text:
In this section: Recalls, Market Withdrawals, & Safety Alerts
Recalls, Market Withdrawals, & Safety Alerts
Recall Resources
Enforcement Reports
Industry Guidance For Recalls
Major Product Recalls
Archive for Recalls, Market Withdrawals & Safety Alerts
Serafin Fishery Issues Allergy Alert on Undeclared Anchovies, Eggs, Milk and Soy in Salmon Dip and Whitefish Dip
This recall has been completed and FDA has terminated this recall.
When a company announces a recall, market withdrawal, or safety alert, the FDA posts the company's announcement as a public service. FDA does not endorse either the product or the company.
Read Announcement View Product Photos
Company Announcement Date:
FDA Publish Date:
Seafood/Seafood Product
Reason for Announcement:
Recall Reason Description
Undeclared Eggs, Milk, Anchovies, and Soy
Serafin Fishery
Brand Name(s)
Salmon Dip and Whitefish Dip
Serafin Fishery is recalling its 8-ounce containers of Salmon Dip and Whitefish Dip because they may contain undeclared anchovies, eggs, milk and soy. People who have allergies to anchovies, eggs, milk and soy run the risk of serious or life-threatening allergic reaction if they consume these products.
The recalled Salmon Dip and Whitefish Dips were distributed locally in retail stores. The product comes in an 8-ounce, clear plastic package marked with lot #729 and lot #807 on the top and with expiration dates of August 12, 2020 and August 24, 2020 on the label.
No illnesses have been reported to date in connection with this problem.
The recall was initiated after it was discovered during an inspection conducted by the Michigan Department of Agriculture and Rural Development that the products' labeling did not list all of the products' ingredients. Production of the product has been suspended until FDA and the company are certain that the problem has been corrected.
Individuals with an allergy or sensitivity to anchovies, eggs, milk and soy should not consume these products. Households that include individuals with an allergy or sensitivity to any of these allergens should dispose of the recalled product. Consumers who have purchased the 8-ounce packages of Salmon Dip and Whitefish Dip are urged to return them to the place of purchase for a full refund. Consumers with questions may contact Serafin Fishery at 1-989-879-4596 , Monday thru Friday from 9 to 5 p.m.
Consumers:
serafinfishery@gmail.com
Follow @FDArecalls on Twitter
Recent Recalled Product Photos on FDA's Flickr Photostream
More Recalls, Market
Withdrawals, &


text:
Doing All Of The Things
Coping Mechanisms
November 10, 2022 November 10, 2022 | in Coping Mechanisms, Grief, Hope for Widows Foundation, Mental Health, Solo Parenting, Widowhood Journey| by Layla Beth Munk
In just barely over three short months, I will have been widowed for five years.
Some days it feels like it's been decades and that I really and truly know how to make it without a partner.
Other days, I'm reminded of just how much I don't know and it all still feels so new.
Two minor "disasters" that were very much under the umbrella of my late husband's expertise occurred just days ago.
My laptop went completely kaput. Bret handled all of our tech stuff, even though I'm not completely out to lunch when it comes to tech. He was a Mac guy and managed to switch me over from PC not too long after we got together.
Even though I've handled all the technology upgrades in my home since his passing, I hadn't had to break in a new laptop yet.
I get really stressed out having to learn all the different ins and outs of each subsequent upgrade, so the last few weeks haven't exactly been rainbows and butterflies for me.
Without my dad and my daughter, it would have been much worse, and as it stands now I have a brand new functional MacBook. (I'm still getting used to it though, hence my writing this blog on my phone!)
And then there was my headlight…
Headlights on cars go out all the time, right?
Well, I had never dealt with one on my own before until last week. Dear ol' Dad was out of town too, but he told me via text to take it to O'Reilly's and they would even install it for me!
This news was like a miracle to me.
I was so happy about it that I posted about it on the Hope For Widows Facebook group where others responded with additional helpful hints on the same lines. (Things like how certain autoparts stores will do batteries and wiper blades as well.)
I have blogged about little wins like these before, as well as the times that sure don't feel like wins. And just when I think that I've got it all under control, something "new" comes right back up!
Fear sets in and I start worrying that I'll never really know how to do it all. But then I remind myself that so far, I've been okay.
I've had help, yes, but at the end of the day, I'm learning how to handle it all on my own and I'm doing okay.
I've learned so much in these last five years that I can't help but feel proud of myself! I don't think he would've ever believed that I could do life on my own like this.
Sometimes, it feels like too much, though and I find myself getting really frustrated at being the only one in charge.
But then I just remind myself of all the other things that I've mastered over these last few years, and then the pride I feel vastly overshadows that fear.
We can handle this and we will get by.
We got this.
Pic via Pngitem
Looking for a way you can make a difference and give back this holiday season? Embrace the spirit of giving by participating in Hope for Widows Foundation's third annual 'Bring Hope' virtual program that directly assists a widow's family who cannot provide gifts for their children or other necessities during this holiday season. Some widows who are struggling to make ends meet during this time simply do not have the luxury of purchasing gifts when their finances require them to choose between keeping the lights on and food on the table or purchasing presents. Add in the factors of solo parenting, grief, and the emotional and physical toll it takes. If you would like more details on how you can support a widow and her family, please EMAIL US directly for questions at info@hopeforwidows.org or to sponsor, go here for details and to fill out the application: https://linktr.ee/hopeforwidows
PS. Happy birthday, Bret. 🖤
11-10-70 – 2-11-18
About Layla Beth Munk
Layla Beth Munk is a blogger & author who was thrust into this widowhood journey abruptly and tragically on February 11, 2018. Her husband of 12 years had ended his pain once and for all. She soon made the decision that she would not let his final decision define the rest of her life or their daughter's life, so with her sense of humor at the helm, she started writing about her newfound station in life. Grief waves still get to her, and probably always will, but with the help of her fellow widows as well as my friends and family, she has been able to realize her dream of becoming a published author! Layla is so grateful to Hope For Widows Foundation for providing this level of support to her, and so many others! Layla has two amazing children, one who is grown and one who is almost grown. She lives in eastern Oregon and has a wellness & beauty background. Layla enjoys writing poetry, watching anime, and homeschooling her daughter.
Her blog can be found at laylabethmunk.medium.com and her debut novella, 24 Hours in Vegas, is available on Amazon.
Tags: #bloggingwidow,#hopeforwidows,#hopeforwidowsfoundation,#widow #youngwidow,#widowshelpingwidows,practical help for widows,widowhood
Layla Beth Munk
Layla Beth Munk is a blogger & author who was thrust into this widowhood journey abruptly and tragically on February 11, 2018. Her husband of 12 years had ended his pain once and for all. She soon made the decision that she would not let his final decision define the rest of her life or their daughter's life, so with her sense of humor at the helm, she started writing about her newfound station in life. Grief waves still get to her, and probably always will, but with the help of her fellow widows as well as my friends and family, she has been able to realize her dream of becoming a published author! Layla is so grateful to Hope For Widows Foundation for providing this level of support to her, and so many others! Layla has two amazing children, one who is grown and one who is almost grown. She lives in eastern Oregon and has a wellness & beauty background. Layla enjoys writing poetry, watching anime, and homeschooling her daughter. Her blog can be found at laylabethmunk.medium.com and her debut novella, 24 Hours in Vegas, is available on Amazon.
All Posts by Layla Beth Munk
Missing the feeling of him
12 Months of Remembering and Grieving

redpajama_set_name: RedPajamaCommonCrawl


text:
Bridges by County
Bridge Blog
Construction Complete for Route 394 Bridge Project in Butler Township
See below for more information on the Rapid Bridge Replacement Project
The Route 394 bridge, which spans Conewago Creek in Butler Township, Adams County, that's been under construction as part of the Pennsylvania Department of Transportation's Rapid Bridge Replacement Project, is complete and open to traffic. Replacement of the bridge allows PennDOT to remove it from Adams County's structurally deficient bridge list.
The bridge reopened to traffic on Friday, May 4. Replacement work was performed by Clearwater Construction.
The new crossing is longer and wider than the one it replaced and is designed with a 100-year lifespan.
This bridge is referred to as JV-228 and is one out of the 558 bridges being replaced under the Rapid Bridge Replacement Project. JV references the joint-venture partnership between Walsh/Granite, which is leading construction for the entire project.
About The Project | Contact Us
2000 Cliff Mine Road, Suite 300
info@parapidbridges.com
Hours: M–F from 8:30 a.m. – 5 p.m. ET
Contact: Rory McGlasson, 412.500.6695
Plenary Walsh Keystone Partners believes in engaging local community and disadvantaged business enterprise (DBE) resources to benefit our projects and the communities in which we do business. We seek to establish relationships with local DBE firms, encourage and assist potential DBEs to obtain necessary certification and prequalification, and aid development of DBEs through their active involvement.
View Available Jobs An Equal Opportunity Employer, Disability/Veteran.
Copyright © 2015 Plenary Group | Walsh Group | Granite | HDR. All rights reserved.
website design by xdevgroup a chicago website company


