text:
Omics score: 26
ApoD modulation mouse cerebellar transcriptome
ABSTRACT: The lipocalin Apolipoprotein D (ApoD), known to protect the nervous system against oxidative stress (OS) in model organisms, is up-regulated early in the mouse brain in response to the ROS generator paraquat (PQ). However, the processes triggered by this up-regulation have not been explored. Overall design: We present here a study of the effect of ApoD on the early transcriptional changes upon OS in the mouse cerebellum using microarray profiling. ApoD-KO and transgenic mice over-expressing ApoD in neurons are compared to wild-type controls.
INSTRUMENT(S): [Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array
SUBMITTER: Gabriel Gutierrez
PROVIDER: GSE28643 | GEO | 2011-04-16
SECONDARY ACCESSION(S): PRJNA138953
REPOSITORIES: GEO
Project description:The lipocalin Apolipoprotein D (ApoD), known to protect the nervous system against oxidative stress (OS) in model organisms, is up-regulated early in the mouse brain in response to the ROS generator paraquat (PQ). However, the processes triggered by this up-regulation have not been explored. We present here a study of the effect of ApoD on the early transcriptional changes upon OS in the mouse cerebellum using microarray profiling. ApoD-KO and transgenic mice over-expressing ApoD in neurons are compared to wild-type controls.
Coordination of frontline defense mechanisms under severe oxidative stress.
Project description:Oxidative stress (OS) results from genetic defects or stressful environmental challenges that cause unchecked production of reactive oxygen species (ROS). OS has been implicated in many diseases due to its wide ranging damage to nucleic acids, proteins and lipids. Using Halobacterium salinarum NRC-1, an extremophile that thrives under conditions of excessive OS, we have constructed a systems model for oxidative stress response (OSR) by integrating transcriptional changes induced by treatments with H2O2 and paraquat, functional associations inferred through comparative genomics, and de novo discovered cis-regulatory motifs. Together with phenotypic analysis of mutant strains this has revealed a multi-tiered OS management program to transcriptionally coordinate three peroxidase/catalase enzymes, two superoxide dismutases, production of rhodopsins, carotenoids, and gas vesicles, metal trafficking, and various other aspects of metabolism. Remarkably, a significant fraction of this OSR was accurately recapitulated by a model that was previously constructed from cellular responses to diverse environmental perturbations –this constitutes the general stress response component. Notwithstanding this observation, comparison of the two models has identified the coordination of frontline defense and repair systems by regulatory mechanisms that are triggered uniquely by severe OS and not by other environmental stressors, including sub-inhibitory levels of redox-active metals, extreme changes in oxygen tension, and a sub-lethal dose of g rays. Overall design: Mid-log phase cultures of H. salinarum NRC-1 (2 biological replicates) grown in flasks were treated with either sub-lethal concentrations of 25mM H2O2 or 4mM PQ and incubated with shaking for up to 240 min. For each treatment, two time courses were run to determine the transcriptional responses to (1) constant stress and (2) recovery of H. salinarum NRC-1 to H2O2 and PQ. During constant stress, culture aliquots (~4ml) were collected over a time course (-1, 5, 10, 20, 40, 80 and 160 minutes), centrifuged (16000g, 90 seconds) and flash frozen. For recovery, cells were first treated for 2-hours with either 25 mM H2O2 or 4mM PQ, recovered by centrifugation, washed and re-suspended in CM. Cultures were returned to the incubator with shaking and samples were taken at 0, 10, 20, 30, 40, 50, 60, 120, and 240 minutes and processed as described previously. Analysis of temporal transcriptional changes (-1, 0, 5, 10, 20, 40, 80, 160 and 320m) to sub-inhibitory concentrations of PQ (0.25mM) was also characterized. Total RNA was prepared and labeled with Alexa547 and Alexa647 dyes. Intensities were normalized between the Alexa 546 and Alexa 647 channels by scaling all intensities in one channel such that the 75th percentile in each channel was made equal.
Expression data from mouse brain
Project description:A detailed knowledge of the mechanisms underlying brain aging is fundamental to understand its functional decline and the baseline upon which brain pathologies superimpose. Endogenous protective mechanisms must contribute to the adaptability and plasticity still present in the healthy aged brain. Apolipoprotein D (ApoD) is one of the few genes with a consistent and evolutionarily conserved up-regulation in the aged brain. ApoD protecting roles upon stress or injury are well known, but a study of the effects of ApoD expression in the normal aging process is still missing. Using an ApoD-knockout mouse we analyze the effects of ApoD on factors contributing to the functional maintenance of the aged brain. We focused our cellular and molecular analyses in cortex and hippocampus at an age representing the onset of senescence where mortality risks are below 25%, avoiding bias towards long-lived animals. Lack of ApoD causes a prematurely aged brain without altering lifespan. Age-dependent hyperkinesia and memory deficits are accompanied by differential molecular effects in cortex and hippocampus. Transcriptome analyses reveal distinct effects of ApoD loss on the molecular age-dependent patterns of cortex and hippocampus, with different cell-type contributions to age-regulated gene expression. Markers of glial reactivity, proteostasis, and oxidative and inflammatory damage reveal early signs of aging and enhanced brain deterioration in the ApoD-knockout brain. The lack of ApoD results in an age-enhanced significant reduction in neuronal calcium-dependent functionality markers and signs of early reduction of neuronal numbers in the cortex, thus impinging upon parameters clearly differentiating neurodegenerative conditions from healthy brain aging. Our data support the hypothesis that the physiological increased brain expression of ApoD represents a homeostatic anti-aging mechanism. Overall design: The brain cortex and hippocampus of young and aged mice of wild-type and ApoD-KO genotypes were used for RNA extraction and hybridization on Affymetrix microarrays. We aim at identifying distinct effects of ApoD loss on the molecular age-dependent patterns of cortex and hippocampus.
| GSE68169 | GEO
Project description:A detailed knowledge of the mechanisms underlying brain aging is fundamental to understand its functional decline and the baseline upon which brain pathologies superimpose. Endogenous protective mechanisms must contribute to the adaptability and plasticity still present in the healthy aged brain. Apolipoprotein D (ApoD) is one of the few genes with a consistent and evolutionarily conserved up-regulation in the aged brain. ApoD protecting roles upon stress or injury are well known, but a study of the effects of ApoD expression in the normal aging process is still missing. Using an ApoD-knockout mouse we analyze the effects of ApoD on factors contributing to the functional maintenance of the aged brain. We focused our cellular and molecular analyses in cortex and hippocampus at an age representing the onset of senescence where mortality risks are below 25%, avoiding bias towards long-lived animals. Lack of ApoD causes a prematurely aged brain without altering lifespan. Age-dependent hyperkinesia and memory deficits are accompanied by differential molecular effects in cortex and hippocampus. Transcriptome analyses reveal distinct effects of ApoD loss on the molecular age-dependent patterns of cortex and hippocampus, with different cell-type contributions to age-regulated gene expression. Markers of glial reactivity, proteostasis, and oxidative and inflammatory damage reveal early signs of aging and enhanced brain deterioration in the ApoD-knockout brain. The lack of ApoD results in an age-enhanced significant reduction in neuronal calcium-dependent functionality markers and signs of early reduction of neuronal numbers in the cortex, thus impinging upon parameters clearly differentiating neurodegenerative conditions from healthy brain aging. Our data support the hypothesis that the physiological increased brain expression of ApoD represents a homeostatic anti-aging mechanism. The brain cortex and hippocampus of young and aged mice of wild-type and ApoD-KO genotypes were used for RNA extraction and hybridization on Affymetrix microarrays. We aim at identifying distinct effects of ApoD loss on the molecular age-dependent patterns of cortex and hippocampus.
Project description:Oxidative stress (OS) results from genetic defects or stressful environmental challenges that cause unchecked production of reactive oxygen species (ROS). OS has been implicated in many diseases due to its wide ranging damage to nucleic acids, proteins and lipids. Using Halobacterium salinarum NRC-1, an extremophile that thrives under conditions of excessive OS, we have constructed a systems model for oxidative stress response (OSR) by integrating transcriptional changes induced by treatments with H2O2 and paraquat, functional associations inferred through comparative genomics, and de novo discovered cis-regulatory motifs. Together with phenotypic analysis of mutant strains this has revealed a multi-tiered OS management program to transcriptionally coordinate three peroxidase/catalase enzymes, two superoxide dismutases, production of rhodopsins, carotenoids, and gas vesicles, metal trafficking, and various other aspects of metabolism. Remarkably, a significant fraction of this OSR was accurately recapitulated by a model that was previously constructed from cellular responses to diverse environmental perturbations –this constitutes the general stress response component. Notwithstanding this observation, comparison of the two models has identified the coordination of frontline defense and repair systems by regulatory mechanisms that are triggered uniquely by severe OS and not by other environmental stressors, including sub-inhibitory levels of redox-active metals, extreme changes in oxygen tension, and a sub-lethal dose of g rays. Mid-log phase cultures of H. salinarum NRC-1 (2 biological replicates) grown in flasks were treated with either sub-lethal concentrations of 25mM H2O2 or 4mM PQ and incubated with shaking for up to 240 min. For each treatment, two time courses were run to determine the transcriptional responses to (1) constant stress and (2) recovery of H. salinarum NRC-1 to H2O2 and PQ. During constant stress, culture aliquots (~4ml) were collected over a time course (-1, 5, 10, 20, 40, 80 and 160 minutes), centrifuged (16000g, 90 seconds) and flash frozen. For recovery, cells were first treated for 2-hours with either 25 mM H2O2 or 4mM PQ, recovered by centrifugation, washed and re-suspended in CM. Cultures were returned to the incubator with shaking and samples were taken at 0, 10, 20, 30, 40, 50, 60, 120, and 240 minutes and processed as described previously. Analysis of temporal transcriptional changes (-1, 0, 5, 10, 20, 40, 80, 160 and 320m) to sub-inhibitory concentrations of PQ (0.25mM) was also characterized. Total RNA was prepared and labeled with Alexa547 and Alexa647 dyes. Intensities were normalized between the Alexa 546 and Alexa 647 channels by scaling all intensities in one channel such that the 75th percentile in each channel was made equal.
Mining the genome of Arabidopsis thaliana as a basis for the identification of novel bioactive peptides involved in oxidative stress tolerance
Project description:Although evidence accumulates on the role of plant peptides in the response to external conditions, the number of peptide-encoding genes in the genome is still underestimated. In order to identify novel oxidative stress-induced peptides in Arabidopsis thaliana a tiling array analysis (GeneChip® Arabidopsis Tiling 1.0R Arrays ) was performed on mRNA extracted from leaves treated with paraquat (PQ), an reactive oxygen species inducer and water (control), resulting in the identification of 92,844 and 86,272 transcriptionally active regions (TARs), respectively. Normalized log signals were obtained using the Affymetrix Tiling Analysis Software - Version 1.1, Build 2. ON and OFF probes were selected using a treshold, based on positive controls. Next, groups of 4-13 successive ON probes were combined into short TARs and a selection was made of TARs having an average signal intensity at least 2.6-fold higher after PQ treatment compared to the control treatment, resulting in 176 TARS induced by PQ. Overall design: paraquat treated A. thaliana leaves (2 replicates) vs control (water) treated A. thaliana leaves (2 replicates), (4 samples in total)
Evolution of Context Dependent Regulation by Expansion of Feast/Famine Regulatory Proteins
Project description:We validated context dependent regulation by two FFRPs AsnC and VNG1237C by deleting the FFRP and testing the effect on downstream target genes. For validtion of AsnC condition specific regulation we grew wild-type and delta-AsnC in the presence of 4mM paraquat (PQ) and samples at 1 and 160 minutes post addition of this sub-lethal dose of PQ. For validation of VNG1237C we grew wild-type and delta-VNG1237C in a standard growth curve sampling at OD 0.18 and 1.15. The asnC deletion strain (∆asnC) and the control ∆ura3 strain were grown in 4mM paraquat (PQ) and were sampled at 1 and 160 minutes after PQ addition. Sampling timing for ∆VNG1237C was designed such that the starting ODs were as similar as possible and once an OD of 1.17 was reached for ∆ura3 the ∆VNG1237C was sampled at this same time point.
Project description:Although evidence accumulates on the role of plant peptides in the response to external conditions, the number of peptide-encoding genes in the genome is still underestimated. In order to identify novel oxidative stress-induced peptides in Arabidopsis thaliana a tiling array analysis (GeneChip® Arabidopsis Tiling 1.0R Arrays ) was performed on mRNA extracted from leaves treated with paraquat (PQ), an reactive oxygen species inducer and water (control), resulting in the identification of 92,844 and 86,272 transcriptionally active regions (TARs), respectively. Normalized log signals were obtained using the Affymetrix Tiling Analysis Software - Version 1.1, Build 2. ON and OFF probes were selected using a treshold, based on positive controls. Next, groups of 4-13 successive ON probes were combined into short TARs and a selection was made of TARs having an average signal intensity at least 2.6-fold higher after PQ treatment compared to the control treatment, resulting in 176 TARS induced by PQ. paraquat treated A. thaliana leaves (2 replicates) vs control (water) treated A. thaliana leaves (2 replicates), (4 samples in total)
Transcription profiling of E.coli MG1655 and a strain with a precise deletion in soxR treated with paraquat - time series
Project description:SoxR and SoxS constitute an intracellular signal response system that rapidly detects changes in superoxide levels and modulates gene expression in E. coli. A time series microarray design was used to identify co-regulated SoxRS dependent and independent genes affected by superoxide Experiment Overall Design: To determine the immediate transcriptional response of E. coli to superoxide, we conducted a time series assay of mRNA levels immediately following the addition of paraquat. The wild type strain MG1655 and a strain with a precise deletion in soxR was grown in EZ Rich Defined Medium, a modification of Neidhardt's defined rich medium. When cultures reached an OD600=0.5, 250µM paraquat (PQ) was added, a concentration that triggers the SoxRS transcriptional cascade, but only has a small effect on exponential growth rate in rich media. Samples were taken immediately before exposure to PQ, and every 2 minutes after exposure, for 10 minutes.
2008-06-15 | E-GEOD-6992 | ArrayExpress
Autophagy deficient keratinocytes under paraquat stress
Project description:Autophagy is a mechanism that regulates cellular metabolism and clearance of damaged macromolecules and organelles. Impaired degradation of modified macromolecules contributes to cellular dysfunction and is observed in aged tissue and senescent cells. We have inactivated Atg7, an essential autophagy gene, in murine keratinocytes and have found in an earlier study that this resulted in increased baseline oxidative stress and reduced capacity to degrade crosslinked proteins after oxidative ultraviolet stress. To investigate whether autophagy deficiency would promote cellular aging, we studied, how Atg7 deficient (KO) and Atg7 bearing cells (WT) would respond to stress induced by Paraquat (PQ), an oxidant drug commonly used to induce cellular senescence. Overall design: This study was performed in biological triplicates for autophagy competent and deficient mouse Keratinocytes treated with 20µM Paraquat for 48h or sham treated


