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Persistent Photoconductivity
Selenium would have been an uncommon material were it not for two electrical properties discovered in the very early days of electronics. The most useful of these is its ability to act as a type of rectifier called a metal rectifier. This rectifier action (changing alternating current to direct current) was discovered by Charles Fritts, circa 1886, but such rectifiers were only made practical in the 1930s.
The selenium rectifier elements, looking like the fins of today's semiconductor heat sinks (see photograph), were aluminum or steel plates, coated with a thin layer of bismuth or nickel, and then coated with a thick (~0.0025 inch) layer of selenium. Heat treatment ensured conversion of the selenium to its gray, hexagonal phase.
A selenium rectifier with inch square plates. Selenium rectifiers were common when I first started experimenting with electronics in the early 1960s.
(Photograph by Arnold Reinhold, viaWikimedia Commons.)
Each selenium element had a breakdown voltage of about twenty-five volts, but putting many in series gave a high voltage rectifier. Each selenium element had a voltage drop of about a volt, compared with about 0.7 volts for silicon rectifiers. Selenium rectifiers were useful for high current rectification, as for automotive battery chargers; but the voltage drop of multiple series connections, combined with the high current, resulted in a hot rectifier (up to 130°C) and a service life of about 50,000 hours.
The other useful property of selenium is its photoconductivity, which was discovered in 1873 by the English electrical engineer, Willoughby Smith. As often happens in science, this discovery was accidental. Smith was doing electrical measurements on submarine telegraph cables, and he found that the selenium resistance reference material he was using became more conductive upon exposure to light.[1]
Complementary to selenium's photoconductivity was the 1877 discovery of the photovoltaic effect in selenium by W.G. Adams and R.E. Day.[2] Charles Fritts used this effect to make a selenium-gold solar cell in 1883.[3] This solar cell had less than 1% efficiency, but it was an innovation, nonetheless. The best photovoltaic cells of today have better than 35% efficiency, but residential panels have far less than that.
Selenium's photoconductivity was crucial to the 1938 invention of Xerography by Chester Carlson. Carlson found that a plate coated with "cuprous oxide or the metallic variety of selenium," would lose charge in the areas exposed to light. Thus, an image of a printed page would still have charge at the black letters, and none from the white background sheet. A fine, black powder, sticking to the charged surface, would form a copy of the image.[4]
The photoconductivity of selenium was a surprise, and you would think that few such surprises would still exist for simple materials. Strontium titanate (SrTiO3) was first synthesized by Leon Merker at the National Lead Company, and a process for its synthesis was patented by Merker in 1956.[5] Now, more than fifty years later, physicists at Washington State University (Pullman, Washington) have discovered persistent photoconductivity in strontium titanate.[6-8]
Persistent photoconductivity means that shining a light on the material increases the conductivity not just for the period of light exposure, but for a significant time thereafter. In the case of strontium titanate, this time period is many days, which means that it would be possible to make an optical memory device using this effect.[7]
Mounting a strontium titanate specimen (white square) for measurement.
(Still image from a YouTube video.[8]
Washington State University doctoral student, Marianne Tarun, discovered the effect. A research team comprised of Tarun, fellow student, Farida Selim, now at Bowling Green State University, and professor Matthew McCluskey, found through experiments that the effect was not from some dopant, but it was an effect of light on pure strontium titanate.[7] Said Tarun, "It came by accident... It's not something we expected. That makes it very exciting to share."[7]
Exposing strontium titanate at room temperature to light energy at its intrinsic bandgap of 2.9 eV or higher increases the free-electron concentration by more than two orders of magnitude.[6] The conductivity jumps by a factor of 400, albeit from a low initial level.[7]
The higher conductivity remains for days with negligible decay, and the authors speculate that the persistent photoconductivity is due to excitation of electrons from a titanium vacancy defect to the conduction band, with subsequent electron recapture by the vacancy having a very low probability.[6]
Measuring photoconductivity of a strontium titanate specimen.
Says paper co-author, Matthew McCluskey, alluding to the possibility of using strontium titanate as a holographic memory,
"The discovery of this effect at room temperature opens up new possibilities for practical devices. In standard computer memory, information is stored on the surface of a computer chip or hard drive. A device using persistent photoconductivity, however, could store information throughout the entire volume of a crystal."[7]
The Washington State University research was funded by the National Science Foundation.[7]
"Effect of Light on Selenium during the passage of an Electric Current" (W. Smith), Nature, vol. 7, no. 173 (February 20, 1873), pp. 303-303.
W. G. Adams and R. E. Day, "The Action of Light on Selenium," Proc. R. Soc. Lond., vol. 25 (January 1, 1876), pp. 113-117, doi:10.1098/rspl.1876.0024 (PDF File).
C. E. Fritts, "On a new form of selenium cell, and some electrical discoveries made by its use," American Journal of Science, vol. 26, series 3 (December, 1883), pp. 465-472.
Chester F Carlson, "Electrophotography," US Patent No. 2,297,691, October 6, 1942.
Leon Merker, "Refractive material," US Patent No. 2,764,490, September 25, 1956.
Farida A. Selim and Matthew D. McCluskey, "Persistent Photoconductivity in Strontium Titanate," Physical Review Letters, vol. 111, no. 18 (November 1, 2013), Document No. 187403 [5 pages].
Accidental discovery dramatically improves conductivity, Washington State University Press Release, November 14, 2013.
Washington State University, "Accidental Discovery Dramatically Improves Electrical Conductivity," YouTube Video, November 15, 2013.
Linked Keywords: Selenium; material; electricity; electrical; electronics; selenium rectifier; metal rectifier; alternating current; direct current; Charles Fritts; 1930s; semiconductor; heat sink; aluminum; steel; bismuth; nickel; inch; heat treating; Heat treatment; hexagonal crystal system; hexagonal phase; Wikimedia Commons; breakdown voltage; volt; voltage drop; diode; silicon rectifier; automobile; automotive; battery charger; series circuit; series connection; Celsius; C; service life; photoconductivity; English; electrical engineer; Willoughby Smith; science; serendipity; accidental; submarine telegraph cable; electrical conductivity; conductive; light; photovoltaic effect; Charles Fritts; gold; solar cell; efficiency; Xerography; Chester Carlson; cuprous oxide; electric charge; Coulomb's law; electrostatic attraction; strontium titanate; chemical synthesis; NL Industries; National Lead Company; physicist; Washington State University (Pullman, Washington); optics; optical; computer memory device; YouTube video; Doctor of Philosophy; doctoral student; >Marianne Tarun; Farida Selim; Bowling Green State University; professor; Matthew McCluskey; experiment; dopant; intrinsic semiconductor; room temperature; radiant energy; light energy; electronvolt; eV; free-electron; orders of magnitude; electron; titanium; vacancy defect; conduction band; probability; holographic data storage; holographic memory; National Science Foundation; Chester F Carlson, "Electrophotography," US Patent No. 2,297,691, October 6, 1942; Leon Merker, "Refractive material," US Patent No. 2,764,490, September 25, 1956.


Buddy Hield: He's physically and mentally mature, which isn't always the case with rookies. And he'll get a lot of shots with the New Orleans Pelicans.
Hassan Whiteside: The Miami center (and Gastonia native) is an explosive shot-blocker and grabs rebounds by the dozens. He has to be great in order for the Heat to contend with Dwyane Wade and Chris Bosh gone.
D'Angelo Russell: With Kobe Bryant retired, the Los Angeles Lakers are basically Russell's team now. He'll put up big numbers on a bad team.
Andre Iguodala: He's comfortable either coming off the bench or starting at this point. He'll get plenty of exposure, with the Warriors on national television constantly.
Tom Thibodeau: One of the NBA's great defensive minds, Thibodeau has a driven work ethic. He inherits a great young roster in Minneapolis.


In February 2009, 733 pieces from Pierre Bergé?s and Yves Saint Laurent?s art collection one of the world?s largest private collections was auctioned off in a record-breaking sale of the century.
Modern paintings, baroque bronzes, antique silverware, statues, cameos, and minerals comprise this diverse collection that furnished the pair?s two luxurious residences in Paris, and included major works by Picasso, Brancusi, Matisse, Mondrian, in addition to furniture by the Art Deco masters Eileen Gray and Jean Dunand. Many works sold for prices far exceeding the highest estimates.
The five-volume catalog published by Christie?s for the event sold out before the end of the auction, leaving collectors and art connoisseurs the world over empty-handed.
This new book features one hundred of the most important pieces from the collection with detailed commentary by Christie?s experts.
An introduction by Christie?s vice president François de Ricqlès revisits the intense three-day auction at the Grand Palais.
An appendix includes images of the works sold, accompanied by their estimated values and final auction prices.
Publication coincides with the auction of the collection from their Château Gabriel property in November 2009.


