Most upcoming artists are disappointed by the fact that they do not have what it takes to attract major labels. Does success come only when you use a popular recording company? Recently, there has been hype about indie artists. This simply means artists who have succeeded even without the assistance of major labels. There are benefits to producing music individually. The most notable gain is the freedom. Most musicians producing under major record companies are not allowed to express their own words and thoughts in their music.
Who are some of the best performing indie artists? Chance the Rapper is just in his early twenties and he is doing wonders in his music career. Most people would have expected him to sign with a major label, after he dropped his mixtape, Acid Rap. On the contrary, he chose to go solo. He went to Los Angeles and joined Social Experiment. Trash Talk is another group, which had made on their own from the very beginning until they signed to Odd Future. In addition there is Lisbon Soul, a popular Italian artist, who have made it on their own. They are using online platforms to reach more audience: Chance the Rapper on Youtube, Trash Talk on Last.fm and Lisbon Soul Jango account.
Dev Hynes have also made success independently. He is known for his Blood Orange project. Although he has produced a few of his albums under Terrible and Domino records, Hynes still makes music with a touch of individuality. This shows you that you do not have to sign with an infamous label to make it in the music scene. As long as you have the talent and you are willing to go an extra mile to promote your music via the cost-effective online platforms, you are bound to succeed. It is time to come out of your closet and become an independent artist. If others are making it, you too can do it.
However, when we talk about music is impossible do not consider the biggest companies in the industry, those which control the majority of music panorama in the world. Once known as the "Big Five", they became "Big Four" and, since November 2011 they are the "Big Three". We are talking about Universal Music Group (about 25,5% market share), Sony Music (about 21,5% market share) and Warner Music Group (about 11,3% market share).
Those three big, also known as "Majors", have always represented the "top" in the world of the music as they always worked to ensure the right diffusion and the right copyright protection of musician creations working under their brand.
With the digital era, which includes not only computers but also portable devices such as MP3 players or the most famous iPod and iPhone, the Majors have always worked to be ready for the change from CD to digital music.
In order to do so, for example, they got agreements with the biggest IT companies in the world to ensure the highest circulation of their own music. One of the latest news in this field is about Google, the famous search engine, and Lyor Cohen, former Warner Music executive. Voices confirmed that between the parts a first agreement about a new music venture has already been reached. The news is taken from Rockol, one of the most complete website about music in all its facets.
Today internet is the main distribution vehicle of music, both new songs and old successes which has been digitalized in the years. That's why is absolutely important, for the biggest three in the music world, not to lose this challenge.
The final "amletic" question is: go indie or go major? What's the best choice?


A rapidly expanding area in construction law involves toxic mold infestation and indoor air quality claims. Remediation costs necessary to eradicate toxic mold often result in claims advanced against the design professional and contractor involved in construction. We are experienced in defending such claims and have counseled our clients as to how best to proceed with resolution when they arise. On these claims we often tap the expertise of attorneys in our Environmental & Toxic Tort Department.
According to the New Jersey Rules of Professional Conduct, "a lawyer shall keep a client reasonably informed about the status of a matter and promptly comply with reasonable requests for information." RPC 1.4(b). Not only is regular communication with the client mandatory, but it is also just good practice.
Joseph A. Petrillo successfully defends the appeal on behalf of his client, an engineering firm, in subrogation case.


text:
Q: Delphi: TJvChangeNotify/TShellChangeNotifier - file's name How to know what file was changed (it's name) on Change Event of TJvChangeNotify (JEDI) or TShellChangeNotifier?
Thanks!

A: Both components use FindFirstChangeNotification to monitor changes. As indicated in its documentation the function does not provide information on what triggered the notification. As such the only possible way to find out what happened using these components is to keep a snapshot of the monitored folder and perform a comparison after a change occurs.
If you decide to use ReadDirectoryChangesW as suggested by FindFirstChangeNotification's documentation, see this answer. Or instead, if you decide to use SHChangeNotifyRegister see this article.

redpajama_set_name: RedPajamaStackExchange


Just a 90's kid spending my life working from my bedroom on Insignia, a 16-bit Metroidvania. I left my old UX design job for in 2017. Games are my thing, and I'm laser focused on continually improving my skills, process and sensibilities to make this one as awe-inspiring as possible. I have the talent and drive to produce Insignia on my own, but I can't release it without you.
The game cannot exist without a community behind it. That's all there is to it. If I can't secure a path to funding, development ceases. Funding right now just means covering cost of living for the development team, meaning me.
Besides the game, I produce a lot of supplementary content shared on twitch, tumblr and reddit documenting my process for people who want to follow and learn with me. If you take a look and find that it interests you, I'd be happy to have you as one of my patrons.
There are a lot of games in development that are on Patreon, why should I support yours?
Because more than anything, I want to carry the torch for a kind of design ethos that I'm inspired by. I want to produce the same wonder and imagination I felt growing up with Disney, Studio Ghibli, Square or Nintendo and use it to deliver a story that feels contemporary and personal.
I want the world to have more games like that in it, and I'll dedicate my life to making sure it does if you believe in me.
Kind strangers and scholars of the pixel art.
If we reach $100 a month, I'll be able to afford better internet access for longer, more frequent and higher quality twitch streams.


Abortion is the early ending of a pregnancy. It uses medicine or surgery to remove the embryo or fetus and placenta from the uterus. The procedure is done by a licensed health care professional.
It is a personal problem, depending on your choice. It can be managed by reducing your risk factors. Please discuss with your doctor for further information.
The common symptoms of abortion are bleeding, period-type pain or discomfort. You might experience some bleeding and period-type pains for up to 14 days after any type of abortion.
Abdominal pain that doesn't improve after taking painkillers.
This is a decision of a woman who is pregnant for an unwanted pregnancy or birth defects prevention.
What increases my risk for abortion?
How to diagnose pregnancy before the abortion?
Your doctor will ask about your medical history and will do a physical exam. You will have lab tests to make sure that you are pregnant. You may also have an ultrasound to determine how old is your baby.
It will depend on how many weeks pregnant you are.
Medical abortion, such as misoprostol, mifepristone, methotrexate.
Surgical abortion, such as vacuum aspiration or dilation and evacuation (D&E).
After 9 weeks, surgical abortion is usually the only option.
What are some lifestyle changes or home remedies that can help me manage abortion?
Having a certain pregnant plan.
Abortion – Topic overview. http://www.webmd.com/women/tc/abortion-topic-overview#2 . Accessed September 16, 2016.
Abortion. https://medlineplus.gov/abortion.html . Accessed September 16, 2016.
Abortion – what happen. http://www.nhs.uk/Livewell/Sexualhealth/Pages/Abortionwhattoexpect.aspx . Accessed September 16, 2016.
Abortion – reasons women choose abortion. http://www.webmd.com/women/tc/abortion-reasons-women-choose-abortion. Accessed September 16, 2016.


text:
Former UN chief concerned over monsoon floods in Rohingya camps
Former UN secretary general Ban Ki-moon expressed concern that monsoon floods could threaten the lives of Rohingya refugees in sprawling camps in Bangladesh. ...
Ex-UN chief concerned over monsoon floods in Rohingya camps
KUTUPALONG, Bangladesh (AP) — Former U.N. Secretary-General Ban Ki-moon has expressed concern over risks of monsoon floods threatening the lives of Rohingya refugees in...
San Francisco Chronicle 2019-07-11

redpajama_set_name: RedPajamaCommonCrawl


I find it simplest to note when the car in front passes a fixed object and count one elephant, two elephant, three elephant.
We were taught (in the US), "One car-length per 10 MPH" as in if you're going 50 MPH then leave 5 car lengths distance between your car and the one in front.
The traffic law in Germany stipulates a reaction time of 1 second.
For people not familiar with the German guidelines, you take your speed in km/h, divide by two, and that gives you your "safe" distance in metres.
Incidentally, the UK has a 2 second guideline for the same purpose. And they used to have a snappy slogan: "Only a fool breaks the 2-second rule". One advantage of this over the "halber Tacho" rule is that it is easier to apply in practice.
Next message: Les Chambers: "Re: [SystemSafety] Small but useful Detail on Road Stopping Distances"
Previous message: Mike Ellims: "Re: [SystemSafety] Small but useful Detail on Road Stopping Distances"
Maybe in reply to: Peter Bernard Ladkin: "[SystemSafety] Small but useful Detail on Road Stopping Distances"