text:
package pl.grzeslowski.jsupla.protocol.impl.encoders.ds;

import pl.grzeslowski.jsupla.protocol.api.encoders.PrimitiveEncoder;
import pl.grzeslowski.jsupla.protocol.api.encoders.ds.SuplaDeviceChannelBEncoder;
import pl.grzeslowski.jsupla.protocol.api.encoders.ds.SuplaRegisterDeviceCEncoder;
import pl.grzeslowski.jsupla.protocol.api.structs.ds.SuplaDeviceChannelB;
import pl.grzeslowski.jsupla.protocol.api.structs.ds.SuplaRegisterDeviceC;
import pl.grzeslowski.jsupla.protocol.impl.encoders.PrimitiveEncoderImpl;

import static java.util.Objects.requireNonNull;

public final class SuplaRegisterDeviceCEncoderImpl implements SuplaRegisterDeviceCEncoder {
    public static final SuplaRegisterDeviceCEncoderImpl INSTANCE =
            new SuplaRegisterDeviceCEncoderImpl(PrimitiveEncoderImpl.INSTANCE, SuplaDeviceChannelBEncoderImpl.INSTANCE);
    private final PrimitiveEncoder primitiveEncoder;
    private final SuplaDeviceChannelBEncoder deviceChannelBEncoder;

    SuplaRegisterDeviceCEncoderImpl(PrimitiveEncoder primitiveEncoder,
                                    SuplaDeviceChannelBEncoder deviceChannelBEncoder) {
        this.primitiveEncoder = requireNonNull(primitiveEncoder);
        this.deviceChannelBEncoder = requireNonNull(deviceChannelBEncoder);
    }

    @Override
    public byte[] encode(SuplaRegisterDeviceC proto) {
        byte[] data = new byte[proto.size()];
        int offset = 0;

        offset += primitiveEncoder.writeInteger(proto.locationId, data, offset);
        offset += primitiveEncoder.writeBytes(proto.locationPwd, data, offset);
        offset += primitiveEncoder.writeBytes(proto.guid, data, offset);
        offset += primitiveEncoder.writeBytes(proto.name, data, offset);
        offset += primitiveEncoder.writeBytes(proto.softVer, data, offset);
        offset += primitiveEncoder.writeBytes(proto.serverName, data, offset);
        offset += primitiveEncoder.writeUnsignedByte(proto.channelCount, data, offset);
        for (SuplaDeviceChannelB channel : proto.channels) {
            final byte[] channelBytes = deviceChannelBEncoder.encode(channel);
            offset += primitiveEncoder.writeBytes(channelBytes, data, offset);
        }

