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Nokia Asha QWERTY Promo Essay Writing Contest in the Philippines, Out! Win Nokia Asha 200 and Nokia Asha 303!
TP Friends, you all know how much I love Nokia so I hope all of you can join this promo and treat it like a true TPGB!
Totally reinforcing the insider info that I go a few hours ago regarding Nokia Asha 300's imminent release in our country, I just received an email from Nokia Philippines about their new 'Why do you QWERTY!' promo, which gives everyone a chance to take home either a - get this - Nokia Asha 200 or Nokia Asha 303 QWERTY handset!
Nokia Asha 303 in Silver White. Cute, eh?
The contest is open to all QWERTY phone users. All you have to do is write a 200-word essay on the topic: "How using a QWERTY phone changed my mobile life for the better."
Your essay should describe your positive experiences and interesting anecdotes about using your QWERTY phone. In short, write it well and make it engaging!
Your essay should be accompanied by a photo in JPEG format of yourself and your QWERTY phone. Send your entry via email to nokiaqwertypromo[at]ovi[dot]com.
Four entries with the most interesting stories and the most creative photos will win a new Nokia QWERTY phone each: a Nokia Asha 200 for the 3rd prize; a Nokia Asha 303 for the 2nd prize; a pair of Nokia Asha 200 for the 1st prize; and a pair of Nokia Asha 303 for the grand prize.
The Nokia Asha 303 is a touch screen device with a full physical QWERTY keypad. This stylish and slim device has lots of processing power that gives a rich web-browsing experience and quick-access to social networking applications. Likewise, it lets you stay connected to your loved ones and lets you have fun with great apps and its music player.
The Nokia Asha 200 is ideal for young, urban consumers who find QWERTY phones aspirational and wish to connect to their social networks, but are also very price conscious. It is suited for their need to send messages quickly, for listening to music, and most importantly for having control over costs with the Easy Swap function.
Deadline of submission of entries is on December 30, 2011. Join now, TP Friends!


This is not just a wine shelf, it can also be used as a household adornment. Designers make the cold iron into a lovely and gentle lion, especially for its mane, looks so lifelike. And with the high-quality environmental baking varnish technology, it has a good protection from rusting. Overall, it's a great gift choice.


Lynn Brezosky Nov. 5, 2015 Updated: Nov. 5, 2015 8:50 p.m.
CPS Energy interim CEO Paula Gold-Williams said Thursday she doesn't know whether she is among the eight finalists the board of the city-owned utility is considering to replace former CEO Doyle Beneby.
"I don't know. I've never asked them who's on that list," Gold-Williams told reporters after giving a presentation as part of the Forum on Entrepreneurship Breakfast Series hosted by the Meadows Center for Entrepreneurial Studies at St. Mary's University.
The CPS board appointed Gold-Williams interim CEO effective Nov. 1. She had been serving as group executive vice president and chief financial officer.
Beneby in August announced he was leaving CPS to join Chicago-based renewable energy company New Generation Power International. He declined CPS trustees' new contract offer but had agreed to stay on through Oct. 30.
Board Chairwoman Nora Chávez last week said trustees were narrowing a list of eight contenders that included an undisclosed number of in-house candidates.
Gold-Williams, a San Antonio native and St. Mary's University graduate, said her successful career path — she rose through the ranks at Time Warner Cable and Luby's Inc. before joining CPS Energy — came despite humble beginnings.
Her father served in the Air Force for 24 years, and she was born at Wilford Hall Medical Center at Lackland AFB. While she fell in love with accounting after taking a class at Sam Houston High School, her father persuaded her to take up something less stressful in college. She got a fine arts degree at San Antonio College, then went on to study accounting anyway at St. Mary's.
Her presentation detailed how the power company has grown and diversified. t generates more than $2.6 billion annually on about $11 billion in assets while delivering power to more than 1 million customers.
CPS has committed to deactivating its J.T. Deely coal-powered plant by 2018 and reducing emissions equivalent to what's produced by 1.5 million cars. It's been partnering with renewable energy companies including OCI Solar Power, Silver Spring Networks and Mission Solar Energy.
The utility is currently at 10 to 11 percent renewables; the goal is about 20 percent.
The company also is looking at battery storage that could make power delivery more reliable and less centralized.


Are you interested in joining the fast-paced world of international finance? Whether you dream of becoming an accountant, investment broker or financial advisor, this full-time degree will help equip you with the skills you'll need to get your career off to a great start.
This programme aims to help students to take advantage of these graduate jobs by providing them with a solid understanding of the industry, the opportunity to pursue work experience and the chance to engage with specific areas of finance that interest them. Students on the BA (Hons) Accountancy and Finance course study intensively, looking at both national and international markets to ensure a firm understanding of the global economy.
The curriculum itself is partly based around first hand advice and real life examples of working in the industry. Not only does this better prepare students for their working life, it also ensures that staff and students are keeping up to date with the latest developments in this fast moving industry.
Our accrediting institutions can provide students with support and guidance both during and after their degree. This support has helped past students to secure year-long work placements, which every students is given the opportunity to undertake between the second and third years of their degree.
Solent is a place of study for students from all over the world. Learning with students from a wide range of different backgrounds helps to emulate real working practises and brings new points of view to discussions and debates.
Solent graduates are exempt from up to two-thirds of Association of Chartered Certified Accountants (ACCA), Chartered Institute of Management Accountants (CIMA) and Association of International Accountants (AIA) exams as you will be taught the relevant content as part of the course.
Providing general business and finance which are valuable in almost any career path, the course opens up the door to a wide range of accounting and finance positions.
Previous students have gone on to work in a wide range of businesses and organisations, with recent graduates finding roles at Ernst and Young, PWC and Vodafone.
This course is ideal for anyone who is hoping to pursue a career as an accountant, investment broker or financial advisor.
Students who are interested in becoming a member of a professional body will benefit greatly from graduate exemptions for ACCA, CIMA and AIA exams.
Alternative entry on this course is available through the Business Foundation Year.
Transferable skills you will learn include: numeracy, IT, project management, group working, time management, communication, analysis and problem-solving skills.
Most accounting units are assessed through 50 per cent coursework and 50 per cent exams. Some options may be 40/60 per cent weighted, or possibly 100 per cent coursework-based.
You will produce a research dissertation, which gives students the chance to independently use the analytical skills learnt throughout the course and focus on an area of finance that most interests them.
The course is classroom-based with supporting IT workshops to help you develop IT skills in Excel and professional accountancy packages.
The academic team who deliver this course have first-hand experience of the finance industry, gained from time spent in a range of different roles. Students will benefit from a high level of contact time with lecturers.
Finance is fast-moving, complex and ever-evolving – an industry that's adding billions to the UK economy each year. Employers in this challenging environment are always looking for motivated and intelligent students to fill a variety of graduate roles.
Students will have access to a wide range of facilities during their time here at Solent. These include modern IT suites and a variety of sports and entertainment facilities (which are available to all Solent students on an extracurricular basis). The University also provides excellent learning resources to its students, from campus-wide wireless to extensive library services and dedicated student work spaces.
Our accreditations from ACCA, the Institute of Chartered Accountants in England and Wales (ICAEW), and AIA show potential employers that Solent's teaching meets the standards set by the industry itself.
There are a various optional units built into the course, allowing students to specialise in a specific area of accountancy and finance, or gain a broad understanding of the industry.
Graduates often go on to study professional accountancy qualifications as part of training selected by their employer, or go on to study at master's level.
Solent University is ideally suited to providing students with the practical skills needed in the work place. This is down to the practical, hands-on nature of its courses compared to other universities.
I love the way course has been brought together with the units it offers and the way lecturers involve themselves in helping and guiding students in preparing assignments. I like the supportive and helping environment of university. Moreover, the guest lectures that I attended during the employability week were very helpful as I got to know the importance of getting a job in SMEs.
I like the fact its located right in the centre of Southampton making everything a walking distance. There are also a lot of good facilities and friendly staff that are always willing to help.
Many of the teaching staff have professional experience in accountancy and the financial sector. This ensures that study units reflect current developments in the industry. The curriculum looks at both the national and the international finance industry, keeping students up to date with the global economy and giving them the option of pursuing a career abroad after graduation.
You'll also have access to professional guest speakers, links with local employers, live assessment briefs and an optional placement between years two and three, giving you a chance to get practical hands-on experience and develop valuable professional connections.
In previous years, the accountancy and finance course team have used their connections with practising professionals to arrange live briefs, guest lectures and work experience placements.
You have the option of undertaking a year in the industry between the second and third years. In finding a suitable placement you'll be able to use the course team and the University's contacts and resources, and further support is available.


