text:
#Region "License"

' The MIT License (MIT)
'
' Copyright (c) 2018 Richard L King (TradeWright Software Systems)
'
' Permission is hereby granted, free of charge, to any person obtaining a copy
' of this software and associated documentation files (the "Software"), to deal
' in the Software without restriction, including without limitation the rights
' to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
' copies of the Software, and to permit persons to whom the Software is
' furnished to do so, subject to the following conditions:
'
' The above copyright notice and this permission notice shall be included in all
' copies or substantial portions of the Software.
'
' THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
' IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
' FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
' AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
' LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
' OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
' SOFTWARE.

#End Region

Public Class PositionMultiEventArgs
    Inherits AbstractEventArgsWithTimestamp
    Public Property Account As String

    Public Property AverageCost As Double?

    Public Property Contract As Contract

    Public Property ModelCode As String

    Public Property Position As Double?

    Public Property ReqId As Integer

    Public Sub New(timestamp As DateTime, reqId As Integer, account As String, modelCode As String, contract As TradeWright.IBAPI.Contract, pos As Double?, avgCost As Double?)
        MyBase.New()
        Me._Timestamp = timestamp
        Me.ReqId = reqId
        Me.Account = account
        Me.ModelCode = modelCode
        Me.Contract = contract
        Me.Position = pos
        Me.AverageCost = avgCost
    End Sub
End Class


We also focus on developing moral authority as a means to inspire.
What qualifies us to offer our programs?
What qualifies us to offer our programs is our own practical national and international real-life experiences over many years in leadership and in representing leaders around the world.
Specifically, we rely on the leadership experience of our founder, Michael Friedlander, who has not only worked around the world with prominent leaders for over 30 years, he has also been the CEO of several international businesses.
Storytelling is a remarkable teaching tool. It is also as a powerful tool to transmit ideas and values – and to stimulate thought and motivate those around us. This is why our programs focus on storytelling.


Horse ride to picnic spot by riverside. Hot lunch and fishing. In the afternoon visit to Paro town.
Day trip to Thimpu,CapitalCityofBhutan, Sightseeing to Thimpu town.
In the morning, drive to Phuentsholing and leisure /ParoAirportfor departure- Tour Concludes.


Android turns 10. Ten years ago this week, Larry Page and Sergey Brin rollerbladed into a press conference where T-Mobile, HTC, and Google announced the world's first Android phone.
However, before the G1, codenamed Dreamer, there was another reference device that Google used to develop the operating system: Sooner. Lacking a touchscreen, Sooner was based on an existing device, the HTC EXCA 300, according to Steven Troughton-Smith. Its 320×240 LCD is powered by a TI OMAP850 processor with 64MB of RAM. On its premiere, Android was particularly rough around the edges. By default, it couldn't play video outside of YouTube. Android Market, the precursor to Google Play, had just a handful of apps. There wasn't even a virtual keyboard.
Dreamer, what became the G1, was considered the "risky/long-term device" and was ultimately what Android launched on.
Android 1.0 was officially unveiled on September 23, 2008. Over the past decade, Android has grown by leaps and bounds, with a new upgrade every year. The current version is 9.0 Pie, which was released in August 2018. A decade later, the landscape has significantly changed with the smartphone dominant and democratized. Today, the OS takes a whopping 88% of the market share while Apple holding 11.9% of the pie. Evidently, the open nature of the OS and the wide availability of low-end to top-tier devices won over many fans' hearts over the years shaping up Android as we know it.
As of 2017, more than 2 billion devices across the globe run on Android. And from Android Market, which had a handful of apps, Google Play today has millions of apps spanning across categories. Android now works on platforms beyond just smartphones. Google has developed the OS for televisions, for smartwatches, smart home devices, VR Headsets and has even developed Android Auto for cars. As per reports, some variants of Android OS is also in game consoles and Digital Cameras and PCs and other Electronics.


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Shanghai Zenith provide you reasonable stone crusher machine price. .... 2. what is your raw material plan to process? like lizenithne, granite or inron ore, etc. 3. ... used stone crusher machine, used st. ... Zenith stone crusher in nigeria, st.


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The former home of 25N Coworking in Geneva, a Chicago suburb. The company recently moved into a larger space to meet rising demand. Courtesy of 25N Coworking
Why Co-Working Is Moving to the Suburbs
Shared work spaces are popping up far away from urban cores.
When Anju Kurian works, she fires up her computer at Serendipity Labs, a co-working space in Rye, a Westchester County suburb of New York City. "Work is everywhere," says Kurian, the co-founder of Vermilion Talent, a business that helps women reenter the workforce after leaving corporate life to raise their children.
For many, the word "co-working" still conjures up images of skinny-jeans-clad, cold-press-swilling tech types in a downtown warehouse. But the practice has grown by leaps and bounds in a short period of time. According to a study by the magazine Deskmag, the number of co-working spaces worldwide is expected to increase by 22 percent in 2017. And as it has grown, co-working has spread to the suburbs.
What's next in workforce development
Serendipity Labs is one of several co-working companies found outside of urban cores. "Work locations and the workforce of today are neither urban or suburban, but an interwoven blend depending both on clients and where employees live," says John Arenas, Serendipity Labs' CEO.
Five of the company's six current locations (it has more in development) are in suburban places like Aventura, Florida, and Ridgewood, New Jersey. All are near transportation hubs or major interstate arteries, which makes traveling to an urban HQ easy. This is a key advantage for large corporate clients, whose workers often need both urban and suburban sites to work.
Serendipity and its competitors, such as New York City-based WeWork (which doesn't have any suburban locations yet), offer corporations the security, ergonomics, and legal compliance they require for remote employees. Now, nearly 45 percent of Serendipity's members are not entrepreneurs but remote employees of established companies.
Serendipity Labs has 1,900 square feet in this building in Bethesda, Maryland. (Courtesy of Serendipity Labs)
For example, Robert Meier, a senior sales executive at the Albany, New York-headquartered SmartWatt Energy, an energy-efficiency firm with 18 offices nationwide, did not want to relocate his family from Westchester to Albany. So SmartWatt covers his dedicated desk and secure phone line at Serendipity's Rye location.
"What's happening now is the unbundling of work," says Sam Rosen, co-founder of Deskpass, a co-working subscription service providing access to 70 workplaces in the Chicago, Los Angeles, and Denver areas, including in suburbs like Pasadena, California, and Naperville, Illinois. "Work is a thing you do, and that's separate from where you do it."
While suburban co-working spaces are a boon to corporations that need space for a satellite office or a mobile team, they may also be more diverse in terms of industry, age, and gender than their urban counterparts. Serendipity boasts that more than 40 percent of its members are women, double the national industry average.
Mara Hauser, the CEO of 25N Coworking, a standalone co-working space in Geneva, Illinois, just west of Chicago, says more than half of her members are women. Many of them—especially those with young children—prefer to work near their homes, which are often in the suburbs, she says.
"We are close to home, school, activities, everything."
"We are close to home, school, activities, everything," she says. "People who work here, whether they are corporate members or entrepreneurs, want the flexibility of going home in the middle of the day if they need to."
Likewise, Kurian says her clients find co-working spaces in their neighborhoods to be a great waypoint on their path back to corporate life. "They work here [in Serendipidy Labs] first, get focused outside of home, and make connections," she says. "There has been a lot of synergy between our clients and the corporate workers here."
Arenas believes that co-working will become part of work culture everywhere, and suburban co-working will be the new normal. "Co-working is not just about finding a cool place to work," he says. "It's about having a fabric of locations for people to figure out how they want to do their life."
Pooja Makhijani is a writer and editor based in New Jersey. She has written for The New York Times, The Village Voice, and The Washington Post.

redpajama_set_name: RedPajamaCommonCrawl


text:
Андії́ () — муніципалітет у Франції, у регіоні Іль-де-Франс, департамент Валь-д'Уаз. Населення —  осіб (2011).

Муніципалітет розташований на відстані близько 17 км на північ від Парижа, 18 км на схід від Сержі.

Географія

Демографія

Розподіл населення за віком та статтю (2006):

Економіка

У 2010 році у муніципалітеті числилось 836 оподаткованих домогосподарств, у яких проживали 2325,0 особи, медіана доходів виносила  євро на одного особоспоживача.

