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Robert M. Frendak
Robert M. Frendak, 84, passed away on January 6, 2021 from complications due to COVID-19. He was born in Elmira, NY on May 18, 1936 to Paul and Sue Frendak.
In his younger days, Bob lived and worked on the family farm on Lacy Road in Mandana. He was a member of the Skaneateles High School Class of 1955. Bob later worked as a carpenter at the Syracuse University Physical Plant, retiring in 1998 after 33 years of service. He was a lifelong communicant of Holy Trinity Lutheran Church in Skaneateles.
Bob enjoyed working in his wood shop, playing golf, watching SU basketball and the NY Yankees, square dancing with the Cayuga Cut-ups, and wintering in Winter Haven, FL.
Bob is survived by his beloved wife of over 39 years, Melissa; his sons, Rodney and Todd Frendak (Tammy), all of Skaneateles; his daughter Jessica Meyer of Auburn; and his grandchildren, Sierra and Trevor Frendak. He is also survived by his brother Paul (Beverly) Frendak of Georgia and sister Joyce Sholtes of Florida. Bob was predeceased by his parents; infant brother James; his first wife and the mother of his two sons, Dolores Horning; and infant daughter, Lisa.
No Calling hours a graveside service will be on Wednesday, January 13th at 11am at Lakeview Cemetery, Skaneateles.
Sending heartfelt condolences to the Robert M. Frendak family. So sorry to hear of Robert's passing. He was a faithful longtime member of Holy Trinity Lutheran Church. Praying that the family be comforted at difficult this time.
Sending my deepest sympathy to the family of Robert Frendak. Mr. Frendak and my late father, Bob Taylor, worked together at Syracuse University and Mr. Frendak did some work on our family home years ago. Mr. Frendak was a gifted carpenter and very kind man. He will be missed by all who knew him.
Carol and Jeff Mullen
Bob you were such a wonderful guy. You'll be deeply missed our friend. Best landlord we ever had.may Melissa and the whole family find strength and comfort in their time of sorrow.
Peter Connell
Melissa and Family!!
So sorry!! Sending prayers!
Dottie and Al Cook
We send our love and prayers to Missy and the whole family. Bob has been a cherished friend for years. He was one of the kindest and caring man we knew. We have many fond memories. Love you Bob.
Bob and Eileen Scarlata
We were so sorry to hear about Bob passing away. Keeping your family in our thoughts and prayers at this difficult time.
Our thoughts and prayers going your way What a gentle and kind man he was He would do anything to help anyone He will be greatly miss Missy and the whole family know he is a angel now watching over you all
maryalice vanvlack Peter Van Vlack
Our thoughts are with you and your family at this time sorry for your loss.
Patricia Woodruff
Todd and Rodney, I'm so sorry to hear of your father's passing.

