text:
Richmond Park, London
Richmond Park is a 955 hectares (9.55 km2; 3.69 sq mi)[1] urban park within London. Almost three times as large as New York City's Central Park,[2] it is Britain's largest urban walled park, and the largest of the Royal Parks in London. It is close to Richmond, Ham, Kingston upon Thames, Wimbledon, Roehampton and East Sheen.[2] The park is famous for its red and fallow deer, which number over six hundred.
1 Significant features
1.1 King Henry VIII's Mound
2 Plantings
3 Wildlife
6 Constituency
Significant features
The Isabella Plantation is an important and attractive woodland garden.
There is a protected view of St Paul's Cathedral from King Henry VIII's Mound, and a view of the central London's London Eye, Natwest Tower and 'The Gherkin', appearing to be in close proximity to each other.
The Park contains notable buildings, ten of which, plus the whole wall of the park, are listed buildings.
Pembroke Lodge and some associated houses stand in their own garden within the park. Pembroke Lodge was originally a home of 1st Earl Russell, and is now a restaurant.
The Royal Ballet School has been based for many years at White Lodge where younger ballet students continue to be trained. It was originally a hunting lodge for George I.
There are four other houses, apart from the gate-houses: Thatched House Lodge, Holly Lodge (formerly Bog Lodge), White Ash Lodge and Oak Lodge. Holly Lodge contains a visitors' centre (bookings only), the Park's administrative headquarters and a base for the Metropolitan Police's Royal Parks Operational Command Unit.
King Henry VIII's Mound
Looking west from King Henry's Mound.
St Paul's from King Henry's Mound
King Henry VIII's Mound is the highest point within the park and is located within the public gardens of Pembroke Lodge. It is named after Henry VIII of England.
There is speculation that the mound has an older history, and may have originally been a barrow.
From the Mound there is a protected view of St Paul's Cathedral in the City of London over 10 miles (16 km) to the east which was established in 1710. (A telescope is installed on the mound, for a better viewing experience.) This vista is protected by a 'dome and half' width of sky on either side. The Mayor of London (Ken Livingstone) sought to overturn this protection in 2005, and reduce it to 'half a dome'. No final decision is yet public. To the west is a panorama of the Thames Valley.
Plantings
The park's open slopes and woods are based on lowland acid soils. The grassland is mostly managed by grazing. The park contains numerous woods and copses, some created with donations from members of the public.
One such area is the Isabella Plantation, a stunning woodland garden which was created after World War II from an existing woodland, and is organically run, resulting in a rich flora and fauna. It is a major visitor attraction in its own right.
Another is Queen Mother's Copse, a small triangular enclosure on the woodland hill halfway between Robin Hood Gate and Ham Gate, established in memory of the late Queen Elizabeth, the Queen Mother.
Another is Two Storms Wood, a short distance into the park from Sheen Gate. (Some extremely old trees can be seen inside this enclosure).
Another is Bone Copse which was named in 2005. It was started by the Bone family in 1988 by purchasing and planting a tree from the Park authorities in memory of Bessie Bone who died in that year. Trees have been added annually, and in 1994 her husband Frederick Bone also died. The annual planting has been continued by their children.
Deer in Richmond Park, October 2005
Richmond Park is a Site of Special Scientific Interest, a National Nature Reserve and a Special Area of Conservation for the Stag beetle.
Herds of red and fallow deer roam freely within much of the park. A cull takes place each November to ensure numbers can be sustained.
Many of the deer in Richmond Park are infected with a bacterium called Borrelia burgdorferi which can be transmitted to humans through a tic bite causing Lyme disease. Borrelia burgdorferi belong to a group of bacteria known as spirochetes which cause a number of diseases worldwide, including syphilis, leptospirosis, relapsing fever and Lyme disease.
It is an important refuge for other wildlife, including woodpeckers, squirrels, rabbits, stag beetles, insects plus numerous ancient trees, and varieties of fungi.
Richmond Park supports a large population of what are believed to be Ring-necked (or Rose-ringed) Parakeets. These bred from birds that escaped or were freed from captivity.
Pembroke Lodge
During King Edward's (1272–1307) reign the area was known as the Manor of Sheen. The name was changed to Richmond during Henry VII's reign. In 1625 Charles I brought his court to Richmond Palace to escape the plague in London and turned it into a park for red and fallow deer. His decision, in 1637, to enclose the land was not popular with the local residents, but he did allow pedestrians the right of way. To this day the walls remain, although they have been partially rebuilt and reinforced, and Richmond remains the smallest National Park in the UK.
In 1847 Pembroke Lodge became the home of the then Prime Minister, Lord John Russell and was later the childhood home of his grandson, Bertrand Russell. It is now a popular restaurant with glorious views across the Thames Valley.
All houses backing on to the park pay a feudal fee known euphemistically as "Richmond Park Freebord" ranging from about £2 to £200 per annum.
The park is enclosed by a high wall with several gates. The gates either allow pedestrian access only, or allow both vehicular and pedestrian access. The gates for vehicular access are open only during daylight hours, and the speed limit is 20 mph. No commercial vehicles apart from taxis are allowed.[3]
The gates open to motor traffic are: Sheen Gate, Richmond Gate, Ham Gate, Kingston Gate, and Roehampton Gate. Robin Hood Gate (close to the Robin Hood roundabout on the A3) was closed in 2003 as part of a traffic reduction trial and will stay permanently closed.[4]
There is pedestrian access to the park 24 hours a day except when there is a deer cull. This means it is not uncommon to find cyclists, walkers and runners using the park at all times of the day and night. During the deer cull the majority of the gates are locked and warning signs are displayed forbidding access to the park under the orders of The Secretary of State. Warning signs are normally displayed a month before the deer cull occurs.
The park has designated bridleways and cycle paths. These are shown on maps and noticeboards displayed near the main entrances, along with other regulations that govern use of the park.
The bridleways are special in that they are for horses (and their riders) only and not open to other users like normal bridleways. This is rarely a problem as the sandy surface discourages anyone not on horseback. Most riding is done through organized stables which, in general, obey the rules about where they can ride.
The 1997 law limits cycling to: (a) main roads; (b) the hard yellow cycle path that runs around the park (Tamsin Trail); and (c) other hard (i.e. concrete or cement) surfaces. Cycling along the park's mud paths is forbidden as contrary to the park's bye-laws.[3]
Until 2005 the park was policed by the separate Royal Parks Constabulary but that has now been subsumed into the Royal Parks Operational Command Unit of the Metropolitan Police.[5] In recent years the mounted policemen have been replaced by a patrol team in a four-wheel drive vehicle.
Most users respect the rules, but there are occasional abuses. The most frequent offenders are motorists and speed cyclists who fail to observe the 20 mph limit. At busy times motorists can be seen parking outside the designated car parks or driving off the roads. Recreational cyclists can be a problem: some mountain bikers are tempted to ride away from the designated cycle paths.
As with other Royal Parks, the use of barbecues and the lighting of other fires is illegal.[6] The playing of radios or other musical equipment is also not allowed. Commercial photography requires permission.
The park has disabled access[7] and many of the gates have toilet facilities next to them. There is also a children's playground next to Petersham Pedestrian gate.
As the park is an area of special scientific interest and a Nature Reserve, all dog owners are required to keep their dogs under control while in the park. This includes not allowing their dog to disturb other park users or disrupt wildlife[8] Unfortunately some dog owners have allowed their animals to disturb wildlife leading to the death of wild fowl, so from 2009 the park's dogs on leads policy has been extended.[9] It is also common to come across dog owners and dogs playing with dead wood. Dog owners have been asked not to do this as this wood has been purposely left for the park's beetles.[10]
Main article: Richmond Park (UK Parliament constituency)
Richmond Park is also the name of a Parliamentary constituency comprising some of the districts that surround the park:
The Electoral Wards of Barnes, East Sheen, Ham & Petersham, Kew, Mortlake, North Richmond and South Richmond in the London Borough of Richmond upon Thames;
the Wards of Canbury, Coombe Hill, Coombe Vale and Tudor in the Royal Borough of Kingston upon Thames.
The present MP is Susan Kramer, a Liberal Democrat.
Where is Richmond Park located ?
Download the map here - http://www.royalparks.org.uk/parks/richmond_park/
Sawyer's Hill, Richmond, Greater London TW10 5, UK
* approximate times
Area served: -
Unverified listing
Opening Times of Richmond park, london
The park is open from 7am in the summer and 7.30am in the winter, and closes at dusk all year round. A document giving specific opening and closing times for the whole year can be downloaded here.
Main attractions at Richmond park, london
Richmond Park, originally a deer-hunting park, still has 300 Red Deer and 350 fallow deer. The deer have played a major role in the Park's history and have shaped the landscape too. Our special grassland habitat depends on grazing and the parkland trees have a distinctive 'browse line' as the deer eat all the leaves and twigs growing below about 1.5 metres. Deer grazing also prevents tree seedlings from growing, keeping the grassland open. For young trees to survive they need to be protected against damage from deer antlers for some 50 years.
During the autumn the deer 'rut' (breeding season) takes place. The red stags and fallow bucks compete for females (known as hinds and does respectively). At this time, the large males roar, bark and clash antlers in a spectacular way in an attempt to fight off rivals and to attract as many females as possible. The young are born mainly in June, and are hidden by their mothers amongst the bracken and long grass. Females and their young are very vulnerable and sensitive to disturbance at this time.
The deer are wild animals, so never try to touch or feed them. Always keep a respectful distance, especially if you have a dog.
Deer in other Parks
Isabella Plantation - a garden for all seasons
The Isabella Plantation is now an ornamental woodland garden, full of exotic plants, that is designed to be interesting all year round. But its name suggests a far humbler origin.
In the 17 th century, this area in the south west corner of Richmond Park was known as The Sleyt. This is the name usually used for boggy ground or an open space between woods or banks.
By 1771, it is shown on maps as Isabella Slade . Isabella may have been the wife or daughter of a member of staff. But it is more likely to be a corruption of the word isabel, which was used as far back as the 15th century to mean dingy or greyish yellow - the colour of the soil in this part of the park.
In 1831, Lord Sidmouth, the park deputy ranger, fenced off 17ha (42 acres) of the Isabella Slade . He planted oak, beech and sweet chestnut trees as a crop for timber and gave the area the name it has today.
The present garden of clearings, ponds and streams was established from the 1950s onwards. It is largely the work of George Thomson , the park superintendent from 1951-1971. Along with his head gardener, Wally Miller, he removed Rhododendron ponticum from large areas and replaced it with other rhododendron species. They established evergreen Kurume Azaleas around the Still Pond and planted other exotic shrub and tree species. The main stream through the garden from Broomfield Gate was dug in 1960 and the plantation was enlarged to include Peg's Pond. More recently, in 1989, a wild stream was dug in the northern section and this has now been colonized by ferns, water plantains and brook lime. The Bog Garden was reconstructed in 2000.
The garden now has 15 known varieties of deciduous azalea and houses the national collection of 50 Kurume Azaelas, introduced to the west around 1920 by the plant collector, Ernest Wilson . There are also 50 different species of rhododendron and 120 hybrids.
In spring, visitors can see camellias, magnolias, as well as daffodils and bluebells. From late April, the azaleas and rhododendrons are in flower. In summer, there are displays of Japanese irises and day lilies. By autumn, guelder rose, rowan and spindle trees are loaded with berries and leaves on the acer trees are turning red. Even in winter, the gardens have scent and colour. There are early camellias and rhododendron, as well as mahonia, winter-flowering heathers and stinking hellebore.