text:
import json

import frappe
from frappe.model.document import Document
from frappe.utils.safe_exec import read_sql, safe_exec

class SystemConsole(Document):
	def run(self):
		frappe.only_for("System Manager")
		try:
			frappe.local.debug_log = []
			if self.type == "Python":
				safe_exec(self.console)
				self.output = "\n".join(frappe.debug_log)
			elif self.type == "SQL":
				self.output = frappe.as_json(read_sql(self.console, as_dict=1))
		except Exception:
			self.output = frappe.get_traceback()

		if self.commit:
			frappe.db.commit()
		else:
			frappe.db.rollback()

		frappe.get_doc(dict(doctype="Console Log", script=self.console, output=self.output)).insert()
		frappe.db.commit()

@frappe.whitelist()
def execute_code(doc):
	console = frappe.get_doc(json.loads(doc))
	console.run()
	return console.as_dict()

@frappe.whitelist()
def show_processlist():
	frappe.only_for("System Manager")

	return frappe.db.multisql(
		{
			"postgres": """
			SELECT pid AS "Id",
				query_start AS "Time",
				state AS "State",
				query AS "Info",
				wait_event AS "Progress"
			FROM pg_stat_activity""",
			"mariadb": "show full processlist",
		},
		as_dict=True,
	)

redpajama_set_name: RedPajamaGithub


There are 11 files totaling 298KB in this category.
Like the Gameboy game, where you must move blocks into their positions (like Sokoban). Contains 165 levels. Requires ShellOS.
A powerful and easy to use assembly language debugger, part of the forthcoming programming development kit for SHELL OS.
A SHELL adaptation of the famous game found elsewhere on my site. Requires ShellOS.
Directory containing various fonts for use with ShellOS.
A tool to view the contents of memory, useful to understand how the OS manages the memory.
Simple memory scanner and hexidecimal editor.
A replacement Unix-like operating system for the HP 48 with multitasking, completely written in assembly language, designed to change the HP 48 into a "palmtop computer." Incompatible with the built-in RPL OS; requires a 32k or 128k RAM card in slot 1. Also includes some applications, like the filer, a paint program, and a text editor.
Documentation for ShellOS 3.0 Beta 2.4 in PDF format.
Screen capture program for SHELL and its applications.
Very small grayscale implementation of Tetris. Requires ShellOS.


Your gift provides the margin of excellence in all we do. Thank you!
Help our faculty and students build leading financial management education and research.
Help our PhD students with new computers and equipment, travel stipends and submission fees to support their studies and research.
In recognition of Don Seeley's contributions to the Department, donations will provide long-term support for excellence in research and teaching in finance.
Your donation supports students scholarships for finance majors with financial need.
For more information, or to discuss your investment in the Department of Finance, please contact us.


text:
Covering Jersey
Covering Jersey - Covering Jersey
In cop killer's case, top court weighs recidivism fears against redemption
Wendy Powell Jan 31, 2022
At 85, Sundiata Acoli is a sick old man and an obedient prison inmate, his hearing fading as quickly as dementia takes hold, his supporters say. But Acoli is also a convicted cop killer whose words can't…
Governor Murphy and Lieutenant Governor Oliver Announce Appointment of State Senator Chris A. Brown,…
Governor Phil Murphy and Lieutenant Governor Sheila Oliver today announced that State Senator Chris A. Brown, Esq. will join the Department of Community Affairs' Division of Local Government Services as the Senior Advisor for Atlantic City…
Science Park on Technology: Newark Public Schools Holiday Tournament – Boys' Basketball…
Science Park capitalized on a strong second-half performance to defeat Technology 60-47 in a first-round game of the Newark Public Schools Holiday Tournament in Newark.This tournament was supposed to be played in December but has been…
Three men charged in the Mayren-Guzman case to appear in court this week | Local News
Michael Smoliga Obituary (1994 – 2022) – Hamilton Square, NJ
HAMILTON SQUARE Michael RZ Smoliga, 27, of Hamilton Square, NJ passed into the hands of our Lord on January 26, 2022 after an extended hospitalization following a car accident in October 2020. He was born in Trenton on April 7, 1994 to…
Governors attempt to bridge deep political divides in big D.C. meeting
WASHINGTON — Governors of both parties from throughout the United States met here over the weekend to try to speak on a unified front about what their states need from the federal government. But the waters were muddied by governors'…
Paterson NJ Police Department recruits go to training
PATERSON — City officials are sending 23 new recruits to train at the police academy, but Paterson will miss his law enforcement staffing target because nine applicants failed drug screening or physical fitness tests.The goal had been to…
Get rid of that mess of wires with MagStack's 3-in-1 wireless charging station – ^
This 3-in-1 wireless charger is the ultimate portable charging station. The MagStack Foldable 3-in-1 Wireless Charging Station is the perfect way to keep all your…
Trump's fake electors: Here's the full list
The 84 people who signed bogus documents claiming that Donald Trump won the 2020 election include dozens of local Republican Party leaders, seven current candidates for public office, eight current office holders and at least five previous…
More like Maine? South Jersey near the top when it comes to Northeast total snowfall |
Then came the "blizzard of 2022".An intense low-pressure area, with air pressure as low as a Category 2 hurricane, moved off the coast of Florida on Friday to a point east of Atlantic City and south of Cape Cod on Saturday. The airport and…
© 2023 - Garden State Gazette. All Rights Reserved.

redpajama_set_name: RedPajamaCommonCrawl


text:
Parameijerella mizoramensis är en tvåvingeart som beskrevs av Cherian 1991. Parameijerella mizoramensis ingår i släktet Parameijerella och familjen fritflugor. Inga underarter finns listade i Catalogue of Life.

Källor

Fritflugor
mizoramensis

redpajama_set_name: RedPajamaWikipedia


text:
President Putin: 'We are waiting for an end of this political confrontation' not ready to accept Biden
Cesar Munera | TheBL 11/23/20, 17:23
Russian President Vladimir Putin takes part in a video conference during the G20 Leaders' Summit 2020, at the Novo-Ogaryovo state residence outside Moscow on Nov. 21, 2020. (Sputnik/Aleksey Nikolskyi/Kremlin via Reuters)
Russian President Vladimir Putin said Sunday that the United States faces a problem in its electoral system, reaffirming in passing that he will refrain from congratulating Democrat Joe Biden as president-elect until the final election result is announced.
As Breitbart News indicates, Putin is among the few leaders who have refused to recognize Biden and his vice-presidential candidate, Kamala Harris.
He said he has no "ulterior motive" for such a decision and is just waiting for the outcome of the legal action brought by Trump's team in different states for election fraud.
"Formalities must be followed based on established practices and legal standards. There is no ulterior motive or anything that could serve to further degrade our relationship. It is a purely formal approach," Russian President Rossiya 1 told the station.
The Russian president said that it is merely a purely formal approach, stating that it is not that the Russian government has any preference.
"We are simply waiting for an end of this internal political confrontation," Putin said.
Putin added that the Russian government was willing to work with anyone who has the American people's confidence.
He took the opportunity to explain that he had not congratulated Biden because he disagreed with the U.S. electoral system, suggesting that the electoral college was not democratic.
"It is quite evident—it is clear for everyone in the world—it seems to me that it is clear for Americans, there are problems in the U.S. election system," Putin said.
"A candidate, who wins in this or that state, he gains all votes of the electors. For example, there are 20. Gained 11 but took all 20. But it may be that there are fewer voters behind these electors."
As the New York Post points out, President Trump has not yet recognized the election's outcome.
His legal team has taken legal actions in different states to expose the evidence about what he calls massive voter fraud.
Weeks ago, he said that legal disputes might end up in the Supreme Court. "It's not a question of who wins—Republican, Democrat; Joe, myself. We can't let that happen to our country. We can't be disgraced by having something like this happen," Trump said.
"We won these and many other victories despite historic election interference from big media, big money, and big tech," President Trump said Nov. 5, according to a White House statement.
For its part, the Russian government also has its sights set on censoring international social media platforms such as Facebook, YouTube, and Twitter. According to The Moscow Times, a bill was released last week to block them, arguing they have been censoring Russian State media.
The move, led by the Prosecutor General's Office and the Russian Foreign Ministry, plans to identify foreign platforms that restrict Russians' ability to publish content, allowing Russia's federal media regulator, Roskomnadzor, to block them in whole or in part.
No congratulations for Joe Biden unless election results are clear, says Russia's President Putin
Electoral fraud: Smartmatic's CEO acknowledges ceding software to Dominion in video
Election 2020: Conservative Supreme Court justices in charge in key states
Whistleblower evidence blows open the Biden family business dealings with the Chinese Communist Party, PLA and Russia
Tags:Russia Joe Biden 2020 presidential election President Putin
FBI declassifies first 9/11 document in response to Biden order
U.S. 09/12/21, 15:48
'This is unconstitutional': Republicans outraged at Biden's mandatory vaccination mandate
Biden to Republicans threatening lawsuits over vaccine mandate: 'Have at it'
RNC plans to sue Biden administration after he announces vaccine mandate for businesses
Stress made former President Trump look 'younger' says Donald Jr.
Biden will require all federal workers to have COVID-19 vaccine


