We've set the days for next years Walleye Blast. April 19, 20 & 21. This is a fantastic time. Now nearly a full years notice should be enough to adjust schedules. If you like walleyes, fishing, fun times with good friends then this is the place and time to do it. I don't need an answer now. I just wanted to let everyone know this is going to be repeated next year.
UPDATE 4/25/15: I just got photo of the 8 fish caught today AMAZING! I'll post it later. I know soft plastic guru put us on the fish, the weather just was against us.
This will allow you to estimate your travel time and expense.
The cost: Is completely dependent on how many come. The more guys that participate the lower the cost per person. The cost covers your lodging and deck time on the water. Believe me the memories alone are priceless. When the time gets closer soft plastic guru and I will be able to nail it down. If your interested send me a PM.
Dates look good, I think I can make it.
The dates have been changed to Tuesday the 19th, Wednesday the 20th and Thursday the 21st of April 2016. These dates are confirmed with soft plastic guru and locked in. The plan once again is to meet at Oak Harbor, OH at 11:00 AM. Perhaps get a little line soaking in that afternoon. Then three exciting days of great LIMITING out fishing.
I'm asking anyone interested to send me a PM. I know it's a long ways off. But soft plastic guru is already booked up for next years spring spawning season. Now that should tell you this is pretty incredible stuff. Great fishing and super TH friends! What could be better? I know I'm going and so is Split toe and Gutshot. I hope sjk71 is able to make it. There's room for a few more.
FISH ON!!! FISH ON!!! FISH ON!!!
I go catching not fishing!! FISH ON!!!
I think I'll be there too!!!
Hunt hard and take kids fishing!!!
I wish I could make it, but late April is a time I cant be away from the farm.
During Summer Blast we recruited WV as another WB participant. Now we're gonna have some fun.
There's still room for up to six more members. The most fun you'll have on and off the water. Gotta have me some more knuckles!!!!!
I'm Looking Forward To It!!!!!
I talked to SPG last night. IMPORTANT ANNOUNCEMENT! The reservations deadline to go on this trip is September 15th. We have more room but will need to plan accordingly. SPG can accommodate 6 at one time on his boat. If we have more members going he'll either rotate guys going out or reserve another boat. I'll guarantee you'll have a great time. With Split toe and wvwhitetail around there will be side splitting laughter constantly.
To repeat: We are going to have to know by Sept. 15th how many more are coming along with the 6 already committed. This is an extremely busy time because of the walleye spawning season. Most trips are booked over a year in advance. Our's is no exception. Trying to be flexible to have more of our members come was our goal. We accomplished our goal. Now we just need to get all of the logistics worked out. If anyone wants to PM me and ask questions shoot it to me.
SORRY. This event is now booked and set. If anyone is still would like to sign up they would be alternates, in the event someone has to drop out.
HUNT SAFE! HUNT SMART! HAVE FUN!
REPORT ALL DEER HARVEST! PLEASE!!
Well it's official! Put my deposit in the mail today! Soft Plastic Guru should have it by Thursday!


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Home » Lifestyle » The Biggest Revelations From The 'Too Hot To Handle' Reunion — Including A Proposal
The Biggest Revelations From The 'Too Hot To Handle' Reunion — Including A Proposal
Roughly a month after rapturing the internet, Netflix's Too Hot to Handle cast reunited for a special episode to catch everyone up on what they're doing now. The show was filmed over a year ago, and a lot has changed for the contestants since then. One couple has gotten super serious, another has split, and a new, unexpected romance has even started to blossom — although the reunion didn't offer any updates about the latter.
Bryce revealed to Entertainment Tonight in late April that he and fellow contestant Nicole had forged a connection, but host Desiree Burch didn't ask about it (perhaps the reunion was filmed before Bryce broke the news?).
"Nicole and I have kind of been talking. She visited Los Angeles and we had a little bit of a thing," he told ET. "We have a great relationship, Nicole and I. She was planning on coming out [again] but with this quarantine, we're long distance technically." The two aren't official yet, but Bryce said he could maybe see that happening one day.
As for what updates the reunion did give us, here's what we learned.
Harry Proposed To Francesca
Harry and Francesca previously explained to Bustle that though they took a break for a few months after the show, they're now back together and were even talking about getting engaged, which they followed through on during the reunion.
"You've absolutely changed my life. I love you so much, and I can't wait to spend forever with you. Do you want to do this thing? Do you want to get married?" Harry asked while holding up a ring pop. Francesca said yes, and is still planning on moving to LA with Harry after the coronavirus quarantine dies down. Perhaps by then he'll have a real engagement ring. (But maybe practice the next proposal, Harry. "Do you want to do this thing?" isn't the best line.)
Harry & Francesca Got Matching Tattoos
Nothing says forever quite like permanent tattoos. Harry and Francesca each got a matching lightning bolt on their finger. "There's just so many sparks between us," Harry explained.
Sharron & Rhonda Aren't Together Anymore
Sharron and Rhonda have been trying to "make things work" since filming ended, but they haven't been able to see each other. Though they still keep in touch, they're decidedly not together…for now.
During the reunion, Rhonda got really emotional talking to Sharron, and he said at one point, "Baby, the spark's still there." So maybe there's a chance they can still work it out.
Kelz Is Single, But May Have A Celebrity Interested In Him
"Accountant" Kelz is riding out isolation by himself, but Emily Ratajkowski is apparently interested in him (at least according to Burch). Kelz joked that he can't talk about their relationship while it's so new, but it looked like he was doing the math (get it?) to see how much longer it would be before he could shoot his shot with her. Unfortunately for Kelz, Burch left out the fact that Ratajkowski is married.
Haley & Francesca Are Still Friends
Haley hated everyone on the show except for Francesca, and the two are still close today. Haley also explained that she wasn't a huge fan of the show's premise because she wasn't ready to take life that seriously yet. Maybe she will be by Season 2?
Bryce Wrote A Song
Unlike Haley, Bryce learned a lot from the retreat. He told Burch that it helped him to stop seeking so much outside validation and be more comfortable in his own skin. Now he's hunkering down on his houseboat, where he penned a tune about his time on the show. Here are the lyrics:
"This can't go on any longer, feeling like I do / thought that I was getting stronger, it's just something about you / but when you leave, you take a piece of my heart / I need to realize things and unplug and restart / this retreat's made a man out of me, I'm now somebody that I'm happy to be / so I'm taking a message to the center of my heart that I don't need your body just as sunlight to grow."
Touching.
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redpajama_set_name: RedPajamaCommonCrawl


Karen R. Harris is the Warner Professor of Education at the Mary Lou Fulton Teachers College, Arizona State University. She has taught kindergarten, fourth grade and special education students with LD and E/BD. Her research focuses on theoretically based interventions for the development of academic and self-regulation abilities among students who are at-risk and those with disabilities, as well as effective models of in-service teacher preparation for writing instruction for all students. She developed the Self-Regulated Strategy Development (SRSD) model of strategies instruction and is co-author or co-editor of several books, including Powerful Writing Strategies for All Students and Making the Writing Process Work: Strategies for Composition and Self-Regulation. She is the former editor of the Journal of Educational Psychology and senior editor of the American Psychological Association Educational Psychology Handbook (2012). Karen has served as a member of the IRA/NICHD Expert Panel on Research on the Reading-Writing Connection, which recently released the report, The Reading-Writing Connection. She has also served as President of Division 15, Educational Psychology, of the American Psychological Association and as President of the Division for Research of the Council for Exceptional Children.