        return data;
    }
}

redpajama_set_name: RedPajamaGithub


8 Best Hunting Backpack Reviews 2019 - Which Could Carry Everything?
Hunting is in full swing and pretty soon we'll be hearing stories from our friends about the game they got over the weekend. Getting in on the action is always exciting, but in order to do so it is best to be prepared for some slow days and long walks. Carrying meat back home can be difficult as well and having the proper bag to get the job done is helpful.
In addition, think about the times you've spent waiting for hours in a stand or a blind without a single target to speak of. Its times like this that you're grateful you brought some snacks with you, or maybe you're grateful for the extra gear you brought along in case it gets cold.
Whatever it is that you bring into the woods in order to keep yourself comfortable and high spirited in addition to what you bring out of it, you're going to need to be able to carry it all in something; and believe it or not, there are backpacks designed specifically for these kinds of situations. The best hunting backpack can handle all of these tasks.
We've compiled a list to make your search for the right bag easier. Below are the top 8 hunting backpacks from this year.
The Alps Outdoorz Pursuit Bow Hunting Backpack is a moderate sized bag of 2700 Cubic Inches, with a bow pocket and a large front. It has a handful up other pockets and features including a pocket for your water bottle, a center aluminum frame stay that provides stability, and a rain cover.
A nice amount of room, security and stability, and quality features make this a good bag for your next hunting trip.
The Badlands Pursuit Lightweight Hunting Backpack is only 1800 cubic inches but it comes with two pockets, two water bottle pockets and multiple additional compartments. It is ideal for lightweight needs and stowing small gear and game. A nice bonus is that this bag comes with a lifetime warranty.
If you take longer treks for hunting excursions and don't rely on a ton of gear then a lighter bag like this one is a good choice.
This is an inexpensive option for small game situations. The bag is 1450 cubic inches and is ideal for users just looking for something to hold their smaller extras and accessories. If that sounds like you then go for this bag, it's worth spending less money.
However, this bag simply won't do for anyone who needs space. It's simply not big enough for those who rely on a lot of gear or space to haul game.
The Buck Commander Black Gorge Pack is demonstrates versatility at its finest. It looks like a small bag but it expands to 3515 cubic inches. This makes for a multipurpose bag because it can be condensed to allow for mobility and can function as a lightweight bag, while also offering the option to expand and carry a sizeable amount of gear. It also includes a pull out blaze orange panel for safety in the field, making it one of our favorites on this list for its multiple unique features.
The Alps Outdoorz Commander Freighter backpack is extra-large for bulky loads, but on top of that this backpack seems to just have it all. How about a quiver holder, a rifle holster, and a ton of space?
This backpack offers tons of features and plenty of room. The price isn't even all that high considering what you get from this bag. If you're hunter who appreciates these things and doesn't mind a little extra weight then this bag is right for you.
If you're serious about getting a heavy duty hunting bag that has a lot to offer then look no further. The Bounty 4500 is named for its 4500 cubic inches. With military-grade dual suspension and a detachable field pack, the Bounty 4500 is sturdy, durable and can be stripped down for lighter use.
There is also an included bow/rifle carrying system. The only issue with this bag may be the price tag it comes with.
3450 cubic inches of backpack stuffed full with gear doesn't have to be a pain in your back to carry around. The Badlands Sacrifice backpack is built with a "hybrid hypervent" suspension in order to keep the weight off your back.
It has 7 pockets, 2 compartments, and a top pocket that adjusts to make space for oversized loads. It is even compatible with bow, rifle, and pistol. This bag comes at slightly steep but it may be worth the added comfort, countless features, and plentiful space.
With front suspension opening bucket lid opening, this pack is easily accessible. It features a state of the art aluminum suspension and even a pocket to put your spotting scope.
The coolest features however include the built in rain fly and a meat shelf to keep your interior dry and provide a separate place to store your meat. Its accessibility, fair size, and many utilities make it a well-balanced option. The shortcoming with this bag is how expensive it is as it blows most of the other bags on this list out of the water as far as price goes.
When buying a hunting backpack you'll need to consider what sort of usage your bag will be getting.
Do you plan to use the bag to carry meat? If so then what size game are you planning to carry with the bag? Are you looking for a backpack that can stow your bow or gun? Maybe you're just looking for a small bag to carry a bit of gear.
In order to determine just what sort of bag you're looking for you'll have to keep these things in mind. You can narrow down your buying options quite a bit by judging what bags will match your needs by checking over a few factors.
The following, in particular, are the key factors that you want to look into when shopping for a new hunting backpack.
Size – You'll need enough space to carry your gear, meat, or any other additional items you prefer in order to leave your hands free. Get a bag that's sizeable enough to carry everything without being too large. A bag of around 2000 cubic inch bag will work fine if you don't bring a lot of gear but a bigger bag is often wise if you'll be in the woods for quite a while.
Mobility – You'll want a mobile bag that isn't too bulky or heavy to carry along with your other gear. Most bags nowadays are made with weight in consideration, but you'll just have to keep in mind that while the largest of bags will allow you to carry out larger quantities of meat, they are not always the most practical.
Additional Features – Extra pockets, pull-out safety panels, waist belts, and other additional features will add more functionality, safety, and comfort to your backpack. Gun holsters and bow pockets are wise. They can free up your hands if you find yourself having to (or getting to) drag a deer out of the woods.
The point in buying a backpack specifically for hunting is to have to proper additional features after all, so it makes sense to keep an eye on the extras. Again, the features you look out for should revolve around what kind of purposes you're buying your backpack for in the first place.
Price – This is a given. Read reviews and ask friends, and make sure you get your money's worth. A good backpack is worth laying down some money but you have more important things to spend your money than some designer backpack.
There may be a bit of give and take when all of these factors come into play, but overall you should be able to find a bag that suits you pretty well.
Once you are hooked up with a new bag the rest is up to you. You'll have the freedom of having everything you need right on your back and the ability to pack up meat with ease in your new backpack. Enjoy the hunt and remember to practice safe hunting technique. Good luck and happy hunting.
Best Spotting Scope Reviews 2019 – Which is for Hunting, Birding?


← The Hate U Give: Super. No clickbait. Just super.
I think I'm done with Liane Moriarty. I had a lot of fun reading Big Little Lies, and Truly, Madly Guilty and I had fun reading this one, too. But it's all the same book and the same reading experience: rich, white ladies encounter some soft tragedy and have their Tupperware selling businesses disrupted as a consequence. Okay, it's not charitable (or accurate, I guess) to suggest the novels are pure fluff. Each one has some thread of interesting moral quandary to sort out (in this one it's the question of whether you'd turn in your partner because it's the right thing to do even if it meant disrupting your own life, too) and the books are reasonably well written. I guess I'm just done with pretending like the drama faced by these super privileged characters is anything approximating substantive social commentary or inviting genuine emotional connection. It's more akin to watching well produced television with glossy sets full of artisan pottery dishes and buckets of fresh cut flowers on every available surface, complete with the cast of freckled munchkins and a stay-at-home dad with a dish towel over one shoulder and an well-timed humour. Meanwhile the women struggle to have it all, and do it all, and be it all and I'm just not interested. anymore. I really did enjoy the first few books by Moriarty, maybe because I could delude myself into thinking they had substance… All this said I'd still say if you're packing for a flight or the cottage or a weekend with your in-laws, there's a lot of enjoyment to be had in slipping in to one of these books. Just be prepared to come out the other side feeling like your teeth are fuzzed over.


Welcome to the Donald C. Harrison Health Sciences Library! In 2014 our Library was ranked 14th among the most impressive university medical school libraries in the world according to The Best Master's Degrees Reviews and Rankings. I invite you to enjoy our space, explore our resources, and to engage with our excellent staff. We are here to empower discovery, stimulate learning and inspire the creation of knowledge by connecting students, faculty, researchers and scholars to dynamic data, information and resources.


7 Halloween parties happening in Oman this weekend!
It's getting to that spooky time of year, so get a bed sheet out, cut 2 holes in it and dress up like a ghost - because it's Halloween! All across Oman parties will be taking place, but it's up to you to pick which party you go to!
The event is free for members, and RO10 for non-members, fancy dress is compulsory and the best dressed will win a prize. Live DJs, drinks and food will also be at the event.
If you dress to impress you will win!
Food and drinks will be on offer, music and a spooky atmosphere - It's Halloween, what else would you need?!
There will be a live band performing, food, drinks and spooky going on all throughout the night! Plus, the best dressed will win prizes.
Costumes are seriously mandatory this Friday at Laval, if you're not wearing one, you're not getting in! There will be live DJs, drinks and food - plus prizes for the best dressed!
They have made it very clear, halloween loved surprises - and so do they! So don't be shocked if you head to Rumba Lattina this Friday night and get the fright of your life!
If you dress up, you get a special treat (They haven't disclosed what the treat is, maybe it's a trick!) They have also stated that mayhem and mischief is expected!
If you share their Halloween Facebook event, you have a chance of winning an iPhone 7, so that's pretty cool! Dressing up to the fullest is mandatory, and the winners of their best dressed competition will get the chance to take a photo with Carlos Rily a Michael Jackson tribute, who is performing on the night!


Through market research, businesses gain a truer understanding of the market they operate in. It's an important marketing tool used in the development of a business's strategy.
For larger businesses it is a key tool used to keep the key decision makers in touch with market developments. Smaller companies can still benefit from the process by adding some structure.
Segmentation – Age, Gender, Wealth, Education, Interests etc.
Image – does it perform, is it reliable etc.
Depending on the business, there may be more, some will only need to look at a few areas.
Market Research can use a broad range of tools and techniques.
This covers the more mathematical processes such as the analysis of customer surveys. Most of us are familiar with being quizzed about a product or service. Somewhere hidden away, this data will be analysed and quite likely presented in graph form at some stage to management.
In many industries, market data can be bought from specialist companies. This allows you to calculate your market share shows market size trends.
Modelling using tools like Excel enable you to plot market and product trends, adding different scenarios and "what ifs." Tools can be extended to indicate turnover and profitability forecasts.
This complements Quantitative Research. Whilst the numbers may ultimately give a go/no go decision, the more human factors needs covered here, point you in the direction you need to travel and/or tell you if you are on the right road.
Exhibitions although primarily sales focussed are also good for getting customer feedback. If competitors are present at the show, you also get an indication of how well you compete.
Focus Groups are a classic tool, getting a group of potential and existing clients together will provide valuable information on market needs, its direction, product needs and how well you are doing. There are risks, the process may expose your bad points and customers may be made aware of competitors advantages. To be effective, the group needs to represent all segments of the market, avoid the trap of just inviting friendly long term customers. Industry experts can be valuable members in a group, they have the benefit of helicopter vision.
Online surveys are easy to implement using email, both your own and possibly external prospect databases where Web-Clubs can help. By using Survey Monkey, simple online surveys are easy to implement.
Industry associations are good place to look for market data, if they have it available it is likely to be cheaper to buy than from specialists analysts.
Keeping in touch preferably face to face, but at least by telephone keeps you aware of market developments.
If you are unsure how to proceed, and particularly if you are thinking of entering a new market, using a specialist agency such as Insight Engineers may be justified.
Meeting over a coffee or something stronger with knowledgeable customers or industry experts is worth a small investment. Away from the working environment in a casual setting you are more likely to get honest feedback.
Exhibitions, Seminars and even Web conferences allow you to find out what competitors and influential players in a market are doing. For some businesses local networking groups can be valuable.
Gathering the information is one thing, putting it to use is another! It is important that all data, both quantitative and qualitative are recorded. Graphs are much easier to interpret than tables of numbers, fortunately, they are easy to produce in Excel.
With more qualitative issues, pick out the key statements and points.
Many years ago I was part of a team evaluating a planned new software product. After several weeks most of us in the team concluded the product wasn't going to be competitive. We presented our findings and very nearly all lost our jobs, it didn't go down well! The product went ahead, many thousands more dollars were spent only for it to be discontinued eighteen months later.
Good Market Research will stop you for making those mistakes. Importantly it will signal that you may need to change direction if your existing market and product is dying. Ignoring the issue will not help!


