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World High Life PLC Announces Brand Ambassador Agreement with Georges St-Pierre (GSP) for the Company and its Love Hemp Brand
PRESS RELEASE ACCESSWIRE
May. 5, 2020, 09:05 PM
LONDON, UK / ACCESSWIRE / May 6, 2020 / World High Life Plc (OTCQB:WRHLF) is pleased to announce that it has finalised an agreement with 3-time UFC Champion of the World, Georges St-Pierre, as brand ambassador for World High Life and the Company's Love Hemp brand.
"World High Life and Love Hemp aspire to be world leading pioneers for CBD health and wellness and we are therefore thrilled to have Georges St-Pierre join our team and provide his legendary leadership and vision toward the expansion of Love Hemp's already significant business throughout the UK and more extensively into Europe and beyond," said Mr. David Stadnyk, Chairman and President of World High Life.
As Brand Ambassador, Mr. St-Pierre will facilitate and provide promotional services, including branding, social media, product placement, endorsement and overall support of the Company and the "Love Hemp" brand.
Georges St-Pierre Highlights
Born in St-Isidore, Québec, on 19 May 1981
26 wins (8 by knockout, 6 by submission, 12 by decision) 2 defeats
Two-time Welterweight Champion of the World, including nine consecutive successful title defenses from 2008 to 2013 - Ultimate Fighting Championship (UFC)
Middleweight Champion of the World, 2017 - Ultimate Fighting Championship (UFC)
Fighter of the Year 2009 - Sports Illustrated, World MMA Awards, MMAPayout, Inside MMA, MMAJunkie
Canadian Athlete of the Year 2008, 2009, 2010 - Rogers Sportsnet
Finalist - Best Fighter 2008, 2010, 2011, 2018 - ESPY Awards
Most Dangerous Man of the Year 2010 - Spike Guys Choice Awards
2008 MMA Fighter of the Year - Black Belt Magazine
Georges "Rush" St-Pierre, also known as "GSP," is a Canadian professional mixed martial artist and UFC world champion who holds black belts in both Kyokushin karate and Brazilian Jiu Jitsu.
In 2006 he became the UFC Welterweight Champion. He lost the title in 2007 but subsequently regained it in front of his hometown fans of Montreal in 2008 and hasn't lost a single title defence since then.
Georges retired from the sport on 13 December 2013, holding the UFC record for most wins in title bouts and then returned to the octagon after a four-year layoff, on 4 November 2017 at UFC 217 in New York City (Madison Square Garden), where he defeated Michael Bisping by submission in the third round to win the UFC Middleweight Championship title, becoming the fourth fighter in the history of the organization to be a multi-division champion. On 7 December 2017, after being diagnosed with ulcerative colitis, Georges vacated his UFC middleweight title and officially announced his retirement from professional MMA competition on 21 February 2019.
Recognized as one of the planet's best pound-for-pound MMA fighters and all-around athlete, GSP lives in Montreal and still travels around the world to train with the best coaches and training partners in all disciplines.
"Using Love Hemp's CBD products in my training helped my recovery and overall well being greatly, I embrace this opportunity to help create innovative products and grow the Love Hemp brand so that others can benefit as well," said Mr. Georges St-Pierre. "I am committed to building great teams and getting world class results in everything I do, and the World High Life and Love Hemp team have shown me they have everything it takes to achieve that world class standard."
Brand Ambassador Agreement
The agreement with Georges St-Pierre has been entered into with his management company Georges St-Pierre Enterprises Inc ("GSPE") and expires on 31 December 2021, during which term Georges St-Pierre has agreed to make a number of appearances for the Company and Love Hemp Limited as well as to promote the Company and Love Hemp's products through social media. GSPE has agreed that the initial fees due under the agreement can be settled by an issue of 69,630 new ordinary shares of 10p each in the Company ("Ordinary Shares").
Following this issue of Ordinary Shares, for the purposes of the Financial Conduct Authority's Disclosure Guidance and Transparency Rules, the Company has 14,159,440 Ordinary Shares in issue, each share carrying the right to one vote. The figure of 14,159,440 should be used by shareholders in the Company as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change to their interest in, the Company under the Financial Conduct Authority's Disclosure Guidance and Transparency Rules.
The Directors of the Company accept responsibility for the contents of this announcement.
About Love Hemp
Love Hemp is one of the UK's leading CBD and Hemp product suppliers and has more than 40 product lines, comprising oils, sprays and vapes and a variety of edible and water-based CBD products. Love Hemp has established relationships with over 1,200 stores in the UK, including leading brands such as Ocado, Holland & Barrett and WH Smith.
About World High Life
World High Life was established by the founders of Supreme Cannabis (TSX:FIRE), and 1933 Industries (CSE:TGIF), both companies at the forefront of the legalized cannabis industry. LIFE was established to take advantage of the huge opportunities available in the UK and European legal cannabis space, which is set to be the largest in the world within five years.
David Stadnyk
World High Life PLC
North America toll-free, 1 (888) 616-WRHLF (9745)
info@worldhighlife.uk
NEX Exchange Corporate Adviser
Mark Anwyl/Allie Feuerlein
Peterhouse Capital Limited
ma@peterhousecap.com
af@peterhousecap.com
Camilla Horsfall/Megan Ray
Blytheweigh
Camilla.horsfall@blytheweigh.com
Megan.Ray@blytheweigh.com
For more information on World High Life please visit: https://www.worldhighlife.uk
Cautionary Note Regarding Forward Looking Information
We seek safe harbour. Some statements contained in this news release are "forward looking information" within the meaning of securities laws. Forward looking information include, but are not limited to, statements regarding the use of proceeds of the non-brokered private placement and payment of the debt settlements. Generally, forward-looking information can be identified by the use of forward-looking terminology such as "plans", "expects", "is expected", "budget", "scheduled", "estimates", "forecasts", "intends", "anticipates", "believes" or variations of such words and phrases (including negative or grammatical variations) or statements that certain actions, events or results "may", "could", "would", "might" or "will be taken", "occur" or "be achieved" or the negative connotation thereof. Investors are cautioned that forward-looking information is inherently uncertain and involves risks, assumptions and uncertainties that could cause actual results to differ materially. There can be no assurance that future developments affecting the Company will be those anticipated by management. The forward-looking information contained in this press release constitutes management's current estimates, as of the date of this press release, with respect to the matters covered thereby. We expect that these estimates will change as new information is received. We do not undertake to update any estimate at any particular time or in response to any particular event, except as required by law.
SOURCE: World High Life PLC
https://www.accesswire.com/588619/World-High-Life-PLC-Announces-Brand-Ambassador-Agreement-with-Georges-St-Pierre-GSP-for-the-Company-and-its-Love-Hemp-Brand
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Spouse: Darren Le Gallo (m 2015 - present)
Children: Aviana Olea Le Gallo
Parents: Kathryn Adams, Richard Adams
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Economic Outlook – 18 August 2019
The spread between the US two-year Treasury note and the 10-year note fell below zero for a time this week, setting of a recession warning bells. However, the inversion is not yet persistent, and in the past five such episodes the onset of recession averaged 22 months after inversion. Global bond yields continue to tumble, with US 10-year notes falling to their lowest level in three years and German, British and Japanese yields falling to record lows. The US 30-year bond yield fell below 2.0% for the first time on record.
The consensus is that Fed will continue its risk management approach and it is on course to cut rates another 25 basis points in September. The negative yield curve raises the probability that they take further action in the months ahead. The Fed is right to be wary of the risks from trade tensions, as evidence that tariffs are hitting the US economy continued to mount last week.