Welcome to Water On Mars !
Where good old rivers (of news) have been discovered (again).
It's just a demo !
You can log in and try it with the username 'demo' and the password 'redh2o'.
WaterOnMars is currently running in demo mode, to use it for real feel free to fork it on github and install your own!
WaterOnMars is currently running in READ ONLY mode, no change will be allowed nor saved anyway.
Code licensed under GNU Affero GPL v3.0 and available on GitHub.
Icons by Glyphicons Free licensed under CC BY 3.0.
Built on Bootstrap, United theme, and Django.
WaterOnMars is a project initiated by Thibauld Nion.


text:
ACCEPTED

#### According to
International Plant Names Index

#### Published in
J. Jap. Bot. 62:368, fig. 2D, E. 1987

#### Original name
null

### Remarks
null


2007-2018 Jeep Wrangler JK Lift Kits & Suspension | Quadratec. jeep jk lift kit | eBay. Jeep Suspension Lift Kits - roughcountry.com. Jeep JK Lift Kits 2007-2018 Wranglers | ExtremeTerrain. The Best Jeep Lift Kits (Review & Buying Guide) in 2019 .... JK Wrangler & Rubicon ('07-'18) - Jeep Suspension Systems .... Metalcloak JK Wrangler Jeep Suspensions & Lift Kits. Jeep JK 1-2" Lift Kits 2007-2018 Wranglers | ExtremeTerrain. 2007-2018 Jeep Wrangler JK Lift Kits | Quadratec. Amazon.com: lift kit for jeep jk.


text:
A Dryophytes squirellus a kétéltűek (Amphibia) osztályának békák (Anura) rendjébe, a levelibéka-félék (Hylidae) családjába, azon belül a Hylinae alcsaládba tartozó faj. Fouquette és Alain Dubois 2014-es megállapítása szerint az eredeti kiadványban  említettekkel ellentétben ennek a fajnak az eredeti leírója nem Bosc, hanem Daudin francia zoológus.

Előfordulása

A faj az Amerikai Egyesült Államok délkeleti részén él Texastól Virginiáig. Természetes élőhelye nyílt erdők, lakott területek.

Megjelenése

A Dryophytes squirellus kis méretű békafaj, a kifejlett példány mérete körülbelül 40 mm. Számos színváltozata létezik, a leggyakoribb a zöld, de lehetnek sárgásak vagy barnák is, néha fehér vagy barna foltokkal.

Jegyzetek

Források

 Daudin, 1800 : Histoire naturelle des quadrupèdes ovipares, (eredeti publikáció).
 Amphibian Species of the World 6.0

További információk
 Herps of Texas: Hyla squirella
 Virginia békái

Az Amerikai Egyesült Államok kétéltűi
Kétéltűfajok
Dryophytes


Rudraksha Ratna brings you a grand exhibition (August 16 to August 26, 2018) featuring a variety of spiritual, meditational, Puja and Vastu gifts & items. Rudra Centre, a part of Rudraksha Ratna Group, has been organizing exhibitions and workshops on Rudraksha and their rare collections in India and abroad for years to popularize Rudraksha and bring it closer to the people.
Beginning with a supply of Rudraksha beads from Nepal, Indonesia, and India, the Centre is now having the world's largest collection of holy and meditation items used in Vedic pujas, spiritual practices, various rituals and Alternative Healing Therapies.
Rudraksha Ratna Science Therapy® (RRST®) Combinations: Developed by the renowned Rudraksha-Gemstone expert and alternative healer Neeta Singhal, the RRST® is a therapy based on the wearing instructions given in the ancient scriptures such as Shiva Purana.
Wearing Rudraksha Beads in combination with the suitable gemstones (Ratna) generate maximum energy that begins to balance all of your Chakras. You get the best of both; Rudraksha and Gemstones. Best for curing Back Pain, Knee Pain, Body Aches, Headaches, Migraine, Sinus Congestion, Acidity, Diabetes and the like. It gives Personal and Professional Growth, Holistic Health and Happier relationships.
Powerful Vedic (Jyotish) Gemstones: Gemstones and planets are interrelated. It is interesting to know that the Vedic rishis and sages understood well the impact of planets on the mind and the body. Stronger planets send positive energies whereas weaker planets offer challenges and obstacles. We at Rudra Centre recommend the use of correct gemstones in order to enhance the power of benfic planets and minimize the effect of malefic planets.
Yellow Sapphire/Pukhraj (Jupiter): It increases spiritual personal, communication skills, goal achievement, promotion and desirable abundance. It heals Insomnia and Thyroid related issues as it empowers the Vishuddha chakra.
Blue Sapphire/Neelam (Saturn): It enhances intuition, clears confusion, strengthens decision-making ability and helps you attain spiritual enlightenment. It heals a headache and sinus as it empowers the Ajna chakra.
Coral/Moonga (Mars): It gives emotional and physical strengths as well as stability at personal and professional level. It heals piles and bone-related problems as it empowers the Muladhara chakra.
Ruby/Manik (Sun): It gives power, wealth, and keeps your health intact.
Pearl/Moti (Moon): It makes your mind calm, brings boldness against all odds, and creates harmony in relationships. It heals the sexual organs which are ruled by the Swathisthana chakra.
Emerald/Panna (Mercury): It helps you fulfill your wishes, makes you compassionate and strengthens your spiritual side. It heals the heart and lower lungs which are ruled by the Anahata chakra.
Cat's Eye/Lahsuniya (Ketu): It is best for abstract thinking, self-discipline, permanence, fortune, shield against negative forces and eventually enlightenment. It heals bone-related diseases as it works on the Muladhara chakra.
Gomedh/Gomedak (Rahu): It attracts luck, power and divine benedictions. It heals brain related disorders as it governs the Sahasrara chakra.
Diamond/Heera (Venus): Being one of the most precious gems, it endows the wearer with wealth, creativity, higher goals, successful marriage life, and compassion. It heals diabetes and blood pressure as it rules the Heart chakra.
Yantras & Deity Idols: A Yantra represents the sound of Vedic mantras. It carries a spiritual significance and curbs the psychic forces by concentrating it on a specific pattern. All elementary geometrical figures like a straight line, a square, a cross or a triangle etc., symbolize a value corresponding to their basic notions. A Yantra too carries power or energy. Yantras from Rudra Centre are perfectly etched with extensive research based on scriptural reference. A Yantra, when installed in proper direction, generates all the attributes of destroying negative vibes and naturally restores the environment to its natural harmonious state. Similarly, the deity idols carry religious and philosophical significance. Idols from Rudra Centre are made of metals, marbles, and natural gemstones. Puja idols carved in these minerals are additionally potent since they combine the power of the deity along with the power of the planet and the mineral/metal used.
Tatva Vastu Items: We bring you a line of exceptional Tatva Vastu items that are energized to bring into your place the positive cosmic energies. Tatva Vastu by Rudra Centre involves the correct use of energizers placed in the right direction in order to balance the Five Elements of the Universe namely Earth (physical existence), Water (emotions and creativity), Fire (mental power), Air (relationships) and Ether (higher self) in your home or at your workplace. Tatva Vastu items such as Yantras, Pyramids, Gemstones Rocks, Vastu Trees, Vastu Idols, Chimes and the like are based on the Vastu principles. They are highly auspicious and contain the energies of deities, directions, and the cosmic elements. They bring stability, firmness and overall wellbeing.
Puja and Meditation Items: In any Vedic ritual or puja, the most significant aspects are various puja items, ingredients or paraphernalia. Our great range of various sacred items used in Pujas and Homas (Havans) makes Purjas or Havans complete. We offer each and every item used in the puja/havan such as Urli, Puja Thalis, and Puja Pedestals, supari, Bel fruit, ghee, Honey, Akshat (rice grains), Turmeric powder, Sindoor, Ganga Jal and Attar and more.
Kurta and Shawls: We at Rudra Centre offer kurtas and shawls of different sizes and colors based on the Chakra principles. Seven chakras are of seven cosmic colors (Red, Orange, Yellow, Green, Blue, Indigo and Violet). Wearing a kurta of a particular color energizes the Chakra of that color. For instance, Muladhara Chakra is of Red cosmic color. Wearing a kurta of red color has a subtle impact on Muladhara Chakra. We offer kurtas with pajamas and shawls in different designs, sizes, and colors.
Do drop a visit and sight the world's largest collection of spiritual items.
I have received the items. I want to say that I am so much delighted to see Lord ganesha idol. The yantras are perfect and other items of the order. Collector 10 mukhi rudraksha in silver bracelet is absolutely devine and gorgeous. Neeta ji Thank you hand picking these items for me. You are very generous I will definitely will be make more purchases from you in future and if I Happened to be India I would personally visit your store and buy a lot of products from you. I feel completely satisfied with your professional and friendly service. Thanks once again.


