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Tag Archives: green marketing
What Green Businesses Can Learn from Obama's Campaign
Posted on December 14, 2012 by dwigder
Although President Barack Obama ran a successful campaign and won a decisive electoral-college victory, the margin in key battleground states was slight. Indeed, a shift of 407,000 votes across four of them — Colorado, Florida, Ohio, Virginia — would have given Mitt Romney the 69 electoral votes he needed for victory.
Big data has been touted as key to Obama's victory — and securing winning margins in swing states — by enabling the campaign to focus scarce resources on voters who could be persuaded to vote for Obama and, once persuaded, were likely to actually vote.
Critical to this effort was the Obama campaign's recognition that voters may be demographically similar while at the same time strikingly different when it came to the issues that they cared about. As Dan Wagner, the campaign's chief analytics officer, told The Los Angeles Times, "White suburban women? They're not all the same. The Latino community is very diverse with very different interests. What the data permits you to do is figure out that diversity."
For the Obama campaign, a key to victory was to precisely understand which issue would be most persuasive to a voter's choice and then microtarget like-minded voters with messaging that relayed the President's stance on the issue and his action plan to address the issue going forward.
Underpinning this effort by the campaign was market research to determine the precise issue that most effectively influenced voter decisions — and which voters cared about which issues. The campaign also targeted known supporters, asking them to reach out to Facebook friends in swing states in hopes of influencing their voting decisions.
Such microtargeting is not limited to campaigns. Companies can also use this approach to identify and shape green brand preferences, and ultimately, purchase decisions. Here is how:
Focus on consumer persuadability. Politicians are known for boasting to voters about what they have done while in office and expecting voter support in return. This is similar to how many brands tout their green accomplishments today: more recyclable, safer chemicals, reduced material content. But, as in politics, such accomplishments may not be relevant to consumers, green or otherwise. Nor are they necessarily factors that influence brand preference and choice.
In contrast, the Obama campaign had a laserlike focus on the issues most associated with influencing voter decisions. Brands can learn from such an approach. By determining not only what consumers care about but also prioritizing messaging to focus on those needs most associated with consumer preference and choice, brands can have greater impact for a given investment. In each case, market research is required to reveal what cares or needs have the most influence on preference and choice and for which audiences.
Method's recent Clean Happy video campaign illustrates such an approach. The campaign targets household decision-makers and focuses on a broad range of consumer cares and needs and how Method's products deliver on each.
For example, one video titled "Clean Like a Mom" promotes Method household cleaning products that contain safer chemicals than traditional cleaners. But, instead of focusing exclusively on product attributes, the video highlights how Method products address specific consumer cares, namely, kids' safety and the desire by moms to be perceived by their peers as doing the right thing. Presumably, Method did market testing and found out that with moms, these issues motivated greater brand preference and choice than alternatives.
Interestingly, green marketers can effectively influence consumer behavior even if consumers do not consider themselves to be green. One dramatic example comes from a Yale University/George Mason survey that segmented Americans based on their attitudes toward climate change.
The survey revealed that two consumer segments — the one most alarmed by and the one most dismissive of climate change — were the most future-oriented in terms of their outlook. Such attitudinal similarities provide a potential opening for marketers to try a more future-focused message when selling greener products to these segments despite their polar opposite views on climate change.
Be true to your brand. Some politicians try to reinvent themselves in order to tell voters what they want to hear. Arguably, this is similar to a brand that wants to engage consumers on green issues but is not currently perceived in the market as being green.
Brands do not necessarily have to be known for being green in order to be relevant to consumers. Instead, brands should tell their story in a way that is true to their existing brand positioning.
Unilever's Axe is a great example. Known as an irreverent brand that uses the sex appeal of its products to drive sales, Axe launched its " Showerpooling" campaign to engage its customer base on the issue of water conservation. The platform uses showerpooling — sharing showers — not only as a way to grab attention, but to make it relevant with the audience. The campaign jokes: "It's not just environmentally friendly … it's all kind of friendly."
Target microsegments. The Obama campaign identified microsegments through research and projected these against a database of registered voters in a nationwide effort to influence voter choice. Of course, marketers could develop their own database by encouraging consumers to sign up for ongoing communications from a company.
But, even without a database, marketers can certainly target microsegments online. This can be done by targeting green consumers on contextually relevant sites, retargeting those visitors elsewhere online or by partnering with a demand side platform to identify and target audiences with like-minded profiles regardless of where they go online.
Turn loyalists into influencers. The Obama campaign successfully tapped its supporters to motivate friends in swing states to vote. Similarly, advertising campaigns should activate loyal customers to serve as influencers and advocates for the brand. Method deployed a similar approach in its recent campaign by distributing fun videos through social sites such as YouTube and Facebook and providing incentives for viewers to share them.
The Obama campaign demonstrated the power of microtargeting to influence voters, and arguably, affected the outcome of the election through this technique. Obama's success was bolstered by focusing on specific issues most influential with specific voters, rather than a more general message. Such a campaign provides many lessons for green marketers — as well as the opportunity to take a similar approach to drive adoption of green products.
Posted in Climate Change, Consumer behavior change, Consumer behaviors and beliefs, Green Consumer Demand, Green Consumerism, Green Marketing, Sustainable marketing, Targeting, Uncategorized	| Tagged big data, green consumerism, green marketing, microsegmentation, persuadability, sustainability communications, targeting green consumers	| 8 Replies
Pinterest Emerging as Promising Platform for Green Marketers
Over the past 12 months, Pinterest has witnessed explosive growth. The site has topped 23 million unique visitors and average site visit time is nearly 100 minutes per month, making it one of the largest and most engaging social networks around. AdAge raves that "…Pinterest has gone from relative obscurity to exalted status alongside Facebook and Twitter…"
What is so compelling about Pinterest is its simplicity, empowering users to capture, curate and share content of interest at the click of a button. Moreover, its format allows users to easily browse and discover new content pinned by other users.
Brands, including green brands, are increasingly discovering the potential of Pinterest and finding ways to adapt this consumer-centric platform for their benefit.
Promote discovery. Consumers like to browse Pinterest and, while doing so, are discovering brands. Brands are maximizing their chance of being discovered by finding ways to distribute their content on Pinterest.
One way to accomplish this is for brands to directly curate their own Pinterest content. Additionally, brands can make truly compelling content available online. This could include visually powerful images on relevant and timely themes that the growing number of Pinterest users may find and pin onto their personal boards. Consumers can discover content on their own or be encouraged through contests like the one that Method deployed to incentivize Moms to pin images of Method products.
Strengthen brand identity. Companies are also finding ways to leverage Pinterest to help define their brands. They do so by using the Pinterest platform to distribute content that brings to life their brands — or core values.
Whole Foods, for example, says they are committed to "selling the highest quality natural and organic products available". For Whole Foods, such a commitment originates in the garden where the food is grown and pays off through the appeal of the dish that is ultimately served and the healthier lifestyle to which the food contributes. Pinterest boards sponsored by Whole Foods bring each of these dimensions to life.
Highlight social responsibility. Pinterest can also enable brands to highlight its commitment to corporate social responsibility (CSR) in a very visible and compelling way. In addition to its other Pinterest initiatives, Whole Foods maintains a Pinterest board dedicated to the Whole Planet Foundation and its many initiatives sponsored around the world. Images map where contributions are made and illustrate the good works that are done in a format that seems, in many ways, less constrained or forced than the Corporate Social Responsibility tab on their corporate site.
Drive sales. Eco-friendly brands are also beginning to experiment with social networks to drive sales, and Pinterest is emerging as a key option. When looking at click-through rates to retail sites from the top three social networks — Facebook, Pinterest and Twitter — Facebook continues to drive the vast majority of traffic but Pinterest exceeds Twitter in terms of traffic generation. In fact, Pinterest is now responsible for more than 11 percent of user shopping sessions originating from the top social networks — Facebook, Twitter and Pinterest. Moreover, sales conversion rates for users originating from Pinterest are trending higher than from Twitter. At $169, the average order size of Pinterest users is substantially greater than for users that originate from either Facebook ($95) or Twitter ($71).
Brands like eBay are taking note, promoting eco-friendly products across a myriad of Pinterest boards, including health and beauty, fashion and electronics, and providing each product image with a direct link to a transaction page within the eBay Green site.
For green marketers, Pinterest provides a promising platform to engage consumers and for consumers to discover brands that they might not ordinarily interact with. Pinterest's unique format provides the opportunity for companies to show their brands to consumers in a visually powerful way. Such interactions can provide dimension to a brand and can potentially drive sales. Green brands will be missing a key emerging opportunity online if they fail to consider their own Pinterest strategy.
Posted in Brand engagement, Climate Change, Consumer behavior change, Eco-brands, Eco-friendly behaviors, environmental marketing, Green Brands, Green Marketing, Green Social Media, Green Web 2.0, Social media, Sustainable marketing	| Tagged green marketing, Green Social Media, green social platform, Pinterest	| 8 Replies


