Improving your memory does far more than helping you remember small details. In fact, finding ways to improve your memory can also increase your productivity throughout your work days tremendously. Through these online video tutorials, you will learn about the key functions of the brain involved in the memory process. Additionally, this course covers the kinds of nutrients needed to keep your memory functioning at peak conditions.


Scientists from Lancaster University have discovered that immune responses originally found to prevent fungal infections are also important in eliminating Trichinella spiralis, a round worm and the causative agent of Trichinosis. People acquire trichinellosis by consuming raw or undercooked meat infected with the Trichinella parasite, particularly wild game meat or pork.
New findings published today in Science Advances, detail three-dimensional imaging research by a group of scientists at The University of Manchester and St Mary's Hospital. The research has opened up understanding about this vital life-sustaining process by mathematically modelling the human placenta.
To improve the treatment of children with irritable bowel syndrome (IBS), investigators have developed a sophisticated way to analyze the microbial and metabolic contents of the gut. A report in The Journal of Molecular Diagnostics, published by Elsevier, describes how a new battery of tests enables researchers to distinguish patients with IBS from healthy children and identifies correlations between certain microbes and metabolites with abdominal pain. With this information, doctors envision tailoring nutritional and targeted therapies that address a child's specific gastrointestinal problems.
Contamination of rice with arsenic is a major problem in some regions of the world with high rice consumption. Now, researchers reporting in the ACS journal Environmental Science & Technology have found a way to reduce inorganic arsenic in rice by modifying processing methods at traditional, small-scale parboiling plants in Bangladesh. The new method has the added benefit of increasing the calcium content of rice, the researchers say.
Milk is a staple of the human diet, full of key nutrients such as protein, carbohydrates, fats, and vitamins. Cow's milk in particular is one of the most-used dairy products globally, with over 800 million tons produced annually according to the United Nations Food and Agriculture Organization. Today, scientists report in ACS' Journal of Agricultural and Food Chemistry a comprehensive, centralized database of all known bovine milk compounds.
Scientists at the University of Illinois developed new purple corn hybrids with differing combinations of phenols in the pericarp that fight obesity, inflammation and insulin resistance, a new study in mice suggests. The pericarp also provides the food industry with a new source of colorants and farmers with a new value added product for their crops.


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Marvel Snap players can compete with friends starting tomorrow
Home/Business/Elon Musk seeks to sell Twitter shares in search of new funds
Elon Musk seeks to sell Twitter shares in search of new funds
The head of Elon Musk's family office has approached investors who helped the billionaire buy Twitter for $44 billion in October in an attempt to raise new money as the social media company continues to bleed cash and faces heavy interest payments on its debts.
Jared Birchall, a former Morgan Stanley banker, approached Twitter shareholders on Thursday afternoon, according to two people familiar with the matter. He offered new shares of the company at $54.20 – the same price Musk paid to take the company private.
Its note to investors, first reported by Semafor, said Twitter was "pleased to announce a follow-on equity offering for common stock at the original price and terms," according to a person who received it.
The memo didn't specify how much Twitter planned to raise in the new fundraising effort, but said it aimed to wrap up the fundraiser by the end of the year.
"It was all haphazard and crude," said investment adviser Ross Gerber, who invested in the Twitter deal in October and confirmed he had received the latest offer. "They do it because they have no more money. I do not think so [Musk] I expected such a big drop in income.
A second person whose company received the offer said Musk indicated the new capital would be used to fund an expansion of his business, including a 'round of hires' of programmers to create a 'great app' which could process payments, among other services.
Birchal and Musk planned to hold a series of calls with Twitter investors who want to increase their stake in the company, the person said.
Musk bought Twitter after a dramatic six-month legal row, financing the acquisition with about $13 billion in debt and outside equity of about $7 billion.
But it has been scrambling to cut costs since then, including laying off around half of Twitter's staff, after advertisers fled the platform over concerns about its content moderation strategy, threatening its advertising business. $5 billion a year.
A number of high-profile investors have written big checks to help fund Musk's takeover on Twitter in exchange for stakes, including Sequoia Capital, Andreessen Horowitz, Oracle co-founder Larry Ellison and the exchange of Binance cryptocurrency.
Banks such as Morgan Stanley, Bank of America and Barclays face significant losses on the financial package they provided. Twitter, which made a loss of about $221 million in 2021, must pay annual interest of about $1 billion on the loan.
Between Monday and Wednesday, Musk sold $3.6 billion in You're here, the electric vehicle manufacturer he founded and directs. It was his fourth sale of Tesla stock this year, bringing his total disposals to nearly $40 billion.
The sales took place despite Musk saying there would be "no further TSLA sales" to support the Twitter deal in April.
On Tuesday, Musk tweeted, "At the risk of stating the obvious, beware of debt in turbulent macro conditions, especially when the Fed continues to hike rates."
The banks that underwrote Twitter's buyout debt are desperate to sell the subprime loans to credit investors and get them off their balance sheets. However, large discounts demanded by investors would result in losses that could easily exceed $1 billion, people with knowledge of the matter told the Financial Times.
Musk could not be reached for comment on Friday. Twitter did not respond to a request for comment.
Additional reporting by Hannah Murphy and Ortenca Aliaj
How Uber's price spike explains the Fed's lack of inflation
G-7 joins EU on $60 a barrel price cap for Russian oil
Shares of ant-related companies rise after news of Jack Mac's divestment; Alibaba jumps
Sony and Honda unveil Afeela, Bird Buddy debuts new smart charger, and Amazon secures $8 billion loan • TechCrunch
Sam Bankman-Fried to Argue in FTX Fraud Case

redpajama_set_name: RedPajamaCommonCrawl


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01 Aug 2016 / by ScottHulse / in Government Regulation & Compliance, Labor & Employment, Legal Updates
Effective Today, the Cost of U.S. Department of Labor Fines and Penalties Is Increasing Significantly
By Rosemary M. Marin, Attorney & Shareholder; Chair, Labor & Employment
Effective today, August 1, pursuant to the Inflation Adjustment Act that was passed by Congress in November, 2015, and with a pair of Final Rules that were finalized on July 1, 2016, the U.S. Department of Labor (DOL) is implementing substantial, double-digit price increases for fines and penalties to keep up with inflation. These are the first increases in more than two decades.
For example, under the Occupational Safety and Health Administration (OSHA), the maximum fines are rising by 80%, from $7,000 to $12,600 for each serious violation; and from $70,000 to $126,000 for each willful violation. Similarly, under the Fair Labor Standards Act (FLSA), the maximum fines are increasing more than 70%, from $1,100 to $1,894, for each violation. Under the Immigration Reform and Control Act (IRCA), the maximum fines will rise 45%, from $35,000 to $50,800, for willfully displacing a U.S. worker with an H1B visa holder. A complete, downloadable PDF list of all penalty adjustments is available at:
https://www.dol.gov/sites/default/files/2016-inflation-penalty-chart.pdf.
DOL-related claims were already on an upward swing, but with recoverable penalties increasing substantially, Plaintiffs' attorneys now have an even stronger incentive to bring individual and collective actions.
The new DOL Final Rule on so-called White Collar Exemptions will take effect on December 1, 2016 and is expected to affect approximately 4 million American workers. Additionally, health and welfare benefit plan audits are on the rise. Now is the time for all employers, both large and small, to audit their overall practices, policies and training and take swift action to ensure compliance with the various DOL-related laws.
If you need assistance in strategizing and implementing necessary changes, please call our Labor & Employment legal team at ScottHulse, P.C. We are armed to tackle tough issues and ready to assist.
Francisco Ortega
Attorney / Shareholder
James Feuille
M. Blake Downey
Javier Macias
PASS IT ON If you know someone who would benefit from this information please share it.
Tags: Labor & Employment, Legal Updates


Welcome and introduction by To be announced. to the topic of Blockchain Technology - Fostering Self-Determination and Autonomy?
I. Registration — Note that registration is necessary.
VIII. Break — Note that we will gather questions for panel discussion.
a monthly discussion series to foster a factual debate about Crypto-Currencies, Blockchain Technology, and Smart Contracts.
The aim of BlockChain Nights is to bring together students, researchers, and start-ups from Berlin's venture scene. The inter-disciplinary series addresses all interested in business, economics, or technology perspectives – theorists as well as practitioners.
Despite careful checking prior to linking, no responsibility for external links can be assumed.