Визначні місця

Галерея зображень

Посилання
 Офіційний сайт
 [ Розташування муніципалітету Андії на мапі Франції та сусідні муніципалітети]

Див. також
 Список муніципалітетів департаменту Валь-д'Уаз

Примітки

Муніципалітети департаменту Валь-д'Уаз

redpajama_set_name: RedPajamaWikipedia


text:
A Glimpse into GRASP Research: Legged Locomotion
Featuring Abriana Stewart-Height
Video Version:
High School Middle School
Curriculum Connections
Bio-Inspiration – "Using phenomena in biology to stimulate research in non-biological science and technology" – George M. Whitesides
Bio-inspiration presentation by the San Diego Zoo (MS & HS)
Bio-inspiration by Prof. David L. Hu from Princeton University (MS & HS)
Gaits – "Gait is the pattern of movement of the limbs of animals, including humans, during locomotion" – Wikipedia
Dog gaits (MS & HS)
Bug gaits (MS & HS)
Gait and trajectory tutorial (HS)
Motors – "Motors are electromagnetic devices that use the interaction of magnetic fields and conductors to convert electrical energy to mechanical energy for rotation." – SeeedStudio
Degrees of Freedom – "Degrees of freedom are specific, defined modes in which a mechanical device or system can move. The number of degrees of freedom is equal to the total number of independent displacements or aspects of motion." – TechTarget
What are Degrees of Freedom? by API (HS)
Torque – "Torque is a measure of the force that can cause an object to rotate about an axis. Just as force is what causes an object to accelerate in linear kinematics, torque is what causes an object to acquire angular acceleration." – Khan Academy
Energy and a pogo stick 9-12 Pogo stick Students learn about the conservation of energy using a pogo stick
Gait Analysis 11-12 Computer access Students investigate human gaits and develop a mathematical model
How mimicking nature inspires new inventions 9-12 $0 Students use biology to develop new solutions to problems in their schools or community – from PBS
Get in Gear 6-8 Requires LEGO EV3 Students investigate gear ratios and power distribution through LEGO gears and motors
Mountain Rescue 3-5 $3/group Students simulate a search and rescue operation
Math (Common Core)
Science (NGSS)
Standard Description Standard Description
HSG.MG.A.3 Apply geometric methods to solve design problems (e.g., designing an object or structure to satisfy physical constraints or minimize cost; working with typographic grid systems based on ratios). HS-ETS1-1, HS-ETS1-2, HS-ETS1-3 Engineering Design
CCSS.MATH.CONTENT.HSF.BF.B.4 Find inverse functions. MS-ETS1-1, MS-ETS1-2, MS-ETS1-3 Engineering Design
MS-LS3-1 Complex and microscopic structures and systems can be visualized, modeled, and used to describe how their function depends on the shapes, composition, and relationships among its parts, therefore complex natural structures/systems can be analyzed to determine how they function.
MS-PS2-2 Plan an investigation to provide evidence that the change in an object's motion depends on the sum of the forces on the object and the mass of the object.
HS-LS1-2 Develop and use a model based on evidence to illustrate the relationships between systems or between components of a system.
the hierarchical organization of interacting systems that provide specific functions within multicellular organisms.
HS-PS2-1 Analyze data to support the claim that Newton's second law of motion describes the mathematical relationship among the net force on a macroscopic object, its mass, and its acceleration.
Dr. Ruzena Bajcsy receives the 2021 Rosenfeld Lifetime Achievement Award at ICCV
"Dr. Andrea Thomaz and Dr. Vivian Chu of Diligent Robotics: 'Embrace the chaos and focus on what needs your attention most'" on Thrive Global
2021 IROS Conference Papers


Welcome to our Cotton + Steel Basics Club!
Each month you'll get 5 coordinating half yards of Cotton + Steel 2019 Basics sent right to you!
This is an 8 month program beginning in January 2019 and ending in August of 2019. You will be billed on the 10th of each month and shipments will go out within 3-5 business days after payment. There is a $5 setup fee included in first month.
The price per month for the half yard bundle is $36 for US Domestic and $48 for International. Shipping is included.
We're sorry, but no cancellations at any time.
++ So sorry! This program has sold out! Stay tuned for our next one!


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[REVIEW] 'Tango Shalom' or Shall Moishe Dance?
December 1, 2021 December 8, 2021 | Rachel's Reviews
Since the early days of movie-making one of the most crowd-pleasing film genres is the dance movie. Whether it be old school Gene Kelley or Fred Astaire or more modern takes like the Step-Up movies, Footloose, Dirty Dancing, Center Stage and more. These movies usually have a similar structure and end with the triumphant last dance performance or competition. Maybe it is because I'm an absolutely atrocious dancer but these films almost always work for me. There's just something satisfying about seeing someone learn a new skill and usually they involve some level of romance, which of course I love.
This year we have a charming new entry in the dance genre entitled Tango Shalom. It is a family affair directed by Gabriel Bologna (of My Big Fat Greek Wedding fame) and written (and co-starring) his father Joseph Bologna in his final role and his Mother Renee Taylor of The Nanny fame.
It tells the story of a Hasidic Jewish man named Moishe who is struggling to pay his rent pay for his daughter's wedding. One day he stumbles upon a local dance studio and meets instructor Viviana (played by Dancing with the Stars pro Karina Smirnoff). Through various convoluted turn-of-events they end up dancing in a big prize competition and they both grow and change from the experience.
Tango Shalom reminded me a lot of the great 1996 Japanese film Shall We Dance (not the less good American remake). In that film a tired Japanese businessman sees a woman dancing and decides to take lessons from her. Like Moshe that lead is married and committed to his marriage, so this is not that kind of rom-com. No cheating is involved. In fact, in this case there is a lot of effort put into them keeping the tradition of social distancing for religious reasons. Both stories are about the connection, self-confidence and joy that comes from breaking the day-to-day grind of normal life- the happiness that comes from learning something new and having fun with a project.
I do think Tango Shalom could use some editing and not all the comedic bits work but overall it is a sweet heart-warming story with a message of faith, acceptance and tolerance. I enjoyed it and think you will too.
Tango Shalom is available to rent from all the major streamers. What's your favorite dance themed movie?
Smile Worthy
If you enjoy my writing please consider supporting me at patreon. It would mean the world to me and we have some fun perks!
Posted in 2021 movies	2021 filmsdance moviesfootlooseShall We DanceStep Up
< Current Movie Reviews
[REVIEW] 'Single All the Way': Deck the Halls with Family Happiness >
One thought on "[REVIEW] 'Tango Shalom' or Shall Moishe Dance?"
Kristina Land says:
I can't dance either (at all!) so that might be way I can't think of any dance themed movies I like. But for musicals, the dancing I've seen in West Side Story on stage was probably the best I've seen (the dancing in the 1960s movie is good, but seeing the dancing on a stage is amazing!!). I can't wait for the new movie to come out!!


1Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
2Department of Nuclear Science and Engineering and Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
3Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.Department of Nuclear Science and Engineering and Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA.
Phase-change materials that can readily switch between crystalline and amorphous states are increasingly finding use in nonvolatile memory devices (see the Perspective by Hewak and Gholipour). Using high-resolution transmission electron microscopy, Nam et al. (p. 1561) show that for Ge2Sb2Te5, the application of an electric field drives crystal dislocations in one direction, leading to their accumulation and eventual jamming, which causes the phase transition. Loke et al. (p. 1566) found that by applying a constant low voltage to Ge2Sb2Te5, they could accelerate its phase-switching speeds, without harming the long-term stability of the switched state.
Phase-change materials undergo rapid and reversible crystalline-to-amorphous structural transformation and are being used for nonvolatile memory devices. However, the transformation mechanism remains poorly understood. We have studied the effect of electrical pulses on the crystalline-to-amorphous phase change in a single-crystalline Ge2Sb2Te5 (GST) nanowire memory device by in situ transmission electron microscopy. We show that electrical pulses produce dislocations in crystalline GST, which become mobile and glide in the direction of hole-carrier motion. The continuous increase in the density of dislocations moving unidirectionally in the material leads to dislocation jamming, which eventually induces the crystalline-to-amorphous phase change with a sharp interface spanning the entire nanowire cross section. The dislocation-templated amorphization explains the large on/off resistance ratio of the device.
Chalcogenide-based phase-change memory (PCM) materials have been widely used for optical data storage and are now finding applications in electronic memory devices (1, 2). In a nonvolatile PCM device, the difference in optical reflectivity or electrical resistance between amorphous and crystalline phases is used to store information. Memory switching is performed by applying optical (or electrical) pulses: short pulses with large amplitude to amorphize the material and long pulses with low amplitude for the crystallization process. It has been generally assumed that the large amplitude of the pulse melts the material, and its short duration locks the atoms in their disordered positions owing to rapid quenching. The understanding of the effects of electric field on the crystalline-to-amorphous phase transition in PCM is critical for designing low-power nonvolatile memory devices. Therefore, it is desirable to visualize and characterize the critical events that lead to the phase-change process while the device is under operation, which can uncover phenomena that cannot be gleaned from ex situ measurements (3). However, it is challenging to resolve the amorphization phenomena with high spatial and/or temporal resolution in confined structures such as in conventional thin-film devices with a sandwich geometry (4). Very recently, based on time-resolved photo-excitation measurements of PCM materials (5, 6), it has been argued that the material did not amorphize via the liquid-state pathway, but by a solid-state, lattice-distortion–triggered process. Consequently, visualization of the structural evolution of the PCM device under electrical biasing by correlating it to the electrical-resistance variation would be helpful. A single-crystalline device can serve as an ideal platform to study the relationship between microstructural evolution and electrical resistance variation, so as to avoid the effects of preexisting grain boundaries on carrier transport and structural dynamics. In conventional PCM devices, polycrystalline thin films with relatively small grain sizes (10 to 20 nm) preclude the visualization of switching behavior originating from single grains. By using the single-crystalline, lateral, and open geometry of the Ge2Sb2Te5 (GST) nanowire structure, we visualized the amorphization behavior and found it to be critically associated with the nucleation and dynamics of dislocations.
axis were synthesized through the vapor-liquid-solid method (fig. S1) (8). For device operation, voltage pulses with duration of a few hundred nanoseconds were applied, and between each pulse, the resistance was measured at a DC bias of 0.2 V (Fig. 1B). We note that all the reported electrical resistances in this paper are not the dynamic resistances during electrical pulsing, but the stationary resistance values of the devices measured long after the pulsing process so that the heat generated during the pulsing was dissipated and the devices reached room temperature. The resistance (after each 300-ns pulse with increasing voltage amplitude) of a 280-nm-thick GST nanowire device as a function of the pulse amplitude (Fig. 1C, blue squares) decreases slightly above 3.3 V, just before amorphization electrical switching was observed. The resistance dip, however, was very small as compared with the more than two orders of magnitude increase in the electrical resistance associated with amorphization switching. There are some critical observations related to the resistance dip: (i) The decrease in the electrical resistance reflects a permanent structural change in the device while still in the crystalline state; and (ii) the critical voltage at which the resistance starts to decrease is a function of the nanowire thickness and pulse width (Fig. 1C and fig. S5). The voltage at which the resistance dip initiates decreased with increasing pulse width, and thicker wires required higher voltages and longer pulses (Fig. 1C, inset).
In situ TEM observation of the electrical switching behavior corresponding to a crystalline-to-amorphous phase change in a GST nanowire nonvolatile memory device: (A) Schematic illustration of the in situ TEM experiment using free-standing nanowire structures. (Inset) Scanning electron micrograph of a nanowire device crossing a trench region (see Methods). (B) The sequence of electrical voltage pulses applied to the nanowire device for in situ TEM and electrical characterization. The electrical resistance was measured by DC bias (shown in green) after ~0.25 s after the application of the voltage pulse. For any pulse sequence, the amplitude of the applied voltage pulse was increased with a 0.5-s interval between any two pulses while their widths were kept constant. (C) Plots of electrical resistance of the nanowire device versus applied voltage pulse amplitude obtained for different pulse width sequences, starting from a single-crystalline state. Resistance dip was observed before amorphization switching. (Inset) A plot of nanowire size versus the voltage at which the resistance dip is initiated as a function applied pulse widths.
prismatic plane, as illustrated in Fig. 1A.
Electric wind force–driven mobile dislocations and amorphization switching via in situ TEM measurements: (A to J) "Forward-bias"; (K to T) "reverse-bias," i.e., opposite polarity from the same region of the device. (A) Plot of stationary electrical resistance of the nanowire device versus voltage pulse amplitude for the forward-bias direction. The electrical resistance states are correlated with the TEM images of the device, as indicated by arrows. (B to I) Snapshots of DF TEM images (from movie S1) during electrical switching: At the early stage, individual dislocations were identified in (B) to (E), which started to propagate along the hole-carrier motion direction (F to I). The white arrows indicate the unidirectional motion of the TEM image contrast. At the bottom of the electrical resistance dip, a dislocation cloud was observed in (G) and (H). Following the resistance dip regime, amorphization occurred at the dislocation jamming region [red arrow in (I)]. (J) Larger-area DF TEM image of the free-standing GST nanowire device after amorphization, showing a dislocation trail behind the amorphized region. The blue rectangular area was recorded in the TEM movie (movie S1). (K) Plot of electrical resistance versus voltage pulse amplitude for the reverse-bias case. (L to S) From movie S2; the dislocation cloud behind the jamming region was first relieved (L to O), and subsequently another dislocation cloud was developed on the opposite front of the jamming transition region (P to S). (T) Larger-area DF TEM image of the nanowire after the reverse-polarity–biased amorphization switching, again showing a dislocation trail behind the amorphized region, but in the opposite direction as compared with (J). Scale bar: (B to I) and (L to S), 100 nm; (J and T), 500 nm. The dashed lines in (J) and (T) denote the regions where the images were combined.
Notably, upon further increasing the voltage pulse amplitude (800 ns duration), the resistance dip was directly associated with the line defects becoming mobile and propagating along the direction of hole-carrier motion (Fig. 2, C to F). This observation suggests the influence of the carrier wind force to break the symmetry of the nanowire for dislocation motion, thereby inducing a polarity-dependent behavior (9–11). The resistance continued to drop with the increase in the pulse amplitude, accompanied with the motion of dislocations from the positive to the negative electrode. In particular, dynamic contrast changes were observed moving unidirectionally in the device. Upon approaching the bottom of the resistance dip, it was observed that the dislocations stopped moving (jamming), followed by the formation of highly accumulated and entangled dislocations at the jammed location (Fig. 2, G and H, and movie S1). Finally, amorphization switching was observed, accompanied by an increase in the electrical resistance by approximately two orders of magnitude. A clear bright line was identified as the amorphous phase (red arrow, Fig. 2I), which was further characterized by electron diffraction studies (fig. S7). TEM image of the free-standing region of the nanowire (over the trench) in Fig. 2J shows a trail of dislocation cloud right behind the amorphized region. In addition, a few other dislocation cloud trails were identified along the nanowire but without any amorphous marks, which indicates that they got jammed by random perturbation in the nanowire structure, with one among them eventually undergoing amorphization. These observations show that the entangled dislocations caused by dislocation generation and jamming are precursors for the amorphization switching of the device.
To confirm that the electrical polarity determines the direction of propagation of dislocations by the carrier wind force, we performed a "reverse-bias" experiment with the opposite polarity applied on the same device (Fig. 2, K to T, and movie S2). The device was first switched back to the crystalline state, followed by the continuous application of electrical pulses with the opposite polarity in the same sequence as described above. Upon applying 500-ns-width pulses, the resistance dip was observed, during which the jammed dislocation cloud from the previous measurement was relieved by moving in the opposite direction. We then stopped pulsing at 5 V, and then applied 800-ns pulses starting from 0 V. The device resistance started from the resistance at which we stopped the 500-ns pulses (Fig. 2K), which then began to dip again from ~2 V (longer pulses lead to onset of resistance dip at lower voltages). Dynamic contrast changes were observed to move in the opposite direction, which again corresponds to the direction of the hole carriers (movie S2). Eventually, amorphization switching occurred at ~5.2 V (Fig. 2, P to S), with the dislocation cloud appearing behind the amorphous mark, consistent with the forward-bias experiments (Fig. 2T). The reverse-bias pulsing experiment clearly indicates that the mobile dislocations are transported in the direction of the applied bias, which is the direction of the motion of hole carriers in the device, suggesting a critical role of dislocation nucleation, motion, and jamming in creating the amorphous phase in the PCM device.
To better visualize the amorphization switching process, we sculpted a notch structure in the nanowire suspended over the trench to localize the phase-change region at the notch (Fig. 3) (3). In bright-field (BF) TEM image, the as-fabricated nanowire appeared uniformly dark owing to its single crystallinity (Fig. 3A). During electrical pulsing (movie S3), a change in the image contrast was observed while the device was still in the crystalline state, with the notch region developing a dark line contrast (Fig. 3B), followed by a contrast variation moving from the positive- to the negative-electrode side (Fig. 3C). The image contrast variation along the nanowire was again correlated with the resistance dip, consistent with our previous observations for the non-notched devices. Finally, upon amorphization switching, the dark line in the middle of the notch was abruptly changed into a bright amorphous band (Fig. 3D). Microstructure analysis (BF TEM images) both before and after the switching (fig. S8) shows that a highly strained structure developed in the notch region before amorphization. In particular, the amorphous mark appeared in this region of strain, which suggests the role of strain in the amorphization process. The origin of the strained structure and the differential contrast was further studied by DF TEM analysis (Fig. 3E). DF TEM revealed the presence of a high density of dislocations, predominantly at the positive-electrode side of the notch (Fig. 3E). Even though the notch structure was intended to localize joule heating by enhancing the current density, our in situ observation additionally suggests that the notch was also more likely to behave as a geometrical necking region where mobile dislocations were jammed and accumulated by the electrical wind force that did not pass through the constriction easily (see also fig. S9 for results from another device).
Transient behavior (region of resistance dip) followed by amorphization switching for a nanowire device with a notch (constriction). (A to D) Snapshots from BF TEM movie (movie S3): As-fabricated nanowire device shows a uniform, dark contrast along the nanowire in (A). As the electrical pulses were applied, the variation in TEM image contrast was identified at the moment of the initiation of the resistance dip. Darker line in the middle of the notch in (B) and (C) shows a region of highly concentrated strain, which was changed into bright contrast upon amorphization (D). (E) DF TEM image of the single-crystalline nanowire close to the bottom of the transient resistance dip: A dislocation cloud was located mostly at the (+) electrode region in (E). Scale bars (A and E), 100 nm.
In contrast to thin-film polycrystalline GST, which consists of small grains (10 to 20 nm), the single-crystalline nanowire structure rules out the effect of preexisting grain boundaries for both structural evolution and resistance dip. Our observations show that the dislocations are continuously nucleated along the single-crystalline GST nanowire, which become mobile above a certain applied voltage that is correlated to the resistance dip. The voltage pulses play a critical role by inducing heat shocks along the single-crystalline nanowire, which create dislocations by vacancy condensation (12). The rising edge of the pulse produces lattice vacancies in the material caused by heating, with the nanowire surface/interface serving as the lattice vacancy source, whereas during rapid cooling, atomic vacancies are condensed into dislocation loops by nonconservative dislocation climb (12, 13) (fig. S10). This mass-action dislocation generation path is different from purely displacive shear nucleation driven by an external mechanical stress (14–18). Because our nanowire is a free-standing structure where the thermal-expansion stress is relieved from its surface (19) and by buckling, the dislocation formation is attributed more to vacancy supersaturation (osmotic forces) than to mechanical stress. After formation, these dislocations feel the directional electrical wind force, but display a threshold behavior in mobility: that is, as a whole, they only start to move when the electrical wind force exceeds a critical value. When the dislocations become mobile, they consume more vacancies along the way by combined climb and glide actions, which decrease the carrier scattering probability, thereby decreasing the electrical resistance of the device (Fig. 1C) (13). (Dislocation dynamics are illustrated in figures S11 to S14.) Similar electrical resistance drops have been observed during rapid annealing of metals, attributed to Frank and prismatic dislocation loop nucleation and growth driven by vacancy condensation (13). Therefore, we believe that an electrical current pulse has two physical effects, one directional and the other nondirectional. The nondirectional thermal heating and quenching produce the dislocations, whereas the directional wind force moves the dislocations in the drift direction of the majority charge carrier (holes in the case of GST), leading to polarity dependence. Yang et al. (10) have reported that hole-carrier wind force in GST induces a mass transport by electromigration at high current densities, which partly corroborates our observation of polarity-dependent dislocation motion.
slips exhibit unstable generalized-stacking-fault (GSF, γ) energies of 10.1 and 172.8 mJ/m2, respectively (Fig. 4A and fig. S15).
is extremely small [similar to basal slip in graphite (20)]; in GST-layered structures with a stacking sequence -Sb-Te-Ge-Te-Te-Ge-Te-Sb-Te- (also occurs in cubic GST) (21), weak Te-Te bonding on the basal plane is the most likely to slip because of its long bond length and weak bonding energy (22).
is quite small also, comparable to that for partial dislocation slip in Cu (169 mJ/m2) (23), and much smaller than those for slips in Si (>1500 mJ/m2) (24); thus, motion of prismatic dislocation loops driven by the electrical wind force is feasible in GST (for crystallographic details on glide of prismatic loops, refer to figs. S11 to S14).
planes in hexagonal Ge2Sb2Te5. (B) Our model of dislocation nucleation, transport, and jamming by electrical pulses: At the initiation of the dip of electrical resistance, the electrical pulses induce heat shocks to nucleate dislocations from atomic vacancies. As the pulse voltage amplitude increases, the dislocations become mobile and move along the direction of holes owing to the carrier wind force. Eventually, because of the increase in dislocation density, there is a jamming transition (e.g., in the notch region or elsewhere for regular wires), where the dislocations pile up, followed by amorphous switching in the same region. On the other side of the notch, the dislocations move away from the observed region in TEM owing to wind force.
We summarize the dislocation generation and dynamics leading to amorphization switching in Fig. 4B. Both heat (nondirectional) and carrier wind force (directional) effects are consequences of the applied voltage pulses. Just before the initiation of the resistance dip, the heat-shock process by the electrical pulses leads to generation of vacancies followed by their rapid condensation to generate dislocations, analogous to generation of Frank-partial and prismatic dislocations in face-centered cubic metals by vacancy condensation (25). From our observation, it is likely that most of the dislocations are generated at the positive-bias metal electrode in contact with the nanowire (owing to material incompatibility and larger potential drop), but some of them can also be generated along the nanowire. As the amplitude of voltage pulses increases, the carrier wind force makes the dislocations mobile, gliding as prismatic dislocation loops. These dislocation loops grow in size as they move, encounter, and annihilate more vacancies, acting as "garbage collectors," which decrease the total disorder in the crystal, but also transport some disorder (in the form of dislocation cores) downstream in a one-dimensional (1D) traffic flow along the nanowire.
One-dimensional traffic flows are inherently fragile and prone to instabilities, because of interactions between the mobile agents that lead to density-dependent mobility (26). For instance, analytical models of automobile traffic on a highway predict sharp, catastrophic jamming when the automobile density exceeds a certain fraction of the maximum packing density (27). Owing to the mutual tangling that lowers their 1D mobility, the mobile dislocations moving in the direction of the hole drift can jam at some location. The dislocations then accumulate at the jammed region of the nanowire, which creates a high degree of disorder locally in the crystalline material, leading eventually to amorphization switching (28–31). Therefore, paradoxically, the mobile extended defects, which decrease the crystalline disorder elsewhere, can also greatly concentrate the disorder in a local region, when the jamming transition occurs. For nanowires without a notch, the dislocation jamming can occur anywhere when a critical dislocation density is reached in the system.
Our observations show that amorphization in PCM devices is templated by dislocation transport and jamming in the crystal. If the devices were amorphized by conventional melt-quench process, then one would have expected initiation of melting from the nanowire surface that should have spread, eventually leading to an amorphous shell around a crystalline core. Such a mechanism would have led to poor on/off resistance ratios because of resistors in parallel. In contrast, we have always observed the amorphous phase form in series with the crystalline phase (3), with the amorphous volume occupying just a tiny fraction of the total device volume, yet achieving good device performance with large on/off resistance ratios. Furthermore, in all the measured devices, the amorphous mark always appeared in front of the jammed dislocation cloud spanning the entire cross section of the nanowire and with very sharp vertical interfaces, with no amorphous phase seen anywhere else. It is thus evident that the dislocation jam with vertical boundaries provides a microstructural template for amorphization to occur in a vertical section, which is different from conventional understanding of melting that is templated by free surfaces. Solid-state amorphization is known to occur in silicon (29) and metallic (31) crystals by mechanical ball milling that injects a high density of dislocations into the material, where melting is not possible at room temperature. We cannot completely rule out the possibility of transient melting in the dislocated region, because dislocations do increase the local resistance and heat generation. The physics of such atomic disordering around dislocation cores—i.e., premelting (32)—even if it occurs, would be quite different from normal melting, because the degree of atomic disordering around dislocation cores can only rise gradually with temperature, unlike a sharp first-order thermodynamic transition in a conventional bulk melting process. In any case, our main result, which is dislocation-templated amorphization of narrow cross section with a sharp interface, is microstructural–independent of the detailed chemical physics of atomic disordering–and consistent with the observed device performance (large on/off ratio). Our results, based on direct observation by in situ TEM analysis, are consistent with several recent reports (5, 6, 33) that also have suggested non- (conventional) melting–based amorphization process in GST material.
The observation of the voltage pulse–induced dislocation nucleation, wind force–assisted dislocation glide and jamming, and subsequent dislocation-templated amorphization shed light on previously unexplored properties of these fascinating materials, relating microstructural evolution to device properties. A similar mechanism could operate in polycrystalline thin-film devices as the grain boundaries can be considered as networks of dislocations and also act as dislocation sources and sinks. Furthermore, direct visualization of various processes occurring in PCM devices under electrical bias would be promising to understand their unusual fast switching behavior and will also be applicable to other functional materials and devices.
., Phys. Rev. B 82, 041203(R) (2010).
M. H. Lee et al., IEEE International Electron Devices Meeting (IEDM), 28.6.1. (2010).
H. Zheng et al., Nat. Commun. 1, 144 (2010).
D. Hull, D. J. Bacon, Introduction to Dislocations (Butterworth-Heinemann, Oxford, ed. 4, 2001).
Acknowledgments: This work was supported by the Office of Naval Research (grant N000140910116), Materials Structures and Devices Center at the Massachusetts Institute of Technology, NSF (DMR-0706381 and DMR-1002164), and Penn-Materials Research Science and Engineering Center (DMR05-20020 and DMR11-20901). Y.C.L., L.Q., and J.L. acknowledge the support of NSF DMR-1008104 and DMR-1120901, and Air Force Office of Scientific Research FA9550-08-1-0325. Y.L. and A.T.C.J. acknowledge the support of the Nano/Bio Interface Center through NSF Nanoscale Science and Engineering Center DMR08-32802. Electron microscopy experiments were performed at the Penn Regional Nanotechnology Facility at the University of Pennsylvania. S.-W.N. thanks D. Strachan for useful discussions on in situ TEM experiments. The data described in the paper are archived by the Agarwal group at the University of Pennsylvania.