Posted on November 2, 2016 April 6, 2018 by Nin Harris	Posted in Author News and Updates, Publications!
I really enjoy doing Publication Day posts not just because I get to tell the world I have a new story out, but because sometimes I get to talk a bit about the process and the backstory. Like most authors, I could probably write essays about my own stories. And it stops me from annoying people on social media by going on and on about it!
I am really happy and thrilled that Neil and Sean accepted this story. It took me a year (exactly a year!) but I am back on the Clarkesworld page! That was partially because I've dithered on finishing the stories I wrote that I filed away as "stuff that Clarkesworld would like", because there's always that fear the first time was a fluke. I mean I could have sent this in directly after "Your Right Arm" but it was at another pub (because "Your Right Arm" was in second round for a while). And then I was just. Too. Shy. To. Send. Another. Story. So. Soon.
This story is one of the oldest stories in my story folder. The idea for it came post 9-11, when the world was rent apart, when I was hurting. I had helped to look after one of my maternal aunts who, because of misdiagnosis, got to final stage of endometrial cancer before it was detected. I had learned the algebra of bereavement and guilt all caregivers undergo — especially so because my relationship with my maternal family is fraught. But my maternal aunt was always kind to me. She was the dean at the law school, and every academic term she'd give me money for my textbooks, a peptalk. I also got to do some light legal research assistant work under her.
To have that kind of history with someone you find intellectual and dynamic, to see them waste away because of cancer. That's a pain I wouldn't wish on anyone. I write this and it's not easy because I have had two separate cancer scares this year. I'm now in the clear for breast cancer but I have to go through the invasive procedures to ensure that I'm just going through early premenopausal and hormonal issues and not endometriosis or endometrial cancer.
This year, my grandmother died. And before that, before even my aunt in 2001, my maternal grandfather, (a literature, geography and history HS teacher and inspector of schools), passed away. I saw him in those heartbreaking final stages too. Felt, even as a teenager — that guilt. Why couldn't I do enough to make the people I love stay? What had I not done that I could have done so they could live?
So in 2001, my world broke. The IRC chatroom I was in for a couple of years was very close-knit, I even moderated some #mythicfolk sessions there. But when 9-11 happened, in the midst of all my bereavement, I found that in a collective shock and grief, also an anger as people I had liked turned on me because I was the only person from a third-world nation. I had gone from being a friend to being The Enemy. And that is how these things happen, really. Stories can change who you are from one minute to the next in the eyes of people.
This is my way of saying, the genesis of this tale was as a post 9-11 tale of bereavement and loss within a fraught relationship with this divide — and I wondered if love could ever be enough, if friendship could ever be enough. Or if something more was needed to heal the breach.
But eventually I decided I wanted to rewrite it, and I wanted to set it on Sesen.
So I slowly whittled away at it from year to year. A little frightened of the story but still believing in it. Then last year after I finished all of the Tower of the Rosewater Goblet stories, armed with the accelerated worldbuilding I had done for those stories (after 2-3 decades, I started writing Sesen stories when I was 14), I was finally able to work out what I wanted to say in this story, and why it was so right to set it four generations after the first human Arrivals settled in. This is a story in a world where people are still remembering, and grieving for Earth. And really, there are so many levels of grieving in here but I didn't want it to be just about that.
Like the first story I had published this year, Tower of the Rosewater Goblet, I wanted this story to be medicine, but of a more soothing kind. That story was about what happens when we have our stories and our identities taken from us (and I'm not done with this theme as it's still bugging me both epistemologically and ontologically). This story is about what stories do to us, what they wring out of us. How stories can either build walls, or become bridges.
And I hope I haven't spoiled it too much, lol.
All my love and thanks to everyone who ever read and commented on this story through its troublesome teenhood till its final maturity. Thank you. If I do not name you it is because I do not want to namedrop and presume upon your kindnesses.
What the Stories Steal, Issue #122, Clarkesworld Magazine, November 2016.


Padang is the economic centre West Sumatra. During colonial times Padang harbour was called Emmahaven, nowadays named Teluk Bayur.
Up to approximately 1780 the most important trade product was gold, originating from the gold mines in the region. When the mines were exhausted, the emphasis turned to other products such as coffee, salt and textiles. In 1797 Padang suffered from a tsunami and afterwards also quakes had been felt in the Padang region.
An important export product from the region is coal from the Ombilin mine fields in Sawahlunto. As a result of coal as fuel a cement industry has established in Padang, the so called Padang Portland cement. PT. Padang Cement is the oldest cement manufacturer in Indonesia founded in 1910.
The well known Dutch author Eduard Douwes Dekker, his writers name was Multatuli, had been resident in Padang in the 1850s.


This retro Lorna Jane crew neck tee is the perfect addition to your active or weekend wardrobe. With a vintage look and soft hand feel you will find it can be matched with any outfit, active or casual.
Featuring a slogan print transforming this tee from gym to street.


Welcome to our blog. To get more information about TMR Imagery, please visit our webiste!
If you'd like more information about setting up a shoot or about work for sale, please visit our website at www.tmrimagery.com.
Please also feel free to send an email to bookings.tmrimagery@gmail.com.
Don't get left in the dark.


text:
from cobiv.modules.core.entity import Entity
from cobiv.modules.database.backup.db_backup import JsonBackupBody, DbBackup

class SqlitedbBackup(Entity, DbBackup):
    limit = 1000

    def get_name(self=None):
        return 'sqlite_backup'

    def ready(self):
        super().ready()

        session = self.get_session()

        self.limit = int(self.get_config_value('limit', '1000'))

        # add actions
        session.set_action("dump-tags", self.dump)
        session.set_action("load-tags", self.load)

    def dump(self, path):
        body = JsonBackupBody()
        conn = self.lookup('sqlite_ds', 'Datasource').get_connection()
        with conn:
            c = conn.cursor()
            count = c.execute('select count(*) from current_set').fetchone()[0]
            for page in range((count // self.limit) + 1):
                rows = c.execute(
                    'select f.name,t.kind,t.value from file f,tag t,current_set c where c.file_key=f.id and t.file_key=c.file_key and t.category=1 and c.position>=0 order by t.file_key,t.kind limit ? offset ?',
                    (self.limit, page * self.limit)).fetchall()
                current_name = None
                tags = {}
                for name, kind, value in rows:
                    if name != current_name:
                        if current_name is not None:
                            body.files.append({'filename': current_name, 'tags': tags})
                        current_name = name
                    tags.setdefault(kind, []).append(value)
                if current_name is not None:
                    body.files.append({'filename': current_name, 'tags': tags})
        if len(body.files) > 0:
            self.dump_json(path, body)

    def load(self, path):
        body = self.load_json(path)
        if body is not None:
            conn = self.lookup('sqlite_ds', 'Datasource').get_connection()
            with conn:
                c = conn.cursor()
                tags_to_add = []
                files=body['files']
                for file in files:
                    filename = file['filename']
                    tags = file['tags']
                    row = c.execute('select id from file where name=?', (filename,)).fetchone()
                    if row is not None:
                        file_key = row[0]
                        c.execute('delete from tag where file_key=? and category=1',(file_key,))
                        for key, values in tags.items():
                            for value in values:
                                tags_to_add.append((file_key, 1, key, 0, value))

                c.executemany('insert or ignore into tag values (?,?,?,?,?)',
                              tags_to_add)