It was a thrill to bring magic and smiles to the families at the Starkey Hearing Foundation's hearing aid distribution event this summer. Around 150 children received hearing aids at the Starkey Event.
I love to see the smiles on the children's faces as they react to the comedy and magic. It is all very visual so they like it, but it was fun to see some of the kids as they came out with a new hearing aid and how they commented on what they were able to hear. That's real magic!
This is a great organization with wonderful work giving out hearing aids in countries all over the world.
I'd like to thank the nice folks at the Starkey Foundation for inviting me to the spend the day doing magic with the families at the distribution, it was a joy.
I'm also grateful that the team at the Foundation saw my magic and enjoyed it and invited me to return two nights later to do strolling magic and comedy at their special event for the visiting audiologists. I met some very sweet people from all over the US who came into town for the big Sunday benefit gala. That night Elton John, Billy Chrystal and many others rocked the Exel Center and raised over $4.6 Million.
The Starkey Foundation does such a great work to help kids all over the world hear.
I recently had the pleasure to perform again with Sheila Raye Charles. Sheila is a very gifted and dynamic singer. The audience was thrilled by her original music as well as the songs of her father Ray Charles. Sheila also shared her difficult yet awesome life story.
This was the second time I got to enjoy her wonderful music and be her opening act with my comedy magic. We are looking forward to more events like this.
My sweet wife and I just celebrated our 27th Anniversary and I was reflecting on how humor is such a vital part of any relationship.
Researchers have proven the value of humor in the workplace. It is an important asset to successful teambuilding and customer service. Anyone who is married more than 7 months probably realizes the helpful effects of humor in their relationship.
In the dating stage of the relationship almost everyone says that they adored their companion's sense of humor. But after being married I discovered how vital that humor is to a healthy balanced relationship. We need humor to help us over the rough spots in life. If we can laugh at our slipups, mistakes, blunders and just plain bad choices, we are on the path to forgiveness and understanding.
My sweetheart works in a bank. Once she brought a small gag gift, hand held device to her office that emits a small spray of sparks. It is like a joy buzzer that shoots sparks off a wind up flywheel. This was the day the computer guy came to do check ups. Before he came she surprised each of her co-workers with this same device. Finally the computer guy arrives and after he tools around a bit she says, "Well there is one other thing about this computer, whenever I touch this button…" She lightly touches the number 7 on her computer keyboard and at the same time lets the sparks fly. The guy about does a double back flip, "shut it down – where's the power supply!!!…" Everyone else who had been tricked by this device earlier got to enjoy seeing the computer expert encounter a very unique problem. When he realized he had been tricked, he was the best sport of all and he laughed like crazy. He probably still tells his friends about that crazy woman at the bank.
We all need a bit of humor to spark up our day. Humor helps us realize we are simply human. We have troubles and challenges but laughter brings joy to our lives. It mixes things up and brightens our day. Go spread some humor.


