text:
Big Bang is Mainstream
Thread starter Helio
The theory for the entire cosmos involves not just a little physics, but all of physics both what we know today and what we are still learning.
Many people, including most of my friends (outside this forum), don't really bother learning a great deal about the theory or its history, hence some, perhaps a majority, assume it is not that solid a theory. When you combine the metaphysics of a multiverse concept to explain our universe and its incredibly fine-tuned features, then the general view becomes even more cloudy as to the veracity of BBT.
But since its beginning, BBT (originally the "Primeval Atom" theory) has grown into a very substantially supported theory. The original paper was published in 1927 (Georges Lemaitre). We are less than 6 years away from its 100th anniversary.
Ten decades has brought a great deal more discovery. These discoveries were often sought as a way to falsify the claims within BBT. No theory can be a theory without making testable claims, and any theory of the entire cosmos will come with a great many testable claims. [In contrast, any multiverse "theory" does not qualify as a theory until they can produce a claim that can be tested.]
It's also helpful to understand that no theory can be proven; they can only be falsified. The 2000 year-old Aristotle theory -- advanced by Ptolemy and Thomas Aquinas -- was never proven to be true but, thanks to Galileo and his little telescope, he was able to produce direct evidence that falsified it. [The Jesuits quickly accepted his results as they too used one of his scopes to verify this falsifiation (phases of Venus). At that time, they switched to the Tychonic model for an alternative Geocentric universe.]
IMO, each theory has a degree of strength regarding the claims that come from it. Some theories look strong but fail later. It's not uncommon for a theory to be considered very weak initially. Indeed, Einstein called Lemaitre's theory "abomniable", though he liked the math. Each theory should be understood for its relative strength or strengths. Engineers must have reliable science to build things like bridges and rockets.
So, here are some Big Bang Bullets demonstrating a great deal of direct, and some indirect, evidence supporting it. These many independent lines of evidence produce an amazing confluence of support for the theory.
....> Hubble Constant (redshift) More (http://hyperphysics.phy-astr.gsu.edu/hbase/astro/hubble.html)
....> Einstein's field equations (1916) predicted an expanding (or contracting) universe
....> Time Dilation of Supernova More1 (http://www.berkeley.edu/news/media/releases/99legacy/1-7-1999.html)also More2 (http://www-supernova.lbl.gov/public/)
....> Gamma Ray Bursts
....> The CMBR - Cosmic Microwave Background Radiation. More (http://hyperphysics.phy-astr.gsu.edu/hbase/bkg3k.html)
........> The wavelength (microwave)
........> The Temperature (2.73K). More (http://hypertextbook.com/facts/1997/SilinYang.shtml)
........> The Blackbody Results.
........> The "smoothness" (isotropy)
........> The very small "roughness" (anisotropy) in this radiation. WMAP (http://map.gsfc.nasa.gov/m_mm.html)
........> The angular size of the "hot" spots matching predictions.
........> The power spectrum
....> Distant Cloud temperatures
....> The Element Abundances from Nucleosynthesis.
....> Helium (25%)
....> Deuterium, its relative abundance.
....> The observed Differences in Galaxies between today's and earlier ones.
........> Paucity of distant Barred Spirals.
........> Less organized distant Spirals.
........> No local Quasars.
....> The Age of the Universe in relation to Stellar Compositions.
....> Olber's Paradox resolved. More (http://math.ucr.edu/home/baez/physics/Relativity/GR/olbers.html)
....> Entropy - "The universe is dying" (Helmholtz & 2nd Law).
....> Galactic Superstructure of Super Clusters and Galactic Strands
....> No Ancient Objects older than 15 billion years.
....> The anisotropy found in background neutrino maping, probably.
....> The Lyman Forest morphology
Reactions: TacovilleMC
Atlan0101
The Hubble Constant (redshift) might be evidence of one thing, light doesn't travel faster than the speed of light (and everything it will tell us is, naturally, made by it to be slower than it). What that redshift, though, proves is that the object has traveled faster than the speed of light since the redshift tells us the object is now out of sight in the shadows of the dark universe beyond where the speed of light makes it out to be (where the speed of light puts it in the observable universe (two universes, minimum, the relative at any distance, and the real on the spot, is the very definition of multi-dimensional multiverse)). The light can tell us where the object might have been (providing it has not been broken up, shifted, and reformed), but in no way can it tell us where the object is, or whether it even still exists. Where it is, and if it even still exists, is really the stuff of instantaneity, simultaneity, locality (as in every point of infinity being the exact center of the infinity of universes since there is no other center), and, in general, 'Now (t='0'), everywhere Now (t='0') is, being faster than the speed of light.
We have an abundance of evidence that the 'wild weed'' of the Universe is far more energetic than the structurally temporary perfect lawns we, and therefore the universe, creates. We, and therefore the universe, create structural "entropy", and the return (the re-turn!) is always to energy, to the frontier 'wild' (to endless beginning -- hence no ancient objectivity, most especially including light and gravity waves, still existing older than "15 billion years"). I haven't been a close student of history and the nature of things for more than 67 of 74 years, in addition to being tested and identified a "visual mathematician," for no reason.
According to Chaos Theory there are, at base, two planes, the smooth and the finely lumpy course. With "zoom" they alternate, progressively merging one into the other and separating out one from the other, to infinity. The reduction of the infinity, though, is to the base constant, the base two. The cauldron of quanta chaos that builds up and out unobserved from every local point of universe, collapses and merges into a perfect horizon constant of relative, observed, mural: a one-, at most two-, dimensionally perfect still 'photo' universe horizon, "no chaos . . . a plane smooth as silk," so to speak. The horizon mural's display and physicality: All beginnings, naturally, as a naked singularity of beginning ((Planck) Big Crunch (M) | Big Vacuum (C^2 (c = c . . . squaring)) | (Planck) Big Bang (E)). Not only a look, but a physicality, too, this way local out of that look. It's called "multi-dimensionality."
It's a Multiverse Universe.
Atlan0101, you're covering a lot of ground that gets into the weeds related to BBT. They may be worthy of serious thought, but I'd like to make this thread focused on the strengths presented by those specific arguments (bullets).
Of those presented, can you provide some support reasons for some of them? Do you find some contrary to mainstream science, whether you agree or disagree? Do you disagree with any that are mainstream?
You want to lock this thread strictly to your view of universe and BBT, then say so. You want no denials, infringements, repaintings with twists, or curveballs, then say so. I have my say regarding the horizons as I see them. Do I disagree with the "mainstream"? You must be joking. How many posts have I posted since I've been on this forum? Even Einstein, his friend Godel, and his later equal Hawking, were never in fact "mainstream." They were always venturing outside the limits of the box when they weren't stretching the limits of the box itself. They did their share of writing the book on thinking and drawing outside the box. I won't quote Einstein on those he viewed as "great spirits," what they always faced, face, and will always face from "mainstream" thinking.
Your opening went much farther afield than just BBT. So did I in my coverage.
Atlan0101 said:
You want to lock this thread strictly to your view of universe and BBT, then say so.
Absurd. Are you not familiar with the term "mainstream"? These aren't my views but the position of a vast majority of physicists, astronomers, cosmologists, etc.
I present my limited understanding of their work, not mine. This presentation is for the very pupose of discussing the merits of each claim (bullets).
You want no denials, infringements, repaintings with twists, or curveballs, then say so.
Clearly, I've stated just the opposite.
I have my say regarding the horizons as I see them. Do I disagree with the "mainstream"? You must be joking. How many posts have I posted since I've been on this forum?
Indeed, but scientific claims are falsifiable to qualilfy as actual claims in science. So, is there any one item you can pick out and falsify? The more of these you can send down in flames the more interest you will garner in your ATM views.
Even Einstein, his friend Godel, and his later equal Hawking, were never in fact "mainstream."
So you don't understand what is considered to be "mainstream" at all, obviously. Or do you mean that only some of Einstein's views were not mainstream. SR and GR and most of his other work is definetly mainsteam. Why give a guy a Nobel Prize if it's not worthy?
Also, Einstein waited until he had three independent lines of objective evidence before he introduced GR. The solar eclipse experiement, for example, was one of those three.
They were always venturing outside the limits of the box when they weren't stretching the limits of the box itself. They did their share of writing the book on thinking and drawing outside the box. I won't quote Einstein on those he viewed as "great spirits," what they always faced, face, and will always face from "mainstream" thinking.
That's fair. But Einstein never rejected worthy science. He never said Newton's laws should be rejected.
Because the bullets are mainstream arguments for BBT, my hope is they can be discussed for all of us, espeically me, to better understand the merits (and weaknesses) of each.
TacovilleMC
He was just trying to keep the discussion about what he had presented, not branching into every possibility out there.
1) I am very, very, familiar with the term "mainstream" as it is politically and Orwellian defined now in the 21st century. There is no other definition today. Other than that, I get your point now. You weren't looking to lecture. You are as a student looking to gain deeper knowledge and understanding of the particular items inside their precise boxes of mainstream conventional wisdom. I don't agree with much of the conventional wisdom, as I said, but I can understand what you were looking for. Therefore, since I paint pictures in a more radical-imaginative style, I would be the last person you want to sit at this table because I would be the last you would understand. By the way, your views aren't the views aren't the views of many physicists, astronomers, and cosmologists today, thank goodness. That is why I add the pointers to various articles, illustration, animations, and quotes, to a lot of my posts . . . that apparently you haven't followed in the first place.
2) Einstein's became mainstream sometime after he did the work. And SR and GR were not what he got his "Nobel Prize" for. He never got a Nobel for that work.
3) Of course, he never rejected worthy science. I didn't say he did. I've never rejected it either. Reinterpretation, or interpreting it differently, isn't rejection, however you may believe anything but your interpretations, or so-called "mainstream" interpretations, to be rejection. The science may be objective, but interpreting it is entirely subjective.
4) I've interpreted BBT as I see the BB to be for months and months now. Some here even imagine, some rightly so, they can see my interpretations of Universe (U) and universes (u) even if they don't agree with them. As I said, interpretation is subjective. Interpretation regarding such a vast background as infinite Universe, and the infinity of universes, is really subjective. I leave the objectivity of scientific accumulations to the professionals (as I was a professional on the fringes of science myself at one time). I won't leave subjective interpretation of the objective science to them to try to turn into a tyranny of Orwellian "Big Brother" concrete. Interpretation of the 'Horizon' is a completely different matter. Interpretation of the Universe, the universe, and Multiverse, enters the realm of philosophy ("the philosophy of physics" : "the philosophy of cosmology" : "the philosophy of Cosmopolis" : the "mind's eye" imaginative).
5) The title of this thread is "Big Bang is Mainstream": The sentence opening this thread (all emphasis mine): "The theory for the entire cosmos involves not just a little physics, but all of physics both what we know today and what we are still learning." Bullets: "Hubble Constant (redshift)" : "expanding (or contracting) universe" : "Time dilation" : "The smoothness (isotropy) : The observed Differences in Galaxies between todays and earlier ones" : "Entropy - 'The universe is dying'" : "No Ancient Objects older than 15 billion years". Quite a spread, a very large territory wanted to be covered in the narrowest of ways, but all addressed to some degree in my mostly "out of the box" way. Not what you were looking for; but addressed . . . somewhat. You want only the "mainstream" and degreed professionals, it's quite a big internet and a huge amount of material is there.
I notice one big difference between today and yesteryear. The existence of infinity, and infinities, is gaining a larger acceptance today. There seems to be fewer of the best calling infinity absurd. Recognizing the existence is opening up the universe to much greater possibilities. What is infinity? The definition is widening. One day all of the major "constants" will be defined as "horizon infinites."
Since no one seems interested in debating any of these objective and testable lines of evidence for BBT in the OP (Opening Post), then perhaps we can reference this thread when others wish to imply BBT isn't all that strong of a theory.
If they can falsify some of these bullets, then they would deserve great credit for doing so, and perhaps an ATM theory would deserve greater consideration.
My hope isn't to push these claims but to discuss them so that we can all understand the merits to this remarkable theory. I'm no expert so I do my best learning when discourse takes place, even if I'm the one who must think about my arguments for any one of these claims. Normally, pedagogy forces one to think clearly before teaching.


