Feed a Cell, Deprive an Organism?
Abstract: Throwing a wrench into the pathway that turns food into energy sounds like a bad idea, but it might lengthen life. Flies survive nearly twice as long as normal when they don't make enough of a protein called INDY, and new work shows that INDY shuttles organic molecules required for metabolism across the cell membrane. The protein's apparent role in energy production suggests a connection with a well-known life-extension method--calorie restriction--and the findings might help reveal how the long-lived flies persevere.
Two years ago, Stephen Helfand of the University of Connecticut Health Center in Farmington and colleagues found a gene in fruit flies that nearly doubles the insects' life-span. The gene, called I'm not dead yet (Indy), encodes a protein similar to members of a mammalian protein family that carry negatively charged organic molecules across the cell membrane.
To find out whether the INDY protein performs a similar function in flies, the team members engineered frog eggs--a common testing ground for protein function--to manufacture INDY, then they surrounded the eggs with radioactively tagged succinate, a molecule that's necessary to convert food into useable cellular energy. The INDY-producing eggs took up more than 50 times as much succinate as did normal eggs. Similar experiments revealed that INDY also moves other negatively charged molecules needed for metabolism, as do similar mammalian transporter proteins. Unlike the mammalian transporters, however, INDY does not piggyback its cargo with sodium ions.
Most cells maintain a low internal concentration of sodium ions. Some transporters rely on the preponderance of sodium outside the cell to propel their substrate across the membrane; the ions naturally flow into the low-sodium interior of the cells, carrying the organic molecule along with them. INDY, which apparently doesn't work this way, defines a new class of transporter.
In additional experiments, the researchers used antibodies that bind INDY to determine where in the fly the protein conducts business. They found it where it should be if it carries metabolic products: in the cell membranes of nutrient-absorbing tissues, such as the digestive tract and the fat body--the fly's version of a liver. Flies with life-extending mutations in the Indy gene had abnormally small amounts of the protein in these organs, indicating that the mutations don't generate an abnormal version of INDY but make less of it.
Discovering that INDY transports the products of metabolism "bolsters the notion that energy regulation is related to aging ... in the fly," says geneticist Marc Tatar of Brown University in Providence, Rhode Island. If INDY helps the cell turn nutrients into energy, reducing INDY quantities might lengthen life in a way similar to calorie restriction, Helfand conjectures. The work "suggests that somehow reducing energy or just nutrient flow has something to do with aging," Tatar says, "but it doesn't yet clarify how, or what the mechanism is." Understanding how Indy mutations tamper with metabolism could give researchers a tool to turn the screws on aging in mammals.


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Home » General » Exciting Education Webinars Announced for Spring 2021
Exciting Education Webinars Announced for Spring 2021
Horse Sport Ireland (HSI) is delighted to announce the first coach education webinars of 2021. The webinars cover a wide range of topics; from sport psychology to veterinary and include some incredible speakers.
We kick off the year with an intriguing event which will ensure coaches can assist their riders to achieve their set goals for the year. 'The Chimp Paradox' is a mind management programme developed by Professor Steve Peters This mind management model is used by high level athletes and coaches around the world with great success, including by Sir Chris Hoy, Ronnie O'Sullivan and Victoria Pendleton.
The workshop will provide an introduction to the Chimp Model and will provide insight into how the mind can help and hinder performance.
It will focus on exploring the practical application of the concept to your professional and sporting environments.
The event will be facilitated by Dr Anna Waters, Managing Director and Psychologist with Chimp Management. Anna works with several sporting bodies including the British Olympic Federation, British Equestrian Federation (BEF) and the Hong Kong Jockey Club (HKJC).
Bookings are open to all and the material will be especially suited to Level 2 and 3 coaches Places are limited so book early to avoid disappointment.
Later in the month sees the return of top international sport horse farrier Haydn Price. Following the success of his first webinar HSI are delighted to announced that Haydn will be returning for a series of events throughout spring 2021.
'The Hoof; Form and Function' will be delivered in two events, the first in January and the second in March 2021.
Haydn will discuss the evolutionary design of the hoof and explain how it works. The webinars are aimed towards coaches of all levels but are open to anyone who has an interest in the area.
Haydn is the consultant farrier to the Hong Kong Jockey Club Elite Performance Programme and former farrier to the Team GB Dressage and Show Jumping Teams.
In 2013, Haydn was inducted into the International Farriery Hall of Fame for his continued services, commitment and education to the International Farriery Profession. Before this, in 2011, he was awarded the British Equestrian Federation (BEF) Medal of Honour for his continued contribution to farriery.
All bookings can be made by following this link: https://www.horsesportireland.ie/hsi-coaching-courses-sign-up-form/
Introduction to the Chimp Model
Date: Monday 11th January
Cost: €30
'The Hoof; Form and Function' Part 1
Date: Tuesday 19th January
Date: Wednesday 3rd March

redpajama_set_name: RedPajamaCommonCrawl


text:
Der Begriff Fair Game bezeichnet eine 1967 vorgestellte Praxis der Scientology-Kirche, die den mitunter rigorosen Umgang mit deren internen und externen Feinden oder Kritikern beschreibt. Ein Jahr nach ihrer Vorstellung wurde die Vorgabe L. Ron Hubbards am 21. Oktober 1968 wieder zurückgenommen, wobei sich dies nur auf das Verwenden des Wortes Fair Game bezog, die Praxis an sich wird bis heute angewendet.

Für den englischen Sprachraum zählte der Foster-Report für die Jahre 1966 bis 1970 insgesamt 29 Fair-Game-Attacken gegen Kritiker oder Opponenten. Seit den 1970ern wurden vermehrt Regierungsbehörden, Behörden- und Medienvertreter sowie Einzelpersonen ins Visier genommen. Dabei wurden u. a. Scientology-Programme für die verdeckte Infiltration des Internal Revenue Service (IRS – die amerikanische Finanzbehörde) und von US-Regierungsbehörden im Rahmen der Operation Snow White umgesetzt.  Die Aktionen selbst sollen innerhalb der Scientology-Organisation vom Guardian Office (GO) und nach der Umstrukturierung in den 80er-Jahren vom Office of Special Affairs (OSA) durchgeführt worden sein.

Ende der 1980er bezeichnete die Scientology-Kirche im Rahmen einer Berufungsverhandlung im Fall Lawrence Wollersheim vs. Scientology Fair Game als einen Tätigkeitsschwerpunkt (core practice) und dass dies infolgedessen als religiöse Ausdrucksform geschützt sein sollte.

Geschichtliche Entwicklung

Nachdem L. Ron Hubbard 1950 sein Buch Dianetik: Die moderne Wissenschaft der geistigen Gesundheit veröffentlicht hatte, verkaufte er innerhalb von zwei Monaten nicht nur 55.000 Exemplare, sondern rief auch eine größere Anzahl von Rezensenten und Kritikern auf den Plan.

L. Ron Hubbard verfasste 1959 das geheime Handbuch des Rechts (Manual of Justice), das nur das Office of Special Affairs (OSA – Büro für Spezielle Angelegenheiten) und Spitzenfunktionäre von Scientology kennen: Leute greifen Scientology an: Ich vergesse das nie. Ich zahle immer mit gleicher Münze zurück, bis der Punktestand ausgeglichen ist.

Am 1. März 1965 prägte L. Ron Hubbard dann einen Begriff für das Vorgehen gegen Feinde von Scientology: Fair Game ("Freiwild"). Eine wirkliche Unterdrückerische Person oder Gruppe [habe] keinerlei Rechte, so Hubbard.

Am 18. Oktober 1967 verfasste Hubbard einen Scientology-Gesetzesbrief (Policy Letter) mit dem Titel Penalties for Lower Conditions, wo der Begriff Fair Game (Freiwild) und das entsprechende Vorgehen detailliert beschrieben wurde.

Im Gesetzesbrief vom 18. Oktober 1967 ging es um verschiedene Zustandsformen, wie sie innerhalb von Scientology Anwendung finden. Während die ersten drei Paragraphen in erster Linie für die interne Verwendung gedacht waren, ist der vierte Paragraph sowohl intern als auch extern gültig: Feind: Regel für Unterdrückerische Personen anwenden. Freiwild. Darf seines Eigentums beraubt oder (in jeder Weise durch jeden Scientologen) verletzt werden, ohne dass dies disziplinarische Folgen für den Scientologen hat. Darf hereingelegt, verklagt, belogen oder zerstört werden.

Am 21. Oktober 1968, also über ein Jahr später, wurde der Begriff Fair Game von Hubbard zurückgenommen: Die Praxis, Personen zu Freiwild zu erklären, wird eingestellt. Fair Game darf in keiner Ethik-Anordnung mehr stehen. Es schadet uns in der Öffentlichkeit. [Die neue Regel] bedeutet nicht, dass irgendwelche Maßnahmen zum Umgang mit Unterdrückerischen Personen aufgehoben werden.

Kontroverse
Die Scientology-Organisation bestreitet heute die Verwendung der Fair-Game-Praxis und weist darauf hin, dass deren Gebrauch 1968 aufgehoben worden sei.

Frank K. Flinn, ein ehemaliger Franziskaner, der am Maryville College in St. Louis lehrte, bevor er sich als Consultant in Bereich Religion und Theologie selbständig machte, sagte immer wieder als Gutachter für Scientology aus. Vor Gericht meinte Flinn, auf die Fair-Game-Praktik von Scientology angesprochen: Fast alle religiösen Bewegungen gehen anfangs hart gegen ihre Gegner vor, im Laufe der Zeit würden sie nachsichtiger.