Home > Regulations & Legislation > Should the NHS Cease Food Prescriptions for Coeliac Sufferers?
Should the NHS Cease Food Prescriptions for Coeliac Sufferers?
In a recent article published to the British Medical Journal, GP Dr James Cave made some strong statements that are sure to inspire trepidation among the country's coeliac sufferers. In his article, he says that the NHS should call an end to the prescriptions for gluten-free food currently given to patients with coeliac disease, describing the current situation as a "ludicrous" arrangement which forces GPs to "behave as grocers".
"It's ludicrous for the NHS to be treating a food product as a drug and to require GPs and pharmacists to behave as grocers. It's a time-consuming rigmarole and, for the NHS, a very expensive one.
"The eight basic gluten-free staples advised for people with coeliac disease are all cheaper from a supermarket than the NHS price. This is a scandal.
"If we stopped prescribing gluten-free products tomorrow GPs would shout for joy and the NHS would stop being ripped off."
There's one particular point in the above that I would like to call attention to – the comparison in price between supermarket varieties and those supplied by the NHS. To give an example, the NHS currently pays up to £6.73 for a 500g bag of gluten-free pasta, while an equivalent product would cost just £1.20 at some supermarkets. Say what you will about the rest of his comments, but I whole-heartedly agree with him in describing that particular detail as a 'scandal'.
Last year, gluten-free prescriptions cost the NHS a total of £25.7 million, although it is worth noting that this accounts for just 0.3% of the NHS' annual prescribing budget. Now I'm not saying that this alone validates the arguments made by Dr Cave, but if the price comparisons between supermarkets and the NHS are accurate, then there is no reason for this bill to be so high.
"I think it is important for coeliac sufferers to be able to get food prescriptions, especially for the elderly and vulnerable.
"From my research, there seems to be a belief that the prescriptions should be scrapped because they are not a medicine directly designed to treat a disease. But coeliac sufferers still need to eat carbohydrates and if they are not given access to the correct types of staples they may be confused about what they can eat prompting them to choose the wrong foods and making themselves ill.
"In addition, coeliac disease is not a preventable illness so it feels wrong to penalise people for something they have no control of, while the NHS continues to treat people for illnesses and disorders caused by lifestyle choices."
He also questioned Dr Cave's belief that scrapping gluten-free food subscriptions would save the NHS money. Focusing on the long term, he said, "Coeliac sufferers who don't eat the correct foods can put themselves at risk of long term health problems including bowel cancer which will put more pressure on the NHS at a later date."
So, which side of the debate do you fall on?
Should we stop treating such foods as medicine, as Dr Cave believes? Or do you side with Mr Johnson & little Amelia? Let us know in the comments below.