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IRELAND: ICCL calls for vaccine pass law to be scrapped
– Statement published by ICCL on 13 July 2021, available here.
The Irish Council for Civil Liberties (ICCL) says the new law introducing a vaccine pass system for indoor settings is discriminatory and should be scrapped. We have contacted Ireland's elected representatives asking them to oppose it.
Executive Director of ICCL Liam Herrick said:
"This legislation will write discrimination based on health status into our laws. It will also establish a system of health checks for access to goods and services with no clear objective or definite end date. Not only that, but it is yet another example of a government rushing through far-reaching legislation without allowing our elected representatives to properly debate it."
Since the Government introduced emergency powers for the Health Minister to deal with the pandemic, there have been numerous examples of government introducing ill-advised and poorly thought-out legislation. This Bill, which writes discrimination into law, will set a dangerous precedent. It has been developed without any meaningful consideration of equality and data protection concerns and presents a U-turn on previous Government commitments in pursuit of short-term economic gains.
The public health objectives behind the Bill are unclear. Originally, Government had implied the vaccine passports system would be a stopgap measure until a critical mass of the adult population were vaccinated. But already it is making references to extending this system into other indoor sectors, and potentially retaining the system as long as children remain unvaccinated.
The system is also likely to be unworkable. Are publicans and restauranteurs really going to ask customers and friends for private health data in order to refuse entry? Forgeries will be likely. Where an unworkable and unenforceable piece of legislation is introduced, it makes a mockery of our legal system.
The Government regularly cites its commitment to the principles of solidarity felt at the beginning of the pandemic. This proposal fundamentally damages that sense of solidarity. We went into this pandemic together, and we should come out of it together.
Read our letter to Minister Stephen Donnelly: https://www.iccl.ie/wp-content/uploads/2021/07/Letter-Donnelly-vaccine-pass-bill.pdf
The Irish Council for Civil Liberties (ICCL) is Ireland's oldest independent human rights campaigning organisation. We monitor, educate and campaign to secure human rights for everyone in Ireland.
For comment: Liam Herrick
For media queries: sinead.nolan@iccl.ie
IRELAND: CSOS call for the protection of the right to peaceful assembly during the pandemic
IRELAND: Government must protect peaceful and pandemic-safe protesters
GREEN VOICES: PUBLIC PARTICIPATION FOR CLIMATE ACTIVISTS
IRELAND: Interview with The Wheel – Civic actors were crucial to respond to the crisis
IRELAND: Criminal sanctions for organising gatherings ramain, critical social media posts surveilled
IRELAND: ICCL welcomes decriminalisation of restriction on movement and return to policing by consent
IRELAND: Call to include physically distant protest as a reasonable excuse to leave home
IRELAND: ICCL Letter to Garda Commissioner
IRELAND: Any extension of garda powers must undergo human rights vetting process
IRELAND: ICCL – Extraordinary police powers should not be used
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redpajama_set_name: RedPajamaCommonCrawl


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A.	"Article 10" was enacted in 2011 to be a portion of the New York State Public Service Law. It is a general state law that is applicable in all of New York State. Article 10 empowers the New York State Board on Electric Generation Siting and the Environment (Siting Board) to issue Certificates of Environmental Compatibility and Public Need (certificate) authorizing the construction and operation of major electric generating facilities.
A.	DPS has 30 days after the date of the applicant's submittal to make written comments on the adequacy of the Public Involvement Program plan. If deemed inadequate, DPS will make specific written recommendations as to what measures are necessary to make the Public Involvement Program plan adequate. Thereafter, the applicant has 30 days to consider the measures recommended by DPS and, in a final written Public Involvement Program plan filed with the Secretary, shall as to each specific measure either revise the Public Involvement Program plan to incorporate the DPS recommendation, or provide a written explanation as to why the applicant is not incorporating the DPS recommendation.
A.	The presiding examiner will award funds on an equitable basis to municipal and local parties who will use them to contribute to a complete record leading to an informed decision as to the appropriateness of the site and the facility and will facilitate broad participation in the proceeding.
A.	A written transcript record is made of the hearings and of all testimony taken and the cross-examinations thereon. In addition, the presiding examiner will provide a summary of the proceedings in a recommended decision that will be presented to the Siting Board. The parties will also present legal briefs to the Siting Board with citations to the portions of the record they deem relevant to their positions.


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4689 City and County of San Francisco Legislation Details File #: Version: 1 210503 Name: Ground Lease and Loan Agreement - Balboa Park
Housing Partners, L.P. - 100% Affordable Housing -
2340 San Jose Avenue - Ground Lease with Annual
Base Rent of $15,000 - Loan Not to Exceed
$24,459,458 Status: Type: Resolution Passed File created: In control: 5/4/2021 Clerk of the Board On agenda: Final action: 6/17/2021 Enactment date: 6/17/2021 278-21 Enactment #: Title: Resolution 1) approving and authorizing the Director of Property and the Mayor's Office of Housing and Community Development ("MOHCD") to enter into a Ground Lease for Real Property owned by the City and located at 2340 San Jose Avenue ("Property") with the Balboa Park Housing Partners, L.P. ("Developer") for a lease term of 75 years and one 24-year option to extend and an annual base rent of $15,000 ("Ground Lease") in order to construct a 100% affordable, 131-unit multifamily rental housing development affordable to very-low and low-income households, with 39 units set aside for HOPE SF residents voluntarily relocating, and 10,791 sq. ft of commercial space, with an early childhood education center, community space and resource center, community bike space, and two additional spaces for public benefit purposes or community-serving purposes (the "Project"); 2) approving and authorizing a Loan Agreement in an amount not to exceed $24,459,458 for a minimum loan term of 57 years ("Loan Agreement") to finance the development and construction of the Project; 3) approving and authorizing a Declaration of Restrictions and Reservations of Easements between the City, the San Francisco Bay Area Rapid Transit District ("BART"), and the Developer for $0 for a no-build area to benefit the Project ("No-Build Easement"); 4) approving and authorizing an Easement Agreement between the City and BART for $0 to relocate an existing storm drain lateral ("Storm Drain Easement"); 5) adopting findings that the Project and proposed transactions are consistent with the General Plan, and the eight priority policies of Planning Code, Section 101.1; and 6) authorizing the Director of Property and/or the Director of MOHCD to execute the Ground Lease, Loan Agreement, No-Build Easement, and Storm Drain Easement, make certain modifications to such agreements, as defined herein, and take certain actions in furtherance of this Resolution, as defined herein. Sponsors: Mayor, Ahsha Safai Attachments: 1. Leg Ver1, 2. DRAFT Ground Lease, 3. DRAFT Dec of Restrictions & Reservation of Easements, 4.
DRAFT Storm Drain Easement Agrmt, 5. DRAFT 2nd Amended & Restated Promissory Note, 6.
DRAFT Amended & Restated Loan Agrmt, 7. DRAFT Dec of Restrictions & Affordable Housing
Covenants, 8. DRAFT Deed of Trust, 9. RFQ 041116, 10. PLN Gen Plan Ref 051917, 11. PLN Ntc of
Final Approval 101118, 12. Form 126 - Ground Lease, 13. Form 126 - Loan Agrmt, 14. Pres Action
Memo 052021, 15. BLA Rpt 060321, 16. Comm Pkt 060321, 17. Comment Ltr, 18. MOHCD
Presentation 060321, 19. Comm Rpt Rqst 060321, 20. Board Pkt 060821, 21. Post-Packet Comm
060821, 22. Leg Final, 23. Form 126 Final (Ground Lease), 24. Form 126 Final (Loan Agreement)
Action By Date Action Result Ver. RECEIVED AND ASSIGNED President 5/4/2021 1 TRANSFERRED President 5/20/2021 1 REFERRED WITHOUT
RECOMMENDATION AS AMENDED AS
A COMMITTEE REPORT Government Audit and Oversight
Committee 6/3/2021 1 Pass ADOPTED Board of Supervisors 6/8/2021 1 Pass APPROVED Mayor 6/17/2021 1


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Cardiology > Prevention
HTN Targets in Spotlight at AHA Sessions
SPRINT results slated for release at conference
by MedPage Today Staff November 06, 2015
The Systolic Blood Pressure Intervention Trial (SPRINT) will again be in the spotlight with full presentation of the data at the American Heart Association meeting in Orlando this week.
Topline results released in September suggested an almost 25% reduction in mortality and 30% reduction in a composite of myocardial infarction, acute coronary syndrome, stroke, heart failure, or cardiovascular death with a systolic target under 120 compared with less than 140 mm Hg for middle age and older adults.
"SPRINT is the obvious biggie that will lead all discussions," Christopher Cannon, MD, of Brigham and Women's Hospital in Boston, told MedPage Today.
Conference co-chair Frank Sellke, MD, chief of cardiothoracic medicine at Brown University's Rhode Island Hospital in Providence, agreed that the trial both because of its size (9,361 hypertensive patients 50 years of age or older) and sponsor (the National Heart, Lung, and Blood Institute) would be influential.
"It may actually change some guidelines," he told MedPage Today.
However, details have been anxiously awaited, particularly for these key questions:
Total number of deaths and how big was the reduction in cardiovascular mortality to indicate how meaningful the findings were
How much did the softer endpoints of ACS and heart failure contribute to the primary composite endpoint
The possible impact of the trial being stopped early and the risk profile of the population, which will dictate generalizability
Possible reasons why the more intensive strategy worked in SPRINT but not in diabetes in the ACCORD trial
SPRINT will be presented at a special late-breaking clinical trial session on Monday, Nov. 9.
At the late-breaking trial session immediately prior to SPRINT, 2-year data on the CT Surgery Network Severe MR Trial will be presented.
One-year data from that trial presented at the AHA meeting in 2013 had suggested surgical replacement and transcatheter repair for severe mitral regurgitation were largely equal for clinical outcomes, although regurgitation returned substantially more often with the catheter-based approach.
While that difference in regurgitation recurrence didn't impact mortality at 1 year, cardiac surgeons had noted there could be repercussions down the line.
"I'm very interested in what happens at 2 years," Michael Acker, MD, of the University of Pennsylvania, said when presenting the data in 2013. "My gut is because there is no reverse remodeling at 1 year, we will start to see a clinical signal if we follow these patients longer."
Others have suggested it could take 5 or 10 years of follow-up to really be sure, but "2 years is better than 1," said Sellke, who noted his role as data safety monitoring board chair. "I think a lot of valuable information will be presented."
Sellke also highlighted data to be presented from the PRADA trial attempting cardioprotection during adjuvant breast cancer therapy and the randomized Resuscitation Outcomes Consortium CCC Trial of continuous versus interrupted chest compressions for out-of-hospital cardiac arrest.
Cannon also pointed to a subanalysis of the DAPT trial delving into individualizing treatment duration for dual antiplatelet therapy and phase III ANNEXA-R data on andexanet alfa, an antidote for the direct factor Xa inhibitors -- in this case, for reversing rivaroxaban in older adults.
The trial only looked for biochemical measures of anticoagulation reversal and safety in healthy volunteers, whereas the FDA is likely to require at least some clinical treatment data as for the first reversal agent idarucizumab (Praxbind, for dabigatran [Pradaxa]) approved last month.