text:
Please note that your account has not been verified - unverified account will be deleted 48 hours after initial registration. Click anywhere on the bar, to resend verification email.
KPMG Personalization
Get the latest KPMG thought leadership directly to your individual personalized dashboard
Global Climate Response
KPMG firms play their part in addressing pressing global issues such as climate change.
› Global Climate Response
The global green initiative
KPMG's Global Climate Response was launched in 2008 with the aim of significantly reducing KPMG's environmental impacts across KPMG member firms globally. Since 2010, we've reduced net emissions per full-time equivalent (FTE) by 24 percent. Notably, KPMG's total "gross" greenhouse gas emissions are now beginning to lower even with significant employee and revenue growth. KPMG member firms also continue to recognize the benefits of procuring renewable energy, with 42 percent of our purchased electricity in 2017 coming from renewable sources. The move towards 'green buildings' and investments in energy efficiency has resulted in a 17 percent decrease in energy use (kWh) per square meter.
Now in its third phase, KPMG's Global Climate Response aims to reduce environmental impact across the global network by a further emission reduction target of 10 percent net per full-time equivalent between 2016–2020. To meet our climate targets, phase 3 also includes a global renewable energy target of 60 percent of purchased electricity to come from renewable sources by 2020.
Through the GCR, KPMG member firms are also committed to reducing their impact on the environment, addressing local environmental challenges and working with clients to advance environmental sustainability.
Actions include:
developing new approaches to account for natural and social capital
supporting collaborative projects with partners such as the UN Global Compact and the World Business Council for Sustainable Development (WBCSD)
serving as leading providers of climate change and sustainability services for clients.
UNFCCC COP23
COP23, the UN Climate Conference, took place between 6 to 17 November 2017 in Bonn, Germany, and was presided over by Fiji.
COP23 is the second UN Climate Conference after the historic 2015 conference in Paris (COP21) where almost 200 countries committed to reduce their own carbon emissions in order to halt global warming and create a carbon-neutral world. Nations of the world meet to advance the aims and ambitions of the Paris Agreement and achieve progress on its implementation guidelines.
KPMG was proud to support COP23 by collaborating with the UN Climate Secretariat. Together we presented UN Climate Talks LIVE: a window into the global social media conversation on COP23.
Climate-related financial disclosures
KPMG recognizes that climate change will have significant impacts across many business sectors and we support stronger disclosures of climate-related risks and opportunities. Such disclosures are an important step in using market forces to drive more efficient allocation of capital and the transition to a low-carbon economy. KPMG participated in the Financial Stability Board's Task Force on Climate-related Financial Disclosures (TCFD) and we believe climate-related risks, like other risks, should be an integral part of our reporting.
We have incorporated our disclosures in KPMG's International Annual Review and below:
Governance - climate-related risks and opportunities
Since 2010, the Global Board of KPMG International has received an annual update on KPMG's GCR, detailing progress in reducing emissions. In light of the TCFD recommendations, the update has extended to include potential risks and opportunities on climate-related issues for KPMG member firms. In addition, we have developed guidance for KPMG member firms to share with clients to help them better consider the financial impacts of climate change, including the challenges and opportunities.
Climate-related risks and opportunities
We believe KPMG's biggest contribution is through member firms helping clients in understanding the potential effects of climate change, in determining the impacts of certain climate scenarios, in establishing management, reporting and monitoring systems and in appropriate disclosure of the financial risks of climate change.
We also anticipate potential new services to be an opportunity for member firms to support clients. While these climate-related services will be very relevant for the future, the financial results from new services will likely be limited in comparison to our combined global revenues.
As a result of our review of the potential impact of climate-related risks and opportunities, we have considered a number of aspects as being potentially material to the network. These include disruption to operations, reputational risks and operational improvements, which are being managed through member firm facilities and IT departments as well as efforts to reduce impacts on climate change.
We report carbon emissions annually (see below) and provide additional climate-related disclosures in our annual response to the CDP (formerly known as the Carbon Disclosure Project).
Find office locations kpmg.findOfficeLocations
Email us kpmg.emailUs
Want the latest KPMG {tag_name} content?
Register now and set up your personalized dashboard around {tag_name} and all the other topics that interest you.
Find out how KPMG's expertise can help you and your company.
Subscribe to KPMG Insights
Footer Subscription
© 2020 KPMG, a Sri Lankan partnership and a member firm of the KPMG network of independent member firms affiliated with KPMG International Cooperative ("KPMG International"), a Swiss entity. All rights reserved.


text:
What the pope said when Martin Luther King was killed
Rev. Dr. Martin Luther King during the March on Washington, 1963. Credit: public domain
Memphis, Tenn., Jan 20, 2020 / 11:35 am MT (CNA).- On April 4, 1968, Martin Luther King, Jr., was fatally shot outside his room at the Lorraine Motel in Memphis, Tennessee.
King is remembered as the most visible leader of the civil rights movement, for which he was awarded the Nobel Peace Prize in 1964, and as the founding president of the Southern Christian Leadership Conference. But he was first a pastor at Dexter Avenue Baptist Church in Montgomery, Alabama, and remained active in pastoral leadership throughout his life.
On the day after King was killed, Pope Paul VI expressed remorse during his Angelus address, saying that the civil rights leader was "a Christian prophet for racial integration."
Shortly after King's death, the National Conference of Catholic Bishops, the National Council of Churches, the Synagogue Council of America, and the Standing Conference of Orthodox Bishops in the Americas released an interfaith statement, mourning their colleague in ministry.
We "bow together in grief before the shameful murder of Dr. Martin Luther King, Jr., a unique apostle of the non-violent drive for justice, [and] affirm that no service of remembrance or local memorial is equal to the greatness of his labor or the vastness of our national need."
The faith leaders also applauded the efforts of Congress to pass the Civil Rights Act of 1968, encouraged Americans to support measures favoring integration, and pled with government officials to fund legislation aimed at fighting poverty.
We "affirm that only through massive contributions by the American people can this nation duly honor the life-offering of Martin Luther King, Jr. and responsibly lift up the burden of the poor and oppressed in our land."
The statement also promised to implement coordinated efforts among religious communities to fight poverty.
We "declare our intention to take immediate steps to develop a coordinated sacrificial effort on the part of the American religious community to help the disadvantaged," the statement read.
Faith leaders were not the only ones to pay tribute to King after his assassination.
On the night King was killed, Senator Robert Kennedy, a Catholic, spoke to the people of Indianapolis, urging them to greater compassion and a deterrence from violence. Kennedy spoke during a stop on his 1968 campaign for President, delivering the news to a multiracial crowd that King had been assassinated.
"What we need in the United States is not division; what we need in the United States is not hatred; what we need in the United States is not violence or lawlessness; but love and wisdom, and compassion toward one another, and a feeling of justice toward those who still suffer within our country, whether they be white or they be black," he said on April 4, 1968.
Kennedy referenced the assassination of his own brother, President John F. Kennedy, which had taken place in 1963.
"For those of you who are black and are tempted to be filled with hatred and distrust at the injustice of such an act, against all white people, I can only say that I feel in my own heart the same kind of feeling. I had a member of my family killed, but he was killed by a white man. But we have to make an effort in the United States, we have to make an effort to understand, to go beyond these rather difficult times," Kennedy said.
The senator urged Americans to take up King's efforts, pray for King's family and the nation, and join in solidarity those longing for peace.
"The vast majority of white people and the vast majority of black people in this country want to live together, want to improve the quality of our life, and want justice for all human beings who abide in our land," he added.
"I shall ask you tonight to return home, to say a prayer for the family of Martin Luther King, that's true, but more importantly to say a prayer for our own country, which all of us love--a prayer for understanding and that compassion of which I spoke."
This article was originally published on CNA April 3, 2018.
Tags: Catholic News, Martin Luther King Jr, Pope Paul VI
Martin Luther King Jr hailed as an example of 'artisans of peace'
Cardinal Daniel DiNardo of Galveston-Houston has called civil rights leader Martin Luther King...
Catholic bishops: US still 'painfully' far from Martin Luther King's dream
The example of Martin Luther King, Jr., is still sorely needed in the United States, given...
The nuns who witnessed the life and death of Martin Luther King
Last year's Martin Luther King Jr. Day marked the first without Sister Mary Antona Ebo, the only...


