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Payment for plasma raises ethical issues
Wendy Glauser
CMAJ September 02, 2014 186 (12) E446; DOI: https://doi.org/10.1503/cmaj.109-4855
Toronto, Ont.
An Ontario-based company is now compensating donors for plasma, giving rise to a divide in the medical community about the safety and ethics of paying for blood.
Canadian Plasma Resources is waiting on licence approval from Health Canada, but is already paying plasma donors in a pilot phase that's been approved by Institutional Review Board Services, according to CEO Barzin Bahardoust. The company has paid about 100 donors, so it can do quality testing and train staff at a site in downtown Toronto. There are plans to open another Toronto site as well as one in Hamilton, Ontario.
The Ontario Ministry of Health and Long-Term Care, Hemophilia Ontario, individual doctors and victims of tainted blood have expressed concern that paying for plasma poses risk to recipients and donors.
On July 22, Ontario's newly reelected Liberal government introduced a bill that would ban paying donors. Approval seems likely, given the Liberals hold a majority.
Those who oppose paying donors often cite the 1997 report from the Commission on the Blood System in Canada, which recommended that all blood and blood product donation be publicly administered and voluntarily donated after 1000 individuals contracted HIV and 33 000 contracted hepatitis C from blood products given by improperly screened donors.
But Canadian Blood Services and Health Canada say plasma from compensated donors, which is used for pharmaceutical therapies made from plasma protein not for direct transfusion, is safe.
"There are strict regulations in place which require screening and testing of all donors as well as the use of techniques to eliminate contaminates and viruses," says William Wells, media relations officer for Health Canada. Since the introduction of these processes, HIV, hepatitis C and hepatitis B have never been transmitted through the use of plasma pharmaceutical products from paid donors, adds Canadian Blood Services' CEO Dr. Graham Sher.
Stringent testing ensures that HIV, hepatitis C and hepatitis B are not transmitted through the use of plasma pharmaceutical products from paid donors, says Canadian Blood Services.
Image courtesy of Saritwuttisan/iStock/Thinkstock
It's against Canadian Blood Services' policy to pay for blood or blood products, but it would be impossible for Canada to meet its growing plasma need by relying solely on voluntary donors. Only 30% of the plasma-derived immunoglobulin is now supplied through the voluntary donor system; the rest is purchased from US companies that pay donors, says Sher.
Bahardoust says his company aims to discourage "people who are unsuitable" by paying not in cash but in their choice of a $25 charitable donation to Toronto's Hospital for Sick Children or a $25 Visa gift card that can't be converted to cash. Tests, like a physical exam, vitals testing and serum protein analysis are all done "for the safety of the donor."
Canadian Plasma Resources is not the first company to pay donors. Cangene, a Winnipeg-based pharmaceutical company, has been paying plasma donors for three decades. It was launched to collect Rh-negative plasma to treat pregnant women, but also collects plasma for pharmaceutical purposes.
Dr. Ryan Mieli, a Saskatoon-based family doctor and vice-chair of Canadian Doctors for Medicare, says that given the testing methods, he's not worried about the risks to recipients of paid-plasma derived pharmaceuticals, but he is concerned about risks to donors.
Speaking as an individual, not for his organization, Mieli says that given the locations of the clinics and the amount paid, Canadian Plasma Resources is "really targeting people who are low-income. They're profiting off of poverty … . I think that raises some significant ethical issues."
A review article in the Journal of Clinical Apheresis found that while adverse reactions to the donation of blood components were less frequent than with whole blood donation, the risk of reactions leading to hospitalization were greater in the former, and that the long-term effects of frequent blood component donation requires additional study. (Because the donor's red blood cells are returned after the plasma is separated out, donors can give plasma every week, while whole blood donors can give every eight weeks.)
Mieli says that "If we absolutely do have to pay people to get plasma, we should do it through Canadian Blood Services."
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We're now one step closer to being mauled by a giant robotic animal controlled by a nerdy warlord. Thanks to Boston Dynamics, with a funding assist from DARPA and the US Marines, for fueling my upcoming nightmares. Back in September we previously reported on the Legged Squad Supporter (LS3), which essentially a big, mechanical pack mule. Designed to carry 400 pounds of supplies over rough, uneven terrain, it is intended to serve as troop support, and as an additional power outlet for soldiers in the field.
Because of the planned use, LS3 requires a very specific set of skills. It must be able to remain stable on rugged ground, as well as be dexterous enough to maneuver through tight situations, in both urban and wilderness settings. Not an easy feat to accomplish, the Boston Dynamics folks are constantly working to improve on these abilities. Compare the first video to this new one, and you can definitely see the strides they've made in that regard. The prototype is much more nimble, and so much more surefooted on the unstable ground. Great, now it's even faster, has better traction, and is more nimble.
The LS3's follow-the-leader capacity also features more prominently in this video, specifically the new "follow tight" voice command. You see it responding to voice commands, selecting the best route, and even making decisions about where to go and which avenue to choose. You also get a glimpse at how it takes in data from it surroundings and interprets it. That's terrifying.
Seriously, it's like we want to at the hands of renegade robots that we created and then unleashed upon the world. Why do we keep making them better?
When the LS3 takes that tumble down a hill, it gets right back up again and keeps on truckin'. That means simply knocking it down won't stop it from coming after you. If we want to live through this one, we better start studying their weaknesses now.
LS3 does have a jaunty prance to its movement, which is pretty funny, but it won't seem quite so hilarious when it's prancing after you and your family with murder in its cold, robotic eyes.
Going to have to move alot faster before it can follow me through the woods.
Bobcat jumps out! LS3 fire flares. Now suppression fire on all oraganics besides me.


