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The predominance of valid trials ensured expectation of prime-tar
Posted on August 31, 2017 by rafi5252
The predominance of valid trials ensured expectation of prime-target correspondence. The paradigm was presented on an LCD screen (Philips Medical Systems, The Netherlands) located in the rear of the magnet bore, visible to the participants via a mirror mounted on the head coil. Responses were obtained with response grips (Nordic NeuroLab AS, Bergen, Norway) and logged in E-Prime. Paradigm presentation and fMRI scanning were synchronized with a sync-box (Nordic NeuroLab AS, Bergen, Norway). Participants were instructed
to respond as quickly and accurately as possible by pressing a button with their right thumb in response to a target pointing right, and their left thumb to a target pointing left. They practiced the task outside the scanner until complete task compliance. Mean RTs for valid, Talazoparib price invalid and neutral trials were calculated after excluding all trials with commission errors and RT <100 ms. The excluded trials encompassed 3.1% of all trials and were evenly distributed across participants. Daporinad Due to the expectation of prime-target correspondence, cue-primes should decrease the RT in valid relative to neutral trials and increase commission errors in invalid trials. The RT priming effect was estimated by subtracting
RT in valid trials from RT in neutral trials. The percentage commission errors was log-transformed to fit parametric analyses. Right-handed participants respond faster to targets pointing right and make more commission errors with targets pointing left (Avila & Parcet, 2002). Hence, repeated measures ANOVA analyses were used to investigate the effects of both trial type and hand on RT and commission errors, separately, followed by paired t-tests. In linear regression analyses, SR, SR+/SP− and SR+/N− were predictors for RT priming effect and commission errors in invalid trials for each hand separately and for both hands combined.
MR images were acquired on a Philips Intera 3 Tesla scanner (Philips Medical Systems, Best, The Netherlands) with Quasar Dual gradients Florfenicol using a six-channel SENSE head-coil (InVivo, Gainesville, USA). The participants' heads were immobilized using foam padding. During the task, T2∗-weighted gradient-echo single-shot echo-planar-imaging whole brain measurements were obtained with 42 contiguous axial slices, slice thickness = 4.0 mm, TR = 1800 ms, TE = 35 ms, flip angle = 90°, SENSE reduction factor = 2.2, field-of-view = 256, and in plane voxel resolution 2 × 2 mm. Four functional runs, each consisting of 182 volumes, were acquired in each participant. Every run was preceded by four dummy scans which were discarded before analysis. A B0 field map was acquired for fMRI scan distortion correction (unwarping) and a 3D MP-RAGE sequence for anatomical reference. Image analyses were carried out in FSL 4.1.5 (Smith et al., 2004).
The hierarchical organization of visual cortex is such that highe
The hierarchical organization of visual cortex is such that higher visual areas take time to integrate information relayed from early visual areas (Einhauser et al., 2007, Todd et al., 2011). As such, while a faster stream of novel pictures (e.g. 4 frames/s) increases sensory stimulation and can elicit more activation in higher visual areas, further increasing presentation rate (e.g.
15 frames/s) will result in failure to adequately process complex information, giving rise to an inverted u-shaped temporal response profile. Using this approach, the parahippocampal place area (PPA) and fusiform face areas (FFA) whose response profiles peak at the slower rates relative to earlier visual areas have been identified as bottlenecks for visual processing 11 and 12]. Lowered rate of visual processing in SD is evidenced by a slower peak rate in the temporal Ruxolitinib response profile in the PPA compared to in the well rested state Nutlin-3a [13•]. The PPA and FFA lie in extrastriate visual cortex and are relatively more sensitive to the degradation of top-down control of attention encountered during SD. In contrast, early visual areas where processing is not limited at the presentation frequencies tested
and which are less sensitive to attentional modulation, demonstrate a monotonic increase in activation with presentation rate irrespective of state (Figure 1). Hence, visual areas that serve as potential bottlenecks for visual
processing Ponatinib research buy in the sleep-deprived state can been identified. Selectivity for object pictures can be measured by examining the difference in PPA responses to attended and unattended house pictures. This index of selectivity is lowered in sleep-deprived persons, when picture stimuli are temporally unpredictable [14]. However, when face and house stimuli appear in a temporally predictable manner, SD results in reduced PPA activation but without an accompanying change in selectivity [15]. This relative improvement in behavioral performance when stimuli are temporally predictable is consistent with similar effects found with vigilance in the well rested state [16]. Reduced spatial selective attention in SD also occurs in the preparatory period preceding stimulus onset and manifests in retinotopically specific visual cortex [17]. The latter indicates that effects of SD manifest in brain areas specifically engaged in the task and are not evident when these areas are not specifically probed. Deficits in attention evidenced by reduced fronto-parietal activation in association with degraded performance are also evident in visual tracking tasks that evaluate deployment of selective attention over a longer period than that spanned by a brief experimental trial 18 and 19•]. These point to a temporally more extensive loss of top-down control of attention than apparent from tests of psychomotor vigilance.
It is obvious that also in vivo experiments are needed but withou
It is obvious that also in vivo experiments are needed but without a good knowledge on the influence of the orogastrointestinal variations on particle parameters and penetration in vivo data may be difficult to interpret. The authors declare that there are no conflicting interests. The authors acknowledge funding by the Austrian Science Fund (FWF) grant P22576-B18 and by the Austrian Research Promotion Agency (FFG) project 826136. "
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as PowerPoint slide A Luisa Guarner se la conocía bajo dos aspectos, uno como profesional de la medicina y otro como persona entrañable. Luisa falleció el pasado 30 de julio a la edad de 63 años, en su domicilio de Sant Gervasi, poco más de un año después de descubrírsele su enfermedad. Durante este tiempo ha sido un ejemplo GDC-0199 in vivo de optimismo, virtud a la que nos tenía acostumbrados. Cursó sus estudios de Medicina en la Universidad de Barcelona y después de realizar la residencia en
el Hospital Clínic se incorporó al Servicio de Gastroenterología de la en aquel entonces Ciudad Sanitaria de la Seguridad Social Valle de Hebron de Barcelona. Rápidamente se aficionó a la Ku-0059436 patología pancreática leyendo, en 1984, su tesis doctoral "Tripsina inmunorreactiva y lipasa séricas: Utilidad en el diagnóstico de enfermedad pancreática". Algunos años mas tarde, en 1989, fue cofundadora de la Asociación Nacional para el Estudio del Páncreas (ANEP), posteriormente convertida en Club Español de Páncreas (CEP), participando siempre activamente con comunicaciones
y comentarios en las Methocarbamol reuniones bianuales. También era miembro activo de la Asociación Española de Gastroenterología desde su fundación en 1999 y de la Sociedad Española de Enfermedades Digestivas. En 2002 fue uno de los editores del primer "Tratado de páncreas exocrino" publicado en España. Este 2012, cuando su enfermedad estaba en avanzada evolución, participó activamente como miembro fundador de la recientemente constituida Societat Catalana de Pàncrees. Participó también asiduamente en las reuniones del European Pancreatic Club en donde tenía, como no, muchos y buenos amigos. Pero desde el punto de vista profesional también se distinguía por su buen hacer. Tenía una capacidad de resolución enorme. Con ella los problemas dejaban de serlo. Su trato con los enfermos era exquisito, no sólo por su capacidad de decisión, sino porque sabía escuchar al paciente, virtud fundamental en cualquier médico pero que no siempre se sabe aplicar. Formaba parte de una gran familia. Era la mayor de ocho hermanos y como tal había ejercido, dando consejo y ayuda adecuada al que lo necesitaba. Cuidó y luchó por sus hijas, Luisi, Sara y Nuria que, junto a su esposo Eduardo, mantendrán siempre un profundo, feliz y alegre recuerdo de ella.