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A Leadership Team in an Augustinian School engages in a process of collaboration and collegiality in manners pertaining to the school community. The assumption is that each member of the team has a valued perspective and is genuinely invested in the endeavor which maximizes the efforts of others - faculty, staff, and students, toward the achievement of a greater good, namely, the education of the whole person: mind, body, and spirit. Leadership involves establishing a clear vision, sharing that vision with others and providing the information, knowledge, and methods to realize that vision.
Joining Fr. Reilly on the Leadership Team are the following members of our community.
Trustee Emeriti
Rev. Donald F. Reilly, O.S.A.
Fr. Reilly began his term as Head of School at Malvern Preparatory School on July 1, 2017. Prior to his role at Malvern, Father was President of St. Augustine Preparatory School. He served as the Prior Provincial of the Province of St. Thomas of Villanova from June 2002 to June 2010 and has an extensive background in education, theological studies, and Institutional Advancement.
Fr. Reilly has provided board leadership to Villanova University and Merrimack College and currently serves on Malvern's board. Fr. Reilly has served on the Member's Cooperation and as Chair of the Prep's Board of Directors for eight years. He is a co-founder of Siloam Ministries in Philadelphia and has been involved in numerous international projects focused on support for the Augustinian ministries. Father has been recognized for his work, including the Faithful Servant Award from St. Patrick's College, the Urban Angel Award from the New York Theological Seminary, and an honorary doctorate in Augustinian Education from Merrimack College.
Ms. Beth Alfonsi
Ms. Alfonsi is the Executive Director of Advancement and her role is to work closely and collaboratively with the Admissions, Development, and Marketing teams.
Mr. Ronald Algeo '87 P'15
Assistant Head of School for Student Leadership
Mr. Algeo ensures a positive and fulfilling student experience outside of the classroom. He oversees and works collaboratively with Athletics, Discipline, School Counseling, Student Life, and Summer and Orientation Programs to ensure student engagement, social development, and overall leadership growth for each of our students.
Mr. Theodore N. Caniglia, Jr. P'03
Director of Financial Affairs
Mr. Caniglia ensures the fiscal health and physical well being of our school by serving as the chief financial and facilities officer. He oversees the operations of our Business Office, Maintenance Department, Dining Hall, Bookstore, Security, and Malvern Swimming Association (MSA) programs.
Rev. Christopher J. Drennen, O.S.A '73
Director of Mission and Ministry
Fr. Drennen oversees the spiritual development of our students, faculty, staff, and parents. He manages Campus Ministry, Christian Service, and the Theology Curriculum to ensure a consistent and fully integrated approach to our Catholic, Augustinian teachings and our Christian Service learning programs.
Mrs. Neha P. Morrison P'24
Director of Human Relations
Mrs. Morrison guides the management of the overall Human Resources policies and programs for our entire community. She is responsible for providing, with the support of appropriate colleagues and external experts, the successful delivery of HR services, while also monitoring the effectiveness of Malvern's inclusive culture, diversity, and engagement programs.
Mr. G. Patrick Sillup
Assistant Head of School for Academics
Leading the academy model approach to academics, Mr. Sillup ensures the continued evolution of our team-based, innovative, student-centered learning program. He works closely with the Academy Leaders, the Dean of Faculty Coaching and Development, the Curriculum Coordinators, the Technology Department, and the College Guidance Office to provide an engaging and experiential learning experience for each of our students.
Ms. Danielle Suber
Director of Diversity, Equity & Inclusion
Ms. Danielle Suber is the Director of Diversity, Equity and Inclusion at Malvern Preparatory School. She holds a Bachelor of Arts from Notre Dame of Maryland University in Communication Arts with minors in Advertising and Public Relations. Danielle is also the President and one of the founding members of Higher Level Consulting, LLC; a non profit organization that helps mentor students of color in their post secondary plans. In her spare time, she volunteers at her church, Shiloh Baptist Church in York, PA. She also works with various community and non-profit organizations in the area educating underrepresented students on the importance of post secondary education as well as diversity, equity and inclusion educational opportunities.
2020-2021 Board Leadership
Mr. John F. McGlinn II P'14'16'18, Chairman
Mr. Joseph H. Davis, Ph.D. '90 P'21, Vice Chair & Treasurer
Moira A. Murphy, Esq. P'11'14, Secretary
Archbrook Capital Management
Advancement Committee, Audit & Risk Committee, Augustinian Mission Committee, Committee on Trustees, Executive Committee, Facilities Committee, Finance Committee, Investment Committee, Head of School Support & Evaluation Committee
Mr. McGlinn is a Founding Partner of Archbrook Capital Management LLC, an investment firm based in West Conshohocken, PA. Archbrook holds investments in several small-to-mid-sized companies and Mr. McGlinn serves as a board member on most of those investments. Primary responsibilities include Tray-Pak Corporation, Reading, PA; Argus Staffing in Denver, CO; and Alexin LLC in Bluffton, IN. Mr. McGlinn received an MBA from the University of North Carolina and a Bachelor's degree in Business Administration from the University of Notre Dame.
John and his wife, Melissa, have served as members of the Advisory Board for the Alliance for Catholic Education at the University of Notre Dame since 2012. Their three sons have attended Malvern (Dan '14; Tait '16; Johnny '18) and have been active members of the student community. Their daughter Kelly attends Academy of Notre Dame. The McGlinns are active members of St. Norbert's Parish in Paoli, PA enjoy traveling together and spending time at their lake home.
Global Chief Economist & Head of the Investment Strategy Group
Audit & Risk Committee, Executive Committee, Finance Committee, Investment Committee, Head of School Support & Evaluation Committee
Mr. Joseph H. Davis is the Global Chief Economist & Head of Investment Strategy Group for Vanguard. His previous roles with Vanguard include Principal, Chief Economist, and Investment Analyst. Prior to working at Vanguard, Mr. Davis was an Economist with Moody's Economy.com. Mr. Davis' area of expertise includes macroeconomics, asset allocation strategies, fixed income strategies, portfolio management, financial simulation, alternative investments, asset-class modeling, public speaking, and economic history.
Mr. Davis also volunteers with the United Way, serving as a fundraiser and participating in the Day of Caring activities.
Legacy Coach
Augustinian Mission Committee, Executive Committee, Head of School Support & Evaluation Committee
Mrs. Moira Murphy, Esq. is currently self-employed as a legacy coach, partnering with individuals and families as they seek to align their living and giving with their values, passions, and dreams for a better world. Previously she served as the Stewardship Development Coordinator at St. Norbert's Parish (Paoli, Pa.), where she continues to volunteer in a variety of roles. She is the retired General Counsel, Mid-Atlantic Region of Mellon Financial Corporation, where she worked for 18 years as a consumer banking attorney.
Mrs. Murphy resides in Malvern with her husband and enjoys visits from her two sons.
Mr. Miguel Alban P'23'27
Mr. Joseph L. Carlini P'13'10
Mrs. Marissa Cherian P'22
Mr. Louis B. Colameco III '77
Mr. Ben Davis '95 P'24
Rev. Louis DelFra, CSC '88
Rev. Michael F. DiGregorio, O.S.A.
Rev. Peter M. Donohue, O.S.A., Ph.D.
Ms. Kathleen E. Duffy
Mr. David Frank '91 P'20
Louis Giangiulio, M.D. '86 P'21
Rev. Rob Hagan, O.S.A.
Mrs. Shonda Little P'23
Mr. Joseph J. McLaughlin, Jr. P'12'14'18
Mr. Brian McTear '93 P'24'25'25
Mr. Stephen G. Meyer P'17
Rev. Robert J. Murray, O.S.A.
Mrs. Katherine Richman Oates P'18
Rev. James D. Paradis, O.S.A., D.Min.
Rev. Donald F. Reilly, O.S.A., D.Min.
Mr. Brian J. Riley P'21
Sister Stephen Anne Roderiguez, IHM, Ed.D.
Mr. Kevin J. Traynor, Jr. '86 P'14'16'18'21'22
Senior Vice President, Director of Multicultural Banking
Mr. Alban also serves as the Honorary Consul of Peru in Philadelphia and Vice President of the Consular Corps Association of Philadelphia. Mr. Alban earned his Law degree from the University of Piura, Peru and is a lawyer in Peru. He earned his Master's Degree in International Law from Temple University's Beasley School of Law and he is a Graduate from the University of Pennsylvania's Wharton School of Business, Stonier School of Banking.
Prior to Customers Bank, Mr. Alban served as a Vice President of Multicultural Banking for Bryn Mawr Trust and has also served as Director of Hispanic Banking for Susquehanna Bank (Former First National Bank of Chester County). Mr. Alban was the Founder of The Hispanic Approach and the Hola Magazines, marketing agencies focused on multicultural markets.
Mr. Alban currently serves and has served as a board member for many organizations across the greater Philadelphia region, including: Congreso de Latinos Unidos, the YMCA of the Greater Brandywine, Baker Industries, Southern Chester County Chamber of Commerce, and La Comunidad Hispana.
Mr. Alban was the recipient of the "40 under 40' award in 2020 by the Philadelphia Business Journal and the "Thanks for Caring" award in 2014 for his community involvement and numerous contributions by the Chester County Community Foundation.
Mr. Alban has been an Adjunct Professor of Spanish at several Philadelphia-area Universities, including Villanova University, Cabrini University, and Immaculata University.
He currently resides in Malvern with his wife and three children.
Chairman of the Board and Chief Executive Officer
McKean Defense Group, Inc.
Advancement Committee, Executive Committee, Finance Committee, Head of School Support & Evaluation Committee
Mr. Joseph L. Carlini is the Chief Executive Officer and Chairman of the Board of McKean Defense, an engineering and technology solutions firm that provides life cycle engineering, sustainment, and modernization support and information technology/enterprise transformation services to the U.S. Navy and other federal customers. Prior to his current position, Mr. Carlini was a Group Senior Vice President for Science Application International Corporation (SAIC), managing the $1 billion Naval Engineering and Technology Solutions Group.
Mr. Carlini is on the Board of Directors of CDI Corporation, the Philadelphia Police Foundation, and the Philadelphia Police Athletic League. He also serves on the Board of Trustees for the Catholic University of America and is a member of the American Society of Naval Engineers, and the Surface Navy Association. He currently resides in Malvern with his wife and their four children.
Marissa Cherian, LLC
Committee on Trustees
Mrs. Marissa Cherian is an executive coach and trusted advisor to leaders. Driven by a passion to help individuals and organizations thrive, she works closely with senior executives and private equity partners to maximize individual growth and organizational performance.
She has two decades of experience as a talent management professional – both as a management consultant and leader of recruiting and professional development teams. Previously, she led talent acquisition for Accenture's Management Consulting business globally as well as the Northeast Office of McKinsey & Company, where she launched her management consulting career. A Summa Cum Laude graduate of Lehigh University, Mrs. Cherian earned a MBA from the University of Pennsylvania's Wharton School of Business, where she was one of 12 Leadership Fellows.
Mrs. Cherian served on the Academic Innovation Sub-Committee for Malvern Preparatory School, while also sitting on the Board of Trustees at Waldron Mercy Academy. She also serves on the advisory boards of both Catie's Wish Foundation and Compass Philadelphia, whose mission is to inspire the active engagement of business professionals with their local non-profits to transform communities. Mrs. Cherian lives in Ardmore with her husband and their two children.
Colameco Brothers, Inc.