Last week was Swarthmore Women's Week, a collaboration between the Dean's Office and twelve Swarthmore student groups including the Women's Resource Center (WRC) that focused attention on women's issues from a broad range of perspectives. By pulling together a variety of student groups that don't all necessarily center on women's issues, the week generated an impressive list of events across and even off campus.
The week's events included multiple spoken word workshops with women brought to campus by OASIS, an i20 professor-led panel discussion about transnational women in media, and a movie screening and conversation about the movie Real Women Have Curves organized by ENLACE.
Other events included a women's luncheon at the WRC, a thank-you card-making party for female alumnae, and a workshop on alternatives to sanitary pads and tampons.
The WRC, with the help of Assistant Dean and Gender Education Advisor Karen Henry, spearheaded the Week's planning and served as the umbrella under which the events were organized.
"Our purpose was starting really comprehensive dialogue and bringing lots of groups together on an issue that's really important," Sparks said.
Singh, Sparks, and Durning all expressed their optimism about holding another Swarthmore Women's Week in the future.
Sparks called Women's Week a successful "pilot program" in collaboration between multiple student groups. She also expressed her hope that other groups would pursue organizing similar events in the model of the Swarthmore Women's Week.
"There are so many different awesome groups at Swarthmore. If we collaborate together, the potential is just huge," Sparks said.
Featured image courtesy of Iris Fang '15.


Tripod Revises Web Building Tools - InternetNews.
Online community Tripod, part of the Lycos Network, Monday released Homepage Studio 2.0, the latest upgrade to its suite of homepage building tools and services.
Homepage Studio 2.0 introduces the "One-Minute Page,"a new home page building tool offering instant homepage building tools to members with no knowledge of HTML and the ability incorporate more complex homepage features such as the news, weather and horoscope Info Flashes and search boxes.
The same program allows HTML dabblers to include their own coding in the custom design, and advanced builders can add features such as Smart Ads and participate in a banner exchange program designed to promote member sites and drive more traffic to them. Homepage Studio 2.0 expands Tripod's Info Flashes to include four new categories: lottery results, best-selling books, TV listings and will soon include various metropolitan area traffic reports beyond Boston.
Homepage Studio 2.0 expands builders' privacy options, permitting members to restrict access to a portion of or all their homepages, including chat rooms and message boards.
Community members can now use NameSecure, a domain name registration service, to obtain a personalized domain name for their site.
"Homepage Studio 2.0 is the direct result of great comments and suggestions we received from members," said Tim Breen, Tripod's acting director of product management. "We were pleased that members with all levels of homepage building experience shared their suggestions on how to make homepage building on Tripod a better, more enjoyable experience."
Tripod, a wholly-owned subsidiary of Lycos, Inc., provides homepage-publishing tools to its interactive community, including wide-ranging commerce sites, of more than 3.4 million members.


This entry was posted on Friday, February 14th, 2014 at 11:32 am and is filed under 20 - Come Fly With Me.	You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.


text:
Details for: Reflections on the concept of coherency for a policy on psychoactive substances and beyond
Reflections on the concept of coherency for a policy on psychoactive substances and beyond [publication] /
by Muscat, Richard ; Pike, Brigid ; Conseil de l'Europe. Groupe de coopération en matière de lutte contre l'abus et le trafic illicite des stupéfiants .
Material type: BookPublisher: Strasbourg : Council of Europe, 2012Description: 142 p. ; 24 cm.ISBN: 9789287173454; 9287173451.SAPHIR theme(s): Addictions | Santé publiqueMeSH subject(s): Troubles liés à une substance | Politique sanitaire | Public Policy | Austria | Belgium | Ireland | Israel | Netherlands | Norway | Portugal | SwitzerlandAddiction suisse subject(s): Drogen | Alkohol | Tabak | Politik | Regionaler Vergleich | Schweiz | Europa | IsraelPUBLICATION TYPE SAPHIR: MonographSummary: How are the problems associated with different psychoactive substances, illicit drugs, alcohol and tobacco described? How is the nature of the "problem" shaped by research evidence, media coverage, cultural mores and social, economic and political considerations? To what extent does policy reflect a consistent approach to different psychoactive substances? What objectives do policies on drugs, alcohol and tobacco pursue? Do the structures in place support the co-ordination and/or integration of these policies? The issue of psychoactive substance policies (and beyond) is currently at the forefront of policy making in a number of countries, including those participating in this study, together with the issue of how such a policy may be implemented in a coherent manner. Continuing the work carried out in two previous publications, "From a policy on illegal drugs to a policy on psychoactive substances" (2008) and "Towards an integrated policy on psychoactive substances: a theoretical and empirical analysis" (2010), this work attempts to put into perspective the salient points of what mey be termed a coherent policy on psychoactive substances and beyond. It proposes six indicators, around which the concept of coherency is articulated: conceptualisation, policy context, legislative and regulatory framework, strategic framework, responses/interventions, and structures and resources. The results of this study may be a surprise to some in the field, and tie in with broader efforts by the European Union and the Organisation. [Ed.]
Bibliothèque U1-53 (Browse shelf) Available
How are the problems associated with different psychoactive substances, illicit drugs, alcohol and tobacco described? How is the nature of the "problem" shaped by research evidence, media coverage, cultural mores and social, economic and political considerations? To what extent does policy reflect a consistent approach to different psychoactive substances? What objectives do policies on drugs, alcohol and tobacco pursue? Do the structures in place support the co-ordination and/or integration of these policies? The issue of psychoactive substance policies (and beyond) is currently at the forefront of policy making in a number of countries, including those participating in this study, together with the issue of how such a policy may be implemented in a coherent manner. Continuing the work carried out in two previous publications, "From a policy on illegal drugs to a policy on psychoactive substances" (2008) and "Towards an integrated policy on psychoactive substances: a theoretical and empirical analysis" (2010), this work attempts to put into perspective the salient points of what mey be termed a coherent policy on psychoactive substances and beyond. It proposes six indicators, around which the concept of coherency is articulated: conceptualisation, policy context, legislative and regulatory framework, strategic framework, responses/interventions, and structures and resources. The results of this study may be a surprise to some in the field, and tie in with broader efforts by the European Union and the Organisation. [Ed.]

redpajama_set_name: RedPajamaCommonCrawl


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text:
import {NgModule} from "@angular/core";
import {CommonModule} from "@angular/common";
import {JigsawDemoDescriptionModule} from "app/for-internal/description/demo-description";
import {JigsawButtonModule, JigsawHeaderModule, JigsawStepsModule} from "jigsaw/public_api";
import {JigsawStepGotoDemoComponent} from "./demo.component";

@NgModule({
    imports: [
        JigsawStepsModule,
        CommonModule,
        JigsawDemoDescriptionModule,
        JigsawHeaderModule,
        JigsawButtonModule
    ],
    declarations: [JigsawStepGotoDemoComponent],
    exports: [JigsawStepGotoDemoComponent]
})
export class JigsawStepGotoDemoModule {
}

redpajama_set_name: RedPajamaGithub


I am looking for a decent 3 star hotel in the Wilmington Area. I see that the below hotel in the PRICELINE EXPRESS deal with 10+ user rating listed for $139 per night.
Can you help me ID the hotel. Also any other recommendations for a 3 star Hotel in the are is also welcome.
Below are the Hotel amenities listed.
Please start by concluding your previous Charleston Priceline hotel thread with whatever you ended up doing for that trip. Please remember to follow-up your threads with your wins/decisions as you make them (even if you don't ultimately use PRICELINE / HOTWIRE, cancel the trip, book direct, etc) as this help keep the board better organized and more useful for everyone... as well as being a courtesy to anyone who took the time to help with your travel plans.
... then reply here with the dates of your trip above and we will have a closer look at this offer.
I replied to the Charleston Trip thread. Sorry I forgot to update the thread. My dates for the current trip is 7/26-7/27.
Let us know what you decide and how it goes or if we can be of further help.
I ended up booking the Staybridge Suites Wilmington - Brandywine Valley thru HOTWIRE Hot rate for $120.
Congratulations on your success and thank you for sharing your win with the board.
Can you please add a reply to this thread with the amenities HOTWIRE shows for this property, including any 'accessible' amenities, when viewing this purchase using the MY ACCOUNT >> MY TRIPS link on the top right of their home page... this will enable us to add the amenity set for this property to the Hotwire Hotel List and help others with their own trips in the future.