redpajama_set_name: RedPajamaCommonCrawl


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russian warships under construction
2019 . BF. Eight of them will be built by project 20380. Last Update: 18, January, 2021 : Russian Navy 2021 : BF - Baltic Fleet, BSF - Black Sea Fleet, NF - Northern Fleet, PF - Pacific Fleet, CF - Caspian Flotilla : Class. By Brian McGleenon. During those exercises, the crews of the two corvettes dealt with the tasks of searching for, detecting and destroying a notional enemy's submarine with anti-submarine armament in interaction with the crews of Ka-27 helicopters, which operated from the vessels. 13. 5. Royal Navy warships monitor significant Russian presence close to UK waters 04 December 2020. THE Royal Navy has shadowed nine Russian warships stalking Britain's coast in the past two weeks. 14. In October 2018, India signed a contract to buy two of the under-construction Admiral Grigorovich class ships originally meant for the Russian … 'Despite the increase in Russian activity, both on the surface and underwater, we are always ready to respond.'. Air-Defense Guided Missile Destroyer Warship. He added that the most advanced Russian missile systems S-400 Triumph are currently on combat duty on the Novaya Zemlya archipelago. It is implemented on other warships under construction, including ice-class patrol ships of project 23550. Every move made by the Russians – a surfaced submarine, destroyer, corvette, patrol ship and their supporting tugs and supply ships – was watched closely by eight RN ships from the English … The contract for two frigates was expected, but the deal for a record batch of corvettes was a surprise. Peter Suciu is a Michigan-based writer who has contributed to more than four dozen magazines, newspapers and websites. The Sovershenny … The vessels have a steel hull and composite material superstructure, along with a bulbous bow and nine watertight subdivisions. NF. Higher expenditure led to an increase in numbers of ships under construction, initially focusing on submarines, such as the conventional Petersburg -class and nuclear Severodvinsk -class. The Russian Navy currently operates six of the Project 20380 multi-purpose guided missile corvettes, while two additional warships of the class are under construction. Under the deal, two frigates will be built at Russia's Yantar Shipyard on the Baltic coast (part of the United Shipbuilding Corporation) and the other two will be constructed at India's Goa Shipyard Limited (GSL). He is the author of several books on military headgear including A Gallery of Military Headdress. 1976. This list of active Russian Navy ships presents a picture which can never be fully … The two warships also conducted drills that included delivering a missile strike from the Uran anti-ship missile systems against the simulated enemy's naval groups with electronic missile launches. The force also has 48 warships under construction in India, including aircraft carrier INS Vikrant, four Scorpene submarines and the … RUSSIAN and Iranian warships have held joint naval drills in the Indian Ocean. The warships will reinforce the Russian blue-water fleet which currently operates ships built in 1980 - early 1990s. The discussion between the two nations' naval representatives went beyond a proposed drill, and during the meeting, the Russian and Indian delegations discussed bilateral interaction in the construction of Indian warships at Russian naval shipyards – while trials and testing would also be conducted at Baltic Sea ranges. The offshore patrol vessels are, after all, well suited to patrolling offshore and for surveillance work, not designed to go into combat against foreign warships. 6. On October 30, Russia celebrates the Founding Day of the Navy. CF. See more ideas about warship, naval, navy ships. India, Russia seal $500 million deal for construction of 2 frigates. India, Russia finalise USD 500 million deal for construction of 2 warships for Indian Navy 20 Nov, 2018, 06.33 PM IST. The corvette Soobrazitelny was shown to the public for the first time at the Fifth International Maritime Defence Show (IMDS-2011) in St. Petersburg. The agreement was signed between defence PSU Goa Shipyard Ltd and Russia's state-run defence major Rosoboronexport under the government-to-government framework for defence cooperation. Moscow is currently working to empower its fleets on the world seas and have a total of nine surface vessels with long-distance capacities under construction. Type 23 frigate HMS Northumberland, based at Devonport, watched the movements of Udaloy-class destroyer the Vice-Admiral Kulakov as it sailed north-west of the Outer Hebrides, off the west coast of Scotland. Russia should induct BrahMos missile: AK Antony 19 Feb, 2013, 02:46PM IST BrahMos has been pushing for the induction of the missile on under-construction Russian warships which are similar to Indian Navy's Talwar Class frigates. … There are more than 280 warships, submarines and warfare boats believed to be in active service with the Russian Navy, on reserve, or under construction, based on public reports compiled in this list. The agreement was signed between defence PSU Goa Shipyard Ltd and Russia's state-run defence major Rosoboronexport under the government-to-government framework for defence cooperation. Two large amphibious assault ships of the improved Project 11711 currently under construction at the Yantar Shipyard on the Baltic coast will displace 40% more tonnes compared to standard warships of this … The Royal Navy had to intercept nine Russian warships as they sailed in waters around the UK over the past two weeks. Their show of sea power comes as Moscow warns America it … The upgraded Project 11711 two large amphibious assault ships Vladimir Andreyev and Vasily Trushin were laid down at the Yantar Shipyard in April 2019. Russian warships arrive in the Philippines amid rising South China Sea tensions. The Russian Navy has dispatched a fourth warship to Syria's Mediterranean coast as tensions over the northwestern province of Idlib spiral with Turkey, amateur ship spotters reported Monday. The two-day naval phase of the AMAN-2021 drill off the coast of Pakistan has finished. Besides China, the United States, Japan and South Korea have warships with a displacement of 10000 tons (from 9300 to 10450) which exceed the projected Russian 22350M in size. 15. India, Russia finalise USD 500 million deal for construction of 2 warships for Indian Navy 20 Nov, 2018, 06.33 PM IST. PBO comes under fire as navy worries about watchdog's report on troubled warship project Premium content David Pugliese, Ottawa Citizen, Postmedia News ( [email protected] ) There are more than 280 warships, submarines and warfare boats believed to be in active service with the Russian Navy, on reserve, or under construction, based on public reports compiled in this list. The Russian Navy's Baltic Fleet said the two vessels successfully accomplished the mission, which included multiple drills. The modular scheme is revolutionary for the Russian Navy. Patrol ship HMS Severn was on duty in the English Channel and Dover Strait, where it shadowed a surfaced Kilo-class submarine, the Stary Oskol, the corvette Boikiy, patrol ship Vasiliy Bykov and support ships. This week a group of Baltic Fleet warships that included the Project 20380 multi-purpose guided missile corvettes Boiky and Steregushchiy returned to their homeport of Baltiysk following a long-distance deployment mission in the North Atlantic. Royal Navy shadows nine Russian warships around the UK By Ben Mitchell, PA. 05/12/2020. Besides China, the United States, Japan and South Korea have warships with a displacement of 10000 tons (from 9300 to 10450) which exceed the projected Russian 22350M in size. Severn was also on patrol as the Vice-Admiral Kulakov sailed through the Channel. Best warships and submarines of Russia's Northern fleet. Russia's Yantar … The decision to sail a fleet of Russian warships through the English Channel could be a "distraction" to divert the world's attention from military operations elsewhere, an … In very challenging conditions with rough weather, Severn and several other British and allied ships, have spent 20 days ensuring that Russian transiting warships remain under our … By Rebecca Perring PUBLISHED: 10:24, Thu, Mar 26, 2020 … He added that the most advanced Russian missile systems S-400 Triumph are currently on combat duty on the Novaya Zemlya archipelago. The warships are used in green water/littoral zone operations, patrol coastal waters, for engagement of enemy surface ships and submarines, and can provide gun support for landing operations. The Steregushchiy is the Project 20380 lead corvette, and she has been operational in the Baltic Fleet since February 2008, while the Boiky is the Project's third warship and was the second serial-produced ship. Russian warships and naval assets sailing through Bosphorus strait has Turkey frightened. The deal permits Russia to keep up to 11 vessels in Tartus, including nuclear-powered submarines and Moscow is investing $500M in infrastructure improvements at the base. 2013. Gorshkov may be a new ship, but it's a poster child for everything wrong with the Russian military. WATCH Russian warships take part in Pakistan-hosted naval AMAN-2021 maneuvers alongside NATO members 17 Feb, 2021 08:17 . In October 2018, India signed a contract to buy two of the under-construction Admiral Grigorovich class ships originally meant for the Russian … Its successful implementation opens a way to Russian warships of the future, the Izvestia said. In 2016, Russia suspended the construction of three ships of the Admiral Grigorovich class, meant for its navy, at the Yantar Shipyard after Ukraine halted delivery of gas turbines to power the ships due to Moscow's invasion of Crimea. Russia's military budget expanded from 1998 until 2015, but economic problems including a sharp decline in oils led to budget cuts in 2016. ... Guide-Missile Corvette / Frigate Warship. In very challenging conditions with rough weather, Severn and several other British and allied ships, have spent 20 days ensuring that Russian transiting warships remain under … Perhaps the most important part of the eleven-week long mission was for the Russian Navy to show that its warships can operate for such lengths far from Russia's littoral waters. NINE RUSSIAN warships have sailed around the UK in the past two weeks, prompting the Royal Navy to warn they were "ready to respond". HMS Monmouth (F235) Guided-Missile Frigate Warship. Two large amphibious assault ships of the improved Project 11711 currently under construction at the Yantar Shipyard on the Baltic coast will displace 40% more tonnes compared to standard warships of this class, … Nine Russian warships near UK escorted by Royal Navy and NATO allies. Together with another Type-055 under construction on the left of the image, this brings the total number of large destroyers visible to 9. 2006. © Copyright 2021 Center for the National Interest All Rights Reserved. Russian warships have been shadowed through the English Channel by the Royal Navy. "In the Atlantic Ocean, the warships' crews held drills for air, anti-ship and anti-submarine warfare (ASW) defense and practiced assigned tasks.". Russia Business Today follows the emerging business trends in Russia pertaining to economics, energy, construction, manufacturing, agriculture and infrastructure. The corvettes were part of Russian president Vladimir Putin's calls for an upgrade to the Russian Navy in 2013. "The basic task of the deployment by the corvettes Boiky and Steregushchiy to the Atlantic was to ensure the constant naval presence of the Baltic Fleet's ships in the area of its responsibility," Martov added. First Sea Lord Admiral Tony Radakin said: 'This is why the Royal Navy is at sea every day, protecting the UK and our interests. In 2016, Russia suspended construction of three ships of the Admiral Grigorovich class, meant for its navy, at the Yantar Shipyard after Ukraine halted delivery of gas turbines to power the ships due to Moscow's invasion of Crimea. The Russian Navy operates five Project 20380 corvettes and another five are under construction. NINE RUSSIAN warships have sailed around the UK in the past two weeks, prompting the Royal Navy to warn they were "ready to respond". In an ideal world, the escort task would be … Buyan-class (Project 21630 / 21631) Corvette Warship. Russian … Delta III (Project 667BDR Kalmar) Nuclear-Powered Ballistic Missile Attack Submarine. By Dylan Donnelly PUBLISHED: 20:18, Tue, Nov 24, 2020 A total of twenty-four have been planned. There is often concern that the RN is fielding vessels out-gunned by their Russian counterparts and in particular, the OPVs are under-armed for the task. The Royal Navy showed its flexibility in being able to shadow the Russian vessels, says a British naval commanding officer. Moscow is currently working to empower its fleets on the world seas and have a total of nine surface vessels with long-distance capacities under construction. Russia and India signed contracts in November 2018 on the delivery of four Project 11356 frigates. 1993. The missiles are to be fitted on the under-construction Vishakhapatnam class warships of ... DRDO under its project PJ 10. A total of twenty-four have been planned. The corvettes utilize a combined bridge and command center. During their deployment that lasted seventy-seven days, the corvettes Boiky and Steregushchiy covered a total distance of almost 9,500 nautical miles," Baltic Fleet spokesman Roman Martov told Tass earlier this week. 1981 . Under closer scrutiny, the trip hardly looks threatening. The strait that separates the Black Sea from the Mediterranean is … The ship has recently been named INS Vikrant and is … HMS Tyne, HMS Richmond and HMS Kent jointly escorted the same group of Russian ships as they operated in the Celtic Sea. Additional training included the corvettes' personnel and anti-terror squads to ensure readiness to defend the ships against saboteurs or another amphibious raiding party. From a strategic perspective, this is about a Russian influence in the Levant. Dmitri Donskoi (TK-208) Ballistic Missile … A second carrier, Indigenous Aircraft Carrier-1 (IAC-1), began construction in 2005. Get short URL . HMS Montrose (F236) Guided-Missile Frigate Warship. The corvettes have an upgraded construction, arms and seaworthiness. HMS Iron Duke (F234) Guided-Missile Frigate Warship. Under the deal, Russia will provide design, technology know how and key materials to GSL for construction of the ships in India. The Russian Navy currently operates six of the Project 20380 multi-purpose guided missile corvettes, while two additional warships of the class are under construction. 7. The warships are used in green water/littoral zone operations, patrol coastal waters, for engagement of enemy surface ships and submarines and can provide gun support for landing operations. Jul 11, 2017 - Explore Richard Faxon's WARZONE's board "Russian Warships", followed by 849 people on Pinterest. HMS Prince of Wales (R09) Conventionally-Powered … Russia's Sevmash Shipyard has developed a new block-modular method to build nuclear submarines that could reduce the construction period by nearly 18 months. Tributes paid to 'cheeky, lovely' boy, 9, who died after being injured at home. Tributes paid to 'cheeky, lovely' boy, 9, who died after being injured at home. The Russian Navy has dispatched a fourth warship to Syria's Mediterranean coast as tensions over the northwestern province of Idlib spiral with Turkey, amateur ship spotters reported Monday. Putin ramps up Russia's military might with 40 new warships in 2020 RUSSIA has ramped up its military might as the Navy is set to receive 40 new warships this year. The Navy ordered ten ships. The event brings together 45 nations, including three with the largest navies, the US, China, and Russia. The payload change technology is implemented on project 20386 corvettes. Russia's navy chief, Adm. Nikolai Yevmenov, said that more than 50 warships and about 40 aircraft were taking part in the exercise in the Bering Sea, which involved multiple practice missile launches. Warships, submarines, logistical vessels and related watercraft currently in service with the Russian Navy. RUSSIA has sparked a Royal Navy alert during the coronavirus pandemic after seven Russian warships were spotted in the Channel and North Sea. Everyday low prices and free delivery on eligible orders. Follow RT on. 1994. The ships have included a surfaced submarine, a destroyer, a corvette and a patrol ship along with their supporting tugs and supply ships travelling in the English Channel, Celtic Sea and the west coast of Scotland. 'Even with the pressures of Covid, we remain at short notice to respond to threats both in home waters and around the world. Get your need-to-know Today, the Russian fleet has more than 200 surface warships. Meanwhile, Northern Fleet commander Alexander Moiseyev has underscored that air defence of the Russian segment of the Arctic is being improved and the Northern Sea Route is under reliable protection. Some Russian sailors may have returned home in time for Christmas. BSF. THE Royal Navy and NATO allies have escorted nine Russian Navy warships during heightened levels of activity in the waters close to the UK. Russian transiting warships remain under our watchful eyes.' More: UK. 4. A contract for the construction of the two Project 23900 warships was signed by the Russian Ministry of Defense in May 2020, valued at around $1.36 billion, with … Last Update: 18, January, 2021 : Russian Navy 2021 : BF - Baltic Fleet, BSF - Black Sea Fleet, NF - Northern Fleet, PF - Pacific Fleet, CF - Caspian Flotilla : Class. Commander Philip Harper, Severn's commanding officer, said: 'In very challenging conditions with rough weather, Severn and several other British and allied ships have spent 20 days ensuring that, Russian transiting warships remain under our watchful eyes.', Tiger Woods undergoing surgery after car crash in Los Angeles, French actor Gerard Depardieu, 72, charged with raping actress in her 20s, Lenient sentences for domestic abuse killings send a dangerous message. For some of the operation, the Russian ships sheltered from bad weather within the Baie de Seine, northern France, where Severn was joined by allied French navy ships and aircraft. Thus, as the Nanchang construction takes five years, the Chinese Navy will have several warships of the type by late 2023. The task group were joined by RAF Typhoon and F-35s jets, plus tankers RFA Tideforce and RFA Tiderace. The Project 20380 corvettes were developed by the Almaz Central Marine Design Bureau in St. Petersburg, and are armed with multi-purpose artillery guns, surface-to-air missile/artillery systems, supersonic missiles, automatic artillery launchers and other types of armament. Get in touch with our news team by emailing us at webnews@metro.co.uk. The Petropavlovsk class, sometimes referred to as the Poltava class, was a class of three pre-dreadnought battleships built for the Imperial Russian Navy during the 1890s. HMS Lancaster joined Severn tracking Steregushchiy-class corvette Boikiy in the Channel and using its Wildcat helicopter to gather intelligence. PF. For more stories like this, check our news page. Russian transiting warships remain under our watchful eyes.' More: UK. The Russian Navy currently operates six of the Project 20380 multi-purpose guided missile corvettes, while two additional warships of the class are under construction. HMS Defender (D36) Air Defense / Guided Missile Destroyer Warship. 1993. 8. India Navy fully pays for frigates under construction at Russian shipyard September 2019 News Navy Naval Maritime Defense Industry Posted On Wednesday, 25 September 2019 11:28 India has fully paid for the Project 11356 missile frigates, which Russia's Yantar Shipyard in the Kaliningrad Region is building for the Indian Navy, President of the United Shipbuilding … The corvette Soobrazitelny was shown to the public for the first time at the Fifth International Maritime Defence Show (IMDS-2011) in St. Petersburg. Warship Proposal. Thus, as the Nanchang construction takes five years, the Chinese Navy will have several warships of the type by late 2023. THE US Navy has sent a warship to the Western Pacific in an effort to challenge Russia's "excessive" maritime claims. Again there are both Type-052D and Type-055 ships. Russia's navy chief, Adm. Nikolai Yevmenov, said that more than 50 warships and about 40 aircraft were taking part in the exercise in the Bering Sea, which involved multiple practice missile launches. On this day in 1696 the Boyar Duma, following the initiative of Peter the Great, passed a decree to begin construction of a regular navy. Case dropped against journalist arrested after taking photos of … Russia Business Today follows the emerging business trends in Russia pertaining to economics, energy, construction, manufacturing, agriculture and infrastructure. Putin ramps up Russia's military might with 40 new warships in 2020 RUSSIA has ramped up its military might as the Navy is set to receive 40 new warships this year. She has been in service since May 2013. latest news, feel-good stories, analysis and more, Prince Philip's illness revealed as Palace warns he'll be in hospital for days, 18 people rescued from back of refrigerated lorry at service station, Blind woman collapses in street as bulldogs maul her guide dog, Police forced to tell doggers illicit meet-ups not 'essential travel', Thousands sign petition to make June 21 a bank holiday. The Project 20380 corvettes also carry a Ka-27 helicopter. By Brian McGleenon. The Royal Navy has monitored nine Russian vessels around the UK in recent weeks. They were transferred to the Pacific Squadron upon completion and based at Port Arthur before the start of the Russo-Japanese War of 1904–1905. Buy Russian Warships in the Age of Sail 1696-1860: Design, Construction, Careers and Fates 1st Edition by John Tredrea, Eduard Sozaev (ISBN: 9781848320581) from Amazon's Book Store. BF. 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russian warships under construction 2021