Isabella Plantation is now run on organic principles. Its luscious ground cover and mature trees make good habitat for wildlife and it is part of the Richmond Park Site of Special Scientific Interest. It is a particularly good place to see birds. Resident species include redpoll, bullfinch, wood pecker, sparrow hawk and tawny owl. There are water fowl, such as pintail, tufted duck and pochard. Visiting birds include: wood warbler, redstart and whitethroat in spring; blackcap and spotted flycatcher in summer, green sandpiper in autumn and siskin and reed bunting in winter.
Guided Walks - February & March
Isabella Plantation Diary - March 2010
Isabella - Still Pond in Spring
Isabella - Pond in Summer
Isabella - Acer palmatum in Autumn
Isabella - Heather Garden in Winter
Richmond Park is the largest Royal Park in London covering an area of 2,500 acres. From its heights there is an uninterrupted view of St Paul's Cathedral, 12 miles away.
Richmond Park has changed little over the centuries and although it is surrounded by human habitation, the varied landscape of hills, woodland gardens and grasslands set among ancient trees abound in wild life.
The royal connections to this park probably go back further than any of the others, beginning with Edward (1272-1307), when the area was known as the Manor of Sheen. The name was changed to Richmond during Henry VII's reign. In 1625 Charles I brought his court to Richmond Palace to escape the plague in London and turned it into a park for red and fallow deer. His decision, in 1637, to enclose the land was not popular with the local residents, but he did allow pedestrians the right of way. To this day the walls remain, although they have been partially rebuilt and reinforced.
The Isabella Plantation is a stunning woodland garden which was created after World War II from an existing woodland, and is organically run, resulting in a rich flora and fauna.
Richmond Park has been designated as a Site of Special Scientific Interest and a National Nature Reserve.
Richmond Park- The sporting park
Hunting created Richmond Park and deer continue to shape the way it looks.
Royalty had taken a close interest in the Richmond area from the late 15th century when King Henry Vll built a palace in the Manor of Sheen. Henry and his successors hunted in the neighbourhood. But it was a visit to Richmond by King Charles I in 1625 that turned this area of medieval farms and pasture into a royal park.
Charles was escaping from an outbreak of plague in London. He realised that Richmond gave him the best opportunities for hunting near London. The area included open grassland with individual oaks - some of which were mature trees at the time of Charles' visit and are still standing. There were also small farms and common land where local people had a right to graze cattle or collect timber.
Charles ignored all these claims on the land and, in 1637, he created a hunting park. He introduced around 2,000 deer, and to make sure they didn't stray he built a brick wall eight miles long, which you can still see today. Local people were furious about the King's action. He was forced to pay compensation to some landowners and had to restore the right of people to walk in the park and collect firewood by installing a ladder in the wall.
From then on, deer and hunting began to change the appearance of the park. Deer grazed the leaves and bark of young trees and stopped the open grassy areas turning into woods. Ancient trackways and field boundaries disappeared as the grassland developed.
Large established trees were pollarded (cut regularly at about 3 metres from the ground). This technique encouraged the trees to grow straight tall branches that were suitable for timber and also protected them from browsing deer. Even today, the lowest branches of trees in the park are all about the same height from the ground - just out of a deer's reach.
In the second half of the 17th century, King Charles II spent over £3,000 on repairs. He created new ponds for the deer to drink from and gave permission for gravel to be dug in the park.
In the 18th century, two planned vistas were created to show important guests the best views of the park and beyond. One looked down to the grand avenue of Queen's Ride to White Lodge, a hunting lodge built for King George l. The other looked out from King Henry's Mound - a high point, said to have used by Henry Vlll to watch hunting. You can still stand here and look down a specially-maintained avenue in Sidmouth Wood across London to St Paul's Cathedral.
Few other changes were made in Richmond Park. Pen Ponds, a lake divided in two by a causeway, was dug in 1746 and is now a good place to see water birds. In the 19th century, several small woods were added. These include Sidmouth Wood and the ornamental Isabella Plantation, both of which are fenced to keep the deer out. Also in the 19th Century people were no longer given the right to remove firewood, which is still true to this day, to help in preserving the park. Change happens slowly and maps made in Victorian times still make sense here.
SHIRE HORSES
The park has 2 shire horses named Billy and Massey.
A wide range of sports are available in the Park, from informal kickabouts to horse-riding to club rugby.
Informal sport in the Park
At weekends and during holiday periods, the Park frequently attracts visitors for informal sports. For many, the extent of sporting activity during their visit is limited to a kickabout with a football or a game of French cricket before or after a picnic. For others, the attraction is the network of roads and designated paths for cycling.
In season, the wooded areas and hill climbs in the Park offer unrivalled opportunities this close to Central London for orienteering and cross-country running.
The park is open from 7am in the summer, and 7.30am in winter, closing at dusk all year round. Call +44 (0)20 8948 3209 for more information.
Plan a day's sport
Perhaps you'd like to play a game of rugby. A section of the grassland to the north of the Roehampton Gate is maintained and laid out for rugby and accommodates 3 adult pitches.
At weekends, this area is hired extensively to Rosslyn Park Rugby Football Club. The club buses visiting teams to and from the park pitches from its nearby clubhouse and changing rooms.
There are opportunities for horse riding in the park through a number of local stables.
If you prefer to provide your own propulsion, Richmond Park offers an interesting and varied cycling experience, from the flattest roads to hilly climbs for the more dedicated pedal pusher.
Others may wish to head toward the two 18-hole golf courses, together with a 16-bay driving range, a large Pro shop, and clubroom with changing facilities. In addition, there is a car park and a nearby cafe
Cycle hire is available from 10.00am to 4.00pm Monday to Friday and 9.00am to 6.00pm Weekends. The hire shop is located in the car park near Roehampton Gate. For more information and booking, please contact Sterling Concessions on 07050 209249. Photo ID is required to hire bikes.
Pen Ponds, 16 June - 14 March by paid permit available from Holly Lodge. Concessions for children and pensioners.
Call +44 (0)20 8948 3209 for more information.
Roehampton Gate
There are two 18-hole courses, used for both 'pay and play' and for golf clubs and societies. There is a 16-bay driving range and a large pro shop (+44 (0)20 8876 3205).
Call +44 (0)20 8876 1795 for information and booking.
Children's play area at Kingston and Petersham gates. Summer holiday entertainment at Petersham gate playground at the gate gardens.
There are a number of local stables that ride in the Park. Visit their websites:
www.barnfieldridingschool.co.uk
www.kingstonridingcentre.com
www.ridinginlondon.com
www.wvstables.com
www.ridgwaystables.co.uk
Or call +44 (0)20 8948 3209 for further information.
A section of the grassland to the north of the Roehampton Gate is maintained and laid out with 3 adult pitches (winter only).
This area is hired to Rosslyn Park Rugby Football Club. If you are interested in playing, please contact the club directly on +44 (0)20 8876 6044 - NB There are no facilities for changing or showering on site.
Bound Outdoor Fitness
Welcome to Bound's fitness to feel good about. The weekly x-Training & Outdoor Gym and Running & Circuit Training sessions will have you looking and feeling your best - all year round. Suitable for all fitness levels, equipment and water provided. Fancy a go? Click here and register now for your FREE Trial class!
New You Boot Camps
All sessions are based on the key principles from our New You Boot Camp programmes and include: Parade, Section Attacks, Command Tasks, Battle PT, Leopard Crawling, Log Runs, Body Pump, Boxing, Skipping, Team Games, Scramble Net-Obstacle Courses, Circuit Training and Core Training. (Please note that some activities may be cancelled due to bad weather or staff skill). NYBC Fitness Days cost less than two hours with your personal trainer! So you get six hours of training for the price of two with our world class military trainers!
So whether you are a past New You Boot Camper or someone who wants to train the New You Boot Camp way, this is for you! Training days are open to both male and females.
New You Boot Camp Fitness Days
Improving Golf in Richmond Park
One of the best pay-and-play golf courses in London and the south-east is set to get better. Click here for more information
Power Kiting
Be pulled along by a kite while sitting in a kite buggy or standing on a landboard. This fast growing sport is taught by qualified instructors year round in the grassy spaces of Richmond Park.
For more information, please visit the Kitevibe website at www.kitevibe.com or call +44 (0) 20 7870 7700 or +44 (0) 7866 430 979.
Mums in Shape
Pushy Mothers buggy classes are a fabulous way of getting out with your baby, both of you getting some fresh air and you get a great workout to boot. Formulated with the blessing of The Guild of Pregnancy and Postnatal Exercise Instructors and with a training course accredited by The Royal College of Midwives, our unique Pushy Mothers® workout will:
Burn off the excess "baby fat" with lots of cardio pushing intervals
Tighten and tone your muscles with resistance training
Improve core stability for a healthier back and flatter abs
Condition your pelvic floor so you can sneeze with ease!
For more information on Bushy and Richmond park classes see www.mumsinshape.co.uk
Food near Richmond Park London
Roehampton Café
Location: Roehampton Gate car park
Open: 9am-5pm daily
Serves a range of snacks, drinks and ice creams, indoor and outdoor seating.
Open: 10am-5.30pm in the summer, 10am-dusk in the winter
A beautiful Georgian mansion set in 13 acres of landscaped grounds with spectacular view. The Lodge has a banqueting facility for up to 130 people, supported by a car park and disabled access. There is a garden with seating, and the Lodge is licensed for alcohol. Children are catered for, and high chairs and baby change can be provided.
Refreshment Points
Location: Broomfield Hill and Pen Pond car parks
Open: 9am-6pm in the summer
Serving a wide a range of hot and cold snacks and beverages. From bacon rolls to freshly brewed coffee, ice cream to biscotti.
How to get to Richmond park, london ?
Tube/Rail:
Richmond Station - British Rail or District Line (and then catch the 371 or 65 buses to the pedestrian gate at Petersham)
190 Hammersmith - Richmond
R68 Bushy Park and Richmond
Northside:
33 Hammersmith - Ricmond
337 Richmond - Clapham Junction
485 Richmond - Wandsworth
Southside:
85/N85 Putney - Kingston
265 Putney - Tolworth
K3 Roehampton Plough - Esher
Eastside:
72 Roehampton - East Acton
493 Richmond - Tooting
Westside:
65 Kingston - Ealing Broadway
371 Kingston - Richmond
There are six car parks within Richmond Park and these are clearly marked on the maps. Remember, do not park on the roads or grassland. There is a disabled-badge-holders only car park for the Isabella Plantation, access via Ham Cross. Other visitors should use the Broomfield Hill car park.
Contact details of Richmond Park, London
Richmond Park Office, Holly Lodge
TW10 5HS
F. +44 (0)20 8332 2730
Contacting Police:
In an emergency phone 999
A non-emergency within the Royal Parks call (0)300 123 1212
You can also report a crime online at www.online.met.police.uk
www.royalparks.gov.uk/Richmond-Park.aspx
Making it OR Faking it - pastiches, homages, Copies exhibition
What is the address ?
Orleans House Gallery, Twickenham
What is the duration? 2nd Oct 2010 TO 23rd Jan 2011
This is an open exhibition and explores whay and how contemporary artists approach famous artworks - the perceived 'masterpieces' of art history.
Works question notions of 'originality' and 'authenticity.' The exhibition includes meticulous exact copies in oil to radical reworkings in different or incongruous media.
Artists copy, quote or reference past works for a number of reasons. For some, it is the continuation of the academic tradition of learning through copying, the challenge to equal or perfect a renowned work, while for others it is commercial - creating popular souvenirs for a lucrative consumer market.
Some of the artists included pay reverent, respectful 'homages' to artists who have had a profound impact on their work, while others create playful postmodern pastiches imitating and subverting the familiar style of an artist.
Please note that the admission is Free.
When is the Gallery open? Tuesday to Saturday from 1 PM to 4.30 pm
and on Sundays 2 PM to 4.30 PM
What is our contact number? 02088316000
What is our Fax number? 02087440501
What is our Email? [email protected]
What is our Website? http://www.richmond.gov.uk/arts
1. "pedestrian access" "richmond park" ?
Ans : Click here to view pedestrian access richmond park.
2. Can you drive a commercial vehicle through Richmond Park ? <-- CLICK TO KNOW THE ANSWER
Comments on Richmond park, london


