text:
Artist Media
Hurt Performs "Shallow" in the Point Studio
By Point Webdude | May 27, 2014
Hurt joins Lux in the Point Studio before their acoustic show at Pop's on February 2nd, 2012. They play two acoustic songs in support of their upcoming album The Crux. See more at 1057thepoint.com/Lux
Shinedown – Sound of Madness(Acoustic)
Shinedown performs "Sound Of Madness" at an acoustic showcase for 105.7 The Point listeners in St. Louis, MO, on March 6th, 2012, in support of their new album Amaryllis available March 27th.
Shinedown – Simple Man(Acoustic)
Shinedown performs Simple Man in an acoustic showcase for 105.7 The Point listeners in St. Louis, MO, on March 6th, 2012, in support of their new album Amaryllis available March 27th.
Morning Parade Live in the Point Studio
Morning Parade stopped by the Point studio before their show at Pop's on Wednesday, September 26th for an interview with Donny Fandango and a live performance in the studio. Watch them perform a unique cover of Chuck Berry's "Back in the USA" as well as their single "Headlights".
Morning Parade Headlights Acoustic
Morning Parade stopped by the Point studio before their show at Pop's on Wednesday, September 26th for an interview with Donny Fandango and a live performance in the studio. Watch an awesome performance of their single "Headlights" recorded in the Point studio.
Morning Parade Covers Back in the USA
Morning Parade stopped by the Point studio before their show at Pop's on Wednesday, September 26th for an interview with Donny Fandango and a live performance in the studio. Watch them perform a unique cover of Chuck Berry's "Back in the USA"
Metric – Interview with Donny Fandango in the Point Studio
Metric stops by for an interview with Donny Fandango and performs "Breathing Underwater" acoustic LIVE in the Point studio before their show at the Pageant on October 2nd, 2012.
Metric – Breathing Underwater Acoustic Point Studio
Grouplove – Tongue Tied – Live Acoustic
Grouplove stops by the Point studio before their show at the Pageant on October 8th, 2012. They perform Tongue Tied, acoustic live on the air. Watch the performance. #Grouplove #TongueTied Lyrics: Take me to your best friend's house Roll around this roundabout Oh yeah Take me to your best friend's…
Grouplove – Colours – Live Acoustic
Grouplove stops by the Point studio before their show at the Pageant on October 8th, 2012. They perform Colours, acoustic live on the air. Watch the performance.


text:
46th President of the United States: 2021 ‐ present
FACT SHEET: Biden-Harris Administration Launches National Effort to Support Student Success
President Biden calls on schools to leverage American Rescue Plan funds to expand programming and services to help students make up for lost learning time and succeed
America's students are on average two to four months behind in reading and math because of the COVID-19 pandemic. President Biden understands the pain and loss our nation's students, families, and educators are experiencing, and is committed to supporting our nation's children. That's why President Biden's American Rescue Plan (ARP) provided an historic $122 billion in funding to help schools safely reopen and stay open, combat learning loss, and address student mental health and other needs.
Today, President Biden is calling on schools to use the $122 billion in ARP funds to provide high-quality tutoring, summer learning and enrichment, and afterschool programs that are proven pathways to helping students make up for lost learning time and succeed in school and in life, including by supporting their mental health. Building on President Biden's call to action in the State of the Union, the Biden-Harris Administration is also joining with leading organizations to launch the National Partnership for Student Success (NPSS) to provide students with an additional 250,000 tutors and mentors over the next three years.
We know what works: fully staffed schools, and personalized support for students through high-quality tutoring, summer learning and enrichment, and afterschool programs that help students not only make academic gains, but also stay connected to school and one another. The steps announced today will further help ensure America's children have what they need to thrive.
Use American Rescue Plan Funds to Provide Additional Instruction So Students Can Make Up for Learning Time Lost During the Pandemic
Thanks to the ARP, states and schools have the funds they need to help students recover from the pandemic. A majority of schools are already using these resources or have developed their plans to provide tutoring, mentoring, summer learning and afterschool programs, and to support staffing. Independent experts at Georgetown University have found school districts plan to spend over half of the $122 billion in ARP Elementary and Secondary School Emergency Relief funding for these purposes.
To ensure students are set up for success, the President is calling on states and school districts to continue using American Rescue Plan funds to fully staff schools and provide high-quality tutoring, summer learning and enrichment, and afterschool programs to support, on average, an additional four months of learning gains in reading and math. These programs are most successful when paired with initiatives that support student well-being and mental health, like arts and music, and the programs like those supported by the National Partnership for Student Success.
High-quality summer learning and enrichment: Multiple studies indicate that high-quality summer learning and enrichment programs lasting five weeks, with at least three hours of academic instruction per day, can help students gain roughly an additional two months of learning in math and one month in reading.
High-quality tutoring programs: Research has consistently shown that high-quality tutoring programs of a range of durations can produce about five months of additional learning. The best programs provide tutoring three times per week, for 30 minutes each day, and use teachers and well-trained volunteers.
High-quality afterschool programs: High-quality afterschool programs are associated with academic gains of roughly the equivalent of four months of learning, with positive impacts on attendance and student behavior as well. These high-quality programs include a concrete focus on skill development, including personal and social skills, and provide opportunities for students to practice new skills.
To help parents and schools ensure these critical supports are available in every district, the Administration is taking the following actions:
Tracking Progress in Providing Additional Learning Opportunities: The Institute for Education Sciences, the Department of Education's statistics, research and evaluation arm, will use monthly surveys to track schools' continued progress in providing summer learning and enrichment, tutoring, and afterschool supports.
Empowering Parents: Most decisions about how schools invest ARP funds are made at the local level and districts are required to engage families, educators and other stakeholders as they create their plans for using these historic funds. The Department of Education recently launched its National Parents and Families Engagement Council, and has created a new tool to help families and communities engage with district leaders around ensuring recovery funds are meeting students' needs. Using this interactive map, families and communities can review how their state and district plans to spend their ARP funds. Parents and families should engage their local leaders if plans do not adequately address the needs of their students.
Highlighting Schools Effectively Supporting Student Success: Today, the Department of Education is launching a campaign through the Best Practices Clearinghouse to highlight states and schools using ARP funds to support learning recovery and student mental health in evidence-based ways. The Department is calling on education leaders to nominate work for national recognition through the Clearinghouse.
Highlighting How States, Cities and Counties Can Help: Ensuring our students have the supports they need to succeed cannot fall on education leaders alone. States, cities and counties can use the American Rescue Plan's $350 billion in State and Local Fiscal Recovery Funds (SLFRF) to support student success. As outlined in a new White House toolkit, SLFRF can be used to hire and retain school-based staff; build the educator pipeline; and invest in other ways to support our students, including academic and mental health supports.
Recruit 250,000 New Tutors and Mentors to Help Students Succeed
Research shows that high quality tutors and mentors positively impact student achievement, well-being, and overall success. In fact, the CDC released analyses in March finding that students who are connected to adults and peers at school – the kinds of connections that tutoring and mentoring programs can foster -- reported better mental health outcomes than those without such connections. However, many schools need help recruiting and training the caring adults who are essential to implementing these high-quality, evidence-based programs.
Today, the Biden-Harris Administration, led by AmeriCorps and the Department of Education, is joining forces with leading national education, youth development, and service organizations and the Johns Hopkins Everyone Graduates Center to launch the National Partnership for Student Success (NPSS). NPSS will help expand high-impact tutoring, mentoring, and other evidence-based support programs that help students succeed. The NPSS will bring together school districts, non-profits and higher education institutions to recruit, train and place screened adults in high impact roles as tutors, mentors, student success coaches, integrated student supports coordinators, and post-secondary education transition coaches, with the goal of ensuring an additional 250,000 adults serve in these roles over the next three years. This will also help build the pipeline of educators. As more Americans gain experience working in our schools, more will seek out roles as teachers and student support professionals.
To support this effort, AmeriCorps will prioritize the American Rescue Plan's $20 million in Volunteer Generation Funds to assist non-profit organizations in recruiting and managing up to 200,000 additional volunteers in these critical positions in schools. The Department of Education has also made it clear that schools can use federal education funds as matching funds for AmeriCorps programs, making it easier for schools to partner with AmeriCorps grantees to support students.
President Biden is calling on Americans to come together to support our students in a number of different ways:
Individuals, from young adults to retirees, can learn more about supporting youth through a range of volunteer and national service opportunities, through AmeriCorps and the NPSS.
Community-based organizations and school districts can expand or improve tutoring, mentoring and other programs through the NPSS or through AmeriCorps
Employers across the country can pledge to support their employees in serving as volunteers, amplify these opportunities to serve, and get help in supporting these volunteer efforts.
Colleges and universities can learn more about and sign up to partner with K-12 schools and community-based organizations, providing their post-secondary students with meaningful opportunities to support K-12 students' success.
Organizations participating in NPSS include Accelerate, Afterschool Alliance, American Federation of Teachers, American School Counselor Association, Boys and Girls Clubs of America, Big Brothers Big Sisters of America, City Year, Communities in Schools, COVID Collaborative, MENTOR, National 4-H Council, National College Attainment Network, National Education Association, National Student Support Accelerator, National Summer Learning Association, AASA: the School Superintendents Association, and Voices for National Service. For a full list of participating organizations, visit https://www.partnershipstudentsuccess.org/.
Joseph R. Biden, FACT SHEET: Biden-Harris Administration Launches National Effort to Support Student Success Online by Gerhard Peters and John T. Woolley, The American Presidency Project https://www.presidency.ucsb.edu/node/356711

