text:
package com.amazonaws.services.sns.model;

import java.io.Serializable;
import javax.annotation.Generated;

import com.amazonaws.AmazonWebServiceRequest;

/**
 *

 * Input for RemovePermission action.
 *

 *
 * @see AWS API
 *      Documentation
 */
@Generated("com.amazonaws:aws-java-sdk-code-generator")
public class RemovePermissionRequest extends com.amazonaws.AmazonWebServiceRequest implements Serializable, Cloneable {

    /**
     *

     * The ARN of the topic whose access control policy you wish to modify.
     *

     */
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    /**
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     * The unique label of the statement you want to remove.
     *

     */
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     *        The ARN of the topic whose access control policy you wish to modify.
     * @param label
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    /**
     *

     * The ARN of the topic whose access control policy you wish to modify.
     *

     *
     * @param topicArn
     *        The ARN of the topic whose access control policy you wish to modify.
     */

    public void setTopicArn(String topicArn) {
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    /**
     *

     * The ARN of the topic whose access control policy you wish to modify.
     *

     *
     * @return The ARN of the topic whose access control policy you wish to modify.
     */

    public String getTopicArn() {
        return this.topicArn;
    }

    /**
     *

     * The ARN of the topic whose access control policy you wish to modify.
     *

     *
     * @param topicArn
     *        The ARN of the topic whose access control policy you wish to modify.
     * @return Returns a reference to this object so that method calls can be chained together.
     */

    public RemovePermissionRequest withTopicArn(String topicArn) {
        setTopicArn(topicArn);
        return this;
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    /**
     *

     * The unique label of the statement you want to remove.
     *

     *
     * @param label
     *        The unique label of the statement you want to remove.
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    /**
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     * The unique label of the statement you want to remove.
     *

     *
     * @return The unique label of the statement you want to remove.
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    /**
     *

     * The unique label of the statement you want to remove.
     *

     *
     * @param label
     *        The unique label of the statement you want to remove.
     * @return Returns a reference to this object so that method calls can be chained together.
     */

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     * @see java.lang.Object#toString()
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    @Override
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redpajama_set_name: RedPajamaGithub


text:
Home /NEWS/Cadbury Bournvita Rolls Out #GetTheMessage Campaign; Extends Support to Help Parents with Children's Mental Well-being
Cadbury Bournvita Rolls Out #GetTheMessage Campaign; Extends Support to Help Parents with Children's Mental Well-being
As a brand that places progressive parenting at its core, Cadbury Bournvita, India's favourite malted food drink and a legacy nutrition brand has rolled out 'Get The Message', a digital first campaign aimed at raising awareness around kids' mental and emotional well-being and partner with parents in this journey. The campaign was conceptualized and brought to life in partnership with Ogilvy India and mental health organization, The MINDS Foundation.
Speaking about the campaign, Inderpreet Singh, Associate Director – Marketing (Beverages, Meals, Candies & Gums), Mondelez India, said, "The pandemic and the subsequent lockdown brought forth a new parenting challenge. The physical restrictions of social isolation, schools being shut, being constantly cooped up at home has impacted children mentally. The signs of children struggling with their mental and emotional health are often very subtle and sometimes not picked up or tend to be misread by parents. As a trusted brand that has always highlighted the need for progressive and holistic parenting, #GetTheMessage campaign is an attempt to help parents identify these signs and provide them with the right resources to ensure their children's mental and emotional wellbeing. The idea leverages technology in a smart way to provide resources to parents and break the taboo around this topic."
Along with the digital films, Cadbury Bournvita and Ogilvy India teams creatively partnered to get the audience engaged through an AI powered chat BOT. Using this innovative disruption, the campaign delivers content customized to the viewer's awareness levels on the topic. The #GetTheMessage campaign starts with two films that segue seamlessly into a personalized bot-based interaction with each viewer. In addition, the campaign lends itself with a dedicated website www.mannkitayyari.in and a 24/7 toll-free helpline to not only help parents focus on their children's mental wellbeing, but also provides them with resources to sensitively handle the growing mental and emotional challenges that children face these days. To ensure this, Cadbury Bournvita has partnered with MINDS foundation, an NGO founded in 2010 on a mission to create a world that fosters a shared approach to mental wellness — in which anyone, anywhere can access the resources they deserve.
Speaking about this association Dr. Raghu Appasani, CEO, MINDS foundation, said, "Mental health is something we all have and therefore it is important to be able to understand it in oneself and in others. Through this incredible partnership with Cadbury Bournvita, we have been able to curate our years of evidence-backed mental health research and expertise into easy to understand, interactive and accessible resources for parents and make it available across the country. As you explore the chatbot and the website, you will come across educational materials on how to engage with children struggling with their mental health, have difficult conversations, equip them with tools for resilience, and develop stronger relationships. Additionally, we have been able to provide access to a toll-free 24/7 helpline for parents to reach out. This is just the beginning of our partnership with Cadbury Bournvita and we are very excited to continue our journey and mission to provide further resources."
Akshay Seth, Group Creative Director & Chinmay Raut, Senior Creative Director, Ogilvy India, said, "The signs of mental health struggles are there for one to see as well as miss. We wanted to mirror this reality in a very organic way through the films by showing the point of view of both, the parent, and the child. For parents the sign can be easy to miss but children seek a shoulder, and we wanted the audience to be that shoulder. By getting the viewer to have a conversation with the affected kid on WhatsApp via a bot, we are breaking the wall and making the viewer understand the condition a little better. We are also empowering parents to reach out for further help via counsellors so that MannKiTayyari no longer gets overlooked."
The campaign will also be amplified through influencer engagement, online webinars, partnerships with leading online platforms along with on-pack integration to drive awareness amongst parents.
upGrad to add 30 + Top Global Universities in next 12 months
The Shri Ram Wonder Years, Rohini hosts donation drive on the auspicious occasion of Navratri