Many people who go through cancer treatment worry about hair loss. While it may be a side effect of some treatments, it does not happen to everyone. Some treatments are less likely to make your hair fall out. Even with the same drug, some people lose their hair and some do not. Your health care provider can tell you how likely it is that your treatment will make you lose your hair.
Many chemotherapy drugs attack fast-growing cells. This is because cancer cells divide rapidly. Since the cells in hair follicles also grow rapidly, cancer drugs that go after cancer cells often attack hair cells at the same time. With chemo, your hair might get thinner, but not all fall out. You also may lose your eyelashes, eyebrows, and pubic hair.
Like chemo, radiation goes after fast-growing cells. While chemo can cause hair loss all over your body, radiation only affects the hair in the area being treated.
Hair loss mostly happens 1 to 3 weeks after the first chemo or radiation treatment.
The hair on your head may come out in clumps. You will probably see hair in your brush, in the shower, and on your pillow.
If your provider has told you treatment may cause hair loss, you might want to cut your hair short before your first treatment. This could make losing your hair less shocking and upsetting. If you decide to shave your head, use an electric razor and be careful not to cut your scalp.
Some people get wigs and some cover their heads with scarves or hats. Some people do not wear anything on their heads. What you decide to do is up to you.
If you think you will want to have a wig, go to the salon before your hair falls out so they can set you up with a wig that matches your hair color. Your provider may have names of salons that make wigs for people with cancer.
Try different wig styles to decide what you like best.
If you want, you can also try a different hair color. The stylist can work help you find a color that looks good with your skin tone.
Find out if the cost of the wig is covered by your insurance.
Scarves, hats, and turbans are comfortable options.
Ask your provider if cold cap therapy is right for you. With cold cap therapy, the scalp is cooled. This causes the hair follicles go into a state of rest. As a result, hair loss may be limited.
Wear soft material next to your skin.
On sunny days, remember to protect your scalp with a hat, scarf, and sunblock.
In cold weather, do not forget a hat or head scarf to keep you warm.
If you lose some, but not all of your hair, there are many ways you can be gentle with the hair you have.
Wash your hair two times a week or less.
Use gentle shampoo and conditioner.
Pat your hair dry with a towel. Avoid rubbing or pulling.
Avoid products with strong chemicals. This includes permanents and hair colors.
Put away things that will put stress on your hair. This includes curling irons and brush rollers.
If you blow-dry your hair, put the setting at cool or warm, not hot.
It may take a while to adjust to not having hair. Lost hair may be the most visible sign of your cancer treatment.
If you feel self-conscious about going out in public, ask a close friend or family member to go with you the first few times.
Think ahead about how much you want to tell people. If someone asks questions you do not want to answer, you have the right to cut the conversation short. You might say, "This is a hard subject for me to talk about."
A cancer support group might help you feel less alone knowing that other people are going through this too.
Hair often grows back 2 to 3 months after your last chemo or radiation treatment. It may grow back a different color. It may grow back curly instead of straight. Over time, your hair may go back to the way it was before.
When your hair starts to grow back, be gentle with it so it can get strong again. Consider a short style that is easy to care for. Continue to avoid things like harsh dyes or curling irons that can damage your hair.
American Cancer Society website. Hair loss. www.cancer.org/treatment/treatments-and-side-effects/physical-side-effects/hair-loss.html. Updated June 8, 2015. Accessed December 17, 2018.
American Cancer Society website. Cooling caps (scalp hypothermia) to reduce hair loss. www.cancer.org/treatment/treatments-and-side-effects/physical-side-effects/hair-loss/cold-caps.html. Updated April 19, 2017. Accessed December 17, 2018.
Pappas-Taffer L, Lee K, Higgins HW, Robinson-Bostom L, McDonald CJ. Dermatologic toxicities of anticancer therapy. In: Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE, eds. Abeloff's Clinical Oncology. 5th ed. Philadelphia, PA: Elsevier Saunders; 2014:chap 44.
Updated by: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.


Royal Street Hotel 3 stars is situated on Deribasovskaya Street 27 in Primorsky district of Odessa in 67 m from centre. Hotel is right near of Arab Cultural Centre, Chernomorets Stadium, Saint Panteleimon Monastery. That is ideally appropriate for family, business, luxury, city trip, shopping, romance/honeymoon vacation. The nearest Odessa International Airport is situated in 7.8 km from the hotel.
Most popular services: parking space, car hire, hiking, you may order food and drinks into the room, designated smoking area, special non-smoking rooms, convenient airport transfer, internet services, 24/7 reception. Cards accepted at this property: Visa, Mastercard, Maestro.
For comfortable accommodation guests can choose one of the 6 rooms in hotel. Guests can choose from different types of rooms: suite, double. We offer the facilities such as free toiletries, hairdryer, telephone, minibar, clothes rack, refrigerator, flat-screen tv.
Any noise will not bother you, because we offer soundproofing in suite. You will like city look and landmark view from your window.
Bright room with a flat-screen TV, a work desk, and a private bathroom.
Bright room with a flat-screen TV, a work desk, and a private bathroom. This spacious room features a stylish shower cubicle.
Bright room with a flat-screen TV, a work desk, and a private bathroom. This large room offers a bathtub and a bidet.
Bright room with a flat-screen TV, a work desk, and a private bathroom. This room has no capacity for extra beds/cots.
Bright duplex features 2 rooms, a flat-screen TV, and a private bathroom. Please note that the price is based on 2 guests. Maximum occupancy is 6 (see Hotel Policies).
Bright room with a flat-screen TV, a work desk and a private bathroom. This very large room features a balcony and a living room.
Parking Private parking is possible at a location nearby (reservation is not needed) and costs UAH 100 per day.
Children and Extra Bed Policy All children are welcome. All children under 12 years are charged UAH 290 per night for extra beds. All further older children or adults are charged UAH 290 per night for extra beds. The maximum number of extra beds in a room is 1.
Please note that early check-in and late check-out cost 50% of 1 night.
Nice and good staff. Perfect location. Clean Room.
Very small room. Busy reception, always with a line.
I especially liked the value. The room was larger than most and quite comfortable for inviting guests. The bedroom is in a separate room from the living room which had a large couch.


I want to focus our thinking by reading Hebrews 12:1-3.
In modern America, in the church, we have taken much of the brutality and violence out of Jesus' crucifixion.
Crucifixion was a common method for executing people who were not Roman citizens.
Jesus and the two thieves who were crucified on the same occasion were only three of hundreds of first century Jews crucified by the Romans.
Nor was this method of execution used by the Romans only with Jewish people--it was a common means of execution by the Roman troops.
It was a very violent, brutal, cruel way to die.
Twentieth and twenty-first century Christians have removed much of the violent brutality and cruelty from Jesus' crucifixion.
We tend to be much more comfortably focusing on artist's renditions of the crucifixion which are "pretty" but not violent or cruel.
We know Jesus suffered when he died, but we much prefer to focus on his enormous love rather than his real suffering.
Many of us are just plain shocked when we are confronted with the violence and cruelty of Jesus' execution.
It was a brutal execution witnessed by a crowd of onlookers, much like the crowds that witnessed hangings in our western movement.
It was a contemptible, disgraceful way to die--the intent was to disgrace the execution victim by destroying his humanity in death.
A question I asked myself for many years was this: "How did Jesus do it?"
He made no physical attempt to avoid it when he knew before the event it would occur.
In fact, he consciously did the things he knew would lead to crucifixion.
He knew it would involve enormous suffering.
Yet, he did not run, did not hide, did not defend himself.
How is it possible to do that when you are not guilty of anything?
The "how" is addressed at least twice in New Testament writings.
One is given in 1 Peter 2:23.
And while being reviled, He did not revile in return; while suffering, He uttered no threats, but kept entrusting Himself to Him who judges righteously.
As Jesus endured enormous injustice in his death, he used his strength to focus on being [in suffering!] the person God wanted him to be.
He did not have the strength [nor do we!] to focus in suffering on the injustice and on being the person God wanted him to be.
So he entrusted the injustices to God to let God care for them.
He just focused on being the person God wanted him to be--he did not let injustice distract him!
That is one of the "hows!"
The other "how" is given in the reading we shared at the beginning (Hebrews 12:1-3).
That "how" was this: he was motivated to endure the cross and despise the shame for the sake of the joy in front of him.
Our reaction is, "Joy? What joy? What possibly could be worth going through that experience?"
For a moment, I want you to focus on joy.
"What joys did Jesus know that were ahead of him that made the experience of crucifixion endurable?"
I am certain I do not know all of them.
Being the means through which God's promise made much more than a thousand years earlier was kept.
Being enthroned by God on God's right hand (kingly language).
Being made Lord of lord's and King of kings by God Himself.
Interceding for every man or woman who trusts him and his death.
Here are my questions to us.
If Jesus found joy in being our ransom by giving his blood for our redemption, do we find joy in being ransomed?
If Jesus found joy in becoming our Savior, do we find joy in being saved?
If Jesus found joy in making our forgiveness a permanent reality, do we find joy in being forgiven?
If Jesus found joy in the right to intercede for us, do we find joy in realizing that is what he does for us every day of our lives?
How do we respond to this great gift provided in the brutality of his execution? Surely, in many ways. Yet, one of those ways that must not be absent is with joy! Our joy to be alive in Christ must be real and must be expressed! How do you express this joy?


Just because you're managing a WordPress site, doesn't mean you can't take advantage of the awesome VueJs library. To get the most out of the library, you typically want to use some kind of build tool. However, sprinkling some interactivity in your front end is relatively easy.
Let's take a look at how we can embed a Vue component into one of our WordPress pages.
Setting up a WordPress application is relatively easy now a days. There are tons of hosting companies that offer one click WordPress installs with easy hosting setup. The install is outside the scope of this article. However, once installed and running, its incredibly easy to add dynamic Vue components to any Gutenberg Block.
Once you're ready, create your Custom HTML Gutenberg block.
Here is the script. This example is copied from the VueJs official docs. We'll then go over the code.
We first need to import our Vue library using the CDN script. We then have our markup which simply interpolates and displays the data in the message property. Finally our script section where we instantiate our Vue instance. In that instance, we set the data property method, and it's message property. We also call a console log when the component is mounted. Pretty simple.
Save or preview your WordPress page and you should see the message "Hello Vue-WordPress!" displayed on the page.
It's as simple as that. Let's add a bit more functionality by making an HTTP request from our Vue Instance.
We've now imported the Axios request library as well. Let's look at some of the additions to our code.
We then add the methods property to the Vue instance. and create a method called makeApiRequest which is responsible for using the Axios library to make the GET request to the remote API. In this case, we are using the JSON place holder API available here.
Notice we are using arrow functions, which is gaining adoption in most modern browsers. The response data is assigned to the users property. We make sure to catch and deal with any errors. Finally, we can look at the markup, where we use the v-for directive to loop over the contents of the users array.
That is all we need in order to implement some VueJs goodness into our WordPress pages and posts.
Of course, since we dont have the functionality that a build tool offers us, we have to limit our use of VueJs to small to medium micro applications. However, as long as one can manage the code effectively, there is no limit to what they can do.
Check back soon for new updates and recipes.