Diagnostic manual compression may help to complete the picture, a
Diagnostic manual compression may help to complete the picture, and guide the choice of treatment. Contralateral BF activity will be visible as CAL-101 solubility dmso the contralateral ASIS moving upwards. This can easily be observed,
but the relevance of that observation remains unclear. In summary, problems with the ASLR may result from failing force closure. Palpation of the movements of both ilia, and of the long dorsal sacroiliac ligaments, as well as manual compression of the pelvis may help to complete the picture. The present study was limited to healthy subjects. Muscles were only studied on the right side, although right and left ASLR were performed. Four sets of TA data could not be used, and outliers were removed before statistical testing. Still, a consistent pattern of significant effects was found, suggesting that power was no major problem. The use of surface EMG for OI and OE in the present study may have affected results. Crosstalk between the OI and OE, and between TA and OI, cannot be excluded. On the other hand, fine-wire EMG of TA would only reflect the activity of the mid region of that muscle, whereas different functional roles of different Epacadostat mw parts of TA have been described (Urquhart and Hodges, 2005). Finally, only women were measured and generalization of our results to
the male population may not be straightforward. The ASLR consists of ipsilateral hip flexion, a contralateral hip extension moment, force closure by the lateral abdominal muscles, sagittal plane pelvis stabilization by the abdominal wall, and activity of contralateral transverse plane rotators of the pelvis. Problems with the ASLR may result from failing force closure. tuclazepam Other tests are available to confirm, or falsify, the clinical hypothesis that the patient is having problems with force closure. Financial support
was obtained from Stryker Howmedica Nederland, Biomet Nederland, and the Dutch Society of Exercise Therapists Cesar and Mensendieck (VvOCM). PWH was supported by a Senior Principal Research Fellowship from the National Health and Medical Research Council (NHMRC) of Australia. The Authors gratefully acknowledge Erwin van Wegen, Mark Scheper, Ilse van Dorst, Annemarie ten Cate, Hans van den Berg, Roland van Esch, and Tijmen van Dam for their help and suggestions. Jan Mens gave very useful suggestions for the interpretation of data, and Darren Beales was friendly enough to share his experiences with similar experiments. We express our thanks to Steve Barker for his skillfull linguistic editing of an earlier version of the text. This project could not have been performed without the stimulating initiative of the late Paul I.J.M. Wuisman, Professor of Orthopedic Surgery at the VU University medical centre.
e right/left knees) Analyses were adjusted for the a priori con
e. right/left knees). Analyses were adjusted for the a priori confounders age and gender, and then additionally for selleck chemicals BMI as a potential mediator. Odds ratios before and after adjustment are presented with 95% confidence intervals (95% CI), and p values from Wald significance
tests. GEE using an identity link function (linear regression allowing for clustering) was used to compare medial compartment minimum JSW (mm) in HBM cases and family controls, adjusting for confounders. The possible mediating role of BMI was then more formally explored using a binary mediation approach with a probit model, and additionally by adjusting for the different components of body mass (fat mass, lean mass etc.) in turn. Analyses were repeated stratified by gender.
Pre-planned sensitivity analyses comprised: i) exclusion of poor quality/rotated/tilted X-rays, ii) a "person-level" analysis of the worst knee in each individual, iii) adding radiographic knee replacements to the dataset, assuming these were performed for OA, iv) excluding HBM cases/controls with self-reported inflammatory arthritis, and v) restricting the analysis to those HBM cases meeting KU-55933 supplier the index case definition at the hip. Data were analysed using Stata release 12 statistical software (StataCorp, College Station, TX, USA). Fig. 1 summarises the selection of radiographs for inclusion in our study. 21 knee joints (n = 1 case, 20 controls) were excluded from the outset due to unacceptable image quality. Knee replacements were also excluded (n = 13 cases, 19 controls). 2546 knees from 1302 individuals were included in the primary combined analysis comprising
609 HBM case knees, 362 family control knees, 1172 ChS control knees and 403 HCS control knees. 1244 individuals contributed two knees to the analysis and 58 individuals contributed only one knee. Table 2 summarises the demographics of the study population. HBM cases were slightly younger than the combined controls (mean 60.8 years vs. 63.4 years), with a lower proportion of females (74.3% vs. see more 81.3%). As expected, HBM cases had substantially higher values for standardised BMD at both the hip and lumbar spine compared with controls. Mean BMI was also greater in cases than controls (30.6 vs. 27.3 kg/m2). The prevalence of the different OA outcomes is shown for HBM cases, each separate control group, and all control groups combined (Table 3). The prevalence of radiographic knee OA (defined as KL grade ≥ 2) was 31.5% in HBM cases and 20.9% in the combined controls (p < 0.001); as expected this was identical to the prevalence of any osteophyte (≥ grade 1). Moderate osteophytes (≥ grade 2), moderate JSN (≥ grade 2) and chondrocalcinosis were also more prevalent in HBM cases.
The presence of an orofacial cleft has severe and long-lasting ad
The presence of an orofacial cleft has severe and long-lasting adverse effects on both physical and psychological development and imposes a substantial social and economic burden. In the United States, for example, the lifetime cost for treating orofacial clefting see more has been estimated to be approximately $US101,000 [3]. Prevention of abnormal palatogenesis has been hampered
by a shortage of information about modifiable risk factors. Nonsyndromic cleft lip with or without cleft palate (CL/P) is one of the most common human birth defects, with an average worldwide prevalence of 1.2/1,000 live births [1, 2, 4]. In Poland, the rate of occurrence of this common malformation is 1.7/1,000 [5]. The incidence correlates with geographic origin, racial and ethnic background. Concordance of orofacial clefts in monozygotic twins ranges between 40% and 60%, suggesting a role for environmental factors and exposure conditions i.e. nutritional deficiencies, toxins, physical constraint in utero. Increased phenotypic variances and asymmetry for craniofacial measurements in parents of CL/P-affected UMI-77 price children, as well as high recurrence risks (20–30 times greater than population prevalences) provide evidence for a strong genetic
component to clefting. Since the mother is the environment of the developing embryo, interactions between genetic and lifestyle factors are assumed to be involved in abnormal palatogenesis. Based on experimental and epidemiological data, CL/P etiology is considered to be complex, multifactorial, and determined by numerous interacting gene loci with additional environmental covariates [1, 2, 6., 7., 8., 9., 10. and 11..
In the human genome, only a difference of about 1.6% between modern humans and the most developed primates has been found. In contrast, human dietary habits have markedly evolved since origin, about 2–7 million years ago, especially during the last century. The per capita consumption of refined sugar has increased from 0.5 kg/year in 1850 to about 50 kg/year in the recent decade. The concept of environment is complex Cell press and broad, and it has been frequently associated with pollutants, infections, risky behaviors, etc. However, food intake is the environmental factor to which we are all permanently exposed from conception, and it has been a major driving force through species' evolution [12]. Therefore, dietary habits and nutrient intakes are the most important environmental factors modulating gene expression during one's life span. The several lines of evidence support an association between maternal nutrition and risk of clefting in offspring [4, 13]. However, in the majority of individuals with CL/P a specific causative agent cannot be identified, and the detailed proportion of cases of clefts that are potentially preventable through changes in maternal nutrition and other lifestyle choices is currently unknown.
The total release of chromium was determined in wells containing
The total release of chromium was determined in wells containing 51Cr-labeled cells with RPMI 1640, 10% FBS with 10% triton X-100. Spontaneous release was always MEK inhibitor review less than 10% of total release. NKCA was calculated as the mean of triplicate determinations for each E:T ratio and was expressed as percentage lysis, calculated as follows: %lysis=mean experimental counts per minute-mean spontaneous counts per minutemean maximum counts per minute-mean spontaneous counts per minute×100 The necessary sample size for our observations was calculated
using SigmaStat software (Jandel Scientific, San Rafael, CA), as described previously (Raso et al., 2007), with α = 0.05 and β = 0.20. A one-sample Kolmogorov–Smirnov test demonstrated the normality of data distribution for all measured variables. Basic data buy BMS-754807 are presented as means ± standard error of the mean. Independent sample "t" tests compared subjects grouped according to their fitness percentile (i.e., P0 − P50versus P50 − P100) for aerobic power and muscle strength. Univariate and hierarchical multiple regression analysis investigated
associations of phenotypic and functional immunological parameters with aerobic power, muscle strength and mood state. Bonferroni corrections were applied where appropriate. All analyses were performed using Predictive Analytics Software 17.0 for Windows package (PASW, Inc., Chicago, IL). With few exceptions, subjects fell into the "young-old" age category. Scores for the various measures of fitness, mood state and carbohydrate intake were all at the levels anticipated for relatively inactive but otherwise healthy individuals in this age category (Table 1). The average body mass index was only a little above the ideal range, and the average participant was obtaining <40% of the estimated total energy intake of 6.90 ± 0.34 MJ day−1; Cobimetinib supplier 1659 ± 81 kcal day−1 from carbohydrate; however, there were wide inter-individual differences, probably due
in part to imprecise reporting and some under-reporting of overall food consumption. When aerobic power values were used to classify subjects into upper and lower halves of a fitness continuum, fitter subjects had a lower BMI (P = .033), body fat content (P = .001), and muscle strength (P = .041) ( Table 1). However, there were no significant differences of general physical characteristics when subjects were categorized in terms of muscle strength. Scores for the psychobiological variables (depression, fatigue and quality of life) were not significantly influenced by either measure of fitness. Values for a wide range of immune parameters are summarized in Table 2, with arrows indicating the anticipated trend of older individuals relative to published values for young women.
While South Georgia has a yearly average soil temperature of +1 8
While South Georgia has a yearly average soil temperature of +1.8 °C and winter values that rarely fall below −2 °C ( Heilbronn
and Walton, 1984), temperatures below −10 °C on Signy Island are not uncommon and the average is approximately 4.5 °C lower than on South Georgia ( Davey et al., 1992). This fly spends the majority of its biennial life cycle as a larva, with the non-feeding adults only emerging and being active for a short period in mid-summer on Signy Island (Convey and Block, 1996). The larvae are therefore exposed to the full range of environmental conditions on the island over the annual cycle. To determine the pre-adaptive VE 821 capacity of E. murphyi, Worland (2010) examined the level of freeze-tolerance and long-term acclimatory ability of larvae. Prior to acclimation, larvae exhibited moderate freeze-tolerance, with an LTemp50 of −13.19 °C, ∼7 °C lower than their SCP (−5.75 to −6.15 °C). Following 12 d at −4 °C, their LTemp50 decreased to below −20 °C.