redpajama_set_name: RedPajamaCommonCrawl


text:
Lenovo Demon Slayer Chair
Lenovo Demon Slayer Chair. The post demon slayer & lenovo gaming chair collaboration features a katana holder appeared first on. The theme songs by lisa are pop hits.
Demon Slayer Katana Fake ANIME 4 2022 from anime407.rintisbisnis.com
Let's start with the basic stuff. In the meantime american fans can take solace in the fact that the demon slayer movie is soon coming stateside. A replica katana based on the one held by giyu tomioka, one of the major supporting characters.
Source: www.theverge.com
Lenovo 'demon slayer' gaming chair. The overall design is pretty typical from the bottom to the seat, which is where things start to get interesting.
Source: odkryj-moj-swiat.blogspot.com
The japanese animated series demon slayer (or kimetsu no yaiba in japanese) continues to spoil its fans with the good things. Stu levy, founder and chief executive of tokyopop, an american distributor and publisher of anime and manga, loves the way "demon slayer" brought together japanese folklore "with.
Source: 9to5game.com
Shadows die twice , ghostrunner , overwatch (if you're a genji main) or even cyberpunk 2077 , if you prefer swords to using guns. It is heavily based on one of the.
Source: www.thefpsreview.com
In the meantime american fans can take solace in the fact that the demon slayer movie is soon coming stateside. Shadows die twice , ghostrunner , overwatch (if you're a genji main) or even cyberpunk 2077 , if you prefer swords to using guns.
Source: hypebeast.com
Lenovo japan made a demon slayer gaming chair with a katana for those who don't follow manga, demon slayer: Stu levy, founder and chief executive of tokyopop, an american distributor and publisher of anime and manga, loves the way "demon slayer" brought together japanese folklore "with.
Source: www.techtimes.com
The gaming chair has been produced by lenovo in japan. Today it's become apparent that lenovo designed* a gaming chair in collaboration with the folks who make demon slayer / kimetsu no yaiba.
Source: www.asiaone.com
Yet the chair is designed to look something like giyu tomioka, a character in the anime demon slayer: A replica katana based on the one held by giyu tomioka, one of the major supporting characters.
Source: 9gag.com
Lenovo demon slayer gaming chair it seems like an ideal place to sit and play games like sekiro: Kimetsu no yaiba is basically a series that follows tanjiro kamado, a young boy who wants to become a demon slayer after his family is slaughtered and his younger sister nezuko is turned into a demon.
Source: au.finance.yahoo.com
Let's start with the basic stuff. In the meantime american fans can take solace in the fact that the demon slayer movie is soon coming stateside.
Source: www.slashgear.com
Lenovo's latest gaming chair is primarily aimed at anime fans. For those who don't follow manga, demon slayer:
Source: farmatux.com
It is heavily based on one of the. The overall design is pretty typical from the bottom to the seat, which is where things start to get interesting.
The company says it only made five of the unusual demon slayer: The theme songs by lisa are pop hits.
Source: fongma.blogspot.com
With our 12 year warranty and 30 day money back guarantee mavix is built to last. It is heavily based on one of the.
Source: raysofpeace.com
The gaming chair has been produced by lenovo in japan. For those who don't follow manga, demon slayer:
Source: windommedia.com
Let's start with the basic stuff. Today it's become apparent that lenovo designed* a gaming chair in collaboration with the folks who make demon slayer / kimetsu no yaiba.
Source: lafeeldesign.blogspot.com
Demon slayer series is available now on royale.sg at s$549. Lenovo's latest gaming chair is primarily aimed at anime fans.
Demon slayer series is available now on royale.sg at s$549. Lenovo demon slayer gaming chair it seems like an ideal place to sit and play games like sekiro:
Lenovo demon slayer gaming chair it seems like an ideal place to sit and play games like sekiro: Lenovo demon slayer gaming chair it seems like an ideal place to sit and play games like sekiro:
That's not what most people would notice first, however. Lenovo japan made a demon slayer gaming chair with a katana for those who don't follow manga, demon slayer:
Source: www.oneesports.gg
A replica katana based on the one held by giyu tomioka, one of the major supporting characters. The overall design is pretty typical from the bottom to the seat, which is where things start to get interesting.
Source: trendy-topics62.blogspot.com
Lenovo 'demon slayer' gaming chair. Yet the chair is designed to look something like giyu tomioka, a character in the anime demon slayer:
Source: anime408.rintisbisnis.com
Stu levy, founder and chief executive of tokyopop, an american distributor and publisher of anime and manga, loves the way "demon slayer" brought together japanese folklore "with. The gaming chair's design is designed after the popular japanese anime kimetsu no yaiba (demon slayer), particularly its mysterious character.
In the meantime american fans can take solace in the fact that the demon slayer movie is soon coming stateside. Today it's become apparent that lenovo designed* a gaming chair in collaboration with the folks who make demon slayer / kimetsu no yaiba.
For those who don't follow manga, demon slayer: A replica katana based on the one held by giyu tomioka, one of the major supporting characters.
This chair is decked out in a wine color, mostly on the seat. The chair's colors match the wardrobe of giyu tomioka of the demon slayer series.
In japan, "demon slayer" has spun off video games, toy figures, copycat products of the hero's earrings and happy meal stickers at mcdonald's. Shadows die twice , ghostrunner , overwatch (if you're a genji main) or even cyberpunk 2077 , if you prefer swords to using guns.
The chair's colors match the wardrobe of giyu tomioka of the demon slayer series. The overall design is pretty typical from the bottom to the seat, which is where things start to get interesting.
Shadows die twice , ghostrunner , overwatch (if you're a genji main) or even cyberpunk 2077 , if you prefer swords to using guns. In japan, "demon slayer" has spun off video games, toy figures, copycat products of the hero's earrings and happy meal stickers at mcdonald's.
Source: soranews24.com
Its color scheme mimics demon slayer character giyu tomioka's clothing. For those who don't follow manga, demon slayer:
Lenovo 'demon slayer' gaming chair. Its color scheme mimics demon slayer character giyu tomioka's clothing.
Source: latestlyhunt.com
Yet the chair is designed to look something like giyu tomioka, a character in the anime demon slayer: After announcing a fighting game last month, the franchise is now offering fans the chance to win an official demon slayer gaming chair.