text:
using System;
using System.Collections.Generic;
using System.Linq;

namespace Autofac.CommandLine
{
    public static class CommandLineExtensions
    {
        public static IEnumerable<string> AsCleanedArgs(this IEnumerable<string> args)
        {
            return args.Skip(1).Where(a => a.StartsWith("-")).Select(a => a.SkipWhile(c => c == '-').Aggregate("", (agg, e) => agg += e)).Where(a => !String.IsNullOrWhiteSpace(a));
        }
    }
}


12/04/2019 - The European Commission has approved, under the EU Merger Regulation, the proposed acquisition by Nidec of Embraco, Whirlpool's refrigeration compressor business. The approval is conditional on compliance with Nidec's commitments.
12/04/2019 - The EU is investing €10 million in technical assistance and capacity building in partner countries in Africa to help improve the business and investment climate, in cooperation with the International Monetary Fund (IMF).
12/04/2019 - The third annual report on the implementation of the Facility shows solid results on EU support to refugees and host communities in Turkey, including: monthly transfer to 1.5 million refugees for their basic needs, 5 million primary health care consultations, access to school for 470,000 children.
European Commission - EUROSTAT Brussels, 12 April 2019 In February 2019 compared with January 2019, seasonally adjusted industrial production fell by 0.2% in the euro area (EA19) and remained unchanged the EU28, according to estimates from Eurostat, the statistical office of the European Union.
11/04/2019 - The European Union and its Member States continued to be the world's leading provider of official development assistance in 2018 and stepped up their efforts directed at developing countries.


text:
Q: Cocoapods: Unable to find a specification for `Firebase/Core` I have this in podfile:
pod 'Firebase/Core'
pod 'Firebase/Messaging'

but getting this error:

[!] Unable to find a specification for Firebase/Core

i tried with pod 'Firebase' still can't find it.
Podfile:
# Uncomment this line to define a global platform for your project
# platform :ios, '8.0'
# Uncomment this line if you're using Swift
use_frameworks!

target 'caffetouch manager' do
    pod 'Firebase/Core'
    pod 'Firebase/Messaging'
    pod 'Alamofire', '~> 4.0.0'
    pod 'AlamofireNetworkActivityIndicator', '~> 2.0.1'
    pod 'IQKeyboardManagerSwift', '~> 4.0.6'
    pod 'MZFormSheetPresentationController', '~> 2.4.2'
    pod 'Kingfisher', '~> 3.1.3'
    pod "GMStepper"
    pod 'DKImagePickerController', '~> 3.4.0'
    pod 'Siren', '~> 1.0.2'
    pod 'Eureka', '~> 2.0.0-beta.1'
    pod 'SwiftyJSON'
    pod 'ObjectMapper', '~> 2.1'
    pod 'NVActivityIndicatorView'
    pod 'SwiftDate', '~> 4.0.5'
    pod 'SimpleAlert' '~> 2.0.1'

    pod 'BTNavigationDropdownMenu', :git => 'https://github.com/PhamBaTho/BTNavigationDropdownMenu.git', :branch => 'swift-3.0'
    pod 'ENSwiftSideMenu', :git => 'https://github.com/evnaz/ENSwiftSideMenu.git', :branch => 'master'
    pod 'SkyFloatingLabelTextField', git: "https://github.com/MLSDev/SkyFloatingLabelTextField.git", branch: "swift3"
end

post_install do |installer|
  installer.pods_project.targets.each do |target|
    target.build_configurations.each do |config|
      config.build_settings['SWIFT_VERSION'] = '3.0'
    end
  end
end

A: Try to update pod repository
pod repo update

If doesn't help show log from
pod install --verbose

Edit:
try to add
source 'https://github.com/CocoaPods/Specs.git'

to your Podfile. If doesn't help probably there is a problem with your local pod repo. You can fix this using:
pod repo remove master
pod setup
pod install

A: try below commands:
pod repo remove master
pod repo update
pod install --verbose

A: try to delete the file podfile.lock
it helps with issue:

[!] CocoaPods could not find compatible versions for pod
  "Firebase/Core":    In snapshot (Podfile.lock):
      Firebase/Core (= 4.8.1)

A: Check if your podfile looks like this and then execute pod install:
platform :ios, '10.0'
use_frameworks!

target '<YOUR APP TARGET>' do

  # Firebase
  pod 'Firebase'
  pod 'Firebase/Core'
  pod 'Firebase/Messaging'

end

post_install do |installer|
  installer.pods_project.targets.each do |target|
    target.build_configurations.each do |config|
      config.build_settings['SWIFT_VERSION'] = '3.0'
    end
  end
end

A: This worked for me by updating cocoapods and my pod repo:
sudo gem install cocoapods
pod repo update

A: None of the approaches mentioned worked for me. Here is how I made it to work, however:

*

*Comment out all of your pods in your Podfile.

*Comment them back in
one-by-one and run pod install after each

*Clean and run

I hope it will help somebody.

A: If it still doesn't work, remove cocoapods directory rm -rf ~/.cocoapods and re-setup cocoapods using pod setup
Hope that helps

A: had the same problem.
what really worked for me was gem uninstall cocoapods where I found that I had 11 (!) cocoapods versions. I chose to uninstall all and then gem install cocoapods:1.4.0
All good now.

A: Hello I just delete this row
if you are using unity and try to run for ios
source 'https://github.com/CocoaPods/Specs.git'

redpajama_set_name: RedPajamaStackExchange


The Top Five Nominees From Last Week's Nominations Are Listed In This Poll.
Winner To Receive Stainless Steel Drink Shaker Engraved With Their Name And Title.
An interesting note- in the nominations only one vote separated the 5th and 6th place nominee. Had only two more of their patrons voted, the nominations could have swung a different way.
Lesson being vote for your favorite, it could be the difference between winning and losing. Only one vote per person.
Subscribe To www.thehomiecast.com here to receive notification of the winner.
This entry was posted in Poll and tagged Best Partender Poll, Gloucester's Best Bartender. Bookmark the permalink.


text:
Florida Governor Wants To Spend $100 Million On Travel Advertising
Jason Garcia, Orlando Sentinel
Flanked by Central Florida tourism executives, Gov. Rick Scott on Friday called on state lawmakers to spend $100 million next year on travel advertising.
The tourism industry subsidy would be the largest in state history and a nearly 60 percent increase from the $63.5 million Florida is spending this fiscal year on Visit Florida, the state's travel-marketing agency.
Scott, who has set a goal of drawing 100 million tourists to Florida annually, framed the issue as one of job creation, as money spent by travelers spurs demand for housekeepers, waiters, ride operators, cab drivers and other tourism jobs.
"It's $100 million to get more tourists and more jobs for Florida families," the Republican governor said during a news conference at Orlando International Airport, where he was joined by representatives from Universal Orlando, Walt Disney World and SeaWorld Orlando, and a host of smaller attractions.
Scott said Visit Florida's budget boost would allow the agency to extend its domestic advertising year-round, expand international marketing programs and incentivize more non-stop air service to Florida airports.
In a brief session with reporters following the announcement, Scott was asked whether he was paying attention to the Orlando-Orange County Expressway Authority where two of his board appointees — Scott Batterson and Marco Pena — have been accused of breaking the state's public-meeting laws in order to discuss the potential firing of the agency's former director, Max Crumit, who subsequently resigned.
Batterson and Pena — along with board member Noranne Downs, a Florida Department of Transportation official who also ultimately answers to Scott — then won a 3-2 vote this week to give the minimum $175,000-a-year job to outgoing state Rep. Steve Precourt, R-Orlando.
The two board members to vote against Precourt's hiring, Orange County Mayor Teresa Jacobs and authority Chairman Walter Ketcham, have said the maneuvering smacks of political favoritism. And State Attorney Jeff Ashton has launched an investigation.
Scott would not say whether he intends to get involved.
"We'll see what happens with the investigation," he said.
Staff writer Dan Tracy contributed to this report. jrgarcia@tribune.com or 407-420-5414 ___
(c)2014 The Orlando Sentinel (Orlando, Fla.)
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Tags: florida, marketing, tourism


That's how Brenden Aaronson responds when I ask him what stood out to him about his play when Bethlehem Steel walloped Atlanta United II 4-1 last Sunday. I had already asked Aaronson about the goal he scored ("I kind of readjusted my body and put it in with my left foot") and the one he set up ("Chambo [Steel captain James Chamberlain] and I have a pretty good connection") so I'm looking for something small that I might have missed but that the 17-year old, who was named to the USL Team of the Week, noticed.
His response is not cocky; it's honest, and perhaps a little rueful. As much as he did to tear apart Atlanta, Aaronson put himself in positions to do even more.
Perhaps even more impressive: the teenager was a key part of the early high press that tore apart Atlanta's buildup play. As part of the Atlanta United ecosystem, ATL II desperately wants to play out of the back. But Steel's front three — Aidan Apodaca, Union winger Marcus Epps, and Chris Nanco — were too fast and organized for the visitors and continually pressed the back line effectively. As the attacking midfielder, Aaronson was responsible for reading the first wave of pressure and stepping in to ensure Atlanta could not play around it with a simple pass.
Combine the beautiful skill — Aaronson can already weight a throughball like a seasoned playmaker — and the high workrate, add in a lithe frame and positional intelligence? Quite a player by any standard. But that last sentence stands out: It just has to be that way.
It is not a thoughtless phrase, a way to move past an idea without critically evaluating it. Instead, Aaronson recognizes that for the Union's system to work, pressing must be a coherent team activity. When the front three close down the ball and the nearest passing options, that often leaves another more dangerous lane. And the Union U19 player needs to be ready to close down that pass or the man who receives it. It really does need to be that way for the system to work.
A team that plays the Union's style needs to have that trust in their creative hub to function. As Aaronson himself might say, for he and his club to succeed it just has to be that way.