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text:
Minimum wage debate takes center stage tonight
By Tom Yazwinski
Courtesy: The Stand
SEATTLE -- Hundreds of people are expected to gather at Seattle Town Hall tonight to hold an open forum on the $15 minimum wage movement.
City council members and other city leaders will hear testimony from people who make the minimum wage or a little more.
Organizers expect workers in healthcare, retail, fast food and child care to sound off on the issue.
Tonight's event is at Seattle Town Hall at 1119 8th ave. from 6-10pm. Doors open at 5pm.
Kshama Sawant spoke at another open forum Tuesday morning on the campus of Seattle Central Community College.
Sawant said,"The workers themselves said I am fed up of living a life of poverty even after so much drudgery. I've had it. I'm gonna fight for it. And it's after thousands and tens of thousands and hundreds of thousands demand this and organize themselves into a cohesive movement that we start seeing change."
Sawant is expected to attend tonight's meeting.


text:
Labour Suffers Catastrophic Defeat in UK Election
On today's episode of Loud & Clear, Brian Becker and John Kiriakou are joined by Neil Clark, a journalist and broadcaster whose work has appeared in The Guardian, The Week, and Morning Star.
UK Prime Minister Boris Johnson's Conservative Party won British elections yesterday in the biggest landslide since 1987, guaranteeing that Brexit takes place on his terms next month. Labour Party leader Jeremy Corbyn said that he would not head the party in the next elections, but he has not yet set a resignation date. Meanwhile, the Scottish National Party won broadly, perhaps enough to push another referendum on Scottish independence.
The House Judiciary Committee this morning voted 23-17 in a party-line vote to impeach President Trump. The two articles of impeachment now go to the floor of the House, and the entire body will vote on impeachment on Wednesday. Ted Rall, an award-winning editorial cartoonist and columnist whose work is at www.rall.com, joins the show.
Earlier this week we told you about secret Pentagon documents uncovered by the Washington Post that show that the Defense Department, the CIA, and other federal agencies have lied consistently over the past 18 years about US military progress in Afghanistan. While the government was telling the American people that we were winning the war in Afghanistan, the truth was that we were losing, and in fact, we weren't even sure who the enemy was. Brian and John speak with Peter Kuznick, a professor of history and director of the Nuclear Studies Institute at American University and the co-author with Oliver Stone of the book and hit Showtime television series "The Untold History of the United States."
Israel appears headed toward a record third election in the past year after neither Prime Minister Benjamin Netanyahu nor his chief challenger, Benny Ganz, were able to form governments. The new election has been set for March 2. But this time, Netanyahu will have to campaign as a defendant in three criminal cases related to abuse of power and bribery. Miko Peled, the author of "The General's Son - A Journey of an Israeli in Palestine," and of "Injustice: The Story of the Holy Land Foundation Five," joins the show.
It's Friday! So it's time for the week's worst and most misleading headlines. Brian and John speak with Steve Patt, an independent journalist whose critiques of the mainstream media have been a feature of his site Left I on the News and on twitter @leftiblog, and Sputnik producer Nicole Roussell.
Friday is Loud & Clear's weekly hour-long segment The Week in Review, about the week in politics, policy, and international affairs. Today they focus on the impeachment hearings,US-China tensions and the UK election. Sputnik News analysts and producers Walter Smolarek and Nicole Roussell join the show.