redpajama_set_name: RedPajamaCommonCrawl


text:
Criteria for the use of omics-based predictors in clinical trials
Cross-Platform Omics Prediction procedure: a statistical machine learning framework for wider implementation of precision medicine
Kevin Y. X. Wang, Gulietta M. Pupo, … Jean Y. H. Yang
Stargazing through the lens of AI in clinical oncology
Constance D. Lehman & Shandong Wu
Big data in basic and translational cancer research
Peng Jiang, Sanju Sinha, … Eytan Ruppin
Envisioning the future of precision oncology trials
Subha Madhavan, Robert A. Beckman, … Paul Macklin
Evaluating eligibility criteria of oncology trials using real-world data and AI
Ruishan Liu, Shemra Rizzo, … James Zou
Identifying gene expression patterns associated with drug-specific survival in cancer patients
Bridget Neary, Jie Zhou & Peng Qiu
Digital Display Precision Predictor: the prototype of a global biomarker model to guide treatments with targeted therapy and predict progression-free survival
Vladimir Lazar, Shai Magidi, … Richard L. Schilsky
Gene expression based inference of cancer drug sensitivity
Smriti Chawla, Anja Rockstroh, … Debarka Sengupta
Multi-omic machine learning predictor of breast cancer therapy response
Stephen-John Sammut, Mireia Crispin-Ortuzar, … Carlos Caldas
Lisa M. McShane1,
Margaret M. Cavenagh1,
Tracy G. Lively1,
David A. Eberhard2,
William L. Bigbee3,
P. Mickey Williams4,
Jill P. Mesirov5,
Mei-Yin C. Polley1,
Kelly Y. Kim1,
James V. Tricoli1,
Jeremy M. G. Taylor6,
Deborah J. Shuman1,
Richard M. Simon1,
James H. Doroshow1 &
Barbara A. Conley1
Predictive markers
The US National Cancer Institute (NCI), in collaboration with scientists representing multiple areas of expertise relevant to 'omics'-based test development, has developed a checklist of criteria that can be used to determine the readiness of omics-based tests for guiding patient care in clinical trials. The checklist criteria cover issues relating to specimens, assays, mathematical modelling, clinical trial design, and ethical, legal and regulatory aspects. Funding bodies and journals are encouraged to consider the checklist, which they may find useful for assessing study quality and evidence strength. The checklist will be used to evaluate proposals for NCI-sponsored clinical trials in which omics tests will be used to guide therapy.
High-throughput 'omics' technologies hold great promise to provide detailed characterization of diseases to more effectively predict a patient's clinical course or to select the most beneficial therapies (see Box 1). These technologies have been embraced enthusiastically in oncology, as the heterogeneous character of malignant diseases presents substantial challenges for cancer detection, prognosis and optimal selection of therapy. Many preclinical studies using these technologies to elucidate biological features and mechanisms have been published, and retrospective studies applying omics assays to stored human biospecimens have been conducted to develop mathematical models to predict clinical endpoints such as survival or response to therapy.
Despite numerous publications, however, few omics-based predictors have been translated successfully into clinically useful tests. A factor that contributes to the slow pace of clinical translation is the challenge of assessing whether the body of evidence for an omics-based test is sufficiently comprehensive and reliable that the test is ready for definitive evaluation in a clinical trial in which it could be used to direct patient care. Translation from research-grade omics assays to clinical-grade omics-based tests1 requires a rigorous development and validation process with attention to the complexities of omics assays and their application to clinical specimens, specialized expertise required to appropriately develop and evaluate mathematical predictor models built from high-dimensional data, and multiple ethical, legal and regulatory issues.
Recently there have been some widely publicized cases of premature advancement of omics-based tests to use in trials in which they were used to guide patient treatment decisions. These cases led to calls for examination of the field of translational omics. The Institute of Medicine (IOM) conducted a study1 to review the field and formed the Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials. The group's task statement included recommending an evaluation process for determining when omics tests are fit for use in clinical trials and applying it to several specific cases of premature use of omics-based tests1. The resulting report laid out a three-phase process for the development and evaluation of omics-based tests for use in clinical trials: the discovery phase, the test validation phase, and the evaluation for clinical utility and use stage.
During the IOM committee deliberations, the NCI convened a workshop to bring together scientists and stakeholders who had an interest in this area of research to stimulate community dialogue. Subsequently, a working group was formed to develop a checklist that would operationalize the principles set forth in the IOM report and the NCI workshop discussions.
The results of those efforts are presented in Table 1, which lists 30 criteria that should be addressed to determine the readiness of an omics test for use in a prospective clinical trial. These criteria apply to any clinical trial involving the investigational use of an omics test that will influence the clinical management of patients in the trial; for example, the selection of therapy. These criteria cover not only the strength of evidence in support of an omics test but also the practical issues that must be considered before the test is used in a clinical setting. The criteria can also be helpful in assessing the reliability and credibility of an omics predictor to justify its use on valuable non-renewable archived specimens collected from patients who were prospectively enrolled in previous clinical studies. This paper presents the criteria in checklist form with brief background. Readers are referred to a recently published companion paper2 for a more complete explanation and elaboration of the rationale for each criterion.
Table 1 Criteria for the use of omics-based predictors in NCI-supported clinical trials
Box 1: Definition of 'omics'
In its report, Evolution of Translational Omics: Lessons Learned and the Path Forward, the Institute of Medicine Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials defines 'omics' as the study of related sets of biological molecules in a comprehensive fashion. Examples of omics disciplines include genomics, transcriptomics, proteomics, metabolomics and epigenomics. An omics-based test is defined as "an assay composed of or derived from multiple molecular measurements and interpreted by a fully specified computational model to produce a clinically actionable result"1.
Specimen issues
Molecular profiles generated by the use of omics technologies can be sensitive to specimen collection, processing and storage conditions3. Investigators should consider the conditions under which specimens used in developmental studies were collected and handled to assess the robustness of an omics test to various specimen conditions. It may be necessary to conduct additional feasibility studies to document that the omics test will perform satisfactorily under the range of conditions in which the specimens will be obtained and stored in typical clinical settings; alternatively, more restrictive requirements for specimen collection, processing and storage should be clearly specified before the test is used in a clinical trial or other clinical validation study.
Criteria for specimen quality, amount (mass or volume), and composition should be clearly specified in order to qualify a specimen or its isolated analytes as suitable for assay by the omics test. Appropriate criteria will depend on the specimen type and the particular omics assay platform to be used. Details of the specification might include per cent purity of the target cells or intact analyte of interest and specific mass or volume of the specimen or analytes isolated from the specimen. It should be established that it is feasible to achieve these criteria in clinical settings.
Assay issues
Variations in assay procedures due to differences in technical protocols, reagents, and scoring and reporting methods can have a substantial impact on the analytical performance of an omics assay and its comparability among laboratories4,5. Many omics tests are developed using data from retrospective studies in which these aspects of the assay were not standardized. This can lead to uncertainties in how the test will perform when based on assay data from a new laboratory, including the laboratory or laboratories that will generate the assay data for a prospective trial. It is important to develop detailed standard operating procedures (SOPs) for the assay underlying the omics test and to establish that studies conducted previously to clinically validate the omics test were based on data expected to be comparable to new data generated under the specified SOPs.
Analytical performance of the omics assay under the proposed SOPs must be documented and found to be acceptable in terms of metrics such as accuracy, precision, coefficient of variation, sensitivity, specificity, linear range, limit of detection, and limit of quantification, as applicable. Calibrators, analytical standards, and controls are essential components of the SOPs and should be described clearly. Quality assurance procedures should include criteria for acceptance or rejection of assay batches and results from individual specimens. When multiple technicians or laboratories will conduct the assays, monitoring procedures should be in place to ensure comparability across technicians and laboratories. Methods for assay scoring and reporting should be clearly specified. Turnaround times for return of test results should be within acceptable limits that will be dependent on the particular clinical situation and should be sufficiently rapid to not impede clinical management timelines. Feasibility studies to assess assay analytical performance, reproducibility and turnaround times may be required in advance of initiating a clinical trial to firmly establish the suitability of the omics test for use in a real-time clinical setting.
Model development and evaluation
Many omics tests are developed using existing omics, clinical and pathology data or using data generated from retrospective specimen collections. These data may be incomplete or unreliable and should be examined for errors, inconsistencies or bias. Omics assays can be sensitive to a variety of ancillary technical influences that result in artefacts in the generated data. Of particular concern is the potential for such artefacts to be confounded with clinical variables or endpoints. Efforts should be made to identify potential confounders, including source of specimens (for example, clinical sites processing specimens differently), laboratory performing the omics assay, and assay batches6.
Examples of flawed applications of statistical approaches for development of omics predictors and for evaluation of their performance are abundant in the literature7,8,9. Model overfitting, which occurs when a statistical model describes random noise instead of capturing the true association between predictor variables and a clinical endpoint, is a common problem in omics research projects, in which the number of analytes measured per specimen exceeds the number of specimens studied. Overfitting can be reduced by the use of model 'regularization' approaches that constrain the complexity of the model, but these approaches do not completely eliminate overfitting risk. It is common for researchers without the appropriate expertise to misunderstand and misapply modelling techniques. In addition, if flawed methods for model performance assessment are used, then overfitting may escape detection. A common mistake is failure to maintain strict separation between data used to build a model ('training set') and data used to assess model performance ('testing set'). Numerous published papers have inappropriately reported model performance estimates based on resubstitution of data used to build a model back into that same model. These so-called 'resubstitution estimates' are severely (optimistically) biased. Assessment of model performance on the combined training and testing data sets is similarly problematic. Re-use of training data is acceptable only if performed properly using data resampling methods10 that iteratively split the training data to hold out subsets of the data that are not used for model building and can therefore be used to check model performance.
Development of an omics predictor can be an iterative process involving several adjustments to improve performance. With regard to the three phases of the development and evaluation process in the IOM report1 on omics tests, it is noted in the report that preliminary validations may occur in the test validation phase, and the definitive evaluation of clinical utility takes place in the final phase. It is important to be able to discern the point at which the omics test is 'locked down', or finalized, in all aspects, including specimen requirements, technical protocol for assay, data preprocessing, the form of mathematical predictor model, and interpretation of the test result. The test is then ready to enter the final evaluation for clinical utility and use stage, at which there are three basic options for clinical utility evaluation: first, a prospective evaluation of the omics test on a retrospective specimen collection from a clinical trial or prospective cohort study; second, a prospective clinical trial in which the test does not direct patient management; and third, a prospective clinical trial in which the omics test is used to direct patient management. Ideally, there should have been a blinded and rigorous preliminary validation of performance of the locked-down model on an external independent specimen set during the test validation phase. If an independent external validation set is not possible because adequate specimen collections do not exist, then existing performance evaluations based on internal validations should be carefully reviewed to ensure that they were rigorous and used appropriate methods. In this situation, it may be necessary to use a clinical trial design that does not allow the test to influence patient care.
When further adjustments are made to the omics test or data after the final validation data have been unblinded, there is a risk of compromising the validation. If the omics test is adjusted, either a new validation must be performed or additional evidence must be obtained; for example, by conducting an assay-bridging study to ensure that the adjustments to the test have not adversely affected its performance.
Investigators should be prepared to supply data and computer code as part of the review process for proposals to use omics tests in clinical trials. It is highly recommended that investigators follow reproducible research practices so that they will be able to supply the needed information quickly and easily for verification of the validation of the test and its locked-down form. Readers are referred to the companion publication2 for further discussion of recommended reproducible research practices.
Clinical trial design
A clinical trial for definitive evaluation of an omics test should be conducted using the same rigorous standards expected for clinical trials evaluating experimental therapies. In some circumstances, high-level evidence can be obtained by use of specimens from an already-completed clinical trial11. Accepted standards for good clinical practice must be followed12,13, including development of a formal protocol with clearly stated objectives and eligibility criteria, an informatics plan for management of clinical and omics data, a pre-specified study design14 and statistical analysis plan, complete specification of the omics test, and justification for equipoise for any treatment randomizations (if the trial is conducted prospectively). The study team must include individuals with appropriate expertise to assume responsibility for the clinical, laboratory, pathology, bioinformatics, data management and statistical aspects of the study.
Ethical, legal and regulatory issues
Numerous ethical, legal and regulatory issues must be addressed in the course of developing an omics test for clinical use. Research involving human subjects, which includes retrospective use of specimens from living subjects, requires that adequate protection is in place to ensure the safety of patients and the privacy and confidentiality of patient information15. Ensuring appropriate protections has become more challenging as omics technologies make it possible to provide detailed genetic characterizations of individuals and much research data are made publicly available. Informed consent documents for a clinical trial using an omics test to guide patient management must accurately describe any potential risks from participation in a study and all potential conflicts of interest on the part of study investigators or sponsoring institutions. Laboratory tests must be conducted in environments that meet Clinical Laboratory Improvement Amendments certification requirements if the results will be reported to the patient or the patient's physician16. Responsible parties at participating institutions (for example, institutional review boards, protocol review committees), trial sponsors (for example, the NCI, universities, companies), and the US Food and Drug Administration (FDA) (for example, for Investigational Device Exemption (IDE)17 or Investigational New Drug18 applications) must be fully informed of study details and approve the study before it proceeds.
If the omics assay to be used in a clinical trial could be considered a significant-risk assay, including—but not limited to—one used to choose among treatments, investigators must consult with the FDA to determine whether an IDE from the Center for Devices and Radiologic Health, or a similar evaluation carried out through the Investigational New Drug process, is required. The complexities of omics-based tests, together with the FDA's evolving view of regulatory enforcement discretion for these tests, make it important to have early communications with the FDA. Investigators may find it helpful to discuss the trial formally with the FDA in a pre-submission process if they are not familiar with IDE requirements19.
Intellectual property issues may apply to the use of the specimens, biomarkers, assays, and computer software used for calculation of the predictor. Intellectual property rights should be documented and respected by all parties involved. Potential conflicts of interest of study investigators must be disclosed and managed.
Evaluation of the readiness of an omics test to be used for clinical care requires careful consideration of the body of evidence supporting the test's analytical and clinical validity and potential clinical utility, as well as an understanding of ethical, legal and regulatory issues. Funding bodies and journals are encouraged to consider using the checklist as an evaluation guide in their review processes. The NCI plans to use the checklist presented here to evaluate proposals for the use of omics tests in clinical trials where the test will be used to guide patient care. Although it is not expected that exploratory studies using omics assays or studies aiming to develop omics tests will meet all of the checklist criteria, the checklist does provide a convenient framework by which to assess the stage of development of an omics test and the strength and quality of the accumulated evidence. Several of the checklist criteria (those that are not specific to the development of models from high-dimensional data) also apply to studies of single biomarkers, or limited panels of biomarkers, measured by a variety of conventional assay methods. The checklist may, therefore, serve as a useful reference in a variety of review settings.
It is hoped that this 30-point checklist will guide investigators towards the use of best practices in omics test development, help them to more reliably evaluate the quality of evidence in support of omics tests, and assist them in planning appropriately for the clinical use of omics predictors. The ultimate goal is to develop a more efficient, reliable and transparent process to move omics assays from promising research results to clinically useful tests that improve patient care and outcome.
The print version inadvertently lacked final corrections to affiliation 5 and Table 1; however, the online PDF and HTML versions are correct.
Institute of Medicine. Evolution of Translational Omics: Lessons Learned and the Path Forward (eds Micheel, C. M., Nass, S. & Omenn, G. S. ) (The National Academies Press, 2012)A report produced by a committee formed in response to an NCI request for recommendations to strengthen omics-based test development and evaluation; this identifies best practices to enhance the development, evaluation and translation of omics-based tests while reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
McShane, L. M. et al. Criteria for the use of omics-based predictors in clinical trials: explanation & elaboration. BMC Med.11, 220 (2013)This paper is an annotated companion to the short version of the guidelines presented here, elucidating the rationale underlying the development of the criteria in greater detail.
Moore, H. M. et al. Biospecimen Reporting for Improved Study Quality (BRISQ). Cancer Cytopath.119, 92–101 (2011)
Dobbin, K. K. et al. Interlaboratory comparability study of cancer gene expression analysis using oligonucleotide microarrays. Clin. Cancer Res.11, 565–572 (2005)
Shi, L. et al. The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements.Nature Biotechnol.24, 1151–1161 (2006)
Leek, J. T. et al. Tackling the widespread and critical impact of batch effects in high-throughput data. Nature Rev. Genet.11, 733–739 (2010)
Dupuy, A. & Simon, R. M. Critical review of published microarray studies for cancer outcome and guidelines on statistical analysis and reporting. J. Natl. Cancer Inst.99, 147–157 (2007)
Simon, R., Radmacher, M. D., Dobbin, K. & McShane, L. M. Pitfalls in the use of DNA microarray data for diagnostic and prognostic classification. J. Natl. Cancer Inst.95, 14–18 (2003)
Subramanian, J. & Simon, R. Gene expression-based prognostic signatures in lung cancer: ready for clinical use? J. Natl. Cancer Inst.102, 464–474 (2010)
Molinaro, A. M., Simon, R. & Pfeiffer, R. M. Prediction error estimation: a comparison of resampling methods. Bioinformatics21, 3301–3307 (2005)
Simon, R. M., Paik, S. & Hayes, D. F. Use of archived specimens in evaluation of prognostic and predictive biomarkers. J. Natl. Cancer Inst.101, 1446–1452 (2009)
ICH Expert Working Group. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use; http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Quality/Q2_R1/Step4/Q2_R1__Guideline.pdf (accessed, 19 February 2013)
US Food and Drug Administration. Guidance for Industry: Computerized Systems Used in Clinical Investigations (US Department of Health and Human Services, 2007)
Freidlin, B., McShane, L. M. & Korn, E. L. Randomized clinical trials with biomarkers: design issues. J. Natl. Cancer Inst.102, 152–160 (2010)
US Department of Health & Human Services. SACHRP Letter to the Secretary: FAQs, Terms and Recommendations on Informed Consent and Research Use of Biospecimens; http://www.hhs.gov/ohrp/sachrp/20110124attachmentatosecletter.html (accessed, 19 February 2013)
Center for Medicare and Medicaid Services. Clinical Laboratory Improvement Amendments (CLIA); http://www.cms.gov/Regulations-and-Guidance/Legislation/CLIA/index.html?redirect = /CLIA (accessed, 19 February 2013)
US Food and Drug Administration. Device Advice: Comprehensive Regulatory Assistance; http://www.fda.gov/MedicalDevices/DeviceRegulationandGuidance/default.htm. (accessed, 19 February 2013)
US Food and Drug Administration. Investigational New Drug (IND) Application; http://www.fda.gov/Drugs/DevelopmentApprovalProcess/HowDrugsareDevelopedandApproved/ApprovalApplications/InvestigationalNewDrugINDApplication/default.htm (accessed, 19 February 2013)
US Food and Drug Administration. Draft Guidance for Industry and FDA Staff: Medical Devices: the Pre-submission Program and Meetings with FDA Staff (US Department of Health & Human Services); http://www.fda.gov/MedicalDevices/DeviceRegulationandGuidance/GuidanceDocuments/ucm310375.htm (accessed, 19 February 2013)
Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, 20892, Maryland, USA
Lisa M. McShane, Margaret M. Cavenagh, Tracy G. Lively, Mei-Yin C. Polley, Kelly Y. Kim, James V. Tricoli, Deborah J. Shuman, Richard M. Simon, James H. Doroshow & Barbara A. Conley
Department of Pathology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 27599, North Carolina, USA
David A. Eberhard
Department of Pathology and University of Pittsburgh Cancer Institute, Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, 15213, Pennsylvania, USA
William L. Bigbee
Frederick National Laboratory for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, 21702, Maryland, USA
P. Mickey Williams
Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, 02142, Massachusetts, USA
Jill P. Mesirov
Department of Biostatistics, University of Michigan, Ann Arbor, 48109, Michigan, USA
Jeremy M. G. Taylor
Lisa M. McShane
Margaret M. Cavenagh
Tracy G. Lively
Mei-Yin C. Polley
Kelly Y. Kim
James V. Tricoli
Deborah J. Shuman
Richard M. Simon
James H. Doroshow
Barbara A. Conley
B.A.C. and L.M.M. conceived the idea for this paper and the checklist. The initial draft of the manuscript was the joint effort of several authors contributing according to their particular areas of expertise (W.L.B., M.M.C., B.A.C., D.A.E., T.G.L. and L.M.M.). All authors provided comments, suggested edits, and contributed additional expertise to enhance the initial draft and produce the final version of the manuscript.
Correspondence to Lisa M. McShane.
This work is licensed under a Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported licence. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-sa/3.0/.
McShane, L., Cavenagh, M., Lively, T. et al. Criteria for the use of omics-based predictors in clinical trials. Nature 502, 317–320 (2013). https://doi.org/10.1038/nature12564
Heterogeneity of triple negative breast cancer: Current advances in subtyping and treatment implications
Karama Asleh
Nazia Riaz
Torsten O. Nielsen
Journal of Experimental & Clinical Cancer Research (2022)
Knowledge gaps in late-onset neonatal sepsis in preterm neonates: a roadmap for future research
Serife Kurul
Kinga Fiebig
H. Rob Taal
Pediatric Research (2022)
A guide to systems-level immunomics
Lorenzo Bonaguro
Jonas Schulte-Schrepping
Joachim L. Schultze
Nature Immunology (2022)
Challenges in translational machine learning
Artuur Couckuyt
Ruth Seurinck
Yvan Saeys
Development and validation of genomic predictors of radiation sensitivity using preclinical data
Venkata S. K. Manem
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Guidelines for clinical use of omics data
The potential of high-throughput 'omics' in clinical medicine is immense, with oncology leading the way in adopting these technologies. Working with researchers and clinicians from across the spectrum of these disciplines, the US National Cancer Institute (NCI) has developed a checklist of criteria that can be used to determine the readiness of omics-based tests for guiding patient care in clinical trials. Published in this Perspective feature, the checklist focuses on best practice in specimen preparation, assays, mathematical modelling, clinical trial design, ethics and more. It will be used to evaluate proposals for NCI-sponsored clinical trials in which omics tests guide therapy.


