text:
Bone Marrow Cells
Bone and Bones
Embryonic Stem Cells
T-Lymphocytes
Adult Stem Cells
Antilymphocyte Serum
Neural Stem Cells
Multipotent Stem Cells
Fetal Blood
Granulocytes
Stromal Cells
B-Lymphocytes
Transplantation Chimera
Radiation Chimera
Cytomegalovirus
Mice, Inbred BALB C
Herpesvirus 6, Human
BK Virus
Mice, Inbred C3H
Mice, SCID
Diseases 49
Graft vs Host Disease
Anemia, Aplastic
Hematologic Neoplasms
Cytomegalovirus Infections
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Hepatic Veno-Occlusive Disease
Leukemia, Myeloid, Acute
Bone Marrow Diseases
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Opportunistic Infections
Acute Disease
Lymphoma, Non-Hodgkin
Leukemia, Myeloid
Bone Marrow Neoplasms
Severe Combined Immunodeficiency
Lymphoproliferative Disorders
Hodgkin Disease
Pancytopenia
Roseolovirus Infections
Bone Resorption
Blood Group Incompatibility
beta-Thalassemia
Pneumonia, Viral
Liver Failure
Polyomavirus Infections
Immunologic Deficiency Syndromes
Neoplasm, Residual
Bone Neoplasms
Bronchiolitis Obliterans
Epstein-Barr Virus Infections
Immunosuppressive Agents
HLA Antigens
Granulocyte Colony-Stimulating Factor
Carmustine
Antiviral Agents
Antibodies, Monoclonal
Myeloablative Agonists
Antifungal Agents
Antigens, CD
Antineoplastic Agents
Cyclosporins
Minor Histocompatibility Antigens
Vidarabine
Transplantation, Homologous
Transplantation, Autologous
Transplantation Conditioning
Whole-Body Irradiation
Histocompatibility Testing
Bone Marrow Purging
Transplantation, Isogeneic
Peripheral Blood Stem Cell Transplantation
Lymphocyte Depletion
Leukocyte Transfusion
Bone Marrow Examination
Hematopoietic Stem Cell Mobilization
Antineoplastic Combined Chemotherapy Protocols
Mesenchymal Stem Cell Transplantation
Fatal Outcome
Colony-Forming Units Assay
Cord Blood Stem Cell Transplantation
Disease-Free Survival
Lymphocyte Transfusion
Cell Transplantation
Actuarial Analysis
Cell Separation
Leukocyte Count
Fetal Tissue Transplantation
Islets of Langerhans Transplantation
Skin Transplantation
Transplantation, Heterotopic
Heart-Lung Transplantation
Blood Cell Count
Platelet Count
Platelet Transfusion
Psychiatry and Psychology 2
Graft Survival
Histocompatibility
Graft Rejection
Immunocompromised Host
Transplantation Immunology
Bone Remodeling
Graft vs Host Reaction
Graft vs Leukemia Effect
Chimerism
Stem Cell Niche
Cell Lineage
Graft vs Tumor Effect
Transplantation Tolerance
Virus Activation
Anthropology, Education, Sociology and Social Phenomena 2
Named Groups 3
Tissue Donors
Living Donors
Health Care 16
Tissue and Organ Procurement
Dentist's Practice Patterns
Age Factors
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesNamed Groups
Bone Marrow TransplantationTransplantation, HomologousBone MarrowHematopoietic Stem Cell TransplantationBone Marrow CellsTransplantation, AutologousGraft vs Host DiseaseStem CellsStem Cell TransplantationTransplantation ConditioningWhole-Body IrradiationTissue DonorsHematopoietic Stem CellsGraft SurvivalKidney TransplantationAnemia, AplasticLeukemiaBone and BonesHistocompatibility TestingHematologic NeoplasmsTransplantation ChimeraHistocompatibilityBusulfanImmunosuppressive AgentsTransplantation
autologous
There are transplanted both autologous and allogeneic (with stem cells of brothers/sisters or unrelated donors) transplants. (bookinghealth.com)
Gas and supply okc 13 The analysis of the survey data spanning over 20 years has shown a continued and constant increase in the annual numbers of HSCT and transplant rates (number of HSCT per 10 million inhabitants) for both allogeneic and autologous HSCT. (gaselectricity.in)
Multiple transplants may include multiple transplants defined as subsequent transplants within a planned double or triple autologous or allogeneic transplant protocol, and retransplants (autologous or allogeneic) defined as unplanned HSCT for rejection or relapse after a previous HSCT. (gaselectricity.in)
In autologous transplants, patients receive their own stem cells. (pallipedia.org)
Mechanism of tolerance following class II gene transduction of autologous swine bone marrow. (ac.ir)
There are three known accessible sources of autologous adult stem cells in humans: Bone marrow, which requires extraction by harvesting, that is, drilling into bone (typically the femur or iliac crest). (wikipedia.org)
Of all stem cell types, autologous harvesting involves the least risk. (wikipedia.org)
By definition, autologous cells are obtained from one's own body, just as one may bank his or her own blood for elective surgical procedures. (wikipedia.org)
Embryonic cell lines and autologous embryonic stem cells generated through somatic cell nuclear transfer or dedifferentiation have also been proposed as promising candidates for future therapies. (wikipedia.org)
Stem-cell therapy for treatment of myocardial infarction usually makes use of autologous bone-marrow stem cells (a specific type or all), however other types of adult stem cells may be used, such as adipose-derived stem cells. (wikipedia.org)
The 4 major units that perform Allogeneic - stem cells harvested from genetically similar but not identical donors - and Autologous - stem cells harvested from self- HCTs are found at the "EVANGELISMOS" Hospital in Athens, the "PAPANIKOLAOU" Hospital in Thessaloniki and the PATRAS UNIVERSITY GENERAL HOSPITAL in Rio-Patras and the "AGHIA SOPHIA" Children's Hospital in Athens. (wikipedia.org)
Allogeneic
Electricity prices going up In addition to transplant rates and indications, this report focuses on the use of donors other than HLA identical siblings and matched unrelated donors for allogeneic HSCT. (gaselectricity.in)
In some types of leukemia, the graft-versus-tumor effect that occurs after allogeneic bone marrow transplantation and peripheral blood stem cell transplantation is crucial to the effectiveness of the treatment - when white blood cells from the donor (the graft) identify the cancer cells that remain in the patient's body after the chemotherapy and/or radiation therapy (the tumor) as foreign and attack them. (pallipedia.org)
At the Bone Marrow Transplantation Unit of the University Hospital of Patras, a fully accredited Allogeneic Hematopoietic Stem Cell Transplantation Program has been established, which performs all types of transplants (related, unrelated, haploidentical). (wikipedia.org)
In allogeneic cell therapy the donor is a different person to the recipient of the cells. (wikipedia.org)
Hematopoietic Cell Transplantation
In Greece, Hematopoietic Cell Transplantation (HCT) was first performed in 1985 and over 250 are now carried out every year. (wikipedia.org)
Results from the study suggest that PLX-R18 is safe and may significantly improve outcomes after bone marrow failure or hematopoietic cell transplantation. (wikipedia.org)
donor bone marrow
Donor bone marrow infusions are tolerogenic in human renal transplantation. (ac.ir)
Donor-specific transfusion and donor bone marrow infusion in renal transplantation tolerance: a review of efficacy and mechanisms. (ac.ir)
Total body irradiation in the setting of bone marrow transplantation serves to destroy or suppress the recipient's immune system, preventing immunologic rejection of transplanted donor bone marrow or blood stem cells. (wikipedia.org)
The Department of Hematology, Oncology, Hemostaseology , Rheumatology and Infectiology is a big center for bone marrow and stem cell transplants. (bookinghealth.com)
He is an editor, co-editor and/or reviewer of many scientific journals in hematology, oncology, immunology, transplantation and internal medicine. (wikipedia.org)
Stem cells can also be taken from umbilical cord blood just after birth. (wikipedia.org)
Bone marrow transplant is the most widely used stem-cell therapy, but some therapies derived from umbilical cord blood are also in use. (wikipedia.org)
Additionally, efforts to market treatments based on transplant of stored umbilical cord blood have been controversial. (wikipedia.org)
The FDA has approved five hematopoietic stem-cell products derived from umbilical cord blood, for the treatment of blood and immunological diseases. (wikipedia.org)
On October 27, 2014, it was reported that Case Western Reserve University will conduct a preclinical study of PLX-R18 cells in umbilical cord blood transplants for the treatment of blood cancers and genetic diseases. (wikipedia.org)
World Marrow Donor Association
On 1st January 2017 BMDW merged with NetCord and has become a service of the World Marrow Donor Association (WMDA). (wikipedia.org)
To do and perform all other acts and things which in the broadest sense relate or may be conducive to the foresaid purpose NetCord World Marrow Donor Association (WMDA) data of organisations Search & Match tool BMDW Annual Report Statistics 2015 2016 - Powley L, et al. (wikipedia.org)
embryonic stem
In mammals, there are two broad types of stem cells: embryonic stem cells, which are isolated from the inner cell mass of blastocysts, and adult stem cells, which are found in various tissues. (wikipedia.org)
Stem-cell therapy has become controversial following developments such as the ability of scientists to isolate and culture embryonic stem cells, to create stem cells using somatic cell nuclear transfer and their use of techniques to create induced pluripotent stem cells. (wikipedia.org)
Research into human embryonic stem cells is controversial, and regulation varies from country to country, with some countries banning it outright. (wikipedia.org)
Isolation and infusion of donor CD34+ bone marrow cells in cadaver kidney transplantation. (ac.ir)
Stony Brook is home to Long Island's first kidney transplantation program which has performed over 1,000 transplants, and initiated the nation's first Pediatric Multiple Sclerosis Center. (wikipedia.org)
Gas mask bong nfl Unrelated donor transplants include HSCT from unrelated donors with peripheral blood and marrow as a stem cell source but not cord blood HSCT, these are shown as cord blood HSCT in Figure 3a. (gaselectricity.in)
It is an allogenic stem therapy based on mesenchymal stem cells (MSCs) derived from the bone marrow of adult donors. (wikipedia.org)
Bone Marrow Donors Worldwide (BMDW) is an organization based in Leiden, Netherlands, that coordinates the collection of the HLA phenotypes and other relevant data of volunteer hematopoietic cell donors (used to perform what used to be called bone marrow transplants, but now referred as hematopoietic cell transplants) and cord blood units across the globe. (wikipedia.org)
Joining BMDW database requires a registry to be fully operational, and must have at least 50 HLA-typed unrelated stem cell donors or cord blood units. (wikipedia.org)
To facilitate the exchange of information and improve business relations, the WMDA provides access to contact data of organisations that are listing donors or cord blood products in the global database of Bone Marrow Donors Worldwide. (wikipedia.org)
The BMDW is the world's largest hematopoietic cell database, listing more than 29.5 million stem cell donors and over 721,289 cord blood units. (wikipedia.org)
These global hematopoietic cells from donors or cord blood units are used to transplant patients around the world with a variety of with life-threatening blood disorders such as leukemia, lymphoma, aplastic anemia, as well as certain immune system and metabolic disorders. (wikipedia.org)
BMDW's mission is to create a comprehensive, fair, and equitable global list of unrelated stem cell donors and cord blood products that shall allow fast determination of whether a matched donor is available for a patient in need of a hematopoietic stem cell transplant. (wikipedia.org)
The purpose of BMDW still remains the same, to collect the HLA phenotypes of volunteer stem cell donors and cord blood units and to co-ordinate their worldwide distribution. (wikipedia.org)
Bone marrow transplantation and peripheral blood stem cell transplantation are procedures that restore stem cells that have been destroyed by high doses of chemotherapy and/or radiation therapy. (pallipedia.org)
Bone marrow transplantation and peripheral blood stem cell transplantation are used in cancer treatment is to make it possible for patients to receive very high doses of chemotherapy and/or radiation therapy - treatments that can severely damage or destroy the patient's bone marrow. (pallipedia.org)
During chemotherapy, most growing cells are killed by the cytotoxic agents. (wikipedia.org)
A fact sheet that explains the step-by-step procedures of two types of transplantations used with high-dose chemotherapy. (dmoztools.net)
A not-for-profit organization that provides publications and support services to bone marrow, peripheral blood stem cell, and cord blood transplant patients and survivors. (dmoztools.net)
Provides access to US transplant resources, donor information, cord blood information and research data. (dmoztools.net)
The BMDW Editorial Board consists of one representative of each stem cell donor registry or cord blood bank participating in BMDW, and meets twice a year to discuss achievements and necessary improvements. (wikipedia.org)
BMDW participants consist of 75 hematopoietic cell donor registries from 53 countries, and 53 cord blood banks from 36 countries. (wikipedia.org)
Search & Match tool: The BMDW provides a fast preliminary search tool to find the best matched stem cell donor or cord blood unit for a patient in need of a transplant. (wikipedia.org)
The tool is primarily intended for use by professionals in the field of stem cell transplantation with profound knowledge of HLA, such as search coordinators and transplant physicians from transplant centres, stem cell donor registries, and cord blood banks. (wikipedia.org)
There is a great lack of treatment, although cord blood and hematopoietic stem cell transplantation (bone marrow transplant) seem to help in certain types while further research is being done. (wikipedia.org)
EBMT
Origin electricity faults 1, 2, 3, 4 The annual activity survey of the European Society of Blood and Marrow Transplantation (EBMT), describing the status of HSCT in Europe and affiliated countries, has become an instrument used to observe trends and to monitor changes in technology use. (gaselectricity.in)
Provides both EBMT members and other physicians involved in bone marrow transplant with information on related meetings, registries and data management, transplant guidelines, accreditation and corporate sponsorship. (dmoztools.net)
Natural gas in spanish More recently, the survey has included additional information on novel cell therapies with hematopoietic stem cells for non-hematopoietic use, as well as on the use of non-hematopoietic stem and progenitor cells. (gaselectricity.in)
5. Siemionow M, Nasir S. Chimerism and bone marrow based therapies in transplantation. (ac.ir)
Adult stem cells are frequently used in various medical therapies (e.g., bone marrow transplantation). (wikipedia.org)
The paracrine soluble factors produced by stem cells, known as the stem cell secretome, has been found to be the predominant mechanism by which stem cell-based therapies mediate their effects in degenerative, auto-immune and inflammatory diseases. (wikipedia.org)
Another stem-cell therapy called Prochymal, was conditionally approved in Canada in 2012 for the management of acute graft-vs-host disease in children who are unresponsive to steroids. (wikipedia.org)
PLX-R18 were initially developed with Prof Raphael Gorodetsky at Hadassah Hospital for the treatment of acute radiation syndrome and enhancement of bone marrow regeneration. (wikipedia.org)
The U.S. National Institutes of Health is currently evaluating Pluristem's PLX-R18 cells as a treatment for acute radiation syndrome. (wikipedia.org)
However, the dosing is still high enough that the ultimate result is the destruction of both the patient's bone marrow (allowing donor marrow to engraft) and any residual cancer cells. (wikipedia.org)
Two months thereafter, with the patient's condition deteriorating rapidly, the Director of Bone Marrow Transplantation, Cell Therapy and Transplantation Research Center at Hadassah felt that all available options had been exhausted and turned to Pluristem's PLX cells. (wikipedia.org)
allogenic
The girl had undergone two allogenic stem cell transplants since being admitted in August 2011, both of which failed to improve her condition. (wikipedia.org)
progenitor cells
In adult organisms, stem cells and progenitor cells act as a repair system for the body, replenishing adult tissues. (wikipedia.org)
In the strictest sense, this requires stem cells to be either totipotent or pluripotent-to be able to give rise to any mature cell type, although multipotent or unipotent progenitor cells are sometimes referred to as stem cells. (wikipedia.org)
Unipotent cells can produce only one cell type, their own, but have the property of self-renewal, which distinguishes them from non-stem cells (e.g. progenitor cells, which cannot self-renew). (wikipedia.org)
Healthy adult brains contain neural stem cells which divide to maintain general stem-cell numbers, or become progenitor cells. (wikipedia.org)
In healthy adult laboratory animals, progenitor cells migrate within the brain and function primarily to maintain neuron populations for olfaction (the sense of smell). (wikipedia.org)
Stem cells are undifferentiated biological cells that can differentiate into specialized cells and can divide (through mitosis) to produce more stem cells. (wikipedia.org)
In a developing embryo, stem cells can differentiate into all the specialized cells-ectoderm, endoderm and mesoderm (see induced pluripotent stem cells)-but also maintain the normal turnover of regenerative organs, such as blood, skin, or intestinal tissues. (wikipedia.org)