Initial Job Claims last week's uptick to 220k is still not flagging much of anything, and the 4-week average is barely above cycle lows. Production/nonsupervisory work hours have drifted down in recent months. The six-month growth rate is now the weakest since 2009, but the year-over-year change is within this cycle's range (albeit at the low end). Other indicators like the jobless rate are more lagging in nature. All in, the labour market is not flashing much at the moment.
Core capital goods orders have actually improved since the turn of the year through June, though year-over-year growth has faded to a skinny 1.5%. In the factory ISM, new orders have slowed significantly through July and are clinging to the 50 (neutral) level. Nonmanufacturing orders, while firmer at 54.1 in July, have also faded. This one bears watching, especially with trade tensions only heating up in August and business confidence likely suffering further
The lack of strength in housing is interesting especially given the plunge in mortgage rates (down about 120 bps since late-2018 for a 30-year). Sales have picked up somewhat, but remain more or less rangebound. Building permits encouragingly rose firmly in July after grinding lower for much of the past year. All told, we're still seeing stagnation/saturation on the housing front, but not a rollover that would be indicative of recession.
The Commerce Department reported that retail sales, excluding autos, jumped 1.0% in July, the best showing in four months, helping build on optimism over healthy sales at Walmart. On Friday, however, the University Michigan reported that its preliminary reading on consumer sentiment fell more than expected and hit its lowest level since January. Weekly jobless claims also rose more than expected and hit their highest level since late June. Meanwhile, poor data out of China and Germany confirmed a substantial slowdown in global manufacturing, with rising trade barriers seemingly to blame. Investors also worried about political turmoil in Hong Kong and elections in Argentina
US stocks recorded a third week of losses as trade and growth worries unsettled investors. The bulk of the week's declines came Wednesday, with the major benchmarks suffering one of their worst daily pullbacks to date in 2019. The smaller-cap benchmarks underperformed, and the S&P Midcap 400 Index briefly joined the small-cap Russell 2000 Index in correction territory, or down over 10.0% from the highs it reached in late August 2018. The Cboe Volatility Index (VIX) remained elevated but stayed somewhat below the eight-month peak it reached the previous week. With many investors on summer holidays, trading volumes were somewhat thin, which may have accentuated the market's moves.
As investors rushed to the perceived safe haven of the Treasury market, the yield on the benchmark 10-year note fell as low as 1.48%, just above the record low it reached in the summer of 2016. Meanwhile, the yield on the 30-year bond fell below 2.0% for the first time.
On Thursday, the preliminary Markit PMIs for August and the leading index are due out. The Markit manufacturing PMI is expected to fall below the 50 threshold in line with the weakness seen in the manufacturing in the rest of the world but the service PMI is likely to hold up. Overall, it would signal US GDP growth is slowing.
On Wednesday, the FOMC minutes from the July meeting are due out. A lot has happened since the meeting so the minutes may seem hawkish in the current context. There are not scheduled any Fed speeches (it seems as if they may be on summer holiday) but the Jackson Hole conference (Thursday to Saturday) is interesting. The theme is 'Challenges for Monetary Policy' which suggests it will focus on the same things as in the FOMC review of the current monetary policy framework. The agenda has not been published yet.
British retail sales unexpectedly edged up in July, helped by the strongest growth in online spending in three years, as consumers continued to support the economy before the 31 October Brexit deadline. Monthly retail sales volumes rose 0.2% after a 0.9% surge in June, the Office for National Statistics said on Thursday, beating the average forecast for a 0.2% decline from a Reuters poll of economists. Compared with July 2018, sales were up 3.3%, slowing from 3.8% in June but at the top end of forecasts.
Britain's labor market showed unexpected strength in the second quarter but economists said this could prove a high water mark, after figures last week showed the economy contracted as businesses braced for a potentially disruptive Brexit. Average weekly earnings rose by an annual 3.7% in the three months to June (the highest rate since June 2008 and up from 3.5% in May. Excluding volatile bonuses, annual pay growth reached 3.9%) also an 11-year high and beating economists' average forecast in a Reuters poll.
Prime Minister Boris Johnson's government has made billions of pounds of new spending commitments in its first three weeks in office, even before the potential costs of a disruptive, no-deal Brexit are taken into account. New Finance Minister Sajid Javid will give more details of the plans next month, before a full annual budget later in the year – assuming that a no-confidence vote and an election do not intervene before then.
In the UK there are no market movers this week.
Anticipation of an aggressive package of additional easing measures from the European Central Bank at its September meeting is helping fuel the global bond rally after a member of the bank's governing council made a forceful case for additional accommodation in an interview with the Wall Street Journal. Lest anyone question the veracity of the Journal's reporting, Finnish central banker Olli Rehn tweeted out a link to the article. Rehn said the ECB is preparing a strong package of measures and that it is important to overshoot expectations rather than undershoot. The starkest example of Rehn's determination to signal a strong move was his assertion that the ECB has not ruled out purchasing equities as part of its quantitative easing program, a once-unthinkable prospect.
Eurostat reported that the eurozone economy barely grew in the second quarter of 2019, expanding just 0.2%, as economies across the bloc lost steam. The region's largest economy, Germany, shrank by 0.1% in the second quarter, according to Destatis, the statistics agency. The gross domestic product flash estimates numbers, including year-on-year growth of 1.1% from the second quarter of 2019, were in line with economists' forecasts. The report showed that Spain's economy grew 0.5%, France's expanded 0.2%, and Italy's economic growth was flat for the same period. Other signs of slowing were seen in the 1.6% June downturn in eurozone industrial production.
Trade between countries of the eurozone fell in June at the fastest pace in more than six years as the China-US trade dispute begins to hit European exports. The value of intra-eurozone trade dropped 6.6% in June compared with the same month last year. Eurozone exports to the rest of the world fell 4.7%, and European exports to China contracted 3.4% for the same period.
Stock markets in Europe came under pressure throughout the week from fresh US – China trade tensions and growing signs of recession. The pan-European STOXX Europe 600 Index lost about 0.5% and the exporter-heavy German DAX index dropped about 1.3%.
In the euro area the most important data items this week are the PMI prints from Germany and the euro area on Thursday. In July, the already fragile euro area manufacturing sector continued to plunge to 46.5 (a 6.5 year low) while the service sector held broadly steady at 53.2. Weak external demand and geopolitical risks still haunt the manufacturing sector while domestic demand underpins the service sector, albeit companies have become more cautious about investment and also started to reassess staff levels.
The ECB minutes will be out on Thursday and deserve attention. The discussion of the new policy measures will be scrutinised, but not much flavour in terms of operational details will be revealed as 'tasked committees' are working on this.
The US – China trade skirmish continues to make news as market-supportive headlines keep getting pushed off the page by less upbeat ones. Markets were relieved midweek as the United States announced it was delaying the imposition of tariffs on several categories of imports from China until after the holiday season, but that news did not dissuade China from announcing that it intends to take necessary countermeasures to match the US tariffs. Face-to-face negotiations are expected to resume within two weeks, and China has asked the US to meet it halfway on trade issues. However, US President Donald Trump said that that a trade deal needs to be reached on "our terms," though he said he believes the trade war will be fairly short, noting that US and Chinese negotiators had a very good conversation last week.
Air traffic out of Hong Kong was severely disrupted this week as protestors occupied the city's international airport and clashed with police. The prolonged nature of the protests has resulted in Hong Kong's government suggesting it will downgrade its forecast for gross domestic product to 0% to 1.0% this year from its earlier 2.0% to 3.0% forecast. The government also unveiled an economic support package worth $2.4 billion to offset some of the economic drag from the demonstrations. President Trump this week for the first time linked the protests in Hong Kong to the ongoing trade negotiations with China, saying the country must respond humanely to the protests if it wants to strike a trade deal. Trump's remarks came amid signs that the Chinese government is gearing up to employ the Chinese People's Armed Police to quell the protests, massing a force in Shenzhen, just across the border from Hong Kong.