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text:
【转载】Armv9: The Future of Specialized Compute
Arm CEO Simon Segars explains why the launch of the Armv9 architecture signals a new era for Arm and its partners.
By Simon Segars, Chief Executive Officer, Arm
One year ago, as Arm's global workforce began adjusting to remote working, we knew that technology would be key to weathering the storm.
Across the complex data-driven networks supporting all areas of the business world, we saw how technology enabled us to keep communicating and collaborating. The sudden switch to a digital-first life for Arm's 7,000 people was almost seamless, and we were all able to keep pushing our design and engineering efforts without much interruption.
Looking back, I'm hugely grateful for the resilience of our people, and our partners. Now, as we think about a return to working together face-to-face, we're once again considering how technology can speed our path back to shared physical workspaces.
The traditional workplace will evolve. Concepts such as thermal screening and the 'contactless office'—automating doors, light switches and other shared touchpoints so employees don't need to engage physically—are front of mind. Many of these systems will employ Arm technology in areas like automation and control and that's brought us into a conversation with Johnson Controls International (JCI), a company with more than a 100-years of experience in the building operations sector.
We're talking to JCI about how we see technology evolving, including the rise of advanced hardware security, on-device artificial intelligence (AI), sensor fusion and the flexible distribution of processing workloads from sensor to server.
The features that will enable this next generation of computing are already part of the Arm architecture but we are now enhancing our capabilities with the launch of our latest architectural design: Armv9.
The Armv9 Architecture: A milestone for Arm
The launch of the Armv9 architecture signals a new era for our company; a globally-pervasive platform driving secure AI-driven computing that will enable our ecosystem of more than 1,000 partners well into the 2030s. Armv9 will be at the forefront of the next 300 billion Arm-based chips; driven by the demand for increasingly specialized, secure and high performance processing built on the economics, design freedom and accessibility of general-purpose compute.
The Armv9 roadmap contains multiple new elements addressing the need for specialized compute from the smallest sensor to the largest supercomputer, but none are as important as the need to secure the world's data.
Armv9 addresses computing's greatest challenge: security
Hardware security isn't a given: A single vulnerability could compromise an entire network, and we face new attempts to exploit Arm technology every day. To get a sense for how pervasive the problem is, Symantec detected almost 19 million attacks on its Internet of Things (IoT) honeypots in the first quarter of 2020. That's a rate of more than 100 attacks per second, 13 percent higher than we saw towards the end of 2019.
In Armv9, we are introducing new features designed to deliver confidential computing – now an industry priority – at scale. Ordinarily, the operating system (OS) of a device has the highest authority and can see and do everything. Confidential compute changes that, and while the OS still decides what can run when, applications sit in a separate hardware-protected area of memory isolated from everything else in the system.
The Arm Confidential Compute Architecture (CCA) builds on the foundations of Arm TrustZone by enabling, for example, your personal banking information to be fully separated from your smartphone's social media applications. Arm CCA's new security features mean that even if a social media app did become infected with malware, it could not spread to the rest of your device.
Confidential compute is important for client devices, but it also has universal value as it keeps data encrypted while in transit, at rest, and isolated by the hardware while in use. In the cloud that can also mean protecting physical CPUs as well as virtualized processors running next to third party code.
In summary, confidential compute on Arm is a big deal. The security features we have developed already, and those we will create in future, will make their way across all tiers of computing applications; helping to protect IoT sensors, handsets, laptops, the Internet and the cloud.
Staying with security, the Arm Memory Tagging Extension (MTE) will be an integral part of the first generation Armv9-A based processors. Memory corruption is a major tool in a hacker's inventory: many well-publicized data security breaches of the past 30 years have resulted from exploiting vulnerabilities in how computers store and recall data from memory. If a hacker knows the location of an important string of data, they can overwrite it with malicious code.
MTE enables developers to lock strings of data using a 'tag'. That data can then only be accessed with the right key, held by the 'pointer'—the code that is tasked with calling data from memory. Implementing lock-and-key access is a huge step in securing not only the code but the data it processes.
Enhanced parallel compute with Scalable Vector Extension 2 for Armv9
We're also enhancing the performance of the v9 instruction set by upgrading our Scalable Vector Extension technology. SVE is already used in the Arm-based Fujitsu A64FX chip now powering the world's fastest supercomputer, Fugaku and the Isambard 2 Arm-based supercomputer housed at the UK's Meteorological Office.
Vectors, which are one-dimensional arrays of data, have been fundamental to high performance, energy-efficient computing since the world's first commercially successful supercomputer, the Cray-1 in 1976.
The more vectors a computer can handle in parallel, and the longer those vectors are, the more powerful the computer will be. In Armv8-A, as standard, vectors are 128 bits in length.
With Armv9's SVE2 upgrade, chip designers can choose a vector length in multiples of 128, up to 2048 bits. That's an enormous amount of parallel compute, and while SVE was initially developed for the HPC space, SVE2 in Armv9 extends SVE support for a range of specialized DSP and XR (augmented and virtual reality) workloads, from genomics to computer vision.
Armv9 Enables Advanced AI Applications
In Armv9, SVE2 also opens up a range of new approaches to deploying more powerful AI. And in the coming years, Arm AI-enabling technology will get a further boost through upgrades to Matrix Multiplication—a key element in enhancing machine learning (ML).
We've been pushing hard on the AI ability of our processors for several years and it's paved the way for a vast range of specialized applications and complex use cases.
In many cases, these will be cloud AI and edge AI use cases, making use of the incredible machine learning (ML) capabilities in our Neoverse infrastructure-class processors. But some of the most interesting use cases I've seen have been in endpoint AI—employing our smallest and lowest power Cortex-M processors.
Learn more: Cloud AI, Edge AI, Endpoint AI. What's the Difference?
Take a look at what Cambridge Consultants has been doing with our Cortex-M55 CPU and Arm Ethos-U55 microNPU, for example. The team not only ported the incredibly complex BacillAi cloud AI algorithm designed to monitor tuberculosis (TB) to the Cortex-M55 but they achieved similar run times and accuracy levels to the application's former cloud deployment – while drawing just a few Watts in the process.
And in Indonesia, conservationists working for Rainforest Connection have deployed Arm CPU and GPU-based devices to listen out for your command to listen for the tell-tale sounds of heavy plant machinery and chainsaws. The detectors run ML locally on the CPU using TensorFlow Light which makes them resilient to cellular network outages. They are also cloud-linked for data aggregation.
As Armv9 evolves, v9-M profiles will become available and they will enable a new wave of applications as I have described. Meanwhile, we're getting the developer world ready by providing advanced tool support and a model-based development platform so there's no lag between v9-based devices coming available and the ability of software developers to take advantage.
That includes the launch of virtual prototypes supporting SVE2 on our developer platform from the start of 2021, and the upstreaming of compiler support for SVE2 for GCC and LLVM. We're also providing a variety of C++ compiler support for intrinsics and auto-vectorization. These tools will enable the fast and easy porting of workloads to get them working on virtual v9-based targets.
There's a lot for Arm, and our partners, to get excited about with Armv9. But today's launch is just the first step on a roadmap of high performance, low-power IP that will spark the world's potential through specialized processing built on the economics, design freedom and accessibility advantages of Arm general-purpose compute.
Happiness Motivational Breakup Quotes
为nextcloud添加自己的注册邮件