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Hold the University of Michigan Accountable for new international student fee
Allan Martell signed this petition…
Allan Martell started this petition to Martin A. Philbert - Provost at the University of Michigan
[Click here to read the petition in Mandarin]
On June 20, 2019, the University of Michigan's Board of Regents approved a new fee of $500 per term for international students on F or J visas. However, the University administration has yet to provide a coherent explanation as to why this fee is necessary and where the money will go.
This fee is the first of its kind at the University of Michigan, and represents a stark departure from its commitment to Diversity Equity and Inclusion (DEI). The fee, of $1000-$1500 per student per year, will exacerbate the already substantial financial burden placed on international students, who represent 14.9% of the total student body at U of M.
The University administration has argued that the fee is necessary to "cover the cost of sustaining and enhancing services to support the success of international students and compliance and reporting requirements." However, the University's own FAQ, states that the University has not yet decided how the money will be used. The University administration has provided no evidence that the operational costs of the International Center — the main regulatory interface between students and the university — have increased and has stated that the fee will not be used to fund the International Center. No information has been provided about how the University plans to use the $3-5 million that this fee will raise per year. How these raised funds will indeed go towards supporting international student services remains unclear.
Far from representing an opportunity for improvement of services to international students, this new fee increases a financial burden without a payoff. International students are already vulnerable given their immigration status, especially at a time when immigration policies and the political discourse have put them on the spotlight. If the university wants to act on their stated commitment to international students, adding a financial burden and singling them out from the larger student body is not the way to do so.
In the absence of a budgetary problem to solve and the lack of consultation to international students' in the decision process, the new fee is unjustified. It also sets a dangerous precedent. There is a real possibility that, in the future, the University administration will raise the amount without justification or demonstrated need, or that the university will impose new fees targeting other demographics on campus. Furthermore, there is also no guarantee that the provost's office will continue to pay or waive the fee for PhD students, putting this new financial burden on departments, or on the students themselves, in the future.
Because of the high stakes involved in the imposition of this unjustified fee, we ask provost Martin A. Philbert to hold a town hall as soon as possible to inform students which problems will the fee solve and how the university will use the money.