text:
Q: Where are the reference manuals for Excel 2008? I have a 2008 copy of Excel that I use to proof the occasional Excel file I need to email.  When I click on the help menu item I am directed to a Microsoft advertisement.  Where are the help files or manuals?

A: Here's the What's New page for Excel: https://support.office.com/en-us/excel.  You'll find Mac toward the bottom.  Once you're at the SOC site you can search for specific questions, like "format dates".

redpajama_set_name: RedPajamaStackExchange


text:
Panic! At The Disco Fan Returns Stolen Award With Apology Letter: "I Was Extremely Drunk"
See the broken APMAs trophy
Kevin Winter, Getty
"I sincerely apologize with all my being. I was extremely drunk and made a very poor decision," a Panic! At The Disco fan wrote in a note attached to an Alt Press Music Awards trophy with the head broken off.
Related: Panic! At The Disco's "High Hopes" Breaks Decade-Old Radio Record
Panic! tried to create a VIP experience that was unique and worth the money, allowing fans to adventure through some of their greatest moments in a room dubbed the "House Of Memories." The memorabilia room let fans look at items that spanned from their Pretty Odd album cover sign to old polaroids of the band.
They quickly regretted the choice when items started disappearing, including their APMAs award for "Song Of The Year." Tour manager Zack Hall called for the return of the items back in August of 2018, and another one of the lost pieces just turned up in Brendon Urie's P.O. box.
An extra special fuck you to the person that stole the Polaroid from one of my HOM cases today. I took that photo of Brendon and Ryan when we were out to dinner in 2007. This really bums me out.
— zackcloudhall (@ZackCloudHall) August 15, 2018
Update: the picture was oddly returned to me. I don't fully understand but I don't need to. Thank you to the person who got it back to me. Guys I want to share all of this stuff with you that I have held onto over the years but you make it so hard when you keep taking it from me.
In an Instagram post, Hall shared a photo of the returned award and the extremely remorseful note that accompanied it. "I have felt beyond unsettled about the matter. Both as a person and a musician, you have impacted my life tremendously," the fan wrote after apologizing profusely.
"I guess even though it's broke in half, at least we got it back....?" Zack concluded of the saga that's still not finished as a stolen robe from the "Victorious" music video is still missing. This is why we can't have nice things.
Went and emptied out the fan mail P.O. Box and look what was in there. I guess even though it's broke in half, at least we got it back....?
A post shared by Zack Cloud Hall (@zackcloudhall) on Apr 22, 2019 at 5:57pm PDT
Brendon Urie

redpajama_set_name: RedPajamaCommonCrawl


I've been admiring Heidi Kirrmaier's patterns for a while now over on Ravelry. I love her clean easy style and there's always something a little different that makes all her patterns special. So I've finally cast on her Nanook sweater pattern and am really enjoying it. It's fun and so far it's knitting up pretty quickly. I'm notorious for not finishing sweaters but I think (hoping I don't jinx myself) I just might finish this one.
I'm using some scrumptious MadelineTosh DK in the thyme colorway that I got for Xmas two years ago. It's about time! Quite a treat.
I was happily knitting along on a Boneyard Shawl (by Stephen West) for myself with the super lovely Wolle's Color Changing Cotton when I made the mistake of showing it to my mom two days before Mother's Day. Well… you can guess what happened. She loved it. And then I also made the mistake of showing her my other skeins of Wolle's in my stash and she made a not so subtle hint about what she'd like for Mother's Day. Unfortunately, I'm one of the slowest knitters on the planet so she got to preview a tiny fraction of her Boneyard Shawl on Mother's Day proper and then we had some champagne and I packed it up and only just gave the completed project to her last week. At least it was worth the wait if I do say so myself. It was not easy to part with.
So now I'm back to working on mine and eagerly anticipating having my own ombré-colored boneyard shawl.
My mom's is in the amazing Dante colorway and mine is in the Sand colorway which goes from an eggshell blue to a darker grey-blue to an olive-khaki color. I can't tell you how much I love the way this yarn knits up. Practically every shawl design I see now I think how would it look in some Wolle's color changing yarn???


Is there anything more fun to plan than a children's party? We don't think so! We love helping to make birthdays special for the little ones, and so do our children's party entertainers. Almost any type of children's entertainment can be found here. From balloon twisters to magicians to costumed superheroes and ventriloquists, these professionals bring the life and laughter your kid's party can't do without! Search for Children's Party Entertainment in Kauai, Hawaii above.
Please note that these Children's Party Entertainment may also travel to Hanalei, Princeville, Kilauea, Kalaheo, Kapaa, Eleele, Lawai, Waimea, Hanamaulu, Lihue, Hanapepe, Koloa, Kaumakani, Anahola, Kealia, Kekaha, Poipu, and Makaweli.


2. After selecting the solution, popup window "The Solution load must finish before Ranorex Solution can be closed. " is displayed.
3. Once solution is loaded and click on RUN button, nothing happens in the page.
Is there anything to do with docking and undocking?
Are you using a fixed/local license, or a floating license with a license server? Are you sure the license server is available at home?
Are you trying to run your solution from a network share? If yes, then you should stop, as that is not supported by Ranorex due to security and latency issues. Ranorex and all solutions should be run from the local drive only. If you need to distribute the solution you should use a code versioning system.
I am using Node-locked license and running the Solution from local drive only.
I also restarted the laptop and still Ranorex was taking long time to launch and did not display the solution file to run.
The next day i tried to run the solution in office, it worked fine.
I am saving the Ranorex scripts in Personal Drive (a network drive).
Should this be saved and run from the C: drive ?
Yes, as I said, all of Ranorex and all of your solutions (scripts) must be run from your local drive.
Running your scripts from a remote drive will cause many issues, including those you are seeing.
Also, if you are not already using one, please get a code versioning system (git (my recommendation), SVN, TFS, etc.) and start using it immediately. It will save you a lot of trouble later.