Potency: the capacity to differentiate into specialized cell types. (wikipedia.org)
Potency specifies the differentiation potential (the potential to differentiate into different cell types) of the stem cell. (wikipedia.org)
Totipotent (a.k.a. omnipotent) stem cells can differentiate into embryonic and extraembryonic cell types. (wikipedia.org)
Pluripotent stem cells are the descendants of totipotent cells and can differentiate into nearly all cells, i.e. cells derived from any of the three germ layers. (wikipedia.org)
Multipotent stem cells can differentiate into a number of cell types, but only those of a closely related family of cells. (wikipedia.org)
Oligopotent stem cells can differentiate into only a few cell types, such as lymphoid or myeloid stem cells. (wikipedia.org)
Properties of stem cells can be illustrated in vitro, using methods such as clonogenic assays, in which single cells are assessed for their ability to differentiate and self-renew. (wikipedia.org)
citation needed] Possible mechanisms of recovery include: Generation of heart muscle cells Stimulation of growth of new blood vessels to repopulate damaged heart tissue Secretion of growth factors Assistance via some other mechanism It may be possible to have adult bone-marrow cells differentiate into heart muscle cells. (wikipedia.org)
In this paradigm multipotent or unipotent cells differentiate into a specific cell type in the lab or after reaching the site of injury (via local or systemic administration). (wikipedia.org)
This was in addition to renal transplantation from an unrelated donor. (ac.ir)
The control group comprised eight patients who received renal transplantation from non-relative recipients. (ac.ir)
Pluristem was founded in 2001 by Shai Meretzki of the Technion, who made use of a stem cell patent which was developed during his Ph.D studies at The Rappaport Faculty Of Medicine, Technion, under the supervision of Dr. Shosh Merchav, together with Professors Dov Zipori and Avinoam Kadouri from the Weizmann Institute of Science. (wikipedia.org)
The USFDA has conferred orphan drug status on Pluristem's PLX cells for the treatment of Buerger's disease (2011) and aplastic anemia (2013). (wikipedia.org)
He is known for research in leukemia and other bone marrow disorders (such as aplastic anemia). (wikipedia.org)
doses
MSCs are purified from the marrow, cultured and packaged, with up to 10,000 doses derived from a single donor. (wikipedia.org)
Additionally, high doses of total body irradiation can eradicate residual cancer cells in the transplant recipient, increasing the likelihood that the transplant will be successful. (wikipedia.org)
Doses of total body irradiation used in bone marrow transplantation typically range from 10 to >12 Gy. (wikipedia.org)
Early research in bone marrow transplantation by E. Donnall Thomas and colleagues demonstrated that this process of splitting TBI into multiple smaller doses resulted in lower toxicity and better outcomes than delivering a single, large dose. (wikipedia.org)
Non-myeloablative bone marrow transplantation uses lower doses of total body irradiation, typically about 2 Gy, which do not destroy the host bone marrow but do suppress the host immune system sufficiently to promote donor engraftment. (wikipedia.org)
No sign of transplant rejection was observed in the presence of chimerism. (ac.ir)
Microchimerism and rejection in clinical transplantation. (ac.ir)
Information provided about the pediatric program includes the stem cell collection, conditions treated, and treatment areas. (dmoztools.net)
The hospital is also the regional referral center for trauma, perinatal and neonatal intensive care, burns, bone marrow and stem cell transplantation, cystic fibrosis, pediatric and adult AIDS, and is the regional resource center for emergency management. (wikipedia.org)
His activities include development and execution of clinical trials in blood and bone marrow cancers, transplantation and immune disorders. (wikipedia.org)
The healthy, transplanted stem cells can restore the bone marrow's ability to produce the blood cells the patient needs. (pallipedia.org)
Blood-forming stem cell transplants. (pallipedia.org)
A total of five patients received stem cells prepared from the peripheral blood (18-23 ×10 9 cells/case) four times before and after the transplantation (intervention group). (ac.ir)
The level of peripheral blood chimerism was determined by the incompatibility of HLA and using a PCR-flow cytometry combined method in the first, third, and twelfth-month after the transplantation. (ac.ir)
Blood, which requires extraction through apheresis, wherein blood is drawn from the donor (similar to a blood donation), and passed through a machine that extracts the stem cells and returns other portions of the blood to the donor. (wikipedia.org)
This demonstrates that the cells can produce new blood cells over a long term. (wikipedia.org)
Organization of basic and clinical scientists researching important issues in blood and marrow transplantation. (dmoztools.net)
NMDP research program focuses on improving clinical outcomes of blood stem cell transplantation. (dmoztools.net)
Provides information regarding blood and bone marrow transplants to treat a number of blood disorders and cancer. (dmoztools.net)
According to Pluristem CEO Zami Aberman, it was the first time ever that stem cells were injected into the muscle rather than into the body's blood system. (wikipedia.org)
From 1980-1997, Gale was Chairman of the Scientific Advisory Committee of the Center for International Blood and Marrow Transplant Research (CIBMTR), an organization of more than 400 transplant centers in over 60 countries worldwide working together to analyze and advance knowledge about blood cell and bone marrow transplants. (wikipedia.org)
From 1993-1999, Gale was Senior Physician and Corporate Director of Bone Marrow and Blood Cell Transplantation at Salick Health Care (SHC), Inc. in Los Angeles (now Aptium Oncology), a subsidiary of AstraZeneca. (wikipedia.org)
Gale has published over 1000 scientific articles and more than 20 books, mostly on leukemia (biology and treatment), transplantation (biology, immunology and treatment), cancer immunology and radiation (biological effects and accident response). (wikipedia.org)
For example, T cells capable of fighting cancer cells via cell-mediated immunity may be injected in the course of immunotherapy. (wikipedia.org)
Among several clinical trials that have reported that adult stem-cell therapy is safe and effective, powerful effects have been reported from only a few laboratories, infarcts as well as heart failure not arising from myocardial infarction. (wikipedia.org)
An example of this is the use of cells to replace cardiomyocytes after myocardial infarction. (wikipedia.org)
It should also be possible to isolate stem cells from the transplanted individual, which can themselves be transplanted into another individual without HSCs, demonstrating that the stem cell was able to self-renew. (wikipedia.org)
Electricity notes pdf This coincides with the recent interest of the World Health Organization (WHO) ( www.who.org) in cell and tissue transplants, and further stresses the need for adequate and timely information. (gaselectricity.in)
adult stem
According to the company's website, it extracts adult stem cells exclusively from postnatal placentas. (wikipedia.org)
engraftment
However, there are two main principles by which cells facilitate therapeutic action: Stem cell or progenitor cell engraftment, differentiation, and long term replacement of damaged tissue. (wikipedia.org)
Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition. (wikipedia.org)
this is the only form of stem-cell therapy that is widely practiced. (wikipedia.org)
Adult stem cell therapy for treating heart disease was commercially available in at least five continents as of 2007. (wikipedia.org)
Cell therapy originated in the nineteenth century when scientists experimented by injecting animal material in an attempt to prevent and treat illness. (wikipedia.org)
Today two distinct categories of cell therapy are recognized. (wikipedia.org)
The first category is cell therapy in mainstream medicine. (wikipedia.org)
Cell therapy can be defined as therapy in which cellular material is injected into a patient. (wikipedia.org)
The origins of cell therapy can perhaps be traced to the nineteenth century, when Charles-Édouard Brown-Séquard (1817-1894) injected animal testicle extracts in an attempt to stop the effects of aging. (wikipedia.org)
In 1931 Paul Niehans (1882-1971) - who has been called the inventor of cell therapy - attempted to cure a patient by injecting material from calf embryos. (wikipedia.org)
Bone marrow transplants have been found to be effective, along with some other kinds of human cell therapy - for example in treating damaged knee cartilage. (wikipedia.org)
In recent times, cell therapy using human material has been recognized as an important field in the treatment of human disease. (wikipedia.org)
The experimental field of Stem cell therapy has shown promise for new types of treatment. (wikipedia.org)
In mainstream medicine, cell therapy is supported by a distinct healthcare industry which sees strong prospects for future growth. (wikipedia.org)
Cell therapy is targeted at many clinical indications in multiple organs and by several modes of cell delivery. (wikipedia.org)
Hematopoietic stem cell transplantation (HSCT) is an established procedure for many acquired and congenital disorders of the hematopoietic system, including disorders of the immune system, and as enzyme replacement in metabolic disorders. (gaselectricity.in)
Gale has contributed to basic science and clinical research in bone marrow transplantation where he made contributions to understanding the immune-mediated anti-leukemia effects of transplants (graft-versus-leukemia [GvL]. (wikipedia.org)
He has also advanced understanding other complex immune effects of transplants in humans, like graft-versus-host disease and post-transplant immune deficiency. (wikipedia.org)
The clinical trial will ultimately include transplants to 30 subjects. (wikipedia.org)
The department performs about 80-100 transplants every year. (bookinghealth.com)
The BMDW database is only searchable by authorized transplanting physicians and search coordinators around the world. (wikipedia.org)
Active enhancement of tissue allografts with antilymphocyte serum and bone marrow. (ac.ir)
Adipose tissue (lipid cells), which requires extraction by liposuction. (wikipedia.org)
In practice, stem cells are identified by whether they can regenerate tissue. (wikipedia.org)
These cells then integrate into the site of injury, replacing damaged tissue, and thus facilitate improved function of the organ or tissue. (wikipedia.org)
In August 2016, Europe's Horizon 2020 Program awarded Pluristem an $8 million grant to cover a portion of its expenses in Europe for Pluristem's Phase III study of PLX-PAD cells in the treatment of critical limb ischemia. (wikipedia.org)
SBUH also encompasses Suffolk County's only Level 4 Regional Perinatal Center, state-designated AIDS Center, state-designated Comprehensive Psychiatric Emergency Program, state-designated Burn Center, the Christopher Pendergast ALS Center of Excellence, and Kidney Transplant Center. (wikipedia.org)
He also developed the bone marrow transplant program supported by the NIH. (wikipedia.org)
soluble factors
Cells that have the capacity to release soluble factors such as cytokines, chemokines, and growth factors which act in a paracrine or endocrine manner. (wikipedia.org)
In 2014, the European Medicines Agency recommended approval of limbal stem cells for people with severe limbal stem cell deficiency due to burns in the eye. (wikipedia.org)
In syngeneic transplants, patients receive stem cells from their identical twin. (pallipedia.org)
Two mechanisms exist to ensure that a stem cell population is maintained: Obligatory asymmetric replication: a stem cell divides into one mother cell that is identical to the original stem cell, and another daughter cell that is differentiated. (wikipedia.org)
Stochastic differentiation: when one stem cell develops into two differentiated daughter cells, another stem cell undergoes mitosis and produces two stem cells identical to the original. (wikipedia.org)
Stems cells are being studied in those with severe heart disease. (wikipedia.org)
However, the severe immunosuppression that bone marrow transplantation requires causes a significant risk of serious infections in patients with large scale blisters and skin erosions. (wikipedia.org)
a donor's healthy bone marrow reintroduces functional stem cells to replace the cells lost in the host's body during treatment. (wikipedia.org)
Many of these genes share substantial structural and functional similarity, but they are specialized to cell type and/or conditions under which they are normally produced. (wikipedia.org)
Such cells can construct a complete, viable organism. (wikipedia.org)
Research into stem cells grew out of findings by Ernest A. McCulloch and James E. Till at the University of Toronto in the 1960s. (wikipedia.org)
Research is underway to develop various sources for stem cells, and to apply stem-cell treatments for neurodegenerative diseases and conditions such as diabetes, heart disease, and other conditions. (wikipedia.org)
Research has been conducted on the effects of stem cells on animal models of brain degeneration, such as in Parkinson's, Amyotrophic lateral sclerosis, and Alzheimer's disease. (wikipedia.org)
As of 2008 clinical research at the University of Minnesota has included a bone marrow transplant to a 2-year-old child who is one of 2 brothers with EB. (wikipedia.org)
Describes services and research for fighting against malignancies by expanding the effectiveness and applicability of bone marrow transplantation. (dmoztools.net)
Although such attempts produced no positive benefit, further research found in the mid twentieth century that human cells could be used to help prevent the human body rejecting transplanted organs, leading in time to successful bone marrow transplantation. (wikipedia.org)
Wherever appropriate, patient numbers corresponding to the number of patients receiving a first transplant and transplant numbers reflecting the total number of transplants performed are listed. (gaselectricity.in)
Transplant rates, defined as the total number of HSCT per 10 million inhabitants, were computed for each country without adjustments for patients who crossed borders and received their HSCT in a foreign country. (gaselectricity.in)
The present study investigated the effect of donor stem cells on improving transplant survival and reducing the need to use repressive drugs in patients with kidney transplant. (ac.ir)
Five out of eight patients in the control group acutely rejected the transplant in comparison with two out of five patients in the intervention group. (ac.ir)
The evaluation of peripheral active chimerism in two patients with stable transplant and normal function showed that peripheral chimerism was detectable up to 3 months after transplantation. (ac.ir)
Indeed, at least four patients have died in the course of either preparation for or institution of bone marrow transplantation for epidermolysis bullosa, out of only a small group of patients treated so far. (wikipedia.org)
Provides information about bone marrow transplantation procedures offered and clinical trials involving Mayo Clinic patients. (dmoztools.net)
For the last two years prior to the merger, the three organisations had been working closely together and the merger was a natural move to work towards high-quality stem cell products worldwide for patients in need of a transplant. (wikipedia.org)
A Phase III trial of PLX-(PAD)-peripheral arterial disease cells in the treatment of critical limb ischemia has been cleared to start enrolling patients by the U.S. Food and Drug Administration. (wikipedia.org)
Stem cells can now be artificially grown and transformed (differentiated) into specialized cell types with characteristics consistent with cells of various tissues such as muscles or nerves. (wikipedia.org)
In May 2012, Pluristem reported that its experimental PLacental eXpanded cells were injected into the muscles of a 7-year-old Romanian girl undergoing treatment for bone marrow aplasia disease at the Hadassah Medical Center in Jerusalem. (wikipedia.org)
In addition to its use in bone marrow transplantation, total body irradiation has been explored as a treatment modality for high-risk Ewing sarcoma. (wikipedia.org)
Pluristem Therapeutics is an Israeli company engaged in the development of human placental adherent stromal cells for commercial use in disease treatment. (wikipedia.org)
Pluristem announced that the treatment led to a significant increase in the girl's red cells, white cells and platelets, effecting a reverse in her condition. (wikipedia.org)
In September 2012 Pluristem reported saving the life of a third bone marrow disease patient using its PLacental eXpanded cell treatment, again at Jerusalem's Hadassah Medical Center and again under the terms of compassionate use. (wikipedia.org)
Nevertheless, these cells are being investigated as the basis for a number of therapeutic applications, including possible treatments for diabetes and Parkinson's disease. (wikipedia.org)
peripheral blood
This phase II trial studies how well tacrolimus and mycophenolate mofetil works in preventing graft-versus-host disease in patients who have undergone total-body irradiation (TBI) with or without fludarabine phosphate followed by donor peripheral blood stem cell transplant for hematologic cancer. (clinicaltrials.gov)
Giving low doses of chemotherapy, such as fludarabine phosphate, and TBI before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells. (clinicaltrials.gov)