This is THE big fish that should be on every hotelier's mind. We all know that Facebook is important and that your status is first and foremost measured by your numbers of fans, but what does this number really mean? Is having 10,000 fans versus just 2,000 directly correlated to the fiscal amount of business you do?
Fans range from people who have liked your page once to those who check in from time to time or visit multiple times a week. Frequencies aside, how do you gauge which of your fans are spreading the good word? Are they consistently recommending your hotel to their friends? Are they going out of their way to help grow your business? I don't mean to discount a large fan base, not in the least. Brand awareness is the first move toward sales, but there are still many steps in-between.
Instead of fans, what you really need are influencers – people who will actually bring guests to your hotel. Well, you're in luck! Where Facebook really shines is that it is possibly the best online route for nurturing your fans and turning them into influencers. Think of the website as an incubator; every fan has the potential to sing your praises, but you have to take full advantage of Facebook's capabilities to woo them over.
I'm a big believer that word-of-mouth hotel recommendations from friend to friend are still one of the most effective ways to get new customers. I'm old school like that, but that doesn't mean I don't embrace the voracious power of social media. Turning fans into influencers is like converting word-of-mouse back into word-of-mouth.
In the past, I've talked about how to effectively use new content on your Facebook page to generate more likes and more fans. (If you missed this article, view it on my blog at www.lma.ca) This foot-in-the-door is the easy part, and I'll assume that you're clear on it. If not, there are a multitude of articles and resources at your disposal on the web. What I'm talking about now is the next step.
Fans won't turn overnight. You will have to go out your way on a one-to-one basis for them to return the favor. These types of connections take time; your fans won't all make themselves readily available at the drop of a hat. Think of the fun photos or interesting factoids you post as building blocks, each one a part of a bigger picture. The more you build, the more your influencers will emerge.
"But I monitor my page's insights," you may be thinking to yourself. True, this is beneficial and something I'd definitely advocate. But it won't tell you which of your fans are repeatedly liking or commenting, or even more importantly, which of your fans are taking your message home. So, you have two options. Make a list of all the people who respond to each post and tally it up, or, trust the process and treat your page's fans like you would your guests.
There's a third option that I have to touch on briefly; software developments. The technological powers that be are swiftly catching up, and finding your online influencers is only going to get easier. Check out the work of companies like Klout.com. Give it a year or two and their class of web-based applications will be a staple for professional Facebook pages. Even with an electronic panacea like this, however, it'll still be hard to gauge word-of-mouth. That's why I insist: trust the process.
Compliment fans who post supportive comments. Answer questions fully and promptly. Address concerns with an honest explanation. And do so on a one-to-one basis. The buzz term for this is "Online Concierge," which I had no part in designating but still love to throw around. As an online concierge, it's your job to be thoroughly knowledgeable about your property and the surrounding region and be able to guide your fans with their inquiries.
When you help someone online, not only will they remember it, but others will also see you helping that person. If you can impress a fan with the substance of your answers, then they will impress you by casually talking about your hotel to their friends. A resourceful and courteous online reputation is a passive form of promotion in its own right.
On the flip side, are you willing to accept constructive criticism? Have you set up your Facebook page so there's a forum for fans to make suggestions? People love to be heard and be involved at the planning stage. Plus, you never know, there might be a gem or two out there to make it all worthwhile.
Programmers at Facebook and third-party operators have done a wonderful job ensuring that the site is compatible with a host of extensions and custom-coded apps. Fans have adapted to expect these catchy additions, and fan pages have in turn adapted to their expectations. All this means there's a growing propensity to use the website as a one-stop shop.
Analyze your competitive set. What tabs or fun little accessories have they added to customize their page? What can you emulate? Start by adding tabs that integrate all your other social media. Code for a reservation system or a newsletter signup tab. Any opportunity you have to engage more users with a fully-loaded page is one you should take.
Then the plan is to exceed their expectations. They should be proud to be your fans. Organize your photo albums and consistently add great content. Coupons, offers or Facebook-specific programs work well, too. Every upgrade you make will appeal to a slightly different subset of people within your gross fan base. Some people want candid photos of scenic beaches, others are looking for deals. Make your page exclusive by being inclusive.
This ties into the idea of being an online concierge as well as becoming a hub. Your posts don't always have to be about you. In fact, they shouldn't. Talk about that adorable small business a few blocks away from your property. Emphasize your commitment to sustainability. Share all local events. Publicly thank a generous supporter. Start to think of your fans as a part of your team, then lead them accordingly.
And remember, your page isn't just for you. It's a place for fans to connect with one another, not just with your hotel. There are some amazing stories out there of friends finding each other on Facebook through mutual interests, then they turn out to be neighbors in real life. And they'll remember who played matchmaker. You have the opportunity to brighten the lives of others, even if only for a couple seconds each day. Be sure to keep this mindset whenever you log on.


text:
Coronavirus's impacts on NBA Draft, local college players
Karthik Venkataraman chats with CBS Sports reporter Jon Rothstein about how players like Gonzaga forward Killian Tillie are affected.
Author: Karthik Venkataraman
The NBA Draft is still scheduled for June 25 despite the coronavirus pandemic.
That could change though depending on the coming months. The NBA Draft process has already seen changes, which affects at least one player from our area; former Gonzaga forward Killian Tillie, who just finished his senior season.
It all started with the cancellation of the NCAA Tournament. CBS Sports reporter Jon Rothstein said not having an NCAA Tournament affects the French big man's draft stock.
"Killian Tillie was somebody that could have shined during the NCAA Tournament and all of a sudden he could have become much more of a commodity in terms of shining at the next level," he said.
Rothstein gave examples of former players around the nation, like Syracuse's Malachi Richardson and Villanova's Donte DiVincenzo, as players who turned themselves from second round to first round NBA Draft picks by playing really well in the NCAA Tournament.
Tillie didn't get that chance this year.
Without it, the second round seems more likely for him due to recurring injuries stopping him from reaching his full potential.
Rothstein said it also doesn't benefit guys like Tillie because of how different the draft process is going to be, which could very well mean Tillie doesn't get a chance to impress on the court again before draft night.
"The majority of what I've gathered is that NBA personnel are planning to not have a combine, to not have pre-draft workouts," he said. "They are preparing to make their decisions on Skype interviews and prior scouting."
Rothstein said this also affects others guys on Gonzaga's roster who could declare fore the draft, like Filip Petrusev and Corey Kispert, but are also projected to be drafted in the second round if they do.
"If you don't have a prognosis or guarantee that you're going to be a first round draft pick, I don't think it makes a lot of sense to put yourself in a position to put yourself in the NBA Draft," Rothstein said. "I think you have to be judicious and diligent in your decision making always, but even more so now because you can't audition for anybody."
Rothstein also gave his thoughts on Washington State star CJ Elleby.
He doesn't doubt Elleby will be an NBA-caliber player, but once again due to the uncertainty and not getting to show NBA scouts what he can do in a combine like setting, Rothstein believes Elleby will return to school as well.
RELATED: Gonzaga track athlete starts virtual 5k race for charity
RELATED: Rui Hachimura plays in NBA 2K20 Tournament, Killian Tillie is his water boy
RELATED: 'The most ugly, beautiful shot': An oral history of Casey Calvary's tip in


text:
Published on 13.12.2018 | by Päivi Stenroos |
Business development Smart Tampere
The AI Hub Tampere is based on the needs of local companies. Many of them are interested in utilizing AI and consulting firms are eager to offer their advice. However, those companies may not be quite sure about the first steps they should take or about how to proceed in practice.
AI Hub Tampere helps companies to understand both the potential and the limitations of AI, giving them a better basis to start buying AI that serves them well.
– The university already cooperates with larger companies, so we need to focus on small and medium-sized ones. We want to make AI accessible for everyone, explains Heikki Huttunen, the founder of AI Hub Tampere and Associate Professor at Tampere University of Technology (TUT).
AI Hub Tampere is swiftly starting its activities, and there are several events coming up in December. SMEs interested in AI will be provided with helpdesk services, workshops and experimental piloting. The guidance is publicly funded and thus free of charge and neutral.
– We are targeting engineers who work in the local companies and know their grassroots-level needs, and also managers who make the AI outsourcing decisions, Huttunen says.
– The best thing about AI Hub Tampere is the fact that it makes the expertise and enthusiasm of TUT professors and students available for any company. We really hope that companies will find and use this opportunity, says Senior Business Advisor of Smart Tampere program, AI and analytics theme Niina Siipola from Business Tampere.
AI Hub Tampere brings together companies and academia, but it also aims to boost collaboration between companies. This will happen for example in workshops where engineers from different companies work together on challenges related to AI, and strenghten the whole AI ecosystem at the same time.
AI Hub Tampere focuses on the thematic area of intelligent machines, but it welcomes companies of any field to use its services. The theme was chosen because intelligent machines is one of the industries in the Tampere Region that is significant in the export business. Keeping up-to-date with AI and robotics gives those companies the competitive egde.
To boost the competitiveness of the region AI Hub Tampere is among the first ones to join the nationwide AI Hub network that is being established. The hub is an important part of the AI and analytics theme of Smart Tampere program and helps achieve the strategical and industrial policy objectives of the City of Tampere.
– Further to that, AI Hub Tampere can be a concrete asset in the invest-in work, making the region known for its AI expertise in a similar way that Tampere Imaging Ecosystem already does in its field, says Siipola.
AI Hub Tampere is funded by The Regional Council of Pirkanmaa, TUT (the new Tampere University from 2019 onwards), Smart Tampere program of the City of Tampere and Forum for Intelligent Machines FIMA. The hub is cooperating with the RoboCoast project in Pori and an AI Hub of University of Eastern Finland. DIMECC is also involved in the AI Hub's network, and Business Finland has supported the project from the very beginning.
—> tampere.ai
Smart Tampere is a strategic program of the City of Tampere implemented by Business Tampere and the City.
AI Hub
Smart Tampere
Agile experiments help create useful urban services
The Smart Tampere program is boosting smart city development with agile experiments, where companies can test their services or products using the city as a test bed and a living lab. Around twenty experiment projects arose in 2018.


