Welcome to our free interactive online marriage matching service. This Kundali Matching service helps you to find right partner based on your birth details. This Koota matching tool will give you details of matching based on astha koota matching system and it is also checks kuja dosha (mangal dosh, manglik) along with dosha nakshatra (Vedha nakshatra) and also gives you score and suggestions regarding compatibility. Now you can find analysis of married life and child birth doshas and favorable planetary placements and results of kutas. This is the only online tool which checks Vedha nakshatras along with Kuja dosham. This Match Making software also checks exeptions of Eka Nadi dosha and Rashikuta Dosha. You can select South Indian and North Indian Kundali style to check birth charts for marriage matching. Fill birth details of male and female and submit to check marriage match compatibility. In north india it is called as Kundli Milan or Patri milan and in South India, In telugu Language it is called as Vadhu Vara Guna Melanam, Jakata Pontana, in Tamil Language it is called as Tirumanam poruntum, in Malayalam Language it is called as vivaaham pearuttappetunnat and in Kannada language it is called as Maduve hondanike.
This is a Vedic compatibility check. This helps us to find a right life partner. We use Vedic Asta Kuta method to analyze compatibility between boy and girl. This method uses birth star and birth sign.
What details we need to check compatibility?
For basic compatibility, we need Rashi and Nakshatra of boy and girl. but for detailed analysis, we need birth details, i.e., date of birth, time of birth and place of birth details of boy and girl.
This is a Vedic compatibility method used in major part of India. This method tells about compatibility based on 1. Varna koota, 2. Vashya koota, 3. Tara koota, 4. Yoni koota, 5. Graha maitri koota, 6. Gana koota, 7. Rashi koota or Bhakoota and 8. Nadi koota. each koota signifies about various areas in married life. Varna koota tells about an understanding between the couple. Vashya koota tells about trust of the couple on each other. Tara koota tells about the longevity of married life. Yoni koota tells about prosperity and financial status of the couple. It also tells about the physical attraction between the couple. Graha Maitri koota tells about family and home. Gana koota tells about mental compatibility between the couple. Rashi koota tells about happiness between the couple. Nadi koota tells about physical compatibility and child birth.
Is this method only enough to finalise marraige?
What are those main doshas which may cause problems in married life?
There are so many doshas/ ill placement of planets which may cause problems in married life. Kuja dosha or Mangal dosh. sarpa dosh. Sukra dosh. Papa kartari dosh. etc. we need to check carefully birth charts before finalizing the marriage.
How to come out from these doshas?
There are so many Vedic remedies for these doshas which help couple to lead happy married life. Please consult a learned Astrologer before taking final decision about marriage.