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Great idea, wish I'd discovered these sooner!
Excellent practical product. I would highly recommend!
Fantastic idea for school water bottles, makes the school run easier and stops any soggy bag mess.
Very good quality and perfect for the job. Thank you.
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A simple yet great product and excellent customer service.
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Other Travelers
Hornit Bike Horn
Mavic EX721 Rim
SteriPEN Ultra Water Purifier
Kyrgyz Beachtime
I'm not sure there is anything gloomier than rain while staying at a budget hotel in a small Kyrgyz town. The hotel in Kochkor: no running water, a bathroom consisting of a shack in the back of the hotel and a grumpy attendant who turned her radio on full blast at 6a.m. (I suspect to piss us off). We had a few sad encounters with heavily intoxicated men wandering the rainy streets, but we mainly rested in our hotel until the rain finally subsided 2 days later. For the next three days we stayed in Cholpon Ata, a town on the north shore of Issyk Kul Lake. Cholpon Ata isn't a backpacker destination, it's a everyone else in Kyrgyzstan destination. It's a beach resort, summer party town, packed to the brim with vacationing Kazakhs, Russians and city folk. When we arrived in town, the sun was shining and the beach blow up toys were out, we joined the crowds of people streaming towards the beach. The road to the beach is lined with shops selling, well, mostly alcohol, but also sea shells (there are no sea shells at Issyk Kul Lake), smoked fish, samosas, beach toys, bathing suits... The beach was totally packed but we were so happy to get some sun. On our second day in Cholpon Ata, we went to the beach again but spent the afternoon on an educational excursion to the local petroglyphs. The outdoor 'museum' consists of a giant pile of rocks scattered across a few kilometers. The first few petroglyphs are indicated by small signs, but I suppose funding ran out, and for the rest of them you're on your own. We didn't manage to find too many but had fun in our attempt "Yann, Yann here's one... oh no wait... it's just a another rock". In the evening we feasted on outstanding local smoked fish, cheese, bread and a bottle of Moldovian wine (not so outstanding). After two days, we had to move on, but Yann REALLY liked the beach, neither of us had seen that much skin in a long long time. There was possibly a little bit too much of it, although it was refreshing to see the GIANT bikini clad Russian babushkas being lathered with sun screen by their hairy speedo wearing husbands. Some of the more hilarious Kyrgyz beach activities included being photographed with a large boa, riding a camel or my favourite (and most common): getting really sunburned and drunk. We followed the north shore of the lake until we got to the old Russian outpost of Karakol. We arrived in the pouring rain, were rejected (in Russian) from the cheapest hotel in our book, so we settled for a more upscale backpacker hangout (second cheapest). It was a lovely old colonial home, run by little Babalina an old Russian matriarch. We had scheduled three days in Karakol, but we managed to visit its main sights in, hmm let's see, 45 minutes. This included the Russian Orthodox Cathedral, the Dungan Mosque, the regional museum and a bunch of statues of guys we didn't recognize (except for Lenin of course). Despite an unrivalled collection of stuffed animals at the regional museum, the highlight of Karakol had to be Zarina's Cafe, the local cafe around the corner from our guesthouse, in particular its 'pelmeni in a pot'. Pelmenis are little raviolis stuffed with meat, 'pelmeni in a pot' is a pot full of pelmenis doused in garlic, sour cream and cheese then baked in an oven. Pelmenis pretty much kept us in Karakol longer than was necessary.
Country: Kyrgyzstan Posted on Thursday, August 30, 2007 2 comments:
July in Kyrgyzstan's Summer Pastures
Along with Margo and Dave, we organized a taxi to Song Kol Lake. About 150km from Naryn, in Central Kyrgyzstan, it is a favourite spot for herders and shepherds. They transport their livestock along with their yurts and set up camp for the summer months while their herds enjoy the lush, green mountains. It also seems to be a favourite spot for travellers, who like the idea of spending time in a yurt surrounded by beautiful scenery. We avoided organizing anything in town (overpriced), assuming that we would easily find a place to stay once we arrived at the lake. This turned out to be a wise decision, with yurts scattered all over the hills. We were carrying our full packs, so the walk to the yurts that we had spotted in the distance seemed to take longer than we had hoped. A young horseman came to greet us and quietly walked along side us as we trekked along. We happened to have picked a yurt affiliated with tour groups, so they wanted to charge us some ridiculous amount for a place to sleep on the yurt floor. After some discussion we got the price down. Dave had his own tent, so Margo, Yann and I shared the floor of a big empty yurt. The rest of the day consisted of lying outside in the sun. We were offered a dinner of fried fish (fresh from the lake) and boiled potatoes for about 0.50$ which we obviously did not turn down. We coated the boiled potatoes with thick fresh cream, straight from the cows, or maybe from the goats. This was what we had come for, the quiet, solitary, outdoor summer life of the Kyrgyz shepherds. We spent two nights in the yurt, not really doing much during the day. We watched the daily activities: killing and gutting a sheep, drying yogurt balls, salting sheep hides, drinking tea (and vodka) and bringing in the sheep at sunset. Margo and I attempted to swim in the freezing lake, Margo made it in, I made it up to my waist (we now understood why the kids wouldn't come swimming with us). In the afternoon scary storm clouds started creeping over the mountains, and it rained all evening and all night. The yurt is coated with sheep fat for waterproofing and there were only a few leaks, so we managed to sleep despite the cold and rain. On the next morning we loaded up our bags and began our walk along the south shore of the lake. We were trying to get to the main road so that we could hitch a ride back to town (at a reasonable price). Unfortunately, there is not a lot of traffic to and from the lake, and if you are pressed for time it's easy to be held hostage by the locals who attempt to charge about 100$ for the ride into town. It had been quite a while since we had done any serious walking, and after about three hours I was getting pretty grumpy (because I am lazy). We made it to another yurt camp just as rain started pouring down. We were greeted by Toumcul, a sweet 14 year-old girl who spoke some English and seemed to be running the camp along with her two younger sisters (12 and 5 years old). In the afternoon we got a visit in our tent from Isbek, a big, drunk Kyrgyz man with an unopened bottle of vodka to share with us. Margo and I attempted to turn down the shot glasses, but Isbek would have nothing of it. Thus began the toasting to "Kyrgyzstan OY!", "Canada and Golandia" (note, Golandia is the Kyrgyz word for Holland, which we attempted to correct for about an hour before giving up and toasting to Golandia ourselves). Yann carried the weight for both Margo and I and drank Isbek under the table (in all fairness, Isbek was pretty hammered to begin with). After one bottle was finished, Isbek called for more to be brought in, I hid them under the sheets of my bed, Isbek fell asleep at the table and was escorted to bed. For dinner, fried fish was on the menu once again. I was sad to find the three sisters sitting on the floor of their trailer preparing our dinner. After serving us they also fed and brought in the animals. I watched the youngest girl, Meerim, struggle to the trailer with a heavy kettle of water. The only time we saw any adults was the next day when they came to collect the money from us. Once she was a little bit relaxed, Meerim was glued to us. She spent all evening in our yurt playing with Yann who granted her all the attention that she desired. The two older girls continued with chores (although we did get a singing concert from the three of them, complete with dance routines, beyond adorable). The next morning, cheerful Isbek, now sober, wasn't so cheerful when we started trying to negotiate prices for a drive into town (it was still pouring rain). We got him down to half his initial offer, which was still way to high. We raced down from the mountains to the sound of Isbek's cries of "Kyrgyzstan OY!" everytime he rammed too hard into pot holes.
Country: Kyrgyzstan Posted on Wednesday, August 22, 2007 2 comments:
Over the Torugart Pass
Central Asia was our initial inspiration for travel, it seemed like a place that no one really knew about, or travelled through. It took us almost nine months of travel before we arrived in in Kashgar and started making arrangements for the trip across the border to Kyrgyzstan. We had two options, one by public bus, across the Irkeshtam and the other by private vehicle across the Torugart Pass. Neither option was particularly appealing to us, the first pass would bring us to Southern Kyrgyzstan, not where we wanted to be, and the second option was too expensive. It's only expensive because the Chinese keep it that way, by classifying the border as 'Class 2' which means only locals can cross it. For foreigners to be allowed to cross they must first get a permit and have transportation arranged on both the Chinese and Kyrgyz side. Our guidebook had quoted the trip as costing 100-200 USD per person, which was way way too much for us. There is only one travel agency that organizes transportation and we managed to get a taxi all the way across the pass for 75 USD per person (provided we could find two others with whom to share the taxi). After hanging around Kashgar for about a week, we paired up again with Margo (who we travelled with in Pakistan), and an Australian guy named Dave and made arrangements to cross the pass.
Yann had predicted that our vehicle would be the smallest possible that could fit the four of us (plus guide and driver), when we arrived at the parking lot for pick up we were greeted by an actual bus, and two older Austrian travellers. They had paid premium price for a tour bus, and we were added in (much to our satisfaction). So our transportation on the Chinese side was alot better than Yann had guessed, 6 people in a bus that fit 18. Part of what is attractive about the Torugart Pass is its isolation, the bureaucracy involved in its crossing and the fact that not many people make the trip. For us, it was all just a little bit too easy, we expected our ride on the Kyrgyz side not to show up, or to attempt to charge us more than we had agreed to, or the Chinese border guards to deny us permission to cross. The only thing that made the trip difficult was the fact that our Kyrgyz driver had removed all the handles from his car doors, so that no one could roll down the windows (he didn't want the dust coming in), so we sat smooshed together, sweating and breathing in the exhaust fumes that I suspect were leaking into the car from somewhere. Our driver seemed to be 'in' with the border guards and we whizzed through the eerily deserted checkpoints, our bags never even leaving the trunk of the car. Other than the drive through vast seemingly uninhabited territory, our first taste of Kyrgyzstan was the town of Naryn. It's hard to describe how different Naryn felt from any of the other towns we had visited in the past months. We hadn't really prepared ourselves for the Russian influence in Central Asia, or maybe we weren't really aware of its extent. Our hotel was a decrepid Soviet dinosaur with our room door not locking (but cheap, 1.50$ per bed). For lunch we found a cafe and ate borscht while drinking beer on tap. The streets were lined with mature trees and old Russian cars ran slowly back and forth down Lenina street. Most store shelves were stocked with dozens of different kinds of vodka, all sadly selling for not too much more than bottled water. Men exited cafes mid-afternoon carrying the smell of alcohol along with them. While women and young red-cheeked children sat at street stalls selling produce or homemade bread out of baby carriages. The coordinator of the local tourist office proudly exclaimed that Naryn was 99% Kyrgyz, although to us, it didn't seem like the local customs were 99% Kyrgyz.
Country: China, Kyrgyzstan, Xinjiang Posted on Sunday, August 19, 2007 4 comments:
Best (and Worst) of Pakistan and the Karakoram Highway
Here we have some of our best and worst moments of our 28 days in Pakistan and the Karakorum Highway (to Kashgar China), we've also put together a gallery of our favourite photos which you can visit if you don't feel like ploughing through our other gazillion photos. The gallery is available here.
Our FAVOURITE Cities/Towns
According to Yann:
1- Karimabad (Hunza Valley)
2- Passu (Gojal Valley)
3- Gilgit
According to Emilie:
1- Karimabad
2- Lahore
Our FAVOURITE Activities
1- Suf Night in Lahore
2- Shandur Polo Festival
3- Afternoon naps in Karimabad
4- Livestock market in Kashgar
2- Sufi Night in Lahore
4- Visit to the Baltit Fort in Karimabad
Honourable Mention: Visiting with locals on Gilgit's main bazaar
WORST Experiences
1- Wondering why the hell we were in Skardu
2- 20 hour bus ride from Rawalpindi to Gilgit
3- Late night hotel search in Rawalpindi
3- Being violently ill in Karimabad
Most DELICIOUS Foods
1- Burutz berikutz: chapatis stuffed with mint, spring onions and Hunza cheese (burutz)
2- Chicken shawarmas in Lahore
3- Chicken kebabs and fresh naans out of the tandoor
1- Burutz berikutz, cheesy goodness!
2- Chap shuros (Hunza meat pies, or "Hunza pizzas")
3- Walnut cake from the "Cafe de Hunza"
Note: You might have noticed we enjoyed Hunza cuisine. Here is an EXCELLENT free cookbook with traditional Hunzan dishes, try some, you will not be disappointed!
BEST Scenery
1- Karakorum and Pamir Ranges on the Karakorum Highway (Chinese Side)
2- Passu's jagged mountains
3- Karimabad snowcaps
2- View of Baltit Fort and surrounding 7000m+ peaks
3- Passu
Honourable Mention: Around Shandur Pass
MOST Difficult things about Pakistan travel
According to Yann and Emilie:
1- Hospitality: having to turn down so frequently friendly offers of free tea, food, beds to sleep in...
2- Big city pollution (Lahore! and Rawalpindi)
3- Making sure not to make a social blunder (especially for the ladies)
Things that SURPRISED us about Pakistan
- Incredible hospitality
- Almost complete absence of women in the streets and public places
- So many languages (a different one in every valley), less than 10% of Pakistanis have Urdu (the national language) as their mother tongue
- People in Hunza don't like shaggy Taliban-esque beards
- Only men dance in Pakistan (but that doesn't stop them from trying to get foreign women to dance)
- It's the second place I got a can of ginger ale in 9 months (at the Lahore "imports" grocery store, I love you Lahore "imports" grocery store)
- Red hair and freckles
For those interested in our expenses, we have updated our homepage with our financial information for Pakistan and the Karakoram Highway, it is available here
Country: China, Pakistan Posted on Friday, August 17, 2007 3 comments:
Best (and Worst) of India
Here we have some of our best and worst moments of our 87 days in India, we've also put together a gallery of our favourite photos which you can visit if you don't feel like ploughing through our gazillion photos. The gallery is available here.
Our FAVOURITE Towns/Cities
1- Darjeeling
2- Kolkata
3- Leh
Our FAVOURITE "Tourist" Activities
1- Being the day's first viewers of the Taj Mahal
2- Jama Masjid at Fatehpur Sikri
3- Jasailmer Fort
1- Taj Mahal
2- Sunrise boat trip on the Ganges at Varanasi
3- Merangarh Fort audio tour in Jodhpur
4- Golden Temple in Amritsar
Most DISAPPONTING Places/Activities
According to both Yann and Emilie:
1- Jasailmer camel "safari" (noting that it was too hot and Emilie was too sick to be doing it)
2- Bollywood movie in Jaipur, where's the choreographed dancing? (we weren't disappointed with the venue though, the Raj Mandir Theatre)
3- McLeod Ganj, as one blogger referred to it: Tibetan Disneyland
"CHEAP and BEST" Food
1- Varanasi thalis (rich, buttery, all-you-can-eat and dirt cheap)
2- Kolkatan street food
3- Agra "tourist breakfasts" (15 rupees for eggs, toast and jam, fruit and COFFEE)
Our FAVOURITE Dishes
1- Paneer butter masala (chunks of cheese swimming in rich creamy curry sauce)
2- Palak paneer (more cheese this time with spinach)
3- Samosa chaat (pieces of samosa covered with tomato sauce, curd, herbs and other delicious things)
4- Masala dosas (large flat pancakey things wrapped up and filled with veggies or cheese or whatever)
1- Samosa chaat
2- Fresh warm chapatis dipped in curry gravy
3- Paneer butter masala
4- Fresh curd and local fruits
1- Varanasi ghats
2- Morning puja at Ladakhi monasteries
3- Golden Temple, Amritsar
1- Tso-Moriri Lake
2- Himalayas from Sikkim villages
3- Darjeeling: mountains and tea plantations
MOST Challenging Experiences
1- Trying to keep Emilie from losing it
2- The heat in Rajasthan and Delhi
3- Uncomfortable long distance bus travel
1- The 50+ degree heat in Delhi
2- Recurring bouts of traveller's diarrhea
3- Local perception of Western females
Things that made us the MOST Uncomfortable/Annoyed
1- Non-stop approaches from touts/scammers
2- Annoying hippy types
3- Cows and stray dogs in the streets (but the cows make a way bigger mess)
HIGHEST Concentration of Annoying Hippy Types
1- Varanasi
2- Delhi (Pahar Ganj)
3- Pushkar
For those interested in our expenses, we have updated our homepage with our financial information for India (less than 2500$ CN in 3 months, not too shabby?), it is available here
Country: India Posted on Tuesday, August 14, 2007 3 comments:
Kashgar Markets
Even though Kashgar is mainly an Uyghur city and retains more of a Central Asian feel, the Han Chinese influence is inescapable. We were definetely back in China: neon lights, wide streets, big ugly concrete tile-covered buildings and the best of all NO English! Kashgar would be considered a conservative town by Chinese standards, but compared to Pakistan it felt like we were in Las Vegas. Yann nearly lost his head when a tourist in a short skirt and a tank top passed us in the hotel. Most of Kashgar's Uyghur women where a long skirt and a kerchief over their head, quite conservative, but unlike in Pakistan they ride motorbikes, yell at their husbands in public, work at restaurants and talk to men. Most Uyghur men wear the Han Chinese dress pants, shiny dress shoes and polo shirt but are distinguishable from the Han by the wearing of one of many different styles of Uyghur hats. For a glimpse into the Uyghur community we visited the Old City and the central mosque. We spent our lunch times in local restaurants, Yann devouring the sheep liver kebabs and me mostly sticking to the thick naan bread and nutmeg tea (neither of us sampled the non-alcoholic brew, cavas). For dinner we couldn't resist the cheap Chinese eateries complete with cheaper-than-water beer. Kashgar is famous as a Central Asian crossroads, on the ancient silk route, it sits on the road linking China to Kyrgystan, Tajikistan, Pakistan, Kazakhstan and Tibet. It's Sunday Market is a major tourist draw, although we were a little bit disappointed by it. I'm not sure exactly what we expected but the hardware section was particularly uninspiring. There were a few quirkier stalls, like the Chinese medicine men (always good for a few minutes of entertainment), but the cheap Chinese made goods far outnumbered anything interesting being sold. The livestock market on the outskirts of town was considerably more exciting, with hundreds of sheep, horses, donkeys being sold and traded. Around the market, dozens of stalls cooked up mutton kebabs, noodles and other 'treats'. The livestock market is a man's world, with young boys proudly herding around goats on leashes, or guarding the family donkey cart. We watched the large scale sheep shearing and Yann spotted an old man inspecting a sheep's health (read: sticking his fingers up the sheep's butt). There are quite a few tourists around and Yann and I certainly didn't blend in with the scenery. Yann was almost run over by a speeding donkey cart and I perhaps got a little too much 'into' photographing the wild male donkey who ripped himself free from his chord and jumped onto his female neighbour (his handlers couldn't control him, they were actually pelting him in the head with large rocks and he didn't ever lose focus). The livestock market seemed like a trip back in time and we soaked up the Uyghur atmosphere, getting lost in a sea of white skull caps, dust and animals.
Country: China, Xinjiang Posted on Saturday, August 11, 2007 1 comment:
Leaving Pakistan
After the detour to the polo festival, we had to race back north and ended up with only one night in the beautiful village of Passu about an hour past the Hunza Valley. The village is squeezed between two giant glaciers and surrounded by jagged mountains which have over the years contributed to its stagnant size. Passu is an Ismaili community and we arrived on the eve of the Aga Khan Golden Jubilee. Villagers were decorating their storefronts with the green and red flags of the Ismailis, kids roared around the village and the local town hall was bursting with activity. With our day in Passu we planned on doing a small trek, taking in other local villages and crossing over two death-defying suspension bridges (well, they SEEM death defying). The trek is aptly named the "two bridges walk" and was supposed to take about 5-6 hours. We set off with Derek, an American, and turned the two bridges walk into the one bridge walk, covering about 6km in 5 hours, what a team! The bridge that we did manage to find is really an incredible sight, it's long, it's falling apart, and it's used by locals to move between their village and the pastures across the river where they keep their animals. All three of us felt that we should make the trip across the bridge and back, I was the only one who was unable to do so. With my short limbs I could barely stretch my arms out wide enough to grip on to the two cables that would keep me standing, so I turned back after a few feet. Yann, Mr. Vertigo, didn't heed my warnings and took a really really long time to make the trip. The bridge is made up of old broken wood planks that are joined together unevenly by wire cables. It's impossible to do the walk without watching where you step, but then you are faced with the swirling, raging river below you, which basically makes you want to puke. By the time we got back to Passu we were tired, thirsty and sunburned. I had worn a t-shirt for the first time in months and both my arms were bright red. We still had to eat, get back to our guest house, pack our things and flag down a bus heading to Sost. It was late by the time we got out to the highway and we weren't certain we would be able to move on. Sost is the Pakistani border post and if we were to get into China the next day, we had to be there that night. We were told that there were no more minibuses running, and we ended up being picked up by a private vehicle, a large jeep with just enough room left in it for two people and their huge bags. The driver dropped us off at a hotel in Sost, of course free of charge, and extended an invitation to a sheep roast dinner. It turns out the jeep full of men were on a search for a sheep, they had been driving around from village to village looking for someone who had a sheep that wasn't up in the mountain pastures. The hotel manager finally promised to get them one, but when we went to bed it still hadn't arrived.
Before bed we had watched Golden Jubilee celebrations, torches being lit all around the village. Volunteers spend days trekking into the surrounding mountains, in a coordinated effort, hundreds of torches lit up the valley. There were even a few burning tires hurled down the mountainside, a hilarious eco-friendly activity.
The next morning, after a full check of our baggage by Pakistani officials, we boarded a government minibus and began our journey towards China and the Khunjerab Pass. With only seven passengers in the bus, the ride was pretty uneventful until we got to the Chinese security check. Each of us had our bags checked, REALLY checked. Even the hardboiled eggs and boiled potatoes from one guy's lunchbox were cracked open and smelled. The whole process was so slow it was just silly. One guard inspected everyone's bags, he seemed more curious than anything else. Meanwhile the other guards boarded our minibus, put in their music tapes and goofed off. When a Chinese truck driver arrived at the post with gifts of hard liquor they rejoiced, waving the bottles in the air. The truck passed through the gate without a security check, in the meantime our hard boiled eggs were still being sniffed. When we crossed the border into China, the gravel road became a 'super highway'. It was actually quite pitiful how modern the Chinese road was compared to the Pakistani one. The trip from the Khunjerab Pass to Kashgar crosses through Tajik and Kyrgyz communities with close up views of both the Karakoram and Pamir mountain ranges. We were now in China, but this was definetely a different China from the one we had seen before.
Country: China, Pakistan, Xinjiang Posted on Tuesday, August 07, 2007 7 comments:
Polo and Partying, Pakistani Style
We joined up in Karimabad with a Dutch girl named Margo who had also decided to leave the comfort of the Hunza Valley for the polo festival at the Shandur Pass. The pass is right on the border between two of Pakistan's territories, the North West Frontier Province (NWFP) to the west and the Northern Areas to the east. Every year thousands of people assemble there for four days of polo and partying.
We had one afternoon and evening in Gilgit to make our plans for the trip. The local bus had no seats left, so we had to find another form of transportation. Our first offer was from the guest house tour operator, who had conveniently NOT reserved us seats on the government bus, claiming that a jeep was the same cost. Funny, the jeep costs 1500 rupees per person if we can manage to fill it, and the bus costs 220 rupees per person!?!
While buying drinks at a small shop we were approached by Sana, a young, aspiring tour guide, looking to fill empty spaces in his jeep. By some miracle, Margo and Yann managed to get him to agree to sell us the spaces for 400 rupees each. After he agreed to the price he seemed to really regret it, and until he showed up to pick us up the next morning, we weren't certain if we actually had a ride to Shandur. As we suspected, the jeep "with much much room" turned into a five person jeep with eight people in it and enough food and supplies for ten. Sana had been hired by another tourist to drive up to the pass with food and supplies for a whopping 120$US while he rode there on his motorbike. By sticking us in the jeep he was just making a litle bit extra (I felt kind of cheap, but not cheap enough to pay him anything more, he had already ripped off one tourist and that was enough). Margo and I rode in the front with the driver, because Sana "respects women". Yann was stuck in the back with the four others. Up until the last 50km the ride went smoothly, we spent 4-5 hours on the paved highway gaining altitude while following the Gilgit River.
Things then got more complicated, the road turned into loose rock and Sana decided it was meal time. By this time it was late in the afternoon, all the cooking gear was strapped and packed away in the jeep. Even though we were almost at Shandur, the plan was to cook chicken biryani from scratch. Our five jeep mates didn't understand our objections (we had no tent and no organised accomodation at the pass), but agreed to only make tea and bread (a process that still involved completely dismantling the carefully packed jeep). We breaked for at least an hour, were visited by most of the local boys interested in the strange arrivals, then we finished the trip with two more hours of travel to the top of the pass. The pass is a spectacular sight, surrounded by mountains, covered in green grass, a "natural polo ground". We arrived the eve of the festival, but many tents had already sprung up all over the pass. It was getting dark, Sana had invited us for chicken biryani, but before dinner we had to find somewhere to sleep. While Yann and Margo sought out tents, I stayed back to help poor Sana. He had no idea how to set up his tent, he had forgotten a flash light, a sharp knife for food preparation and worst of all his masala biryani. Margo and Yann returned, we set up the tent and consoled frazzled Sana, telling him that his biryani would surely be good without the spices. Margo and Yann had selected a small tent inside a larger covered tent village. It was set up with a small shop, a generator providing some light and even a Chitrali musical group. After waiting over three hours for the chicken biryani, which was delicious, we walked back to our tent across the pass in the pitch black and quiet. Only one tent seemed to be generating any noise (or light), as we approached it we were overjoyed to find that it was ours. Crowds of men had gathered to listen to music and dance the night away. Helped by alcoholic 'Hunza water' and loads of hash, men volunteered themselves onto the dance floor and spun around, usually until they had crashed into the crowd. We watched in absolute awe as they partied to the beat of the Chitrali music. The lovely man next to me tried to teach me the subtle differences between Gilgiti, Pashto and Chitrali dancing. Meanwhile, Sana, a proud Gilgiti, complained the whole time that the Chitrali show wasn't as good as the Gilgiti non-existent one. The show finally collapsed when one of the heavily intoxicated musicians refused to play, feeling like the crowd wasn't throwing enough donations his way, Sana felt vindicated "this would never happen at the Gilgit show!". We were kind of grateful for the hissy-fit because we were exhausted, it was late, and there didn't seem to be an end in sight.
Margo, Yann and I squeezed into our two person tent, happy that we had rented sleeping bags, it was very cold. We awoke to the first official day of the festival, with two polo matches scheduled. After a breakfast of hot bread dunked in local honey we headed down to the polo field and joined the crowd of supporters. Watching the game start was exciting, with the players racing their horses down the field. The players ride beautifully and ruthlessly, the game here in Northern Pakistan is played with no referee. We cheered for every goal and everytime a player made contact with the ball. Half way through the game a horse made a sharp turn and his leg snapped, his rider was flung off and the poor horse shook with pain and fear. The game was stopped and the horse carried away in a small truck, we found out later that he would be euthanised. It was a wake up call to how dangerous the game actually was. In the afternoon game a horse crashed into the side barriers and threw his rider about 10 feet through the air into the crowd, this time the rider was carried away on a stretcher. During most of the game a band plays music from the stands, and at halftime they head down to the field with dancers. Spectators throw themselves onto the field to join in on the dancing, even the soldiers showed off their moves. In between the two games people pack into tents for drinking, eating, music and dancing. The atmosphere is joyful and friendly and foreigners are given a tremendous welcome. At the halfway mark of the second game, winds started to pick up and clouds of dust rose up through the valley. When the rain began we raced back to our tent only to find its staff holding onto it desperately in an attempt to keep it from blowing away. As more of the tents inhabitants appeared, we all began to grab onto random tent poles and hold on with all our strength as the wind whipped through the tent. After about an hour, the wind died down and the tent was safe. The weather never really got better though, it rained for the rest of the day, soaking the walls of our tent and keeping the cultural shows from being held. We had a cold night, with little to no sleep. We were leaving just as the festival was getting exciting and more and more people were arriving, but we had experienced a full day of polo and we didn't really have the time to stay longer. We waited all morning for the bus coming from Chitral to show up, and finally accepted a ride in a small car from two men. The driver didn't speak any English and his friend spoke almost none, but they had driven over 40 hours up to the pass with no warm clothes, had frozen through the night and then decided they were going home, without even having seen a polo match. Our driver was calm and cautious which was not the case with his friend, who smoked hash and sang at the top of his lungs for most of the 10 hour ride. He also jokingly made Yann swear not to cut off his beard, because it made Allah happy, and we wouldn't want to make Allah unhappy would we? We had two flat tires and multiple tea breaks but we made it to Gilgit before dark, which was quite a feat. We seemed to have made our two carmates extremely happy, we had somehow justified their long journey to Shandur, they hadn't seen any polo, but they had spent an entire day with three foreigners, including two women if that's not worth 80 hours of driving on shitty roads, I don't know what it.
Country: Pakistan Posted on Friday, August 03, 2007 5 comments:
Armenia Bangladesh Bolivia Cambodia Canada China Finland Georgia Hong Kong India Iran Italy Kashmir Kyrgyzstan Ladakh Laos Macau Malaysia Mongolia Myanmar Nepal Netherlands Other Pakistan Peru Qatar Singapore Spain Tajikistan Thailand Tibet Turkey USA Uzbekistan Vietnam Xinjiang
Best (and Worst) of Pakistan and the Karakoram Hig...