Goldfish are a temperate fish found in cool streams, lakes, and ponds throughout Asia and part of eastern Europe, though all the Veil Tail Goldfish specimens found in the hobby today are captive bred. Goldfish can be easy to care for, however, they do require some care.
Given proper care and a good, healthy environment, goldfish can sometimes live nearly 50 years! To keep a goldfish healthy, remember to provide them with plenty of clean, cool water. Your goldfish's temperature should never rise above 74 Degrees Fahrenheit (about 235 Degrees Celsius), and ideally should remain between 65 Degrees and 68 Degrees F (18 Degrees and 20 Degrees C). Keep your goldfish in a fish tank no smaller than a 10 gallon (about 38 liter), and make sure that a minimum of 6 gallons (23 liters) of the space in that fish tank is dedicated to each goldfish (each goldfish should have 6-8 gallons or more (roughly 23 to 30 liters or more) space in the goldfish aquarium). A 10 gallon fish tank is really only suitable for one goldfish.
Your goldfish will need a filter to keep the water from becoming toxic, and you will need to keep the filter in Ryukin Goldfish good condition. When selecting a filter, if you have fancy goldfish, make sure that the filter will not produce excessive current in your fish tank, and this will make it difficult for the fancy goldfish to swim. Goldfish should never be kept in a fish bowl. Remember that your goldfish is an omnivorous (eats anything) scavenger, so provide him with a varied and high carbohydrate diet. Many goldfish foods are available on the market today, and most frozen fish foods are also appropriate, provided you do not feed meaty foods too often.
Goldfish have large appetites, but they also graze for food constantly. Don't let their 'mock hunger' and grousing around for food fool you into over feeding them. Your fish should be able to consume all the food you offer within two minutes of feeding. If there is food in the aquarium after this time has elapsed, this will contribute to poor water quality and make your goldfish more susceptible to disease. You will only need to feed your goldfish once a day.
If you feed more than once a day you will increase the waste your fish is producing and will also increase the risk of over feeding, so it becomes more important that you are performing your weekly 10 to 15% water changes and all necessary filter maintenance. Providing a proper diet will increase your goldfish's life expectancy and bolster their immune system. Goldfish, like almost any fish, are aware that they are prey animals. In order to feel comfortable, they need to have lots of hiding places. Goldfish do not seem to be too particular about their cover, however, you do want to make sure that you do not use any sharp or rough decorations that your goldfish may get hurt on, especially if you are keeping any fancy goldfish that have impaired vision.
Like most other fish, they are more comfortable and will come out more and be more active if you can provide them with 50 to 75% cover – this means you should make half to three fourths of your tank space hiding places. Providing sufficient cover will reduce stress and therefore improve your goldfish's immune system, reducing chance of disease. Goldfish can, like most fish, be kept with fish with similar care requirements and temperament. However, this very quickly limits you Fantail Goldfish to other goldfish – fortunately, there are many different and interesting fancy goldfish to choose from. When looking for a companion for your goldfish, remember to select goldfish with similar handicaps.
If their disabilities are too different, it is very likely that some will out compete the others for food, and you can have a goldfish starve to death while another gets fat right before your eyes in your fish tank. Remember, goldfish are beautiful living creatures. It is the responsibility of the pet owner to care for their pet and provide a healthy environment. So give your goldfish space, clean, cool water, plenty of hiding places, and high-quality, high-carbohydrate foods and he should be a good companion for a long time.