We spend much of our lives searching for something that once was.
There are maps, guides, street views that are as ghostly as the very destination you may seek, the past is an unreliable path to the present.
Walking up Thornton Street North, through Village Park, a city green space initiative, now largely untended and unloved, you can clearly see where The Sparrow was.
A former estate pub, a footprint.
Away from the white hot heat epicentre of the Northern Powerhouse, you quickly feel the chill of deindustrialisation. Full employment and newly built social housing the stuff of dreams and folk memory, as the future is buried beneath worn lino and entrancing entrance steps, seemingly leading nowhere.


text:
Alfie in the Snow
Alfie series, Book 5
By: Rachel Wells
Narrated by: Edward Killingback
Length: 8 hrs and 1 min
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Publisher's Summary
Can Alfie and George save Christmas?
The Sunday Times best seller returns for a fifth book! Alfie and his mischievous kitten, George, are back for more adventures
When a new family moves onto Edgar Road, Alfie and George can't wait to welcome them - especially when they discover they have a cat, too!
Alfie imagines they'll be the perfect neighbours, but when one little misunderstanding gets blown out of proportion, the street is suddenly at war!
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Perfect for fans of A Street Cat Named Bob, Cathy Bramley and Holly Hepburn.
©2018 Rachel Wells (P)2018 HarperCollins Publishers
Series: Alfie, Book 5
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Alfie the Holiday Cat
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MicheleS
Cute feel-good story. Perfect for listening to while running errands etc. If you like Gwen Cooper's books, you'll like this author. :)
Alfie Once again Comes up Trumps.
I have the Audio version of this book as well as the Hardback copy. It is once again an excellent read, an emotional rollercoaster is one way of putting it. Alfie once again gets put in the thick of it. George saves the day on at least one occasion. Also particular around the middle of the book, a real tear jerker. If you like the ALFIE books then this is again a valued read from Rachel Wells. Edward Killingback Brings this audio book to life. Excellent.
Andrew Myers
Story of family & friends
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text:
Barbituráty (též barbiturany) jsou deriváty kyseliny barbiturové. Mají vysoký tlumící účinek na centrální nervovou soustavu.

Zhruba do poloviny 20. století byly hojně využívány jako léky na spaní, později byly pro své nežádoucí vedlejší účinky nahrazeny relativně bezpečnějšími benzodiazepiny. Na barbituráty si lze v poměrně krátké době vypěstovat silnou fyzickou a psychickou závislost, která může vést až k předávkování a smrti. Barbituráty bývají často využívány k sebevraždám.

Historie
Kyselina barbiturová byla objevena v roce 1864 německým vědcem Adolfem von Baeyerem, pozdějším nositelem Nobelovy ceny za chemii. Pojmenovány měly být podle jeho přítelkyně Barbary. Jiná verze však říká, že objev měl být dne 4. prosince, na den Sv. Barbory, a podle toho byla tedy látka pojmenována. První barbiturát, barbital, připravili Joseph von Mering a Hermann Emil Fischer. Brzy byly objeveny jeho sedativní účinky na pacienty. Roku 1903 se barbital začal prodávat pod názvem Veronal a používal se k léčbě nespavosti. Jako druhý následoval poměrně brzy fenobarbital (Luminal). V průběhu 20. století byly připraveny stovky barbiturátů a předepisovaly se po milionech. V 50. letech 20. století v USA lidé běžně užívali na spaní uklidňující barbituráty, načež si ráno brali stimulanty amfetaminy, aby se probrali. Postupně však byla spotřeba barbitátů radikálně omezena, zjistilo se, že barbituráty mají řadu vedlejších účinků. Na počátku 21. století se jich tak používalo již jen 12 druhů.

Za socialismu se v tehdejším Československu barbituráty a jiné léky zneužívaly více než dnes, zejména kvůli nedostatku jiných drog. V současné době jsou barbituráty jako hypnotika málo používané, a to kvůli snadnému vzniku tolerance, vysokému riziku závislosti a interakcích s jinými léky a alkoholem. Místo barbiturátů, tzv. první generace hypnotik, se využívají benzodiazepiny (druhá generace) nebo nebenzodiazepinová hypnotika, tzv. třetí generace hypnotik.

Působení
Barbituráty se váží na GABA receptory (receptory v mozku, které vážou kyselinu γ-aminomáselnou), konkrétně na třídu GABAA. Stejným způsobem působí i většina dalších sedativ, jmenovitě všechny benzodiazepiny.

Mají však řadu dlouhodobých vedlejších účinků. Snižují účinek kyseliny listové, snižují v těle hladinu vitamínů K, C nebo A, zvyšují citlivost na sluneční záření. Kombinace barbiturátů s alkoholem nebo opiáty může být smrtelná. Proto se na uklidnění opilých osob nesmí používat barbituráty. Mohou způsobit poruchy paměti, deprese, nechutenství, alergie (kožní vyrážky), potlačit vykašlávací reflex, způsobit náchylnost k infekcím hrudníku. Při náhlém vysazení se mohou objevit halucinace, třes rukou, pocity úzkosti, epileptické záchvaty. Na barbituráty snadno vzniká tolerance, a to na účinek a ne na toxicitu. Při delším užívání je tedy pro stejný účinek nutné zvyšovat dávky a tím se člověk přibližuje k toxickým dávkám. Při předávkování hrozí poškození dechového centra a selhání krevního oběhu.