Language English If you are providing the blood stem cells for a transplant, they will either be collected from your bloodstream (peripheral blood) or from your bone marrow. (stemcelltherapy.me)
Investigators characterized CD34 + Lin - CD10 + lymphoid progenitors in the peripheral blood of allogeneic hematopoietic stem cell transplantation patients. (celltherapynews.com)
Transplantation of stem cells are taken from the bone marrow, peripheral blood or umbilical cord of healthy, matched donors. (wikipedia.org)
citation needed] In order to harvest stem cells from the circulating peripheral blood, blood donors are injected with a cytokine, such as granulocyte-colony stimulating factor (G-CSF), that induces cells to leave the bone marrow and circulate in the blood vessels. (wikipedia.org)
Complete recovery of immune function takes much longer, however-up to several months for autologous transplant recipients and 1 to 2 years for patients receiving allogeneic or syngeneic transplants. (stemcellcordblood.net)
The EGE is of the opinion that "support for public cord blood banks for allogeneic transplantations should be increased and long term functioning should be assured. (stemcellcordblood.net)
Researchers describe the natural history of clinical symptoms and brain imaging in two siblings with Acyl-CoA oxidase deficiency, including the younger sibling's response to allogeneic unrelated donor hematopoietic stem cell transplantation. (celltherapynews.com)
Voriconazole is used to treat invasive aspergillosis and candidiasis and fungal infections caused by Scedosporium and Fusarium species, which may occur in immunocompromised patients, including people undergoing allogeneic bone marrow transplant (BMT), who have hematologic cancers or who undergo organ transplants. (wikipedia.org)
Sometimes the transplanted cells from a donor can also make an immune response against the body's normal cells. (clinicaltrials.gov)
When a patient needs a transplant, the registry is searched to find a matching marrow donor or cord blood unit. (stemcellcordblood.net)
Cells of the donor strain are injected through a fine glass needle, either into the blastocoele cavity or into the center of the inner cell mass (the group of cells from which the fetus is derived). (thefreedictionary.com)
Until now insulin replacement is still the major therapy, because islet transplantation has been limited by donor availability and by the need for long-term immunosuppression. (jove.com)
Following the first sibling-donor cord blood transplant in 1988, the National Institute of Health (NIH) awarded a grant to Rubinstein to develop the world's first cord blood program at the New York Blood Center, in order to establish the inventory of stem cell units necessary to provide unrelated, matched grafts for patients. (wikipedia.org)
autologous stem
Treatment with LentiGlobin® is given as an autologous stem cell transplant. (healthcanal.com)
It is the most common cause of death worldwide.1 Conditions of cardiovascular disease include: The Stem Cells Transplant Institutein Costa Rica, uses adult autologous stem cells for the treatment of cardiovascular disease (heart disease). (stemcelltherapy.me)
CLL results in the build up of B cell lymphocytes in the bone marrow, lymph nodes, and blood. (wikipedia.org)
Less commonly, CLL may present with enlarged lymph nodes without a high white blood cell count or no evidence of the disease in the blood. (wikipedia.org)
Mesenchymal
Mesenchymal stem cells are specialized cells that naturally grow in our body and can differentiate into bone, cartilage or fat cells. (stemcelltherapy.me)
Using gain- and loss-of-function approaches, scientists demonstrated that let-7 markedly promotes osteogenesis and suppresses adipogenesis of mesenchymal stem cells in vitro . (celltherapynews.com)
Moreover, let-7 could promote ectopic bone formation of mesenchymal stem cells in vivo . (celltherapynews.com)
Primary rat articular chondrocytes and bone marrow-derived mesenchymal stem cells were cultured on the layers of bare poly(lactide-co-caprolactone) (PLCL) and mineralized PLCL nanofibers, respectively, for 7 days, and the biphasic cell-nanofiber construct was investigated at 4 weeks after implantation into nude mice. (celltherapynews.com)
Researchers investigated the reparative potential of human bone marrow-derived mesenchymal stem cells and traced their homing patterns following administration to mice with ischemia/reperfusion injury using whole body bioluminescence imaging. (celltherapynews.com)
Scientists investigated and compared the cellular responses of mesenchymal stem cells derived from bone marrow and synovium on combined silk scaffolds that can be used to determine the cell source most appropriate for tissue-engineered ligament. (celltherapynews.com)
The hematopoietic cells are able to go to the bone marrow through tracking mechanisms. (wikipedia.org)
ectopic
They develop spontaneously from germ cells in the gonads of certain mouse strains, or from cells in early embryos transplanted to ectopic sites. (thefreedictionary.com)
We developed and validated a fluorescent marking methodology for clonal tracking of hematopoietic stem and progenitor cells (HSPCs) with high spatial and temporal resolution to study in vivo hematopoiesis using the murine bone marrow transplant experimental model. (jove.com)
Hematopoiesis is the process by which all mature blood cells are produced. (wikipedia.org)
In vertebrates, the vast majority of hematopoiesis occurs in the bone marrow and is derived from a limited number of hematopoietic stem cells (HSCs) that are multipotent and capable of extensive self-renewal. (wikipedia.org)
Combining two-photon microscopy with fluorescent tracers, we successfully visualized the engrafted tissues at the single cell level in live mice over several months. (jove.com)
Imaging using confocal/two-photon hybrid microscopy enables simultaneous high resolution assessment of uniquely marked cells and their progeny in conjunction with structural components of the tissues. (jove.com)
Volumetric analyses over large areas reveal that spectrally coded HSPC-derived cells can be detected non-invasively in various intact tissues, including the bone marrow (BM), for extensive periods of time following transplantation. (jove.com)
Another kind of cell-the pluripotent stem cell of mouse teratocarcinomas-was found to give rise to normal tissues in adult chimeras after injection into the mouse blastocyst. (thefreedictionary.com)
All the differentiated tissues in the tumor arise from pluripotent stem cells known as embryonal carcinoma (EC) cells. (thefreedictionary.com)
When embryonal carcinoma cells are injected into a genetically marked host blastocyst, they continue to divide and participate in normal development, and give rise to fully differentiated cells in all tissues of the adult, including skin, muscle, nerve, kidney, and blood. (thefreedictionary.com)
The diagnosis of CLL is based on the demonstration of an abnormal population of B lymphocytes in the blood, bone marrow, or tissues that display an unusual but characteristic pattern of molecules on the cell surface. (wikipedia.org)
Thus, composite tissue structure is considered to be more immunogenic than solid organ transplants. (springer.com)
Shapiro RI, Cerra FB (1978) A model for reimplantation and transplantation of a complex organ: the rat hind limb. (springer.com)
Rubinstein specializes in immunogenetics, which encompasses the structure and function of genes that regulate immune responses, control the acceptance or rejection of tissue and organ transplants, and affect susceptibility to certain diseases. (wikipedia.org)
Genetic combinatorial marking using lentiviral vectors encoding fluorescent proteins (FPs) enabled cell fate mapping through advanced microscopy imaging. (jove.com)
The underlying mechanism involves multiple genetic mutations that results in rapid cell division. (wikipedia.org)
In addition, post-meiotic germ cells undergo a dramatic morphological reshaping process as well as a global epigenetic reconfiguration of the germ line chromatin-the histone-to-protamine switch. (jove.com)
Hematopoietic Stem Cell Transplantation (HSCT) involves intravenous infusion of stem cells to those who have either a damaged bone marrow or defective immune system. (wikipedia.org)
In ALL, both the normal development of some lymphocytes and the control over the number of lymphoid cells become defective. (wikipedia.org)
While cartilage, ligaments, and fat present low antigenicity, bone, muscles, nerves, and vessels present moderate antigenicity, and skin is the component that develops the most severe rejection because of the abundance of dendritic cells within the epidermis and dermis. (springer.com)
Then in laboratory conditions the stem cells are manipulated and corrected with gene technology. (wikipedia.org)
Experimental chimeras have been used to study a number of biological questions, including the origin and fate of cell lineages during embryonic development, immunological self-tolerance, tumor susceptibility, and the nature of malignancy. (thefreedictionary.com)
bloodstream
After entering the bloodstream, the stem cells travel to the bone marrow, where they begin to produce new white blood cells, red blood cells, and platelets in a process known as "engraftment. (stemcellcordblood.net)
This includes differentiation from a stem cell population, mitotic amplification, and meiosis. (jove.com)
Differentiation and proliferation of hematopoietic stem cells require a lot of energy and this energy is supplied by the mitochondria. (wikipedia.org)
This atypical molecular pattern includes the coexpression of cell surface markers clusters of differentiation 5 (CD5) and 23. (wikipedia.org)
In CLL, the lymphocytes are genetically clonal, of the B cell lineage (expressing marker molecules clusters of differentiation 19 and 20), and characteristically express the marker molecules CD5 and CD23. (wikipedia.org)
cancerous
In some individuals, the disease comes to light only after the cancerous cells overwhelm the bone marrow resulting in anemia producing tiredness or weakness. (wikipedia.org)
However, embryonal carcinoma cells from some other sources fail to integrate, but produce teratocarcinomas in the newborn animal or adult. (thefreedictionary.com)
Lance EM, Inglis AE, Figarola F et al (1971) Transplantation of the canine hind limb. (springer.com)
Canine periodontal ligament stem cells were transduced with adenoviral vectors containing bone morphogenetic protein 2 (BMP2/PDLSCs). (celltherapynews.com)
lineages
HSCs give rise to both the myeloid and lymphoid lineages of blood cells. (wikipedia.org)
Hematopoietic stem cells also are found in blood and bone marrow in adults and children. (stemcellcordblood.net)
HSCs are found in the bone marrow of adults, especially in the pelvis, femur, and sternum. (wikipedia.org)
Central nervous system (CNS) symptoms such cranial neuropathies due to meningeal infiltration are identified in less than 10% of adults and less than 5% of children, particularly mature B-cell ALL (Burkitt leukemia) at presentation. (wikipedia.org)
Bone marrow aspiration (the removal of a small sample of bone marrow through a needle for examination under a microscope) can also help doctors determine how well the new marrow is working. (stemcellcordblood.net)
Diagnosis is typically based on blood tests and bone marrow examination. (wikipedia.org)
involves
Aggregation chimeras are produced by a technique that involves removing the zonae pellucidae from around 8-16 cell embryos of different strains of mice and pushing the morulae together so that the cells can aggregate. (thefreedictionary.com)
germ cells
During spermatogenesis in mammals and in Drosophila melanogaster, male germ cells develop in a series of essential developmental processes. (jove.com)
Doctors evaluate the results of various blood tests to confirm that new blood cells are being produced and that the cancer has not returned. (stemcellcordblood.net)
Hematopoietic stem cells, however, can mature into different types of blood cells in the body. (stemcellcordblood.net)
Blood-forming stem cells are important because they grow into different types of blood cells. (stemcelltherapy.me)
Hematopoietic stem cells give rise to blood cells. (wikipedia.org)
GM-CSF stimulates production of white blood cells. (wikipedia.org)
These cells do not function well and crowd out healthy blood cells. (wikipedia.org)
Hematopoietic stem cells (HSCs) are the stem cells that give rise to blood cells through the process of haematopoiesis. (wikipedia.org)
It must balance enormous production needs (more than 500 billion blood cells are produced every day) with the need to precisely regulate the number of each blood cell type in the circulation. (wikipedia.org)
Balanced (Bala) HSCs repopulate peripheral white blood cells in the same ratio of myeloid to lymphoid cells as seen in unmanipulated mice (on average about 15% myeloid and 85% lymphoid cells, or 3 ≤ ρ ≤ 10). (wikipedia.org)
Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the development of large numbers of immature lymphocytes. (wikipedia.org)
The excessive immature lymphocytes in the bone marrow interfere with the production of new red blood cells, white blood cells, and platelets. (wikipedia.org)
Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). (wikipedia.org)
Diagnosis is typically based on blood tests finding high numbers of mature lymphocytes and smudge cells. (wikipedia.org)
Normal B lymphocytes consist of a stew of different antibody-producing cells, resulting in a mixture of both kappa- and lambda-expressing cells. (wikipedia.org)
These B cells resemble normal lymphocytes under the microscope, although slightly smaller, and are fragile when smeared onto a glass slide, giving rise to many broken cells, which are called "smudge" or "smear" cells. (wikipedia.org)
Normal lymphoblasts develop into mature, infection-fighting B-cells or T-cells, also called lymphocytes. (wikipedia.org)
This process indicates that, subsequent to bone marrow transplantation, symmetrical cell divisions into two daughter HSCs must occur. (wikipedia.org)
Stem cell self-renewal is thought to occur in the stem cell niche in the bone marrow, and it is reasonable to assume that key signals present in this niche will be important in self-renewal. (wikipedia.org)
These genes, in turn, increase the risk that more mutations will occur in developing lymphoid cells. (wikipedia.org)
mesoderm
They are derived from mesoderm and located in the red bone marrow, which is contained in the core of most bones. (wikipedia.org)
ALL emerges when a single lymphoblast gains many mutations to genes that affect blood cell development and proliferation. (wikipedia.org)
More significantly, the absence of cardiac stem cells indicates that heart muscle that is lost due to a heart attack cannot be replaced. (stemcelltherapy.me)
Vectors encoding five different FPs: Cerulean, EGFP, Venus, tdTomato, and mCherry were used to concurrently transduce HSPCs, creating a diverse palette of color marked cells. (jove.com)
Aggressive treatment with antibiotics is required and bone marrow transplant is common. (wikipedia.org)
Stem cell transplantation may be used if the disease recurs following standard treatment. (wikipedia.org)
Engraftment usually occurs within about 2 to 4 weeks after transplantation. (stemcellcordblood.net)
The two cell types were transfected with green fluorescent protein to evaluate their fate after implantation in an intraarticular environment of the knee joint. (celltherapynews.com)
cells in diabetic mice, and that the anti-hyperglycemic efficacy of this combination was better than that of 1-deoxynojirimycin (DNJ) or polysachharide alone. (jove.com)
Investigators induced dopaminergic (DA) neurons using scalable culture conditions on human laminin fragment, and the sorted CORIN + cells expressed the midbrain DA progenitor markers, FOXA2 and LMX1A. (celltherapynews.com)
epigenetic changes
Gene expression can be stably altered through epigenetic changes which not only allow cells and organisms to quickly respond to changing environmental stimuli but also confer the ability of the cell to "memorize" these encounters once the stimulus is removed. (jove.com)
These rearrangements result in increased expression of blood cell development genes by promoting gene transcription and through epigenetic changes. (wikipedia.org)
Two-photon microscopy has enabled the study of individual cell behavior in live animals. (jove.com)
Transplantation is a simple process. (wikipedia.org)
Stem cell-filled implants helped repair spinal cord damage in animals, according to a study led by UC San Diego scientists. (stemcelltherapy.me)
This view was first challenged by the 2002 discovery by the Muller-Sieburg group in San Diego, who illustrated that different stem cells can show distinct repopulation patterns that are epigenetically predetermined intrinsic properties of clonal Thy-1lo Sca-1+ lin− c-kit+ HSC. (wikipedia.org)
If there is a mutation in the protein, that means that the mitochondria metabolism most likely will be altered and will not be able to provide enough energy to the hematopoietic stem cells. (wikipedia.org)
genetically
An individual animal or plant made up of cells derived from more than one zygote or otherwise genetically distinct. (thefreedictionary.com)
In addition, all the CLL cells within one individual are clonal, that is, genetically identical. (wikipedia.org)
Four dimensional (three-dimensional (3D) plus time) information of individual cells was obtained from this imaging. (jove.com)
On average, the transport time for stem cells from the hospital to CBR's lab is 19 hours. (stemcellcordblood.net)