Such an increase in cold tolerance would allow larvae to survive temperature conditions at the soil surface on Signy Island at any time throughout the year. However, their capacity to survive over short time-scales while in an un-acclimated state, including their ability to rapidly cold harden, is unknown. Rapid cold hardening (RCH) is defined as the rapid induction (minutes to hours) Selleckchem CP-673451 of tolerance to otherwise harmful low temperatures of (Lee et al., 2006b and Yi et al., 2007). It was first described in the flesh fly, Sarcophaga crassipalpis, by Lee et al. (1987), and has since been observed in a wide range of organisms, including polar invertebrates such as the collembolan, Cryptopygus antarcticus, the mites, Alaskozetes antarcticus and Halozetes belgicae (
Worland and Convey, 2001 and Hawes et al., 2007), and the midge, Belgica antarctica ( Lee et al., 2006b). The presence of RCH in Antarctic invertebrates is perhaps unsurprising given that it allows organisms to adjust rapidly to sharp changes in environmental temperatures, particularly those near to ecological and physiological thresholds, which are a hallmark of the Antarctic climate ( Convey, 1997). Although the ecological role of RCH is well established, relatively little is known about the mechanisms underlying the response. It was originally thought to involve cryoprotectants, such as glycerol, alanine and glutamine (Chen et al., 1987), but, as increasing numbers of species were found to possess the response in the absence of these compounds (e.g. Kelty and Lee, 1999 and Lee et al., 2006b), the suggestion of cryoprotectants playing a universal role was abandoned. Now, RCH is thought to be involved more with protection against cold induced apoptosis, as shown in Drosophila melanogaster and S. crassipalpis ( Yi et al., 2007 and Yi and Lee, 2011), and with maintenance of membrane fluidity, as shown in B. antarctica ( Lee et al.
As the concentration
of water miscible solvent increases,
of water miscible solvent increases, a decrease in the size of particle can be achieved (Mohanraj & Chen, 2006). In preliminary tests, the bixin concentrations tested in the bixin nanocapsule formulations were 100, 58, 37, 16 and 11 μg/mL; these were stored under ambient conditions (25 ± 1 °C) in amber glasses, and the parameter of size distribution was evaluated periodically during three weeks. Based on the nanocapsules stability, an optimal formulation was prepared in triplicate and was characterised in terms of viscosity, bixin content, encapsulation selleck kinase inhibitor efficiency, pH, diameter, zeta-potential and colour. Moreover, the stability of the optimum formulation was studied during storage at ambient temperature. The pH, diameter and bixin concentration were evaluated weekly for 9 weeks; after this period, the evaluation was performed every 2 weeks up to 119 days of storage. The viscosity of the bixin nanocapsule suspension was measured immediately after preparation using a Brookfield rotational viscometer (model DV-II + Pro, spindle LV2, Brookfield Engineering, USA) at 25 °C. Data were analysed
using Brookfield Rheocalc 32 software. The bixin nanocapsule suspension (optimal formulation) (10 mL) and a free bixin solution (10 mL) were analysed using a portable colorimeter (Konica Minolta model CR 400, Singapore). Both samples were prepared Linsitinib cell line in triplicate in the same bixin concentration (16.92 μg/mL). The free bixin was solubilised in ethanol:water (2:8) due to the low solubility of bixin in pure water. The colorimetric parameters were obtained C59 according to the Comission Internationale de l'Eclairage (CIELAB system); the coordinates
were L∗ (lightness), and the colour coordinates a∗ (red-green component) and b∗ (yellow-blue component), which were measured using the illuminant D65 and an angle of viewing of 0°. The total content of bixin was determined through the extraction of bixin from the bixin nanocapsule suspension. This method consisted of the extraction from an aliquot of 250 μL of formulation with acetonitrile (4.75 mL). This extract was sonicated by ultrasound (30 min) and centrifuged (15 min at 2820×g). The supernatant was injected in the HPLC. The bixin content in the aqueous phase of the bixin nanocapsule suspension was determined through the injection of the filtrate in the HPLC. The filtrate was obtained after the ultrafiltration/centrifugation of an aliquot of bixin nanocapsule suspension (400 μL) using a Ultrafree-MC® (10,000 MW, Millipore, Bedford, USA) in a centrifuge (15 min at 1690×g). The encapsulation efficiency was determined according to the method of Venturini et al.
1D) In addition, the adventitious root induction rate of CS was
1D). In addition, the adventitious root induction rate of CS was 9% higher than that of CP (Fig. 1E). http://www.selleckchem.com/products/kpt-330.html This indicates that CS is better suited for adventitious root induction and growth under these conditions. We generated a total of 90,242,024 and 82,011,294 raw reads from CP and CS, respectively (Table 1). After trimming the low-quality reads with Phred quality scores of ≤25 and removing primer/adaptor sequences, we obtained 85,335,736 (94.5%) and 77,583,736 (94.6%) high-quality reads, with an average read length of 99 bp, in CP and CS, respectively
(Table 1). To obtain high-quality assemblies, we tested several algorithms for de novo assembly with different options. We used several criteria to determine the desirable assembly: number of reads used in the assembly, total length of transcriptome, average contig length, N50, and annotation by BLASTX against the TAIR protein database. Using Velvet followed by Oases, we compared assembly results with randomly selected k-mer lengths of 31, 39, 41, 49, 51, 59, 61, 69, 71, and 79. The best assembly was obtained at k = 69, as it resulted in the highest total length (∼138 Mbp), the largest N50 length (1,092 bp), the largest average
contig length (19,999 bp), and a significant number of TAIR hits (74.79%). In addition to Oases assembly, we also used Trinity (k = 25 as a fixed option), SOAP-Trans, ABySS, and the CLC Genomics Workbench www.selleckchem.com/products/cobimetinib-gdc-0973-rg7420.html with default parameters. We also compared
the assembly Dimethyl sulfoxide results by mapping all raw reads onto each assembly, in order to determine the read usage. We obtained the best assembly results from Oases and Trinity, as they showed the largest assembled transcriptome sizes, numbers of mapped reads, average contig lengths, and numbers of TAIR hits (BLASTX; data not shown). For further evaluation of the accuracy of the datasets, we compared both against P. ginseng full-length gene sequences retrieved from GenBank. Large numbers of full-length sequences (including untranslated regions) were found in the Trinity dataset, with 95–100% identity. We found that many truncated transcripts (without the start and stop codons) were included in the Oases dataset. The extracted dataset sequences were also mapped successfully onto our ongoing P. ginseng draft genome sequence assembly using the BLAST algorithm. The Trinity dataset showed more hits and a higher percentage of identity than the Oases dataset, demonstrating that Trinity was the best assembler for our transcriptome assembly. Using Trinity, we obtained 35,527 CP transcripts with an average length of 1,978 bp and 27,716 CS transcripts with an average length of 1,980 bp (Table 1). The lengths of the assembled transcripts ranged from 400 bp to 15,980 bp, with a large number of transcripts in the range of 1,000–2,000 bp in CP as well as in CS.


MK Center: Malvado: Do you play Mortal Kombat games?
Dean Cochran: I used to play the PS2 version a bit but I wasn't very familiar with the characters until I did the show.
MK Center: Malvado: As it was played at flank it Chris Casamassa?
MK Center: Rain: Wchich martial art do you study?
Dean Cochran: I have black belts in Shaolin Kung Fu and Kenpo. I also kickboxed a bit when I was younger training under Benny the Jet.
MK Center: Rain: What are your plans about your future in movies?
Dean Cochran: As an actor you have to take it as it comes, it's a hard road to take. I'd like to do more AMerican television to stay closer to home although I have very much enjoyed the time I spent in Bulgaria playing the lead role in 3 recent action films AIR MARSHAL, SHARK ZONE, and TARGET OF OPPORTUNITY.
MK Center: Rain: How much time do you spend on training everyday?
Dean Cochran: It all depends, if I am shooting a film I train constantly when I'm not on set. If I'm not working then I generally only train in class a couple of times a week at the most and go to the gym on other days.
Dean Cochran: Keep doing them as long as I can. I enjoy the opportunity to share my talent with the world.
MK Center: Rain: Did you enjoy working with Mortal Kombat: Conquest crew?
Dean Cochran: The Florida crew were some of the nicest folks around although they did manage to get me with the old piece of chalk in the altoids container trick. The camera man offered me an altoid and it was actually chalk. It was pretty funny.
MK Center: Rain: Do you still have contacts with someone from the Mortal Kombat: Conquest cast?
Dean Cochran: I talked to Daniel (Siro) a couple of times, he's a great guy. In fact he ended up working with the director who directed me in Air Marshal. Small world.
MK Center: Ghost: Did you fight actually in the serie or someone doubled you?
