template You! Bumpit! by Youjoomla.com Copyright © 2008 All rights reserved

redpajama_set_name: RedPajamaCommonCrawl


How Far is Trifecta Starlight?
This premium apartment complex comes with the assurance of providing residents a taste of high standard urban living. Each of the 2 and 3 BHK apartments features great interiors, best amenities, ample natural lighting, and ventilation as well as sophisticated fittings and accessories. The project promises to offer the best of both worlds with its ideal location at Mahadevapura, which is a rapidly developing neighbourhood in Bangalore.
USP: Well-planned structure with thoughtfully designed units.
All plumbing lines shall be pressure tested.
Backed by over a decade of experience in the construction sector, we at Trifecta have learned a thing or two.In an imperfect world, we have to try harder.Sure we could make grandiose promises like everyone else, even throw in a luxury car or two, but trivialising one of the most important decisions you will ever make is the last thing we want to do.
We are earnest and we listen. We try and do our best to deliver what you want. If at all you have to compromise somewhere, you are never the last to know. We take our word seriously, and will not promise you what we cannot deliver.At Trifecta, we are balanced and with balanced people, you know you are in good company.
Trifecta Projects is a brand owned by Ecstasy Projects Pvt. Ltd.Ecstasy Projects was started by Mr. Subba Reddy and Ms. Sarada Reddy who sought to bring joy and happiness to an otherwise tarnished and jaded industry.The idea was simple, the task even simpler.
Just be ourselves.Given that we are straight forward and bound by a strong sense of principles, we decided to practice our values in our business.Basically, walk the talk.We chose to do things the right way, even if it was not easy or cost-effective. We chose to do our best and not make promises we cannot keep. We chose to be accountable and we are reachable, anytime night or day, to answer your questions. It was from these ideals that Trifecta was born.


text:
Check the Labels
https://www.smartertimes.com/1559/check-the-labels
One of the most egregious ways that the New York Times demonstrates its liberal bias is by slapping the label "conservative" on conservative news outlets and think tanks, while omitting the "liberal" label when describing liberal news outlets and think tanks.
One recent example comes in a James Stewart column about tax reform in the District of Columbia. Mr. Stewart refers to "the conservative website The Daily Caller" and "conservative supply-side advocates like Grover Norquist, the president of Americans for Tax Reform." But "the Urban-Brookings Tax Policy Center" gets no ideological label from the Times. Nor does its senior fellow, Steven M. Rosenthal.
Another recent example was a Times news article that refers to "the conservative Washington Examiner" but that also mentions and quotes the president of the Brennan Center for Justice at New York University without mentioning that institution's ideological leanings.
Does the Times really think its readers are such delicate flowers that they need to be warned in advance of the risk that they might be exposed to a conservative opinion? If the Times feels the need to apply these ideological labels, the least it can do is be even-handed about it. Otherwise people might want to start referring to the paper as "the liberal New York Times."
Related Topics: Politics receive the latest by email: subscribe to the free smartertimes.com mailing list


text:
Jacques Adrien Savoye (* 12. November 1905; † 17. März 1998) war ein französischer Unternehmer und Autorennfahrer.

Singer und Morgan
Jacques Savoye war in den 1930er-Jahren Verkaufsrepräsentant der britischen Automarke Singer in Frankreich. Jacques Savoye Automobile in Paris vertrieb neben Singer-Fahrzeugen auch Modelle von Alvis. Singer 9 Le Mans wurden in kleiner Stückzahl zu Singer 9 Le Mans Replica Savoye Spezial umgebaut. 1954 wurde Savoye zum ersten Morgan-Importeur Frankreichs. 1995 übernahm sein Enkel Pierre-Henri Mahul das Unternehmen.

Karriere als Rennfahrer
Jacques Savoye war mehrere Jahrzehnte als Rennfahrer aktiv, wobei er vor allem beim 24-Stunden-Rennen von Le Mans am Start war. Sein Debüt gab er 1935 gemeinsam mit Guy Lapchin auf einem Singer 9 Le Mans und mit dem 23. Rang in der Endwertung. Vor dem Zweiten Weltkrieg fuhr er in Le Mans ausschließlich mit Singer-Modellen, die in seiner Werkstatt in Paris auf den Renneinsatz vorbereitet wurden. 1938 wurde er Gesamtachter und feierte einen Klassensieg.

Nach dem Zweiten Weltkrieg nahm Savoye 1949 den Rennsport wieder auf und bestritt das 24-Stunden-Rennen bis 1955. Seine letzten Renneinsätze hatte er 1969. Im Alter von 64 Jahren fuhr er einen Morgan Plus 8 bei der Tour de France für Automobile und wurde 17. der Gesamtwertung.

Statistik

Le-Mans-Ergebnisse

Einzelergebnisse in der Sportwagen-Weltmeisterschaft

Literatur
 Christian Moity, Jean-Marc Teissèdre, Alain Bienvenu: 24 heures du Mans, 1923–1992. Éditions d'Art, Besançon 1992, ISBN 2-909-413-06-3.

Weblinks

 Jacques Savoye bei Motorsport Magazine
 Jacques Savoye bei Racing Sports Cars
 Jacques Savoye bei der Driver Database

Einzelnachweise

Rennfahrer (Frankreich)
Rennfahrer der 24 Stunden von Le Mans
Sportwagen-WM-Rennfahrer
Unternehmer (Frankreich)
Franzose
Geboren 1905
Gestorben 1998
Mann

redpajama_set_name: RedPajamaWikipedia


Free Membership Software from Enjay.
15th August 2018, Enjay celebrates the 19th anniversary by giving away a free association membership software. Not a lite version, this is full fledge Solution. This is Enjay's way of giving back to the Society, a kind of CSR Activity.
More and more non-profit organisations are bringing in great professionalism in their working. They use IT even better than business houses.
Any Association or Club or NGO requires some infrastructure to manage itself. In current times, it has to be an intelligent software. It cannot be a spreadsheet or a simple database structure. Hence we customised Enjay CRM to one of the best membership CRM software for Associations and Clubs.
Enjay's Membership Management is already being used by many different Associations. Its a perfectly baked, ready-to-use product. We are giving this as Free as it is. Its not a lite version, its a full fledged Solution.
Linking with existing Website of Association.
Communicate via Email/SMS/WhatsApp (individually and in bulk).
Separate Companies and person module store all the relevant information required.
Manage the entire process of inducting a new member. Right from registration to fees collection to approval from board etc.
Membership renewal and fees collection process is managed.
Emails, SMS, WhatsApp & meetings. SMS, WhatsApp and Email Templates make communications fast and easy.
All membership documents can be stored in digital format. Eg: Registration form, Statutory documents, GST details etc.
Manage year wise board details with designation and tenure.
Manage all the information regarding speakers and sponsors.
Mobile Dashboards with a detailed reporting tool on the browser front.
Probably the only Free Membership software with Native mobile App support.
Basically, it will handle all the activities of any association, Club or chamber of commerce, or any kind of organisation. The features mentioned here are only a small set of actual features. Since it is based on Enjay CRM, any kind of new functionality can be easily added or modified.
Complete information and history of Members.
No limitation on fields. Entire membership database with all the details is in one place.
Manage different membership levels if required.
Can handle different types of membership options. Unlimited levels of membership. The unlimited categorisation of the member list.
Keeps track of membership fees received and pending.
Reminders for membership renewals. Can send emails directly from the system. Automated birthday and anniversary reminders. Unique Automated and manual Email Marketing functionality included.
Keep information not only about members but also about their family members, their birth dates, anniversary etc.
Can be linked with the Association website. When someone applies for membership, there is an automated entry in Membership management software. IT can trigger necessary automated workflows (sending emails to him & board etc).
Store professional information of Members, period wise. Eg., Mr X might be CTO in some organisation, but then he might change to the CEO in some other organisation. Membership Management Software keeps track of all the activities.
Store profile of members based on tags, this makes easy to do targeted searches and reporting.
Unlimited levels and types of sponsorships.
Track the events or conferences done by them.
Can keep track of meetings, attending members.
Option to attach minutes of meetings, even photographs.
Also can allow all the office bearers to log in to the system and manage their own tasks and work. A Perfect Team management tool.
Includes basic project management also.
Can handle multiple chapters (branches) of any associations. Since it is web-based, it can be accessed by geographically spread teams.
Access Control levels, for allowing different access control to different teams.
The legendary strength of Enjay CRM for reporting is matchless.
Schedule reports getting informed automatically about the current status.
No installations. No investment in hardware, no Capex. Simple and secure cloud-based solution.
If you have a large number of members, donors or devotees, integration with telephony becomes a great advantage.
Councils like Export Promotion Councils.
Religious groups – like Temple, Mosque, Church, etc.
In short, its a complete and easy membership management software. Please share your comments/views/suggestions on this. We are eager to hear from you.
How do I download this software?
You please fill up the form there, our team will contact you.
The tool works exceptionally fine as described in the post.