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Clinical characteristics in a kindred with early-onset alzheimer's disease and their linkage to a g→t change at position 2149 of the amyloid precursor protein gene
Martin Farlow, J. Murrell, Bernardino Ghetti, Frederick Unverzagt, S. Zeldenrust, Merrill Benson
Patients from five generations of a family developed presenile Alzheimer's disease (AD) early in the fifth decade. Recent memory, information-processing speed, sequential tracking, and conceptual reasoning were the earliest cognitive functions affected. Language and visuoperceptual skills were largely spared early in the course of the disease. Later, there were progressive cognitive deficits and inability to perform the activities of daily living. Death occurred, on average, 6 years after onset. Three autopsies in affected members revealed cerebral amyloid deposits and neurofibrillary tangles. Clinical and pathologic features were typical for familial AD. Direct DNA sequencing revealed a G→T change at position 2149 of the amyloid precursor protein (APP) gene that resulted in the substitution of phenylalanine for valine in the transmembrane domain of the mature protein. This mutation was present in DNA from all four examined affected individuals and linked to the disease with a lod score of 3.25, and was the most probable cause of AD in this family.
Amyloid beta-Protein Precursor
Lod Score
Automatic Data Processing
Farlow, M., Murrell, J., Ghetti, B., Unverzagt, F., Zeldenrust, S., & Benson, M. (1994). Clinical characteristics in a kindred with early-onset alzheimer's disease and their linkage to a g→t change at position 2149 of the amyloid precursor protein gene. Neurology, 44(1), 105-111.
Clinical characteristics in a kindred with early-onset alzheimer's disease and their linkage to a g→t change at position 2149 of the amyloid precursor protein gene. / Farlow, Martin; Murrell, J.; Ghetti, Bernardino; Unverzagt, Frederick; Zeldenrust, S.; Benson, Merrill.
In: Neurology, Vol. 44, No. 1, 1994, p. 105-111.
Farlow, M, Murrell, J, Ghetti, B, Unverzagt, F, Zeldenrust, S & Benson, M 1994, 'Clinical characteristics in a kindred with early-onset alzheimer's disease and their linkage to a g→t change at position 2149 of the amyloid precursor protein gene', Neurology, vol. 44, no. 1, pp. 105-111.
Farlow M, Murrell J, Ghetti B, Unverzagt F, Zeldenrust S, Benson M. Clinical characteristics in a kindred with early-onset alzheimer's disease and their linkage to a g→t change at position 2149 of the amyloid precursor protein gene. Neurology. 1994;44(1):105-111.
Farlow, Martin ; Murrell, J. ; Ghetti, Bernardino ; Unverzagt, Frederick ; Zeldenrust, S. ; Benson, Merrill. / Clinical characteristics in a kindred with early-onset alzheimer's disease and their linkage to a g→t change at position 2149 of the amyloid precursor protein gene. In: Neurology. 1994 ; Vol. 44, No. 1. pp. 105-111.
@article{f4618943e4f14492aab12e5a6bd2e678,
title = "Clinical characteristics in a kindred with early-onset alzheimer's disease and their linkage to a g→t change at position 2149 of the amyloid precursor protein gene",
abstract = "Patients from five generations of a family developed presenile Alzheimer's disease (AD) early in the fifth decade. Recent memory, information-processing speed, sequential tracking, and conceptual reasoning were the earliest cognitive functions affected. Language and visuoperceptual skills were largely spared early in the course of the disease. Later, there were progressive cognitive deficits and inability to perform the activities of daily living. Death occurred, on average, 6 years after onset. Three autopsies in affected members revealed cerebral amyloid deposits and neurofibrillary tangles. Clinical and pathologic features were typical for familial AD. Direct DNA sequencing revealed a G→T change at position 2149 of the amyloid precursor protein (APP) gene that resulted in the substitution of phenylalanine for valine in the transmembrane domain of the mature protein. This mutation was present in DNA from all four examined affected individuals and linked to the disease with a lod score of 3.25, and was the most probable cause of AD in this family.",
author = "Martin Farlow and J. Murrell and Bernardino Ghetti and Frederick Unverzagt and S. Zeldenrust and Merrill Benson",
T1 - Clinical characteristics in a kindred with early-onset alzheimer's disease and their linkage to a g→t change at position 2149 of the amyloid precursor protein gene
AU - Farlow, Martin
AU - Murrell, J.
AU - Ghetti, Bernardino
AU - Unverzagt, Frederick
AU - Zeldenrust, S.
AU - Benson, Merrill
N2 - Patients from five generations of a family developed presenile Alzheimer's disease (AD) early in the fifth decade. Recent memory, information-processing speed, sequential tracking, and conceptual reasoning were the earliest cognitive functions affected. Language and visuoperceptual skills were largely spared early in the course of the disease. Later, there were progressive cognitive deficits and inability to perform the activities of daily living. Death occurred, on average, 6 years after onset. Three autopsies in affected members revealed cerebral amyloid deposits and neurofibrillary tangles. Clinical and pathologic features were typical for familial AD. Direct DNA sequencing revealed a G→T change at position 2149 of the amyloid precursor protein (APP) gene that resulted in the substitution of phenylalanine for valine in the transmembrane domain of the mature protein. This mutation was present in DNA from all four examined affected individuals and linked to the disease with a lod score of 3.25, and was the most probable cause of AD in this family.
AB - Patients from five generations of a family developed presenile Alzheimer's disease (AD) early in the fifth decade. Recent memory, information-processing speed, sequential tracking, and conceptual reasoning were the earliest cognitive functions affected. Language and visuoperceptual skills were largely spared early in the course of the disease. Later, there were progressive cognitive deficits and inability to perform the activities of daily living. Death occurred, on average, 6 years after onset. Three autopsies in affected members revealed cerebral amyloid deposits and neurofibrillary tangles. Clinical and pathologic features were typical for familial AD. Direct DNA sequencing revealed a G→T change at position 2149 of the amyloid precursor protein (APP) gene that resulted in the substitution of phenylalanine for valine in the transmembrane domain of the mature protein. This mutation was present in DNA from all four examined affected individuals and linked to the disease with a lod score of 3.25, and was the most probable cause of AD in this family.