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Michael Collins Discusses the Sound and Influences of Drugdealer
Five years Strong: Splice Records Still Turns the World One Album at a Time
Weekend Music: Murder on Memorial Day
Houston Press | May 23, 2008 | 11:39am
Fifteen years ago next month, shock-punk hero GG Allin's brief but eventful life came to an end when his wildly overtaxed body had all it could handle and finally gave out after one shot of heroin too many. Naturally, Allin's legend has only grown since then, aided by 1994 documentary
Hated: GG Allin and the Murder Junkies
(the first film by
director Todd Phillips) and the indelible memories of nights like February 18, 1992 at Austin's Cavity Club.
That gig, like many others, ended with the bloodied and feces-covered Allin being hauled off to jail (read the arrest report here). "Allen asked why the police Maced him," the arresting officer noted, "and I advised him it was not the police." Now led by Allin's bass-playing brother bass-playing brother Merle, the Murder Junkies have gotten sentimental in their middle age - their tour marking the 15th anniversary of Allin's death stops at Walter's tonight with Los de Verdad, Rats in the Attic and Riot Up Front. They might be getting a little old to shit onstage, but then again, you never know.
Elsewhere, Dallas' Forever the Sickest Kids weren't even a week old when their singer accidentally bought a front-page ad on www.purevolume.com, inadvertently sparking an eight-label bidding war when "Hey Brittany" - hastily written so his $350 wouldn't go to waste - drew 2.5 million plays. Ah, the Internet. Tonight the Kids headline a bill of bands barely old enough to shave at Warehouse Live, with Metro Station (Hollywood, featuring Miley Cyrus' stepbrother), the Cab (Vegas), the Maine (Phoenix) and Danger Radio (Seattle). Bob Schneider, who some of you UT exes and other former Austinites may have heard of, touches down at Meridian this time, with Houston's jam-tastic Plump in tow. And it's Prom Night at the Continental Club, with Molly & the Ringwalds and Disco Expressions spiking the punch. Prom attire required.
Saturday, Austin's UME, currently trying to land their abrasive pop at Lollapalooza via the "Last Band Standing" contest (vote here), scour the Mink with Lymbyc System and the not-at-all-depressing Sour Notes. Don't forget about Meridian's benefit for cancer-stricken former The Tie That Binds drummer Alex Arizpe , while Dallas' Miser tops a modern-rock night in the main room with Dawn Over Zero, Subversa and Pale.
Washington D.C. Warped Tour pickups You, Me, and Everyone We Know do it for the kids at Javajazz with Cinematic Sunrise, Daphne Loves Derby, Dropping Daylight, Playradioplay!, Alive in Wild Paint and My American Heart. Montrose irie posse Ryan Scroggins and the Trenchtown Texans and Chango Man, heirs to the beloved tamale-flingers Chango Jackson, scoff at sobriety at the Continental Club, and New Jersey R&B crooner Jaheim, grandson of onetime Drifters member Victor Hoagland, will pick and choose from his albums Ghetto Love, Still Ghetto, Ghetto Classics and last year's Makings of a Man at the Arena Theater.
Sunday, the Lord's Day, Adversary Productions makes a joyful noise at Meridian with the acoustic campfire folk (kidding... please don't disembowel me) of Infernaeon, Fierce Allegiance, Uncleansed, Hod, Ebonmortis and Funeralcult. Brooding Richmond rockers Mooney and Houston's equally melancholy Las Imagenes Ocultes head up a rock en espanol evening at Warehouse Live. And if you missed Iron Maiden yesterday, Vancouver powerslaves 3 Inches of Blood, headlining the Jaegermeister Music Tour Sunday at Verizon with Hatebreed, Type O Negative and the Destro, might just be the next best thing. - Chris Gray
The Houston Press is a nationally award-winning, 30-year-old publication ruled by endless curiosity, a certain amount of irreverence, the desire to get to the truth and to point out the absurd as well as the glorious.
The Sax of Boney James Wafts Across the Studio, the Stage,...
30 Songs By 30 Acts From 30 Days of Music in Houston, Closing Set
Houston Concert Watch 7/10: 21 Savage and More
21 Savage Brings His Tour To White Oak Music Hall


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Historic Hyde Park a Draw for Seniors after Retirement
Hyde Park is, without a doubt, one of Cincinnati's most desirable communities. With easy access to shopping, downtown and major highways, it is a prime example of lifestyle that balances urban sophistication with historic charm.
When Hyde Park was founded in 1892, Cincinnati's population hovered around 300,000, making it the 9th largest city in the nation. Developers had already crowded the riverside communities and the hills overlooking downtown Cincinnati.
A group of wealthy and well-connected men with now-familiar names like Kilgour, Mooney, Burch and Zumstein pooled their prodigious funds and formed the Mornington Syndicate. They proceeded to purchase nearly all the property in a triangle formed by Edwards Road, Observatory Ave. and what was then known as Madison Pike.
Soon, there were massive improvements— a grid of streets, paved boulevards, street cars connecting the new neighborhood to the rest of the city. But it went without name until one member suggested renaming Mornington Syndicate after a well-to-do town outside of New York City – Hyde Park.
And so Cincinnati had what would become and remain, for more than 120 years, one of its most exclusive and sought-after communities.
And with plenty of local highlights, it's the perfect place to kick back and enjoy life after retirement.
Hyde Park Square
The centerpiece of life in Hyde Park, this classic town square spills out from its center along Erie Avenue between Edwards Road and Michigan Avenue, filled with independent restaurants, banks, a firehouse, a post office and shops. You'll find everything here, from fine jewelry and wine to children's clothes and yoga gear.
The Cincinnati Observatory Centre
Located on a sleepy side street off Observatory Avenue, this is the oldest professional observatory in the United States. Its original location (in 1843) was in what we now know as Mt. Adams. Thirty years later, it moved to its current location to escape the lights and pollution of downtown. There are a wide variety of public programs at the observatory, including many opportunities to view the heavens through one of its two large telescopes. (3489 Observatory Place, 513-321-5186, Cincinnatiobservatory.org.)
Rookwood Commons & Pavilion
Even though this sprawling shopping center is technically not in the community proper, located a stone's throw from the Hyde Park border at the corner of Madison and Edwards roads, it is a favorite destination for Deupree residents. Filled with a wide range of restaurants and, in some cases, exclusive outlets— Whole Foods Market, Joseph-Beth Booksellers, Sur La Table, REI and many others— it is one of the area's most in-demand shopping destinations.
You don't have to give up the pleasures of country club life if you move back to the city after retirement— Hyde Park has two of them! Cincinnati Country Club is at the west end of Hyde Park near the corner of Observatory Avenue and Madison Road, though the entrance is on Grandin Road, while Hyde Park Golf & Country Club is in the northwestern reaches of Hyde Park on Erie Ave.
There are several fine galleries in the community, but three of the most intriguing and best-established are the Malton Gallery (3804 Edwards Rd., across from Rookwood Commons), the Miller Gallery (2715 Erie Ave., on Hyde Park Square) and the Raymond Gallery/The Framery (3508 Edwards Rd., just off Hyde Park Square).
Hyde Park Farmers' Market
Summertime in Hyde Park heralds the start of the community's a first-class urban farmers' market, filled with vendors selling mostly organic products and produce from small, independent farms. Traditionally, it takes place every Sunday from June through September from 9:30 a.m. to 1:30 p.m. in the U.S. Bank parking lot located at 3424 Edwards Rd., between Erie and Observatory avenues.
Hyde Park Square Art Show
Once again, all signs point to Hyde Park Square. The 2014 Hyde Park Art Show, on October 5, will be the 48th annual gathering. It is the largest one-day curated art show in Greater Cincinnati, typically displaying the works of more than 200 artists.
activities for seniors life after retirement senior living Hyde Park
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Tag: Regulatory Exclusivities
A More Transparent System for Clinical Trials Data in Europe – Mind the Gaps!
May 1, 2014 May 1, 2014 Timo Minssen	Leave a comment
By Timo Minssen
Following the approval of the European Parliament (EP) earlier last month, the Council of the European Union (the Council) adopted on 14 April 2014 a "Regulation on clinical trials on medicinal products for human use" repealing Directive 2001/20/EC. As described in a press-release, the new law:
"aims to remedy the shortcomings of the existing Clinical Trials Directive by setting up a uniform framework for the authorization of clinical trials by all the member states concerned with a given single assessment outcome. Simplified reporting procedures, and the possibility for the Commission to do checks, are among the law's key innovations."
Moreover, and very importantly, the Regulation seeks to improve transparency by requiring pharmaceutical companies and academic researchers to publish the results of all their European clinical trials in a publicly-accessible EU database. In contrast to earlier stipulations which only obliged sponsor to publish the end-results of their clinical trials, the new law requires full clinical study reports to be published after a decision on – or withdrawal of – marketing authorization applications. Sponsors who do not comply with these requirements will face fines.
These groundbreaking changes will enter into force 20 days after publication in the Official Journal of the EU. However, it will first apply six months after a new EU portal for the submission of data on clinical trials and the above mentioned EU database have become fully functional. Since this is expected to take at least two years, the Regulation will apply in 2016 at the earliest (with an opt-out choice available until 2018).