In prison, each participant works one-to-one with a case worker to talk about the difficulties they face and to set personal development goals. They then work with their case worker to achieve these objectives. This is done through education, skills development and other targeted projects.
On release, participants continue to be supported and are helped as they pursue their education and employment aims. Where necessary, participants are given mentoring in areas such as relationships, housing and personal development to ensure they are able to progress.
Passport Polmont supports young people in HMYOI Polmont who, on release, will be returning to live in Edinburgh, Glasgow and Lanarkshire.
The project works with participants for a minimum of six months before they are due to be released. This provides enough time for each individual to fully benefit from the project's support. On release individuals are supported for a minimum of a year.
The project helps those who have been through the prison system integrate back into their communities and move on with their lives. It provides opportunities for college visits, links to key support services, advice and information and access to college courses, volunteering placements and funding support.
Passport Polmont is delivered at HMYOI Polmont. After a participant is released from custody, support is delivered in the community in Edinburgh, Glasgow and Lanarkshire.


Strategic CG placement and lighter swingweights help square the face.
A key advancement in the G Le fairway wood was giving it a lower lead edge to help the face slide under the ball, making it far easier to contact the ball cleanly and launch it off the grass or a tee.
We made the heads highly forgiving by thinning the crown and redistributing weight to locate the center of gravity lower and deeper to increase the MOI. The strategic CG and a lighter swingweight will also help you square the face to deliver the ball on target. Crown turbulators can help frame the ball and assist with alignment.
The G Le fairway series comprises 3-, 5-, 7- and 9-woods to give you flexibility in your shot selection. A mint PING ladies logo and a navy-mint color scheme across the G Le family help give the products their own distinctive flair.


Explore these easy-to-read health education materials below. The resources, which include topics such as lead awareness, home safety and injury prevention, and mental health, can be given to both parents and staff. Find useful information and basic tips that parents and staff can easily understand.
Lead is toxic to everyone, but unborn babies and young children are at greatest risk for health problems from lead poisoning. Unsafe levels of lead in blood can lead to a wide range of symptoms and can also affect a child's developing brain. Share this brochure with parents and staff to inform them about how to avoid lead exposure.
Young children have the highest risk of being injured at home because that's where they spend most of their time. The majority of childhood injuries can be predicted and therefore prevented. Supervision is the best way to prevent injuries at home but even the most prepared parents can't keep kids completely out of harm every second of the day. This brochure can be shared with parents and staff to inform them of how to reduce injuries at home for their children.
Stress is a part of life. Yet, too much stress can have negative consequences. It can cause health problems and can make parenting more difficult. Caregiver stress can even contribute to children's challenging behavior. This brochure identifies some easy-to-use stress reduction and self-care tips. It can be shared with parents and staff.
Parental depression is common and it is particularly common among Early Head Start and Head Start families. Parenting is challenging for every parent, at times; however, for parents experiencing depression it can be extremely difficult. It can be hard for parents experiencing depression to provide responsive, consistent, and sensitive care. When a parent is depressed there is an increased risk of his or her child having behavioral, emotional, or cognitive problems. Seeking support to address depression can make a difference in the life of a parent and a child. This brochure can be shared with parents and staff to offer information about depression and strategies to seek support for concerns about depression.
All children misbehave or exhibit challenging behavior sometimes. How a parent responds can make a big difference in how a child develops. Treating a child with kindness and respect helps him or her treat others with kindness and respect. Parents who nurture themselves and their children are teaching their child positive lifelong skills. Share this brochure with parents and staff to provide tips and tools to positively respond to children's behavior.