Former TD and Workers' Party leader Tomás MacGiolla has died aged 86.
He died at Beaumont Hospital in Dublin this morning following a long illness. He is survived by his wife May.
Mr MacGiolla was a TD for Dublin West from 1982 to 1992. He also served as Lord Mayor of Dublin from 1993 to 1994.
He served as the President of Sinn Féin from 1962 until 1969, when the party split. After that he remained on as the leader of Official Sinn Féin, which later became the Workers' Party.
He retired as leader in 1988 and lost his seat in the Dáil in 1992, following the split of the party and the setting up of Democratic Left.
Taoiseach Brian Cowen described him as a politician of sincerity and strong convictions with a long record of service to the people of Dublin.


2012-13 Heroes and Prospects is a trading card product, with the primary focus on CHL teams. Several young NHL superstars were featured in this product before their NHL Rookie Cards. Such players include Nathan MacKinnon, Jonathon Drouin and Connor McDavid.
The card at the focus of the controversy is the Game Used Memorabilia Patch GOLD version of Justin Bailey, of the Kitchener Rangers in the the OHL. According to the official online checklist provided by ITG, there should be only been 5 copies of this card. 6 copies of this card have been acquired by a collector!
In The Game, often abbreviated to ITG, was founded by Dr. Brian H. Price in 1998. Sometime after May 2014, ownership was transferred to Brian Gray and Leaf Trading Cards in Dallas, Texas. According to a Leaf representative, Dr. Price no longer has any equity in ITG and has no involvement with the day to day operations of the company.
More copies of an In The Game card exists than the stated insert quantity!!


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The code of conduct underpins ZF's principles of business behavior.
Prevent risks jointly with business partners and maintain the trust of customers.


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Investors were in no mood to hear the slightest hint of bad news last week, as the share prices of Wynn Resorts Ltd. (WYNN) and Bally Technologies Inc. (BYI) can attest.
Although Wynn Resorts reported a $65.5 million profit for the fourth fiscal quarter, benefiting from strong high-end play at its hotel/casino in Macau, just the fact that Steve Wynn used the word "caution" in dealing with future Las Vegas business was enough to sour Wall Street.
When the week opened, Wynn Resorts shares were just under $120 each, but by week's end they had fallen to $104.62.
Bally Technology had a blowout quarter with earnings per share reaching $0.42 each, topping the collective wisdom of gaming analysts who had forecasts earnings to be $0.39 per share.
But, naysayers, who misinterpreted an announcement by Harrah's Entertainment Inc. advising that the company had selected International Game Technology (IGT) to handle its server-based requirements, warned that it would shut out Bally Technologies from marketing its gaming machines to Harrah's.
Not true, said Bally Tech.
Then others suggested there might negative implications to a patent lawsuit, filed by IGT against Bally Technology that is scheduled for trial in May.
Again, with rumors flying, BYI shares continued a downward spiral that took it from a high of $52 a few weeks ago to Friday's closing of $39.55 per share.
Among its business highlights for 2007, Wynn Resorts listed the payment of a $6.00 per share distribution to shareholders of record on Dec. 10; successfully opened the Wynn Macau expansion on Dec. 24, 2007, and broke ground on Wynn Diamond suites in Macau.
Net revenues for the fourth quarter were $711.3 million, compared to $563.6 million in the fourth quarter of 2006. For the year, the company had revenues of $2.7 billion, an 87.6% increase over the previous year.
Net income for the fourth quarter reached $65.5 million while the comparable period's net income was a loss of $55.4 million. On an annual basis, exclusive of revenue from the sale of a sub-concession in Macau, diluted net income was $258 million or $2.34 per share.
While speaking to analysts, Steve Wynn, chairman and CEO, said the company had not as yet seen a slowdown in business but suggested "it would be unsophisticated to think that Las Vegas is somehow a magical island unto itself." He advised analysts to "turn on a yellow light" relative to future Las Vegas business.
He emphasized that he catered to the high-end clientele that would be less affected by a market slowdown, an opinion shared by Dennis Forst, analyst at Keybanc Capital Markets.
"I think that people are nervous about the Las Vegas Strip," said Forst, who added that Wynn, Bellagio and the Venetian catered to richer clientele who were "more resistant than others" should a country-wide recession occur.
As for Bally Technology, the company's second quarter was filled with record numbers.
Revenues for the period jumped to $218.9 million compared to last year's $139.7 with net income reaching $24.4 million. In the comparable quarter of 2007, the company reported a net loss of $2.5 million.
Total revenues for the reporting quarter hit $419.7 million compared with last year's $304.7 million.
During the period, the company said it sold 7,144 units with a selling price of $13,147 per unit. In 2007, the company sold 4,672 units with a selling price of $12,620.
For the remainder of the fiscal year, the company raised its projections for earnings per share to be in a range of between $1.62 and $1.87 per share. Revenues are expected to exceed $875 million.
Richard Haddrill, CEO, noted that "Our game performance and continued system success is reflected in record quarterly revenues for each of our game sales, gaming operations and systems business."


text:
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The Treatment of Prisoners under International Law Third Edition
Published April 2011 (Oxford University Press)
ISBN: 9780199693566. Paperback, 752 pages.
This is the third edition of the pioneering work that has become the standard text in the field. The first edition was one of the earliest to establish that the newly-developing international law of human rights could be set down as any other branch of international law. It also incorporates the complementary fields of international humanitarian law and international criminal law, while addressing the problems associated with their interaction with human rights law.
The book is more than a descriptive analysis of the field. It acknowledges areas of unclarity or where developments may be embryonic. Solutions are offered. Recent developments have confirmed the value of solutions proposed in this edition and the previous one.
Central to most of the chapters is the human rights norm of most salience in the treatment of prisoners, namely, the prohibition of torture and cruel, inhuman or degrading treatment or punishment. The early chapters focus on the period of first detention, when detainees are most at risk of having information or confessions, however unreliable, extracted by unlawful means. Voices contemplating the legitimacy of such treatment to combat terrorism have been heard in the wake of the atrocities of 11 September 2001. The book finds that the evidence clearly suggests that the absolute prohibition of such treatment remains firm.
Other chapters deal with problems of poor prison conditions and of certain extraordinary penalties, notably corporal and capital punishment. A chapter explores ethical codes for members of professions capable of inflicting or preventing the prohibited behaviour (police and medical and legal professionals). Chapters are also devoted to the extreme practice of enforced disappearance and the contribution of the new convention on this phenomenon, as well as to extra-legal executions.
Readership: Students of international human rights law, international criminal law, and humanitarian law; scholars and practitioners in these areas.
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Shifting into a new home always bring a mixed form of emotions. Obviously, it would be a joyful moment, but at the same time, potential movers are also concerned about moving household things safely to their new house. Thus, it is a wise decision to hire professional packing companies for shifting and packing in Odisha. These logistic companies are often called as New Gati Packers and Movers. New Gati Packers and Movers in Odisha make the process much faster and quicker with their efficiency. These reputed professional movers and packers will stick to their timelines as well. We operate a vast network of transportation services all over Odisha. Depending upon the size of your inventories, right vehicles are used for transportation.
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These are questions I have been chewing on for some time. One evening, while watering the garden (go figure), the sheer sacrifice of true service overwhelmed me. There among the tomatoes and parsley, I realized that most of my previous attempts at service were much like the garden hose in my hand: I was in control, dictating how, when, and to whom I would serve. With my nifty sprayer, I could even stop the water altogether when I felt like it. The "flow" of Christ's love which I gave to others depended on my mood, the health of my career, and even how much sleep I got the night before. Mine was (and still often is) a self-righteous, self-gratifying service.
In contrast I noticed a soaker hose in the planter across from me. It watered the ground completely indiscriminately. Dozens of holes let the water loose and had no shut-off switch. Life-giving water oozed out all over the place, like it or not! To serve like a soaker hose means to pour out Christ's love from every pore of our beings, not concerning ourselves with the timing, the effect it might have on our productivity, or the worthiness of the recipients. If God has "turned on the water" in our lives, filling us with His life-giving springs, why would we hold them back from anyone? For fear of running out? Doesn't He have an infinite supply of living water?