Dean Cochran: I always do my own fighting in films; however, on the TV show the schedule is so fast that you cannot fight your own fights. The reason is you are shooting another scene in another location while the 2nd unit and stunt crew film fights. Then they send you in to shoot closeups and a couple of kicks at another time.
MK Center: You played only in one episode, this was becuse of scenario ? or maybe other resons?
Dean Cochran: Originally my character was to be a recurring character but I think the producers realized the series was winding down and decided to just make it a one time deal.
MK Center: Did you saw Mortal Kombat Movies ? What do you think about it?
Dean Cochran: I loved the movies.
MK Center: Which part of that episode (in which you played) you like most?
Dean Cochran: I'd have to say it was the off screen time. The cast was terrific and a great group of guys to hang out with. I played some golf with Shau Kahn (excuse my spelling) and hung out with the other guys quite a bit. It was also great shooting on the lot at (I think it was UNiversal in Florida) because I could go to the park for free on my breaks. I even took the Mortal Kombat Conquest tour on a day I was shooting and watched my buddies shoot a scene.
MK Center: Did you maybe heard any rumors about third Mortal Komba Movie?
Dean Cochran: No I haven't.
MK Center: What are youre feelings from Mortal Kombat: Conquest movie plan?
Dean Cochran: The should do it and make me the star.
MK Center: Is Eva Mendes (youre serie wife) so nice in real life like in the serie?
Dean Cochran: Yes she was very nice to work with and is obviously doing very well in her career now.
Dean Cochran: No but I almost stopped there on my last film in Bulgaria. My friend Chuck was working at the American Embassy and invited me over but alas my shooting chedule was extended and I did not have time to fly over to Poland. My buddy tells me it's beautiful.


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text:
Caravans spotted pitched up on popular Nottingham playing fields
The vans were seen pitching up at around 3.30pm on Thursday
Ben ReidSEO writer
Caravans pitch up on Nottingham playing fields
Caravans have been spotted pitched up on a Nottingham playing field.
At least eight vans could be seen on The Meadows playing field, just off from the Victoria Embankment and River Trent.
The playing fields are often a popular spot for games of cricket and football among residents in The Meadows and also popular with dog walkers and visitors to the Embankment.
The caravans were spotted pitching up at around 3.30pm on Thursday, April 29, according to people in the area.
Nottinghamshire Live reported how caravans pitched up in the same spot on June 28 and August 11 last year. On both occasions they were served notice by Nottingham City Council to leave the area.
You can sign up for daily newsletters for Nottinghamshire Live by filling out the form at the top of this story.

redpajama_set_name: RedPajamaCommonCrawl


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Home / Articles / Statistics / When Abuse Turns Deadly
When Abuse Turns Deadly
Having a gun at home increases your risk of being killed by your abuser
Survivors of domestic violence are often told to "just leave," in regards to their abusive partner. If only it could be that simple. Statistics show that the most dangerous time for a survivor of abuse is when she decides to leave an abusive partner.
"Abusers feel like they're losing control that they once had. That's when women are most likely to be killed," says Tami Sullivan, director of family violence research and programs at Yale University.
Women Are Being Killed at Home
Domestic homicide—when a person is killed by a current or former partner— takes the lives of roughly 2,000-3,000 women a year. Women are killed by an intimate partner at twice the rate of men.
While we tend to think of domestic violence as shoving, slapping, punching and other such forms of physical abuse, this is not how most victims of domestic homicide lose their lives. Studies show that female spouses are more likely to be killed with a firearm than all other means combined, and that these women are most often killed at their own home than anywhere else.
Sullivan says that while the homicide rate has been studied, not much research has been done on the correlation between abusers threatening a survivor with a gun and actually following through.
"Women [survivors] will tell you that he cleans his gun in front of her and gets this look that says, 'This is for you.' Or he'll sleep with the gun in the nightstand drawer. Or he'll say, 'I'll kill you if you leave me.' " Clearly, she says, these threats mean something different when the abuser has access to a gun.
Consider a Safety Plan, Not a Weapon
What should a woman do if she suspects or knows her partner is or could be abusive and there's a gun in the home? Should she arm herself, too? The latter question is one Sullivan says she can't answer.
"That needs to be a personal decision." But looking at the research, such as a study by the National Institutes of Health, when a gun was present in the home, the risk of homicide increased more than three times. Additionally, the research showed that a gun in the home was the key factor in escalating nonlethal domestic violence to homicide.
Instead of rushing out to buy a weapon, Sullivan says women should empower themselves in other ways, first, by creating a safety plan. This can be a plan to get help in a dire situation or to escape permanently. "Is there a secret code you can text your friends that lets them know that you feel really unsafe?" asks Sullivan.
"It is critically important that she call a hotline to talk about her options so she can understand what can be useful in her unique situation," says Sullivan. You can contact a domestic violence shelter near you on our help page, most of which have a 24/7 hotline staffed by trained domestic violence advocates. You can also call the National Domestic Violence Hotline at 800-799-SAFE (7233). An advocate can help you safety plan, find shelter and connect you to other services in your area—from legal to financial to educational—all with the intent to give a survivor the tools she needs to get out of a potentially deadly situation safely.
https://www.domesticshelters.org/articles/statistics/when-abuse-turns-deadly
Abuse Almost Always Escalates
Will My Partner Be Violent After I Leave?
Danger Assessment Could Predict if an Abuser Will Kill
Will An Abuser Kill You?
A Deadly Cycle


text:
Reliability of unconventional torso anthropometry using a three-dimensional scanner in peruvian children and adolescents [version 1; peer review: 1 approved with reservations, 1 not approved]
Carlos Alberto Delgado, Roberto Shimabuku, Erika Alarcón, Luis Huicho, Augusto Cesar Ferreira De Moraes
Educadores y educandos en ciencias de la salud y la atención de la salud
© 2018 Delgado CA et al. Background: Three-dimensional (3D) scanners have made it possible to measure and display body surface and shape with high precision. These are fast measurements with minimum discomfort, which is especially useful when children are involved. The objective was to assess the reliability and validity of a 3D-scanner for measuring unconventional torso parameters in children and adolescents. Methods: This is a sub-sample of the SAYCARE study, an observational multicentre research effort being conducted in six South American countries, aimed at developing methods to collect data on cardiovascular health biomarkers, lifestyles, and environmental, social and family risk factors. Images were captured using a portable scanner (iSense, Cubify, USA) attached to a Tablet 128Gb with OSX (Ipad-Air Apple, USA). Images were reshaped to exclude head, hair, arms and legs; area and volume were measured using 3D design software ((Rhinoceros for OSX, v5.02, USA). Results: The sub-sample for our study comprised 54 girls and 46 boys, aged 6 to 17 years old, from two private schools in Lima, Peru. Out of 100 participants, 82 were scanned twice. There was strong reliability (rho_c>0.80) between first and second measurements of area and volume in boys of every age group. In girls, the reliability coefficient was moderate (rho_c>0.70) only for area comparison in adolescents older than 10 years of age. The mean torso area was 0.55 m2 (SD 0.08) in girls and 0.63 m2 (SD 0.13) in boys. The overall mean torso volume was 24.4 l (SD 5.33) in girls and 31.47 l (SD 10.14) in boys. Area under ROC curve oscillates between 0.5707 and 0.6383 when volume/area ratio was compared to the selected "gold standard" (waist to height ratio > 0.5). Conclusion: Use of portable and low cost 3D-scanners provides a reliable but inaccurate alternative for area and volume torso measurements in children and adolescents.
F1000Research
https://doi.org/10.12688/F1000RESEARCH.13936.1
10.12688/F1000RESEARCH.13936.1
Dive into the research topics of 'Reliability of unconventional torso anthropometry using a three-dimensional scanner in peruvian children and adolescents [version 1; peer review: 1 approved with reservations, 1 not approved]'. Together they form a unique fingerprint.
Torso Medicine & Life Sciences 100%
Peer Review Medicine & Life Sciences 96%
Anthropometry Medicine & Life Sciences 93%
Volume Chemical Compounds 44%
Environmental Biomarkers Medicine & Life Sciences 28%
Software Design Medicine & Life Sciences 27%
Waist-Height Ratio Medicine & Life Sciences 27%
Alberto Delgado, C., Shimabuku, R., Alarcón, E., Huicho, L., & De Moraes, A. C. F. (2018). Reliability of unconventional torso anthropometry using a three-dimensional scanner in peruvian children and adolescents [version 1; peer review: 1 approved with reservations, 1 not approved]. F1000Research. https://doi.org/10.12688/F1000RESEARCH.13936.1
Alberto Delgado, Carlos ; Shimabuku, Roberto ; Alarcón, Erika ; Huicho, Luis ; De Moraes, Augusto Cesar Ferreira. / Reliability of unconventional torso anthropometry using a three-dimensional scanner in peruvian children and adolescents [version 1; peer review: 1 approved with reservations, 1 not approved]. In: F1000Research. 2018.