text:
Bluepoint Games Looks To Be Debunking PlayStation Acquisition Rumors As Leak Suggests Reveal Is Imminent
Recently, Sony confirmed that it was adding Housemarque, the studio that gave us Returnal, to its growing network of PlayStation-owned studios, but that confirmation came with a little more than intended. PlayStation Studios Japan accidentally used the wrong image in its now-deleted tweet about the Housemarque. The image used was the same one that welcomed House into the mix, but instead, the words on said image read Bluepoint Games. This get would also be a good one to celebrate, given Bluepoint's talent at crafting and recrafting excellent experiences, especially in the realm of remakes such as Shadow of the Colossus. Still, Bluepoint itself is saying "not so fast" – even with a recent leak that suggests an acquisition announcement is imminent.
The team over at Bluepoint Games has done a few things to combat the acquisition rumors that followed after the image went viral. The most immediate change can be seen in Bluepoint's Twitter profile that now reads: "Bluepoint Games is a fully independent self-funded studio. We are always looking for talented engineers, artists, and designers to join the team."
At the tail-end of June, Bluepoint Games also posted a link to its Career Page, showcasing several roles the studio is currently hiring for. The same emphasis on the nature of the studio is "fully independent," and "self-funded" can be seen in many of those roles, which seems to be a passive way to parry that acquisition speculation.
Contradicting this verbiage, XboxEra co-founder Nick Baker claims that an upcoming Sony Showcase will reveal the alleged Bluepoint acquisition:
So it seems Sony Japan Twitter already spoiled this surprise? Because I was just now told the surprise was Bluepoint being acquired https://t.co/rQChxA6O4B
— Nick (@Shpeshal_Nick) July 5, 2021
The team hasn't addressed the acquisition outright with a statement at this time. Still, the detailed precision that Bluepoint is making when adjusting how it is presenting itself and opportunities seems to be making that point regardless. What this means for the future is up in the air; plans can always change, solid offers can always be made, but at this time? It looks like the acquisition leak from Sony may have just been human error or wishful thinking, but it looks like we'll be learning something more official soon enough.
What do you think? Do you think this is Bluepoint's way of firmly staunching acquisition talk, or are we looking too much into it? Sound off with your thoughts in the comment section below!
PrevCanceled Mass Effect Game For Nintendo DS, Corsair, Would Have Players As A "Han Solo" Kind Of Pirate
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redpajama_set_name: RedPajamaCommonCrawl


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Q: How much better is the WPF Designer in Visual Studio 2010? For those who have spent time in Visual Studio 2010, and work with WPF, how much better, if any, is the designer for WPF? Are other designers, such as Blend, still preferred, or can we be productive in VS 2010?

A: The WPF Designer in VS 2010 is hugely improved over the one in 2008.
It handles many more unusual cases without breaking, and does a better job overall.
That being said, with a few exceptions, it's still the same fundamental design as the 2008 designer.  There are some new features, particularly for auto-generating forms based on data, etc, but overall, it works the same way.
As a result, I still find Blend a much nicer tool, overall, for working with WPF from a designer standpoint.  I'm just very happy that the designer doesn't "break" as often, especially when doing things like using Blend behaviors, etc.

A: VS2010 WPF designer is much closer to the level of WinForms designer than it was in VS2008 - I would say it will suit typical programmer quite well. However Blend is still needed if you are a designer.
Also, I found VS2010 designer much more stable than VS2008 SP1 one. Not a single crash so far.

redpajama_set_name: RedPajamaStackExchange


Because reports don't lie! At the end of every month, we build a social media report for your brand to see the progress it has made over the past month. We always aim to reach our goals for your brand and by viewing the reports and analytics, we can see what areas need more focus on and which areas are doing really well.
We create your custom report.
We analyse the report and build up a summary for you.
We see which areas need more or less attention and we execute that strategy into the following month.


The trailer for Ultra Big Celebration Soundboard is here….the app was released a few months ago, but……hey look it's a to the point app trailer for an awesome sound effects app! I bought an excellent piece of software called Reflector a couple of days ago, and now my life has changed in regards to videos for my apps. Seriously, Reflector is awesome and I regret not checking it out earlier. This is my first trailer using it and I can't wait to use it for my next apps. Ceeeelllleeebrate good times, come on!


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Indianapolis News and HeadlinesPublic Safety
Citizen reviewers work to make IMPD body cam footage 'easier to understand'
A group of Indianapolis citizens review police body-worn camera footage of officer-involved shootings before videos are released to the public.
By: Rafael Sánchez
INDIANAPOLIS — They are the regular citizens who review the Indianapolis Metropolitan Police Department's body-worn camera video before it's released to the public.
IMPD released eight videos showing police-involved shootings. Since October 2020, the videos have been first reviewed by a citizens group whose input is credited for improving the content that is made public.
The videos depict some of the high-profile exchanges between the public and police, and each is different.
IMPD Chief Randal Taylor and a group of 50 community members first meet online and on a set date, the group meets to see body-worn camera footage of a police-involved shooting before it's released to the public.
"We're being transparent as much as we can, especially in police-action shootings," Taylor said. "I feel the community needs to be involved in the work that we do, and they need to know personally what we're doing."
The group is given limited details about the situation. After the presentation, they get to work.
"I'm assessing what is verbally said, what is not being said — the actions demeanor, the level of rudeness, level of civility and seeing whether this was a good interaction between civilian and law enforcement," Ashley Gurvitz, a citizens review member, said.
People may ask for more videos from other officers to better understand what's happening, or they may ask for the addition of written words on a video to make clear what the officer or suspect is saying.
WRTV joined Taylor on the day the group was set to review video from a police-involved shooting that occurred May 29. In the incident, a man shot and injured an IMPD officer during a police chase.
Over time, the department says the group's feedback has improved the quality of the videos posted on its YouTube channel. The videos not only show what was caught on camera, but they can also help IMPD with the training of officers if a trend emerges.
"It's not perfect right, but we are leading to be in the right direction. With body cameras in place, we're moving in the right direction," Gurvitz said. "What this has actually done, I feel, is make it a little easier to understand what's happening on the other side."
RELATED | IMPD releases video of May incident when officer was shot


Maybe you just stand there and don't really know how to begin when you want to introduce yourself or someone else to an English native speaker. Your intention, however, was to leave a lasting first impression at the beginning of a conversation. The following phrases will help you to introduce yourself both casually and confidently. If someone is introduced to you, you may reply "Nice to meet you" and introduce yourself afterwards.
If you want to introduce an acquaintance, a friend, a relative or a colleague to someone, you may do so by using the following phrases.
The following video will show you an encounter of three people who introduce themselves to one another. Watch it and try to repeat the sentences in the second part.
At formal encounters, for example among business associates, you usually address someone with Mr. or Mrs./Ms., but when you introduce yourself, you normally leave out the titles. So you don't say "Hello, I am Mr. Smith." but "Hello, I am Marc Smith.". The doctor's degree can be used if you want to keep the relationship very official. You would then introduce yourself as "Dr. Tom Maier" for example. If you place no great value on titles, you can break the ice by saying "Oh, please call me Tom".
You can find more helpful tips for the beginning of a conversation in the article Greeting.


Fast & Free Lily Alan Walker K 391 Emelie Hollow MP3 download from Awesome MP3. We have found your song: Lily Alan Walker K 391 Emelie Hollow MP3 music. Matching your searches top 10 results from Awesome MP3. Now we recommend you to Start Free Mp3 Download Alan Walker K 391 Emelie Hollow Lily Lyrics MP3 which is uploaded by Shadow Music of size 4.32 MB , duration 3 minutes and 17 seconds and bitrate is 192 Kbps .