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The manuscript is included in the British Library's new online resource Discovering Literature: Shakespeare, launched this month with around 300 digitized items related to the Bard. They include a 16th-century pamphlet on witchcraft, a cast of a Michelangelo bust of Brutus, a self-portrait by Elizabethan magician John Dee, 19th-century costume recommendations for Hamlet, and even some illustrations of the "strangers" of Shakespeare's day, like a painting of a "Virginian Indian" — one of the American Indians brought to England and exhibited as oddities in the 17th century. The objects are joined by essays exploring themes in Shakespeare's writing, such as "Richard III and the staging of disability" by Katherine Schapp Williams and "Ophelia, gender and madness" by Elaine Showalter.
The manuscript of Shakespeare's handwritten Sir Thomas More speech is on view through March 27 in Shakespeare, Life of an Icon at the Folger Shakespeare Library (201 East Capitol Street, SE Washington, DC), and will be on view in Shakespeare in Ten Acts at the British Library (96 Euston Road, London) from April 15 to September 6.


text:
Central Avenue – stacja metra nowojorskiego, na trasie linii BMT Myrtle Avenue Line. Znajduje się u zbiegu alei Myrtle Avenue z ulicą Cedar Street w dzielnicy Bushwick w okręgu Brooklyn, w Nowym Jorku i jest obsługiwana przez pociągi linii M. Została otwarta 19 grudnia 1889.

Linki zewnętrzne

Przypisy

Stacje metra w Brooklynie

redpajama_set_name: RedPajamaWikipedia


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Why didn't Harry's wand prevent Voldemort from trying to kill him in the graveyard?
I was just watching Goblet of Fire and remembered something Voldemort said in The Deathly Hallows-1. He said that "My wand and Potter's share the same core. We can wound but not fatally harm one another". But in the graveyard, he was able to torture Harry and tried to kill him using AK, and Harry's wand did nothing. Why so? Also, since it was Voldemort dueling Harry, Harry's wand should have done that golden flames thing to prevent Voldemort from killing or torturing Harry, but it didn't. Is there an explanation for this?
harry-potter wandlore
mayank budhwanimayank budhwani
It did
Since you mention a quote from the film version of Deathly Hallows, I shall mostly focus on the movies.
In the film Harry Potter and the Deathly Hallows: Part 1, Voldemort does indeed say that he can harm Harry with his wand, but not kill him:
VOLDEMORT: But I face an unfortunate complication. My wand and Potter's share the same core. They are, some ways, twins. We can wound but not fatally harm one another. If I am to kill him ... I must do it with anothers wand.
In the original novel, the scene is a little different:
"As I was saying," continued Voldemort, looking again at the tense faces of his followers, "I understand better now. I shall need, for instance, to borrow a wand from one of you before I go to kill Potter."
The faces around his displayed nothing but shock; he might have announced that he wanted to borrow one of their arms.
"No volunteers?" said Voldemort. "Let's see . . . Lucius, I see no reason for you to have a wand anymore."
Lucius Malfoy looked up. His skin appeared yellowish and waxy in the firelight, and his eyes were sunken and shadowed. When he spoke, his voice was hoarse.
"My Lord?"
"Your wand, Lucius. I require your wand."
This is partly because of Priori Incantatem. If two spells from wands that share a core collide, a battle commences between the two wielders, with the stronger of the two forcing the weaker to recapitulate in ghostly form the spells it has cast:
"So what happens when a wand meets its brother?" said Sirius.
"They will not work properly against each other," said Dumbledore.
"If, however, the owners of the wands force the wands to do battle . . . a very rare effect will take place. One of the wands will force the other to regurgitate spells it has performed — in reverse. The most recent first . . . and then those which preceded it. . . ."
This is why Voldemort needed to use Lucius's wand in the book continuity: if he and Harry had tried to cast spells at each other, they might have connected, rendering Voldemort's spell ineffective and preventing him from effectively casting others.
The movie continuity seems to imply something different: that Priori Incantatem will only occur when Voldemort tries to kill Harry. Regardless, it seems likely that Voldemort is talking about the effect that occurred in Goblet of Fire, as opposed to an entirely new perk of having twin cores.
In any case, when he tried to kill Harry in the graveyard, he was unable to kill him. The first Avada Kedavra he cast missed, and the only one that could have hit was blocked by Priori Incantatem
Why didn't it shoot golden fire?
This was an entirely separate effect.
Voldemort did not completely understand the nature of the connection between him and Harry. Even when he used Lucius's wand, the connection between him and Harry still protected the latter. From the screenplay:
VOLDEMORT: Avada...
Abruptly, Harry's arm rises as if on a string, drawn up by the wand trembling in his hand. GOLD FIRE spits forth and -- Crack! -- SPARKS skitter up the chassis of the motorbike. Harry wheels and -- for a split second -- is face to face with Voldemort, whose eyes drift, staring -- with something like fear -- at Harry's wand. Then -- whoosh! -- Voldemort peels back.
The book describes the reason for this in more detail.
"I believe that your wand imbibed some of the power and qualities of Voldemort's wand that night, which is to say that it contained a little of Voldemort himself. So your wand recognized him when he pursued you, recognized a man who was both kin and mortal enemy, and it regurgitated some of his own magic against him, magic much more powerful than anything Lucius's wand had ever performed. Your wand now contained the power of your enormous courage and of Voldemort's own deadly skill: What chance did that poor stick of Lucius Malfoy's stand?"
"But if my wand was so powerful, how come Hermione was able to break it?" asked Harry.
"My dear boy, its remarkable effects were directed only at Voldemort, who had tampered so ill-advisedly with the deepest laws of magic. Only toward him was that wand abnormally powerful. Otherwise it was a wand like any other . . . though a good one, I am sure," Dumbledore finished kindly.
When Dumbledore say "that night," he refers to when Harry and Voldemort's wands connected. At the time of the event mentioned in the question, Harry and Voldemort's wands had not yet experienced Priori Incantatem. Not having "imbibed" Voldemort's power, Harry's wand could not use it against him.
AdamantAdamant
Wands aren't sentient; it can't do anything to actively "protect" Harry.
However when used against each other, this is when the "protection" occurs. Regardless of the spell used, the Priori Incantatum spell is created by creating a (seemingly kinetic) bond of energy between the two wands, causing the spells used previously to be negated.
When a duel occurred between wizards with wand cores harvested from the same creature, simultaneous spell-casting by both parties would trigger a rare, powerful effect called Priori Incantatem. Both wands became linked through a single, golden thread of energy. Hundreds of smaller golden beams shot off from this central thread to form a cage around the duellers.
What's required for this is for both users to cast a spell at each other (deflecting a spell doesn't count); and for them to cast the spells at the same time.
As for the Cruciatus Curse, it's a torturing spell - not something that would really be considered "mortally wounding". I.e. The Longbottoms were driven mad by the pain, but they are still otherwise alive and well. Additionally, I really don't believe that Voldemort wanted to really really hurt Harry using the Cruciatus Curse - he just wanted to see him squirm.
BenBen
Your first statement that wands aren't sentient is not exactly true. The wand chooses the wizard. Also, a wand will not perform well for you unless you win its allegiance. Apart from this, Harry's wand produced a spell all on its own to destroy Lucius' wand which was being wielded by Voldemort in DH. Wands are sentient to a some extent.
– ʀᴇᴅ_ᴅᴇᴠɪʟ226
Not the answer you're looking for? Browse other questions tagged harry-potter wandlore or ask your own question.
Why did Harry not repair his wand in the movie?
Did Voldemort know that his wand's core came from Fawkes?
Did Harry's wand choose him because of Voldemort's power in him?
How did Voldemort know Lily didn't have her wand?
What was the spell Harry cast in the Battle of the Seven Potters?
Why didn't Voldemort begin searching for the Elder Wand much earlier on?
Why did Hermione grab Harry's wand?
The core of Voldemort's wand came from Fawkes, so how could he successfully use a Killing Curse against Fawkes?
Why didn't Voldemort just switch back to his old wand?
Did Dumbledore intend Voldemort to get the Elder Wand from Snape, without killing Snape, and without Voldemort realising that he wasn't its master?