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Original Title: Membrane and Signal Transduction
Uploaded by P. A. O. ADENIYI
Description: An M. Sc group seminar, University of Ilorin, Nigeria
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MEMBRANE AND SIGNAL TRANSDUCTION
A group seminar presentation
Course code: BCH 625
Course: Membrane Biophysics
Presented by;
OKESINA, Akeem Ayodeji (04/46KA046)
ADENIYI, Philip Adeyemi (05/46KA092)
ADEKOMI Damilare Adedayo (04/48KC194)
POPOOLA Niyi Abdulgafar (02/47KA068)
OYEDEPO Kolade Emmanuel (02/47KA063)
Department of Biochemistry, University of Ilorin,
Ilorin, Nigeria.
Lecturer: Dr. R. Arise
• Introduction to Membrane
• Structure of Membrane
• Function
• Historical Background of Signal Transduction
• Signal Transduction
• Stages of Cell Signalling
The plasma membrane is composed primarily of two types of molecules—
lipids, which are fatty or oily molecules, and proteins. The basic structural
framework of the plasma membrane is formed by two sheets of lipids, each
sheet a single molecule thick. Within this double layer, or bilayer, of lipids, the
protein molecules are embedded. Proteins are responsible for a host of
functions, including transporting substances across the membrane, aiding
communication between cells, and carrying out chemical reactions. In most
cells, the plasma membrane is about 40 percent lipid and 60 percent protein, but
these proportions vary greatly, from as little as 20 percent to as much as 75
percent protein depending on the type of cell (Farabee 2007)
Most of the lipids in the plasma membrane are of a specific type known as
phospholipids. A phospholipid molecule has a head region at one end that is
hydrophilic—it can mix with water. At the other end are two long tails that are
hydrophobic—they do not mix well with water. In the plasma membrane's
bilayer construction, phospholipid molecules are arranged so that their
hydrophilic heads point outward on either side of the membrane, and their
hydrophobic tails point toward each other in the middle of the membrane. This
orientation keeps the hydrophobic tails away from the watery fluids that both
fill and surround living cells. In fact, the plasma membrane stays intact
precisely because the phospholipid molecules strongly resist any change in
configuration that would expose their hydrophobic tails to the watery
environment. (Farabee 2007)
While the phospholipids are held in a bilayer, scientists believe the plasma
membrane as a whole is a fluid structure because phospholipid molecules and
some proteins can move sideways within the membrane. In one second, a single
phospholipid molecule can travel the length of a large bacterial cell. Proteins
drift more slowly through the membrane. With protein molecules scattered
among the phospholipid molecules, the plasma membrane appears to be a
mosaic of phospholipids and proteins. Some of the proteins are found on the
inner or outer surface of the plasma membrane, while others span the membrane
and protrude on either end. Scientists refer to this concept of the plasma
membrane's structure as the fluid mosaic model. (Farabee 2007)
The movement of the phospholipid and protein components through the plasma
membrane permits the membrane to change shape. This flexibility is crucial to
many different types of cells. For example, a single-celled organism known as
an amoeba moves by changing shape, stretching out one part of the cell in the
direction of travel and dragging the rest along behind. Human red blood cells
readily change shape as they squeeze through the body's smallest blood vessels.
(Farabee 2007)
In animal cells, cholesterol also contributes to the fluidity of the plasma
membrane. Cholesterol is a small lipid molecule that nestles among the
hydrophobic tails of the phospholipids in the interior of the membrane. It
prevents phospholipid molecules from packing together too tightly and making
the membrane rigid. It also acts as an "antifreeze" for the plasma membrane,
preventing the membrane from freezing to a jellylike consistency at low
temperatures. Plants and fungi have similar molecules that increase the fluidity
of their plasma membranes. (Farabee 2007)
The lipid and protein molecules that make up the plasma membrane are
manufactured inside the cell and routed to the cell surface. The membrane is a
dynamic structure, with molecules constantly being added to and removed from
the plasma membrane as a cell moves and grows. (Farabee 2007)
(www.lookfordiagnosis.com)
(www.ucl.ac.uk/sjjgsca/cells.)
1. ALLOW TRANSPORT OF MATERIALS ACROSS IT:
The plasma membrane forms an extremely effective seal around the cell. Only a
very few molecules can pass directly through the lipid bilayer to get from one
side of the membrane to the other. Many substances that a cell needs in order to
survive cannot cross the lipid bilayer on their own, including glucose (a sugar
that cells burn for energy), amino acids (the building blocks of proteins), and
ions, such as sodium and potassium. A cell uses two methods to move such
substances from one side of the plasma membrane to another, known as passive
transport and active transport. Both of these processes involve proteins in the
plasma membrane. (Farabee 2007)
Passive transport is accomplished by diffusion, the spontaneous movement of a
substance from a region of greater concentration to a region of lesser
concentration. The difference between the concentration of a substance in two
different areas is known as a concentration gradient. Diffusion moves
molecules down a concentration gradient in a manner that does not require the
cell to expend energy. Water, oxygen, carbon dioxide, and a few other small
molecules diffuse directly across the plasma membrane by passing
between(Farabee 2007)
phospholipid molecules. Substances that cannot pass directly through the
plasma membrane diffuse into or out of cells with the aid of hollow, channel-
like proteins in a process known as facilitated diffusion. These channel proteins
are shaped so that only one substance, or a small group of closely related
substances, can pass through each type of protein. This specificity enables a cell
to control precisely the molecules that travel in and out of the cell. (Farabee
In order to move substances against a concentration gradient—that is, from the
side of the plasma membrane where the concentration of a substance is lower to
the side where it is already higher—a cell must expend energy in a process
known as active transport. Active transport is achieved by membrane proteins
called pumps, which have a docking site that is shaped to fit a specific
substance. These pumps are open on either the inside or the outside of the cell.
When the proper molecule or ion attaches to the docking site, the pump changes
shape so that the docking site moves its opening to the other side of the plasma
membrane, releasing the molecular cargo. Many pumps obtain the energy
necessary to perform this work from adenosine triphosphate (ATP), a molecule
that serves as the main energy currency of living cells. (Farabee 2007)
Two additional transport mechanisms provide pathways for large molecules to
pass in and out of cells. In endocytosis, the plasma membrane folds inward,
forming a pouch that traps molecules. The pouch continues to press inward until
it forms a closed sac that breaks loose from the plasma membrane and sinks into
the cell. The second mechanism, exocytosis, is a reversal of endocytosis. A sac
inside the cell containing proteins and other molecules moves toward the outer
edge of the cell until it touches the plasma membrane. The membrane of the sac
then joins with the plasma membrane, and the contents of the sac are released
from the cell. Most of the proteins released by animal cells, such as hormones
and antibodies, exit the cells where they are made through exocytosis. (Farabee
2. COMMUNICATION BETWEEN CELLS:
In multicellular organisms, the plasma membrane also plays a critical role in
communication between cells. Proteins embedded in the plasma membrane act
as receptors, binding to hormones and other molecules sent as signals from
other cells. In animal cells, certain membrane proteins also act as markers that
help the immune system distinguish the body's own cells from foreign cells.
These marker proteins help trigger the immune reaction that protects humans
and other animals from disease-causing organisms such as bacteria, viruses, and
fungi. These markers also play a role in the rejection of transplanted tissues and
organs. (Farabee 2007)
3.IT ALSO HELP IN HOLDING THE CELLS TOGETHER:
In certain types of cells, the plasma membrane has a wide variety of additional
functions. Some membrane proteins are involved in holding neighbouring cells
together. (Farabee 2007)
HISTORICAL BACKGROUND OF SIGNAL TRANSDUCTION
Cells from nerves, glands, and other tissues communicate with each other by
releasing hormones or other substances that act as chemical signals. In research
conducted in the 1960s and 1970s, Rodbell of the National Institute of
Environmental Health Sciences had demonstrated that cells bind the cellular
molecule guanosine triphosphate (GTP) to their surfaces. This binding activates
the transduction, or conversion, of the exterior message to an internal message
that then triggers a chemical activity inside the cell. (
"signal transduction." A
Dictionary of Biology. 2004. Retrieved July 09, 2010 from Encyclopedia.com: http://www.en