text:
Coast Guard rescues 3 stranded hikers from cliffs in 2 states
U.S. Coast Guard sent this bulletin at 08/06/2019 06:31 PM EDT
U.S. Coast Guard 13th District Pacific Northwest
Contact: 13th District Public Affairs
13th District online newsroom
Editors' Note: Image above left depicts rescued hikers from Cascade Head, Oregon; image to right is hoist video of rescued hiker in La Push, Washington. Click on images to download high resolution version.
SEATTLE — Coast Guard crews rescued three stranded hikers Monday night in two separate cases in Oregon and Washington.
During the first rescue, watchstanders at Coast Guard Sector North Bend, Oregon, command center were notified by the Lincoln County Sheriff's Department at approximately 9:15 p.m. that two men were stranded on rocks about 40 feet above the shore near Cascade Head.
The command center diverted an aircrew from Coast Guard Air Facility North Bend to assist local authorities. At 10 p.m., the aircrew arrived on scene and deployed their rescue swimmer to attend to the hikers.
At 10:20 p.m. the aircrew hoisted the hikers into the helicopter and transported them to Newport Airport. Both men reported no medical concerns.
"Our crew overcame a challenging 100-foot hoist in low illumination to return both men safely to their families," said Lt. Ryan Brown, MH-65 pilot for Air Facility North Bend.
During the second rescue, watchstanders at Coast Guard Sector Puget Sound command center received a report from a good Samaritan, who heard a female hiker calling out for help near Third Beach in La Push, Washington.
The hiker became stranded on a rock after a tidal change submerged the hiker's way out.
At 9:15 p.m., Coast Guard Air Station Port Angeles diverted an MH-65 Dolphin rescue helicopter crew already in the air returning from another agency assist search and rescue case of a missing paddle boarder on Mountain Lake, Orcas Island. The rescue helicopter crew conducted a brief landing and refuel at Air Station Port Angeles prior to their transit through foggy weather conditions en route to the stranded hiker.
At approximately 9:30 p.m. Coast Guard Station Quilayute River launched a 47-foot Motor Life Boat crew to help guide the helicopter to the hiker. When the boatcrew arrived on scene, they confirmed the hiker was stranded and close to the cliffs.
The MH-65 Dolphin helicopter crew arrived on scene at 10:45 p.m. and lowered a rescue swimmer. The aircrew hoisted and transported the hiker to Fairchild Airport, where Sector Puget Sound coordinated transportation of the stranded hiker with Clallam County back to their camp site in Forks, Washington.
The female hiker reported no injuries.
"We managed very challenging weather conditions and darkness to get our rescue swimmer safely to the hiker stranded on a rocky outcropping," said Lt. Darin Coleman, MH-65 pilot for Air Station Port Angeles. "We had great coordination and communication with the Motor Life Boat crew to get the hiker safely to shore."
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Recharged je remixovaná deska americké skupiny Linkin Park, vydaná 28. října 2013. Její hlavní písní je píseň A light that never comes kterou skupina nazpívala společně se Stevem Aokim.

Seznam skladeb
 Linkin Park - A LIGHT THAT NEVER COMES (Linkin Park x Steve Aoki)
 Linkin Park - CASTLE OF GLASS (M. Shinoda Remix)
 Linkin Park - LOST IN THE ECHO (KillSonik Remix)
 Linkin Park - VICTIMIZED (M. Shinoda Remix)
 Linkin Park - I'LL BE GONE (Schoolboy Remix)
 Linkin Park - LIES GREED MISERY (Dirtyphonics Remix)
 Linkin Park - ROADS UNTRAVELED (Rad Omen Remix feat. Bun B)
 Linkin Park - POWERLESS (Enferno Remix)
 Linkin Park - BURN IT DOWN (Tom Swoon Remix)
 Linkin Park - UNTIL IT BREAKS (Datsik Remix)
 Linkin Park - SKIN TO BONE (Nick Catchdubs Remix feat. Cody B. Ware and Ryu)
 Linkin Park - I'LL BE GONE (Vice Remix feat. Pusha T)
 Linkin Park - UNTIL IT BREAKS (Money Mark Headphone Remix)
 Linkin Park - A LIGHT THAT NEVER COMES (Rick Rubin Reboot)
 Linkin Park - BURN IT DOWN (Paul Van Dyk Remix) (Bonus Track)

Alba Linkin Park
Alba z roku 2013
Alba Warner Bros. Records

redpajama_set_name: RedPajamaWikipedia


If your work takes you different places each day then you are just one of the few lucky people out there who don't have to sit in the same dull office every day. Gardening & landscaping is one of the most adventurous businesses out there because you get to see different places and meet new people each and every day. On top of that, you can also personally witness how your handwork is changing the world one garden at a time and you get to spend all your time in the glorious sunshine and in beautiful gardens.
The better gear you have, the wider your services can expand which is why it is so important to invest in good quality equipment. The better your equipment, the easier your job will become and the longer your equipment will last.
Ladder – A lightweight tripod ladder is a must for any garden landscaper because you can trim hedges and trees and be completely safe when you are doing these risky jobs because the tripod ladders are much more stable and requires less space to setup. These light ladders can easily be added onto the side of your trailer or on top of a van and you can be on your way to any location instantly.
Lawnmower – Of course you need a lawnmower when you have a gardening business. It's probably the one piece of equipment that you are going to use in every single garden. Luckily some of the lawnmowers are incredibly advanced and you can even invest in a ride able mower when you land a contract with a golf course.
Trimmer – Hedge trimming is vital for rounding your hard work off. No garden ever looks tidy when the final touches haven't been done.
Protective gear – Some of the gear you use can be dangerous. You can easily cut yourself while sawing off some branches. A basic overall and some safety shoos is the minimal for when you are doing hand labor.
Chainsaw – A chainsaw can expand your services a lot because you can provide tree removal or trimming services since most people cannot remove trees by themselves.
Trailer – A trailer is a must for hauling all of your stuff from one location to another and you can add some waste removal services to your company.
Hand saw – Some of the branches are simply too thick for normal clippers and this is exactly where you need a good quality hand saw that you can use along with your ladder.
Basic garden gear – Your garden services would never be complete without the basics such as shovels and rakes.
It can be tough to be a gardener when your workers don't have the right knowledge on gardening to tell weeds from plants. You should try to educate them as best you can so they can continue working without constant supervision.
As a garden and landscaper you can also add some services such as pool installation and cleaning or perhaps water feature setups. The possibilities are endless for a unique company like yours and you will have the time of your life if you keep expanding your services.


Montagna Natural is a hand scraped wood plank on a porcelain body. The porcelain body allows you to have the look of wood with the durability of porcelain. Unlike conventional wood planks, these porcelain wood planks are not affected by seasonal changes, where the joints expand and contract. Long gone are the days of waxing, staining and sanding.
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Buy online MARAZZI Montagna Natural 6 in. x 24 in Glazed Porcelain Floor and Wall Tile (14.53 sq. ft. / case) ULG3, leave review and share Your friends.


text:
Q: How to remove the timezone from yfinance data? I grab data with yfinance package. I convert it into a panda dataframe.
However, I am unable to save the dataframe to excel file.

ValueError: Excel does not support datetimes with timezones. Please
ensure that datetimes are timezone unaware before writing to Excel.

This is how the dataframe looks like. It should be 8 columns. Spyder says it has 7 columns.

Below is my codes:
import yfinance as yf
import pandas as pd

stock = yf.Ticker("BABA")
# get stock info
stock.info

# get historical market data
hist = stock.history(start="2021-03-25",end="2021-05-20",interval="15m")
hist = pd.DataFrame(hist)

# pd.to_datetime(hist['Datetime'])
# hist['Datetime'].dt.tz_localize(None)

hist.to_excel(excel_writer= "D:/data/python projects/stock_BABA2.xlsx")

A: You can remove the time zone information of DatetimeIndex using DatetimeIndex.tz_localize() , as follows:
hist.index = hist.index.tz_localize(None)