@article{822cd11563534e3c8229776d9aa1f2b3,
title = "Reliability of unconventional torso anthropometry using a three-dimensional scanner in peruvian children and adolescents [version 1; peer review: 1 approved with reservations, 1 not approved]",
abstract = "{\textcopyright} 2018 Delgado CA et al. Background: Three-dimensional (3D) scanners have made it possible to measure and display body surface and shape with high precision. These are fast measurements with minimum discomfort, which is especially useful when children are involved. The objective was to assess the reliability and validity of a 3D-scanner for measuring unconventional torso parameters in children and adolescents. Methods: This is a sub-sample of the SAYCARE study, an observational multicentre research effort being conducted in six South American countries, aimed at developing methods to collect data on cardiovascular health biomarkers, lifestyles, and environmental, social and family risk factors. Images were captured using a portable scanner (iSense, Cubify, USA) attached to a Tablet 128Gb with OSX (Ipad-Air Apple, USA). Images were reshaped to exclude head, hair, arms and legs; area and volume were measured using 3D design software ((Rhinoceros for OSX, v5.02, USA). Results: The sub-sample for our study comprised 54 girls and 46 boys, aged 6 to 17 years old, from two private schools in Lima, Peru. Out of 100 participants, 82 were scanned twice. There was strong reliability (rho_c>0.80) between first and second measurements of area and volume in boys of every age group. In girls, the reliability coefficient was moderate (rho_c>0.70) only for area comparison in adolescents older than 10 years of age. The mean torso area was 0.55 m2 (SD 0.08) in girls and 0.63 m2 (SD 0.13) in boys. The overall mean torso volume was 24.4 l (SD 5.33) in girls and 31.47 l (SD 10.14) in boys. Area under ROC curve oscillates between 0.5707 and 0.6383 when volume/area ratio was compared to the selected "gold standard" (waist to height ratio > 0.5). Conclusion: Use of portable and low cost 3D-scanners provides a reliable but inaccurate alternative for area and volume torso measurements in children and adolescents.",
author = "{Alberto Delgado}, Carlos and Roberto Shimabuku and Erika Alarc{\'o}n and Luis Huicho and {De Moraes}, {Augusto Cesar Ferreira}",
doi = "10.12688/F1000RESEARCH.13936.1",
journal = "F1000Research",
publisher = "F1000 Research Ltd.",
Alberto Delgado, C, Shimabuku, R, Alarcón, E, Huicho, L & De Moraes, ACF 2018, 'Reliability of unconventional torso anthropometry using a three-dimensional scanner in peruvian children and adolescents [version 1; peer review: 1 approved with reservations, 1 not approved]', F1000Research. https://doi.org/10.12688/F1000RESEARCH.13936.1
Reliability of unconventional torso anthropometry using a three-dimensional scanner in peruvian children and adolescents [version 1; peer review: 1 approved with reservations, 1 not approved]. / Alberto Delgado, Carlos; Shimabuku, Roberto; Alarcón, Erika; Huicho, Luis; De Moraes, Augusto Cesar Ferreira.
In: F1000Research, 01.01.2018.
T1 - Reliability of unconventional torso anthropometry using a three-dimensional scanner in peruvian children and adolescents [version 1; peer review: 1 approved with reservations, 1 not approved]
AU - Alberto Delgado, Carlos
AU - Shimabuku, Roberto
AU - Alarcón, Erika
AU - Huicho, Luis
AU - De Moraes, Augusto Cesar Ferreira
N2 - © 2018 Delgado CA et al. Background: Three-dimensional (3D) scanners have made it possible to measure and display body surface and shape with high precision. These are fast measurements with minimum discomfort, which is especially useful when children are involved. The objective was to assess the reliability and validity of a 3D-scanner for measuring unconventional torso parameters in children and adolescents. Methods: This is a sub-sample of the SAYCARE study, an observational multicentre research effort being conducted in six South American countries, aimed at developing methods to collect data on cardiovascular health biomarkers, lifestyles, and environmental, social and family risk factors. Images were captured using a portable scanner (iSense, Cubify, USA) attached to a Tablet 128Gb with OSX (Ipad-Air Apple, USA). Images were reshaped to exclude head, hair, arms and legs; area and volume were measured using 3D design software ((Rhinoceros for OSX, v5.02, USA). Results: The sub-sample for our study comprised 54 girls and 46 boys, aged 6 to 17 years old, from two private schools in Lima, Peru. Out of 100 participants, 82 were scanned twice. There was strong reliability (rho_c>0.80) between first and second measurements of area and volume in boys of every age group. In girls, the reliability coefficient was moderate (rho_c>0.70) only for area comparison in adolescents older than 10 years of age. The mean torso area was 0.55 m2 (SD 0.08) in girls and 0.63 m2 (SD 0.13) in boys. The overall mean torso volume was 24.4 l (SD 5.33) in girls and 31.47 l (SD 10.14) in boys. Area under ROC curve oscillates between 0.5707 and 0.6383 when volume/area ratio was compared to the selected "gold standard" (waist to height ratio > 0.5). Conclusion: Use of portable and low cost 3D-scanners provides a reliable but inaccurate alternative for area and volume torso measurements in children and adolescents.
AB - © 2018 Delgado CA et al. Background: Three-dimensional (3D) scanners have made it possible to measure and display body surface and shape with high precision. These are fast measurements with minimum discomfort, which is especially useful when children are involved. The objective was to assess the reliability and validity of a 3D-scanner for measuring unconventional torso parameters in children and adolescents. Methods: This is a sub-sample of the SAYCARE study, an observational multicentre research effort being conducted in six South American countries, aimed at developing methods to collect data on cardiovascular health biomarkers, lifestyles, and environmental, social and family risk factors. Images were captured using a portable scanner (iSense, Cubify, USA) attached to a Tablet 128Gb with OSX (Ipad-Air Apple, USA). Images were reshaped to exclude head, hair, arms and legs; area and volume were measured using 3D design software ((Rhinoceros for OSX, v5.02, USA). Results: The sub-sample for our study comprised 54 girls and 46 boys, aged 6 to 17 years old, from two private schools in Lima, Peru. Out of 100 participants, 82 were scanned twice. There was strong reliability (rho_c>0.80) between first and second measurements of area and volume in boys of every age group. In girls, the reliability coefficient was moderate (rho_c>0.70) only for area comparison in adolescents older than 10 years of age. The mean torso area was 0.55 m2 (SD 0.08) in girls and 0.63 m2 (SD 0.13) in boys. The overall mean torso volume was 24.4 l (SD 5.33) in girls and 31.47 l (SD 10.14) in boys. Area under ROC curve oscillates between 0.5707 and 0.6383 when volume/area ratio was compared to the selected "gold standard" (waist to height ratio > 0.5). Conclusion: Use of portable and low cost 3D-scanners provides a reliable but inaccurate alternative for area and volume torso measurements in children and adolescents.
U2 - 10.12688/F1000RESEARCH.13936.1
DO - 10.12688/F1000RESEARCH.13936.1
JO - F1000Research
JF - F1000Research
Alberto Delgado C, Shimabuku R, Alarcón E, Huicho L, De Moraes ACF. Reliability of unconventional torso anthropometry using a three-dimensional scanner in peruvian children and adolescents [version 1; peer review: 1 approved with reservations, 1 not approved]. F1000Research. 2018 Jan 1. https://doi.org/10.12688/F1000RESEARCH.13936.1


text:
Benin Expedition 120 years on
Benin Expedition by Rawson
Benin Historical Figures
BPE 1897 >
Oba Overami trial transcript >
BM News >
Signing over the Kingdom, NOT !
Oba Ovonramwem the 36th Oba of Benin was on the throne when the British were getting kingdoms across the West African coast and along the Benin River to sign over their sovereignty to the Queen of England.
The Oba being prudent refused to sign any documents he could not read on the grounds of how was he and his chiefs to know what the paper said and in any case, Benin Kingdom already had a sovereign and good trading relationships across West Africa and with the Europeans.
Judging by the wordings in the treaty example below, it would have been very difficult for any interpreter to accurately translate some of the words from English to Edo or any other local language.
Not only was there a treaty between the absent queen and the local kings and chiefs on behalf of their people, they also had to sign one with the Royal Niger Company. King Ovonramwen the Great smelt a rat and did not cooperate. As we now know they were being duped into surrendering all powers to rule themselves and to control trade in their kingdom. In many cases George Goldie of the Royal Niger Company made up signed treaties for unsuspecting kings and falsely claimed they signed it. Any one of them who was becoming too rich was soon stripped of all opportunity to continue to do so. Savage brutality was meted out to any chief who erred on any of the treaty points.
This brutality and cruelty only diminished with the commencement of the First World War on July 28 1914 when Great Britain needed to divert personnel towards the war efforts.
Those kings gullible enough to have signed the treaties soon realised that they had in fact signed their own banishment warrants. An example was Chief Nana. In the Letter below by Consul General Ralph Moor to the Foreign Office in London in 1894, Nana Olomu the Itsekiri chief promoted later to Governor of Benin River is accused of crimes serious enough for the Foreign Office to sanction his exile from his people and country to the Gold Coast (now Ghana).
