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Recommended Study Aids
The following recommendations are provided as a supplement to the many resources provided by the Church in support of the Come, Follow Me curriculum for 2020 on the Book of Mormon. The Come, Follow Me Additional Resources page summarizes all of the Church resources that can be found on ChurchofJesusChrist.org and in the Gospel Library app.
Our Expert's Recommendations
See below for full information on each volume mentioned.
Jeffrey M. Bradshaw
The more than 500 KnoWhy articles at Book of Mormon Central
Knowing Why, Book of Mormon Central (2017)
Knowing Why: 127 MORE Evidences That the Book of Mormon Is True, Book of Mormon Central (2019)
Royal Skousen
The Collected Works of Hugh Nibley, Vol. 6: An Approach to the Book of Mormon, Hugh Nibley (1957)
Comment: Shows the Middle East (Semitic and Egyptian) background to the Book of Mormon
Originally used as the priesthood manual for the LDS Church, 1957
Re-issued in 1964 (and reprinted in 1976) with an additional chapter added
Final, 3rd edition published in 1988, a light revision of the second edition, edited by John W. Welch
"Chiasmus in the Book of Mormon", John W. Welch, BYU Studies 10/1 (1969): 69–84
Comment: Shows the existence of complex chiastic usage in the text of the Book of MormonThis seminal work has been reprinted numerous times, with revisions and additions, as in Noel B. Reynolds (editor), Book of Mormon Authorship (1982), 33–52
Also see Welch's article "What Does Chiasmus in the Book of Mormon Prove?", in Noel B. Reynolds (editor), Book of Mormon Authorship Revisited (1997), 199–224
The Book of Mormon: The Earliest Text, Royal Skousen, Yale University Press, 2009
Comment: Now in its 4th printing. Using the principles of textual criticism, restores the original text of the Book of Mormon, to the extent it can be determined (only 28 percent of the original manuscript is extant) the text is set in sense-lines (that is, with line breaks occurring at the end of clauses and phrases), not only to facilitate the reading of the text, but also in an attempt to replicate how Joseph Smith would have dictated the text to his scribes. There is an appendix listing 719 significant textual variants in the history of the Book of Mormon text (3N) in support of the Yale text.
The Book of Mormon Critical Text Project, Royal Skousen
Volume 1: The Original Manuscript of the Book of Mormon (2001)
Volume 2: The Printer's Manuscript of the Book of Mormon (2001), in two parts
Volume 3: The History of the Text of the Book of Mormon (6 out of 8 parts are now complete)
Volume 4: Analysis of Textual Variants, in 6 parts (first edition, 2004-2009; second edition, 2017)
Volume 5: A Complete Electronic Collation of the Book of Mormon (to appear in 2022)
Two additional parts to volume 3 will appear in 2020-21:
Transmission of the Text: From the Manuscript through the Editions, part 7
Book of Mormon Textual Criticism, part 8
Martin Tanner
The Book of Mormon: Another Testament of Jesus Christ, Grant Hardy, Editor
Comment: Textual notes from Royal Skousen's Critical Text project. It has excellent footnotes and formats poetic passages into appropriate poetic format.
The Sermon at the Temple and the Sermon on the Mount: A Latter-Day Saint Approach, John W. Welch
Comment: Excellent discussion of the similarities and differences between the two sermons.
An Ancient American Setting for the Book of Mormon, John L. Sorensen
Comment: The first and still one of the very best sources which analyses information on where events in the Book of Mormon likely took place.
Mormon's Codex, John L Sorensen
Comment: More information on why the Book of Mormon is an ancient Mesoamerican book.
Second Witness: Analytical and Contextual Commentary on the Book of Mormon, Brandt Gardner
Comment: 6-volume set, available together or individually.
Joseph Smith's means and methods of translating the Book of Mormon: Basic historical information, John W. Welch and Tim Rathbone
Comment: This short paper is an excellent place to start for anyone looking into how the Book of Mormon was translated.