Vigna may be grown from seed sown early indoors and transplanted outside after frost, or sown directly in the garden in summer, or planted as a potted plant.
Nick the seed gently and soak overnight to aid germination.
Sow vigna indoors 6-8 weeks before the last frost.
Sow ½ inch deep in seed-starting formula.
Direct sow in well-drained, ordinary soil in full sun after danger of frost. Choose a location with a support on which the vines may climb.
Sow seeds evenly and thinly in rows 18 inches apart and cover with ½ inch of fine soil.
Seedlings will emerge in 7-21 days depending on soil and weather conditions.
Thin to stand 8-10 inches apart when seedlings are 1-2 inches tall.
Select a location in full sun with good rich moist organic, well-drained soil, and a support in which the vines will climb.
Vines can reach 10 feet; be sure to provide supports.
Flowers are fragrant and good for cutting.
Plants are perennial in warmer areas.
Anthracnose: This is a fungus disease that causes circular spots on foliage that are slightly sunken. The spots enlarge and turn black. Extended periods of heat and humidity facilitate anthracnose growth. The fungus overwinters in diseased plant debris. Burpee Recommends: Provide sufficient space between plants for good air circulation, avoid overhead watering which can spread the fungus spores, keep a clean garden, remove and discard all diseased plant material and rotate crops. Use a mulch to prevent spores from splashing from the soil onto plants.
Blight: This causes brown concentric rings to appear on the lower leaves. The spots coalesce; the leaf turns brown and may drop off the stem. Leaf drop moves up the stem. This fungus overwinters in plant debris and weeds. Greasy, greenish-black, water soaked spots appear on the lower leaves. The spots enlarge and if the weather is wet they will look mildewed. Fruits develop dark rough spots. Rainy or cloudy days with temperatures of 70-80 degrees F and nights at 40- 60 degrees F provide ideal conditions for the rapid growth of this fungus. It is retarded by hot dry weather. The fungus is air-borne and can spread from diseased plants growing nearby. Burpee Recommends: Practice good garden hygiene at the end of the season and discard, do not compost, possibly diseased plants. Space plants to allow for adequate air circulation. Avoid overhead watering which may spread fungus spores.
Cercospora Leaf Blight: Small flecks develop a yellowish halo appear on the leaves and turn brown and coalesce. They cause the leaves to wither and die. Burpee Recommends: Remove infected plants and destroy all plant debris. Rotate crops.
Can I grow vigna in a container? No, the vines are just too large.
Are vigna flowers good for cutting? Yes they make great cut flowers, and are fragrant too.
Why do I see ants on my vigna flowers? Vignas are pollinated by ants so it is normal to see them on the flowers. If they are on the plants and they are not in bloom, you may have aphids, which attract ants.
Is vigna a perennial? Plants are tender perennials and will survive outdoors in zone 10.
Why hasn't my vigna bloomed? These tend to bloom fairly late in the summer, if could just be too early. Otherwise it may be in too much shade, or have too much nitrogen in the soul from fertilization.