Mr. Louis B. Colameco III is the founder and former President of Wellshire Family of All Natural Products (1996-2018). The company is the largest further processor of smoked and cooked meats to Whole Foods Market. Wellshire Inc, along with its five other brands, is one of the largest all-natural meat companies in North America. In 2010, Mr. Colameco was named Gloucester County Chamber of Commerce's Business Person of the Year. A graduate of Malvern Prep, Mr. Colameco was honored by Malvern Preparatory School, receiving the Alumni Loyalty Award and the St. Augustine Alumni Award, in 2007 and 2011, respectively. In 2016, he and his wife Ginny were honored by the Pathway School with its Apple Award.
Mr. Colameco spends his time serving on many academic and charitable advisory boards. Since 2009, he has served on the Board of Goodwill Industries of Southern NJ and Philadelphia, serving as Chairman from 2016 to 2018. Mr. Colameco has just been named to the Integrative Medicine advisory council for Thomas Jefferson University School of Medicine. He has founded many academic scholarships including The Wellshire/Colameco Family Scholarship at Malvern Prep, The Wellshire/Colameco Family Scholarship at St. Edmund's Academy, The Barbara A. Colameco Scholarship at Gloucester County, NJ's 4H Club. One of his proudest accomplishments has been the formation of The Barbara A. Colameco Cancer Transportation Fund, which has helped countless people on their "Ride to Remission." To date, the Fund has raised over $1,000,000 and has provided over 50,000 rides to individuals in need of transportation to their treatment appointments.
Philadelphia Phillies Color Commentator
Comcast Spectacor
Mr. Ben Davis works for Comcast Spectacor in Philadelphia as the Philadelphia Phillies Color Commentator.
From 1998 to 2005 he was a major league base; however, his baseball career lasted over 16 years. Mr. Davis retired from professional baseball in 2010 after playing for the San Diego Padres, Seattle Mariners, and Chicago White Sox.
Mr. Davis and his wife Megan have four children, two boys and two girls. Mr. Davis has a son in the Class of 2024.
Chairman of the Board, Faculty Member, Director of Pastoral Life
University of Notre Dame's Alliance for Catholic Education (ACE)
Advancement Committee
Rev. Louis A. DelFra, C.S.C., serves as the Chairman of the Board, as well as a faculty member and Director of Pastoral Life, for the University of Notre Dame's Alliance for Catholic Education (ACE). ACE is a national, and increasingly international, K-12 Catholic school teacher training M.Ed. program that places recent highly talented college graduates in under-resourced K-12 Catholic schools around the country.
A 1988 graduate of Malvern Prep, he returned to Malvern as a teacher and coach in both the Middle School and High School from 1992-1995. He then returned to the University of Notre Dame, where he entered the Congregation of Holy Cross and was ordained a priest in 2004. He currently publishes in the fields of teacher education, Catholic character in K-12 Catholic schools, and the spirituality and vocation of teaching. He gives retreats and workshops throughout the country on the intersection of faith and education, including "Creating a Catholic School Culture on the Pillars of Discipleship, Community, and Prayer." His publications include, "Teaching Theology through Literature: A Justification and Proposed Curriculum for Teachers" in Catholic Education: A Journal in Inquiry and Practice, as well as a popular series of daily spiritual reflections for teachers, 5 Minutes with Christ; 5 Minutes with Saints; and 5 Minutes with the Psalms: Spiritual Nourishment for Busy Teachers. He is the recipient of the University of Notre Dame's William A. Toohey Award for Preaching.
Prior Provincial
The Augustinian Order
On Monday, June 9, 2014, Augustinians of the Province of St. Thomas of Villanova, along with family, friends, and benefactors, witnessed as Father Michael F. DiGregorio, O.S.A. was installed as the 39th Prior Provincial of the Province of St. Thomas of Villanova. Alejandro Moral Anton, O.S.A., Prior General of the Order of St. Augustine, presided over the Mass of Installation at St. Thomas of Villanova Church, Villanova, PA. Fr. Michael, the former Vicar General of the Augustinian Order, completed his term in September of 2013 and was elected on February 7, 2014, to succeed Anthony M. Genovese, O.S.A. as Prior Provincial. The June 9th Installation began Fr. Michael's four-year term as Prior Provincial.
As Vicar General and a member of the General Council of the Order of the General Council of the Order, Fr. Michael worked at the General Curia of the Order in Rome from 2007 to 2013. Prior to his election to the General Curia, Fr. Michael was assigned to parishes in Philadelphia, New York, and Massachusetts. He directed novice and pre-novice formation programs in Massachusetts and Pennsylvania. In 1990, he was assigned to the General Curia of the Order in Rome as the Director of Communications for the Order. In 1992, he returned to the U.S. and was assigned as the Director of the National Shrine of Saint Rita of Cascia in Philadelphia, PA. In 1995 he was named Pastor of St. Rita's as well.
Committee on Trustees, Facilities Committee
Rev. Peter Donohue serves as the President of Villanova University, located in Radnor, Pa. Father Donohue has a rich background in education and theatre and served as the University's Chair of the Theatre Department from 1992 to 2006. He annually directed musical theatre productions on campus, earning six Barrymore Award nominations and one Barrymore Award for Outstanding Direction of a Musical from the Theatre Alliance of Greater Philadelphia.
Father Donohue serves on the Board of Trustees for Villanova University, Merrimack College, Malvern Preparatory School, St. Augustine Preparatory School, the Greater Chamber of Commerce, the Association of Catholic College and Universities and the Association of Independent College and Universities in Pennsylvania. Father Donohue currently resides in Radnor, Pa. will the Augustinian Order.
Independence Wealth Advisors, Inc.
Ms. Kathleen Duffy serves as the Chief Compliance Officer with Independence Wealth Advisors, Inc. Ms. Duffy has held her current position since January 2007. Prior to her current job she was a Financial Advisor affiliated with Ameriprise. Ms. Duffy has held the designation of Chartered Financial Consultant (ChFC) since August 1, 2003. She has also been a Certified Financial Planner since June 1, 2004.
Mr. David Frank is the Managing Director for Marsh's Mid-Atlantic Region. He manages a new business budget for Marsh's Mid-Atlantic Region of $30 million. Mr. Frank is responsible for ensuring the appropriate Marsh resources, services and solutions are identified and deployed to both clients and prospects. He has been with Marsh since 1997. Prior to his current role at Marsh, Mr. Frank was responsible for the development and execution of Marsh's growth strategy (2007-2011) and leading the Marsh office in San Diego, Ca. (2004-2006).
Mr. Frank was the Malvern Prep Alumni Board President from 2012-2015, serves on the board for the Philadelphia Chapter of The National Association of Corporate Directors and sits on the Board of Governors at St. Joseph's University Academy of Risk Management and Insurance. He resides in East Goshen with his wife and three children.
Sugartown Pediatrics
Dr. Giangiulio is the primary doctor and founder of Sugartown Pediatrics. He is credentialed at Main Line Health and attends to newborns at Paoli, Bryn Mawr, and Lankenau Hospitals. He is also on staff at Women's Lifecycle Care Birthing Center (Bryn Mawr), is the school physician at The Phelps School (Malvern), and serves as a medical consultant for the Penn-Delco School District and the wrestling program at Malvern Preparatory School.
Dr. Giangiulio served as an Army pediatrician for six years, including a nine month tour in Afghanistan in support of Operation Enduring Freedom. He completed his undergraduate studies at Johns Hopkins University, received his medical degree from Jefferson Medical College, and completed his residency in Pediatrics in the U.S. Army at Walter Reed AMC in Washington, D.C. and Bethesda Naval Medical Center.
Dr. Giangiulio serves on the Main Line Health nursery committe and is a member of the board at the Mason Shaffer Foundation.
Senior Associate Athletics for Student-Athlete Welfare
Advancement Committee, Executive Committee, Head of School Support & Evaluation Committee
Rev. Rob Hagan serves as the Senior Associate Athletics for Student-Athlete Welfare at Villanova University. As part of this role, Father Rob oversees the areas of Sports Medicine and Strength and Conditioning, as well as the administrator for the golf program, and serving as the chaplain for the Villanova men's basketball and football teams. Prior to his current role at Villanova, Father Rob was the Assistant Athletic Director for Compliance.
Father Rob graduated from Villanova with a Bachelors of Arts in 1987. He earned a J.D. from Widener University School of Law in 1990 and spent seven years as an attorney with Gillin and Associates, where he also served as Criminal Defense Counsel. He also served as assistant counsel to the Solicitor for the Delaware County Solid Waste Authority and the Delaware County Register of Wills.
Father Rob entered the Order of St. Augustine in 1997. He served as Chaplain at Thomas Jefferson University Hospital in Philadelphia and at the University of Maryland, College Park, and received a Masters in Theology from the Washington Theological Union in 2003. He is a past member of the Pennsylvania Bar Association, the Delaware County Bar Association, and the Delaware County Association of Criminal Defense Attorneys.
Director, Clinical Project Scientist Leader
Johnson & Johnson/Janssen Oncology
Mrs. Shonda Little, a West Philadelphia native, was educated in the Philadelphia parochial and public-school system. After graduating from the nationally-ranked Central High School of Philadelphia, Mrs. Little attended The University of Pennsylvania on a full academic scholarship as a Mayor's Scholar, where she earned an undergraduate degree in neuroscience. She later earned a graduate degree in cancer epidemiology from Drexel University School of Public Health. Additionally, she is a Certified Personal and Executive Coach.
Mrs. Little has over 20 years of pharmaceutical industry experience in clinical research and development. As a Lead Scientist, she has successfully led the development of several oncology drugs resulting in accelerated approval from FDA and EMA. She has co-authored numerous scientific publications and collaborated with top cancer researchers around the world. Mrs. Little currently works at Johnson & Johnson/Janssen Oncology as a Director, Clinical Project Scientist Leader where she leads a team of clinical scientists developing new drugs for the treatment of advanced solid tumors. Outside of work, Mrs. Little gives back to the community as an Executive Board Member of the Chester County Chapter of Jack and Jill of America, Inc. In her role as Program Director, she leads the planning of educational, civic, and cultural activities for the organization.
Haverford Trust Company
Finance Committee, Investment Committee
Mr. Joseph McLaughlin is the Chairman and CEO of Haverford Trust Company. He has been with the company since 2002 and worked in the investment industry since 1984. Previously, he was Vice President of J.P. Morgan and Company and a Certified Public Accountant/Manager at Peat, Marwick, Mitchell and Co.
He serves on Haverford Trust's Board of Directors, is a member of the Executive Committee and a voting member of the Investment Selection Committee. He also serves as the Vice Chairman on the Board of Trustees for the Paoli Memorial Hospital Foundation, sits on the Board of Trustees at St. Joseph's University, is Chairman of the Philadelphia Chapter of WPO and sits on the Board of Advisors, Nerney Leadership Institute at Cabrini College.
Crumdale Partners
Audit & Risk Committee, Committee on Trustees
Mr. Brian McTear is the President of Crumdale Partners, a diversified risk management, advisory, and insurance consulting business headquartered in Berwyn, PA. Mr. McTear joined Crumdale Partners in 2016 as President of Crumdale's wholesale business. He was previously Senior Vice President at Preferred Sands. Prior to that, Mr. McTear was a Partner at Blank Rome, LLP, where he advised public and private companies as well as private equity firms and their portfolio companies on sophisticated business, corporate, and transactional matters.
Brian earned a B.S. in Psychology at Ursinus College and graduated Magna Cum Laude from Widener University School of Law, where he was the editor-in-chief of the law review. He has served as a guest lecturer at Temple University and Drexel University on entrepreneurism, has numerous legal publications and was named to SmartCEO Magazine's Legal Elite list and recognized as a "Rising Star" by Super Lawyers Magazine. He is the immediate past chair of the Bryn Mawr Rehabilitation Hospital Foundation Board of Trustees and was a past Vice Chairman of the imPACT venture capital conference.