ClashAuto isn't only the most environment friendly Clash of Clans bot; however it is the safest as effectively! We now have by no means had a person banned from the sport as our integrated anti ban technology ensures you keep undetectable at all times. You feel like you've let your other clan members down, despite the fact that we all have these days. Learn how to join ANY Clash of Clans Account to your pc, arrange BlueStacks and the Bot. It will tell you every little thing you need to find out about the way to start botting. Different thing that we wish to see is a brand new campaign recreation" or a weekly little quest in the goblins campaign", things that would help the players improve your self within the sport. Try our very simple 3 steps tutorial. ClashFarmer is the one COC bot that doesn't require to register in any discussion board.
When finding opponents, there are a few things you want to take into account earlier than you start dropping troops. First, look at their City Hall level – if it's miles decrease than yours, you may be getting a smaller lower of the spoils. You'll get to see exactly how many assets are available for plundering. At the very least, you need to have the ability to earn back the sources you spend on troops. If resources are all you are after, it is usually extra worthwhile to send in a handful of goblins and ultimately lose the battle than win a full-blown assault that prices numerous sources.
That is the top of this countdown, but if you would like more, take a look at our observe-up article: 10 MORE tips for Conflict of Clans! Can you spend all day attacking individuals? Sure. However the game is what you make of it and there's no need to try this. It's undoubtedly a go at your personal pace type of game. IHS Expertise analyst Jack Kent stated the flat revenue indicated new challenges. Skeleton Traps, which spawn undead skeleton defenders that quickly stall the enemy for tower fireplace and might be set to focus on either ground or air items, can be found at degree eight.
Think about this your crash course in Conflict of Clans, everything from what to anticipate after putting in to what system is best for maximum enjoyment. So… not that much. I feel Supercell will tune the matchmaking algorithm to match lopsided (engineered) bases more towards each other. Every thing else would not be attainable to do anyhow. Cell Cellphone as Joystick. Obtain the separate software to experience COC like never earlier than! Conflict of Clans has had nice success on iOS. We'll see if the Android version is as profitable, however in the meantime, you possibly can enjoy your onerous work and progress on both your iOS and Android system!
Parents need to know that Conflict of Clans is a strategic action game that pits players towards each artificial-intelligence characters and real-world opponents. The app's license agreement requires all gamers to be at least 13; teenagers thirteen to 17 are speculated to have a guardian comply with the phrases, nevertheless it's on the glory system. There are frequent battles with explosions and the cries of defeated troopers, but there isn't a graphic violence. The sport's core element is its multiplayer mode, whereby gamers can assault the villages of different gamers (and defend their very own), but they don't communicate with each other immediately when these attacks occur – although there's a international and intra-clan chat functionality when players are in their very own villages. Fortifying a village and building a military price money, and the sport uses in-app purchases to assist players purchase in-game forex to upgrade quicker.