cyclopedia.com/doc/1O6-signaltransduction.html).
Gilman built on Rodbell's work by identifying the protein to which GTP can
bind. Experimenting with mutated leukemia cells, Gilman showed that even
though the cells had all the necessary receptors for transmitting a message from
outside to inside the cell, they were unable to do so. After many years of work,
he and his colleagues isolated a protein that, when added to the cell's membrane,
bound GTP and restored the message-transducing function in the mutated cell.
Because GTP was bound by this protein, Gilman named it the G-protein. Since
Gilman's original discovery, many different types of G-proteins have been
found. The senses of smell, taste, and sight rely on G-proteins to transmit
information along nerve cells. Other G-proteins regulate cell metabolism and
control cell division. (
"signal transduction." A Dictionary of Biology. 2004. Retrieved July 09, 2010 from
Encyclopedia.com: http://www.encyclopedia.com/doc/1O6-signaltransduction.html).
Some diseases can alter the functioning of G-proteins. Cholera, for instance,
produces a toxic enzyme that affects the G-proteins present in the cells of the
intestine, interfering with the ability of the cells to absorb water and salt that the
body needs. Left unchecked, this condition leads to rapid dehydration and death.
G-proteins may also play a part in some symptoms associated with diabetes and
alcoholism. Certain genetic disorders can cause cells to have too many or too
few G-proteins, thereby altering cell function in an adverse way. (
"signal
transduction." A Dictionary of Biology. 2004. Retrieved July 09, 2010 from Encyclopedia.co
m: http://www.encyclopedia.com/doc/1O6-signaltransduction.html).
As well as other honours, Gilman has also received the Albert Lasker Basic
Medical Research Award (1989). Gilman currently chairs the Department of
Pharmacology at the University of Texas Southwest Medical Center in Dallas. (
In the 1940s and 1950s Sutherland studied the hormones epinephrine and
glucagon. Both were known to play a role in releasing glucose (sugar) in the
liver, which the body uses as a source of energy. The exact mechanism of their
action, however, was not understood. In a series of experiments in the 1950s,
Sutherland discovered the molecule cyclic AMP and its role in this process. He
uncovered a chain of chemical reactions that began outside the cell and
continued within it to convert glycogen (stored sugar) to glucose. These
reactions begin when hormones attach, or bind to specific sites on the outside of
a cell membrane. This activates the enzyme (proteins that cause or accelerate
chemical reactions) adenylate cyclase within the cell membrane, which in turn
triggers the release of cyclic AMP within the cell. Cyclic AMP then changes an
inactive enzyme phosphorylase to its active form, which causes glycogen to be
converted to glucose. Sutherland described the hormones in this process as a
first messenger, and cyclic AMP and other intermediates as second messengers.
When he and others found this same reaction in both simple bacteria and
humans, it became clear that this mechanism had been conserved through
evolution over millions of years. Sutherland studied cyclic AMP thoroughly, as
well as another second-messenger molecule known as guanosine
monophosphate (cyclic GMP). Sutherland's discoveries laid the foundation for
the work of today's biochemists and molecular biologists studying signal
transduction (information relayed to the nucleus of the cell via chemical signals,
such as hormones), which has relevance to medical diagnosis, drug
development, and gene therapy. (
Sutherland received many honours for his discoveries. He was elected to the
U.S. National Academy of Sciences in 1966. He won both the Gairdner
International Foundation Award and the Albert Lasker Basic Medical Research
Award in 1970. (
"signal transduction." A Dictionary of Biology. 2004. Retrieved July 09,
2010 from Encyclopedia.com: http://www.encyclopedia.com/doc/1O6-
signaltransduction.html).
Signal transduction originates at the membrane, where the clustering of
signalling proteins is a key step in transmitting a message. Membranes are
difficult to study, and their influence on signalling is still only understood at the
most rudimentary level. Recent advances in the biophysics of membranes,
surveyed in this review, have highlighted a variety of phenomena that are likely
to influence signalling activity, such as local composition heterogeneities and
long-range mechanical effects.Signal transduction'Any
mechanism by which binding of an extracellular signal
molecule to a cell-surface receptor triggers a response
inside the cell.'
The mechanism depends on the type of signal molecule (e.g. hormone,
paracrine, or autocrine signals), but it often involves changes in concentration of
a second messenger (e.g. cyclic AMP, calcium ions) within the cell, which in
turn can affect numerous cell activities. Many receptors are associated with G
proteins, which act to turn signal transduction pathways on and off. Other
important components of signal transduction include protein kinases, which
activate enzymes by transferring a phosphate group from ATP (
Cells usually communicate by releasing chemical messengers targeted for cells
that may not be immediately adjacent. Some messengers travel only short
distances. Such molecules are called local regulators: a substances that
influences cells in vicinity. E.g. animal growth factors, which are compounds
that stimulate nearby target cells to grow and multiply. Numerous cells can
simultaneously receive and respond to the molecules of growth factors produced
by a single cell in their vicinity. This type of local signalling in animals is called
paracrine signalling.(" A Dictionary of Biology. 2004. Retrieved July 09, 2010 from Enc
yclopedia.com: http://www.encyclopedia.com/doc/1O6-signaltransduction.html).
Another specialized type of local signalling occurs between nerve cells. One
nerve cell produces a neurotransmitter, that diffuses (across a synapse) to a
single target cell that is touching the first cell. " (A Dictionary of Biology. 2004. Retri
eved July 09, 2010 from Encyclopedia.com: http://www.encyclopedia.com/doc/1O6-
Both animals and plants use chemicals called hormones for signalling at greater
distances. Cells may also communicate by direct contact. Both animals and
plants have cell junctions that provide cytoplamic continuity between adjacent
cells. Also, animal cells may communicate via direct contact between molecules
on their surfaces. This sort of signalling is important in embryonic development
and in the operation of the immune system. (" A Dictionary of Biology. 2004. Retriev
ed July 09, 2010 from Encyclopedia.com: http://www.encyclopedia.com/doc/1O6-
(" A Dictionary of Biology. 2004. Retrieved July 09, 2010 from Encyclopedia.com: http://ww
w.encyclopedia.com/doc/1O6-signaltransduction.html).
STAGES OF CELL SIGNALLING.
From the perspective of the cell receiving the message, cell signalling can be
divided into three stages: Signal reception, Signal transduction, and Cellular
response. When reception occurs at the plasma membrane, the transduction
stage is usually a pathway of several steps, with each molecule in the pathway
bringing about a change in the next. The last molecule in the pathway triggers
the cell's response.( A Dictionary of Biology. 2004. Retrieved July 09, 2010 from Encyclo
pedia.com: http://www.encyclopedia.com/doc/1O6-signaltransduction.html).
" A Dictionary of Biology. 2004. Retrieved July 09, 2010 from Encyclopedia.com:
http://www.encyclopedia.com/doc/1O6-signaltransduction.html).
SIGNAL RECEPTION AND THE INITIATION OF TRANSDUCTION
A signal molecule binds to a receptor protein, causing the protein to change
shape. A cell targeted by a particular chemical signal has molecules of a
receptor protein that recognizes the signal molecule. The signal molecule is
complementary in shape to a specific site on the receptor and attaches there, like
a key in a lock. The signal molecule behaves as a ligand, the term for a small
molecule that specifically binds to a larger one. Ligand binding causes a
receptor protein to undergo a change in conformation, that is a change in shape.
For many receptors, this shape change directly activates the receptor so that it
can interact with another cellular molecule. For other receptors the immediate
effect of the ligand binding causes the aggregation of two or more receptor
molecules. (Gilman, 1987).
MOST SIGNAL RECEPTORS ARE PLASMA-MEMBRANE PROTEINS.
G-Protein-Linked Receptors. This is a plasma-membrane receptor that works
with the help of a protein called a G protein and another protein, usually an
enzyme. In the absence of the extracellular signal molecule specific for the
receptor, all three proteins are in inactive form. The inactive G protein has a
GDP molecule bound to it. When the signal molecule binds to the receptor
protein, the receptor changes shape in such a way that it binds and activates the
G protein. A molecule of GTP replaces the GDP on the G protein. The active G
protein (moving freely along the membrane) binds to and activates the enzyme,
which triggers the next step in the pathway leading to the cell's response. The G
protein then catalyzes the hydrolysis of its GTP and dissociates from the
enzyme, becoming available for reuse. All three proteins remain attached to the
plasma membrane. (Gilman, 1987).