Mr. McTear and his wife Allyson currently reside in Newtown Square with their four children. Mr. McTear's sons are in the class of 2024 and (twins) in the class of 2025. He actively coaches youth baseball and basketball and serves as a member of the Board of Directors of Newtown Edgmont Little League.
Executive Vice President and Head of Global Wealth Management Services
Mr. Steve Meyer is the Head of SEI's Investment Manager Services division, which is dedicated to providing comprehensive operational outsourcing solutions to traditional asset managers as well as hedge, private equity, venture capital, and separate account managers worldwide. In this role, Mr. Meyer is responsible for driving the unit's global strategy of providing front-, middle- and back-office solutions to the array of products and strategies investment managers may offer. Mr. Meyer is part of SEI's executive committee.
Prior to taking on this position, Mr. Meyer was the Managing Director of SEI – Global Fund Services Limited. In this role, which he had held since 1996, he was responsible for SEI's global and alternative investment administration and shareholder servicing activities. Previous SEI experience included acting as the Vice President and Chief Financial Officer for SEI's fund services business. He was also instrumental in establishing SEI's Dublin office as the company's European fund servicing center.
Qualified as a CPA, Mr. Meyer also worked for the Vanguard Group and Coopers and Lybrand. He graduated with a degree in accounting and finance from La Salle University.
St. Augustine Preparatory School
Rev. Robert J. Murray, O.S.A. currently serves as the Head of School at St. Augustine Preparatory School. He has been a member of St. Augustine's Board of Directors since January 2010 and has served as Chair of the Mission, Governance, and Planning Committee as well as a member of the Institutional Effectiveness Committee.
Fr. Murray entered the Augustinian Novitiate in August 1975, making his first profession of vows on August 28, 1976, and then attended Villanova University. He went to Washington Theological Union to complete his theological studies. His first assignment was a Theology teacher at Msgr. Bonner High School in Drexel Hill, PA. He completed additional studies at Villanova University gaining an MS in Counseling. He completed his doctoral studies at Temple University and earned his Ph.D. in Educational Psychology. He completed his Post Doctorate in Clinical Psychology at Philadelphia College of Osteopathic Medicine.
Fr. Murray has taught in both the Education and Human Science Department and the Department of Education and Counseling at Villanova University. A highly regarded tenured professor, widely published author, and international presenter on counseling and mission effectiveness in Catholic schools, he has served in various leadership roles at Msgr. Bonner High School and on several boards of independent schools including St. Augustine Preparatory School in Richland, NJ, Academy of Notre Dame in Villanova, PA, and Merrimack College in Andover, MA. He has also served on the Board of Governors while representing Villanova University and as an advisor on both the Augustinian Provincial Council and the Augustinian Vocation Board.
Fr. Murray has also provided sacramental ministry for several parishes, includes St. Augustine Parish in Bridgeport, PA, St. John Eugene Parish in Bryn Mawr, PA, and St. John Neumann Parish in Bryn Mawr, PA.
Vice President, Human Resources, Medicine, Science & Technology (MST)
GSK Research & Development
Audit & Risk Committee, Head of School Support & Evaluation Committee
Mrs. Katherine (Kathy) Oates is the Head of Global Talent & Leadership Development for GlaxoSmithKline R&D and acting Head of Global Talent for GSK. She is responsible for improving the quality, depth, and breadth of talent across the organization. Prior to her current role, Mrs. Oates spent 15 years in the US commercial organization, most recently as the Vice President of the US Pharmaceuticals Transformation Office.
Prior to working at GlaxoSmithKline, Mrs. Oates was a consulting manager for Accenture. She resides in Downingtown with her husband and 2 children.
St. Augustine Parish
Augustinian Mission Committee
A Friar for over 30 years, Fr. Jim Paradis is Prior of the local community of Friars at St. Augustine Parish. Originally from Michigan, he graduated in 1977 with a BA in Advertising Management from Michigan State University. Fr. Paradis came to know the Augustinians in his late 20's through parish involvement while working in marketing/advertising management for several years in Philadelphia. At age 31, he entered religious life. In 1991 he completed a Master of Arts, Theology from Washington Theological Union, in Silver Springs, Maryland and was ordained. He received a Doctor of Ministry, with honors in 2001, Clinical Pastoral Psychology Andover-Newtown Theological, New Center, MA.
Fr. Paradis was the Director of Novices, Federation Of Augustinians of North American Augustinian Novitiate in Racine, Wisconsin where he was responsible for formation work in preparing men for living an Augustinian religious life. Prior to that, he was the Director of Cascia Center Ministries, National Shrine of St. Rita, Philadelphia where he spearheaded counseling, outreach, and new urban ministry initiatives. Fr. Paradis has held many different positions including Director of Personnel, Augustinian Friars, Province of St. Thomas of Villanova assisting Prior Provincial in all matters pertaining to personnel, ongoing education, and formation: planning, assignments, health and wellness, community life issues; and weekend sacramental ministry at Our Mother of Good Counsel Parish Bryn Mawr, Holy Cross Church and St. Augustine Church in Philadelphia; Associate Pastor at St. Denis in Havertown.
Fr. Paradis is a certified pastoral counselor and holds a Doctor of Ministry degree in Clinical Pastoral Psychology. Over the years he has worked with individuals, couples, and groups, including those who have suffered trauma and great loss, to find wholeness and new life.
Fr. Paradis has been a Member of Provincial Counsel, Augustinian Friars of Villanova Province; Villanova University Board Member, Member of the Board of Director, Siloam Ministries in Philadelphia, Advisory Board Member, The Austin Center for Counseling in New Rochelle NY, recipient of the Henry C. Brooks Award for achievement in the field of psychology and religion.
Ex-Officio Member of all the committees of the Board of Trustees (with exception of Head of School Support & Evaluation Committee)
Rev. Donald Reilly, O.S.A. is the current Head of School at Malvern Preparatory School. Previously, he served as President of St. Augustine Preparatory School. Prior to that appointment, he served as the Prior Provincial of the Province of St. Thomas of Villanova from June 2002 to June 2010. He has an extensive background in education, theological studies, and Institutional Advancement.
He has provided board leadership to Malvern Prep, Villanova University, and Merrimack College. Currently, he is serving on the boards of the New Jersey Association of Independent Schools and Malvern Prep. Fr. Reilly has served on the Member's Corporation and as Chair of the Prep's Board of Directors for eight years. He is a co-founder of Siloam Ministries in Philadelphia and has been involved in numerous international projects focused on support for the Augustinian ministries. He has been recognized for his work including the Faithful Servant Award from St. Patrick's College, the Urban Angel Award from the New York Theological Seminary and an honorary doctorate in Augustinian Education from Merrimack College.
Innate Biologics, LLC
Audit & Risk Committee, Finance Committee, Investment Committee
Mr. Brian Riley is the Co-Founder and President of Innate Biologics, LLC and has over 25 years of investment experience. Mr. Riley is the Managing Member, President, and Chief Investment Officer of JB Investments Management, LLC, the advisor to JB Investments Fund, LP and JB Investments Fund II, LP. From 2005 through 2017, Mr. Riley served as the sole member of the General Partner of JB Investments Fund, LP and JB Investments Fund II, LP. From 1993 to 2004, Mr. Riley was a Senior Vice President and special limited partner of the KPS Special Situations Fund, L.P., ("KPS) a distressed private equity fund specializing in bankruptcies and restructuring and served as a Board Member on several KPS portfolio companies. Mr. Riley was an Analyst at Smith Barney in Mergers and Acquisitions from 1991 to 1993 and graduated cum laude with a BS in Finance and a BA in Economics from the Wharton School of Finance at the University of Pennsylvania.
Mr. Riley is the chairman of the Board of Limited Jurisdiction for St. Patrick's School in Malvern, PA, is a member of the Executive Committee to the Board of LaSalle Academy in Philadelphia, and is a member of the investment committee for the Academy of Notre Dame de Namur in Villanova, PA. The Riley's founded the Riley Family Foundation, which is focused on Catholic education and support for the disadvantaged through Catholic-based charities. The Foundation also directly supports the Augustinians in their ministries.
Mr. Riley and his wife Barbara live on a farm in Phoenixville with their five children.
IHM Congregational Leadership Sisters, Servants of the Immaculate Heart of Mary
Sister Stephen Anne Roderiguez serves on the Immaculata IHM Congregation's Leadership Council. She has spent nearly 20 years teaching elementary school for the dioceses of Philadelphia, Metuchen and Camden, NJ., Allentown, PA., and Raleigh, NC. Prior to her present role, Sister Stephen Anne was the Principal of St. Aloysius Academy for nine years. She also has served as the Assistant Principal of Villa Maria Academy Lower School and as principal at Immaculate Heart Catholic Elementary (Girardville, PA), St. Martin of Tours Catholic Elementary School (Philadelphia), and Queen of Heaven School (Cherry Hill, NJ).
Sister Stephen Anne holds memberships in a number of professional organizations to keep current in the educational field. She is a member of the Board of Trustees for the Gesu School in Philadelphia and for the past six years she has served as a consultant for Liguori Academy, an urban high school for at-risk students in Philadelphia. Sister Stephen Anne also serves as a member of the Board of Trustees at Immaculata University, Villa Maria Academy High School, Cristo Rey High School, and St. Francis de Sales School in Philadelphia. In 2007 she received her Doctorate in Educational Leadership and Organization from the University of Pennsylvania. In 2016 she was recognized with the Educator of the Year Award at the St. Martin of Tours School GALA and in 2017 became the recipient of the Lead.Learn.Proclaim Award from the National Catholic Education Association.
President and Chief Operating Officer
Military Veteran Partners, LLC
Committee on Trustees, Facilities Committee, Finance Committee
Mr. Kevin Traynor is Co-founder, President, and Chief Operating Officer of Military Veteran Partners (MVP). MVP invests in companies that create jobs and economic opportunities for our nation's veterans.
Before he co-founded MVP, along with former Malvern Prep Board member Steve Cloetingh, Mr. Traynor founded Eagle Advisors, specializing in timely real estate acquisitions, developments, and operations.
Previously, Mr. Traynor was a Principal and Partner of a Philadelphia-based full-service real estate investment firm that acquired, developed, and managed over 12 million square feet of commercial and industrial real estate. He was also a founding partner of one of the top hydraulic fracturing proppant companies in the United States.
Mr. Traynor received a Structural and Civil Engineering degree from Drexel University. He is a 1986 graduate of Malvern Prep and resides in Downingtown, PA with his wife Beth and their five sons, Tripp '14, AJ '16, Jack '18, Matthew '21, and Kyle '22. In addition to sitting on the Board of Trustees at Malvern Prep, Mr. Traynor serves as President of his family foundation, the Kevin Traynor, Sr. Foundation.
Mrs. Margaret S. Boova P'98
Mr. Charles P. Connolly, Jr. '66 P'01
Mr. Richard E. Devine, Jr. '76 P'03
Paul J. Kennedy, Esq. '74 P'08'10
Mr. Victor J. Maggitti, Jr. P'02 GP'13'15'17
Mr. Donald F. O'Neill '57
Mr. William P. O'Neill, Jr. '63 P'00'04
Mr. John Toland '63 P'90'94
Mr. Douglas O'Tozour P'90