A: You can convert time zones using tz_convert(), in your situation it should work with:
hist.index = hist.index.tz_convert(None)


text:
HomeTinton Falls - Eatontown SunTinton Falls - Eatontown SportsCroddick's OT goal lifts Bulldogs over Eagles in Dowd Cup final
Croddick's OT goal lifts Bulldogs over Eagles in Dowd Cup final
By STEVEN BASSIN, Staff Writer
Rumson-Fair Haven Regional High School ice hockey player Andrew Croddick celebrates helping the Bulldogs win the Dowd Cup against Middletown South on Feb. 17 in Wall. Croddick scored the game-winning goal in overtime to help Rumson-Fair Haven defeat Middletown South 2-1.
Two years ago, the Rumson-Fair Haven Regional High School ice hockey team defeated Middletown South High School, 9-3, to win the Shore Conference Tournament Handchen Cup bracket.
On Feb. 17, the Bulldogs and the Eagles faced off at the Jersey Shore Arena in Wall Township with the Shore Conference Tournament Dowd Cup bracket championship on the line.
The Handchen Cup has been in place since 1985 and is named for the late Hank Handchen, who was the first athletic director at Brick Township High School in 1958 and later served on the New Jersey High School Ice Hockey Committee.
The Dowd Cup became part of the Shore Conference Tournament in 2002 and is named for Brick Township High School graduate and former NHL player Jim Dowd.
Since 2008, the Dowd Cup and the Handchen Cup have been part of the Shore Conference Tournament. The top 16 teams in the conference qualify for the tournament and are divided into two eight-team brackets.
In the 2022 Dowd Cup final, sophomore Andrew Croddick became the hero for Rumson-Fair Haven as he scored in sudden death overtime to propel the Bulldogs to a 2-1 victory over Middletown South.
FINAL: GAME-WINNER by Andy Croddick in OT leads RFH (@RFHhockey) to a 2-1 victory over Middletown South to win the Dowd Cup! CC: @central_jersey @rfh_ad @RFH_Regional @rfhdawgpound22 #NJHockey 🏒 pic.twitter.com/kOcg4xIKv4
— Steven Bassin (@SBassin_Sports) February 18, 2022
"It feels amazing," Croddick said after scoring the game-winning goal. "We have a good team this year. Last year, we didn't get to have a Shore Conference Tournament (due to the coronavirus pandemic), so we had to win it this year."
Two championships in three years symbolizes the success third-year coach Eric Zullo and the Bulldogs have had on the ice.
Rumson-Fair Haven is 38-7-7 since Zullo took the reins of the program.
"It's a program victory and it means a lot to us," Zullo said about winning the Dowd Cup. "We went 10-0-2 last year and there was nothing for us to win and we were so good. To win this (championship) means the world to our seniors and the guys last year who are no longer with us."
In the Dowd Cup final, Rumson-Fair Haven (12-4-2) took a 1-0 lead with under 1:00 to play in the first period.
Senior Connor Spagnuola won a face-off in the attacking zone and barreled his way toward the net where he poked a shot that hit the stick of a Middletown South player. The puck ricocheted past goalie Jack Collings and into the back of the net.
END OF 1st Period! @RFHhockey takes a 1-0 with 56.5 seconds left in the 1st period. Connor Spagnuola awarded the goal for the Bulldogs after winning the face off & fighting his way to the net. CC: @central_jersey @rfh_ad @rfhdawgpound22 #NJHockey 🏒 pic.twitter.com/TE4AB9tt88
Rumson-Fair Haven held the lead until the Eagles scored with 3:19 to play in the second period. Sophomore Justin Ferlanti scored with an assist from Brandon Gronau to tie the score at 1-1.
Rumson-Fair Haven junior goalie Ryan Kuras did not let the goal affect his play and he did not allow another puck to get past him. Kuras finished the game with 22 saves to collect his ninth win in net.
"Words can't even describe how amazing it feels right now," Kuras said after the victory. "It was a great all-around team game. I thought my defensemen did a good job of letting me see the puck and that helped me save those outside shots."
Neither team scored in the third period. The Bulldogs had a chance with :15 to play, but Collings denied Croddick's attempt to win the game by coming up with a save that sent the teams to overtime.
15.2 seconds left in regulation. Game tied 1-1. RFH just misses a chance to win the game here. #NJHockey 🏒 pic.twitter.com/W46bXfrSiL
Collings finished the game with 37 saves.
In overtime, the Eagles were whistled for a penalty. Six minutes into the period, with the Bulldogs on a power play, Croddick picked up a loose puck behind the Middletown South net, circled to the front and found an open lane to flick a shot over Collings' stick and into the net to secure the 2-1 victory and the Dowd Cup. It was Croddick's first game-winning goal.
"I just went to the net and wished for the best," Croddick said. "We came out strong in overtime. I just shoved the puck and it went over the goalie and into the net. It felt amazing. Since I was little, I always dreamed of playing high school hockey and winning a conference championship someday."
Croddick remembers watching his brother, Ryan, help the Bulldogs win the Handchen Cup two years ago.
Rumson-Fair Haven is the No. 2 seed in the NJSIAA Public B state tournament and will host No. 15 seed Ramsey in the first round on Feb. 24.
The Rumson-Fair Haven Regional High School ice hockey team celebrates defeating Middletown South 2-1 to win the Dowd Cup on Feb. 17 in Wall.
Rumson-Fair Haven Regional High School ice hockey player Nikolas Doumas dribbles the puck into the Middletown South zone during the Dowd Cup final on Feb. 17 in Wall. Rumson-Fair Haven won 2-1.
Rumson-Fair Haven Regional High School ice hockey player Ben Turoczi rips a shot towards the net during the Dowd Cup final against Middletown South on Feb. 17 in Wall.
Rumson-Fair Haven Regional High School ice hockey player Sal Iorio controls the puck up the boards against Middletown South's Justin Ferlanti during the Dowd Cup final on Feb. 17 in Wall. Rumson-Fair Haven won 2-1 in overtime.
Rumson-Fair Haven Regional High School ice hockey player Beau Kemler checks Middletown South's Owen Oglevee against the boards during the Dowd Cup final on Feb. 17 in Wall. Rumson-Fair Haven won 2-1 in overtime.
Rumson-Fair Haven Regional High School ice hockey player Charlie Tallman surveys the ice from behind the Middletown South net during the Dowd Cup final on Feb. 17 in Wall.
Dowd Cup
Rumson Fair-Haven Regional High School
Shore Conference Tournament
Previous articleFreehold Township H.S. teacher receives emerging leader award
Next articleWhat to Watch
STEVEN BASSIN, Staff Writerhttps://centraljersey.com/