As American families cautiously celebrated the reported release of their loved ones from Iran, one has been "devastated" by the news that a former FBI agent was apparently "left behind."
"We are happy for the other families. But once again, Bob Levinson has been left behind," the Levinson family said on Facebook. "We are devastated."
Family members said that Levinson was part of the discussion with the government of Iran that eventually freed five Americans in Iranian custody and also ended in the clemency for seven Iranians in the U.S., but the Iranians denied knowing where Levinson was.
The 67-year-old Levinson, who served for more than two decades with the FBI before retiring, disappeared off Iran's Kish Island in March 2007. For years the U.S. government said Levinson was working at the time as a private investigator, but in December 2013 his family acknowledged that he was, in fact, working as a freelance "spy" for a rogue CIA operation.
Family attorney David McGee told ABC News then that he felt the CIA and the FBI had betrayed Levinson and tried to hide the fact that he had a long-term relationship with the CIA, spying on Iran's nuclear program and on the Lebanese terror group Hezbollah.
"The CIA sent Bob Levinson to Iran to do an investigation on its behalf," McGee said. "[R]ather than acknowledge what they had done and try to save Bob's life, they denied him."
Amid the news about the other Americans' release today, a U.S. official told ABC News, "Iran has also committed to continue cooperating with the United States to determine the whereabouts of Robert Levinson."
Iran has long denied it is holding Levinson, but U.S. officials previously have told ABC News they suspect that at the very least, officials in the Islamic Republic know where he is. Some U.S. officials told ABC News today that Levinson being left out of the highly-publicized prisoner release raises fears that he may not still be alive.
In January 2013, Levinson's family released a series of images of the then-64-year-old man, showing him draped in chains and dressed in what appears to be a mock prison uniform. In each he holds a sign, one of which reads "Help me." American authorities either do not know or have not publicly identified Levinson's suspected captors, but the U.S. government has repeatedly asked the Iranian government's help in finding him.


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"Pure Michigan" screen dedication ceremony held at Historic Vogue Theatre in Manistee
Kathy Fagan
Michigan Economic Development Corporation President and CEO Michael A. Finney today joined state and community leaders in dedicating the "Pure Michigan" screen at the newly-renovated historic Vogue Theatre in Manistee.
LANSING, Mich. –Michigan Economic Development Corporation President and CEO Michael A. Finney today joined state and community leaders in dedicating the "Pure Michigan" screen at the newly-renovated historic Vogue Theatre in Manistee.
"The renovation of this historic theatre into a vibrant entertainment venue will bring new vitality to downtown Manistee and serve as a catalyst for further positive activity in the community," said MEDC President and CEO Michael A. Finney. "This project, set in the heart of downtown, was achieved through the efforts of the entire community and is symbolic of the best Pure Michigan has to offer."
In May the Michigan Strategic Fund approved a $503,592 Michigan Community Revitalization Program performance-based grant for the redevelopment of the Vogue Theatre into a 235-seat movie theatre. The project included renovating both the interior and exterior of the building, making structural improvements, installing new sound and lighting equipment and new seating, and improving the surrounding sidewalks. The screen in the larger, 190-seat movie room was dedicated the "Pure Michigan" screen in recognition of the MCRP grant.
The two-year project is the largest volunteer-led, community-driven initiative in the history of Manistee. The City of Manistee Downtown Development Authority provided support to the project valued at $308,250 in the form of land contribution, locally committed grants and low interest loans. In addition, more than 650 individuals and organization have donated or granted funds for the $2.4 million capital campaign that has raised $1.9 million to date.
"The naming of the Pure Michigan screening area that will seat 190 people means that movie-goers for generations to come will recognize the statewide importance of the Vogue Theatre to Michigan's economic well-being," said Steve Brower, chair of the Vogue Theatre's capital campaign and Treasurer of the Historic Vogue Theatre of Manistee, the nonprofit that owns and will operate the Theatre. "MEDC stepped in at a time that was crucial to get the restoration work underway and encourage others to donate or make grants to make this dream a reality."
On December 6, 2013, a Vogue Theatre Sneak Peek movie event, packaged with dinner and an "afterglow," will be the debut for the Pure Michigan screen. The event is being hosted by the Historic Vogue Theatre of Manistee nonprofit. Event information is available at www.voguetheatremanistee.org. Tickets are available through MyNorth at (800) 836-0717.
Pure Michigan is a brand representing business, talent and tourism initiatives across Michigan. These efforts are driven by the Michigan Economic Development Corporation, which serves as the state's marketing arm and lead advocate for business growth, jobs and opportunity with a focus on helping grow Michigan's economy.
About Michigan Economic Development Corporation (MEDC)
The Michigan Economic Development Corporation is the state's marketing arm and lead advocate for business development, job awareness and community development with the focus on growing Michigan's economy. For more information on the MEDC and our initiatives, visit www.MichiganBusiness.org. For Pure Michigan® tourism information, your trip begins at www.michigan.org. Join the conversation on: Facebook Instagram LinkedIn, and Twitter.
Gov. Whitmer Announces 155 New Jobs Coming to Detroit, Genesee County
Leadership Change at the Office of Future Mobility and Electrification Announced
State of Michigan Kick-starts 2023 with Support for Placemaking Projects That Will Build Vibrant, Resilient Communities


Budayun (Uttar Pradesh), Feb 11, 2017: Prime Minister Narendra Modi renewed his attack on Uttar Pradesh Chief Minister Akhilesh Yadav on Saturday and charged him with presiding over chaos and lawlessness in the state in the past five years.
Addressing a gathering in Budayun, a Yadav stronghold, the Prime Minister said time has come to reverse the caste and community-based policy making in the state and instead embrace the 'Sabka Saath, Sabka Vikaas' policies of the Bharatiya Janata Party (BJP).
Reminding people that in the 2014 Lok Sabha polls, the region had not elected a BJP legislator, Modi said it was the central government which has brought electricity to 500-plus villages in Budayun which never saw light in the past 70 years.
"My focus is all-round development of an area and welfare of people, irrespective of caste, community and to which political alignment he or she is," Modi said while stating his government was committed to the poor, farmers, labourers and marginalised sections of the society.
He also took a jibe at Akhilesh Yadav saying he is so rattled, that at his election rallies, the 43-year-old leader was asking people if 'acche din' (good times) has come.
"By merely copying my style of interaction with the people, you don't achieve anything Akhilesh Yadav ji, you should answer to the people of Uttar Pradesh if good days were ushered in during your five years' governance," he said.
Taking potshots at the local SP MP and Chief Minister's cousin Dharmendra Yadav, Modi said a legislator of the ruling party himself has charged the MP of large scale 'gadbad' (irregularities) in the purchase of electricity wires and other contracts.
"The SP people are not interested in whether electricity comes to your home or not, they have reached where they had to go," Modi said in an apparent dig at the Yadav clan, which has more than 36 of its members holding political posts.
There is no electricity, no development, mis-governance and a complete lack of law and order in Uttar Pradesh and this will have to change, the Prime Minister said. He added that a month from now, on March 11, when election results would be declared, Uttar Pradesh will be celebrating a BJP-led government in the state.
He also touched on local issues in a bid to connect emotionally to the people and sought the blessings of the voters in the Yadav pocket borough.
Prime Minister Modi targeted the Congress-SP alliance and said leaders of these parties only a month ago were baying for each other's blood but now had embraced each other only with a single aim of stopping the BJP from coming to power.


Bookmaker William Hill has struck an agreement to buy 624 betting shops from rival Stanley Leisure - owner of Birmingham's Star City casino - in a deal worth £504 million.
Bookmaker William Hill has struck an agreement to buy 624 betting shops from rival Stanley Leisure - owner of Birmingham's Star City casino - in a deal worth £504 million.
The additional sites will be rebranded as William Hill and enable the company to overtake Ladbrokes as Britain's biggest bookmaker.
The deal, which will leave William Hill with 2,237 licensed betting offices, still requires the approval of shareholders and competition authorities.
A sale of the betting business, which trades as Stanleybet, would leave Stanley with its casino arm.
William Hill described Stanley's bookmaking estate as "highly complementary" with its own, as Hill is currently under-represented in areas such as the North-west.
The company also pointed out that the profitability of the Stanley estate was " substantially below" its own and offered opportunities for improvement, including through the addition of more fixed-odds betting terminals.
It added: "William Hill has significant experience of developing licensed betting offices and is confident it can upgrade and improve the quality and performance of the acquired estate over time. The UK betting market is highly competitive and, accordingly, the board believes that any potential competition issues will not be material."
William Hill confirmed it was scrapping plans to return £453 million to shareholders.
Stanley said the group would likely return about £300 million to its shareholders.
Finance director Colin Child said: "We hope to update shareholders shortly after this deal completes in mid-June."
"Stanley shareholders are getting the better deal," said analyst Greg Feehely at Altium Securities. "The price is mindboggling - 13.5 times historic EBITDA (earnings before interest, tax depreciation and amortisation)." Shares closed down 141/2p at 5101/2p.


Comprehensively amend the regulations in order to protect public health and groundwater.
Proposed (430) Stage complete. Comment period ended 5/31/1996.
Final (641) Stage complete. This regulation became effective on 7/1/2000.