text:
Q: How can I inherit an MFC dialog box? I have created a dialog box (cMyDialog). I am planning to duplicate cMyDialog and call it cMyDialog2. How can I do inheritance in MFC? I want cMyDialog2 to inherit all the IDDs from cMyDialog1 so that I do not have to copy and paste the code from cMyDialog1 to cMyDialog2. The purpose of cMyDialog2 is to inherit all the functions from cMyDialog1 and to add some extra functions in it.

Thank you very much for your reply. I am not quite sure about the IMPLEMENT_DYNAMIC. Below is a short snippet of my code. Can you please review it and help me if I misunderstood the macro?
// cMyDialog1.cpp : implementation file

cMyDialog1::cMyDialog1(void * pMsgData, CWnd* pParent /*=NULL*/): CDialog(cMyDialog1::IDD, pParent)

{ //codes....
}

BOOL cMyDialog1::OnInitDialog()

{
    CDialog::OnInitDialog();
...
}

//cMyDialog2.cpp

cMyDialog2::cMyDialog2(void * pMsgData, CWnd* pParent /*=NULL*/)
    : CMyDialog1(cMyDialog2::IDD, pParent)

{ //codes....
   IMPLEMENT_DYNAMIC(cMyDialog2, cMyDialog1)
}

I am able to inherit from CMyDialog via the DECLARE_DYNAMIC and IMPLEMENT_DYNAMIC method. Thanks a lot for your help, Adam.
But I was unable to get the second part of my question to work. I wanted to add some extra functions in the child dialog box, CMyDialog1, such as adding a "Save As" button, but I was unable to do it. Is it because CMyDialog1 is an inherited dialog from CMyDialog and hence, I can't add in new functions? How can I add new functions in the inherited dialog box?