text:
Hyperthermia Therapy
Hyperthermia is one of the most powerful anticancer, antiviral, and antibacterial therapies available, yet it is underutilized and largely unknown in North America. Hyperthermia treatment involves raising the temperature of the whole body, or of local areas of the body to 39 to 43 degrees C (102 F to 109 F). Research has shown that high temperatures stimulate cellular immunity and can damage cancer cells, usually with minimal injury to normal tissues.1, 2, 3, 4, 5 By damaging proteins and structures within cancer cells, hyperthermia may shrink tumors.6 In general, malignant cells are more sensitive to heat than are normal cells in the range of 41-45°C. In addition, most clinically apparent tumors (above 1-cm diameter) have blood perfusion rates less than 1/5 that of surrounding normal tissue, meaning that they may be preferentially heated. In Europe, hyperthermia is considered the 4th major modality of cancer therapy along with surgery, chemotherapy, and radiation. And in Europe, hyperthermia is often utilized as an adjunctive therapy with various conventional cancer treatments, such as chemotherapy and radiotherapy, but in some clinics, is also used alongside biological regulatory therapies.7 As hyperthermia is non-myelosuppressive and can potentiate the tumoricidal effects of biological regulatory therapies, its use as part of a multimodality treatment approach is attractive. The positive results of randomized trials have established hyperthermia alone, or in combination with biological regulatory therapies, as an effective clinical modality for the treatment of cancer.
Temperature is a highly conserved and important parameter in all living systems. In mammalians, particularly in humans, a narrow range of 37.0 – 37.5 °C is attempted to be maintained by regulation. In this range, the complicated cellular and physiological processes work most efficiently. Under stress conditions, e.g. infectious diseases, fever is a reaction of the organism to better handle external attacks. Hence, fever is a natural defense reaction of the human body. The immune system's defense cells work best at a temperature above 39 degrees Celsius (102 F.). At this temperature, all metabolic and detoxification processes are intensely stimulated. This helps overcome infections, inflammations and pain much quicker and more effectively. During fever, the build-up of perspiration activates the excretion of toxic substances. This purifies the body and improves metabolism and after the fever subsides, the body relaxes, and the pain disappears.
The following are complementary effects of fever:
Increase in blood circulation and oxygenation of tissues
Acceleration of metabolism, detoxification, and excretion processes
Relaxation of muscle tension
Increased stimulus conduction of nerve fibers
Stimulation of cellular immune defenses
Inactivation of chronic bacteria and viruses
Hyperthermia treatment may be local (tumor only), regional (e.g., a limb), or whole body. Physical techniques for hyperthermia include metabolic heat containment, conduction through the skin (e.g., hot water bath), perfusion of externally heated blood, heated intravenous fluids and anesthetic gases, ultrasound, and electro-magnetic EM coupling modalities. Thermometric requirements vary with the treatment modality and clinical situation. Until the late 1990s, the use of radiant whole-body hyperthermia (WBHT) was restricted to a few specialized treatment centers worldwide. During the last decade, a larger number of WBHT-devices were put into operation particularly in Germany. Worldwide, hyperthermia is becoming more utilized clinically, due to the substantial technical improvements made in achieving selected increase of temperatures in superficial and deep-seated tumors. In North America, however, it is rarely used, and then only as part of an alternative cancer treatment protocol or research project.
History of Hyperthermia
Fever as the imminent sign of infectious diseases has been used as a diagnostic indicator since ancient times. The effectiveness of heat as a therapy against disease is believed to be known since 3000 B.C.8 Parmenides, a Greek physician and philosopher 2500 years ago said, "Give me a chance to create a fever and I will cure any disease." Fever is one of the body's best defensive and healing forces, created and sustained for the purpose of restoring health. Belief in the curative effect of fever was also shared by Celsus, a Roman author of the first systematic treatise on medicine "De Medicina," and Rufus of Ephesus, a Greek physician who lived at the turn of the 1st and 2nd century. Celsus described the hot baths as a tool in the treatment of various diseases.
There has been a historic, cross-cultural recognition of the benefit of fever and heat therapy. The healing effect of heat was first mentioned in the early civilizations of ancient Egypt, where baths in hot desert sand were prescribed for the ill. Doctors of ancient Greece started using this therapeutic approach and named it "overheating" (in Greek: hyperthermia). Other examples are the Roman sulfur hot baths, Finnish saunas, Japanese hot baths, Native American sweat lodges, and the many therapeutic hot springs in Europe, Iceland and in the Americas. Saunas and hot baths do not significantly increase core body temperature enough to have an anti-cancerous effect, but they have been shown to stimulate the immune system. More technologically innovative approaches have developed that increase core temperature or local temperature of tumor tissue to levels that damage or destroy cancer cells.
Bacteria Induced Fever Therapy - William Coley and Coley's Toxins
The history of bacteria induced fever therapy (fever induction therapy) began in the mid-19th century by several European physicians. One of the first papers on hyperthermia was published in 1866 by a German surgeon Carl D. W. Busch. He described the case of a 43-year-old woman with advanced sarcoma on her face. After the tumor was removed, the patient fell ill with erysipelas. The disease induced high temperature which led to tumor regression for over two years. Busch's discovery was fundamental because it was the first reported case showing that high temperature can selectively kill cancerous cells while not affecting normal cells.9 Along that time others reported that cancer patients who experienced a feverish period after surgery survived significantly longer than patients without fever. In 1882, Fehleisen discovered the erysipelas causative organism as Streptococcus pyogenes. He inoculated these live bacteria to seven cancer patients and achieved complete remission in 3 cases.10 In the second half of the 19th century, the practice of infectious febrile therapy was quite common not only in Germany and France, but also in Russia, and it was used to treat a wide range of diseases.
The American surgeon William Coley (1862-1936) also observed that cancer patients often recovered from their cancer if they had suffered a severe post-surgical infection of the wound accompanied by high fever. Coley developed the theory that it was the fever from the infection which had helped patients to recover from their cancer. So, he began to treat patients by injecting a Streptococcus pyogenes directly into inoperable tumors. He found the treatment was most effective when it provoked a fever and a full-blown infection. This led physicians to understand that the increase in body temperature not only mobilized the body's own immune system, thus fighting off the infection, but also destroyed the tumor at the same time.
Later Dr. Coley decided to use a mixture of dead Streptococcus pyogenes and dead Serratia marcescens bacteria. This was subsequently termed "Coley's Toxin". In 1893, the first patient to receive Coley's Toxin was John Ficken, a sixteen-year-old boy with a massive abdominal tumor. Every few days, Coley injected this bacterium directly into the tumor mass and produced the symptoms of an infectious disease, but did not produce the disease itself. On each injection, there was a dramatic rise in body temperature and chills. The tumor gradually diminished in size, and after four months of intensive treatment, the tumor was a fifth its original size. Later that year the remains of the growth were barely perceptible.11 The boy received no further anticancer treatment and remained in good health until he died of a heart attack 26 years later.
Over the next 40 years, as head of the Bone Tumor Service at Memorial Hospital in New York, Coley injected more than 1000 cancer patients with bacteria or bacterial products. By the end of his career, Coley had written over 150 papers on this subject.12, 13, 14 Coley mainly used his toxins on patients with inoperable bone and soft-tissue sarcomas, observing that this treatment was less effective on other types of cancer such as melanomas and carcinomas. Beginning in 1899, Parke Davis and Company had begun to prepare the Coley's Toxins, so they were available for all physicians. They were widely used for the next 30 years.
In the first half of the 20th century, different formulas of Coley's Toxins were manufactured by several drug companies in the U.S. These formulations were used to treat patients with a variety of types of cancer until the early 1950s, when other forms of cancer treatment became more widely used, such as radiotherapy. Despite his reported positive results, Coley's Toxin came under a great deal of criticism because many doctors did not believe it possible. Medicine has always been, and still is, ruled by belief.
Additional controversies surrounding Coley's work reflect the field of oncology struggling to stabilize its understanding of how to treat cancer. For example, James Ewing, perhaps the most famous cancer pathologist in the country, was a leading opponent of Coley's work. This was a problem for Coley because Ewing was Medical Director of Memorial Hospital, and for many years was Coley's boss. Their memos to one another reflect constant interpersonal animosity. Ewing himself had become a fanatical supporter of radiation therapy for the treatment of all bone tumors and repudiated any other theories for the treatment of cancer. Ewing therefore refused Coley permission to use his toxins at Memorial Hospital. This was ironic, because Coley had more experience than any other surgeon in the country in treating the small round blue cell sarcoma that still carries Ewing's name.
Skepticism and criticism, along with the development of radiation therapy and chemotherapy, caused Coley's Toxin to gradually disappear from use in the U.S. By 1952, the Park Davis Company no longer produced Coley's Toxin, and, in 1962 the FDA refused to acknowledge Coley's Toxin as a proven drug.15 Thus, in 1962 it became illegal to use Coley's Toxin for the treatment of cancer in the United States. However, in Europe, Australia and Asia, bacteria induced hyperthermia continued in certain medical circles, and has become an advanced immunotherapy. In retrospect, William Coley's intuitions were correct. Using fever induction therapy to stimulate the immune system is effective in treating cancer. Coley was a model of the clinician-scientist, treating patients and using his practice to initiate research and build theories. But he was a man before his time, and he met with severe criticism.
During the second half of the 20th century, which is characterized by heavy use of antibiotics, fever was regarded by mainstream medicine as an unnecessary, weakening state which should be suppressed or prevented. The situation today has not changed much. The immune system is constantly repressed with anti-microbials and even mild fever is suppressed with anti-febriles.
The Modern Development of Hyperthermia
Fever induction therapy today involves the injection of specific bacterial lysates, which induce the release of cytokines, and bring about a fever reaction. The immunological response of cytokine release with underlying fever has been extensively researched over the last several decades. Direct endogenous pyrogens, or proteins that produce fever, are associated with IL-1alpha, IL-1beta, TNF-alpha, TNF-beta (lymphotoxin-alpha), IL-6, macrophage inflammatory protein 1, and IFN-alpha.16, 17, 18 Indirect fever inducers are considered to be IL-2 and IFN-gamma.19 Most fever response usually only reaches a maximum of around 39°C (102°F), which is not sufficient to induce enough thermal damage within cancerous tissue. However, the immunological effect of this treatment can greatly improve the general condition of the patient through stimulating the immunity, resulting in a positive response.20, 21
Within the last century, hyperthermia has been shown to be of great use in treating cancer. Such techniques as immersion in heated water, artificial fever production by toxins, and fever cabinets have been used historically. In September 1965, the physicist and cancer researcher Manfred von Ardenne (1907-1997) presented in the Heidelberg Cancer Research Centre the concept of his so-called systemic Cancer Multistep Therapy - a combined modality treatment including whole-body hyperthermia. At the time, whole-body hyperthermia was attained by a warm water bath plus induced hyperglycemia and a high dosage application of oxygen. Since hyperthermia treatment was a very strenuous procedure, Ardenne supplied oxygen to the patients in support of the treatment. At first he had difficulty optimizing the treatment, since there was no way to exactly control the internal temperature of the body.22 Dr. von Ardenne was the first person to specifically treat cancer patients with the help of hyperthermia by using long-wave infrared light. Over the years, however, more technologically advanced equipment guaranteed better control of the overheating process and made widespread use of hyperthermia in clinics possible.
Types of External Hyperthermia
To reach the temperatures necessary to disrupt cancer cell growth, today externally induced hyperthermia procedures are used. These involve ultrasound, microwave, radio wave technology, or by infrared light. This differs from induced fever therapy, by which body temperature increase is induced with a bacterial protein. The high-tech science of external hyperthermia has greatly evolved in the precise control of the therapeutic application of heat. Numerous devices have now been developed to produce elevated temperatures of the body, by a variety of physical means. After a shift in focus to local and regional hyperthermia, there is now a resurgence of interest in systemic hyperthermia or whole-body hyperthermia (WBHT) for treatment of cancer as well as other systemic diseases.
Apart from the induction of biological fever by pathogens or toxins, all methods of external hyperthermia involve transfer of heat into the body from an external energy source. The administration of a hyperthermia treatment requires technology to heat the tissues as well as technology to monitor, control and evaluate the thermal or other parameters involved in the heat treatment. External hyperthermia is basically divided into three types: local hyperthermia, regional hyperthermia and whole-body hyperthermia.23, 24 Because of the different routes and different range of heating temperature, the treatment scopes are also different. Local hyperthermia is appropriate for small tumors, such as breast, whereas, the regional and whole-body variant is used for metastatic tumors.
Local hyperthermia is performed with superficial applicators (microwave, radio wave, ultrasound) of different kinds (waveguide, spiral, current sheet etc.). These applicators are positioned upon superficial tumors coupled to the tissue by water bags or a water bolus. The penetration depth depends on the frequency and size of the applicator, and typically the clinical range is not more than 3 – 4 cm. A system for local hyperthermia consists of a generator, the control computer, the applicator and the possibility to measure temperature in the tumor. Then the power is increased until the desired temperature is achieved. Indications for local hyperthermia include chest wall recurrences, superficial malignant melanoma lesions, lymph node metastases of head and neck tumors.
Local hyperthermia is further typed as External, Endoluminal, and Interstitial. Local external approaches are used to treat tumors that are in or just below the skin. External applicators are positioned around or near the appropriate region, and energy is focused on the tumor to raise its temperature. Intraluminal or endocavitary methods may be used to treat tumors within or near body cavities, such as the esophagus or rectum. Probes are placed inside the cavity and inserted into the tumor to deliver energy and heat the area directly. Based on their design the interstitial hyperthermia techniques can be categorized in four groups; radiofrequency, microwave, hot source and ultrasound techniques. The hot source techniques distinguish themselves from the other techniques because the tissue is heated by thermal conduction while the other techniques deposit energy directly in the tissue at a distance from the heating source.
Endoluminal hyperthermia uses natural orifices to position various kinds of endocavitary applicators (microwave, radio wave, ultrasound) in direct contact to a tumor. A counter electrode might be positioned on the body surface to steer the power deposition pattern. By physical reasons, the penetration depth around those endoluminal applicators is limited and of the order of the applicator´s diameter (in the cm-range). Accessible tumors include esophageal carcinoma, prostate carcinoma, rectal and cervical carcinoma.
Interstitial techniques are used to treat tumors deep within the body, such as brain tumors. This technique allows the tumor to be heated to higher temperatures than external techniques. Under anesthesia, probes or needles are inserted into the tumor. Imaging techniques, such as ultrasound or magnetic resonance, may be used to make sure the probe is properly positioned within the tumor. The heat source is then inserted into the probe. For interstitial hyperthermia, an array of interstitial antennas (microwave) or electrodes (radio wave) is implanted in accessible tumors which might be located in deep or superficial tissues. The distance between the antennas must not exceed 1 – 2 cm, and therefore lesions with diameters below 5 cm are suitable (in order to limit the number of puncturing tracks). Interstitial hyperthermia is an invasive procedure. Temperature measurements must be performed at the antennas and between them. In most systems, every single antenna is controlled by its own generator. Dedicated systems have in addition two or more segments per antenna or electrode controlled in phase and/or amplitude. Clinically interstitial hyperthermia has been applied for prostate carcinoma, recurrent breast cancer and malignant brain tumors.
Thermoablation may also be performed with thin laser applicators (laser induced thermotherapy or LITT) and is considered a minimally invasive procedure. The applicators must be implanted in the lesions under computer tomography or magnetic resonance guidance. Achieved temperatures are high (up to 90 °C), but the thermal gradients are quite steep and the effective range is 1 – 2 cm (i.e. lesions with diameters of 3 – 4 cm are the limit using standard techniques). Liver metastases (number up to 4) are probably the most treated condition with LITT.