redpajama_set_name: RedPajamaGithub


When a customer enables your Alexa skill, your skill can obtain the customer's permission to use address data associated with the customer's Alexa device. You can then use this address data to provide key functionality for the skill, or to enhance the customer experience. For example, your skill could provide a list of nearby store locations or provide restaurant recommendations using this address information. This document describes how to enable this capability and query the Device Address API for address data.
Note that the address entered in the Alexa device may not represent the current physical address of the device. This API uses the address that the customer has entered manually in the Alexa app, and does not have any capability of testing for GPS or other location-based data.
For information on how to request customer contact information including name, email address, and phone number, see Request Customer Contact Information for Use in Your Skill.
To protect customer data, any skill that uses device address information must meet the requirements below. If Amazon determines that your skill violates any of these requirements, we will reject or suspend your submission and notify you using the email address associated with your developer account.
Your skill must not be a child-directed skill. See here for more information on child-directed skills.
You must request permission to receive address information only when required to support the features and services provided by your skill. You must use any personal information you request only as permitted by the user and in accordance with your privacy notice and applicable law.
You must not use device address information to link the customer's account in the background. That is, you must not associate an Alexa customer to a customer in your account pool with the same address information.
The skill must call the Device Address API to get the latest customer information every time the customer invokes the skill with a request that needs this information.
Configure your skill in the developer console to indicate that it requires address information. As a result, the customer is prompted, with a permissions card in the Alexa app to consent to provide the customer's address information when they configure your skill.
For reference, here is what the customer sees when prompted for permissions in the Alexa app. In this example, the skill has been configured for permissions to ask for the full address, so that is what is shown on the card.
Obtain the deviceId and apiAccessToken from the Alexa launch request message when a customer invokes the skill.
Send a message to the correct address endpoint that includes the apiAccessToken and deviceId, as described in Get Country/Region and Postal Code and Get Address.
Navigate to the Build > Permissions page.
Select Device Address, and either Full Address or Country/Region & Postal Code Only, depending which your skill uses.
See also: Build Your Skill: Permissions.
Each request sent to your skill includes an API access token (apiAccessToken) that encapsulates the permissions granted to your skill. You need to retrieve both this token and the device ID (deviceId) and include them in requests for the customer's "Full Address" or "Country/Region & Postal Code".
Both the apiAccessToken and device ID deviceId values are nested in the System object, which is nested in the context object. To see the full body of the request, refer to Request Format.
Important: Requests from Alexa may also include a consentToken within session.user.permissions and context.System.user.permissions. This property is deprecated. Existing skills that use consentToken continue to work, but the context.System.apiAccessToken property should be used instead.
The apiAccessToken is included on all requests to your skill, regardless of whether the user granted your skill the permissions needed to fulfill the request. Therefore, the token may not contain the right set of permissions for your skill to fulfill the request. Your skill can display a special permissions card to ask customers for consent dynamically.
Attributes permissions: this contains a list of scope strings that maps to Alexa permissions. Include only those Alexa permissions that are both needed by your skill and that are declared in your skill metadata on the Amazon Developer Portal.
Because apiAccessToken is included in all skill requests, you cannot use the presence of apiAccessToken to determine whether or not you have the needed permissions. Instead, call the API and check the response code. A 403 Forbidden response indicates that your skill does not have the permissions, so at that point you can include the AskForPermissionsConsent card in your response to Alexa.
An in-session interaction can return a response that includes the new AskForPermissionsConsent card.
Here is a sample response for a card with a request for a full address.
If the request was for the country/region and postal code, then the permissions value in this response will be "read::alexa:device:all:address:country_and_postal_code".
The permissions value will always match the scope that you declared for the skill on the Build > Permissions page in the Amazon Developer Portal.
You can do limited testing on the Test page in the developer console. When testing with the Alexa Simulator, your skill can call the Device Address API and get back a non-error response. You can also test the flow when the user has not provided the device address permission.
The Test page cannot be configured as a full device in the Alexa app. An actual device is recommended for comprehensive testing.
To test the case where the customer has provided permissions to your skill, ensure that you have enabled the address permissions for your skill in the Alexa companion app. When you open the skill ("Alexa, open skill_name"), that will cause a LaunchRequest to be sent. If the permissions have been enabled, you can obtain the deviceId and the apiAccessToken from the request.
To test the case where the customer has not provided permissions to your skill, ensure that the address permissions for your skill in the Alexa companion app are not enabled. When you open the skill ("Alexa, open skill_name"), that will cause a LaunchRequest to be sent. This request will contain the deviceId value and the apiAccessToken value, but the apiAccessToken will not specify the correct permissions. Passing this token to the Device Address API will return a 403 Forbidden response code.
For more information about testing with a device, see: Test Your Skill.
After the customer enables your skill, the customer is prompted to consent to providing address information from within the Alexa app, whether that is the full address or the country/region and postal code.
If the customer does not consent, you are encouraged to include a graceful fallback message in your code.
Your skill can be developed so that some functionality is available without address information being provided, or it can be developed so that no functionality is provided without address information.
"You have refused to allow skill_name access to the address information in the Alexa app. skill_name cannot function without address information. To permit access to address information, consent to provide address information in the Alexa app."
"You have refused to allow skill_name access to the address information in the Alexa app. skill_name will have limited functionality without this information. To permit skill_name to have address information, enable skill_name again, and consent to provide address information in the Alexa app."
The examples in this document use the US endpoint (https://api.amazonalexa.com/).
For more about configuring your skill for multiple languages, see Develop Skills in Multiple Languages.
Gets the country/region and postal code associated with a device specified by deviceId. The endpoint is case-sensitive.
This example shows a successful response for a request for "Country/Region & Postal Code".
X-Amzn-RequestId Unique identifier for the request. If a problem occurs, Amazon can use this value to troubleshoot the problem.
200 OK Successfully retrieved the country/region and postal code associated with the deviceId.
204 No Content The query did not return any results.
403 Forbidden The authentication token is invalid or doesn't have access to the resource.
404 Not Found The given URI is not able to locate a resource, for example because the deviceId is not valid.
405 Method Not Allowed The method is not supported.
429 Too Many Requests The skill has been throttled due to an excessive number of requests.
500 Internal Error An unexpected error occurred.
Gets the full address associated with the device specified by deviceId.
200 OK Successfully got the address associated with this deviceId.
The customer may grant or reject the request for device address information.
If a skill asks for address information for which the customer has not granted permissions, then the skill will receive an error.
When your skill requests the customer's device address information, and the customer grants it, this information may still be unavailable, such as if a customer has not provided address information to Alexa. In that case, you may receive specific default values, as described below.
If the customer has not supplied the device address information or if the postal code is military related, then a default postalCode value of "98109" may be returned.
The device address information will be obtained from the customer's Amazon account settings, if possible. If no information can be obtained, then a null value is returned.
As a skill developer, you can determine the appropriate response when your customer does not provide address information.
You can provide a graceful fallback message that indicates the skill cannot function without this information, and end the session.
Alternatively, you can provide a message that indicates that the skill will continue to work, but with reduced functionality compared to having the requested address information.
For a good customer experience, ensure that you consider the skill workflow in all of the scenarios in which you fail to get the desired device address information.