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Indian Peaks West Lafayette CO
Mc Stain builders started sales in Indian Peaks West as early as 2001. The first section to be completed was Caribou Pass in the Meadow Mountain section of the community. The homes on Blue Lake Trail and some of the custom homes were completed in 2002. There are 328 homes in the entire community and 55 of those are custom builds. Of the 273 homes built by Mc Stain outside of the custom section there is a strong mix of styles and sizes. There are a few duplexes and many town-homes in this section. There are also smaller single-family homes as well as larger properties approaching 4000 square feet in size. Mc Stain wanted this community to be for everyone offering the various sizes to attract different types of homeowners.
The neighbors in Indian Peaks West are very connected and involved with creating a community of friends. There are five parks throughout the area that offer a central meeting area for the residents who surround it. One central park is largest and offers enough space for all the residents to meet and have parties. Some of the events held in the big park include a large family pot-luck in the beginning of summer, food trucks in the warm evenings, an Easter Egg hunt in the spring, and even a July 4th bike parade! And if that all sounded like fun you should see this place on Halloween! Basically all of the homes open their doors and have a giant community party. Some of the parents walk around with the children and someone has to stay home to man the door — which basically will stay open with a stream of children in costumes looking for treats. The parents often get 'stuck' at each house saying hello to their friends while the children do the same.
Another reason Indian Peaks West is sought after is because of its zoning for Boulder schools. While all of Lafayette is part of BVSD, the zoning is for Lafayette based schools. Indian Peaks West is the only community in Lafayette receives the benefit of being enrolled into Boulder schools. This means Douglass Elementary, which is one of the top 10 schools in the state. The neighborhood also goes to Platt Middle School, which makes the top 5 ranking.
Neighborhoods in Indian Peaks West
The Indian Peaks West community in Lafayette CO has long and winding roads that lead to various sections of the community. The back section is called Thunder Lake. This is a great area because of its seclusion and large circular drive. It lends itself to children playing sports out front and learning to ride their bikes in the circle. Just a bit further to the front from Thunder Lake, and also located on a circle, is the Red Deer Trail. There is a wide open green space in the middle of the circle where children often play ball with their family. This area also has an alley which is accessed by the homes facing the Indian Peaks Trail W. These allies are found throughout certain areas of Indian Peaks West and are often called the 'Kids Super-highways.'
As you continue to approach the front of the neighborhood from Red Deer there are a few homes in Indian Peaks West itself that have a sort of alley in the front of their house. Many of the homes on Red Deer Trail back to the golf course have magnificent views! The use is intended for the homes on the street exclusively so again, it becomes a popular area for the neighbors to hang outside and talk while the children conduct their games.
The next section as you head out of the community has the custom homes on the east next to the large community park and then 'The Parks' section to the west, as it was termed by Mc Stain in construction. Many of the custom homes back to the golf course and have magnificent views. The homes in The Parks are varied from very small at 2000 square feet to larger around 4200 square feet. Some of the larger homes back to open space and have wide open green views that have natural grasses and wildlife. The smaller ones were planned my Mc Stain to have central access points thereby maximizing the lot for each home by minimizing the amount of land used for sidewalks.
There are a few sections that have 6 homes per access point, so we call them 'The 6 Packs'. These are often accessed by another one of the 'Kid Super-Highway' allies in the back. This section of the community access the Blue Lake Park for neighborly activities. There is a swing-set and climbing area where children are often seen playing throughout the day.
The last two sections of the community are closest to Baseline. They are Meadow Mountain and the homes along Indian Peaks Trail West. The Meadow Mountain community is like its own giant cul-de-sac or circle. The road is very private and only the residents of this area commonly drive through making it a great place for kids to play. There is a large central park for the residents of Meadow Mountain who enjoy a swing set and other amenities. The homes along the front of Indian Peaks Trail West range from larger single-family homes to the section of attached homes. The larger homes can approach 4,500 square feet with incredible views of the golf course from their front yards. The townhomes are tucked behind these larger properties and also have their own cul-de-sacs for the children to enjoy traffic free playing.
Indian Peaks West Real Estate Market and Listing
Photos of Indian Peaks West
Builder and Google Map
Contact TrailRidge Realty
Indian Peaks Tie-Dye Party
Click to look at the pictures from the Indian Peaks Tie-Dye Party. You will also see who won the fundraising contest.
Pictures of Indian Peaks West
Indian Peaks West Golf Course
Indian Peaks Holiday Decorations
Click to take a tour of the holiday lights displayed in the Lafayette neighborhood of Indian Peaks…
Builder and Google Maps of Indian Peaks West
The Indian Peaks Neighborhood
Indian Peaks Neighborhood Lafayette CO
The Indian Peaks Neighborhood of Lafayette CO is known for being one of the exclusive communities to live in throughout Boulder County. Click to read more.
Indian Peaks East
The East Side wraps the largest area around the golf course offering expansive snow-capped views to many homes. Click to read more about Indian Peaks East.
Indian Peaks South
Indian Peaks South has it all: great community, walkability, and a POOL! Click to read more.
Indian Peaks West
Click to read about Indian Peaks West. It's known for its connected community and neighborhood events!
See the Lafayette CO community of Indian Peaks West from a drone's perspective! More information about the community here.