(Gilman, 1987).
Tyrosine-Kinase Receptors. In the absence of specific signal molecules,
tyrosine-kinase receptors exist as single polypeptides in the plasma membrane.
The extracellular portion of the protein, with the signal-molecule binding site, is
connected by a single transmembrane helix to the protein's cytoplasmic portion.
This part of the protein is responsible for the receptor's tyrosine-kinase activity
and also has a series of tyrosine amino acids. When signals molecules (such as a
growth factor) attach to their binding sites, two polypeptides aggregate, forming
a dimer. Using phosphate groups from ATP, the tyrosin-kinase region of each
polypeptide phosphorylates the tyrosines on the other polypeptide. In other
words, the dimer is both an enzyme and its own substrate. Now fully activated,
the receptor protein can bind specific intracellular proteins, which attach to
particular phosphorylated tyrosines and are themselves activated. Each can then
initiate a signal-transduction pathway leading to a specific cellular response.
Tyrsine-kinase receptors often activate several different signal-tranduction
pathways at once, helping regulate such complicated functions as cell
reproduction (cell divisions). Inappropriate activation of these receptors can
lead to uncontrolled cell growth - cancer. (Li and Hristova 2006)
(Li and Hristova 2006)
Ion-Channel Receptors. Some membrane receptors of chemical signals are
Ligand-gated ion channels. These channels are protein pores in the plasma
membrane that open or close in response to the binding of a chemical signal,
allowing or blocking the flow of specific ions, such as Na+ or Ca2+ into the cell.
Often the change in the concentration of a particular ion inside the cell directly
affects cell function. (Hille, 2001).
(Hille, 2001).
Intracellular Receptors. Not all signal receptors are membrane proteins. Some
are proteins located in the cytoplasm or nucleus of target sells. To reach such a
receptor, a chemical messenger must be able to pass through the target cell's
plasma membrane. A number of important signaling molecules can do just that,
either because they are small enough to pass between the membrane
phospholipids or because they are themselves lipids and therefore soluble in the
membrane. (Albert et al 2002)
Signal-Transduction Pathways
The transduction stage of cell signalling is usually a multistep pathway. One
benefit of such a pathway is signal amplification. If some of the molecules in a
pathway transmit the signal to multiple molecules of the next component in the
series, the result can be a large number of activated molecules at the end of the
pathway. That is a very small number of extracellular signal molecules can
produce a major cellular response. (Schlessinger, 1988)
Pathways relay signals from receptors to cellular responses. Like falling
dominoes, the signal-activated receptor activates another protein, which
activates another molecule, and so on, until the protein that produces the final
cellular response is activated. The molecules that relay a signal from the
receptor to response, sometimes called relay molecules, are mostly proteins.
(Schlessinger, 1988)
Protein phosphorylation, a common mode of regulation in cells, is a major
mechanism of signal transduction. A signalling pathway begins when a signal
molecule binds to a membrane receptor. The receptor then activates a relay
molecule, which activates a protein kinase (1). Active protein kinase 1 transfers
a phosphate from ATP to an inactive molecule of another protein kinase
molecule (2), thus activating this second kinase. In turn, active protein kinase 2
catalyzes the phosphoralation (and activation) of protein kinase 3. Finally,
active protein kinase 3 phosphorylates a protein that brings about the cell's final
response to the signal. Each activated protein kinase molecule is inactivated by
the removal of tha phosphate group by enzymes called phosphatases. This make
the protein kinases available for reuse. (Schlessinger, 1988)
Certain small molecules and ions are key components of signaling pathways
(second messengers). The extra cellular signal molecule that binds to the
membrane receptor is a pathway's "first messenger". Because second
messengers are both small and water-soluble, they can readily spread
throughout the cell by diffusion. Second messangers participate in pathways
initiated by both G-protein-linked receptors and tyrosine-kinase receptors. The
two most widely used second messengers are cyclic AMP and calcium ions,
Ca2+. A large variety of relay proteins are sensitive to the cytosolic
concentration of one or the other of these second messengers. (Hanna et al
Cyclic AMP (cAMP) Cyclic AMP is a component of many G-protein-signaling
pathways. The signal molecule - the "first messanger" - activates a G-protein-
linked receptor, which activates a specific G protein. In turn, the G protein
activates adenylyl cyclase, which catalyzes the conversion of ATP to cAMP.
(Hanna et al 1984).
(Hanna et al 1984)
Calcium Ions and Indositol Triphosphate Calcium ions (Ca2+) are actively
transported out of the cytosol by a variety of protein pumps. Pumps in the
plasma membrane move Ca2+ into the extracellular fluid, and ones in the ER
membrane Ca2+ into the lumen of the ER. Consequently, the Ca2+ consentration
in the cytosol is usually muth lower than in the extracellular fluid and ER.
Additional Ca2+ pumps in the mitochondrial inner membrane operate when the
calcium level in the cytosol rises significantly. These pumps are driven by the
proton-motive force generated across the membrane by mitochondrial electron
transport chains. Calcium ions (Ca2+) and indositol trisphosphate (IP3) functions
as second messengers in many signal-transduction pathways. The process is
initiated by thebinding of a signal molecule to either a G-linjed receptor or a
Tyrosine-kinase receptor. In The following figure the circled numbers trace the
former pathway. 1- Asignal molecule binds to a receptor, leading to 2-
activation of an enzyme celled phospholipase C. 3- This enzyme cleaves a
plasma-membrane phospholipid called PIP2 into DAG and IP3. Both can
function as second messangers. 4- IP#, a small molecule, quickly diffuses
through the cytosol and binds to a ligand-gated calcium channel in the ER
membrane, causing it to open. 5- Calcium ions flow out of the ER (down their
gradient), raising the Ca2+ level in the cytosol. 6- The calcium ions activate the
next protein in one or more signaling pathways, often acting via calmodulin,
aubiquitous Ca2+-binding protein. DAG functions as a second mesanger in still
other pathways. (Hanna et al 1984)
Cellular Response to Signals
Ultimateley, a signal-transduction pathway leads to the regulation of one or
more cellular activities. The regulated activities may occur in the cytoplasm,
such as a rearrangment of the cytoskeleton, the opening or closing of an ion
channel in the plasma membrane, or some aspect of cell metabolism. Many
other signaling pathways ultimately regulate not the activity of an enzyme but
the synthesis of enzymes or other proteins, usually by turing specific genes on
or off. (King et al 2003)
(King et al 2003)
1. (www.lookfordiagnosis.com)
2. (www.ucl.ac.uk/sjjgsca/cells.)
3. Alberts B, Lewis J, Raff M, Roberts K, Walter P (2002). Molecular
biology of the cell (4th ed.). New York: Garland Science. ISBN 0-8153-
3218-1.
4. Farabee M .J 2007 the fluid mosaic model of the structure of cell
membrane.
5. Gilman A.G. (1987). "G Proteins: Transducers of Receptor-Generated
Signals". Annual Review of Biochemistry 56: 615–649.
doi:10.1146/annurev.bi.56.070187.003151. PMID 3113327.
6. Hanna MH, Nowicki JJ and Fatone MA (1984). "Extracellular cyclic
AMP (cAMP) during development of the cellular slime mold
Polysphondylium violaceum: comparison of accumulation in the wild
type and an aggregation-defective mutant". J Bacteriol 157 (2): 345–349.
PMID 215252.
7. Hille B. (2001). Ion channels of excitable membranes. Sunderland, Mass..
ISBN 0878933212.
8. King N, Hittinger CT, Carroll SB (2003). "Evolution of key cell signaling
and adhesion protein families predates animal origins". Science 301
(5631): 361–3. doi:10.1126/science.1083853. PMID 12869759.
9. Li E, Hristova K (2006). "Role of receptor tyrosine kinase
transmembrane domains in cell signaling and human pathologies".
Biochemistry 45 (20): 6241–51. doi:10.1021/bi060609y.
10. Schlessinger, J. (1988). "Signal transduction by allosteric receptor
oligomerization.". Trends Biochem Sci 13 (11): 443–7.
doi:10.1016/0968-0004(88)90219-8. PMID 3075366.
Receptor (Biochemistry)
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The new competition from Roadway Package System looms large. Roadway 1<, cutting labor expenses 20 percent to 30 percent by u ing independent drivers. Because Roadway drivers buy their own trucks, uniforms. and insurance. Roadway is saying moon, that it is using to automate package sorting. "We'll use technology to be the low-cost producer says Bram Johnson. a Roadway vice president.
Roadway says it reduced personnel 25 percent at its five sorting hubs through automation. At its York, Penn ylvarria, hub, for example, a moving belt of tilt trays following instructions from a computer drops packages down a series of chutes.
1. Describe the UPS approach to job design and work measurement.
2. What are the advantages and disadvantages of the UPS approach?
3. What would you do differently? Why?