text:
Integrated analysis of differentially expressed long noncoding RNAs and mRNAs associated with high-fat diet-induced hepatic insulin resistance in mice
Zengyuan Zhou ORCID: orcid.org/0000-0001-7216-31651 na1,
Xue Zhao1 na1,
Liang Chen1,
Yuzheng Li1,
Zhao Chen1,
Yuanyuan Wang1,
Zihao Zhou1 &
Xia Chu1
Hepatic insulin resistance (IR) is an early pathological characteristic of many metabolic diseases, such as type 2 diabetes. Long noncoding RNAs (lncRNAs) have been identified as mediators of IR and related diseases. However, the roles of lncRNAs in hepatic IR remain largely unknown.
High-throughput sequencing was performed on ten liver tissue samples from five normal diet (ND)-fed mice and five high-fat diet (HFD)-induced hepatic IR mice, respectively. lncRNAs and mRNAs that were differentially expressed (DE) between the two groups were identified by bioinformatic analyses. Seven DE lncRNAs were validated by quantitative real-time PCR (q-PCR). The potential functions of the DE lncRNAs were predicted by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses of target genes. In addition, integrated analysis was performed for the DE lncRNAs and mRNAs to predict their interaction relationships.
A total of 232 DE lncRNAs were identified in the HFD-induced hepatic IR mice compared with the ND-fed mice. These DE lncRNAs included 108 upregulated and 124 downregulated lncRNAs, and 7 of the DE lncRNAs were validated by q-PCR. In addition, 291 DE mRNAs including 166 upregulated and 125 downregulated mRNAs were identified in the HFD group. Furthermore, target genes of the DE lncRNAs were predicted, and functional enrichment results showed that the enriched genes were involved in IR- and glycolipid metabolism-related processes. Additionally, the coexpression network was also constructed to further reflect the potential functions of the DE lncRNAs.
The study describes the expression profiles of lncRNAs and mRNAs and the functional networks involved in HFD-induced hepatic IR. These findings may provide a new perspective for the study of lncRNAs in hepatic IR- and glycolipid metabolism-related diseases.
Insulin resistance (IR) is considered to be associated with many metabolic disorders, such as type 2 diabetes and obesity. The liver is a main target organ for the action of insulin in the body. Under normal physiological conditions, insulin promotes anabolic metabolism in the liver by enhancing glucose consumption and lipid synthesis; however, the IR state is characterized by a failure to inhibit hepatic glucose production, with paradoxically increased fat accumulation, resulting in hyperglycemia and hypertriglyceridemia [1, 2]. Therefore, elucidating the pathogenic mechanism underlying hepatic IR is key to preventing and treating metabolic disorders and related diseases.
Long noncoding RNAs (lncRNAs) belong to a class of regulatory noncoding RNAs with transcript lengths greater than 200 nucleotides and serve vital roles in transcriptional and posttranscriptional gene expression regulation [3, 4]. Recently, dysregulation of lncRNAs has been found to be important in various human diseases, such as cancer, diabetes and cardiovascular diseases [5,6,7]. In particular, some reports have noted that lncRNAs play an important role in liver glycolipid metabolism. For instance, Zhu et al. showed that the expression of the lncRNA MEG3 was increased in high-fat diet (HFD)-fed and ob/ob mice and upregulated by palmitate, oleate or linoleate. The suppression of the lncRNA MEG3 improved the elevation in triglyceride levels and the impaired glucose tolerance and downregulation of the glucogen content in the HFD-fed mice or ob/ob mice [8]. However, lncRNAs specifically involved in the progression of hepatic IR are poorly characterized.
In our previous studies, hepatic IR in mice was established with HFD feeding [9]. In an attempt to understand the mechanisms underlying the lncRNAs involved in hepatic IR, in this study, systematic analyses of the hepatic expression profiles of lncRNAs and mRNAs in normal diet (ND)-fed mice and HFD-induced hepatic IR mice were performed. DE lncRNAs and mRNAs were identified in these two groups of mice. In addition, some of the DE lncRNAs were verified by quantitative real-time PCR (q-PCR). The target genes of the DE lncRNAs were also predicted, and biological functions and pathway enrichment were analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. Moreover, interaction and coexpression networks were constructed for the DE mRNAs and lncRNAs to determine the regulatory roles of lncRNAs in hepatic IR.
Ten liver tissue samples were derived from HFD-induced liver IR mice and ND-fed mice in our previous study (ND, n = 5; HFD, n = 5) [9]. Briefly, male 8-week-old C57BL/6 J mice were purchased from Vital River Laboratory Animal Technology (Beijing, China). After 1 week of adaptive feeding, mice were randomly assigned to either a ND (n = 12) group or a HFD (n = 12) group, and were fed for 12 weeks. Diet formula was showed in our previous study [9]. At the end of the 12th week of the feeding experiment, five mice randomly selected from each group were sacrificed for liver tissue collection.
RNA extraction, library construction, and high-throughput sequencing
High-throughput sequencing was performed on the liver tissue samples of each mouse individually (Majorbio Bio-Pham Technology Co., Shanghai, China). Briefly, total RNA was extracted from the liver tissue using TRIzol® Reagent (Invitrogen, Carlsbad, CA, USA), and the concentration and purity of the extracted RNA were detected by using a NanoDrop 2000 spectrophotometer (Thermo Scientific, Wilmington, DE, USA). The integrity of the isolated RNA was evaluated by agarose gel electrophoresis, and the RNA integrity number was determined with an Agilent 2100 (Agilent Technologies, Palo Alto, CA, USA). Total RNA without rRNA was utilized for RNA sample preparation using a Ribo-Zero Magnetic kit (EpiCentre Biotechnologies, Madison, WI, USA). Subsequently, RNA libraries were prepared by using the rRNA-depleted RNA with the TruSeq™ Stranded Total RNA Library Prep Kit (Illumina, San Diego, CA, USA). High-throughput sequencing was performed using the HiSeq 4000 SBS Kit (Illumina, San Diego, CA, USA).
Analysis of sequencing data
Through quality control of the raw reads produced by high-throughput sequencing, clean reads were obtained. The raw reads were processed by removing the reads with no insert clip, an N ratio exceeding 10%, sequences < 20 nucleotides (nt) and low quality. The Q20 and Q30 content of the clean data were subsequently calculated. The high-quality reads were used to analyze lncRNAs and mRNAs by mapping to a mouse reference genome with HISAT2 software [10]. The remaining reads without comment information were analyzed by StringTie novel transcript [11].
Identification of lncRNAs
Known lncRNAs were identified by comparing the transcripts of the existing reference genome and reported lncRNA sequences from a collection of lncRNA-related databases including NONCODE, Ensembl, NCBI, UCSC, LncRNAdb, GENCODE, and LncRNADisease. Novel lncRNAs were identified by filtering step by step. Preliminary filtering included removing mRNAs and selecting the transcripts with a length ≥ 200 bp, exon number ≥ 2, ORF length ≤ 300 bp and fragment count ≥3 by using gffcompare information to filter different types of lncRNAs (intergenic lncRNAs, intronic lncRNAs, and antisense lncRNAs). Advanced filters of the coding potential of lncRNAs included a Coding Potential Calculator (CPC) score < 0, a Coding-Non-Coding Index (CNCI) score < 0, a Coding Potential Assessment Tool (CPAT) result indicating low coding potential and no significance in the Pfam database.
Expression analysis of lncRNAs and mRNAs
RSEM can be used to calculate the expression of genes or transcripts from single- or double-terminal sequencing data. The quantitative expression of both lncRNAs and mRNAs in each sample was calculated in fragments per kilo-base of exon per million reads mapped. Transcripts with a P value < 0.05 and |log2 (HFD/ND)| ≥ 1 were determined to be DE genes and transcripts. A Volcano plot and hierarchical clustering were used to analyze the DE lncRNAs and mRNAs identified between ND- and HFD-fed mice.
Q-PCR
The expression of seven lncRNAs in the liver of ten mice (ND, n = 5; HFD, n = 5) was assessed using q-PCR to verify the accuracy of the high-throughput sequencing results. Total RNA was extracted from samples by using TRIzol® Reagent (Invitrogen, Carlsbad, CA, USA), and cDNA was synthesized by using the miScript II RT Kit (Qiagen, Hilden, Germany). Real-time PCR was performed with the miScript SYBR® Green PCR Kit (Qiagen, Hilden, Germany) using a 7500 FAST real-time PCR system (Applied Biosystems, Foster City, CA, USA). The relative expression of lncRNAs was calculated by the 2-△△Ct method. A two-tailed Student's t test was used to compare lncRNA expression between samples from the ND group and those from the HFD group in 3 experimental replicates. The forward and reverse primers for lncRNAs are shown in supplemental file 1. The PCR products were sequenced to verify that they had been identified correctly.
GO and KEGG enrichment analyses
The prediction of lncRNA functions is based on the functional annotations of related cis- and trans-target genes. The protein-coding genes located within 100 kb upstream or downstream of the identified DE lncRNAs were defined as cis-target genes. The RNAplex program was used to identify possible trans-target genes of the DE lncRNAs. Then, GO and KEGG enrichment analyses were performed to predict the biological functions of the DE lncRNA target genes. GO analysis was applied for the identification and annotation of genes in the three categories of molecular functions, biological processes, and cellular components. KEGG enrichment analysis was used to analyze the important pathways involving the target genes of the DE lncRNAs. The threshold (a P value ≤0.05 and false discovery rate ≤ 0.05) was calculated using Fisher's exact test.
Interaction analysis and coexpression network analysis
Interactions among the identified DE mRNAs were evaluated with Search Tool for the Retrieval of Interacting Genes/Proteins (STRING). These genes required an interaction score ≥ 0.4, and the interaction network was built with Cytoscape (version 3.6.1).
A weighted gene coexpression network (WGCNA) can be used to find clusters (modules) of highly correlated genes. The coexpression network of the DE lncRNAs and mRNAs was constructed by using the R package WGCNA. We used step-by-step network construction with a soft threshold of β = 16 (R2 = 0.43) and a minimum module size of 30. The topological overlap distance calculated from the adjacency matrix was then clustered with average linkage hierarchical clustering. The connections in each module were visualized using Cytoscape (version 3.6.1).
Sequencing data summary
In our study, libraries were constructed from liver tissue samples from ND-fed mice (n = 5) and HFD-induced hepatic IR mice (n = 5) and subjected to sequencing analysis. High-throughput sequencing produced 516,429,450 and 457,341,558 raw reads from the two groups, respectively. The raw reads were filtered to obtain high-quality clean reads. In total, 506,933,232 and 448,761,362 clean reads were retained for the ND and HFD groups, respectively (Table 1). The Q20 and Q30 of the clean data were subsequently calculated to evaluate the quality of the RNA-sequencing data. The Q20 and Q30 quality scores were higher than 90%, and the sequencing error rate was less than 1%. The data indicated that the RNA-sequencing results had reliable quality. The obtained clean reads were mapped to a mouse reference genome, with the mapping ratio ranging from 96.10 to 97.13% (supplemental file 2).
Table 1 Results of sequencing before and after quality control of ND and HFD libraries
Identification and classification of lncRNAs in the liver of mice
Based on the mouse reference genome and related databases, 10,495 known lncRNAs were found. After a strict filtering process, 541 novel lncRNAs, which exhibited repeated emergence in four software programs (CPC, PfamScan, CPAT and CNCI), were identified (supplemental file 3). According to the relative chromosomal position of the coding gene, the novel lncRNAs were classified into five broad categories: 5572 intergenic lncRNAs (50.5%), 4004 antisense lncRNAs (36.3%), 642 sense exonic overlap lncRNAs (5.8%), 22 sense intronic overlap lncRNAs (0.2%) and 796 bidirectional lncRNAs (7.2%) (Fig. 1a). Furthermore, the distributions of these lncRNAs in terms of length and chromosomal location were analyzed in this study. In different length groups, most of the lncRNAs were 201–1000 nt long (Fig. 1b). Chromosomal distribution analysis revealed that chromosomes 1, 2, 5 and Y contained relatively higher amounts of lncRNAs (Fig. 1c).
Expression characteristics of lncRNAs. a Classification of lncRNAs. b Length distribution of lncRNAs. c Chromosomal distribution of lncRNA numbers
Differential expression analysis of lncRNAs and mRNAs
After high-throughput sequencing, a total of 11,036 lncRNAs were obtained by comparing the ND and HFD groups. The analysis of the lncRNAs DE between the two groups showed that compared with the ND group, the HFD group contained 232 DE lncRNAs, among which 108 were upregulated lncRNAs and 124 were downregulated lncRNAs. Regarding the expression profiles of mRNAs, 40,675 mRNAs were present in both groups. Among all of these mRNAs, compared with the ND group, the HFD group contained 291 DE mRNAs, including 166 upregulated mRNAs and 125 downregulated mRNAs. A volcano plot and heatmap were generated to visualize the DE lncRNAs and DE mRNAs identified by comparing the two groups, as shown in Fig. 2 and in supplemental file 4. Moreover, the chromosomal distributions of the DE lncRNAs and mRNAs are shown in Fig. 3.
Volcano plots of mRNAs (left) and lncRNAs (right) differentially expressed between the two groups. Red and yellow spots represent upregulated mRNAs or lncRNAs, and blue spots indicate downregulated mRNAs or lncRNAs. Black spots represent mRNAs or lncRNAs that did not show obvious changes between the ND and HFD groups. ND, normal diet-fed mice; HFD, high-fat diet-fed mice
Distributions of differentially expressed lncRNAs and mRNAs on chromosomes. The outer layer shows the distribution on chromosomes, the middle layer indicates the differential expression of lncRNAs on the chromosomes, and the inner layer shows the distribution of differentially expressed mRNAs on the chromosomes. Red indicates upregulation, green indicates downregulation, and the height indicates the fold-change value
DE lncRNA validation by q-PCR
To validate the reliability of the lncRNA expression data, seven lncRNAs that exhibited relatively abundant expression and significant differential expression in the livers from mice in the two groups were selected and evaluated by q-PCR. These lncRNAs included one upregulated lncRNA (ENSMUST00000200707) and six downregulated lncRNAs (ENSMUST00000107095, ENSMUST00000146928, ENSMUST00000153523, MSTRG.7107.6, MSTRG.19471.1 and MSTRG.19772.3). The results showed that the level of the lncRNA ENSMUST000030200707 was significantly increased, while the levels of the lncRNAs ENSMUST00000107095, ENSMUST00000146928, ENSMUST00000153523, MSTRG.7107.6, MSTRG.19471.1 and MSTRG.19772.3 were obviously decreased in the HFD group compared with the ND group (Fig. 4). The q-PCR validation results for these DE lncRNAs were consistent with our bioinformatic analysis based on high-throughput sequencing.
q-PCR validation of seven differentially expressed lncRNAs identified using high-throughput sequencing of mouse liver tissue samples. ND, normal diet-fed mice; HFD, high-fat diet-fed mice. *P < 0.05 and **P < 0.01 compared with the value for the ND group
GO and KEGG enrichment analyses of the DE lncRNAs and mRNAs
First, target genes of the DE lncRNAs were predicted by bioinformatic approaches, and the results are presented in supplemental file 5. Subsequently, GO and KEGG enrichment analyses were performed on the predicted target genes of the DE lncRNAs. The top 30 GO terms are shown in Fig. 5a, in which "glycerol biosynthetic process from pyruvate" was majorly enriched in the biological process category. GO enrichment also indicated enrichment of other important biological processes, including various compounds and nucleic acid metabolism in the cell, mitochondrial modification, catalytic enzyme activity and molecular function regulation. Furthermore, the top 30 enriched KEGG pathways are presented in Fig. 6a, and the "Renin-angiotensin system" was the top enriched pathway. More importantly, pathway enrichment analysis showed enrichment of several pathways related to IR or glycolipid metabolism, such as the citrate cycle (TCA cycle), the PPAR signaling pathway, the AMPK signaling pathway, the MAPK signaling pathway, glycolysis/gluconeogenesis, the glucagon signaling pathway, biosynthesis of unsaturated fatty acids, the PI3K-Akt signaling pathway, insulin resistance, and the insulin signaling pathway.
The top 30 GO terms for differentially expressed genes. a The top 30 GO terms for the target genes of differentially expressed lncRNAs. b The top 30 GO terms for differentially expressed mRNAs. The circle size represents the gene number. The Q value is indicated by the color gradient
The top 30 KEGG pathways for differentially expressed genes. a The top 30 KEGG pathways for the target genes of differentially expressed lncRNAs. b The top 30 KEGG pathways for differentially expressed mRNAs. The circle size represents the gene number. The Q value is indicated by the color gradient
For the DE mRNAs, the top 30 enriched GO terms and KEGG pathways are shown in Fig. 5b and Fig. 6b. The GO terms mainly included cellular_component, biological regulation, regulation of cellular process, metabolic process, intracellular organelle and cytoplasmic part. KEGG pathway analysis showed that DE mRNAs were mainly associated with Protein digestion and absorption, Pancreatic secretion, Arachidonic acid metabolism, PPAR signaling pathway and Retinol metabolism.
Interaction and coexpression network analysis
The interactions among the proteins encoded by the DE mRNAs are shown in Fig. 7a. The Cxcl2, Serpine1 and Prss2 genes were the important genes that interacted with many of the other DE mRNAs in this network. Moreover, a DE lncRNA-mRNA coexpression network, which consisted of 87 nodes (59 DE lncRNAs and 28 DE mRNAs) and 1125 edges, was constructed (Fig. 7b). Within this RNA network, the lncRNA MSTRG.8007.2 had the maximum number of targets. The Pnlip, Ctrl, Cpb1 and Amy2a3 genes had the maximum number of coexpressed lncRNAs.
Interaction and coexpression network analyses. a Interactions between differentially expressed mRNAs. The red circle represents upregulated mRNAs, and the blue circle represents downregulated mRNAs. b Coexpression network of differentially expressed lncRNAs and mRNAs. The red arrow represents upregulated lncRNAs, the blue arrow represents downregulated lncRNAs, the blue circle represents downregulated mRNAs, the grey line represents correlation of genes, and node size represents the number of linked lines
Increasing evidence has shown that the abnormal expression of lncRNAs is closely related to the occurrence and development of IR and related diseases [8, 12, 13]. Nevertheless, a comprehensive database of the potential role of lncRNAs in the pathogenesis of hepatic IR still lacks. Therefore, in this study, using high-throughput RNA sequencing, we obtained the expression profiles of lncRNA and mRNA in the liver of ND-fed mice and HFD-induced hepatic IR mice. On this basis, we analyzed DE lncRNAs and mRNAs between the two groups and explored the potential roles of lncRNAs in progress of HFD-induced hepatic IR by various bioinformatics methods. Our results provided the valuable information for the understanding of the lncRNA function in HFD-induced hepatic IR.
In this study, after high-throughput sequencing, a total of 11,036 lncRNAs were obtained in livers of the two groups of mice. Among these lncRNAs, most of the transcripts were intergenic lncRNAs. DE lncRNA analysis showed that compared with ND mice, HFD-induced hepatic IR mice expressed 232 DE lncRNAs in the liver, including 108 upregulated lncRNAs and 124 downregulated lncRNAs. Subsequently, q-PCR was performed to validate the high-throughput sequencing results for the DE lncRNAs. Seven DE lncRNAs, which were relatively enriched in the liver and significantly DE, were subjected to experimental verification. The results showed that the expression changes in the seven lncRNAs detected by q-PCR were consistent with the sequencing results, indicating the reliability of the lncRNA sequencing data. In addition, by examining the literature, we found that the lncRNA ENSMUST00000107095 (lncRNA Gm15441), a DE lncRNA validated by q-PCR in our study, has been recently reported to be a regulator of fatty acid oxidation in hepatocytes [14]. This result further confirms the reliability and reflects the application value of our results, which provide a basis for further study of the mechanism involving lncRNAs in hepatic IR.
For the expression profiles of mRNAs, 40,675 mRNAs were present in both groups. Compared with the ND group, the HFD group exhibited 166 mRNAs with significantly upregulated expression and 125 mRNAs were significantly downregulated expression. Some of these DE mRNAs, such as Irs2 [15, 16] and Pparg [17, 18], have been shown to be closely related to the development of IR or the process of glycolipid metabolism. Moreover, the results for interactions among the DE mRNAs showed that some mRNAs, such as Cxcl2 and Serpine1, interacted with many other DE mRNAs, suggesting that they may be crucial in pathological changes that occur during HFD-induced hepatic IR and glycolipid metabolism disorder. In addition, this hypothesis has also been tested in some studies. For instance, PAI-1, which is encoded by the Serpinel gene, has been reported to exhibit elevated expression in obesity and type 2 diabetes [19, 20]. Coudriet GM et al. recently showed that the absence of PAI-1 resulted in improvements in glucose tolerance and IR [21].
The prediction of lncRNA functions is based on the functional annotation of lncRNA target genes. Thus, target genes of the DE lncRNAs were identified, and GO and KEGG enrichment analyses were applied to determine the functional distributions of these target genes. The GO functional enrichment analysis showed that the target genes associated with the DE lncRNAs were significantly involved in glycerol biosynthesis from pyruvate and various compounds and nucleic acid metabolism in the cell. It is worth noting that the target genes were significantly enriched in a variety of IR- and glycolipid metabolism-related pathways, such as the citrate cycle (TCA cycle), PPAR signaling pathway, PI3K-Akt signaling pathway and insulin signaling pathway, by the KEGG enrichment analysis. Therefore, the finding effectively suggests that these DE lncRNAs identified in HFD-induced hepatic IR mice may be involved in mediating the process of IR by regulating various signaling pathways.
Coexpression network analysis of DE lncRNAs and mRNAs is helpful for further investigating the potential functions of lncRNAs. In the network we constructed, most of the mRNAs coexpressed with the lncRNAs encoded digestive or metabolic enzymes. Some of these mRNAs have been reported to be associated with IR. For example, Nishimura et al. found that Enpp2 contributed to adipose tissue expansion and IR in diet-induced obesity [22]. Reeves et al. also reported that there is a relatively strong and consistent relationship between serum Enpp2 and glucose homeostasis or insulin sensitivity in relatively old, nondiabetic humans who were overweight or obese [23]. Thus, whether those lncRNAs coexpressed with Enpp2 are also involved in the process of IR needs to be further verified by experiments.
Furthermore, there were some limitations to this study. First, in theory, the expression levels of each DE lncRNAs in HFD-induced hepatic IR need to be validated using q-PCR, while our study only verified 7 DE lncRNAs. Thus, all DE lncRNAs in our study may only be regarded as a lncRNA reference dataset, and more further research needed to be carried out to validate the expression of lncRNAs of interest. Second, though the potential functions of the DE lncRNAs were predicted through GO and KEGG enrichment analyses of their target genes and coexpression network analysis of DE lncRNAs and mRNAs, these results lack experimental validation. Therefore, the specific lncRNAs that function in hepatic IR and their associated mechanisms should be further verified by in vivo and in vitro study in the future.
In summary, our study systematically analyzed the expression profiles of lncRNAs and mRNAs in the liver of ND-fed mice and HFD-induced hepatic IR mice, and identified DE lncRNAs and mRNAs between the two groups. The results of relevant biological functions and pathway enrichment analysis indicate that these DE lncRNAs may be involved in glycolipid metabolism and mediating the process of IR by regulating various signaling pathways. Our results provided not only a systematic perspective on lncRNAs in hepatic IR but also a valuable data resource for further study of the potential functions of lncRNAs in the pathogenesis of hepatic IR and glycolipid metabolism-related diseases.
All data generated or analyzed during this study are included in this published article (and its supplementary information files).
IR:
lncRNAs:
Long noncoding RNAs
ND:
Normal diet
HFD:
High-fat diet
Differentially expressed
q-PCR:
Quantitative real-time PCR
GO:
CPC:
Coding Potential Calculator
CNCI:
Coding-Non-Coding Index
CPAT:
Coding Potential Assessment Tool
Santoleri D, Titchenell PM. Resolving the paradox of hepatic insulin resistance. Cell Mol Gastroenterol Hepatol. 2019;7:447–56.
Méndez-Sánchez N, Chávez-Tapia NC, Zamora-Valdés D, Medina-Santillán R, Uribe M. Hepatobiliary diseases and insulin resistance. Curr Med Chem. 2007;14:1988–99.
Coe FL, Evan A, Worcester E. Kidney stone disease. J Clin Invest. 2005;115:2598–608.
Polovic M, Dittmar S, Hennemeier I, Humpf H-U, Seliger B, Fornara P, et al. Identification of a novel lncRNA induced by the nephrotoxin ochratoxin a and expressed in human renal tumor tissue. Cell Mol Life Sci. 2018;75:2241–56.
Kopp F, Mendell JT. Functional classification and experimental dissection of long noncoding RNAs. Cell. 2018;172:393–407.
Uchida S, Dimmeler S. Long noncoding RNAs in cardiovascular diseases. Circ Res. 2015;116:737–50.
Huarte M. The emerging role of lncRNAs in cancer. Nat Med. 2015;21:1253–61.
Zhu X, Wu Y-B, Zhou J, Kang D-M. Upregulation of lncRNA MEG3 promotes hepatic insulin resistance via increasing FoxO1 expression. Biochem Biophys Res Commun. 2016;469:319–25.
Zhao X, Chen Z, Zhou Z, Li Y, Wang Y, Zhou Z, et al. High-throughput sequencing of small RNAs and analysis of differentially expressed microRNAs associated with high-fat diet-induced hepatic insulin resistance in mice. Genes Nutr. 2019;14:6.
Kim D, Langmead B, Salzberg SL. HISAT: a fast spliced aligner with low memory requirements. Nat Methods. 2015;12:357–60.
Trapnell C, Roberts A, Goff L, Pertea G, Kim D, Kelley DR, et al. Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and cufflinks. Nat Protoc. 2012;7:562–78.
Yan C, Chen J, Chen N. Long noncoding RNA MALAT1 promotes hepatic steatosis and insulin resistance by increasing nuclear SREBP-1c protein stability. Sci Rep. 2016;6:22640.
Goyal N, Kesharwani D, Datta M. Lnc-ing non-coding RNAs with metabolism and diabetes: roles of lncRNAs. Cell Mol Life Sci. 2018;75:1827–37.
Batista TM, Garcia-Martin R, Cai W, Konishi M, O'Neill BT, Sakaguchi M, et al. Multi-dimensional transcriptional remodeling by physiological insulin in vivo. Cell Rep. 2019;26:3429.
Dong X, Park S, Lin X, Copps K, Yi X, White MF. Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth. J Clin Invest. 2006;116:101–14.
Honma M, Sawada S, Ueno Y, Murakami K, Yamada T, Gao J, et al. Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers. Int J Obes. 2018;42:1544–55.
Vidal-Puig A, Jimenez-Liñan M, Lowell BB, Hamann A, Hu E, Spiegelman B, et al. Regulation of PPAR gamma gene expression by nutrition and obesity in rodents. J Clin Invest. 1996;97:2553–61.
Zhang Y-L, Hernandez-Ono A, Siri P, Weisberg S, Conlon D, Graham MJ, et al. Aberrant hepatic expression of PPARgamma2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis. J Biol Chem. 2006;281:37603–15.
Shimomura I, Funahashi T, Takahashi M, Maeda K, Kotani K, Nakamura T, et al. Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity. Nat Med. 1996;2:800–3.
Juhan-Vague I, Alessi MC. PAI-1, obesity, insulin resistance and risk of cardiovascular events. Thromb Haemost. 1997;78:656–60.
Coudriet GM, Stoops J, Orr AV, Bhushan B, Koral K, Lee S, et al. A noncanonical role for plasminogen activator inhibitor type 1 in obesity-induced diabetes. Am J Pathol. 2019;189:1413–22.
Nishimura S, Nagasaki M, Okudaira S, Aoki J, Ohmori T, Ohkawa R, et al. ENPP2 contributes to adipose tissue expansion and insulin resistance in diet-induced obesity. Diabetes. 2014;63:4154–64.
Reeves VL, Trybula JS, Wills RC, Goodpaster BH, Dubé JJ, Kienesberger PC, et al. Serum Autotaxin/ENPP2 correlates with insulin resistance in older humans with obesity. Obesity (Silver Spring, Md). 2015;23:2371–6.
The research was supported by grants from the National Natural Science Foundation of China (No.81673153 and No. 81973034).
Zengyuan Zhou and Xue Zhao contributed equally to this work.
Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, Hei Longjiang province, 150081, P. R. China
Zengyuan Zhou, Xue Zhao, Liang Chen, Yuzheng Li, Zhao Chen, Yuanyuan Wang, Zihao Zhou & Xia Chu
Zengyuan Zhou
Xue Zhao
Liang Chen
Yuzheng Li
Yuanyuan Wang
Zihao Zhou
Xia Chu
XC conceived and designed the study. ZZ, XZ, YL and ZC performed experiments and wrote the manuscript. LC, YW and ZZ interpreted the data and prepared the manuscript. All authors read and approved the final manuscript.
Correspondence to Xia Chu.
All procedures described involving animals were approved by the Harbin Medical University Institutional Animal Care Committee, and conducted in accordance with the guidelines of Harbin Medical University on the experimental use of laboratory animals.
Zhou, Z., Zhao, X., Chen, L. et al. Integrated analysis of differentially expressed long noncoding RNAs and mRNAs associated with high-fat diet-induced hepatic insulin resistance in mice. Nutr Metab (Lond) 17, 45 (2020). https://doi.org/10.1186/s12986-020-00467-7
Received: 03 January 2020
Hepatic insulin resistance