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Feature reviews & previews
Screen Extra
Home > Festivals > Encounters 2015 Highlights&Programme
Encounters 2015 Highlights&Programme
Thursday 20 August 2015, by Abla Kandalaft
The Encounters Festival team have recently issued their press release! This is what awaits us in September:
Encounters launches series of new public events for audiences in 2015
Encounters Short Film and Animation Festival returns to Bristol from 15th to 20th September. This year audiences can expect five days of the best short films from 35 countries alongside a series of special big screen events, a comprehensive industry programme and FREE public screenings for all the family.
As Europe's leading short film festival, this year the Encounters Festival International Competition screenings present 219 short and animated films chosen from over 2200 film submissions. The 21 competition programmes each feature between 5 and 15 short films, from genres including live action, animation, music video, experimental, documentary and comedy.
Contenders are in the running for nomination for the top short film and animation accolades: the Academy Awards, BAFTAs and European Film Awards and Cartoon D'or, to which Encounters is a leading UK gateway.
How Film Can't Live without the Music by Huey Morgan: Tuesday 15th September 2015, 20:30
Examining how music has always been integral to motion pictures. Join revered musician and DJ Huey Morgan in this exclusive event as he explores a selection of films, using music as a focus and examining how some films just would not be complete without it.
Cartoon d'Or: Wednesday 16th September, 2015 at 11:00
An hour of animation not to be missed, the award for the best European animated short film, Cartoon d'Or rewards the best of the best. This programme will feature the winners from this year's competition in September, chosen by a jury of international experts. Launched in 1991, the first Cartoon d'Or went to British director Nick Park, still unknown at the time, for his film "Creature Comforts". Pop by and catch some shorts from the future stars of animation and some established greats.
Terry Jones presents Boom Bust Boom: Wednesday 16th September 2015 at 19:00
In association with Bristol Festival of Ideas, Encounters will see Monty Python's Terry Jones present his new documentary, a mix of live action, animation, puppetry and song, walking us through the history of economic crashes.
Crashes have been happening throughout history for centuries, from Tulip Mania in 1637 to the Wall Street crash of 1929. The 2008 economic crash shocked the world, but how did experts not see it coming? Are we able to recognise a bubble when we are in one? Will the cycle of boom and bust devastate us again in years to come? It argues that in order to change the economic system, we must start with education. Followed by a discussion with Terry Jones.
Short Matters: Wednesday 16th, Thursday 17th & Friday 18th September 2015 from 19:00, FREE
These FREE drop-in screenings will be shown on three consecutive evenings at Watershed during Encounters this year, featuring the nominees from 15 film festivals the short film category of the European Film Awards. Screened in three short film programmes on Wednesday, Thursday and Friday at Encounters this is your chance to watch all of the 2014 nominees for free.
... Why the Short Face?: Wednesday 16th September 2015 at 19:45 & Friday 18th September 2015 at 20:00
Presented here for the audience's delight is a fantastic mix of films, each with a funny take on life. There's a strong dose of dark humour thrown in for good measure. The first of two programmes is guaranteed to bring a smile, and a cringe, to your face. The second offers up a plate of humour and comedy, from a cartoon dog desperate for walkies to a dinner party that goes disastrously wrong.
New Love Programme
Encounters this year will feature two loved-up film offerings. These shorts have stories about relationships and the making and breaking of them, showcasing the bravery and skill to produce a piece on delicate and often painful subject matters. In the first of two collections of shorts, Pro-creations on Wednesday 16th September is a collection of raunchy films that will discover there are many euphemisms for sex and love. Meanwhile Pillow Talk on Thursday 17th September at 8pm will show films which excel with either gentle humour or artistic sensitivity.
Music Video: Thursday 17th September 2015 at 21:45
Back by popular demand...this collection of Music Videos offers audiences dazzling visual art, wild stories and animated adventures in sound, music and image, showcasing the best and most innovative examples in this groundbreaking genre of the short form from new and emerging talent.
Petite Perpetual Cinema: Saturday 19th September 2015 from 10:00, FREE, drop in screening
This year the 2015 Encounters Perpetual Cinema is turned over to the family audience and offers free, drop in viewing of a selection of top short and animated films which have been screened in the competition during the festival week. Watch a few or watch them all, it's up to you! Content is suitable for all ages.
More info at www.encounters-festival.org.uk
Twitter: @EncountersSFF / #Encounters21
Facebook: Encounters Short Film Festival
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Normal by Adele Tulli - Fragments 2019
Arab presence in Cannes 2019
Interview with Yann Berlier & Lola Cambourieu, directors of Automne Malade
ClermontFF2019 Interview with Jonathan Hodgson, director of Roughhouse
ClermontFF2019 Interview with Vincent Lambe, director of Detainment
ClermontFF2019 Entretien avec Vincent Lambe, réalisateur de Detainment (Garde à vue)
ClermontFF2019 Lobo Mauro, director of Mais Triste que Chuva num Recreio de Colégio
ClermontFF2019 Veljko Popovic, director of Biciklisti
ClermontFF2019 Thomas Elley, director of Bølger [Open Spaces]
ClermontFF2019 Swatted by Ismaël Joffroy Chandoutis
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Problem gamblers come from all segments of the population, live in all regions of the province and include men and women of all ages and all socio-economic backgrounds. In addition to gambling for entertainment or fun, people with gambling problems will often gamble alone, chase losses and gamble to escape from problems.
Symptoms of severe gambling problems include emotional distress such as anxiety, depression, difficulty thinking or problem solving, and thoughts of suicide. Physical distress related to problem gambling includes sleep and eating disturbances and an inability to refrain from gambling. Other difficulties include health problems, problems with family and social relationships, and employment or school-related troubles as a result of gambling activities.
The Problem Gambling Resources Network is committed to helping individuals and communities address gambling in a healthy and responsible way through public awareness, education, advocacy, prevention, treatment/referral and research.
impact the community & individuals.


An independently generated UID instance is unique over time with respect to the host it is generated on as long as the host requires more than one millisecond to reboot and its system clock is never set backward. A globally unique identifier can be constructed by pairing a UID instance with a unique host identifier, such as an IP address.
An address can be obtained for this host that is unique and constant for the lifetime of this object.
In 1.5, you have java.util.UUID which is less esotoric.
This is probably the preferred method.
If you need compatibility with 1.4 then the org.apache.commons.id.uuid is an option.
A simple numerical id, start at zero and increment by one.
See also this HowTo for unique numerical id based on the system time.


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Pistyn (; ) ist ein Dorf in der ukrainischen Oblast Iwano-Frankiwsk mit 4050 Einwohnern (2016).

Das erstmals 1375 schriftlich erwähnte Dorf wurde durch Salzgewinnung reich, erhielt 1756 das Magdeburger Recht und wurde zu einer Stadt, die das Recht auf Selbstverwaltung hatte.

Pistyn liegt auf  Höhe am Ufer der Pistynka (), einem 56 km langen, rechten Nebenfluss des Pruth. Das Dorf befindet sich 9 km nordwestlich vom Rajonzentrum Kossiw und 83 km südöstlich vom Oblastzentrum Iwano-Frankiwsk. Durch Pistyn verläuft die Regionalstraße P–24 und die Territorialstraße T–09–15.
Im Dorf befindet sich die Holzkirche Mariä Himmelfahrt von 1861.

Am 12. Juni 2020 wurde das Dorf ein Teil der neu gegründeten Stadtgemeinde Kossiw im Rajon Kossiw, bis dahin bildete es die Landratsgemeinde Pistyn (Пістинська сільська рада/Pistynska silska rada) im Norden des Rajons.

Persönlichkeiten
 Hanna Wassylaschtschuk, ukrainische Künstlerin der dekorativen Kunst (Kunstweberei) kam 1924 im Ort zur Welt.

Weblinks
 Webseite des Gemeinderates (ukrainisch)

Einzelnachweise

Ort in der Oblast Iwano-Frankiwsk
Rajon Kossiw
Ersterwähnung 1375

redpajama_set_name: RedPajamaWikipedia


text:
Q: What is a proxy? I've scoured the Internet, but I always see the word "proxy" attached to another word, like a proxy server or something. Someone else told me that proxies in relation to Hibernate has something to do with the ID of a table's element. But what does proxy in itself mean??

A: The word proxy refers to one entity acting in the place of another.  In context,

*

*proxy server: a server that acts as an intermediary between two machines.

*Hibernate proxy: instead of returning data, Hibernate generally return proxies that need to be called in order to get the data.
In both cases, the proxy provides certain benefits (caching results, delaying execution until necessary)