NO CSF serum ratio and index are suggestive of local production in the CNS as well as passage through the disturbed blood brain barrier. Some authors suggested that the increased level of CSF NO in patients with bacterial meningitis is due to blood CSF bar riers dysfunction or disturbed permeability as a result of the inflammatory process. Bacteria are thought Zotarolimus(ABT-578)? to enter the CNS either by local tissue damage or by transcy tosis through microvascular endothelial cells. And, as host defense mechanisms are limited in the CSF, bacte ria can multiply and reach titers of up to hundred col ony forming units per milliliter. In response to bacterial cell wall components released by autolysis, the rapid increase of proinflammatory cytokines and chemok ines is followed by the appearance of granulocytes and this resulted in enhanced blood brain barrier permeability.
It has been suggested that NO related compounds, most probably ONOO released from infiltrating inflammatory and endothelial cells, may cause loss of integrity of the blood Inhibitors,Modulators,Libraries CSF barriers. Other studies reported no destruction in blood CSF barriers with meningitis and claimed increased CSF NO to local pro duction during the course of the inflammatory process which is mediated by cytokines. Marra et al. found infection of the brain without detectable bactere mia in a pneumococcal respiratory tract infection model indicating that pneumococci are able to disseminate by a non hematogenous route. In contrast, some studies did not find changes in the CSF NO with bacterial meningi tis.
A possible explanation for this discrepancy would be a difference in the study subjects and severity of the dis ease. A positive correlation was found between NO index and CSF WBCs. Another interesting result in this study is that the serum NO level was higher in patients with gram pos itive CSF culture compared to negative culture indicating Inhibitors,Modulators,Libraries that the NO production is Inhibitors,Modulators,Libraries related to the presence of the organisms. Previous reports indicated that higher levels of NO are associated with severe disease. CSF pleocyto sis, protein concentration, granulocyte percentage, high tumor Inhibitors,Modulators,Libraries necrosis factor alpha, low glucose and L arginine during the initial stage of meningitis. It has been suggested that beside the bacteria itself, neu trophil accumulation in the subarachnoid space is a hall mark of the acute inflammatory response in bacterial meningitis.
Activated neutrophils can secrete large amounts of ROS and a wide variety of potential triggers as cytokines, complement factors and platelet activating fac tor in the CSF of patients Inhibitors,Modulators,Libraries with meningitis. Other possible cell types involved in ROS generation comprise microglia macrophages, cerebral endothelial useful site cells, astro cytes, and neuronal cells. In this study, serum LPO levels were elevated in patients with meningitis which points to the presence of a general status of oxidative stress affecting cellular membranes.
Pathway analysis of the joint mRNA and miRNA results provided the first in vivo evidence of significant involve ment of axon guidance pathway and its downstream sig nalling pathways on both transcriptional level and regulation level. Axon guidance Perifosine clinical pledges precise path finding and defines their termination zones and synaptic Inhibitors,Modulators,Libraries partners, which is fundamental to neuronal devel opment and networks. In addition, misrouted fibers have been shown in AD and PDs brains. Furthermore, it is well known that HIV envelope glycoprotein can cause axonal degeneration and recently axon damage has been claimed as a key predictor of outcome in mul tiple neurological disorders, including HAD. Axon guidance pathway contains four prominent families of ligands, their receptors Inhibitors,Modulators,Libraries and downstream signalling proteins.
The role of axon guidance pathway molecules Inhibitors,Modulators,Libraries in the maintenance and plasticity of neural circuits has been reported. More over, the variations in axon guidance pathway genes have been reported to pre dict PD outcomes. Significantly, 9 of our DE miRNAs have been found targeting this pathway according to Tar getScan results, and more importantly these results sup port previous observations with 3 out of 4 ligands receptors being dysregulated in our mRNA studies, in cluding ephrin receptor A4, netrin G2, and semaphoring 3A, strongly sug gesting the impairment of axon guidance pathway in HAD brains in vivo. Moreover, our results highlight axon guidance down stream signalling pathways, which allow precise patterns of connectivity within the CNS.
For instance, the MAPK pathway comes out significant in both our mRNA and miRNA profiling. Studies have shown that the activation of MAPK is necessary for axon guidance, and it con tributes to netrin signalling Inhibitors,Modulators,Libraries in axon guidance. Besides, netrin dependent axon outgrowth and orientation can be antagonized by inhibition of ERK 1 2. The role of MAPK pathway in HIV infection has also been well docu mented. For instance, it has been reported that the MAPK pathway plays a crucial role in HIV 1 replication and viru lence and is one of the transcriptional signatures in HIV long term non progressors. In addition, the binding of HIV 1 GP120 to CD4 receptors on T cells can activate the MAPK pathway and induce transcription of cytokine and chemokine genes. Interestingly, MAPK pathway was targeted by 3 DE miRNAs and it includes 11 of our DE genes, such as RPS6KA1, FLNA, RRAS2, and MAP2K4 etc.
each of which play an important role in MAPK signalling. MAPK signalling cross talks with the Jak STAT signalling pathway at multiple levels. In mam mals, the Jak Inhibitors,Modulators,Libraries STAT signalling pathway is the principal sig nalling mechanism for cytokines and growth factors useful site and therefore plays a key role in cell proliferation, differenti ation, cell migration and apoptosis.
As there is a high degree of similarity between the populations from a treatment, reads from each population from a treatment were used as biological towards replicates in testing for differen tial expression. Identification of genes responding to water stress conditions To identify genes responding to stress treatment, sam ples from control and stress treatments taken at the end of the stress treatment were analysed for dif ferential gene expression. Analysis of differential gene expression revealed a total of 5270 transcripts that were significantly differen tially expressed between the control and stress treatments. Read counts from the three libraries within each treatment are very similar. A heatmap of gene expression of the top 200 genes is shown in Figure 3.
Variance stabilized data obtained with DESeq pacckage was used to generate the heatmap. The gene expression patterns between the treatments are distinct while within each treatment they are similar. Gene identities of the most differentially expressed transcripts are shown in Table 3. Several heat Inhibitors,Modulators,Libraries shock proteins, cell wall genes such as expansins and drought stress related transcription factors are among the most strongly differen tially expressed genes. Gene Ontology enrichment analysis In order to determine the biological function of differen tially expressed genes between control and stress treatments, gene ontology based enrichment tests were performed. The top most significantly differ entially expressed genes were tested for enrichment using a web based Inhibitors,Modulators,Libraries tool. Arabidopsis homologs of the predicted gene models were obtained by BLAST searches.
A total of 175 gene categories were found to be significantly enriched among the genes that were differentially expressed be tween control and stress treatments. Of these, 140 categories were down regulated, while 35 categories were up regulated under stress treatment. Inhibitors,Modulators,Libraries Within the categories that were up regulated, most of them were involved in stress response. For example, four of the most significantly enriched gene categories are response to chemical, temperature, heat and abiotic stress stimu lus. Similarly most of the down regulated genes belonged to gene categories involved in metabolic pro cesses and cell wall organisation.
Identification of growth related genes To Inhibitors,Modulators,Libraries identify genes relating to growth and development we compared the gene expression between five plants from each population sampled at the beginning of Inhibitors,Modulators,Libraries the treatment and the same five plants sampled at the end of the treatment. Gene expression analysis revealed a total of 3582 genes with significant differential expression between C0 and C1 samples. To study the expression patterns of these genes under stress conditions we compared the expression of significant genes from this analysis with those showing significant differential expression selleck chem Volasertib between control and stress treatments.
All of these miRNAs, except for miR827, were members of 21 families that are conserved in diverse plant species. The abundance of miR NAs varied greatly. MiRNA families highly conserved across plant species, such as miR166, miR167, and miR168, were sequenced more than 10,000 times, whereas previously known stress induced members, such as miR395 and miR399, were detected less kinase inhibitor Enzalutamide than 10 times, indicating that tissue specific expres sion patterns of miRNAs are related to their functions. In contrast, most rice or monocot specific miRNAs were detected with low read numbers, except for miR444 and miR528, which were represented by 3,917 and 6,305 cop ies, respectively. There were significant variations in expression levels for members of the same family. For example, the abun dance of the miR159 family varied from 9 to 7,113 reads.
Most novel miRNAs showed weak expression levels. The reads for their miRNA s were even lower. All of these newly identified miRNAs appeared to be rice specific and had not Inhibitors,Modulators,Libraries been reported in other species. Most novel miRNAs were not detectable Inhibitors,Modulators,Libraries by northern blotting, except Can miR 10, but all were confirmed by using Baricitinib buy more sensitive array analysis. Surprisingly, novel miRNAs discovered in previous deep sequencing of rice grain small RNAs were rarely present in our dataset.
The performance of the models decreases only slightly when 40 60% of the whole dataset is used for the model building, and the models are still predictive when as few as 10% of all kinase inhibitor combinations or when 10% of all kinases are present in the dataset. Moreover, the small margins http://www.selleckchem.com/products/Imatinib-Mesylate.html between the P2 and P2kin parameters indicate that the reliability of predictions for new unassayed kinases does not differ much from the reliability of predictions for the kinases for which some interaction data have been already assayed and used in the modelling. Comparisons of the results for the three data analysis methods also indicate that their perfor mance is more similar for larger datasets. For sparsely populated datasets the performance of k NN method deteriorates faster than for the SVM and PLS methods.
Predicting interacting versus non interacting kinase inhibitor pairs Although all models predict interaction activities on a continuous scale, they can also be used Inhibitors,Modulators,Libraries to predict whether new inhibitors and kinases interact or not. In the quantitative modelling we assigned the value pKd 4 to all inhibitor kinase combinations that had been found not to interact in the primary screen the screen for which the detection limit was pKd 5. Hence if the activ ity predicted for an inhibitor kinase pair falls below a pre specified threshold level, the pair could be classified as non interacting, while if it falls above this threshold it could be classified as interacting.
The selection of the threshold value will affect the sensitivity and specificity of the classification, which can be defined Inhibitors,Modulators,Libraries as A common measure for the classification quality is the Receiver Operating Characteristic curve, which is plotted as sensitivity versus one minus specificity upon varying the discrimination threshold value. The area under the ROC curve is a measure of the discrimi natory power of a classifier, which is insensitive to class distributions and the costs of misclassifications. AUC 1 indicates perfect classification, while AUC 0. 5 means that the classifier Inhibitors,Modulators,Libraries does not perform better then random guessing. Figure 4 compares ROC curves for the k NN, SVM, and PLS models, built on the largest and on the smallest sets of kinases as described in the previous section. Inspection of Figure 4 shows, for instance, that at a sensitivity Inhibitors,Modulators,Libraries of 0. 80 the SVM model build on the largest set of kinases has a specificity of 0. 92. In other words, using a threshold that identifies 80% of truly active kinase inhibitor pairs as being active, the number of false positives amounts to only 8%. The Inhibitors,Modulators,Libraries performance of the PLS and k NN models were slightly worse, at the sensitivity of then 0. 80 the false positives amount to 11 and 13%, respectively.
These data suggest that PKC a but not cell assay PKC b acts as an upstream regulator of p115RhoGEF phosphorylation in TNF a challenge. Role of the PKC ap115RhoGEFRhoA pathway in TNF a induced F actin rearrangement and BMEC barrier dysfunction Inhibitors,Modulators,Libraries We analyzed the effect of RhoA inactivation, P115Rho GEF and PKC a knockdown on TNF a induced F actin dynamics by immunofluorescence and bar rier permeability by TER. Before stimulation, Bend. 3 cells did not display stress fibers although they exhibited an extensive cortical actin Inhibitors,Modulators,Libraries network. After 3 h of TNF a exposure, cells exhibited pro minent stress fiber formation and paracellular gaps. However, the stress fiber formation and intra cellular gaps induced by TNF a were reduced by inhibiting the activation of RhoA, p115RhoGEF and PKC a.