For those who don't follow manga, demon slayer: Today it's become apparent that lenovo designed* a gaming chair in collaboration with the folks who make demon slayer / kimetsu no yaiba.
Source: geekculture.co
Lenovo demon slayer gaming chair it seems like an ideal place to sit and play games like sekiro: Shadows die twice , ghostrunner , overwatch (if you're a genji main) or even cyberpunk 2077 , if you prefer swords to using guns.
With our 12 year warranty and 30 day money back guarantee mavix is built to last. Today it's become apparent that lenovo designed* a gaming chair in collaboration with the folks who make demon slayer / kimetsu no yaiba.
Today it's become apparent that lenovo designed* a gaming chair in collaboration with the folks who make demon slayer / kimetsu no yaiba. The japanese animated series demon slayer (or kimetsu no yaiba in japanese) continues to spoil its fans with the good things.
This Chair Is Decked Out In A Wine Color, Mostly On The Seat.
In the meantime american fans can take solace in the fact that the demon slayer movie is soon coming stateside. Your eye will likely move immediately to. That's not what most people would notice first, however.
Lenovo Katana Gaming Chair From 'Demon Slayer'.
Per kotaku, the company has made a limited edition chair that has a holstered katana. Kimetsu no yaiba is basically a series that follows tanjiro kamado, a young boy who wants to become a demon slayer after his family is slaughtered and his younger sister nezuko is turned into a demon. It is heavily based on one of the.
The Chair's Colors Match The Wardrobe Of Giyu Tomioka Of The Demon Slayer Series.
The overall design is pretty typical from the bottom to the seat, which is where things start to get interesting. Lenovo's latest gaming chair is primarily aimed at anime fans. Today it's become apparent that lenovo designed* a gaming chair in collaboration with the folks who make demon slayer / kimetsu no yaiba.
Lenovo Demon Slayer Gaming Chair It Seems Like An Ideal Place To Sit And Play Games Like Sekiro:
For those who don't follow manga, demon slayer: The gaming chair has been produced by lenovo in japan. A replica katana based on the one held by giyu tomioka, one of the major supporting characters.
Today It's Become Apparent That Lenovo Designed* A Gaming Chair In Collaboration With The Folks Who Make Demon Slayer / Kimetsu No Yaiba.
The post demon slayer & lenovo gaming chair collaboration features a katana holder appeared first on. The theme songs by lisa are pop hits. Yet the chair is designed to look something like giyu tomioka, a character in the anime demon slayer:
Category: chair Tags: chair, demon, lenovo, slayer
← 2 Person Camping Chair Velvet Blue Chair →


The SKM AVX-835 is the handheld transmitter for the AVX digital wireless microphone system. The robust dynamic directional microphone reduces background noise in loud environments. It is the ideal choice for street interviews.
The SKM AVX-835 handheld transmitter for the AVX system and features self configuring digital transmission which eliminates time-consuming radio frequency setup. The AVX matches perfectly to your camera's input sensitivity without having to adjust the audio level on the microphone.
Q. What's so unique with AVX?
A. The ease of use of the system, you don't have to configure anything and you don't need to know about RF and audio engineering. The form factor of the receiver is unique and suits cameras. "Bodypack receivers are made for human bodies, not for camera bodies."
Q. What is special about the MMD 42-1 capsule?
A. An omni capsule (MMD 42-1) is a often used tool for interview situations. It helps capturing the sound well even when the microphone is not pointing directly to the person being interviewed.
A. Please refer to AVX accessory list.
Q. Is the output level adjustable?
Q. What's the audio quality and the latency?
A. AVX provides high-quality digital audio transmission with 24 bit/48 kHz sampling. The latency is 19 ms. Speaking in video terms, it's way less than one frame, thus audio and video are in sync.
Q. How can I charge the battery of AVX transmitter and receiver?
A. Charging is easy with the delivery included standard USB-charger or notebook or juice pack etc.
Q. What's the battery lifetime?
A. The transmitters last at least 10 hours, the receiver about 5 hours. BUT: AVX uses adaptive RF power switching. Additionally, it detects phantom power and switches off once the camera is switched off, that saves a lot of power and it will last for the full production day. We're using Lithium rechargeable batteries with Micro USB connectors. You also can use juice packs such as for your cell phone and charge the receiver during operation.
Q. Which RF band is used for AVX, do I need a license?
A. AVX uses the 1.9 GHz band which is license-free, protected, interference-free and future-proof. This band is less crowded than other digital bands and will also be available in the future.
Q. How many AVX devices can work in the same environment?
A. We suggest for the use in EU max 12 AVX channels, for the US 8 AVX channels. The only other system in that frequency range are cordless telephones.
Q. How does the transmitter know to switch the frequency?
A. The receiver measures the quality of transmission and initiates seamless switching to another channel for receiver and transmitter.
Q. Can I use multiple receivers with the same transmitter?
A. No, it's a point to point link only.
Q. Can I use multiple transmitters with one receiver?
Q. Can I use AVX all over the world?
A. AVX uses a global standard in 1.9 GHz. However, there are slightly different bands for different areas of the world. The U.S. version for example also can be used in Canada and most countries in Latin America. Please check with your dealer for specific information.
Q. How far is the reach of the AVX system?
A. In typical video application appr. 30 meters, but direct line of sight much more.
Q. What is the output power?
A. The AVX system is constantly checking the received signal strength of its paired device and adjusts the RF output power if needed to maximize the battery lifetime.
Q. Is the transimission encrypted?
A. Yes, AVX uses AES 256 bit encryption.
Q. What if I don't have an XLR input?
A. There is a XLR to mini jack adapter for the receiver included, as well as adaptors for camera shoe-mounting and a strap-clip.
Q. Does AVX replace Sennheiser's ew-G3?
A. No. AVX has a different target group compared to ewG3 –p. G3 offers more options and flexibility for the professional user with audio and RF background, AVX is for the self-contained videographer who needs to focus on capturing a story.
The S version also has a mute swtich.