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CellProthera
Key steps / Milestones
Treatment procedure
Clinical results
Experts' point of view
The clinical use of immunoselected CD34+ stem cells has been assessed in a Proof of Concept trial to evaluate their regenerative capacity in patients suffering from severe AMI. Seven patients have been included into the program initiated in January 2003. The life expectancy of these patients was lower than 3 years due to the severity of their infarct. Three of the patients were candidate for heart transplant at the time of their inclusion.
Following their informed consent, each patient was administered GCSF for 6 days before collecting by leukapheresis their blood stem cells which were then immunoselected in the Cell Therapy Center. The injection of the graft cells was performed directly into the myocardial lesions within 24 hours after sampling during a coronary bypass surgery.
In addition to the feasibility and the perfect tolerability of the graft cell injection, the clinical benefit shows tissue regeneration as well as tissue revascularization within scar tissue which was clearly documented by PET Scan.
After recent AMI
infarcted zone
6 months after stem cells grafting
Mycocardial regeneration
Such imaging technique using labeled products like glucose and ammonium allow the quantification of functional recovery (regeneration of myocardial tissue) and also the revascularization of myocardium after cell graft.
The necrotic area after AMI does not fixed glucose or ammonium and therefore is not any longer visualized providing a lacuna image on the PET Scan. When the myocardium has initiated its regeneration it become again visualized by fixing labeled ammonium and glucose.
From a clinical standpoint, the myocardial regeneration translated into a progressive improvement of the infarcted zone contractility leading to a parallel improvement of the global cardiac function as illustrated by a reduction of the observed cardiac dilatation and a concomitant significant increase in the left ventricular ejection fraction (LVEF). The LVEF corresponds to the ratio between the systolic ejection volume (ventricular volume when emptied after myocardium contraction) and the diastolic volume (full volume). This a key measure to assess the cardiac muscle function.
For a normal subject LVEF is over 70%. The patients included in the study had a LVEF lower than 35%, clearly indicating the presence of a severe heart failure.
The measurements of the LVEF after cell graft revealed a progressive and prolonged significant improvement up to +43 points (an 160% increase) compared to the pretreatment assessments
Most of the treated patients with cell graft experience a nearly normal life with for some of them a follow-up period exceeding now 13 years.
None of the three patients initially awaiting a heart transplant is any longer requiring such therapy, and, with the additional benefit of no immunosuppressive therapy as the cell graft was prepared from their own cells (autologous stem cells).
Although a number of therapies have proven to improve the cardiac function of a damaged heart, no currently available treatment with the exception of CellProthera has demonstrated an ability to generate myocardial tissue within the scarred regions of a heart underlying the truly innovative character of its therapeutic approach.
Grant agreement No 806595


text:
Fatal Shooting
19-year-old man dead after party in Columbia Sunday morning
Jun 6, 2021 1:03 PM EDT
Lindsey Goodwin,
COLUMBIA (WOLO): A 19-year-old man is dead after a party in Columbia early Sunday morning. Richland County Sheriff's deputies were called to the scene at the 1000th block of Lawhorn Drive around 12:30 a.m. for reports of a shooting. The man was found dead on scene and had been shot in the upper body. The incident is currently under investigation….
RCSD investigating a homicide after a man is found unresponsive in a car with bullet holes in it
The Richland County Sheriff's Department is investigating a fatal shooting after they found a man unresponsive in a car that had bullet holes in it.
RCSD investigating shooting on Kathleen Drive that left a man dead
The Richland County Sheriff's Department is investigating a shooting on Kathleen Drive that led to the death of a man on Thursday night.
Police identify murder suspect from shooting at the Colony Apartments last week
The Columbia Police Department is looking for a suspect accused in a fatal shooting last week at the Colony Apartments.
Coroner releases ID of Colony Apartments shooting victim
Richland County Coroner Naida Rutherford released the identity of the victim of a fatal shooting that took place this weekend at the Colony Apartments.
Man dead after shooting outside Colony Apartments
COLOMBIA (WOLO): One man has died after a shooting incident outside the Colony Apartments Saturday evening. Columbia Police say deputies were called to the scene shortly before 6 p.m. The victims are males and one has died, according to police. Investigators are on scene. We will update this story when we get more information. If you have any information regarding…
Richland County Coroner releases identity of man shot and killed at the Capri Apartments
Richland County Coroner Naida Rutherford is releasing the identity of man who was shot and killed at the Capri Apartments late Tuesday night.
CPD: No charges filed in shooting at Capri Apartments, investigators determine it was self-defense
The Columbia Police Department says that no charges will be filed in the Tuesday night shooting at Capri Apartments that left one dead. Police say their investigation led them to determine that the shooting fell under self-defense.
Lexington, Local News
Lexington County Coroner identifies victim from fatal shooting on Luke Street
May 7, 2021 6:39 PM EDT
Lexington County Coroner Margaret Fisher released the identity of a man who died Thursday after a shooting at approximately 12:15 p.m. on Luke Street.
Local News, Sumter
Sumter PD: Four individuals facing charges related to fatal shooting on Friday
Apr 14, 2021 6:21 PM EDT
The Sumter Police Department says two men have been charged with murder and two others are facing accessory charges in connection with a fatal shooting on Broad Street Friday.


The virtual machine grub file didn't actually have any password in the grub file, so I tested the function to dump all lines starting with set. Here is a screenshot of the same.
Would be good to add the credit to the database as well.
Database as in, the name of the file from which the password was gathered?
Storing credentials in the database should only be performed if the credentials are parsed appropriately.
Parsing the grub config is not as simple as splitting by whitespace. For this reason, the lazy option of simply matching and printing every line beginning with /password/i is far easier.
Also, private_type: :password is reserved for instances where the clear text password is stored. GRUB passwords can be hashed or encrypted, in which case private_type: :nonreplayable_hash is appropriate.
You are right, I was faced with the same challenge. I'll research GRUB for various configuration formats!
Also, if you go that route, then a better approach exists for your loop.
Instead of shoving everything in a loop and using a found variable, then relying upon it at the end, you can instead build up a Hash of credentials ([username] / <private> / <private_type>). Then, once all files have been parsed, you can iterate through the Hash, storing each credential in the database, and building a pretty table for output to console.
@bcoles I see that there's a delayed label. What kind of improvements are you looking for, perhaps I could assist?
The module should be updated with appropriate parsing for the extracted password.


Practice-based research in art and design is only partially amenable to discursive explication. In an educational framework that relies on notions of master/student relationships, in which the former is supposed to pass knowledge on to the latter, this fact often creates anxieties for both. From Jacques Rancière's point of view, the master's ignorance is important for the student's emancipation. In his book on The Ignorant Schoolmaster, Joseph Jacotot, he claims that learners become emancipated through their own activities of observing, retaining, repeating, verifying, doing, reflecting, taking apart and combining differently. In support of this method of the riddle, the supervisor can teach best by not knowing the subject matter but, instead, providing positive constraints to help keep the researcher on her own path, acknowledging that no two orbits are alike. For any researcher to be able to discover anything new, she has to learn the different languages of theories, things and media. The foundation of such knowledge is, however, not the supervisor/master. Her role, in contrast, is to claim the equality of each intelligent being, to discourage false modesty in students, and to encourage them to make discoveries through experiment and experience: to be attentive and use their own intelligence. For this to happen, master and student need a thing in common that establishes an egalitarian intellectual link between them. In practice-based research in design and art, the thing in common emerges largely through non-discursive media and modes of thought. Here, what can be seen, what can be thought about it, and what it can mean is also matter of translation, which Walter Benjamin, in The Task of the Translator, described as a mutually complimentary relationship between the languages of original and translation. No language in itself can give form to truth – and the task of a translation is to reveal what remains repressed in the original. In the many forms of translation involved in creative-practice research, candidate and supervisor work 'between the lines', in the interstices between the unknown and known, translating and re-translating. This paper explores, drawing on concepts by Benjamin, Rancière, Dewey, Wittgenstein and Kleist, which aspects help or prevent a situation in which students can respond to someone speaking to them, rather than examining them, under the sign of equality.


text:
What's the opposite of a rubber-stamp?
WHAT'S THE OPPOSITE OF A RUBBER-STAMP?…. Senate Pro Tempore Robert Byrd (D-W.Va.) has noticed that the White House has appointed a series of policy "czars" in the Obama administration cabinet, covering issues as diverse as healthcare and climate change. Byrd has also noticed that these "czars" don't need Senate confirmation and may be protected, in theory, by executive privilege.
And he's not happy about it.
"Too often, I have seen these lines of authority and responsibility become tangled and blurred, sometimes purposely, to shield information and to obscure the decision-making process," Byrd wrote in the letter.
"As presidential assistants and advisers, these White House staffers are not accountable for their actions to the Congress, to cabinet officials, and to virtually anyone but the president," he continued. "In too many instances, White House staff have been allowed to inhibit openness and transparency, and reduce accountability."
Byrd also urged the president to prohibit the right of executive privilege from appointees' in agencies overseen by the Senate.
Two quick things. First, Byrd is probably right. The "czars" operate, as practical matter, as heads of offices that sort of look like presidential taskforces. Obama has vowed transparency and accountability, and I suspect he means it, but this current mechanism could be improved to satisfy the needs of congressional oversight.
And second, good for Byrd for calling Obama out on this. Congress is … what's the phrase I'm looking for here … an independent branch of the government. The concept of oversight was effectively banished from 2001 to 2006, and the "rubber-stamp" phenomenon took hold. Congressional Republicans simply did what Bush and Cheney told them to do. It led to almost comical levels of secrecy and abuse, with no accountability at all.
I don't doubt the new majority party will work with the White House on the president's agenda. They're largely on the same page, have the same goals, and are content to let Obama take the lead in establishing priorities. All of that's fine. In a time like this, I'm thrilled there's a president and a Congress ready to work together on an ambitious policy agenda.
But checks and balances still count, and Congress still has oversight responsibilities. It's good of Byrd to remember that.


It is clear that your pain needs a professional work up. Sometimes a simple UTI can cause pain.
I doubt it is a brain cancer but it might be ingrowing toe nails - I have found that when they TURBT me without anaesthetic it makes my toes curl - perhaps the nerves work the other way around too!
Alternatively it could be NSU or a number of STDs.
I doubt it is bladder cancer as I doubt it is any other type of cancer but a good Doctor and a flexi will soon help.
Good luck, but never try self diagnosis on Mondays as it is always worse than self diagnosis on Friday afternoons!
I think you may have a brain tumor if anything.


text:
Photo Gallery -
Society -
Websites -
C1232 (Highland)
From Roader's Digest: The SABRE Wiki
Location Map ( geo)
No pictures uploaded (Upload?)
From: Balmacara (NG806273)
To: Kyle of Lochalsh (NG760272)
Distance: 5.1 miles (8.2 km)
Meets: A87, C1221, A87
Former Number(s): A87
Highway Authorities
Traditional Counties
Route outline (key)
This article is about the Class III road numbered C1232 maintained by Highland Council.
For other roads numbered C1232, see C1232.
The C1232 is, it its entirety, the former line of the A87 from Balmacara to Kyle of Lochalsh. The road was realigned along the south coast of Lochalsh, cutting a couple of miles of the distance. The old road remains, and is the signed route to Plockton from either end, via the C1221 which it meets roughly half way along.
Starting in Kyle, the road heads north at first along Main Street, and is one-way northbound, southbound traffic using Stoney Road (A U road). The two meet just across the railway bridge, and the C1221 continues north, along the sinuous Main Street, which drops towards the shore as it leaves Kyle behind. The railway is between road and sea as they follow the coast round to Erbusaig. Here, they diverge, with the C1221 continuing north to Plockton. The C1232 is now running east, through a wide, featureless glen. It is a mixture of narrow S2 and single track with passing places as it curves round into Balmacara. The first part of this scattered village that is reached is Balmacara Square, which has grown up around the old estate buildings, and then the road drops down to the A87 on the shore, the two running parallel as they converge in height.
Other nearby roads
A87 • A850 • A851 • A890 • C1221 (Highland) • C1222 (Highland) • T99 (Britain)
Class III Roads maintained by Highland Council
C1001 • C1002 • C1003 • C1004 • C1005 • C1006 • C1007 • C1008 • C1009 • C1010 • C1011 • C1012 • C1013 • C1014 • C1015 • C1016 • C1017 • C1018 • C1019 • C1020
C1241 • C1242 • C1243 • C1244 • C1245 • C1246 • C1247 • C1248 • C1249 • C1250
Retrieved from 'https://www.sabre-roads.org.uk/wiki/index.php?title=C1232_(Highland)&oldid=599345'
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Roads numbered C1232
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text:
Na fluidodinâmica, ondas de gravidade são ondas geradas em um meio fluido, ou na interface entre dois meios (por exemplo, entre a atmosfera e o oceano), que ocorrem devido entre à interação de duas forças: o princípio de Arquimedes (que tende a fazer com que matéria no meio flutue) e a gravidade (que puxa a matéria em direção à superfície).