Furthermore, as shown from Figure 5 B, after expo sure to TNF a for 12 h, the TER of cells with p115Rho GEF depletion Inhibitors,Modulators,Libraries and PKC a displayed as 67. 82. 49 and 60. 53. 64cm2, higher than that of vector 2 cells. This indicates inhibition of RhoA activation, and suggests that depletion of p115RhoGEF and PKC a could alleviate TNF a induced barrier breakdown. Moreover, according to our data, the inhibitor of p115RhoGEF acted more Inhibitors,Modulators,Libraries efficiently than the inhibitor of PKC a in repairing the TER. Discussion BMECs, which are linked by tight junctions, act as a physical and metabolic barrier to shield the brain from toxic substances in the blood, supply brain tissues with nutrients, and filter harmful compounds from the brain back into the bloodstream. However, the normal physiological functions of the endothelium are perturbed during serious sepsis.
It has been shown that TNF a contributes to endothelial barrier breakdown and cytokine transport across the blood brain barrier in sepsis. Direct i. v. injection of recombinant TNF a also can induce BBB opening. Therefore, identification of the inflammatory signaling Inhibitors,Modulators,Libraries initiated by TNF a in BMECs is paramount to understanding the mechanisms of infectious brain edema. RhoA is a key regulator of cytoskeletal dynamics, actin stress fiber formation, and myosin phosphorylation, and thus by inference, in the control of endothelial barrier function. However, the involvement of RhoA sig naling has recently been challenged. Opposing studies have indicated that Y 27632 does not counteract either histamine induced microvascular leakage in the airway or an LPS induced increase in permeability of skele tal muscle. It is possible that different cell types and different stimuli regulate different signal transduction pathways for altering endothelial cell permeability. In our study, TNF a induces a robust activation of RhoA from 1 min up to 12 h. The TER of Bend. 3 and vector 1 with TNF a decreased at 30 min, selleck chemicals Bosutinib and dropped to the lowest level at 12 h.
27% and 68. 44%. Although mortality tests were not conducted against deltamethrin due to the limited number of field mosquitoes collected, low mortalities would be expected based on the http://www.selleckchem.com/products/epz-5676.html high RR50 values for this insecticide. Effectiveness of synergists No significant increase in mortality rate was detected in most populations after synergist treatment. The exceptions are those from Ang Mo Kio, Clementi, and Pasir Ris, which showed significantly higher mortalities after the addition of DEF to cypermethrin and permethrin, and those from Woodlands, showing a significant four fold increase in mortality Inhibitors,Modulators,Libraries when DEF was added in etofenprox. However, despite the statistical significance in the enhancement, the synergist did not recover the toxicity of the pyrethroids, with only 3 data points marginally exceeding 50% mean mortality.
DEF treatment to all pyrethroid assays led to a slight, but not significant increase in the mortality of Ae. aegypti adults in most strains. Counter productively, in many populations, the synergist antagonised the toxicity of pyrethroids. Most marked is TPP which reduced the mortality rate rendered by all insecticides. Inhibitors,Modulators,Libraries Reduction of mortality caused by cypermethrin was as low as 42 fold, permethrin as low as 23 fold and etofenprox as low as 14 fold. Treatment with any of the three synergists did not increase the mortality of all Ae. aegypti strains to pirimiphos methyl. In summary, the synergists are not effective in enhancing the toxicity of insecticides against local Ae. aegypti.
Biochemical assays On average, adults from all locations except Woodlands showed a very low frequency of altered AchE activity based on the expected 30% propoxur inhibition of AchE activity in susceptible individuals. However, individual Ae. aegypti from all locations except Woodlands, exhibited significantly increased altered AchE activity. There was no evidence of elevated Inhibitors,Modulators,Libraries EST activity in any of the populations tested. The population from Clementi was the only one with elevated GST level. The populations from Yishun, Woodlands Inhibitors,Modulators,Libraries and Jurong Inhibitors,Modulators,Libraries East exhibited significant increase in mean MFO levels, but the increase in MFO activity was only detected at low frequency at the individual level in Jurong East population. Discussion Susceptibility status Aedes aegypti populations in Singapore view more have previously been reported to be resistant to permethrin, and a study in 1999 showed that the RR50 of field Ae. aegypti against permethrin was 12. 9 fold of susceptible strain. A study from 2004 2007 has also shown resistance of Ae. aegypti to cypermethrin. More recently, we reported the resistance of Singapore Ae. aegypti larvae, to a panel of pyrethroids. Detection of resistance among Ae. aegypti adult is thus of no surprise.
in a phase II study of sunitinib in HCC, and suggest that inhibition of KIT signal ing may contribute to sunitinib antitumor activity. The lack of early separation in the sKIT TTP and OS Kaplan Meier curves suggests that two www.selleckchem.com/products/Temsirolimus.html subsets of patients with a low sKIT ratio might exist one that has markedly prolonged TTP and OS, and another subset with no difference. How ever, the relatively Inhibitors,Modulators,Libraries small sample size and higher level of censoring in the low sKIT group should be taken into consideration. In the study by Zhu et al, patients with HCC were treated with sunitinib at a dose of 37. 5 mg day on Schedule 4 2. The pharmacodynamics of VEGF A, sVEGFR 2, and sVEGFR 3 were similar to those seen in the present analysis, but levels of sKIT and VEGF C did not change significantly from baseline over 4 cycles of sunitinib treatment, in contrast to the present findings.
Inhibitors,Modulators,Libraries Nonetheless, delayed tumor progression was associated with an early decrease in circulating sKIT, con sistent with the findings presented here. The possible role of KIT in HCC Inhibitors,Modulators,Libraries is unclear. A retrospective study of archival tumor specimens from patients with Inhibitors,Modulators,Libraries histologically confirmed HCC suggested that KIT is not significantly overexpressed in this tumor type. However, KIT blockade by imatinib mesylate inhibited HCC development in mice with chronic liver injury, via antiproliferative effects on KIT expressing liver progeni tor cells. A number of limitations apply to the biomarker inves tigation reported here. Statistical analyses were not strongly powered, with plasma samples from 37 patients at baseline and declining sample sizes over time due to treatment discontinuations.
Analysis of plasma proteins in relation to objective response was further limited by the proportion of patients not evaluable by RECIST. As this was a single arm sunitinib study, it was not possible to determine whether biomarker associa tions with clinical Inhibitors,Modulators,Libraries outcome were predictive or prognos tic in nature. Thus, high plasma VEGF C at baseline may represent a predictive factor for patients with HCC treated with sunitinib, consistent with potent inhibition of VEGFR 2 and 3 by this tyro sine kinase inhibitor. Alternatively, plasma VEGF C may represent a positive prognostic factor in HCC, indepen dent of treatment modality, as has been shown for the absence of cirrhosis in some HCC studies. However, there are data to support high tumor VEGF C expression Dasatinib molecular weight as a negative prognostic factor, independent of other variables, in non small cell lung cancer, esophageal cancer, and gastric cancer, while high plasma levels of VEGF C served as an independent negative prognostic factor in colorectal cancer.
January and February were excluded for randomization because Chinese traditional especially spring festival is always in these two months and there are much fewer inpatients during the time period. In order to avoid selection bias, an enrolment scheme was adopted using alternating prespecified month of inpatient admission from year to year. Inhibitors,Modulators,Libraries For example, in the first year of data collection, pathology confirmed pri mary breast cancer patients admitted to inpatient treat ment in March would be enrolled into the study. in the second year, inpatients admitted in April would be enrolled. All cases within the selected month were reviewed and patients information was collected based on the designed case report form. In each selected month, if inpatients admissions were less than 50 in that year, more cases from the neighbouring months were reviewed until the total number in that year reaches 50.
Whereas, if inpatients number in the selected month exceeded 50, all cases should be reviewed. To ensure that the national study was geographically representative, it was designed to include patients enrolled at sites from all 7 traditional regions Inhibitors,Modulators,Libraries across China. All patients enrolled in this study must meet 3 key inclusion criteria pathology confirmed primary breast cancer inpatient admission date was within the selected month in the study hospital and received or receiving treatment for breast cancer. This study was approved by the Cancer Foundation of China Institutional Review Board. Patient consent was not required for this study because there were no antici pated risks for the participants of the study.
The data was stripped of any patient identifiers per the approved pro cedures. De identified data were maintained on secure database. Only research team members have access to the data. All data will be reported in aggregate. Pathologic Diagnostic Criteria Histological subtype was based on Inhibitors,Modulators,Libraries the 1981 and 2003 Inhibitors,Modulators,Libraries WHO histological classification criteria. Staging of breast cancer was done according to the AJCC TNM staging system of year 1997 and after. Data Collection and Quality Control The following data were systematically collected for all enrolled patients via medical chart review general information including date of diagnosis, visits to other health care professionals, inpatient admission date, diag nosis at admission, inpatient discharge date, and dis charge Inhibitors,Modulators,Libraries outcome. demographic characteristics at the time of diagnosis admissions including age, occupation, height, weight, Paclitaxel microtubule education and marital status. breast cancer risk factors such as age at menarche, age at menopause, age at marriage, age at first delivery, num ber of live birth, breastfeeding history, family history of breast cancer, use of oral contraception, history of smoking and alcohol drinking.
When using PLS we created both linear and non linear models. in the latter case the dataset included cross terms derived from kinase and inhibitor descriptions. The predictive abilities for new inhibitor kinase combi nations and new kinases as assessed by outer loop cross validation are presented in Table 1. The most http://www.selleckchem.com/products/epz-5676.html predictive models were obtained using SVM, where for all three z scale based description methods the P2 values fell in the range 0. 70 0. 73 and the P2kin values in the range 0. 67 0. 70. The PLS and k NN models performed almost as good. Models based on AAC DC descriptors performed clearly worse than the z scale based descriptions, but also here the SVM model was the most predictive. the P2 being 0. 68 and P2kin being 0. 64, whereas the values of these parameters for PLS model were only 0.
58 and 0. 53. The inferior performance for the AAC Inhibitors,Modulators,Libraries DC descriptions is not surprising. In fact it seems quite unlikely that the fraction of any single dipeptide Inhibitors,Modulators,Libraries would show significant correlation with the Inhibitors,Modulators,Libraries functional properties of the kinases. Such correlations, however, can become evident for larger sets of dipeptide combinations, giv ing an advantage to the SVM model which by the use of its non linear kernel can approximate high complexity interaction effects between the descriptors. The differ ence between the performances of SVM and PLS models is even larger when proteins are described by CTD or by SO PAA descriptors. the P2kin for PLS models using these two sets of descriptors being, respectively, 0. 45 and 0. 44, compared to 0. 60 and 0. 63 for the SVM models.
For any set of descriptors the k NN method outper Inhibitors,Modulators,Libraries formed 1 NN. However, the optimal num ber of neighbours found to be used by the cross validation inner loop was quite low, and ranged in all cases 3 to 5. The predictions Inhibitors,Modulators,Libraries of k NN models are thus based on local subsets of the data set, and for this reason it would be problematic to use these models to draw any general conclusions on the molecular properties that determine kinase inhibitor complementarity. Finally, as expected, PLS modelling without use of kinase inhibitor cross terms explained only a minor part of the activity variation. the P2kin for all three z scale exploiting models being 0. 32. This result shows that the non linear part which describes kinase inhibitor selectivity dominate over the linear part that describes the average activity of a ligand for the protein series and the average activity of all ligands for a particu lar protein.
The selleck chem ARQ197 high non linearity in the dataset is also likely the reason for the moderate success of the decision tree algorithm, which for any of the six used kinase descriptions created a massive tree with over 300 leaves explaining 65 71% of the activity variation. However, all these trees suffered in ability to gen eralize to novel kinases. the P2kin for various descriptions ranging only 0. 30 0. 43.