text:
Gerhard Opelz
All TTS eyes are focused on Berlin, the venue of the 24th International Congress of TTS held on July 15-19, 2012. The international program committee has lined up first-rate plenary speakers, along with the highest-scoring peer reviewed abstracts for oral presentations. We look forward to an outstanding congress program, with top-level presentations from all fields of clinical organ transplantation as well as the transplant-related sciences. It is a pleasure to welcome the world community of transplant professionals to Berlin.
As my term as President of TTS comes to an end, I look back on two interesting years that have brought multiple challenges. TTS has evolved to a membership of over five thousand, has become recognized as the world's leading society representing organ transplantation, and is interconnected with many related professional societies and authorities. Upholding the ethical standards of organ transplantation has been at the center of TTS attention through its close relationship with the Declaration of Istanbul Custodian Group. In addition, educational and training activities, international support functions (especially in countries in which transplantation is still in a developing phase), interaction with regulatory authorities and industry, and last but not least, the important scientific activities of the TTS Committees and Sections have rounded off the society's work during my term.
I have especially enjoyed seeing the development of the new TTS registry initiative in collaboration with the scientific CTS registry. Although this project is still in its infancy, it is gratifying to know that even in the short to medium-terms, many transplant centers around the world in need of documentation will benefit from this program. And in the long-term, a truly worldwide reference source of transplant data for scientific analysis and evidence-based guidance will eventually emerge as a result of this effort.
Throughout my presidency, I was fortunate to have been supported by an extremely cooperative Executive Group and society Council as well as a most competent staff at TTS International Headquarters. Altogether, there is much optimism for the future of this society. Already, plans for the TTS Congresses in 2014 in San Francisco and 2016 in Bangkok are taking on concrete shape, and the long list of activities in which TTS plans to be actively involved in the coming years fills megabytes of computer memory space. I am confident that TTS will continue to serve the world transplantation community well.
New TTS Council Members
TTS would like to thank its members for voting in the recent elections of TTS Officers and Councilors for the term 2012-2014. We are pleased to introduce your new Council.
Congratulations to the newLY elected officers and council members.
New Officers and Councilors
Henrik Ekberg COUNCILOR
Shiro Takahara
(Asia) COUNCILOR
Rudolf Garcia-Gallont
(Latin America)
SENIOR TREASURER *
Marcelo Cantarovich COUNCILOR
Vivekanand Jha
(North America)
John J. Fung COUNCILOR
Dirk R. J. Kuypers
(Europe) COUNCILOR
Gabriel Danovitch
Returning Officers and Councilors
Ron Shapiro COUNCILOR
Vasant Sumethkul
Nancy Ascher
COUNCILOR
Annika Tibell
(Middle East / Africa)
Ribeiro de Castro
(Latin America) COUNCILOR
Philip O'Connell
(Oceania)
Incoming President's Remarks
Francis Delmonico
TTS: An Engine of Change
The Transplantation Society has undergone an enormous transformation in recent years. Its membership has increased to over five thousand professionals in nearly one hundred countries with transplantation services around the world. As a non-governmental organization (NGO) of the World Health Organization (WHO) in matters of organ donation and transplantation, TTS has been an effective ally to the WHO, achieving international standards of care that were adopted by the World Health Assembly in May 2010. The charge of the Declaration of Istanbul not only seeks to prohibit organ trafficking, transplant tourism, and transplant commercialism, but also to foster deceased donation and ethically proper practices of live donation throughout the world. TTS support of the Regional Health Development Center (RHDC) of Croatia in establishing deceased donor transplantation throughout Southeastern Europe is an example of that effective interaction. Recently in Montenegro, TTS and the RHDC leaders Dr. Mirela Bušić and Lydia Raley visited ministry officials Dr. Jadranka Lakićević and Dr. Mira Dašić, as well as Mirjana Djuranović, Senior Adviser for International Cooperation, all shown in the adjacent photo.
A well-developed action plan is underway with the alliance of the Ministry of Montenegro and the experienced leadership of Professor Marina Ratković. Key components have been identified that will enhance success—among them, the capacity to determine death by neurologic criteria in the Intensive Care Units of the University Hospital of Montenegro and the engagement and commitment of the Director of the Hospital to assemble a multidisciplinary team to conduct the donation and transplantation program.
TTS is currently entering a period of activity that will be unmatched in its intention to support all jurisdictions in their efforts to expand deceased organ donation.
The principles and proposals that were established in Istanbul in May 2008 have become the cornerstone of the revised WHO Guiding Principles, urging all member states to address their donation and transplantation needs. TTS is currently entering a period of activity that will be unmatched in its intention to support all jurisdictions in their efforts to expand deceased organ donation.
On behalf of the Officers and Councilors of The Transplantation Society, we wish to convey our appreciation to Gerhard for his stewardship of the Society during the past two years and for his continuing role as an Executive of Council in the years ahead.
This issue of Tribune presents several examples of how TTS fulfills its mission.
The TTS Congress in Berlin will be a great networking event full of news of exciting developments in transplantation. While we will be travelling through the old airport, we will be heading for new knowledge. The plans for the 2014 TTS Congress in San Francisco, which will be the second World Transplant Congress in collaboration with the American Society of Transplant Surgeons and the American Society of Transplantation, are well under way (see Berlin is Prepared for the Best in Basic Science and Clinical Transplantation on pages 6 and 7 and Announcing the 2014 World Transplant Congress on page 9.)
Between the 2012 and 2014 Congresses, TTS will have its alternate year program with specialized interest meetings and TTS sections' meetings. These events will gather together physicians and scientists in cell- or xenotransplantation, intestinal, hand and composite tissue, pancreas and islets, as well as specialists in organ donation and transplant infectious disease (see updates from the CTS, IHCTAS, IPITA, ISODP, ITA, IXA and TID sections on pages 10, 13-15.)
TTS is also focusing on supporting colleagues in the forefront of research in Transplantomics and Basic Science (see Transplantomics 2012 La Jolla Conference Report on page 11, and Basic Science Committee Update on page 5.)
TTS membership benefits are very substantial: simply by attending one of our many meetings every two years you will save money, but you may be able to profit even further through the Mentor/Mentee programs of the TTS Basic Science Committee and TTS Women in Transplantation initiatives, as well as TTS Research Exchange Fellowship grants, to name a few opportunities.
If you take a look at www.tts.org you will see not only news of the society, its sections and the affiliated national societies but also a sector dedicated to continued education. All sessions in TTS meetings and congresses are recorded and may be viewed by TTS members at any time. Additionally, all our webinars may be revisited—one of the most recent webinars concerned the teaching and training of junior transplant physicians. This topic was addressed by Dr. Medhat Askar in a webinar format and will be explored again at the Berlin Congress in Room 42 of the ICC Berlin on Thursday, July 19th from 8:00 to 9:00am.
TTS' position on the development of an ethical basis for organ donation and transplantation world-wide is well known. The Declaration of Istanbul (DOI) has now been endorsed by more than 110 organizations and societies in the field. TTS continues its close collaboration with the DOI Custodian Group (please see Declaration of Istanbul Custodian Group Update on page 8.) TTS also supports the China Liver Transplant Registry (CLTR) in its endeavours to increase deceased organ donation (after circulatory or brain death), replacing executed prisoners as donors (see TTS Supports China Liver Transplant Registry Efforts to Align Chinese Practices with International Standards on pages 8 and 9.)
TTS actively supports the intensive work in the South East European Health Network (SEEHN) led by the Regional Health Development Center in Croatia (RHDC) for the past two years (see Macedonia Meeting Highlights in Tribune Vol. 8 Issue 3, Nov. 2011.) Meetings are scheduled in each country (for example in Montenegro, see Incoming President's Remarks, page 3) and in June 2012 a Symposium took place in Zagreb with participation from all Ministers of the countries in the region (see report to come in a future issue of Tribune.)
All sessions in TTS meetings and congresses are recorded and may be viewed by TTS members at any time.
TTS has also continued to support the development of deceased donation in Thailand (see TTS and Thai Societies Launch a Model of Collaboration in Tribune Vol. 8 Issue 1, Apr. 2011), and I participated in a one-day meeting on March 18th with the Thai Transplantation Society in Bangkok under the leadership of Vasant Sumethkul, Councillor of TTS and President of the Thai Transplantation Society. Reimbursement for donor hospitals in Thailand has been accomplished, and trauma centers that are potential centers of excellence in organ donation have been identified. Educational programs for intensive care personnel are also being planned.
Dr. Mehmet Haberal, former TTS Councilor, Founding President of Baskent University, and a Member of the Turkish Parliament, remains in prison without trial in Turkey for more than three years now. TTS Immediate-Past President Jeremy Chapman, past Councillor Josep Lloveras and Dr. Nadey Hakim visited Dr. Haberal in the Silvri Prison outside of Istanbul in April and reports that he is well but disheartened by his long incarceration. Continuing efforts are being made to bring this state of affairs to the attention of governments on both sides of the Atlantic.
Anita Chong and Stefan Tullius,
Basic Science Committee Co-Chairs
Transplantation has not stopped moving forward and the field remains exciting, largely based on its progress in basic, translational and clinical research. The 2012 Berlin TTS Congress received close to three hundred abstracts in the categories of Immunobiology and Basic Sciences, a record high. The most recent and outstanding research will be presented in seventy-six Oral and Mini-Oral presentations. In addition, leading investigators in their field will present the most cutting-edge advances in basic transplantation research in eight State of the Art and eight Sunrise Symposia, providing the most up-to-date information and ideas for new research directions.
The Basic Science Committee is continuing its collaboration with seven national and regional transplant societies to award up to thirty Mentor/Mentee Travel Awards for the Berlin Congress. We will also be awarding for the first time several TTS—Basic Science Research Exchange Fellowship grants to provide new research opportunities for trainees and established investigators away from their home institutions. Both the mentor/mentee awards and the research exchange fellowships will be awarded during the Basic Science Networking Event on Tuesday, July 17th from 17:30-19:00 at the ICC Berlin in the Oslo Room.
We are awaiting this exciting 2012 TTS Congress, anticipating the excellent basic science presentations and most importantly, looking forward to seeing you at the networking celebration. Berlin is a wonderful, hip, metropolitan place, so we are sure that you will enjoy the city as well.
Berlin Is Prepared
For the Best in Basic Science and Clinical Transplantation
Immunologist Leslie Baruch Brent
will be honored during the
2012 Berlin Congress
Welcome to the 24th International Congress of The Transplantation Society. After many exciting months of congress preparation, we are delighted that you made it to Berlin, one of the most thrilling cities in Europe. Take part in—and be the most important part of—this trend-setting scientific meeting.
The meeting will start with the Postgraduate Weekend on July 14-15, 2012. We are looking forward to discussing current controversial topics in the fields of allocation, surgical procedures and immunosuppression. Concurrent workshops on Saturday will elucidate clinical and immunological issues from concepts of chronic rejection to innate immunity. Sunday's schedule includes a variety of topics presented by outstanding international transplant experts, including "How to make a career in transplantation"—a session that will be of particular interest to young scientists and physicians, and a session with answers and practical tips on the crucial subject of "How to fund research in transplantation."
The Opening Ceremony on Sunday, July 15th will introduce you to the International Congress Centre Berlin (ICC Berlin), one of the largest, most advanced and most successful congress venues in the world. The evening's entertainment, provided by The Berlin Comedian Harmonists will take you back in time to the era of the Golden Twenties. You will not want to miss it!
The Kulturbrauerei building, site of the
Congress Gala Event
(Copyright Palais Veranstaltungs GmbH)
You also shouldn't miss the Welcome Reception, which will be held in the Exhibition Hall after the Opening Ceremony. Use this great opportunity to meet your fellow conference attendees, greet long-standing companions, and make new friends.
The main congress will offer a versatile and exciting scientific program spanning disciplines from clinical transplantation to basic science. Worldwide-established experts will present the latest results of their research in twenty-six Sunrise Symposia and thirty-seven State-of-the-Art Symposia, giving a comprehensive overview of the field of transplantation. Extraordinary highlights will be presented in six Plenary Sessions.
More than two thousand abstract submissions have been received for fifty Concurrent Oral Sessions, forty Mini Oral Sessions and an extensive Poster Exhibition. Each poster in the exhibition will be printed on-site and displayed in the traditional printed format. In addition, convenient Poster Lounges will provide electronic poster displays to promote a scientific exchange in a communicative atmosphere. The Mini Oral Sessions will build bridges between conventional poster presentations and full oral presentations.
The President's Plenary on Wednesday, July 18th will feature the 2008 Nobel Prize Laureate Harald zur Hausen, who discovered the role of the human papillomavirus in the development of cervical cancer. Professor zur Hausen will give an outstanding presentation on oncogenic viruses.
The famous bust of Queen Nefertiti
will be on display at the Neues Museum
during a special viewing
for Congress delegates
(Büste der Königin Nofretete,
Neues eich, 18. Dynastie
Amarna-Zeit um 1340 v. Chr,
Kalkstein und Gips,
© Staatliche Museen zu Berlin,
Ägyptisches Museum
und Papyrussammlung,
Foto: Jürgen Liepe)
TTS President Gerhard Opelz will give his presidential address prior to honoring the awardees of the Young Investigator Awards, the Recognition Awards, and the Medawar Prize.
A special homage will be paid to Leslie Baruch Brent. Leslie Brent, born in Köslin, Germany (now Koszalin, Poland) escaped the Holocaust and is one of the co-discoverers of acquired immunological tolerance.
The Cultural Evening will be very special: On Tuesday, July 17th, the UNESCO World Heritage site Museumsinsel (Museum Island) will open the doors of two of its most interesting museums for TTS Congress delegates only. The first will be the Neues Museum (New Museum), an institution with a history as rich as the Museumsinsel itself. Having been closed for almost seven decades, it was finally revived by the British architect David Chipperfield, who succeeded in uniting the structure's old glory with modern elements. The museum is home to one of the world's most important collections of Ancient Egyptian artifacts, including one of the most graceful pieces of art worldwide: the bust of Queen Nefertiti. The second museum that will be open for TTS delegates only is the Pergamon Museum, one of Germany's most successful art museums. It houses some of the most impressive original-sized monumental buildings of the Middle East, among them the Pergamon Altar.
The Gala Event at the Kulturbrauerei will be held on Wednesday, July 18th. Nothing could be a better venue for a social evening than this former brewery building where diverse artists from Berlin will attract, entertain and animate Congress guests. Musical delights will range from traditional popular dance tunes from the roaring 20s, 30s and 40s by the Capital Dance Orchestra, to alternative dance music, to a classy swing band to drum beats. The participants will be able to explore the many different rooms and courtyards of the venue while they sample culinary offerings representing the countless nations that find a second home in Berlin: from kebab to sushi to falafel to sausage.
Once again, on behalf of The Transplantation Society and the Deutsche Transplantationsgesellschaft, we welcome you to Berlin and to the 24th International Congress!
The Transplantation Society Awards
2012 MEDAWAR PRIZE
The Medawar Prize recognizes the world's most outstanding contributions in the field of transplantation. It is funded from a generous endowment by Novartis Pharma AG to The Transplantation Society (TTS). The 2012 Medawar Prize recipient will be announced at the TTS Presidential Plenary and added to an illustrious group of 27 previous Medawar Laureates.
2012 TTS RECOGNITION AWARDS
Recipients of the 2012 TTS Recognition Awards will be announced at the TTS Presidential Plenary.
• TTS-Asturias Award for International Cooperation
• TTS-Genzyme Award for Education and Training in Transplantation
• TTS-Genzyme Award for Innovation in Surgery and Technology
• TTS-Novartis Award for Outstanding Contribution to the Evidence Base for Transplantation
• TTS-Novartis Award for Outstanding Investigator Driven Clinical Trial
• TTS-Roche Award for Outstanding Achievement in Transplantation (Basic)
• TTS-Roche Award for Outstanding Achievement in Transplantation (Clinical)
• TTS-Roche Award for Excellence in Translational Science
• TTS-Roche Award for Transplant Infectious Disease
• TTS-Roche Award for Worldwide Impact in Transplantation
2012 TTS YOUNG INVESTIGATOR AWARDS
Ten TTS Young Investigator Awards will be presented to TTS Members with the highest scoring abstracts during the Berlin Congress. These awards will be presented during the TTS Presidential Plenary.
TTS Supports China Liver Transplant Registry Efforts to Align Chinese Practices with International Standards
Participants of the national assembly convened in Hangzhou, China in March 2012
The China Liver Transplant Registry (CLTR) is underway in establishing much needed changes in China. Representatives of TTS (Francis Delmonico and John Fung) recently participated in a national assembly sponsored by the Ministry of Health and the Red Cross of China, convened in Hangzhou in March 2012. An invited keynote presentation was made by Dr. Delmonico on behalf of TTS, endorsing the efforts of the CLTR to achieve a transparency of registry events, develop an equitable system of organ allocation, and develop an ethically proper program of deceased donation as an alternative to the use of organs from executed prisoners. TTS commends the leadership of Dr. Haibo Wang in accomplishing these objectives, which are consistent with the Declaration of Istanbul's principles and the Resolution of the 63rd World Health Assembly of 2010.
The World Health Organization (WHO) has stated clearly in its Revised Guiding Principles that "donation and transplantation activities, as well as their clinical results, must be transparent and open to scrutiny, while ensuring that the personal anonymity and privacy of donors and recipients are always protected." The CLTR has an opportunity to make data transparent by an annual release of information, revealing a reduction in the practice of liver transplantation from executed prisoners. TTS supports this annual report of data from the CLTR, maintaining its position expressed in the following policy statement:
The need for transparency and for assembling comprehensive demographic data on the international practice of transplantation dictates that these data should be accepted. The source of the organ or tissue should be clearly identified and recorded as procured from an executed prisoner. Such data should not be incorporated in the total analysis of outcomes of transplantation or other scientific registry studies.
Allocation of organs:
Drs. Haibo Wang and Sheung Tat Fan have developed an objective ranking index of medical criteria for organ allocation in China to include disease severity, donor recipient age matching, blood type and HLA matching, and waiting time of the candidate. To encourage organ donation, ranking priority is also granted to those who are living donors or any of the immediate family members of a deceased donor. This direction fulfills international standards set forth by the World Health Organization that "the allocation of organs, cells and tissues should be guided by clinical criteria and ethical norms, and not financial or other considerations. Allocation rules, defined by appropriately constituted committees, should be equitable, externally justified, and transparent." The WHO has also suggested that there be Ministerial and public oversight of updated comprehensive reports regarding the system of organ allocation in order to verify equitability and transparency.
The proposed geographic distribution of organs within China is initially to the transplant center within the organ procurement organization, then to other regional transplant centers within the Province, and then finally to a national list.
New protocol for deceased donation:
The CLTR has been a leader in the development of a new program of deceased donation noteworthy for its ethical propriety and consistent with international standards. It entails the determination of death by neurologic criteria. Even though brain death is not yet legally recognized in China, the plan is to facilitate organ donation when brain death is recognized in the intensive care units. Futile support will be withdrawn from such patients after consultation with the family who derives consent for organ donation. Minister Jie-Fu Huang has termed this program "deceased donation with China characteristics." TTS endorses the implementation of this program throughout China as the alternative to the use of organs from executed prisoners.
The June issue of Nature Reviews Nephrology includes a detailed review (Published online: 20 March 2012 | doi:10.1038/nrneph.2012.59) of major international developments since the initial meeting of the Declaration of Istanbul on Organ Trafficking and Transplant Tourism in April 2008. As this review describes, there has been substantive positive change in the organ transplant environment of several of the countries designated by the WHO as "hotspots" of trafficking and tourism.