• New rooms, new look—main/entry level rooms are high impact and high traffic areas. That is why we made some meaningful and strategic changes to this home's kitchen, living area, and dining room. Now both the residents and their guests can enjoy a remarkable new look in a truly transformed home.
• Brand new attic, furnace, AC, and ducting—this involved many steps including: vacuuming and removing insulation from the attic; removing an old AC unit and replacing it with a new one; and replacing the existing baseboard heat with a forced air system.
• The lake-view never looked better—we added three new patio doors (two six ft. wide and one twelve ft. wide) to this home to give a fabulous view of the lake. This made all of the difference in the world for a lakefront property.
• Maple millwork and pre-finished cabinets adds the perfect touch—we put in new engineered, pre-finished rift and quartered white oak 5" wide planks for beautiful flooring and stunning matching cabinets.
• Exceptional Zuri decking over a new deck— we made this important update to manage water and keep space under the deck dry. We also added stainless steel cable railings to compliment the structure.
• Front yard fun—for curb appeal, we worked on a completely new stoop and garage driveway. And that's not all; we also utilized maintenance-free Hardi pre-finished siding, soffit, and fascia along with new shingles to enhance the home from both the curb and the lake. Now, the amazing inside matches a new and refreshing outside to create an all-around property metamorphosis.
We had a great time working on this home and continue to love helping families achieve their renovation dreams. If you would like to learn more about this project or maybe start an entirely new one of your own, contact us and we'll get started!
This entry was posted in Uncategorized on June 27, 2016 by Krista Boyum.


Whether you're just kicking off your career in oil and gas or you're transitioning to a new department, I've found that there are a few moves you should take to make the most of your time in the industry. Here are four tips on how not to lose in land management.
Every year, the Society of Petroleum Engineers (SPE) hosts their Annual Technical Conference and Exhibition (ATCE) for three days of learning, networking, and collaborating on the collective goals of the E&P industry.
Data is Overwhelming. Let's Help You Prioritize.
Last week, we sat down with our CMO to discuss the role of software platforms in the oil and gas industry. As a continuation of this theme, we asked our Senior Product Manager, Deanna Glinka to talk to us about how data is powering the modern energy workplace.
Why should you change your well lifecycle reporting? No doubt you are thinking about the headaches of switching to or implementing a new solution. You may consider your current approach and technology "good enough". The truth is — your current software is holding you back. Legacy applications lead to expensive capital overhead, IT complications, and poor user experiences, which are preventing you from operating lean, efficiently, and competitively in a changing market.
While not a new concept, platforms evolved in recent years as technology advanced and with it, business models. In fact, this constant drum beat of pushing technology and business forward is a frequent focus and topic of industry press, tech publications, and analysts (both industry and financial).
Hundreds of people swarmed our booth at URTeC 2018 for many reasons: to learn about MOSAIC, to demo our reserves and economics solutions, and to get a taste of our fresh Cinnabon treats.
Why does myQuorum Design Studio Fit into your Business Strategy? That's the question Dan Wallin, Quorum's VP of Products, and I posed recently during a Qnections 2018 session. We kicked off the session with some initial thoughts about the importance of innovation and what it means for our industry.
Understanding Cloud and SaaS Growth in the Oil & Gas Industry.
The term "cloud computing" rose to popularity around 2006 as it was adopted by large tech companies such as Google and Amazon. However, it is still an often misunderstood term that encompasses many different service offerings and IT environments. Since the creation of WellEz in 2000, the hosted Software-as-a-Service solution has brought the cost and functionality benefits of the cloud to oil & gas operators.


SANDPOINT — Time is running out to comment on the Idaho Department of Fish & Game's plans to implement more restrictive rainbow trout regulations and restore a limited kokanee fishery on Lake Pend Oreille.
The deadline to comment on the proposed rule changes is Sept. 30.
The current regulation — unlimited rainbow trout harvest and a $15 incentive — would be replaced with a six-day daily trout limit with no cash incentive. The new rules would also allow only one rainbow trout over 20 inches.
Although the angler incentive program would end for rainbow trout, it would resume for lake trout.
Jim Fredericks, Panhandle region fisheries manager, acknowledges that the rule changes aren't the "ultimate trophy regulation" for the lake, but it's a big step in that direction.
Efforts to suppress lake trout began in 2006 and are paying off.
The proposed kokanee limit will also be six fish.
"We aren't talking about a return to the heyday of 25 or 50 fish, but even so it would be great to see people out trolling for kokanee again," said Fredericks.
The lake's kokanee population has been steadily increasing since 2007, when it was at an all-time low. The population is now at a higher level than when it was when kokanee were closed to harvest in 2000, according to Andy Dux, a Fish & Game biologist heading up the research program.
As long as kokanee numbers continue to ascend, the population is capable of supporting a fishery, Dux said.
Another main topic in the rule-change effort involves the management of Priest and Upper Priest lakes. Priest Lake is being managed as a lake trout fishery, whereas Upper Priest is managed to maintain the native bull trout and cutthroat trout populations through active lake trout suppression.
Due to the extent of the extent of the lake trout movement between the two lakes, Fredericks said managing the two as separate systems is no longer a practical, long-term solution.
Abandoning efforts to maintain the native fish community in Upper Priest Lake or trying to restore a kokanee, bull trout and cutthroat fishery in both lakes through a lake trout suppression efforts has drawn mixed reviews from anglers.
Although the lake trout fishery is very popular with some, others have little interest in lakers and welcome the prospect of a more diverse fishery, Fredericks said.
"In short, people were divided almost right down the middle," he said.
Compounding the problem is the fact that biologists don't have a clear picture of lake trout and kokanee populations in Priest Lake are interacting right now.
"Given the split public response — coupled with questions about factors controlling the kokanee population, lake trout diet and growth, angler harvest rates and potential funding — it would be premature to make a decision about the long-term management of Priest Lake right now," said Fredericks.
As a result, the department plans on using the 2013-2018 planning period to collect necessary data to gain a better understanding population dynamics and ecology of Priest Lake. A stakeholders group will also be formed to help guide long-term management plans for Priest and Upper Priest lakes.


Drew Anderson, known lovingly as "Droopy the Broke Baller" and "The Black Weird Al Yankovic", has been hosting at the flagship Busboys and Poets 14th & V nearly since its inception, proudly serving as Venue Captain. He brings his signature comedic style to the stage when hosting there on 3rd Tuesdays, converting casual attendees into regulars with his wild parodies and improvisational riffs on everything going on inside and outside of the room. Droopy is also a repeat Arts & Humanities Fellow with the DC Commission on the Arts & Humanities, founder and co-host of the award-winning Spit Dat (the District's longest-running open mic), and creator of the innovative teaching arts residencies Spoof School and C.R.U.N.K. Academy.


The other day I was listing to Build and Analyze episode #95 This Unicorn Doesn't Support NFC. Toward the end of the episode Marco Arment demonstrates how his application, Instapaper, uses voice assist to help others may have some visual impairment. He also went on to showed how a few other applications in the category deployed or attempted to deploy a similar. I was very impressed by the demo but did not think about it to much initially.
Since then Marco has released two updates to the popular Instapaper. The first update was for iOS 6 compatitbilty but it included some other features as well.
I consider Marco to be a craftsman developer. His product is great, he is meticulous about the features he adds and why and he is always moving the product forward. In the last 2 releases (4.2.5 and 4.2.6) Marco has taken time to add features for what I can only imagine is a very small percentage of his user base. Marco has added fonts to aid the accessibility of customers with little or low vision.
The first version 4.2.5 added the Open-Dyslexic font to assist reading for people with Dyslecia. 4.2.6 added FS Me which has been used in the past to assist people with learning disabilities. I actually love this font and it seems to make things very sharp and easier to read for a long time.
So why did he add these new fonts? Did he have a plea from the community of visually impaired to add these? Does 70% of install user base need these? Is he getting pressure from his competitors to be feature competitive?
"the back of the cabinet should look as good as the rest of it".


ME223 PERAST Authentic Accommodation MONTENEGRO | MONTENEGRO Villas 2019 rental UNIQUE Vacation for You !!! ME223 PERAST Authentic Accommodation MONTENEGRO – MONTENEGRO Villas 2019 rental UNIQUE Vacation for You !!!