Oba Ovonramwen had been correct all along to be cautious and to wait and see the outcomes of the treaty signings with both the Royal Niger Company and the Royal Niger Protectorate by his fellow unsuspecting kings. His good judgement meant that his chiefs did not have to suffer these cruelties which others had to live with. Full credit should be accorded him on this point.
Oba Ovonramwen is also down in the history books as the last king of the Niger River areas to be taken on by the brutal Royal Niger Company headed by George Goldie. They incited events that led to the Benin Massacre of January 4 1897. By May 1897 the writing was already on the wall for the RNC.
Consul General dispatches to Foreign Office 1894 - 1899
Coronation of the Oba of Benin in 2016


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What is the difference between Audio time and Music time?
Audio time ( or "real" time ) is the length and tempo of a performance as executed and recorded. Whereas "music" (BBT, for Bar-Beat-Tick) time is a series of arranging data (notes and rests) that can be executed very quickly, or very slowly, and still be considered the same.
In "music" time, a quarter-note is a quarter note, regardless of tempo. MIDI consists only of arrangement data, and so it is possible to arrange a MIDI sequence and later increase or decrease the tempo. Just like musicians playing from a score, the arrangement's tempo will increase, but the musical expression and timbre will remain largely unchanged.
When recording audio, the performers are recorded in real-time subject to the players' own tempo and interpretation of the music. And once recorded, you cannot easily change the tempo of the recording. Once audio is recorded, it requires quite extensive processing and manipulation to change the tempo … and even more so if you don't want the pitch to change as well ( i.e. the "chipmunk" effect )
The problem is that Mixbus (and other DAWs) are expected to show both MIDI and Audio data on the same timeline. And there's some ambiguity: one can imagine audio data (such as a single drum hit) that has no inherent tempo, and can be considered arrangement data, and subject to tempo changes in the musical timeline; or one can imagine a MIDI event that is related to the audio timeline and should not move if (for example) the tempo is changed.
Why is this so hard?
Attempting to shorten or lengthen an audio performance, after it is recorded, requires the sound to be digitally manipulated which will incur some loss of quality. Because Mixbus is intended for high-quality editing, mixing, and mastering tasks, we have chosen to give priority to the "audio" timeline. But there are equally valid reasons why a user might be more interested in the "music" time, and so both music and audio-timelines must coexist.
Consider these examples:
A live performance is recorded, and the musicians have varied widely in tempo and meter. The user would like to develop a "grid" which follows the varying tempo, and allows editing to the "grid", just as if the performance were recorded strictly to a metronome. Or perhaps the user would like to add MIDI arrangement using a musical score editor, and these notes must somehow be synced to the performance's tempo.
A MIDI performance is generated with a fixed tempo. Later, a vocal and instrumental tracks are added to the MIDI arrangement, and these tracks are edited with crossfades to assemble the best-sounding mix. Now the arranger would like to gradually decrease the tempo at the end of the song ( i.e. ritardando ). The MIDI events, being tied to the Music timeline, will stretch farther apart, but will stay in tune. But what will become of the audio regions?
A session which mixes spoken-word sections with musical sections. During a musical portion (implemented with MIDI), the tempo is increased, so the musical portion finishes faster than it did, when the audio was recorded. Should the audio voiceover move left to accommodate the shorter musical segment?
Mixbus has some mechanisms to accommodate these situations. But it can get quite complicated.
We have chosen to focus our efforts on the "audio" timeline, rather than the "music" timeline, which is more common among those workstations that began as MIDI sequencers.
How do you use Audio Time and Musical Time?
Every item on the timeline ( regions, markers, and automation control points ) must be either connected to the "audio" timeline, or the music timeline. If an item is attached to the musical timeline, then any changes to the BBT (bar-beat-tick) timeline will be moved along with the musical timeline. For example, if you increase the tempo then the regions will move to occur earlier.
If you are assembling "samples" of a kick drum alongside MIDI-sequences, then it is appropriate to attach the regions to the musical timeline.
What are the default settings for the different timelines?
By default, audio regions use the audio timeline. You can right-click on an audio region to "glue" it to the BBT musical timeline.
By default, MIDI regions are "glued" to the BBT timeline, while audio regions are not. You can right-click on an audio region (or selection of region) to "glue" it to the BBT musical timeline.
Tempo markers are glued to the BBT timeline by default, but they may be unglued (and therefore attached to the audio timeline), by right-clicking on them.
Automation control points are attached to the audio timeline, and cannot (currently) be changed.
Known issues.
Currently, even if a MIDI region is attached to the audio timeline, and it won't move when the tempo map is moved; its CONTENTS will still stretch. That is not desired, so we will likely fix it in a future version.
This is complicated stuff. Investigating other DAW manuals and videos will reveal that there are no easy, non-destructive ways to solve these issues.
So what is the preferred workflow for managing a project that uses both the audio and BBT timelines?
Generally speaking, Mixbus is optimized to work in one of these 2 ways:
1) Record a live performance on the audio timeline, (optionally) map the tempo, and then record MIDI instruments, but never move the tempo/BBT-map after you've started adding MIDI.
2) Arrange your song in MIDI, and adjust tempos/timeline as needed. Then record audio, and never again move the tempo/BBT-map after you've started recording audio.


I received some help today from a colleague today regarding a couple blog and twitter. During our conversation I was able to reciprocate and share a little wisdom of my own. Both of us gained valuable information and were able to help someone else. Usually I think the latter is more important.
In your job search – while things seem pretty tough and even feel out of control, it is helpful yourself to pull yourself away from yourself for a while.
Focusing on other peoples problems such as those looking for work or in some kind of need, is good for your soul.
It let's you feel good about yourself by helping someone else and it takes away your problems, even if just temporarily. God says, help others and I'll help you, cast your cares; sometimes easier said than done. Letting go of the problems doesn't make them go away – it just gives you a little break from them, and that is a good thing!
How can you as a job seeker easily help others? If you hear of a job that might not fit you – pass it along to someone else. If you find a great site online that offers job seekers awesome resources, ideas, and hope – share it! I've heard Joyce Meyer say many times that we are meant to be channels not reservoirs. Share and pass along your knowledge, time and support with others looking for work and I promise someone will help you too.
P.S. See how many job seekers you can help today!


The Mars Society is pleased to announce that Dr. Robert Pappalardo, a Project Scientist in JPL's Planetary Science Division, will provide an update about NASA's Europa Clipper mission during the 20th Annual International Mars Society Convention, scheduled for September 7-10, 2017 at the University of California Irvine.
Due for launch in the 2020's, the Europa Clipper mission will place a spacecraft in orbit around Jupiter in order to perform a detailed investigation of the giant planet's moon Europa - a world that shows strong evidence for an ocean of liquid water beneath its icy crust and which could host conditions favorable for life.
Dr. Pappalardo's research focuses on processes that have shaped the icy satellite moons of the outer solar system, especially Europa, the nature, origin and evolution of bright grooved terrain on Jupiter's moon Ganymede and the geological implications of geyser-like activity on Saturn's moon Enceladus. Prior to joining JPL in 2006, Dr. Pappalardo served as an Assistant Professor of Planetary Science at the University of Colorado Boulder's Astrophysical & Planetary Science Department.
For more details about the 2017 Mars Society Convention, including registration information for the four-day convention and evening banquet, please visit our web site (www.marssociety.org). The full 2017 speaker schedule will be posted online in the near future.


text:
Roadtests
HomeNews 2019 November Aston Martin reveals DBX SUV
Aston Martin reveals DBX SUV 20 | 11 | 2019
SIX MONTHS AFTER being sworn to secrecy, we can now reveal the first official images, specs and prices of the all-new £158,000 Aston Martin DBX. Those of us attending the Guild of Motoring Writers AGM were given exclusive access to the production-ready car at Aston's Gaydon HQ back in May, on the condition we didn't reveal any details. Such was the secrecy that our mobile phones/cameras were taken from us. (Related: Scots Aston Martin dealer is World No1)
And if you think the car looks good in the photographs, the DBX is even better in the metal. Speaking with Marek Reichman, Aston Martin's chief creative officer at the event, I asked him about the car's design.
"The DBX had to look dynamic, look lithe, because this is a car that has to perform on a dynamic level but also a luxury level," he explained. "I said to the designers, 'This is not a bread van. It sits somewhere between a coupé and something like a Mk4 Discovery.' We wanted to show our car's sporting capability visually.
"I'm 6ft 4in and I told the team, 'I want to be able to sit behind myself in this car.' And I can."
Under development since 2015, the DBX goes head-to-head with the likes of the Lamborghini Urus, Porsche Cayenne Turbo and Bentley Bentayga. And while more than 70% of current Aston owners already have an SUV tucked away in their garages, the company also believes the DBX will attract more female buyers to the marque. (Related: 715bhp DBS Superleggera Volante)
Measuring just over five metres long and 2.2 metres wide, including side mirrors, the new SUV is based on an aluminium construction. That said, the DBX does also benefit from its own unique architecture, which sets it apart from the rest of the line-up. The use of composite panels also help keep weight down to just over 2.2 tonnes. (Related: All-electric 602bhp Aston Martin Rapide E)
Aesthetically, in the metal the car certainly looks more sportscar than SUV. A high-rise, slab-sided behemoth this is not. Its lines are sleek and sensual, yet powerful and imposing. This is a car which will be capable of crossing countries with a relaxed ease.