Despite these encouraging developments, intractable problems remain. The Custodian Group (DICG) of the Declaration met most recently at the ISODP meeting in Buenos Aires to formulate future plans to be addressed through the activities of its Task Forces and in cooperation with the multiple professional societies and governmental agencies that have endorsed the Declaration. The Declaration has been used as a resource on several occasions by governmental agencies dealing with cases of tourism and trafficking. For the first time, it has become part of national transplant legislation in the new Brazilian transplant law.
At the Berlin TTS meeting, a special Declaration of Istanbul Public Session on Monday, July 16th from 7:00-8:15am in Hall 6 of the ICC Convention Center will be devoted to the Declaration and DICG members will update attendees on developments in key countries that have been both "importers" and "exporters" of transplant tourists. Plans are also underway for a fifth anniversary meeting of the Declaration of Istanbul in 2013.
To keep updated on the activities of the DICG, please visit the TTS booth at the Congress in Berlin as well as the Declaration's website: www.declarationofistanbul.org. Feel free to approach the website editors, Vivek Jha and Gabriel Danovitch with any material that may be relevant to the site. You may contact them at dicg@tts.org.
Announcing the 2014 World Transplant Congress
Save the Dates: July 26-31, 2014!
In 2006, the largest international conference in the field of organ transplantation was held in Boston, Massachusetts, designated as The World Transplant Congress (WTC). This historic meeting was the result of collaboration among The Transplantation Society, the American Society of Transplant Surgeons, and the American Society of Transplantation. Attendance reached a record high of over 6,500 participants as well as an additional 1,000 exhibit personnel.
The success of the 2006 WTC has propelled the three societies to join together again in developing another special event—they have selected San Francisco, California as the venue for the next WTC. The 2014 WTC is anticipated to be the largest and most comprehensive meeting of its kind.
As a venue, San Francisco is one of the top tourist destinations in the world, renowned for its cool summer temperatures, steep rolling hills, and eclectic mix of architecture, as well as its famous landmarks, including the Golden Gate Bridge, cable cars, and Chinatown. The city is also a principal banking and finance center, and home to more than thirty international financial institutions, helping San Francisco rank as one of the world's top producing cities and global financial centers. In addition to the many landmarks and well-known heights and sights, be sure to make time for the city's maritime heart—its waterfront, much of which has been refurbished.
When planning your attendance at the 2014 WTC, consider adding time to do a pre- or post-excursion to San Francisco's famous wine country, Sonoma or Napa valley. There will be information available regarding tours as the meeting gets closer.
The Program Committee, chaired by Barbara Murphy, will offer a wide range of learning opportunities, including basic science and clinical symposia. A record number of presentations is anticipated for 2014 WTC, recalling that the 2006 WTC received over four thousand abstract submissions.
Again, please save the dates and plan to attend the World Transplant Congress on July 26-31, 2014, and be a part of transplant history.
TTS Antibody Consensus Meeting on Testing of HLA-antibodies in Clinical Transplantation
Participants of the Working Groups met in Rome in May 2012
The detection and relevance of HLA antibodies in clinical transplantation was the topic of a meeting held in Rome on May 3-4, 2012. Sponsored by TTS and organized under the leadership of TTS President Gerhard Opelz, together with co-chairs Elaine Reed (Los Angeles) and Frans Claas (Leiden), experts from around the world met for discussion of this highly controversial topic. There were three working groups devoted to technology (chaired by Brian Tait, Melbourne, and Andrea Zachary, Baltimore), pre-transplant testing (chaired by Caner Süsal, Heidelberg) and post-transplant testing (chaired by Peter Nickerson, Winnipeg, and Howard Gebel, Atlanta). Members were: Robert Bray (Atlanta), Patricia Campbell (Edmonton) Jeremy Chapman (Sydney), Toby Coates (Adelaide), Robert Colvin (Boston), Emanuele Cozzi (Padova), Ilias Doxiadis (Leiden), Susan Fuggle (Oxford), John Gill (Vancouver), Denis Glotz (Paris), Suchitra Holgersson (Göteborg), Nils Lachmann (Berlin), Thalachallour Mohanakumar (St. Louis), Nicole Suciu-Foca (New York), Kazunari Tanabe (Tokyo), Craig Taylor (Cambridge), Dolly Tyan (Stanford), and Adriana Zeevi (Pittsburgh).
Preparations for the meeting via telephone conferences and email exchanges had been ongoing for six months prior to the meeting, such that the arguments and opinions were well-known to all when the group convened in Rome for this final conference. The meeting turned out to be exceptionally productive. Although there were differences in approaches to clinical testing, particularly between the United States and Europe, sound reasoning prevailed throughout the two-day deliberations.
Rounding off the program, issues such as non-HLA antibodies as well as testing for non-renal organ transplants were discussed. While it was impossible to obtain complete uniformity for test recommendations worldwide, acceptable approaches for suitable testing methodology, pre- and post-transplant testing schedules, and the interpretation of results were identified and agreed upon. Guidelines for antibody testing in clinical organ transplantations are currently being finalized for publication. All participants agreed that the consensus conference was timely and most useful and they greatly appreciated the support provided by TTS, which made this entire project possible. Additional travel support was provided by the Canadian Red Cross, the European Federation for Immunogenetics (EFI), the British Society for Histocompatibility and Immunogenetics (BSHI), and the German Society for Immunogenetics (DGI).
The XIII International Small Bowel Transplant Symposium, chaired by Professor Peter Friend, will be held in Oxford, UK from June 26-29, 2013. The organizing and scientific committees are currently in the process of finalizing the scientific and social programs. State-of-the-art lectures and debates with roundtable discussions will be the theme of the scientific program. With Oxford's rich cultural history, the social program will be full of exciting tours exploring the different historic and scenic views of the city. For symposium updates, please visit www.isbts2013.org.
Dr. Kareem Abu-Elmagd, current President of ITA, along with the ITA Council, is in the process of updating the association's current by-laws to allow Allied Health members to be full voting members with other well-deserved privileges.
In addition, the Association, along with the UNOS liver-intestinal committee, was able to change the current organ allocation policy in the United States to better serve short bowel syndrome patients with intestinal and liver failure. With the new policy, the candidates who have a MELD score of 29 or higher will have access to the national donor pool, which will hopefully reduce the observed high mortality rate of wait-listed patients.
In current scientific activity news, the 2011 ITR report that was presented at the XII International Small Bowel Transplant Symposium in Washington, DC is currently being published. With the primary authorship of Dr. David Grant, the report declared significant increase in intestinal transplant activities on most continents, with improved early patient and graft survival.
Transplantomics 2012: La Jolla Conference Report
The third "Transplantomics" meeting on functional genomics, genetics, proteomics, microbiomics and biomarker discoveries in transplantation.
Jeremy Chapman, TTS Immediate Past President
and Daniel R. Salomon, Chair
Held in La Jolla, California on March 8-10, 2012 and hosted by TTS and Program Chair Daniel Salomon of The Scripps Research Institute, the Transplantomics conference opened with the challenges confronting transplantation that "omics" may resolve: better understanding of the mechanisms of chronic graft loss, and minimally invasive biomarkers to personalize immunosuppressive therapy and predicted outcomes. Five "state of the art" lectures covered biopsy expression profiling (Philip Halloran), peripheral blood gene expression for acute rejection in kidney and heart transplantation (Bruce McManus), quantitative PCR profiling of urine in kidney transplants (Manikkam Suthanthiran), profiling tolerance in liver and kidney transplants (Alberto Sanchez-Fueyo) and advancing our understanding of chronic allograft injury (Mark Stegall).
The second day provided sessions on genetics, proteomics, epigenetics and microbiomics, and finally, molecular HLA typing and metabolomics. The complexities of genome-wide association studies (GWAS) to correlate individual single-nucleotide polymorphism (SNP) variations to chronic kidney transplant rejection were apparent and despite several thousand patient samples it is clear that GWAS will be valuable, but may not provide the level of genetic insight originally anticipated. Pharmacogenetics and exome-wide sequencing of patients with chronic rejection were considered. Exome sequencing provides single base detail for the protein coding sequences of the entire human genome in each individual—it was interesting to hear whole genome sequencing including the other 99% of the human genome whose function is not entirely clear.
A fascinating paired discussion of the cutting edges of the Proteome field was held that involved either starting with peptides (bottom-up) or proteins (top-down) and in the end constructing complementary pictures of proteins and the critical modifications that determine functions. The Human Proteome Project was described as designed to determine the proteomics of every known human gene. Finally, a novel approach to quantitative proteomics using multi-parameter flow cytometry was described, allowing a whole new approach to clinical diagnostics for transplant rejection and immunosuppression monitoring.
Dan Salomon described strategies developed to profile the immune-epigenomics of naïve and memory T cells at the level of methylating individual CpG sequences in gene promoter regions, while John Iacomini reviewed the master regulatory functions of small noncoding RNAs (microRNAs), emphasizing how epigenetics modifies the flow of information from the fixed sequences of genomic DNA, adding a complex layer of cell regulation. Microbiomics opened a discussion of the way microbes are synergistically associated with human beings and involved in health and disease beyond antibiotic associated diarrhea.
Henry Erlich reviewed an entirely new layer of genetic complexity revealed by molecular HLA typing using deep DNA sequencing. Metabolomics of plasma and urine were presented as methods to develop diagnostic signatures for transplant rejection, tissue injury and function and the Human Metabolome Project was highlighted—the "GenBank of metabolomics." Bioinformatics approaches were elucidated for network mapping using Cytoscape and for making sense of DNA sequencing at the whole exome and whole genome levels. Latest advances in high resolution digital imaging of biopsy histology to create objective and quantitative metrics for transplant pathology showed how we may expect to read and interpret histology in the future.
Allan Kirk described how the immune response evolves from childhood to old age and related this to the challenges of immune-senescence in transplantation. Dan Salomon proposed an integrated view of inflammation as a central driving mechanism of health and disease. We concluded by trying to understand the "value proposition" of diagnostic and predictive biomarkers for clinical transplantation—the next generation of clinical studies of biomarkers and drug therapies must integrate the new discipline of patient-centered, outcomes-based research before we may anticipate persuading anyone to pay.
The 4th International Transplantomics Conference will be held in Cambridge, England in April 2013. Put it in your diary now! Change in our field will be driven by the evolution and application of new technologies—we are just at the beginning.
4th International Conference on
Transplantomics and Biomarkers in
Organ Transplantation
Cambridge, UK | April 4-7, 2013
www.tts-transplantomics.org
Sharon Hunt, Stanford University Medical School;
Lori West, ISHLT President; and Sandi See Tai, Pfizer
A Women in Transplantation networking event was held in Prague on April 19, 2012 at the 32nd annual scientific meeting of the International Society of Heart and Lung Transplantation (ISHLT). ISHLT President Dr. Lori West introduced invited speaker Dr. Sharon Hunt, Professor of Medicine at Stanford University Medical School and recipient of the 2012 ISHLT Lifetime Achievement Award. Dr. Hunt gave a presentation on her remarkable career, which covered an unparalleled period of advancement in heart transplantation at Stanford University. Especially interesting and enlightening were her reminiscences of women in medicine in the 1970s. She was a member of the first group of women admitted to medical training at Stanford University Medical School, and her talk included photographic evidence of her time there, mini-skirts and all! Dr. Hunt is widely known for her inspirational mentorship of clinical trainees, especially women, in heart failure and transplantation, so her address at the WIT event was particularly fitting. Over 70 attendees from all levels of training and career stages had the opportunity not only to listen to a moving talk from Dr. Hunt but also to develop and renew important networking contacts. As with previous events by the hugely successful WIT initiative, the atmosphere was friendly and relaxed, and provided an encouragingly welcoming atmosphere for young women and new members. We are again thankful to Pfizer for their continuing support of the WIT initiative.
Berlin Congress WIT Events:
Monday, July 16th
WIT Networking Event (lunch) • Noon-13:30 • ICC Berlin (Oslo Room)
Elmi Muller Do You Treat Rottweilers or Poodles?
Sunrise Symposia • 07:00-08:15 • ICC Berlin (Hall 6)
Regine Papp-Engels, Germany A perspective on Female Medical Professionals in the Developed World
Delawir Kahn, South Africa Feminizaton in Medicine as a General Trend and the Implications for the Workplace
Beatriz Dominguez-Gil, Spain Perspective of a Female Professional: Important Factors in Becoming a Female Professional
Concurrent Oral Presentations • 15:30-17:00 • ICC Berlin (Hall 6)
Sabine Wohlke, Germany Gender Differences in Living Organ Recipients' Conceptions of the Body—
Medical Anthropological and Ethical Perspectives
Sven Pischke, Germany Outcome of Pregnancies after Liver or Kidney Transplantation
Mitra Mahdavi-Mazdeh, Iran Share of Females in Nephrology of Iran
Hagai Boaz, Israel The Gender Gap in Israeli Living Kidney Donations
Maren Schulze, Germany Training Female Transplant Surgeons in Germany—
Mandatory Changes Due to Gender Distribution of Medical Students—
How Will the System Cope?
Chi-Chua Yeh, Republic of China Female Transplant Surgeons in Taiwan
Charlotte Hauser, Germany Outcome after Allogenic Kidney Transplantation Distributed by Gender of the Surgeon—
A Retrospective Single Centre Analysis
Heba Abdelrazik, Egypt The Egyptian Revolution and Its Impact on An Egyptian Female Doctor Living Abroad for Seven Years
Sommer Gentry, USA Sommer Gentry, USA
We are pleased to announce that the 12th International Xenotransplantation Association Congress (IXA 2013 Osaka) will be held on November 10-13, 2013 at the Osaka International Convention Center in Osaka, Japan. We have co-organized a special Clinical/Basic symposium on ABO incompatible/hyper-immune transplantation. This joint forum will be of special interest for transplant surgeons, physicians and scientists and will promote discussion of strategies for addressing antibody-mediated rejection and organ shortages: the two major obstacles in clinical transplantation. More specifically, the hot topics in the program will include:
• How can we overcome immunoresponses associated with presensitization?
• Update on preclinical organ and cell xenotransplantation
• Are we ready for clinical islet xenotransplantation?
• Advanced genetic engineering
• Zoonosis
In addition, we will also discuss potential uses of "Xeno" and "Regenerative" technologies to resolve the organ shortage.
Osaka is the capital city of the western province of Japan, located an hour's drive from the traditional old cities of Kyoto & Nara. We look forward to meeting and welcoming the international delegates to this thriving urban city surrounded by beautiful historic sites.
The Council of the International Pancreas and Islet Transplant Association (IPITA) continues to work hard to implement the various suggestions outlined at our Council retreat last summer. Our overall aim is to ensure that IPITA's activities include more than just the Biannual Congress, and that we truly represent the whole pancreas and islet transplant community worldwide. Membership numbers have increased over recent months, and we continue to look at new initiatives that ensure that IPITA membership offers real value for those who join. Our Congresses do remain a major priority, and Peter Stock is making excellent progress with preparations for the 2013 IPITA Congress, which is being held in Monterey, California from September 24-27, 2013 (for further information please visit www.ipita2013.org).
We are pleased to announce that the 2015 Congress will be a joint meeting between IPITA, the International Xenotransplantation Association (IXA), and the Cell Transplant Society (CTS). After consultation with the Councils and memberships of the three Sections, Melbourne, Australia has been selected as the venue for this landmark meeting. In the meantime, we look forward to catching up with IPITA members at the TTS Congress in Berlin, and always welcome constructive suggestions about new initiatives that can make our organization stronger. Please don't hesitate to contact IPITA President Paul Johnson at Paul.Johnson@nds.ox.ac.uk
Cell Transplant Society members:
It is an in-between year for us in the Cell Transplant Society (CTS)—we remember the great success of the 2011 meeting in Miami and look forward to seeing all of the CTS members at the 2013 meeting in Milan. We have not yet established the program for the Milan meeting, so suggestions are welcome. They can be sent to meetings@tts.org or directly to Stephen Strom at stephen.strom@ki.se.
We hope to build on our history at CTS of timely and informative sessions at this meeting, so member input is not only welcome but expected. Thank you for supporting this year's TTS meeting in Berlin and see you all next year in Milan. Don't miss visiting Da Vinci's famous painting of the Last Supper at the monastery of Santa Maria delle Grazie during your time in Milan—you should book well in advance.
da Vinci's The Last Supper
IHCTAS Calling
It is a great pleasure to invite you to the XI Meeting of the International Hand and Composite Tissue Allotransplantation Society (IHCTAS) from August 29-31, 2013 in Wroclaw, Poland. Following the successful meeting in Atlanta, we would like to welcome you to the largest city in Poland, situated on the Odra River. Wroclaw has been known as a center for culture and academia for many centuries and was selected as a European Capital of Culture for 2016. During its more than one thousand years of history, Wroclaw has been part of either Poland, Bohemia, Austria, Prussia, or Germany, which has greatly influenced the varied architecture and culture of this capital of Lower Silesia.
The XI Meeting is designed for physicians, surgeons, nurses, organ procurement specialists, scientists and trainees who are interested in Composite Tissue Allotransplantation (a.k.a. Vascularized Composite Allotransplantation (VCA)). The meeting will include plenary sessions, workshops and abstract presentations, providing an overview of current developments and new perspectives. The program is developed to encourage the exchange of novel scientific and clinical information and support the interchange of issues surrounding VCA. For more information, please visit our website at www.ihctas2013.pl
We look forward to seeing you in Poland in 2013!
Transplant Infectious Disease Update
TID 6th International Conference
Camille N. Kotton
The Transplant Infectious Disease (TID) section of The Transplantation Society (TTS) will hold its 6th International Transplant Infectious Disease Conference, in Berlin, Germany, on July 15, 2012, just before the start of the TTS meeting. We have an exciting array of speakers from all over the world, all experts in their field, discussing cutting-edge topics in transplant infectious disease. The meeting will be highly clinically based, with transplant clinicians attending from varied backgrounds. For those of you who must miss the meeting and who are TTS/TID members, many of the session recordings will be available online at www.tts.org following the event.
In addition, the Transplant Infectious Disease section has been busy working on guidelines involving donors and tuberculosis risk, which should be published soon. We have also been working together with surgical colleagues to develop guidelines on the management of infectious disease issues in composite tissue transplantation (hand, face, limb). Based on the popularity of the initial international guidelines on CMV management, we are planning a second meeting to be held this fall. Anyone with additional ideas regarding projects for the Transplant Infectious Disease section is welcome to contact the president, Dr. Camille Kotton, directly at ckotton@partners.org.
We warmly welcome all transplant clinicians who wish to become members of the Transplant Infectious Disease section. For further information on membership, please contact TID's representative at TTS, Alexandra Murphy, at membership@tts.org / 514-874-1717.
session recordings from the TID International Conference
will be available for TTS/TID members at www.tts.org
The New ISODP Board and Council Deliberate on Strategic Plan and Events
The ISODP's leadership continues to discuss implementation strategies for the association's strategic plan developed to focus and promote its aims and objectives. The main areas of engagement include:
Increase donation internationally by establishing a process to engage in continuous improvement in donation and plan congresses and meetings to increase donation globally;
Enhance available resources to improve donation practices by using shared information and creating meaningful associations; and,
Establish an integrated network of donation professionals to align with other organizations and associations and enhance the ISODP membership.
Günter Kirste and Kimberly Young deserve special recognition for formulating the strategic plan.
In 2010, the ISODP and TTS, with the collaboration of Astellas, launched the Transplant Coordinators Scholarships in order to enhance international training opportunities. Several scholarships have been awarded and a second round of reviews are in the final stages and will be announced at the TTS Congress in Berlin.
The Australian DonateLife Network and The Transplantation Society of Australia and New Zealand (TSANZ) look forward to hosting everyone in Sydney on November 21-24, 2013 for the 12th Congress of the International Society of Organ Donation and Procurement. ISODP wishes Dr. Jeremy Chapman and his team success in the planning and execution of this congress.