Another form of local hyperthermia that is growing in popularity, especially in China, is high intensity focused ultrasound (HIFU). HIFU is a hyperthermia procedure that applies precise high-intensity focused ultrasound energy to heat to destroy cancerous and diseased tissue through ablation. When magnetic resonance imaging is used for guidance, the technique is sometimes called magnetic resonance-guided focused ultrasound, often shortened to MRgFUS or MRgHIFU. Magnetic resonance imaging guidance allows the tumor to be visualized and targeted, and in addition provides a means to measure tissue temperatures in real time. HIFU is used often as a solo treatment or sometime used with other treatments. Unlike radiotherapy, HIFU is a non-invasive technique that also leaves healthy tissue next to a tumor undamaged. In China, over the last decade, thousands of patients with breast cancer, liver cancer, pancreatic cancer, bone tumors, renal cancer, prostate cancer and uterine fibroids have been treated with ultrasound imaging-guided HIFU.
In the U.S., HIFU is only approved treat uterine fibroids. However, there is ongoing research in the area of breast cancer with HIFU conducted by Dennis L. Parker, PhD, a professor of Radiology at the University of Utah and Director of the Utah Center for Advanced Imaging Research (UCAIR). Dr. Parker and colleagues at UCAIR are leading in the development of a HIFU system for breast tumors. Now in prototype form, their system has been tested on phantoms and samples. According to Dr. Parker, "From the standpoint of something that could ultimately be used to treat breast cancer, I think this is an excellent, potential device. The advantage of HIFU for breast cancer is that it's totally noninvasive. It has the opportunity eventually to totally eradicate the disease without any surgical intervention at all."25
In regional hyperthermia, interference patterns in deep seated tumors of the pelvis or lower extremities are generated by an array of phase-controlled antennas radiating in the range of 70 – 150 MHz These antennas are surrounding the whole circumference of the cross section, i.e. all possible directions are employed to deposit power into the target volume. The higher the number of antennas (and the higher the frequency), the better the potential to control the patterns. In particular, several rings of antennas in direction of the patient axis are useful to enable the flexibility with respect to the anatomical structures for optimization. A current frequency of clinical interest is 100 MHz. Locally advanced and/or recurrent tumors of the pelvis are the major indications for regional hyperthermia, i.e. rectal carcinoma, cervical carcinoma, bladder carcinoma, prostate carcinoma, or soft tissue sarcoma.
In contrast to local or regional hyperthermia which heats only one part of the body, namely where the tumor mass is located, whole body hyperthermia (WBHT) heats the entire body. WBHT heats the whole body either up to 42 °C for 60 - 120 minutes (so-called extreme WBHT), or only 39.5 – 41 °C for longer time, e.g. 3 hours (so-called moderate WBHT). Temperature and duration of treatment is usually individually determined depending on the patient's health condition. Between the heating and cooling phase, the entire procedure may last about 4 to 5 hours. Generally, WBHT in the treatment of metastatic cancer raise the patient's temperature to 41.6° C. to 41.8° C for 60 to 90 minutes. This is much higher temperature and longer plateau than the WBHT IRB26 research protocols used in the U.S.
For WBHT, the patient is as far as possible thermally isolated, and infra-red radiation with different ranges of wavelengths (for several available systems) is depositing energy in the superficial tissues of the body until the desired temperature is achieved. For extreme WBHT, 60 – 120 minutes are needed until the patient has 42 °C achieved under general anesthesia (plus/minus intubation). For moderate WBHT, often deep sedation is sufficient. In any case, careful monitoring of the systemic parameters are required for any kind of WBHT and an intensive care unit should be available in the background.
WBHT is used principally in advanced stages of cancer and as a metastatic prophylaxis in high risk patients, e.g., young premenopausal women with breast cancer, lymph node involvement and negative hormone receptor status. Up to now, several WBHT-approaches have proved to be safe and associated with acceptable toxicity rates when radiant heat devices are employed. Until the late 1990s, the use of WBHT was restricted to a few specialized treatment centers worldwide. During the last 20 years, a larger number of WBHT-devices have been put into operation throughout Europe and Asia. Because many women diagnosed with invasive breast cancer have undetected occult metastases at the time of their primary tumor diagnosis it may be more desirable to employ WBHT as opposed to local hyperthermia.
In Europe and Asia there are several types of WBHT systems in clinical use. Over the last decade, patient warming with infrared radiation has been established as a standard procedure for WBHT treatment. WBHT systems differ with regard to the spectrum of infrared radiation used and the area of application (front or back of the patient). At the time of this writing some of the more common systems are the Heckel HT-300027, the Oncotherm WBH-200028, the Chinese manufactured Gamma Star GMX-RL-03 WBH system, and the Ballya International Ltd WBH system, only to name a few. The Heckel HT-3000 (Manufactured by: Hydrosun Medizintechnik GmbH, Esslingen, Germany), uses water-filtered infrared radiation (wIRA) delivered by four wIRA emitters to the chest, and two heating elements for warming the air under the tent-like canopy. It features continuous measurement of core temperature, heart rate, oxygen saturation, blood pressure, ECG, respiratory frequency. The OncoTherm WBH-2000 unit is a chamber that encloses all but the patient s head. Special light-emitting diode (LED) radiators deliver computer-generated, alloyfiltered IRA wave-lengths that penetrate the skin to deliver heat to the capillary bed. The manufacturer claims that these wave-lengths also preferentially stimulate the immune system.
Hyperthermia Societies
Much of the history and development of hyperthermia is rooted in Europe, and has been fostered by organizations such as the European Society for Hyperthermia Oncology.29 China and Japan have also become world leaders in the clinical use of hyperthermia. In 1978, research on hyperthermia in Japan was started by the Hyperthermia Study Group. Six years later, the Japanese Society of Hyperthermic Oncology (JSHO) was established. Since then hundreds of research articles have been published in China and Japan. It is estimated that more than two hundred hyperthermia units are in use across Japan. Compared to other countries, Japan has the highest number of hyperthermia equipment installed, and the most doctors involved in hyperthermia therapy. The main reasons for the advanced state of hyperthermia research in Japan include the development of excellent heating equipment, high membership in JSHO, grant-in-aid by the Japanese government, and coverage by insurance for this form of therapy.30
In 1981, the North American Hyperthermia Society was founded by those who shared the opinion that hyperthermia continued to show promise as a therapeutic modality, and that the growing numbers of investigators and the amount of data produced required a separate forum for discussion of results and planning future directions of research and application. In 1985 the North American Hyperthermia Society, together with the European Society for Hyperthermic Oncology, and the Japanese Society of Hyperthermic Oncology cooperatively founded the International Journal of Hyperthermia and adopted it as their official journal.31
Despite several decades of ongoing usage in Europe, China and Japan, and numerous human studies, WBHT is still considered 'experimental' in the U.S. where chemical medicine trumps all other forms of oncological therapy. Hence, WBHT is limited to a few research IRBs (institutional review board) in the U.S. However, numerous clinics abroad, especially in Germany, Austria, Italy, Switzerland, China and Japan, regularly use WBHT as an integrative approach for cancer care.
Hyperthermia Anticancerous Mechanisms
Understanding of the mechanisms by which heat destroys cancer cells is ever changing. Partly because is a new emerging field, and the biological effects of local hyperthermia and WBHT, or systemic hyperthermia, are different. Aside from the stimulation to the immune system, hyperthermia has a unique physiological effect on tumors. It was initially thought that tumor cells have intrinsically higher heat sensitivity than normal cells, but this is now shown to be not universally true. Although some neoplastic cells are more sensitive to heat than normal cells, this appears to be more the case for local hyperthermia than the lower temperatures used in WBHT. However, as we have seen in oxidative therapy, tumors do have their weaknesses, and heat definitely can disrupt the tumorous environment. Contrary to healthy tissue, tumors cannot easily divert heat because of their primitive blood supply. This has to do with the fact that tumor cells have a different metabolism and their vascular supply network is different compared to those of healthy cells. Because of their poorly constructed vasculature, tumors have poor perfusion, thus heat dissipation by convection is reduced. At high temperatures (43.8 C and up) tumors become a heat reservoir with a consequent rise in temperature, which if maintained for too long damages their microcirculation and further impairs convective heat loss. Also increased fibrinogen deposition at damaged sites in the vascular wall leads to occlusion of tumor microvessels. Significant heating of the tumor cells results, which may be directly cytotoxic.32
We know when body temperature reaches 101.3° F (38.5° C) the immune system becomes active and begins producing white cells and immune chemicals. Within hours, almost every major defense within the immune system doubles its efforts. This process appears to be dormant in many cancer patients, who typically report never having experienced a fever in a long time. Results from studies show that cancer cells form a special type of protein structure on their surface when heated to a temperature of approximately 42° C, which does not happen with normal cells. These protein structures, also known as heat shock proteins (HSPs), are recognized by the body's immune system as foreign substances, thus enabling the immune system to destroy them.33, 34
The increased expression of HSPs after hyperthermia treatment has been shown to correlate with increased immunogenicity of cancer cells through their lysis by alpha/beta T cells. HSPs belong to a group of "stress proteins" secreted after a wide range of stimuli such as exogenous heat, oxidative injury, heavy metal toxicity, and microorganism toxins. HSPs have been suggested to act as 'molecular chaperones' in presenting protein structures to the lymphatic system. In this respect they may serve as carriers for antigenic tumor peptides, and thereby, increase the natural immunity to attack cancer.35, 36
Basically, hyperthermia works in two ways: first by creating thermal damage and secondly by stimulating the body's own immune system.37 An overview of some specific mechanisms of hyperthermia in cancer treatment are as follows.38
1. Programed cell death of cancer cells (apoptosis) - The mechanisms of hyperthermia causing cancer cell apoptosis are complex, but mostly related to disrupting the vascularity of the tumor, denaturing cellular proteins, changing the fluidity of bio-membrane, leading to destruction of the cancer cell membrane, as well as cell nuclei and other cytoplasmic components.
2. Inhibiting metastasis - Hyperthermia can inhibit the synthesis and repair of cell DNA, RNA and protein to stop cancer cells' reproduction, and inhibit the gene expression and synthesis of tumor matrix metalloproteinase to inhibit the metastasis trend of tumor. Another proposed metastasis inhibiting mechanism of hyperthermia is that it can inhibit transforming growth factor beta-1-induced epithelial-mesenchymal transition in cancer cells, hence, altering the properties of metastatic potential in cancer cells and inhibit tumor metastasis.39
3. Inhibiting the formation of tumor blood vessels (anti-angeogenesis) - Studies have shown the WBHT can inhibit gene expression and synthesis of vascular endothelial growth factor excreted by cancer cells. This can prevent the formation of blood vessels to tumors, which destroys the basic condition for growth and development of cancer metastasis.
4. Enhancing the effect of chemotherapy - WBHT results in an increase delivery of drugs to tumor sites partly because of increased systemic blood flow. Additionally, because hyperthermia can change the permeability of cell membranes this can increases the concentration of anticancer drugs in the cancer cell cytoplasm.40 WBHT can also increase blood vessel permeability by increasing the effective pore size between the loosely bound endothelial cells forming tumor microvessels, permitting larger molecules, such as nanoparticles and gene therapy vectors, to pass into the interstitium.41
5. Enhancing the effect of radiotherapy – Hypoxic cells and the cells in the S-stage are especially sensitive to heat, but resistant to radiation. Hence, hyperthermia and radiotherapy compensate each other. Hyperthermia has been shown to potentiate the effect of radiation therapy in the treatment of superficial lesions (less than 3 cm in depth).42 Clinical experience has largely been limited to treatment of recurrent, metastatic superficial melanomas, chest wall recurrence of breast cancer and cervical lymph node metastases from head and neck cancers. Tumor depth is a critical factor when combining radiation therapy and hyperthermia. Lesions less than 3 cm from the surface treated with radiation therapy and hyperthermia have been shown to have a significantly greater complete response rate compared to the complete response rate of lesions greater than 3 cm deep.
6. Bone marrow protection - WBHT can stimulate bone marrow by increasing peripheral blood flow and can induce the differentiation of peripheral blood and hematopoietic stem cells in bone marrow. Clinical practices showed that whole-body hyperthermia will not increase marrow suppression like radiation or chemotherapy.
7. Hyperthermia improves the function of immune system - Because practically all cancer patients have a lower than average core temperature and are unable to develop a fever they are unable to activate their immune system. Hyperthermia assist in activating several immune functions. Though the immunotherapeutic role of hyperthermia is not yet completely understood it has been shown that WBHT can activate long acting T-lymphocyte and increase the activity of T- and B-lymphocyte.43 At treatment temperatures above 40°C, both enhancing and inhibitory effects of cytotoxic activity of NK cells against tumor cells have been reported. In particular, an enhancement of human NK cytotoxicity against tumor cell targets has been demonstrated using a temperature of 39.5 °C.44 WBHT can also facilitate the redistribution of body's white blood cells to improve the monitoring function of body's immune system.
Though whole-body hyperthermia has primarily been used in the field of oncology, it is also used to treat an array of other illnesses. Particularly, WBHT is clinically used for certain chronic infections diseases, such as HIV45, hepatitis C46, herpes47, borellia48 (Lyme disease) and numerous other pathogens.49 Literature supports that the retrovirus, human immunodeficiency virus (HIV), which is thought to cause acquired immunodeficiency syndrome (AIDS), is heat sensitive at temperatures which can be tolerated in humans. This heat sensitivity is true for many viruses and bacteria.
Toxicity and Side-Effects
Based on several research groups' reports, whole body hyperthermia, accompanied by suitable monitoring, does not lead to any serious or sustained organ dysfunction and can therefore be regarded as a safe therapy.50, 51, 52, 53, 54 Bear in mind that many advanced cancer patients are debilitated, anemic, and may have poor organ function due to chemotherapy and radiotherapy. Sophisticated monitoring equipment has greatly lessened the side-effects of WBHT, but the condition of the health patient should be evaluated prior to each treatment.
Since WBHT is rarely utilized as a single treatment modality, it is important to recognize that systemic hyperthermia combined with chemotherapy and radiation and chemotherapy may enhance some of the toxicities associated with these modalities. For example, the cardiotoxicity of doxorubicin and both the renal toxicity and hematological toxicity of platinum agents may increase under hyperthermia.55 However, non-toxic biological regulatory therapies are excellent companions to hyperthermia and minimize any risk.
Impressive effects of hyperthermia, both internally induced as fever therapy, and external applications, have been proven again and again in scientific studies. Research has shown that temperatures between 40°C and 43°C can activate immunity, damage cancer cells, and treat numerous infectious diseases with no or minimal injury to normal tissues. There currently are dozens of clinics in operation throughout the world that are using various types of hyperthermia for treatment in oncological and other conditions.
1. van der Zee J. Heating the patient: a promising approach? Annals of Oncology 2002; 13(8):1173–1184.
2. Cavaliere, R., B. C. Giogatto, and B. C. Giovanella. "Selective heat sensitivity of cancer cells." Cancer 20.9 (1967): 1351-1381.
3. Pettigrew, R. T., et al. "Clinical effects of whole-body hyperthermia in advanced malignancy." Br Med J 4.5946 (1974): 679-682.
4. Overgaard, Kristian, and Jens Overgaard. "Investigations on the possibility of a thermic tumour therapy—I.: Short-wave treatment of a transplanted isologous mouse mammary carcinoma." European Journal of Cancer (1965) 8.1 (1972): 65IN369-68IN878.
5. Vermel, E. M., and L. B. Kuznetsova. "Hyperthermia in the treatment of malignant diseases." Voprosy onkologii 16.2 (1970): 9
6. Hildebrandt B, Wust P, Ahlers O, et al. The cellular and molecular basis of hyperthermia. Critical Reviews in Oncology/Hematology 2002; 43(1):33–56.
7. Wust P, Hildebrandt B, Sreenivasa G, et al. Hyperthermia in combined treatment of cancer. The Lancet Oncology 2002; 3(8):487–497.
8. Breasted.. J. H.. 1930. The Edwin Smith Surgical papyrus. Chicago.
9. Busch, W. "Über den Einfluss Welch heftigere Erysipeln auf organisiente Neubildungen aususuben." Verhandl naturn Preuss Rein Westphal 23 (1866): 28.
10. Fehleisen, Friedrich. "Über die Züchtung der Erysipelkokken auf künstlichem Nährboden und ihre Übertragbarkeit auf den Menschen." Dtsch Med Wochenschr 8 (1882): 553-554.
11. Coley WB. The treatment of malignant tumors by repeated inoculations of erysipe