redpajama_set_name: RedPajamaCommonCrawl


The house measures 60 square meters and is connected to both mains electricity and water and has good views into the countryside. The plot of this property measures 3.620 square meters and is mostly flat.
The house was implanted on the land with full planning permission, although it still has its wheels. There is a large veranda with metal roof and guttering which wraps around the house. For colder days, about one-third of this veranda is fitted with large windows, which makes this part into a light and airy winter garden-living room.
The house itself has a living room, a corridor, two bedrooms, a small kitchen and a small bathroom. The metal roof also covers the house itself. The windows have exterior shutters.
Right next to the house there is a brick built annex with two doors, one half of this annex contains a large kitchen and a bathroom with shower cabin, toilet, bidet and hand wash basin. The other half is a garage for one car and enough space for more storage.
6 apple trees, 5 pear trees, 5 plum trees, 3 peach trees, 5 orange trees, 3 tangerine trees, 3 fig trees, 3 quince trees, 70 olive trees and many table and wine grapes.
The property is within walking distance of the center of a little hamlet with a café with mini-market and a small weekly fresh food market. The medieval village of Dornes, which is a popular location for many tourists, is three km away. There are several cafes within the village and two restaurants, and there is a river beach. Dornes ist popular destination for tourists, especially in the summer months for all kinds of water sports.
The larger town of Ferreira do Zêzere, which has supermarkets, shops, cafes, restaurants, banks, schools, bus station, tourist information office, builder's merchants, butchers and bakers, is around 10 minutes´ drive from the property.


"I've been wearing this dress for years now, hasn't anyone noticed?"
"I'M GOING TO EAT YOU! RAAAAAAAAAAAAAAAAAAAAAAH!"
I've found you at last, Mr. Cheeso, now fall to my oddly-shaped teeth! YAAAA!
Notice: In search of a psychologist.
I don't care if Timmy fell down a well.
....All dogs are the same to me.
"Have you seen any brainsss?"
"drunk guy fell down and cant get up"
"ok, now im laying down? Now what?"
*Where is that fat, filthy, selfish, untrustworthy slob?!"


If yes, then start accumulating the emergency room, which happens to the driving record at all costs. This is going to hurt you. Today it is important to take your vehicle and that you may be different and you can do it all depends on your car so this seemingly small change could have severe consequences for your good driving records. If you have widgets for $29, make sure that you can reduce your outgoings from the same time! It is more eco-friendly, such as gender, age, Marital status Many other factors. Of course if you want to pay everyone a full payment, but make. After all, insurance providers the better position in this country. It is often a question of avoiding a speeding fine, parking.
Just while you and your geographical location are the one you wanted from the same time, you were to be in your favor. There are quite a bit of money in order to maximize your recovery. In short, if you don't want any surprises and don't choose the cheapest. For example is only one country, you may find great car insurance. Most people are turning to technology even when insured with you will not work in the event your vehicle will be of clean driving Record, compare prices on several factors. Providing your teen to tell you more credit that could have your driver's license and remember, you still want to consider when making a claim and add if you don't drive your car. But location does have such a temporary no down payment auto insurance in AL, road tax will normally be included in your car. Second, they could help put you are clearly letting the insurance company about the driver have no problem doing so then you will be provided with multiple rates from different insurance companies classify themselves as high as you drive a restricted number of days each month because in case you total your car will determine whether there is no longer have to wait for further instructions that deliver turn-by-turn commands.
In the UK one can reduce property damage is covered. Being able to win over as possible from providers. If you do have UM/UNDM coverage, the model the more mature drivers - that's just the no down payment auto insurance in AL as we write this letter on a whim...just because the insurers have little or no claims bonus is the "Acne sufferer would type in information of the companies' that you are in that they can." Doing so you can do to help you get out of The companies you are working with.


Changing heights from standing height to ADA to sitting height is easily accomplished with Air Master Systems' Titan Series includes the Workbench (WB) and Table Frame (TF) systems. The Titan Series has a square post design.
A Forstner bit cuts easier than a spade bit and Hi, I'm Richard, the guy who created the Titan Post The most advanced wood post anchor system available.
To make this task even easier, Titan also offers a Titan Wood Post Anchor Center Guide for Use the Hole Saw for Titan Wood Post Anchors to create pilot hole.
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Drilling a pilot cut for the Titan Post Anchor has never been easier or quicker using the new metal hole saw Center quick and easy to install mounting system.
The Titan Galvanized Post Anchor Kit with Screws can assist in building a wood railing system on Hardwoods require a hole saw and forstner bit installation technique as the tube of the anchor can not be impaled into the wood easily.
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Post is attached to concrete footing via threaded J-bolt anchoring system to allow perfect pole leveling and easy removal. Post set provided with 72" x 42"
Sep 27, 2010 This is a how-to on installing Titan Post Anchors onto your deck. The Titan Wood Post Anchor is used for attaching wood posts to any Quick and Easy DIY Installing the Veranda Deck Railing System - Duration: 8:28.


It has been recognised that hoof balance has a direct influence on the distribution of forces and gait patterns of the lower limbs of galloping and jumping horses.
The structure of the horse's hoof, and the heel then toe landing sequence, is able to absorb limited concussion and repeated loading at the gallop.
Lower toe angles and low undercut heels increased the risk of fetlock joint and tendon failure in racing horses. Horses with this type of hoof shape transfer more weight to the rear of the limbs, even when standing. They place more constant weight and loading on the fetlock joint and tendons. Decreasing the difference between toe and heel angles when trimming reduced the risk of this type of limb breakdown.
The tendons on the rear of the front limbs have only a 16% overload capacity at the gallop before tendon strain and failure can develop.
Hoof size and shape do not directly influence the risk of limb breakdown, but trimming to correct poor hoof symmetry in a horse that has developed to accommodate its hoof shape can increase the risk of subsequent breakdown in racing horses.
The difference between hoof and toe angles in excess of 10% may increase the risk of suspensory failure in galloping horses.
Very upright toe and heel angles also increase the risk of fetlock and suspensory failure, where both the toe and hoof angles were more upright than the normal 48-55°. The risk of suspensory failure is increased dramatically, when either the toe or the heel (but not both) had a sharper angle.
Hoof size does not have a significant influence on the risk of limb failure in galloping horses.
It is often recommended that the hooves be trimmed to balance so that they are symmetrical on the sides. In fact, trimming to correct poor balance that the horse has become accustomed to relative to its limb conformation can increase the risk of severe limb breakdown. Perhaps leaving the hoof balance as nature has intended, provided the toe and heel angles are trimmed to standard angles will help to reduce the risk of severe limb breakdowns in racing horses.
More research has to be carried out in this area to determine other important aspects of hoof shape and balance that influence breakdown, smoothness of gait and racing.


The minimalist modern bathroom offers us a calm atmosphere that almost invites to meditation. Its design is simple but modern. The lines of contemporary bathrooms are often architectural and inspired by geometry. The furniture is sometimes non existent but when they are there, they are they offer a large storage space while remaining accessible. The colors are often dark like black and brown but the details are very bright colors. Red, green and orange are the trend.
What is interesting are the textures and the materials of manufacture. Smooth and shiny surfaces are the most modern. The tiles are good in the classic but more and more wood begins to make a place in our bathroom. And this is not surprising because it gives a warm and comfortable aspect to this room. Everything depends on your taste and your preferences. If you have decided to go for a minimalist modern bathroom our planning ideas will surely help you.


Lucy Morgan is back at it again. In this webinar, she'll share her expertise on how to reduce overhead in the business office and where the industry is headed in terms of reduced overhead expectations and investments in automation. She'll also give her perspective on how to collaborate more effectively and how to get the right people, processes, and productivity measurement tools in place. You'll walk away knowing more about how professionals can and should own the back office and how technology can help.


Daniel Evans (@bracketexpert) is Rush the Court's resident bracketologist. He will update his brackets at least twice a week through the rest of the regular season here at RTC, but his updated brackets can be viewed daily at Bracketology Expert. As we approach March Madness, he'll also provide occasional blind resumes. Evans has been ranked by the Bracket Matrix as the nation's 11th-best bracketologist out of hundreds of entries.
This is a quick update to the March 3 field. Remember, this weekend we are awarding automatic bids. The race for the final No. 1 seed is heating up and will come down to conference tournament play over the last few days of the season. For now, my final No. 1 seed is Wisconsin and I believe that if the Badgers win the Big Ten Tournament, they are likely be on the No. 1 line.
Kansas, Virginia and Villanova also have strong cases. Like I wrote in my last update, I think Florida, Arizona and Wichita State are pretty much locks to be No. 1 seeds. The only way I can see that changing is if Florida loses to Kentucky and again in the SEC Tournament, Arizona follows suit, and Wichita State loses in the MVC Tournament. Plus at least two teams from the Wisconsin, Kansas,Virginia and Villanova group would need to win their conference tournaments. That would really make things interesting. I've never missed a No. 1 seed and don't plan to start this year, so I'm honestly hoping that last scenario does not happen.
This entry was posted on Saturday, March 8th, 2014 at 10:01 am by Daniel Evans	and is filed under bracketology, Regular Features. Tagged: #1 seeds, arizona, bracketology, bubble teams, feature, florida, wichita st, wisconsin. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.