Allow us to be of assistance. Fill out the Contact Form and you can be assured of receiving a reply to your query without delay. Lance and the Team at Leda Machinery (Qld) aim to provide you with the information you need to enable you to make the right choice in new and used Woodworking Machinery and Tooling for your business.


What is Alcohol-related Liver Disease (ALD)?
ALD is caused by excessive consumption of alcohol. Over many years this can result in serious and permanent damage to your liver. Each time your liver filters alcohol, some of the liver cells die. The liver can develop new cells (known as regeneration), but prolonged alcohol misuse over many years can reduce its ability to regenerate. This can result in serious and permanent damage to the liver.
Alcoholic fatty liver disease (steatosis): excessive alcohol consumption causes fat to build up in the liver. It often goes unnoticed because it does not tend to cause any symptoms. It is very common amongst people who drink heavily but it will normally go away if you stop drinking alcohol.
Alcoholic hepatitis: the liver cells become inflamed. Inflammation is the body's natural means of protecting itself from harm. Ongoing inflammation causes scar tissue to build up. When the scar tissue builds up faster than it can be broken down and removed this is known as fibrosis. Even if significant levels of fibrosis are present the liver is generally still able to function normally. If you stop drinking alcohol there is a good chance that the liver will recover from this damage over time.
Cirrhosis: If a person continues to consume too much alcohol the inflammation and fibrosis will continue to spread. Over time, usually many years, this can lead to cirrhosis which is where the amount of fibrosis has become so extensive that it will prevent the liver from being able to function normally.
How do you get ALD?
ALD is caused by excessive consumption of alcohol. This can either be caused by binge drinking an excessive amount of alcohol over a relatively short space of time or by consistently drinking more than the recommended limits of alcohol over many years.
In the early stages of the disease there are often no noticeable symptoms. Only when the liver is badly damaged do symptoms become more obvious.
As ALD progresses to alcoholic hepatitis, it is also possible to experience fever and jaundice (yellowing of the whites of the eyes and skin).
ALD can eventually progress to cirrhosis. To find out more about the symptoms of cirrhosis click here.
Diagnosis is often made via a blood test called a Liver Function Test (LFT). This test measures levels of enzymes and proteins which indicate how well the liver is working. When the results of this test are judged to be abnormal it can indicate a problem in the liver. However, even if you have ALD the results of this test may still show that the liver is working normally.
Once the condition has been diagnosed further tests may be required to assess which stage of the disease is present.
An abdominal ultrasound scan and/or a Fibroscan (a specialist type of ultrasound) may be used to assess whether or not cirrhosis is present.
A liver biopsy can give a more precise assessment of how much fibrosis is present.
What is the treatment for ALD?
If you have been diagnosed with alcohol-related hepatitis or cirrhosis the only way to prevent further liver damage is to give up drinking alcohol completely. Depending on the extent of the existing damage the liver may begin to repair itself once alcohol consumption is stopped.
Many people who have alcohol-related health problems aren't alcohol dependent. Despite not being alcohol dependent it can still be very difficult to stop drinking, particularly in cultures where drinking alcohol is strongly associated with social events.
If you are physically addicted to alcohol, medical supervision may be required to safely reduce your alcohol levels. It can be dangerous to stop drinking very suddenly. Your doctor can recommend the best form of treatment for you.
Is there any support for ALD?
What do patients with ALD say about LiverMultiScan?
Click here to read an account from a patient with ALD who took part in the Patient LiverMultiScan study.


text:
EU will participate in the construction of the US lunar orbital station and will be given the opportunity to dispatch astronauts
European Space Agency Space Control Center.
On October 27, the European Space Agency announced that the Director of the Agency Werner and NASA Director Bridenstine have signed a mutual memorandum of understanding, agreeing that the European Space Agency will be the US "Gateway" for the lunar orbit. The station will build two cabins and will have three opportunities to send European astronauts to the orbital station.
According to a report by the Russian Satellite News Agency on October 28, the memorandum confirmed that the European Space Agency will manufacture at least two service modules for the US "Orion" manned spacecraft. In addition, the European Space Agency will also build a main housing module for the US "gateway" lunar orbit station, as well as an on-orbit refueling and communication service module with portholes. The memorandum also stated that the European Space Agency will have three opportunities to send European astronauts to the "Gateway" lunar orbital station.
The United States is planning to build a lunar orbital space station called the "Gateway" and will invite project partners from the International Space Station to participate. US President Trump has signed the "Space Policy No. 1 Directive" and announced the United States' "Return to the Moon Program", that is, the United States will re-send astronauts to land on the moon and finally achieve a manned landing on Mars. The "Gateway" lunar orbiting space station is part of this plan. The mission of the station is to become an outpost for mankind to explore the moon and carry out manned missions to Mars.
Currently, Japan has expressed interest in joining. It is expected that SpaceX's Falcon Heavy launch vehicle will send the Energy and Propulsion System (PPE) and Habitation and Logistics Module (HALO) of the "Gateway" space station to lunar orbit in 2023.
The Russian Aerospace Corporation and NASA signed an agreement on the joint construction of the lunar orbital station in 2017. But then Rogozin, president of the Russian Aerospace Corporation, said that Russia could not participate in the project because the role assigned by the US to Russia was not important enough.
Tags: EuropeUnited States
133 technology business leaders jointly sent a letter to Trudeau warning "Canada will regress"
Indian statues were shot in the head during the baptism ceremony and 27 people were injured in police clashes


text:
FBI urges police to watch for people carrying almanacs
I couldn't make this up if I tried. According to an article in the Associated Press by Ted Bridis" the FBI has urged police to look for people who are carrying almanacs, saying that terrorists may use the reference books…
Simson Garfinkel '87, PhD '05archive page
I couldn't make this up if I tried. According to an article in the Associated Press by Ted Bridis,, the FBI has urged police to look for people who are carrying almanacs, saying that terrorists may use the reference books "to assist with target selection and preoperational planning."
Interestingly, the only refernce to almanacs that I could find on the FBI's website is this 1996 article by Captain Andrew J. Harvey of the Covina, California, Police Department, urging that "law enforcement agencies must prepare now to meet the challenges of policing in the 21st century."
Next thing you know, the FBI's going to be going after people using web browsers.
by Simson Garfinkel '87, PhD '05
emaillink opens in a new window
A Roomba recorded a woman on the toilet. How did screenshots end up on Facebook?Eileen Guo
A startup says it's begun releasing particles into the atmosphere, in an effort to tweak the climateJames Temple
10 Breakthrough Technologies 2023The Editors
These exclusive satellite images show that Saudi Arabia's sci-fi megacity is well underwayMark Harris
Our best illustrations of 2022
Our artists' thought-provoking, playful creations bring our stories to life, often saying more with an image than words ever could.
Stephanie Arnettarchive page
How CRISPR is making farmed animals bigger, stronger, and healthier
These gene-edited fish, pigs, and other animals could soon be on the menu.
Jessica Hamzelouarchive page
The Download: the Saudi sci-fi megacity, and sleeping babies' brains
This is today's edition of The Download, our weekday newsletter that provides a daily dose of what's going on in the world of technology. These exclusive satellite images show Saudi Arabia's sci-fi megacity is well underway In early 2021, Crown Prince Mohammed bin Salman of Saudi Arabia announced The Line: a "civilizational revolution" that would house up…
Charlotte Jeearchive page
10 Breakthrough Technologies 2023
Every year, we pick the 10 technologies that matter the most right now. We look for advances that will have a big impact on our lives and break down why they matter.
The Editorsarchive page
Illustration by Rose Wong
Get the latest updates from
Discover special offers, top stories, upcoming events, and more.
Thank you for submitting your email!
Explore more newsletters
It looks like something went wrong.
We're having trouble saving your preferences. Try refreshing this page and updating them one more time. If you continue to get this message, reach out to us at customer-service@technologyreview.com with a list of newsletters you'd like to receive.