Parents and caregivers are invited to have fun with their babies and toddlers in this five-week program. Play and bond with your child, meet other families, and speak one-on-one with experts in the fields of child development, speech and language, nutrition, and health.
For caregivers and their children ages 0 – 3.


Answer is c. Reference page 542 , Neville.
Q2)Nesbit PROSTHESIS IS USED IN?
Q7)Immunity present in a group of individuals in a community is called as..
Control city in this ?
Q14)microfilled composite size availbale is ????
Q15)Pan systolic murmur seen in all of the following except?
1)Which of the following is not the treatment for TMJ ankylosis?
Q25) Side effect Methaemaglobinemia is seen with which drug?
A) 42 weeks gestational age.
Q29) Q29)stillmann or bass tooth brushing technique utilizes which pattern of motion.?
Q38)Alterd cast technique in rpd?
40) widest palatal seal is achieved in ?
a).teeth with large pulp horns.
Q44)maxillary 3rd molar extraction positions which is wrong?
Q48)flouridated amalgam have or Fluoride concentration in amalgam?
Q50) initiation of hard tissue of max.lateral occur at?
Q51)most commonly used antibiotic for periodontal lesions?
Q52)Sutton disease is a feature of?
Q53)which is histological feature of brown tumour?
Q54)General lack of bone marrow activity is seen in which anemia?
Q55)Three canals and three roots seen in upper premolars are?
Q56)Which is not seen in cavernous sinus thrombosis?
Q57)which is best method to sterlize gutta percha?
Q58)Cavosurface margin for inlay is?
Q62)Which is not a part of epidemiology triad?
Q63)Patient suffering from prolonged decreased carbohydrate ingestion would lead to?
Q64) The centre of resistance to move maxillary anterior six tooth lie above?
81.4 degrees, with a standard deviation of 3.79.
plane angle and plus or minus the palatal plane angle.
against the molar displacement, with a correlation coefficient value of 0.643..
Q71)End stage organ involvement in hypertension depends upon?
Q73)if k ng vowels are used to judge?
80)Centre of resistance for bodily movement.
Q84)question was advantage of using niti endo instruments over stainless steel.
and is suffering frm 37°fever.he is suffering from?
Q87) )V is used to determine ?
Q88)which one resembles probability curve?
Q89)Addition of chromium in stainless steel does not cause?
90)Whole blood is stored at?
Q93)measure taken initially to prevent occurance of disease?
Q96)drug that hinders/delays orthodontic movement?
Q97) which of them is correct regardng tumor grading?
Q99)which of them is not done on day 1 of anug treatment?


text:
DNA-DNA-hybridisering refererar generellt till en molekylärbiologisk teknik som mäter graden av genetisk likhet mellan olika enkelsträngade DNA-sekvenser. Tekniken används oftast för att avgöra graden av genetisk distans mellan två taxa. När man undersöker den genetiska skillnaden mellan en mängd taxa, med hjälp av denna teknik, kan man med hjälp av värdena på den gentiska likheten konstruera ett fylogenetiskt träd; tekniken är därmed en metod för att skapa en molekylär taxonomi.

Charles Sibley och Jon Ahlquist var pionjärer inom tekniken och använde DNA-DNA-hybridisering för att undersöka de fylogenetiska släktskapen bland fåglar (Sibley-Ahlquists taxonomi) och primater. Kritiker menar att tekniken är missvisande när man använder den för att undersöka skillnader mellan nära besläktade arter, eftersom alla uppmätta skillnader mellan ortologa sekvenser mellan olika närbesläktade organismer överskuggas av hybridiseringen av paraloga sekvenser inom organismens genom. Idag används istället ofta DNA-sekvensering och sekvensjämförelser som metoder för att fastställa genetisk distans. DNA-DNA-hybridisering används dock fortfarande inom mikrobiologi för att identifiera bakterier.

Metodik
Metoden, framtagen av Sibley och Ahlquist, går ut på att jämföra smältpunkten för en enkelsträngad DNA-sekvens genom hybridisering sammanlänkad med en exakt likadan DNA-sekvens i jämförelse med samma DNA-sekvens sammanlänkad med en okänd DNA-sekvens från en annan organism. DNA från de två organismerna som ska jämföras extraheras, renas och delas upp i korta segment med cirka 600-800 baspar. Det enkelsträngade DNA-segmentet från den ena organismen märks med en radioaktiv isotop och blandas sedan med de omärkta DNA-segmenten för att låta dem länkas samman och skapa dubbelsträngat hybrid-DNA. De enkelsträngade DNA-sekvenser som har en hög grad av likhet kommer att binda hårdare till varandra och kräva en större mängd energi för att separeras. Med andra ord kommer de att separera vid en högre temperatur än de dubbelsträngade hybrid-DNA-sekvenser som har en lägre grad av genetisk likhet. Skillnaden mellan smältpunkten för de DNA-sekvenser som hybridiserat med sig själv och det DNA-sekvenser som hybridiserat med den andra organismens DNA-skevens avgör graden av genetisk distans och blir därmed ett mått på den genetiska likheten mellan de båda organismerna

Referenser

Noter

Källor
Texten är översatt från engelska wikipedias artikel DNA-DNA_hybridisation, läst 2007-05-29, där följande källa anges:
Graur, D. & Li, W-H. 1991 (2nd ed. 1999). Fundamentals of Molecular Evolution.