The long bonnet glides its way back from what is the largest front grille Aston has ever made in its 106-year history. With a smile, Reichman stated: "I didn't want it to be mistaken for anything other than one of our cars. This is one of our core models. We've stopped being just a sports car manufacturer."
From the side, the DBX displays relatively short overhangs and a cabin which is well set back from the grille. And the clever use of guidelines create an illusion which makes the roofline look more sharply raked than it really is. (Related: Aston Martin Valkyrie targets LM24 win)
From the rear, the DBX's stylish looks are further emphasised by the designers' decision to taper the bodywork in noticeably beyond the rear wheels. Not only does this aid the car's aerodynamics, but it further removes any thought of slabbiness.
Engine and specs
Power for the new DBX comes from a retuned version of the Mercedes-AMG-sourced 4.0-litre twin-turbo V8 petrol engine used in the Vantage and DB11. Delivering 542bhp and 700Nm of torque, it'll propel the car from standstill to 62mph in 4.5 seconds and to a top speed of 181mph.
The power is delivered to all four wheels a nine-speed torque-converter automatic gearbox. The 4WD system incorporates an active centre differential and an e-diff at the rear, which allows torque to be split front to rear, ranging from a 47:53 split, to almost entirely rear-drive. Turn-in is further aided by vector torque generated by the brakes.
Aston says fuel consumption will be just under 20mpg (WLTP), with CO2 emissions of 269g/km.
Though nothing has been confirmed yet, there is the possibility of a plug-in hybrid version, as the DBX's platform has been engineered to accept the technology. That, of course, will be crucial in attracting buyers in cites which will inevitably outlaw cars with no pure-electric capacity.
As for offroad ability, Reichman focused o the DBX being able to at least match the capabilities of the likes of the Cayenne or Bentayga. Ok, so it's not Range Rover ability, but it will be capable of far more than any owner is likely to consider putting his, or her £158,000 DBX through. And as an indication, it will be capable of towing more than 2.5 tonnes or driving through half a metre of water.
Approach and departure angles are 22.2 degrees and 24.3 degrees respectively (25.7 degrees and 27.1 degrees is the car is raised on its air suspension), and the maximum wading depth is exactly 500mm.
That air suspension has four settings, and is paired with a 48-volt anti-roll system. That, according to Aston martin, means the DBX, with the air suspension in its most aggressive setting, will have a body roll comparable with that of the DB11 GT.
Interior and tech
Inside, it's no surprise the DBX is the most practical Aston ever. Yes there's room for five adults, plus there a pair of Isofix points in the rear, but the bootspace cannot only swallow an impressive 632 litres, but there's an extra 62 litres below the boot floor. Rear seats fold 40:20:40, and the car can lower itself by 50mm so it's easier to load heavy items.
The designers have also ensured the rear doors have a minimal intrusion from the rear wheelarches, making it easier to get in and out. Naturally, tis also makes it easier to install or remove a child seat or baby chair.
Aston's Q personalisation service will also include a luxurious four-seater version, which will allow the space between the rear seats to be used for everything from champagne fridges to cigar boxes … as you do.
Up front, the DBX gets an al-new version of Aston's infotainment system, developed with Daimler. Not only is there a 12.3-inch digital instrument cluster, but there's also a 10.25-inch central infotainment display neatly integrated into the fascia.
And while the 800-watt sound system is sure to have your ears ringing, the DBX comes with Apple CarPlay as standard, plus there's USB sockets front and rear. In addition to ambient lighting with a choice of 64 colours, there's also a three-zone climate control system
To be built at the new Aton Martin facility at St Athan in Wales, the DBX starts at £158,000; which is around the same as the Urus. Available to order now, first customers can expect delivery in Spring 2020.
Related: Aston Martin SUV starts testing
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Jim McGill
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text:
LC Helms
Writer of Fiction, Non Fiction and Short Stories
ABOUT LC HELMS
AUTHOR SPOTLIGHT DR. SAM WRIGHT
LC's Book Recommendations
The Night Child by Anna Quinn
Anna Quinn fearlessly takes the reader on a journey through Nora Brown's dilemmas and discoveries as this English teacher and mother suddenly plunges into darkness when she begins to see an apparition of a young child. Unsure of what is happening to her, she seeks professional help. A secret emerges and Nora begins to relive early unresolved childhood trauma. It's a story of hope and resilience despite powerful odds. Will Nora spiral into darkness and lose herself in the trauma of the past or will she bravely re-enter that darkness in search of truth and wholeness?
Enter Nora's world and follow her on a journey to find answers. But can she handle the truth without breaking apart and losing everything? As a mental health counselor, I find that true healing requires taking a quest and a long journey back through the darkness to find hope and regeneration, but only when we're ready and we have the proper road mad to get there. There is always hope if one is determined and brave enough to allow others to walk alongside as they pursue wholeness.
Home Safe by Elizabeth Berg
Home Safe is a richly written story of the complexities of life, family and relationships. Yet, through this story's mix of transition and grief, turmoil, twists, and this character's surprising discoveries, Berg sprinkles in lots of comfort, hope, and courage.
Helen Ames, a writer struggling with grief and writer's block, is shocked when she finds out that a huge chunk of her family's life savings is missing, and her husband isn't alive to question.
Forced to deal with issues she's long been avoiding, she embarks on an emotional journey toward wholeness and change. Will her discoveries tear apart her relationship with her daughter or draw them closer and allow her to move on with her life?
Find out for yourself in this humorously witty and well-written story by the beloved writer, Elizabeth Berg.
The Last Draft by Sandra Scofield
This is a non-fiction how to guide for writers who are editing their completed novel, short story, or wanting to revise their work. Sandra takes the writer through the editing and revision process step by step with wonderful assignments and tools that will make your manuscript sparkle. She provides priceless tools for your writer's toolbox that you can utilize again and again.
Even if you don't have a finished manuscript, reading her book will improve your writing. Sandra is also the author of The Scene Book. These books are priceless and ones every writer must have in their toolbox.
Buried Secrets by Irene Hannon
In book one of the Men of Valor series, ex-Navy SEAL, Mac Macgregor works with police chief Lisa Grant to solve a mystery when a construction crew finds, not a body, but a skeleton in an unmarked grave. Romance and danger surround Macgregor and Grant as they work to solve the strange case, and someone will stop at nothing to keep these secrets buried.
This mystery-suspense will grab onto you and keep you reading until the last clue is revealed. Check out Irene Hannon's website and take a peek at the other books in this series. (Thin Ice and Tangled Webs). I recommend this inspirational suspense if you like mystery, intrigue, and romance. Hannon does it again.
Redeeming Love by Francine Rivers
If you've ever read the biblical story of Hosea and his dedicated pursuit and love for Gomer, and you also enjoy reading books within the time period of the late 1800's and the California Goldrush, you'll love this novel. I recommend this book for its message of hope , long-suffering, and unconditional love. Rivers' writes with a unique style and is able to take us into the hearts and minds of each character and awaken our feelings as we cheer them on. I thoroughly enjoyed this novel.
Exciting news from the publisher! Two new Redeeming Love products this fall. One a devotional titled A Path to Redeeming Love and the other a companion study guide to Redeeming Love. They will release on Oct. 30th 2020.
© 2020 by LC Helms Author


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Education news, analysis, and opinion about students' ability to use technology to discover, evaluate, and utilize information
What Is Digital Literacy?
For educators, digital literacy means much more than learning to read online. Here's a guide to understanding it.
View Explainer
Teacher Preparation English Teachers Must Be Anti-Racist, National Group Says
The long-awaited standards from the National Council of Teachers of English emphasize teacher training in anti-racism and digital media.
Madeline Will, November 10, 2021
Privacy & Security Spotlight Spotlight on Cybersecurity
This Spotlight will empower educators to begin identifying the next generation of tech leaders, and more.
Teaching Quiz Quiz Yourself: How Much Do You Know About Data Literacy
Quiz Yourself: How much do you know about data literacy?
Content provided by Federal Reserve Bank of St. Louis
Tue., April 20, 2021, 2:00 p.m. - 3:00 p.m. ET
School & District Management Webinar Making Digital Literacy a Priority: An Administrator's Perspective
Join us as we delve into the efforts of our panelists and their initiatives to make digital skills a "must have" for their district. We'll discuss with district leadership how they have kept digital literacy
Content provided by Learning.com
Classroom Technology Opinion The Stanford Scholar Bent on Helping Digital Readers Spot Fake News
Rick Hess speaks with Sam Wineburg about fake news, digital learning, and how to help children navigate online content.
