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High-Grade B-cell Lymphoma with MYC and BCL2 and/or BCL6 Rearrangements
Kate Berry, MBBS, BBus (Hons), Pathology Queensland
3 Cancer Sub-Classification/Subtype
4 Definition/Description of Disease
5 Synonyms/Terminology
6 Epidemiology/Prevalence
High-grade B-cell lymphoma
Cancer Sub-Classification/Subtype
Definition/Description of Disease
High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements is a clinically aggressive lymphoma with poor prognosis. It is defined as a distinct entity which includes mature B cell neoplasms harbouring both MYC and BCL2 and/or BCL6 rearrangements, as detected by a cytogenetic/molecular method such as FISH, except for cases of proven follicular lymphoma in the absence of a concurrent high-grade component, or where the disease is classified as B-lymphoblastic leukaemia/lymphoma[1].
Synonyms/Terminology
"Double-Hit Lymphoma (HGBL-DH)" in cases with MYC and BCL2 OR BCL6 rearrangement.
"Triple-Hit Lymphoma (HGBL-TH)" in cases with MYC, BCL2 AND BCL6 rearrangement.
Obsolete: B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma
Epidemiology/Prevalence
HGBL DH/TH accounts for 3-9% of diffuse large B-cell lymphoma and approximately 13.3% of the germinal centre B-cell-like subtype[1][2][3][4][5][6]
HGBL DH/TH accounts for approximately 1.7% of activated B-cell-like diffuse large B-cell lymphoma[2]
These tumours overwhelmingly show concurrent MYC and BCL6 translocations, and the existence of activated B-cell-like high grade B cell lymphoma with BCL2 translocation is controversial[2]
MYC translocations occur concurrently with BCL2 translocations in 57-87% of cases and with BCL6 translocations in 5-30% of cases. MYC, BCL2 and BCL6 translocations ("triple hit") are present in 7-15%[7][8][9]
The diagnosis is slightly more common in males
Median age at diagnosis is 6th to 7th decade[1][10]
Patients typically show Ann Arbor stage IV disease at diagnosis[11] with involvement of more than one extra-nodal site and a high International Prognostic Index (IPI) score[1][3][12]. B symptoms (fever, night sweats and weight loss) are common at diagnosis, as is poor performance status[3][8][12]. Patients almost invariably show elevated serum lactate dehydrogenase and, less frequently, leucocytosis[3][5][8][10][12].
· Lymph nodes
· Extra-nodal sites
· Bone marrow
· Central nervous system
The morphological appearances of HGBL-DH/TH are variable, and histology alone is an unreliable predictor of double- or triple-hit status[13]. Recognised morphologies include features of diffuse large B cell lymphoma (DLBCL), NOS, with a diffuse growth pattern, variably sized nuclei with irregular nuclear contours, often with plentiful basophilic cytoplasm and variable numbers of mitotic figures and tingible-body macrophages; Burkitt-like cytomorphology, with a diffuse proliferation of medium-sized to large, often very monomorphic, lymphoid cells with intermixed tingible-body macrophages and plentiful mitotic and apoptotic figures, imparting a "starry-sky" appearance; or an intermediate appearance with sheets of medium-sized cells with finely granular blastoid-like nuclear chromatin, inconspicuous nucleoli and scant cytoplasm.[1][8][10].
When classified by cell of origin based on immunohistochemistry according to the Hans algorithm[14], the vast majority (70-90%) of HGBL-DH/TH are of germinal-centre B-type[3][4][5][7][9][10][15][16]. This is especially true of HGBL with MYC and BCL2 translocation which is overwhelmingly shown to be of germinal centre origin, as per the Hans algorithm or by cell of origin gene expression profiling[2][7]. Some authors regard this entity, along with triple hit cases, to be exclusively germinal centre B-cell derived and believe the small numbers of ABC cases identified by some studies to have been misclassified as a result of cell of inaccurate cell of origin testing[2].
HGBL with MYC and BCL6 translocation is a more heterogenous entity with both germinal centre b-cell-like and activated b-cell-like cases occurring[4][7][16].
Although HGBL-DH/TH includes a significantly higher proportion of tumours with immunohistochemically detectable overexpression of MYC and BCL2 and/or BCL6 than DLBCL as a whole[2], in the absence of confirmed gene rearrangements this is insufficient for diagnosis[1]. The high prevalence of C-MYC protein expression in DLBCL in the absence of chromosomal translocation suggests alternative mechanisms may lead to similar overexpression, such as MYC gene mutations or amplifications[13][17].
Although the proliferative index of these tumours is variable, in contrast to Burkitt lymphoma the Ki67 staining rate is is predominantly lower than 90% when measured by immunohistochemistry[7].
Positive (almost universal) CD20
Positive (typically) CD10, BCL2, BCL6, MYC, MIB-1
Negative (almost universal) CD3, cyclin D1, TdT
Negative (typically) CD5, MUM1, EBER
This subtype of B-cell lymphoma is defined by a rearrangement of the MYC proto-oncogene, located on chromosome 8q24. In 39-65% of cases the translocation partner is an immunoglobulin gene, most commonly the IGH region on chromosome 14q32 with the IGK (2p12) and IGL (22q11.2) gene loci less frequently involved[1][4][5][7][10][18]. Non-IG gene partners include 9p13 and 3q27.3 (BCL6)[7]. Additionally, all cases must harbour a BCL2 (18q21.3) and/or BCL6 (3q27.3) rearrangement.
Chromosomal Rearrangement
Genes in Fusion (5' or 3' Segments)
Pathogenic Derivative
t(8;14)(q24;q32) IGH-MYC der(14) 28%[19]
t(8;22)(q24;q11) MYC-IGL der(8) 7%[19]
t(2;8)(p12;q24) MYC-IGK der(8)
t(14;18)(q32;q21.3) IGH-BCL2 der(14)
t(2;18)(p11;q21.3) BCL2-IGK
t(18;22)(q21.3;q11) BCL2-IGL
t(3;14)(q27;q32) IGH-BCL6
High-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements almost invariably display a complex karyotype with many cytogenetic abnormalities[1][5][10]. Gains of chromosomes 8q and 12q are more common in HGBL-DH/TH than in cases with isolated MYC translocation[7]. 12q12-q15 copy-number gain is significantly more common in HGBL with MYC and BCL2 translocation than in cases with BCL6 translocation[10].