text:
News Sports Opinion Obituaries USA TODAY eNewspaper Legals
Victorville not out of the woods yet
Brooke Edwards
VICTORVILLE • Even as the city starts this fiscal year with a balanced budget, officials are advising that Victorville isn't out of the woods yet.
"I want to caution the council, we are using $4.7 million in reserves in order to balance this budget," Deputy City Manager Doug Robertson said during the city's recent budget workshop. "So in essence between now and June 30 of next year we need to see revenue increases and expenditure decreases that equal $4.7 million or we'll have to make further cuts of some type."
When Councilwoman JoAnn Almond asked whether the city is done laying off employees, City Manager Jim Cox said, "We believe we're through."
The city's general fund reserves, use to cover temporary shortfalls or unexpected drops in revenue, were at $22 million as of July 1, 2007. One year later they'd dropped to $12 million, with much of that money being used to cover losses from Victorville's attempts at generating electricity for businesses.
Now just $2.5 million is left in the city's reserves fund, while Councilman Ryan McEachron said they're heading into what could be an even worse fiscal year than the one that just ended when it comes to property and sales tax, which, combined, make up roughly 70 percent of the general fund.
"Unfortunately I'm concerned that this is not the end of it," McEachron said.
To read the full story, see Thursday's Daily Press. To subscribe to the Daily Press in print or online, call (760) 241-7755, 1-800-553-2006 or click here.
Brooke Edwards may be reached at (760) 955-5358 or at bedwards@VVDailyPress.com.
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text:
Your search: "author:"French, Jacqueline""
BY - Attribution required (1)
The role of inflammation in epilepsy.
Vezzani, Annamaria;
Bartfai, Tamas;
Baram, Tallie Z
UC Irvine Previously Published Works (2011)
Epilepsy is the third most common chronic brain disorder, and is characterized by an enduring predisposition to generate seizures. Despite progress in pharmacological and surgical treatments of epilepsy, relatively little is known about the processes leading to the generation of individual seizures, and about the mechanisms whereby a healthy brain is rendered epileptic. These gaps in our knowledge hamper the development of better preventive treatments and cures for the approximately 30% of epilepsy cases that prove resistant to current therapies. Here, we focus on the rapidly growing body of evidence that supports the involvement of inflammatory mediators-released by brain cells and peripheral immune cells-in both the origin of individual seizures and the epileptogenic process. We first describe aspects of brain inflammation and immunity, before exploring the evidence from clinical and experimental studies for a relationship between inflammation and epilepsy. Subsequently, we discuss how seizures cause inflammation, and whether such inflammation, in turn, influences the occurrence and severity of seizures, and seizure-related neuronal death. Further insight into the complex role of inflammation in the generation and exacerbation of epilepsy should yield new molecular targets for the design of antiepileptic drugs, which might not only inhibit the symptoms of this disorder, but also prevent or abrogate disease pathogenesis.
Clinical studies and anti-inflammatory mechanisms of treatments.
French, Jacqueline A;
Koepp, Matthias;
Naegelin, Yvonne;
Vigevano, Federico;
Auvin, Stéphane;
Rho, Jong M;
Rosenberg, Evan;
Devinsky, Orrin;
Olofsson, Peder S;
Dichter, Marc A
In this exciting era, we are coming closer and closer to bringing an anti-inflammatory therapy to the clinic for the purpose of seizure prevention, modification, and/or suppression. At present, it is unclear what this approach might entail, and what form it will take. Irrespective of the therapy that ultimately reaches the clinic, there will be some commonalities with regard to clinical trials. A number of animal models have now been used to identify inflammation as a major underlying mechanism of both chronic seizures and the epileptogenic process. These models have demonstrated that specific anti-inflammatory treatments can be effective at both suppressing chronic seizures and interfering with the process of epileptogenesis. Some of these have already been evaluated in early phase clinical trials. It can be expected that there will soon be more clinical trials of both "conventional, broad spectrum" anti-inflammatory agents and novel new approaches to utilizing specific anti-inflammatory therapies with drugs or other therapeutic interventions. A summary of some of those approaches appears below, as well as a discussion of the issues facing clinical trials in this new domain.
The challenge and promise of anti-epileptic therapy development in animal models.
Simonato, Michele;
Brooks-Kayal, Amy R;
Engel, Jerome;
Galanopoulou, Aristea S;
Jensen, Frances E;
Moshé, Solomon L;
O'Brien, Terence J;
Pitkanen, Asla;
Wilcox, Karen S;
French, Jacqueline A
Translation of successful target and compound validation studies into clinically effective therapies is a major challenge, with potential for costly clinical trial failures. This situation holds true for the epilepsies-complex diseases with different causes and symptoms. Although the availability of predictive animal models has led to the development of effective antiseizure therapies that are routinely used in clinical practice, showing that translation can be successful, several important unmet therapeutic needs still exist. Available treatments do not fully control seizures in a third of patients with epilepsy, and produce substantial side-effects. No treatment can prevent the development of epilepsy in at-risk patients or cure patients with epilepsy. And no specific treatment for epilepsy-associated comorbidities exists. To meet these demands, a redesign of translational approaches is urgently needed.
Classification of the epilepsies: New concepts for discussion and debate-Special report of the ILAE Classification Task Force of the Commission for Classification and Terminology.
Scheffer, Ingrid E;
Hirsch, Edouard;
Jain, Satish;
Mathern, Gary W;
Perucca, Emilio;
Tomson, Torbjorn;
Wiebe, Samuel;
Zhang, Yue-Hua;
Zuberi, Sameer M
The ILAE Task Force on Classification presents a road map for the development of an updated, relevant classification of the epilepsies. Our objective is to explain the process to date and the plan moving forward as well as to invite further discussion about the newly proposed terms and concepts. Here, we present our response to feedback about the 2010 Organization of the Epilepsies and clarify the reintroduction of the word "classification" to map out a framework for epilepsy diagnosis. We introduce some new concepts and suggest four diagnostic levels: seizure type, epilepsy category, epilepsy syndrome, and epilepsy with (specific) etiology to denote specific levels of diagnosis. We expand the etiological categories to six, focusing on those with treatment implications. Finally, we discuss the changes in terminology originally suggested and modifications in response to comments from the epilepsy community. We welcome feedback and discussion from the global epilepsy community, particularly for the new suggested terms, so that we can cement a classification that both reflects current thinking and scientific understanding and provides a dynamic, evolving framework.
Detection of epileptogenic cortical malformations with surface-based MRI morphometry.
Thesen, Thomas;
Quinn, Brian T;
Carlson, Chad;
DuBois, Jonathan;
McDonald, Carrie R;
Leventer, Richard;
Felsovalyi, Olga;
Wang, Xiuyuan;
Halgren, Eric;
Kuzniecky, Ruben
Magnetic resonance imaging has revolutionized the detection of structural abnormalities in patients with epilepsy. However, many focal abnormalities remain undetected in routine visual inspection. Here we use an automated, surface-based method for quantifying morphometric features related to epileptogenic cortical malformations to detect abnormal cortical thickness and blurred gray-white matter boundaries. Using MRI morphometry at 3T with surface-based spherical averaging techniques that precisely align anatomical structures between individual brains, we compared single patients with known lesions to a large normal control group to detect clusters of abnormal cortical thickness, gray-white matter contrast, local gyrification, sulcal depth, jacobian distance and curvature. To assess the effects of threshold and smoothing on detection sensitivity and specificity, we systematically varied these parameters with different thresholds and smoothing levels. To test the effectiveness of the technique to detect lesions of epileptogenic character, we compared the detected structural abnormalities to expert-tracings, intracranial EEG, pathology and surgical outcome in a homogeneous patient sample. With optimal parameters and by combining thickness and GWC, the surface-based detection method identified 92% of cortical lesions (sensitivity) with few false positives (96% specificity), successfully discriminating patients from controls 94% of the time. The detected structural abnormalities were related to the seizure onset zones, abnormal histology and positive outcome in all surgical patients. However, the method failed to adequately describe lesion extent in most cases. Automated surface-based MRI morphometry, if used with optimized parameters, may be a valuable additional clinical tool to improve the detection of subtle or previously occult malformations and therefore could improve identification of patients with intractable focal epilepsy who may benefit from surgery.
The evolution of epilepsy surgery between 1991 and 2011 in nine major epilepsy centers across the United States, Germany, and Australia.
Jehi, Lara;
Friedman, Daniel;
Cascino, Gregory;
Dewar, Sandra;
Elger, Christian;
Knowlton, Robert;
Kuzniecky, Ruben;
McIntosh, Anne;
Spencer, Dennis;
Sperling, Michael R;
Worrell, Gregory;
Bingaman, Bill;
Gonzalez-Martinez, Jorge;
Doyle, Werner;
French, Jacqueline
Epilepsy surgery is the most effective treatment for select patients with drug-resistant epilepsy. In this article, we aim to provide an accurate understanding of the current epidemiologic characteristics of this intervention, as this knowledge is critical for guiding educational, academic, and resource priorities.
We profile the practice of epilepsy surgery between 1991 and 2011 in nine major epilepsy surgery centers in the United States, Germany, and Australia. Clinical, imaging, surgical, and histopathologic data were derived from the surgical databases at various centers.
Although five of the centers performed their highest number of surgeries for mesial temporal sclerosis (MTS) in 1991, and three had their highest number of MTS surgeries in 2001, only one center achieved its peak number of MTS surgeries in 2011. The most productive year for MTS surgeries varied then by center; overall, the nine centers surveyed performed 48% (95% confidence interval [CI] -27.3% to -67.4%) fewer such surgeries in 2011 compared to either 1991 or 2001, whichever was higher. There was a parallel increase in the performance of surgery for nonlesional epilepsy. Further analysis of 5/9 centers showed a yearly increase of 0.6 ± 0.07% in the performance of invasive electroencephalography (EEG) without subsequent resections. Overall, although MTS was the main surgical substrate in 1991 and 2001 (proportion of total surgeries in study centers ranging from 33.3% to 70.2%); it occupied only 33.6% of all resections in 2011 in the context of an overall stable total surgical volume.
These findings highlight the major aspects of the evolution of epilepsy surgery across the past two decades in a sample of well-established epilepsy surgery centers, and the critical current challenges of this treatment option in addressing complex epilepsy cases requiring detailed evaluations. Possible causes and implications of these findings are discussed.
ILAE official report: a practical clinical definition of epilepsy.
Fisher, Robert S;
Acevedo, Carlos;
Arzimanoglou, Alexis;
Bogacz, Alicia;
Cross, J Helen;
Elger, Christian E;
Forsgren, Lars;
Glynn, Mike;
Hesdorffer, Dale C;
Lee, BI;
Tomson, Torbjörn;
Watanabe, Masako;
Wiebe, Samuel
Epilepsy was defined conceptually in 2005 as a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures. This definition is usually practically applied as having two unprovoked seizures >24 h apart. The International League Against Epilepsy (ILAE) accepted recommendations of a task force altering the practical definition for special circumstances that do not meet the two unprovoked seizures criteria. The task force proposed that epilepsy be considered to be a disease of the brain defined by any of the following conditions: (1) At least two unprovoked (or reflex) seizures occurring >24 h apart; (2) one unprovoked (or reflex) seizure and a probability of further seizures similar to the general recurrence risk (at least 60%) after two unprovoked seizures, occurring over the next 10 years; (3) diagnosis of an epilepsy syndrome. Epilepsy is considered to be resolved for individuals who either had an age-dependent epilepsy syndrome but are now past the applicable age or who have remained seizure-free for the last 10 years and off antiseizure medicines for at least the last 5 years. "Resolved" is not necessarily identical to the conventional view of "remission or "cure." Different practical definitions may be formed and used for various specific purposes. This revised definition of epilepsy brings the term in concordance with common use. A PowerPoint slide summarizing this article is available for download in the Supporting Information section here.