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Reves Center
World Minded
Fabricio Prado Introduces W&M to his Native Brazil
Overlooking Rio Courtesy Fabricio Prado
CIEE All group with all CIEE staff Courtesy Fabricio Prado
World Cup Group going to watch the Brazil vs. Switzerland World Cup match at Marina da Gloria Courtesy Fabricio Prado
Photo - of -
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by Paulina Farley-Kuzmina '20
Tucked away in the corner of Blair Hall's third floor, the office of history professor Fabricio Prado has walls lined with books about the history, politics, and governments of South America. Born and educated in Brazil, Prado has a passion for the culture and history of Rio de Janeiro that is palpable from the moment you meet him. Over the past two and a half years Prado has channeled his enthusiasm for Brazil to help create the first William & Mary faculty-led summer program in South America offered on a yearly basis. A handful of students in addition to Prado traveled to Rio de Janeiro for four weeks in June and July. The program required two three-credit courses, one on the history and culture of Rio de Janeiro taught by Prado, and the other being the first Portuguese language course to be offered through William & Mary in over a decade.
DESIGNING THE EXPERIENCE
The goal in mind when developing this program was to offer a study abroad experience in South America that offered an overview of the local culture and language as well as explored the history that connects Rio de Janeiro to the rest of the Americas, Asia, Africa, and Europe. Both the courses taught and the numerous excursions over the course of the program offered a unique interdisciplinary look at Rio de Janeiro.
"I chose Rio de Janeiro because it brings together several fields and perspectives. There is so much overlap that would attract students from different fields and with different interests, as well as in terms of faculty that can lead it," Prado said. "I wanted to create something that is sustainable, something that is not just attached to me as a professor."
Besides the historical aspect of the program, the culture of South America is relevant to Hispanic studies and Latin American studies, according to Sylvia Mitterndorfer, Director of Global Education at the Reves Center. "The Rio program addresses an unmet need, is made possible by William & Mary faculty expertise and research, aligns with university curricular priorities, and signals the importance of students having opportunities to study in South America," Mitterndorfer said.
As one of the largest ports that received and traded slaves during the 18th century, Rio de Janeiro is also a fascinating destination for students in Africana studies. Environmental sciences or biology students could be interested in the ecosystems of the Amazon, and the rapid industrialization and subsequent pollution there.
"Rio is a good place to build relationships for the university and at the same time is an ideal location from which to branch out to other areas and grasp some of the cultural and ecological diversity of the country," Associate Professor of Anthropology William Fisher said. Fisher was one of the many faculty involved in organizing the trip. "The program has already begun this process and each ensuing year will enable faculty course leaders to build on the experiences of previous years."
After the students finished their Portuguese classes in the morning, they would break for lunch and proceed to visit various museums, schools, or historical sites for Prada's history and culture course.
He provided an interactive experience by lecturing on site at whatever location they were at that day.
"My point was to make the history come alive," Prado said. "Why teach in a classroom when the historical site is so close?"
The afternoon trips included visits to the National Archives, Sugarloaf Mountain, the Botanical Gardens, and various museums. The group also took a day trip to Petrópolis, which is the summer home for the Brazilian royal family, and a weekend trip to Paraty, a colonial port preserved much like Williamsburg, and known as the place where much of Brazil's diamonds and gold were smuggled out.
Students ventured out into the city more during their down time as they become more comfortable interacting in Portuguese, with concerts and dancing being popular activities. A notable part of the study abroad experience was watching Brazil's first match of the 2018 FIFA World Cup.
"We watched the game with 5,000 other fellow Brazilians. That was a moment where we all felt the contagious joy and emotions of soccer in Brazil. It was a very deep experience for the students because we don't have that here," Prado said.
Although groundbreaking on multiple levels, this program did not evolve easily. Since the initial conception of the pro- gram in 2016 Prado has worked with the Reves Center, other faculty members, and local partners in Brazil to build a study abroad experience that encapsulates the complexity of Rio de Janeiro.
One year before the program was ready, Prado and Molly DeStafney, Associate Director of Global Education Pro- grams at the Reves Center, conducted site visits to the hostel where the students would be staying, the classroom spaces where students would take their language classes, and the surrounding neighborhoods to make sure that everything was safe and accessible. For the program, William & Mary partnered with the Council on International Educational Exchange (CIEE). CIEE not only facilitated site visits, but also managed the Portuguese classes. Prado and DeStafney met with the local representatives during that initial visit.
"I wanted to deconstruct stereotypes about Brazil. Usually when people think about Latin America or other 'exotic' parts of the world they think of danger, revolution, or beaches. They don't think about a giant metropolis with thriving business sectors or super industrialized cities," Prado said.
Prado explained that there were various reasons why South America was not a region to which William & Mary offered summertime faculty-led trips until this past year. The top priorities with the university were safety concerns and economic instability in parts of the continent. However, by working with the Reves Center and local partners in the city, Prado was able to build a program that improved security and stability for the students.
"Although faculty were committed to choosing a site in Brazil, Rio was not an easy choice. There are other places that more closely reflect faculty research interests and experience, and Brazil is such a diverse and large country that Brazilians often refer to it in the plural," Fisher said. "In the end, Rio suits because it has a lot of experience in receiving outsiders, and it has world class educational and artistic institutions."
In a more abstract sense, as the Latin American studies department developed and faculty with more diverse interests were hired, the interest in study abroad opportunities has increased.
"For years now the Latin American Studies Program has focused on expanding our offerings on Brazil," notes John Riofrio, Director of Latin American Studies and Associate Professor of Hispanic Studies. "We have felt, for a long time that you can't adequately understand the intricacies of Latin America without considering the role that Brazil has played and continues to play on the world stage. It is our hope that, along with recent experiments in offering Brazilian Portuguese here at William & Mary, we will continue to make strides in fully integrating Brazilian Studies into our already robust Latin American Studies Program.
DEVELOPING THE PROGRAM'S FUTURE
William & Mary's summer in Rio de Janeiro was an eye-opening experience not only for the students, but Prado admits for himself as well. He explains that having to guide and teach the students through the city gave him a whole new perspective on Rio de Janeiro.
"For the first time I understood Rio in all of its complexity," Prado said. "I was thinking about the city as a classroom and as a site of memory and history."
In the future, Prado anticipates that the program will grow in number for both student participants and faculty members leading the trip. He also hopes that the program will attract a varied group of students.
"I hope to see this study abroad program keeps growing and help consolidate the global outlook we have now at William & Mary."