Other common aberrations include[10]
Chromosome Number
Gain/Loss/Amp/LOH
3 Gain p12.1-q29
7 Gain p22.3-p11.1
12 Gain p13.33-q21.31
1 Loss p36.33-p36.32
6 Loss q22.1-q23.2
15 Loss q14-q21.3
1-3 LOH 1p32.3-3p21.31
Due to the relatively recent classification of HGBL with MYC and BCL2 and/or BCL6 translocation as a specific pathological entity, combined with small sample sizes, comprehensive data on gene mutation prevalence is not currently available. However, several studies have shown the mutational profile of HGBL DH/TH to differ significantly from that of DLBCL, NOS. Frequently mutations are associated with apoptosis and cell cycle pathways known to be associated with poor prognosis in DLBCL patients, including SOCS1 non-truncating mutations and mutations in CREBBP and FOX01[9]. HGBL DH/TH also shows a significantly higher number of IGH and MYC mutations than DLBCL with isolated MYC translocation[7]. MYC hotspot mutations occur more frequently in cases in which the MYC translocation partner is an immunoglobulin gene, and are associated with high MYC protein expression[6]. Amongst the most frequently mutated genes, somatic CREBBP mutations have been shown to inhibit TP53 tumour suppressor activity through activation of the BCL6 oncoprotein[9]. KMT2D mutations consist primarily of frameshift deletions and stop gain alterations with subsequent loss of protein function[9].
Amongst HGBL DH/TH cases, the nature of the secondary translocation also affects the mutational landscape, with TP53 mutations, associated with significantly worse overall survival, occurring more frequently in HGBL with MYC and BCL2 translocation than cases with MYC and BCL6 translocations or triple-hit tumours[20].
In one study[6], both HGBL with MYC and BCL2 translocations and triple-hit cases had a higher mutational load and more frequent mutations in BCL2, KMTD2, CREBBP, EZH2 and TNFRSF14 than DLBCL with isolated MYC translocation. These mutations are cardinal features of follicular lymphoma and are also commonly seen in DLBCL, NOS. In addition, BCL2 translocated cases harboured additional mutations (MYC, GNA13, TP53, P2RY8, PIM1, CCND3, B2M, EBF1 and S1PR2) associated with high-grade transformation of follicular lymphoma, suggesting a possible derivation from follicular lymphoma following acquisition of a MYC translocation.
Overall, HGBL with MYC and BCL6 translocation shows a different and more heterogenous mutation profile to those with MYC and BCL2 translocation. BCL10 and NOTCH2 mutations are most commonly enriched in MYC/BCL6 translocated cases[6].
As HGBL is a genetically heterogenous disease, a multitude of gene mutations have been identified at varying levels of prevalence. The table below summarises the most common mutations identified from a number of studies[6][9][20][21][22][23], including only those with a prevalence greater than 20% in the data analysed.
Oncogene/Tumor Suppressor/Other
Presumed Mechanism (LOF/GOF/Other; Driver/Passenger)
Prevalence (COSMIC/TCGA/Other)
BCL2 Oncogene GOF 57% (72/126)
KMT2D Tumour suppressor LOF 54% (68/126)
CREBBP Tumour suppressor LOF 47% (59/126)
MYC Oncogene GOF 42% (53/126)
GNAI2 Oncogene GOF 40% (2/5)
IGLL5 Not fully characterised 40% (8/20)
EZH2 Oncogene GOF 39% (49/126)
TNFRSF14 Tumour suppressor LOF 33% (35/106)
SOCS1 Tumour suppressor/oncogene LOF/GOF 29% (33/112)
FOXO1 Oncogene GOF 29% (34/117)
IRF8 Oncogene GOF 29% (28/97)
TP53 Tumour suppressor LOF 25% (27/106)
DTX1 Tumour suppressor LOF 25% (23/92)
XPO1 Oncogene GOF 25% (2/8)
PIM1 Oncogene GOF 25% (25/101)
GNA13 Tumour suppressor LOF 25% (26/106)
HIST1H1E Oncogene GOF 24% (24/101)
ID3 Tumour suppressor LOF 23% (7/31)
BCL7A Tumour suppressor LOF 20% (1/5)
C10orf12 Not fully characterised 20% (1/5)
P2RY8 Oncogene GOF 20% (18/92)
Although the role of epigenomics in HGBL specifically has been incompletely described, many of the genes most frequently mutated in HGBL have been shown to be epigenetic determinants in DLBCL. Such genes include EZH2, KMT2D and CREBBP, which encode proteins that are involved in two epigenetic switches at the promoter and enhancer regions of genes involved in the germinal centre reaction. These switches regulate the movement of germinal centre B-cells between the dark and light zones of the germinal centre and require the addition or removal of specific histone post-translational modifications to up- or down-regulate the target gene.[24]
BCL6 is an important regulatory gene, repressing, often in combination with EZH2, the expression of a multitude of genes involved in cell cycle regulation whilst affinity maturation is ongoing. EZH2 encodes a histone methyltransferase which affects H3K27 methylation and its most common gain-of-function mutation has been shown in mouse models to cause a global increase of H3K27 trimethylation but with accompanying decreased expression of H3K27me3 at multiple loci[25]. When there is constitutive expression of BCL6 and a concurrent EZH2 mutation driving the repression of the promoter region of a common target gene, such as is sometimes observed in DLBCL, such repression may become permanent, leading to an oncogenic state.[24]
Similarly, inactivating CREBBP mutations within germinal centre B-cells prevent enhancer reactivation and, due to the role of CREBBP in acetylation of BCL6 and p53, impairs the cells' ability to regulate these genes. Thus, inactivating CREBBP mutations can trap cells in the germinal centre reaction, being unable to differentiate whilst being exposed to mutagenic and therefore potentially oncogenic conditions.[24] CREBBP and EP300, both histone acetyltransferases, are frequently mutated in DBLCL and mutations have been shown to promote oncogenesis by both inducing H3K27 deacetylation and activating the NOTCH signalling pathway, which is critical to the regulation of B-cell proliferation, migration and survival in lymphoma[26].
KMT2D mutants promote lymphomagenesis in part by impeding H3K4 methylation, driving enhanced proliferation in germinal centres and impeding terminal differentiation of B cells[27]. The extent to which KMT2D loss promotes lymphomagenesis appears to be affected by dysregulation of the expression of a number of other genes, including BCL2 and AICDA. KMT2D loss, in combination with increased BCL2 expression, has been shown in mouse models to increase lymphoma incidence from that of mice with wild type KMT2D, and the effect is greater for those with homozygous deletions[28][27]. Similarly the overexpression of AICDA, which encodes activation-induced cytidine deaminase (AID), an enzyme involved in somatic hypermutation, class switch recombination and gene conversion in the process of immunoglobulin diversification, has been shown in mice models to be associated with increased lymphoma incidence only in combination with KMT2D loss, and to be associated with more aggressive phenotypes than tumours with KMT2D deletion alone[27].