Product prices and availability are accurate as of 2019-04-20 02:57:59 UTC and are subject to change. Any price and availability information displayed on http://www.amazon.co.uk/ at the time of purchase will apply to the purchase of this product.
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text:
Q: Version and Build numbers not showing up while archiving the build in Xcode I am archiving the build to be submitted to the App Store, but version and build not showing up. I have attached the screenshot for the same. After exporting the .ipa when I am submitting the app via Application Loader I am getting this error. "The Info.plist in the package must contain the CFBundleShortVersionString key." I have already added these details to info.plist file as below.
<key>CFBundleShortVersionString</key>
<string>1.0</string>
<key>CFBundleVersion</key>
<string>1.1</string>

The info.plist file is also in the root folder. I have two separate targets for iPhone and iPad applications.

A: I found one script as below.
git=$(sh /etc/profile; which git)
git_release_version=$("$git" describe --tags --always --abbrev=0)
number_of_commits=$("$git" rev-list master | wc -l | tr -d ' ')
target_plist="$TARGET_BUILD_DIR/$INFOPLIST_PATH"
dsym_plist="$DWARF_DSYM_FOLDER_PATH/$DWARF_DSYM_FILE_NAME/Contents/Info
.plist"

for plist in "$target_plist" "$dsym_plist"; do
if [ -f "$plist" ]; then
/usr/libexec/PlistBuddy -c "Set :CFBundleVersion $number_of_commits"
"$plist"
/usr/libexec/PlistBuddy -c "Set :CFBundleShortVersionString
${git_release_version#*v}" "$plist"
fi
done

I was able to solve the issue after removing this script. This script is for auto updating of version and build number. I do not know why this script was causing the issue.

redpajama_set_name: RedPajamaStackExchange


text:
Chris Brown Pleads Not Guilty And Redmond O'Neal Is Arrested Again.
Dressed in a black suit with four bodyguards and his mother at his side, Chris Brown arrived at the Clara Shortridge Foltz Criminal Justice a little before 3:30p.m.
Inside, Chris Brown pleaded not guilty to charges of assault causing great bodily injury and making criminal threats. Rihanna was not there.
Rihanna's attorney Donald Etra addressed the media following the court appearance saying, "What happened this afternoon is what we fully expected."
"Rihanna's position is the same… she will do everything the law requires her to do," he added.
He continues, "It is not up to her (Rihanna) to decide what kind of deal she wants, that's up to the District Attorney to decide… at this time it is very premature to decide what her position would be."
"She would be pleased if this was over quickly," he said.
If convicted on both counts, Brown faces up to four years and eight months in jail.
Meanwhile…..
Redmond O'Neal is racking up quite a rap sheet for himself.
This time, the son of Farrah Fawcett and Ryan O'Neal, was arrested when he was found to be carrying illegal drugs. His bail has been set at $25,000.
Redmond was stopped at a routine security checkpoint at a detention center in Castaic, CA when he was busted.
This is Redmond's second arrest for drugs in less than a year.
He and his father Ryan O'Neal were arrested last September for possession of meth. After Redmond skipped his arraignment, a bench warrant was issued. In January, Ryan pled guilty.
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WooThemes, the parent company or designer that mooted the concept of WooCommerce, hired designers James Koster and Mike Jolley who developed the ecommerce plug-in. The plug-in became a phenomenon over night and in 3 years there were nearly half a million websites using the plug-in, which provided it a market share of simply except 20% of all ecommerce websites. By the end of 2015, WooCommerce had been actively set up by millions of users and it was powering around 30% of the ecommerce market. While WooCommerce has actually remained one of the free themes and plug-ins of WooThemes, there are countless extensions and add-ons, many of which are superior and thus have to be paid for.
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Memory foam mat offers a great landing place for your feet as you step out of the bathtub or shower.
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© 2018 Muço et al.
To describe the clinical, laboratory, microbiological, and echocardiographic findings in four intravenous drug users with endocarditis hospitalized and followed in our Infectious Disease Service, a tertiary university hospital as well as to determine the efficacy of medical treatment.
From a database of 35 subjects with endocarditis during five years, we made a retrospective analysis of data for four cases between the age of 24-33 years old which were intravenous drug users.
Infective endocarditis was encountered in four drug users with positive blood cultures (Staphylococcus aureus was present in all the cases), vegetations in the tricuspid native valve in ultrasound, high fever (more than 38oC). The four cases were male and the mean age was 29 years (range 24-33 years). Three out of the four cases presented with pulmonary involvement and only one with femoral and popliteal vein thrombosis. Two out of four cases had acute renal and hepatic failure and only one had acute cutaneous vasculitis. Transesophageal Echocardiography (TEE) was also performed in two cases. For all of them medical management consisted of antibiotic therapy and two out of them underwent surgery because of the persistence of valvular vegetations after antibiotic therapy. The prognosis was good with 0% mortality.
Infective endocarditis should be considered in the differential diagnosis of intravenous drug users presenting with various clinical scenarios. Echocardiography remains the main modality and should be used serially to facilitate early diagnosis. The successful management of a complicated case often requires the close cooperation of an infectious disease physician, a cardiologist, an addiction physician and occasionally a cardiac surgeon.
Keywords: Tricuspid valve endocarditis, Intravenous drug users, Staphylococcus aureus, Transthoracic echocardiography.


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text:
@interface DataManagerHandle : NSObject
//判断是否有用户
@property(nonatomic,assign)BOOL isOnline;
//判断是否微博登陆
@property(nonatomic,assign)BOOL isWeibo;
//头像字符串
@property (nonatomic,strong)NSString *messageStr;
//用户 name
@property (nonatomic,strong)NSString *nameStr;

@property(nonatomic,strong)NSString *findname;

@property(nonatomic,strong)NSMutableArray *nowUserFriends;

@property (nonatomic,strong) NSString *lat;
@property (nonatomic,strong) NSString *Long;
@property(nonatomic,strong)NSString *nowCity;

+(DataManagerHandle*)sharedata;

@end


Does Testuff support tests in right to left languages such as Hebrew and Arabic?
Click the Settings link at the top right of the Testuff screen.
Check the Enable right to left languages checkbox.
Enter a project and go to the tests tab.
Edit or create a new test.
Choose a direction for the test via the two direction buttons in the test editor. Note that it controls an entire test to be right to left or left to right.


should this work be reported?
Is it allowed to have 2 supplies to 1 building?
High risk inspection for outbuilding?
Replacing lighting circuits 2.6.3.4 To RCD or not?
Recessed lights in loose fill insulation.


This one-time scholarship benefits students graduating from Davis High School in Yakima, WA. Presently, the award is $1,000.
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Gaelen is graduating from Warden High School on June 8, 2018. This school year he is participating in the running start program at Big Bend Community College, where he has challenged himself by taking upper level classes in math and science. Not only has Gaelen been able to excel academically in this setting, he frequently took on leadership roles at school and in the community. Gaelen enjoyed being team captain of his high school varsity basketball team and volunteering to coach the local 4th grade boys basketball team.
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I graduated from La Salle Catholic High School as salutatorian, and I will be attending Gonzaga University. I was a member of the National Honors Society, La Salle's Campus Minister for ASB, and senior team captain for the tennis team. During the fall and winter of my junior and senior year, I volunteered as an A-Team member (youth group leader) for St. Paul's Spy Edge Youth Group. Also, I participated in my school's retreats as a group leader. At Gonzaga University, I plan to major in Biology or Human Physiology. In the future, I hope to pursue physical therapy with a focus on pediatrics. I am excited to continue my education and Catholic faith at Gonzaga this fall.


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