Použití
Barbituráty se používají především jako sedativa a anestetika na operačním sále. Mimoto jsou stále v některých případech využívána jako antiepileptika, méně často jako hypnotika. Prakticky však znemožňují snový spánek – fáze REM se značně zkrátí. Jsou účinné také jako protijedy DDT, strychninu apod. V některých zemích se v kombinaci s dalšími léky používají k popravám injekcí nebo k euthanasii. Barbituráty můžeme podle délky působení rozdělit do tří skupin, které se navzájem překrývají:
 Krátce působící, 15 minut až několik hodin, např. sekobarbital, pentobarbital
 Střednědobě působící, v rozmezí několika hodin, např. amobarbital
 Dlouhodobě působící, v rozmezí několika desítek hodin (až 48 hodin), např. fenobarbital

Zneužívání
V šedesátých letech 20. století celá řada mladých lidí s barbituráty experimentovala jako s psychoaktivními látkami, neboť je generace jejich rodičů masivně využívala a byly tedy snadno dostupné. V roce 1970 byly barbituráty postaveny mimo zákon a jako bezpečnější alternativa byly propagovány benzodiazepiny. Uživatelé drog se brzy přeorientovali na jiné omamné látky. Jejich užívání má podobné účinky jako užívání alkoholu (dojem opilosti, zpomalená řeč, poruchy orientace), z dechu však není cítit alkohol.

Známé případy:
 Marilyn Monroe – zemřela na předávkování
 Brian Epstein – zemřel na předávkování
 Judy Garland – zemřela na předávkování
 Jack Kerouac – užíval
 Tennessee Williams - užíval, deriváty barbiturátů byly objeveny v jeho těle v den jeho smrti (udušení)
 Jimi Hendrix – zemřel na předávkování v kombinaci se zadušením
 Johnny Cash – užíval
 Elvis Presley – užíval
 Felix Hausdorff – spáchal sebevraždu předávkováním
 Edie Sedgwick – užívala a zemřela na předávkování
 Cesare Pavese – zemřel na předávkování

Odkazy

Reference

Literatura
 Trevor Stone, Gail Darlingtonová: Léky, drogy, jedy -

Externí odkazy

  Drogy-info.cz
  Tabulka škodlivosti drog - Drogy.net
  Medicina.cz

Sedativa
Antikonvulziva
Pyrimidiny
Anxiolytika

redpajama_set_name: RedPajamaWikipedia


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DRM technology provides distributed control of data to any device or users because all content in the record or document is encrypted securely. Even if sensitive information falls into the wrong hands, intruders will be unable to access them due to the layers of encryption in the DRM technology and services that power it. Moreover, if a user attempts to share protected data via email or copies it onto a pen drive, the permission rights in the DRM-protected document travel along with it ensuring it cannot be opened without permission.
DRM technology is a must for any organization that is looking to keep its data safe while stored on the cloud and at the same time while in transit to users. However, organizations that need to collaborate on classified documents must safeguard data after it has been shared. With a document DRM technology solution, controlled and secure collaboration can be made possible for an organization of any size. By pairing the DRM service with cloud storage and sharing solutions, organizations today can have end-to-end protection on their documents to share data securely.


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Richard Gere's critically overlooked masterpiece just premiered on Netflix and will keep you hooked for weeks
12/20/2022 admin critically, Geres, Hooked, masterpiece, Netflix, Overlooked, premiered, Richard, weeks
Life is a curious challenge. Although there are a thousand situations that seem to test our resistance the most, life presents itself to us in exactly the proportion that each one can bear it, but does not stop persuading, disrupting the most ordinary plans that we dream of. , runs violently over everything we can hold dear, imposes upon us a transcendent nature hovering over all that exists, of light and shadow, salvific and harmful, master of all that exists, surprising us even in the most intimate, details of ourselves that we thought were We knew this very well, which proved once more that he was always sure of the dominion he exercises over all his creatures. It takes some commitment to find the reason for so many obscure intentions, why we are thrown into abysses so deep and so inhabited by monsters that we ourselves cradle, when the belief that life is primarily a dream. But dreams seem to manifest themselves in a monstrous way, adding another almost insignificant piece to the infinite mosaic of the horrors of existence.
When a man lives and acquires some intimacy with life, he finds that the greatest pleasure of this divine and diabolical being, who is here too short or too long, is to yield to his whims, for which there is no real excuse in the world. He can never claim to know. Life passes, fortunately – only for this reason we can have some control over its unpredictable tricks, and it is still a great risk to think so – and leaves a trail of destruction that waters the stream of tears we shed, so many that they are a salt sea, as the poet sings. A convulsive cry, often exaggerated, but also a genuinely painful cry, sanctified by the pain that only hurts us (and how it hurts!), heals in the opening of deep wounds, heals in a moment of new grief, begins another cycle of bombs and debris. , until a broken soul takes a hit.
John Avnet talks about dreams like little else. There is a certain impulse in the director's work to try to get to know the dark alleys of the human mind, to identify possible explanations for the detours we insist on. In Três Cristos, Avnet maintains a kind of commitment to the viewer to delve into what his characters have to hide, putting everything on the table without the half-truths of other works that have made him internationally famous. The disturbing "Tomates Verdes Fritos" (1991) is an example that is far from unanimous. In a script that stands out for its emotion, beauty and multifaceted, complex approach to the types it portrays, the director and Eric Nazarian capture a less obvious side of madness, perhaps too romantic, but never frivolous.
Based on "The Three Christs of Ypsilanti" (1964), one of the bibles of the new psychotherapy, Avnet and Nazarian absorb its author's libertarian spirit – even the unruly – beyond the gifted view. surface. This trait, rare, can be apparent, especially in someone who chooses to make a living by digging into the brains of others, a decision that does not go unpunished. The town in southern Michigan that the Polish-American social psychologist Milton Rokic (1918-1988) mentions in the title of his book was home to one of the most vivid (and controversial) experiments in psychiatry. In 1959, three men who claimed to be none other than Jesus Christ began attending the same psychoanalysis session, while his mental illness was temporarily halted by strangulation and electric shock, Rokic took a twisted path that would indicate over the years that he It has no end, but whose progress can already be measured today, after more than six decades.
The trio of schizophrenics to which Avnet's film alludes – and interestingly, Rokic himself, misguidedly, calls himself the fourth "Christ" – arouses the interest of someone in history, which, by the way, has no didactic pretensions. Peter Dinklage's Joseph; Leon, played by Walton Goggins; Clyde, played by Bradley Whitford; And Richard Gere as Alan Stone, Rokic's alter ego, in one of his best performances, holds the attention of those who watch until the end as you realize why Stone loves what he does so much.
movie: Three Christs
direction: John Avnet
year: 2017 year
Note: 10
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text:
Q: Best way to build an SQL Update sentence from PHP I'm working on a project that require a profil in which people can modify their informations.
It's working but I was wondering : What is the best way to alter a line in a mysql database ? Should I modify value by value or update everything ?
Example :
Here I get what the current name and firstname are and I only update when it's different from what is currently on my database
Example 1 - Value by value
I made two query for each data if a change is made.
  if( (!empty($name)) && ($nom != $name_user) ){
    $sql = "UPDATE user SET name_user='$name' WHERE id_user='$id'";
    mysqli_query($conn, $sql);
    echo '
Your name has been modified
';
  }