Chinese stocks posted a weekly gain after Beijing pledged to roll out measures to boost disposable incomes for the next two years to offset the slowing economy. For the week, the benchmark Shanghai Composite Index added 1.77%, and the large-cap CSI 300 Index, which tracks blue chips listed on the Shanghai and Shenzhen exchanges, rose 2.11%. Most of the weekly advance occurred on Friday, after Beijing announced that it would roll out a plan to boost disposable income this year and in 2020 to spur private consumption, Reuters reported. The statement from the National Development and Reform Commission, China's state planning agency, included few details, yet raised hopes that China's government would step up efforts to stimulate domestic demand. A spate of solid earnings reports from some of China's biggest companies also lifted sentiment.
All the main indicators of Chinese economic growth weakened more than expected by consensus in July. Industrial production growth fell to just 4.8 % year-on-year, the lowest on record except for a few New Year-distorted months back in the early 2000s. Retail sales growth fell from 9.8 % year-on-year in June to 7.6 %, a decline that can be only partly explained by the fading of the boost from rebates on older cars ahead of implementation of new emissions rules. Finally, fixed investment growth disappointed by falling from 6.3 % to 5.2 % in ordinary year-on-year terms. The overall picture is that the surprising growth uptick in June has been eliminated and that the direction continues to be downward. Looking at the sub-components of fixed investment reveals that the authorities' preferred way of stimulating growth (infrastructure and property investments) both slowed in July. Only the industry's fixed investment growth increased, but that is unlikely to last amid the ongoing trade war. This holds despite Trump's decision to delay (not abolish) the imposition of import tariffs on some Chinese goods.
In China there are no market movers this week.
Sources: T. Rowe Price, Reuters, MFS Investment Management, Handelsbanken Capital Market, TD Economics, Danske Bank, BMO Economics.


Sandals Grande St. Lucian's over-the-water accommodations are proving to be hugely popular with couples on honeymoon or a romantic vacation.
We interviewed top Caribbean travel specialists about the region's hottest honeymoon and wedding travel trends. Here are the hottest tips that Travel Agent dished out for those of you seeking to be successful in selling this lucrative niche market.
The South Pacific may have perfected the over-the-water room category for decades, but its success in this market was never mainstream.
New over-the-water bungalows in both the Caribbean and Mexico, however, have opened this market up to scores of East Coast travelers, who always thought this type of accommodation was either too expensive or too far away.
"Caribbean resorts are wooing travelers with the 'wow' factor, creating incredible resorts and vacation experiences, including over-the-water bungalows and wedding chapels, and bars with overwater hammocks at Sandals Resorts; elaborate waterparks, family suites, special amenities for babies and kids at Nickelodeon Hotels & Resorts Punta Cana; and headliner concert events and music festivals to attend plus opportunities for travelers to create their own rock star experiences at Hard Rock Hotel & Casino Punta Cana," says Jack E. Richards, president and CEO of tour operator Pleasant Holidays.
The over-the-water room category was first introduced to the Caribbean back in 2016 by Sandals Resorts International. But it looks like Sandals could have some company soon in that market, as all-inclusive competitor AMResorts announced plans in 2017 to open a Zoëtry Resort in Aruba that features the category.
In December of 2016, Sandals announced that the much-anticipated Over-the-Water Suites at Sandals Royal Caribbean in Montego Bay, Jamaica, were officially open and ready to be booked.
Sandals then declared in February the launch of nine new Over the Water Honeymoon Butler Bungalows at Sandals Grande St. Lucian. Finally, on December 16, Sandals announced that Sandals South Coast's 12 new Over the Water Bungalows were open to guests.
As part of our coverage of Classic Vacations' STAR Performer event at Dreams Playa Mujeres Golf & Spa Resort in Mexico last year, we got the skinny on AMResort's plans for a new Zoëtry Resort in Aruba that will include the company's first-ever over-the-water bungalows.
Mount Cinnamon Resort & Beach Club, a seaside enclave, is one of the mid-range properties promoting Grenada as a honeymoon destination.
In fact, all of the roughly 130 rooms at the Aruba resort will be over-the-water bungalows, says Susan Lang, AMResorts' regional sales manager for the Northeast.
Karisma Hotels & Resorts' Palafitos — Overwater Bungalows in Mexico "are, of course, generating tremendous buzz, so we anticipate [Zoëtry Resort's] over-the-water bungalows in Aruba will be a source of even more excitement when those open," Scott Wiseman, president of Travel Impressions, tells Travel Agent.
Just as Sandals has created buzz around the over-the-water room category in the Caribbean, it is also responsible for creating excitement over the island of Tobago, which has always served as a two-day getaway from sister island Trinidad, but now may be able to stand on its own as a viable option for a four- or five-day honeymoon.
And that's because Sandals' most loyal advisors and clients were most likely paying attention when the company issued a statement back in October announcing official plans to open both a Sandals Resort and a Beaches Resort on Tobago. It will be interesting to see if Sandals' presence on the island will influence increased airlift to the destination, as it has done in other destinations like Grenada.
Also, as part of our recent Caribbean trends feature, Caribbean experts, including Wiseman and Dave Ferran, head of sales for Classic Vacations, hinted smaller islands such as Grenada and Nevis are picking up steam heading into the new year.
Ferran says there is also interest in St. Kitts, with the recently opened Park Hyatt St. Kitts, while Wiseman points to St. Lucia as an island that continues to perform well, propped up by high-end resorts such as Cap Maison, Jade Mountain, Rendezvous, The BodyHoliday and Sugar Beach, A Viceroy Resort — all excellent options for honeymoons with a side of health and wellness.
Grenada's profile has grown considerably, with Spice Island Beach Resort catering to the affluent market, and mid-range properties such as Mount Cinnamon Resort & Beach Club and Coyaba Beach Resort attracting value-seekers.
"For the Caribbean and Mexico, we are seeing a large amount of clients interested in doing split stays in St. Lucia, Antigua and Barbados…usually avoiding some of the larger all-inclusive chains and wanting more local and boutique options," says Mitch Toren of Trip Guy Travel.
The recently opened Park Hyatt St. Kitts, according to Dave Ferran, head of sales for Classic Vacations, has helped in developing travelers' interest in the island of St. Kitts.
When it comes to planning an excellent bachelor or bachelorette party, the destination most advisors pointed to in the Caribbean was the Dominican Republic. Terrah Van Meter, an advisor with Legacy Travel, notes the Dominican Republic, specifically Punta Cana, is home to the hottest hotel brand in the Caribbean for these types of celebrations.
Wiseman says the Dominican Republic also attracts this type of celebration travel mainly because of the products offered and the accessibility.
"The Caribbean is well-suited to weddings and bachelor / bachelorette parties in general, but Dominican Republic stands out as a leader in this market due to its accessibility from a variety of U.S. gateways, affordability of airfare, and diverse range of product," Wiseman adds.


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Home About Everest News Everest Insurance® Adds Two Members to Retail Excess Casualty Team
Everest Insurance® Adds Two Members to Retail Excess Casualty Team
Everest Insurance® is pleased to announce the addition of Erin Bouren and Mike Ludy to the Retail Excess Casualty team.
NEW YORK, NY – June 10, 2019 – Everest Insurance® is pleased to announce the addition of two members to the Retail Excess Casualty team:
Erin Bouren will be leading the team's Western Territory as Vice President. She comes to Everest with more than 17 years' experience. Prior to her role at Everest, Erin held the title of Vice President of Underwriting at Conifer Holdings, Inc. She has also worked in underwriting roles at Ironshore, Arch Insurance Group, and Berkshire Hathaway. Erin holds a Bachelor of Arts degree from the University of Michigan. Erin will be based in the Everest Insurance® San Francisco office.