* The Dawdlers are playing Silo's in Napa for the first time on Thursday, 12/28, and are really looking forward to bringing the holiday cheer to Napa (Tom'll have it in his trunk)! We want to make a splash with this one, so PLEASE SHARE THIS INFO, and if you haven't seen us in awhile, or ever, or indoors (we look even younger indoors), please come to this one, and ask your friends, neighbors, city council, bowling league, and knitting circle to come as well, as we'd like to get invited back, and consolidate Napa as another Near North Bay stronghold for the band (Eric Wood will be with us on the "skins" again that night - see below - and again there within 48 hours with Forejour!).
We hope to see a mess of you there!
* After a couple of years of helping the band besiege his hometown of Benicia, drummaster Jeff Campitelli can Dawdle no further due to time and travel constraints (the band is hoping to play more, and over a wider area in '18, and Jeff has all the gigs he could want or handle right in his backyard these days – being pretty much Benicia's official drummer at this point – besides having a busy music teaching schedule with private lessons and his work with the VOENA choir and some local schools' music dept's, not to mention parental duties).
Thanks and sincere well-wishes to Jeff and la famiglia Campitelli!
* Jim continues to sing at numerous farmers' markets over many hill and dale (see the calendar page if you'd like to combine your next carton of strawberries purchase with Jim's crooning), even in the growing chill of the season.
* AND, Jim started teaching music lessons in the fall of '16, so if you or anyone you know would like/could use some singing, guitar (bass, too), or general music instruction, please contact Jim at: lessons@jamesfunk.net.
* And, Bassey & Friends again (and also) takes the Silo's stage next Thursday night, 12/21.
Hope to see you stageside, and Happy Holidays!