text:
Medical Encyclopedia
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Search MedlinePlus
Genetics →
Genes →
MECP2 gene
URL of this page: https://medlineplus.gov/genetics/gene/mecp2/
methyl-CpG binding protein 2
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Normal Function
The MECP2 gene provides instructions for making a protein called MeCP2. This protein helps regulate gene activity (expression) by modifying chromatin, the complex of DNA and protein that packages DNA into chromosomes. The MeCP2 protein is present in cells throughout the body, although it is particularly abundant in brain cells.
In the brain, the MeCP2 protein is important for the function of several types of cells, including nerve cells (neurons). The protein likely plays a role in maintaining connections (synapses) between neurons, where cell-to-cell communication occurs. Many of the genes that are known to be regulated by the MeCP2 protein play a role in normal brain function, particularly the maintenance of synapses.
Researchers believe that the MeCP2 protein may also be involved in processing molecules called messenger RNA (mRNA), which serve as genetic blueprints for making proteins. By cutting and rearranging mRNA molecules in different ways, the MeCP2 protein controls the production of different versions of certain proteins. This process is known as alternative splicing. In the brain, the alternative splicing of proteins is critical for normal communication between neurons and may also be necessary for the function of other types of brain cells.
Health Conditions Related to Genetic Changes
MECP2 duplication syndrome
An extra copy (duplication) of the MECP2 gene in each cell causes MECP2 duplication syndrome, a condition characterized by intellectual disability, delayed development, and seizures. This condition affects males more often than females. When females are affected, they tend to have milder features. The duplication occurs on the long (q) arm of the X chromosome and includes the MECP2 gene; other genes may also be involved, depending on the size of the duplicated segment. The size of the duplication varies from 100,000 to a few million DNA building blocks (base pairs).
Duplication of the MECP2 gene leads to the production of extra MeCP2 protein and an increase in protein function. The resulting changes in gene regulation and protein production in the brain lead to abnormal neuronal function. These neuronal changes disrupt normal brain activity, causing the signs and symptoms of MECP2 duplication syndrome.
More About This Health Condition
MECP2-related severe neonatal encephalopathy
At least 19 mutations in the MECP2 gene cause MECP2-related severe neonatal encephalopathy. This condition almost exclusively affects males and is characterized by small head size (microcephaly), movement disorders, breathing problems, and seizures. Many of the MECP2 gene mutations that cause this condition in males cause a similar disorder called Rett syndrome (described below) in females. Most of these mutations change single base pairs, insert or delete base pairs in the gene, or change how protein is produced from the gene. These changes in DNA alter the structure of the MeCP2 protein or reduce the amount of protein that is produced. As a result, cells do not have enough MeCP2 protein to bind to DNA and regulate other genes. A shortage of MeCP2 alters the activity of genes that are normally controlled by this protein. Mutations in the MECP2 gene may also disrupt alternative splicing of proteins critical for communication between neurons. Although these defects disrupt normal brain development, it remains unclear how MECP2 gene mutations lead to the signs and symptoms of MECP2-related severe neonatal encephalopathy.
PPM-X syndrome
Mutations in the MECP2 gene have been found to cause PPM-X syndrome. This disorder is characterized by mild to severe intellectual disability, bipolar disorder, and a pattern of movement abnormalities known as parkinsonism. This condition affects males more often than females; when females are affected, they tend to have only mild intellectual disability.
Eight particular mutations are responsible for approximately half of all cases of PPM-X syndrome. These mutations either change single protein building blocks (amino acids) in the MeCP2 protein or create a premature stop signal in the instructions for making the protein. Mutations that cause PPM-X syndrome lead to the production of a MeCP2 protein that cannot properly interact with DNA or other proteins and so cannot control the expression of genes. It is unclear how MECP2 gene mutations lead to the signs and symptoms of PPM-X syndrome, but misregulation of genes in the brain likely play a role in the development of intellectual disability and movement and mood disorders in affected individuals.
More than 620 mutations in the MECP2 gene have been identified in females with Rett syndrome, a brain disorder that causes problems with communication, learning, and coordination. These mutations include changes in single base pairs, insertions or deletions of DNA in the gene, and changes that affect how the information carried by the gene is used to produce proteins. MECP2 gene mutations alter the structure of the MeCP2 protein or reduce the amount of protein that is produced. The resulting shortage of functional MeCP2 likely impairs the regulation of gene expression in brain cells and may also disrupt alternative splicing of proteins critical for communication between neurons. Studies suggest that these changes may reduce the activity of certain neurons and impact their ability to communicate with one another. It is unclear how these changes lead to the specific features of Rett syndrome.
MedlinePlus Genetics provides information about Autism spectrum disorder
Mutations in the MECP2 gene have also been identified in people with several other disorders that affect the brain. For example, MECP2 gene mutations are associated with some cases of moderate to severe X-linked intellectual disability without other features of the syndromes described above. In addition, several people with both the features of Rett syndrome and signs and symptoms similar to Angelman syndrome (a condition characterized by intellectual disability, problems with movement, and inappropriate laughter and excitability) have mutations in the MECP2 gene. MECP2 gene mutations or changes in the gene's activity have been reported in some cases of autism spectrum disorder, which affects communication and social interaction.
Other Names for This Gene
MeCP2 protein
MECP2_HUMAN
methyl CpG binding protein 2
methyl CpG binding protein 2 (Rett syndrome)
MRX16
PPMX
Additional Information & Resources
Tests Listed in the Genetic Testing Registry
Tests of MECP2
Scientific Articles on PubMed
Catalog of Genes and Diseases from OMIM
MENTAL RETARDATION, X-LINKED, SYNDROMIC 13
METHYL-CpG-BINDING PROTEIN 2
Gene and Variant Databases
Adkins NL, Georgel PT. MeCP2: structure and function. Biochem Cell Biol. 2011 Feb;89(1):1-11. doi: 10.1139/O10-112. Citation on PubMed
Amir RE, Van den Veyver IB, Wan M, Tran CQ, Francke U, Zoghbi HY. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet. 1999 Oct;23(2):185-8. doi: 10.1038/13810. Citation on PubMed
Carney RM, Wolpert CM, Ravan SA, Shahbazian M, Ashley-Koch A, Cuccaro ML, Vance JM, Pericak-Vance MA. Identification of MeCP2 mutations in a series of females with autistic disorder. Pediatr Neurol. 2003 Mar;28(3):205-11. doi: 10.1016/s0887-8994(02)00624-0. Citation on PubMed
Chahrour M, Zoghbi HY. The story of Rett syndrome: from clinic to neurobiology. Neuron. 2007 Nov 8;56(3):422-37. doi: 10.1016/j.neuron.2007.10.001. Citation on PubMed
Gonzales ML, LaSalle JM. The role of MeCP2 in brain development and neurodevelopmental disorders. Curr Psychiatry Rep. 2010 Apr;12(2):127-34. doi: 10.1007/s11920-010-0097-7. Citation on PubMed or Free article on PubMed Central
Lombardi LM, Baker SA, Zoghbi HY. MECP2 disorders: from the clinic to mice and back. J Clin Invest. 2015 Aug 3;125(8):2914-23. doi: 10.1172/JCI78167. Epub 2015 Aug 3. Citation on PubMed or Free article on PubMed Central
Lugtenberg D, Kleefstra T, Oudakker AR, Nillesen WM, Yntema HG, Tzschach A, Raynaud M, Rating D, Journel H, Chelly J, Goizet C, Lacombe D, Pedespan JM, Echenne B, Tariverdian G, O'Rourke D, King MD, Green A, van Kogelenberg M, Van Esch H, Gecz J, Hamel BC, van Bokhoven H, de Brouwer AP. Structural variation in Xq28: MECP2 duplications in 1% of patients with unexplained XLMR and in 2% of male patients with severe encephalopathy. Eur J Hum Genet. 2009 Apr;17(4):444-53. doi: 10.1038/ejhg.2008.208. Epub 2008 Nov 5. Erratum In: Eur J Hum Genet. 2009 May;17(5):697. Citation on PubMed or Free article on PubMed Central
Lyst MJ, Bird A. Rett syndrome: a complex disorder with simple roots. Nat Rev Genet. 2015 May;16(5):261-75. doi: 10.1038/nrg3897. Epub 2015 Mar 3. Citation on PubMed
McGraw CM, Samaco RC, Zoghbi HY. Adult neural function requires MeCP2. Science. 2011 Jul 8;333(6039):186. doi: 10.1126/science.1206593. Epub 2011 Jun 2. Citation on PubMed or Free article on PubMed Central
Neul JL, Zoghbi HY. Rett syndrome: a prototypical neurodevelopmental disorder. Neuroscientist. 2004 Apr;10(2):118-28. doi: 10.1177/1073858403260995. Citation on PubMed
Samaco RC, Neul JL. Complexities of Rett syndrome and MeCP2. J Neurosci. 2011 Jun 1;31(22):7951-9. doi: 10.1523/JNEUROSCI.0169-11.2011. No abstract available. Citation on PubMed or Free article on PubMed Central
Signorini C, De Felice C, Leoncini S, Moller RS, Zollo G, Buoni S, Cortelazzo A, Guerranti R, Durand T, Ciccoli L, D'Esposito M, Ravn K, Hayek J. MECP2 Duplication Syndrome: Evidence of Enhanced Oxidative Stress. A Comparison with Rett Syndrome. PLoS One. 2016 Mar 1;11(3):e0150101. doi: 10.1371/journal.pone.0150101. eCollection 2016. Citation on PubMed or Free article on PubMed Central
Skene PJ, Illingworth RS, Webb S, Kerr AR, James KD, Turner DJ, Andrews R, Bird AP. Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state. Mol Cell. 2010 Feb 26;37(4):457-68. doi: 10.1016/j.molcel.2010.01.030. Citation on PubMed or Free article on PubMed Central
Van Esch H, Bauters M, Ignatius J, Jansen M, Raynaud M, Hollanders K, Lugtenberg D, Bienvenu T, Jensen LR, Gecz J, Moraine C, Marynen P, Fryns JP, Froyen G. Duplication of the MECP2 region is a frequent cause of severe mental retardation and progressive neurological symptoms in males. Am J Hum Genet. 2005 Sep;77(3):442-53. doi: 10.1086/444549. Epub 2005 Jul 29. Citation on PubMed or Free article on PubMed Central
Viana MC, Menezes AN, Moreira MA, Pissinatti A, Seuanez HN. MECP2, a gene associated with Rett syndrome in humans, shows conserved coding regions, independent Alu insertions, and a novel transcript across primate evolution. BMC Genet. 2015 Jul 7;16:77. doi: 10.1186/s12863-015-0240-x. Citation on PubMed or Free article on PubMed Central
Young JI, Hong EP, Castle JC, Crespo-Barreto J, Bowman AB, Rose MF, Kang D, Richman R, Johnson JM, Berget S, Zoghbi HY. Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2. Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17551-8. doi: 10.1073/pnas.0507856102. Epub 2005 Oct 26. Erratum In: Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1656. Citation on PubMed or Free article on PubMed Central
Genomic Location
The MECP2 gene is found on the X chromosome.
Related Health Topics
Genes and Gene Therapy
What is a gene variant and how do variants occur?
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Last updated March 1, 2017


American transgender boxer Patricio Manuel created history after winning his bout against Mexican Hugo Aguilar in super-featherweight. The 33-year-old former female contender won his debut pro match on Saturday night at the Fantasy Springs Resort Casino in California.
For the record, Manuel is the first transgender male to fight professionally in the United States. He won the bout with unanimous 39-37 decision victory.
Manuel fought in 2012 London Olympic trials as a female contingent, but bowed out with a shoulder injury. Months later, he had a series of surgery and hormone treatments to transform into a male physique in five years.
The trouble did not end there as a new license issue was delayed by the bureaucracy. At the same time, coaches were unwilling to work with a trans boxer.
When the International Olympic Committee, prior to the 2016 Rio Games, ruled that female to male transgender athletes could compete, Manuel was cleared for the male competition.
Aguilar, who was fighting in the US for the first time didn't know his opponent was a woman. He learned about Manuel's transition just a couple of days before the fight.
However, he said it wasn't a problem and it doesn't change anything for him since both fighters wanted to win the bout.