redpajama_set_name: RedPajamaCommonCrawl


When you print your postcards on recycled 13-point matte cover stock, you can rest assured that you're printing an eco-friendly product without sacrificing the quality and promotional power of your printed piece. A matte finish brings out deep, rich colors with elegance and impact; while the recycled properties means you're working to save the environment without breaking the bank.
Coupled with recycled paper, soy inks are probably the easiest change you can make; and just like recycled paper, soy inks do not sacrifice quality. In fact, soy inks are capable of faithfully reproducing bright, vivid colors that traditional petroleum inks can't match. So what's the difference? Soy inks emit far fewer volatile organic compounds during the drying process than petroleum-based inks, so they're much more environmentally friendly.
If you use a perforated coupon, ticket or response card on your postcards, make sure you recycle them once you've collected the data you need. Recycling doesn't just make sense from an eco-friendly level, but it also makes sense from an investment standpoint since many municipalities will haul recyclables away for free, but charge for garbage pick-up services. Perhaps your old postcard stubs will end up as part of your next postcard mailing campaign.
Simultaneously promote your company's green agenda and add value to your postcards by including a perforated list of ways your customers can go green at home or in the office. You can also use this space to tell the story of your company's green business practices and the positive influence these practices have on the environment. Localize this as much as you can so you can better connect with your customers.
It is always advisable to get a hardcopy postcard proof so you can double-check spelling and other typos, postcard design layout position and color matches in person; but if you are just changing some text or have worked with your printer on a very similar postcard before, you can get away with an electronic proof. Electronic proofs save time and money, and are eco-friendly because they also save on paper, postage, packaging and delivery emissions. As you can see, going green with postcards is simple when you know the right steps to take. Best of all, green postcards look just as great as - if not better than - their traditional non-green counterparts. Go green with postcards and boost business, save the environment, and make more money today!


text:
HomeAsiaJapan Literature
Japan Literature
By searchforpublicschools September 23, 2021 Asia 0 Comments
Only what was perpetuated by the oral tradition and later entrusted to writing has been handed down from the original production. This is the case of the norito (spoken words), a sort of solemn speeches of a religious and magical-enchanting nature, linked to the formation of the Shinto religion and of the Japanese nation. The introduction of Buddhism and Chinese culture in general was followed by radical innovations in the socio-political structure of the country and its culture. To Taishi Shōtoku (573-621), the greatest statesman and scholar of ancient Japan, we owe the Code in seventeen articles, the first body of written laws based predominantly on Confucian thought. Shōtoku was also the propagator of Buddhism and the first commentator of the holy scriptures (sūtra). Starting from the first certain documents of the Nara era, Japanese literature is usually divided into the six great periods through which the history of the country took place: Nara, Heian, Kamakura, Muromachi and Momoyama, Edo (or Tokugawa), modern and contemporary.
THE NARA PERIOD
In the Nara period (645-794), from the name of the first imperial residence, historiography was the greatest achievement. In 712 the Kojiki (Memoirs of Ancient Events) was compiled, in 720 the Nihongi (Annals of Japan). Written on Chinese historiographic models, they collect all the mythological and legendary heritage and outline the divine descent of the imperial dynasty, of which the first centuries of history are narrated. Of the sec. VIII are the fudoki, topographical reports that illustrated the characteristics of the individual areas of the country. The only one preserved in its entirety is the Izumo Fudoki. The largest and oldest repertoire of poems in the Japanese language is the Man'yōshū (Collection of ten thousand leaves). The compiler is uncertain, but perhaps more rewriters have made successive extensions to a lost original edition. Among the 561 poets, mainly of the tanka genre, the so-called "big five" of Man'yōshū emerge : Hitomaro, Akahito, Okura, Tabito, Yakamochi. The work is considered the most precious page of Japanese lyric.
THE HEIAN PERIOD
The Heian period (794-1185), named after the new capital, Heian-kyō (later Kyōto), was characterized by a refined culture imbued with Chinese taste. In the sec. X was ordered the Kokinshū (Collection of ancient and modern poems), of which the preface by Tsurayuki Ki no (872-ca. 950) is famous, which traces a brief history of Japanese poetry. The first diary of this first critic is also the Tosa Nikki (Tosa's diary), a genre always widely cultivated, in which the three greatest writers of the time excelled: Shikibu Izumi (ca. 966-1030), Shōnagon Sei (b.966 c.), Shikibu Murasaki (978-ca. 1015). The latter, however, is much more famous for the work that is considered one of the masterpieces of world literature: the Genji Monogatari. It constitutes the most mature literary expression of the narrative genre called monogatari of which the anonymous fairy tale, Taketori Monogatari (The Tale of the Bamboo Cutter), constitutes the first surviving example. Another famous poet, Emon Akazome no (976-1041), is credited with the Eiga Monogatari (Story of splendors), which is the first example of historical monogatari. The body of the Shi Kagami is also historical (Four mirrors), which introduce the historical fact as a topic of dialogue between several people. Visit rrrjewelry.com for mountaineering in Asia.
THE KAMAKURA PERIOD
With the Kamakura period (1185-1333), named after the city seat of the first military government or shogunate, court historiography lost prestige in favor of the shogunal one. The Azuma Kagami (Mirrors of the Eastern Provinces) traces the history of the country from 1180 to 1266. In fiction there was the development of the gunki monogatari (war story), of an epic tone, inspired by the recent struggles between the great feudal families. Famous: the Hōgen Monogatari (History of the Hōgen era), the Heiji Monogatari (History of the Heiji era), the Heike Monogatari (History of the Heike) and the Genpei Seisuiki (Prosperity and decay of the Taira and Minamoto). More late the Taiheiki (Chronicle of the great peace), which narrates the fall of the Kamakura shogunate and the establishment of that of the Ashikaga. Two works of the zuihitsu genre (scattered notes) are famous: the Hōjōki (Memories of my hut) by Chōmei Kamo no (1154-1216) and the Tsurezuregusa (Variety of idle moments) by Hōshi Kenkō (1283-1350). A nice travel diary is the Izayoi Nikki (Diary of the sixteenth night) of the nun Abutsu-ni (1209-1283). Another long diary is the Meigetsuki (Notes written in the moonlight) by Teika Fujiwara (1162-1241), one of the compilers of the Shinkokinshū and other official anthologies, but above all famous for a lucky choice of tanka of the sec. VI-XIII, the Hyakunin Isshu (One hundred poems of one hundred poets).
THE MUROMACHI AND MOMOYAMA PERIODS
During the Muromachi and Momoyama periods (1392-1603), from the establishment of the Ashikaga shogunate after long struggles (which included the short period of Nanboku-chō, 1333-92), Kyōto was restored as an effective capital. A new poetic form, the renga (chain poetry), was born from the artifice of poetic tournaments and fashion composition games at court. Famous author of renga was Sōgi Iio (1421-1502), who dictated the principles of composition in Azuma Mondō. His disciple was Botanka Shōhaku (1443-1527). Later the initial part of the renga broke off in a tiny three-line poem of mostly humorous content, called haiku and widely cultivated in the following centuries. But the great achievement of the period was the noh theater.
Tags:Japan
Important Information about United Arab Emirates
Education in Indonesia
Education in Yemen