Literatur

Einzelnachweise

Scientology

redpajama_set_name: RedPajamaWikipedia


text:
describe('Window Service', function() {
    var scope1, scope2,
        scope1Listener = {listener: function() {}},
        scope2Listener = {listener: function() {}},
        windowService;

    beforeEach(module('ks.WindowService'));

    // Get scope and register event listeners
    beforeEach(inject(['$rootScope', 'WindowService', function(rootScope, theWindowService) {
        scope1 = rootScope.$new();
        scope2 = rootScope.$new();

        windowService = theWindowService;
        scope1.$on(windowService.WINDOW_SCROLL, function() {
            scope1Listener.listener();
        });
        scope2.$on(windowService.WINDOW_SCROLL, function() {
            scope2Listener.listener();
        });
    }]));

    afterEach(function() {
        scope1.$destroy();
        scope2.$destroy();
    });

    it('is defined correctly as a module', function() {
        expect(windowService).not.toBeUndefined();
    });

    it('doesnt allow registering a non scope object', function() {
        expect(function() {
            windowService.registerForScroll({});
        }).toThrow();
    });

    it('fires WINDOW_SCROLL event on all the registered scopes on scroll', function() {
        spyOn(scope1Listener, 'listener');
        spyOn(scope2Listener, 'listener');
        windowService.registerForScroll(scope1);
        windowService.registerForScroll(scope2);

        $(window).trigger('scroll');
        expect(scope1Listener.listener).toHaveBeenCalled();
        expect(scope2Listener.listener).toHaveBeenCalled();
    });

    it('does not fire WINDOW_SCROLL event on unregistered scopes on scroll', function() {
        spyOn(scope1Listener, 'listener');
        spyOn(scope2Listener, 'listener');
        windowService.registerForScroll(scope1);
        windowService.registerForScroll(scope2);
        windowService.deregisterForScroll(scope1);

        $(window).trigger('scroll');
        expect(scope1Listener.listener).not.toHaveBeenCalled();
        expect(scope2Listener.listener).toHaveBeenCalled();
    });

    it('fires WINDOW_SCROLL event on the scope on window scroll', function() {
        spyOn(scope1Listener, 'listener');
        spyOn(scope2Listener, 'listener');
        windowService.registerForScroll(scope1);

        $(window).trigger('scroll');
        expect(scope1Listener.listener).toHaveBeenCalled();
        expect(scope2Listener.listener).not.toHaveBeenCalled();
    });

});

redpajama_set_name: RedPajamaGithub


'Specifically which mission are we talking about?' Jace asked nonchalantly.
A waiter came along and asked if they required anything else. They placed food orders and waited for him to leave.
'So anyway, Barnard's Star has four planets. It's difficult to detect the rocky ones and both Administrations wanted to settle the question. I made landing on Barnard IV. It was the nearest plant to where I exited the wormhole.
She switched off the last of the electronics to conserve energy and threw the switch to open the hydraulic doors. 'Come on Reeves, woman up. It's only a bit of wind and no worse than Scotland in November.' The door opened painfully slowly and she stepped out onto the grey soil of an alien world.
She was on a beach, the ship landed around 100 yards from the shore. The image was not one fit for postcard covers. The sand was a dull grey, the angry waves bashing the shore a dirty grey mixed with a pale grey foam. The sky was darker than the colour of snow clouds she was used to, and the rocks at the end of the beach were obsidian black – the only break from the grey of the environment.
The sand banked upwards towards the rock and from this position, she could not see a clear way up the jagged edges of the rock. It was her only way off the beach without making a swim for it and she didn't fancy swimming in that, even if it had been still.
She headed west to the end of the beach, examining the obsidian cliff face for a safe route up. As she reached the west end, she could see the rock disappearing into the mist a short distance away. Turning around, she began a slow walk east. After just a few yards, something glinting in the sand caught her eye.
Previous Spoof, Parody or Satire? And what's the Difference?!


In today's tough economic climate even industrial robots are having a hard time finding work. So it's nice to see that researchers at Chiba University in Japan have successfully taught a robot arm how to juggle. An important skill that will let robots continue to earn a living by busking on the streets.


In this comedy-drama, Pepijn and Sjors' steady, seven-year relationship is shaken up after they allow a young student named Cas to sleep on their couch until he finds a place of his own. Gradually, both men fall head over heels for Cas' laconic charm and it forces them to reconsider their many long-term plans. Is Cas' presence endangering their relationship or is he actually a blessing in disguise?


text:
2 B 1 - Ask 1
DDGM Trestle Board
District Lodges
District Grand Lodge Officers
Protocol & Etiquette
Freemasons of Niagara B District
The Grand Master and The District Deputy Grand Master welcome you
M. W. Bro. Thomas Hogeboom Grand Master – 2022-2024
R. W. Bro. David J Plyley District Deputy Grand Master 2021-2023
What do Masons do?
Why become a Mason?
Making Good Men Better.
Masonry, or Freemasonry, is the world's largest and oldest fraternal organisation. The group's members are united in their desire to see each other develop into stronger men. Its principles and body of knowledge are grounded on the idea that every man must work to better himself while still being loyal to his loved ones, his community, his country, and his fraternity.
It has been around for generations, and its members come from many walks of life (notable politicians, doctors, builders, farmers, etc.).
Possibly even you.
Historic…and up-to-date.
Our 550+ lodges in Ontario provide members with opportunities for personal growth, charitable service, and meaningful social connections, all of which are grounded in our shared commitment to three fundamental principles: brotherly love, charity, and truth.
Benefits … for both you and the world.
Freemasonry provides its members with numerous benefits, including the possibility of personal development, the possibility of social improvement, and the means by which to leave the world a better place for future generations. It's a great way to meet and collaborate with other men who share your beliefs and ideals.
By cultivating the three cardinal virtues of brotherly love, charity, and truth, we enhance and fortify our personalities. Our values aren't only for when we're together; we try to incorporate them into everything we do.
There's also a lot more.
This website is a great place to start learning about Masons. What else do you need to know? In search of a local Mason who would be willing to offer his thoughts? You can contact your local lodge of Masons by sending an email, giving them a call, or stopping by in person.
A Mason is a spiritual and moral man who seeks out friendship with others who share his values. Freemasonry provides individuals with a methodical and structured approach to personal development centred on the Golden Rule: treat others as you would like to be treated.
Masonry is a profession with over 3.2 million practitioners worldwide, including over 40,000 in Ontario alone.
No matter your background or beliefs, you will be treated with respect.
Freemasons tend to be morally upstanding individuals, yet the fraternity is apolitical and does not encourage discussion of sectarian religions or political ideologies. Masonic members have a great deal of personal freedom, as long as their actions are consistent with the high moral standards represented by the square and compasses.
Masons are expected to be decent people in all aspects of their lives, from treating their families with respect to being trustworthy in the workplace to helping those in need to always acting with compassion and kindness. Each man has responsibilities to his family, his job, his faith, his community, and himself, and Masonry acknowledges that these must take precedence.
Masons proceed through three degrees, or levels, with each level presenting a different lesson through a different set of symbols. In order to answer questions like "Who am I?" and "Where did I originate from?" that are central to Masonic thought, one must earn their degrees. Like, why am I even here? And what happens after that?
A lodge is not a structure, but rather is the men who make it up.
The Masonic lodge is the bedrock of the fraternity. Here are the classrooms where Masonry's lessons on charity at home, integrity in commerce, politeness in public, objectivity in the workplace, compassion for the disadvantaged, and brotherly love are taught. Most lodges have prominent signs and may be found on the main streets of both large and small cities all around the world.
Ontario is home to more than 550 lodges, so it's likely that there's one that has meetings close by.
Masons are not members of a mysterious society and are often willing to share their expertise.
You may learn everything you need to know about Masons by visiting any large bookshop or library. Masonic lodges are easily identifiable due to their distinctive signage and directory entries, and members are easily recognized thanks to the jewellery they typically wear.
The so-called "Secrets" of Freemasonry are limited to the procedures by which an uninvited guest might establish his membership in the fraternity and gain entry to a lodge to which he would not have been granted admittance had he not done so.
Masonic Brotherhood, or the Bigger Family.
As a Mason, you have the option of expanding your horizons and enriching your knowledge by joining other orders:
Scottish Rite, York Rite, Shriners, and Knights Templar are all secret societies.
Masonry is a male-dominated organization, however members often include their wives and children in lodge social activities.
Lodges welcome women, girls, and boys who share Masonic beliefs to their various social and charity programs. Those interested in a more formal commitment can join one of the affiliated groups. Young Men can join DeMolay, and girls can choose between the International Order of the Rainbow for Girls and Job's Daughters International.
There are many other types of Masonic organizations, but at its core, Freemasonry is a fraternity, not a charity, social club, or other kind of charitable group. But aiding others via philanthropy is a major tenet of the fraternity's values.
Volunteerism and Community Service by Masons
Masons are expected to play an important role in their neighbourhoods. Here are just a few examples of Masonic involvement in community service projects:
The Masonic Foundation of Ontario is a registered charity with the Canada Revenue Agency that provides funding for a variety of worthwhile causes, including studies on hearing loss, scholarships for postsecondary students, assistance for those with autism spectrum disorder, studies on prostate cancer, and education initiatives aimed at young people about the dangers of substance abuse.
The Shriners run the largest network of hospitals in North America that treat children who have been burned or injured at no cost. Roughly 150 clinics, centres, and initiatives are part of the Scottish Rite Masons' network for treating language disorders in children.
Each district finances its own charitable initiatives independently.
Through its teachings, his Masonic associations, and a philosophy that has served the social requirements of men for ages, Masonry provides each man with an opportunity to better himself.
Tradition: As a Mason, you join a group that has been around for centuries and has its roots in that history. You'll feel like a part of a dynamic, expanding, and morally uplifting organization of men, from the first stonemasons who built some of Europe's most majestic architectural wonders to the present Masons who participate in various philanthropic foundations.
Personal Growth: Studying the Ritual and earning a Degree are intellectually stimulating activities that, when combined with committee work and lodge management, offer ample opportunity to hone skills in leadership and organization, discipline through dedication, poise and confidence, and the art of public speaking.
Fellowship: Participating in lodge initiatives, whether philanthropic or social in nature, gives one a sense of accomplishment by allowing them to make a difference, collaborate with others, and reap the rewards of hard work.
A Break from the Workaday Routine: Joining with lodge members in a fraternal culture helps make up for the loss of workplace fellowship caused by the modern work environment's emphasis on individualism and competition.
Masonic lodges are gathering places for men from all walks of life, where they can put their professional worries on hold and focus on building friendships instead.
The three tenets, or core principles, of Ancient Freemasonry best encapsulate these characteristics: brotherly love, relief, and truth. If you find these principles to be helpful, Masonry is open to you.
Fill out the form HERE to be contacted by a lodge member in your area or to get additional information. Depending on how interested you are, our reply could take some time. We reserve the right to contact you via email, phone, or regular mail in addition to the methods you have provided.
, © and 2023