text:
Farewell Etios, hello Starlet - Meet Toyota's new affordable star
Janine Van der Post
• Toyota and Suzuki launch their first model from its joint venture.
• The Toyota Starlet is based on the Suzuki Baleno.
• Pricing for the B-segment offering starts from R204 900.
• For more motoring stories, go to www.Wheels24.co.za
Toyota has launched its brand new Starlet on Monday (21 September), its first product from its joint venture with Suzuki which was announced in 2019.
The Starlet is a 'funky' and modern new offering from Toyota and is also a replacement to the now-discontinued Etios. But in short, it's a Suzuki Baleno with a Toyota badge, a slightly largely line-up, and a new name - and it's also more affordable than it's twin sister.
Production for the Etios ended earlier in March this year. Direct rivals for the new Starlet, which is Suzuki's version of the Baleno, is the Ford Figo, Volkswagen Polo Vivo and Renault Sandero.
Toyota's senior vice-president of sales and marketing Leon Theron says: "On 28 August 2019, Toyota and Suzuki announced a formal alliance between the two companies, in order to leverage each other's strengths and compete in the evolving global vehicle market. Toyota's expertise in Hybrid technology and autonomous driving would be of benefit to Suzuki, while Toyota would get access to compact vehicles, a Suzuki strength. A mutually-beneficial alliance was born."
The automaker says the Starlet name dates back to 1973, and has adorned Toyota's sub-compact hatchback in the Japanese Domestic Market for five generations (ending in 1999). Staying true to the ethos of being a compact, efficient and value-focused product, the newcomer proudly revives the Starlet badge.
These joint ventures are also nothing new to Toyota who launched the new Supra last year in collaboration with BMW, along with another project with Daihatsu.
Image: Motorpress/ Cornel Van Heerden
Theron also says motor companies are under tremendous pressure worldwide and as OEMs, they have to think out of the box. There are numerous mobility factors being offered to customers which include not having to purchase a vehicle. The Starlet plays into the hands of the B-segment and will attract younger customers such as those finishing up at university or young married couples.
With a tag line of 'Make space for fun', the automaker says the new model is affordable to run, has a great infotainment system, includes Toyota Connect, Android Auto, and CarPlay.
Here's how the new. @ToyotaSA Starlet compares to the @VolkswagenSA Polo Vivo. pic.twitter.com/silmhmywGO
— Wheels24 (@Wheels24) September 21, 2020
Joy Mibela, manager marketing planning says the sub-B segment makes up for about 34% of the market and the B-segment equoates to 43% market share. The Starlet, she says, is a stylish little car, sociable, and has an attractive price, as well as good styling, and makes for a sensible choice.
The Etios was launched in 2012, and sold about 1125 units monthly, according to the automaker. However, its styling has become outdated, there was no VSC and a lack of an auto transmission played a huge part in current needs for consumers.
The Starlet and Suzuki's Baleno can be differentiated by the V-shaped front grille and the badging. The automaker says the exterior design follows a classic hatchback profile, with a short, downward-sloping nose and rounded-off rear hatch. The front grille in Toyota-specific finishing has centrally-mounted Toyota insignia, and features two vertically-arranged headlights with chrome inserts. A trapezoidal lower air dam is flanked by fog light housings (where fitted).
Toyota also says the side profile features contour-following upper and lower crease lines – with no sharp edges - and colour-coded exterior mirrors.
The rear design centres around the large LED tail lights with red and translucent accents. There's also a chrome garnish strip and trapezoidal indent in the lower bumper section.
Toyota reckons spaciousness and ergonomics without compromise was a priority for the interior. The centre 'hang-down' section of the dashboard neatly groups the ventilation, infotainment and climate-control switchgear, says Toyota. The instrument cluster is bright and easy-to-read with on-centre Multi-Information Display (MID) and dual analogue gauges.
A chunky three-spoke steering wheel incorporates steering switches and cruise control (where equipped).
What's under the bonnet?
The Starlet houses a 1.4-litre DOHC four-cylinder engine featuring Variable Valve Timing (VVT) and a tumble-flow intake manifold. Power output is pegged at 68kW at 6000rpm with 130Nm at 4200rpm.
Two transmission choices are on offer, a five-speed manual and four-speed automatic, all driving the front wheels. The obligatory 0-100km/h dash is dispatched in 10.9s for the manual and 11.6s for the auto variant.
Toyota claims fuel consumption figures between 5.1-litres/100km for the manual version and 5.4-litres/100km for the auto models. A 37-litre fuel tank provides an effective range of over 700km on a single tank.
Toyota says the foundation of the Starlet is Suzuki's TECT platform, which utilises high-tensile steel in critical areas as well as energy absorption channels – to produce a strong, safe and lightweight chassis. A traditional McPherson strut front-suspension design is joined by a torsion-beam rear axle. The torsion-beam layout provides enhanced packaging and contributes to the Starlet's spaciousness.
The Xi model is equipped with 15"-steel wheels shod with 175-65R15 tyres and a space- saver spare wheel. Xs and Xr variants feature stylish turbine-shaped 16"-alloy wheels with 185-55R16 rubber.
Toyota says the towing capacity weighs in at 400kg unbraked and 1000kg braked.
Grade Strategy and Specification
Image: Toyota
All Starlet models are also equipped with the Toyota Connect telematics system which includes an in-car Wi-Fi hotspot and complimentary 15Gb data. Once linked to their profile, customers can manage their vehicle via the MyToyota App. This intuitive app allows on-demand service bookings, vehicle information and history, tracking data as well as Toyota Connect data recharge services and much more.
According to Toyota, yes based on the following: all Starlet models come with safety and security equipment which include active electronic aids such as ABS, EBD, Brake Assist (BA) and Vehicle Stability Control (VSC). Automatic transmission models also include Hill Assist Control (HAC).
Xi and Xs models are fitted with Driver and Passenger (D+P) airbags, while the Xr variants also feature Curtain and Side airbags (C+S). Two ISOFIX points and a security system are provided across the board.
Starlet 1.4 Xi MT – R204 900
Starlet 1.4 Xs MT – R215 200
Starlet 1.4 Xs AT – R235 700
Starlet 1.4 Xr MT – R258 500
Starlet 1.4 Xr AT – R272 500
All Starlet models are sold with a three services or 45 000km service plan – with 15 000 km service intervals. A three-year or 100 000km warranty is also provided. Customers can purchase an additional service plan and warranty extensions from their local Toyota dealer – and of they benefit from the biggest dealer network in the country (over 220).
. @ToyotaSA launches its new Starlet today, here's pricing for the model. pic.twitter.com/1gsMGMlL96
REVIEW | The Toyota Corolla Quest is a fine car and friendly on the wallet too
How Toyota's Quantum has been redesigned as a classic HiAce taxi
This is Toyota's outrageous racing version of its upcoming hybrid hypercar
toyotasuzukitoyota starletbest car dealsbudget carsnew model