Opening the Heavens: Accounts of Divine Manifestations, 1820-1844, Jack Welch
Warfare in the Book of Mormon, Stephen Ricks and William Hamblin
Isaiah in the Book of Mormon, edited by Don Parry and Jack Welch
Echos and Evidences of the Book of Mormon, Don Parry, Dan Peterson and Jack Welch
Chiasmus in Antiquity, Jack Welch
Legal Cases in the Book of Mormon, Jack Welch
Allen Wyatt
Second Witness: Analytical and Contextual Commentary on the Book of Mormon, Brant A. Gardner
The Gift and Power: Translating the Book of Mormon, Brant A. Gardner
Where to Get Them
415 pages, Deseret Book Co (June 1, 1985)
Hardcover — Amazon
Paperback — Deseret Books, Barnes and Noble
eBook — Deseret Books
Kindle — Amazon
ePub (NOOK Book) — Barnes and Noble
The Collected Works of Hugh Nibley, Vol. 6: An Approach to the Book of Mormon, Hugh Nibley
541 pages, Deseret Book Co: Subsequent edition (March 1, 1988)
Hardcover — Amazon, Deseret Books, Barnes and Noble
The Book of Mormon: The Earliest Text, Royal Skousen
848 pages, Yale University Press, First Edition (September 22, 2009)
Hardcover — Amazon, Barnes and Noble
Volume 1: The Original Manuscript of the Book of Mormon
553 pages, FARMS (2001)
Volume 2: The Printer's Manuscript of the Book of Mormon
Volume 3, Parts 1 and 2: The History of the Text of the Book of Mormon, Grammatical Variation
1304 pages, BYU Studies (April 6, 2016)
Hardcover — BYU Studies, Amazon
Volume 3, Parts 3 and 4: The History of the Text of the Book of Mormon, The Nature of the Original Language of the Book of Mormon
1408 pages, BYU Studies (2018)
Volume 4: Analysis of Textual Variants of the Book of Mormon
6 volume set, FARMS, Brigham Young University (2005-2009)
Hardcover (6 Volume Set) — BYU Studies, Amazon
Hardcover (Individual Parts) — Amazon
Part One: 1 Nephi – 2 Nephi 10
Part Two: 2 Nephi 11 – Mosiah 16
Part Three: Mosiah 17 – Alma 20
Part Four: Alma 21 – 55
Part Five: Alma 56 – 3 Nephi 18
Part Six: 3 Nephi 19 – Moroni 10
Digital (read-only) — Interpreter Foundation
600 pages, Neal A. Maxwell Institute, BYU Religious Studies Center, Deseret Book Company (December 31, 2018)
Paperback — Amazon, Deseret Books
Chiasmus in Antiquity: Structures, Analyses, Exegesis, Jack Welch
353 pages, Neal A. Maxwell Institute for Religious Scholarship (October 1, 1998)
Paperback — Amazon
"Chiasmus in the Book of Mormon", John W. Welch
BYU Studies, Journal 10:1 (1969), pp69–84
PDF — BYU Studies
506 pages, Foundation for Ancient Research & Mormon Studies (November 1, 2002)
379 pages, Greg Kofford Books Inc (August 12, 2011)
Isaiah in the Book of Mormon, Don Parry and Jack Welch, Editors
548 pages, Neal A. Maxwell Institute for Religious Scholarship (November 1, 1997)
Paperback — Amazon, Barnes and Noble
Unknown — Obsolete URL at the Neal A. Maxwell Institute
Knowing Why, Book of Mormon Central
384 pages, Covenant Communications, Inc. (September 1, 2017)
Knowing Why: 127 MORE Evidences That the Book of Mormon Is True, Book of Mormon Central
Audio CD — Amazon, Deseret Books
Audiobook (mp3) — Deseret Books
The Legal Cases in the Book of Mormon, Jack Welch
524 pages, Brigham Young University (May 15, 2008)
826 pages, Deseret Book Company with Neal A. Maxwell Institute (September 3, 2013)
516 pages, BYU Studies, 2nd Edition (January 27, 2017)
Paperback — Amazon, Deseret Books, Barnes and Noble
6 Volume Set
Volume 1: First Nephi
469 pages, Greg Kofford Books Inc (December 18, 2007)
Volume 2: Second Nephi through Jacob
626 pages, Greg Kofford Books Inc (November 28, 2011)
Volume 3: Enos Through Mosiah
Volume 4: Alma
Volume 5: Helaman Through Third Nephi
1459 pages, Greg Kofford Books Inc (November 29, 2011)
Volume 6: Fourth Nephi through Moroni
229 pages, Deseret Book Co; Second Edition (July 1, 1990)
534 pages, Foundation for Ancient Research and Mormon Studies, First Edition (1990)
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The Chain Rivet Setter is a Wenger exclusive. It is added to knives typically made for bicycling.
The tool is a blade mounted type tool.
Created by stressmaster5000. Last Modification: Thursday 09 of August, 2018 12:26:39 CEST by Nick4.


text:
Courant Community Hartford
Cops: Couple Was Growing Marijuana At Farmington Home
HILDA MUÑOZ
Police officers attempting to serve a 48-year-old man with an arrest warrant charging him with traffic violations discovered he and his girlfriend were cultivating marijuana at their Birdseye Road home, police said.
Two handguns, a shotgun, 13 pounds of marijuana, paraphernalia for using and growing marijuana and $900 were found inside the home, police said.
Gary Marchesi and Amelia Morelli were charged with possession of drug paraphernalia, possession of a controlled substance with intent to sell, illegal cultivation of marijuana and possession of more than 4 ounces of marijuana.
Both suspects posted bail.
Marchesi was also served with the warrant charging him in an incident Aug. 4 where he allegedly engaged police in a car chase. He was charged with disobeying signal, failure to keep right on a curve, driving with a suspended license and speeding.
In that incident, police had attempted to pull Marchesi over on Route 6 for allegedly driving erratically. He sped away, police said.
Officers discontinued their attempt to stop him and applied for an arrest warrant. Officers went to Marchesi's home at 116 Birdseye Road on Friday to serve the warrant.
Morelli told police he wasn't home and then attempted to hide marijuana that was in plain view inside the home, police said. Officers secured the home until narcotics officers arrived with a search warrant.
While officers searched the home, Marchesi was seen driving to the end of the street. He turned off his car and attempted to hide in the woods. He was arrested after officers ordered him to get out of the woods, police said.