MYC is a proto-oncogene located at chromosome 8q24.2 which has been implicated in a variety of human cancers through its role as a regulator of multiple functions including cellular proliferation, DNA and protein synthesis and metabolism[29]. In the process of B cell maturation, MYC is involved in multiple different intracellular pathways governing angiogenesis, differentiation and metabolism[30]. MYC, not normally expressed by naïve B cells, is upregulated upon antigen stimulation and is crucial for germinal centre development, but is then subsequently suppressed by BCL6 and BLIMP1[31]. MYC translocation leads to increased MYC expression compared to non-translocated cases, regardless of translocation partner[32]. Translocation of MYC to an immunoglobulin locus leads to overexpression of the MYC protein due to IG promoter driven constitutively active transcription[33]. MYC expression in lymphoma promotes cell proliferation and induces genomic instability[33][34], however whilst MYC contributes to oncogenic changes, it can also paradoxically promote apoptosis and increase the expression of tumour suppressor TP53[35][30]. MYC overexpression in isolation is insufficient to promote lymphomagenesis[35][30], and MYC translocation is postulated to occur as a secondary genetic abnormality contributing to oncogenesis and an aggressive phenotype[1][30].
BCL2, an oncogene at chromosome 18q21.3, acts to inhibit apoptosis to maintain cellular viability, but is, in normal cells, itself downregulated by the BH3 family of proteins[17]. BCL2 overexpression resulting from chromosomal translocation confers apoptosis resistance to B-cells and allows them to proliferate within the germinal centre in which the BCL2 protein is not normally expressed[36]. BCL2 dysregulation acts synergistically with increased MYC translation to drive oncogenesis[17].
BCL6, located on chromosome 3q27.3 encodes a protein which suppresses the activity of P53, MYC and BCL2 and thus acts as a transcriptional repressor, contributing to the regulation of activation, differentiation and apoptosis in the germinal centre reaction[35][37][38]. In normal B-cell development, expression of the BCL6 protein is restricted to the germinal centre stage of differentiation[38]. Chromosomal translocations of BCL6 involve promoter substitution, where heterologous promoters from other chromosomes are relocated to the 5' end of the BCL6 gene[38]. Commonly, these promoters show persistent activity in post germinal centre B-cells, causing abnormal BCL6 expression by prevention of its physiological downregulation[38]. It is postulated that deregulated BCL6 expression contributes to lymphomagenesis by promoting a tolerance to DNA damage and hence oncogenic mutations[38].
Histologically, HGBL with MYC and BCL2 and/or BCL6 rearrangements is often indistinguishable from other high-grade lymphomas and the only method to ensure detection of all cases is universal investigation of DLBCL, NOS by MYC FISH with further testing for BCL2 and BCL6 translocations where MYC rearrangement is detected[1][2][17][39]. In environments with restricted resources, limiting screening to GCB subtype tumours would limit FISH testing to 50-62% of the DLBCL population, whilst still detecting >99% of tumours with MYC and BCL2 translocation[2].
Use of a MYC break-apart probe or IG/MYC dual fusion probe as the sole method of detection of MYC rearrangement has the potential to yield false-negative results in cases of 8q24 breakpoints occurring very close to the MYC gene region and non-IG MYC-rearrangement partners, respectively, and concurrent use of both break apart and IGH/MYC dual fusion probes is therefore recommended if possible[2][15][40][41][42]. Use of IGL/MYC and/or IGK/MYC dual fusion probes can follow, if required, to confirm the presence or absence of an IG fusion partner, which has implications for prognostication.
There are, however, limitations to FISH testing. A subset of HGBCL DH/TH harbour MYC and/or BCL2 rearrangements that are cryptic to FISH, for example via cryptic enhancer insertions near MYC of insufficient size to separate the break apart probes sufficiently for detection by FISH[40]. Such cases, identified via whole genome sequencing, were in one study found to account for 19% of all HGBL DH/TH tumours, with the authors recommending the use of gene expression profiling rather than FISH to identify HGBL DH/TH cases[40]. Furthermore, false-positive or false-negative FISH results can occur due to probe type or different numbers of malignant lymphoid cells in different specimens (eg BM aspirate vs FFPE tissue) as well as inter-observer variability[5].
Several authors[21][22][43][23] have proposed refined molecular subtypes of DLBCL based on gene expression profiling and/or mutation status, within which subtypes not all tumours are double- or triple- hit on the basis of FISH. In addition to overcoming translocations cryptic to FISH, several of these gene signatures have been shown to provide additional information on prognosis with one study showing that double hit lymphomas lacking the molecular high grade signature showed outcomes no worse than other germinal centre B-cell like cases[23].
In general, patients with germinal centre B type DLBCL have been shown to have a better prognosis than those with ABC-type tumours[15]. However, despite the fact that the majority of HGBL DH/TH tumours are of GCB subtype, concurrent MYC and BCL2 and/or BCL6 rearrangement confers significantly worse outcomes than tumours without concurrent translocations[3][5][12][15][16], with median progression free and overall survival of approximately 10 and 22 months, respectively, despite treatment[3][8]. The extremely poor outcomes in these patients are postulated to result from the synergistic dysregulation of both genes, leading to MYC-induced growth promotion and inhibition of apoptosis resulting from BCL2 rearrangement[3]. Amongst HGBL DH/TH patients, advanced stage, central nervous system involvement, leucocytosis and LDH>3 times the upper limit of normal are all associated with poorer outcomes[8] There appears to be no significant survival difference between patients with double hit (either BCL2 or BCL6) tumours and those with a triple hit[4][7][16].
The partner gene involved in MYC translocation also affects prognosis, with an IG partner gene conferring a significantly shorter progression free and overall survival[4][19]. Patients with double hit lymphoma with an IG-MYC translocation have significantly worse survival than patients with a non-IG partner gene and patients without a double hit, even in studies in which double hit has not shown to be independently associated with poorer outcomes overall. Several studies [4][16] have shown that, regardless of double or triple hit status, DLBCL patients with MYC rearrangement to an IG partner have a shorter overall survival than patients without MYC rearrangement and in one large study patients with double or triple hit lymphoma with MYC translocation to a non-IG partner did not show any significant difference in outcomes to patients with DLBCL without MYC rearrangement[16]. This reinforces the need for identification of the MYC translocation partner via appropriate FISH probe selection.
Further investigation of HGBL DH/TH via gene expression profiling in newer studies has reinforced that heterogeneity in outcomes exists amongst these patients, and that further sub classification via gene expression profiling and/or mutation analysis may be necessary to provide accurate prognostication.