A: Yes you can inherit from a CDialog-derived class. You just need to add a few macros like DECLARE_DYNAMIC and a few others to satisfy MFC. Here is an example. You can use this as a starting point:
In the .h file:
class cMyDialog2
  : public cMyDialog
{
  DECLARE_DYNAMIC(cMyDialog2)

pulic:
  cMyDialog2();
  virtual ~cMyDialog2();

protected:
  DECLARE_MESSAGE_MAP()
};

In the .cpp file:
#include "cMyDialog2.h"

IMPLEMENT_DYNAMIC(cMyDialog2, cMyDialog)

BEGIN_MESSAGE_MAP(cMyDialog2, cMyDialog)
END_MESSAGE_MAP()

cMyDialog2::cMyDialog2()
{
}

...etc.

A: This maybe considered as addendum to Adam Piece answer. It is also important to understand the role of DoDataExchange() when deriving from another dialog. Either the derived class (cMyDialog2) shall not implement this function or if it is implemented (recommended) it should call base version of it like below:
void cMyDialog2::DoDataExchange(CDataExchange* pDX)
{
    CDialog::DoDataExchange(pDX);
    cMyDialog::DoDataExchange(pDX);
}

If this is not done correctly, the controls on the dialog will not be created and the dialog may crash as a result when invoked/executed.

redpajama_set_name: RedPajamaStackExchange


A n environmental television series made for Mozambican Television and financed by the Irish Government on the endangered marine life in the waters off the coast off Mozambique. The series was for a young audience and shown both on television and in educational projects throughout coastal communitiesuses. Two young Mozambican presenters - Mozambique's first generation of trained dive masters - are sent on a series of missions to learn more about the the wonders of their waves and the endangered marine specias that live off the Mozambican coast. These first episodes focus on the Dugong. (Portuguese language version only).
Watch Episode 1 (Missions 1,2 and 3) in full.
Watch Episode 2 (Mission 4 and 5) in full.
The beginning of the series - setting up the premise of an under-water command boat sending two 'aquatic adventurers' on missions to investigate Mozambique's endangered marine life.
The two 'aquatic adventurers' are sent on a mission from head control to find a dugong.
The two 'aquatic adventurers' spot a dugong on the surface and dive in the hope of watching it under water. They introduce the Mozambican viewer to the under-water world off their coastline, but not the elusive dugong.
The second dive of the aquatic adventurers. This time from a dhow to make less noise. They get a rare glimpse of a lone male before it is scared off by a motor boat.
The fourth dive. After a series of failed attempts, here on the sea grass beds, the Aquatic Adventurers observe the lone male dugong feeding. This exceedingly rare underwater footage of one of the few remaining dugong in East Africa was shot by cameraman and Co-Director James Ewen and came at the end of six weeks filming from a dhow in the Bazaruto Arquipelago.
After a brief recap, the final episode in the first series takes the young presenters into the community to find out more about the relationship between the islanders and the dugong.


text:
Frank Sinatra – "The Lady Is a Champ" (1968)
March 9, 2011 at 6:34 am	(Frank Sinatra, Music, The Beatles)
What was labeled "Apple 1" (the very first Apple Records recording after The Beatles' own "Hey Jude"/"Revolution" single), this extremely rare, private re-recording of "The Lady Is a Tramp" (retitled "The Lady Is a Champ") was made by Sinatra in 1968 as a favor to The Beatles. Longtime Sinatra lyricist Sammy Cahn wrote new lyrics to the song as a birthday gift to Ringo Starr's wife Maureen.
Only one copy was made, and the tape and masters were destroyed. Since there is only one copy, and since Sinatra and the Beatles were both involved, this may be among the most valuable records in the world.
Note: Since this is a bootlegged copy and not from the original master tapes, the sound is not the greatest.

redpajama_set_name: RedPajamaCommonCrawl


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text:
Desperation Stalks Zimbabwe's White Farmers
Mkepile Mabuse, CNN, Sept. 22. 2009
A desperate Zimbabwean farmer fighting to hold onto his land–a year after the country's political rivals pledged to govern jointly–fears he will eventually lose to politics and violence.
Charles Lock is one of an estimated 400 farmers who have remained in the country despite President Robert Mugabe's policy of redistributing white-owned farms to landless blacks.
"Why do they want to remove me when I've complied with everything they want? What more do they want other than for me to pack my bags and leave and if that's the case, then admit that that is the policy. Pass a law: no whites are allowed to farm. Then it makes it clear," Lock said.
Since 2000, Mugabe's controversial land reform program has driven more than 4,000 commercial farmers off their land, destroying Zimbabwe's once prosperous agricultural sector.
"When the land reform program began, we decided we were not going to have a confrontational attitude; that we would actually go along with this program because it was the only way that this whole thing would be sorted out. So I voluntarily gave away my own farm and moved onto my father-in-law's farm," Lock said.
That was in 2002. A year later the government came knocking on his door again, he said, demanding more land.
Lock told CNN he eventually gave up 70 percent of his father-in-law's farm, which he then owned. Now an army general is demanding Lock's remaining 30 percent.
When Zimbabwe's new unity government was formed–with Mugabe's ZANU-PF and Morgan Tsvangirai's Movement for Democratic Change–in February this year, the general allegedly posted soldiers on Lock's farm. The farmer said he stopped farming and trade at gun point.
When CNN visited Lock's farm this month, workers were standing idle. Maize and tobacco, which Lock said is worth more than U.S. $1 million, lay in storage.
On another farm, Ben Freeth's fight for his land has just escalated to another level.
Freeth has been repeatedly beaten, arrested and harassed. Now his farmhouse and that of his father-in-law have been gutted by a mysterious fire.
Freeth could not say for sure that this is arson but told CNN that the group of ZANU-PF youths who have occupied his farm have repeatedly threatened to burn his house.
Freeth and his father-in-law Mike Campbell are among a group of Zimbabwean farmers who won the right to remain on their land at a southern African tribunal.
But Mugabe has declared the ruling null and void and pulled out of the tribunal. Farmers cannot contest land issues in Zimbabwe and approaching international courts has thus far not worked either.
When CNN interviewed Mugabe's minister of state, Didymas Mutasa, about the disregard for human and property rights on the farms, he blamed the farmers for the violence, saying landless blacks are getting frustrated with their refusal to relinquish their land.
"Human rights are beginning to be seen now because they benefit the whites, and when they were affecting blacks badly as they did the likes of us, it didn't matter and nobody raised anything about those human rights.
"And sometimes we say, good heavens, if that is the kind of human rights you are talking about, you better keep them away from us; we don't want to see them," he told CNN.
But it is black farm workers who are caught in the cross fire. They continue to bear the brunt of the land reform program by repeatedly being beaten and intimidated. Some have even been killed.
Many farmers and farm workers we spoke to say they are in a worse position now under the unity government than they were before.
Lock said: "When ZANU-PF was in power, you had hawks and doves in government and the doves were approachable and often helped us. But now that these positions are being shared with Mr. Tsvangirai's MDC, Mr. Mugabe has only appointed hawks to his cabinet who insist on continuing the land reform program. And when it comes to the MDC, the land issue seems to be a hot potato they do not want to touch. I have asked Mr. Tsvangirai to intervene but nothing is happening."
Topics: Zimbabwe
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text:
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        <link href="stile.css" media="screen" rel="stylesheet" />

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        if ($dati == "") $dati = "sp";

        $year = $_GET['year'];
        $month = $_GET['month'];
        if ($year == "") $year = date('Y');
        if ($month == "") $month = date('m');

        $months = array('', 'Gennaio', 'Febbraio', 'Marzo', 'Aprile', 'Maggio', 'Giugno', 'Luglio', 'Agosto', 'Settembre', 'Ottobre', 'Novembre', 'Dicembre');

        function addSubmitForm($dati,$months){
                echo "
Eseguire una ricerca per visualizzare le statistiche:
\n";
                echo "<form id=\"myform\" name=\"myform\" method=\"get\">\n";

                $datiDecoded = utf8_decode(urldecode($dati));

                echo "  <input type='hidden' name='dati' value='$datiDecoded' />";
                echo "  <select id='month' name='month'>;\n";
                for ($i = 1; $i <= 12; $i++){
                        $mon = ($i < 10) ? '0'.$i : $i;
                        echo "          <option id='". $months[$i] ."' value='".$mon."'";
                        if ($i == date("n")) echo " selected='selected'";
                        echo '>'.$months[$i].'</option>';
                }
                echo "  </select>";

                echo "  <select id='year' name='year'>";
                for ($i = 2012; $i <= date('Y'); $i++) {
                        echo "<option id='".$i."' value='".$i."'";
                        if ($i == date('Y')) echo " selected='selected'";
                        echo ">" . $i . "</option>";
                }
                echo "  </select>";
                echo "  <input type=\"submit\" value=\"Submit\" />";
                echo "</form>";
        }

?>

<a href="index.php?dati=sp" <?php if ($dati == "sp") echo "class=\"current\""; ?>>Dati per SP

<a href="index.php?dati=user" <?php if ($dati == "user") echo "class=\"current\""; ?>>Dati per utente

<a href="index.php?dati=questionario" <?php if ($dati == "questionario") echo "class=\"current\""; ?>>Dati per questionario IDEM

Statistiche di utilizzo dell'IdP

Identity provider installato nell'ambito del progetto GARR IdP-in-the-Cloud

                <?php
                include_once("db.php");

                if (!mysql_connect($sbhost, $dbuser, $dbpasswd))
                        die("Impossibile connettersi al database");
                if (!mysql_select_db($dbname))
                        die("Impossibile selezionare il database");
                $sps_names = array();
                $result = mysql_query("SELECT sp, name FROM sps");
                while($row = mysql_fetch_row($result)) {
                        $sps_names[$row[0]] = $row[1];
                }
                mysql_free_result($result);
                ?>

                <?php
                if ($dati == "sp") {
                        addSubmitForm($dati,$months);