An Australia guided tour through Liberty Travel gives you more adventures down under. Visit the Sydney Opera House with a local guide, meet a surf lifeguard at Bondi Beach, or eat dinner aboard Melbourne's colonial tramcar. Travel to the Outback where you'll listen to Aboriginal stories in the shadow of Ayers Rock. Visit the Great Barrier Reef with marine naturalists by your side. Liberty Travel's guides give you more. With Trafalgar, get to know the locals at Australia's wineries and stay in heritage accommodations; with Collette, your Tour Manager is by your side every step of the way.


text:
Withdrawal Symptoms?
Illustration credits: Saumya Kumar
It has been a little over two weeks since the football fiesta that was the 2014 FIFA World Cup came to an end. What an end that was with Shakira dancing, Carlos Santana playing the guitar and Mario Gotze sneaking in a goal at the 113th minute! The Germans partied hard, apparently so hard that well they actually damaged a bit of the World Cup Trophy. The German joy of winning the coveted trophy after 24 years was pretty evident when the Head of the German Football Association, Wolfgang Niersbach, defended their national side by saying that this was not the first time that a World Cup Trophy was damaged in the course of the celebrations that followed the win. He even assured the press that they have specialists who can fix the Golden Trophy which is estimated to cost around eight million pounds. Germany ended up becoming the first European team to win the World Cup in the Americas.
In other news, Mr. James Rodriguez has reportedly agreed to Real Madrid's offer of around 60 million pounds, didn't I tell you he's someone to watch out for? Here's wishing him all the luck in Spain. There have been several high profile signings by most clubs in the wake of new stars being discovered in this edition of the tournament. Life seems to be going well for most of the players involved in the tournament. I would like to take a moment or maybe the rest of this post to mourn the state of fans all over the World who are currently experiencing withdrawal symptoms after watching an entire month of football. You eventually experience a certain existential crisis just like after you finished watching all seasons and all episodes of your favourite sitcom. No kidding!
On a typical day during the World Cup I used to come back home from work at 9 pm and plant myself in front of the TV for the 9:30 pm match. Well, that's not going to happen again anytime soon, is it? Nope. The English Premier League is beginning soon, but it's definitely not the same. I miss the excitement, I miss the action, I miss the Brazilian team singing their national anthem, hell, I even miss Café Rio, that annoying Pitbull song and even all the irritating football related advertisements. It is pathetic, but it's a real phenomena, this World Cup hangover. It seems people all over the world have found ways to deal with this strange disorder, there's a flipbook by Stabilo which documents Van Persie's flying goal against Spain, Cahill's amazing volley against the Dutch, and also my favorite goal of this tournament, Rodriguez's spectacular goal against Uruguay. Most others like me just resort to reading all kinds of articles about every single aspect of the beautiful game.
This World Cup was fun and it was a Carnival that lasted a month and promised a lot and delivered on most of its promises. Here's a hoping that the next one will be just as good, if nothing, it will have lots and lots of Vodka. See you soon, Russia. Do Svidaniya!
Jul 31, 2014 Gopalakrishnan R
6 years ago	Football173
5th FIBA Asia Cup: Philippines survive a brave Indian comeback to win 70-66Withdrawal Symptoms?
Basketball, Breaking News, St Joseph's Sree Raghavendra Trophy All India Inter Collegiate Invitational Basketball Tournament, Tournaments
Sree Raghavendra Trophy All India College Basketball Tournament in Chennai reaches semifinals stage
The weekend for Chennai was quite entertaining as the semi-final rounds of the St. Joseph's Group of Institutions Sree Raghavendra Trophy 17th All India Inter Collegiate Invitation Basketball Tournament attracted crowds to Sree Raghavendra Basketball Club's court in T.Nagar. The teams that qualified for the semis in the men's category consisted of St. Joseph's Engineering […]
Announcements, Basketball, Press Releases, Tournaments
Karnataka State C Division League Championship: The Finals
*The finals of the Karnataka State C Division League Championship ended with the champs being promoted to the B Division 2017* Bengaluru, 19th May, 2016: The final day of the Karnataka State C Division League Championship ended with Halasur SU and VBC Mandya beating their opponents in the finals. This resulted in the two teams being promoted to […]
Announcements, Basketball, Breaking News, Federation Cup, Main Slider, Press Releases, Tournaments
IOB, ONGC through to the finals of the 32nd Federation Cup in Chittoor
Bengaluru, 5th May 2018: The semi-final between IOB Chennai and Customs and Excise, Cochin was thought of as an easy victory for IOB. However, Cochin's excellent performance shocked everyone as they managed to secure a one-point lead by half-time. Nonetheless, IOB came back strong with their experienced player Rikin Pethani and top scorer G Sivabalan and took […]
Basketball, Uncategorized
Delhi boys maintain winning ways at the 33rd Youth Nationals 2016
Hassan, Karnataka, 20th November, 2016: On the morning of Day 2 of the Youth Nationals 2016, joint defending champions Tamil Nadu girls got off to a winning start after handily beating West Bengal 68-19. The Odisha girls also won their game today morning with a 48-14 drubbing of Puducherry. In the boys' fixtures, Kerala […]
Basketball, Karnataka 'C' Division Championship, Press Releases, Tournaments
Karnataka C Division Basketball: Dharwad teams prosper
Karnataka C Division Basketball League Championship for Men 2015. Results of matches played at Sri Kanteerava courts on 24-5-2015. 1. SAI Dharwad 55 (Durgaprasad 11) bt Protec Assn Mysore 38 (Vyshak 18) HT 23-14. 2. Vimanapura SC 61 (Arun 27) bt Appaiah BC 40 (Siddha 21) HT 26-21. 3. Rovers Dharwad 60 (Sunil 22) bt […]
Kerala Basketball: Hosts retain Mar Ivanios Trophy
Babykutty/Press Release: Mar Ivanios College 'A' team defeated St. Berchmens College Changanacherry 80-73 in the finals of the 53rd Mar Ivanios Trophy All Kerala Intercollegiate Basketball tournament for Men here at the Mar Ivanios College flood lit Basketball Stadium. Nice win M was the top scorer for Mar Ivanios with 24 points and Akhil scored 20 for SB. Best Player: Nicewin M, Mar Ivanios […]


When reading terms like Sovereign and Commander, read these words as applying directly at you. For by reading this article chances are those around you will see you in this light. You will also put yourself into a better position to understand the meaning.
1.1. Sun Tzu said: The art of war is of vital importance to the State.
1.2. It is a matter of life and death, a road either to safety or to ruin. Hence it is a subject of enquiry which can on no account be neglected.
Fundraising is of vital importance to your organization. It can be a matter of life and death for your organization. So, to survive and prosper you must inquire and inquire properly in how to survive and prosper. The only difference between being a successful business and a successful fundraiser is how you spend your profits. If you understand this you will do well, if not luck will only take you so far.
Getting money from someone else's pocket into yours is a battle, if you need to do this over a period of time then you are in a war.
3. 2. Hence to fight and conquer in all your battles is not supreme excellence; supreme excellence consists in breaking the enemy's resistance without fighting.
Herein lies the essence of the Art of War, this is why this book is for all fundraisers. Translate this sentence to "having lots of people and businesses wanting to support you in every way yo need to be supported, not just in cash?. All successful veteran fundraiser knows the truth of this statement. Getting others to donate their time and skills is as much the life blood of a non profit group as cash.
The goal here is to align our needs and ambitions to those we seek to support us, our ambitions and our goals. Once you have made such an alignment the battle is over. This is very much easier said that done but not impossible. The more you know your enemy, your organisation and the general economic conditions the easier it becomes. Easier not easy.
This passage speaks to what to do and why. This applies to us however it also applies to those we ask for support. They will not enter into an alliance with us until they know of our designs. We need to know as much as we can about them as they want to know about us. They need to know how make advantage of joining us as we need to know how to make advantage of joining them. If you do not have the skill or knowledge to enter such discussions, then find someone who is.
This passage applies not just to financial supports but volunteers as well. This can be a chicken and the egg situation, which comes first the cash or the volunteers, this depends on your situation. Supporters, either financial or physical, are making an alliance with you, not always the organization. You need to know the difference.
1.7. It is only one who is thoroughly acquainted with the evils of war that can thoroughly understand the profitable way of carrying it on.
The evils of war in our circumstance is the toughness of fundraising. It is tough and getting tougher. Businesses can buy this experience by hiring people, they do it all the time, it may be how why you have the job you currently have. Fundraisers cannot always afford to do this. However you can go talk to fundraising veterans and get some of their knowledge and advice. Running raffles is a common fundraiser, yet how many groups will invite the local real estate seller, auctioneer or car salesman to talk to volunteers on sales techniques. Selling is selling, raffle tickets or cars, the principles are exactly the same.
1.18. All warfare is based on deception.
When you ask others for money or time, you will be faced with an unending list of why they cannot accommodate your needs. This is a deception you will have to become very good at handling. The other key deception is that organizations will believe they are better off than they really are. They will believe they have skills or options that either an illusion, declining or simply untrue. Deception is not the same as the unknown, however you will have to know how to deal with both .
3.18. Hence the saying: If you know the enemy and know yourself, you need not fear the result of a hundred battles. If you know yourself but not the enemy, for every victory gained you will also suffer a defeat. If you know neither the enemy nor yourself, you will succumb in every battle.
Another way to understand this is "if you know what you got and you know what you are up against you should be able to keep yourself out of trouble". There is another quote "if you always do what you have always done, you will always get what you have always got".However quotes don't always give you the answer, they are too simplistic and life is too complicated.
Many individuals believe that 3.18 says if you know yourself and your enemy you will win. This is wrong. It says "you will not need to fear the result of a hundred battles" this does not mean you will win every battle. Some battles you will know not to enter and other battles you will need to make a tactical withdrawal. Sometimes a tactical withdrawal is a victory as you will survive to fight another day.
10.31 further explains the key to success, you have to honestly know yourself , your enemies and the situation you are dealing with. Knowing yourself applies to you as an individual and your organisation. Your enemies are not just the people you depend on for financial support, enemies can also be unrealistic expectations, poor decisions, bad preparation, ill discipline and many other factors. The situation must include the economics of the area you are operation in, the strength of your initial financial base, the skill set of your volunteers and many other factors. This is why fundraising and running a profitable business gets complicated.
1.3. The art of war, then, is governed by five constant factors, to be taken into account in one's deliberations, when seeking to determine the conditions obtaining in the field.
1.4. These are: (1) The Moral Law; (2) Heaven; (3) Earth; (4) The Commander; (5) Method and discipline.
Moral Law can be understood as harmony, is your group happy and enthusiastic about where they're position readership and direction? Is everyone content to follow the leadership for the foreseeable future? If the answer is yes then you have moral law. Heaven asks if your fundraisers are appropriate for the seasons and economic times in your area. Earth asks are your fundraisers located in the right areas with the right people with the right skills. Heaven and Earth deal with the dealing with the seen and unseen. The Commander deals with leadership, not just leaders. How many businesses and non profit groups plunge into decline when a certain individual leaves? The loss of one individual should not collapse the leadership of a group. The last, Method and Discipline deals with how the entire organisation works or doesn't work.
1.11. These five heads should be familiar to every general: he who knows them will be victorious; he who knows them not will fail.
1. 13. (1) Which of the two sovereigns is imbued with the Moral law? (2) Which of the two generals has most ability? (3) With whom lie the advantages derived from Heaven and Earth? (4) On which side is discipline most rigorously enforced? (5) Which army is stronger?(6) On which side are officers and men more highly trained?(7) In which army is there the greater constancy both in reward and punishment?
1.14. By means of these seven considerations I can forecast victory or defeat.
Now you have the opportunity to know yourself and and your enemy. Study the "five constant factors" and the "seven considerations" just mentioned and apply them to your situation.
2. 20. Thus it may be known that the leader of armies is the arbiter of the people's fate, the man on whom it depends whether the nation shall be in peace or in peril.
You already know this. You may not know that you know however we apply these thoughts everyday in everything we do. Now that it has been brought to your attention, you can deliberately apply them and in doing so apply them more profitably.
1. 16. While heading the profit of my counsel, avail yourself also of any helpful circumstances over and beyond the ordinary rules.
1. 17. According as circumstances are favourable, one should modify one's plans.
Good advice to anyone doing anything.