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Wanted: Judiciary That Aids Economic Growth
By ADEBISI ONANUGA
Despite efforts, delay in administration of justice just won't go away. According to the Chief Justice of Nigeria (CJN), Justice Ibrahim Muhammad, the slow pace of justice dispensation is preventing the sector from playing its required role in economic development. ADEBISI ONANUGA examines the problem and the way out.
Last Thursday, the Chief Justice of Nigeria (CJN) Justice Ibrahim Muhammad bemoaned the delay in justice delivery, noting that it accounts for the Judiciary's inability to effectively contribute to economic development.
Justice Muhammad spoke at a national workshop for judges on recent reforms of the Banking and Financial Services Sector in Nigeria: Bank and Other Financial Institutions Act (BOFIA) 2020 in focus, organised by the National Judicial Institute (NJI), in collaboration with Juris Law and the Central Bank of Nigeria (CBN).
He noted that disputes were unavoidable in business transactions and other related economic activities, but lamented that it would be scandalous if cases arising from failed business transactions lingered for years in court without resolution.
The CJN urged judges and judicial stakeholders to devise prompt dispute resolution mechanisms, saying an effective judicial system was a catalyst for financial system stability, which often translated to economic growth.
"The Judiciary is a critical stakeholder and a necessary partner in the enhancement of financial stability of any country," he said.
He added: "If the Judiciary must play its role in financial stability in Nigeria, cases of delay must be aggressively and frontally addressed so that parties would get justice at the end, and the resultant effect of this would raise public confidence in the Judiciary.
"One of the key factors that will aid the Judiciary in carrying out its assigned responsibilities and essentially ensuring financial system stability is for judicial officers to embrace case management in their courts and thereby aid speedy dispensation of cases in their dockets."
The CJN has a point. But observers have pointed out other factors also responsible for the Judiciary's seemingly inability to contribute to economic development, such as poor enforcement of the rule of law in commercial activities.
'Independent Judiciary leads to rapid growth of small and larger businesses'
Professor Emeritus of American and Foreign Law, Senior Lecturer, The University of Chicago Law School and Senior Fellow at The Brookings Institution, Kenneth W. Dam, observed that a sound judiciary backed by proper enforcement of the rule of law was critical for businesses to thrive.
Dam, in a Chicago Law and Economics Working Paper No. 287, published in 2006, noted that while some technical laws can be enforced by administrative means, the rule of law – in the primary economic sense of protecting property and enforcing contracts – requires a judiciary to resolve disputes between private parties.
He said no degree of substantive law improvement, even world "best practice" substantive law, would bring the rule of law to a country without effective enforcement.
Dam noted that one conclusion widely agreed on, not just in economic circles but also among lawyers and legal scholars, was that the judiciary is a vital factor in the rule of law and more broadly in economic development. He said several studies showed some of the positive benefits of strong and effective judiciaries. According to him, the degree of judicial independence is correlated with economic growth. He said a stronger judiciary was usually associated with the more rapid growth of small firms as well as with larger firms in the economy.
'Better courts reduce firms' risks, increase willingness to invest'
Dam also stated that economic studies showed that within individual countries, the relative competence of provincial and state courts affected comparative economic competitiveness, adding that better courts reduced the risks firms face, and so increase the firms' willingness to invest more in the economy of the country they operate.
Why govt seems to be ignoring commercial disputes
Kemi Pinheiro (SAN), Ogbonna Chukwumerije and Sodiq Lawal argued in an article published in The Nation last month and entitled "Effective judicial system: A catalyst for economic growth" that successive governments in Nigeria do not place much importance on commercial disputes, which have continued to linger in various courts across the country despite the undeniable role an effective judiciary plays in ensuring economic growth.
According to them, it appears that the different arms of the Nigerian Government do not appreciate the role a quick, effective and efficient dispute resolution mechanism plays in the economic development of a country.
Judicial efficiency measured by trial length
The trio emphasised that a well-functioning judicial system was indispensable to business activities and to society as a whole. Judicial efficiency measured by trial length, one of the essential factors in the effectiveness of the justice system, ensures contract enforcement, which is the basis of market transactions, they said.
"Judicial efficiency is closely associated with accessibility to judicial services and the certainty of an efficient judicial system raises people's confidence."
They noted that one of the factors that discouraged investment, particularly foreign investment, in developing countries, was the absence of an effective and reliable dispute resolution mechanism. Judicial efficiency, they added, is closely associated with accessibility to judicial services and the certainty of an efficient judicial system raises people's confidence.
'Time is money'
They noted that while it was almost impossible to avoid disputes in commercial ventures, an investor was concerned about the mechanism in place for resolving any disputes that may arise in the course of his business.
The popular phrase 'time is money', they said, cannot be over-emphasised. No investor is willing to tie down money, capital or investment for an unascertainable period due to commercial disputes. The fear is usually that the investment and/or capital would have lost its value at the time the dispute is eventually resolved.
"Thus, investors would be averse to investing funds in any country where dispute resolution is not reliable, effective and/or efficient. This is the case of the Nigerian judicial system. Many investors and investment have been lost over the years as a result of the failure of successive governments to pursue efficient and/or effective judicial reforms."
They also observed that court-related litigation in Nigeria was majorly characterised by three (sometimes four) stages, commencing from the trial courts, then the appellate court and then the Supreme Court.
They noted that the journey to the Supreme Court in a commercial dispute "could last for as long as eight to 20 years."
In Bilante Intl Ltd v. N.D.I.C (2011) LPELR-781 (SC), for instance, the suit was commenced in 1992 and it continued till June 2011, when the Supreme Court delivered its judgment. Also in Edilcon (Nig) Ltd v. UBA PLC (2017) LPELR-42342 (SC), the decision of the trial court was delivered in December 1997, whilst the decision of the Supreme Court was delivered in May 2017 – about 20 years after.
"It is quite disheartening that, over the years, the heads of the various courts have failed to enact measures geared towards decongesting the dockets of the courts, or even where enacted the measures have proved ineffective, thereby increasing the time span of cases and reducing the confidence potential investors will have in the judicial system," they said.
Delay in justice dispensation must be addressed
Many stakeholders and commentators at different fora decried the menace of delay in dispensation of justice in Nigeria. Justice Niki Tobi of blessed memory once observed that one perennial problem in the administration of justice in any legal system was the question of delay.
"There is so much delay in the administration of justice in Nigeria that one wonders whether the parties get value justice at the end," Justice Tobi said.
Pinheiro and others stated that where litigation takes six years or more to be completed in the High Court is not good enough. They argued that cases of delay must be addressed if the rule of law was to have any meaning, and that more often than not, the investment at stake or money in dispute would have depreciated such that the successful party would gain no benefit from the judgment.
Why arbitration hasn't solved the problem
They lamented that alternative dispute resolution had not solved problems of an inefficient and ineffective judiciary.
They noted further that most arbitrated matters ended in courts either for enforcement of awards or to challenge the arbitrators or their jurisdiction among other things. To buttress their views, they cited the cases of Sundersons Ltd & Anor v. Cruiser Shipping Pte Ltd & Anor (2014) LPELR-22561 (CA); North Pole Navigation Co. Ltd v. Milan (Nig) Ltd (2015) LPELR-25865 (CA).
In these situations, the arbitration or other alternative dispute resolution mechanism is also hampered by delay and inefficient judicial system.
"It is quite incredulous that successive governments in Nigeria have failed to make concerted efforts to reform the Judiciary. It will be recalled that when the politicians were faced with the possibility that the period for the determination of pre-election and election matters would linger at the tribunal for a long time because of the rot in the judicial system as in the case of Ngige v Peter Obi (2006) LPELR-12920, immediate and urgent steps were taken to amend the Constitution to ensure that election matters are determined expeditiously and within a Constitutionally guaranteed time frame (See Section 285 of the Constitution).
"In fact, sanctions are meted out by the National Judicial Commission to judges who fail to determine election matters within the time prescribed by the Constitution.
"The lethargic attitude of the government in ensuring the speedy determination of civil (commercial) cases can be seen from the failure of the Courts to enforce the provisions of Section 53 of the Asset Management Corporation Act of Nigeria (Amendment No. 2), 2019 which seeks to ensure that all AMCON related matters are determined within the time explicitly stipulated in the relevant provision of the Act. Unsurprisingly, unlike matters bordering on election matters, there has been no enthusiasm or zeal to ensure the speedy determination of AMCON matters."
What must be done
The problems are obvious, as are some solutions. Are there others? A former Nigerian Bar Association (NBA) President, Dr Olisa Agbakoba (SAN); Pinheiro, a former General Secretary of NBA, Dele Adesina (SAN) and Dr Fassy Yusuf shared more insight.
Govt must ensure expeditious, fair administration of justice
Agbakoba argued that the judicial system "to everyone's knowledge has completely and utterly failed."
He blamed this on the Judicial authorities' failure to "do anything about it."
Agbakoba said: "I have spoken about this for 30 years. The only exceptions that worked on judicial reforms in relation to the speed of justice were the late Chief Judge of Lagos State, Justice Samuel Ilori, who, under my consultation with the British Council, introduced the front loading procedure. The other judicial officer was the late Chief Justice Dahiru Musdapher, CJN, as he then was. He appointed me to produce a radically new set of civil procedure rules, but this was not implemented as he served for only six months. There were of course some other judicial officers who introduced reforms, such as Chief Judge Roseline Ukeje of the Federal High Court and Chief Judge Ibrahim Auta, also a former Chief Judge of Federal High Court.. But that is it really. "
NJC's 'failure
Agbakoba lamented that the NJC, constitutionally charged with judicial reform, "has done nothing."
He added: "The result is a sad decline in the Judiciary's ability to discharge its function to effectively and efficiently resolve disputes. This is a failure that requires urgent attention otherwise the relevance of the judiciary in the eyes of the public will continue to be questioned. It is not rocket science to modernise the Judiciary and this is a reasonable expectation. The NBA needs to push this process vigorously".
Reform the Judiciary
Pinheiro noted that a functional judicial system played a major role in society in maintaining not just law and order but boosting the economy. He advised that government must "as a matter of great importance" take active steps towards reforming the judiciary to ensure the expeditious and fair administration of justice.
He said: "No serious nation prioritises matters relating to the elections over the economy. An efficient judicial system provides the framework for stability and economic development."
Amend court rules
Pinheiro advocated for robust and holistic amendments to be carried out on the rules of procedure for various courts to extricate provisions that facilitate the delay of court proceedings and include provisions that encourage virtual and information technology mechanisms.
Appoint senior lawyers as judicial commissioners
He suggested that government should encourage and implement the appointment of senior lawyers as judicial commissioners or on an ad-hoc basis at the different levels to immediately dispose of procedural and non-contentious interlocutory applications.
Prompt dispute resolution: catalyst for economic development.
Adesina argued that the type of dispute resolution mechanism that could hasten the resolution of failed financial transactions and business disputes was arbitration and conciliation.
"Our law has made adequate provision for this as a means of alternative dispute resolution mechanism under the Arbitration and Conciliation Act Cap A18 Laws of the Federation 2004," he said.
The Silk regretted that the conduct and attitude of concerned stakeholders had "jeopardised the law from achieving its set goal and objective."
Like Pinheiro, Adesina noted that a good number of cases before the courts from the High Ccourt to the Supreme Court were challenging the enforcement of one arbitral award or the other, some of them on very flimsy and frivolous grounds, even when the provisions of the Arbitration and Conciliation Act are clear on the finality and binding force of the awards of Arbitral Tribunal and the very restrictive and limited grounds under which one could apply to set aside those awards.
"We know for a fact that it is faster and it meets the exigencies of speedy resolution of commercial disputes and other financial transaction disagreements.
"Regrettably, this objective has been largely defeated in Nigeria despite the sustained efforts of our courts to recognise and enforce those awards while rejecting in most of the cases the various attempts of contractual parties to resort to litigation which they had earlier rejected as a means of resolving their disputes under their contractual agreements," Adesina said.
He noted that there were cases where parties voluntarily and expressly agreed to refer their disputes to Arbitral Tribunal to be constituted under the Act. "A dispute will arise, both parties will appoint arbitrators, both parties would participate at the arbitral proceedings and awards would be rendered. What happens thereafter is that the dissatisfied party will turn the arbitration as a starting point for his litigation which may last between 10 and 20 years.
"Of course, this prolongation and endless litigation does not advance the business interest of the parties in any way or the economic interest of the nation as a whole."
'Party challenging arbitral award should deposit award in interest-yielding account'
"It is on this note that I propose an amendment to the Arbitration and Conciliation Act that will make it obligatory that any party who is challenging an arbitral award must first and foremost deposit the award into an interest yielding account in the bank while pursuing the application and appeal to set aside the award. The winning party at the end of the day will go with the money. By so doing, many cases arising from arbitral awards will go.
"Of course, the purpose of arbitration will also be achieved very substantially. After all, it is a fundamental principle of our law that not only is a judgment creditor entitled to the fruit of his judgment, but also, appeal as a matter of general principle does not operate as a stay of execution. Some disputes may still have to be litigated in which case speed in the determination of such dispute will still be necessary.
Factors responsible for slow administration of justice
Adesina also noted that the attitude of many practitioners contributed to slow administration of justice and that this manifested in many areas. He listed them to include: "endless preliminary objections warranting endless rulings or in some cases adjournments; frivolous interlocutory appeals; application for stay of proceedings; frivolous adjournments; petition against Judges and opposing counsel; lack of technology to proceedings; lack of proper apprehension and/or political will to enforce the Rules of Procedure such as personal liability of counsel for cost for any infraction of rules of practise that jeopardises speedy trial and inadequate funding."
Inadequate funding
According to him, inadequate funding is a cankerworm that has eaten deep into the administration of justice in Nigeria.
"A judge once told me that the salary of judges is an incitement to corruption. He wondered why the country failed, refused or neglected to adequately fund justice administration, particularly now that we are operating a constitutional democracy.
"A critical appraisal of budgetary allocation to the judiciary and administration of justice in Nigeria in comparative terms with other sectors of the economy will demonstrate absolute lack of priority attention to the justice sector.
"A speedy, efficient and effective administration of justice that everybody can be proud of, that the investors both local and foreign can rely on and trust can only be achieved if we practically, functionally and realistically address the above challenges with relevant determination to make a change", he said, adding "nothing works by itself, things are made to work."
Why judiciary cannot contribute to economy
According to Yusuf, the Nigerian environment is one of the worst in resolving disputes arising from business transactions "and this should not be because our jurisprudence was taken from Britain and it has exposure to American jurisprudence, to Canadian jurisprudence, to French jurisprudence, German jurisprudence, Asian jurisprudence."
He said these are countries people want to do business with because they believe in justice without delay "and as you know too well, Justice delayed is justice denied and that is why no matter what the federal government is doing about the ease of doing business, if the issue of dispute resolution is not addressed, we would continue to find it difficult to have an inflow of foreign direct investments. Even those already in the country are taking flight and that is why you see many countries moving to Ghana and elsewhere where disputes can be quickly resolved.
"You can imagine a business dispute, a shipping dispute, a dispute arising from airline business dragging for 10 years. Most people would lose fate in the judiciary. To my mind, all these should be eradicated and if they cannot be fully eradicated, they should be curtailed to the barest minimum.
He advised that the NJC and indeed, the National Assembly should devise strategies and mechanisms to promote these resolutions. "It is not only the judge that would have to do this, it is going to be a collectivity, it is going to be the body saddled with the responsibility, that is the top echelon of the realm, the judiciary. And to do this, the National Assembly, the law-making body of the government, the state assembly should come to the aid of the judiciary", Yusuf argued.
Review laws on arbitration
He also advised that the provision for arbitration in statute books, the laws of the federation, the laws of the states, should be re-jigged and should ensure the incorporation of Alternate Dispute Resolution (ADR) in all agreements.
"All agreements must have a clause for ADR. ADR mechanism must be injected into all agreements, including arbitration, mediation and reconciliation. Under ADR, a dispute mustn't last more than two or three weeks and it must be made mandatory that before any matter goes to court, it must first go to ADR. Once ADR clauses are embedded in agreements, then it will be faster to deal with. It is only when ADR processes have been explored that disputes can be brought to court. So, it would just be a formality for the court to adopt or reject. If anybody is not in agreement with decisions at ADR, then that person or body can appeal.
The other way, according to Yusuf, is to ensure that matters are not adjourned indiscriminately. As it is, most courts are overloaded with cases, but then, how much can the government afford for the judiciary? It is limited because you have to juxtapose what the judiciary wants or needs with that of the rest of the country.
Caution on methods of appointment of judicial officers
Yusuf suggested that in the process of appointing judicial officers, there was the need to ensure that there were adequate facilities for them to work with. He described the current system as "anachronistic, laborious, debilitating and too tasking.
"The environment is inclement, not only for the judges, the court officials, the litigants, the lawyers and others. They operate under a harsh environment. They must all be addressed, a situation where the courts are overcrowded, where court lists have about 20, 30 or 40 cases in a day is killing, excruciating and we must deal with these, whether we are going to have the courts expanded or appoint more judges; and they must be given working equipment," he said.
Written By Obioma Ezenwobodo Esq
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ProFootball Talk on NBC Sports
Quarterback of 0-10 team: "I've got to be better"
Darin Gantt
Ryan Finley may not have been given the best chance for success. The Bengals were winless and without their best offensive player but with a messed-up offensive line when the rookie was given the starting job.
That he hasn't turned things around isn't his fault, to say the least. But he's a good sport, so he owned his part of it anyway.
"I've got to be better. I don't think I played well enough for us to win this game," Finley said, via Tyler Dragon of the Cincinnati Enquirer. "A lot of these NFL games come down to one score, and you need to score in the two-minute situations. Just got to be better, all around."
Well, perhaps.
Finley is 29-for-61 passing for 282 yards, with a touchdown and two interceptions in two starts. The 47.5 completion percentage is bad, the 4.6 yards per pass attempt is worse, as he's 1-of-6 on passes beyond 20 yards.
"We are just not getting enough explosive passes, it's got to be so methodical coming down the field, to get the points, and that has really been the story of our year to an extent. Being explosive down the field and getting those long touchdowns," rookie coach Zac Taylor said. "It's not easy, it's not easy. We are just trying to find ways to give our guys a chance to be explosive and we are going to keep searching."
But hey, they're 0-10, so there's room to develop for the future, so there's no real reason to not see what they have in the fourth-round pick.
And if it doesn't work, they'll have a better chance to draft the next one.