Company Tropicare Sunscreen is located in the city of Warriewood. The legal address of the company is Unit 46 6 Jubilee Avenue , Warriewood, NSW 2102 Australia. For more information, please call %2b61299976161. Location of our company Tropicare Sunscreen can be viewed on the map.


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Blu-ray Review: 'Ghost in the Shell' Remains a Philosophical Anime Masterpiece
Matt Marshall March 16, 2017 0 likes
Anime 'Ghost in the Shell' Still Celebrated Two Decades Later
For 22 years, Ghost in the Shell has been the gateway for many western audiences into the vast world of anime. Besides 1988's iconic Akira, it's been said to fall down the rabbit hole of anime initiated simply by the best of the best. While it may seem like a leap of faith for the uninitiated, the payoff is a richly crafted, thought-provoking exercise like no other.
Set in 2029 Japan, the world has evolved into a network of cybernetics. Some beings nearly consist of all mechanical parts minus a consciousness (or ghost). That little fragment is all that remains of one's humanity. Hence the title – Ghost in the Shell. Major Motoko Kusanagi (voiced by Atsuko Tanaka) is one of these cyborg. Alongside her security team, Section 9, she is assigned to capture a hacker known as the Puppet Master.
The elusive Puppet Master has instrumented chaos on the network. In the midst of the cyber terror, the Puppet Master has managed to hack the consciousness of garbageman, providing the Major and her partner Batou (voiced by Akio Ōtuska) with a potential clue. It just one of the mysteries director Mamoru Oshii makes his audiences for along the course of Ghost in the Shell.
Oshii's Ghost in the Shell is clearly a film before its time. The same goes for its source material, a 1991 manga series by the same name. And without this groundbreaking anime, what would sci-fi staples such as The Matrix and Avatar be inspired from? On countless occasions, Ghost in the Shell toys more with the abstract rather than force-feeding its audience with such a direct narrative. Yes, it's easy to watch Ghost in the Shell as a well-crafted mystery that fortunately doesn't overplay its guns blazing action sequences. That last statement might be selling this anime a bit short.
What Kazunori Itō's screenplay works wonders with is the anime's deeper themes. The script begins to peel back the Major particularly, as a character. Throughout the film, she finds herself conflicted with reality, identity and the divide between man and machine. While there's a "ghost" inside her, the Major undergoes a philosophical journey to determine an original human existence. Does it even matter? Do it matter that she thinks nothing of gender when stripping "naked" or wearing skintight gear? Like the overall theme of Ghost in the Shell, ambiguity is ever present. And in a frustrating sense either, but rather an enlightening one.
Ghost in the Shell doesn't exactly answer the questions its audiences are expecting in its lightning-fast 82 minute run time. But don't worry. There's only two more films, Ghost in the Shell 2: Innocence, The New Movie plus shows Stand Alone Complex and Arise to venture deeper into the world of the cybernetic network. Think of it more as a brilliant tease to a much bigger world.
For anyone who's grown up strictly on western animation doesn't know the cinematic masterpiece they're missing by not watching Ghost in the Shell. It's quite the riveting experience that puts your brain on intellectual overdrive. But isn't that the m.o. of any sci-fi gem?
This Anchor Bay release looks rather decent with its 1080p transfer. Ghost in the Shell maintains its dated feel that functions alongside its cel animation. There is a 2.0 edition out in print that does touch up on some sequences with CGI. However, purists of the anime would rather prefer the original. There still remains a level of solid detail that defines characters and backgrounds throughout the film.
Ghost in the Shell offers two audio tracks. The dubbed English DTS-HD Master Audio 5.1 track is the preferred one for audiophiles. However, if you're to truly experience the anime in its original form, the Japanese 2.0 track is the one to listen to. Regardless, dialogue remains coherent throughout. However, the car chases and shoot-outs don't receive the maximum potential. It's a sacrifice for purists to work with a traditional stereo track.
Sadly, there are no supplemental materials to go along with the film. With the live-action film due out in a few week, we might have expected some sort of promotion. However, the packaging is spectacular. Ghost in the Shell is housed in a gorgeous looking Mondo steelbook with the Major on the cover. The Mondo series have never disappointed in terms of artwork. This re-release is strictly for the die-hards of the anime.
Matt Marshall
Matt Marshall has been reviewing films since 2003, starting with "The Lord of the Rings: The Return of the King." He specializes in home media, including 4K UHD, Blu-ray as well as box office analysis. He has a B.A. in Communications/Journalism from St. John Fisher College and resides in Rochester, NY.
Game of Thrones: "Beyond the Wall" Review
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Review: 'Victoria & Abdul' Brings to Life a Fascinating, Unexpected Friendship
Blu-ray Tuesday: Oscar Contender "Captain Phillips" Sails on 4K Waters
Weekend Box Office: "Smaug" Smokes "Anchorman" Sequel
Weekend Box Office: "Riddick" Conquers Weakest Weekend of 2013 – by Matt Marshall