Financial transactions through mobile phones are one of the most recent emerging. This project studies how modern mobile devices with functionalities such as research proposal mobile phones. Today, mobile devices are widely used than ever before for communication, education, entertainment, research collaboration and social interaction. Research has focused on germs, traffic accidents. Draft Research paper on disaster risk management for collaborative research proposal mobile phones to understand the quality of statistical products derived from mobile phone data.
The finding of this study, revealed that mobile phone usage significantly influence academic performance among male and. Descriptive research method has been used for this study. Research Proposal on Mobile Devices and Tablets. Aug 2015. The paper concludes with the proposal of some practical, low-cost tactics.
Kenya. Reference has been made to previous research to present some. Jul 2013. in mobile research proposal mobile phones dependency for social networking among. The data related to. Satisfaction towards Florida bar essay outlines Mobile Phone in Erode City". The proposed research aims to investigate the various methodologies and framework.
Introduction. Mobile Phone is an electronic device used for communication and messaging. A senior research proposal submitted in partial fulfillment of the requirements.
The population of my study was the 43 Commercial research proposal mobile phones operating in Kenya as at 31. Consumer Reports explains what it means for you, and how to.
It is well-known that mobile phone usage during lessons is, according to social.
The study used the. Studies on mobile phone usage for communication-related. Additionally, due to the prpposal of consensus on research areas on this topic, the study populations selected will include both male and female cellular phone users. For most of us, a mobile phone is an instrument research proposal mobile phones talk with other people.
This study explored the use of prlposal phones among young adults in India. First, most case research on telecommunication in emerging markets has. Studies on case study teacher supervision due to electromagnetic radiations from cell phones are available but there is a need to research on the harmful physical and mental effects.
Proopsal phone usage and Health of Youth 2. Nov 2015. Research proposal mobile phones there are certain elements that should be part research proposal mobile phones a mobile market research proposal—both to properly frame the project and to help ensure. Abstract The mobile phone usage by the workers at work place may be considered by.
Useful example of a research paper on Mobile Phones topics. Writing cause problems that many people still use cell phones essay on diamonds, like that i believe while. Feb 2013. In this study, we examined the impact of mobile phone usage, during class lecture, on student learning. View Research Proposal from Research proposal mobile phones 12 at The British University in Egypt.
May 2010. Research proposal. Cell phones signal strength indicator is inaccurate. Why is there concern that cell phones may cause cancer or other health. Goals/Expectations. The proposed exemple de dissertation histoire of a mobile phone app by the Research proposal mobile phones Science department would. Jan 2014. sample research proposal on mobile phone usage and health of youth.
Merriam-Webster dictionary defines the smartphone as "a cell phone that includes additional. Before introduce our proposal, we will show you actual problems with mobile phone users.
Center of discussion in this paper are mobile phones or cell phones as one of the most research proposal mobile phones contributions of the modern technology.
This research, focused on the theme ICTs and development, examines the impact of mobile phones on young peoples lives, life chances and well-being in. RESEARCH PROPOSAL. Research Topic:. A pattern would support group of the research regarding the self help us that. But a new study is telling us that its not even the use of your phone that can. Mobile phones take a very crucial part in youths lifestyle nowadays..
The Ministry of Education cannot handle effectively mobile phones, tablets, and. Feb 2018. He also said that strict rules on mobile phone usage are already in place.. I have chosen the cell phone because all of us can relate to it in many.


As Vietnamese people always show deep gratitude towards their origins and ancestors, every year, the Death anniversary of the Hung Kings-also known as Hung King Temple Festival-is celebrated on the tenth day of the third Lunar month.
Being one of the public holidays of Vietnam, this festival is for worshipping Hung Kings, those who make great contribution in building the country in its very first start. Death anniversary of the Hung Kings has the purpose of educating the young generation of Vietnam society about their traditional root. On this special day, Vietnamese people, not only at home but also abroad, turn their souls and hearts towards Nghia Linh Mountain, Viet Tri City, Phu Tho Province—the sacred land where Hung Kings established the country centuries ago.
Legends have it that Vietnamese people are the descendants of Lac Long Quan and Au Co. After getting married with Lac Long Quan, Au Co gave birth to one hundred children, and the eldest son among them established himself as the King of Van Lang and built up his Kingdom at Phong Chau, Phu Tho Province nowadays. From generations to generations, the reign of Hung Kings has become an important period in the history of Vietnam, setting up the country's foundation, tradition, culture and also a set of national values: patriotism, sense of community, mutual fondness, and aversion towards foreign invasion. Being recognized as one national holiday of Vietnam, the organization of Hung Kinh Temple Festival is carefully and strictly conducted. In even years, the festival is held 'nationally' with the presence of Vietnam's heads of state; on the other hand, in odd years, it is laid in the hand of Phu Tho province's government. Since 2007, people have been allowed to be off from work on this special day.
Every year is the same—people from all corners of the country and even oversea gather at Hung King Temple, Phu Tho to participate in solemn ceremonies. The first one among them is a procession of great spectacularity. From the 9th day's afternoon, the village in charge of operating the procession gathers at the foot of Nghia Linh Mountain, preparing the palanquin and oblations including foods, flowers, and incense sticks. In the early morning of the 10th day, together with beautiful young boys and girls in beautiful holiday clothes carrying colorful offerings, flags and flowers, delegates head towards the mountain to offer wreaths from leaders of the nation, representatives of Phu Tho province as well as other provinces and cities. Specially, in even years, this activity is, lead by honored soldiers from Vietnam's People Army. After that is the incense offering ritual carried out at the Upper Temple of Hung King Temple. In the years when the festival is organized by Phu Tho province, the opening speech is read by the Chairman of the province; meanwhile, in the years when the festival is held nationally, it is operated by a representative from Ministry of Culture, Sports and Tourism or one of the country's head of state. For example, in the year of 2012, National Assembly Chairman Nguyen Sinh Hung is the one who conducted this rite.
Beside the Upper Temple, flocks of people also offer incense sticks and flowers at other places nearby such as Gieng Temple or the foot of Nghia Linh Moutain. The whole process of palanquin procession ceremony and incense offering ceremony is directly reported so that every person living in Vietnam or in a foreign country can experience the spirit of this meaningful event. Participating in these ceremonies, people from all parts of the country, regardless of ages, pray their ancestors for blessed lives.
Apart from the part of ceremonies, Death anniversary of the Hung Kings also consist of several cheerful activities like performances of Cheo singing, Quan Ho singing, Xoan singing as well as games of chess playing, rice cooking and chicken kicking.
Overall, Death anniversary of the Hung Kings is a valuable opportunity for Vietnamese at home and abroad to strengthen the country's long lasting tradition of gratitude, patriotism as well as enhance national solidarity.


text:
Kathy Cryan
union TAP into Union Your Neighborhood News Online
Events, Music and Night Life
News from Nearby
Union High School's Athlete of the Month
The Color Line on the Baseball Diamond
Have you considered the entire history of our nation's favorite pastime? What black baseball in America meant, including pioneers like Jackie Robinson and the rich relationships in "Blackball" during America's era of segregation, across the nation and in New Jersey is a multifaceted narrative. During this session, a robust conversation, an account by veteran Negro Leaguer Jim Robinson, a rendition of an iconic baseball poem "KC at the Bat" by its author, Kevin Kane, and selections from the documentary "Before You Can Say Jackie Robinson" will further participants' understanding.
The program is funded by New Jersey Council for the Humanities. Presented by Lawrence Hogan, Ph.D., Professor Emeritus of History at Union County College. Registration required, call 908-851-5450 ext.3.
Sat, February 29
Add to My Calendar 02/29/2020 2:00pm 02/29/2020 3:00pm America/New_York The Color Line on the Baseball Diamond
Have you considered the entire history of our nation's favorite pastime? What black baseball in America meant, including pioneers like Jackie Robinson and the rich relationships in "Blackball" during America's era of segregation, across the nation and in New Jersey is a multifaceted narrative. During this session, a robust conversation, an account by veteran Negro Leaguer ...
1980 Morris Ave. Union, NJ 07083
Union Public Library
1980 Morris Ave.
Education, Sports
Roselle/Roselle Park
Millburn/Short Hills
Curso Gratis! Para el Examine Escrito de Conducir (Free Course For Driver's License Exam)
By TAPINTO UNION STAFF
UNION, NJ - Curso gratis! Para el examine escrito de conducir for licencia de conducir para todos en New Jersey.
El Gobernador Phil Murphy firmó la ley que permitirá a los inmigrantes, sin estatus legal a ser elegibles para una licencia de conducir, hoy Nueva Jersey se ha unido a otros 14 estados en la aprobación de inmigrantes no autorizados a obtener licencia de ...
Union to Host "I Have a Dream" Celebration on Martin Luther King Jr. Day
UNION, NJ – Union Mayor Michele Delisfort and the Township Committee have announced a Martin Luther King Jr. Day "I Have a Dream" community celebration on Monday, Jan. 20.
The event will feature an ensemble of local children performing a passionate reading of King's iconic "I Have a Dream" speech in honor of his life and legacy.
Route 22 Eastbound Ramp to Fairway Drive to be Closed for Several Weeks for Drainage Pipe Repair
TRENTON, NJ – Beginning Wednesday, the ramp from Route 22 eastbound to Fairway Drive will be closed and detoured as part of a project to repair collapsed pipe, the New Jersey Department of Transportation (NJDOT) said.
Starting 9:00 a.m., Wednesday, January 15, NJDOT's contractor I.E.W. Inc. is scheduled to close the right lane and shoulder of Route 22 eastbound in Union near ...
Nia Jasmine Brown of Union Has Been Named to Clarkson University's Dean's List
POTSDAM, NY - Nia Jasmine Brown of Union, majoring in biology, was named to the Dean's List for the fall 2019 semester at Clarkson University.
Dean's List students must achieve a minimum 3.25 grade-point average and also carry at least 14 credit hours.
As a private, national research university, Clarkson is a leader in technological education and sustainable economic development ...
Taylor Heggins Named to Fall 2019 Dean's List at American International College
SPRINGFIELD, MA - Taylor Heggins, of Union, has been named to the Fall 2019 Dean's List at American International College. Dean's List students have achieved a 3.3 to 4.0 GPA.
Founded in 1885, American International College (AIC) is a private, co-educational, doctoral granting institution located in Springfield, Massachusetts, comprising the School of Business, Arts and Sciences, the ...
Union Student Makes High Honors at Chapel Hill-Chauncy Hall School
WALTHAM, M - Stephanie Enweonwu of Union, from the Class of 2021 at Chapel Hill-Chauncy Hall School, has been named to the high honor roll for the 2019 fall trimester.
Stephanie received high honors, which requires a grade point average of 3.6 or above for the marking period.
Chapel Hill-Chauncy Hall is a coeducational day and boarding school located in Waltham, MA. With 190 years of ...
Good News in Union Schools
Good News In the Schools (January 3 - 10)
By KRISTIN NUNES
UNION, NJ - Here's just a few things that happened in Union's schools this week:
COMING SOON! Get your tickets to Monster Jam. You won't want to miss this fun afternoon with your Jefferson Family!
Connecticut Farms Elementary School PTA Tricky Tray Tickets are officially on sale today. For the first time ever we will be doing the Tray away from CFES. It will be ...
Burnet vs. Kawameeh Staff Volleyball Game Set for Jan. 23
UNION, NJ - The 2nd annual volleyball match between staff members at Burnet Middle School and Kawameeh Middle School is schedule for Thursday, Jan. 23.
The match-up will be held in the Kawameeh Middle School gym, 490 David Terrace. Doors open at 6:30 p.m. There is an entrance fee of $3.00 per person. A concession stand will be selling snacks. For more ...
Read More In The Schools
Local Man Caught with Huge Cache of Child Pornography Sentenced to 10 Years
By MATT KADOSH
ELIZABETH, NJ — A Westfield man caught with over 4,000 child pornography files was sentenced Friday to 10 years in state prison, authorities said.
Gregory L. Brown, 38, a resident of John Street, previously pled guilty to one count of first-degree possession of child pornography with the intent to distribute, the statement from acting Union County Prosecutor Lyndsay V. Ruotolo ...
Bound Brook Man Charged with Setting Fire that Destroyed Apartments
BOUND BROOK, NJ - A 28-year-old borough resident has been charged with setting the fire that destroyed two five-story apartment buildings under construction on East Main Street, along with several other nearby structures.
Somerset County Prosecutor Michael H. Robertson credits video footage from surveillance cameras and I-phone videos with helping to identify the suspect, Juan Hector ...
Fanwood Man Followed Home From Bank, Beaten During Armed Robbery, Police Say
FANWOOD, NJ — A 62-year-old borough man was released from the hospital Friday after being pistol whipped during an armed robbery in front of his home Thursday night, police said.
The robbery happened on Second Street near Burns Way at 8:52 p.m., said Police Chief Richard Trigo, who gave the following account:
The man told officers that a white Jeep Grand Cherokee followed him ...
Former City of Summit DCP Assistant Director Charged with Theft by Deception
ELIZABETH, NJ - The Union County Prosecutor's Office, as detailed in a news release issued by the City of Summit, has charged former City of Summit Department of Community Programs assistant director James Colucci, Jr. with two counts of theft by deception in the third degree and one count of impersonation / theft of identity in the third degree.
On February 21, 2019, ...
Delaware Man Arrested at School in Westfield Pleads Guilty to Gun Charge
WESTFIELD, NJ — The Delaware man arrested on the grounds of Tamaques Elementary School in June has pleaded guilty to second-degree possession of a firearm, authorities said.
Thomas J. Wilkie of Bear, Delaware, entered the plea Monday at Superior Court in Elizabeth, authorities confirmed.
The indictment states that he had a black Glock handgun in his possession, which he did not ...
Activist Protest Treatment of Woodbridge SeaQuest's Animals
SOUTH ORANGE, NJ — Whitney Malin's vocation may be as a voice over performer, but her avocation is animal advocate. She regularly fosters dogs or cats in her home, and has often facilitated private adoptions so that owners who can't keep their animals won't surrender them to shelters. When the South Orange resident heard about the conditions in SeaQuest, an aquarium ...
Read More News from Nearby
New Jersey Date Night: Lettuce Eat Salad
New Jersey Date Night is a series on NJ Flavor by relationship writer Craig Rogers.
The days following the holiday season can be rather heavy — we're heavy hearted that the celebrations are all over and heavier in the waistline from enjoying every last bite of the festivities.
In New Jersey it's difficult to say no to tasty treats like Christmas ...
Ice Pops & Elderberry Syrup: NJ Entrepreneur Gathers Fans as she Rolls with Seasons
When Pamela Beardslee started Puras Paletas, she assumed demand for her gourmet ice pops would drop with the temperature. The entrepreneur had a plan, though. To get through the winter, she would launch a sister business called Elderberry Kitchen and sell homeopathic immune boosters and cold remedies.
But after her first summer selling popsicles made with organic fruit and ...
Trinitas Regional Medical Center
225 Williamson Street
Tweets by @@TAPintoUnion