  if( (!empty($firstname)) && ($firstname!= $firstname_user) ){
    $sql = "UPDATE user SET name_user='$name' WHERE id_user='$id'";
    mysqli_query($conn, $sql);
    echo '
Your firstname has been modified
';
  }

Exemple 2 - Everything in one query
It does the same but only with one query.
  if( ((!empty($firstname)) && ($firstname!= $firstname_user)) || ((!empty($firstname)) && ($firstname!= $firstname_user)) ){
    $sql = "UPDATE user SET name_user='$name', firstname_user='$firstname' WHERE id_user='$id'";
    mysqli_query($conn, $sql);
    echo '
Your profil has been modified
';
  }

Is it better to only update the value when it's actually change ? (example 1)
Is it better to change the two value even though only one was changed ? (example 2 )
What could be the best in performance ? Thank you !

A: Execute a single UPDATE to modify all necessary fields. There are several ways to build the sentence. This is a basic one:
$fields = array("field1", "field2", "field3");
$values = array();

foreach ($fields as $field)
{
    if (isset($_GET[$field]) AND !empty($_GET[$field]))
    {
        $values[$field] = "$field='"
                         . mysqli_real_escape_string($conn, $_GET[$field])
                         ."'";
    }
}
$sql = "UPDATE user SET " . implode (',', $values) . " WHERE id_user='$id'";
mysqli_query($conn, $sql);

Note: mysqli_real_escape_string() for escaping special chars. Details here.
Test it here.
Edited:
If security is a concern, seriously consider using Prepared Statements, as pointed in some comments.

A: The way I usually handle situations like this is by making the form names match the database field names, then I put a hidden field next to the visible input containing the old value with a modified name;
<input type="text" name="aboutme">
<input type="hidden" name="aboutme_old" value="<?= $aboutme ?>">
//$aboutme being the old value of the value to be changed

Then on the receiving PHP page use a foreach statement to run through a list of possible fields and create the statement needed.
<?php
//Set the fields to check
$fields = array ('firstname', 'secname', 'interests', 'aboutme');

//Start MYSQL query
$mysql_query = 'UPDATE `table` SET ';

$i = 0;
//Run through the list
foreach ($fields as $field) {
    $old_field = $field. '_old'; //Set to the old value input name
    $input = cleanInput($_POST[$field]); //cleanInput() is a made up function to check the data.
    if ($i != 0) $mysql_query =. ', '; //Check if you need a comma
    if ($_POST[$field] != $_POST[$old_field]) $mysql_query =. $field. ' = "' $input. '"';
    //Set the query if there is a change
    $i++;
}
?>

Make sure the data you are using is checked before you pass it through MYSQL otherwise you risk MYSQL Injection and thats just not good :)
A side note, this potentially would give information to an attacker if they realise your input names are the same as your DB field names.
But to test that they first have to make it into your DB, which shouldn't be a problem if you have all the relevant safeguards in place.
Best of luck

redpajama_set_name: RedPajamaStackExchange


To everyone who ever sold, bought, grew, sowed, harvested, grilled, ate, played, danced, and loved at the Occidental Bohemian Farmers Market, we thank you.
Every week, you inspired us to keep on hosting the best of Sonoma County's small farmers, delicious food producers, and handmade crafters. We spent every Friday of the summer running into old friends and making new ones, minute by joyous minute. We watched babies grow up and saw us all get a bit older, smiling widely along the way.
It's with a heavy heart that we announce we're closing after 17 seasons of operation in downtown Occidental. We're proud of the work we did together over those years and we're going to miss our time with you all more than you can know.
The demands placed on the market became insurmountable for our small group and inconsistent with our primary mission of serving farmers, but we're buoyed by the love and community that flourished on those summer nights. We're optimistic that someone, sometime will pick up the mantle and offer a home for all those who came together to celebrate food, friends, and the best our county has to offer.
Thanks again. For all of it. We'll never forget what we all shared.