Install Graphical Modelling Framework (gmf) Runtime will be there as you use your personal computer. Even if you know your personal computer well because of utilizing it for a long time, such issues will still come to haunt you. If you use the internet to browse frequently, issues are more likely to happen also. That only implies that your computer knows when it is not in a good state, and it's a good thing for you. Several problems might get worse as time passes. Coming up with the ideal remedy simply by understanding the nature of the problem is the great thing to do.
Every specific Install Graphical Modelling Framework (gmf) Runtime has its very own unique causes. It could be your driver, or an application that's not compatible with the modules of your PC. Installing a new operating system is the main resort of many people as they don't desire to bother themselves about dealing with the issue themselves. Nonetheless, what individuals don't know is that fixing the problem is advantageous. In the event you like to try fixing errors, try the following problems and see if you could fix them with the tips below.
You may already have encountered this Install Graphical Modelling Framework (gmf) Runtime. This can happen in any operating system. If you have recently changed something on your software or hardware, it may be the reason behind this error. This is not solved with a simple ESC or Ctrl + Alt + Del. You can solve this by unplugging the device attached in your PC or uninstalling the most recent software as you boot it making use of the Safe Mode. Do this after restarting your computer.
Apps like Google Chrome browser take a lot of RAM during its operation. The problem known as low virtual memory results from the prolong usage of such programs or apps that exhaust the RAM space. This will not actually happen when you have huge RAM space. In order for the computer to run smoothly, you must have extra RAM memory and you could achieve that through RAM chips. This problem actually has a fast alternative fix and it's through increasing your pagefile size. You just have to go to the system settings through the control panel. After that, just look at the top left of the window and click on advanced system settings. Then you can proceed to the advanced tab and settings. Increasing the PageFile up to 2 times bigger than the RAM memory is then possible to do from there.
This Install Graphical Modelling Framework (gmf) Runtime might be caused by a missing file of a certain program that's not yet fully installed or just a missing system file. When it is about the software, just re-install it to solve the problem. Nevertheless, if it is about a missing file, then you need to go over the web and search for a downloadable file of it. You should also not expect that the first file you download will work so you should still continue searching till you find the functional one. There are times that this error is because of the attack of a virus so be sure that your anti-virus is always updated. If your anti-virus is out of date then chances are viruses can pass through it very easily. So always consider the status of your anti-virus, keep it updated to ensure it is working well.
If you know how to solve Install Graphical Modelling Framework (gmf) Runtime by yourself, you'll be saving enough some of funds. These errors are countless but whats been stated earlier are those that commonly experienced by PC users. A lot of people immediately decide to replace their computers the moment they learn that it has errors. But the best option they have to consider first is to fix the PC. That's the reason why knowing the basic solutions to such issues is essential so that next time you experience them, you already know how to eliminate them.


When the summer monsoon season comes, it often hits Scottsdale homeowners hard. And without question, one of the leading questions that many homeowners ask is what type of HVAC flood protection strategies can they take to be certain their outdoor AC unit does not become damaged when high waters arrive.
Typically, every HVAC system installed in Scottsdale is built outside; either on the side of a home or in the back yard. And with every new HVAC system, one thing needs to be done before installation: a concrete base or footer needs to be built. This is critical because it provides a stable support for the very heavy HVAC system. A great solution to reduce potential flood damage to the HVAC unit is to build a higher concrete base – perhaps a foot or two higher than normal. Standing water that flows no higher than 12" in most cases does most flood damage in Scottsdale.
First, make sure that you check with local code enforcement or covenants inside your community to ensure that you can do this.
Contact a professional HVAC company to help with the removal of the HVAC system while a professional contractor pours the new concrete slab.
Have the same HVAC Company reinstall the HVAC system on the new concrete footer once it's cured.
First, it's easier for HVAC professionals to access, maintain and repair.
Second, it's easier for excess water to drain from a lower position.
Third, it's a traditional location and most homebuilders simply do what everybody else does.
Again, making sure you follow local code and community guidelines, first consider moving your HVAC unit to higher ground. Perhaps moving the unit to a second floor balcony or attic space that can completely protect the system from flood damage. This might be a bit extreme, but when you calculate the cost of replacing a HVAC system due to flood damage, it might be worth some discussion.
If you're in the situation where you can't move your HVAC system, or if it's simply logistically impossible to build a higher concrete slab, another solution to improve HVAC flood protection in Scottsdale is to build a protection wall. Many contractors in Scottsdale specialize in designing and constructing an enclosed wall structure that will surround your HVAC system. In this case, they'll make sure to follow local code enforcement and the 100-year flood levels to certify they do the job correct.
Any of these three tips are good ways to ensure you have maximum HVAC flood protection in Scottsdale. It is also a good idea to consider these options if you're in the market for a new HVAC system as moving an existing system can be rather pricy.


this works fine for the purpose as you have asked.
Did you use the pdbqt_to_pdb.py code for converting the pdbqt files to pdb ?
> I already use pymol :).
> I did it, but I am unable to read the sdf with pymol.
> why I was asking for other scripts.
> Or could it be a missing plug-in in the free version of pymol ?
> > without using pdbqt_to_pdb.py or cut -c-66 $f.pdbqt > $f.pdb ?
> > Is a script available somewhere ?
> View your Twitter and Flickr updates from one place - Learn more!


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Intro | Trip Route | Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | Day 6
Three Forks, Montana to Boise, Idaho
Today's Sights: Oxen Statue That Pees | Clubfoot George's Clubfoot | Teton Flood Museum | Birthplace of TeeVee | World Potato Exposition | Atomic City | Shoshone Ice Caves | Evel Knievel Jumpsite
The fabled Oxen Statue That Pees, in Three Forks, MT.
Today's Route:
We stayed in Butte, then headed west to the Oxen Statue. Exit at the junction of I-90 and US287, and look for the Prairie Schooner Restaurant a little north. Then head south on 287 for 50 miles at hyperspeed. Turn west at Ennis for 15 miles to Virginia City and Club Foot George country.
Return east to 287, head south for 40 miles, exit to the right (south) on Rt. 87 in Idaho, which turns into Rt. 20. Stay on 20 for 75 miles into Rexburg for the Teton Flood Museum. The dam site is about 20 miles NE of town off Hwy. 33 (we skipped it). Museum is downtown, 51 N. Center.
Continue on 20 to Rigby, B'place of TV. Then another 35 miles down to Blackfoot, for the World Potato Exposition, 130 NW Main.
Now it's time to stab NW into the wasteland on Rt. 26. It's 30 miles to Atomic City, visible off to the left on an unpaved road. Then get back on Rt. 26 for 6-8 miles, up to the Experimental Breeder Reactor. In Arco, turn SW on Rt. 26/93 for 45 miles (pose for Lunar photo ops at Craters of the Moon N.P. along the way), the turn left onto Rt. 20. Stay on 20 for 19 miles, then head south on Rt. 75 to Shoshone Ice Caves.
Finally, head south for 30 or so miles down Rt. 75 to Twin Falls, site of the Evel Knievel Snake River Jumpsite. Should be getting dark. Jump on I-84 west and get a motel near Boise.
The next day begins with a sunrise visit to the intersection of 287 and I-90 in Three Forks, and that obscure object of our desire, The Oxen Statue That Pees. Yahoo! We made it! In the distance, a cement factory bellows white steam like a geyser. But our attention is focused on "New Faithful," at home in front of The Prairie Schooner Restaurant. New Faithful is one of the two twelve foot-long oxen statues that appear to be pulling the restaurant. When the cashier inside sees us admiring them, she turns a secret handle - and "New Faithful" pees! Regulars leave their guests outside, rush in, and excitedly demand, "Turn him on!"
[August 2001: Several reports verify that the Prairie Schooner Restaurant has been bulldozed and the oxen are gone!]
After seeing New Faithful, we are beside ourselves, and during our next long patch of road the giddiness overtakes us. With "Magnu" pounding, we try to roll down our windows just enough so that the air rushing in vibrates our minivan and creates an infrasound wave which will cause other motorists to lose control of their vehicles.
Infrasound, powerful vibrations of less than 20 cycles per second, was first investigated by French riot police in the 1960s. Our experiment succeeds in spilling Mike's breakfast over Doug's camera bag.
Club Foot George
"Club Foot" George's Club Foot is the Thompson-Hickman Museum's most popular exhibit. It was exhumed from the town's Boot Hill to prove that George Lane was one of the four outlaws lynched in 1863 by an overzealous citizen's coalition. Gnarly, swaddled in burlap, and sealed relic-like in a snowglobesque glass cylinder, it's one of the few displayed American body parts that gets its own postcard.
We race south on 87 into Idaho, avoiding Yellowstone and the Tetons. 'Bagos and sleepy weekend sportsmen clog the roads in these afflicted areas. The way they drive, you'd think there's some kind of law against drinking coffee in this part of the world.
Teton Flood Museum
Rexburg, ID is the site of the Teton Flood Museum. The museum is housed in a former Latter Day Saint church, salvaged after a nine foot wall of water from the Teton Dam's 1976 rupture turned Rexburg into Mudville. The museum is a disappointment - housing only a few mud-caked mementos, photoboards, and a dam model along with dull antediluvian Rexburgabilia. You can buy bottles of "Flood Mud" and "Dam Dirt" at the gift counter, though.
Birthplace of TV
Nearby Rigby was the boyhood home of TV's Dad, Philo Farnsworth, and signs at the city limits proclaim it " The Birthplace of Television." The town museum is located in an old bank building, and the vault enshrines its most precious artifacts - a collection of old TV tubes, a bronze bust of Farnsworth, and some of his personal items and awards.
Volunteer Alice Lufkin, 86, went to high school with Farnsworth. She sits in the vault and tries to provide tourists with a living link to the past. But her secondhand accounts lead us to believe that as an adolescent Lufkin never gave the nerdy Farnsworth the time of day. We do learn that Farnsworth was inspired plowing a potato field, the parallel rows triggering his notion of television scan lines.
[Update: The Rigby Museum has moved out of the bank vault and into an abandoned motel restored by convicts. Also on display are collections of ladies' hats and hide scrapers and, for some reason, a scale model of the Spanish galleon Antocha (sunk in 1622).]
World Potato Expo
More big potato ideas are explained in Blackfoot, where the Idaho Potato Museum homage to the mighty spud. See the world's largest Styrofoam potato, and the world's largest potato chip, a 25-inch Pringle donated by Proctor and Gamble. Ponder the burlap tuxedo worn by the first Potato Commissioner, or the heroic "Potato In Space." The Expo plans to add a simulated potato cellar with authentic smells!
Scenic overlook. Arco, Idaho.
Uncontaminated dust billows from the road as we screech into Atomic City. More than fifty reactors have been built nearby, but today only 25 people live in this flat, isolated ghost town to be. As we explore the streets in our radiation suits, two patrons come out of the combination bar/post office/gas station and do not kill us.
Instead, they recommend the tour of nearby Arco's Experimental Breeder Reactor 1. This was the World's First Nuclear Power Plant. Picnic tables are thoughtfully provided under a pair of house-sized experimental atomic jet engines.
Shoshone Ice Caves
On to Shoshone Ice Caves, just north of Shoshone. A hairy savage clings to a bright green dinosaur statue at the entrance. The cave's rare underground ice accumulation allows for figure skating photos in its brochure. But the hot air constantly let in by tourists makes the actual ice along the cave floor unskatably sloppy. The cave is pleasantly cold, though not very extensive, and there are no old people playing Chinese checkers at the end.
Evel Knievel's Jump Site
The sun plummets, and so do we -- south to Twin Falls and Evel Knievel's Snake River Jump Site. Evel's unsuccessful 1974 attempt to jump across the Snake River Canyon in a rocket powered motorcycle is noted by a small monument in the visitor's center parking lot. The still-extant jump ramp, a big earthen blob, is visible two miles up river.
The drive from Twin Falls to Boise is just as well made at night.
On to Day 4
Feature: Nessie: the Yaquina Bay Monster, Newport, Oregon
Lenny's Laborers, Pottstown, Pennsylvania
AT-AT, Cayce, South Carolina
Peggy Sue's Diner and Diner-Saur Park, Yermo, California
S.S. Minnow, Tehachapi, California