Mike Ludy joins Everest Insurance® as a Director on the Excess Casualty team. Mike most recently held the role of Assistant Vice President, Excess Casualty, at Aspen Insurance. Earlier in his career, he worked as a senior underwriter at both Chubb and Canopious Group, and as a broker at Arlington/Roe & Co. Mike holds a Bachelor of Science in Finance and Insurance from Illinois State University. Mike will be based in the Everest Insurance® Chicago office.
"We are excited to have Erin and Mike join the Excess Casualty team," said Debbie Weiser, Head of Excess Casualty. "Their combined experience in their respective regions, and significant industry knowledge, will be valuable assets to the team."
Commenting on the additions, Connie Germano, Head of Specialty Casualty, added, "Erin and Mike are two key hires in the Central and West territories as we work to expand the retail capabilities and resources of our Excess Casualty team. Their proven underwriting expertise and deep client relationships will support our expansive nationwide retail casualty footprint."
Everest Re Group, Ltd. ("Everest") is a leading global provider of reinsurance and insurance, operating for more than 40 years through subsidiaries in the U.S., Europe, Bermuda and other territories.
Everest Insurance® markets property, casualty, specialty and other lines of admitted and non-admitted direct insurance on behalf of Everest Re Group, Ltd, and its affiliated companies.
Additional information about Everest, our people, and our products can be found on our website at www.everestre.com. All issuing companies may not do business in all jurisdictions.


4 UK Players in the First Four Rounds?
Draftwire has four Wildcats in it's latest mock draft which covers the first fours round of the upcoming NFL Draft. Josh Allen is a consensus top 3 pick and there are plenty of sources that believe the same thing that BBN believes, he's a number 1 pick. Logic would tell you that the defensive player of the year should go before other defensive players, but, no one ever said that NFL owners used logic. Benny Snell and Derrick Baity are projected to go in the third round according to draft wire and if I know Benny like I think I do, he'll make all the teams that passed him up regret it. I can't wait to watch him play in the pros. Lonnie Johnson is projected to go in the fourth round but a lot of sources are seeing how his length could translate well to the NFL, wouldn't be surprised to see him sneak into the second round. That leaves a few guys out like Bunchy Stallings, CJ Conrad (3rd-5th round projection from walterfootball.com), Darius West, and Mike Edwards (both 3rd-5th round projections from walterfootball.com). The NFL Scouting Combine is set for Feb. 26th – March 4th and the official invitee list is still under works. I expect to hear any day now that Kentucky has multiple players invited. Keep tuned and Go Big Blue!
Previous Marlin Devonshire Come on Down!!!


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Successfulness of the technical professionals and managers requires - in addition to the deep technical knowledge – special understanding on the strategic management of the external challenges, the leadership of the people and organizations, the enterprises, the development and sales of the products and services, the technical and market regulation of the whole ecosystem, the international technological, business and regulatory trends. The Engineering Management discipline builds a bridge between the technical and managerial sciences.
The Engineering Management Laboratory (EMLab) is an educational and research unit of the Department of Telecommunications and Media Informatics. EMLab systematically follows Engineering Management discipline at large and focuses on the digital ecosystem and the management of the information and communication technologies (ICT) in conformity with the profile of the Faculty of Electrical Engineering and Informatics.
Applications of decision theory, game theory, simulation and group-work methods.


"Not a bad place, but beware advance bookings"
The guesthouse itself was relatively nice. The room was quite comfortable and clean, the breakfast was good and there was no curfew which I like. The show was very weak though.
The problem with this guesthouse was my advance booking. I booked 10 months in advance of my stay, paying my deposit at the time. The guesthouse took the money after 3 months without any notice. It was fortunate that I had the money in my account at that time, but it did almost cause an unarranged overdraft. When I spoke to the management they didn't see a problem with what they had done and were in fact very rude. They also wouldn't arrange for refunding the payment (to then be paid again on arrival) without cancelling my reservation and offering no guarantee I could stay the night!
"Great guesthouse for a good price!"
We got to the guesthouse a few hours before check-in as we were attending a wedding. But there was no problem leaving our bags there and they let us know how the go about to get into our room later on, they were very helpful. Nice clean rooms, breakfast really nice, can't complain on anyting really!
I´ve stayed with a friend for four days in the Ingledene House, Bournemouth and it was really nice. Nice, cosy rooms, good breakfast, close to the beach, friendly service - I can warmly recommend this B&B.
Only one little point of criticism: The morning we wanted to leave, no-one was around to collect the keys for the rooms - so we had to leave them in the room... unfortunately we didn´t get back our pledged money either.
We were going to a gig in Bouremouth so decided that we would stay over the night as it was also my girlfriends birthday the day after.
We booked this through Hostelworld dot come and with Hostelworld regs you pay a 10% deposit when you book, then the remainder when you arrive at the hotel or check out.
I received a call from the owner the night I booked the hotel online asking for my card details, I then received an email stating that he had taken the remainder of the payment that evening.
The hotel did smell a bit greasy and you get this as soon as you walk in. For one night stay just to crash somewhere, fine, but not really any longer.


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Book Title Reviews For Author Reviews By Author
Leah Brooke
Jlg29
laurasbookbinge
snubhermit28
chewzyb
Bebanie
Reviews for A Roll of the Dice (MF)
Avg - 4.82
A Roll of the Dice (MF) by Tymber Dalton (Published by: Siren-BookStrand, Inc. )
Categories: BDSM, Contemporary
This reviewer's rating: 5 - Outstanding
Nice to have on older couple getting into BDSM. The story treats the subject matter just right.
Reviewed by: Booklvr (Date: 04/18/2018)
Total reviews by this reviewer: 34 See all my reviews
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See all MER reviews for this title: A Roll of the Dice (MF)
See all MER reviews for this author: Tymber Dalton
Amazing!! I am absolutely in love with this series. I love the fact that many of the characters from Tymber's other books in this series make appearances throughout. This one is so easy to relate to because I think that most couples feel the way Jenny and Mike feel at some point in their lives. I love the raw emotion that she creates and the excitement the characters build throughout the story. Tymber mixes a good amount of humor, angst, love and sexiness to make it so you can't stop reading until you finish. Which sometimes is in one evening. I can't wait to read more from this amazing series and I hope she doesn't have plans to end it anytime soon!
Reviewed by: Karen Peacock (Date: 12/13/2014)
Total reviews by this reviewer: 6 See all my reviews
I love how this story portrayed the real struggle of an established couple who are entering a new phase of life. Jenny feels she'd like to try something new and Mike is fearful that it is more than he is comfortable with and what it will mean for them as a couple. We see their internal struggle as well as their discussions with each other and their friends. We also see the learning process as they figure out how to balance each other's needs and comfort levels.
Reviewed by: Katy Beth (Date: 11/09/2014)
Total reviews by this reviewer: 103 See all my reviews
Another great book. I love how the characters were older, like me. Thanks Tymber.
Reviewed by: mommabear (Date: 10/16/2014)
There hasn't been one book in the whole series that has been a disappointment. Tymber draws you in emotionally from the very beginning. Loved the story line that had more do with a mature couple.The laughs were just at the right place and well, the tears too.
Reviewed by: othbrand (Date: 10/08/2014)
Tymber Dalton has written another wonderful addition to her Suncoast Society series. This story is one that I could relate to on a personal level. Michael and Jenny are embarking on a journey after being married for 25 years that will help them to enhance their marriage if they will allow it to. I have never been disappointed by this author!