Maxwell works at Adobe as a product evangelist. He's spent 12 years in translation and localization with more than 20 years working in traditional technical documentation.
We've come full circle in terms of our hand-held devices. We've gone from cuneiform tablets to scrolls to desktop computers and now back to hand-held smartphones. This means our content must be in shorter pieces, faster to load, and easier to scan.
The biggest barrier to good translation in Maxwell's mind is poor English. The more complex the language, the harder the translation. Simplifying your docs and your language simplifies your translation. For hand-held devices this helps as simplified English by as much as 30%. We can all benefit from writing simplified English.
Use one topic per sentence.
Do not use gerunds (-ing words).
Use valid nomenclature & abbreviations.
To work on these rules try writing an outline on a typewriter. With this you can only write; there are no distractions. There's no editing or formatting. You will feel and write differently. Or, if typewriters aren't you thing, you can break long sentence writing patterns by dictating your writing.


text:
Is a Mercedes-Maybach 6 convertible headed to Pebble Beach?
Latest Pebble concept promised to be another 'icon' for reborn sub-brand
By Jay Ramey
The annual Pebble Beach Concours d'Elegance has turned into a small luxury auto show right before the Frankfurt or Paris motor shows, with luxury automakers filling the increasingly jammed Concept Lawn with dramatic concepts created just for the concours. This practice has noticeably picked up in recent years, and automakers now use the concours for gauging customer interest in front of those with the money to buy just about any car in the world.
A recent Instagram video posted by Mercedes-Benz design boss Gorden Wagener is now teasing, via some intended misdirection, a new Mercedes-Maybach concept expected to take to the concept lawn at Pebble this year, with Mercedes designers shuffling around sketches of past concepts including the Vision Maybach 6 concept coupe that debuted at Pebble in 2016.
Autocar reports the concept due at Pebble will be a drop-top version of the Mercedes-Maybach 6 but hasn't cited firm production plans for the model.
The four-wheel-drive 2+2 EV seen last year produced a total of 738 hp through its four electric motors, drawing juice from an underfloor battery, and it was said to be capable of sprints from 0-60 mph of under 4 seconds while boasting a range of more than 200 miles. The sleek 18.5-foot-long coupe sat on 24-inch wheels, as if intending to crowd out other Pebble concepts through sheer square footage alone, and featured a chrome grille said to have been inspired by pinstripe suits. The concept also featured a number of classic Mercedes and Maybach design elements along with gullwing doors, plus a Star Trek-style interior.
The second-most-recent revival of Maybach never actually produced a convertible version when the W140-generation Maybach lineup was its own separate brand, only offering what we'll graciously call a president-for-life Landaulet model. The Landau retained the C-pillars and rear doors of the Maybach 62 sedan, with the only open section being a retractable canvas roof for the rear seat passengers (permitting them to wave at adoring throngs of citizens). Maybach was criticized at the time for not offering a simple two-door cabriolet priced akin to the short-wheelbase 57 sedan, which could have helped sales in the sunnier tax havens.
It remains to be seen whether Mercedes-Maybach will field a production cabriolet, but with the S-Class Cabriolet already on the market, it will surely be easy for the automaker to develop an even more luxurious model based on it.
The earlier iteration of the Maybach brand produced the lavish 62 Landaulet for a short period of time towards the end of the model run, but Maybach had not fielded a true drop-top at the time.
Jay Ramey Jay Ramey grew up around very strange European cars, and instead of seeking out something reliable and comfortable for his own personal use he has been drawn to the more adventurous side of the dependability spectrum.
More From Concours
2022 Detroit Concours d'Elegance Gallery
Pebble Beach Concours d'Elegance Picks Duesenberg
Greenwich to Feature Vignale, Chrysler Letter Cars
Rhinebeck Gears Up for Spring Car Show in May
Here's What Greenwich Has in Store for June
Greenwich Concours Is Back This Weekend
Audrain's Newport Concours and Motor Week Begins
Pebble Beach Concours to Be Broadcast Live
Why Does This Horch Keep Winning Everything?
Petersen Museum Will Host a Virtual Pebble Beach


text:
Start With A Free Consultation: 203-285-3593
Start With A Free Consultation
Learn More About Our Practice
Practice Area Overview
Medical And Professional Malpractice
Liability, Claims, Litigation And Defense
Recreational/Sports Injuries
See Why Our Clients
Trucking accident leads to death of boy on bicycle
On behalf of Williams, Walsh & O'Connor, LLC posted in Truck Accidents on Thursday, August 7, 2014.
A young boy sadly passed away following a vehicle crash involving a box truck in Connecticut. It's understandable for the boy's parents and other family members are likely heartbroken. The trucking accident occurred when the boy was riding his bike on a recent Thursday afternoon, according to authorities.
Police said that while the boy was on a bicycle, spending with several other children near a middle school, a box truck hit him. The boy, who attended the school, suffered grave injuries and was transported to the hospital. He later died there, officials said.
The truck driver remained at the accident scene, and no charges were filed in the immediate aftermath of the tragedy. Police closed down the area of the accident for a few hours while they investigated the cause of the collision. Residents said bicyclists were vulnerable on the street where the accident took place, as that road was typically busy. Counselors were made available to help students after the boy's sudden death.
In addition to following the progress of the police investigation concerning the trucking accident, the grieving family of the dead child might benefit from seeking an independent investigation to focus on all of the circumstances and facts surrounding the fatal crash. If the truck driver is found to have caused the accident due to negligent actions, such as driving while distracted, the driver and the driver's employer could be held financially responsible for the child's fatal injuries. The family may pursue claims for the reimbursement of monetary losses sustained as a result of the accident, such as the child's funeral expenses and other accident-related expenses in Connecticut.
Source: wfsb.com, "Suffield Middle School student struck, killed while riding bike", Joseph Wenzel IV, Courtney Zieller and Rachel Rooney, July 24, 2014
Tags: Trucking accident, police investigation
Related Posts: Semi-truck accident results in 1 death, 1 injury, Truck accidents in Connecticut can cause serious injuries
Back Injury (1)
Bus Accidents (3)
Group home injuries often go unreported in Connecticut
What types of injuries can occur at public pools?
Summer weather leads to more pedestrian accidents
Can you sue your mental health counselor for negligence?
Request A FREE Consultation.
Let's Do This Together.
Call or use our form below to tell us about your case and we'll get back to you promptly.
Spanish and Indian language
services are available, and we
also speak French.
37 Broadway, 1st Floor
North Haven Law Office Map
© 2019 by Williams, Walsh & O'Connor, LLC. All rights reserved. Disclaimer | Site Map


text:
Home Android
Google Adds Verified SMS And Spam Protection For Messages On Android
Kavvitaa S Iyer
Google on Thursday announced the rollout of two new features in the Messages app for Android users.
The first feature is called "Verified SMS". This will help the user confirm the true identity of the business that's texting them.
The feature works by verifying, on a per-message basis, that content is sent by a specific business. If the message is verified, Google will display the business name and logo as well as a verification badge in the message thread.
Some of the first brands like 1-800-Flowers, Banco Bradesco, Kayak, Payback, and SoFi sent messages with Verified SMS starting yesterday. Google Pay India and verification codes from Google will also be enrolled in Verified SMS.
This new Verified SMS for Messages feature has been rolled in nine countries, starting in the U.S., India, Mexico, Brazil, the U.K., France, Philippines, Spain, and Canada with more countries to follow.
Another feature is "Real-time spam detection" that will protect you from spam in Messages.
With Spam protection for Messages, Google warns you of suspected spam and unsafe websites that have been detected by it.
You can help improve Google's spam models by marking specific messages as spam. You can also report spam text messages at any time and block the sender from sending any more future texts.
Although this feature has already been available for the past year in some countries, it is now rolling out widely in the U.S.