text:
Browse: Home > 2013 > September > Train Industry Allies in U.S. Senate Move to Delay Deadline for Crash-Prevention Technology
Train Industry Allies in U.S. Senate Move to Delay Deadline for Crash-Prevention Technology
Prodded by railroads, four lawmakers introduce bill to postpone deadline for installing high-tech safety systems. The systems, known as Positive Train Control or PTC, aim to override human error and avert deadly collisions like the Chatsworth, Calif., commuter train crash that killed 25 people in 2008. Railroads are mandated to have PTC by the end of 2015 on trains carrying passengers or extremely hazardous materials such as chlorine. But, as FairWarning reported last year, the industry has pushed hard to relax the requirement and win more time to add the costly technology. Four senators who have received political contributions from the industry recently introduced a bill to extend the deadline another five to seven years, until at least 2020. The National Transportation Safety Board has called for the safety measures for more than two decades. Over the last decade, the agency has investigated 27 train crashes that killed 63 people that it says PTC could have prevented. The Associated Press
Federal poultry inspection proposal based on bad data, investigators say. The U.S. Department of Agriculture relied on incomplete and outdated data for its plan to extend a poultry inspection program to plants across the country, according to a report from the Government Accountability Office. The new procedures, piloted at 29 sites since 1998, let plants dramatically speed up processing lines and replace many government inspectors with poultry company employees, which the USDA said will boost efficiency and save money for taxpayers and consumers. In 2012, the agency proposed extending the procedures to most of the country's 239 chicken and 96 turkey slaughterhouses. But the agency in some cases used 20-year-old data to justify its proposal, and also applied data collected from chicken plants for turkey plants, the report found. The Washington Post
Smog-choked Beijing considers car-congestion fee. To prevent the catastrophic air pollution that blanketed the city last winter, Beijing officials are mulling a plan to limit cars on the road by charging car owners fees. Auto emissions account for one-third of the fine particulate air pollutants in congested parts of the city. The fees are part of a broader plan to cut fine particulate matter in the city by 25 percent by 2017 through curbing car sales, restricting driving, lowering speed limits and cracking down on industrial polluters like power plants, cement factories and oil refineries. London and Singapore have successfully introduced congestion pricing programs. The Wall Street Journal
Citing health concerns, state attorneys general call for stricter rules for wood-burning heaters. In a letter to the U.S. Environmental Protection Agency, attorneys general from several states, including Connecticut, Massachusetts and New York, threatened to sue if the EPA does not update its laws governing large wood-burners used in central heating systems. The burners are a major source of air pollution in many communities, the letter said, and wood smoke increases childhood asthma and contains carcinogenic pollutants that can harm the heart and lungs. One state attorney general said the EPA has worked on standards for some time, but the group was concerned the efforts may have stalled. Currently a patchwork of state and local rules cover the burners. The EPA said it would release a proposal for new rules soon. New Haven Register, GIMBY
Worker's electrocution death leads to 26 safety citations at Missouri steel manufacturer. The U.S. Occupational Safety and Health Administration's charges against the St. Louis Cold Drawn steel bar manufacturing plant in St. Louis, Mo., included 19 violations such as exposing workers to live electricity and failing to provide workers with appropriate safety equipment. In May, a worker was electrocuted when he reached into an electrical panel box to retrieve gloves stored there. OSHA, which proposed $51,800 in fines, in 2002 cited the company with seven violations at the plant, which employs about 90 people. OSHA, St. Louis Post-Dispatch
Compiled by Bridget Huber
Posted in Warning Wire | Leave a comment


Sensational views, one of Asia's premier business addresses and the world's highest urban microbrewery are not words you'd usually associate with one another but at LeVel33, all three harmoniously combine for a unique, multi-sensory experience. From the penthouse, guests can drink and dine in a stunning location where form and function effortlessly come together in one of Singapore's most stylish rooftop bars.
Industrial chic has never been so sophisticated. Shiny steel tanks welcome you in and two huge copper brew kettles dominate the main bar and dining room and the earthy tones and dark wood textures stand LeVel33 out as one of the most elegant places for a drink in the city.
One hundred and fifty-six metres up, the food menu created by Executive Chef James 'Jimi' Tegerdine is littered with modern European classics with an Asian twist but it's the beers that are the real stars of the show.
Interestingly for a fine dining restaurant of this nature, the menu is huge and eclectic featuring meats, fish and vegetables from all over the world and many of the dishes include LeVel33's beers. You'll find a number of pseudo-pretentious 'chef only' additions such as chicharrón and hay jus with the pork, pomegranate labne with the lamb and squid ink smoked yoghurt with the cod but it's testament to the team of exceptionally talented chefs that these dishes are delicious and served with elegance and style. For the lunch trade there is an executive set menu; for the weekend visitors, brunch is served every Saturday from 11.30am – 3.30pm and the British ex-pats can enjoy some home comforts with a traditional Sunday roast from 12.00pm – 3.30pm.
While the food is outstanding, the beers are the big draw at LeVel33. According to the LeVel33 website, 'the 33.1 Blond Lager, 33.15 India Pale Ale, 33.3 Stout, 33.4 House Porter and 33.9 Wheat Beer are brewed based on heritage recipes applying state-of-the-art technology by SALM & Co, one of Europe's oldest manufacturer of breweries.' Long gone are the days of customers being satisfied drinking weak American lager or mass-produced German beers. Singapore's discerning clientele expect a little more and LeVel33 delivers. They have a series of perma-available signature beers as well as quarterly-crafted seasonal brews that last, in their own words, 'until the tap runs dry.' While the focus is clearly on the beer, they have paid attention to the wine with a series of exclusive Mouton Rothschild premier vintages from the Bordeaux estate and a very well curated list from independent and artisan wine producers the world over.
The magnificent brew kettles; the sumptuous interior; the full-height glass façade; the timber and the leather furniture combine perfectly with the sensational view and has turned LeVel33 into one of Singapore's best rooftop bars.
Please Note: On the eve of public holidays, the Thursday – Saturday opening times apply.


text:
Q: Cannot find the embedded schemas in the assembly I have DefaultSchemaSet.xsd. Now I'm getting FileNotFoundException for the codes below. Give me any suggestion, please? May I know how to solve this?
public static void GetDefaultSchemas(string path, XmlSchemaSet schemas, ValidationEventHandler schemaValidationEventHandler)
    {
        using (var stream = Assembly.GetExecutingAssembly().GetManifestResourceStream(path))
        {
            if (stream == null)
            {
                throw new FileNotFoundException("Cannot find the embedded schemas in the assembly!");
            }

            var schema = XmlSchema.Read(stream, schemaValidationEventHandler);
            schemas.Add(schema);
        }
    }

A: In order to make sure you can access it from your code you need to ensure that the file's build action is set to "Embedded Resource"
To help further we really need to see where the file lies in your solution (to give you an exact answer), however in the mean time if you ensure that your parameter "path" follows the pattern:
[DefaultNamespace].[AnySubFolders].[filename.fileextension]

note without the square brackets

A: Check the format of the resource name:
DefaultNamespace[.Subfolder][...MoreSubfolers].FileName[.extension]

You need to set Build Action to Embedded Resource in project's file's properties.

Also, you need to check the namespace you use for your project:

Try to examine the available resources, so you can find if a particular one present:
        var executingAssembly = Assembly.GetExecutingAssembly();
        var resourceNames = executingAssembly.GetManifestResourceNames();
        foreach (var resourceName in resourceNames)
        {
            Console.WriteLine("Resource: " + resourceName);
            Console.WriteLine("Contents:");
            using (var sr = new StreamReader(executingAssembly.GetManifestResourceStream(resourceName)))
            {
                Console.WriteLine(sr.ReadToEnd());
            }
        }

Output:
Resource: EmbeddingTests.TextFile1.txt
Contents:
Hello
Resource: EmbeddingTests.NewFolder1.TextFile2.txt
Contents:
Hello 2

redpajama_set_name: RedPajamaStackExchange


text:
Home Fashion This New Photographic Project Captures The Beauty Of Trans Women
This New Photographic Project Captures The Beauty Of Trans Women
Model, self-love advocate and activist Khrystyana is celebrating the trans women community with an ethereal set of photographic portraits. And we're in love with them. Her recent project is inspired by The REAL Catwalk, an everybody-welcome body positivity catwalk that takes place each year in Times Square, New York. Khrystyana founded the event, during which people of all body types, ethnicities, genders and more are invited to celebrate themselves and each other by participating in an underwear-only 'catwalk'. It's a joyous statement of inclusivity and solidarity.
To celebrate PRIDE this year, Khrystyana wanted to create something similar to The REAL Catwalk to celebrate one of the LGBTQI+ community's most vulnerable groups: trans women. She said, "Fifty years ago this month, trans women of color were instrumental in starting the queer pride movement during the Stonewall Riots in New York. The progress that the LGBTQIA+ community has made since then can be traced back to the work of those women, like Marsha P. Johnson and Sylvia Rivera. Yet, despite half a century of progress, trans rights still fall behind those of others in the LGBT+ community."
It's time to stop cashing in on the Pride movement. These are the brands making a real difference to LGBTQ+ lives
13 trans women came together as models for the day. They were styled by Guvanch in high-fashion garments from current showrooms, and were shot by photographer Amanda Picotte. Both the ladies' clothes and shoot's backdrops are in the loveliest shades of pink and blue, with dashes of white running throughout, to symbolise the colours of the Trans Flag. "The elegant and elevated aesthetic is purposeful, aiming to provide needed representation that is not objectified," Khrystyana told us. "I've been deeply affected by the tragic events that trans communities have been experiencing. Now, more than ever, I want to highlight the voices of trans women."
And that she did. The resulting photographs are absolutely beautiful – see for yourself below.
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The latest studies have shown that insomnia is more prevalent than anyone would think. For instance, the study has shown that about 58% of the adult population in the US alone had problems with sleep that could be characterized as insomnia at least a few times a week.
This percentage is somewhat lower when we are considering more frequent instances of insomnia, but in any case, this number is huge. It is therefore quite understandable that the need for insomnia treatments is equally as big. In this article, you are going to learn about different treatment options for insomnia and how Ambien compares to them.
First of all, we should mention treatments that do not involve medications. There are different treatments belonging to this category and they are of differing efficiency.
Also, it has to be noted that some people will respond better to such treatments while others are going to find them completely useless. For instance, some people may benefit a lot from simply taking care of their sleep hygiene.
This is a strange-sounding expression and it mainly involves trying to set up regular sleeping habits and absolute maximization of the sleeping process by doing everything possible to encourage healthy sleeping patterns. Cognitive behavioral therapy also exists for insomnia and its effects also vary from one person to the other.
However, the majority of people who are diagnosed with insomnia will be prescribed medications as the aforementioned treatments will provide very little success. There are so many possible medication options for insomnia that it would be impossible to go through all of them.
We will therefore try and compare as many of them as possible to Ambien which is in our opinion the best treatment for insomnia on the market.
The class of drugs that is most commonly used for insomnia are benzodiazepine drugs which bind to GABA receptors and thus provide increased levels of GABA neurotransmitter which leads to hypnotic effects.
Some of the drugs from this class that are used for insomnia include midazolam, temazepam, triazolam, nitrazepam, etc. These medications have been found to be quite efficient in treating insomnia but there are also many unwanted effects of these medications that make them less than a perfect option. For instance, they are known for their potential for causing dependence and tolerance, as well as a range of side effects.
Opioids, which are more commonly used for treatment of pain, are also sometimes prescribed for insomnia, mainly when it is associated with pain stemming from injuries, post-operative pain, as well as certain chronic pain conditions. However, these medications also have their downsides, more noticeably the potential for dependence as well as long time disturbance in sleep.
Antidepressants are also known for their hypnotic effects and they are at times prescribed for insomnia. However, these medications are associated with a large number of side effects that can be quite serious and that will do more harm than the medication will do good.
In addition, these medications can also disturb the sleep architecture and also cause dependence and rebound insomnia.
Other classes of medications that are sometimes used in treatment of insomnia include atypical antipsychotics, antihistamines, melatonin as well as some other substances, either natural or even illegal such as marijuana.
Some people even try to treat insomnia with alcohol, which is a very bad idea as it can lead to adverse effects on the sleep patterns and also cause insomnia due to certain processes in the body that are activated by drinking alcohol.
Ambien belongs to the nonbenzodiazepine drugs that are used for treatment of insomnia and it is one of the most efficient treatments for this problem. Its efficiency is similar to that of benzodiazepine drugs, only without as many adverse effects and weaker potential for causing tolerance and dependence.
We need to add that it is only useful in cases of insomnia involving problems falling asleep and not awakenings or early awakening in the morning. All in all, it is our opinion that Ambien provides the best results to adverse effects ratio, making it the superior treatment for insomnia.