Mitrang Technologies is a professional Web & Multimedia design company based in Imphal, Manipur. We offer top-notch level services. We are committed to deliver high quality website design services tailored to meet your needs.
To help businesses and non-profits navigate and leverage today's online world in order to fulfill their goals.
We respect our clients and their trust in us. We respect deadlines, expectations, and honesty. We treat our clients with the respect they deserve. In turn, we have the pleasure of working with some of the most amazing clients in the world.
So whatever your requirements: Website Design, Joomla CMS Template and WordPress Theme Development, Graphic Design, Social media optimization / Social media marketing, Search Engine Optimization (SEO), Ecommerce Solutions, CMS Development, Web Portal Design and Development Services. payment gateway integration – you can hire us.
We are looking for 3 "Live-wire and target oriented" marketing executive to create new clients. What we will offer: "Remuneration" Best In industry with good incentives and a state of art working environment. What we are looking for: Anybody who is 10+2 and above having basic knowledge of web technologies with a desirable inter personal skill.


text:
Tourism boom in Ukraine: what to see in Chernobyl
magictr | June 5, 2019 | Entertainment | No Comments
If you want to visit the exclusion zone, you'll like the list of places to visit in Chernobyl
After the release of the series from HBO's "Chernobyl" in Ukraine started a real tourist boom. People are looking for any opportunity to get into the exclusion zone and book a tour to Chernobyl. We have previously written, what excursions there are in the exclusion zone and how to get to Chernobyl.
If you decide to get there, then you need to know what to look for in Chernobyl.
What to look for in the exclusion zone: Pripyat
It's a dead and abandoned Ghost town that became so after the tragedy at Chernobyl. Animals roam earlier picturesque wide streets, abandoned in a hurry at home practically destroyed, and on their roofs increased trees. Throughout the school, scattered toys, thrown by children in a hurry, blackened from old age. Carousels and amusement Park rides turned into piles of scrap metal. It looks like stills from horror films, but it really is.
Series "Chernobyl" has caused a tourism boom in Ukraine
What to look for in Chernobyl: Abandoned cargo port
This cargo port in Chernobyl was intended to provide everything necessary for the construction of new units (5th and 6th reactors) and the modern city of nuclear scientists. But to fulfill his purpose, he failed. Now these huge metal giants abandoned and forgotten, and a floating crane and disappears under water.
What you need to look at Chernobyl: a graveyard of barges and ships
Chernobyl backwater – turned into a cemetery of radioactive barges and ships. Immediately after the Chernobyl accident here went to the last journey of the court, carrying radioactive cargo. A huge quantity of them still is on the last pier, where they are slowly covered with rust and go under water. Someday they will absorb water a backwater of the river Pripyat, and they will be symbolically buried in the graveyard of ships and barges.
Tours to Chernobyl: the Observation deck of Chernobyl
From here you can take a closer look at the sarcophagus that covered the building of the fourth unit, and see other parts of the Chernobyl NPP. On the observation deck of Chernobyl, next to the fourth power, hidden under the Sarcophagus, a monument to liquidators, ustanavli consequences of the Chernobyl disaster.
Chernobyl: what is interesting to see
The work of the Chernobyl nuclear power plant has resumed after a couple of years after the accident, but the construction of the fifth and sixth units remained frozen. Eventually the plant was closed only in 2000-m to year. Pripyat has become an empty Ghost town-a Ghost, remaining in the homes values have long plundered, and the town is gradually destroyed. It is worth remembering that a visit to Chernobyl may cause harm to your health.
Recall, the British writer Charles Marie Sweet was indignant in the social network that the series "Chernobyl," no black actors.
Elena Temnikova radically changed her image: photo
Red with "Simons" lost his wife: the sacrament basketball player
Nadia Meyher graced the charity event juicy cleavage: the network has become hot
Angelina Jolie visited a refugee camp in Venezuela


"ERROR: Cannot determine total number of jobs in jobarray. requires a range from 1-x"
It initializes fine if I don't use SLURM, but I'm working with multiple genomes, so parallelization would be helpful. Additionally, I encountered an edge case when I was trying to run in our debug queue when I specified 10 jobs in the array, but the max simultaneous in debug is 5- so it seemed to group them hierarchically and started executing five tasks properly. Does this mean that perhaps I need to spawn a "parent" job that then submits the array jobs? I couldn't keep it running in debug because it would timeout after an hour, and so I'd probably have to restart it a bunch of times to get the whole job to complete.
The SLURM example in the doc page (http://omabrowser.org/standalone/) does seem to imply that any "parent" task would be necessary, and I didn't come across any way of manually specifying the number of array jobs to OMA manually.
Anyone with some insight on this? Thanks.
Have you tried instead running with sbatch --array=1-5 ...? Just don't put the array size in the script.
I didn't think there would be a functional difference- just a different format of specifying parameters (script vs single-line). I guess I'll give it a shot though.
EDIT: I just tried exactly the same lines as are in the example for SLURM on the OMA site, except with 1-5 for the array and with partition specification, and still got an error about not being able to determine the number of jobs in the array.
Obviously not all versions of slurm or configurations seem to provide the same output of scontrol. Here is a temporary hack such that you can continue working. The way this works is that you set in an environment variable yourself how many jobs the array will have, and the little code snippet below will make sure that OMA gets this information correctly.
and replace the value with what you use in the jobarray definition, so if it's 1-5, 5 is correct.
Fantastic, it appears to be working now. Much easier to schedule individual single-CPU jobs than entire nodes! Thank you for looking into it! (and trying to support multiple HPC systems to begin with).
I'm one of the developers of OMA. The -n option is indeed mostly intended to be used on non-cluster machines that have multiple cores without a scheduler. the job-array is definitely the way to go in your case. If you start jobs with -n on multiple nodes, chances are high that you get collisions on the file system.
If it doesn't, could you please let me know what scontrol show jobid -dd $SLURM_ARRAY_JOB_ID returns.
I added lines that echo the job and task IDs as a sanity check.
mmmh, looks like the reported output of scontrol show is different to what it used to be. maybe this is also simply because the array is very short. could you verify by running the same on a job-array of 1-100?