ŠK Slovan Bratislava is a football club based in Bratislava, Slovakia, that plays in the Slovak Super League.
Founded in 1919, the club changed its name to Slovan Bratislava in 1953.
Slovan is the most successful team in Slovakia with the most titles in both league and cup in the country.
Slovan Bratislava became the first and so far only club in Slovakia as well as former Czechoslovakia to win one of the European cup competitions, the Cup Winners' Cup when they defeated FC Barcelona in the final in Basel in 1969.
The club also supplied seven players to the victorious UEFA Euro 1976 Czechoslovak team, which went on to win the tournament.
Maintaining a history of participating in top European competitions, SK Slovan now turns to North America.
ID Camps and tryouts will be held nation wide where the club will look to advance their international scouting department. The goal is to give players the opportunity to play at the highest level.


Barbecued Beef Brisket is one of the simplest things to make for a crowd and everyone loves it -- it can even be made ahead and frozen. Pair it with sides or build a killer sandwich!
Ever find yourself craving barbecue ribs but you can't get outdoors to your grill? Well, I have the perfect solution for you: oven-barbecue. The sauce is a snap to put together and the ribs will be fall off the bone tender.
This dish is a spin on the popular "beer can chicken" that many folks cook in their barbecue pits. You pour liquid into the inner well and set the bird on top, and it is continuously moistened while cooking. Every morsel will be incredibly juicy and you will never have to worry about a dried out turkey again.
These baby back ribs are super easy to prepare, and because they're cooked low and slow in the oven, they are fall-off-the-bone tender.
If you don't have time to soak the beans overnight, do a quick soak. Add the beans to a pot, cover with water, and bring to a boil. Remove from the heat and allow them to sit for 1 hour. Drain the beans, discard the liquid, and proceed with the recipe.
Here's an easy, quick, and delicious way to satisfy even the biggest brisket aficionado.


text:
Hong Kong Disneyland announces temporary closure amid new COVID-19 cases
Hong Kong Disneyland announces temporary closure amid new cases
HONG KONG -- Hong Kong Disneyland announced Monday that it is temporarily closing again one month after reopening to comply with the government's recently announced social distancing rules amid the ongoing coronavirus pandemic.
The new regulations limit gatherings, previously set at 50 people, to no more than four.
Hong Kong has seen over 100 new local cases this past week, after almost three weeks without a single case.
Last week, officials said one of the confirmed cases had visited the park and stayed at the resort before being diagnosed.
The Hong Kong Government said the measures will be in place for at least seven days and will be re-evaluated after a week.
The park will close on July 15, while the resort hotels will remain open with adjusted levels of services and enhanced health and safety measures that reflect the guidance of health and government authorities.
The Standard Day Ticket is valid for six months from the purchase date, and if needed, Hong Kong Disneyland Resort will assist in the refund for guests who have purchased tickets for admission to Hong Kong Disneyland park or have booked a resort hotel.
Magic Access membership validity dates will be extended based on the number of days the park is temporarily closed and according to the membership tiers.
Details will be communicated to members at a future time.
For the latest information about the resort, please visit HongKongDisneyland.com.
health & fitnessamusement parkdisneycoronavirusdisneylandcoronavirus pandemicu.s. & worldcovid 19 pandemiccovid 19 outbreakcovid 19


text:
Q: Remove elements from lists of a list in one column from a list in another column and replace with new values Python Pandas I have a dataframe (column del_lst has bool type ):
import pandas as pd

df = pd.DataFrame({'col1': [[['a1']], [['b1'], ['b2']], [['b1'], ['b2']], [['c1'], ['c2'], ['c3']], [['c1'], ['c2'], ['c3']], [['c1'], ['c2'], ['c3']]],
'col2': [['a1'], ['b1'], ['b2'], ['c1'], ['c2'], ['c3']],
'day': [18, 19, 19, 20, 20, 20],
'del_lst': [True, True, True , True, False, False]})
df

Output:
  col1                col2   day del_lst
0 [[a1]]                [a1]   18    True
1 [[b1], [b2]]        [b1]   19    True
2 [[b1], [b2]]        [b2]   19    True
3 [[c1], [c2], [c3]]  [c1]   20    True
4 [[c1], [c2], [c3]]  [c2]   20    False
5 [[c1], [c2], [c3]]  [c3]   20    False

I want to delete lists that have the True type, and delete them step by step. For example in [[b1],[b2]],b1 and b2 are True, so first delete b1, then b2. I did like this, but unfortunately my code doesn't work.
def func_del(df):
return list(set(df['col1']) - set(df['col2']))

def all_func(df):
# select only lines with True
df_tr = df[df['del_lst'] == True]
for i, row in df_tr.iterrows():
df_tr['new_col1'] = df_tr.apply(func_del, axis=1)

# I want to get a dictionary from where the key is column col1 and the value is new_col1
dict_replace = dict (zip(df_tr['col1'], df_tr['new_col1']))
# so that I replace the old values in the initial dataframe
df['col1_replaced'] = df['col1'].apply(lambda word: dict_replace.get(word, word))
return df

df_new = df.apply(all_func, axis=1)

I would like to have a dataframe like this at the end
   col1               col2  col1_replaced  day  del_lst
0 [[a1]]               [a1]   []             18     True
1 [[b1],[b2]]        [b1]   []             19     True
2 [[b1],[b2]]        [b2]   []             19     True
3 [[c1],[c2],[c3]]   [c1]   []             20     True
4 [[c1],[c2],[c3]]   [c2]   [[c2], [c3]]   20     False
5 [[c1],[c2],[c3]]   [c3]   [[c2], [c3]]   20     False