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Corporate Finance & Accounting Mergers & Acquisitions
The Corporate Merger: What to Know About When Companies Come Together
By Jonas Elmerraji
Mergers are situations often cloaked in mystery and confusion. Do you know what to do when a company you've invested in plans to merge with another company? In this article, we'll show you how to invest around mergers and the ups and downs of the process. (For more information, check out "Cashing In On Corporate Restructuring.")
A merger happens when a company finds a benefit in combining business operations with another company in a way that will contribute to increased shareholder value. It is similar in many ways to an acquisition, which is why the two actions are so often grouped together as mergers and acquisitions (M&A).
In theory, a merger of equals is where two companies convert their respective stocks to those of the new, combined company. However, in practice, two companies will generally make an agreement for one company to buy the other company's common stock from the shareholders in exchange for its own common stock. In some rarer cases, cash or some other form of payment is used to facilitate the transaction of equity. Usually the most common arrangements are stock-for-stock.
Mergers don't occur on a one-to-one basis, that is, exchanging one share of Company A's stock typically won't get you one share of the merged company's stock. Much like a split, the amount of the new company's shares received in exchange for your stake in Company A is represented by a ratio. The real number might be one for 2.25, where one share of the new company will cost you 2.25 shares of Company A. In the case of fractional shares, they are dealt with in one of two ways: the fraction is cashed out automatically and you get a check for the market value of your fraction, or the number of shares is rounded down.
Mergers vs. Acquisitions
While the two processes are similar, don't confuse mergers with acquisitions. While in many cases, the distinction may be more about politics and semantics, there are a lot of blue chips that make quite a few acquisitions while maintaining relatively low volatility. As a general rule of thumb, if the corporate leadership of the company in which you own a stake doesn't change much, it is probably an acquisition. However, if your company experiences significant restructuring, we're looking more along the lines of a merger.
The Merger: What To Do When Companies Converge
Understanding the Buyout Circumstances
The circumstances of a buyout can also be very important. The investor should get to know the nature of the merger, key information concerning the other company involved, the types of benefits that shareholders are receiving, which company is in control of the deal, and any other relevant financial and non-financial considerations.
While it may seem counterintuitive, owning the company that's being bought out can be a real windfall for investors. That's because if the company being bought has shown respectable performance and has good prospects for the future, a certain amount of goodwill may be involved.
Goodwill usually accounts for intangible assets, though if those assets weren't factored into the stock price when you purchased your shares of the company being bought, you can end up on top. Goodwill is a source of confusion for a lot of people, but essentially what it is the amount of money a company pays over the book value of another company to purchase it. And let's not forget that because intangible assets aren't always easily valued, you can expect that a certain phantom percentage of most companies that have goodwill on their balance sheets may be overvalued. While that's not a good deal for the guy who owns a few shares of the purchasing company, if you own the company being bought, this can be another win for you.
If the company you've invested in isn't doing so well, a merger can still be good news. In this case, a merger often can provide a nice out for someone who is strapped with an under-performing stock. Knowing less obvious benefits to shareholders can allow you to make better investing decisions with regard to mergers.
Importance and Consideration Regarding Your Vote
Keep in mind that a company's decision to merge with another company is not necessarily set in stone. If you're a shareholder in the company, the decision about whether to merge with another company is partially yours. The typical voting scenario for a publicly-held company will usually end with a shareholder vote on the issue of the merger. If your analysis and consideration tells you that a merger is a step in the wrong direction, or if it tells you that it might be a great financial opportunity, voting with your shares is the best way to exercise your power over the decision-making process.
Non-financial considerations can also be important when looking over a merger deal. Remember: it's not necessarily all about money. Maybe the merger will result in too many lost jobs in a depressed area. Maybe the other company is a big polluter or funds political or social campaigns that you don't support. For most investors, the concept of whether or not the newly formed company will be able to make you money is certainly a big deal, but it might be worthwhile to keep the non-financial issues in mind because they might be important enough to become deal breakers.
Analyze Financial Reports
Even though there aren't a lot of people who enjoy reading financial statements, examining key information for each company involved in the merger is a good idea. Look over and analyze the company if you're not familiar with it, and determine for yourself if it is a good investment decision. If you find that it isn't, chances are that the newly formed company won't be terribly good either.
When analyzing financial statements, make sure to look over the most up-to-date financial statements and annual reports from both companies. A lot can happen since the last time you took a look at your company's financials, and new information can be a key to determining what influenced the other company's interest in a merger.
Understanding the Changing Dynamics of the New Company
The new company will likely have a few noticeable changes from the original. One of the most common situations is the change in leadership. Certain concessions are usually made in merger negotiations, and the executives and board members of the new company will change to some degree, or at least have plans to change in the future. When you cast your vote for a proposed merger, remember that you're agreeing to adjoining conditions like leadership changes, as well.
Putting Your Information to Work
As mentioned before, when it comes down to it, your vote is your own, and it represents your choice for or against a merger. But keep in mind that, as a shareholder of an involved company, your decision should reflect a combination of the best interest for yourself, the company and the outside world. With the right information and relevant consideration of the facts, coming out ahead in the face of a merger can be a realistic goal.
Mergers vs. Acquisitions: What's the Difference?
Why Do Companies Merge With or Acquire Other Companies?
How Accretion/Dilution Analysis Affects Mergers and Acquisitions
Mergers And Acquisitions: Understanding Takeovers
How mergers and acquisitions can affect a company
Tools for Fundamental Analysis
Why Synergy Matters
Synergy is the concept that the value and performance of two companies combined will be greater than the sum of the separate individual parts.
Amalgamation: The Ins and Outs
An amalgamation is a combination of two or more companies into a new entity. Amalgamation is distinct from a merger because neither company involved survives as a legal entity.
How Mergers and Acquisitions – M&A Work
Mergers and acquisitions (M&A) is a general term that refers to the consolidation of companies or assets through various types of financial transactions.
Corporate Action Definition
A corporate action is any event, usually approved by the firm's board of directors, that brings material change to a company and affects its stakeholders.
A freeze out is an action taken by a firm's majority shareholders that pressures minority holders to sell their stakes in the company.
Proration Definition
Proration happens when available cash or shares are not sufficient to satisfy the offers that shareholders tender during a certain corporate action.


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Miscellaneous Scholarships
General Scholarships for Incoming Freshmen
General Scholarships for Currently Enrolled Students
Nadav and Nancy Baum Family Scholarship
This scholarship, created by two IUP alumni, provides assistance to undergraduate students with demonstrated financial need. No application is required.
Russell A. and Leah L. Berry Wilkinsburg High School Scholars Memorial Scholarship
Established in honor of Russell A. and Leah L. Berry to provide scholarship support to a graduate of Wilkinsburg High School (Pittsburgh, Pa.) who will attend IUP full-time and can demonstrate the self-reliance, maturity, and flexibility required to deal with the challenges and opportunities associated with IUP's academic programs. Preference will be given to the candidate who has maintained the highest academic standards while in high school. In the case where two or more candidates are equally qualified academically, financial need will be the determining factor. Applications are distributed to qualifying candidates.
Gloria J. Croft Bolinger Memorial Scholarship
Awarded annually to a graduate of Tussey Mountain High School. The Tussey Mountain administration and faculty select recipients.
Ruth Bowman Memorial Scholarship
A discretionary scholarship awarded to a talented and deserving freshman student. No application is required.
Colonial Motor Mart Scholarship
Established by the Spadafora family in honor of their employees, this scholarship is awarded to academically talented students enrolled at IUP who have graduated from an Indiana County high school. Preference will be given to children and dependents of employees of Colonial Motor Mart, Colonial dealerships, and Colonial Land Company.
Edith Davis Eve Foundation Scholarship
This scholarship is awarded to incoming first-year students of high academic merit who have financial need and reside in Blair County, Pennsylvania. No application is required.
Goldstrohm/Citizens' Ambulance Scholarship
Awarded to an employee or dependent of an employee of Citizens' Ambulance Service, Inc., who is actively enrolled as a full-time or part-time student. Applications are available at Citizens' Ambulance Service.
W.R. Hevner Family Scholarship
Larry J. Hevner, a 1970 graduate of IUP, started this scholarship to assist graduates of Harmony High School in Westover, Pa., who enroll at IUP. Representatives from Harmony High School select recipients.
Charles and Margaret Kupchella Scholarship
Established by the children of Mr. and Mrs. Kupchella, this scholarship is awarded to a graduate of Blacklick Valley High School who has enrolled at IUP. Representatives from Blacklick Valley High School select recipients.
Joseph and Judy Kovalchick Family Scholarship
Awarded each year to a graduate of St. Mary's, Pennsylvania, High School who attends IUP. Applications are available in the Guidance Office of St. Mary's High School. Recipient must be in good standing and a Pennsylvania resident. Representatives from St. Mary's High School select recipients.
Wells Fargo Endowed Scholarship for Academic Excellence (Pennsylvania State System of Higher Education)
The Wells Fargo Endowed scholarship for academic excellence provides financial assistance to incoming freshmen at State System universities who have achieved academic excellence in high school. Applicants must reside in one of the following counties: Allegheny, Berks, Bucks, Carbon, Chester, Cumberland, Dauphin, Delaware, Lackawanna, Lancaster, Lebanon, Lehigh, Luzerne, Monroe, Montgomery, Northampton, Philadelphia, Pike and York. Eligible applicants must have been in the top 25% of their graduating class in high school with a GPA of 3.2 or better. Students must also demonstrate financial need based on the FAFSA. Eligible applicants must complete an application by May 12, 2017 . For additional information, please visit http://www.thepafoundation.org/scholarship.php .
M&T Bank Scholarship (Pennsylvania State System of Higher Education)
M&T Bank has established a $1,000 scholarship for incoming freshman who reside in Cumberland, Dauphin or Franklin counties, will attend a PASSHE university, and are in strong need of financial assistance. Incoming freshmen applicants must be in the top 25% of their high school graduating class, and upperclassmen must have a GPA of 3.0 or higher. Eligible candidates are required to complete an application by June 9, 2017 . For more information, please visit http://www.thepafoundation.org/scholarship.php.
Thomas and Flora McGrainor Memorial Scholarship
Offered to a student from West Shamokin High School who lives in the surrounding Dayton, Pa., area (where students previously attended Dayton High School) and who will be enrolled as a full-time student at IUP. Recipient must demonstrate financial need, a 2.5 cumulative grade-point average, and involvement in extracurricular activities and/or community services. Selection is made by the scholarship committee at West Shamokin High School.
John W. McNaul Scholarship
Awarded to a graduating senior from Somerset (Pennsylvania) High School who will be attending IUP as a full-time student and who demonstrates financial need. Representatives from Somerset High School select recipients.
Frank E. Moore Family Scholarship
Awarded to a nontraditional incoming freshman who has graduated from an Indiana County high school or who has been a resident of Indiana County for one year and who does not meet or is not eligible for other private support. Maintenance of 2.25 grade-point average overall is required. Preference will be given to those with children. Applications are distributed to qualifying students.
Morino Scholars Award
Awarded to academically promising and financially deserving undergraduate students. Preference given to students from historically mining communities whose parents or grandparents are employees or retirees or expired while working in the mines, who are in the upper 10 percent of their high school class, who score 1100 on the SAT, and who demonstrate a financial need. Eligibility restricted to graduates of high schools located within Indiana County. No application required.
G. William and Julia Musser Scholarship
Scholarship is awarded to the most qualified incoming freshmen pursuing a pre-law major. Renewable if student maintains a 3.0 GPA. No application required.
Margaret M. Patton Foundation Scholarship
Established to assist students attending the university who are worthy and in need of such assistance. Preference will be given to students attending the IUP at Northpointe campus. No application required.
Joseph W. Serene Memorial Scholarship
Awarded to a graduating senior from Indiana Area Senior High School who has enrolled at IUP, has achieved a good academic standing (3.0 GPA), is active in school and/or community groups, and demonstrates good citizenship. Representatives from Indiana Area high School select recipients.
Robert R. Sheetz Memorial Scholarship
Created to honor the memory of a 1971 graduate of IUP, this award is presented to an incoming freshman student pursuing a degree that will lead to a career that will serve the public good. Preference is given to graduates of Greensburg High School and residents of Westmoreland County. No application is required.
The Stephen and Sandy Sheller Scholarship for Women of Tomorrow (WOT) in Philadelphia (Pennsylvania State System of Higher Education)
The Stephen and Sandy Sheller Scholarship for Women of Tomorrow (WOT) is funded to provide tuition funding for high school graduates of the WOT in Philadelphia program. Applicants must be a graduate of the WOT in Philadelphia program and be pursuing an undergraduate degree with a 3.0 GPA. Eligible candidates must complete an application by April 14, 2017 . For more information, please visit http://www.thepafoundation.org/scholarship.php.
Sons of Italy Recreative Club, Inc., Scholarships
Scholarships are awarded to graduates of Indiana County schools, with the exception of Homer-Center, who enroll as full-time students at IUP. Applications are distributed to qualifying students.
Michael J. Supinka Jr. Memorial Scholarship
Awarded to a full-time entering freshman who is a graduate of Homer-Center High School and who demonstrates academic excellence and leadership qualities. No application required.
Tomb Family Scholarship Fund
A discretionary scholarship awarded to a talented and deserving freshman student enrolled full-time at IUP in a program leading to a baccalaureate degree. No application is required.
West Branch Area High School Scholarship
Awarded to graduates of West Branch Area High School, Clearfield County (or any named successor created by a consolidation of high schools), who demonstrate financial need and positive academic achievement. Representatives of West Branch High School select recipients.
Luhelen Grace Whisner Memorial Scholarship
Awarded to a student from Westmoreland County, Pennsylvania, who demonstrates academic promise, good citizenship, and financial need, and who receives no other private scholarship support from IUP for academic or athletic performance. No application is required.
Coraopolis Wolves Club Den IX Scholarship
Provides a scholarship to full-time undergraduate students who graduated from Moon, Cornell, or Montour school districts and who are in the upper quarter of their graduating class. Awards may be renewable based upon maintenance of good academic standing and availability of funds. Recipients are selected by the Coraopolis Wolves Club Scholarship Committee based on a listing of eligible students who meet the criteria. No application is required.
200 Clark Hall
financial-aid@iup.edu
Service Counter Hours