Most people who read picture books to children enjoy the simple language and uncomplicated story lines. It's 'cute.' It's 'simple.' So writing them must be easy, right? You probably don't want to say that to someone who writes picture books!
Advice that published authors, editors and agents give to struggling picture book writers is invaluable.
'Use the five senses' to bring the reader into the story.
Use dialogue and action to move the story along.
But how exactly do we do that? One way to learn is by reading other picture books. From the classics to those recently published and award-winning picture books! Read them all! But especially read recently published picture books. Within their pages you'll see how other authors successfully make use of different writing techniques.
When you read picture books, read them out loud.
When asked what the editing process is like for her when working on a picture book she said, "Reading it aloud over and over." Click the link above to read the entire interview.
Read many picture books to hone your ear for sentence structure, vocabulary, pacing, rhythm, and page turns. Listen for language. The language needs to sound good when read aloud.
Harold Underdown's website, The Purple Crayon, has links to articles about writing picture books.
Read a post by Emma Dryden about Why Playing It Safe May Be the Most Dangerous Game of All.
Read Christie Wright Wild's blogpost for another perspective on how to study picture books.
Why Do Editors Say Not to Write in Rhyme? Read Tara Lazar's blog post for some of the reasons.
Picture books aren't just for kids! Great post, Peggy!


The controversy over GEJ's decision to rename UNLAG after MKO Abiola will continue to rage on years after the deed was done.
I have never really liked Jonathan, I also campaigned against him and did not vote for him. I make no apologies for this because I am convinced he does not have the capacity to put Nigeria in the right course. However let us try to objectively analyse the issue at hand.
Now there is nothing wrong in renaming an institution to immortalise MKO Abiola, as a matter of fact it is a worthy act.
Abiola deserves to be honoured by the Federal Government and much more. It is even long overdue for Abiola till date remains a colossus. He was the most successful businessman of his time and the biggest philanthropist ever to come out of Africa. He donated freely to universities and built hostels, libraries and schools in different parts of the nation. He was indeed a good example of a detribalised Nigerian. In what remains our freest and fairest election till date, he won a landslide victory cutting across various ethnicities even though he contested on a muslim/muslim ticket. He was courageous enough to defend his mandate even against the intimidating enemies of democracy and for this reason he paid the ultimate price and so also did his wife. What more can one ask of a hero?
Let us recall that many Nigerians especially those from the southwest have been calling for Abiola to be immortalised. In fact ACN controlled states actually celebrate June 12th rather than May 29th as democracy day. So one is petrified at the amount of negative reactions this supposedly worthy act is generating across the nation bringing us to the question why all the criticisms. Why is this particular gesture receiving more knocks than kudos.
Firstly if majority of us agree that Abiola is our beacon of democracy then I think it will be right to say that no institution governmental or educational is too big to be named after him. It will therefore be right to say that UNILAG should consider itself lucky to bear the name of our national hero of democracy as institutions of equal stature such as ABU formerly University of Northern Nigeria and OAU formerly University of Ife were both renamed after what one can rightly describe as regional heroes. Those who argue that it is unimaginable for America to rename institutions like Havard etc to me are completely ignorant as the school initially called new college was renamed after John Havard after he donated his library to the school. John Havard himself was English!
There is no doubt that the decision to change the name of the University of Lagos was not GEJ's sole decision, it would have been taken after deliberation by the Federal Executive Council. It is equally indisputable that the federal govt which wholly owns and funds the institution can decide to change the name as it pleases. Yet again there is no proof that govt did not consult the authorities of UNILAG before taking its decision as there is no statement emanating from the school authorities stating so, rather what we hear is that students are protesting. Granted that as stake holders it is their basic right to protest if not for anything but to let govt think thoroughly before making such decisions in future, but definitely not to consult them before taking executive decisions such as this. Pray how does a name change affect the standard of education in the school? Someone should tell these students to go and read the constitution!
Those who posit that naming a national monument in Abuja would have been better or making June 12th our democracy day appear to be the most practical here. However bearing in mind that OBJ, a south westerner blatantly refused to name as little as an alley after Abiola it becomes more commendable that GEJ was courageous enough to do so albeit inadequately. So to this school of thought I will say "half bread is better than none" because we have come to expect none from this lame administration. Maybe next year he may summon more courage to name something in Abuja and then go on to make June 12th our democracy day before we finally send him back to Otuoke in 2015. And to those who condemn this move as a cheap political gambit to woo the south west, well all I have to tell Jona is "guy you failed woefully" the Yorubas remain the foremost elites in our country, and cajoling them will obviously take more than this so maybe you should try other ways such as telling Aunty Peshe to move with Keke Napep on her next visit to Lagos so as to save Lagosians the pains of the gridlock suffered on her last visit.
Finally this should go a long way to show the president's handlers the declining popularity of this administration and maybe prevail on govt to abort its planned hike in electricity tariff tomorrow. It is not late to shelve that plan. Two protests against govt policies within 5 months is not a good sign. To be fore warned is to be fore armed!


My post on Cameron Diaz's street style (just below) had me hunting for her sweater and boots. I could not find the sweater and the boots are Frye, which we all know are a budget setback! I would love to own many pairs of Frye boots, but that has yet to happen, the funny thing is that JP owns a pair! Something is off in our household when he has some and I have managed to refrain, but he wears them well.
Anyway...here is my version since Cameron seems to be on a looser budget.
Crochet Pullover at Delia's for $45.
Please tell me which sweater you like better.
I think I would wear a long sleeve white t-shirt under either sweater, since it is below freezing in KC!
I think I like the pullover better than the cardigan.
It's crazy that KC has had more snow and colder days this year than Denver!
Stay warm my beautiful friend!


text:
Essence är folkmusikgruppen Väsens tredje album, utgivet 1993 av det franska skivbolaget Auvidis.

På skivan förekommer Väsens stora hitlåt "Josefins dopvals" som har genom åren blivit en av deras absolut populäraste låtar. Roger Tallroth skrev låten när hans systerdotter skulle döpas.

Låtlista

Total tid: 58:06

Alla låtar är arrangerade av Väsen.

Väsen
Olov Johansson — kromatisk nyckelharpa, kontrabasharpa
Mikael Marin — viola
Roger Tallroth — 12-strängad gitarr, 6-strängad akustisk gitarr, bosoki (3), mandola (21), viola (16)

Externa länkar
Väsens webbplats

Musikalbum 1993
Svenska folkmusikalbum
Album av Väsen

redpajama_set_name: RedPajamaWikipedia


Hatton Garden Jewellers is the online presence of Classic Jewels – a jewellery shop based in London. The company wanted its online store to have a different contact number to its retail shop, without the need to install a separate phone line within the same location.
Estelle Freedman, the managing director of Hatton Garden Jewellers, wanted a memorable number for its online store, which they could divert to their retail shop. She also wanted her staff to be able to determine which company (Hatton Garden Jewellers – the retail shop or Classic Jewels online) the caller was dialling, so that they could answer the phone appropriately and with the correct business name. Estelle also needed to be able to monitor the amount of calls that her online shop was receiving in comparison to her retail store enquiries, so she could differentiate between the two and regularly monitor where the majority of her business was originating from.
We were able to supply Hatton Garden Jewellers with a memorable 0845 number, combined with our Whisper service.
The Whisper enables companies to use multiple telephone numbers in its marketing campaigns, but receive all calls to the same, single location.
For staff to identify which company its customers were calling, even before answering the phone, Whisper announces the calls by a recorded message.
My Windsor, the online customer section of our website, allows customers to manage, edit and personalise their products. Basic call statistics are also available on My Windsor, which would enable Estelle to view the amount of calls that her 0845 number was attracting for Hatton Garden Jewellers.