The new Snapdragon 845 will be the brain of the high-end Android for 2018. Terminals such as the Galaxy S9 or the Xiaomi Mi 7 will mount the new Qualcomm chip, but they will not be the only ones.
In a deep technical session in Hawaii we have been able to better know the successor of 835. It has helped us to know a little more about the high range that we will see next year and the characteristics that we will see from the Mobile World Congress in Barcelona.
Good times come for the recording of contents in 4K, smartphones more "smart" or facial recognition.
With a quote from Kandinsky ("Color is a power that directly influences the soul"), Tim Leland from Qualcomm explained the advances that the Spectra 280, the image processor of the Snapdragon 845, incorporates.
4K HDR up to 60 fps: "The Snapdragon 845 will be the first processor capable of recording in Hollywood quality," said Tim, and referred to the chip's ability to record 4K HDR videos up to 60 fps. In addition, it will also be able to record slow motion 720p videos up to 480 fps (and 1020p at 120 fps). Definitely, with this the high-end Android will take a step in mass towards the highest quality video.
More colors and more realistic: The Spectra 280 is capable of capturing 10-bit images (instead of 8 bits as hitherto), a wider color gamut (going from the Rec 709 to Rec 2020 standard) and more brightness. Led to user experience, Qualcomm ensures that it will move in images with a wider color depth, with more color gradation, more dynamics and better quality pixels.
Bokeh without the need for a double camera: Artificial intelligence now also applies to the digital signal processor, the Hexagon 685, which translates into a phone that can apply filters in photos and videos in real time, without having to wait for the post-processing. In addition, thanks to an AI processing capability that, according to Qualcomm, is three times more powerful than that of the 835, it will not take a double camera to apply the famous bokeh or portrait effect to our photos. There will also be advances in editing with the possibility of refocusing the photo after having taken it (something that is already quite common in some high-end smartphones).
Without going too deep, they also gave us touches about technologies that will theoretically make the photos look better on the screens (thanks to the reduction of multi-frame noise), the use of algorithms to better stabilize the images and get more quality in the pixels.
As a curious detail, it was also mentioned that this new chip will cause the cameras of the new phones to exceed 100 points for the first time in the controversial DxOMark.
It is clear that Face ID has marked a path and the high-end Android will follow without doubt in 2018. The new Snapdragon 845 opens the doors to facial recognition to unlock the phone and to make mobile payments.
Do you remember the famous 30,000 Apple mapping points with your Face ID? Qualcomm raises the bar with 50,000 points of mapping in the 845, which will make it more accurate when it comes to detecting your face and, therefore, also more secure against possible replicas or attempts to deceive you.
And just in safety Qualcomm has emphasized. Sy Choudhury, senior director of architecture at the company, explained that the Snapdragon 845 will include for the first time what they have called a "secure processing unit" (SPU).
The 835 included two levels of security and this secure process unit adds one more. It is a kernel with its own memory, processor, key generator, etc. What is this for? In this "safe island", as defined by Sy, we will include our fingerprint, the mapping of our face, our Facebook password or our security code for mobile payments.
"There are different degrees of security depending on what operation you are doing," Sy added, referring to this way of separating more sensitive data and information from others.
That is, each file in that secure processing unit will be encrypted independently and isolated from the rest of the terminal information. As always in these cases, we must be cautious: it will be harder to hack, but surely not impossible.
The new X20 modem that includes the Snapdragon 845 is considered by Qualcomm as "a new step towards the 5G". They assure that it improves 20% the average speed and tip of the devices, and here already they think in speeds of more than a gigabit.
They also affirm that it will be 30% more efficient when connecting or broadcasting streaming content thanks to 11 ac Wi-Fi, which, in the same way, translates into more connection capacity for the same bandwidth.
They add that their TrueWireless technology will allow sending and receiving HD quality content via Bluetooth and with up to 50% energy savings. And here they gave us the example of bluetooth headphones. It seems that Apple's AirPods will not be alone next year.
15 minutes of charging equals a 50% charge of the terminal thanks to Quick Charge 4.
System Cache of 3MB, which reduces access to memory between 40 and 75%, which makes the terminal consume fewer resources and save more energy.
We take note of all these data because we are sure that we will see them reflected in the presentations of the high ranges of next year. Are bets accepted?


Biotechnology; Pharmacology; Microbiology; Chemical Engineering; Bioinformatics; Sports Science; Conservation; Resource Economics.
Medicine (Doctors, Nurses, Pharmacists, Laboratory Technician); Biotechnology; Chemical Engineering; Environmental Consultancy; Deities; Analytical Chemists; Research; Teaching; Lecturing and Industry - (soap, paint, sweets, beverages, etc).
Biotechnology; Pharmacology; Microbiology; Chemical Engineering; Bioinformatics; Sports Science; Conservation; Resource Economics; Medicine (Doctors, Nurses, Pharmacists, Laboratory Technician); Biotechnology; Environmental Consultancy; Deities; Analytical Chemists; Research; Teaching; Lecturing and Industry - (soap, paint, sweets, beverages, etc).
Environmental Consultancy; Teaching; Lecturing and Research.
Town Planning; Chemical Engineering; Environmental Consultancy; Analytical Chemist; Research; Teaching; Lecturing; Actuarial and Industry - (soap, paint, sweets, beverages, etc).
Software Engineer; Network Administrator; Database Administrator.
Teacher/Lecturer; Consultant; Programmer; Systems Analyst; Systems Administrator.
Background training in geography often allows one to branch into other specialized fields in the natural sciences and become a: Geologist; Cartographer; Demographer; Transport Analyst; Market Researcher; Geographic Information Specialist; Geomorphologist, Soil scientist, Meteorologist/Climatologist, Palaeontologist; Health Care Planner; Travel Agent; Industrial Planner; Land Use Consultant; Real Estate Developer; Recreation Planner; Resource Analyst; Environmental Manager; Teacher; etc.
Further studies leading to an M.Sc. in Mathematics, Engineering, Actuarial Science, Quantitative Analysis, etc.
Further studies leading to engineers, material scientists, medical doctors, medical scientists, actuarial scientists, computer and information systems, environmental scientists, government officers, etc.
This programme prepares students to design, operate, and maintain (and possibly to research in) systems such as Electrical Power and Energy; Electrical Machines; Communication Systems, Computers and Embedded Systems; Control and Instrumentation Systems; Electronic Systems and Electronic Appliances; Mechatronic Systems.