Reviewed by: Lisaflipz (Date: 10/05/2014)
i love all the books in the Suncoast Society and this is no exception. Well written, loveable and real characters who you can relate to easily. Tymber has a way of writing that makes you feel apart of the story and you can really relate to the characters. There were no tears this time round but it was still an emotional journey i mixed up my reviews :( so the review for A clean sweep should say there were plenty of tears!
Reviewed by: Ali (Date: 09/24/2014)
Loved this book. The story drew me in. It was a great book. I can't for Gilo's story.
Reviewed by: homehair (Date: 09/15/2014)
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Embrace your vulnerability – it's very easy to say, but not always easy to do. And yet this is one of the key themes from this heartfelt and inspirational TED talk from academic researcher and author Brené Brown.
Her story and her research started with an initial determination to figure out and beat vulnerability, to deconstruct shame. After years of hard work, however, she came to the realization that this simply was not possible. Not only that, it wasn't wise.
After a genuine breakdown for which she had to seek help, Brené now preaches the virtues of vulnerability and its power to bring us closer together, to allow our true selves to shine through and our real feelings to be felt.
Her talk tells us the difference between those people who have a strong sense of love and belonging and those who don't; it turns out that believing you are worthy of love and belonging is the key. Such people also had courage – the ability to "tell the story of who you are with your whole heart" and to accept their imperfections.
What's more, she tells us that we can't numb the bad feelings without numbing the good feelings too. We're more fixated on perfection and certainty than ever before because of the fear we have of the uncertain and the imperfect.
In the end, Brené wraps things up by suggesting that when we let ourselves feel vulnerable, we let ourselves feel alive, we truly and deeply connect with other people, and we can say "I am enough" with a whole-hearted conviction.
Watch and enjoy this enthralling talk and leave your comments below.


Developments in single photon emission tomography instrumentation and reconstruction methods present a potential for decreasing acquisition times. One of such recent options for myocardial perfusion imaging (MPI) is IQ-SPECT. This study was motivated by the inconsistency in the reported ejection fraction (EF) and left ventricular (LV) volume results between IQ-SPECT and more conventional low-energy high-resolution (LEHR) collimation protocols. IQ-SPECT and LEHR quantitative results were compared while the equivalent number of iterations (EI) was varied. The end-diastolic (EDV) and end-systolic volumes (ESV) and the derived EF values were investigated.
A dynamic heart phantom was used to produce repeatable ESVs, EDVs and EFs. Phantom performance was verified by comparing the set EF values to those measured from a gated multi-slice X-ray computed tomography (CT) scan (EFTrue). The phantom with an EF setting of 45, 55, 65 and 70% was imaged with both IQ-SPECT and LEHR protocols. The data were reconstructed with different EI, and two commonly used clinical myocardium delineation software were used to evaluate the LV volumes.
The CT verification showed that the phantom EF settings were repeatable and accurate with the EFTrue being within 1% point from the manufacture's nominal value. Depending on EI both MPI protocols can be made to produce correct EF estimates, but IQ-SPECT protocol produced on average 41 and 42% smaller EDV and ESV when compared to the phantom's volumes, while LEHR protocol underestimated volumes by 24 and 21%, respectively. The volume results were largely similar between the delineation methods used.
The reconstruction parameters can greatly affect the volume estimates obtained from perfusion studies. IQ-SPECT produces systematically smaller LV volumes than the conventional LEHR MPI protocol. The volume estimates are also software dependent.
Myocardial perfusion imaging (MPI) using single photon emission computed tomography (SPECT) has been shown to have good prognostic power for diagnosing coronary artery disease [1, 2]. Gated MPI has shown to significantly reduce the number of so-called borderline cases when interpreted simultaneously with stress and rest perfusion images . In addition, post-stress left ventricle ejection fraction (LVEF) and end-systolic volume (ESV) have incremental prognostic value over perfusion information in predicting cardiac death .
In recent years, developments in both SPECT MPI reconstruction methods and hardware have been in part affected by clinical desire of increased and more economical patient throughput. In addition to novel SPECT camera models dedicated to MPI , introduction of collimator-detector response compensation and other advanced noise reduction methods into the iterative reconstruction algorithms  have made faster or 'low activity' MPI imaging generally available .
IQ-SPECT is a cardiac imaging software and hardware option for Siemens general purpose gamma cameras  (Siemens Healthineers, Erlangen, Germany). The three main components of IQ-SPECT are variable-focus collimators (SmartZoom), a cardio-centric acquisition orbit and an iterative reconstruction algorithm incorporating collimator-detector response compensation for the SmartZoom collimators . It has been shown using static cardiac phantoms that IQ-SPECT preserves both image quality and the results of quantitative measurements with a quarter of the acquisition time or a quarter of administered activity used in conventional MPI [8, 10]. Caobelli et al. have also compared the LEHR protocol with a one-fourth acquisition time IQ-SPECT protocol and found no significant differences in perfusion scores . Recently, they have shown with patient data that one-eighth time IQ-SPECT protocol produces statistically comparable results with the one-fourth protocol and could provide significant improvement in patient throughput of an MPI centre . However, Havel et al. have shown how IQ-SPECT produces significantly higher summed stress, rest and difference scores, lower EF values and higher left ventricular (LV) volumes than the conventional LEHR imaging protocol with filtered back projection reconstruction . On the other hand, Horiguchi et al. have shown that the number of projections in an IQ-SPECT study has a significant effect on thallium-201 MPI results . By increasing the number of projections per camera head from the recommended 17 to 36, they produced MPI images equivalent to those using conventional SPECT. In addition to reconstruction methods and imaging protocol, it has also been shown by Caobelli et al. that the positioning process of the cardio-centric orbit at the beginning of the acquisition can have an effect on diagnostic accuracy of the IQ-SPECT imaging . As the published results remain inconsistent, it is difficult to have a clear conclusion on the reliability of IQ-SPECT.
In a recent study, Joergensen and Hansson measured 28 patients' EFs using IQ-SPECT from two different reconstruction datasets and also with multi-gated planar equilibrium radionuclide ventriculography (MUGA) . The reconstruction parameters for IQ-SPECT were 15 iterations, 2 subsets and 10-mm Gaussian post-filter (protocol A) and 12 iterations, 1 subset and 10-mm Gaussian post-filter (protocol B). They concluded that none of the IQ-SPECT protocols evaluated in the study were comparable with MUGA, and they stated that '[IQ-SPECT protocol A or B] is not suitable for evaluation of LVEF [(left ventricular ejection fraction)] in critical settings, e.g., in control of chemotherapy or evaluation of cardiac pumping efficiency'.
In this study, we validate a dynamic heart phantom using gated CT imaging. Then, we evaluate the absolute LV volume quantification accuracy of IQ-SPECT and compare the calculated LVEF to a conventional LEHR acquisition protocol (EFIQSPECT and EFLEHR, respectively). Our study is motivated by the inconsistency in the EF and LV volume results between IQ-SPECT and LEHR protocols, as discussed above. In addition, to our knowledge, the effect of reconstruction parameters on EF has not been explicitly studied in any prior IQ-SPECT investigations. We investigate how the number of reconstruction iterations affects the EF estimation in a high signal, no background phantom setup.
EFIQSPECT and EFLEHR were measured using a dynamic heart phantom (PTW-Freiburg GmbH, Freiburg, Germany) capable of varying EF and beats per minute (BPM). The phantom can also give a trigger signal to a SPECT or computed tomography (CT) system via an electrocardiography (ECG) connector.
where EDV and ESV are the largest and smallest phantom volumes corresponding to the end-diastolic and end-systolic volumes, respectively. The heart phantom volumes were validated using gated CT imaging (EDVTrue, ESVTrue and EFTrue) as a reference. These were then compared with estimates from clinical IQ-SPECT and LEHR acquisition protocols.