The prolific and successful Brothers Pearse Camogie Club was formed in 1991, after Noreen Heston approached Brothers Pearse Hurling & Football Club with a view to setting up a camogie club. Together with Gerry Rea, Bill Riley, and Kevin Murphy, Noreen arranged a meeting in the Duke of Clarence, and Brothers Pearse Camogie Club was born.
The club made it's debut against Tara at the Richmond Irish Festival against Tara and marked the start of one of the most successful camogie clubs in London. As the existing Brothers Pearse club colours of green and white were already in use by another camogie club in London, the camogie club opted for the green and red of founder Noreen Heston's home county, Mayo. Bill Riley sponsored their first set of jerseys and, with Gerry Rea as team manager, the club commenced training in Aylestone Avenue, Willesden, where they rented their own pitch.
Click on a time period below to read more about our history.
Within the first year of being formed, the club had already made its mark on the London camogie scene by securing both the London Junior and England Provincial Camogie Championships. This marked the beginning of an upward spiral, including winning the London Senior Championship and League double for five consecutive years from 1998 – 2002.
In 1993, and in light of its success, the club was upgraded from junior to intermediate fgrade. The new challenge did not face the players who – far from just holding their own – managed to win the Intermediate Championship at their first attempt.
Upgrading again took place in 1994 having won the intermediate title in 1993. Brothers Pearse joined the senior ranks and participated from 1994 to 1997 without success at senior level. However in 1995 Brothers Pearse did defeat Erin Go Bragh in the senior reserve championship. Brothers Pearse reign in London camogie started in 1998.
In 1996 the camogie club established it's own individual committee and embarked on a recruitment drive for new players and members. In 1997 the club were in the fortuitous position of entering both senior and junior teams in the London camogie board competitions.
In 1998 Brothers Pearse camogie club progressed further and entered senior, intermediate and junior teams to take part in London domestic competitions. This was the first and only time in London camogie's history that a club entered teams at all three levels. Paddy Carr, Galway took charge of the training, management and selection of all three teams. A position he would hold within the club until his sudden death in December 2006.
Brothers Pearse senior team won both league and championship in 1998 for the first time in its history. This was a huge achievement for the club and something they had been chasing since reaching senior ranks in 1994. Following the senior championship final Brothers Pearse travelled to Liatroim Fontenoys, Co. Down to take part in the All-Ireland club championship quarter final. However with Laitroim Fontenoys in their fourth assault on All-Ireland club victory this was not to be Brothers Pearse's year.
In 1998 the Irish World presented an award to the most outstanding camogie player in London (alongside football and hurling awards). Frances Killeen was the first player in London to be presented this prestigious award for her efforts at full back for the Pearses ladies.
1999 was Brothers Pearse camogie club's most successful year to date. In 1999 the club achieved the ultimate goal – winning both junior and senior league and championship titles. Following this success the senior squad represented London in the All-Ireland club championship quarter final but failed to overthrow Davitts of Galway. A memorable weekend was had by the club, however it did become apparent there was a huge gap between the level of senior clubs playing in London and those competing in senior competitions in Ireland.
In 2000 the club achieved three in a row success with the senior team defeating Tara camogie club in the senior championship final. In the junior championship Brothers Pearse defeated Fr. Murphy's in the championship final. In the All-Ireland club championship Brothers Pearse played host to a youthful Rathnure team and once again faced defeat by their visitors from home.
Roisin O'Neill and Therese Doyle were awarded the Irish World Camogie Player of the Year in 1999 and 2000 respectively.
In October 2001 Brothers Pearse celebrated its 10th Anniversary and the occasion was marked by the club hosting a tournament at Tir Chonnaill Park, Greenford. A total of eight teams travelled from near and far to participate. The day was a great success with Tipperary's Toomevara winning on the day at senior level and John Mitchell's Birmingham proving victorious at junior level. A social event was also organised to ensure the celebrations continued late into the night.
The club participated in the House of Wentworth Festival of Hurling and Shinty Exhibition at Stamford Bridge in May 2001. A memorable day for those involved which will go down in the history books of London gaelic games.
Later in the season the senior team narrowly defeated Erin Go Bragh, by 4 points in the championship final and also topped the league to cap off what was a wonderful year for the club.
In 2002 the club once again secured senior league and championship titles defeating Erin Go Bragh and Croydon in the respective competitions. Lisa Woods received the Irish World Player of the year for 2002.
For many in the club the championship of 2003 will be remembered as the ash clashed harder than ever before in Ruislip as the senior camogie championship final reached fever pitch proportions. Although Brothers Pearse were defeated by arch rivals Croydon a thrilling display of skill and commitment was shown by the Brothers Pearse ladies and the game was in itself a tribute to how much London camogie has evolved since it's early days. However later in the year the Pearses ladies got their revenge on Croydon defeating them in the league final and thus sharing the senior silverware with another club for the first time in six years.
In 2004 the Pearses aim was to retain the championship title which they had given up to Croydon in 2003, bringing to an end the dream of six in a row – something no other London club had achieved. Pearses also proceeded to the league final in 2004 however once again it was a battle with Croydon which ended the dream of doing the double once more at senior level. Croydon won the league in 2004 sharing the silverware with Pearses. Pearses played Castletara of Cavan in the Ulster club championship. Pearses were defeated at the Emerald Grounds Ruislip although came within 5 points of the Cavan champions. Roisín O' Neill was awarded the Irish World Player of the Year for 2004.
2005 was the year for the Pearses junior team. Having been without silverware since their championship win in 2000 the junior players were determined to do well. They trained throughout the year with unquestionable commitment and in October were rewarded by defeating Green Isle, favourites for the title, in a thrilling final which went to extra time. For the senior squad 2005 was one of the most disappointing years loosing to Croydon in the semi-final of the championship. This was the first time in eight years that Pearses were not to feature in the senior final. However, the senior team did gather themselves later in the season to retain the league title and dull the sting from loosing the championship.
In 2005 Bronwyn Keeshan received the Irish World Player of the Year award.
2006 has seen Pearses get themselves back to the top of London camogie winning both senior championship and league. The senior team remained undefeated throughout the season in London and eventually went down to a young Gaultier side from Waterford in the Munster Junior Club Championship by the narrow margin of 7 points. Our junior team competed in both championship and league, however having lost a number of long serving players struggled throughout the season.
Once again Pearses players were recognised at the annual All-Star event held in the Crown Moran Hotel, Cricklewood – Emma Linnane (goal keeper), Therese Doyle (right corner back), Roisin O'Neill (centre back), Bronwyn Keeshan (centre field), Sinead McMahon (centre forward), Patricia Nihill (left half forward) and Suzanne Deasy (full forward).
In 2011, the club went on to win the Junior Championship again and in the same year celebrated its 20th anniversary. On 5th November 2011 past players competed against current players in an exhibition game, the winners being awarded with the Paddy Carr Memorial Cup. A fantastic weekend was had as past players travelled from near and far to attend the game and the dinner dance which followed that night.
In 2012, as many long standing players went in to retirement and some leaving London altogether, the club was then regarded to junior status. And, it has since undergone somewhat of a revival with a new generation of players joining the ranks. These players took Brothers Pearse to the Junior Championship final in 2013, unfortunately losing out to a strong Green Isle side on the day.
In 2014, Brothers Pearse past camogie player, Roisin O'Neill was bestowed with the wonderful honour of being named 'London Camogie Player of the Decade' and she was invited to Croke Park on Camogie All-Ireland Final day, where she was presented with her award.
Roisin was a dedicated player at both club and county level during her time in London. Roisin won Brothers Pearse Senior Player of the year in 2005,2006 and 2007. She also won Brother Pearse club person of the year in 2005, 2006 and 2007. She played as part of the Brothers Pearse Senior Team that won the Senior championship in 1999, 2000, 2001, 2002 and 2004. She was also played as part of the Brothers Pearse team that won the Senior League in 1999, 2000, 2001, 2002, 2003 and 2005. She also captained the Brothers Pearse Team that won the Senior Championship and Senior League in 2006.
Roisin was a driving force behind London's fundraising to enable London to compete at Inter County League and Championship level in Ireland. Without her efforts London may not have been given the opportunity to play at inter county level. She was also nominated as the Camogie Ambassador for London during the Centenary celebrations.
Roisin was a consistent and dedicated member of both Club & County Boards. She was PRO for the County Board and Chairperson of the County Board. During her time as Brothers Pearse she was Secretary, chairperson and PRO for our club. She was a referee between 2005 and 2008. She also Promoted and developed Underage Camogie in London 2005.
This is a fantastic achievement and is more than well deserved. We would like to take this opportunity to congratulate Roisin on this amazing achievement.
Since it's formation in 1991 Brothers Pearse camogie club have travelled far and wide to play camogie and to promote the club. The club has travelled to Boston, USA in 2000, Tir Chonaill Harps, Glasgow, Scotland in 2004 and to various clubs throughout Ireland including Duffey Rovers (Co Wexford) Liatroim Fontenoys (Co. Down), Davitts (Co. Galway) and Gaultier (Co. Waterford). The club have also hosted Burgess (Co. Tipperary), Rathnure (Co. Wexford), St. Brigids (Co. Armagh) and Toomevara (Co. Tipperary). The club's willingness to travel and host visitors to London helps promote integration between Irish and British clubs along with raising the level of awareness of camogie in Britain. Further trips are planned in the near future.