>> In the wake of hurricane Matthew life threatening floods. At least two dozens dead in the US. 18 in North Carolina alone.>> In two years, I've never seen it like this.>> The town of Lumberton along the Lumber river among the hardest hit areas. Reuters photographer Carlo Alegria is there.
>> The entire town of Lumberton has been inundated. I would say at least 90% of the businesses are under water and most of the houses also that I've witnessed driving around are completely under water as well. It was a very eerie feeling last night. I was sleeping in the town in my rental vehicle, because I wanted to maintain my position behind police lines.
And with all the lights off and no one in the town, it was really quite eerie. The people have been evacuated to a couple of different UNKNOWN] shelters in conjunction with the Red Cross.>> Nearly 4,000 people taking refuge in North Carolina shelters. Expedited Federal aid approved for 31 counties.
>> This is gonna be a prolonged hurricane for us, even though the skies are blue.>> Throughout the southeast, more than half a million people still without power Tuesday night. Destroyed homes and impassable roads from Florida to Virginia with some waterways still rising. And in Haiti, the death toll now at least 1,000.
Relief finally arriving earlier this week, with the UN Secretary General saying some towns and villages have been, quote, wiped off the map.


An old video of now-Rep. Alexandria Ocasio-Cortez playfully recreating a dance scene from "The Breakfast Club" was resurfaced anonymously on Twitter last week — resulting in a slew of misleading stories claiming conservatives were outraged over it, despite virtually no supporting evidence.
The 2010 footage of Ocasio-Cortez dancing comes from her days at Boston University. It went viral, for sure. But The New York Times, GQ, Newsweek and Ocasio-Cortez, among others, were quick to falsely claim that conservatives were somehow upset by the harmless video.
"It caused a social media stir, with the mainstream media and liberals lining up to cheer it and condemn conservatives for being offended by it. The only problem: Conservatives were not actually offended by it," Media Research Center's Clay Waters wrote.
The Times published a story headlined, "Alexandria Ocasio-Cortez Dancing Video Was Meant as a Smear, but It Backfired." It doesn't feature a single example of anyone being offended with the exception of an anonymous Twitter account that first drew attention to the video saying it showed "America's favorite commie know-it-all acting like the clueless nitwit she is." However, the Times managed to find examples of Ocasio-Cortez supporters condemning conservatives for being critical of the video.
Conservative strategist Chris Barron told Fox News that the mainstream media is "so desperate to make conservatives look bad that they will invent a controversy when there isn't one," with the Ocasio-Cortez video the latest example.
Perhaps the most overblown example was published by Newsweek, which wrote that "Conservatives mock Alexandria Ocasio-Cortez for college dancing video, everyone else thinks it's adorable," while not citing any "conservatives" beyond the original anonymous Twitter account. Media watchdogs pounced on Newsweek for the misleading headline.
NowThis likewise posted a video claiming conservatives tried to "shame" Ocasio-Cortez with the clip, but mostly cited tweets praising her cool dance moves — with not much in the way of criticism beyond the original anonymous tweet.
The social media-savvy Ocasio-Cortez used the viral video as an opportunity to knock political rivals, tweeting "I hear the GOP thinks women dancing are scandalous," with footage of her dancing in the halls of Congress. While Ocasio-Cortez didn't provide examples of Republicans claiming dancing is "scandalous," her new video has been viewed nearly 20 million times.