redpajama_set_name: RedPajamaCommonCrawl


text:
Cape Farewell – Creative Responses to Climate Change
Shift Encounters, a series of talks dealing with climate change and culture at the Southbank Centre in London, came to an end yesterday. Contributor Alan Gillingwater was there and gives his views on a talk on the role of architects in creative responses to climate change.
Written by Alan Gillingwater
Jared Schiller with David Byrne
All photographs and videos courtesy of Tate Shots except where otherwise stated.
Back in 2002 whilst still a skint student, cheapest I started what was then my idea of a dream job: ticket seller at Tate Modern and Tate Britain. I got to see great art and even meet the odd artist or two. I remember Gustav Metzger insisting he paid to see Barnett Newman, and Tony Oursler successfully blagging a freebie to the Turner Prize. Bridget Riley even gave us a personal tour of her exhibition. Fast forward five years and I've landed a job helping Tate Media launch a new video podcast: TateShots. These days I produce and commission the TateShots series, in which we interview artists about the business of making art, and talk to famous gallery-goers about their favourite art shows. The job has given me the opportunity to nervously meet heroes of mine like Jeff Koons, Laurence Weiner and Martin Creed, as well as artists I'm less familiar with but who become firm favourites.
We've made 150 episodes of TateShots so far, and it now comes out weekly. This week we launched a new strand called Sound & Vision. The series took the films' director, Nicola Probert, and I, all over the country to interview musicians who make art. Billy Childish, Lydia Lunch, Mark E Smith, David Byrne, Jeffrey Lewis and Cosey Fanni Tutti all helped us with our enquiries about where art and music collide.
Jared Schiller with Jeff Koons
Billy's interview was probably the most memorable. We filmed him in a cramped bedroom he uses as a studio in his mum's house in Whitstable, surrounded by stacks of paintings. There was hardly enough room for him to paint, let alone for us to film. Billy's musical and artistic reputations arguably couldn't be more different. As a musician he is cited by bands like The White Stripes as an influence – his dedication to lo-fi recording and performance make him the very definition of authentic. On the other hand, as an outspoken critic of conceptual art, his standing in the art world is a little harder to pin down. Because of this big difference, Nicola had the idea to get Billy to interview himself. So Artist Billy asked Musician Billy questions (e.g. "Do I have an influence on you?" Answer: "No."), and explains how he went through a ten year stretch of only painting to the music of John Lee Hooker (almost). The whole experience made me think that it's only a matter of time before Billy Childish is unmasked as the ultimate conceptual artist…
Going forward I would love to make more videos about pop stars with a taste for art. Before we embarked on this series we had already spoken to Alex James from Blur about Ellsworth Kelly, and John Squire from the Stone Roses about Cy Twombly. Apparently Jay-Z is a massive Richard Prince fan, so perhaps he should be next on my list.
Jared Schiller photograph courtesy of Simon Williams/O Production
What Jared likes:
Places: Moel-y-Gest, a hill near Porthmadog in North Wales
Food: Pizza. My dream is to build a pizza oven in my back garden. It will never happen but I keep hold of the dream..
Drink: An Islay Whisky is the perfect late night tipple.
Website: http://www.tate.org.uk (of course)
Music: Currently the new Four Tet album.
Books: Currently reading 'Then We Came to an End' by Joshua Ferris. I mainly have a weakness for any kind of exhibition catalogue or artist's monograph.
Film: I'm looking forward to Chris Morris's 'Four Lions'.
Shop: Alter 109 is a really good men's boutique in Greenpoint, Brooklyn.
Back in 2002 whilst still a skint student, order I started what was then my idea of a dream job: ticket seller at Tate Modern and Tate Britain. I got to see great art and even meet the odd artist or two. I remember Gustav Metzger insisting he paid to see Barnett Newman, ed and Tony Oursler successfully blagging a freebie to the Turner Prize. Bridget Riley even gave us a personal tour of her exhibition. Fast forward five years and I've landed a job helping Tate Media launch a new video podcast: TateShots. These days I produce and commission the TateShots series, viagra sale in which we interview artists about the business of making art, and talk to famous gallery-goers about their favourite art shows. The job has given me the opportunity to nervously meet heroes of mine like Jeff Koons, Laurence Weiner and Martin Creed, as well as artists I'm less familiar with but who become firm favourites.
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SHIFT Encounters was put together by the organisation Cape Farewell. Founded by David Buckland in 2001, medicine Cape Farewell has sought to move beyond the scientific debate of climate change by involving artists in provoking and engaging the public. I like this approach; it seems to be a really important way to start thinking more positively about how we respond to climate change and look to the future. It is often so easy to be mired in the worrying statistics that we forget that the future is not set on a fixed, view predetermined path, buy information pills but is something that, with a little imagination, we can shape and plan. Artists can help us make this leap. Illustrations by Diana Boyle of Rooftop Illustrations
Last week I went to see the talk on architecture, bringing together practicing architects, lecturers and a technical consultant. The panellists were well chosen, each bringing to the table their own perspective and expertise so the discussion was refreshingly lively and the kind of group-think around an issue where everyone is already in agreement and no progress is made was happily avoided.