Song et al[21] in a study of 87 cases of de novo DLBCL of germinal centre type treated with R-CHOP defined a subset of cases as "double-hit" on the basis of gene expression profiling (DHsig+), with most but not all cases showing double- or triple-hits on FISH. In this cohort, patients with DHsig+ and TP53 mutation had the worst overall and progression free survival, with good overall survival in DHsig+ patients without TP53 abnormalities. These mutations have been postulated to lead to a highly aggressive phenotype through evasion of apoptosis driven by BCL2 in the absence of TP53 mediation[20].
First-line treatment for HGBL is rituximab in combination with intensive chemotherapy, most commonly CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) with or without CNS prophylaxis[39]. Some studies have shown intensive induction regimens such as R-EPOCH to be associated with an improved response rate and progression free survival[8][11]. In vitro studies of novel targeted agents such as BET inhibitors both alone and in combination with BCL-2 and MDM2-p53 inhibitors have shown promising results[44] and further investigation of targeted therapies are needed to improve the otherwise dismal overall prognosis of these tumours.
There is currently no known familial association.
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↑ 21.0 21.1 21.2 Song, Joo Y.; et al. (2021-03-15). "Double-hit Signature with TP53 Abnormalities Predicts Poor Survival in Patients with Germinal Center Type Diffuse Large B-cell Lymphoma Treated with R-CHOP". Clinical Cancer Research. 27 (6): 1671–1680. doi:10.1158/1078-0432.CCR-20-2378. ISSN 1078-0432.
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↑ 23.0 23.1 23.2 Sha, Chulin; et al. (2019-01-20). "Molecular High-Grade B-Cell Lymphoma: Defining a Poor-Risk Group That Requires Different Approaches to Therapy". Journal of Clinical Oncology. 37 (3): 202–212. doi:10.1200/JCO.18.01314. ISSN 0732-183X. PMC 6338391. PMID 30523719. CS1 maint: PMC format (link)
↑ 24.0 24.1 24.2 Bakhshi, Tanner J.; et al. (2020-12). "Genetic and epigenetic determinants of diffuse large B-cell lymphoma". Blood Cancer Journal. 10 (12). doi:10.1038/s41408-020-00389-w. ISSN 2044-5385. Check date values in: |date= (help)
↑ Souroullas, George P.; et al. (2016-06). "An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation". Nature Medicine. 22 (6): 632–640. doi:10.1038/nm.4092. ISSN 1546-170X. PMC 4899144. PMID 27135738. Check date values in: |date= (help)
↑ Huang, Yao-Hui; et al. (2021-01-11). "CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7-NOTCH-CCL2/CSF1 axis". Signal Transduction and Targeted Therapy. 6 (1). doi:10.1038/s41392-020-00437-8. ISSN 2059-3635.
↑ 27.0 27.1 27.2 Ortega-Molina, Ana; et al. (2015-10). "The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development". Nature Medicine. 21 (10): 1199–1208. doi:10.1038/nm.3943. ISSN 1546-170X. PMC 4676270. PMID 26366710. Check date values in: |date= (help)
↑ Zhang, Jiyuan; et al. (2015-09-14). "Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis". Nature Medicine. 21 (10): 1190–1198. doi:10.1038/nm.3940. ISSN 1078-8956.
↑ Cheah, Chan Yoon; et al. (2015-03). "A clinician's guide to double hit lymphomas". British Journal of Haematology. 168 (6): 784–795. doi:10.1111/bjh.13276. Check date values in: |date= (help)
↑ 30.0 30.1 30.2 30.3 Korać, Petra; et al. (2017-04-04). "Role of MYC in B Cell Lymphomagenesis". Genes. 8 (4): 115. doi:10.3390/genes8040115. ISSN 2073-4425. PMC 5406862. PMID 28375188. CS1 maint: PMC format (link)
↑ Karube, Kennosuke; et al. (2015-04). "MYC alterations in diffuse large B-cell lymphomas". Seminars in Hematology. 52 (2): 97–106. doi:10.1053/j.seminhematol.2015.01.009. ISSN 1532-8686. PMID 25805589. Check date values in: |date= (help)
↑ Bertrand, P.; et al. (2007-03). "Mapping of MYC breakpoints in 8q24 rearrangements involving non-immunoglobulin partners in B-cell lymphomas". Leukemia. 21 (3): 515–523. doi:10.1038/sj.leu.2404529. ISSN 0887-6924. PMID 17230227. Check date values in: |date= (help)
↑ 33.0 33.1 Sesques, Pierre; et al. (2017-01-19). "Approach to the diagnosis and treatment of high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements". Blood. 129 (3): 280–288. doi:10.1182/blood-2016-02-636316. ISSN 0006-4971.
↑ Meyer, Natalie; et al. (2008-12). "Reflecting on 25 years with MYC". Nature Reviews Cancer. 8 (12): 976–990. doi:10.1038/nrc2231. ISSN 1474-175X. Check date values in: |date= (help)
↑ 35.0 35.1 35.2 Riedell, Peter A.; et al. (2018-12-15). "Double hit and double expressors in lymphoma: Definition and treatment". Cancer. 124 (24): 4622–4632. doi:10.1002/cncr.31646. ISSN 0008-543X.
↑ Tomita, Naoto (2011). "BCL2 and MYC Dual-Hit Lymphoma/Leukemia". Journal of Clinical and Experimental Hematopathology. 51 (1): 7–12. doi:10.3960/jslrt.51.7. ISSN 1880-9952.
↑ Basso, Katia; et al. (2010). "BCL6: master regulator of the germinal center reaction and key oncogene in B cell lymphomagenesis". Advances in Immunology. 105: 193–210. doi:10.1016/S0065-2776(10)05007-8. ISSN 1557-8445. PMID 20510734.
↑ 38.0 38.1 38.2 38.3 38.4 Basso, Katia; et al. (2012-04-13). "Roles of BCL6 in normal and transformed germinal center B cells". Immunological Reviews. 247 (1): 172–183. doi:10.1111/j.1600-065x.2012.01112.x. ISSN 0105-2896.
↑ 39.0 39.1 Chaganti, Sridhar; et al. (2016). "Guidelines for the management of diffuse large B-cell lymphoma". British Journal of Haematology. 174 (1): 43–56. doi:10.1111/bjh.14136. ISSN 1365-2141.