Molekylärbiologi

redpajama_set_name: RedPajamaWikipedia


text:
Extra Sci-Fi Reading & Media List
This list will be updated regularly with books and other works of science fiction media that we discuss on Extra Sci-Fi.
Some older books can be found online for free on Project Gutenberg, and many (if not all) of these books can be checked out for free at your local library or regional library system.
If you purchase a book through one of these specific Amazon links, we earn a (very) small percentage of the sale amount, which goes back into supporting the continued production of Extra Sci-Fi!
While Extra Sci-Fi strives to be a classroom-appropriate YouTube show, parents and educators who want to share these works with their students should review each work in advance to make sure it is a good match for the student's reading level and emotional maturity.
The History of Science Fiction (Season 1)
Frankenstein, by Mary Shelley (which draws heavily from the following works):
Paradise Lost, by John Milton
The Sorrows of Young Werther, by Johann Wolfgang von Goethe
Dante (most well-known for The Divine Comedy)
Plutarch's Lives
Short stories by William Gibson:
"The Gernsback Continuum"
"The Belonging Kind"
The Martian Chronicles, by Ray Bradbury
Works by Jules Verne:
20,000 Leagues Under the Sea
Paris in the 20th Century
Works by H.G. Wells:
The King in Yellow, by Robert Chambers
The Night Land, by William Hope Hodgson
House on the Borderland, by William Hope Hodgson
After London, by Richard Jeffries
A Voyage to Arcturus, by David Lindsay
Star Maker, by Olaf Stapledon
R.U.R. (Rossum's Universal Robots), by Karel Čapek
A Dreamer's Tales, by Lord Dunsany
Who Goes There? by John W. Campbell
The Golden Age of Science Fiction (Season 2)
I, Robot, by Isaac Asimov
Foundation & Empire, by Isaac Asimov
Starship Troopers, by Robert Heinlein
Stranger in a Strange Land, by Robert Heinlein
The Moon is a Harsh Mistress, by Robert Heinlein
The City and the Stars, by Arthur C. Clarke
Childhood's End, by Arthur C. Clarke
"Scanners Live in Vain," by Cordwainer Smith
The Demolished Man, by Alfred Bester
The Stars My Destination, by Alfred Bester
The World Builders (Season 3)
The Fellowship of the Ring, by J. R. R. Tolkien
The Two Towers, by J. R. R. Tolkien
The Return of the King, by J. R. R. Tolkien
Dune, by Frank Herbert
Dystopias and Apocalypses (Season 4)
Brave New World, by Aldous Huxley
1984, by George Orwell
Earth Abides, by George R. Stewart
Fahrenheit 451, by Ray Bradbury
Player Piano, by Kurt Vonnegut
A Canticle for Leibowitz, by Walter M. Miller Jr.
A Clockwork Orange, by Anthony Burgess
Stand on Zanzibar, by John Brunner
I Have No Mouth and I Must Scream, by Harlan Ellison
The New Wave (Season 5)
© 2017 - 2021 by Extra Credits, LLC. Extra Credits and Extra History are registered trademarks of Extra Credits, LLC in the USA and other countries.


A new tartan to mark Pope's visit to Scotland has been unveiled. This limited edition tartan was designed by Matthew Newsome and created in conjunction with two Scottish companies – Ingles Buchan of Glasgow and Clan Italia of Falkirk.
Cardinal O'Brien said: "It's a great honour to be able to hand over the first ever tartan created for a papal visit as a thank you to all the Holyrood parliamentarians who have been so overwhelmingly supportive of this visit, knowing it means so much to the Catholic community and many others in this country.
"I also intend to gift the tartan to the Holy Father only a week from today.
Is it possible for me to purchase a tie in the papal/St Ninian's tartan for my husband who is of Scottish ancestry and a life long catholic. I would like to buy one for him for a birthday/commeroration of the Holy fathert's visit.
Not just yet – Ingles Buchan are currently weaving a new batch of the papal/St Ninian's tartan. This will then be put on sale. The price will be slightly more than the other tartan scarfs as a donation is made to the church.


Getting yourself down to the gym can do SO much for your body, mind, and self-confidence. But some women avoid it (even if they know the facts).
Why have y ou been avoiding the gym? Is it fear of the unknown, or worrying that you'll look out of place?
Or perhaps you find gym training BO-RING!
There could be loads of reasons you find gym training dull. First up, find out why it's boring for YOU.
> Was there a time that you didn't find the gym boring?
> Is it just this gym you find uninspiring, or all gyms?
> Is it boring all the time, or just on certain days and times?
> Are you fed up with your workout, or with the gym itself?
Now you've got an idea of how your mind ticks. It's time to put some solutions in place, so you can enjoy the happy, healthy benefits of gym workouts.
Music makes training more fun – and can even make it feel easier. Science says so! (There are too many studies to mention, but if you're interested then just shout and I'll send your some to read over). Music can affect our heartrate, energy levels, and even rate of perceived exertion (RPE). Bottom line: if you're gym is playing great tunes (or you are listening to them on headphones), you are likely to enjoy your workout more.
Solution: Upload a great playlist to your MP3 player.
Solution: Ask a PT to help you create a new workout plan that will keep boredom away.
Solution: Be brave and sign up to something new. A great idea would be small group training > www.bjornfit.co.uk < – you'll get more personalised attention than in an exercise class, and you'll learn loads of new exercise ideas.
Why do you go to the gym? If the answer is "because I should…" then you won't stay motivated for long. You need a goal that means something to you. It doesn't have to be losing weight (in fact, I'd rather it wasn't – there's so much more to fitness than that!) Stuck for ideas? Talk to other women in the gym, private message me > m.me/bjornfit <, or ask a member of gym staff for some inspiration.
Solution: Set a goal that excites and motivates you!
Even the sportiest people get bored of training on their own. One of the best ways to keep motivated is to find a great training partner or train in a little group of likeminded people. Your sessions will be more fun, a bit social, and leave you feeling energised. And you'll be less likely to think "…not today" if someone's waiting for you!
Solution: Try local small group training > www.bjornfit.co.uk <.
Are you in the Maidstone area? This > www.bjornfit.co.uk < will definitely stop you from getting bored at the gym! Visit the website or send me a PM if you want to know more about it.