If dark matter is puzzling, then dark energy is a complete enigma.
As mentioned previously, supernovae are enormously important distance indicators.
billions of light years away.
it can be treated as a standard light bulb or a standard explosion in the universe.
Enabling us to measure the distance to a far-off galaxy.
attempts to trace this back further out in space and further back in time.
the Earth, that's a small fraction of the age of the universe.
velocity, extending now out to distance of a billion light years or more.
even before, astronomers speculated that they should see something interesting.
When galaxies were closer together, their mutual gravity was larger.
because of the mutual gravity of galaxies acting on each other.
Therefore, the universe should be decelerating in its expansion rate.
expanding faster than it is now, because it's been decelerating.
they anticipated seeing the slope of the Hubble relation steepen.
The expansion being faster or at least the same speed in the past.
What they saw was the complete opposite.
They saw that the expansion rate in the distant past was actually slower.
Meaning, the universe has accelerated in its speed.
This was not just a surprise, it was completely inexplicable.
The force of gravity should act to slow down the expansion.
Nobody could think of a force that would make the expansion speed up.
One, led by Adam Riess at the Space Telescope Institute.
And the other, led by Saul Perlmutter at Lawrence Berkeley Lab.
shocking and so unanticipated that each group questioned their own results.
But the results stubbornly persisted.
The universe seems to be accelerating in its expansion rate.
since it's the only underpinning for the measurement of dark energy.
30% fainter than they expected.
in a model where no dark energy was present.
to larger distances, that would be the acceleration they observed.
The observation just talks about acceleration.
It says nothing about what causes it or the physical nature of that.
gravity to force the universe to move faster and faster.
to the earlier phase when the universe was decelerating.
that describe its behavior in the past and on into the future are both mysterious.
the other is dark energy, acting to increase the expansion rate.
It's as if the universe has a brake and an accelerator.
which is why the universe is currently accelerating.
more since the dark energy discovery, the level of measurement has increased.
But the basic result has not gone away.
dark energy as well as the direct argument based on supernovae.
The indirect argument is the observation from the early universe.
Using microwaves, the space is flat.
curved on very large scales, positively or negatively, it seems to be flat.
if the universe contains more of than the dark matter we see with our observations.
Dark energy appears to be necessary to explain flat spacetime.
are governed by dark matter and a decelerating expansion rate.
the dilution of that matter in expanding space.
Essentially, the space density of dark matter declines as the volume increases.
So the strength of dark energy hasn't changed since the Big Bang.
And as dark matter got diluted, dark energy started to take over.
the universe has been accelerating.
we don't anticipate that this acceleration will ever reverse.
of something we'll call dark energy.
neither physics nor astrophysics provides an answer.
As with dark matter, dark energy is beyond the standard model of particle physics.
have the right attribute or strength to explain the accelerating universe.
our measurement of dark energy by an order of magnitude.
they will measure something called the equation of state of dark energy.
We will learn whether dark energy is invariant across time and space.
An ambitious probe to measure dark energy with better accuracy than at present.
It's a multi-billion dollar mission currently unfunded.
Why is dark energy so puzzling for physicists as well as astronomers?
Physics contains the concept of energy in the pure vacuum of space.
Quantum theory says that the vacuum is not truly empty.
There's a tiny residual amount of quantum energy, a half-age new in quantum theory.
on very large scales in the universe, there's a real problem.
The amount you calculate is off by 100 or 120 orders of magnitude.
compared to the delicate amount of vacuum energy causing the accelerating expansion.
a close balance between dark matter and dark energy.
this is the only time at which they would be similar within a factor of two.
For most of the distant past, dark matter far dominated dark energy.
infinite future, dark energy will far dominate dark matter.
The fact that they're so close in strength now seems to be a coincidence.
And yet they're physically unrelated, as far as we can tell.
relates dark matter to dark energy?
At the moment, we have no idea.
With dark energy, we're left with far more questions than answers.
Our observational traction on the issues are slender.
Physicists, meanwhile, are speculating theoretically.
There are perhaps 300 papers a year written about dark energy.
Unfortunately, very few ways to test those ideas.
supergravity, quantum theories of gravity that unify the four forces of nature.
Such speculative physics is far beyond the realm of astronomical observation.
simple reasons of particle physics.
energy in the form of particle/antiparticle pairs.
These appear and disappear on tiny timescales.
all the possible particle/antiparticle pairs, and their myriad branching points.
Physicists are working on these problems.
But at the moment, we're no closer to understanding what dark energy truly is.
Conceptually, there are several possible outcomes for the universal expansion.
the expansion to reverse, and the universe to collapse in a big crunch.
Present observations essentially ruled that out as an outcome.
decreasing rate, coasting to a maximal size in the infinite future.
That outcome also seems to be ruled out by observations.
the infinite future, carrying the galaxies faster and faster apart from each other.
the galaxies will be carried away from each other faster than the speed of light.
And so be removed from the view of our telescopes.
I'm an extragalactic astronomer, so I'm having fun while I can.
In a few billion years, it may not be possible to observe any other galaxies.
it dominates the cosmic expansion.
Dark energy was implicated by observations of supernovae 18 years ago.
accelerating because of some entity that works opposite to gravity.
Essentially repulsive instead of attractive.
the physical effect required to explain the accelerating universe.
which only occurs once in the history of the universe.


text:
Grażyna Godlewska, z d. Kozioł (ur. 25 lutego 1950 w Tarnowie) – polska siatkarka, mistrzyni i reprezentantka Polski.

Życiorys
W reprezentacji Polski debiutowała 3 maja 1967 w towarzyskim spotkaniu z Węgrami. Wystąpiła na mistrzostwach świata w 1974 (9. miejsce) oraz mistrzostwach Europy w 1977 (4. miejsce). Zakończyła karierę reprezentacyjną meczem mistrzostw Europy z Węgrami - 2 października 1977. Łącznie w I reprezentacji Polski wystąpiła w 105 spotkaniach. W 1969 wystąpiła też na mistrzostwach Europy juniorek, zdobywając z drużyną brązowy medal.

Była wychowanką MKS Tarnów, następnie występowała w barwach Tarnovii, AZS Kraków, AZS Warszawa (1970–1972) i od 1972 Płomienia Milowice. W barwach tej ostatniej drużyny zdobyła mistrzostwo Polski w 1974 i 1975.

Bibliografia
 Krzysztof Mecner 80 lat polskiej siatkówki, b.m. i d.w.
 Roman Kieroński, Robert Noga Tarnowski sport od A do Ż, wyd. S-Can, Tarnów 2011

Reprezentantki Polski w piłce siatkowej
Urodzeni w 1950
Ludzie urodzeni w Tarnowie

redpajama_set_name: RedPajamaWikipedia


text:
About Cardiff West
Constituency Surgery
HomeAssembly NewsNew HPV vaccine programme for gay men to be introduced in Wales
New HPV vaccine programme for gay men to be introduced in Wales
Category:	Assembly News
A new HPV vaccination programme for men who have sex with men (MSM) will be introduced in Wales, Health and Social Services Minister Mark Drakeford announced today.
The decision comes after the Joint Committee on Vaccination and Immunisation (JCVI), which provides independent, expert advice to governments across the UK, recommended the introduction of such a targeted programme.
Since the introduction of the HPV vaccination programme – which protects against strains of the human papilloma virus linked to cervical cancer – for adolescent girls in 2008, evidence has emerged that HPV immunisation can provide protection against a wider range of cancers which may be more commonly seen in gay men.
The new programme will be targeted at men aged 16 to 45 who have sex with men and who attend specialist sexual health clinics. The JCVI has also recommended the vaccine is offered to other people who are considered to be at risk, including MSM who are over 45, sex workers and HIV-positive men and women on a case-by-case basis.
The JCVI is still considering whether it would be beneficial to offer the HPV vaccine to all adolescent boys. A recommendation is expected in early 2017.
In his capacity as Health and Social Services Minister, Mark said:
"Men who have sex with men are a group who receive little indirect protection from the highly-successful HPV vaccination programme for adolescent girls.
"I'm pleased to announce that I have approved the introduction of a new targeted HPV vaccination programme for men who have sex with men up to the age of 45.
"We will now give careful consideration about how this programme will be delivered and will make a further announcement in due course."
UK Labour Party
Welsh Labour Party
Kevin Brennan MP (Cardiff West)
Mark Drakeford AM, Ty Hywel, National Assembly for Wales, Cardiff Bay, Cardiff CF99 1NA


text:
package scala.slick.driver

import java.sql.PreparedStatement
import scala.slick.jdbc.MutatingStatementInvoker
import scala.slick.lifted.Query
import scala.slick.jdbc.{PositionedParameters, PositionedResult}
import scala.slick.util.RecordLinearizer

class JdbcQueryTemplate[P, R](query: Query[_, R], driver: JdbcDriver) extends MutatingStatementInvoker[P, R] {

  protected lazy val sres = driver.buildSelectStatement(query)

  def selectStatement = getStatement

  protected def getStatement = sres.sql

  protected def setParam(param: P, st: PreparedStatement): Unit = sres.setter(new PositionedParameters(st), param)

  protected def extractValue(rs: PositionedResult): R = sres.linearizer.narrowedLinearizer.asInstanceOf[RecordLinearizer[R]].getResult(driver, rs)

  protected def updateRowValues(rs: PositionedResult, value: R) = sres.linearizer.narrowedLinearizer.asInstanceOf[RecordLinearizer[R]].updateResult(driver, rs, value)
}

redpajama_set_name: RedPajamaGithub