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About Edinburgh College of Art
ECA Main Building and Hunter Building 74 Lauriston Place EH3 9DF, Edinburgh Old Town EH3 9DF
Edinburgh College of Art Website
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Welcome to Edinburgh College of Art
ECA is a vibrant and creative community of students and academics: a place of experimentation, exploration, intellectual stimulation and exciting collaborations.
We enjoy an international reputation for the quality of our teaching and research across the disciplines of art, design, architecture and landscape architecture, history of art and music. Tracing our history back to the 1770s, we remain at the forefront of teaching and research, ideally placed to engage with the challenges of the future.
Our home within the University of Edinburgh makes us distinctive, offering many opportunities to benefit from the diverse range of expertise and resources associated with one of the world's leading academic institutions.
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The FDA has approved Ironwood Pharmaceuticals' gout drug, Duzallo, although the regulator has required a black box warning highlighting risk of kidney failure.
A once-daily drug, Duzallo combines the standard of care treatment, allopurinol, with Ironwood's lesinurad.
Ironwood said the drug offers a dual mechanism of action treating inefficient excretion and overproduction of uric acid in gout patients.
Gout is a painful form of inflammatory arthritis caused by elevated levels of uric acid in the blood.
The black box on the label, the FDA's most serious side-effect warning, regards the risk of acute renal failure.
Ironwood bought rights to lesinurad from AstraZeneca last year, as the Anglo-Swedish firm is selling off certain pipeline drugs in order to raise cash to boost R&D in core areas such as cancer.
Massachusetts-based Ironwood expects its portfolio of gout drugs to generate around $300 million in peak annual US sales.
Approval of Duzallo was based on the clinical programme supporting Ironwood's Zurampic (lesinurad) monotherapy and a pharmacokinetic study that evaluated the bioequivalence of the fixed-dose combination of lesinurad and allopurinol compared to co-administration of separate lesinurad and allopurinol tablets.
The efficacy and safety of lesinurad plus allopurinol were demonstrated in two pivotal phase 3 clinical trials, CLEAR 1 and CLEAR 2, which supported the Zurampic filing.
In clinical trials of adult patients with gout who failed to achieve target serum uric acid (sUA) levels on allopurinol alone, lesinurad in combination with allopurinol nearly doubled the number of patients who achieved sUA target below 6 mg/dL at month 6, reduced the mean sUA level to less than 6 mg/dL by month one and maintained that level through month 12.