text:
Posted inNews, Portland, State
Honduran woman, daughter find safety in Maine while waiting for asylum
by Patty Wight, Maine Public June 24, 2018
Santa and her daughter, who are cautious about their identity. Credit: Patty Wight | Maine Public
A Honduran woman and her 10-year-old daughter who were detained at the border last month are now in Portland.
They are seeking asylum in the U.S., and as their case is being considered, they are staying with two young women who volunteered to help them.
It was the middle of the afternoon on Jan. 13 when Santa — she asked that her full name not be used — left Honduras. Through an interpreter, Santa said she left to escape violent threats.
"The gangs, they were threatening to kill us," Santa said. "They would send videos saying they would chop us up in pieces and kill us that way. Because they were mad because we voted for the president that they did not want to win."
Santa said she and her daughter boarded a bus and headed toward the U.S. They had no plan and few belongings, just a small bag with identification papers and extra clothes. They stopped at churches along the way for help, and waited in Mexico until the end of March to join a caravan of migrants.
"From there, from town to town, we would sleep in churches, or on sidewalks, or with people who wanted to support the migrants," Santa said.
They got rides when they could. Otherwise, they walked. It was an exhausting journey, and at times Santa said she feared for their safety. As they drew closer to the U.S. border, she worried that officials might take her daughter.
"We were scared because in the caravan, people were saying that they were going to take our children away from us," Santa said. "And they were saying that they could take our children and we would be deported back."
But despite this, Santa said they did not want to turn around.
"I said, 'I've sacrificed way too much, and I don't want to go back to my country,'" Santa said.
So they continued north. In early May, four months after leaving Honduras, they crossed the border in Tijuana. Santa and her daughter remained together, but she said she saw a woman who was separated from her children.
"One was two years old and the other was five years old. And she was crying. She said if I had known, I wouldn't have thrown myself into all of this. And we were there for about seven days," Santa said. "When we left, she was still there fighting her case. And she was crying. She just kept crying."
As she recounted her experience, Santa started to cry. After she was detained at the border, she and her daughter were flown to a detention center in Texas, where they waited for an interview about their asylum case.
"I was so scared they'd say my case was a negative case because so many other people that had happened to, and they were all crying," Santa said.
Santa wasn't the only one feeling anxious. Two young women in Portland were also awaiting word on her case.
"So, we found out that we would be hosting Santa and her daughter a week or so before they had crossed the border," said Meg, who also didn't want her full name used.
Meg and her roommate Anna connected with Santa through the national organization Showing Up For Racial Justice. They were looking for people willing to host migrants entering the U.S.
"So it was six weeks or maybe a month before they got here and it was just a weird waiting game," Meg said.
Meg and Anna, who are both 27, had been looking for ways to support migrants, and decided to open up their apartment as a place to stay.
"Just to be able to show that even if the U.S. government is sending out messages of hatred, that you can't stop the American people from being open-hearted and welcoming and taking people in," Meg said.
After Santa arrived at the detention center in Texas, she called Meg from time to time, seeking assistance to buy food and medicine for her daughter. Within a few weeks, Meg got a text from Immigration and Customs Enforcement that said Santa and her daughter were being released and needed transportation to Maine. Meg bought them plane tickets from money raised from friends and local churches. They arrived in late May.
"I just thought God has given them a lot of love in order for them to receive us," Santa said.
Santa and her daughter were found to have what's called "credible fear" about returning to Honduras. That means they can stay in the U.S. while they wait for their asylum case to be heard.
"This is the safest place that I could be," Santa said. "I don't feel threatened or scared. I can go out on the street and walk on the street. I'm not afraid somebody is going to come up and kill me with a knife. It's a very safe place to be."
Meg said she and Anna will host Santa and her daughter for as long as they need and are currently trying to find an attorney to take her asylum case. Though she faces an uncertain future, Santa recalled a dream her daughter had while at the detention center.
"She had dream that everything was going to be, turn out OK," Santa said. "And then when all of this came true, she was very happy because her dream came true."
This article appears through a media partnership with Maine Public.
Follow the Bangor Daily News on Facebook for the latest Maine news.
Tagged: Immigration
Previous Man charged with robbing Maine business at gunpoint
Next Clearing the clutter in our lives is one way we can find joy