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London Fashion Week A/W 2011: Illustrator Gareth does Menswear Day!
We took illustrator Gareth A Hopkins along to London Fashion Week's Menswear Day to get involved with some live fashion illustration. Here's his personal account of the morning!
Written by Gareth A Hopkins
Jayne Pierson A/W 2011 by Ellie Sutton.
For Jayne Pierson I raced into town alone – yet another early morning show for which we only had one ticket, treat enticingly printed on pearly lilac-y grey paper. This despite a very nice mention of our support in the accompanying press release – thankyou! We did in fact catch up with Jayne just prior to her show, and you can read the interview here. The pearly lilac invite and goodie bag were not, however, an indicator of a colourful show but rather the favoured shade of lipstick. Kingdom of Shadows began on a black note and carried on in the same vein, broken up only by a curious grey and beige striped taffeta that is something of a Pierson signature but would not have looked out of place on curtains or a sofa in a certain type of house.
Jayne Pierson's Kingdom of Shadows by Kerri-Ann Hulme.
Jayne Pierson formerly worked in the music business and this show felt deeply imbued with the remnants of an 80s rock sensibility. A gothic Victorian kind of rock, with swaggering shoulders and bunched bustle skirts. The models sported messy up dos, pallid faces with lilac lips and pin sharp shapely heels. Black tailored jackets featured inset patent fabric shoulders and cuffs, leather minidresses cowl-necked atop rubberised leggings. The sudden introduction of striped silk was balanced with patent detailing on collar, waist and cuffs – a jaunty pillbox hat set askance. Devore lacy velvet also made an appearance, not to mention a terribly racy see through crop top and leggings. I particularly liked the large but lightly draped silver jewellery by Fiona Paxton, who fuses Indian artisanship with a British punk sensibility and Bauhaus design. A corseted jumpsuit that hit the catwalk in a tipsy fashion was less desirable: the poor dresser must have got a shafting but I blame the model's lack of boobs. What's the point of a shaped bodice if there's nothing to put in them?
Jayne took her bow on the catwalk accompanied by her celebrity model – which no one knew. I had to check in with the PR to find out who she was but I can't for the life of me remember – apparently a Welsh singer of some description.
If I'm honest I'm not entirely sure what to make of this collection – there were some nice ideas – especially the strong shoulders and nipped in waists that recalled my fondest decade, the 80s – but it didn't exactly blow me away. And yet again there was all that pesky black, which will never ever be my favourite fashion colour. But I did really love the jewellery – I'd love myself a bit of that I would.
For Jayne Pierson I raced into town alone – yet another early morning show for which we only had one ticket, cialis 40mg enticingly printed on pearly lilac-y grey paper. This despite a very nice mention of our support in the accompanying press release – thankyou! We did in fact catch up with Jayne just prior to her show, viagra order and you can read the interview here. The pearly lilac invite and goodie bag were not, however, an indicator of a colourful show but rather the favoured shade of lipstick. Kingdom of Shadows began on a black note and carried on in the same vein, broken up only by a curious grey and beige striped taffeta that is something of a Pierson signature but would not have looked out of place on curtains or a sofa in a certain type of house.
For Jayne Pierson I raced into town alone – yet another early morning show for which we only had one ticket, clinic enticingly printed on pearly lilac-y grey paper. This despite a very nice mention of our support in the accompanying press release – thankyou! We did in fact catch up with Jayne just prior to her show, buy more about and you can read the interview here. The pearly lilac invite and goodie bag were not, however, an indicator of a colourful show but rather the favoured shade of lipstick. Kingdom of Shadows began on a black note and carried on in the same vein, broken up only by a curious grey and beige striped taffeta that is something of a Pierson signature but would not have looked out of place on curtains or a sofa in a certain type of house.
For Jayne Pierson I raced into town alone – yet another early morning show for which we only had one ticket, remedy enticingly printed on pearly lilac paper. This despite a very nice mention of our support in the accompanying press release – thankyou whoever thought to mention us, clinic it's appreciated! We did in fact catch up with Jayne just prior to her show, and you can read the interview here. The lilac invite and goodie bag were not, however, an indicator of a colourful show but rather the favoured shade of lipstick. Kingdom of Shadows began on a black note and carried on in the same vein, broken up only by a curious grey and beige striped taffeta that is something of a Pierson signature but would not have looked out of place on curtains or a sofa in a certain type of house.
If I'm honest I'm not entirely sure what to make of this collection… there were some nice ideas; especially the strong shoulders and nipped in waists that recalled my fondest decade, the 80s. But it didn't exactly blow me away, and yet again there was all that pesky black, which will never ever be my favourite fashion colour. And I loved the jewellery – I'd love myself a bit of that I would.
For Jayne Pierson I raced into town alone – yet another early morning show for which we only had one ticket, side effects enticingly printed on pearly lilac paper. This despite a very nice mention of our support in the accompanying press release – thankyou whoever thought to mention us, dosage it's appreciated! We did in fact catch up with Jayne just prior to her show, visit and you can read the interview here. The lilac invite and goodie bag were not, however, an indicator of a colourful show but rather the favoured shade of lipstick. Kingdom of Shadows began on a black note and carried on in the same vein, broken up only by a curious grey and beige striped taffeta that is something of a Pierson signature but would not have looked out of place on curtains or a sofa in a certain type of house.
If I'm honest I'm not entirely sure what to make of this collection… there were some nice ideas; especially the strong shoulders and nipped in waists that recalled my fondest decade, the 80s. But it didn't exactly blow me away, and yet again there was all that pesky black, which will never ever be my favourite fashion colour. Here's hoping that the next season might see the reintroduction of colour again. Go on Jayne!
Olivia Rubin A/W 2011 by Jane Young.
Every now and again London Fashion Week throws out a curveball and you end up in the most random of places with the most ridiculous collection of people, physician wondering what the hell is going on. The Olivia Rubin show was just such an occasion.
I was very early to this show – a confluence of circumstances that left me standing at the front of a line outside the Jalouse nightclub in central London until I was completely numb with cold. From my prime vantage point I was able to ogle as the paps pounced on a series of D-Z list celebrities. I recognised Konnie Huq and footballer's wife Danielle Lloyd but after that it was anyone's guess. In my mind it's never a good idea for the guests to overshadow a fashion show, dosage and especially not if I haven't got a clue who they are.
Olivia Rubin A/W 2011. Photography by Amelia Gregory.
Once the celebs had been swept into the hallowed basement of Jalouse I too was invited in. I picked up a drink and swiftly headed towards the sunken seating area, viagra approved ignoring the protestations of the press girl to wait and see if there was space later on. As if! We've run an extensive interview with Olivia Rubin on this website and I didn't much feel like standing around on my own anymore, so I plonked myself down next to a friendly looking bunch of people on a curved sofa. I soon discovered that the lad next to me was on work experience at a fashion magazine and somewhat in thrall to his first fashion week. Herein is revealed the ridiculousness of seating arrangements at fashion shows – at the end of the day they are completely arbitrary. Depending on who you know and whether you're bolshy enough you can sit wherever you want, be you intern or editor.
Olivia Rubin by Karolina Burdon.
As guests slowly filled the club celebrities stepped up on to the catwalk at my head height to pose for the paps. First Danielle, swishing her hair this way and that like a prime racehorse. Then, to my delight, Laura Goodger and friends from The Only Way is Essex. Don't worry, I had to look up her full name. I did watch a few episodes, but I'm not THAT SAD. By this point I was gobsmacked by the stunning level of celeb-dom in attendance. I later discovered that another fashion PR had been approached for tickets by the *cast* of The Only Way is Essex, but had rapidly turned them down as way too tacky. I must say, I don't really understand the logic. Rather than making me think, way-hey, this must mean Olivia Rubin is really cool… it makes me utterly distracted… anthropologically fascinated by these strange creatures.
The result? I spent the entire catwalk show trying to capture Lauren pouting and preening, rather than concentrating on the clothes – which in any case were hard to see against the glare of flashbulbs. Famous model Olivia Inge certainly enjoyed herself too; gunning at friends in the audience as she pranced down the catwalk.
In a way it's a shame that there was so much flimshaw surrounding this show because Olivia Rubin makes very cute clothes that feature colourful, fun prints and simple 80s styling. This collection encompassed giant splodgy animal prints, flowery brick designs and lacey goodness. To my mind not at all Essex.
As soon as the show was done the music leapt up to dancing volume, and yet more Essex girls headed to the toilets to touch up wondrously over-wrought hair and make-up that must surely have taken all day to perfect. I could happily have stayed next to the basins all night with my camera, but Matt and I instead drank free cocktails and put the world to rights.
You can read Matt Bramford's fabby review here. Read our interview with Olivia Rubin here.
Every now and again London Fashion Week throws out a curveball and you end up in the most random of places with the most ridiculous collection of people, viagra sale wondering what the hell is going on. The Olivia Rubin show was just such an occasion.
I was very early to this show – a confluence of circumstances that left me standing at the front of a line outside the Jalouse nightclub in central London until I was completely numb with cold. From my prime vantage point I was able to ogle as the paps pounced on a series of D-Z list celebrities. I recognised Konnie Huq and footballer's wife Danielle Lloyd but after that it was anyone's guess. In my mind it's never a good idea for the guests to overshadow a fashion show, seek and especially not if I haven't got a clue who they are.
Once the celebs had been swept into the hallowed basement of Jalouse I too was invited in. I picked up a drink and swiftly headed towards the sunken seating area, ignoring the protestations of the press girl to wait and see if there was space later on. As if! We've run an extensive interview with Olivia Rubin on this website and I didn't much feel like standing around on my own anymore, so I plonked myself down next to a friendly looking bunch of people on a curved sofa. I soon discovered that the lad next to me was on work experience at a fashion magazine and somewhat in thrall to his first fashion week. Herein is revealed the ridiculousness of seating arrangements at fashion shows – at the end of the day they are completely arbitrary. Depending on who you know and whether you're bolshy enough you can sit wherever you want, be you intern or editor.
As guests slowly filled the club celebrities stepped up on to the catwalk at my head height to pose for the paps. First Danielle, swishing her hair this way and that like a prime racehorse. Then, to my delight, Laura Goodger and friends from The Only Way is Essex. Don't worry, I had to look up her full name. I did watch a few episodes, but I'm not THAT SAD. By this point I was gobsmacked by the stunning level of celeb-dom in attendance. I later discovered that another fashion PR had been approached for tickets by the *cast* of The Only Way is Essex, but had rapidly turned them down as way too tacky. I must say, I don't really understand the logic. Rather than making me think, way-hey, this must mean Olivia Rubin is really cool… it made me utterly distracted… anthropologically fascinated by these strange creatures.
The result? I spent the entire catwalk show trying to capture Lauren pouting and preening, rather than concentrating on the clothes – which in any case were hard to see against the glare of flashbulbs. Famous model Olivia Inge certainly enjoyed herself too; gurning at friends in the audience as she pranced down the catwalk.
J.W. Anderson (not Gareth) photographed by Matt Bramford
It's 8:45 on a cold wet Wednesday and I'm stalking the entrance to Somerset House, order waiting for Matt Bramford to come and meet me for my first ever day of London Fashion Week, check which I've come to with a view to doing some live fashion illustration. I'm feeling surprisingly calm, considering how out of my depth I'm expecting to find myself. I put my serenity down to sleep deprivation, busying myself with not looking too out of place. At the point where the security guards are starting to wonder what I'm hanging around for, Matt texts me and I amble off, as coolly as I can, to meet him at the doors into the main 'Tent'.
As I arrive, Matt hands me my Press Pass and I feel like he's given me a Willy Wonky Golden Ticket which provides access to a new and magical world. I flash it on the way into the Press Room where Matt picks up his stuff, hands me the ridiculously over-sized invitation to J.W. Anderson and we're out again, straight into the queue for the show. The bouncer in charge of the queue takes a look at our invites and sends us to opposite sides of the room. I experiment with making myself look natural in my surroundings, the queue that Matt's in gets allowed through, and once that's cleared, my queue starts shuffling forward.
J.W. Anderson, photographed by Matt Bramford
I'm allowed past some rope barriers into the main room, and am… well, not unimpressed, rather just not as overwhelmed as I'd prepared myself for. The room's long and poorly lit, its sides lined with rows of wooden benches, and a polythene-covered runway running up the middle – I don't know what I was expecting, but this is a lot plainer than I'd thought it was going to be. I make my way over to the row of benches dictated by my ticket, and then busy myself with getting my video-camera, pad and pens ready. As the room settles down I realise that in an almost-full room, I've got an entire bench to myself, and am not sure whether to feel lucky or to take offence.
All illustrations by Gareth A Hopkins
The room hushes as the polythene sheet is pulled away by some burly stagehands and then before I'm really ready for it the lights are on full-blast and there's a man marching down the catwalk. I pop the lid off my pen, put the nib to the page and the model's already been and gone. I wait for the next few guys to come and go, then pick my target and start frantically sketching. By the time he's tucked away backstage I've managed to capture the top corner of his sleeve and that's it. I write in my sketchbook "Shit, I can't draw this fast" and get out my video camera, with a view to capturing the outfits and then working from the videos – the trouble is the lights are so bright that all I get on the viewing screen is a bright white shape moving at speed, like the aliens from Cocoon are parading for a crowd assembled in a gymnasium.
I realise that I'm not going to achieve very much through either drawing or filming, and so instead take the opportunity to enjoy the show, and concentrate on the clothes as much as I can. The clothes are sharply tailored, often military-style, but made out of combinations of textures and textiles – a jumper with furry arms and Barbour-style body for instance. There are also some skirts in there, which I think look pretty cool. The only thing I'm not keen on is the use of paisley, which of all patterns in the world is probably my least favourite. And then 'Wave Of Mutilation' by Pixies is playing over the PA and all the models are walking in a line to applause from the audience – in joining in, I manage to drop both my camera and my pad, and spend this final section of the show flicking my attention between applauding, watching the clothes and trying to find my dropped possessions.
After it's all over I re-locate Matt, who asks if I got much done, and I explain about my inability to draw as fast as I needed to. He reassures me by saying that next up is Sibling, who are holding a presentation, and that I'll have much more time to get some decent drawing done. With some time to kill, we wait outside in the thankfully quite mild weather. Nick Bain comes and joins us after a while and tells us about Charlie Le Mindu's show from earlier in the week and I feel a little disappointed that none of the models from JW Anderson's show were covered in pig's blood.
As 10:30am rolls around, we make our way up to the Sibling presentation. I don't know what to expect from Sibling – I'd researched them in preparation and in all honesty wasn't that fussed about them. Their mix of high fashion and self-aware bloke-ishness didn't really do anything from me, but I kept an open mind. I know Nick loved the clothes on show, but I still can't get behind it – I find their use of the 'Kiss Pandas' a bit boorish, and this combined with a inbuilt distrust of knitted ski masks and people dressed as pandas puts me on edge. That's not to say I hate it, though – there's a furry headwear/scarf combination that I wish I could get away with wearing, and I really like some of the jumpers. I manage to get some sketching of two of the outfits done, but find myself being more and more in the way of people with cameras and notebooks and pens tapping against their lips, and sidle out of the room after Matt and Nick.
Sibling, photographed by Matt Bramford
Once outside I make the most of my half-day from work, and go back to my office for a few hours, to return for some more catwalk shows in the afternoon…
Look out for the rest of Gareth's account tomorrow!
See Gareth's illustrations in Amelia's Compendium of Fashion Illustration
Written by Gareth A Hopkins on Tuesday March 8th, 2011 3:30 pm
A/W 2011, Barbour, Charlie le Mindu, Cocoon, fashion, illustration, J.W. Anderson, Kiss, London Fashion Week, Matt Bramford, Menswear Day, Nick Bain, Pandas, Portico Rooms, press, Sibling, Somerset House, the pixies, Wave of Mutliation, Willy Wonka
London Fashion Week A/W 2011: Illustrator Gareth does Menswear Day, part two!
London Fashion Week Menswear Day A/W 2011 Presentation Review: SIBLING
London Fashion Week S/S 2012 Menswear Day Presentation Review: SIBLING
London Fashion Week S/S 2011 Presentation Review: Sibling
London Fashion Week S/S 2011 Preview – A few more favourites…
2 Responses to "London Fashion Week A/W 2011: Illustrator Gareth does Menswear Day!"
Liam McMahon says:
Hahaha, "Shit, I can't draw this fast…".
I would epically fail doing this.
I think I'd have a nervous break down mid show.
Good work though
Matilde Sazio says:
Hilarious Gareth, well done x