↑ 40.0 40.1 40.2 Hilton, Laura K.; et al. (2019-10-31). "The double-hit signature identifies double-hit diffuse large B-cell lymphoma with genetic events cryptic to FISH". Blood. 134 (18): 1528–1532. doi:10.1182/blood.2019002600. ISSN 0006-4971. PMC 6839951. PMID 31527075. CS1 maint: PMC format (link)
↑ Muñoz-Mármol, Ana M; et al. (2013-09). "MYC status determination in aggressive B-cell lymphoma: the impact of FISH probe selection". Histopathology. 63 (3): 418–424. doi:10.1111/his.12178. Check date values in: |date= (help)
↑ May, Philippa C.; et al. (2010-04). "Detection of cryptic and variant IGH-MYC rearrangements in high-grade non-Hodgkin's lymphoma by fluorescence in situ hybridization: implications for cytogenetic testing". Cancer Genetics and Cytogenetics. 198 (1): 71–75. doi:10.1016/j.cancergencyto.2009.12.010. Check date values in: |date= (help)
↑ Ennishi, Daisuke; et al. (2019-01-20). "Double-Hit Gene Expression Signature Defines a Distinct Subgroup of Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma". Journal of Clinical Oncology. 37 (3): 190–201. doi:10.1200/JCO.18.01583. ISSN 0732-183X. PMC 6804880. PMID 30523716. CS1 maint: PMC format (link)
↑ Deng, Manman; et al. (2021-02). "Aggressive B-cell Lymphoma with MYC/TP53 Dual Alterations Displays Distinct Clinicopathobiological Features and Response to Novel Targeted Agents". Molecular cancer research: MCR. 19 (2): 249–260. doi:10.1158/1541-7786.MCR-20-0466. ISSN 1557-3125. PMC 8092941 Check |pmc= value (help). PMID 33154093 Check |pmid= value (help). Check date values in: |date= (help)
Retrieved from "https://ccga.io/index.php?title=High-Grade_B-cell_Lymphoma_with_MYC_and_BCL2_and/or_BCL6_Rearrangements&oldid=11008"
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MainAll NewsDefense/Middle EastArab Terrorist?s Wife Used Baby to Hide Grenade
Arab Terrorist?s Wife Used Baby to Hide Grenade
Soldiers arrested a terrorist's wife who held her baby to hide a grenade. In the same house, troops found a suitcase of explosives. The IDF also killed four other terrorists who attacked them.
Tzvi Ben Gedalyahu, 23/10/05 07:13 | updated: 22:44
Haruv Battalion soldiers searched a house in a village near Shechem early Saturday after receiving reports that ammunition was hidden there, according to Lt.-Col. Arik Chen. They discovered 10 kilograms (22 pounds) of explosives in a suitcase and arrested five terrorists.
Noticing that Aziza Jawabra, the wife of one of the terrorists, was holding her one-month-old baby in an unusual manner, the troops searched her and found a grenade in a jacket she was wearing.
"To see a woman using her baby to hide a grenade is not typical," Lt.-Col. Chen said. "She didn't have much to say," he added, except to deny knowing that the grenade was in the jacket. After soldiers arrested the terrorists, sappers blew up the explosives, which destroyed the three-story building.
"I can firmly confirm that an attack against soldiers and civilians has been thwarted. Terror activities have not stopped for a minute," Lt.-Col. Chen added.
In separate incidents over the weekend, the IDF killed four Arab terrorists. Soldiers opened fire at two terrorists who were placing an explosive device on a road near the community of Ne've Tzuf Saturday night. One terrorist was killed and the other escaped.
Friday night, soldiers killed two Arab terrorists who shot at their base near the village of Anabta near Tulkarm, which overlooks the high-speed Highway 6, about five miles east of Netanya. One of the terrorists was armed with a hunting rifle. Soldiers also killed a terrorist who shot at them while on patrol near Shechem.
Arabs identified the Shechem terrorist as a 21-year-old member of the Popular Front for the Liberation of Palestine (PFLP).
Troops also arrested 11 Hamas terrorists in Hevron.

redpajama_set_name: RedPajamaCommonCrawl


Photos: Matisse outreach "Art Bus"; Ambassador Barbier at Leitsibolo School, 15 June 2016.
An Art Bus is visiting Soweto schools as the Rhythm and Meaning opening nears.
The French modernist master Henri Matisse drew inspiration from African art and in turn inspired key South African artists, and this genius will be shared with learners from 46 previously disadvantaged schools ahead of the Henri Matisse|Rhythm and Meaning exhibition at Johannesburg's Standard Bank Gallery from 13 July to 17 September 2016.
This month, an Art Bus will be travelling to 10 Soweto primary schools, where 10 student teachers from the University of Johannesburg will be conducting morning art workshops. As part of the outreach programme, learners will also be presented with exquisite educational workbooks, inspired by Matisse's artworks and motifs and designed specially for this exhibition.
Between 1 and 21 June, the Art Bus will visit Bafikile, Hlakaniphani, Moriting, Sbongile, Emseni, Itemogele, Mochochonono, Leitsibolo, Molaetsa and Tshebidisanong primary schools, bringing the magic of art to life for young minds.
In addition, for the duration of the Rhythm and Meaning exhibition, learners from 20 more township schools will be brought to the Standard Bank Gallery for guided walkabouts. They will also be treated to a cut-out workshop, echoing one of the techniques for which Matisse is renowned and which he called "painting with scissors".
Teachers from an additional 16 Soweto primary schools will be mentored in paper cut-out art, in order to share this skill with their young wards.
Learners from all the primary schools will receive the beautiful workbooks, crammed with stimulating creative activities.
The workbooks refer in depth to the central work in the exhibition, the 20 impressions for the prints in Matisse's book Jazz, while also drawing attention to his distinctive use of colour and his impact on South African contemporary artists such as Walter Battiss and Sam Nhlengethwa. The interactive exercises are themed around Matisse's works (many of which are featured in the exhibition), including the drawing of masks and the designing of a "pop-up" room.
Wilhelm van Rensburg, co-curator of the educational component of the Matisse exhibition, explains: "The workbook develops an intellectual understanding of art concepts, and encourages practical art-making skills. For example, we use Matisse's famous cut-out work, The Snail (Tate Modern, London), which he based on the spiral shape of the 'z' in the word 'Jazz' that he wrote out by hand, as the basis of a series of cut-out animals and insects that the learners do practically in class."
Adds Standard Bank educational officer Joseph Rampa, who is also leading this schools initiative: "In keeping with our long-standing commitment to arts development, Standard Bank is excited about bringing Matisse's artistry to Soweto's schoolchildren.
"Matisse is known for boldly forging a new 20th-century visual language, and his pioneering spirit is being explored in a lively and vivid way through this outreach programme. We hope to cultivate in the learners – and other children who attend the exhibition – an interest in and appreciation of art that will hopefully take root and endure, and go on to greatly enrich their future cultural lives."
The Henri Matisse|Rhythm and Meaning exhibition is co-curated by Patrice Deparpe, Director of the Musée Matisse in Le Cateau-Cambrésis, France, and Federico Freschi, Executive Dean of the Faculty of Art, Design and Architecture at the University of Johannesburg.