All data in Version 1.0 were audited prior to publication.
An error in the units for riboflavin and folic acid for some of the datasets was corrected and electronic software for screening future datasets was developed to eliminate a similar reoccurrence.
Additional conventional corn, cotton and soybean composition data were added.
The database was restructured for increased functionality, speed and efficiency; and was migrated to a new platform which required that all raw data files be reexamined for compliance with the ILSI data acceptance criteria and reentered into the database. Only raw data files meeting all acceptance criteria were included in v4.0. Performance, security, availability and scalability were improved. Amino acid and fatty acid data became available in multiple units of measure, including % FW, % DW, % Total, and mg/g. To aid in the interpretation of data output, data summaries were enhanced to include the number of values for analytes below the LOQ and report output as Excel and PDF files became available. No new data were incorporated into the database in this release.
Additional secondary Units of Measure were added for some of the vitamins.
Unit of measure conversion errors (mg/g FW to mg/g DW and mg/g FW to % DW) were corrected.
A unit of measure conversion error for inositol (ug/g to ppm) was corrected.
The functionality of the data preview tool was corrected to eliminate inadvertent doubling of all sample numbers (i.e., N).
Eight data points incorrectly entered as asparagine in cotton acid-delinted seed were corrected to aspartic acid. This did not alter the minimum aspartic acid value in cotton acid-delinted seed, but the maximum value was increased from 26.1 to 27.3 mg/g FW. The mean was also increased from 21.96 to 22.15 mg/g FW and the total number of samples was updated to 143.
A Captcha was added to the registration page.
Version 5.0 has seven times more data points than the previous version. New data includes nutritional data from new crops canola, corn sweet and rice and additional data on existing crops (corn field, soybean and cotton). New crops required the addition of new analytes that are specific to the crops.
In previous versions of the database (Version 3.0 and before) data was uploaded manually by a Data Curator, who inspected the data files received from the data providers and ensured data integrity and consistency before depositing it in the database. Version 5.0 features improvements to the database software including implementation of a Data Provider tool for automated upload and validation of data and a Data Curator tool that allows the Data Curator to manage the database. These tools automate the process of data upload and validation to increase the efficiency of data upload and reduce the potential for errors.
Version 5.0 implements an important feature for standardization and consolidation of existing analytical methods along with an optimized process for the addition of methodology associated with new data. In the past, as new or updated methods were employed for nutritional analysis, the method references were assigned codes for internal use within the database. The assignment of the method codes was sequential and sometimes resulted in multiple codes for methods that were essentially identical. For example, some method codes for Association of Analytical Communities (AOAC) or American Association of Cereal Chemists (AACC) methods differed only by the year of publication although the analytical methodology was unchanged. To achieve greater clarity in the relationship between existing data and the associated method references, a standardized format for scientific literature references was adopted. Defining standardized formats facilitates faster data upload, data retrieval and ensures data integrity. The references for all existing data were converted to this format, and then all data of identical crop, tissue, analyte, and analytical methodology were combined. This eliminated duplication of method references, thus, providing a more realistic view of the number of data points associated with any particular method. For simplification and as an aid to prevent duplication in future data submissions, a new numbering system was created. Within this system, the new method code is comprised of six alpha-numeric placeholders with the first two characters being letters that represent the analyte category (e.g. AA for amino acids, BA for bioactives, VT for vitamins, etc.) and the remaining four characters representing a sequentially assigned number within each category. After consolidation based on literature references, all existing methods were assigned codes based on this system, as were new methods required for submission of data to be published in Version 5.0. New method codes for data submissions are requested of, and generated by, the database curator, and are assigned in consultation with an analytical expert.
The primary units of measure displayed in the Summary of Search Results table have been changed from Fresh Weight (FW) to Dry Weight (DW). Fresh Weight units of measure may be selected in the Create Report from Search Results table, if so desired.
The Version 6.0 update included nutritional data from two new crops, potato (Solanum tuberosum) and sorghum (Sorghum bicolor) and additional data on the following existing crops: canola, cotton, field corn, and soybean. Additionally, two units of measure conversion errors for alpha tocopherol were corrected.
Some canola data sets were temporarily removed from Version 6.0 for correction of method codes. These data sets were unavailable from November 3, 2018 through November 29, 2018.
The Version 6.1 update includes all canola data sets with changes made to correct the method codes for some analytes in the category Bio Actives and Glucosinolates. These changes had no effect on data values, ranges or reported units of measurement.
For all canola sinapine data with method code BA0015, the method code was changed to BA0018.
For all canola total tannins data with method code BA0015, the method code was changed to BA0019.
For all canola total glucosinolates, total alkyl glucosinolates and total indolyl glucosinolates data with method code BA0015, the method code was changed to BA0017.
The Version 7.0 update includes compositional data from a new crop, apple (Malus domestica), with data for three apple varieties (Golden Delicious, Granny Smith and Fuji), which are categorized as tissue types in the database.
The size of the data sets for the existing crops canola, cotton, field corn, potato, rice and soybean were increased.
Rice compositional data was added for the tissue type bran.
It was determined that the inositol data should be classified as free inositol or total inositol based on the analytical method. In version 7.0 all the 4714 inositol data points from version 6.1 were recoded. 1612 data points associated with method code ME0006 were recoded from inositol to free inositol, and 3102 data points associated with method code ME0001 were recoded from inositol to total inositol.


Make the kind of impact we make for clients, only for Deloitte itself.
Whether you're looking to make your impact in marketing, IT, HR, legal, risk management, or administration, it's likely to happen faster and more fully if you choose an organization that offers diverse opportunities and a culture of leadership, collaboration, and innovation. Welcome to Deloitte.
Deloitte has more than 75,000 employees and is a $16 billion-plus organization in the United States. Needless to say, we need the kind of services any large organization does and we need the people we hire to perform at a high level. Professionals in Internal Services work in a wide range of careers—accounting, tax, in-house counsel, brand, design, HR, IT, technology development, and more—but we share a common purpose. We help Deloitte deliver measurable, lasting results for our internal stakeholders and make an impact that matters. Here are a few ways Internal Services fuels Deloitte's ability to achieve its goals.
Culture: In professional services, our people are our greatest asset. Our talent, recruiting, and HR professionals keep Deloitte on the forefront as an employer. They help shape our inclusive culture. They develop innovative approaches to work and benefits. They lead our training centers like Deloitte University.
Innovation: As a leader in applied technology from cloud computing to workforce mobility to analytics, Deloitte walks the talk. Our technology teams help develop advanced analytics tools, design multimedia software, architect, and maintain our own network systems, and keep us connected and humming along. Beyond the tech, our people also innovate new methodologies through offerings like Deloitte Greenhouse and we bring original research to the table at our industry-focused Innovation Centers like the Silicon Valley-based Deloitte Center for the Edge.
Reputation: Many things influence an organization's reputation. Our brand, marketing, and communications teams are certainly front and center in shaping reputation through advertising, sales materials, and websites, as well as the thought leadership pieces produced from Deloitte Insights. But every bit as important are internal groups like regulatory risk and our Office of General Counsel that protect the reputation Deloitte has built—one of independence, quality, and ethical integrity.
Stability and efficiency: Stability and efficiency are essential to the work Deloitte does. Stability comes in many forms, from financial operations to talent management to leadership development. But stability doesn't mean standing still; our collaborative, transparent, and technology-enabled approach supports meaningful change anchored by our stable environment. Efficiency in operations is critical too. Our administrative staff is essential to ensuring our offices run smoothly and that we are focused on appropriate sustainability initiatives.
In the same way we look for opportunity on behalf of clients, Deloitte looks for opportunity for itself—technologies that spawn insights and efficiencies, programs that attract and retain talent, media tactics that reach new audiences. All of it serves the greater impact we can make as Deloitte.
Technology and communications impact Internal Services careers. Our people work with some of the most advanced tools for their given professions. We're hiring more professionals with technology backgrounds than ever before to address business needs ranging from marketing and business development to human resources and administration to finance and legal. From a communications perspective, working in Internal Services calls upon our professionals' strong abilities in listening to and sharing vital information in a rapidly changing work world.