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About NCGE
Who manages NCGE
The NCGE Team
NCGE Customer Charter
National Forum on Guidance
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FOI, AIE and Protected Disclosures
Regulation of Lobbying
Further Education & Training
If you do not see the answer to your question below, feel free to contact us at ncgeinfo@ncge.ie or call 01 8690715
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Guidance facilitates people throughout their lives to manage their own educational, training, occupational, personal, social, and life choices so that they reach their full potential and contribute to the development of a better society. This is the agreed definition of guidance of the National Forum on Guidance (2004)
In the context of lifelong learning, guidance refers to a range of activities that enables citizens of any age and at any point in their lives to identify their capacities, competences and interests, to make educational, training and occupational decisions and to manage their individual life paths in learning, work and other settings in which these capacities and competences are leaned and/or used. ... Examples of such activities include information and advice giving, counselling, competence assessment, mentoring, advocacy, teaching decision-making and career management skills. Taken from EU Resolution on Guidance (2008)
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NCGE does not provide a one-to-one guidance service to the public. It does provide information and advice to persons wishing to study or train in another Member State. This service is provided as part of NCGE's participation in the European network of Euroguidance centres, funded by Lifelong Learning Programme.
See the Euroguidance Centre Ireland website
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NCGE does not have a code of ethics though each staff member of NCGE who is engaged in the delivery of guidance is encouraged to become a member of a professional organisation. The Institute of Guidance Counsellors (IGC) is one such professional body which currently represents over 1200 practitioners. The IGC Code of Ethics covers principles concerning competence, conduct, confidentiality, consent and research.
Also of interest to guidance counsellors is the Code of the Psychological Society of Ireland which is based on four principles (respect for the rights and dignity of the person, competence, responsibility, and integrity). The City of Dublin Vocational Education Committee (CDVEC, 1999) has published useful ethical guidelines for guidance counsellors and psychologists working under its remit.
In 2008, NCGE published a code of ethics for individuals carrying out research on behalf of NCGE. Read full report
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Lárionad Náisiúnta um Threoir san Oideachas
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Ireland is the first European country to publicly indicate how its National Framework of Qualification (NFQ) relates to the European Qualifications Framework for Lifelong Learning (EQF). The EQF is a new European tool that aims to increase the transparency of qualifications across Europe.
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Guidance services in the educational sector are based in post-primary schools, higher and further education colleges and through adult and second chance education programmes.
To work in guidance in different educational settings, qualifications vary according to the requirements of the role and the employee.
For more information on the activities of guidance, administrative control, and training and qualifications of practitioners necessary to each setting see Guidance in Ireland (PDF 179 kb)
There are many opportunities to work as a Guidance Counsellor in Ireland, and there are some general 'principles' regarding the training and requirements needed.
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The National Centre for Guidance in Education is an agency of the Irish Department of Education and Skills and was set up in 1995. Its mission is to develop and support quality guidance provision in the education sector as part of lifelong learning in accordance with national and international best practice. NCGE also host the Euroguidance Centre Ireland.
FOI, AIE & Protected Disclosures