Rick Hess, April 8, 2021
Thu., January 21, 2021, 2:00 p.m. - 3:02 p.m. ET
Future of Work Webinar Digital Literacy Strategies to Promote Equity
Our new world has only increased our students' dependence on technology. This makes digital literacy no longer a "nice to have" but a "need to have." How do we ensure that every student can navigate
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Classroom Technology Opinion Digital Citizenship Is About a Whole Lot More Than Online Etiquette
It's time to abandon our focus on technology etiquette and turn to online ethics instead, writes Michelle Ciccone.
Michelle Ciccone, August 20, 2020
Reading & Literacy With New Anti-Plagiarism Tool, Google Enters Familiar Debates About Teaching Writing
Will teachers use the "originality reports" added to Google's popular Classroom platform to target cheaters—or tee up teachable moments about fair use and proper citation?
Benjamin Herold, August 22, 2019
Classroom Technology From Data Security to Digital Literacy: The 5 Toughest Tasks for One CTO
Rob Dickson, the executive director of information management services for the Omaha Public Schools, outlines his biggest challenges and lessons learned from this school year.
Alyson Klein, June 11, 2019
From left, sixth graders Maryann Hernandez, Fynn Gullicks, Kylie Duchsherer, and Sa'Rai Ridley work on an anti-bullying video at Horizon Middle School.
Kristina Barker for Education Week
Future of Work Photos What Does Digital Literacy Look Like in North Dakota?
Schools are doing more to incorporate technology and cyber security into their teacher training and student curriculum.
Education Week Photo Staff, April 3, 2019
Reading & Literacy Video Experience Education Week's Summit on "Literacy for the Workplace"
Assistant Managing Editor Debra Viadero talks about the gap between expectations and reality when it comes to the kinds of literacy skills students need for an ever-changing workplace and invites educators to take part in the "Literacy for the Workplace" summit on Tuesday, February 19, at 1 p.m. In this online event, Education Week journalists and guests will staff online "discussion rooms" on a host of topics, including: how speaking skills are rising in prominence; the need for digital literacy; and writing skills that go beyond the five-paragraph essay. You will get a unique opportunity to interact directly with the writers and experts who helped shape coverage of our new special report on workplace literacy. After the discussions, watch writers and editors sum up the discussions in a series of livestreamed interviews.
Curriculum FUNecole: Social-Emotional Learning Meets Computer Science and Digital Literacy
FUNecole, an online learning platform and curriculum from a European-based company, combines social-emotional learning with computer science. It's used in multiple European countries, and might be coming to U.S. schools.
Lauraine Genota, November 9, 2018
Special Report Literacy for the Workplace
The modern workplace is evolving and employers say that students need different kinds of literacy skills in order to thrive in it. Will English classes change in response?
Bobbie Wells wipes down a bedside tray in a hospital room in the Christiana Care Health System. Wells and her co-workers use a high-tech, ultraviolet-light cleaning system, which is digitally operated and requires extensive training.
Nate Pesce for Education Week
College & Workforce Readiness Jobs at All Levels Now Require Digital Literacy. Here's Proof.
Education Week visited Delaware's largest employer for a closer look at how digitization is changing the workplace.
Benjamin Herold, September 25, 2018


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Babaee, Sima, MSc, Department of Medical Surgical Nursing, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan
Babaee, Sima, MSc, Department of Medical Surgical Nursing, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.
Babaee, Sima, MSc, Department of Medical Surgical Nursing, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran (Iran, Islamic Republic of)
Babaee, Sima, Nursing and Midwifery Care Research Center, Faculty of Nursing and Midwifery, Isfahan, Iran
Babaee, Sima, Department of Adult Health Nursing, Intensive Care Nursing, Faculty of Nursing and Midwifery, Isfahan University of medical sciences, Isfahan, Iran
Babaee, Sima, MSc, Department of Surgery, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.
Babaei, Amir Hossein
Babaei, Elaheh, MSc Student, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.
Babaei, Sima, MSc, Department of Medical Surgical Nursing, School of Nursing and Midwifery, Isfahan University of Medical Sciences,Isfahan,Iran
Babaei, Sima, Adult Health Nursing Department, Faculty of Nursing and Midwifery, Nursing and Midwifery Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Babaei, Sima, * MSc, Department of Medical Surgical Nursing, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.
Babaei, Sima, Instructor of Medical - Surgical Nursing, Medical - Surgical Nursing Department, School of Nursing & Midwifery, Isfahan university of Medical Sciences, Isfahan (Iran, Islamic Republic of)
Babaei, Sima, Student Department of Adult Health Nursing, Nursing and Midwifery Care research center, Faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran
Babaei, Sima, Instructor of Medical – Surgical Nursing, Department of Medical - Surgical Nursing, School of Nursing and Midwifery, Isfahan university of Medical Sciences
Babaeipour‑Divshali, Mohammad, Department of Operating Room, Langrud Faculty of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran,
Babaie, Zohre, Student Research Center, Faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran
Babashahabi, Ronak
Babashahi, Monireh, MSc, Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Islamic Azad University, Najafabad Branch, Isfahan, Iran.
Babazadeh, Shadi, MD, Assistant Professor, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Babazadeh, Shadi, MD, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Badiee, Zohreh
Badiee, Zohreh, Child Growth and Development Center, Isfahan University of Medical Sciences, Isfahan, Iran (Iran, Islamic Republic of)
Badiee, Zohreh, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Badiee‑Aval, Shapour, Department of Acupuncture, School of Traditional Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Badii, Zohreh, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
Badrali, Narges, BSc Student, Student Research Committee, School of Nursing and Midwifery, Medical Students Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Baghban, Iran, PhD, Department of Counseling, Faculty of Education and Psychology, Isfahan University, Isfahan, Iran.
Bagheri, AhmadReza, Department of Cardiology, Clinical Research Development Center, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran
Bagheri, Maryam, Department of Adult Health Nursing, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran
Bagheri, Maryam
Bagheri- Lankarani, Narges, Department of Medical Ethics,Royan Institute, Tehran, Iran,
Bagheriyan, Samaneh, MSc in Nursing, School of Nursing and Midwifery, Bam branch, International University, Kerman, Iran.
Bagheri‑Nesami, Masoumeh
Baghersad, Zahra, Student Research Center, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran
Baghersad, Zahra, Student Research Committee, School of Nursing and Midwifery, Isfahan University of Medical Science, Isfahan, Iran
Baghersad, Zahra, Nursing and Midwifery Care Research Center, Department of Midwifery and Reproductive Health, Faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran
Baghestani, AhmadReza, Department for Biostatistic, School of Paramedicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Baghestani, AhmadReza, Department of Biostatistics, Physiotherapy Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Baghiani Moghadam, Mohammad Hosein, PhD, Associate Professor, Health Education, School of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Baghiani Moghadam, Mohammad Hossein, Department of Health, Azad University of Firoozabad Branch, Fars
Baghlani, Rouya, Department of Pediatric Nursing, Student Research Committee, School of Nursing and Midwifery, Tabriz, Iran,
Bahadoran, B, MSc Department of Midwifery, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran
Bahadoran, Parvin, MSc, Department of Midwifery, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran
Bahadoran, Parvin, Nursing and Midwifery Research Center, School of Nursing and Midwifery, Isfahan University of Medical Science, Isfahan, Iran
Bahadoran, Parvin, Ms of Midwifery, School of Nursing and Midwifery, Isfahan university of Medical Sciences, Isfahan
Bahadoran, Parvin, MSc, Department of Midwifery, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan
Bahadoran, Parvin, Nursing and Midwifery Care Research Center, Faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran
Bahadoran, Parvin, Ms of Midwifery, School of Nursing and Midwifery, Isfahan university of Medical Sciences, Isfahan, Iran Pediatric Nursing
Bahadoran, Parvin, MSc, Department of Midwifery, School of Nursing & Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran
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Another day, another gorgeous ancient Spanish city, another stunning landmark building turned into a clever, stylish little boutique hotel. Not that we're complaining. The Hotel Rector in Salamanca is the sort of thing that keeps one coming back again and again. You can only do the major capitals so many times before a certain sameness sets in — a wealth of attractions in secondary and tertiary markets is what makes Spain a perennial destination (see also: Italy).
Enough abstraction. The Rector, after all, is remarkable not for what it represents, but for its specific physical charms. An object, not a concept. It's located within the old town, which is a must in this picturesque city, and it's a marvelous aristocratic residence, converted into a hotel of just thirteen rooms. And while the building itself has been quite well preserved, the interiors have kept pace with the times — in the rooms you'll find a contemporary, if rather conservative, luxury-boutique look.
At this scale it just wouldn't pay to throw in a three-star restaurant and an indoor pool. High-maintenance guests might opt for a more traditional business hotel. But with anyone who's got an eye towards an idiosyncratic and quietly chic experience in old-town Salamanca, the Rector is an easy choice.
Hotel Rector can be reached from Salamanca Airport(SLM) in approximately 20 minutes by car; from the central rail station it takes just 5 minutes. Driving to Hotel Rector from Madrid is a 2.5 hours trip, from Valladolid 1.5 hours. Please contact CustomerService@TabletHotels.com for assistance with airport/rail station transfers.