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text:
David Blaine announced as December Guest Curator for Art For Freedom
by MT2013 · December 7, 2013
Madonna has confirmed David Blaine as the December guest curator for Art for Freedom. Guest curators collaborate with Madonna to select daily submissions to be showcased on artforfreedom.com.
"Madonna, who has always been an incredible inspiration, invited me to be a part of Art for Freedom. It's an amazing platform to bring artists together and I look forward to seeing the brilliance this generates."
"I am excited David is signing on as guest curator. This is only the beginning of Art for Freedom bringing artists together to change the world." commented Madonna.
As part of the Art For Freedom initiative, David Blaine will work with Madonna to select one artist from their respective month whose creative expression demonstrates a unique view of the fight for human rights. Madonna will then award a $10,000 grant to a nonprofit organization of the winning artist's choice. All projects must be focused on the values of Art For Freedom.
The latest freedom fighters chosen to receive an Art for Freedom grant are Amber Fares and the Speed Sisters – a documentary about the Middle East's first all women motor racing team. Against a backdrop of social and political upheaval, Speed Sisters presents an inspiring look into the drive to be true to oneself. The grant will go towards finishing the film. You can see more on the project on Vimeo by clicking here.
Launched in September 2013, Art For Freedom is a global digital initiative, led by Madonna in partnership with VICE Media, designed to fuel free speech – to respond, address and protest persecution and discrimination around the world. It is an online public art project encouraging people to express their personal meaning of freedom and revolution, in the form of video, music, poetry, and photography. Public submissions become part of the Art For Freedom website: contributors can join the project by uploading original artwork or tagging original posts #artforfreedom. The project was launched with the film secretprojectrevolution, co-directed by Madonna and Steven Klein.
VICE Media continues to serve as co-curator of Art for Freedom, leveraging VICE's extensive global network of filmmakers, artists, writers, musicians, museums, and more, to contribute works to the project.
Tags: Art for Freedom
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"Inside Michigan Football" is the title of the next generation "Michigan Replay", which as we all know, died a quiet death at the end of the Lloyd Carr administration after a 30+ year run.
There's not many folks out there who were too sad to see Michigan Replay go away. Sure, it was a great show for us die-hards. But a half hour of Brandy and Lloyd waxing poetic about the game that was, got a tad dry and stale. Lloyd was not a big fan of the camera.
So, in keeping with the routine in Ann Arbor this year...out with the old and in with the new. "Inside Michigan Football" will be a new show hosted by Brandy and Rich Rod of course. Doug Karsch will be added the show's lineup...as a roving-reporter I assume.
The show will air on August 28th at 6:30pm on FSN Detroit, and will be replayed on ABC-7 and the Big Ten Network. Because of legal stipulations, it will not be posted on mgoblue.com. 15 episodes in total will air over the season following the same schedule every week.
However, a program called "Michigan Rewind" will air on mgoblue.com after games and will feature 8 to 10 minutes of highlights, analysis and interviews with coaches and players.
All I ask is that they keep the vintage Michigan Replay music...that was pure gold! Nothing says Michigan football like 70's R&B music!


East London may be a hipster's playground, but parts of it are still very much the preserve of pinstripes and long lunches.
The City of London is the heart of one of the world's financial districts. It lies only a few minutes walk away from the fried chicken pop-ups and markets of Shoreditch and Brick Lane, but it might as well be a world away.
London's trends seem to change with dizzying speed, but the pubs of the City –always a capital C, this is money we're talking about – don't need to chase the tourists or the Instagram crowd. They cater for the local legal and financial workers, those dipping in for a pint or a glass of wine before a train ride to the leaguer suburbs.
Some of these pubs – dark wood, gloomy interiors, overwhelmingly male clientele – seem to be little changed from the London of a century ago. Many of them are tucked away in side passages and alleyways that, before the age of Google Maps, meant they were hard to find.
I found this pub on a warm springs day back in 2014, when my mum was visiting from New Zealand. There was barely a cloud in the sky and the heat poured off the concrete; we dived into a fantastic, wood-panelled pub tucked into an alleyway.
Outside were a few hardy lunchtime drinkers soaking up the Sun. The windows were arranged so half were normal and half obscured, throwing the figure on the left here into a strange, surreal shape.
I'd taken along my Lomo LC-Wide, loaded with original Agfa CT100 Precisa, one of the best slide films to cross-process. The LC-Wide's not just for wide-open vistas and streets; here, I managed to squeeze in as much of the window as possible, with the man on the right fitting inside the clear window. We need him to be crisp and clear to throw his mystery drinking mate into sharp relief. It wouldn't be the same pic without him.
I love stopping by a pub in the middle of a hot day anyway – but armed with a camera and a view out the window, those visits can take on an extra dimension.


THE Thai House has been serving authentic Thai food for approximately twelve years now and is still welcoming customers old and new.
Tucked off the beaten track between Wokingham and Crowthorne (near the Downshire Golf Club in West Road), the Thai House offers a full a la carte menu in the restaurant on Thursday, Friday and Saturday evenings, while on Monday to Friday lunchtimes (midday to 3pm), there is a popular Thai lunchtime special available in the Hideout's licensed bar area, with a choice of six different Thai lunches for £4.40.
Larger party bookings can be arranged in the restaurant between Monday and Thursday evenings (up to 60 people) with set menus ranging from £17.50 to £22.50 per head.
During December there is a special Thai evening set menu of four courses for £25 per head or for lunchtime, a special Thai menu for £10 per head (served in the bar area or function room).
If you would like to try a taste of Thailand, bookings can be made on (01344) 778686.
THE recently refurbished Royal India restaurant, in Peach Street, Wokingham, offers traditional Indian cuisine in contemporary surroundings.
Established 26 years ago, the chefs take pride in providing the best Indian food around.
Everything is freshly prepared and cooked on the premises using only the finest ingredients.
The subtle use of herbs and spices emphasises the different flavours and the aromas serve only to enhance the special dining experience.
The exclusive menu will leave you spoilt for choice, but for the perfect dining experience allow the staff to recommend a mouth-watering dish to suit your taste.
The restaurant has built up a strong client base over the years who have remained loyal, with many new customers coming from word of mouth.
With the new design, larger parties can be catered for, but Royal India also lends itself to offer a dining experience for two or four people.
And if you simply can't get away from the house, but yearn for the authentic cuisine, you can always opt for their takeaway service, confident in the knowledge that the dishes will be up to their usual restaurant standard.


text:
Q: Read files in Python based on their semantic numbering I'm trying to iterate over files in a directory using the following command in python 3.6:
for filename in os.listdir(my_dir)

My files are numbered incrementally, like out1, out2, ...,out10, out11, .... Unfortunately, iteration over the files using the above command results in out1, out10, out11 instead of out1, out2, out3, .... It might be correct from file system point of view, but semantically wrong.
How can we get the right output?


FireFTP gives you the power of a top-notch FTP client from within your Firefox browser. It can handle multiple accounts and remember different logins, passwords, and connection settings for each. It supports authenticated TSL, authenticated SSL, and implicit SSL for secure transfers, drag and drop, and CHMOD changes.
FireFTP Free Download - we do not host any FireFTP torrent files or links of FireFTP on rapidshare.com, depositfiles.com, megaupload.com etc. All FireFTP download links are direct FireFTP download from publisher site or their selected mirrors.


text:
CASH Revisited
Rick McKay
Jodie McKay
THEATRE & IN CONCERT
CASH Revisited is a theatrical production following the career and music of Johnny Cash through five decades of Rockabilly, Rock 'n' Roll, and Country music, eventually shattering the boundaries of specific genre, and achieving cult status across the whole field of popular music.
This two-hour journey through the musical milestones of his career presents the very biggest and best loved hits from Cash's huge repertoire including 'Cry Cry Cry', 'Big River', 'I Walk The Line', 'Folsom Prison Blues', 'Ring of Fire', 'A Boy Named Sue', 'A Thing Called Love' the immensely powerful 'Hurt', and many more…
Featuring Rick McKay in the lead role with special guest Jodie McKay as June Carter Cash, this wonderful live show also features the fabulous live band 'Starkville', who recreate the sound of Johnny Cash's music from 1955 to 2003 with a stunning authenticity and close attention to detail.
CASH Revisited promises to be a musical experience you won't forget in a hurry and represents the closest you'll ever get to seeing "The Man In Black" live on stage!
In addition to our theatre production Rick McKay and Starkville can also bee booked for festivals, concert events and music venues in their own right. The show comes fully elf contained with a P.A. system, or can perform using the sound and lighting system in your venue.


text:
Q: spyOn function not called I have a function
getList() {
        return this.listFactory
            .fetchList()
            .then((data) => this.generateDsisplay(data));
}

and already mocked the fetchList return
mocktListRepository.fetchList.and.returnValue(PromiseUtil.transformAsResolvedPromise(listPage));

but in my unit test still fails. I have no idea why. The test will call the generateDsisplay
describe('getList()', () => {
        it('should call generateDsisplay', () => {
            spyOn(component, 'generateDsisplay');

            component.getList();

            expect(component.generateDsisplay).toHaveBeenCalled();
        });
    });

A: The asynchronous method call this.listFactory.fetchList() needs to be synchronized in your unit test. Using fakeAsync and tick from @angular/core/testing, this can be done as follows.
import { fakeAsync, tick} from '@angular/core/testing';
describe('getList()', () => {
    it('should call generateDsisplay', fakeAsync(() => {
        spyOn(component, 'generateDsisplay');

        component.getList();
        tick();

        expect(component.generateDsisplay).toHaveBeenCalled();
    }));
});

As an alternative, you may also try the async/await as follows.
 describe('getList()', () => {
     it('should call generateDsisplay', async () => {
         spyOn(component, 'generateDsisplay');

         await component.getList();

         expect(component.generateDsisplay).toHaveBeenCalled();
     });
 });

Again another approach using the done callback.
 describe('getList()', () => {
     it('should call generateDsisplay', (done) => {
         spyOn(component, 'generateDsisplay');

         component.getList()
             .then(data => {
                 expect(component.generateDsisplay).toHaveBeenCalled();
                 done();
             })
             .catch(err => fail(err));
     });
 });


text:
Q: How to create internal value in a module using OCaml/Reason I have the following module:
type userBuilderType = {
  mutable name: string,
};

module BuilderPattern = {
  let builder () => {
    name: "",
  };
  let setName = fun name => builder.name = name;
  let getName = builder.name;
};

BuilderPattern.setName("Charles");
Js.log(BuilderPattern.getName);

It accomplishes the following:

*

*Creates type for setter

*builderName object for setting + getting
In addition I would like to:

*Be able to retrieve name using a JS.log on getName function

However, in this instance I get back the following error:
This is: unit => userBuilderType But somewhere wanted: userBuilderType

Any suggestions as to how I properly set up the setter/getter is more than appreciated. Thank you.