Add any kombucha products to your cart.
Enter promo code BOOCH into the promo code field on the shopping cart page.
Offer valid online and in-store through 11:59 pm CST on 4/30/2019 or while supplies last. Offer cannot be combined with any other offers, promotions or discounts.


Medicare has already become a system to be gamed. A Medicare patient went to an optometrist for new glasses, knowing that glasses are not covered under Medicare. When asked for an insurance card, she said she did not have insurance for glasses, but they wanted the Medicare card anyway.She had a rather comprehensive examination, was given a new prescription for lenses and proceeded to choose her frames and pay for her new glasses.
Several months later, she received a "Medicare Summary Notice for Part B." Medicare was billed $817.09, approved $552.07, and paid out $432.82. The patient was told that the maximum she may be billed would be $110.41, or 20 percent of the approved amount. She never received a bill.
All this for a healthy, asymptomatic patient who just needs new glasses! It is clear that Medicare has become a cash cow for enterprising "providers." This does not appear to be fraud, just creative billing for services that were not asked for and probably not needed. Medicare was willing to pay, but the self-paying patient might have been content with item No. 1 only, unless it revealed a cause for concern. And what is No. 6? An ophthalmoscope is a microscope for examining the deeper structures (see Nos. 3 and 4), and a slit lamp is a microscope for looking at the structures in front. All eye examinations by an eye doctor would routinely include these for both eyes every time.
First Published by Us in 2010, our prediction is coming close!
America on the BRINK of a CIVIL WAR between White and Black- Long before Trump took Office!
This is what the Democrat/RHINO/ Big Business Folks have given us over the last 30 years! America, will you ever wake up and stop the destruction of this nation? I fear not.
Isaiah 59:2. But your iniquities have made a separation between you and your God, And your sins have hidden His face from you so that He does not hear.
Zechariah 7:11-13. But they refused to pay attention and turned a stubborn shoulder and stopped their ears from hearing. They made their hearts like flint so that they could not hear the law and the words which the LORD of hosts had sent by His Spirit through the former prophets; therefore great wrath came from the LORD of hosts. And just as He called and they would not listen, so they called and I would not listen," says the LORD of hosts; (yes God does not LISTEN to prayer!
Jeremiah 11:11-14. Therefore thus says the LORD, "Behold I am bringing disaster on them which they will not be able to escape; though they will cry to Me, yet I will not listen to them."
So realize today, we are no better than those pagans that we read about in the Bible. We have killed millions of children through abortion, we worship a false God, and worse we arrogantly thumb our nose to God Almighty. We will pay for our sins!
The Plain Truth hurts Liberals a great deal- as well as many on the "religious" right!


"Nancy Montoya sold a patio home for Bertha Lightfoot previously. When I decided to sell my house I contacted Nancy Montoya at Century 21 in Los Lunas NM. I appreciated her to act as my realtor as I already had met her and liked her professional attitude. She not only worked with me but she also worked with my Power of Attorney Loretta to get the house sold."
"Nancy Montoya and her fantastic staff turned what could have been a nightmare for me into a smooth process. I had an offer really quickly, and Nancy & Angela & Ann Marie handled the metric ton of details needed to push the sale through to close. I would recommend Nancy Montoya to all my friends & family."
"Nancy can effectively keep the transaction moving forward and offers deep knowledge of the local area. Nancy was terrific at getting the purchase handled.
The Team adds value, too. Whenever I called, they were familiar with the details of my property purchase. I appreciate that. Thank you!"
"Excellent knowledge of the Los Lunas housing market, great support staff from initial going to market to closing. Sold house within 2 weeks, and Nancy and her staff were most handling all the closing issues that came up. Excellent work!"
"Angela Zamora was an excellent resource through the entire process. She had answers and solutions for all my questions. She helped me fulfill my dream of home ownership. Thank you!"
"We could feel we were in good hands. We got lucky with Nancy. She made our whole experience seem easy.
Thank you Nancy and Taylor!"
"It was a pleasure dealing with Nancy and her team. She is very knowledgeable with the Los Lunas area. My house was on the market only a couple of days before I got an offer. After minimal negotiation, an agreement was reached. I got a pretty fair deal and I feel the buyers did too."
"I value her experience, attention to details, service and personal touch to all of her interactions. You cannot ask for a better broker!"
"Nancy and her staff were wonderful and very familiar with our market."
"The best real estate agent we have ever worked with. Our sale was a wonderful experience."
"Very profssional, always answered her phone, or always returned calls in a timely manner. Kept us informed. Has excellent staff.
They were very nice, polite, knowledgeable, always answer their phone."
"Nancy's great, she is a friend of the community. Can confidently say that she has her act together, with great values, work ethics, and most likely has a great family.
Nancy is so easy to work with, when there was a problem, she solved it. I would not consider anyone else for the job.
When we had problems with the staff, Nancy was always there to correct and redeem Century 21 Champions.
I can not say enough great things about Nancy. Century 21, is lucky to have such a hard working representative like Nancy."
"Accurate appraisal of what property would sell for. Always accessible."
"Nancy is very professional and helped us get the best outcome on the sale of our home. We look forward to using her again in the future!"
"Nancy Montoya is the best"
"Our agent, Maan, knows what I look for in real estate...she always has her eyes open for potential sales which fit my specifications. Nancy ensures that everything moves along without delay. I will never use another agent/ broker....I have found the best."
"Nancy does an excellent job."
"Nancy is the BEST!!!! Really knows Valencia county!!!!!"
"Nancy is very knoledgable and is willing to work very hard to assist with any needs. I really enjoyed working with Nancy. Thank you Navy for making our dream come true."
"Good job selling our house."
"Nancy Montoya took a personal approach with our 86yr old mother, the seller, and did an excellent job explaining each step and what was expected. We had 3 buyers within a week which indicates that the selling price was right on. We were impressed that she took our mother's listing considering the large properties Nancy Montoya has listed. She treated us as if we were one of the big properties."
"Honest, trustworthy, gets the job done, You can count on Nancy. She will find answers and solutions to your questions and concerns. I'll definitely use her again.
Nancy's assistant was also very helpful.
"Nancy is the only competent broker in Los Lunas."
"I have used Nancy Montoya for 2 property purchases and 2 property sales and I wouldn't consider using anyone else. Her real estate signs are everywhere indicating to me that many other property owners wishing to sell their real estate feel the same way as I do.
Nancy Montoya handled every aspect of the sale. All I did was show up at the closing which went smoothly.
Nancy Montoya is professional in every way.
Nancy Montoya was able to sell my house for my asking price by suggesting a financial arrangement that the buyer was able to use."
"I would recommend Nancy to all my friends"
"in my own words.nancy Montoya is a very nice and polite person. yes I would recommend her in selling anyones home or first time home buyer that's my honest answer."
"Nancy is amazing. She really listened to our needs and was so helpful through the process."
"Nancy was professional and worked very hard to sell my house. I would use her again to sell a property. I would also recommend her to family and friends."
"Nancy went well beyond what one generally expects of a broker. Since I live in another state, Nancy was willing to make arrangements with local service providers to get the house ready for resell. She made herself available at my convenience and was always professional and friendly."
"Nancy helped us all the way through the buying process and closing and did it across country. Couldn't have done better."
"I repay liked how Namcy tried her hardest to get things done. She was on top of it, very respectful, and had great communication. Thank you!"
"Nancy was a pleasure to work with. Would seek her experience in the future, if needed."
"Every phase of the sale was handled professionally and helpfully. The sale of my house sold very quickly in spite of a depressed local housing market. I was quite pleased with Nancy Montoya and Century 21."
"I was thrilled with every aspect of working with Nancy (and the rest of her team). It was my first time selling a home and I was intimidated by the process and had talked to a couple of other agents that did not feel right. Nancy immediately made it easy and even enjoyable. She was always accessible, generous and flexible with her time. I wouldn't consider anyone else the next time I need to buy or sell a home and will be quick to recommend her."
"Nancy Montoya was wonderful to work with from the beginning to the end of our real estate purchase with her. Nancy worked extremely hard in making this transaction happen for my husband and myself. I would not hesitate for a moment to use her again in the future for other real estate properties. Thank you Nancy for your time, efforts and love you put into making a piece of property that means a lot to me a reality.
"Nancy took time to understand the circumstances of our situation and tailored our marketing plan to meet our needs. She was always looking out for us...especially during a very difficult closing."
"Nancy Montoya did not give up on the sale of my home or the process. She got it done and it was a very difficult sale with many obstacles."
"I was scared at first not knowing what to expect from the sale of our first home . Nancy was so easy to talk to . She understood what we wanted to accomplish and went above and beyond to help us achieve our desired goal . I will always be great full to her . I will never recommend anyone else for realtor services . She has earned a customer and a recommendation for life !"
"Nancy Montoya made the sale of my unusual house happen and at my asking price."
"Nancy and her crew did an amazing job! This is our first home and they were nothing but helpful through the whole process!"
"She handled the sale very professionally"
"Everthing from Maan and Nancy at Century 21 was great! We would definitely use them again."
"Nancy's assistant Teresa Maestas i have worked with before and fully trust her to work hard be honest and go above and beyond."
"We really appreciate everything Nancy did for us all of her try and patients! She is an awesome realtor and we would definitely use her again."