In the past we discussed exactly how you should structure your workouts. After getting some questions about that post, I have decided to put an article together discussing the flow of your workouts.
Pre-Gym Preparation: The two main points you need to remember for your pre-gym preparation are nutrition and having a plan. Let's first discuss nutrition. Everyone is different when it comes to when they can eat before a workout. For myself, I can eat up to 30 minutes before and be completely fine while others need at least 2-3 hours to let their food digest.
It really just depends on how you handle food before working out. Figure out when that time is and stick with it. Pre-workout meals should consist of some protein and carbs coming from fruit. Your best options will be strawberries, raspberries, black berries, or blueberries. Protein should can be chicken, fish, beef, or a protein shake.
In the past, we have discussed the importance of having a plan when getting to the gym. The last thing you want is to be walking around wondering what you will be doing next. Not only will you be wasting time but your workouts will suffer.
Write out a plan on your smart phone, piece of paper, in a notebook, or even on a napkin before you get to the gym. Your plan should include what exercises you will do, the amount of reps and sets, rest periods, and how long your workout will take.
The Warm-Up: After you get to the gym and getting changed, it is time to prepare for your workout. Most people recommend going up and doing some cardio before the workout, but not me. A better and more productive warm-up will depend on what you are doing that day and will consist of dynamic stretching and bodyweight exercises.
The dynamic stretching (or active stretching) will get your muscles loosened up and ready to go. You will then perform some bodyweight exercises replicating the workout that you will do that day. If you are going to be doing squats, then in your warm up you would do some bodyweight squats, lunges, and squat jumps to get your legs going.
After going through a 5-10 minute warm up, it is always recommended that you do at least two sets of the first exercise on your list with lighter weight. So if you are doing barbell squats as your first exercise, do at least two sets with a lighter weight before jumping into your actual workout.
First 10-25 minutes: Within the first 10-25 minutes of your workout, you should do your hardest exercises first. So sticking to our theme, if you are doing legs that day, you would want to do squats and deadlifts first before moving on to the less demanding exercises.
Middle 5-10 minutes: You have gotten through the toughest part of your workout and are now on to the middle 5-10 minutes. Most times, this is when you are starting to feel the affects of the first 10-25 minutes but still have a few more exercises written on the plan you put together earlier.
During this portion of the workout, it is a good idea to do some isolation exercises if you have them on the list. For example, this is when you would do your leg extensions, leg curls, calf raises, bicep and tricep work, etc.
It is always best to save your isolation movements toward the end of the workout as they are much easier on your body to perform, and frankly it doesn't really matter if your muscles are tired when performing them. It is much more important to go hard on squats, deadlifts, and leg press than it is on hamstring curls.
Last 5-10 minutes: The end of your workout is when you should perform your ab work and/or a finisher. If you have abs on the list that day, simply doing 2-3 exercises and repeating for 2-3 sets always works great.
As for a finisher, this will be a set of exercises that are very high intensity targeting similar muscle groups as your workout that day. For example, on a leg day you could do squat jumps, leap ups, jump lunges, burpees, rock climbers, etc.
A finisher is meant to be very high intensity for this short period of time. This is all the cardio you need for your workouts! You don't need to go up and do 45 minutes of cardio after weight training if you perform your finishers properly.
Post Workout (5-10 minutes): Post workout is when you will cool down, foam roll, and stretch. I always like foam rolling and static stretching as a cool down period. Having a cool down will help you relax and recover better for your next workout.
Post Post Workout: After your cool down period, it is time for your post workout meal. As we already know, nutrition is 80-90% of the results you will see so your post workout nutrition is very important.
This meal should consist of a good, quick source of protein and some complex carbohydrates. The quickest way to get your protein is through a protein shake. Just mix it with water and you are good to go. Depending on your goals you can include 25-100 grams of complex carbohydrates immediately after your workout.
This will help with recovery and lean muscle growth!
Final Words: No matter what workout you go through, the structure above can be used as a guide. Start with writing out your plan and fueling your body, warm-up properly, go hard during your workout, cool down, and get some good post workout nutrition.
Remember that nutrition is 80-90% of the results you will see so don't think that just because you worked out, you can go off and eat anything you want. Focus on eating real foods, and lots of them. If you do this, the results you want will come.
P.S. Like this post? Then hit the 'Like' and Tweet button before you go!