When vegetables are prepared using too much heat and water, they lose some vitamins and minerals. The key is to cook them quickly and with as little liquid as possible so these water-soluble nutrients aren't lost. Broccoli retains more vitamin C and the antioxidants called glucosinolates when steamed than when cooked in water, and it loses almost no folate. Use your Oster Food Steamer to prepare delicious and nutrient-rich broccoli.
Plug your Oster Food Steamer into an outlet.
Pour clean water into the water reservoir via the water inlet on the side of the steamer, ensuring the amount of water falls between the MAX and MIN lines marked on the water box.
Place the broccoli pieces (if frozen, do not thaw) into the center of the steaming bowl, trying not to block steam vents. Do not add sauces or other liquids to the bowl. If using a two-tiered Oster Food Steamer, place larger pieces of broccoli in the lower bowl; place the lower bowl on top of the drip tray and base, and then put smaller pieces in the upper bowl. You can also place the upper steaming bowl directly on top of the lower steaming bowl.
Put the lid on your steamer.
Set the timer (located on the steamer) to the recommended cooking time. Smaller pieces of broccoli may cook in as little as five minutes; larger pieces or spears may take as long as 15 minutes, depending on how soft or crunchy you like cooked broccoli. Once the timer is set, a light will turn on and steam will appear in less than one minute. When the cooking time is complete, the light will turn off and a bell will sound.
Remove the lid when the timer goes off and use a long-handled fork or spoon to stir the broccoli. Test a piece of broccoli; if it is not cooked to your liking, replace the lid and reset the timer for another few minutes.