Southwest Iowa Transit Agency (SWITA), which operates the public transit system in our eight county region.
Southwest Iowa Housing Trust Fund (SWIHTF), which provides safe, affordable housing and expands housing opportunities in the region.
RPA 13 provides technical assistance and transportation planning in a four county area.
Multiple types of planning and technical assistance are available to our cities and counties including writing plans, grant applications, project management, codes and ordinances, etc.
SWIPCO is also the designated economic development area for a six county region and provides funding assistance to new and existing businesses through our Business Revolving Loan Fund.
Explore the menus to see what SWIPCO can do for you and your local government.
Southwest Iowa Planning Council (SWIPCO) Board of Directors Meetings are open to all individuals regardless of disability. Any person with a disability requiring a reasonable accommodation to participate in a Board of Directors Meeting should contact the SWIPCO office at 712-243-4196 at least two business days prior to the Board of Directors meeting.


text:
Sitemap | Legal | Subscribe to RSS
ROADHOUSE TV
CONFERENCE ALBUMS
Saturn Metals Extends Apollo Hill Mineralisation
December 11, 2019 /in Resources Roadhouse, The Drill Sergeant /by Wally Graham
THE DRILL SERGEANT: Saturn Metals (ASX: STN) released results from a reverse circulation (RC) drilling program recently completed at the company's 100 per cent-owned Apollo Hill gold project in the Western Australian goldfields.
Saturn Metals completed the Apollo Hill program as part of its efforts to rapidly expand the newly discovered high-grade hanging wall zones and to grow the project's recently upgraded 781,000 ounce Mineral Resource.
The company claimed the drilling successfully extended mineralisation in multiple directions.
Results include:
AHRC0297
5 metres at 4.7 grams per tonne gold from 126m;
6m at 4.08g/t gold from 108m within 55m at 0.62g/t gold from 92m;
14m at 1.4g/t gold from 133m;
14m at 1.21g/t gold from 12m within 28m at 0.9g/t gold;
8m at 1.7g/t gold from 33m within 21m at 0.72g/t gold from 33m;
6m at 2.2g/t gold from 129m within 19m at 0.91g/t gold from 116m;
"Results continue to show the potential for significant resource growth immediately adjacent to Apollo Hill in the higher-grade hanging-wall zones, while a widening mineralised corridor may provide multiple opportunities for additional discovery," Saturn Metals managing director Ian Bamborough said in the company's announcement to the Australian Securities Exchange.
"Improving mineralisation in other areas such as the Ra area is a bonus.
"Importantly, we look forward to results from our recently completed deeper step out holes which have been drilled to test for mineralisation down dip of both the northern and southern higher-grade hanging-wall zones.
"A second 10,000 metre extensional RC phase is planned to commence in early January 2020."
Email: info@saturnmetals.com.au
Web: www.saturnmetals.com.au
https://resourcesroadhouse.com.au/wp-content/uploads/2017/06/logo-finalized4.png 0 0 Wally Graham https://resourcesroadhouse.com.au/wp-content/uploads/2017/06/logo-finalized4.png Wally Graham2019-12-11 09:55:562019-12-11 09:56:09Saturn Metals Extends Apollo Hill Mineralisation
Saturn Metals Continues Drilling at Apollo Hill
November 15, 2019 /in Resources Roadhouse, The Drill Sergeant /by Wally Graham
THE DRILL SERGEANT: Saturn Metals (ASX: STN) released new results from a reverse circulation (RC) drilling program underway at the company's 100 per cent-owned Apollo Hill gold project in the Goldfields region of Western Australia.
Saturn Metals is currently drilling up to 13,000 metres at Apollo Hill as it looks to rapidly expand the newly discovered high-grade hanging wall zones and to grow the project's recently upgraded 781,000 ounce Mineral Resource.
The company said the drilling is focussed on extending mineralisation with results from exploration step-outs to the east and down dip including:
5 metres at 5.19 grams per tonne gold from 44m within 16m at 1.69g/t gold from 44m;
11m at 1.2g/t gold from 180m within 25m at 0.61g/t gold from 166m; and
7m at 2.13g/t gold from 64m.
Saturn explained the results from AHRC0269 (5m at 5.19g/t gold from 44m) have identified a new gold lode to the north-east of Apollo Hill, outside the existing resource that was completed in October 2019.
The results achieved in AHRC0244 (11m at 1.2g/t gold from 180m) have highlighted the continuity of the hanging wall lodes down dip, 80m below the current hanging wall resource, and adjacent to the main lode.
At this stage the drilling remains open while intersections continue to improve the ratio of mineralised material to non-mineralised material in the Resource area.
Assays are pending for a further 28 holes that have been drilled to date.
"Results continue to confirm our thesis for step change growth immediately adjacent to the Apollo Hill main lode," Saturn Metals managing director Ian Bamborough said in the company's announcement to the Australian Securities Exchange.
"We are extremely encouraged by the widening gold system, further higher-grade intersections, and the extension of the hanging wall system down dip.
"We are pressing ahead with our accelerated exploration effort as our confidence in the geological picture and gold system grows."
https://resourcesroadhouse.com.au/wp-content/uploads/2017/06/logo-finalized4.png 0 0 Wally Graham https://resourcesroadhouse.com.au/wp-content/uploads/2017/06/logo-finalized4.png Wally Graham2019-11-15 09:17:312019-11-15 09:17:31Saturn Metals Continues Drilling at Apollo Hill
THE DAILY ROADHOUSE
October 14, 2019 /in Resources Roadhouse /by Wally Graham
Stavely Minerals Undertaking $19.6 Million Raising
THE BOURSE WHISPERER: Stavely Minerals (ASX: SVY) is conducting a capital raising of $19.6 million by way of a share placement of 19.6 million shares at $1.00 per share.
Saturn Metals Upgrades Apollo Hill Gold Resource
THE DRILL SERGEANT: Saturn Metals (ASX: STN) has completed an updated Mineral Resource estimate for the Apollo Hill gold deposit at the company's 100 per cent-owned Apollo Hill gold project near Leonora in the Western Australian Goldfields.
Meteoric Resources Continues Juruena Golden Run
THE DRILL SERGEANT: Meteoric Resources (ASX: MEI) announced the latest batch of assays from the company's 100 per cent-owned Juruena gold project in Brazil.
Auroch Minerals Progresses Saints Nickel Project Drill Program
THE DRILL SERGEANT: Auroch Minerals (ASX: AOU) kept the market up to date on the progress of its maiden drilling program underway at the company's recently-acquired Saints nickel project near Kalgoorlie in Western Australia.
Independence Group Teams up with Apollo Consolidated at Louisa Nickel Sulphide Project
THE BOURSE WHISPERER: Independence Group (ASX: IGO) has entered a farm-in and joint venture with Apollo Consolidated Limited (ASX: AOP).
https://resourcesroadhouse.com.au/wp-content/uploads/2017/06/logo-finalized4.png 0 0 Wally Graham https://resourcesroadhouse.com.au/wp-content/uploads/2017/06/logo-finalized4.png Wally Graham2019-10-14 11:17:022019-10-14 11:19:04THE DAILY ROADHOUSE
October 14, 2019 /in Resources Roadhouse, The Drill Sergeant /by Wally Graham
The upgraded Mineral Resource totals 24.5 million tonnes at 1 gram per tonne gold for 781,000 ounces of gold.
Saturn Metals highlighted the increase in contained ounces from its previously published resource as it incorporates the results of a 152-hole, 18,600m extensional and in-fill drilling campaign completed since the last Mineral Resource upgrade published in mid-November 2018.
The updated Resource contains an addition of 96,000 ounces of gold from the previous Inferred and Indicated Mineral Resource.
Based on the additional drilling, a total of 9.2 million tonnes at 1g/t gold for 298,000 ounces is now classified as an Indicated Mineral Resource representing 38 per cent of the total Mineral Resource and a 250 per cent increase from the previous Indicated Mineral Resource.
Saturn Metals has now added 276,000 ounces to the Apollo Hill Mineral Resource in approximately 18 months with 28,000m of RC and diamond drilling.
"This resource upgrade is another significant step for the company and the Apollo Hill asset only a short while since listing," Saturn Metals managing director Ian Bamborough said in the company's announcement to the Australian Securities Exchange.
"Improvements in localised grade, ounces, tonnes, quality and Mineral Resource categories, all with efficient drilling and at an effective discovery cost per ounce, bode well for the development of our business.
"With some of the strongest intersections located in the newly discovered higher-grade hanging-walls, the system is wide open for rapid expansion.
"Drilling has already resumed to test these and other step out targets and results from this expansionary phase of our journey will be reported in due course."
Resource additions since Saturn listed on the ASX in March 2018 have been made at a rate of 9.8 gold ounces for every metre drilled and modelled.
The company's strategy moving forward is to target further expansion of the Apollo Hill gold deposit and look for new deposits across its regional land package before initiating a scoping study.
https://resourcesroadhouse.com.au/wp-content/uploads/2017/06/logo-finalized4.png 0 0 Wally Graham https://resourcesroadhouse.com.au/wp-content/uploads/2017/06/logo-finalized4.png Wally Graham2019-10-14 10:09:192019-10-14 10:09:19Saturn Metals Upgrades Apollo Hill Gold Resource
Saturn Metals Drilling Encouraging Results at Apollo Hill
August 7, 2019 /in On The Air, Resources Roadhouse, The Conference Caller /by Wally Graham
THE CONFERENCE CALLER: Saturn Metals (ASX: STN) has had a stellar 12 months since we last caught up with the company at last year's Diggers & Dealers Conference.
Saturn Metals recently announced it had encountered additional strong drill results from a RC drilling campaign currently underway at the company's 100 per cent-owned Apollo Hill gold project near Leonora in the Western Australian goldfields.
The company's interpretation of the drilling has shown geology and assays outlining several hanging-wall splays defined over 800 metres of strike length.
The system is open at depth, down plunge and along strike.
Saturn Metals managing director Ian Bamborough sat down with the Resources Roadhouse at the 2019 Diggers & Dealers Mining Forum in Kalgooorlie to expand on the recent drilling and to provide some insight into what's next.
https://resourcesroadhouse.com.au/wp-content/uploads/2019/08/Saturn-Metals-front-page_Fotor-300x300.jpg 300 300 Wally Graham https://resourcesroadhouse.com.au/wp-content/uploads/2017/06/logo-finalized4.png Wally Graham2019-08-07 09:33:292019-08-07 10:40:16Saturn Metals Drilling Encouraging Results at Apollo Hill
Saturn Metals Makes Strong Gold Intersections at Apollo Hill
April 29, 2019 /in Resources Roadhouse, The Drill Sergeant /by Wally Graham
THE DRILL SERGEANT: Saturn Metals (ASX: STN) announced drill results from holes 14 to 24 of a planned 48-hole, RC and diamond drilling campaign underway at the company's 100 per cent-owned Apollo Hill gold project, near Leonora in the Western Australian goldfields.
26 metres at 1.19 grams per tonne gold from 1m, including 10m at 2.1g/t gold from 8m; and
AHRC135
22m at 1.5g/t gold from 128m, including 12m at 2.33g/t gold from 128m.
Saturn Metals said the results would help it define a continuous higher grade (+2g/t gold) lode on the footwall side of the Apollo Hill Resource envelope.
"These excellent results will be a great addition to our next resource update planned for the second half of 2019," Saturn Metals managing director Ian Bamborough said in the company's announcement to the Australian Securities Exchange.
"It is great to see the continuity of improved grade within the current resource envelope.
"In addition, further strong intersections such as AHRC0127 returning 6 metres at 5.21 grams per tonne gold from 37m in the hanging wall zone, continue to give us cause for excitement."
Saturn Indicated it was planning to complete another 5,000 metres of drilling at Apollo Hill in the coming months.
Assay results from the ongoing drilling program will be reported as received.
Website: www.saturnmetals.com.au
https://resourcesroadhouse.com.au/wp-content/uploads/2017/06/logo-finalized4.png 0 0 Wally Graham https://resourcesroadhouse.com.au/wp-content/uploads/2017/06/logo-finalized4.png Wally Graham2019-04-29 14:25:302019-04-29 14:25:30Saturn Metals Makes Strong Gold Intersections at Apollo Hill
Saturn Metals Resumes Apollo Hill Resource Drilling
February 14, 2019 /in Resources Roadhouse, The Drill Sergeant /by Wally Graham
THE DRILL SERGEANT: Saturn Metals (ASX: STN) is back out on the ground having resumed resource extension and infill drilling at the company's 100 per cent-owned Apollo Hill gold project, near Leonora in the Western Australian goldfields.
Saturn Metals is undertaking a new program of up to 3,600 metres of reverse circulation (RC) drilling at Apollo Hill as it looks to rapidly grow the project's Mineral Resource, which currently stands at 20.7 million tonnes grading 1 gram per tonne gold for 685,000 ounces.
This round of drilling follows broad-spaced step-out drilling the company carried out last year that confirmed the continuation of the Apollo Hill system, to the north and south.
The company explained the new program will seek to infill these corridors of mineralisation.
"Significant potential exists to find higher grade zones between the step-out intersections reported in December last year and the northern and southern ends of the current Apollo Hill resource envelope," Saturn Metals managing director Ian Bamborough said in the company's announcement to the Australian Securities Exchange.
"That is what particularly excites us about this new program."
Saturn indicated it would provide further information from the resource extension drilling and the regional aircore program that is taking place concurrently at Apollo Hill as results are received and analysed.
https://resourcesroadhouse.com.au/wp-content/uploads/2017/06/logo-finalized4.png 0 0 Wally Graham https://resourcesroadhouse.com.au/wp-content/uploads/2017/06/logo-finalized4.png Wally Graham2019-02-14 10:39:392019-02-14 10:39:39Saturn Metals Resumes Apollo Hill Resource Drilling
Saturn Metals Increases Apollo Hill Resource
THE DRILL SERGEANT: Saturn Metals (ASX: STN) completed an updated Mineral Resource estimate for the Apollo Hill gold deposit, part of the company's 100 per cent-owned Apollo Hill gold project near Leonora in the Western Australian Goldfields.
Sturn Metals' upgraded Mineral Resource for Apollo Hill totals 20.7 million tonnes at 1 gram per tonne gold for 685,000 ounces.
This represents a 36 per cent increase in contained ounces from the company's previously published resource.
The new Resource incorporates the results of a 72-hole extensional and in-fill drilling campaign Saturn Metals completed earlier this year.
The company said it already has drilling in progress to further test the extents of the Apollo Hill gold system, adding that the drilling to date on the six-kilometre Apollo Hill trend is only a small part of the exploration potential on Saturn's underexplored 1,000 square kilometre, 100 per cent-owned contiguous tenement package.
"This resource upgrade is a significant step for the company and the Apollo Hill asset only a short while after listing," Saturn Metals managing director Ian Bamborough said in the company's announcement to the Australian Securities Exchange.
"Improvements in grade, ounces, tonnes, quality and JORC Code category, all with minimal drilling and at a low discovery cost per ounce, bode well for the development of our business.
"With some of the strongest intersections located at both the northern and southern extent of the deposit, the system is wide open for rapid expansion.
"Drilling has already resumed to test these targets and results from this expansionary phase of our journey will be reported in due course."
https://resourcesroadhouse.com.au/wp-content/uploads/2017/06/logo-finalized4.png 0 0 Wally Graham https://resourcesroadhouse.com.au/wp-content/uploads/2017/06/logo-finalized4.png Wally Graham2018-11-21 08:42:232018-11-21 08:42:23Saturn Metals Increases Apollo Hill Resource
Saturn Metals Drilling at Apollo Hill
THE DRILL SERGEANT: Saturn Metals (ASX: STN) announced the commencement of a new phase of exploratory RC drilling at the company's wholly owned Apollo Hill gold project, near Leonora in the Western Australian goldfields.
Saturn Metals has completed earlier drilling at the project, from which it has determined it to be a major gold and alteration system wide open for expansion
Recent drilling results from the northern end of Apollo Hill, include:
10 metres at 2.98 grams per tonne gold from 92m within 28m at 1.2g/t gold from 82m.
At the southern end of the deposit drilling encountered:
58m at 1.06g/t gold from 65m, including 36m at 1.39g/t gold from 87m.
Saturn Metals commenced drilling earlier this week with the intent of completing approximately 20 holes for approximately 2,500 metres in its search for additional opportunities to expand the deposit's footprint.
The planned drilling will step out along a six-kilometre-long anomalous gold corridor and provide an initial test of the area between the Apollo and Ra zones testing multiple interpreted structures and targets.
"This program of drilling is in keeping with Saturn's objective of growing the Apollo Hill gold system as rapidly as possible," Saturn Metals managing director Ian Bamborough said in the company's announcement to the Australian Securities Exchange.
"We have been looking forward to testing these more expansionary targets for some time and we are hopeful the results will demonstrate the greater potential at Apollo Hill.
"Our confidence in the system continues to grow."
Saturn Metals said it anticipates announcing an update to the Apollo Hill resource in the coming weeks utilising drilling results from a drilling program completed in July that highlighted the potential to increase the scale of the known mineralised system from the current 0.5 million-ounce JORC 2012-compliant inferred gold resource of 17.2 million tonnes at 0.9 grams per tonne gold.
https://resourcesroadhouse.com.au/wp-content/uploads/2017/06/logo-finalized4.png 0 0 Wally Graham https://resourcesroadhouse.com.au/wp-content/uploads/2017/06/logo-finalized4.png Wally Graham2018-10-30 10:57:092018-10-30 10:57:09Saturn Metals Drilling at Apollo Hill
Saturn Metals Completes Apollo Hill Resource Expansion Drilling
September 13, 2018 /in Resources Roadhouse, The Drill Sergeant /by Wally Graham
THE DRILL SERGEANT: Saturn Metals (ASX: STN) reported further results from infill and extensional resource drilling at the company's 100 per cent-owned Apollo Hill gold project, near Leonora in the Western Australian goldfields.
Saturn Metals said the latest drilling had further extended several thick and higher-grade zones of mineralisation towards the surface within the main Apollo Hill resource area.
Highlights of the recent Apollo Hill resource drilling include:
23m at 1.76 grams per tonne gold from 124m, including 17m at 2.32g/t gold from 130m;
46m at 1.11g/t gold from 19m, including 10m at 1.85g/t gold from 25m, and 7m at 2.5g/t gold from 58m;
22m at 1.08g/t gold from 74m, including 12m at 1.72g/t gold from 78m;
10m at 2.39g/t gold from 61m;
22m at 1.02g/t gold from 62m; and
32m at 1g/t gold from 127m, including 20m at 1.46g/t gold from 127m;
Saturn Metals explained these results will be the last to be received from the infill and extensional resource drilling program that was commenced just after the company listed on the ASX in March 2018.
They will be incorporated with all other results from the program and utilised in the Resource recalculation Saturn is currently undertaking and expects to complete later this year.
"The reported intersections have improved the mineral inventory in the heart of the Apollo Hill Resource area," Saturn Metals managing director Ian Bamborough said in the company's announcement to the Australian Securities Exchange.
"These results, when coupled with other impressive extensional results reported during August, further demonstrate the capacity to improve the development potential of this major gold system.
"Having reported all outstanding results, we are now in the process of incorporating them into a new resource estimate, which we expect to release in the December quarter."
https://resourcesroadhouse.com.au/wp-content/uploads/2017/06/logo-finalized4.png 0 0 Wally Graham https://resourcesroadhouse.com.au/wp-content/uploads/2017/06/logo-finalized4.png Wally Graham2018-09-13 08:33:222018-09-13 08:33:22Saturn Metals Completes Apollo Hill Resource Expansion Drilling
whitespace ko
ASX ANNOUNCEMENTS THIS WEEK
VERTICAL EVENTS
CONFERENCE DAILIES
FRIENDS OF THE ROADHOUSE
121 Mining Investment 5-6 February 2018 - Cape Town
121 Mining Investment Hong Kong - Spring Edition 24-25 April 2018 Grand Hyatt Hong Kong.
121 Mining Investment London - Spring Edition May 2018 - Etc. venues, County Hall, London
121 Mining Investment New York - Spring Edition 5-6 June 2018 - Westin Grand Central, NYC
121 Mining Investment London - Autumn Edition 29-30 October 2018 - Etc. venues 8 Fenchurch Place, The City of London
Silver Lake and Integra intergration
Corazon maintains nickel focus
Ventnor strengthening
One Off The Wood
ROADHOUSE REGULARS
© 2020 Resources Roadhouse Pty Ltd ABN: 87 631 738 602 - Contact - Legal - Sitemap - Delivered with