The phantom consists of two main parts: a pump unit and a membrane unit. The membrane unit of the phantom was placed within a NEMA IEC PET body phantom (Fig. 1). The EDV is varied by changing the amount of water pumped into the membrane unit, while ESV remains constant. The nominal EF settings used in this study were 45, 55, 65 and 70%. According to the manufacturer, the phantom pump unit produces highly accurate and repeatable volumes and thus possible error between cardiac cycles was considered negligible. However, the membrane sizes may vary slightly between units, and thus, the ESV was verified with a CT scan and manual measurements.
During the IQ-SPECT and LEHR acquisitions, the myocardial volume of the phantom was filled with a solution of 300 MBq of 99mTc-pertechnetate diluted with 400 ml of distilled water. A high amount of 99mTc activity was used to produce statistically high-quality SPECT projection data. This non-clinical concentration was used to distinguish the effect of iteration numbers from other confounding factors such as (denoising) filter choice or delineation software performance on low statistics data. The activity concentration within the myocardium space was verified with gamma counter measurements to ensure consistency between acquisitions. The CT was carried out without introducing radionuclides or contrast agents.
To validate phantom volume accuracy and consistency, the dynamic heart phantom was scanned with a second-generation dual-source Siemens SOMATOM Definition Flash CT system. ECG-triggered cardiac CT scans were performed at 60 bpm with four different EF settings: 45, 55, 65 and 70%. EF 65% was additionally scanned at heart rates of 40, 50, 60 and 70 bpm. The scanning parameters used in the measurements were tube voltage 100 kVp, slice collimation 2 × 128 × 0.6 mm with z-flying focal spot, gantry rotation time 280 ms, quality reference tube current-time product 320 mAs per rotation (CareDose 4D), and pitch factor 3.4. The time resolution of the scans was 75 ms. The mean volume CT dose index and dose length product were 36 mGy and 570 mGy cm, respectively. For comprehensive evaluation of the phantom volumes, images with a slice thickness of 0.6 mm and an increment of 0.6 mm were reconstructed with an I26f reconstruction kernel (SAFIRE level 2) from 21 cardiac phases (0–100% with 5% intervals) for each scan. The reconstructed image field of view was set to 150 mm and the matrix size to 256 × 256 resulting in near-isotropic voxels.
For ESV validation, a non-gated CT scan of the resting state phantom was performed with a chest CT scan protocol. The scanning parameters were 120 kVp, 128 × 0.6 mm slice collimation, 0.5-s rotation time, 0.6 pitch and 120 quality reference mAs. Images with a slice thickness of 0.6 mm, an increment of 0.6 mm, 150 mm FOV and 512 × 512 image matrix were reconstructed using the B30f kernel. In addition, ESV was manually measured by dipping a relaxed inner membrane unit into a water path. The water bath was placed on a high precision scale, and the replaced water mass was measured with the scale and interpreted as volume.
The following analysis was carried out individually on all the data sets and cardiac phases and on the non-gated reference volume. Each volume was resampled to align along the horizontal long axis with isotropic 0.6-mm resolution using bicubic interpolation. A double-peaked Gaussian function (see Fig. 2) was fitted to the volume histogram using a simplex search method of Lagarias et al.  implemented in MATLAB (MathWorks, Natick, MA, USA). The water-membrane segmentation decision threshold was set at the half-value of the obtained Gaussians' peak locations. As the CT number of water is expected to be near zero, the resulting threshold is approximately half of the mean CT number of the membrane wall. While preserving the membrane boundary 3-D morphological dilation, erosion and hole-filling were applied to remove the clutter caused by image noise. Each segmented slice was verified visually to only hold voxels belonging to the innermost phantom volume and the corresponding membrane wall. LV volumes from all the 4-D acquisitions and time points were determined to ensure segmentation algorithm stability. The EFTrue values for each phantom setting were calculated using the smallest (ESVTrue) and largest volumes (EDVTrue). EF 65% acquisitions with different BPM settings were used to further assess the phantom measurement and analysis consistency and repeatability.
Both acquisitions were performed using the same dual head gamma camera (Siemens Symbia T2) using ECG-gating with eight bins. The data were acquired into a 128 × 128 matrix producing a 4.8-mm voxel size. The energy window was centred at 140 keV with 15% width. The IQ-SPECT protocol was based on the manufacturer's recommendations with an extended acquisition time of 30 s per view. IQ-SPECT covers a 204° scanning arc with an angular step of 6.12°. A total of 34 projections were acquired. To ensure repeatable positioning, the phantom was first aligned with camera's lasers. Then, the first cardio-centric orbit setup was marked on the surface of the phantom with a cobalt-57 pen-point and a regular marker. The following cardio-centric orbit setups were focused with the help of the cobalt-57 pen-point marker on the surface markings of the phantom. The radius of the rotation was constant (28 cm) for the IQ-SPECT due to the cardio-centric orbit.
The LEHR protocol had a scanning arc of 180° with an angular step of 1.4° and an acquisition time of 25 s per view. A total of 128 projections were acquired with camera heads in the 90° cardiac configuration. For the LEHR acquisitions, the phantom was positioned at the centre of the field of view (FOV), but the acquisition was carried out using a non-circular orbit and auto-contouring as is routinely carried out in clinical scanning.
The gated LEHR projection data were reconstructed using ordered subset expectation maximization (OSEM)-based Flash3D iterative reconstruction (Siemens Healthineers, Erlangen, Germany). IQ-SPECT data were reconstructed using Siemens implementation of conjugate-gradient iterative algorithm. No attenuation correction was used as it was not supported in the reconstruction software for gated data. Because the algorithms included a collimator-detector response compensation and the projection data had high signal-to-noise ratio, filtering was not applied. The images were reconstructed using different combinations of numbers of iterations and subsets, but henceforth, the results will be presented as a function of equivalent number of iterations (EI), i.e. the product of the number of iterations and the number of subsets.
The EF and LV volumes were calculated using Quantitative Gated SPECT software (QGS, Cedars-Sinai Medical Center, Los Angeles, USA) and Corridor4DM (4DM, University of Michigan Medical Center, USA) with an automatic myocardium delineation. For 4DM, 'Mid membraneous Septum' algorithm was used for delineation .
The LV volumes of different cardiac phases measured from the gated CT are shown in Fig. 3. The measured ESVTrue, EDVTrue and EFTrue values are presented in Table 1. The differences between measured EFs and phantom settings were less than one percentage point. In addition, the ESV was verified with non-gated CT scan and with manual measurements, and the ESVTrue was found to be 34.0 and 32.9 ml, respectively.
Representative gated SPECT images for EF setting 65% with different EI values are shown in Fig. 4. There are distinct differences between LEHR and IQ-SPECT images, resulting in smaller ventricle volumes in the latter. For example the 'myocardium' is shorter and thicker in the IQ-SPECT than in LEHR images. Also, the apex thickening, often seen in clinical images, is visible in the IQ-SPECT data.
The EF values for the IQ-SPECT and LEHR protocols as a function of EI are shown in Fig. 5a, b. In both protocols, the EF calculations depend highly on the number of reconstruction iterations; for low number of iterations, both algorithms greatly overestimate the EF. This results from the slow convergence of the reconstruction algorithms and underestimations of the volumes (also seen in Fig. 6). Both algorithms slowly approach a stable EF value around 30 EIs, but with higher EI, proceed to underestimate EF from 5 to 10 percentage points.