A wealth of arresting facts was presented. Any initial doubt about the importance of architecture when thinking about climate change was quickly dispelled with the striking estimate that over half of the energy used in the UK is through our buildings. Architects were keen to point to the importance of the users of buildings as well as the designs in achieving energy efficient architecture. Office workers have become accustomed to buildings using energy to maintain a constant temperature throughout the day (through heating and air conditioning) rather than regulating this themselves by putting on, or taking off, a jumper. So part of the change required is in people's minds as well as the brick and mortar.
Perhaps most interesting were the personal stories told. One architect recounted how after an environmental assessment of their offices, he was shocked to discover that 60% of the energy use was outside of working office hours. This was due to the amount of energy required to maintain the servers which were left on constantly. Such surprising results show, I think, the usefulness of such assessments in getting our response to energy use in proportion. For example, we take care in changing light bulbs to energy efficient ones when perhaps we might be better off worrying about the massive amounts of energy needed to heat unused rooms.
The most enjoying part of the talk, however, was the audience's contribution to the discussion. Once the debate was opened up, the focus quickly moved away from a preoccupation with the office environment, towards much broader questions. These were both more difficult and more exciting to attempt to answer. How is it possible to achieve the cultural shift required to reduce energy use in our homes? Should this shift be regulated by the government or is the only way through localised self organisation?
Provocatively, one disarmingly simple question was posed to the architects. Why talk about all these high profile new 'zero-carbon' building developments when what we need to do is not build more, but make the housing stock that we already have more efficient? I think this question cut to the heart of the debate and helped to illuminate some of the forces in play in trying to create more sustainable architecture. Whilst less glamorous than iconic new developments, and certainly a more tricky investment proposition, increasing the efficiency of the buildings we have already would surely be the most effective way of reducing the total energy use of our architecture.
Written by Alan Gillingwater on Monday February 1st, 2010 2:15 pm
Alan Gillingwater, architecture, Cape Farewell, Climate Change, Diana Boyle, Rooftop Illustrations, Shift Encounters, Southbank centre
Climate Forum Weekend: 14th-15th June
Warm-up for Copenhagen!
Earth Listings: 12 – 18 October
Spitalfield's talk by Dan Cruickshank
Britain's Got Refurbishment
One Response to "Cape Farewell – Creative Responses to Climate Change"
Great article and I love the illustrations.
Great ideas for homemade Christmas Decorations for 2013


Home teams get better treatment from umpires and referees, according to this new book.
"Root, root, root for the home team." It's a tuneful ditty to sing during the seventh inning stretch, but it won't help Padres fans. They should really sing, "Pray, pray, pray for the umpires to act as they normally do" — that is, biased toward the host team.
That is one of many conclusions of a delightful new book, Scorecasting, by Tobias Moskowitz, a professor of finance at the University of Chicago, and Jon Wertheim, a writer for Sports Illustrated. They apply exhaustive statistical analysis to sports of all kinds and reach some iconoclastic conclusions that blindly devoted fans may not like but would be well advised to study.
There are lessons for both the Padres and the Chargers. In fact, the book, in describing fatuous decision-making in the pro football draft, cites both very smart and very dumb moves by the Chargers.
First, the home team. Yes, statistics definitively prove that the home team in major sports wins more often than the visiting team. The difference is greatest in soccer. In America's Major League Soccer, the home team triumphs 69.1 percent of the time. The home team wins more than 60 percent of the time in Europe and South America, where soccer is more a religion than a sport.
Home teams are more likely to be successful when stealing a base or turning a double play (Padres vs. Brewers, May 2, 2010).
Home teams have the least significant advantage in Major League Baseball. Between 1903 and 2009, home teams have won 54.1 percent of the games. The authors refute the reasons most often given: (1) Crowd support. Nope. "Fans' influence on the players is pretty small," say the writers. (2) Travel rigors doom visitors. Not statistically valid. (3) Home teams benefit from easier schedules. It's true that big college football teams jack up their won-loss records by scheduling sissy schools at home, but that's not a big enough factor to explain the overall phenomenon. (4) Baseball teams tailor their rosters to fit the idiosyncrasies of their ballparks. Listen up, Padres: that's no ticket to inordinate home success. I'll consider that below.
" 'Officials' bias' is the most significant contributor to home field advantage," say the authors, and they make a superb statistical case for it — pointing out, for example, that soccer outcomes are the most dependent on referees' calls. Looking at reams of game data, Moskowitz and Wertheim show that in baseball, home teams strike out less and walk a lot more per plate appearance than do the visitors. Further, when the game is close, home teams have an even larger advantage in umpires' ball and strike calls. Similarly, home teams are more likely to be successful when stealing a base or turning a double play.
Then came a point in the book when I slammed it down and screamed "Horse manure!" The authors insist that most if not all officials are "uncorrupted and incorruptible, consciously doing their best to ensure fairness." After I recovered from my outburst, the authors hedged their bets. "In a variety of ways — some subtle, some not — officials must take in cues that the league has an economic incentive for home teams to do well." Right on! Sports are part of the entertainment business. And game-fixing is another variable.