Review of the 1983 Brainstorm movie with Christopher Walken.
When I grew up in Hungary the celebrity culture was much less pervasive and aggressive than it is now. One of the first time I heard or paid attention to a filmstar was when my grandmother, a journalist working for a women's weekly was excited and upset about the mysterious death of a movie star. The circumstances of her death were fascinating to my 13 year old self: falling of a boat in the ocean in an intoxicated state. I also remembered the name of the actress although I did not recall seeing her in anything: Natalie Wood.
After I just watched the last movie she worked on I read up a bit on her. Turns out she didn't even have a chance to finish all her scenes for Brainstorm, for some scenes a look and sound-alike was used. But enough about the people in and behind the movie. Let's focus on the technology as most of the film seems to be doing. It was made in 1983, when my father was working at an Apple store in Oakland and discovered the power of modems. The same year I was learning how to use punchcards on antiquated Soviet computers in high school. Compared to my experience at the time the movie would have been truly futuristic, but compared to my father's I am less sure. However looking back from what we have now, 29 years later, it is so simplistic. That's the danger of putting tech first into a sci-fi movie It is bound to look stupid a few years later.
I can't and should not accuse this movie of having tech for tech's sake, because it had plenty of interesting ideas too. But they were overshadowed for me by the presence and effects of gadgets. The title is misleading though. It is less about turning brainwaves into brainstorms and more about the consequences of surfing on other people's brainwaves.
Having said all of the above, I still enjoyed the movie despite that its logic was tangled and the viewer had to work on it to figure out the sequences and causalities. It had intriguing concepts, good acting (e.g.Christopher Walken) , and a fascinating insight into the future that didn't happen (yet).
Remastered DVD and Video on Demand @ Amazon.com.
IMDB's summary: Brilliant researchers Lillian Reynolds and Michael Brace have developed a system of recording and playing back actual experiences of people. Once the capability of tapping into "higher brain functions" is added in, and you can literally jump into someone else's head and play back recordings of what he or she was thinking, feeling, seeing, etc., at the time of the recording, the applications for the project quickly spiral out of control. While Michael Brace uses the system to become close again to Karen Brace, his estranged wife who also works on the project, others start abusing it for intense sexual experiences and other logical but morally questionable purposes. The government tries to kick Michael and Lillian off the project once the vast military potential of the technology is discovered. It soon becomes obvious that the government is interested in more than just missile guidance systems. The lab starts producing mind torture recordings and other psychosis inducing material. When one of the researchers dies and tapes the experience of death, Michael is convinced that he must playback this tape to honor the memory of the researcher and to become enlightened. When another researcher dies during playback the tape is locked away and Michael has to fight against his former colleagues and the government lackeys that now run his lab in order to play back and confront the "scariest thing any of us will ever face" – death itself.
This entry was posted in Film/TV on February 1, 2011 by Gabor Por.


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Corsages and Buttonholes
Luxury Heirloom Cards
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Pauline Forde started her career as a florist, training at the Dessie Banks School of Floristry in Dublin at the age of 16. She worked in the flower industry for many years to follow and became renowned for her work both as an artist and florist. In the years that followed, Pauline experimented with many textures and forms and in 2008 put her creative energy into fashion design and set up her own business designing ladies handmade accessories such as bags, belts, hats and jewellery. As her work took off she spent the next few years working on private commissions and selling her pieces to many high-end boutiques in Kildare.
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Play kitchens are great for kids social interaction and pretend play. Here's a list of the best play kitchens in 2017. Kids will love these!
Which are the Best Play Kitchens in 2017? Find out here. Take a few seconds and easily compare several top rated Play Kitchens.
By Daisy | What are the best play kitchens this year? Find out here. Take a few seconds and easily compare several top rated play kitchens your kids will love!
Explore the board "Best Play Kitchens" on Pinterest, the world's catalog of ideas.
A selection of the best play kitchens that are loved by kids and their parents.
Play kitchens stimulate a child's imagination, encourages social behavior and creates pretend play. Here are the best play kitchens for kids this year. They are sure to love these!


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Home Regional Grenada Grenada to host promotional cricket tour in United Kingdom with 20-player team
Grenada to host promotional cricket tour in United Kingdom with 20-player team
The 20-player team, 'Grenada 11', consists of a mix of cricket legends, including Devon Smith, Andre Fletcher, and Junior Murray as well as emerging young players.
Grenada: In an effort to cement itself as a leading sports destination, the Grenada Tourism Authority (GTA) and the Grenada Cricket Association will host a promotional cricket tour in the United Kingdom (U.K).
The 20-player team, 'Grenada 11', consists of a mix of cricket legends, including Devon Smith, Andre Fletcher, and Junior Murray as well as emerging young players.
The team departed the Maurice Bishop International Airport on Wednesday evening. Before departure, Minister for Youth, Sports & Culture Hon. Ron Redhead, met with and bade the team farewell and reminded them to be Ambassadors for the destination.
The Grenada 11 will appear in a number of games and appearances, with matches against teams including the Club Cricket Conference (CCC), United Kingdom Armed Forces Cricket Association (UKAFCA), and Hertfordshire County Cricket Club.
It will also face Northamptonshire in a 50-over game. This match will take place less than two weeks after Northamptonshire County Cricket Club hosted India prior to their Twenty20 series against England.
In addition, the GTA will showcase traditional Grenadian entertainment including live music and Spicemas carnival costumes, as well as food and drink.
Westerhall Estate, a Grenadian producer of rum, will provide a lively bar set up at the games. It lasts until 6 August 2022.
Earlier, players of Grenada also participated in the ongoing World Athletics Championships. Kirani James chased men's 400m glory in the semifinal round of the World Athletics Championship 2022 at Eugene, Oregon.
Grenada's Kirani James blasted through his 400m semifinal comfortably, clocking a time of 44.74. He now goes to his fifth 400m. His World final are; 2011, 2013, 2015, 2019, 2022. Kirani James clocked 44.74s to take the second semifinal of the men's 400m ahead of Bayapo Ndori who came through for 2nd in 44.94s, both of them swapping positions from the heats. Muzala Samukonga clocked 45.02s to take 3rd.
Dickon Mitchell
Government of Grenada
Prime Minister Dickon Mitchell
Prime Minister of Grenada
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