The volume estimates of ESV and EDV for different number of EIs are shown in Fig. 6 for both imaging protocols with corresponding true volumes (dashed lines) determined during CT validation. EDVs and ESVs can be seen to converge towards the true physical volumes produced by the phantom. The volume estimates keep increasing over the studied EI range, but the 'stroke volume' (EDV-ESV) reaches a constant after approximately 10 iterations. This explains the decreasing phenomenon in the calculated EF with QGS software (Fig. 5a); the EDV and ESV increase, but the difference between them remains constant. In contrast, 4DM does not alter the cardiac muscle thickness as much as QGS with higher EIs. Therefore, similar increasing volume phenomenon is not as clearly present (Fig. 5b), and EF is more stable with high number of EIs. However, The IQ-SPECT produced systematically smaller volumes than LEHR protocol at the studied iterations range.
The best EF estimates and the associated number of EIs, EDVs and ESVs are shown in Table 2. Percentage difference (ΔEDV and ΔESV) between SPECT protocol and corresponding CT volumes are also shown. With the right choice of EIs both protocols produced EF values within one percentage point of the EFTrue. However, the absolute volume estimates were approximately 40 and 20% lower for IQ-SPECT and LEHR, respectively, when compared to ESVTrue and EDVTrue. IQ-SPECT required a higher number of EIs to reach the EFTrue values, possibly due to a smaller number of projections and a more complex reconstruction process. The slower convergence of the IQ-SPECT reconstruction is also shown in Fig. 7, where the cardiac cycle volumes of the phantom (phantom EF setting 65%) are compared with the corresponding CT data using different number of equivalent iterations.
EF and LV volume estimates are clinically important parameters, but accurate volume determination is a non-trivial task prone to errors with any clinically available imaging modality . Using gated MPI, the overall perfusion, EF and LV volumes can be estimated with a single imaging session simultaneously and the results are highly reproducible and in good agreement with other imaging techniques [20–23]. However, conventional MPI is time consuming for both the patient and for the imaging facility. Thus, there is a need for faster MPI acquisition techniques, both non-gated (for perfusion) and gated (LV function). IQ-SPECT presents an innovative combination of improved reconstruction methods and collimator design that increases system sensitivity at the centre of the cardio-centric orbit allowing reduced acquisition time or injected activity. Several groups around the world have compared IQ-SPECT with other nuclear medicine imaging techniques and protocols, although studies show conflicting results (see Background).
In this study, we have validated the volumes of a novel dynamic heart phantom using gated CT imaging and subsequently used the phantom to evaluate the accuracy of the EF estimates of two clinically used, IQ-SPECT and LEHR, MPI protocols. The CT results showed that phantom measurements were repeatable and accurate. Based on the measured EF accuracy (within 0.6% of the set values), consistency between different EF 65% acquisitions (within 0.2%), good correspondence to the values reported by the manufacturer and an acceptable level of uncertainty in the estimated absolute volumes, we conclude that the CT EF measurements are accurate enough to be treated as references for SPECT analyses.
Using the validated dynamic phantom, we showed that the EF and LV volume results using clinical IQ-SPECT and LEHR protocols are highly dependent on the number of reconstruction iterations (Fig. 5a, b). Both methods could accurately estimate the EF of the phantom, the error being one percentage point or less (Table 2). The absolute LV volumes were systematically underestimated more with IQ-SPECT than with LEHR (Fig. 6a, b). The LV volume calculations could be improved by using a higher number of iterations but that, in turn, would lead to increasingly underestimated EF values. These results imply that reporting the reconstruction parameters is of great importance, especially when comparing different MPI protocols. These findings can partly explain the inconsistency of the previously published results discussed in the Introduction.
The IQ-SPECT volumes were found to be systematically lower than the LEHR volumes. We presume that the underestimation of the volumes is mostly due to the limited number of views in the IQ-SPECT protocol and the LV volume estimates could be improved significantly if the number of views was increased. This hypothesis is supported by results from Horiguchi et al. , who showed that increasing the number of views from 17 to 36 in a 201Tl IQ-SPECT protocol results in more equivalent images to those acquired using conventional SPECT. We also hypothesize that increasing the number of views could rectify the deformed phantom shape in the IQ-SPECT (Fig. 4). Acquisition protocol optimisation is a very interesting topic and is currently under investigation by our group.
In this study, we did not use any background activity around the heart phantom since we aimed to omit confounding factors when studying IQ-SPECT and LEHR performance on myocardium phantom volume estimation. Our future studies, including imaging protocol optimisation, will include this omission. Attenuation correction was not used due to reconstruction software limitations for gated data. Further study is needed to determine if including attenuation correction in the reconstruction would improve the volume estimates as well as produce more faithful perfusion representation especially for gated IQ-SPECT.
Another issue that separates the phantom measurements from a clinical setting arises from analysis software used to analyse the gated SPECT images. The automatic myocardium delineation process in the QGS and 4DM software has an inherent anatomic model that may give different EF and LV volume results for a symmetrical phantom compared to a real human heart. All automated delineations were successfully processed without manual adjustment, and no clear faults in the delineations were not visible. We believe that the software effect on the results is small and, if present, is systematic and affects both LEHR and IQ-SPECT protocols equally.
In this study, all SPECT acquisitions were carried out using eight gating bins as per our standard clinical imaging protocol. The number of the bins affects the volume definition, and it has been shown that using eight bins underestimates LVEF by approximately 4% compared to 16 bins, primarily due to a poorer temporal resolution . Fortunately, the underestimation is quite uniform over a wide range of LVEFs and can be taken into account when interpreting the LVEF values. In patient data, the use of 16 bins gating is usually limited by low count statistics of the SPECT projections that appears as poor image quality.
As IQ-SPECT has a high sensitivity, it should be possible to overcome the low count statistics and improve the volume assessment accuracy. However, the optimal acquisition protocol has still to be determined. Routinely, low statistics and noise in images are compensated by using post-reconstruction filters. Filtering helps to reduce noise but at the same time blurs the images to some extent. This evidently affects the SPECT volume and defect determination. Blurring caused by filtering has a similar effect on the LV volume and EF values as reducing the number of iterations has. From Fig. 5, we can see that the images with low number of EIs are blurred and that appears as underestimations of the LV volumes (Fig. 7) and an overestimation of the EF (Fig. 6). OSEM-based reconstruction algorithms tend to create grainy images if noise is present, and the number of iterations is increased. Because in our study a high activity concentration was used, this effect was not prominent and therefore no post-filtering was applied.
We validated the volumes of a dynamic heart phantom using gated CT imaging. With the validated phantom, we showed that a clinical routine IQ-SPECT protocol produces systematically smaller LV volumes than a LEHR protocol. Both protocols could achieve accurate EF estimates, but the EF values were very dependent on the reconstruction parameters, which should be taken into account when comparing different imaging protocols. The optimal acquisition protocol for MPI with the IQ-SPECT warrants further study.
The authors thank Jim O'Doherty from The PET Centre, King's College London, for proofreading the manuscript.
The study was designed by authors EH and EK. Authors TM and TK were responsible for the gated CT imaging and analysis of the CT data. The author EH carried out most of the SPECT acquisition and data analysis and also prepared the manuscript. All the authors have read, commented and accepted the manuscript.


If a woman wants to break up, she will always find reasons or make them up!
Her reasons are usually very simple!
She takes distance because she has another man in mind, wants her freedom back, can't deal with tensions or simply outgrows the relationship.
Very often she won't tell you why she breaks up.
She will invoke something you did 3 years ago or an aspect of your personality she no longer likes.
Why won't she give you her real motives?
Because her inner motives are part of her battle plan.
If she unveils them to you, she opens up emotionally to you and that's the last thing she wants when she is trying to get her freedom back.


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Manchester Airport conman is jailed for 16 months
Gary Lyon, 50, (pictured) was jailed for 16 months
A callous conman who duped complete strangers into giving him cash handouts by falsely claiming members of his family were either ill or dying has been jailed.