text:
Forde upped as Tranter exits BBC Worldwide Prods
By Jesse Whittock
7th July 2015 @ 10:10
Matt Forde (below) has been promoted at BBC Worldwide North America after the company confirmed the departure of UK-bound Jane Tranter.
Julie Gardner is also leaving BBCWW North America's BBCWW Productions and subsidiary Adjacent Productions to work with Tranter (below right) on a new independent production company.
As a result of the departures, executive VP, TV sales and digital distribution Forde becomes EVP, content production, sales and distribution, reporting to BBCWW North America president Ann Sarnoff.
He will split his time between New York and LA and look to build the core development, production, distribution and sales segment of the six-year-old firm's business.
Tranter, who was head of BBC of BBCWW Productions and Adjacent, steps down on August 14. She has led the BBCWW unit since January 2009 after moving across from the UK, where she was controller of fiction.
She built BBCWW Productions up as a scripted and unscripted business, working on series such as the upcoming HBO miniseries Crime, History's remake of Top Gear, twelve seasons of ABC' Dancing with the Stars and three seasons of Starz's Da Vinci's Demons.
In 2011, she created Adjacent, which worked on format development of shows such as National Geographic Channel's Below Zero and Bravo's Ladies of In total she has overseen 870 of programming.
She worked closely with senior VP, scripted Gardner, who is best known for executive producing and relaunching Doctor Who with Russell T. Davies.
With their departures, the well-liked Forde steps up. He has been with the BBC's commercial arm since 1998 and joined the North America team six years ago. He worked on coproduction deals for shows including The Honourable Woman, Sherlock and Top of the Lake.
More recently he brought the BBC and PBS creative teams together on a three-year blue-chip factual coproduction agreement, and has also worked closely with on-demand platforms such as Netflix, Hulu and Amazon Prime Instant Video.
"Jane and the team have built a truly strong production business and I am very fortunate to inherit such a stellar team of creative and commercial executives – including Courtney Conte, who will work closely with me to ensure continued growth of this thriving business," said Forde.
"BBC is a fantastic brand and a powerhouse in creating IP and potential formats for the US market. With the media industry changing at speed, there is an ever increasing set of new opportunities to complement our growing slate of shows."
Tags: Adjacent Productions, Ann Sarnoff, BBC, BBC Worldwide, BBC Worldwide Productions, Below Zero, Crime, Da Vinci's Demons, Dancing with the Stars, Jane Tranter, Julie Gardner, Matt Forde, Sherlock, The Honourable Woman, Top Gear, Top of the Lake
Orders round-up: Crackle readies BIPOC interview series; ABC to remake 'Pooch Perfect'; Amazon seeks NHL 'All Or Nothing'
Crackle readies BIPOC interview series US streamer Crackle has ordered a new original series highlighting some of the world's greatest BIPOC artists, from actors and directors to producers, writers and musicians. Produced by Chicken Soup For The Soul Entertainment-owned Landmark Studio Group, the 10 x 60-minute Inside The Black Box was created by acting coach […]
Deals round-up: Globoplay adds eOne trio; CIA vs. Bin Laden doc sells; Dynamic TV goes 'Beneath The Surface'
Globoplay strikes eOne deal Brazilian streamer Globoplay has picked up a raft of shows from Entertainment One (eOne), including domestic first-run rights to Nurses, Burden Of Truth and Mary Kills People. The deal will see Globoplay take exclusive SVOD rights to the shows, which will debut this summer. It covers seasons one and two of Nurses, as […]
LA-based Principal Media hires Gary Rosenson & GRB alum Melanie Torres
LA-based distributor Principal Media has named industry veteran Gary Rosenson as its CEO, while former GRB Entertainment and A+E Networks exec Melanie Torres has been appointed to oversee global sales. Rosenson most recently founded and ran GR Media Advisors and before that was president of global television at Playboy Enterprises, focused on distribution and marketing […]
NENT Studios UK extends deal with Mexico's Dopamine for unscripted push
NENT Studios UK has expanded its partnership with Latin American firm Dopamine in a deal that will see the Mexican producer effectively co-commission programming alongside UK broadcasters and platforms. The agreement, which builds on an existing pact between the two companies struck last year, will cover the co-development of unscripted content for NENT Studios UK, which […]
BBC Scotland commissions Escobar assassination doc
Banijay, ITVS, All3, eOne & Fremantle unveil plans for The London TV Screenings
A+E Networks UK commissions crime trauma docuseries
UK distributor Passion launches 'producer programming brief'


text:
class Response(object):
    def __init__(self,state, plz, region, temp, wind, sun, rain):
        self.state = state
        self.plz = plz
        self.region = region
        self.temp = temp
        self.sun = sun
        self.wind = wind
        self.rain = rain

redpajama_set_name: RedPajamaGithub


4.75M Hindus & 2.25M Sikhs were persecuted in Pakistan during partition & those remaining, live in utter misery. A saga of atrocities & genocide as yet untold.
Maulvi Yaqoob estimates that around 9,000 conversions have taken place at the Madarsa during the last 15 years.
59 Hindus burned alive in Sabarmati train attack by Muslim mobs and 254 killed in subsequent riots.
Noakhali Massacre of 1946 – 5000 Hindus Killed, 3.5L Forced to Convert to Islam. Orchestrated by Muslim League, it was a planned, staged massacre of Hindus.
The Muslim riots of East Bengal in 1950 are one of the most blood curdling massacre of Hindus, where 5.6million Hindus were killed, raped or forced to flee.
As a conservative estimate, generals of Timur slaughtered or enslaved atleast 7.5 Lakh Hindus in just one day, the day of victory in Delhi.
Before the arrival of Islamic invaders, Hindu population was 600 million, and in 1500 AD, it had reduced to 200 million.
Akbar, celebrated as "the great Mogul," was one of the cruel perpetrators out of the Islamic invaders. He had 5000 Hindu "infidels" in his harem.


text:
Q: Is the ECSA shooting range a public or private facility?
A: ECSA provides a private shooting range for use by its members and their guests.
Q: I'm not a member, how do I get access to the range?
A: Non-members can either join ECSA or access the range as a guest of an ECSA member. In addition, ECSA hosts public Open Range Days once a month throughout the shooting season. Open Range Days are posted on the web site calendar and on the ECSA Facebook page. Flyers with the events schedule are posted at various businesses throughout the county. There are numerous other events throughout the year where non-members can either watch, or participate.
Q: Are there opportunities for my kids to shoot at the range?
A: Yes! ECSA hosts an annual Youth Shoot competition where kids can shoot .22 caliber rifles in two different age groups: 8 to 11, and 13 to 17 under the supervision of NRA-certified Range Safety Officers. Some great prizes are awarded as well! The NRA 3GE (3-Gun Experience) is another popular event where kids and adults compete in 3 stages with a .22 caliber semi-automatic pistol, an AR style .22 caliber semi-automatic rifle, and their choice of a .410 gauge, 20 gauge or 12 gauge shotgun. ECSA furnishes the guns and the ammo for both of these events.
Q: How big is Eagle Cap Shooters Association?
A: As of December 2020, there are 386 voting members.
Q: What type of organization is Eagle Cap Shooters Association?
A: ECSA is a 501(c)4 non-profit charitable corporation.
Q: How long has Eagle Cap Shooters Association been around?
A: ECSA was established in 2002 and was tentatively known as "Wallowa County Rifle and Pistol Range and Club". A comprehensive historical document is under development and will soon be posted on this web site.
Q: What is the Eagle Cap Shooters Educational Alliance?
A: The ECSEA is a 501(c)3 non-profit charitable organization which provides educational classes and programs related to firearm safety and Hunter Education.
Q: Can I make a tax-deductible donation?
A: Yes, donations made to the Eagle Cap Shooters Educational Alliance are tax-deductible. Tax deductible receipts will be provided for all donations made to the ECSEA. Your donations are always appreciated and have greatly helped to enhance the range facilities and enabled us to provide firearm education and safety training, particularly for the youth in our community. Donations can be made in the form of cash, equipment rental, labor, or materials and equipment. Please mail cash donations to this address and specify how you would like the funds to be used (e.g., the new education building project, scholarships, hunter education, etc.).
Attn: Donations
Joseph, OR 97846
Q: What are the hours of operation for the shooting range?
A: This is an outdoor shooting range facility only. The ECSA shooting range is unattended and there is no retail store or indoor range onsite. The range is accessible to members and their guests 7 days a week. Shooting is permitted from 7:00 am to 8:00 pm. In the winter, the County plows Ant Flat Road to the range gate. The range is normally accessible in the winter, but dress warm – it gets windy out there!


patio styles all garden pictures french style patio patio styles ideas.
patio styles budget patio patio furniture different styles.
patio styles back garden patio ideas designs patio design ideas 2018.
patio styles patio door styles.
patio styles see how of used outdoor patio furniture to transform her backyard into a patio door styles uk.
patio styles patio furniture different styles.
patio styles view some patio styles patio style longwood.
patio styles flagstone patio roof styles.
patio styles if you have a modern house or would simply like to spruce up your backyard with a more contemporary style this type of patio is for you patio styles ideas.
patio styles large size of patio ideas as well as patio ceiling fans with patio patio door styles exterior.
patio styles alfresco patio roof ideas australia.
patio styles red brick patio red brick can easily adapt both to formal and informal decor styles red patio styles ideas.
patio styles flagstone patio door styles uk.
patio styles dome patio designs great patios patio roof ideas nz.
patio styles brick patio designs s ideas styles landscape design brick patio designs patio door styles exterior.
patio styles see how of used outdoor patio furniture to transform her backyard into a patio furniture styles.
patio styles creative of patio styles ideas fair stone for patio with home interior remodel ideas with stone patio furniture different styles.
patio styles different patio door styles.
patio styles patio designs patio door styles exterior.
patio styles concrete patio furniture patio styles pictures.
patio styles brick patio designs backyard brick patio ideas regarding brick patio design ideas brick patio styles brick patio ideas patio chair styles.
patio styles patio roofs awnings patio styles ideas.
patio styles style patio patio ideas with style applying different patio decorating ideas in different patio styles style patio patio roof ideas cheap.