It marks the first major showcase of Matisse's art on the African continent, and is the fourth exhibition of important 20th-century European modernists to be held at the Standard Bank Gallery, which has previously hosted monographic exhibitions focusing on the work of Marc Chagall, Joan Miró and Pablo Picasso.
The exhibition will include a number of paintings, drawings, collages and prints covering all the dominant themes in the artist's body of work, from his early Fauvist years, through his interest in exoticism and orientalism, to the paper cut-outs that he produced in the last years of his life.
Henri Matisse|Rhythm and Meaning is presented by Standard Bank in partnership with the Embassy of France in South Africa and the French Institute of South Africa, and with the support of Matisse Museum Le Cateau-Cambresis, Air France, Total and Air Liquide.


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LawFacts
A legal information resource from Legal Aid Ontario
If you have a legal question, and you live in Ontario, this site is for you.
LawFacts provides in-depth legal information and resources.
What is a joint submission?
A joint submission is when both the Crown and the offender's lawyer (or duty counsel) agree on the sentence they are asking the judge to give. In most cases, a joint submission will have been agreed to by lawyers in a resolution meeting.
However, even when the lawyers have a joint submission, the judge does not necessarily have to agree with them and can still give a different type or length of sentence. In many cases, the judge will agree with the joint submission, but the judge always makes the final decision on a sentence.
What's the difference between having charges withdrawn or stayed?
I am making a claim when I arrive in Canada
Conditional sentence ("house arrest")
Intermittent sentence ("weekends")
Suspended sentence
What do I do if...?
I'm asked to be a surety?
I have a bail question?
I want to plead guilty?
I don't have a lawyer?
How do I contact LAO?
Email us: info@lao.on.ca
Follow us on . . .
Family Law Information Program (FLIP)
Your Legal Rights (CLEO)
This section has been created as a public service by Legal Aid Ontario. Every reasonable effort has been made to ensure that the information presented is current and accurate. However, users of this section should verify the information before making decisions or acting upon it. This section contains general legal information. It is not intended to be used as legal advice for a specific legal problem.


Download and/or print a copy of the official Syrian Visa Application (using Adobe Acrobat) from the Syrian Embassy in the U.S.
The Fardoss tower hotel is located at the center of Damascus, the pearl of ancient civilization, which is surrounded by business offices, ministries and market. The old city, Kassioun mountain and the gardens of Barada river are the wonderful sights from the hotel.
Situated in the middle of business and shopping areas, Fardoss offers you all the advantages of a four star hotel with the ultimate comfort. Its �homey� atmosphere makes our hotel the perfect one for business travelers and families.
This is the site where St. Simeon lived on top of a pillar for fourty-two years. Fourty-two years under the blazing sun, in the bitter cold, and exposed to all the mountain winds!
He is a shepherd from Northern Syria who became a monk as the result of a revelation in a dream. There is only a stump of the column left, some two or three meters high. Shortly after the death of the holy man the most beautiful church in the East was built on the ridge of the hill where he had taken up "residence".
The lay-out, centering on the famous column, was original. Four basilicas, arranged in the shape of a cross, opened onto a sort of octagon covered by a dome; in the center stood the sacred pillar. This Citadel offers a view of some of the 300 dead towns of the Byzantine era of Northern Syria.


Systel offers customers outstanding printers, multifunction devices and other pieces of office equipment. Of course, this hardware wouldn't be worth much without the cartridges that enable you to make prints. For that reason, we also offer a variety of energy-efficient, eco-conscious supplies. These products will give you clean, sharp documents and images with minimal waste.
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Learn why Systel encourages customers to choose only original equipment manufacturer (OEM) supplies.
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text:
Q: Can we make a element optional or mandatory depending on value of any other element in XSD In XSD i have one element x which takes values (a,b)
There is another element y
Is there any way using XSD so that  i can make y as mandatory when value of x is b and optional if value of x is a

A: Have a look at XML Schema Part 0: Primer Second Edition, section 2.2.1 Occurrence Constraints.
It says:

In general, an element is required to appear when the value of minOccurs is 1 or more. The maximum number of times an element may appear is determined by the value of a maxOccurs attribute in its declaration. This value may be a positive integer such as 41, or the term unbounded to indicate there is no maximum number of occurrences. The default value for both the minOccurs and the maxOccurs attributes is 1.

Because an attribute value cannot be deduced from other schema content in XML Schema, what you want to achieve is impossible (with XML Schema).
(I don't know if Relax NG can do this, but you may investigate if it supports such content-dependent definitions.)

redpajama_set_name: RedPajamaStackExchange


text:
11 Martin Lawrence & Tisha Campbell Reinforce Their Friendship On Instagram
Young Money Entertainment Sued For Not Paying Producers' Royalties
August 26, 2012 | 10:30 AM
by RomanCooper
In what is now a regular occurrence, two producers are suing Lil Wayne's Young Money Entertainment for shady business dealings.
Andrew "Drew" Correa and Marcos "Infamous" Rodriguez have filed federal lawsuits against Young Money, reports TMZ.
In the first suit, Correa claims he had a deal with YME in 2008 to produce music that ended up being on Tha Carter III, Re-Birth, I Am Not a Human Being, and Priceless.
Correa says he was paid some royalties, but then the checks stopped coming.
In the second suit, Rodriguez claims that in 2007, he agreed to produce for YME and that his work was used on Tha Carter III, Re-Birth, We Are Young Money, Tha Carter IV, and Priceless, and that his royalty payments stopped coming as well.
This appears to be a pattern with Young Money, as In the past producers Deezle, Bangladesh, Jim Johnson, and David Kirkwood, and Play-N-Skillz have sued for unpaid royalties.
RELATED: The Hip Hop Week In Review: Lil Wayne Blasts New York, LL Cool J Stops Burglar


Practical information on running profiler traces, primarily as server-side traces, to get you started with the basics.
SQL Server tracing is essential for troubleshooting performance issues, yet it can put loads on your server that would cause noticeable slowness, capture so much information that it fills the drive, and I've even seen it cause a cluster failover more than once. With a tool this powerful you just need to know how to use it before you use it. It's almost like the idea where companies want their entry-level people to have a year of experience.
There is one trace I'd like to see on every server, preferably as a startup proc or a job that starts automatically when SQL Agent starts. It doesn't matter how you do it, if you want me to be happy you'll tell me this was running for at least 24 hours before you had a performance incident. All I'm looking for is RPC:Completed and SQL:BatchCompleted with a reasonable filter of duration over 10 seconds.
If you've never used Profiler before, here's a quick overview to make the server-side trace I'm using. Leave the first screen at the defaults, with the possible exception of changing the template to blank. Select RPC:Completed and SQL:BatchCompleted and set the Duration filter to greater than or equal to 10,000 ms which you can get to using the "Column Filters…" button. You can collect all columns if you want to, it won't hurt with these events although there are some columns that won't help.