Gary Lyon, 50, tugged on the heartstrings of kind-hearted holidaymakers flying into Manchester Airport by falsely telling them he needed money to visit his seriously ill father in hospital.
One businessman taken in by Lyon's sob story unwittingly handed over £20 while the following day an elderly woman of 67, flying in from Prague was conned into giving Lyon another £20.
The offences occurred just months after Lyon, of Wythenshawe, Manchester had been freed from jail over a similar scam in which he scrounged money by falsely claiming his 11-year old daughter had cancer and was lying gravely ill in Christie Hospital, of Manchester, 'with tubes coming out of her arms.'
He claimed he needed money as he had run out of petrol on the way to see her in hospital. His daughter has in fact made a full recovery.
At Manchester Crown Court, Lyon, who admitted fraud by false representation, was jailed for 16 months by a judge who condemned him for his 'wicked lies'.
The court heard the incidents occurred across two evenings in November 2017, when passengers were flying back into the UK.
Lyon claimed his father had suffered a heart attack and he needed to visit him in hospital.
Businessman Peter Cheung, 57, was told Lyon's car had broken down and he needed money to buy fuel. Lyon promised to pay him back giving him his number to transfer the money but when the victim called later on, Lyon never answered.
The next day Lesley Berry, 69, was picked up at the arrivals hall by her husband, who had recently been discharged from hospital for respiratory problems.
Lyon (left) tugged on the heartstrings of kind-hearted holidaymakers flying into Manchester Airport (right) by falsely telling them he needed money to visit his seriously ill father in hospital
But as they were carrying her suitcases to the car, Lyon approached and offered to carry the bags. Mrs Berry politely refused and carried on walking but Lyon grabbed the suitcases and took them to the boot of their vehicle.
He then told the couple he wanted a 'favour' from them as he needed money to get to his father in hospital.
Lyon again promised he would pay the money back but when the woman refused to hand any cash over, he got aggressive and marched her to a nearby cash machine.
For fear of her safety, the woman withdrew £40 and gave Lyon £20.
But he said this wasn't enough and that he would get the rest from her husband who was waiting in the car. The woman ran after Lyon and he fled from the scene.
Police tracked down Lyon from the phone number he gave to the Mr Cheung.
Lyon later claimed he went to the airport for his birthday with his son and was embarrassed that he couldn't afford to buy his son a drink – and as a result began asking people for money.
But the court heard he had 43 previous convictions and had also previously stolen from his 70-year-old disabled mother Anna to fund his '£50 per day' cocaine habit. He was jailed for 18 months in 2015.
One businessman taken in by Lyon's sob story unwittingly handed over £20 while the following day an elderly woman of 67, flying in from Prague was conned into giving Lyon another £20
In mitigation defence lawyer Thomas Mckail said: 'He is ashamed at these offences but drugs have affected his life and he welcomes the opportunity to prove himself to all of those he let down.'
Sentencing Lyon on Friday 26 January, Judge Anthony Cross QC told him: 'You were doing what you had done for a very long time – looking for victims. Our society is made richer by people like Peter Cheung and Leslie Berry yet they had the misfortune to meet you.
'You have a very bad record and will not learn your lesson. You talk about your own disabled mother and how unhappy you were not being able to spend Christmas with her – but this is the same mother you defrauded in the past. Shame on you.'
After the case Det Con Alex Wild of Greater Manchester Police said: 'Lyon preyed on the good nature of innocent people and took advantage of them, faking family illnesses, which no-one would wish on their loved ones.
'It seems he was oblivious to the effect his offending was having on people but today I'm sure it's explicitly clear to him that he is now where he is because of his own sickening actions.'


World-class Filipino artistry will once again be celebrated as Tanghalang Pilipino, the resident drama company of the Cultural Center of the Philippines, concludes its 25th Theater Season with EYEBALL: New Visions in Philippine Theater. This production features four of the best plays from the Virgin Labfest, the yearly festival of new works for the theater. The select plays deal with the theme, "Searching" and tackle man's search for love, for lost family bonds, for noble ideals, for closure, and for missing loved ones.
EYEBALL will be shown as two sets of twin-bills. Set A includes Carlo Pacolor Garcia's hilarious Bakit Wala Nang Nagtatagpo sa Philcoa Oberpas, directed by Riki Benedicto, which tells the story of a man and a woman who decide to meet at the Philcoa Overpass after months of flirting online.
The cast of this riotous play includes TP Actors Company members Jonathan Tadioan, Jelson Bay, Martha Comia, Marco Viaña and Gino Ramirez; and guest artists Pam Hundana and Carmina Capile. In Doc Resureccion: Gagamutin ang Bayan, by Layeta Bucoy (Directed by Tuxqs Rutaqio), a well-meaning doctor runs for Mayor only to find out that the community he so wanted to help desires a different path for itself. This intriguing work features action-packed performances of Riki Benedicto, Jonathan Tadioan, Rayna Reyes and Miss Sherry Lara.
EYEBALL: New Visions in Philippine Theater opened on January 13, 2012 and runs for four weekends until February 12, 2012 at the CCP Tanghalang Aurelio Tolentino (Little Theater). Regular ticket price is Php600, with student and senior citizen discounts.
For ticket reservation, booking of special performances and other information, please call the TP office at 832-3661, 0920-9535381 or 0928-5518645. You may also contact the CCP Box Office at 832-3704 and Ticketworld at 891-9999 for ticket inquiries.


text:
#ACT UP
While receiving a lifetime achievement award, the infectious disease expert shares memories and insights.
"The issue is AIDS. Where do the candidates stand on education, health care, discrimination? Your vote is a weapon. Use it. We are at war!"
The results of the 2020 election will have many long-term consequences. There isn't an issue that won't be greatly affected, including HIV.
ACT-Up Style "DIE IN" at UVA in #Charlottesville Today
Schools around the country are bringing students back to campus despite Covid-19 concerns. In Charlottesville, it's not going over well.
R.I.P. Peter Stinner, an HIV Educator and ACT UP Activist in Atlanta
Over two decades, he helped thousands of clients at Grady Health System's Ponce de Leon Center.
Remembering the Passion of Larry Kramer
In this reminiscence about his friend, the founder of POZ shares personal insights on the late author and activist.
Masked Crusaders
These masks keep HIV messaging in everyone's face while raising funds for a good cause.
Invaluable Treasure
Charles King is the CEO of Housing Works, a nonprofit fighting the twin crises of HIV and homelessness in NYC.
HIV Nonprofit Housing Works Opens COVID-19 Homeless Shelters
Both shelters are located in New York City hotels.
Uncovering Untold Stories of AIDS and the Catholic Church
The podcast series "Plague" explores historic conflicts and quiet compassion between the church and LGBTs during the early HIV epidemic.
Young Adult Novelist
What happens when a girl with HIV wants to have sex? The answer lies in Camryn Garrett's "Full Disclosure."
And Now for an AIDS Performance That Reflects the Great Unknown
Jack Waters and Peter Cramer guide us through "Generator: Pestilence Part 1," which includes a "scent score" and premieres in NYC.
CBS Fires Reporter Who Stoked Fears of an "HIV ATTACK"
The incident prompted New York activists to rally against HIV stigma and for bail reform.
How The Philadelphia Center Was Born
ACT UP brought an HIV/AIDS agency to life in Shreveport, Louisiana.
Housing Works Employees Walk Off the Job in an Effort to Unionize
The New York City nonprofit fights homelessness and HIV.
R.I.P. Andy Vélez
The longtime AIDS activist died of complications resulting from a severe fall on May 14 at the age of 80.


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