A: There are numerous problems with the code in your question, several of them purely syntactic. The github code makes a bit more sense, but the main problem you have is that you don't make an instance of your data anywhere.
I think this is what you want, where an instance is constructed and passed to the getter and setter:
type userBuilderType = {
  mutable name: string,
  mutable age: int,
  mutable phone: string,
  mutable address: string
};

module BuilderPattern = {
  let builder () => {
    name: "",
    age: 0,
    phone: "",
    address: ""
  };
  let setName builder name => builder.name = name;
  let getName builder => builder.name;
};

let myBuilder = BuilderPattern.builder ();

BuilderPattern.setName myBuilder "Charles";
Js.log(BuilderPattern.getName myBuilder);

But this also seems like a valid interpretation of your intent, where the state is kept globally (which is usually a very, very bad idea):
type userBuilderType = {
  mutable name: string,
  mutable age: int,
  mutable phone: string,
  mutable address: string
};

module BuilderPattern = {
  let builder = {
    name: "",
    age: 0,
    phone: "",
    address: ""
  };
  let setName name => builder.name = name;
  let getName () => builder.name;
};

BuilderPattern.setName "Charles";
Js.log(BuilderPattern.getName ());

In both cases the problem boils down to confusing a function taking a single unit argument with just a let binding, in various ways.


text:
.OTEwMA.MzAyODg
From Transcribe Wiki
Revision as of 16:45, 31 March 2018 by Debolina (talk | contribs)
[DOC. No.14]
REPORT OF THE ATTORNEY GENERAL
LINN BANKS, Esq. Speakers of the House of Delegates. In the pursuance of the act of March 1836, I have the [honor?] to submit to the general assembly, through you, the accompanying statement of the causes of the commonwealth in which it is my duty to appear as her counsel. Most respectfully, Your obedient servant, S.S. BAXTER, [Attorney General?] A. STATEMENT OF THE CAUSES in which it is the duty of the Attorney General to represent the Commonwealth in the Circuit Superior Court of the City of Richmond and County of Appeals, and the General Court.
Superior Court of Richmond and Henrico, on the Chancery side. Attorney General vs. Cottle and Reynolds.- A suit to subject the lands of Cottle, sheriff of Kanawha, and his sureties, to the payment of money due from him for collections made as sheriff. The process issued has not been executed.
Same vs. Riddle and others.- A suit against William Riddle, sheriff of Berkely, and his deputies, to recover militia fines of 1816. Process not served.
Same vs. Ricks.- A suit set aside conveyance of property made by George Winston, in fraud of the commonwealth's judgement against him. This cause is on the argument docket,and probably be tried at this term.
Same vs. Rhodes and others.- A suit to set aside a sale of the slaves of Mathew Rhodes, made under an execution of the commonwealth, and a conveyance of land made by Bernard to Leake. Bernard is dead and has no representative. The case is ready to the other parties.
Same vs. Irby.- To subject the land of Irby, sheriff of Charles City, to the payment of the judgement against him as sheriff. Process has not been executed on all parties.
Same vs. Fischer and others.- A suit to recover from Fisher and Lackland, inspectors of tobacco at the public warehouse, the balance due from them as inspectors. Ready for hearing as to all the parties except Fisher.
Same vs. Haines and others.- A suit against the sureties of W. Nall, who was sheriff of Rockingham in the year 1785, and failed to pay the revenue of that year. the cause is not ready for hearing. From the number of defendants I doubt whether they can be brought before the court.
Same vs. Manning.- A judgement was obtained against Ralph Pigot in Norfolk superior court, for an assault. Pigot conveyed his property to his family. The suit is to set aside the conveyance. All the parties are not yet before the court.
Same vs. Nicholas.- Suit against Nicholas, former clerk of Dinwiddie, to recover a balance of taxes due from him. The account has been referred to a commissioner, and no report has been made.
Same vs. Dryden.- A suit to recover money collected by Dryden, as clerk of Kanawha. This accounts were recommitted to a commissioner, and no report has been made.
Same vs. Jones.- To recover a debt due from defendant to commonwealth. Defendant is dead, and no representative known to me.
Same vs. Preston.- A suit against the representatives and sureties of the late Gen. John Preston. the debt due by bond has been settled. This a debt due to the literary fund not covered by his official bond. All his estate has been applied to discharge the commonwealth's claim, except some old bonds alleged to be due him. These bonds are now filed in the record. I do not know what to do with them.
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text:
A Severe Case of Congenital Thrombotic Thrombocytopenia Purpura Resulting from Compound Heterozygosity Involving a Novel ADAMTS13 Pathogenic Variant
Erin Conboy, Paige I. Partain, Deepti Warad, Michelle L. Kluge, Carola Arndt, Dong Chen, Vilmarie Rodriguez
Pediatric and Adolescent Medicine
We report a 9-year-old Chinese girl with congenital thrombotic thrombocytopenic purpura found to be a compound heterozygote for 2 pathogenic variants in the ADAMTS13 gene, including a novel variation. The girl suffered from recurrent, life-threatening episodes of thrombocytopenia and hemolysis, and laboratory testing showed ADAMST13 enzyme activity of <5%. Sequencing of the ADAMTS13 gene revealed a previously reported missense variant, c.1787C>T (p.Ala596Val), and a novel duplication defined as c.1007-1025dup19 (p.Asp343Leufs∗53); the duplication is predicted to result in a premature stop codon and protein truncation. We propose that this novel variant is partly responsible for the patient's early-onset and severe phenotype.
Journal of Pediatric Hematology/Oncology
https://doi.org/10.1097/MPH.0000000000000895
Pathogenic variant
TTP
Thrombotic thrombocytopenic purpura
Upshaw-Schulman syndrome
10.1097/MPH.0000000000000895
Dive into the research topics of 'A Severe Case of Congenital Thrombotic Thrombocytopenia Purpura Resulting from Compound Heterozygosity Involving a Novel ADAMTS13 Pathogenic Variant'. Together they form a unique fingerprint.
Purpura Medicine & Life Sciences 100%
Thrombocytopenia Medicine & Life Sciences 76%
Thrombotic Thrombocytopenic Purpura Medicine & Life Sciences 54%
Nonsense Codon Medicine & Life Sciences 46%
Heterozygote Medicine & Life Sciences 43%
Hemolysis Medicine & Life Sciences 42%
Enzymes Medicine & Life Sciences 22%
Conboy, E., Partain, P. I., Warad, D., Kluge, M. L., Arndt, C., Chen, D., & Rodriguez, V. (2018). A Severe Case of Congenital Thrombotic Thrombocytopenia Purpura Resulting from Compound Heterozygosity Involving a Novel ADAMTS13 Pathogenic Variant. Journal of Pediatric Hematology/Oncology, 40(1), 60-62. https://doi.org/10.1097/MPH.0000000000000895
A Severe Case of Congenital Thrombotic Thrombocytopenia Purpura Resulting from Compound Heterozygosity Involving a Novel ADAMTS13 Pathogenic Variant. / Conboy, Erin; Partain, Paige I.; Warad, Deepti; Kluge, Michelle L.; Arndt, Carola; Chen, Dong; Rodriguez, Vilmarie.
In: Journal of Pediatric Hematology/Oncology, Vol. 40, No. 1, 2018, p. 60-62.
Conboy, E, Partain, PI, Warad, D, Kluge, ML, Arndt, C, Chen, D & Rodriguez, V 2018, 'A Severe Case of Congenital Thrombotic Thrombocytopenia Purpura Resulting from Compound Heterozygosity Involving a Novel ADAMTS13 Pathogenic Variant', Journal of Pediatric Hematology/Oncology, vol. 40, no. 1, pp. 60-62. https://doi.org/10.1097/MPH.0000000000000895
Conboy E, Partain PI, Warad D, Kluge ML, Arndt C, Chen D et al. A Severe Case of Congenital Thrombotic Thrombocytopenia Purpura Resulting from Compound Heterozygosity Involving a Novel ADAMTS13 Pathogenic Variant. Journal of Pediatric Hematology/Oncology. 2018;40(1):60-62. https://doi.org/10.1097/MPH.0000000000000895
Conboy, Erin ; Partain, Paige I. ; Warad, Deepti ; Kluge, Michelle L. ; Arndt, Carola ; Chen, Dong ; Rodriguez, Vilmarie. / A Severe Case of Congenital Thrombotic Thrombocytopenia Purpura Resulting from Compound Heterozygosity Involving a Novel ADAMTS13 Pathogenic Variant. In: Journal of Pediatric Hematology/Oncology. 2018 ; Vol. 40, No. 1. pp. 60-62.
@article{283bfc6969304dbf8d9e47e019428b40,
title = "A Severe Case of Congenital Thrombotic Thrombocytopenia Purpura Resulting from Compound Heterozygosity Involving a Novel ADAMTS13 Pathogenic Variant",
abstract = "We report a 9-year-old Chinese girl with congenital thrombotic thrombocytopenic purpura found to be a compound heterozygote for 2 pathogenic variants in the ADAMTS13 gene, including a novel variation. The girl suffered from recurrent, life-threatening episodes of thrombocytopenia and hemolysis, and laboratory testing showed ADAMST13 enzyme activity of <5%. Sequencing of the ADAMTS13 gene revealed a previously reported missense variant, c.1787C>T (p.Ala596Val), and a novel duplication defined as c.1007-1025dup19 (p.Asp343Leufs∗53); the duplication is predicted to result in a premature stop codon and protein truncation. We propose that this novel variant is partly responsible for the patient's early-onset and severe phenotype.",
keywords = "ADAMTS13, Congenital, Mutation, Pathogenic variant, TTP, Thrombotic thrombocytopenic purpura, Upshaw-Schulman syndrome",
author = "Erin Conboy and Partain, {Paige I.} and Deepti Warad and Kluge, {Michelle L.} and Carola Arndt and Dong Chen and Vilmarie Rodriguez",
note = "Publisher Copyright: {\textcopyright} Copyright 2017 Wolters Kluwer Health, Inc. All rights reserved. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",
doi = "10.1097/MPH.0000000000000895",
journal = "Journal of Pediatric Hematology/Oncology",
T1 - A Severe Case of Congenital Thrombotic Thrombocytopenia Purpura Resulting from Compound Heterozygosity Involving a Novel ADAMTS13 Pathogenic Variant
AU - Conboy, Erin
AU - Partain, Paige I.
AU - Warad, Deepti
AU - Kluge, Michelle L.
AU - Arndt, Carola
AU - Chen, Dong
AU - Rodriguez, Vilmarie
N1 - Publisher Copyright: © Copyright 2017 Wolters Kluwer Health, Inc. All rights reserved. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.
N2 - We report a 9-year-old Chinese girl with congenital thrombotic thrombocytopenic purpura found to be a compound heterozygote for 2 pathogenic variants in the ADAMTS13 gene, including a novel variation. The girl suffered from recurrent, life-threatening episodes of thrombocytopenia and hemolysis, and laboratory testing showed ADAMST13 enzyme activity of <5%. Sequencing of the ADAMTS13 gene revealed a previously reported missense variant, c.1787C>T (p.Ala596Val), and a novel duplication defined as c.1007-1025dup19 (p.Asp343Leufs∗53); the duplication is predicted to result in a premature stop codon and protein truncation. We propose that this novel variant is partly responsible for the patient's early-onset and severe phenotype.
AB - We report a 9-year-old Chinese girl with congenital thrombotic thrombocytopenic purpura found to be a compound heterozygote for 2 pathogenic variants in the ADAMTS13 gene, including a novel variation. The girl suffered from recurrent, life-threatening episodes of thrombocytopenia and hemolysis, and laboratory testing showed ADAMST13 enzyme activity of <5%. Sequencing of the ADAMTS13 gene revealed a previously reported missense variant, c.1787C>T (p.Ala596Val), and a novel duplication defined as c.1007-1025dup19 (p.Asp343Leufs∗53); the duplication is predicted to result in a premature stop codon and protein truncation. We propose that this novel variant is partly responsible for the patient's early-onset and severe phenotype.
KW - ADAMTS13
KW - Congenital
KW - Mutation
KW - Pathogenic variant
KW - TTP
KW - Thrombotic thrombocytopenic purpura
KW - Upshaw-Schulman syndrome
U2 - 10.1097/MPH.0000000000000895
DO - 10.1097/MPH.0000000000000895
JO - Journal of Pediatric Hematology/Oncology
JF - Journal of Pediatric Hematology/Oncology