text:
The Société des gens de lettres de France (SGDLF; ; ) is a writers' association founded in 1838 by the notable French authors Honoré de Balzac, Victor Hugo, Alexandre Dumas, and George Sand.

It is a private association recognised in France as an establishment in the public interest by decree of 10 December 1891.

Members of the society must be writers whose work has been published by a publishing house (self-published works do not qualify). It is directed by a volunteer committee consisting of twenty-four writers, and is currently led by the novelist Alain Absire.

Purpose
It is the only writer-run writers' association in France with the expressed aim of defending the moral rights, the legal interests, and the social and legal status of all writers. It protects, considers, and proposes new rules and arrangements for the benefit of the community of writers.

The SGDLF offers social and legal assistance to its members. It has facilities for the deposit of completed works, helping writers guarantee their rights as original author in case of a legal dispute. Each year it organises diverse cultural events and awards a number of €75,000 prizes in recognition of published works.

Headquarters
The SGDLF occupies the 18th-century neoclassical Hôtel de Massa on rue de Faubourg-Saint-Jacques in the  14th arrondissement of Paris.  It is building with the strange history of having been moved stone by stone in 1928, from its original site on the Champs-Élysées to its present site in the garden of the Observatoire de Paris.

Prizes of the Société des gens de lettres

Spring session
Prizes recognising the entire oeuvre of an author
Grand prix de littérature de la SGDL, founded in 1947
Grand prix de poésie de la SGDL, founded in 1983
Prix Paul Féval de littérature populaire, founded in 1984
Prizes recognising a single work
Grand Prix SGDL du roman,  founded in 1947
Grand Prix SGDL de la nouvelle,  founded in 1984
Grand Prix SGDL du livre d'Histoire / Essai,  founded in 1986
Grand Prix SGDL du livre Jeunesse,  founded in 1982
Prix de poésie Charles Vildrac,  founded in 1973
Grand Prix SGDL de l'œuvre Multimédia

Fall session
Prizes recognising the entire oeuvre of an author
Grand Prix Poncetton de la SGDL, founded in 1970
Prix de Poésie Louis Montalte, founded in 1992
Prizes recognising a single work
Grand Prix Thyde Monnier de la SGDL, founded in 1975
Bourses Thyde Monnier, since 1975
Bourses Poncetton
Prizes for translation
Prix Halpérine-Kaminsky Consécration, since 1993
Prix Halpérine-Kaminsky Découverte, since 1993
Prix Gérard de Nerval
Prix Baudelaire
Prix Maurice-Edgar Coindreau

See also

 French literature
 Academy
 Encyclopédistes

External links
 —SGDL−Société des gens de lettres website

French writers' organizations
Gens de lettres
French literature
French literary awards
Arts organizations based in France
Learned societies of France
Organizations based in Paris
Organizations established in 1838
1838 establishments in France
14th arrondissement of Paris

redpajama_set_name: RedPajamaWikipedia