                        $query1 = "SELECT DISTINCT sp FROM logins WHERE data LIKE '$year-$month-%';";
                        $query2 = "SELECT data, sp, SUM(logins) from logins WHERE data LIKE '$year-$month-%' GROUP BY data, sp";
                        $title = "Numero di login per data e per SP";
                        $titlepie = "\"Login a:
 \" + item + \"
 in data:
 \" + data";
                        $graph = True;

                } elseif ($dati == "user") {
                        addSubmitForm($dati, $months);

                        $query1 = "SELECT DISTINCT user FROM logins WHERE data LIKE '$year-$month-%';";
                        $query2 = "SELECT data, user, SUM(logins) from logins WHERE data LIKE '$year-$month-%' GROUP BY data, user";
                        $title = "Numero di login per data e per utente";
                        $titlepie = "\"Login di:
 \" + item + \"
 in data:
 \" + data";
                        $graph = True;

                } elseif ($dati == "questionario") {
                        addSubmitForm($dati, $months);

                        $result = mysql_query("SELECT SUM(logins) from logins WHERE YEAR(data) = ".$year." AND MONTH(data) = ".$month);
                        $row = mysql_fetch_row($result);
                        $totnum = $row[0];
                        mysql_free_result($result);
                ?>

Il numero totale di login nel <?php echo $months[intval($month)]; ?> <?php echo intval($year); ?> è:
                        <?php
                                if ($month > date('n') && $year == date('Y')){
                                } else {
                                        echo "$totnum";
                                }
                        ?>

                <?php
                        $query1 = "SELECT \"Logins\" as ID FROM dual";
                        $query2 = "SELECT sp, SUM(logins) from logins WHERE YEAR(data) = ".$year." AND MONTH(DATA) = " . $month . " GROUP BY sp";
                        $title = "Numero di login per mese e per SP";
                        $titlepie = "";
                        $graph = False;
                }

                $result = mysql_query($query1);
                $i = 0;
                $items = array();
                while($row = mysql_fetch_row($result)) {
                        $curitem = $row[0];
                        if ($dati == "sp" and array_key_exists($curitem, $sps_names)) {
                                $curitem = $sps_names[$curitem];
                        }
                        $items[] = $curitem;
                }
                mysql_free_result($result);

                if ($graph) {
                        if ($month > date('n') && $year == date('Y')){
                                echo "
DATA NON VALIDA!
";
                        }
                        else {
                ?>

 Statistiche di <?php echo $months[intval($month)]; ?> <?php echo intval($year); ?> sull'utilizzo dell'IdP raggruppate per data e per
                                <?php
                                        if($dati == 'sp') echo "service provider";
                                        elseif ($dati == 'user') echo "utente";
                                ?>:

                <?php
                        }
                }
                ?>
                <?php
                        if ($month > date('n') && $year == date('Y')){
                                echo "
DATA NON VALIDA!
";
                        }
                        else {
                ?>

                <?php
                }
                ?>

redpajama_set_name: RedPajamaGithub


text:
Linnets' boss calls display 'a disgrace'
Published: 7:40 PM August 16, 2009 Updated: 10:54 PM October 10, 2020
Paddy Davitt King's Lynn1, Stocksbridge 3: King's Lynn boss Carl Heggs admitted the buck stops with him after a shambolic opening-day Unibond Premier Division defeat to newly-promoted Stocksbridge Park Steels.
King's Lynn boss Carl Heggs admitted the buck stops with him after a shambolic opening-day Unibond Premier Division defeat to newly-promoted Stocksbridge Park Steels.
Heggs' remodelled squad emerged in front of a bumper 1,047 home crowd basking in bright sunshine buoyed by a wave of optimism fuelled by an encouraging pre-season and the infectious self-confidence of Lynn's straight-talking boss.
Fast forward 90 minutes and the only positive left was the sun in the sky. Sections of the home support had started to drift away long before the final whistle. The wave of optimism had crashed against the rocks of reality, and even Heggs' usually brash persona was unable to soften the blow of watching his side self-destruct.
Lynn frontman Gareth Sheldon opened his league account for the club with just four minutes gone - a trademark poacher's finish inside the six-yard box.
Brian Cusworth struck back late in the half before Andy Ring and Richard Stirrup latched onto hopeful punts forward after the break to burst clear and slot past Jason White having bamboozling Lynn's static central defensive duo.
"I feel like I have let everybody down," said Heggs. "Unfortunately I can't go on the pitch and change it. My team is as fit as they will ever be, as organised as they will be, has good players in it and we've had a decent pre-season. You saw none of that. What's shocking is not one player showed anything.
"They've made me look rubbish and I'm embarrassed to be the manager of King's Lynn. The thing with football is you always get an opportunity and ours comes around on Tuesday in the form and shape of Matlock. We have to make sure we have a reaction."
Heggs labelled Lynn's surrender his lowest moment since moving into coaching.
"The worst ever," he said. "In the two years or 18 months I was at Redditch we gave our all. We might have lost two or three nil to good sides because they pay more money, but that is the worst display I have ever seen since coming into coaching and I didn't expect it - I really didn't.
"We just fell away and crumbled to a side who, no disrespect to them, were absolutely shocking, but it just shows how bad we were. The players should have a long look at themselves.
"We were flat and that was unacceptable. There was no urgency, no one tried to get us going and we were so predictable. It was just a disgrace."
Heggs was in no mood to spare any of his under-performing squad.
"Owen (Story) who has been electrifying in pre-season was awful," he said. "The back four, shocking, absolutely all over the place - and that kills me. I pieced together a side that I thought can do the business over the course of this season. Well, on that performance we are going to struggle.
"We've got lads who have won the Conference North, the keeper has played 70-odd Football League games, but too many were all over the shop. Joe Magunda was at fault for the first goal. He tries to go through three players, lost the ball and vacated his area in the process, allowing their lad to run through into the box and cross for his mate to toe-poke home.
"Then how you get can beat by one ball over the top like we did for the second and third goals is just unbelievable. To be fair, the lads are devastated but they have to stomach that and come back."
Heggs must now lift his dejected troops for the trip to Matlock tomorrow - the Derbyshire side also aiming to recover from a 2-0 opening day defeat at Guiseley.
"I want to see what they've got now," said Heggs. "Yeah, we may have lost the first but we can hit back and go on a run. I can't tell you how deflated I am but it's my job to pick them back up and make sure I get a response and take it from there."
t Lynn: White, Magunda, Murray (Martin 82), Johnson (Smith 58), McAughtrie, Boyce, Story, Lloyd, Sheldon, Birley, Beswick (Green 58). Subs (not used): Webb, Whatsize. Goal: Sheldon (4)
t Stocksbridge: Scott, Green, Schofield, Dawson, Lovell, Hawes, Ring (Stirrup 75), Telling, Cusworth (Riley 48), Ward, Vardy. Subs (not used): Wilkinson, Cockerill, Hewitt. Goals: Cusworth (39), Ring (54), Vardy (81)
t Referee: I Dudley. Att: 1,047


text:
Deseret NewsEntertainment
A new high-profile Netflix documentary features music by this Utah native
Chad Cannon's score for 'American Factory' captures the humor and worry at the heart of an unusual Rust Belt reclamation
By Court Mann @TheCourtMann
Published: May 15, 2019 7:00 am
View 4 Items
Provided by Chad Cannon
Chad Cannon, center, working on a film score. Cannon wrote the music for the new Netflix documentary "American Factory."
The big awards, acquisitions and headlines from Sundance 2019
SALT LAKE CITY — When Chad Cannon began creating music for "American Factory," the culture clash at the documentary's core felt familiar.
The film, which premiered at this year's Sundance Film Festival and won the festival's directing award for U.S. documentaries, is coming to Netflix through Barack and Michelle Obama's new production company, Higher Ground Productions, where it will be the company's first release. "American Factory" shows a manufacturing plant's rebirth near Dayton, Ohio. The plant once belonged to General Motors — which laid off thousands of nearby townspeople when it closed in 2008 — and gets purchased by Fuyao Glass America, a Chinese company. The new owners rehire many of the locals whom GM laid off a decade earlier.
A nice redemption story, right? Not so fast.
Fuyao tries to integrate its Chinese and American workforces, even bringing over hundreds of Chinese workers to the American plant. At one point, the film also follows a group of new American employees as they visit one of the company's plants in China.
Chad Cannon, the composer of "American Factory."
"And they're seeing how these Chinese factory workers are very militant," Cannon told the Deseret News. "And in the company's morning warmups, it feels like they're in bootcamp — they line up, and they shout off their numbers. This kind of thing doesn't happen in American plants, at least not at their company."
Cannon, who grew up in Salt Lake City, served a mission in Japan for The Church of Jesus Christ of Latter-day Saints. Later on, he also interned at a Japanese industrial plant. The militancy shown in "American Factory" really brought him back. Cannon also runs the Asia / America New Music Institute, a chamber music group that does cultural diplomacy tours throughout Asia. His newest project, for example — the studio album "The Dreams of a Sleeping World" — is an hour-long suite of orchestral music paired with 10 paintings by artist Oscar Ōiwa. (That project comes to the Salt Lake Public Library on May 20.) In many ways, the composer was the ideal person to create the score for "American Factory."
In a review for IndieWire, Eric Kohn wrote, "'American Factory' shifts from an optimistic portrait of a Chinese rescue mission to a dispiriting comedy of errors, like an episode of 'The Office' for fans of 'The World Is Flat.'"
The documentary, Kohn added, "unfolds as a fascinating tragicomedy."
"I was given a chance to write music that sort of commented on that," Cannon said. "We tried not to make it too comedic, or else it becomes ridiculous, but the first chapter of the movie is pretty funny, as the American workers are confronted directly with how the Chinese management thinks, and vice versa."
Not that it's all funny. The Hollywood Reporter wrote, "The underlying message through the entire documentary is that the American Dream failed in Dayton when GM left … and the false hope offered by Fuyao might be in some ways worse."
Once it moves past the comedy, "American Factory" chronicles the American workers' efforts to unionize. Fuyao's founder/chairman, Cao Dewang, wants to stop the unionizing, and even threatens to leave town if he doesn't get his way.
Cannon, who got his start in Hollywood working on orchestral scores for "The Hobbit" trilogy, "Godzilla" (2014) and "The Secret Life of Pets," said the score in "American Factory" happened remarkably quickly. After getting the film's final cut, Cannon said he had three weeks to deliver the final score.
"And we're talking an hour of orchestral music," he explained. "So that's a lot of pages of notes."
Luckily, Cannon had a lot of help. He said outsiders often don't realize how collaborative film scoring really is. From the initial writing to the orchestral transcribing to the recording to the editing and mixing, the process is kind of like, well, a factory.
"We say as film composers, the best film scores are the ones that you don't even notice," Cannon said. "We hope that our music is just contributing to tell a story. And we recognize that music is just one part of the story."
If you go …
What: Chad Cannon's "The Dreams of a Sleeping World" screening
When: May 20, 7 p.m.
Where: Salt Lake City Public Library Auditorium, 210 E. 400 South
How much: Free
Web: chadcannonmusic.com
Court Mann Court Mann is the assistant Arts & Entertainment editor.
@TheCourtMann
cmann@deseretnews.com
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Entertainment July 12, 2019 Concert review: Is Hugh Jackman the 'Greatest Showman'?
Entertainment July 10, 2019 Dancing rules in this year's Utah Festival Opera productions of 'Newsies,' 'West Side Story' and 'Mary Poppins'
Entertainment July 11, 2019 Before Utah shows, Hugh Jackman's coffee company sets up shop in downtown Salt Lake