The polar bear, left was killed after attacking a German cruise ship worker on Norway's Svalbard archipelago last week.
Svalbard has seen five such polar bear attacks in 40 years.
The 2011 bear attacked a group of 14 on a British school trip. A 17-year-old died and that bear was also killed.
Polar bears are protected in Norway unless, of course they maul and/or kill people.


Last year I was VERY faithful about sending out a weekly email to all the CSA subscribers about what was in their box and how to use it or different recipes using their weekly ingredients.
Here we are 6 weeks in and this is the first post/email about what our boxes contain!
But… it's a good thing. Over the last seven months I've had the rug pulled out from under me and it took me a long time to slowly get back to my normal activity level. I really didn't have the motivation to do much of anything. That has since mostly returned, but I definitely don't have the desire to be quite so busy as I was in the past.
We still have a crazy amount of things on our plates, but I feel like I'm doing a better job of saying no, slowing down and taking a nap if I want one, reading a book with the littles, rocking the 'baby' (almost 2 year old), and trying to make the most of each day and enjoy it for what it holds.
So the emails I was faithful to send last year and the two to three weekly posts on the blog have been slowed. I don't stress about it and post when I feel like there is something to say or something I want to share!
We find ourselves well into summer with yummy veggies and fruits gracing our tables and filling our bellies. Here is what's in the boxes this week and some ideas of what I may do with it this week!
Tomatoes – Never a hard time using these! Perfect for summer burgers or salmon burgers. Lovely to make pico de gallo or fresh salsa, and delicious with basil and a sprinkling with balsamic vinegar. A summer salad favorite of ours is a Mediterranean Pepper Salad which is a tried and true around here!
Turnips – I'm not usually a fan of root veggies like turnips and radishes… but I fermented the radishes a few weeks back and I think I'm going to do the same with these. It took out the peppery flavor and made them much more mild but still crunchy. I found this lacto-fermented recipe for the turnips and am going to give it a go!
Poblano peppers – These peppers are a quite spicy if raw, but if roasted take on a bite, but it lessens and the roasted pepper flavor is delicious! I make a sweet and spicy salsa for homemade chicken nuggets which is super yummy! Roast the peppers, peel them, puree with fresh pineapple. Then simmer until thick. Delicious! It's a recipe from Paleo Parent's Eat Like a Dinosaur cookbook, but I found the recipe here.
Red peppers – These we tend to eat raw as a side for lunches or with some hummus. I do add them to the Mediterranean Salad and fresh salsas. These usually aren't too hard to use!
Bok choy – We JUST ate this on Sunday night! One of our favorite meals is my Sweet and Spicy Asian Pork Shoulder recipe . It's super simple crockpot recipe that doesn't taste like your typical roast! I add the bok choy at the end! Delish!
Lettuce – Another veggie that we are all very used to. Caesar salad has been a new fave with homemade gluten free croutons and my own recipe for our Caesar dressing! It's never met with sad faced. ALL are happy to have salad on these nights! We also really enjoy chicken lettuce wraps as well!
Carrots – Another raw addition to our typical lunches! Also good afternoon snacks. One of my fondest memories I share with my Dad is eating raw carrots together with a generous sprinkling of salt on them! My mom would never add the salt, but Dad and I LOVED them that way! I should introduce my kids to them!!! A favorite this past winter was roasted carrots with olive oil (or butter if you can have it) and a generous sprinkling of dried dill. FANTASTIC!!!
So there you have it! Our week in veggies! Enjoy! And feel free to share recipes that you enjoy as well! It's always good to have new ideas!
Next Will We Have a Second Rainbow Baby?


This drink is good,not my favorite but not bad at all!!!
I tend to skip meals which is not smart. But these ensure I get my breakfast or a quick snack when I'm busy. I'm not trying to loss weight anymore, but I still love these. It's nice to have a protein drink that is not milk based or chocolate/strawberry/vanilla.
It tastes so good, I will drink it just for taste.
These are so delicious. Pineapple Orange, Peach Tea and the Wildberry flavor. As one reader said I also add twice the water.
Yea, these drinks are very very good. I am a lifetime pepsi drinker and this and the cran-grape are my drinks by choice now. Give em a try and you will be impressed. Oh and there much cheaper that that ideal protien junk.
Please contact us to submit your review for Protein Diet Fruit Drink Raspberry Lemonade (7 ct) - BariWise.


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Philippines declares battle with Islamist rebels over in Marawi City
The Philippines announced on Monday the end to five months of military operations in a southern city held by pro-Islamic State rebels, after a fierce and unfamiliar urban war that has marked the country's biggest security crisis in years.
Offensive combat operations were terminated after troops prevailed in what was the last stand against rebel gunmen who clung on inside several buildings in the heart of Marawi, and refused to surrender.The bodies of 40 of those fighters and two of their wives were found on Monday in two buildings and a mosque in the battle zone. Artillery and automatic gunfire were still heard on Monday and Reuters journalists saw flames behind a mosque.


You are here: Home / Podcasts / Yes to the Prom Dress Collection Drive and Giveaway!
Yes to the Prom Dress Collection Drive and Giveaway!
ARTICLE/ PODCAST. Prom dresses are expensive. Lele Keaton and Jenny Urban have a fun solution. Recycle. Need a dress? Got a dress?
Leonora Keeton December 10, 2018 · Facebook.
My friend, Jenny McCoy-Urban, and I are trying something new. We are so excited to announce that we are starting a prom dress collection and giveaway — Say Yes to the Prom Dress!! Prom is sooooo expensive and we all have dresses in our closets that could be put to good use. So, if you need closet space for yourself or your daughter, please send your new or GENTLY used cocktail and formal dresses our way. Details are on the poster. Thanks!
Listen to Jenny Urban chat with Reuben and Livvy about her "Say Yes to the Prom Dress" project.
The Coastside's only live, call-in talk radio show, Coastal Windage features Coastside issues, hot topics, and live comments from Coastsiders in real time. Finally, the people of the Coastside have an opportunity to participate in their own community. Co-hosts Reuben TruthMaker and Livvy Streetwise provide a curated and encouraging forum for discussion while regaling listeners with their informed, entertaining, and insightful takes on a full spectrum of topics. This is not a platform for endless arguing and posturing. This is free-range thinking applied to local issues and daily lives with expansive, explorative discussion. No dogma, no entrenched positions, no talking points or political agendas — just two Coastsiders with the time and curiosity to dive deep and go anywhere.
To be on the show, listen from 9:00 a.m. to 10:00 a.m. on Fridays and call 650.560.9851. You can also email Reuben and Livvy Streetwise with your comments at coastalwindage@gmail.com.
A 15-year resident of El Granada, Reuben TruthMaker is a dedicated husband, dad, coach, community volunteer, and creative professional. He is also a confirmed cynic, a notable futurist, and a passionate iconoclast forever seeking the greater good. Voted "Most Likely to Wear a Tin Foil Hat" during his senior year of high school, Truth loves a good conspiracy theory. Humor him.
Livvy and her family have lived here on the coast for 15 years and look forward to the next 15! She is an active volunteer in the community, occasional coach for her child's soccer team, and champion of good vibes. As a 'foil' to Reuben's cynicism, Livvy tries to look on the bright side of the issues, however, she has been known on many occasions, to break out the ol' soapbox, asking "why the heck can't we all just get along"???