Now let's go back to the Padres. Petco Park is designed to be a pitchers' park. The team hopes to win by stacking up on good pitchers and fleet, sure-handed fielders. In other words, defense wins. The book cites multiple statistics showing that defensive-minded and offensive-minded teams win about equally in all sports. In baseball, the authors show that teams molded to their ballparks' peculiarities don't necessarily have an advantage. Pitchers' parks aren't a panacea, and teams that beef up on sluggers to take advantage of a hitters' park don't clean up, either.
Young figured that from 2004, when Petco opened, through 2010, the Padres won 52.9 percent of their home games, while Major League Baseball home teams were winning 54.6 percent of theirs. "The question of whether the Padres are using Petco Park to their greatest advantage remains open," said Young. This year's experience would hardly seem to make the case — at least thus far in the season. They are now 7 wins, 14 losses at home.
Even though it's not certain that there will be a pro season in 2011–2012, the National Football League went through with its ritual draft of college players last month. As always, controversy raged. Scorecasting points out how team managements, clinging to hoary theories, continue to make big draft blunders. A classic example is the 2004 draft in which the Chargers snookered the New York Giants, who desperately wanted Eli Manning, brother of the league's best quarterback. Other top quarterbacks available were Philip Rivers and Ben Roethlisberger.
The Chargers took Manning first. He didn't want to play in San Diego. The Giants could have traded for a lower pick and taken Roethlisberger, but they were so hot for Manning that they drafted Rivers and then gave him and three draft picks to the Chargers for that first pick. The Chargers got Rivers; Pittsburgh got Roethlisberger with the 11th pick. The Giants "effectively considered Eli Manning to be worth more than Ben Roethlisberger plus four additional players," write Moskowitz and Wertheim sardonically. And the first pick in the draft typically is paid about 80 percent more than the 11th pick. National Football League general managers grossly overvalue the high draft picks.
But the Chargers can be taken too. Almost all San Diegans are aware of the 1998 draft in which the Chargers traded away three top picks plus active players to move up to second place in the draft and land Ryan Leaf, who has since landed in a heap of trouble and never amounted to anything in the sport. By trading up to get a supposedly top player, then paying him a monstrous salary, a team often pays "the price of a Porsche for a clunker," write the authors. By taking top picks, "you will never get a great player at a cheap price." But just try to tell that to the National Football League.
May 12, 2011 @ 8:09 a.m.
"Home teams get better treatment from umpires and referees, according to this new book."
An interesting premise, I have a couple of thoughts on this story.
So in baseball, with 162 games and balance between home and away games, the bias canceled out???
But in the playoffs, whether is baseball, football or most any sport the team with the higher seed gets the call. So are the authors implying the SuperBowl in the pros, and bowl games at the college level, where teams play at neutral sites, are NOT biased by the officiating?
One man does not a football team make...but with that said, Eli Manning and the Giants have a SuperBowl ring since he's been at the helm quarterbacking the team. Rivers and the Charger can't past the second round of the playoffs with, what most who follow the stats say, they have a much deeper talent pool. So much for stats.
Now who was snookered in the 2004 draft, it wasn't the Giants as you say. It was Charger fans by Spanos. All that 2004 nonsense did was allow Spanos to raise prices over and over for all the overrated talent. Talent that has yet to deliver us to the promise land and never will while a billionaire gets richer.
May 12, 2011 @ 2:23 p.m.
May 12, 2011 @ 9:06 a.m.
These authors have spoken heresy. Why, if the fans thought the refs and umps were showing bias, it would go far to lessen the interest in the sports in question. if you can't believe in the fairness of the officials, what basis is there for really thinking that "your" team can come out on top if only it outplays the other team?
Biased officiating has been a scandal of sorts in college sports over the years, resulting in some teams finding it hard to get other school's teams to play them. (A few years back there was some obviously biased officiating going in favor of Washington State in its home football games. Hmm. Didn't Ryan Leaf come from there?) But supposedly those few cases are dealt with and only rarely recur. Uh, huh.
Any time that a team starts to do better than it whould do, and when there is a reason or need for its success--such as a stadium/ballpark election--the fix is suspected. Now they are saying that officiating could be the cause and means of affecting the outcome. Nothing is sacred, is it?
May 12, 2011 @ 2:27 p.m.
May 12, 2011 @ 2:43 p.m.
Ah yes.... Shoeless Joe Jackson... He is remembered for his performance on the field and for his association with the Black Sox Scandal, in which members of the 1919 Chicago White Sox participated in a conspiracy to fix the World Series.
May 12, 2011 @ 5:18 p.m.
May 14, 2011 @ 7:02 p.m.
Alas, it always has been thus . . .
About the only remaining argument for "professional" sports teams is that it diverts the yahoos from committing worse crimes (except maybe for child neglect and wife-beating.
Congratulations, btw, on the new format; both your blogs and articles on the same page! At least one of my pleas has been answered!
May 14, 2011 @ 9:44 p.m.
May 15, 2011 @ 2:51 p.m.
George used a real purty little perfume bottle, one of those little crystal thangs wit a little (pink sequined?) rubber bulb. I could never figger out whether he was striking a blow for tranvestite rights or makin' fun oughta 'em. Didn't he wear a cape too?