Accenture identifies seven major technology trends that are transforming the business landscape.
Accenture is advising clients that they need to become a lot more proactive about IT in the months and years ahead in order to stay ahead of competitors or risk being consigned to the scrap heap of history.
While keeping pace with emerging technologies in the enterprise has always been important, Accenture CTO Paul Daugherty says a convergence of major technology trends is essentially creating a primordial soup of technologies that, once met with the right catalyst, will transform business as we know it.
"Every business is going to become a digital business," says Daugherty. "Organizations today need to start thinking in terms of building architectures capable of addressing the needs of a truly digital business."
Mobile computing, social networks and context-based services have increased connections with consumers, but many companies have lost customer intimacy in the process. These connections are being viewed as another communication or transactional channel rather than as opportunities to improve customer relationships.
Most of today's enterprise software applications are designed for a specific function and capture only the data needed to complete that function. Organizations that use existing data as an input to make strategic decisions often find that information gaps arise because important questions weren't formulated when the applications were being designed. As a result, the relevant data isn't captured. What's needed is a strategy that sees data more as a supply chain than a warehouse. Companies that recognize this and make data a strategic asset that drives business outcomes will possess an advantage over those that view data merely as an output.
In addition to data variety and volume, companies now need to consider the third "V" of data: velocity. A surge of new technologies, including high-speed data storage, in-memory computing, analytics advances, data visualization and streaming data querying, is accelerating the entire data cycle from insight to action and improving the enterprise's ability to deal with greater data velocity.
Social technologies has profoundly changed the way users communicate with one another. By embedding similar collaborative tools into their business processes, enterprises can take advantage of employees' growing comfort with social networks to gain a new level of productivity.
Software-defined networking, in which the network is managed through software instead of hardware, provides a giant leap forward in enterprise flexibility. Organizations can now reconfigure the connectivity of systems without changing the physical characteristics, making it easier for businesses to manage change, integrate cloud services and get more return from their network investments.
Despite recent advances in security technology, safeguarding the digital business remains a challenge. The entry points for an attack are constantly expanding. Optimal IT security needs to go further than prevention. IT's core challenge is to not only stay current with the latest in security, but to get smarter about understanding and engaging the enemy and being able to adapt the enterprise's defenses to match the threat. Security architectures need to remain flexible and incorporate "active" defenses.
Technologies underpinning cloud computing are pervasive and here to stay. The benefits are numerous: helping companies differentiate their business, get their products and services to market faster, enhance operational efficiency, and respond more quickly to new opportunities and challenges. Many organizations are already embedding cloud computing with their legacy systems and traditional software to create hybrid environments. This requires a clear understanding of, and approach to, the skills, architecture, governance and security required, whether it's the applications, platforms or IT infrastructure that's in the cloud.