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David McManus
Mr. McManus has served as a Director of the Company since August 2011. Mr. McManus is currently non-executive director for a number of listed companies, including Hess Corporation, Rockhopper Exploration, and Costain Group PLC. Mr. McManus has 40 years of technical, commercial, and general management experience across all aspects of the international oil and gas business, having held various executive roles at Pioneer Natural Resources, BG Group, ARCO, Ultramar, and Shell. As Chairman of Cape plc, Mr. McManus worked on several global LNG projects such as Sakhalin, Qatargas, and North West Shelf.
João Saraiva E Silva – Director
Mr. Saraiva e Silva joined the Board in September 2019. Mr. Silva is an investment professional with the Seatankers Group. Prior to joining Seatankers, Mr Saraiva e Silva was responsible for energy investments at L1 Energy (2013 to 2018), served as Managing Director of Carlyle's International Energy Partners fund, and was responsible for energy and infrastructure investments at Och-Ziff Capital Management (2008 to 2011). Prior to Och-Ziff, Mr. Saraiva e Silva spent approximately nine years in the investment banking division of Goldman Sachs advicing on M&A and capital markets transactions across the broad energy sector. Mr. Saraiva e Silva has an Economics degree from the Nova School of Business and Economics.
Nikolai Grigoriev
Mr. Grigoriev has served as a Director of the Company since September 2017. From 2008 to 2016, Mr. Grigoriev served as Managing Director, Shipping at Gazprom Marketing & Trading (GMT) in London and Singapore. Prior to GMT, Mr. Grigoriev worked for BG Group and Merrill Lynch in Houston and London in senior LNG shipping, commercial and corporate finance roles. Nikolai holds a B.Sc. in Navigation from Admiral Makarov State Maritime Academy in St. Petersburg, Russia and an MBA from INSEAD in Fontainebleau, France.
Ola Lorentzon
Mr. Lorentzon has served as a Director of the Company since June 2017. He served as Principal Executive Officer of Golden Ocean Group Limited from 2010 to 2015 and held the role as Chief Executive Officer of Frontline Management AS from 2000 to 2003. From 1986 to 2000, Mr. Lorentzon served as Chief Executive Officer of ICB Shipping. Mr. Lorentzon is also a Director and Chairman of Golden Ocean Group Limited and a Director of Frontline Ltd., both related parties of Geveran, and Erik Thun AB.
Marius Hermansen
Mr. Hermansen has served as a Director since December 2015. He serves as Head of Sale & Purchase/Newbuilding for Seatankers Management Norway AS, a related party of Geveran. Mr. Hermansen started out his career as a trainee with AP Moller-Maersk and went on to work over 10 years at Fearnleys Shipbrokers. Mr. Hermansen is also Director and Chairman of Avance Gas Holding Ltd. He was educated at the Norwegian School of Economics (NHH) in Bergen.


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AltWeeklies Wire » News » LGBT
Body Image Affects Gay Men in a Queer Way
By Bill Stuart
Monday Magazine | August 12, 2004
Last year I was at a nightclub with a few pals, waiting for a band to play, when some loudmouth said, "That shirt is so gay!" to one of his friends. I decided to take him to task and asked what exactly does gay look like? Between myself (a husky, bearded guy wearing shorts and a T-shirt) and my two friends (one slimmer chap, fashionably wearing pretty much all black, the other a medium-build guy wearing jeans and a polo shirt), I asked him to identify which one of us was gay. The yahoo in question pretty much immediately pointed to my black-clad pal. After pointing out his error that it was I who was queer, I told him he needed to rethink his vocabulary choices.
It was a perfect example of how gay male body image is perceived by others. And a large part of the blame for this can be placed on advertisers who are trying to attract gay men by portraying buff, idealized bodies. You see them in magazine ads, on television programs and in films: gay men as 20-something gym bodies with perfect smiles. Of course, the fact is gay men—like people in general—come in all shapes and sizes.
"There is a broad range of desirable body types, yet only one type is used for advertising," says Gerry Kasten, a Masters student at the University of British Columbia. In his research, he is looking at the correlation between gay men's body image and the food choices they make. Flipping through a gay men's magazine such as Out, The Advocate or Xtra West proves Kasten's theory. It doesn't matter what a particular advertiser is selling, they use a buff gym body to draw in potential buyers. "Does a naked torso help me buy insurance?" Kasten asks. Maybe so, maybe not, but it's the age-old marketing technique of "sex sells."
However, physical attraction can only go so far. Though a certain advertisement may succeed with a portion of the gay community who do buy into this buff stereotype, there are definitely those who are not fooled. "[Advertisers] are guilty of not showing diversity," says queer community activist dean diamond. "It's a promoting of narrow viewpoints."
If you were to take a random sampling of gay men, you would find all sorts of body types—not just what Victoria doctor Doug McGhee calls the "anorexic nubile look" (men who are often referrred to as "twinks").
This body image stereotyping creates major problems, Kasten says. "The bodies depicted are difficult to achieve and very few men achieve [them]." If these images are repeatedly forced upon gay men, they will be attempting to work towards an improbable ideal. To achieve the stereotypical buff body, men are often putting their greater health at risk by choosing foods or fad diets or over-excercising. They do these things not to be healthy, but because they believe it is what will make them sexy and appealing to other men. Victoria resident Scott Wilson notes that, "In the gay community, there is often a greater sense of aesthetics and these images have more impact." As a result, gay men become the "object of their own desire." Not only are they trying to achieve this ideal body for themselves, but they are trying to achieve this body to attract a similar potential partner.
Some men who do achieve the ideal body, however, are only doing so on the outside. For example, says Kasten, some men who are HIV-positive are taking certain drugs, like protease inhibitors, which have a side effect of driving body fat from its usual storage under the skin and depositing it around organs, and testosterone, since their natural levels of this hormone are weakened. "The combination of these two things, along with the fact that some men work out strenuously [creates] a highly muscular, highly vascular appearance," Kasten says. "You get a highly prized body appearance in someone who's living with HIV disease and may or may not have an overall healthy life. I don't want to blow this out of proportion, but I think it's something that's noteworthy."
However, this "hypermasculinization" of gay male bodies is not a new thing. In the late 1970s, the "clone" look became popular, in reaction to the misconception that all gay men were skinny, effeminate queens. The look featured mustaches, checked shirts and jeans or leather pants. As Roger Edmonson describes in his 2000 book, Clone, the look and attitude was characterized by a "butch appearance, emotional withdrawal from sexual partners, and a view of sex as a contact sport." Think a combination of the leatherman, cowboy and construction worker from the Village People. In time, the clone look, too, became a caricature, and out of it grew the "bear" movement. Bears took the clone look further, by making it more natural, with full beards, husky physiques, hairy (that is, natural) bodies, and most importantly, jovial attitudes. Eventually, the bears, too, became stereotypical.
The aforementioned buff bodies now perceived as the gay male ideal are essentially the new clone in a new package, the next part of a vicious cycle that can ultimately affect gay men's mental health. "Marginalized groups are more vulnerable to eating and anxiety disorders," says McGhee. "I believe they are more vulnerable to influences that prey on their insecurities. I would imagine that they are more vulnerable to the negative impact of these images and therefore the impact on their eating disorders and anxiety disorders."
Certainly, not all gay men are unnecessarily suffering for the ideal body image. "You see it around, people who are active, trying to eat balanced meals and they are not jumping on any diet fad or looking for quick fixes in any way," McGhee says. "They are realizing that health doesn't come in a pill or a diet or surgical operation, but it's about relationships and activity."
Ultimately, the perfect male body image is as flat as the paper it's printed on.
Tags: gay & lesbian issues
Founded in 1975 to provide a critical voice in Victoria's political and cultural communities, Monday Magazine continues to shake British Columbia's conservative capital city with tell-it- like-it-is features and reviews. Targeting educated, active adults and Victoria's growing youth market, Monday...
Address: 818 Broughton St., Victoria, BC V8W 1E4
www.mondaymag.com
There Are More Pressing Issues Than Same-Sex Marriage for LGBT Communitynew
The LGBT political movement has become so impassioned by bourgeois equality values that it's turned its back on the needy of its own "community." AIDS claimed untold numbers of mentors, teachers, artists and role models, and current generations need to assume these roles.
New York Press | Charlie Vazquez | 01-09-2009 | LGBT
Tags: same-sex marriage, gay & lesbian issues
The Essence of Alison Bechdel's 'Dykes'new
Alison Bechdel's former assistant reflects on a quarter century of "Dykes to Watch Out For."
Seven Days | Cathy Resmer | 12-17-2008 | Cartoons
Tags: Books, lesbian, comics, Alison Bechdel, gay & lesbian issues, Dykes to Watch Out For
'Milk' Breathes Life into Counterculture Crusadernew
There is an inevitability to the tragedy of Milk, but the film never wallows in the downbeat. Instead, it gently celebrates the spirit of its indefatigable hero. More than just a martyr to the cause of gay rights, Milk was a leader who stepped up when troubled times demanded.
Weekly Alibi | Devin D. O'Leary | 12-09-2008 | Reviews
Tags: Gus Van Sant, Milk, gay & lesbian issues, Harvey Milk
California's Prop. 8 Defeat: A Bungled Campaignnew
The single biggest reason for the Proposition 8 loss was an ineffective and inept campaign strategy by the leadership of the No on 8 campaign.
Santa Barbara Independent | Terry Leftgoff | 12-08-2008 | LGBT
Tags: California, politics, same-sex marriage, gay & lesbian issues, Prop. 8
Young Gays Take Reins From Elders on Prop. 8new
In wake of gay-marriage ban, the mantle is shifting from battle-scarred AIDS warriors.
L.A. Weekly | Patrick Range McDonald | 12-01-2008 | LGBT
Tags: same-sex marriage, gay & lesbian issues, Prop. 8
More by Bill Stuart
Style Guys Colin McAllister & Justin Ryan Love Life in Canadanew
The stylish Scots duo made inroads into the interior-design world via various television series in the U.K. but made the leap over to Canada last year with the über-successful Home Heist show on HGTV, which has in turn been transformed into a new book, Colin & Justin's Home Heist Style Guide.
Monday Magazine | Bill Stuart | 09-18-2008 | Culture
Tags: Colin & Justin's Home Heist Style Guide, Colin McAllister, HGTV, Home Heist, Justin Ryan
Tape Headnew
Be Kind Rewind director Michel Gondry talks shop ... video shop, that is.
Monday Magazine | Bill Stuart | 02-20-2008 | Profiles & Interviews
Tags: Michel Gondry, Be Kind Rewind
Songwriter Applies His Breathtaking Prose to Fictionnew
This deftly written novel, part of a series of books by musicians, is an account of a confused, Smiths-loving teenager.
Monday Magazine | Bill Stuart | 08-07-2004 | Fiction
Tags: Morrissey, Smiths, Joe Pernice, Meat is Murder, Pernice, Fiction Reviews
More by Bill Stuart »
More by Monday Magazine
Anarchism Finds Comradesnew
Fifth annual Festival of Anarchy takes on Victoria's conservative image.
Monday Magazine | Danielle Pope | 09-27-2010 | Civil Liberties
Tags: Anarchy, Anarchism
New Habitsnew
Ex-heroin addict David Mitchell teaches people in recovery how to help themselves.
Monday Magazine | Danielle Pope | 09-27-2010 | Drugs
Tags: Addiction, David Mitchell, Heroin
Companion for Hirenew
One escort talks about the business of sex.
Monday Magazine | Danielle Pope | 09-27-2010 | Sex
Tags: Prostitution, Escort, Miss Emily Marie
Take Me to Tent Townnew
Despite the recent B.C. Supreme Court ruling, why is Victoria so scared to host a tent city when a growing number of U.S. centers let them stand?
Monday Magazine | Jason Youmans | 10-27-2008 | Crime & Justice
Tags: Canada, Homeless, law, Victoria, tent cities
The Children of Warnew
An international effort to get kids out of conflict has star power behind it, thanks to acclaimed musician Bruce Cockburn and senator Romeo Dallaire.
Monday Magazine | Amanda Farrell | 10-02-2008 | War
Tags: international, Roméo Dallaire, war & peace, Bruce Cockburn, Child Soldier Initiative, child soldiers
More by Monday Magazine »