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Smith L.M, Sanders JZ, Kaiser RJ, Hughes P, Dodd C, Connell CR, Heiner C, Kent SBH, Hood LE. 1986. Fluorescence detection in automated DNA sequence analysis. Nature. 321:674-9.
Smith L.M, Fung S, Hunkapiller MW, Hunkapiller TJ, Hood LE. 1985. The synthesis of oligonucleotides containing an aliphatic amino group at the 5' terminus: synthesis of fluorescent DNA primers for use in DNA sequence analysis. Nucleic Acids Research. 13:2399-412.
Mehdi S.Q, Recktenwald D.J, Smith L.M, Li G.C, Armour E.P, Hahn G.M. 1984. Effect of hyperthermia on murine cell surface histocompatibility antigens. Cancer Research. 44:3394-3397.
Smith L.M, Petty H.R, Parham P., McConnell H.M. 1982. Cell surface properties of HLA antigens on Epstein-Barr virus-transformed cell lines. Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences. 79:608-612.
Cartwright GS, Smith L.M, Heinzelmann EW, Ruebush MJ, J. Parce W, McConnell HM. 1982. H-2Kk and vesicular stomatitis virus G proteins are not extensively associated in reconstituted membranes recognized by T cells. Proceedings of the National Academy of Sciences of the United States of America. 79:1506-10.
Howard F.D, Ledbetter J.A, Carter D.P, Smith L.M, McConnell H.M. 1982. The lateral mobility and surface distribution of Lyt-1, Lyt-2 and Lyt-3 on mouse thymocytes. Molecular Immunology. 19:1481-1489.
Hafeman D.G, Smith L.M, Fearon D.T, McConnell H.M. 1982. Lipid monolayer-coated solid surfaces do not perturb the lateral motion and distribution of C3b receptors on neutrophils. Journal of Cell Biology. 94:224-227.
Smith L.M. 1981. The Lateral and Rotational Motion of Membrane Components. 8115832:168p..
Smith L.M, Weis RM, McConnell HM. 1981. Measurement of rotational motion in membranes using fluorescence recovery after photobleaching. Biophysical Journal. 36:73-91.
Smith L.M, McConnell H.M, Smith B.A, Parce J.W. 1981. Pattern photobleaching of fluorescent lipid vesicles using polarized laser light. Biophysical Journal. 33:139-146.
Smith L.M, Rubenstein JLR, J. Parce W, McConnell HM. 1980. Lateral diffusion of M-13 coat protein in mixtures of phosphatidylcholine and cholesterol. Biochemistry. 19:5907-11.
Petty HR, Smith L.M, Fearon DT, McConnell HM. 1980. Lateral distribution and diffusion of the C3b receptor of complement, HLA antigens, and lipid probes in peripheral blood leukocytes. Proceedings of the National Academy of Sciences of the United States of America. 77:6587-91.
Smith L.M, J. Parce W, Smith BA, McConnell HM. 1979. Antibodies bound to lipid haptens in model membranes diffuse as rapidly as the lipids themselves. Proceedings of the National Academy of Sciences of the United States of America. 76:4177-9.
Smith L.M, Smith BA, McConnell HM. 1979. Lateral diffusion of M-13 coat protein in model membranes. Biochemistry. 18:2256-9.