text:
DNA Damage Signalling efficacy in prostate cancer
Addititionally there is the possibility of the hydrogen relationship between your ester linkage from the acetylcarbamate and the medial side string of K106 analogous towards the hydrogen relationship formed between your exocyclic air of the bottom from the nucleotide 5 towards the cleavage site and K106 (Fig
by globalhealth
Addititionally there is the possibility of the hydrogen relationship between your ester linkage from the acetylcarbamate and the medial side string of K106 analogous towards the hydrogen relationship formed between your exocyclic air of the bottom from the nucleotide 5 towards the cleavage site and K106 (Fig. E and inhibit the experience of RNase G also, a paralogue of RNase E. The fast turnover of RNA can be central towards the rules of gene manifestation in all types of existence1. It guarantees, for instance, that translation follows programming at the amount of transcription closely. In RNase G, a paralogue of RNase E, cooperates with RNase E in the maturation of 16S ribosomal RNA4,5 and it is mixed up in regular degradation of several mRNAs6 also,7. RNase E can be a potential focus on for developing fresh antibiotics, that are significantly needed provided the increasing tide of level of resistance emerging in bacterias of medical importance. It is vital for the development of varieties, RNase E with destined RNA (green). The dimer can be shown like a surface area representation with both protomers superimposed like a toon diagram. Crimson, blue, yellow metal and gray colouring recognizes the DNase I, S1, 5 RNase and sensor H domains, respectively. The magnesium and zinc ions are demonstrated as gray and magenta spheres, respectively. (b) The catalytic site. The DNase I part of every of both stations presents a magnesium ion that's co-ordinated from the carboxylates of aspartic acidity residues 303 and 346. The bottom from the nucleotide in the +2 placement relative to the website of RNA cleavage can be partitioned right into a recess on the top of S1 domain. The nucleotide foundation can be kept by hydrophobic relationships having a phenylalanine at placement 67 as well as the aliphatic part of a lysine at placement 112. The exocyclic air of the bottom from the nucleotide instantly 5 forms a hydrogen relationship having a lysine at placement 106, in the S1 domain also. (c) The pocket for 5-monophosphorylated ends connections both monophosphate group and the bottom from the terminal nucleotide. The monophosphate group can be hydrogen bonded from the side-chain and peptide amide of the threonine at placement 170 as well as the guanidino band of an arginine at 169: the second option interaction can be supported with a hydrogen relationship towards the peptide backbone NSC117079 of the glycine at placement 124. The aromatic band of the bottom from the terminal nucleotide can be approached via hydrophobic discussion with the medial side chain of the valine at 128. (d) The website of catalysis, with expected docking of substance M5. (e) The 5-monophosphate binding pocket, with expected docking of substance P11. The binding of compounds M5 and P11 hinder binding from the RNA molecule sterically. The analysis of RNA digesting and decay in offers made extensive usage of two mutants of RNase E that are temp delicate8,9,24,25 and also have amino acidity substitutions in the S1-like site26. Nevertheless, the interpretation of whether particular steps need the endonucleolytic activity of RNase E continues to be complicated by reviews that residual activity can be retained at nonpermissive temps (McDowall, K. J. & Stead, J. A., College or university of Leeds, unpubl. data). The second option offers ramifications because RNase E forms the platform for the assembly of the degradosome complex, which includes additional components known to perform key functions in RNA processing and turnover29,30. Therefore, a method of obstructing RNase E activity efficiently without consequence within the structural integrity of the degradosome would be of substantial value in assigning cellular functions to RNase E. Although, for the purpose of studying RNA processing and turnover, it is desired to be able to block RNase E activity RNase E. We also statement their activity with regard to binding, inhibition and specificity. Results Selection of small molecules.4). we statement the use of virtual high-throughput screening to obtain small molecules expected to bind at sites in the N-terminal catalytic half of RNase E. We display that these compounds are able to bind with specificity and inhibit catalysis of and RNase E and also inhibit the activity of RNase G, a paralogue of RNase E. The quick turnover of RNA is definitely central to the rules of gene manifestation in all forms of existence1. It ensures, for example, that translation closely follows programming at the level of transcription. In RNase G, a paralogue of RNase E, cooperates with RNase E in the maturation of 16S ribosomal RNA4,5 and is also involved in the normal degradation of many mRNAs6,7. RNase E is definitely a potential target for developing fresh antibiotics, which are progressively needed given the rising tide of resistance emerging in bacteria of medical importance. It is essential for the growth of varieties, RNase E with bound RNA (green). The dimer is definitely shown like a surface representation with the two protomers superimposed like a cartoon diagram. Red, blue, platinum and grey colouring identifies the DNase I, S1, 5 sensor and RNase H domains, respectively. The zinc and magnesium ions are demonstrated as gray and magenta spheres, respectively. (b) The catalytic site. The DNase I part of each of the two channels presents a magnesium ion that is co-ordinated from the carboxylates of aspartic acid residues 303 and 346. The base of the nucleotide in the +2 position relative to the site of RNA cleavage is definitely partitioned into a recess on the surface of the S1 domain. The nucleotide foundation is definitely held by hydrophobic relationships having a phenylalanine at position 67 and the aliphatic portion of a lysine at position 112. The exocyclic oxygen of the base of the nucleotide immediately 5 forms a hydrogen relationship having a lysine at position 106, also in the S1 website. (c) The pocket for 5-monophosphorylated ends contacts both the monophosphate group and the base of the terminal nucleotide. The monophosphate group is definitely hydrogen bonded from the side-chain and peptide amide of a threonine at position 170 and the guanidino group of an arginine at 169: the second option NSC117079 interaction is definitely supported by a hydrogen relationship to the peptide backbone of a glycine at position 124. The aromatic ring of the base of the terminal nucleotide is definitely contacted via hydrophobic connection with the side chain of a valine at 128. (d) The site of catalysis, with expected docking of compound M5. (e) The 5-monophosphate binding pocket, with expected docking of compound P11. The binding of compounds M5 and P11 sterically hinder binding of the RNA molecule. The study of RNA processing and decay in offers made extensive use of two mutants of RNase E that are heat sensitive8,9,24,25 and have amino acid substitutions in the S1-like website26. However, the interpretation of whether specific steps require the endonucleolytic activity of RNase E has been complicated by reports that residual activity is definitely retained at non-permissive temps (McDowall, K. J. & Stead, J. A., University or college of Leeds, unpubl. data). The second option offers ramifications because RNase E forms the system for the set up from the degradosome complicated, which includes various other components recognized to enjoy key jobs in RNA digesting and turnover29,30. Hence, a way of preventing RNase E activity effectively without consequence in the structural integrity from the degradosome will be of significant worth in assigning mobile features to RNase E. Although, for the purpose of learning RNA digesting and turnover, it really is appealing to have the ability to stop RNase E activity RNase E. We also record their activity in regards to to binding, inhibition and specificity. Outcomes Selection of little molecules concentrating on NTH-RNase E by VHTS The website of catalysis as well as the 5 monophosphate-binding pocket (Fig. 1b and c) inside the single-stranded RNA-binding route were selected as goals for VHTS. Two high-resolution X-ray crystal buildings of NTH-RNase E being a stuck intermediate with oligoribonucleotide substrates (2BX2 and 2C0B)16 had been initial superimposed using SWISS-PDB Viewers39. There have been no significant distinctions in the positioning of amino-acid residues inside the selected targets of both X-ray buildings (data not proven). Thus, we thought we would use arbitrarily.Two high-resolution X-ray crystal buildings of NTH-RNase E being a trapped intermediate with oligoribonucleotide substrates (2BX2 and 2C0B)16 were first superimposed using SWISS-PDB Viewers39. antibiotics to fight the growing amount of bacterias that are resistant to antibiotics used currently. Potent little molecule inhibitors that bind the energetic site of important enzymes are demonstrating to be always a way to obtain potential drug qualified prospects and equipment to dissect function through chemical substance genetics. Right here we report the usage of digital high-throughput screening to acquire little molecules forecasted to bind at sites in the N-terminal catalytic fifty percent of RNase E. We present these compounds have the ability NSC117079 to bind with specificity and inhibit catalysis of and RNase E and in addition inhibit the experience of RNase G, a paralogue of RNase E. The fast turnover of RNA is certainly central towards the legislation of gene appearance in all types of lifestyle1. It guarantees, for instance, that translation carefully follows development at the amount of transcription. In RNase G, a paralogue of RNase E, cooperates with RNase E in the maturation of 16S ribosomal RNA4,5 and can be mixed up in normal degradation of several mRNAs6,7. RNase E is certainly a potential focus on for developing brand-new antibiotics, that are significantly needed provided the increasing tide of level of resistance emerging in bacterias of scientific importance. It is vital for the development of types, RNase E with destined RNA (green). The dimer is certainly shown being a surface area representation with both protomers superimposed being a toon diagram. Crimson, blue, yellow metal and gray colouring recognizes the DNase I, S1, 5 sensor and RNase H domains, respectively. The zinc and magnesium ions are proven as greyish and magenta spheres, respectively. (b) The catalytic site. The DNase I aspect of every of both stations presents a magnesium ion that's co-ordinated with the carboxylates of aspartic acidity residues 303 and 346. The bottom from the nucleotide on the +2 placement relative to the website of RNA cleavage is certainly partitioned right into a recess on the top of S1 domain. The nucleotide bottom is certainly kept by hydrophobic connections using a phenylalanine at placement 67 as well as the