Print An ensemble of 17 raw materials to recompose a deep Oud Wood enchanted by an Incense Rose signature. The most precious golds of the Perfumer's palette blend together to create a dark and leathery Oud accord, between spicy undertones of Cypriol.
Print A precious bottle made of glass and gold, adorned with a golden plate on the back to discover the imprint of the ingredients, and on the side, revealing the secret of the Assemblage.


Except for being three hours long, the new "Pearl Jam: Touring Band 2000" would fulfill the usual requirements for a live album.
Its 28 songs represent an overview of the band's U.S. tour, with presumably the best performances of each song culled from 19 different stops on the 48-show tour. That's fairly conventional for live albums.
But there's nothing conventional about the way Pearl Jam has been issuing its live material.
"Touring Band 2000," in fact, isn't a live album at all; it's a DVD (also out on VHS), with no audio soundtrack album in sight.
That's because Pearl Jam already released double live albums earlier this year from every show on its U.S. tour and nearly everything from Europe (apart from the deadly rock festival in Roskilde, Denmark, where nine fans were crushed).
Call it "Even Flow" in overflow, with 72 different albums released from the 2000 tour. That's 12 times as many studio albums as the band has issued in 10 years.
Although there are certainly a lot of variations among albums, most essentially repeat the similar set of songs in arrangements that hardly vary -- unlike, say, Phish or the Grateful Dead, whose live shows are heavily collected by fans because of the ever-changing nightly jams.
But why risk confusing fans (or bankrupting them) by releasing so many albums at once?
The flood of live albums isn't a ploy to cash in by Pearl Jam, who likely stalled its own career by challenging excessive TicketMaster charges years ago. Instead, the first wave of European recordings was announced as a way to provide fans an alternative to "high-priced, low-quality unofficial bootlegs."
The "official bootlegs," by contrast, come with a modest list price of $16.97 for the double-discs; even the triple-CD set that closes the series, "Live 11/6/2000 Seattle," has a list price under $20.
The packaging is spare, made to look like the smudgy rubber-stamp titles that came on the first plain-cover vinyl bootlegs in the '60s, such as the famous "Great White Wonder" of Bob Dylan.
But the sound is much sharper, with the soundboard recordings taken by regular Pearl Jam engineer Brett Eliason and mixed by associate John Burton.
Already the avalanche of albums has made some chart history.
When the first 25 albums were released last fall, five entered the Billboard Top 200 simultaneously. Not only was it the first time any act had more than one live album on the chart at the same time, it was the first time five titles from one artist made their debuts on the Billboard chart the same week (leading in sales were concerts in Katowice, Poland; Milan; Verona; London; and Hamburg).
Two more titles missed the chart by less than 1,000 copies -- Manchester, England, and Cardiff, Wales.
Pearl Jam broke its own record when 23 live albums from the first leg of the U.S. tour was released in February. That time, seven of the titles hit the charts simultaneously.
The only other bands ever to have seven albums on the chart were the Beatles, the Monkees and U2.
The final 24 albums were released in late March.
The simultaneous release has been problematic for retailers, many of whom haven't been able to find space for all 72 titles.
Modern-rock radio may have been built on songs by Pearl Jam; nevertheless, the stations have generally avoided playing anything from the live recordings, reverting to studio cuts when playing Pearl Jam.
Even the most diehard fan (the one who once imagined he'd buy every album Pearl Jam would ever put out) would pause at buying all 72 titles at a list price of more than $1,200 (though the band's initial deal at its website -- www.tenclub.net -- would have them paying more like $800).
So there's some furious activity in finding which albums are essential to buy.
First choice, for most, are those closest to home, where album buyers may have been in the audience.
(The Pearl Jam Binaural tour in 2000 didn't make it any closer than Jones Beach in Wantagh, N.Y., Aug. 23 to 25; the Saratoga Springs, N.Y., Performing Arts Center, Aug. 27; and the Tweeter Center in Mansfield, Mass., Aug. 29 and 30).
Otherwise, the easy choice is the final night of the tour in the band's Seattle hometown on Nov. 6, 2000 -- the only show to require three discs. Its 29 songs include two Who covers, "The Kids are Alright" and "Baba O'Reilly."
"10/22/00, Las Vegas" -- where the band marked its 10th anniversary.
"8/25/00 Jones Beach" -- where the band's "No Code" album seemed to be especially emphasized.
"9/5/00, Pittsburgh" -- the last show before a monthlong break.
"6/22/00, Milan" -- one of the highest-ranking European recordings, thanks mostly to the unnaturally involved audience, singing along lustily to nearly everything.
"6/16/00, Katowice, Poland" -- which was, conversely, an unusually mellow show before about 1,000, who had been shut out of the oversold show the night before.
In presenting such a wealth of material, Pearl Jam inadvertently shows how important bootleg recordings are to fans.
Hardly any of the shows that are highly rated for fans are represented in what seem to be the band's official overview on the "Touring Band 2000" DVD.


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Report finds gaps in Delaware prison health care system
Health_Medical_Pharma
Claire Dematteis
By RANDALL CHASE - Associated Press - Thursday, December 5, 2019
DOVER, Del. (AP) - The head of Delaware's prison system insisted Thursday that inmates are getting good medical care, but a new report indicates the correction department's health care system is plagued by poor communic ations, little accountability and a lack of data collection and analysis.
The independent review of medical and behavioral health care in state prisons found that "functional governance" and "shared accountability" extending from Department of Correction leadership to prison facilities was "minimally apparent."
Reviewers also said they found no documents that articulated goals for health care delivery within the department, and no evidence of meaningful collaboration between DOC's health care bureau and its medical contractor, Connections Community Support Programs. Organizational changes are needed to ensure both quality improvement and process improvement, reviewers said.
"A culture of reporting, learning, and improving deviations in operational and care process was not present," the 16-page report stated.
The review was conducted in September and October by 15 staff members of Christiana Care Health System, Delaware's largest hospital system, who visited seven DOC facilities.
DOC Commissioner Claire DeMatteis said the report provides a road map on how to improve health care delivery to inmates, and that the suggested improvements represent "a manageable challenge."
"We need to update how we do business in delivering health care," DeMatteis said. "We used to do much more auditing of our health care vendor and our outcomes and our patients' safety and quality, and we have to ge t back to that."
DeMatteis was appointed DOC commissioner in June after overseeing efforts to implement recommendations contained in a report on a deadly riot at Delaware's maximum-security prison in February 2017.
"I am confident that offenders are getting good health care in our correctional facilities," she said. "What this report will do is help us make that better and hold our vendor accountable and hold us accountable to key quality assurance measures."
DeMatteis said that, other than fixing the DOC's electronic health record system, none of the recommendations in the report would require additional spending. The cost of fixing the 5-year-old system has been estimated at between $3 million and $5 million, she said.
Stephen Hampton, an attorney who has represented several inmates in lawsuits alleging inadequate medical care, said the report points out problems that have existed for years.
"However, despite general recommendations about needed improvements to the correctional health care system, there is no specific advice on how to solve the problems," he said. "Unless the Department of Correction promptly addresses these problems with a specific plan on remedying them, the report will have been of no consequence."
Christiana's report did not review compliance with industry or regulatory standards, or disease-specific protocols, instead focusing more on organizational and administrative issues.
DOC's medical director, Dr. Awele Maduka-Ezeh, said the biggest health care challenge for the department, from a clinical perspective, is substance abuse disorders. As of last week, more than 940 inmates had received medication-assisted treatment for substance abuse disorders this year.
Earlier this year, Delaware lawmakers unanimously approved a bill reforming a committee charged with monitoring prison health care. The bill was introduced after the attorney general's office confirmed that it was investigating allegations that Connections had ordered staffers to forge documents to falsely state inmates were getting mental health treatment they never received.
DeMatteis said she was told office last week that the investigation is continuing. Connections' current contract with DOC expires June 30.
Copyright © 2020 The Washington Times, LLC.


Yangbanxi, (Chinese: "model drama") Wade-Giles yang-pan-hsi, form of Chinese entertainment that flourished during the Cultural Revolution (1966–76). The works combined elements of traditional Chinese dramas, particularly jingxi (Beijing opera or Peking opera), with modern Western drama to treat contemporary topics and feature proletarian protagonists. The yangbanxi are known as the "eight model works." They include five jingxi: Hongdengji (performed 1964; "The Story of Red Lantern"), Zhiqu weihushan (performed 1964; "Taking Tiger Mountain by Strategy"), Shajiabang (performed 1965; "Shajia Village"), Haigang (performed 1964; "On the Docks"), and Qixi baihutuan (performed 1964; "Raid on the White Tiger Regiment"); two ballets, Hongse niangzijun (performed 1964; "The Red Detachment of Women") and Baimao nü (performed 1965; "The White-Haired Girl"); and a symphony, Shajiabang (composed and performed 1965), based on the jingxi of that name. Later examples following these models were known as yangban zuopin ("model works"). The plays were later filmed in Technicolor, and beginning in the 1990s some of them were revived for the stage in Beijing, Shanghai, and other cities. Many songs from this genre remained popular in the 21st century.