The internet is vomiting new strategies to creating wealth every day. From monetizing blogs to online tutoring, you can make sets from some amount of money to hundreds of dollars on a regular basis. The somewhat recent phenomenon on the web is UGC or User Generated Content. In brief this is content supplied by the consumer and it may be in audio or video formats. Sites like YouTube and Google video have provides a platform to huge numbers of people across the world that are aspiring actors, musicians, directors, chefs or even magicians to shoot their particular videos and post it on the internet. Your situation has even arrive at a place where you can actually make money using YouTube videos.
There are plenty of videos watched each day all across the globe which means you can engage in we now have and commence making money with your Youtube videos. You can make extra cash in the home by making a website in your account and registering with YouTube videos. Depending upon the videos, thousands of visitors will login to your watch the videos along with the advertisements furnished by Google. With your videos, you can add short descriptions with the video along with the links.
So how do you work from home opportunities videos? Let us commence with a straightforward instance of that the business would make money with YouTube videos. Allow us to repeat the clients are active in the manufacturing of ready-to-eat packaged food and is of a former chef. You will find there's type of internet marketing called viral marketing which can be this is the passing of a message/advertising to a couple individuals who in turn will give it to a lot of people they do know which will result in thousands of people receiving and viewing the advertisement.
It is possible to refer to it as the internet's word-of-mouth kind of promotion. Now returning to the example, the chef so that you can popularize his products may start shooting cooking videos of varied recipes and posting them on the internet. After that you can mail people who would be thinking about this once an interest in it is generated, the cook is popular right away. If the video gets greater than a 1000 hits (or views) that automatically beats about 90% of all the videos on-line. The recognition will ultimately lead to an increase in the sales with the product.
These can be a typical demonstration of a company today experiencing the world wide web platform trying to boost its sales and make cash with YouTube videos being a advertising tool. What about somebody wanting to do the same without really creating a business? Men and women will have to keep working harder initially to go to a place which you could can even make money using YouTube videos. The concept is always to regularly post good videos (that could be informative or entertaining or both) on topics that you just are a professional in. Keep making videos and uploading them regularly onto YouTube.