Mecânica de fluidos
Efeitos da gravitação


Dockside is the leading service-provider to the U.S. power generation equipment market. We specialize in the packaging & preservation of power generation and power transmission & distribution equipment.
Our innovative packaging & preservation solutions have ensured perfect product delivery 100% of the time for our clients who control 71% of the global power generation equipment market.


text:
Deer Lakes football star Michael Sullivan signs on with Pitt
Through: Greg Macafe
Wednesday December 16, 2020 | 5:50 p.m.
Christophe Horner | Tribune-Review
Michael Sullivan of Deer Lakes celebrates after scoring the tying goal during the second half of the WPIAL Class AA Championship match against Shady SIde Academy on Thursday November 5, 2020, at North Allegheny.
His engagement was low-key, but on Wednesday, Deer Lakes senior football star Michael Sullivan announced his collegiate decision with a bang.
After leading the Lancers to their second state championship appearance in three years this season, the WPIAL Class 2A Player of the Year has said he will play for Pitt.
4 next # H2P ???????? pic.twitter.com/3g63Itxbei
– Michael Sullivan (@ Msullivan_09) December 16, 2020
"That's good. I mean, it's up to the WPIAL championship win for one of the best feelings I've ever had, for sure," Sullivan said.
"Being able to play at the college level in front of your hometown is something you dream of. Ever since I was little and could think of playing at the next level, Pitt has always been there to be able to play in front of my family, and being able to come to my games is going to be a very important part. Now that I'm able to do it, it's huge.
Sullivan has won back-to-back Valley News Dispatch Boys Football Player of the Year awards. He led the Lancers to their first WPIAL Class 2A Championship this season with a shootout victory over Shady Side Academy, ending his senior season with 22 goals and 11 assists.
He scored the tying goal in the WPIAL Championship game after the Lancers lost 1-0, and he has also faced doubles and trebles on several occasions this season.
Now Sullivan is heading for one of the best football programs in the country. Pitt has gone 7-1 this season and lost to Clemson, 2-1, in the ACC Championship game. The Panthers held the No. 1 ranking in the country before the loss.
Sullivan said he and Pitt's assistant coach Rich Constanzo started talking in February. Things picked up recently when he spoke to head coach Jay Vidovich.
"Hearing him talk about the game movie he watched from me before the call and picking out little details that I couldn't even make out after watching it four or five times," Sullivan said. "It's going to be absolutely great playing with someone with that kind of skill, so I can't wait."
Sullivan said he realizes playing in the ACC will be a big leap.
"The most important thing they pointed out to me is that I'm going to have to come and work for this," Sullivan said. "There are no fixed positions in a varsity environment because the coaching staff are trying to put food on their tables, and they're going to come up with the top 11 that they think can win the games, and that is just going to come down to what I do at camp and what I can do in the preseason and let the work speak for itself.
Greg Macafee is an editor for Tribune-Review. You can contact Greg by email at [email protected] or via Twitter .
Key words: Deer lakes
Navy Federal Partners with TrueCar as Carvana Seeks Record Growth
Three graphs show a K-shaped recovery


text:
'Global brand' stardust rubs off across Arla during 'strong' 2011
By Ben Bouckley
24-Feb-2012 - Last updated on 24-Feb-2012 at 12:28 GMT
Related tags: Brand, Value added
Arla Foods has announced a strong set of results for 2011, and the company has told DairyReporter.com that this is due in large part tighter 'global brand' focus that is boosting its entire portfolio.
The Danish-Swedish-German co-operative group reported a turnover of almost DKK 55bn (DKK 49bn: 2010) while profits also grew to DKK 1.311bn (DKK 1.268bn: 2010).
Welcoming "strong results in a difficult time", given the European debt crisis (with 80% of Arla's business based in Europe), CEO Peder Tuborgh admitted that greater consumer uptake of discount, rather than branded problems, had hurt Arla's earnings in this region.
"But at the same time, we're seeing a rising demand in markets outside Europe, which will offset the flattening growth in Europe," he added.
Tuborgh noted Arla's success in Middle East and North Africa (MENA) and Russia, where sales grew by 16% (DKK 4.1bn) and 27% (DKK 540m) respectively, as well as a "major breakthrough" towards becoming a major market player in Germany, following the firm's merger with Hansa-Milch and its Allgäuland-Käsereien acquisition.
Arla, Lurpak, Castello
Arla said that half its 2011 revenue growth was organic – the firm is targeting a DKK 75bn turnover by 2015 – and was in part driven by good growth for its three 'global brands': Arla (+8%, DKK 20.6m) Lurpak (13%) and Castello (+8%).
CFO Frederik Lotz said global brand growth ahead of the rest of the company was very positive, with sales driven by "strategically important products with high added value" and a focus on selected global markets.
Arla's global brand strategy was launched in October 2010, and involves focusing on its three global brands; the firm's 2015 group strategy involves targeting Russia, Poland (+19% sales growth) the US and China as 'special growth markets', but the firm suggested yesterday that 2011 performance in the latter two was more muted.
Endless number of brands...
Asked whether Arla had benefited from focusing its resources on fewer 'global brands', the spokesman said: "There's no doubt that this is a big advantage to us, and we've seen it work almost immediately.
"Before we had a global brand strategy we had an endless amount of brands in each market. We're working on – and we've also worked on this over the past two years – streamlining and finding synergies, to build up around these three global brands.
"We're making sure that the brands that did not have potential as a standalone brand, can either become a sub-brand to one of these three main brands, or possibly we just stop producing it. You have to focus your business to get the most profit out of it."
He added: "We had to change some of the products – packaging, quality, so forth. Moving a brand into another brand is a journey that requires product adjustments.
"That's taken a lot of work, but we're definitely seeing the benefits of that because of the value these brands have is translating to more of our products."
Related topics: Suppliers, Financial plays, Proteins, peptides, amino acids
Milk phospholipids in early childhood development
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. VDR (SOLAS V/20.1 & 20.3) .
19.1.2.3) be fitted with the system required in paragraph 2.4** not later than the dates specified in paragraphs 2.4.2 and 2.4.3.
Existing ships can continue to comply with the requirements of SOLAS V/74 for Signalling Lamps (Reg.11) Navigational Equipment (Reg.12) and carriage of nautical publications (Reg.20) if they do not comply FULLY with the new requirements of SOLAS V Reg.19. See the full text of these three Regulations below.
All ships of over 150 gross tonnage, when engaged on international voyages, shall have on board an efficient daylight signalling lamp which shall not be solely dependent upon the ship's main source of electrical power.
* Refer to resolution MSC.95(72), Performance Standards for daylight signalling lamps.
iii.) assembly of that ship has commenced comprising at least 50 tonnes or 1% of the estimated mass of all structural material whichever is less.
** See resolution A.156(ES.IV), Recommendation on the carriage of electronic position-fixing equipment, and resolution A.815(19), World-wide radionavigation system.
4.) means for taking bearings as nearly as practicable over an arc of the horizon of 360°.
ii.) Each magnetic compass referred to in subparagraph (i) shall be properly adjusted and its table or curve of residual deviations shall be available at all times.
iii.) A spare magnetic compass, interchangeable with the standard compass, shall be carried, unless the steering compass mentioned in subparagraph (i)(2) or a gyro-compass is fitted.
iv.) The Administration, if it considers it unreasonable or unnecessary to require a standard magnetic compass, may exempt individual ships or classes of ships from these requirements if the nature of the voyage, the ship's proximity to land or the type of ship does not warrant a standard compass, provided that a suitable steering compass is in all cases carried.
c.) Ships of less than 150 gross tonnage shall, as far as the Administration considers it reasonable and practicable, be fitted with a steering compass and have means for taking bearings.
ii.) on ships of 1,600 gross tonnage and upwards a gyro repeater or gyro repeaters shall be provided and shall be suitably placed for taking bearings as nearly as practicable over an arc of the horizon of 360°.
e.) Ships of 1,600 gross tonnage and upwards, constructed before 1 September 1984, when engaged on international voyages, shall be fitted with a gyro-compass complying with the requirements of paragraph (d).
f.) Ships with emergency steering positions shall at least be provided with a telephone or other means of communication for relaying heading information to such positions. In addition, ships of 500 gross tonnage and upwards constructed on or after 1 February 1992 shall be provided with arrangements for supplying visual compass readings to the emergency steering position.
g.) Ships of 500 gross tonnage and upwards constructed on or after 1 September 1984 and ships of 1,600 gross tonnage and upwards constructed before 1 September 1984 shall be fitted with a radar installation. From 1 February 1995, the radar installation shall be capable of operating in the 9 GHz frequency band. In addition, after 1 February 1995, passenger ships irrespective of size and cargo ships of 300 gross tonnage and upwards when engaged on international voyages shall be fitted with a radar installation capable of operating in the 9 GHz frequency band. Passenger ships of less than 500 gross tonnage and cargo ships of 300 gross tonnage and upwards but less than 500 gross tonnage may be exempted from compliance with the requirements of paragraph (r) at the discretion of the Administration, provided that the equipment is fully compatible with the radar transponder for search and rescue.
h.) Ships of 10,000 gross tonnage and upwards shall be fitted with two radar installations, each capable of being operated independently*** of the other. From 1 February 1995, at least one of the radar installations shall be capable of operating in the 9 GHz frequency band.
*** Refer to section 4 of the Recommendation on perfomance standards for radar equipment adopted by the Organization by resolution A.477(XII) and resolution MSC.64(67), Recommendations on new and amended performance standards (annex 4).
i.) Facilities for plotting radar readings shall be provided on the navigation bridge of ships required by paragraph (g) or (h) to be fitted with a radar installation. In ships of 1,600 gross tonnage and upwards constructed on or after 1 September 1984 the plotting facilities shall be at least as effective as a reflection plotter.
cc.) if of 15,000 gross tonnage and upwards, but less than 20,000 gross tonnage, by 1 September 1988.
# Refer to the Performance standards for automatic radar plotting aids adopted by the Organization by resolution A.823(19).
iii.) The Administration may exempt ships from the requirements of this paragraph, in cases where it considers it unreasonable or unnecessary for such equipment to be carried, or when the ships will be taken permanently out of service within two years of the appropriate implementation date.
k.) When engaged on international voyages ships of 1,600 gross tonnage and upwards constructed before 25 May 1980 and ships of 500 gross tonnage and upwards constructed on or after 25 May 1980 shall be fitted with an echo-sounding device.
l.) When engaged on international voyages ships of 500 gross tonnage and upwards constructed on or after 1 September 1984 shall be fitted with a device to indicate speed and distance. Ships required by paragraph (j) to be fitted with an automatic radar plotting aid shall be fitted with a device to indicate speed and distance through the water.
m.) Ships of 1,600 gross tonnage and upwards constructed before 1 September 1984 and all ships of 500 gross tonnage and upwards constructed on or after 1 September 1984 shall be fitted with indicators showing the rudder angle, the rate of revolution of each propeller and in addition, if fitted with variable pitch propellers or lateral thrust propellers, the pitch and operational mode of such propellers. All these indicators shall be readable from the conning position.
n.) Ships of 100,000 gross tonnage and upwards constructed on or after 1 September 1984 shall be fitted with a rate-of-turn indicator.
## Refer to the Recommendation on the use and testing of shipborne navigational equipment adopted by the Organization by resolution A.157(ES.IV).
p.) When engaged on international voyages, ships of 1,600 gross tonnage and upwards shall be fitted with a radio direction-finding apparatus. The Administration may exempt a ship from this requirement if it considers it unreasonable or unnecessary for such apparatus to be carried or if the ship is provided with other radionavigation equipment suitable for use throughout its intended voyages.
q.) Until 1 February 1999, ships of 1,600 gross tonnage and upwards constructed on or after 25 May 1980 and before 1 February 1995, when engaged on international voyages, shall be fitted with radio equipment for homing on the radiotelephone distress frequency.
r.) All equipment fitted in compliance with this regulation shall be of a type approved by the Administration. Equipment installed on board ships on or after 1 September 1984 shall conform to appropriate performance standards not inferior to those adopted by the Organization*. Equipment fitted prior to the adoption of related performance standards may be exempted from full compliance with those standards at the discretion of the Administration, having due regard to the recommended criteria which the Organization might adopt in connection with the standards concerned.
s.) A rigidly connected composite unit of a pushing vessel and associated pushed vessel, when designed as a dedicated and integrated tug and barge combination, shall be regarded as a single ship for the purpose of this regulation.
t.) If the application of the requirements of this regulation necessitates structural alterations to a ship constructed before 1 September 1984, the Administration may allow extension of the time limit for fitting the required equipment not later than 1 September 1989, taking into account the first scheduled dry-docking of such a ship required by the present regulations.
u.) Except as provided elsewhere in this regulation, the Administration may grant to individual ships exemptions of a partial or conditional nature, when any such ship is engaged on a voyage where the maximum distance of the ship from the shore, the length and nature of the voyage, the absence of general navigation hazards, and other conditions affecting safety are such as to render the full application of this regulation unreasonable or unnecessary. When deciding whether or not to grant exemptions to an individual ship, the Administration shall have regard to the effect that an exemption may have upon the safety of all other ships.
General requirements for electromagnetic compatibility for all electrical and electronic ship's equipment (resolution A.813(19)).
Recommendation on performance standards for daylight signalling lamps (resolution MSC.95(72)).
Recommendation on methods of measuring noise levels at listening posts (resolution A.343(IX)).
Regarding unification of ARPA signals, see MSC/Circ.563 and IEC Publication 872.
All ships shall carry adequate and up-to-date charts,# sailing directions, lists of lights, notices to mariners, tide tables and all other nautical publications necessary for the intended voyage.
# Refer to the Recommendation on performance standards for electronic chart display and information systems (ECDIS) (resolution A.817(19), as amended) and resolution MSC.86(70).