Captain William Stanaforth is on a solo mission to Mars, with a goal of taking the first step of colonizing it. Even if the entire world is watching him, Strong is completely alone in a distant sea of stars. As he bravely rockets through space, he is faced with impossible life and death choices.


text:
Cute Endangered Animal: Kangaroo Rat
This week's cute endangered animal is the kangaroo rat. Now you might not think that any animal with "rat" in its name would be cute, or in danger of disappearing, but both are true for several species of kangaroo rats here in the U.S. Despite its name, the kangaroo rat is not actually a rat, but rather a relation the gopher family. Currently, six species of kangaroo rats (genus Dipodomys) are facing extinction. They all live in the Western half of the US, starting in the Dakotas and extending West to California and Nevada, preferring desert habitats. The tiny animals measure just 2″ at the shoulder, and like to get around by hopping like kangaroos (as much as 6″ a leap!). Kangaroo rats are known for their love of dust baths, for cramming an incredible amount of food into their cheek pouches and, on occassion, for hiding under the crotches of hapless biologists.
The native kangaroo rat was thriving until the 1950s, when a two-tiered threat of agriculture and human development hit them: the farmers carried out pest-control campaigns against the rats (who found newly-tilled soil perfect for burrows), and new roads made it hard for rats to find new habitat. More recently, oil and natural gas exploration has been painted as a possible culprit in a number of rat deaths. Also, given that the rats relate their mating status and territory by thumping their long hind legs on the ground, one can only imagine that development also hinders intra-species communication.
The kangaroo rats' survival is important to environmentalists because the animals are a "keystone species" in their environments. With kidneys four times as strong as humans', kangaroo rats get most of their daily moisture from their food: seeds and nuts. By eating plants with the largest seeds, they allow plants with smaller seeds to flourish, which in turn effects the surrounding insect and bird populations.
Despite their importance to the ecosystem, the federal government has not been pro-active in protecting the kangaroo rat. Just last year, US Fish & Wildlife proposed cutting a California kangaroo rat's protected habitat by about 2/3. Conservation groups said they were going to sue the department, and Fish & Wildlife relented by changing the planned habitat reduction. Scientists said last year that they will use an Israeli satellite to take pictures of the rats habitat which will help them get an accurate population count. Though just how accurate the satellites will be remains unknown. "It's fairly rare for something so small to be a keystone species," UC Berkeley's Tim Bean told USA Today. "It's easier to track, say, bison."


text:
Howard Philips Smith
Southern Decadence in New Orleans
Louisiana State University Press 2018
Almost a year ago, on my second interview for this podcast, I talked to Howard Philips Smith about Unveiling the Muse: The Lost History of Gay Carnival in New Orleans. I invited him back to tell us about his follow up book: Southern Decadence in New Orleans. Co-written with Frank Perez (the president of the LGBT+ Archives Project of Louisiana) and published by the Louisiana State University Press in 2018, Southern Decadence in New Orleans provides the first comprehensive historical look at another important event in the Crescent City's LGBTQ+ calendar. Commonly referred to as "Gay Mardi Gras," the Southern Decadence festival began in 1972 as a spontaneous end-of-the-summer celebration of a group of friends who felt like outcasts because of their political views, sexual orientation, and/or racial identity. Over the last four decades, it has transformed into a gay extravaganza lasting almost a full week and culminating on a grand parade on the Sunday before Labor Day. It attracts hundreds of thousands of revellers from all over the world and is one of the city's largest (and most lucrative) annual events. Smith and Frank combined interviews, participant observation, and archival materials to do document the trajectory of this fascinating phenomenon.
Dr Isabel Machado is a Postdoctoral Fellow in Gender and Sexuality Studies at the Department of History of the University of Memphis. Her forthcoming book uses Carnival as a vehicle to understand social and cultural changes in Mobile, Alabama (USA) in the second half of the 20th century. Her new research project is an investigation of different generations of artists and performers who challenge gender normativity in Monterrey, Nuevo León (Mexico). She also works as an Assistant Producer for the Sexing History podcast.
Isabel Machado
Also Hosted By Isabel Machado
A Sojourn in Paradise
Prismatic Performances
April Sizemore-Barber
Doing Gender in Events
Barbara Grabher
Queer Nightlife
Kemi Adeyemi, Kareem Khubchandani and Ramon H. Rivera-Servera
In Between Subjects
Amelia Jones
Disturbing Spirits
Beverly A. Tsacoyianis
Translocas
Lawrence La Fountain-Stokes
Rahul Rao
João José Reis
Sadomasochism and the BDSM Community in the United States
Stephen K. Stein
After the Dance, the Drums Are Heavy
Rebecca Hope Dirksen
Public Performances
Jack Santino


text:
Q: Get the values of between two string with using substring? I want to get all of the values which is matches in a some string with using substring?
I gave the some code which finds the only one result. I need all of matches..
İs it possible?
int pFrom = icrasorgula_cevap.IndexOf("<dosyaId>") + "<dosyaId>".Length;
int pTo = icrasorgula_cevap.LastIndexOf("</dosyaId>");

string result = icrasorgula_cevap.Substring(pFrom, pTo - pFrom);

<root>
<object-array>
    <object-array>
        <DVOList>
            <liste>
                <AvukatDosyaKisiDVO>
                    <birimId>105344286</birimId>
                    <birimAdi>Merkezi Takip Sistemi</birimAdi>
                    <dosyaNo>2019/15333</dosyaNo>
                    <dosyaTurKod>294</dosyaTurKod>
                    <dosyaAcilisTarihi>2019-06-19 03:50:05.0</dosyaAcilisTarihi>
                    <dosyaDurumu>0</dosyaDurumu>
                    <birimTuru1>11</birimTuru1>
                    <birimTuru2>1101</birimTuru2>
                    <birimTuru3>1199</birimTuru3>
                    <dosyaId>523127202</dosyaId>
                    <dosyaKisiSize>1</dosyaKisiSize>
                    <dosyaTurAciklama>MTS Dosyası</dosyaTurAciklama>
                </AvukatDosyaKisiDVO>
            </liste>
            <liste>
                <AvukatDosyaKisiDVO>
                    <birimId>105428346</birimId>
                    <birimAdi>Merkezi Takip Sistemi</birimAdi>
                    <dosyaNo>2019/15333</dosyaNo>
                    <dosyaTurKod>294</dosyaTurKod>
                    <dosyaAcilisTarihi>2019-06-19 03:50:05.0</dosyaAcilisTarihi>
                    <dosyaDurumu>0</dosyaDurumu>
                    <birimTuru1>11</birimTuru1>
                    <birimTuru2>1101</birimTuru2>
                    <birimTuru3>1199</birimTuru3>
                    <dosyaId>523123427202</dosyaId>
                    <dosyaKisiSize>1</dosyaKisiSize>
                    <dosyaTurAciklama>MTS Dosyası</dosyaTurAciklama>
                </AvukatDosyaKisiDVO>
            </liste>
            <actualCount>0</actualCount>
            <currentPage>0</currentPage>
            <pageSize>0</pageSize>
            <cacheID>0</cacheID>
            <recordCount>0</recordCount>
        </DVOList>
    </object-array>
</object-array>

Get these with using Substring..