In the wrestling business they would always ask you if you were a "bleeder." If you were, the other guy (or George) would have some tape on his fingers with razor blades sticking out just a little, almost flat against the tape. Your "opponent" would wait until you got up a sweat, then would scrape your forehead by drawing the blade backwards across your forehead following on the heels of some "terrible injury" or another. A little blood mixes with a lot of sweat made quite a prop.
Any-way, the whole gol-durned world is a flim-flam factory now. That's why I ain't got no confidence in "The Economy."
May 15, 2011 @ 6:11 p.m.
May 15, 2011 @ 8:23 p.m.
I ain't sure neither, but I remember it as being George. Maybe there're some old kineoscopes or still photos?
May 16, 2011 @ 6:51 a.m.
May 16, 2011 @ 6:53 a.m.
May 16, 2011 @ 4:55 p.m.
The NL West is their division, not their league. And in terms of on the field, I would argue that the NL central is no better than the NL west, if not worst. The Cubbies, Astros and the Bucs were 3 of the worst NL teams last year and aren't any better this year. And in the Al, the central is not much either. The only suprise is the Indians playing so well and the Twins sucking so bad; at least they can fairly claim injuries as their. Excluding the AL east which is hands down the best division in baseball, last year there was only about a 3-4 difference percentage wise between all of the other divisions. When it all shakes out, I would expect this year to be the same.
May 16, 2011 @ 6:26 p.m.
May 16, 2011 @ 10 a.m.
There's little indication of that this season looking at from their current place in the standings, the cellar.
May 16, 2011 @ 11:37 a.m.
March 15, 2012 @ 10:28 p.m.
I completely agree. It is just a statistical and emotional phenomenon. Teams do better at home. Look at the schedule: www.inthecitysandiego.com/san-diego-padres-game-schedule.html for 2012 looks to be a repeat for sure.


text:
Ghettos 15
Afro-Americans - Social conditions 12
War on Poverty 11
Riots 10
Discrimination in Employment 8
Emancipation Proclamation 8
Agape 7
India trip 7
''The Climax of A Struggle,'' Statement on 5/10/1963
New York Amsterdam News, 25 May 1963.
''Gandhi Memorial Lecture, Howard University, Washington, D. C., November 6, 1963''
Enclosure of 640521-018.
SPAN, Volume V, Number 5 (May 1964): 23-26, 47-48.
Howard Universtiy
Washington, D. C.
''Of Montgomery and a Historic March: Montgomery March No Accident,'' Address on 3/25/65
SCLC Newsletter 2 (April-May 1965): 9-10.
Woodward, C. Vann (Comer Vann)
The Strange Career of Jim Crow
Lift Every Voice and Sing
''The American Dream,'' Address on 7/25/1965 in Winnetka, Illinois
North Shore Summer Project Newsletter, 6 August 1965, pp. 2-3.
Liuzzo, Viola
Herskovits, Melville J. (Melville Jean)
Bickham, Martin H.
Davis, Emory [North Shore Summer Project]
North Shore Summer Project
NSSPC-ICIU
North Shore Summer Project, University of Illinois at Chicago Circle
''The Church Remaining Awake Through a Great Revolution,'' Ware Lecture delivered on 5/18/66 to the General Assembly of the Unitarian Universalist Association
Boston, Mass.: Unitarian Universalist Association, 1966.
Greeley, Dana McLean
Cole, David
Hawkins, Alfred
Jack, Homer Alexander
Hope, Bob
Arlington Street Church (Boston, Mass.)
National Council of the Churches of Christ in the United States of America. Commission on Religion and Race
Calcutta, India
Bombay, India
PSC-P
Swarthmore College Peace Collection, Swarthmore, Pa.
''A New Heaven and a New Earth,'' Address on 10/29/67
Council Journal 6 (January 1968): 2-7.
John, the Apostle, Saint
Remaining Awake Through a Great Revolution
BEMP-DHU-MS
Benjamin E. Mays Papers, Howard University, Washington, D.C.
''The American Dream,'' Address at Lincoln University on 6/6/1961
Negro History Bulletin 31 (May 1968): 10-15.
Weber, Alfred
MacIver, Robert M. (Robert Morrison)
Einstein, Alfred
Carver, George Washington
Hayes, Roland
Toscanini, Arturo
Bethune, Mary McLeod
Owens, Jesse
Martin Luther King, Jr. - Honors
''Yes, We Shall Overcome,'' Address on 11/20/63
Garden City, N.J.
Gayle Addison, ed. Bondage, Freedom, and Beyond, Garden City, N.J.: Doubleday: 1971, pp. 142-147.
King, Yolanda Denise
A.G. Gaston Motel
Bondage, Freedom, and Beyond
The Challenge of the Hour
The Pursuit of Excellence in the Realm of Human Relations
5/10/2012 kpp
''A New Sense of Direction,'' Address on 11/28/67
Worldview 15 (April 1972): 5-12.