text:
Wichita Falls Bancshares, Inc. Announces Acquisition of Chico Bancorp, Inc.
PR Newswire December 17, 2019
WICHITA FALLS, Texas, Dec. 17, 2019 /PRNewswire/ -- First National Bank, a community based bank with locations across four counties in North Texas and its holding company, Wichita Falls Bancshares, Inc., announced today the signing of a definitive agreement to acquire Chico Bancorp, Inc. and its wholly owned subsidiary, First State Bank which serves four locations in Wise County. The agreement has been unanimously approved by the directors of both entities' Boards of Directors and is expected to close in the first quarter of 2020.
This acquisition is an expansion of First National Bank's current market presence and will enhance First State Bank's presence and product offerings to its holders of almost 10,000 accounts in Wise County and the surrounding area. First National Bank will continue its emphasis on growth with a commitment to providing quality financial services that are safe, secure, and competitive with uncompromised integrity to its account holders and to the communities it serves.
Cindy Campbell, President and CEO of First National Bank expressed: "The relationship we have built with First State Bank leading up to joining our organization has been one we are excited to have developed. First National Bank's acquisition of First State Bank is the first in our 33-year history and we are pleased to have found such a complementary fit. Together we will be more than $700 million in assets. United, we are strategically positioned to better compete in our markets while continuing our growth strategy. We are genuinely looking forward to working with the First State Bank team to get to know its staff, customers and the communities they serve."
Steve Holt, President and CEO of First State Bank noted: "This merger will improve our ability to service our customers and the demands of a rapidly growing community, while maintaining our commitment to our employees and those we serve. The mutual approach to banking, the respect and gratitude for our customers who trust in both institutions for their financial needs, makes this a positive relationship for all of us. We welcome First National Bank to our community as we carry on the tradition of relationships."
The merger is subject to customary closing conditions, including the receipt of regulatory and Chico shareholder approvals.
John Gosser of Griffin Financial Group LLC served as financial advisor and Robert Flowers of Fenimore Kay Harrison Ford, LLP served as legal advisor to Wichita Falls Bancshares in the transaction. Hillworth, LLC acted as financial advisor and Larry Temple acted as legal advisor to Chico Bancorp.
View original content:http://www.prnewswire.com/news-releases/wichita-falls-bancshares-inc-announces-acquisition-of-chico-bancorp-inc-300976487.html
SOURCE Wichita Falls Bancshares, Inc.
Grubhub is a 'trojan horse' for small businesses: New York City councilman
Stock Market Live Updates: Stocks slide, Black Friday on track for record year


superstore, specializing exclusively in Dirty Hand Tools Wood Chippers, DHT Wood Chippers and Dirty Hand Tools Chipper Shredders. Compare Dirty Hand Tools Wood Chipper models, specs and prices. Consult with our experienced Dirty Hand Tools Chipper experts. Dirty Hand Tools Chippers for sale.


text:
When will Omicron peak? Pay attention to experts – NBC Chicago
By Mitzi Trainor On Jan 6, 2022
If Omicron COVID cases continue to rise and many states across the country are reporting record cases, when could the variant peak?
Chicago's top medical doctor offered her predictions based on data from around the world on Tuesday but said briefly, "We don't know when Omicron will peak." However, there are some signs that experts look out for.
"I've talked to the model builders and the epidemiologists," said Dr. Allison Arwady, commissioner for the Chicago Department of Health, at a news conference Tuesday. "In South Africa, the first place where this huge surge of Omicron was really recognized and observed, it took about four weeks for the Omicron to peak and then a few more weeks for it to really go back down."
However, South Africa is different from many countries currently experiencing the increase "in many ways, including high infection rates, different vaccination rates, a much younger population with an average age below 30."
"Just a different population overall," said Arwady. "So in the best case scenario, we would probably expect a peak in the first half of January, we say."
Arwady said Tuesday she was 85-90% confident that Chicago would see a peak in Omicron cases in January, but only 50% confident that the peak would peak in the first half of the month.
She said the best indicator of what could happen here is by observing flight paths in Europe, the UK and even New York City.
"We are watching very closely what is happening in Europe and the UK because after seeing this surge in southern Africa the next place we actually saw an omicron surge was in the UK, in Europe, signs of a decrease these settings. It's always a bit tricky around the holidays because the tests just pause in different ways. We've definitely seen signs of slowing growth that we've seen here in Chicago, but I will rest my mind when I start to see some of those numbers go down again. "
Arwady said if the numbers start to decline in Europe or New York in the next two weeks, she expects Chicago to follow "about a week later".
"We'll know in a week or so much more, I think, mostly with a view to Europe, but in the meantime you know that now is the time to really get really vaccinated and, most importantly, to protect the hospitals ", she said.
Their predictions follow similar predictions made by Dr. Anthony Fauci, the White House's leading medical advisor, on Wednesday predicted that the recent wave in the US could peak by the end of January.
"Given the size of our country and the variety of vaccinations and non-vaccinations, I would imagine it will probably be more than a couple of weeks, probably by the end of January," Fauci said on CNBC's "Closing" bell. "
Chicago Mayor Lori Lightfoot also said this week that she expects the Omicron variant "certainly to peak by mid-January, if not a little later".
Currently, Chicago reports the highest case rate in the entire pandemic, averaging 4,591 cases per day.
While she found the increase was partly due to an increase in tests over the holidays, many of which were done at home or for children in schools, the city's positivity rate is 23.6%, "the highest since the first wave ". the pandemic. "
Intensive care hospital admissions have also increased, nearing levels reported in December 2020, but remain below the peak of the pandemic.
On Tuesday, the city recorded an average of 110 COVID hospital admissions per day.
"When we look at hospital stays, of course, that's what makes me pause, that's what I watch most closely," said Arwady. "The fact that we are seeing these high hospital admissions numbers is what holds me the most."
Arwady added that more than 90% of people hospitalized or in intensive care with COVID are unvaccinated.
It's a trend across the state that broke a pandemic record for hospital stays on Monday.
Governor JB Pritzker has already asked hospitals to suspend elective and non-emergency procedures in anticipation of more COVID-19 patients and the staffing of vaccination centers.
Also starting Monday, the city of Chicago and surrounding Cook County will require proof of COVID-19 vaccines in indoor areas such as restaurants, gyms and museums.
Mitzi Trainor 413 posts 0 comments
A New Paradigm Is Needed: Top Experts Question the Value of Advance Care Planning
St. Charles City Council rejects the vaccination mandate
Driver killed, woman critically injured in crash in Chicago's Sauganash…
5 positions the Chicago Bears need to address in the 2022 offseason
Antetokounmpo and Milwaukee face off against DeRozan and the Bulls
Chicago Fire Delivered Some Romantic Developments Before The Break, And One Could…


This statistic shows the leading ten digital console games based on digital revenue in the United Kingdom (UK) in March 2017. During the period of consideration, the total digital revenue of sports video game FIFA 17 amounted to 7.38 million British pounds, making it the most popular digital console game that month. Tom Clancy's Ghost Recon: Wikilands by Ubisoft with digital revenues of 4.53 million British pounds and EA's Batterfield 1 with digital revenues of 4.21 million British pounds ranked second and third.
Everything On "Gaming consoles in the United Kingdom (UK)" in One Document: Edited and Divided into Handy Chapters. Including Detailed References.