text:
The politics sketch
May has kicked her Brexit can firmly into Corbyn's face
John Crace
Sick of seeing the Tory party tearing itself apart, May is now getting Labour in on the act
@JohnJCrace
Tue 2 Apr 2019 15.48 EDT Last modified on Tue 2 Apr 2019 17.39 EDT
The only real conclusion her near-obsolete binary brain had reached was that Brexit was a complete mess. Photograph: Jack Taylor/AFP/Getty Images
Almost three years into the Brexit process and trust levels are near zero. After a seven-hour meeting, the cabinet had been frisked for their phones – Oi Gove, I want your burner as well – and kettled inside No 10 to prevent them from blabbing. This was one statement that Theresa May would get to make that the country hadn't already heard from someone else.
Timed to coincide with the six o'clock news, the Leader in Name Only walked nervously towards the Downing Street lectern. Understandably, as the last televised speech she had given from there had pretty much alienated every MP, along with the entire country. This time she kept it short and sweet. A crisp three minutes. But true to form, even at that length no one was entirely sure just what she had said. Or what it meant. Or if it was even possible.
May to ask for short Brexit extension and reaches out to Labour
Lino began by all but ruling out a no-deal Brexit. Though leaving the back door open just a smidgeon to one. She was fed up with bashing her head against the DUP and the Spartans of the European Research Group, so now she was going to try her luck with Jeremy Corbyn. Having kicked the can down the road for months on end in a desperate effort to keep her party together, she was now kicking it firmly into the Labour leader's face. There was one question Jezza had to ask himself: "Do I feel lucky? Well, do ya punk?"
What she hadn't said was what compromises she was prepared to make. Mainly because she simply didn't have a clue. You don't get to resolve a lifetime of indecision in one cathartic, blinding moment of clarity. A Maybot is, as a Maybot does. The only real conclusion her near-obsolete binary brain had reached was that Brexit was a complete mess and, if at all possible, she didn't want to go down in history as the prime minister who had deliberately chosen to tip the UK into recession and civil unrest.
Mostly she was just fed up, though. If the entire country was stressed out by Brexit, how did they think she was feeling? Just imagine what it must be like to be the person in charge who didn't have a clue. She had felt so alone. Especially with a cabinet full of idiots. So it was time to let someone else have a go. And why not Corbyn? He'd been going on enough about how he had all the answers, so let him put up or shut up.
Theresa May calls for short extension to article 50 – video
May was also sick and tired of the Tory party tearing itself apart. Hell, there was fuck all left of it to fight over now anyway. Most of her MPs and cabinet were barely on speaking terms with each other now. Some of them were barely even on speaking terms with themselves, they had changed positions so often. They were an anarchic rabble. She might be Lino but the Conservatives were a Party in Name Only. She'd be gone soon and there would be nothing left for her successor to lead. With any luck. Pick the bones out of that, Boris.
So why not have some fun in her last few days and see if she could get the Labour party to tear itself apart as well? Let Corbyn feel the heat for a change. Was he going to insist on a second referendum or would he settle just for a customs union and single market? Were Labour basically a party of remain or leave?
May's desperate pitch for cross-party unity is a leap into the dark | Rafael Behr
Either way, it was no skin off her nose. If the cross-party talks fell apart – as they probably would – and the decision came down to a series of binding indicative votes with her deal as one of the options, she could live with that. All that really mattered was that she shouldn't get the blame. The one thing she had learned from getting up close and personal to a shitshow, was that it was always better to have as many people as possible with their arms, elbow-deep, bathed in shit. After all, it wasn't as if there wasn't more than enough of the stuff to go round. The Grand Wizard of Mogg and Mark Francois made sure of that.
As she walked off camera, Lino breathed a sigh of relief. Things would unravel. Of course they would. Even if Labour did play ball, something would go wrong with the extension or the European elections. That was the whole point of Brexit. Things fall apart. The centre cannot not hold. There was literally nothing on which enough people could agree. But she had come out of the day alive and had bought herself the best part of a week. And given how the day had started, that was cause in itself for celebration.