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from functools import partial

from django.apps import AppConfig
from django.conf import settings as django_settings

from elasticapm.conf import constants
from elasticapm.contrib.django.client import get_client
from elasticapm.utils.disttracing import TraceParent
from elasticapm.utils.logging import get_logger
from elasticapm.utils.wsgi import get_current_url

logger = get_logger("elasticapm.traces")

ERROR_DISPATCH_UID = "elasticapm-exceptions"
REQUEST_START_DISPATCH_UID = "elasticapm-request-start"
REQUEST_FINISH_DISPATCH_UID = "elasticapm-request-stop"

MIDDLEWARE_NAME = "elasticapm.contrib.django.middleware.TracingMiddleware"

TRACEPARENT_HEADER_NAME_WSGI = "HTTP_" + constants.TRACEPARENT_HEADER_NAME.upper().replace("-", "_")
TRACEPARENT_LEGACY_HEADER_NAME_WSGI = "HTTP_" + constants.TRACEPARENT_LEGACY_HEADER_NAME.upper().replace("-", "_")
TRACESTATE_HEADER_NAME_WSGI = "HTTP_" + constants.TRACESTATE_HEADER_NAME.upper().replace("-", "_")

class ElasticAPMConfig(AppConfig):
    name = "elasticapm.contrib.django"
    label = "elasticapm"
    verbose_name = "ElasticAPM"

    def __init__(self, *args, **kwargs):
        super(ElasticAPMConfig, self).__init__(*args, **kwargs)
        self.client = None

    def ready(self):
        self.client = get_client()
        if self.client.config.autoinsert_django_middleware:
            self.insert_middleware(django_settings)
        register_handlers(self.client)
        if self.client.config.instrument and self.client.config.enabled:
            instrument(self.client)
        else:
            self.client.logger.debug("Skipping instrumentation. INSTRUMENT is set to False.")

    @staticmethod
    def insert_middleware(settings):
        if hasattr(settings, "MIDDLEWARE"):
            middleware_list = settings.MIDDLEWARE
            middleware_attr = "MIDDLEWARE"
        elif hasattr(settings, "MIDDLEWARE_CLASSES"):  # can be removed when we drop support for Django 1.x
            middleware_list = settings.MIDDLEWARE_CLASSES
            middleware_attr = "MIDDLEWARE_CLASSES"
        else:
            logger.debug("Could not find middleware setting, not autoinserting tracing middleware")
            return
        is_tuple = isinstance(middleware_list, tuple)
        if is_tuple:
            middleware_list = list(middleware_list)
        elif not isinstance(middleware_list, list):
            logger.debug("%s setting is not of type list or tuple, not autoinserting tracing middleware")
            return
        if middleware_list is not None and MIDDLEWARE_NAME not in middleware_list:
            logger.debug("Inserting tracing middleware into settings.%s", middleware_attr)
            middleware_list.insert(0, MIDDLEWARE_NAME)
        if is_tuple:
            middleware_list = tuple(middleware_list)
        if middleware_list:
            setattr(settings, middleware_attr, middleware_list)

def register_handlers(client):
    from django.core.signals import got_request_exception, request_finished, request_started

    from elasticapm.contrib.django.handlers import exception_handler

    # Connect to Django's internal signal handlers
    got_request_exception.disconnect(dispatch_uid=ERROR_DISPATCH_UID)
    got_request_exception.connect(partial(exception_handler, client), dispatch_uid=ERROR_DISPATCH_UID, weak=False)

    request_started.disconnect(dispatch_uid=REQUEST_START_DISPATCH_UID)
    request_started.connect(
        partial(_request_started_handler, client), dispatch_uid=REQUEST_START_DISPATCH_UID, weak=False
    )

    request_finished.disconnect(dispatch_uid=REQUEST_FINISH_DISPATCH_UID)
    request_finished.connect(
        lambda sender, **kwargs: client.end_transaction() if _should_start_transaction(client) else None,
        dispatch_uid=REQUEST_FINISH_DISPATCH_UID,
        weak=False,
    )

    # If we can import celery, register ourselves as exception handler
    try:
        import celery  # noqa F401

        from elasticapm.contrib.celery import register_exception_tracking

        try:
            register_exception_tracking(client)
        except Exception as e:
            client.logger.exception("Failed installing django-celery hook: %s" % e)
    except ImportError:
        client.logger.debug("Not instrumenting Celery, couldn't import")

def _request_started_handler(client, sender, *args, **kwargs):
    if not _should_start_transaction(client):
        return
    # try to find trace id
    trace_parent = None
    if "environ" in kwargs:
        url = get_current_url(kwargs["environ"], strip_querystring=True, path_only=True)
        if client.should_ignore_url(url):
            logger.debug("Ignoring request due to %s matching transaction_ignore_urls")
            return
        trace_parent = TraceParent.from_headers(
            kwargs["environ"],
            TRACEPARENT_HEADER_NAME_WSGI,
            TRACEPARENT_LEGACY_HEADER_NAME_WSGI,
            TRACESTATE_HEADER_NAME_WSGI,
        )
    elif "scope" in kwargs:
        scope = kwargs["scope"]
        fake_environ = {"SCRIPT_NAME": scope.get("root_path", ""), "PATH_INFO": scope["path"], "QUERY_STRING": ""}
        url = get_current_url(fake_environ, strip_querystring=True, path_only=True)
        if client.should_ignore_url(url):
            logger.debug("Ignoring request due to %s matching transaction_ignore_urls")
            return
        if "headers" in scope:
            trace_parent = TraceParent.from_headers(scope["headers"])
    client.begin_transaction("request", trace_parent=trace_parent)

def instrument(client):
    """
    Auto-instruments code to get nice spans
    """
    from elasticapm.instrumentation.control import instrument

    instrument()
    try:
        import celery  # noqa F401

        from elasticapm.contrib.celery import register_instrumentation

        register_instrumentation(client)
    except ImportError:
        client.logger.debug("Not instrumenting Celery, couldn't import")

def _should_start_transaction(client):
    middleware_attr = "MIDDLEWARE" if getattr(django_settings, "MIDDLEWARE", None) is not None else "MIDDLEWARE_CLASSES"
    middleware = getattr(django_settings, middleware_attr)
    return (
        (not django_settings.DEBUG or client.config.debug)
        and middleware
        and "elasticapm.contrib.django.middleware.TracingMiddleware" in middleware
    )

redpajama_set_name: RedPajamaGithub


text:
Attorney, Army Major Declares Candidacy For 15th District
Lance Tormey Published: April 16, 2018
Jeremie Dufault is a local real estate developer, an attorney and a major in the U.S. Army and he wants to be the next rep. in the 15th district. 39-year-old Dufault has announced his candidacy for the 15th District State seat position 2 held by David Taylor.
"I want to be your voice in the legislature," says Dufault, because I believe our district deserves conservative and effective representation in olympia. We need a state representative who not only reflects our values but who supports open and honest government and who will work with others to achieve great things."
Dufault - a former Democrat - is an active and committed conservative Republican. He is the Vice Chairman of the Yakima County Republican Central Committee and was a delegate to the 2016 Republican State Convention.
Dufault lives in Selah with his wife, Amy, and two young daughters, Ellie and Lucy. He grew up in Yakima and graduated from A. C. Davis High School. He attends St. Paul's Catholic Church in Yakima.
The 15th District covers much of Selah, Yakima, Terrace Heights, Moxee, Union Gap, Wapato, Toppenish, Zillah, Granger, Sunnyside, Grandview, and Mabton.
Filed Under: 15th district, david taylor, jeremie Dufault, state representitive
Categories: News, Northwest News, The Morning News With Dave and Lance, Yakima News


text:
(function () {
    'use strict';