Acton, John Emerich Edward Dahlberg Acton, Baron
Guevara, Ernesto
The Wretched of the Earth
State of the Movement


Bringing his bespoke shoemaking experience to his RTW line, Allan Baudoin and his team handmake each slipper in their workshop in London. Specializing in unlined slippers, each shoe has a handcrafted insole with a cushioned inset, making them extremely comfortable while accommodating a wide variety of widths. The Sagan tassel loafer is crafted from supple suede lambskin, tanned locally and exclusively for them.


School Policies, Student Body, What's New?
From May 15 through May 17th, the Newfound music students and Thespian Society will be going on a trip to New York City. For a price of about $450, this three day, two-night trip will take the students to two Broadway shows, "Once on This Island" and "Hello Dolly." The students will also spend time in Times Square shopping and hanging out at the hotel's pool.
Every other year, the music department goes to a competition or to see a musical performance. Since the music department went to a competition last year, this year they went on a performance trip. For this trip, NRHS faculty and administration believed it would also be a good experience for the Thespians in Newfound to see Broadway live, as well.
Since the price of this year's trip was higher than normal, there were students who could not afford to go. However, many students raised funds to cover the cost of the trip. "I waited a little longer until I had all my funds to pay off the whole trip, and used all the fundraisers I could to pay it off myself," stated senior Makayla Pixley. There were also other activities throughout the trip that would have cost extra if they were not part of the original price. "The cost of the trip is absolutely reasonable for what the students will experiencing; we are going to New York and seeing two on-Broadway shows," stated Victoria Roman.
The date for this band trip occurred in the middle of the school week and interfered with school work for these students, but both Victoria and Makayla believe that the smartest way to not fall behind is to be proactive and ask teachers for school work before leaving.
They will be going to a different state and a different environment, seeing two Broadway shows and it will bring students closer to their music side.


Yep, it's that time of the year again, where I'm juggling the Day Job, Christmas present purchasing (and wrapping, and mailing), whatever writing project I happen to be working on, posting my year-end review at the writing blog, creating my Best of Year compilation, and posting my Best of Year lists here.
As usual, I'll hold up until the last week or so of this month before I post those last two, because I like giving December releases a chance at impressing me. (Like the new U2 album, for instance.) I will say 2017 has been quite an interesting year musically; it seemed like Nearly Every Single Band Jonc Loves put out an album this year! And lots of solid career retrospectives. There were also a lot of new finds that blew my mind as well. I'm not sure if I can call it a banner year, but it certainly was quite enjoyable tunage-wise.
If anything, listening to music was definitely a highly-welcomed and much-needed escape from the ups and downs of Real Life. And I'm pretty sure you know what my biggest headache was; the Day Job was the least of my stresses. I won't say I'm a pessimist in general, though I know all too often I let myself fall down that rabbit hole. I kept a distant eye on what was going on, and I had my tunes to keep me sane and slightly distracted so I could stay positive. And for that I'm eternally grateful.


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Mental Health Startup Aims to Help Patients Access Psychedelic Treatment
As the medical and scientific community embrace psychedelic treatment, and as regulators clear these treatments, a need has arisen to take prospective patients through the entire process so that they make informed decisions and know who to turn to for help. Osmind, a mental health startup, has risen to the occasion to provide the needed support.
Osmind aims at creating a community for people seeking psychedelic treatments which have FDA-approval. Currently, only ketamine has this regulatory approval, but industry insiders expect similar approval to be given to psilocybin and MDMA. Osmind is building an app as well as an online platform through which patients can learn about all available psychedelic treatments. The Osmind community is especially geared towards patients who have mental health conditions that are resistant to the existing treatments.
Osmind is the brainchild of Jimmy Qian and Lucia Huang. The two met at Stanford University during a healthcare IT class. Qian was a student at the medical school at Stanford while Huang was at the business school. The shared IT class therefore gave them an opportunity to meet and realize that they both had a passion for mental health.
Jimmy Qian reveals that as a medical student, he had seen the data on what toll mental health conditions are taking on the U.S. population, and what he read about ketamine blow his mind away.
Similarly, Lucia Huang is emotionally invested in their project because she has firsthand experience of what depression and other mental health conditions have done to family members, friends and college students.
Consequently, the pair is excited about what psychedelics can do for millions of people, and they would like to do their part to make safe and responsible access to psychedelic treatments easy for those who need it.
Their online community is already active and it is a place where people can go when they need support, and those who can offer this needed support also get the chance to help others. Already, information verified by medical doctors is available to those who join the online community.
This community is particularly important during this COVID-19 pandemic since human contact is minimal and yet that is what mental health patients need the most. The platform provides information about the different licensed clinics where patients can access psychedelic treatments. The startup also avails information about the ways in which services are provided at those treatment centers.
For example, community members can know whether a given facility provides e-prescriptions or prescriptions are provided only after an in-person visit to the facility. Ultimately, the startup intends to help advance research into different life-changing medicines, especially psychedelics.
The work of Osmind ties in very well with what other entities, such as Compass Pathways and Salvation Botanicals, are doing to advance the field of psychedelics. The future can only get brighter for people suffering from mental health disorders!