<dosyaId>523123427202</dosyaId>
<dosyaId>5231272023</dosyaId>

A: An xml parser is obviously the correct option, but using your code one option is to loop (code assumes there are always pairs) - e.g.
 var icrasorgula_cevap = @"<dosyaId>first</dosyaId><dosyaId>second</dosyaId><dosyaId>third</dosyaId>";

 int index = 0;
 int pTo = 0;
 while ((index = icrasorgula_cevap.IndexOf("<dosyaId>", pTo)) >= 0)
 {
   int pFrom = index + "<dosyaId>".Length;
   pTo = icrasorgula_cevap.IndexOf("</dosyaId>", pFrom);

   string result = icrasorgula_cevap.Substring(pFrom, pTo - pFrom);
   Console.WriteLine(result); // first, second, third

   }

redpajama_set_name: RedPajamaStackExchange


Did you know there are lots of expressions in English that contain the word "French"?
Here are our top ten, and you may be surprised to find out that some of them are not even French! Take a look at these expressions; you might be even more surprised by their translations.
Même pas French! They are from Belgium as everyone knows. The date of the first use of the word "French" is not very clear.
Some people believe that the term "French" was introduced when British and American soldiers arrived in Belgium during World War I and consequently tasted Belgian fries.
They supposedly called them "French", as it was the local language and the official language of the Belgian Army at that time, believing themselves to be in France.
French Toast is older than you might think, going all the way back to Medieval times, long before France was even founded, but one popular legend states that the "French" in the name doesn't refer to the nation, rather to an innkeeper named Joseph French, who was American. How ironic!
The French call it "pain perdu", which literally means lost bread, as it is made with stale bread.
The French knicker style evolved from drawers, the baggy long-legged underwear of the Victorian era, and they may have derived their name from the frilly underwear worn by Parisienne Can-Can dancers from the late 1800s to the early 1900s.
During the wars of the 16th century, the French returned home with some borrowed ideas on art and architecture. Nature, light and symmetry reminiscent of Roman culture, were taken and translated into French culture.
A view into the flower garden was now a work of art. The French called them "porte-fenêtres", which literally means door-windows, it does make sense!
Ah! La fameuse baguette française! In England, a baguette is a piece of split French stick stuffed with some yummy food; in France, this is called 'un sandwich' – an English word!
The French maid refers to a strongly modified style of servants' dress that evolved from the typical housemaid's black and white afternoon uniform of 19th century France, and its later use by stereotypical soubrette characters in burlesque dramas and bedroom farces.
Ever wondered why French beans are called French beans? We all did at VoulezVouloz, so we decided to find out.
It ended up being a very interesting and stormy debate, but without much success. So, just for your information, French beans, also called haricots verts, are a variety of green beans that are longer, thinner, crisper, and more tender than "standard" green beans.
The phrase may have its roots in American history during the French and Indian wars. Approximately 140 French soldiers were captured near Lake George in New York and ferried to an island in the lake. The French, knowing the area better than the British, waited until near dawn and quietly waded ashore leaving their captors bewildered on arising.
In French, they say "filer à l'anglaise", which means "to leave English style". These languages also say, "to leave English style": Czech, Hungarian, Italian, Polish, Russian and Walloon. On the other hand, German, Portuguese and Spanish will say, "to leave French style".
Obviously, this just a shortlist of our favourite 'French' expressions. We could also mention the 'French poodle', 'French braid', 'French cleaners' and so many more. Even the 'French letter'!
Can you name some others in the comments below?


DRILLMEC is an international leader in design, manufacture and distribution of drilling and workover packages for offshore and onshore applications as well as a wide range of drilling equipment. DRILLMEC is part of the TREVI Group, a multinational organization with more than fifty years of activity in the drilling business. DRILLMEC is able to offer a complete range of products and engineering support to cover all different application and market needs.
During 2012 and 2013 Drillmec has been awarded a total amount of approximately $250 million contract to supply four offshore drilling and work over packages. The offshore market is developing at an incredibly fast pace, and Drillmec is strengthening its presence with confidence, ready to establish itself in this challenging and attractive market. Two of those packages are 3000 HP offshore modules rigs to Perforadora Mexico. The third one is a 2000 HP complete drilling package for the development of Filanovsky oilfield in the Russian Caspian Sea.
While the latest one is a new compact unit hydraulic driven for Intervention & Completion Unit for dual simultaneous operation with main drilling package for operations in the North Sea. For the North Sea Project in particular Drillmec scope of supply includes a tailor made HH220 FA multipurpose rig suitable to cover all drilling and work over activities in an offshore oilfield service. The rig will be designed to ensure high safety standards, reliability and efficient operation rates to ensure low maintenance costs and long operating life. This tailor made HH220 package will meet all Statoil and North Sea requirements which are the higher ones in the world in terms of quality and safety standards.
All these contracts are an extremely important step for Drillmec's ambition to become one of the main players in the offshore market, since all rig packages have been designed and are being manufactured entirely by Drillmec. All clients have chosen DRILLMEC for its solid background in the offshore industry, the high level of technology of its products together with competitive prices, reliable delivery time and 24/7 after sales assistance.
The 2013 edition of the OTC (Offshore Technology Conference) in May was the perfect opportunity for Drillmec to show the newly designed package to potential customers and explain the innovative aspects and main advantages of the product. Those new platform rigs intend to respond to all different needs of different offshore markets.
More in general regarding the specific modular rigs market, the offshore industry around the world is looking for various ways to improve the installation of the offshore drilling packages. Given the recent increased emphasis on permits, certifications and safety, often extremely time consuming, especially in the Gulf of Mexico, after the Macondo incident, it is more crucial than ever that the offshore platform gets installed in the quickest and safest way possible.
On top of the elements just described, offshore rigs have to rely on traditional derrick barge cranes that are often times not readily available to lift these drilling units onto the platforms. With this in mind, Drillmec developed its Offshore Modules Platform Drilling Rigs, which do not need to be equipped with these derrick barge cranes, in order to win this challenge.
These rigs are designed and built in modules so that the modules can be installed by the drilling rigs' operational cranes, with the help of one set of temporary cranes. The high number of light modules in Drillmec's Offshore Modules Platform simplifies the installation process, giving also the advantage of an even weight distribution on the platform deck.
This is only the beginning of an offshore market that will diversify and expand, while giving a careful look to regulations, liability costs and time management.
For all the ongoing project Drillmec has found an innovative solution to simplify the installation process and cut the costs, after carefully studying the market's feedback and requirements. Once again Drillmec has been able to come up with solid and unique designs to meet the needs of its customers.


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Eupedia Home > England Travel Guide > Kent > Knole House Eupedia Rating:
Built in 1456 by Thomas Bouchier, Archbishop of Canterbury, Knole House is one of the great treasure houses of England, as well as one of the most visited site owned by the National Trust.
The history of the estate goes back to the 12th century. It was the residence of five archbishop of Canterbury in total, before being confiscated by Henry VIII.
In 1566, Knole House was given by Elizabeth I to her cousin and favourite, Thomas Sackville, 1st Earl of Dorset, whose descendants still own it today. Sackville enlarged and embellished the house, which remains little altered since then.
Nowadays, Knole's prime attraction is the wonderful 17th-century royal Stuart furniture collection, unrivalled in England by its rarity and quality. The house has a stupendous amount of Renaissance, Tudor and Stuart artworks, including first-class plasterwork ceilings, grand tapestries, carved marble, silver furniture, painted walls, as well as portraits by Van Dyck, Gainsborough and Reynolds.
Knole House is so extensive that is resembles a village of terraced Renaissance houses separated by a central Gatehouse, rather than a single habitation. There are no less than 365 rooms, 52 stairs and 7 courtyards. You can also watch deer grazing in the surrounding park.
The manor and Sackville family appear in some literary works, such as V. Sackville-West's work 'Knole and the Sackvilles', and Virginia Woolf's 'Orlando'.
Knole House is open from Wednesday to Sunday, 11am to 4pm, between 27 March and 31 October. Admission is £6 for adults and £3 for children. Access to the garden only is £2.
Knole House is located in Sevenoaks, 35min by train from London's Charring Cross station (£7.10). The house is 2.5km from the train station.