Run the trace, then you can export it to a script. I'm not happy that you have to run it first, but in the end this is either something that doesn't affect the server at all or something I run on a dev server that's at the same patch level.
There, you have the basic script to start the server-side trace. You still need to tweak it a bit before you can use it, but the hard part is done. Everything highlighted in yellow was changed by me. The default max file size was changed from 5 MB to 25 MB because I view 25 to 50 MB to be the range that's not annoyingly small or too big to move around or send to someone easily. The second parameter of sp_trace_create is set to 2 to enable rollover files, the third parameter is set to my output file sans an extension, and the last parameter is added to say how many output files there are.
This is done as a server-side trace for a couple reasons. Profiler needs to stay open to keep collecting data, SQL Server has to send the data to Profiler which is usually across the network, then the trace data is held in memory. None of these are a problem for a properly filtered short-term trace. This is properly filtered, but I'm really hoping everyone will run this long-term.
I owe you another blog post on querying traces, then we can move in to putting it all together with where to start when a user makes their favorite statement to you…"The server is running slow".


text:
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GitLab is a single application for the entire software development lifecycle. From project planning and source code management to CI/CD, monitoring, and security.
GitLab Inc. is a company based on the GitLab open-source project, helping developers collaborate on code to build great things and ship on time. We are an active participant in our global community of customers and contributors, trying to serve their needs and lead by example. We have one vision: everyone can contribute to all digital content, and our mission is to change all creative work from read-only to read-write.
We value results, transparency, sharing, freedom, efficiency, frugality, collaboration, directness, kindness, diversity, boring solutions, and quirkiness. If these values match your personality, work ethic, and personal goals, we encourage you to visit our primer to learn more. Open source is our culture, our way of life, our story, and what makes us truly unique.
about.gitlab.com
Actifio virtualizes the data that's the lifeblood of businesses in more than 30 countries around the world. Its Virtual Data Pipeline™ technology enables businesses to manage, access, and protect their data faster, more efficiently, and more simply by decoupling data from physical storage, much the same way a hypervisor decouples compute from physical servers. Actifio is the world's leading Enterprise Data-as-a-Service platform. It enables thousands of companies around the world deliver their data just as they deliver their applications and infrastructure… as a service available instantly, anywhere. An enterprise-class software platform powered by patented Virtual Data Pipeline™ technology, Actifio frees data from traditional infrastructure to accelerate adoption of hybrid cloud, build higher quality applications faster, and improve business resiliency and availability.
www.actifio.com
Google Cloud is a set of solutions and products, including GCP and G Suite, that can help you solve your toughest business challenges. Google Cloud Platform : Grow your business with our secure storage, powerful compute, and integrated data analytics products. G Suite: Work as a team with enterprise-ready apps like Gmail, Docs, and Drive, all powered by Google AI. Build, innovate, and scale with Google Cloud Platform. Collaborate and be more productive with G Suite. See what's possible with Google Cloud.
cloud.google.com
Brennan IT supports and manages the ICT infrastructure of more than 1,000 Australian companies, helping make their lives easier. It's why Brennan IT has been ranked Australia's No. 1 Managed Services Provider for nine consecutive years. With capability spanning hybrid IT, networking, end user services and security, our promise is to continually innovate and evolve to deliver on the needs of our clients.
It all started with a realisation that Australian businesses could be so much more — if only they could get a handle on their IT.
Our founder, Dave Stevens, knew there had to be a better way for these businesses to get the benefits of technology. He set out to find a solution — a chance for businesses to get away from the stress of IT management altogether and simply focus on what they do best: their business.
That solution is Brennan IT.
www.brennanit.com.au
ForgeRock's Identity and Access Management Solutions helps their customers deepen their relationships with their consumers (CIAM), and improve the productivity and connectivity of their employees and partners (IAM).
Our technology enables great digital experiences between people and their things.
www.forgerock.com/
Founded in 2012 by former McAfee Global CTO Stuart McClure and Chief Scientist Ryan Permeh, Cylance is revolutionizing cybersecurity. Our products and services use artificial intelligence and machine learning to proactively prevent, rather than reactively detect the execution of advanced persistent threats and malware.
Our technology is deployed on over ten million endpoints and protects hundreds of enterprise clients worldwide including Fortune 100 organizations and government institutions. Our flagship product, CylancePROTECT®, is the world's first next-generation antivirus built on artificial intelligence and machine learning. With the introduction of CylancePROTECT Home Edition, that same groundbreaking enterprise technology is now available for corporate employees to use at home to protect their and their families' personal devices.
www.cylance.com
At AppDynamics, our Application Intelligence Platform empowers today's software-defined businesses with the ability to proactively monitor, manage, and optimize the most complex software environments. Because we start with user interactions, our platform is able to dynamically collect millions of performance data points across your applications and infrastructure. We then apply intelligence to instantly identify performance anomalies, enable automatic fixes and continuously measure business impact. And all this happens in real time, in production, with cloud or on-premise deployment flexibility. So even in the most dynamic production environments, you can know more and know it faster. It's more than monitoring—it's true Application Intelligence.
For more information, visit www.appdynamics.com.
www.appdynamics.com
BlackBerry secures, connects and mobilizes the enterprise. To manage today's enterprise of things, BlackBerry provides a software platform that enables and manages security, mobility and communications between and among hardware devices, programs, mobile apps and the internet of things. Founded in 1984 and based in Waterloo, Ontario, BlackBerry operates in North America, Europe, Middle East and Africa, Asia Pacific and Latin America. The Company trades under the ticker symbols "BB" on the Toronto Stock Exchange and "BBRY" on the NASDAQ. For more information, visit www.BlackBerry.com.
www.BlackBerry.com
Pyxle is a digital transformation and technology company that provides enterprise solutions and services to our global customer base. A trusted name since 2003, Pyxle develops transformation strategies to drive revenue and improve operational excellence through technology services, software & cloud development, data & analytics services and managed IT services.
Pyxle is proud to be part of the Elovate Group, a cluster of Tavistock Group companies that offers our partners value through end to end technology solutions across hardware, software, marketing and analytics.
The Pyxle family is a team of problem-solvers driven by a passion for excellence and a desire to help customers succeed. We're looking for self-motivated people who share that same drive and who are eager to combine teamwork with technology to deliver incredible results.
pyxle.io
VidCorp is the world's first online video platform designed to give businesses of all sizes the tools needed to leverage effortlessly the power of video to achieve enviable commercial outcomes.
VidCorp exists to deliver – communications, engagement and, most importantly, results.