Author(s): Riksen, N.P. ; Smits, P. ; Rongen, G.A.P.J.M.
In the concentration range that is normally achieved in humans, e.g., after the drinking of coffee or in patients treated with theophylline, the cardiovascular effects of methylxanthines are primarily due to antagonism of adenosine A(1) and A(2) receptors. Inhibition of phosphodiesterases or mobilization of intracellular calcium requires much higher concentrations. In conscious humans, acute exposure to caffeine results in an increase in blood pressure by an increased total peripheral resistance, and a slight decrease in heart rate. This overall hemodynamic response is composed of direct effects of caffeine on vascular tone, on myocardial contractility and conduction, and on the sympathetic nervous system. Caffeine is the most widely consumed methylxanthine, mainly derived from coffee intake. Regular coffee consumption can affect various traditional cardiovascular risk factors, including a slight increase in blood pressure, an increase in plasma cholesterol and homocysteine levels, and a reduced incidence of type 2 diabetes mellitus. Although most prospective studies have not reported an association between coffee consumption and coronary heart disease, these findings do not exclude that the acute hemodynamic and neurohumoral effects of coffee consumption could have an adverse effect in selected patient groups who are more vulnerable for these effects, based on their genetic profile or medication use.


Arithmetic & Geometric Sequences. Name _____ Find the next three terms in each sequence. Then, identify the rule and write whether each sequence is arithmetic or geometric.... We introduce one of the most important types of series: the geometric series. We will use geometric series in the next chapter to write certain functions as polynomials with an infinite number of terms. This process is important because it allows us to evaluate, differentiate, and integrate complicated functions by using polynomials.
Search this site. 208 days since First Day of Exams. 207 days since Baby Younts' Due Date! mock interview questions answers pdf One of these series is geometric, one of the series is arithmetic and the other two are neither geometric nor arithmetic. (a) Complete the table by stating the type of series that is shown.
One of these series is geometric, one of the series is arithmetic and the other two are neither geometric nor arithmetic. (a) Complete the table by stating the type of series that is shown.
An arithmetic sequence has first term a and common difference d, d ≠ 0. The 3 rd , 4 th and 7 th terms of the arithmetic sequence are the first three terms of a geometric sequence.


text:
New STEM building in pre-design phase
Campus Life Features
Campus Life News
By Kathryn Scott 11 months ago
Kathryn Scott
Plans are underway to add a new building to the Puyallup campus. The building will provide specialized labs and equipment for STEM-related classes. STEM, which stands for science, technology, engineering and math, are increasingly popular career pathways chosen by students.
The number of students enrolled in biology, chemistry, engineering and physics programs has almost doubled in size since 2010. These programs are some of the core disciplines of STEM. These students are using the same labs and classrooms that came with the campus, meaning there isn't enough space for all of them.
"At Puyallup, we don't actually have enough space for all the different classes we're trying to run, we just have more students than space," said Choi Halladay, vice president of administrative services.
Construction of the new building is still several years out, and the location of the building is currently unknown, but college officials are looking at potential plans for purchasing land adjacent to the campus.
"We'll be doing the design of that (STEM) building over the next year, trying to figure out how to build a state-ofthe-art building," Broxson said.
The project will cost about $36 million to $38 million and will house general classrooms, but the rooms will mostly be related to STEM, such as science labs and a wing dedicated to engineering. Additional parking is a separate project that is also being looked at. After the new building opens, the plan is to eventually remodel the labs in the Brouillet Library Science building to convert them into more general classrooms.
The goal of this is to someday have all STEM-based classes and labs located within their own building. With companies such as The Boeing Co. and Microsoft, aerospace and software industries are especially prominent in the Puget Sound.
"A lot of the industries have really led to the economic growth we've seen in Pierce County, and the Puget Sound area in general are STEM based," said Tom Broxson, dean of science and math at Pierce College.
The cost of living is also more expensive than in years past, leading more individuals nationwide are pursuing STEM careers due to the higher paying wages. However, the increasing number of students has outgrown the current labs offered on the Puyallup campus.
There's an increase in the STEM industries worldwide as well, with more people in the STEM field being brought into the area for work from out of state, as opposed to local workers. The increasing availability, demand and pay for these jobs makes a career relating to STEM appealing to some students.
According to Broxson, the Puyallup campus has a higher number of students pursuing a STEM pathway than at the Fort Steilacoom campus. Fort Steilacoom has a state-of-the-art building, but Broxson theorizes that the higher number of STEM students at Puyallup is possibly related to the number of registered students who have parents or relatives that work in the field. Students aiming for STEM careers are either pursuing associate degrees at Pierce and transferring to four-year universities or are pursuing primarily associate of science degrees.
Kathryn Scott is the Managing Editor here at The Post.
This is her second year at Pierce and, although she doesn't quite know what she's doing or where she's going after graduation, she's determined to make the most of anything and have fun while doing it. She doesn't like being on the sidelines, which is why she always tries to be as involved with any activity as much as possible. Kathryn has a strong desire to want to get things organized and completed. She loves walking, hiking, cleaning and challenging herself. Along with laughter, these are a type of therapy for her.
She firmly believes in teamwork with plenty of communication. Wherever these are lacking, she hopes to be able to provide. She classifies herself as an extroverted introvert (or an ambivert). Kathryn's always ready for a challenge and enjoys getting to know new people. However, she's got no problem just spending a quiet evening at home.
Kathryn and her husband are on the young adult leadership team for their parish. She's grateful for the opportunities provided by both her parish and Pierce.
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What 2020 has taught me so far - June 12, 2020
Thank You Pierce Professors: Emily Kang - June 10, 2020
Previous College expands to Spanaway Lake High School
Next Students now can receive budgeting help on campus
by Kathryn Scott time to read: 2 min
Campus Life	Students now can receive budgeting help on campus…
Campus Life	College expands to Spanaway Lake High School