Having been awarded the overall "Best Floral Display" for his "Wonderful Wizard of Oz" themed design for Belgravia In Bloom along with two "Highly Commended" awards and a Gold, Neill tells us about his fabulous week in Belgravia and Chelsea during the RHS Chelsea Flower Show.
Every year, during the RHS Chelsea Flower Show, Neill focuses on a single flower type and creates an exceptional showcase at his Belgravia boutique for all to enjoy. This year, it is the Hydrangea that takes centre stage. Neill will host HELLO HYDRANGEA! - a definitive look at the new star of the flower world with an impressive display of rare and new varieties of Hydrangeas. In this May blog post he shares his research and sourcing in Holland for the fabulous blooms. HELLO HYDRANGEA! is a Chelsea Fringe event.


text:
Home / Ephesus Highlihts / State Agora
State Agora
Like the Bath of Varius, the State Agora was renovated multiple times during its history. The first agora on this site was built in the 6th century B.C. in Hellenistic style. During excavation that agora was found buried approximately 2 meters below the present Agora. The current structure would have been built in the Roman Period in the first century B.C. along with a square temple. The temple was demolished during the reign of Augustus and never rebuilt because of its connections with Egypt. The Agora was reconstructed in the 3rd century during the reign of Caracalla (211-217 A.D.) The final renovations were done by Emperor Theodusius (between 379-395 A.D.)
This agora would have been used as a public area and a meeting place for governmental discussions. Thee sides were bordered by Stoas, an architectural structure that would provide shelter from intense sun or rain. A water reservoir at the corner of the Agora would have been supplied by the Pollio Aqueduct, the remains of which can still be seen 5 kilometers away. In the very center of the Agora was a temple dedicated to the Egyptian goddess Isis that would have served as the chamber where all decision would have been voted on. The pink granite columns still remain of the temple, proving a relationship once existed between Egypt and Ephesus since there are no pink granite quarries in Anatolia.
Excavations around the State Agora unearthed a large number of graves dating back to the 6th-7th centuries BC and an archaic terracotta sarcophagus. Near the area, about 3m below the surface, they also discovered a road surrounding the Panayir Mountain. This has lead archaeologists to believe the northeast side of the State Agora must have been used as the Necropolis of Ephesus during the archaic period. One of these tombs is currently on display in the Ephesus museum.


text:
Q: run windows application at client side from aspx.cs I have windows application in c#.that is installed for client . I need run that window application from client side when user button click in asp.net web application
Explanation
I have task that scan hard copy from scanner . I developed web application in asp.net c#. I have search in Google to do this so many peoples are saying that is not possible due to permissions. so I developed windows application when I run that window application(c#) it scan the hard copy from scanner this window application run in background so I need to run this window application. when user button click in asp.net web application

A: You cannot run applications from a website on client's machine due to security & permissions.
However, your website probably can communicate with the scanner. Check this detailed answer.

A: While you cannot run the application from the browser, there is another option, if your application is already running in the background. Then you can make it listen to some local port and then ask the browser to redirect to the URL (consisting of localhost and that port, e.g. http://localhost:34554), so the application would receive an HTTP request and will know it needs to become active / show its window / etc. Using this technique, you could even pass some parameters to your application using query params in the URL.
Another option that allows you kinda run an application from the browser is Microsoft ClickOnce - it is just a simplified way of installing and running an application without the need for the user to download and manually run the installer.

redpajama_set_name: RedPajamaStackExchange


1. We are ahead of the curve for creating a FB game app to promote a brand. Hasn't been done so far that I've seen. I even asked the FB guy who was the Tues. keynote and he couldn't think of any. This fact makes me very excited and a bit nervous.
2. We need to plan for server load. We cannot predict how much traffic will hit the server, and we need to come up with a plan should it blow up.
3. We've come up with another game title idea and JK has about 30 paper-based game titles that his dad created that already create revenue. We could be busy for a while.
4. I need reliable Flash developers who know what they are doing. Not to say that Mike isn't doing a great job, but I need more help.
5. My client should exploit the hell out of the fact that this is pretty innovative for them to have a FB game app. They need to be ready to advertise.
6. Social game companies totally copy off of each other and they don't seem to care.
7. The gaming industry has been dragging their feet. At the first GDC I attended back in 2007, I felt like a total outsider. When I told people I met that I work with Flash, they looked at me like I was nuts. Now all of these social games are Flash-based. I actually attended a session on what game developers (for traditional platforms) can learn from Flash portal games today. Really?? These games have been around FOREVER!
8. I feel very confident that the 3 social game ideas we have can be built and used for social media. Two of them would be geared toward males (more mature content), while the third would be directed more toward females.
9. EA acquired Playfish. In 2007 I hung out with those guys from Playfish because they were doing Flash. They were really small… cool people… doing portal games. EA acquiring them is a huge deal.
10. Facebook dominating social media is not going away anytime soon – until someone comes out with something better. Myspace just isn't in the big mix. I'm not even sure where hi5 fits in.
I'll be back to my user reviews of Cafe World, Mafia Wars, and the newest one I am playing, Social City. I will also have an update on Farmville.
I CANNOT wait for our game to launch!!!!
PS – Dear Facebook – please bring back Newsfeeds just for games. It makes things a lot more tolerable to have all of the Farmville feeds in one place, all of the Cafe World feeds in another, etc.