    ToBuyController.$inject = ['ShoppingListCheckOffService'];
    function ToBuyController(ShoppingListCheckOffService) {
        var toBuy = this;
        toBuy.buy = ShoppingListCheckOffService.getBuy();
        console.log('toBuy.buy : ', toBuy.buy);

        toBuy.buyItem = function (itemID) {
            ShoppingListCheckOffService.buyItem(itemID);
        };
    }

    AlreadyBoughtController.$inject = ['ShoppingListCheckOffService'];
    function AlreadyBoughtController(ShoppingListCheckOffService) {
        var alreadyBought = this;
        alreadyBought.bought = ShoppingListCheckOffService.getBought();
        console.log('alreadyBought.bought : ', alreadyBought.bought);
    }

    function ShoppingListCheckOffService() {
        var vm = this;
        vm.buy = [
            {
                name: "cookies",
                quantity: 10
            }, {
                name: "ron miel",
                quantity: 2
            }, {
                name: "boîte d'olives",
                quantity: 1
            }, {
                name: "pimenton",
                quantity: 2
            }, {
                name: "vin",
                quantity: 4
            }
        ];
        vm.bought = [];

        var service = {
            buyItem: buyItem,
            getBuy: getBuy,
            getBought: getBought

        };
        return service;

        function removeItem(itemIndex) {
            return vm.buy.splice(itemIndex, 1);
        }

        function buyItem(itemIndex) {
            var itemBought = removeItem(itemIndex)[0];
            vm.bought.push(
                {
                    name: itemBought.name,
                    quantity: itemBought.quantity
                }
            );
            console.log('vm.buy :', vm.buy);
            console.log('vm.bought :', vm.bought);
        }

        function getBuy() {
            return vm.buy;
        }

        function getBought() {
            return vm.bought;
        }
    }

    angular
        .module('ShoppingList', [])
        .controller('ToBuyController', ToBuyController)
        .controller('AlreadyBoughtController', AlreadyBoughtController)
        .service('ShoppingListCheckOffService', ShoppingListCheckOffService);

})();


text:
Johns Hopkins University Baltimore-India Clinical Trials Unit
BJGMC
JHU
Active Trials
Trials in Follow Up
Closed Trials
CRS Leadership MTG Minutes
CTU Directory
Network Protocol Progress Tracking List
P1108: A Phase I/II, Open-Label, Single Arm Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Bedaquiline (BDQ) in Combination with Optimized Individualized Multidrug-Resistant Tuberculosis (MDR-TB) Therapy in HIV-Infected and HIV-Uninfected Infants, Children and Adolescents with MDR-TB Disease
Study Location:
Clinicaltrials.gov Link:
https://clinicaltrials.gov/ct2/show/NCT02906007?term=P1108&rank=1
IRB#:
IRB00123844
Enrollment:
Trial Period:
This purpose of this study is to evaluate the pharmacokinetics (PK), safety, and tolerability of bedaquiline (BDQ) in combination with an optimized background multidrug-resistant tuberculosis (MDR-TB) treatment regimen in HIV-infected and HIV-uninfected infants, children, and adolescents.
The study will enroll HIV-infected and HIV-uninfected children 0 to 18 years of age treated for clinically diagnosed or confirmed intrathoracic (pulmonary) MDR-TB and certain types of extrathoracic MDR-TB. Participants will be assigned to cohorts based on age. Cohort 1 will include children 6 years of age or older but less than 18 years of age; Cohort 2 will include children 2 years of age or older but less than 6 years of age; and Cohort 3 will include children 0 months of age and older but less than 2 years of age. Cohort 1 will be divided into two weight bands, one for participants weighing 15 kg or more but less than 30 kg and one for participants weighing 30 kg or more.
Study visits will occur at enrollment (Day 0) and at Weeks 1, 2, 4, 6, 8, 12, 16, 20, 24, 32, 40, 48, 60, 72, 96, and 120. Participants in Cohort 1 will take BDQ once a day during the first 2 weeks. For the next 22 weeks, BDQ will be taken three times a week. Dosing for Cohorts 2 and 3 will be determined based on data from Cohort 1.
Study visits may include physical examinations, blood and urine collection, an electrocardiogram (ECG), medical history reviews, and other assessments.
Ages Eligible for Study: up to 18 Years (Child, Adult)
Parent/legal guardian willing and able to provide written informed consent for study participation; in addition, when applicable per local Institutional Review Board (IRB)/Ethics Committee (EC) policies and procedures, participant is willing and able to provide written assent for study participation.
Age at enrollment:
Cohort 1: 6 years of age or older but younger than 18 years of age
Cohort 2: 2 years of age or older but younger than 6 years of age
Cohort 3: 0 months of age or older but younger than 2 years of age
Weight at enrollment:
Cohort 1: At least 15 kg
Cohort 2: At least 7 kg
Documented HIV status as defined in the protocol for HIV-infected participants and HIV-uninfected participants.
Either confirmed or probable multi-drug resistant tuberculosis (MDR-TB): Confirmed intra-thoracic (pulmonary) MDR-TB, with or without one of the following forms of extrathoracic tuberculosis (TB):
Peripheral TB lymphadenitis
Pleural effusion or fibrotic pleural lesions
Stage 1 TB meningitis
Miliary and abdominal TB,
Other non-disseminated forms of TB disease
More information on this criterion can be found in the protocol.
Initiated on an optimized background MDR-TB regimen as per routine treatment decision, at least two weeks but not more than 12 weeks prior to enrollment, and tolerating the regimen well at enrollment.
If HIV-infected: Initiated an acceptable antiretroviral therapy (ART) regimen defined as either zidovudine (ZDV) + lamivudine (3TC) + abacavir (ABC) or nevirapine (NVP) + 2 nucleoside reverse transcriptase inhibitors (NRTIs) at least two weeks prior to enrollment.
If male and engaging in sexual activity that could lead to pregnancy of the female partner: Agrees to use a barrier method of contraception (i.e., male condom) throughout the first 28 weeks on study (i.e., until four weeks after discontinuation of bedaquiline [BDQ]).
If female and of reproductive potential, defined as having reached menarche and not having undergone a documented sterilization procedure (hysterectomy, bilateral oophorectomy, or salpingotomy): Negative pregnancy test at screening within 48 hours prior to enrollment.
If female, of reproductive potential (defined in the protocol), and engaging in sexual activity that could lead to pregnancy: Agrees to avoid pregnancy and to use at least two of the following contraception methods throughout the entire period of study participation: condoms, diaphragm or cervical cap, intrauterine contraceptive device (IUCD), hormonal-based contraception. It is required that the method would have had to be initiated at the time of study entry.
Among Cohort 3 participants, no documentation that estimated gestational age at birth was less than 37 weeks. Note: Infants born to HIV-infected women will be eligible for enrollment in Cohort 3 regardless of feeding mode and receipt of antiretroviral drugs (ARVs) for prevention of perinatal transmissions.
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A5253: Sensitivity and Specificity of Mycobacterium...
An estimated 3 million HIV-infected individuals will enter programs for antiretroviral (ARV) treatment in the coming year, with...
P2026: Pharmacokinetic Properties of Antiretroviral and...
IMPAACT P1026s, the predecessor of this study, was first approved in 2003. P1026s enrolled over 1000 pregnant/postpartum women,...
P1078: A Phase IV Randomized Double-Blind Placebo-Controlled...
P1078 is a Phase IV, randomized, double-blind, placebo-controlled study of HIV-infected pregnant women and the infants born to...
P2001 (DAIDS ID 12026): Evaluating the Pharmacokinetics,...
TB is a major cause of illness and death in women of reproductive age. Pregnant and postpartum women with latent TB are at...
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PK, safety and acceptability data and practical guidance on the optimal dosing of new more child-friendly formulations of...
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text:
Fraser Forster 2023: Net Worth, Salary, and Earnings
8 January 2023, 20:03 PM
Fraser Forster is an English professional footballer. He plays as a goalkeeper for the Premier League club Tottenham and England national football team. Read the full article to know Forster's net worth, age, salary, height, and other information.
About Fraser Forster:
Fraser Forster's Net Worth and Salary:
Forster's Wife:
His Height and Weight:
Forster's Endorsements:
Fraser Forster's stats:
Premier League: Southampton
Fraser Forster ● Welcome to Tottenham Hotspur ⚪ Super Saves!
FAQ about Fraser Forster:
What is Fraser Forster's Net Worth in 2023?
What is Forster's Annual Salary?
Is He Married?
Fraser Forster began his career at Newcastle United in 2005. He was the club's third goalkeeper in the 2007-08 season. Fraser didn't play the club's first team throughout the six years he was there. This was primarily because he spent the majority of his time on loan to other teams frequently, for full seasons.
During his time at Newcastle, he went on loan thrice. Firstly, he went to Stockport Country during the 2008-09 season. Secondly, he signed a monthly loan with Bristol Rovers on 31 July 2009. Lastly, he went to play for Norwich City for a season.
At first, Forster joined Celtic as a loan on 24 August 2010. There he made his debut only after 4 days. That season he kept 24 clean sheets in 44 matches for Celtic. As a result, the club extended his contract for another season. During the 2021-22 loan season, he played 47 matches for the club and kept 26 clean sheets. Following this, the club signed him permanently with a £2 million deal with Newcastle united. Forster stayed at the club till 2015.
Forster's transfer was agreed upon between Celtic and Southampton on August 8, 2014, with a rumored fee of about £10 million. On August 17, 2014, he made his Premier League debut. He regularly played for the club up until 2018. By July 2018, he was demoted to the backup position. He transferred to his former team Celtic as a loan player the following season. Forster recently took part in a substantial portion of Southampton's 2021–22 Premier League games. He appeared 19 times in total. Forster started all 38 games in which he has appeared.
Forster left Southampton on June 8, 2022. He was signed by Tottenham on a free transfer on July 1 after his contract there expired.
Fraser Forster's net worth is €7 Million (£6 Million) in 2023. He recently joined Tottenham Hotspur on a free deal from Southampton. Additionally, it was reported that the player took a pay cut to join the north London-side club. Previously he earned £3,744,000 annually from Southampton. When he first joined the club permanently in 2014, his yearly salary was £2.1 million. Before that, the player played for Celtic. There he earned a weekly wage of £25,000. At present, his market value is just above €2 million. It peaked at €15 million back in 2016.
Full Name Fraser Gerald Forster
Nickname Fraser Forster
Height 6 ft 7 in (2.01m)
Weight 205lbs (93kg)
Birthplace Hexham, England
Nationality English
Net Worth €7 Million (£6 Million)
Father's Name Brian Clive Forster
Salary £3 million
Twitter Handle @FraserFosterGK
Instagram Handle @fraserforster
Fraser Forster is currently single. He hasn't married yet. Previously, he was in a relationship with Leah Totton. Totton is a famous Northern Irish physician. They met back in 2009 and began an affair. Their affair stood around for 4 years. Following this, they broke up in 2013.
Forster was born on March 17, 1988, in Hexham, England. At present, he is 34 years old.
The English footballer has a height of 6 ft 7 in (2.01m) and weighs 205lbs (93kg). He is amongst the tallest goalkeepers in Premier League. Often the player is seen exercising in the gym to keep himself in shape.
Thanks to a late yet successful career, Forster managed to sign a few good sponsorship deals. He signed a brand deal with the American sportswear brand Under Armor in 2017. He has also been a long-term sponsor of Nike. As so, he used the Nike Mercurial Superfly 8 Elite during the 2021-22 season. Additionally, the player has a glove deal with The One Glove. As part of their deal, Forster uses the GEO 3.0 Carbon during games.
Fraser Forster's net worth is €7 Million (£6 Million) in 2023.
The English footballer's annual salary is £3 million.
No. Fraser Forster is currently single.
Related: Clement Lenglet Net Worth