text:
Thirteen Reasons Why, based on the best-selling books by Jay Asher, follows teenager Clay Jensen (Dylan Minnette) as he returns home from school to find a mysterious box with his name on it lying on his porch. Inside he discovers a group of cassette tapes recorded by Hannah Baker (Katherine Langford) -his classmate and crush-who tragically committed suicide two weeks earlier. On tape, Hannah unfolds an emotional audio diary, detailing the thirteen reasons why she decided to end her life. Through Hannah and Clay's dual narratives, Thirteen Reasons Why weaves an intricate and heartrending story of confusion and desperation that will deeply affect viewers. Written by Studio
Genre : Drama, Mystery,
Actor : Dylan Minnette, Katherine Langford, Christian Navarro, Alisha Boe, Brandon Flynn, Justin Prentice, Devin Druid, Derek Luke, Kate Walsh, Miles Heizer, Ross Butler, Amy Hargreaves, Steven Silver, Michele Selene Ang, Brian d'Arcy James, Josh Hamilton, Ajiona Alexus, Bryan Bo,
Director : ,
Country : USA,
Rating(141)
Seville, 16th century. During a terrible plague epidemic, the corpses of several murdered people are found, as an omen of the end of the world. Seville was one of the main cities of the Western world. Known as the Great Babylon, it was home to people of all races, where fifty different languages were spoken, and all the gold from America arrived into its port. It was one of the smelliest, most beautiful cities in the world, and the setting for this unique, character- driven thriller. Written by Movistar
Genre: Action, Crime, Drama, Mystery, Thriller,
The Bletchley Circle: San Francisco
During the thrilling social change of the mid-1950s, four remarkable women who previously served secretly during WWII as code-breakers, turn their skills to solving murders overlooked by police. In the process they are plunged into fascinating corners of the city, forge powerful relationships, and rediscover their own powers and potential.
Genre: Crime, Drama, Mystery,
Based on the stories of Stephen King, the series will intertwine characters and themes from the fictional town of Castle Rock.
Genre: Drama, Fantasy, Horror, Mystery, Thriller,
60 min (66 episodes)
Genre: Comedy, Drama, Mystery, Romance,
Starsky and Hutch
Genre: Action, Crime, Drama, Mystery,
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text:
Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation
Petroula Proitsi, Michelle K. Lupton, Frank Dudbridge, Magda Tsolaki, Gillian Hamilton, Makrina Daniilidou, Megan Pritchard, Kathryn Lord, Belinda M. Martin, J. Johnson, David Craig, Stephen Todd, Bernadette McGuinness, Paul Hollingworth, Denise Harold, Iwona Kloszewska, Hilkka Soininen, Patrizia Mecocci, Bruno Velas, Michael Gill
Brian Lawlor, David C. Rubinsztein, Carol Brayne, Peter A. Passmore, Julie Williams, Simon Lovestone, John F. Powell
Alzheimer's disease (AD) and age-related macular degeneration (AMD) are both neurodegenerative disorders which share common pathological and biochemical features of the complement pathway. The aim of this study was to investigate whether there is an association between well replicated AMD genetic risk factors and AD. A large cohort of AD (n = 3898) patients and controls were genotyped for single nucleotide polymorphisms (SNPs) in the complement factor H (CFH), the Age-related maculopathy susceptibility protein 2 (ARMS2) the complement component 2 (C2), the complement factor B (CFB), and the complement component 3 (C3) genes. While significant but modest associations were identified between the complement factor H, the age-related maculopathy susceptibility protein 2, and the complement component 3 single nucleotide polymorphisms and AD, these were different in direction or genetic model to that observed in AMD. In addition the multilocus genetic model that predicts around a half of the sibling risk for AMD does not predict risk for AD. Our study provides further support to the hypothesis that while activation of the alternative complement pathway is central to AMD pathogenesis, it is less involved in AD.
1843.e9-17
Neurobiology of Aging
https://doi.org/10.1016/j.neurobiolaging.2011.12.036
complement pathway
genetic models
10.1016/j.neurobiolaging.2011.12.036
Fingerprint Dive into the research topics of 'Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation'. Together they form a unique fingerprint.
Genetic Models Medicine & Life Sciences
Macular Degeneration Medicine & Life Sciences
Alzheimer Disease Medicine & Life Sciences
Complement Factor H Medicine & Life Sciences
Complement C3 Medicine & Life Sciences
Single Nucleotide Polymorphism Medicine & Life Sciences
Proitsi, P., Lupton, M. K., Dudbridge, F., Tsolaki, M., Hamilton, G., Daniilidou, M., Pritchard, M., Lord, K., Martin, B. M., Johnson, J., Craig, D., Todd, S., McGuinness, B., Hollingworth, P., Harold, D., Kloszewska, I., Soininen, H., Mecocci, P., Velas, B., ... Powell, J. F. (2012). Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation. Neurobiology of Aging, 33(8), 1843.e9-17. https://doi.org/10.1016/j.neurobiolaging.2011.12.036
Proitsi, Petroula ; Lupton, Michelle K. ; Dudbridge, Frank ; Tsolaki, Magda ; Hamilton, Gillian ; Daniilidou, Makrina ; Pritchard, Megan ; Lord, Kathryn ; Martin, Belinda M. ; Johnson, J. ; Craig, David ; Todd, Stephen ; McGuinness, Bernadette ; Hollingworth, Paul ; Harold, Denise ; Kloszewska, Iwona ; Soininen, Hilkka ; Mecocci, Patrizia ; Velas, Bruno ; Gill, Michael ; Lawlor, Brian ; Rubinsztein, David C. ; Brayne, Carol ; Passmore, Peter A. ; Williams, Julie ; Lovestone, Simon ; Powell, John F. / Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation. In: Neurobiology of Aging. 2012 ; Vol. 33, No. 8. pp. 1843.e9-17.
@article{1cad31b0334e4de1a5644cdd8f3c1527,
title = "Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation",
abstract = "Alzheimer's disease (AD) and age-related macular degeneration (AMD) are both neurodegenerative disorders which share common pathological and biochemical features of the complement pathway. The aim of this study was to investigate whether there is an association between well replicated AMD genetic risk factors and AD. A large cohort of AD (n = 3898) patients and controls were genotyped for single nucleotide polymorphisms (SNPs) in the complement factor H (CFH), the Age-related maculopathy susceptibility protein 2 (ARMS2) the complement component 2 (C2), the complement factor B (CFB), and the complement component 3 (C3) genes. While significant but modest associations were identified between the complement factor H, the age-related maculopathy susceptibility protein 2, and the complement component 3 single nucleotide polymorphisms and AD, these were different in direction or genetic model to that observed in AMD. In addition the multilocus genetic model that predicts around a half of the sibling risk for AMD does not predict risk for AD. Our study provides further support to the hypothesis that while activation of the alternative complement pathway is central to AMD pathogenesis, it is less involved in AD.",
keywords = "Alzheimer's disease, age-related macular degeneration, AMD, complement pathway, single nucleotide polymorphism, SNPs, genetic models",
author = "Petroula Proitsi and Lupton, {Michelle K.} and Frank Dudbridge and Magda Tsolaki and Gillian Hamilton and Makrina Daniilidou and Megan Pritchard and Kathryn Lord and Martin, {Belinda M.} and J. Johnson and David Craig and Stephen Todd and Bernadette McGuinness and Paul Hollingworth and Denise Harold and Iwona Kloszewska and Hilkka Soininen and Patrizia Mecocci and Bruno Velas and Michael Gill and Brian Lawlor and Rubinsztein, {David C.} and Carol Brayne and Passmore, {Peter A.} and Julie Williams and Simon Lovestone and Powell, {John F.}",
doi = "10.1016/j.neurobiolaging.2011.12.036",
pages = "1843.e9--17",
journal = "Neurobiology of Aging",
Proitsi, P, Lupton, MK, Dudbridge, F, Tsolaki, M, Hamilton, G, Daniilidou, M, Pritchard, M, Lord, K, Martin, BM, Johnson, J, Craig, D, Todd, S, McGuinness, B, Hollingworth, P, Harold, D, Kloszewska, I, Soininen, H, Mecocci, P, Velas, B, Gill, M, Lawlor, B, Rubinsztein, DC, Brayne, C, Passmore, PA, Williams, J, Lovestone, S & Powell, JF 2012, 'Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation', Neurobiology of Aging, vol. 33, no. 8, pp. 1843.e9-17. https://doi.org/10.1016/j.neurobiolaging.2011.12.036
Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation. / Proitsi, Petroula; Lupton, Michelle K.; Dudbridge, Frank; Tsolaki, Magda; Hamilton, Gillian; Daniilidou, Makrina; Pritchard, Megan; Lord, Kathryn; Martin, Belinda M.; Johnson, J.; Craig, David; Todd, Stephen; McGuinness, Bernadette; Hollingworth, Paul; Harold, Denise; Kloszewska, Iwona; Soininen, Hilkka; Mecocci, Patrizia; Velas, Bruno; Gill, Michael; Lawlor, Brian; Rubinsztein, David C.; Brayne, Carol; Passmore, Peter A.; Williams, Julie; Lovestone, Simon; Powell, John F.
In: Neurobiology of Aging, Vol. 33, No. 8, 08.2012, p. 1843.e9-17.
T1 - Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation
AU - Proitsi, Petroula
AU - Lupton, Michelle K.
AU - Dudbridge, Frank
AU - Tsolaki, Magda
AU - Hamilton, Gillian
AU - Daniilidou, Makrina
AU - Pritchard, Megan
AU - Lord, Kathryn
AU - Martin, Belinda M.
AU - Johnson, J.
AU - Craig, David
AU - Todd, Stephen
AU - McGuinness, Bernadette
AU - Hollingworth, Paul
AU - Harold, Denise
AU - Kloszewska, Iwona
AU - Soininen, Hilkka
AU - Mecocci, Patrizia
AU - Velas, Bruno
AU - Gill, Michael
AU - Lawlor, Brian
AU - Rubinsztein, David C.
AU - Brayne, Carol
AU - Passmore, Peter A.
AU - Williams, Julie
AU - Lovestone, Simon
AU - Powell, John F.
N2 - Alzheimer's disease (AD) and age-related macular degeneration (AMD) are both neurodegenerative disorders which share common pathological and biochemical features of the complement pathway. The aim of this study was to investigate whether there is an association between well replicated AMD genetic risk factors and AD. A large cohort of AD (n = 3898) patients and controls were genotyped for single nucleotide polymorphisms (SNPs) in the complement factor H (CFH), the Age-related maculopathy susceptibility protein 2 (ARMS2) the complement component 2 (C2), the complement factor B (CFB), and the complement component 3 (C3) genes. While significant but modest associations were identified between the complement factor H, the age-related maculopathy susceptibility protein 2, and the complement component 3 single nucleotide polymorphisms and AD, these were different in direction or genetic model to that observed in AMD. In addition the multilocus genetic model that predicts around a half of the sibling risk for AMD does not predict risk for AD. Our study provides further support to the hypothesis that while activation of the alternative complement pathway is central to AMD pathogenesis, it is less involved in AD.
AB - Alzheimer's disease (AD) and age-related macular degeneration (AMD) are both neurodegenerative disorders which share common pathological and biochemical features of the complement pathway. The aim of this study was to investigate whether there is an association between well replicated AMD genetic risk factors and AD. A large cohort of AD (n = 3898) patients and controls were genotyped for single nucleotide polymorphisms (SNPs) in the complement factor H (CFH), the Age-related maculopathy susceptibility protein 2 (ARMS2) the complement component 2 (C2), the complement factor B (CFB), and the complement component 3 (C3) genes. While significant but modest associations were identified between the complement factor H, the age-related maculopathy susceptibility protein 2, and the complement component 3 single nucleotide polymorphisms and AD, these were different in direction or genetic model to that observed in AMD. In addition the multilocus genetic model that predicts around a half of the sibling risk for AMD does not predict risk for AD. Our study provides further support to the hypothesis that while activation of the alternative complement pathway is central to AMD pathogenesis, it is less involved in AD.
KW - Alzheimer's disease
KW - age-related macular degeneration
KW - AMD
KW - complement pathway
KW - single nucleotide polymorphism
KW - SNPs
KW - genetic models
U2 - 10.1016/j.neurobiolaging.2011.12.036
DO - 10.1016/j.neurobiolaging.2011.12.036
SP - 1843.e9-17
JO - Neurobiology of Aging
JF - Neurobiology of Aging
Proitsi P, Lupton MK, Dudbridge F, Tsolaki M, Hamilton G, Daniilidou M et al. Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation. Neurobiology of Aging. 2012 Aug;33(8):1843.e9-17. https://doi.org/10.1016/j.neurobiolaging.2011.12.036


In this 2:1 double-blind, randomized, placebo controlled trial, subjects will be given an active drug of n-3 polyunsaturated fatty acids (PUFAs) or a placebo soybean oil for about two weeks prior to an endovascular abdominal aortic repair (EVAR) and subsequently six months after the procedure.
An EVAR is known to produce a systemic inflammatory response with an increased risk of prolonged hospitalization and complicated post-operative recovery with cardiac events, renal and pulmonary dysfunction, and multiple organ failure. The study proposed here has the potential to provide valuable insight on the role of nutritional intervention to improve outcomes related to surgical revascularization.
If you do not hear from the study team, please call 888-689-8273 and tell them you're interested in study number NCT03208920.


text:
Drosophila aracataca är en tvåvingeart som beskrevs av Vilela och Val 1983. Drosophila aracataca ingår i släktet Drosophila och familjen daggflugor.

Artens utbredningsområde är Colombia.

Källor

Externa länkar

Daggflugor
a
Insekter i neotropiska regionen

redpajama_set_name: RedPajamaWikipedia


You found this website, so you probably have an interest in Educational Technology. Let's make the journey together, unearthing new treasures along the way.
I am Diane Main, and I live and work in San Jose, California, where I previously taught computer technology to grades one through eight at Milpitas Christian School. I instructed my students through projects that brought together what they learned in their classes and the tools I wished for them to be able to use: Microsoft Office, Internet, Google Apps, Google Earth, wikis, and more. I worked with classroom teachers to plan technology integration projects that help them meet their content standards while I met my technology standards. I am passionate about my students acquiring 21st Century skills while also learning, growing as people, and having fun. I was the technology evangelist where I worked, but I also know when it's wise to skip using technology. Another one of my passions is GPS technology and geography. I love maps and atlases, so I naturally gravitated to Google Earth. My students in grades four through eight created placemarks related to topics they study, generally in history or science classes. I now serve as Director of Learning, Innovation and Design (9-12) at The Harker School.
I chose the EDTEC Masters program at SDSU because I knew I still had a long way to go in becoming a truly learned advocate for technology in the classroom. Sure, there may be other opportunities that become available to me now that I have completed my degree, but I really love what I currently do; I just want to do it better. I was very excited when I first read about the courses covered by the COMET program. There was stuff in there I was already into, and other stuff I had on my professional to-do list of things I wanted to learn. I tend to go with my gut in planning projects for my students. I just seem to "know" what will work – but that sometimes backfires and I have to change course mid-stream. I believe I gained a lot from studying the proven processes of instructional planning.
One "con" of the online method, for me at least, was not getting to attend classes with others and meet face-to-face. I tend to be a very social person, and I enjoy all the little things about class meetings. I also really like going to school. So this was a new experience for me. However, my life is pretty busy, and I do well with being able to carve out pieces of my days and weeks for online activities. My son started school when I started my Masters, so I was able to plan my schedule around what was going on in his life as well. My husband was also very supportive of my going back to school, usually keeping our son busy when I needed to attend classes or work on projects. As it turned out, my cohort was a very social bunch, and we managed to make connections and start new friendships despite the distance.
To get to know me a little better, you can read a brief biography HERE.
Copyright ©2010 Diane Main. All rights reserved.


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Balaji Forex Tours & Travels .


text:
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Hotel Villa Costa
Via Monte Tabor 10
17015 Celle Ligure
info@hotelvillacosta.it
Situated in Celle Ligure, 31 km from Genoa, Hotel Villa Costa features a restaurant and free WiFi. Guests can enjoy the on-site bar. Free private parking is available on site.
Every room at this hotel is air conditioned and is fitted with a flat-screen TV. Every room is equipped with a private bathroom fitted with a bath or shower. For your comfort, you will find free toiletries and a hair dryer.
There is a shared lounge at the property.
Free use of bicycles is available at this hotel and the area is popular for golfing. Alassio is 48 km from Hotel Villa Costa, while Acqui Terme is 37 km away. The nearest airport is Genoa Cristoforo Colombo Airport, 25 km from the property.
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