text:
EBODAC
Communication strategy and tools for optimizing the impact of Ebola vaccination deployment
Ongoing | IMI2 |
Ebola and related diseases
Ebola+
Tools for predicting/monitoring efficacy
Grant agreement number
Type of Action:
RIA (Research and Innovation Action)
IMI Funding
EFPIA in kind
www.ebovac.org/ebodac
© 2017 EBODAC. All rights reserved. Licensed to the IMI2 JU under conditions.
Annik Willems
Janssen Pharmaceutica NV
The EBODAC project is developing a communication strategy and tools to promote the acceptance and uptake of new Ebola vaccines. One of the project's most important products will be a platform, based on mobile technology, dedicated to Ebola vaccines. As well as providing local communities with information on Ebola and vaccines, the platform will send reminders to people to get their second 'booster' dose and facilitate the tracking of vaccination coverage. EBODAC is also setting up local training programmes to make sure the communication strategy, and its tools, will be ready for deployment in the local setting.
Deployment of and compliance with vaccination regimens
For a vaccine to have a real impact on an outbreak, high levels of vaccination coverage are essential. In addition, for lasting protection, two doses of the vaccine may be needed. However, the stigma surrounding Ebola, coupled with a suspicion of vaccines in general, could deter many people from getting vaccinated. Strong communication campaigns are therefore needed to address these challenges.
The EBODAC project is developing a communication strategy and tools to promote the acceptance and uptake of new Ebola vaccines. One of the project's most important products will be a platform, based on mobile technology, dedicated to Ebola vaccines. As well as providing local communities with information on Ebola and vaccines, the platform will send reminders to people receiving the 'prime boost' vaccine to return to get their second 'booster' dose and facilitate the tracking of vaccination coverage. EBODAC is also setting up local training programmes to make sure the communication strategy, and its tools, will be ready for deployment in the local setting.
A part of the Ebola+ Programme
The IMI Ebola+ programme was launched in response to the Ebola virus disease (EVD) outbreak that started in western Africa in 2014. The comprehensive programme contributes to efforts to tackle a wide range of challenges in Ebola research, including vaccines development, clinical trials, and transport, as well as diagnostics. The programme complements work being carried out with the support of other funding bodies. In addition to Ebola, the programme will also address related diseases, such as Marburg.
About Ebola and related diseases
Ebola virus disease (EVD), previously known as Ebola haemorrhagic fever, is a rare and deadly disease caused by infection with one of the Ebola virus strains. The virus spreads in the human population through direct human-to-human contact with the bodily fluids of infected patients who are showing symptoms. It has an incubation period of 2-21 days, and it usually begins with flu-like symptoms, but rapidly progresses to multiple organ failure and blood-clotting abnormalities which manifest as internal and external haemorrhages (bleeding). It is fatal in between 25% and 90% of cases. There is currently no licensed treatment against EVD, and the development of treatments and preventive measures such as vaccines is hampered by challenges including manufacturing-related hurdles, the stability of vaccines during transport and storage, vaccine deployment, and the time taken to diagnose cases of EVD.
Ebola is a member of the filovirus family of viruses, which also includes Marburg virus. Like Ebola, Marburg causes cause severe, often fatal haemorrhagic fever in humans and other primates (monkeys, gorillas and chimpanzees), and like Ebola, it is transmitted directly from one person to another. (In contrast, other viruses that cause haemorrhagic fevers are spread via intermediate hosts - for example, dengue fever is transmitted by mosquitoes.) There is no specific treatment or vaccine against Marburg haemorrhagic fever.
The 2014-15 Ebola epidemic was unprecedented in its scale and geographical distribution. By the middle of 2015, World Health Organization (WHO) statistics recorded over 27 000 cases and 11 000 deaths from the disease, most of them in Guinea, Liberia, and Sierra Leone. The epidemic highlighted the need for research into better vaccines, diagnostics and treatments to stop future epidemics in their tracks.
New brochure: IMI – radical collaboration in action
A new brochure showcases success stories from IMI projects in infectious diseases, brain disorders, diabetes, cancer, and other areas.
Of vaccines, rumours and the success of IMI's EBODAC project
When IMI's EBODAC project started in late 2014, Ebola had already killed over 8 000 people in just a few short months, most of them in the western African nations of Liberia, Guinea and Sierra Leone. With the outbreak continuing to devastate lives across the region, fear and anxiety were rife, and rumours spread rapidly through local communities.### It was against this backdrop that IMI's EBODAC project set out to develop a community engagement strategy to enable a clinical trial of a promising new Ebola vaccine candidate. Thanks to the many innovative methods employed, including radio and drama shows, the project is now celebrating its first big success: all of the adults in the trial have been successfully vaccinated. 'The success of the project wouldn't have been possible without the public-private partnership nature and the support of IMI,' said Heidi Larson of the London School of Hygiene & Tropical Medicine, the EBODAC project coordinator. 'Given the sensitive nature of our trust-building, community engagement, communication and rumour management, it was particularly important that the funding for that dimension of the trial was coming from the public sector rather than the industry. At the same time, the private sector partnership was crucial to the collaboration and the success.'
Read the full success story
EBODAC project organises symposium in Senegal
IMI's EBODAC project is developing strategies and tools to promote the acceptance and uptake of new Ebola vaccines in local communities in Africa. In this context, the EBODAC consortium is organizing a symposium entitled 'Community engagement, communications and enabling technology in Ebola clinical trials'. ###The symposium will take place on 20-21 February in Dakar, Senegal. It will gather experts from around the world to discuss communications, community engagement strategies, and technologies used in clinical trials during the Ebola outbreak. Moreover, the event will offer an opportunity to exchange lessons learned, develop recommendations for future trials occurring in outbreak settings and gather insights to develop an open source online training tool focusing on community engagement. Prominent speakers will include Professor Peter Piot, Director of the London School of Hygiene & Tropical Medicine and co-discoverer of the Ebola virus, and Dr Awa Marie Coll-Seck, Senegal's Minister of Health. The event is by invitation only. If you are interested in attending please contact Valérie Heywood: valerie.heywood@lshtm.ac.uk.
EBOVAC trial in Sierra Leone starts; boosts local health infrastructure
A clinical trial of an investigational Ebola vaccine regimen is now underway in Kambia, Sierra Leone thanks to the IMI projects EBOVAC1, EBODAC and EBOMAN. ###
Even in the short term, the benefits to the local community of the 'EBOVAC-Salone' trial are immense; new facilities had to be built to run the study, including the first emergency room at the local district hospital, and a vaccine storage facility. In addition, the project provides both jobs and training for local healthcare workers, who will also gain valuable experience by working on the trial. In the longer term, the community may also benefit if the vaccine regimen is approved.
Sierra Leone was at the epicentre of the Ebola outbreak, with 14 000 cases and 4 000 deaths, including many healthcare workers. The vaccine regimen under investigation is a 'prime-boost' regimen, in which two doses are given several weeks apart. The first dose 'primes' the immune system, while the second 'boost' reinforces its effects with the goal of potentially strengthening and optimising the duration of the immunity. The study is notable in that it will evaluate the vaccine regimen's safety and immune response within the general population of Sierra Leone, including vulnerable groups such as adolescents and children. The vaccine regimen is also in trials in other parts of Africa, Europe and the US.
The EBOVAC-Salone trial is working closely with the IMI project EBODAC, which aims to ensure the prime-boost vaccine regimen is well accepted and successfully deployed. It is doing this by informing local engagement strategies, designing graphical communication aids, deploying technological solutions to increase compliance and uniquely identifying trial participants.
Participants Show participants on map
EFPIA companies
Janssen Pharmaceutica Nv, Beerse, Belgium
Universities, research organisations, public bodies, non-profit groups
Grameen Foundation Usa, Washington, District of Columbia, United States
London School Of Hygiene And Tropical Medicine Royal Charter, London, United Kingdom
Small and medium-sized enterprises (SMEs) and mid-sized companies (<€500 m turnover)
World Vision Of Ireland Lbg, Rathmines Park, Ireland
World Vision International, Monrovia Ca, United States
World Vision Sierra Leone, Freetown, Sierra Leone
IMI funding per project participant
IMI funding in €
Grameen Foundation Usa 3 454 516
London School Of Hygiene And Tropical Medicine Royal Charter 3 380 903
World Vision Of Ireland Lbg 5 318 468
World Vision International 2 000 000
World Vision Sierra Leone 6 174 970
Total Cost 20 328 857
This project is funded by the Innovative Medicines Initiative, a public-private partnership between the European Union and the European Federation of Pharmaceutical Industries and Associations (EFPIA)
www.imi.europa.eu


In 2012 Lester Grinspoon received the Cannabis Culture Award.
Lester Grinspoon is Professor Emeritus of Psychiatry at Harvard Medical School. He founded the Annual Review of Psychiatry and the Harvard Mental Health Letter, of which he was editor in chief for 15 years. His interest in cannabis dates back to the 1960s, when recreational use of the plant was on the rise. Grinspoon's research began in 1967 under the assumption that cannabis was a very dangerous drug. He reached the conclusion he and the general public had been misinformed and misled and he was convinced cannabis was much less harmful than he had believed.
Since 1967, Grinspoon has grown to become one of the world's most authoritative experts on cannabis, he meant a lot to the rediscovery of cannabis as a medicine. Since the publication of his by now classic book 'Marihuana reconsidered' in 1971 he has lobbied tirelessly for rehabilitation and against criminalization of the plant.
Ed Rosenthal (born Bronx, New York, 1944) is a California horticulturist, author, publisher, and Cannabis grower known for his advocacy for the legalization of marijuana (cannabis as a drug) use. In 2005 he received the Cannabis Culture Award in recognition of his achievements in the field of medicinal marijuana. He developed and promoted civil regulation policies for medicinal cannabis in California and his personal struggles with the American justice system have drawn attention to the irrationality of U.S. federal drug laws, and the harm and suffering those laws inflict on sick people. He is also the author of many popular informative books on growing and using cannabis. The official presentation of his award was held in Amsterdam's Cannabis College, which has long been a cornucopia of information on all applications of cannabis and hemp.