A: You need to loop here, using set operations:
S = set(df.loc[df['del_lst'], 'col2'].str[0])

df['col1_replaced'] = [[x for x in l
                        if (x[0] if isinstance(x, list) else x) not in S]
                       for l in df['col1']]

NB I am assuming that you have either single or nested lists here, if not just use if x[0] not in S as condition
output:
                 col1  col2  day  del_lst col1_replaced
0                [a1]  [a1]   18     True            []
1        [[b1], [b2]]  [b1]   19     True            []
2        [[b1], [b2]]  [b2]   19     True            []
3  [[c1], [c2], [c3]]  [c1]   20     True  [[c2], [c3]]
4  [[c1], [c2], [c3]]  [c2]   20    False  [[c2], [c3]]
5  [[c1], [c2], [c3]]  [c3]   20    False  [[c2], [c3]]


text:
Joanna Claustro / DMD
Recognized as Northern Virginia's best dentist, Dr. Joanna Claustro and her team provide expert care in all aspects of Cosmetic, Preventive, and TMJ Dental Care. Located in Ashburn, Virginia, we serve individuals and families in Loudoun and Fairfax Counties and are dedicated to helping you smile for years to come.
{ patient spotlight: Eden gordley }
Invisalgin & kor whitening, patient since 2013
{ meet eden }
Eden and her family have been patients of the practice for years and it has been so wonderful to watch her grow from a hopeful teenager to a confident, strong-minded young college student and model.
On her last visit home (during which she made it a priority to see her favorite dental team!), we were able to catch up and discuss how her smile has helped her feel more confident as she left home for the first time. This is what she had to share...
What made you decide to choose Invisalign and Kor Whitening?
Growing up, I've always wanted to have a nice straight smile. My smile wasn't terrible, but I had teeth that stuck out in different directions. It made me self-conscious. As I entered High School, I felt like my smile made me look like a kid. And I wanted to be taken more seriously. I was active in cheer and all I could see were my crooked teeth!
Dr. Claustro made me feel comfortable enough as a teenager to talk about my concerns and she told me about how quick and easy Invisalign would be. I liked [Invisalign] because the aligners were barely noticeable and I could still talk with them in. When I was done with the Invisalign (just in time for prom!), I used the Kor home whitening gel and I felt fabulous.
Has your "new smile" changed things for you?
Totally! I am so so happy with my smile! And I'm thankful for Dr. Claustro.
Now that I'm at VCU, I feel confident and ready to take on the world. My smile isn't a kid's smile anymore… It's mature, you know?
Are you still active with cheer in college? What's next for you?
I didn't commit to cheer during my freshman year because I wanted to focus on my classes and try new things. I'm trying to decide what is best for me and my future.
I've always been into beauty and makeup. I think everyone should feel pretty! I've started doing makeup for events and theater… kind of a small business venture. I have an Instagram feed for my work and I'm looking for more opportunities to do what I enjoy. I've also gotten into modeling, which has been a lot of fun!
I feel like, I am confident… how can I help others feel that way too?
We are so proud of Eden and her accomplishments! She remains a well-rounded and grounded young woman. We are thankful to have played a part in her transformation!
Before: Cute & Bubbly
After: Beautiful & Mature
{ dental profile }
Invisalign: 6 Months
Kor Take Home Whitening
6 Month Hygiene Visits
{ social profile }
Fashion & Lifestyle Model
How can we help you smile more?
Schedule Your New Patient Experience TODAY.
Joanna Claustro / DMD | Marblehead Office Park
20745 Williamsport Place, Suite 300 | Ashburn, VA 20147 | 703-406-8600


Sometimes the way to create great business relationships is by your word choices. The way we talk to people, especially potential clients, can adversely affect a relationship. But there are some key phrases to use to help you network and develop lasting career relationships.


text:
N News Blog
The End Of The JMI Foundation
LoveUnlimited Ministries	 13 July 2018
Now that does sets a dramatic tone, but it's a lot less dramatic then it sounds. Our ministry was officially founded in 2006, as Jaweh Online Ministries. In The Netherlands a ministry or charity organization can only register itself as a legal person, in the form of a foundation, which made the official name "Jaweh Online Ministries Foundation". In 2009 it became clear that the Lord didn't just wanted this ministry to be 'online', but also in a more practical way. Thus the official name was then changed to Jaweh Ministries International Foundation, or in short, the JMI Foundation.
Early 2014 we lost all our domains, which basically meant that we had to start all over again. At the time I decided to stop with everything, but for some reason received new strength to carry on. We decided to make that new start with a new name: LoveUnlimited. A name that is based on Ephesians 3, which talks about the width and length and depth and height of the love of God, which can be comprehended by revelation. From that moment this ministry unofficially became LoveUnlimited Ministries, while the official name remained the JMI Foundation, since an official name change would require a statutory change by the notary, before it can be changed at the Dutch Chamber of Commerce. An action we have pushed forward on the agenda for the last four years, until today.
As of today, the Jaweh Ministries International Foundation is no more, as the official name was changed by statutory change and became "LoveUnlimited Ministries Foundation". This means that LoveUnlimited is no longer a part of the JMI Foundation, but became the foundation itself. Other than the name, everything will remain the same, including our registration number, bank accounts etc.


AFW 581 Barbless Wet Fly hooks.
This is another Ahrex fly tying hook that I have been working with for several months tying and fishing wet flies.
Available in sizes that span the range from 4 to 10, I appreciate the wire, the barbless feature, the very slightly downturned eye, the finish, the curve the hook, and the overall proportion that enhances the finished flies I tie on this hook.