A few weeks ago our oven failed to preheat and maintain temperature properly. I called our local repair shop and the next day the appliance doctor made a house call, diagnosing the ailment as a bad PCB Assembly Board.
Last Wednesday, I spoke with the repair shop and was informed the part was backordered. In fact, each of the shop's three suppliers said the manufacturer (in this case LG) was clean out of them. I snarkily suggested to the shop manager he call my wife and explain why she won't be able to cook the turkey for her visiting family, or better yet, to invite her to bake the turkey at his house. I can be a real jerk sometimes.
To his credit, the guy called my bluff and replied that indeed my wife could cook the turkey at his house. And, he was nice about it. The Book of Proverbs says something about how showing kindness to your enemy heaps burning coals upon his head. I'm pretty sure this is the kind of thing Solomon was talking about. And, compounding my shame, he offered the part number (EBR74164802) in case I wanted to try to find the item myself. Even worse, he forgave the diagnostic trip charge. Sometimes I hate myself.
I found one on Ebay. Elapsed time: < 30 seconds.
This week is Thanksgiving, a season for reflecting on the relationships and blessings for which we are grateful. I once knew a chiropractor whose business card said, "BE THANKFUL" on the back – white font on a green background. When I inquired of his receptionist as to why, her reply was succinct and instructive – "Because you should," she said.
I must confess a bit of a funk over the last several months. Without going into detail regarding source or symptom, I can candidly say I haven't been myself lately, having been preoccupied with a sense of obligation concerning just about everything I do. Feeling obligated will take the fun out of anything. Of course, I don't mean the good kind of obligation, like being obligated to care for the poor and loving one another as we love ourselves. I'm talking about the bad kind, the toxic kind, the kind we impose upon ourselves through resentment and joylessness, the kind that grows in acidic soil, fertilized with myopia and thanklessness.
Like that proverbial slowly boiled frog, it (the funk) happened gradually, so gradually that I was taken completely unawares. As the song says, it was a slow fade.
Toxic obligation says yes to everything that is asked of you (and many things that are not) and executes them void of joyfulness and contentment. It is birthed in thanklessness, which is why it is impossible to be thankful and simultaneously live in such a state. If it is a kind of Pauli Exclusion Principle that prohibits them from occupying the same space, perhaps gratefulness is the answer.
So, what does this have to do with my oven? Simply that an attitude of thankfulness would have gone a long way toward both the repair shop manager and me having a better day. While I was harping about being inconvenienced (God forbid we would have to roast the turkey in a portable roaster) a billion people were facing the day without clean water. Certainly, a greater appreciation for life's blessings would have been more in keeping with the truly inconsequential nature of the problem.
So, it's time to do better. If you're already an ardently thankful individual, I'm happy for you. But for those of us for whom fervent and sustained thankfulness is elusive, I offer this tried and true starting place: let's count our blessings. Just to get things rolling, I'll go first.
I am thankful for Rhonda, my wife. She is the strongest, most steadfast and loving person I will ever know. That she is in love with this flawed man after 33 years is a marvel to me, and I am forever grateful for her.
I am thankful for my family. My adult children, despite them rolling their eyes behind my back from time to time, love their parents deeply. My grandchildren think I hung the moon.
I am thankful for my friends. We drive each other crazy at times, but your faithfulness is a treasure.
I am thankful that I have a great job. The Cvikota family has been exceedingly generous and intensely loyal to me, and there are very few with whom I would trade places.
I am thankful for my country. It may sound corny in this culture of cool, but I believe this is the greatest country in the world. We are imperfect, prone to discord and political acrimony, and too often apathetic and entitled; yet, we can be a wildly generous and profoundly good people.
I am thankful for a safe place to call home. Our house is over 120 years old, without a truly square corner in the place. The carpet needs replacing and the driveway has cracks. But, we are warm and fed and safe and I can hardly imagine living somewhere else.
I am thankful for you, my clients, readers, and friends.
Now, it's your turn. Happy Thanksgiving!


text:
Austrian Circle
Österreichischer Reichskreis
Imperial Circle of the Holy Roman Empire
Austria Est Imperare Orbi Universo
"It is Austria's destiny to rule the whole world"
The Austrian Circle as at the beginning of the 16th century within the Holy Roman Empire
• Established 1512
• Disestablished 1806
Today part of Austria
This article does not cite any sources. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (July 2015) (Learn how and when to remove this template message)
The Austrian Circle (German: Österreichischer Reichskreis) was an Imperial Circle of the Holy Roman Empire. It was one of the four Imperial Circles created by decree after the 1512 Diet at Cologne, twelve years after the original six Circles were established in the course of the Imperial Reform. It roughly corresponds to present-day Austria (except for Salzburg and Burgenland), Slovenia and the Trentino-Alto Adige/Südtirol region of Northern Italy, but also comprised the Further Austrian territories in the former Swabian stem duchy.
Organisation[edit]
The Austrian Circle was largely coterminous with the "Hereditary Lands" (Erblande) of the Habsburg Monarchy, dominated by the Archduchy of Austria. Beside the Habsburg lands, it included the Prince-Bishoprics of Trent and Brixen, which, however, were largely ruled within the Habsburg lands of Tyrol.
The Circle's territory was again enlarged with the acquisition of the Bavarian Innviertel according to the 1779 Treaty of Teschen, as well as the Electorate of Salzburg and the Berchtesgaden Provostry by the German mediatisation in 1803. Nevertheless, the Austrian Circle was dissolved when Emperor Francis II resigned on 6 August 1806.
Composition[edit]
The circle was made up of the following states:
Type of entity
An der Etsch
Bailiwick Established about 1260, an administrative grouping of lands held by the Teutonic Knights in Tyrol
Archduchy March of Austria established in 976 by Emperor Otto II, raised to duchy by Emperor Frederick I Barbarossa in 1156, to Habsburg in 1278, self-bestowed "Archduchy" since 1358
Bailiwick An administrative grouping of lands held by the Teutonic Order in Austria
Prince-Bishopric Established in 1027 by Emperor Conrad II, Prince-Bishopric since 1179
Duchy Established in 976 by Emperor Otto II, held by the Archdukes of Austria since 1457, part of Inner Austria 1564–1619
Carniola
Duchy March of Carniola established in 1040 by Emperor Henry III, raised to duchy in 1364, held by the Archdukes of Austria since 1457, part of Inner Austria 1564–1619
Prince-Bishopric Established in the 4th century, prince-bishopric since 1170, territory held by the League of God's House since 1367
County Separated from the Patriarchate of Aquileia about 1127, held by the Archdukes of Austria from 1500, part of Inner Austria 1564-1619, merged into Gorizia and Gradisca in 1747
March Established in 1040 by Emperor Henry III, major part to Venice in 1291, remaining territory around Pazin (Mitterburg) to Gorizia, held by the Archdukes of Austria since 1374
Duchy March of Styria established about 970 by Emperor Otto I, raised to a duchy in 1180, held by the Dukes of Austria since 1192, part of Inner Austria 1564-1619
Lordship Held by the Archdukes of Austria since 1464
Prince-Bishopric Established in 1027 by Emperor Conrad II
City Held by the Archdukes of Austria since 1382
County Established about 1140, held by the Archdukes of Austria since 1363, raised to "Princely County" in 1504, to Further Austria 1564-1665
Austrian Circle of the Holy Roman Empire
Habsburg lands
Further Austria (Altdorf
Sundgau (until 1648)
Winnweiler)
Prince-Bishoprics
Teutonic bailiwicks
Circles est. 1500: Bavarian, Swabian, Upper Rhenish, Lower Rhenish–Westphalian, Franconian, (Lower) Saxon
Circles est. 1512: Austrian, Burgundian, Upper Saxon, Electoral Rhenish · Unencircled territories
Circles of the Holy Roman Empire after the Imperial Reform
Franconian
Westphalian (Lower Rhenish-Westphalian)
Lower Saxon
Swabian
Upper Rhenish
Electoral Rhenish
Upper Saxon
Territories of the Holy Roman Empire outside the Imperial Circles
Retrieved from "https://en.wikipedia.org/w/index.php?title=Austrian_Circle&oldid=897608961"
States and territories established in 1512
States and territories disestablished in 1806
Circles of the Holy Roman Empire
1512 establishments in the Holy Roman Empire
Articles lacking sources from July 2015


text:
Q: Sort array by frequency I would like to count how many times is every string in array and sort them by number of times they exist in array
I have this code now
hlasy.sort();

var zaciatok = null;
var pocet = 0;
for (var i = 0; i < hlasy.length; i++) {
    if (hlasy[i] != zaciatok) {
        if (pocet > 0) {
            console.log(zaciatok + ' má ' + pocet + ' hlasov');
        }
        zaciatok = hlasy[i];
        pocet = 1;
    } else {
        pocet++;
    }
}
if (pocet > 0) {
    console.log(zaciatok + ' má ' + pocet + ' Hlasov');
}

it works, but it outputs strings from array sorted by alphabet and no by how many times they are in array.
for example, it outputs
apple - 1
banana - 5
cherry - 4

but I need this
banana - 5
cherry - 4
apple - 1

thanks in advance

A: Two passes. First, compute the number of occurrences of each word:
counter = Object.create(null);
words.forEach(function(word) {
   counter[word] = (counter[word] || 0) + 1;
});

Then, sort the array by comparing two words' counts:
words.sort(function(x, y) {
   return counter[y] - counter[x];
});