The 2014 Tour of California startlist is heavy on sprinters, and they'll get their first chance at glory with this 193-kilometer loop out and back from Sacramento. After the start in downtown, the race follows a leisurely northeast route to the foothills of the Sierra Nevada.
The climbs aren't tremendously difficult, but we will see our first KoM jersey awarded, likely to a member of the inevitable early breakaway. With a long, slightly downhill run back to Sacramento, the group will come back together for the finish. The pack will be watchful for crosswinds on the last 30 or so miles, but unless it breaks into echelons, we'll see a bunch sprint after three laps around Capitol Park.
The time trial comes early this year, and this stage will help set the early overall standings. But this TT is relatively short and has no significant difficulties in terms of terrain or tricky turns; it's a pure power course. Given that the race has two mountaintop finishes, it's unlikely the winner of this stage will emerge victorious overall, but keep an eye on relative time gaps between the GC contenders, as finishes here will be an indicator of form.
With a finish identical to the 2013 editions's queen stage, this summit finish will immediately reveal the challengers for the overall title. The climbing starts early, with a 4,000-foot ascent up Mount Hamilton right out of the start in San Jose. That will set the early break and make for a long day for dropped riders.
The peloton will probably regroup by Livermore (site of last year's start of this stage) but crosswinds and the likely May heat of the Central Valley could make for hard conditions. The finish climb up Mount Diablo isn't as long as Hamilton, but it's steeper and fairly consistent. Last year, Tejay van Garderen sewed up the overall here, but coming so early in the race in 2014, it may not be as decisive.
This is a classic Tour of California stage, down the Central Coast almost entirely on the Pacific Coast Highway. There are several climbs but nothing of note. Crosswinds off the ocean will be the central difficulty of the day.
Look for an early breakaway to get clear. If winds are favorable (cross-tailwind), it could survive all the way to the finish, but several powerful teams, like Cannondale and Omega Pharma–Quick-Step, are focused on sprinters. They will try to bring things back together for a bunch gallop.
Another likely sprint stage, this one heads inland for a course along the east side of the California Coast range. It'll likely be hot and possibly windy. There's a significant climb, up San Marcos Pass, with the summit just 28km from the finish line.
The dynamic will be the tug-of-war between the early break, any late-escaping stage hunters who break clear on San Marcos, and the sprinters' teams. The San Marcos climb isn't terribly steep, but a fast pace could burn off sprinters who aren't climbing well. While there are usually a few die-hard breakaway optimists, our bet is that this one ends in a bunch sprint.
A brand-new finish climb, Mountain High is a ski area tucked onto the backside of the San Gabriel Mountains above Los Angeles. This is no faux mountaintop finish like Big Bear from the 2010 and 2012 courses. The Mountain High summit is a roughly 23km-long climb with more than 3,500 feet of elevation gain, topping out over 7,000 feet high.
It's not the longest stage, but it is up and down all day, and riders will feel as if they're riding inside a hair dryer as they pass through the Palmdale area. The final climb is where it will all fall apart; it gets steeper at the top, so the summit is perfect for a pure climber to win the stage, and perhaps the overall.
Riders will experience a bit of déjà vu as they head back to Santa Clarita for the start of Stage 7. But instead of heading to Palmdale as on Stage 6, they'll turn into the San Gabriels at Acton and do the upper Big Tujunga Canyon climb to the Angeles crest.
There's more than 7,500 feet of climbing on the stage, but there's also a long, fast descent to Pasadena and three finishing circuits. One or two of the sprinters may be dropped, but it's still likely to be a big bunch finish.
This is the same course used in 2010, with four laps of a 32km circuit that includes LA's famous local proving ground, the Rock Store climb. It's just 4.2km long, but with four ascents, this stage adds up to more than 8,000 feet of climbing. Plus, it's a technical descent back to the finish in Westlake Village.
Unless the overall classification is extremely tight, look for the familiar tussle between the break and the sprinters' teams. The climb will probably keep a few fast men out of contention, and in 2010 Ryder Hesjedal won out of a select group with a late attack.


From the patent-pending Crossflame(tm) burner technology packed with 30,000 BTUs, which yields an even-flow of heat down to the furthest corner of the grill, to the Power Pro(tm) Top Burner and CR6(tm) indoor burner, a 23,000 BTU patent-pending powerhouse, giving you the power to sear, sauté, boil or melt whatever you need while preparing your culinary feast. Caliber has meticulously designed their products not just for restaurant-grade power and efficiency, but for flexibility and versatility-bringing to life your fantasy kitchen.
The indoor estate-scaled line of 36" and 48" all-gas ranges and cooktops were designed in collaboration with the country's top architects and designers. The Caliber Indoor Professional Range and Rangetop series is completely customizable in color and trim finishes, making Caliber the first American manufacturer capable of producing entire custom cooking suites for home culinary enthusiasts.
Caliber Appliances builds their award winning outdoor products with passion for culinary design and innovative engineering. Every line, every feature, every detail down to the tooling on the burners is crafted with an intense devotion to providing the customer amazing results - hands-down, you can Expect Great Heat from Caliber products.


Let us choose toys for you!
Don't know what you want? Your birds indifferent? In a rush but need some new toys?
Let me shop for you! Pick your budget, let me know what types of birds and any material preferences, and I will send you a mix of toys to suit - maybe even new ones specifically designed per your information!
You can also have this item delivered every month, every other month, or every 3 months .. Just choose your frequency before adding to the cart!
For the amount of toys, it will really depend on your selections. I wanted to make sure that these were as customizable as possible, so putting a set number of toys per tier doesn't work for all birds unfortunately. For instance the dinosaur toys are $15 a piece so if someone wants those and chooses $15 a month, then they will get 1 toy, but if they are more into balsa, yucca, etc, then that $15 might be 2 toys and some foot toys. The budget basically I use that as money to go "shopping" in my own store for your bird to maximize those funds as much as possible. I am a bargain shopper myself and like to make sure I am getting my money's worth - and that extends to the toy boxes too!
Hanging toys is basically a "catch all" for any type of toy that hangs and can be destroyed.
Foraging Toys are toys that are ideal for hiding a treat inside.
Foot Toys are toys meant to be played with on the ground, or put in a bowl, etc. They don't attach to the cage at all. Lots of birds like to play with their feet and these encourage that natural behavior.
Seasonal would be any toys that are usually holiday or season themed. I do toys for Christmas, Halloween, Valentine's Day, Easter, etc. These are only available for the relevant months.
Waste Knots come in Pine and Balsa and are the leftovers from cutting shapes.
Skewer Fillers are smaller toys that are designed to fit perfectly onto a stainless steel skewer to make up your own toy. They are also good as standalone toys for larger birds to use as foot toys, or for small shy birds.
Toy Parts are simply that; parts of toys, not made up into a toy, but that you could use as foot toys, or to make your own toys.
Critter Toys are toys for small animals like rabbits, rats, and hamsters.