Our vision is to craft the smartest, simplest and most agile online video platform globally.
www.vidcorp.com
Domo optimizes your business by connecting you to the data, people, and expertise you need to improve business results.
Domo helps every employee – from the CEO to the front line worker – optimize business performance by connecting them to the right data and people they need to improve business results.
The company is backed with more than $500 million from the world's best investors and is led by a management team with tenure at the world's most well-known technology companies.
www.domo.com
Thales e-Security is the leader in advanced data security solutions and services, delivering trust wherever information is created, shared or stored. We ensure that company and government data is secure and trusted in any environment – on premise, in the cloud, in data centers and in big data environments – without sacrificing business agility. Security doesn't just reduce risk, it's an enabler of the digital initiatives that now permeate our daily lives – digital money, e-identities, healthcare, connected cars and with the internet of things (IoT) even household devices. Thales provides everything an organization needs to protect and manage its data, identities and intellectual property and meet regulatory compliance – through encryption, advanced key management, tokenization, privileged user control and meeting the highest standards of certification for high assurance solutions. Security professionals around the globe rely on Thales to confidently accelerate their organization's digital transformation. Thales e-Security is part of Thales Group.
www.thalesesecurity.com
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APAC CIOoutlook is a print magazine that aims to provide a platform for CIOs, CTOs and other senior levels IT buyers and decision makers along with CXOs of solution providers to share their experiences, wisdom and advice with enterprise IT community of APAC countries. We promote our unique 'learn from our peers approach' in the Asia Pacific region. From enterprise applications to the leading trends in big data, mobile computing, security and the Cloud, APAC CIOoutlook delivers practical, actionable information from senior practitioners in the trenches. We leverage our extensive peer-to-peer network, among leading technology executives, to bring their experience and the best practices to other members of the CIO community in Asia Pacific countries. We also identify and profile emerging companies providing cutting edge solutions to enterprises in APAC. For every technology and every industry vertical, our research team has access to and has deep background research done on hundreds of vendors providing solutions in APAC. Published from the hub of technology, Silicon Valley, USA.
www.apacciooutlook.com
ITUpdate is an online publication of IT vendor releases. Its aim is to bring you the very latest releases directly from the vendor. Currently, it has listed the Top 250 leading Global IT vendors in the market today. ITUpdate is owned by Inform Group Pty Ltd and Australian Pty Ltd company ABN: 63 103 190 781. Inform Group Pty Ltd has been successfully working in the IT industry for nearly 20 years. Our head office is in Sydney, Australia and we have additional offices in Melbourne, Singapore, and Manila.
www.itupdate.com.au
Business Chief, formally known as Business Review Magazines, is a media brand fit for the digital age, providing cutting-edge content tailored for company executives, business pioneers and industry thinkers.
Divided into eight separate regional titles, Business Chief tells the stories that matter to business leaders and professionals on their way to the top. Through our expertly-crafted digital magazines, websites, videos and social media, those stories reach the right people.
Our flagship features are the Leadership Showcases; exclusive interviews with key decision-makers at some of the biggest companies on the globe, documenting their journeys to business transformation and the lessons they've learned along the way.
With further themes focused on technology, talent and sustainability, Business Chief has insight on the trends that matter to C and V-level executives, while also delivering consumer-friendly lifestyle content to reflect their interests and wider ambitions.
On top of all that and more, Business Chief showcases in-depth digital reports on companies every month, ensuring it covers every angle in the world of business.
www.businesschief.com
Gigabit is a digital information and media platform for executives and leaders, providing expert insight into the ever expanding space occupied by technology in business.
Packed with deep features and insight from key leaders in business, Gigabit content can be found online or via our exclusive digital magazine, distributed monthly to a select membership of industry leaders around the world.
Technological innovation is now an inescapable facet of business across all industries, and Gigabit serves up a diet of cutting-edge insight via exclusive interviews with CIOs, CTOs and Heads of IT from some of the world's most influential companies.
Gigabit is here to answer and, perhaps more importantly, ask the questions that enterprises need to answer in addressing the challenges and opportunities a dynamic and changing technological landscape represent.
www.gigabitmagazine.com
CISO MAG is the handbook for Chief Information Security Officer (CISO)s, CXOs, and every stakeholder of safe internet. To provide the cybersecurity experts key information and analysis to tackle the security challenges, EC-Council created CISO MAG, an information security magazine for best practices, trends, and news. For all the latest happening in cyber security space, visit our site: www.cisomag.com Follow us on LinkedIn for all the latest news & updates. Preview & Subscribe for our latest issue here
www.cisomag.com
Kevin Bloch, CTO, Cisco
"I am very impressed by the professionalism, the turn out of high calibre CIO's, and also the informality in terms of people socialising and expressing their ideas. It is a high quality show right from the get go! Great program also as it contains all the important issues that CIO's are facing at this time."
Tim Thurman, CIO, Australian Securities Exchange
"I enjoyed the personal one on ones. I was very selective when picking who I was going to meet with, so this was so great to have the opportunity to pick who I was going to meet, and the 'meets' so far have been really good. I plan to carry on the conversations down the road. I very much recommend this event."
Steve Godbee, CIO ANZ, IBM
"Excellent Event, Good Investment of time. One of my favourite aspects was the networking opportunities with both peers and vendors. Presentations were very good and on relevant topics. The one-to-one format is conducive to good discussions. Everyone I talked to had a great time."
Shane Lenton, CIO, Cue Clothing Company
"This has been a really great event. The content was very relevant, and the calibre of attendees has been fantastic. My favourite thing was the round-table discussions, the content discussed amongst peers has been very relevant and useful. I would certainly recommend this Summit."
The CIO Leaders Summit Australia is invitation only and intended for Australia's most senior IT leaders to gather for a strategic event in order to exchange knowledge and interact as one over a range of important issues facing the industry. The one-to-one meetings with leading supplier companies will also provide a wealth of knowledge and offer opportunities for all attending delegates, while the informal networking sessions promise to create a unique interactive forum.
Protecting a world powered by the cloud, data & software – Thales Brochure
Click to view the PDF […]
Applying Open Banking to Bring Agility, Cost Reduction, and a Focus on Quality
With customer experience being at the heart of every organisation's plans, businesses are increasingly working towards a dynamic platform to […]
Interview with Duncan Cavanough, Head of IT & Operations, AFL Telecommunications Australia
AFL Telecommunications Australia is part of AFL Global based in the US. AFL Global is subsequently owned by Fujikura Limited, Japan and employs […]
Everything you need to know about Digital Transformation, but were afraid to ask – Travers Stow
ROUNDTABLE DISCUSSION Travers Stow, Chief Information Officer, Sigma Healthcare Travers held a roundtable discussion that unravelled […]
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