All businesses large and small must have a vibrant online presence these days, including social media and content marketing. But your business can benefit as well from a variety of offline marketing efforts—tactics and maneuvers that don't cost a lot of money, but help keep brand awareness high within your business community.
1. Scatter your business cards far and wide. Even in our digital era, printed business cards are useful for keeping your business top-of-mind. The trick is distributing them with greater frequency and in locations that might not appear at first blush as promising venues.
Planning to dine out at a prestigious local restaurant this week? Leave a business card along with your tip. Ask your employees to pin a business card up on bulletin boards located in the various businesses they frequent. Be sure to generously distribute them at any tradeshows you attend.
2. Get actively involved in tradeshows and associations. Business still thrives on relationships. Whether you're promoting a product or simply attending, tradeshows are a great place to forge new partnerships, attract prospective customers and just generally get more people aware of your brand.
Many trade associations distribute publications offering industry updates and insights. Contact the editors of these publications and see if they're looking for short, insightful articles about new trends and activities (most are). Then try your hand at writing an article, submitting it and (if it's accepted) politely insist on including your byline and title.
3. Build a reputation as an industry thought leader. With a few publications and/or speaking engagements under your belt, you're well on the way to becoming a thought leader in your particular industry. Granted, as a CEO or business owner, you don't have a lot of free time—but landing one or two speaking gigs at a high-profile industry event is worth its weight in marketing gold.
4. Explore giving your product away for free. It's not a business practice that should be adopted on a daily basis, but anytime you find an opportunity to offer your product as a top prize in a community contest—or donate your services for a worthy cause—you're generating goodwill within the community and increasing awareness of your brand.
Additionally, look into cross-promotional opportunities with businesses that complement your own. It's another way of getting prospective customers to think about your business differently, and to establish a presence in an unexpected way.
5. Leverage your expertise to appear on local media. Local and regional media—print, TV, radio, electronic—needs a constant infusion of new stories. As you build your reputation, reach out to local columnists, news anchors and others you admire, offering your expertise to give a local slant to national or international business news.
Building such a relationship doesn't happen overnight; it requires persistence and an ability to frame yourself as a credible and persuasive source. The good news is—once you're in, requests for appearances will likely multiply, expanding the range of awareness of both you and your company.
6. Track your company's events in photographs and video. Images remain a very powerful marketing tool. So while guest speaking engagements, community activities and other events happen offline (that is, in real life), sharing photos and videos of them are often wildly popular on social media. "Real-life photos [and video] from the offline world show the personality of your company and increase online user engagement," notes marketing strategist Jayson DeMers.
Given the right amount of effort and persistence, offline activities can spur greater momentum for your overall marketing strategies.


Subject: Dinosaur Island or Clans of Caledonia?
I'm posting on COC page also, I'm hoping some fellow gamers have both games.
I play board games with the family normally 3-4 players & I have to Pretty much know the game rules before we play our first learning game.
My wife & children like fun games like Ticket to ride, Alien frontiers and Clank and so on but I want to get them in to a few deeper games so which would be suited best which is better to teach with easier learning curve? We live in a Ireland UK and visited Scotland many times so the theme of Clans is great but we also like all the Jurasic park films. Thank you in advance for any advise. I would love both games but I would never get them both to the table.
You're going to have a much more fun time with Dinosaur Island if the burden of knowing and explaining the rules rests on you. Clans of Caledonia is like Terra Mystica lite, whereas Dinosaur Island is just a light worker placement game to begin with.
Thank you Steve this is exactly what I needed to hear, I have Terra Mystica and I have played it & love it but my children will not be ready for it for another year or so.
I'm a bit late to the thread but my 11 year old son and I played our first game last night...it was amazing! Not only did he have a great time playing, he also ended up pulling ahead in the last round to win after trailing significantly throughout the game. The game is somewhat complex for us but the theme is so immersive that it helps the mechanics make sense, leading to a great gaming experience. The other part that helps is the breaking up of the turn into the 4 easily digested phases. It looks crazy spread out on the table so we were a little scared to try it out but we are also fans of the movies and couldn't resist. And on that note I will now admit to having never played Clans of Caledonia, I just needed to vent my excitement about our first game! Good luck with your decision.
Hi Collin I ordered Dinosaur Island this evening! Thank you for such a informative reply & sounds like you had great game! You have me stoked for playing with my family! Thank you.
That's great! I hope you love it, we played a second game this week and really enjoyed it. Good luck!


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New street names are decided under delegated powers by the Strategic Director of Places and Organisational Capacity in conjunction with the Cabinet Member for Environment. Numbering and naming of properties is decided by the Address Management team in accordance with BS7666 national addressing standards and best practice.
A decision is issued to the applicant and notifications are sent to Royal Mail, Ordnance Survey, emergency services, utility companies and other Council departments.
Approved changes are added to the Local Land and Property Gazetteer and Street Gazetteer.
Changes are submitted regularly to the National Land and Property Gazetteer (NLPG).


text:
HomeExposing The Illegal Organ Trade
Exposing The Illegal Organ Trade
Exposing The Illegal Organ Trade is a TV show on Australian national television from ABC with an average rating of 4.0 stars by TVCatchUpAustralia.com's visitors. We have 1 episodes of Exposing The Illegal Organ Trade in our archive. The first episode of Exposing The Illegal Organ Trade was broadcast in November, 2021. Did you miss an episode of Exposing The Illegal Organ Trade but don't you wan't that to happen in the future? Please set an alarm and add Exposing The Illegal Organ Trade to your favourites, so we can remind you by email when there's a new episode available to watch. Completely free: handy!
A shocking investigation into one of the world's most brutal trades - the illegal buying and selling of human organs.