The Monroe upholstery series has an Edwardian-inspired shape with French Moderne details including the wooden ash banding around the base and gracefully tapered solid ash legs. It has a 4-way hand-tied tight back for lumbar support and luxurious comfort. Light Walnut is the standard finish. The series includes an 84-inch sofa with two seat cushions and three front posts and a 96-inch sofa with three seat cushions and four front posts, a chair, and an ottoman. The Monroe series is standard with welt trim. Two 22-inch 100% goose feather throw pillows standard in fabric. 2-piece Luxury Spring-Down seat cushion standard. Optional NP-08 nail head trim around base shown. Optional Parchment paint shown.


text:
President Joe Biden signs executive orders on stimulus checks, food stamps and minimum wage
todayApril 4, 2020	142	3
President Joe Biden signs executive orders on stimulus checks, food stamps and minimum wage radiointernational
You can click on the media above to play President speech about the stimulus executive order
Washington — President Joe Biden signed two executive orders on Friday, one of which would increase federal food assistance and streamline the delivery of stimulus checks, as the president attempts to stabilize the economy without congressional assistance amid the fallout from the coronavirus pandemic.
"We have to act now," Mr. Biden said in remarks before he signed the orders. "We cannot, will not, let people go hungry."
Mr. Biden has proposed a $1.9 trillion relief plan to Congress, but it is unclear whether it will garner enough Republican support to pass on a bipartisan basis. Until Congress is able to pass another relief bill, Mr. Biden's actions are intended as stopgap measures to stabilize the economy.
Some Republicans have questioned whether there is still a need for a second, larger relief bill after Congress passed a $900 billion bill in December. But in his remarks on Friday, Mr. Biden said that the most recent relief bill was just a "downpayment."
"We need more action, and we need to move fast," Mr. Biden said. "We're in a national emergency. We need to act like we're in a national emergency. So we've got to move with everything we've got."
In the first order, Mr. Biden asks the U.S. Department of Agriculture to allow states to increase Supplemental Nutrition Assistance Program (SNAP) benefits — commonly known as food stamps — by 15%. Congress recently passed a $1 trillion relief bill that boosted the maximum SNAP benefit by 15%, but that did not help the 40% of SNAP recipients who were already at the maximum benefit. Mr. Biden's order tells the USDA to "consider issuing new guidance that would allow states to increase SNAP emergency allotments for those who need it most," according to a fact sheet provided by the White House, which would mean that an additional 12 million people get enhanced benefits.
The order would also increase Pandemic-EBT, an electronic debit card program for students who would have qualified for free or reduced-price meals at school. Mr. Biden is directing the USDA to "consider issuing new guidance increasing P-EBT benefits by approximately 15% to accurately reflect the costs of missing meals and make it easier for households to claim benefits." According to the White House, this could provide a family with three children an additional $100 in support per month.
Source and Credit: CBS NEWS
Written by: radiointernational
Authors Cool music Dj Music Club Music themes
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L'ex-sénateur Nènel Cassy arrêté puis libéré
L'ex-sénateur Nènel Cassy arrêté puis libéré L'ex-sénateur Nènel Cassy et une dizaine de « militants politiques » arrêtés en marge d'une manifestation antigouvernementale à Mirago leur arrestation en marge d'une manifestation antigouvernementale à Miragoâne, le jeudi 21 janvier, ont été libérés dans la soirée. Selon le Commissaire du Gouvernement, l'ancien Sénateur du parti Fanmi Lavalas était accompagné de quatre policiers portant des armes illégales dont des fusils d'assaut. Par ailleurs, […]
todayApril 3, 2020	22 3
todayApril 4, 2020	50 4 4
todayApril 4, 2020	142 3 3


text:
package jp.tf_web.radiolink.ncmb.gcm;

import com.nifty.cloud.mb.core.NCMBException;

import jp.tf_web.radiolink.ncmb.db.User;

/**
 * Created by furukawanobuyuki on 2016/01/14.
 */
public interface GcmUtilRegistrationListener {
    /** 成功
     *
     */
    void success(final User user);

    /** 失敗
     *
     * @param saveErr
     */
    void error(NCMBException saveErr);
}

redpajama_set_name: RedPajamaGithub


text:
package io.github.winsontse.hearteyes.app;

import android.content.Context;
import android.content.SharedPreferences;
import android.content.res.Resources;

import dagger.Component;
import io.github.winsontse.hearteyes.model.local.IAccountManager;
import io.github.winsontse.hearteyes.model.remote.CircleService;
import io.github.winsontse.hearteyes.model.remote.UserService;
import io.github.winsontse.hearteyes.model.remote.WeiboService;
import io.github.winsontse.hearteyes.util.scope.ApplicationScope;

/**
 * Created by hao.xie on 16/5/9.
 */

@ApplicationScope
@Component(modules = {AppModule.class})
public interface AppComponent {

    Context getApplicationContext();

    WeiboService getWeiboService();

    UserService getUserService();

    CircleService getCircleService();

    LeanCloudManager getLeanCloudManager();

    Resources getResources();

    SharedPreferences getSharedPreferences();

    IAccountManager getAccountManager();
}