text:
Home Equine Wellness Rollkur Dressage Ruling and Response
Reader Says Horse has Turned Mean
Our Readers Write
Rollkur Dressage Ruling and Response
Hyperflexion decision
by Dr. Robert Cook
Following constructive debate at the FEI round-table conference at the IOC Headquarters in Lausanne February 9, the consensus of the group was that any head and neck position achieved through aggressive force is not acceptable. The group redefined hyperflexion/Rollkur as flexion of the horse's neck achieved through aggressive force, which is therefore unacceptable. The technique known as Low, Deep and Round (LDR), which achieves flexion without undue force, is acceptable.
The group unanimously agreed that any form of aggressive riding must be sanctioned. The FEI will establish a working group, headed by Dressage Committee Chair Frank Kemperman, to expand the current guidelines for stewards to facilitate the implementation of this policy. The group agreed that no changes are required to the current FEI Rules.
The FEI Management is currently studying a range of additional measures, including the use of closed circuit television for warm-up arenas at selected shows.
The group also emphasized that the main responsibility for the welfare of the horse rests with the rider.
The FEI President HRH Princess Haya accepted a petition of 41,000 signatories against Rollkur presented by Dr Gerd Heuschman.
SCROLL DOWN for reaction from Dr. Robert Cook, creator of Bitless Bridle
The participants in the FEI round-table conference were:
HRH Princess Haya, FEI President
Alex McLin, FEI Secretary General
Margit Otto-Crépin, International Dressage Riders Club Representative
Linda Keenan, International Dressage Trainers Club Representative
Sjef Janssen, Dressage Representative
Frank Kemperman, Chairman, FEI Dressage Committee (by conference call)
François Mathy, International Jumping Riders Club Representative
David Broome, Jumping Representative
Jonathan Chapman, Eventing Representative
Roly Owers, World Horse Welfare Representative
Tony Tyler, World Horse Welfare Representative
Ulf Helgstrand, President, Danish Equestrian Federation
John McEwen, Chairman, FEI Veterinary Committee
Dr Sue Dyson, Veterinary Representative
Dr Gerd Heuschman, Veterinary Representative
Prof. René van Weeren, Veterinary Representative
Jacques van Daele, FEI Honorary Steward General Dressage
Graeme Cooke, FEI Veterinary Director
Trond Asmyr, FEI Director Dressage and Para-Equestrian Dressage
John Roche, FEI Director Jumping and Stewarding
Catrin Norinder, FEI Director Eventing
Carsten Couchouron, FEI Executive Director Commercial
Richard Johnson, FEI Communications Director
The Federation Equestre Internationale (FEI), founded in 1921, is the international body governing equestrian sport recognized by the International Olympic Committee (IOC) and includes 133 National Federations. Equestrian sport has been on the Olympic program since 1912 with three disciplines - Jumping, Dressage and Eventing. It is one of the very few sports in which men and women compete on equal terms. It is also the only sport which involves two athletes - horse and rider. The FEI has relentlessly concerned itself with the welfare of the horse, which is paramount and must never be subordinated to competitive or commercial influences.
'Low, Deep and Round' or a blow, deep and unkind?
Dr Robert Cook FRCVS, PhD ([email protected])
Once again, the FEI has rejected the evidence and another opportunity for reform has been lost. Over bending may be acceptable to the FEI but it is not acceptable to the horse. The FEI is just dodging the issue by changing the name of the shame. 'Low, Deep and Round' is simply a synonym for 'Rollkur,' hyperflexion and over bending. 'Rollkur' by any other name smells just as rotten. A semantic sleight of hand will not stop this regrettable practice.
Yet there is a way to establish a humane requirement for the degree of poll flexion to be permitted. Such a guideline already exists in the FEI rule book and it is one easily monitored by stewards in the warm-up ring. The rule book requires a horse to be 'on the bit.' Part of the FEI's own definition of this phrase reads: "...the head should remain in a steady position, as a rule slightly in front of the vertical..." So I agree that, in this respect at least, there is no need to change the rule book. All that the FEI has to do is to abide by it. 'Low, deep and round' transgresses the rule book. It also transgresses the injunction that a horse be "calm, supple, loose, and flexible..." and "must not be subjected to any training methods which are abusive or cause fear."
The FEI's assertion that the practice of 'low deep and round' achieves flexion without undue force is refutable. Apart from the FEI's unfortunate endorsement of the concept that force of any sort is an acceptable part of training, how would they define 'undue' or 'aggressive'? Such words merely provide loopholes through which any lawyer could drive a double-decker bus. Furthermore, it is noted that in commending 'low, deep and round' (LDR) they are quietly substituting the word 'flexion' for 'hyperflexion.' Yet LDR involves hyperflexion and this is not a physiological position for a horse's head to be in during forward motion. Even at the walk, no horse at liberty would choose to place its head in such a position.
The statement, "...the main responsibility for the welfare of the horse rests with the rider" is an abrogation of the FEI's responsibility. Are they washing their hands of any requirement on their part to promote equine welfare? If so, they renounce the primary justification for their very existence.
The question should have been determined on the basis of the scientific evidence, not by consensus. By all means let's have a debate, preferably an open debate. And after the debate, let the decision be based on the evidence of equine anatomy and physiology. Scientific truths are not determined by majority vote.
If we do not protest the FEI's current non-compliance with nine of the ten items in their own code of conduct, we must all bow our heads in shame that human beings have once again failed to show humanity.[i]
Robert Cook, FRCVS, PhD
Professor of Surgery Emeritus, Cummings School of Veterinary Medicine
[i] No. 5 is the only one in which the FEI may be in compliance. "Adequate provision must be made for ventilation, watering and maintaining a healthy environment during transportation."
Cook, W.R. (2007): "Why is Rollkur Wrong?" Available online at www.bitlessbridle.com
dressage training natural horsemanship fei bitless bridle
equine nutrition
holistic horse
equine massage therapy


Popping Culture: Worst. Bribe. Ever.
Steven T. Denton, 32, was charged with a felony count of attempting to bribe a law officer after he allegedly offered to spring for McDonald's cheeseburgers in exchange for his release.
The officer added, "He also stated that if I did not like cheeseburgers, he would buy me some chicken instead."
Well, McDonald's does serve all white meat now. Does that change your attitude?
Heh. I once sat in on a guy who had been grabbed by security at work. He asked the security guy, "Hey, do you like boating? I have a boat--we could just go out this weekend."
It was great. Security guy was like, "Um, no, I don't think we'll be doing that."