This book is a gathering of important issues relating to planning local economic development. It presents many interesting cases and examples that are helpful for students.
A comprehensive book that covers most of the local economic development planning issues. It explains the topics with cases and examples that make easy for students to understand.
This book is a great companion for any course on local economic development covering the theories, concepts and challenges with a plethora of case studies. An essential text for students considering issues related to local economic development.
Very good book with complete problem of LER.
This is one of the most comprehensive local economic development textbooks for a graduate planning class out there. I really like the addition of the teaching cases.
This text provides a comprehensive exploration of the theories and challenges of local economic development. This updated edition, successfully incorporates the challenge of sustainable living in the 21st century, with new case studies and illustrations relevant to the current context. An essential text for any development planning course.


text:
Occurrence of distinct PML-RAR-α fusion gene isoforms in patients with acute promyelocytic leukemia detected by reverse transcriptase/polymerase chain reaction
Sai Juan Chen, Zhu Chen, Alex Chen, Jian Hua Tong, Shuo Dong, Zhen Yi Wang, Samuel Waxman, Arthur Z Zelent
A specific 'nested' reverse transcriptase/polymerase chain reaction (RT/PCR) procedure was used to characterize the expression patterns of PML-RAR-α chimeric mRNAs in 32 patients with acute promyelocytic leukemia (APL). The sensitivity of the technique was such that the fusion gene transcript could be detected from as little as 2.5 pg of total leukemic cell RNA against a background of 1 μg of cellular RNA lacking the PML-RAR-α fusion gene transcript(s). In 19 cases the PML-RAR-α isoform referred to here as long was identified. A short isoform, which in comparison with the long form lacks three PML exons, was detected in 11 other cases. A third PML-RAR-α mRNA isoform, in which the most 3′ PML exon present in the long-type isoform was truncated in its sequences lying immediately upstream of RAR-α B region, was found and characterized in a single patient. In one APL patient with a variant translocation t(11;17), the PCR product corresponding to PML-RAR-α chimeric mRNAs could not be amplified despite the presence of RAR-α gene rearrangement. Genomic and PCR analysis showed that the different PML-RAR-α isoforms found in APL patients arise as a result of distinct translocation breakpoints. In each case the exons encoding the B-F regions of RAR-α are expressed and are spliced downstream from variable PML gene exons. The 'nested' RT/PCR analysis of the PML-RAR-α fusion gene proved to be a rapid and sensitive tool for the diagnosis of the APL and for monitoring the residual APL chimeric mRNA expression during complete remission.
Acute Promyelocytic Leukemia
Gene Fusion
RNA Isoforms
Gene Rearrangement
Chen, S. J., Chen, Z., Chen, A., Tong, J. H., Dong, S., Wang, Z. Y., ... Zelent, A. Z. (1992). Occurrence of distinct PML-RAR-α fusion gene isoforms in patients with acute promyelocytic leukemia detected by reverse transcriptase/polymerase chain reaction. Oncogene, 7(6), 1223-1232.
Occurrence of distinct PML-RAR-α fusion gene isoforms in patients with acute promyelocytic leukemia detected by reverse transcriptase/polymerase chain reaction. / Chen, Sai Juan; Chen, Zhu; Chen, Alex; Tong, Jian Hua; Dong, Shuo; Wang, Zhen Yi; Waxman, Samuel; Zelent, Arthur Z.
In: Oncogene, Vol. 7, No. 6, 06.1992, p. 1223-1232.
Chen, SJ, Chen, Z, Chen, A, Tong, JH, Dong, S, Wang, ZY, Waxman, S & Zelent, AZ 1992, 'Occurrence of distinct PML-RAR-α fusion gene isoforms in patients with acute promyelocytic leukemia detected by reverse transcriptase/polymerase chain reaction', Oncogene, vol. 7, no. 6, pp. 1223-1232.
Chen SJ, Chen Z, Chen A, Tong JH, Dong S, Wang ZY et al. Occurrence of distinct PML-RAR-α fusion gene isoforms in patients with acute promyelocytic leukemia detected by reverse transcriptase/polymerase chain reaction. Oncogene. 1992 Jun;7(6):1223-1232.
Chen, Sai Juan ; Chen, Zhu ; Chen, Alex ; Tong, Jian Hua ; Dong, Shuo ; Wang, Zhen Yi ; Waxman, Samuel ; Zelent, Arthur Z. / Occurrence of distinct PML-RAR-α fusion gene isoforms in patients with acute promyelocytic leukemia detected by reverse transcriptase/polymerase chain reaction. In: Oncogene. 1992 ; Vol. 7, No. 6. pp. 1223-1232.
@article{3811b801629845ab94c53504bd11853e,
title = "Occurrence of distinct PML-RAR-α fusion gene isoforms in patients with acute promyelocytic leukemia detected by reverse transcriptase/polymerase chain reaction",
abstract = "A specific 'nested' reverse transcriptase/polymerase chain reaction (RT/PCR) procedure was used to characterize the expression patterns of PML-RAR-α chimeric mRNAs in 32 patients with acute promyelocytic leukemia (APL). The sensitivity of the technique was such that the fusion gene transcript could be detected from as little as 2.5 pg of total leukemic cell RNA against a background of 1 μg of cellular RNA lacking the PML-RAR-α fusion gene transcript(s). In 19 cases the PML-RAR-α isoform referred to here as long was identified. A short isoform, which in comparison with the long form lacks three PML exons, was detected in 11 other cases. A third PML-RAR-α mRNA isoform, in which the most 3′ PML exon present in the long-type isoform was truncated in its sequences lying immediately upstream of RAR-α B region, was found and characterized in a single patient. In one APL patient with a variant translocation t(11;17), the PCR product corresponding to PML-RAR-α chimeric mRNAs could not be amplified despite the presence of RAR-α gene rearrangement. Genomic and PCR analysis showed that the different PML-RAR-α isoforms found in APL patients arise as a result of distinct translocation breakpoints. In each case the exons encoding the B-F regions of RAR-α are expressed and are spliced downstream from variable PML gene exons. The 'nested' RT/PCR analysis of the PML-RAR-α fusion gene proved to be a rapid and sensitive tool for the diagnosis of the APL and for monitoring the residual APL chimeric mRNA expression during complete remission.",
author = "Chen, {Sai Juan} and Zhu Chen and Alex Chen and Tong, {Jian Hua} and Shuo Dong and Wang, {Zhen Yi} and Samuel Waxman and Zelent, {Arthur Z}",
T1 - Occurrence of distinct PML-RAR-α fusion gene isoforms in patients with acute promyelocytic leukemia detected by reverse transcriptase/polymerase chain reaction
AU - Chen, Sai Juan
AU - Chen, Zhu
AU - Chen, Alex
AU - Tong, Jian Hua
AU - Dong, Shuo
AU - Wang, Zhen Yi
AU - Waxman, Samuel
AU - Zelent, Arthur Z
N2 - A specific 'nested' reverse transcriptase/polymerase chain reaction (RT/PCR) procedure was used to characterize the expression patterns of PML-RAR-α chimeric mRNAs in 32 patients with acute promyelocytic leukemia (APL). The sensitivity of the technique was such that the fusion gene transcript could be detected from as little as 2.5 pg of total leukemic cell RNA against a background of 1 μg of cellular RNA lacking the PML-RAR-α fusion gene transcript(s). In 19 cases the PML-RAR-α isoform referred to here as long was identified. A short isoform, which in comparison with the long form lacks three PML exons, was detected in 11 other cases. A third PML-RAR-α mRNA isoform, in which the most 3′ PML exon present in the long-type isoform was truncated in its sequences lying immediately upstream of RAR-α B region, was found and characterized in a single patient. In one APL patient with a variant translocation t(11;17), the PCR product corresponding to PML-RAR-α chimeric mRNAs could not be amplified despite the presence of RAR-α gene rearrangement. Genomic and PCR analysis showed that the different PML-RAR-α isoforms found in APL patients arise as a result of distinct translocation breakpoints. In each case the exons encoding the B-F regions of RAR-α are expressed and are spliced downstream from variable PML gene exons. The 'nested' RT/PCR analysis of the PML-RAR-α fusion gene proved to be a rapid and sensitive tool for the diagnosis of the APL and for monitoring the residual APL chimeric mRNA expression during complete remission.
AB - A specific 'nested' reverse transcriptase/polymerase chain reaction (RT/PCR) procedure was used to characterize the expression patterns of PML-RAR-α chimeric mRNAs in 32 patients with acute promyelocytic leukemia (APL). The sensitivity of the technique was such that the fusion gene transcript could be detected from as little as 2.5 pg of total leukemic cell RNA against a background of 1 μg of cellular RNA lacking the PML-RAR-α fusion gene transcript(s). In 19 cases the PML-RAR-α isoform referred to here as long was identified. A short isoform, which in comparison with the long form lacks three PML exons, was detected in 11 other cases. A third PML-RAR-α mRNA isoform, in which the most 3′ PML exon present in the long-type isoform was truncated in its sequences lying immediately upstream of RAR-α B region, was found and characterized in a single patient. In one APL patient with a variant translocation t(11;17), the PCR product corresponding to PML-RAR-α chimeric mRNAs could not be amplified despite the presence of RAR-α gene rearrangement. Genomic and PCR analysis showed that the different PML-RAR-α isoforms found in APL patients arise as a result of distinct translocation breakpoints. In each case the exons encoding the B-F regions of RAR-α are expressed and are spliced downstream from variable PML gene exons. The 'nested' RT/PCR analysis of the PML-RAR-α fusion gene proved to be a rapid and sensitive tool for the diagnosis of the APL and for monitoring the residual APL chimeric mRNA expression during complete remission.


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