Though I am most certainly not one of the many bowl season detractors who crawl out of the woodwork every year, the stop-and-go nature of the bowl season's early half is somewhat annoying.
The postseason began with a splash on Saturday, featuring five FBS bowls, and a sixth offering from the FCS. It felt almost like a true college football Saturday, with action kicking off in the morning here on the West Coast, and ending in prime time. That initial dive into bowls was the prelude to two days off, and a sprinkling of a bowl game-per-day from Tuesday through Thursday, and two games on Friday.
Your reminder: Thank ESPN for the expansive bowl season, as the Worldwide Leader owns and operates many of the games, and they thus exist for television inventory.
I will not look a college football gift horse in the mouth, as it were. We have five pre-Christmas bowl games to enjoy during the week! It's not a full six-pack, but it's close enough.
Seeing as this isn't a complete Saturday Six-Pack, your beer recommendation is not available in sixers. If you are coming home from your excruciatingly long last days at work before the holiday break, or have endured a brutal day shopping in preparation for Dec. 25, a bomber of Port Brewing's Santa's Little Helper paired with a bowl game should restore your cheer.
It's an imperial stout, so it's a heavier beer; almost a dessert drink. I live near Port's base of operations, so there's a greater-than-zero percent chance I'll toast the holidays with a pint of it in the coming days.
When bowl pairings were announced earlier this month, Conference USA champion FAU's draw of an Akron team that finished 7-6 and lost the MAC Championship by 17 points immediately caught my attention. This is, without question, the most lopsided matchup of the bowl season — so much so, that I almost want to overthink it.
FAU enjoyed a breakthrough season under its first-year coach. You may have heard something about him at some point this season; the guy's name is Lane Kiffin. Thus far, everything about the Kiffin experiment exceeded my expectations — including his signing a 10-year contract extension just today.
While some have speculated Kiffin would leave for another job during this coaching cycle, perhaps this really is an ideal fit for him. FAU has the potential to become a perennial Group of Five powerhouse, and Kiffin can do his thing without the microscopic focus that contributed to USC's struggles in his time there.
In some ways, Kiffin's comparable to his bowl-game opponent, Terry Bowden. Bowden spent years away from coaching altogether after the tumultuous split he made with Auburn. He returned at Div. II North Alabama, and has breathed life into a recently moribund Akron program. The Zips winning MAC East this season and getting to their second bowl game in three seasons is a considerable accomplishment.
Unfortunately, poor Akron's 2017 postseason will not end as favorably as 2015.
The Zips rank No. 100 against the run in FBS. Trying to stop FAU running back Devin Singletary — whose 29 rushing touchdowns lead the nation — should prove futile. Singeltary needs 204 yards to finish the season at 2,000; given the Zips allow a shade below 200 per game, it's certainly not out of the realm of possibility.
Don't expect this one to be close. If you entered into a Bowl Pool, I hope you assigned this one maximum confidence points.
Fare thee well, Miami Beach Bowl. We hardly knew ye.
In its brief history, the Miami Beach Bowl was noteworthy mostly for a great Memphis-BYU game, which was completely overshadowed by an ugly melee.
And that was in its first year! With a dubious start and awful attendance for its duration, the Miami Beach Bowl moved to the home of the FCS National Championship Game: Frisco, Texas. No word yet on if the winner of SMU-Louisiana Tech will face the winner of James Madison-North Dakota State, but they should.
The inaugural Frisco Bowl is the unofficial Sonny Dykes, as the air-raid disciple began his head-coaching career at Louisiana Tech, and returns to the ranks following a one-year layoff with SMU, replacing Chad Morris.
Quarterback Ben Hicks comes in with 32 touchdown passes on the season, playing with one of the most explosive wide receiving corps in the nation. Trey Quinn and Courtland Sutton are two of the top 27 most prolific pass-catchers in college football, and both are destined for NFL careers.
Since Dykes' departure for Cal in 2013, Louisiana Tech reinvented its image as a defense-first program under Skip Holtz. Though the Bulldogs still flourished with an aggressive offense the last few years, including Jeff Driskel's career resurgence in 2015, NFL caliber defensive talent has shaped Tech. In 2017, outstanding defensive end Jaylon Ferguson sets the table and the Tech secondary clears it with 16 interceptions.
Tech needs to generate takeaways to limit SMU's prolific passing attack. Otherwise, the Mustangs should roll.
First-year head coaches Geoff Collins and Butch Davis both exceeded expectations in 2017, albeit for different reasons. Long the dregs of FBS, Temple football began to gain momentum under Al Golden in the late 2000s. His departure for Miami after 2010 brought on Steve Addazzio, who had one outstanding and one middling season. Matt Rhule struggled mightily initially, but quickly got Temple to a level not just meeting that of Golden and Addazzio's peak, but actually surpassing it.
Rhule's teams reached the Top 25 and won the American Athletic Conference, but his departure last offseason for a Baylor program headed for a structural rebuilding suggested that Temple maxed out. That initial dip that began under Addazzio and carried over into Rhule's first year speaks of the difficulty of maintaining success at Temple. The Owls should have taken a massive step back in 2017 — and sorta did, to be honest — but the regression was not nearly as severe as one might anticipate. What's more, the Owls finished the regular season, winning three of their last four, including one over Navy, to get bowl eligible.
Butch Davis took over a much different situation at FIU, inheriting the smoldering wreckage that was the Ron Turner era. Pete Garcia's abrupt firing of Mario Cristobal just a year removed from the Panthers appearing in only their second bowl game, and two years after winning the Sun Belt, sent the once-promising program into a tailspin.
Davis was an excellent hire, given his track record in South Florida at the University of Miami, but it seemed he would need time to get FIU moving in a positive direction. All Davis accomplished in Year 1 was win eight games and lead the Panthers to just their third bowl game ever.
A low-scoring game seems likely. Since Golden's tenure, Temple staked its reputation on defensive football, which culminated with the Owls ranking 11th nationally in points allowed a season ago. This year's team plummeted to No. 73, but still has playmakers in defensive back Delvon Randall and the outstanding defensive line tandem of Sharif Finch and Jacob Martin.
FIU is similarly constructed, featuring talent in the front seven with defensive end Fermin Silva and linebackers Treyvon Williams and Anthony Wint.
The Panthers failed to score into the 20s in four of their first five games, but came alive for point totals of 41 (twice) and 63 in the back-half of the regular season. Temple saved its highest output, 43 points, for the regular-season finale and bowl-clinching defeat of Tulsa. Frankie Nutile taking over as starting quarterback helped kick-start Temple's offense in the latter portion of the campaign, while FIU senior Alex McGough played his best ball down the stretch.
The similarities should make for an exciting game.
I have been vehement here at The Open Man that UAB's Bill Clark was the only rational choice for National Coach of the Year. Voters proved their lack of creativity, particularly the AP, which voted Clark sixth in the race. Whatever. If UAB completes its unprecedented season, #TheReturn, with a Bahamas Bowl defeat of Ohio, I'll feel personally vindicated.
Oh, and it would be a fitting way for the Blazers to cap things off, too.
UAB is playing its first bowl game in 13 years, which could factor into the game's flow. It's not unlike Eastern Michigan a season ago, which participated in this same bowl game against Old Dominion, marking the end of an almost 30-year bowl drought. The Eagles fell behind by two scores early, and despite battling back, could never gain the lead.
UAB as bowl newbies stand in stark contrast to Ohio, a program that Frank Solich quietly built into a perennial winner. This marks the Bobcats' eighth postseason appearance since 2009, and third straight.
While UAB attempts to win the first bowl in program history, Ohio U. has not been much better. The Bobcats' 2011 Famous Idaho Potato Bowl defeat of Utah State marked the program's first-ever bowl win. They won the St. Petersburg Bowl the following year, but now ride a three-game losing skid.
For Ohio to win this time around, the Bobcats must contain a multidimensional UAB rushing attack. The Blazers roll with an outstanding feature back in Spencer Brown, the breakout freshman star who put up more than 1,200 yards rushing. Coupled with quarterback A.J. Erdely, who rushed for 13 touchdowns, UAB will throw different looks at an Ohio defense that ranked 11th nationally against the rush.
Erdely does not commit many mistakes in the passing game, throwing just four interceptions all season and completing 62 percent of his attempts, but he threw fewer than 300 passes. Establishing the run is critical for UAB to strike the balance on which it has thrived, and that may prove difficult Quentin Poling and the rest of the Ohio front seven.
The variables of this game that go beyond the players involved make this one of the more fascinating bowls to pick. So many factors favor Central Michigan, as the Chippewas come in hot, winners of their last five straight. Central Michigan also vastly exceeded expectations in 2017, getting to eight wins despite being tabbed for fifth place in the MAC West. As a general rule of thumb in bowl games, I prefer a season-long overachiever to an underachiever seeking one last shot at glory.
And, indeed, Wyoming did not quite live up to the expectations established in a breakout 2016. The Cowboys won the Mountain West's Mountain division a season ago and even hosted the conference championship game. Despite losing some key pieces, the return of celebrated NFL prospect Josh Allen was enough to earn Wyoming modest support as a potential spoiler to Boise State.
The Cowboys finished tied for second in the Mountain, which isn't a failure by any stretch. Still, a late-season dip sends them into the bowl game on the wrong trajectory compared to that of Central Michigan.
And yet, Wyoming has the advantage of playing closer to home, in a stadium with which it's familiar and already saw once previously this season. Elevation is much less of a factor for the Cowboys, dropping 5,000 feet from their typical environment, while Central Michigan climbs nearly 2,000 feet.
So, assuming these external factors are a wash, let's get down to the players. Allen's been the focal point of Wyoming's season, and never quite delivered the numbers one would anticipate of a potential first-round draft pick. He's thrown just 13 touchdowns and completed fewer than 59 percent of his pass attempts, partially the result of a shoulder injury — a shoulder injury that could affect him still on Friday.
Conversely, Central Michigan was excellent against the pass all season, allowing just 13 touchdown throws against 19 interceptions. The Chips' 19 picks rank second-most in the nation. Josh Cox and Sean Bunting account for 11 of those interceptions. They could cause headaches for Craig Bohl's bunch, even without generating takeaways. If Wyoming's rendered ineffective with the pass, the Cowboys struggled mightily running the ball this season.
Wyoming may be the favorite, but the factors in Central Michigan's favor just seem too overwhelming for me to not project a multiple-score Chip win.


text:
SPORTSENGINE PARTNERS WITH PREP HOOPS TO PRESENT YOUTH BASKETBALL TOURNAMENT SERIES
Grassroots tournament series will have nine U.S. metro stops in first year tour
MINNEAPOLIS, MINN – November 16, 2017 – SportsEngine Inc., the leading youth sports technology provider, announced today a partnership with Prep Hoops, a national grassroots basketball media and event company, to present the inaugural Prep Hoops Series powered by SportsEngine, a youth basketball tournament series that will travel to nine U.S. cities in the spring and summer of 2018.
SportsEngine, a division of NBC Sports Group, is trusted by over 750,000 sports teams to run their websites, tournaments, leagues, online registration and mobile apps. With the inception of the Prep Hoops Series, all participating teams will have the option to get a free SportsEngine-hosted and designed website for their organization that will allow access to schedules, rosters and team stats throughout the year. In addition, SportsEngine's owned basketball media properties, D1 Circuit and Prep Circuit, along with Prep Hoops contributors will garner maximum exposure for teams and individual athletes.
Prep Hoops' presence in the grassroots basketball industry comes with a reputation of executing successful tournaments and events around the country for college hopefuls, in addition to publicizing the teams and athletes involved. This new tournament series alone will gain the attention of over 100 national scouts in search of stock risers, under the radar prospects and breakout teams at all levels of competition and recruitment.
"Traditionally, many of our basketball customers have been connected to us through our technology solutions," said Jody Vogelaar, VP Marketing, SportsEngine. "This partnership is a great opportunity for us to be able to help those clubs, teams and players get exposure to scouts through the media component of our business."
"We are excited to team up with SportsEngine to present a new set of tournaments for teams in all areas of the country," said Nick Carroll, Co-Founder of Prep Hoops. "The added level of technology support and media coverage for participants is something we have been wanting to provide attending teams since we started our company in 2012."
The Prep Hoops Series will take place April-July 2018 and will touch down at nine different metro locations across the United States, eventually culminating with a national championship in Knoxville, Tennessee. Each event will feature tournament play for age level 13U-17U.
Full Prep Hoops Series Schedule
April 6-8 – Los Angeles (Sports Academy)
May 4-6 – Kansas City (Sports Pavilion Lawrence)
May 11-13 – Myrtle Beach (MB Sports Center)
May 18-20 – Las Vegas (Tarkanian Basketball Academy)
May 25-27 – Orlando (Big House Sports Complex)
June 29-July 1 – Dallas (The Fieldhouse-Grapevine)
July 11-15 – Cincinnati (Nothin But Net)
July 18-22 – Fayetteville, AR (Whitaker Sports Center)
July 25-29 – Knoxville, TN (Rocky Top Sports World)
To register for the tournament series visit www.PrepHoopsSeries.com or email info@prephoopsseries.com
About SportsEngine
Helping the world play smarter and live more, SportsEngine, Inc., an NBC Sports Group company, is the leading provider of Sport Life Management mobile applications for coaches, parents, and athletes and Sports Relationship Management tools for governing bodies, leagues, clubs, associations and events. SportsEngine, Inc. powers over 750,000 teams, leagues, and clubs, helping them manage, connect, and communicate with a diverse range of stakeholders, including athletes, parents, administrators, coaches, referees, scouts, volunteers, fans, journalists, and sponsors. Founded in 2008, SportsEngine, Inc. is based in Minneapolis, MN. For more information, please visit www.sportsengine.com/solutions; like the company on Facebook at Facebook.com/sportsengine; or follow SportsEngine on Twitter at @sportsengine.
About Prep Hoops
Founded in 2012, Prep Hoops has quickly become America's authority for grassroots basketball coverage and events. Prep Hoops provides a one-of-a-kind event platform, hosting over 20 tournaments and over 50 prospect showcases in over 30 markets throughout the United States. Additionally, with over 100 contributors stationed throughout the country, Prep Hoops publishes close to 20,000 articles annually on players, club teams, and high school programs at all levels of competition and recruitment nationally. Visit www.prephoops.com or follow Prep Hoops on Twitter @PrepHoops.