Kolean brings more than 25 years of bioscience industry experience as a results-driven financial executive.
Titan Spine, a medical device surface technology company focused on developing innovative spinal interbody fusion implants, has announced the appointment of Chad Kolean as the company's chief financial officer (CFO). In his role, Kolean will oversee Titan's finance team and work to build forward-looking financial preparedness as the company continues to experience rapid growth following the launch of its nanoLOCK surface technology.
Prior to joining Titan, Kolean served as the CFO for Cellectar Biosciences, a life sciences company, where he drove a management restructuring and raised substantial funds resulting in uplisting to the NASDAQ Capital Market. Previously, he served as the CFO at Pioneer Surgical Technologies, providing the organization with leadership strategy, development and execution, Board support, investor relations, budgeting, forecasting, operations and regulatory due diligence. Kolean is a certified public accountant and earned his B.A. in Business Administration from Hope College.
Titan Spine offers a full line of endoskeleton titanium implants that feature its proprietary nanoLOCK surface technology, which was launched in the U.S. in October 2016 following FDA clearance in late 2014. The nanoLOCK surface technology consists of a unique combination of roughened topographies at the macro, micro, and nano levels (MMN). This unique combination of surface topographies is designed to create an optimal host-bone response and actively participate in the fusion process by promoting the upregulation of osteogenic and angiogenic factors necessary for bone growth, encouraging natural production of bone morphogenetic proteins (BMPs), downregulating inflammatory factors, and creating the potential for a faster and more robust fusion.1-3 All Endoskeleton devices are covered by the company's risk share warranty.
1 Olivares-Navarrete, R., Hyzy, S.L., Slosar, P.J., Schneider, J.M., Schwartz, Z., and Boyan, B.D. (2015). Implant materials generate different peri-implant inflammatory factors: PEEK promotes fibrosis and micro-textured titanium promotes osteogenic factors. Spine, Volume 40, Issue 6, 399–404.
2 Olivares-Navarrete, R., Gittens, R.A., Schneider, J.M., Hyzy, S.L., Haithcock, D.A., Ullrich, P.F., Schwartz, Z., Boyan, B.D. (2012). Osteoblasts exhibit a more differentiated phenotype and increased bone morphogenetic production on titanium alloy substrates than poly-ether-ether-ketone. The Spine Journal, 12, 265-272.


Ships tomorrow if ordered in the next 2 hours and 5 minutes!
• High density Gel memory foam Pillow. Traditional pillow size and shape fits standard pillowcases and measures 24" L x 14" W x 4 1/2".
Dual height design both sides provides good support and perfect head-neck-shoulder alignment. Stay cool and comfortable throughout the night while getting the support you need with the Dual Design.
The soft, luxurious zip-off cover is machine washable and resistant to allergens and mites. You'll wake rested, rejuvenated and ready to take on the day.
Review "Abripedic Dual Contour Gel Memory Foam Pillow (each)"


Deadline is an interesting idea to look at. It seems to me that deadlines do not work well on metas, because users may answer any time in the future, even years after the implementation and suggest a better approach. It seems to be on case-by-case basis.


This section lists each of the current operational divisions within Shadowserver. The basic roles and responsibilities of each divison is listed as well.
Within some teams, are several volunteer security consultants that are instrumental to the overall responsibilities of their team.
Online identity theft, phishing and credit card theft are an overwhelming part of the internet underground. The eFraud Division sifts through this underground to gather and process intelligence that can assist the appropriate authorities in shutting down these operations. These reports are regularly fielded directly to law enforcement and banks in order to limit loss.
Establishing and maintaining working relationships with LE and CC organizations.
Redundant backups of all logs in accordance with strong encryption standards.
Our initial focus and most popular division is related to botnet intelligence. Botnets are used as a weapon in online crime. From DDoS attacks, spam email, identity theft through keyloggers, and the spreading of malware these nets are the mafia of the internet. At any given time there are over 100 networks under constant surveillance, with many more checked up on regularly.
Ensuring that all reported botnets are entered into the ticketing system.
Updating the status of assigned botnets.
The timely processing of newly submitted tickets or reports.
Reviewing botnet logs for patterns, activity, and other intelligence.
Sending abuse and notification emails to the appropriate providers.
Maintaining and building working relationships with LEO, service providers, and other security oriented organizations.
Forwarding malware to the Shadowserver malware team.
Redundant backups of all logs according to strong encryption standards.
This division focuses on disassembly and reverse engineering viruses, trojans, and other types of hostile code. Several thousand files have been reverse engineered by this division. They currently boast an impressive repository consisting of over 32,000 sample binaries, and over 12,000 unique viruses!
Establishing and maintaining contacts with antivirus or spyware vendors including BleedingSnort.
Offer samples of undetected malware if required.
Obtaining licenses for antivirus products.
Processing or working all malware provided by the honeypot or botnet team.
Manually analyzing hostile code if automated sandboxing fails ie. advanced redpill, timeout, etc.
The primary focus is to collect malware, phishing scams and other data which is later examined by the other divisions. With honeypots spreading to nearly every part of the world, we are likely to see events as they happen, rather than reporting on them days or weeks later.
Scrubbing Searchirc, Netsplit.de, Google API, etc. for malware.
Establishing email drops and trolling with those drops on newgroup and forum sites.
Locating bot sources and exploits.
Establish and maintain working relationship with groups such as Nepenthes and iDefense.
Maintain autosubmission process to the Malware team.
The Toyshop builds and enhances custom applications and reports to benefit overall Shadowserver operations.
Automation of processes and reports.
Researching and developing workarounds for advanced redpill or other vm detection.
Studying the feasibility of other back-end projects for future development.
Maintaining the content on the Shadowserver website.
Maintenance of the Shadowserver mailing lists.
Providing overall direction and management for the Shadowserver Foundation.
Press releases and interview coordination.
Protection of assets and staff.
Building and developing relationships with outside organizations such as vendors, service providers, and LEO.
The release and dissemination of Shadowserver intelligence.
All business and financial matters related to the non-profit operation of The Shadowserver Foundation.


The SFT is the latest and most innovative make-pack line on the market for MYO (Maker-Your-Own) filter tubes production.
Since its development, SASIB sold over 15 make-pack lines (composed of SFT-M and SFT-P machines combined), which have been already installed in Europe, Middle East and Far East, and more lines are expected to be ordered during the year.
SASIB is proud to state that these machines have successfully passed the acceptance protocol with an output rate of over 90%.
With the SFT, SASIB has achieved impressive results in the filter tubes machinery market thanks to its recently developed high technology which allows to bring the production speed up to 7,200 tubes per minute, packed in a range of different sized boxes containing from 100 to 500 filter tubes, and to its very easy and quick switch from one filter tube collation to another one.
As well as technological innovations, the SFT features strong points such as its space-saving design compared to the other lines currently existing on the market, and the need of only one operator for the packer.