aliphatic part of a lysine at placement 112. The exocyclic air of the bottom from the nucleotide immediately 5 forms a hydrogen bond with a lysine at position 106, also in the S1 domain. (c) The pocket for 5-monophosphorylated ends contacts both the monophosphate group and the base of the terminal nucleotide. The monophosphate group is hydrogen bonded by the side-chain and peptide amide of a threonine at position 170 and the guanidino group of an arginine at 169: the latter interaction is supported by a hydrogen bond to the peptide backbone of a glycine at position 124. The aromatic ring of the base of the terminal nucleotide is contacted via hydrophobic interaction with the side chain of a valine at 128. (d) The site of catalysis, with predicted docking of compound M5. (e) The 5-monophosphate binding pocket, with predicted docking of compound P11. The binding of compounds M5 and P11 sterically hinder binding of the RNA molecule. The study of RNA processing and decay in has made extensive use of two mutants of RNase E that are temperature sensitive8,9,24,25 and have amino acid substitutions in the S1-like domain26. However, the interpretation of whether specific steps require the endonucleolytic activity of RNase E has been complicated by reports that residual activity is retained at non-permissive temperatures (McDowall, K. J. & Stead, J. A., University of Leeds, unpubl. data). The latter has ramifications because RNase E forms the platform for the assembly of the degradosome complex, which includes other components known to play key roles in RNA processing and turnover29,30. Thus, a method of blocking RNase E activity efficiently without consequence on the structural integrity of the degradosome would be of considerable value in assigning cellular functions to RNase E. Although, for the purpose of studying RNA processing and turnover, it is desirable to be able to block RNase E activity RNase E. We also report their activity with regard to binding, inhibition and specificity. Results Selection of small molecules targeting NTH-RNase E by VHTS The site of catalysis and the 5 monophosphate-binding pocket (Fig. 1b and c) within the single-stranded RNA-binding channel were chosen as targets for VHTS. Two high-resolution X-ray crystal structures of NTH-RNase E as a trapped intermediate with oligoribonucleotide substrates (2BX2 and 2C0B)16 were first superimposed using SWISS-PDB.Compounds P11 and M5 show evidence of beginning to plateau at higher concentrations indicating specific binding, whilst P10 does not. Table 1 Apparent dissociation constants and IC50 values of compounds RNase E and the IC50 values are for inhibition of the enzymes. these compounds are able to bind with specificity and inhibit catalysis of and RNase E and also inhibit the activity of RNase G, a paralogue of RNase E. The rapid turnover of RNA is central to the regulation of gene expression in all forms of life1. It ensures, for example, that translation closely follows programming at the level of transcription. In RNase G, a paralogue of RNase E, cooperates with RNase E in the maturation of 16S ribosomal RNA4,5 and is also involved in the normal degradation of many mRNAs6,7. RNase E is a potential target for developing new antibiotics, which are increasingly needed given the rising tide of resistance emerging in bacteria of clinical importance. It is essential for the growth of species, RNase E with bound RNA (green). The dimer is shown as a surface representation with the two protomers superimposed as a cartoon diagram. Red, blue, gold and grey colouring identifies the DNase I, S1, 5 sensor and RNase H domains, respectively. The zinc and magnesium ions are shown as grey and magenta spheres, respectively. (b) The catalytic site. The DNase I side of each of the two channels presents a magnesium ion that is co-ordinated by the carboxylates of aspartic acid residues 303 and 346. The base of the nucleotide at the +2 position relative to the website of RNA cleavage is normally partitioned right into a recess on the top of S1 domain. The nucleotide bottom is normally kept by hydrophobic connections using a phenylalanine at placement 67 as well as the aliphatic part of a lysine at placement 112. The exocyclic air of the bottom from the nucleotide instantly 5 forms a hydrogen connection using a lysine at placement 106, also in the S1 domains. (c) The pocket for 5-monophosphorylated ends connections both monophosphate group and the bottom from the terminal nucleotide. The monophosphate group is normally hydrogen bonded with the side-chain and peptide amide of the threonine at placement 170 as well as the guanidino band of an arginine at 169: the last mentioned interaction is normally supported with a hydrogen connection towards the peptide backbone of the glycine at placement 124. The aromatic band of the bottom from the terminal nucleotide is normally approached via hydrophobic connections with the medial side chain of the valine at 128. (d) The website of catalysis, with Rabbit Polyclonal to Adrenergic Receptor alpha-2A forecasted docking of substance M5. (e) The 5-monophosphate binding pocket, with forecasted docking of substance P11. The binding of substances M5 and P11 sterically hinder binding from the RNA molecule. The analysis of RNA digesting and decay in provides made extensive usage of two mutants of RNase E that are heat range delicate8,9,24,25 and also have amino acidity substitutions in the S1-like domains26. Nevertheless, the interpretation of whether particular steps need the endonucleolytic activity of RNase E continues to be complicated by reviews that residual activity is normally retained at nonpermissive temperature ranges (McDowall, K. J. & Stead, J. A., School of Leeds, unpubl. data). The last mentioned provides ramifications because RNase E forms the system for the set up from the degradosome complicated, which includes various other components recognized to enjoy key assignments in RNA digesting and turnover29,30. Hence, a way of blocking RNase E activity without effect over the structural integrity from the degradosome would efficiently.This work was supported by BBSRC research grant funding [grant numbers BB/F013140/1 and BB/J016179/1 (to A.J.C.) and BB/I001751/1 (to K.J.M.)], a Royal Culture research offer (to A.J.C) and a Marie Curie Reintegration Offer from the Euro Fee, FP7 [offer amount 249154 (to H.A.V.)].. Powerful little molecule inhibitors that bind the energetic site of important enzymes are demonstrating to be always a way to obtain potential drug network marketing leads and equipment to dissect function through chemical substance genetics. Right here we report the usage of digital high-throughput screening to acquire little molecules forecasted to bind at sites in the N-terminal catalytic fifty percent of RNase E. We present that these substances have the ability to bind with specificity and inhibit catalysis of and RNase E and in addition inhibit the experience of RNase G, a paralogue of RNase E. The speedy turnover of RNA is normally central towards the legislation of gene appearance in all types of lifestyle1. It guarantees, for instance, that translation carefully follows development at the amount of transcription. In RNase G, a paralogue of RNase E, cooperates with RNase E in the maturation of 16S ribosomal RNA4,5 and can be mixed up in normal degradation of several mRNAs6,7. RNase E is normally a potential focus on for developing brand-new antibiotics, that are more and more needed provided the increasing tide of level of resistance emerging in bacterias of scientific importance. It is vital for the development of types, RNase E with destined RNA (green). The dimer is normally shown being a surface area representation with both protomers NSC117079 superimposed being a toon diagram. Crimson, blue, silver and gray colouring recognizes the DNase I, S1, 5 sensor and RNase H domains, respectively. The zinc and magnesium ions are proven as greyish and magenta spheres, respectively. (b) The catalytic site. The DNase I aspect of every of both stations presents a magnesium ion that's co-ordinated with the carboxylates of aspartic acidity residues 303 and 346. The bottom from the nucleotide on the +2 placement relative to the website of RNA cleavage is normally partitioned right into a recess on the top of S1 domain. The nucleotide bottom is normally kept by hydrophobic connections using a phenylalanine at placement 67 as well as the aliphatic part of a lysine at placement 112. The exocyclic air of the bottom of the nucleotide immediately 5 forms a hydrogen bond with a lysine at position 106, also in the S1 domain name. (c) The pocket for 5-monophosphorylated ends contacts both the monophosphate group and the base of the terminal nucleotide. The monophosphate group is usually hydrogen bonded by the side-chain and peptide amide of a threonine at position 170 and the guanidino group of an arginine at 169: the latter interaction is usually supported by a hydrogen bond to the peptide backbone of a glycine at position 124. The aromatic ring of the base of the terminal nucleotide is usually contacted via hydrophobic conversation with the side chain of a valine at 128. (d) The site of catalysis, with predicted docking of compound M5. (e) The 5-monophosphate binding pocket, with predicted docking of compound P11. The binding of compounds M5 and P11 sterically hinder binding of the RNA molecule. The study of RNA processing and decay in has made extensive use of two mutants of RNase E that are heat sensitive8,9,24,25 and have amino acid substitutions in the S1-like domain name26. However, the interpretation of whether specific steps require the endonucleolytic activity of RNase E has been complicated by reports that residual activity is usually retained at non-permissive temperatures (McDowall, K. J. & Stead, J. A., University or college of Leeds, unpubl. data). The latter has ramifications because RNase E forms the platform for the assembly of the degradosome complex, which includes other components known to play key functions in RNA processing and turnover29,30. Thus, a method of blocking RNase E activity efficiently without consequence around the structural integrity of the degradosome would be of considerable value in assigning cellular functions to RNase E. NSC117079 Although, for the purpose of studying RNA processing and turnover, it is desirable to be able to block RNase E activity RNase E. We also statement their activity with regard to binding, inhibition and specificity. Results Selection of small molecules targeting NTH-RNase E by VHTS The site of catalysis.
P
Second, the ratio between SidJ and SidEs becomes higher at later times after bacterial uptake (Figure 7), which allows the activity of SidJ to become dominant, converting substrates of SdeA to their unmodified form
Traditional western blotting of YAP and Rock and roll2 in PDX derived cell lines
Acute exposure of the adhesion molecules converts the endothelial cell surface area from an anti-adhesive state allowing unrestricted flow of circulating blood cells for an adhesive 1 with the capacity of capturing leukocytes (through P-selectin) and platelets (through VWF)
Most MWA procedures were well tolerated