American Bar Association says lawyers can visit social media sites of jurors, even during deliberations. Facebook changing right-hand-side ads this week. These stories, and more, in today's Morning Social Media Newsfeed.
Lawyers have been given the green light to scan the social media sites of jurors. The American Bar Association says it's ethical for lawyers to scour online for publicly available musings of citizens called for jury service — and even jurors in deliberations. KWTX The "formal opinion" was issued in April and will serve as an ethical guideline for the nation's lawyers. The ABA's ethics committee began reviewing the issue about two years ago and concluded that looking at Facebook posts, tweets and other information gathered passively is ethical research. Mod Vive Honestly, this practice has likely been occurring for years. Social media has already become a wealth of information for attorneys in both civil and criminal cases to find information on the opposing party.
Facebook announced that it will begin rolling out its redesigned right-hand-side ads early this week. The revamp of those ad units was originally announced in April.
Writing for Entrepreneur, digital marketing consultant Brett Relander offered up five common sense yet often overlooked social media hacks to grow your business: know what's hot, speak the language of social media, grow your base, save time and embrace change. Automating certain activities such as sharing content across platforms, sending email and SMS updates on topics of interest, and uploading social media content to remote storage saves time and can be utilized by either enterprise-level or grassroots organizational systems.
A company called Modus Operandi is developing a "social network" interface with profiles of the bad guys who want to do you harm. Terrorists, mainly.
The Guardian has a fascinating interview with Twitter co-founder Biz Stone, who is promoting his new book, "Things A Little Bird Told Me." The juicy bits are found in Stone's recollection of meetings with Mark Zuckerberg, back when the Facebook founder was thinking about buying Twitter.
Still no official word on that acquisition reported by Variety last month, but YouTube and Twitch are getting together in a different way. When Twitch broadcasters who also use YouTube turn on a new feature called Live Annotations, a notification like this will automatically appear over their YouTube videos once they start a new live broadcast.
John Stamos was squeaky clean back in his "Full House" days, but earlier this week, he got a little risque with one of Vine's most notorious pranksters. Prolific Vine user Jerome Jarre, who is known for springing up on people armed with kisses, tried to surprise Stamos. But Stamos was ready.
The number of public school teachers facing disciplinary action in Tennessee is on the rise, and social media could be partly to blame. A Chattanooga Times Free Press review of disciplinary data over the past decade data shows teachers are increasingly failing to maintain appropriate boundaries as the proliferation of social media facilitates constant communication between teacher and student.
The John S. and James L. Knight Foundation, an organization that promotes innovation in journalism, is sponsoring a new comments infrastructure project for journalism sites to the tune of $3.9 million. According to The Times digital media reporter Leslie Kaufman, the infrastructure will take around two years to build, and the platform will be offered to other news organizations for free once the project is complete.


text:
import Cache from '../src/js/core/cache';

describe('cache', () => {
  let url = '/homepage.html';
  let cache = new Cache();
  // remove from cache if exists (local storage)
  cache.removeCache(url);

  describe('.setCache', () => {
    it('should set in cache', (done) => {
      let cacheData = cache.setCache(url, {});
      expect(cacheData).to.be.a('object');
      expect(cacheData.attributes.id).to.equal(url);
      done();
    });
  });

  describe('.getCache', () => {
    it('should get from cache a null value', (done) => {
      let cacheData = cache.getCache('/fake-url.html');
      expect(cacheData).to.be.null;
      done();
    });

    it('should get from cache', (done) => {
      var cacheData = cache.getCache(url);
      expect(cacheData).to.be.a('object');
      expect(cacheData.attributes.id).to.equal(url);
      done();
    });
  });

  describe('.removeCache', () => {
    it('should remove from cache', (done) => {
      let cacheData = cache.removeCache(url);
      expect(cacheData).to.be.true;
      done();
    });
  });
});

redpajama_set_name: RedPajamaGithub


God, in return for Pinhas' actions, rewards him with the brit shalom (covenant of peace). Pinhas' actions, which God describes as being "b'kano et kinati", is translated by some as "zealous for My sake". This specific action of Pinhas, when described as zealotry, seems scary to the modern reader. Nowadays, religious zealotry often holds negative connotations, and especially in this narrative where the result is the death of two human beings solely on God's behalf. Of course, one could simply console the discomfort by stating that political correctness and religious fundamentalism were never seen as problematic in biblical times. God's praising Pinhas' kinahtells of the correctness of his actions. Why then, shouldn't this apply to all cases?
However, Alex Israel––a contemporary teacher of Tanakh––claims that in fact the Hebrew root kana shouldn't necessarily be translated as zealotry. If one takes a closer look at the biblical story of sotah (Numb. 5:11-31), where the word kinah is used a number of times, the meaning of the word can actually be interpreted as "a state of impassioned emotion, the temperament that enlivens a person engaged in a relationship of exclusivity." The husband in the case of sotah acts not from zealotry, but from suspicion and passionate outrage at the possibility of betrayal. So too, remarks Israel, in the case of Pinhas. He finds the relationship of God and Israel to be breaking, and in sheer passion does he act to save the Israelite's lives in addition to their relationship with God. This act was not committed out of anger, rather motivated by ideals, whereby Pinhas arouses the nation from their deviance and restores some sense of order. Israel finally describes kinah as "the heightened awareness, the indignation, the sensitivity and passionate resolve to make a difference." Thus, the trait and motivations ofkinah can be seen as proper, and perhaps even necessary for acting in a scenario of dire importance. Such a message calls to every human being; that when one finds something terribly wrong in the world they becoming filled with kinah, whose result will hopefully not be murder, but the mending of a situation, be it on a global or personal level. The importance lies in the fact that one is filled with passion to the point that they must stand up, and won't simply sit by "weeping at the entrance of the Tent of Meeting". This can perhaps make sensible the reward of the brit shalom. Only in such pressing circumstances, and only when such actions are motivated by a passion for change can an everlasting covenant of peace be the final result.


text:
Regional Recycling Nanaimo Supervisor Mike Woodruff holds examples of used beverage products worth a refund of 10 cents each since Nov. 1, when Encorp Pacific doubled the deposits for certain types of containers.
Deposits for some bottles has doubled! Here's how to keep refund revenue local
The refund for non-alcohol beverage containers up to a litre in size rose on Nov. 1 from 5 cents to 10 cents each, when customers redeem them at depots province-wide.
The types of containers with an updated deposit include aluminum, plastic, drink boxes, gable top cartons often used for liquid products, glass, bi-metal, pouches and polystyrene cups.
While Regional Recycling Nanaimo General Manager Paul Shorting applauds the decision of Encorp Pacific, the not-for-profit stewardship agency responsible for managing B.C.'s Return-It beverage container system, to increase the deposit, he said it's just a start.
"It's an initiative to change people's habits to recycle more beverage containers — that's great," Shorting said of the decision, which coincided with national Waste Reduction Week. "But a million beverage containers per day go missing in B.C., and we should be doing more for our environment, to keep them out of our waterways and landfills."
Shorting was referring to a report conducted by the Ocean Legacy Foundation that was released this year, which also found 2.3 million caps go missing every day in the province.
He said Nanaimo has one of the highest recovery rates in the province for beverage containers, but there is still a percentage of residents who don't recycle.
Further, he said residents who do recycle should consider keeping the revenue within the community.
Rather than placing used beverage containers in the curbside recycling, he said residents should consider bringing them to one of the Regional Recycling locations on Old Victoria Road or Hayes Road.
"The 10-cent containers people deposit in their recycling bins ends up being paid to a multinational company through a processor in the Lower Mainland," he said. "Even though the customer may be doing the right thing to recycle, that revenue is leaving the city."
Another way to keep refund money for containers in the city is by organizing or supporting a bottle drive, or local community groups.
Shorting said the Loaves and Fishes Community Food Bank Empties Recovery Program has deposit container donation bins at more than 20 locations in town. All of the proceeds the food bank earns from the recycling they collect goes to ensuring people in Nanaimo have access to healthy, nutritious food.
For a list of the locations where Empties 4 Food bins can be found, visit www.nanaimoloavesandfishes.org/get-involved/empties-4-food.
Regional Recycling Nanaimo depots are located at 839 Old Victoria Rd. and 2375 Hayes Rd. The depots are open Monday through Saturday from 8:30 a.m. to 5:30 p.m. and Sunday from 10 a.m. to 4 p.m.
For answers to questions or for more information, call Regional Recycling at 1-855-701-7171, or email Paul@RegionalRecycling.ca to book a bottle drive.
25 years of goodness: Training nutritionists to help others enjoy better health
A new era for radiation therapy


This collection of correspondence includes 20 letters with envelopes and 6 envelopes without accompanying letters. All letters are addressed to Hugh Bolton Jones, father of a Maryland landscape painter who bore the same name. The most frequent correspondents are his wife Laura, his daughter Louise, and his son also named Hugh Bolton Jones. There are also several letters from Jones's business acquaintances.
>>> Read the finding aid.


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