About PsychedelicNewsWire
PsychedelicNewsWire (PNW) is a specialized content distribution company that (1) aggregates and distributes news and information on the latest developments in all aspects and advances of psychedelics and their use, (2) creates PsychedelicNewsBreaks designed to quickly update investors on important industry news, (3) leverages a team of expert editors to enhance press releases for maximum impact, (4) assists companies with the management and optimization of social media across a range of platforms, and (5) delivers unparalleled corporate communication solutions. PNW stays abreast of the latest information and has established a reputation as the go to source for coverage of psychedelics, therapeutics and emerging market opportunities. Our team of seasoned journalists has a proven track record of helping both public and private companies gain traction with a wide audience of investors, consumers, media outlets and the general public by leveraging our expansive dissemination network of more than 5,000 key syndication outlets. PNW is committed to delivering improved visibility and brand recognition to companies operating in the emerging markets of psychedelics.
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A Look at the Potential of Psychedelics in Treating Bipolar Disorder
Take Your Pick: Synthetic Psilocybin or Magic Mushroom Pills?


Take your outfit seamlessly from work to drinks with these stylish tapered-leg trousers from the edit by stylist Mark Heyes, featuring a smart front crease and a flattering cut. With their soft fabric and high elasticated waist, they are super comfortable too. The gold-look metal horseshoe detailing at the top loops adds extra personality, making them great for evening wear.


Moss Camp and Cloud Camp Coming to Chicago!
CloudCamp is an unconference where early adapters of Cloud Computing technologies exchange ideas. With the rapid change occurring in the industry, we need a place we can meet to share our experiences, challenges and solutions. At CloudCamp, you are encouraged you to share your thoughts in several open discussions, as we strive for the advancement of Cloud Computing. End users, IT professionals and vendors are all encouraged to participate. Register at this site today!
Join us for the second annual MOSSCamp in Chicago, IL. MOSSCamp is an event focused on building applications on the SharePoint (WSS and MOSS) Platform. This year the event will be focused on building out an application over the course of the day, as a series of speakers will add functionality to a SharePoint site during a series of presentations throughout the day. Register NOW as this event sells out quickly!


A joint R&D team from Continental and EasyMile has started working on solutions for driverless mobility in Continental's Singapore office. EasyMile (Toulouse, France) is considered a pioneer in the development of autonomous vehicle solutions. The joint team will focus on the development of new technology in the field of perception and machine learning.
Continental and EasyMile will jointly prepare an Autonomous Driving (AD) technology for testing with the aim of achieving the safe use of such vehicles on public roads in the Singapore Municipality. During the celebrations to mark the launch of the R&D initiative and the signing of the Memorandum of Understanding (MoU), guests were able to get an impression of driverless mobility by driving the electrically powered development platform CUbE (Continental Urban Mobility Experience) based on the Easy-Mile software.
With its advanced regulatory kit for AD, Singapore has the flexibility to quickly adapt the regulatory framework to support the rapid pace of AD technology development without compromising public safety. Autonomous systems play an important role in their plans to improve Singapore's transportation system. According to Singapore authorities, AD has the potential to serve the "last mile" between private homes and public transportation hubs.
In particular, driverless vehicles are seen as links between home and the nearest public transport access point. A good connection should contribute to the overall efficiency and performance of transport. To make progress here, Singapore has started an intensive dialogue with leading industrial companies. The aim is to develop driverless solutions as quickly as possible to complement efficient urban mobility.
With the signing of the MoU and the deployment of the team, EasyMile and Continental expand an ongoing collaboration that began in 2017 when Continental acquired a minority stake in the French company. "Once our new R&D team is up and running, our long-term goal will be to provide an autonomous vehicle for Singapore's roads based on Continental's and EasyMile's global expertise, creating safe driverless solutions," says Kien Foh Lo, Managing Director of Continental Automotive Singapore.


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au:"Liping WANG" (239)
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Outcome of extracorporeal membrane pulmonary oxygenation after congenital heart diseases in pediatric: experience from single center / 中国小儿急救医学
Xi CHEN; Mingjie ZHANG; Liping WANG; Yachang PANG; Jiaqi LIU; Zhuoming XU.
Chinese Pediatric Emergency Medicine ; (12): 126-130, 2021.
Article in Chinese | WPRIM | ID: wpr-883169
Objective:To review the clinical prognosis and causes of death in children with extracorporeal membrane pulmonary(ECMO) assistance after congenital heart disease(CHD) operation in our center, so as to improve the survival rate of ECMO.Methods:All clinical data of 105 children with VA-ECMO assisted after CHD operation who were admitted to the Department of Cardiothoracic Surgery at Shanghai Children′s Medical Center from January 2017 to December 2019 were collected, and the clinical characteristics and causes of death were retrospectively analyzed.Results:The age of 105 children with ECMO was 110(38, 341)days, the weight was 5.30(3.75, 8.45)kg, and the risk adjustment for congenital heart surgery score was 3(2-3)points.There were no statistically significant differences in gender, age, weight, height, risk adjustment for congenital heart surgery score, the number of ECMO installed in the operating room, the number of ECMO installed after cardiopulmonary resuscitation and ECMO duration between the surviving group ( n=51) and the death group ( n=54)( P>0.05). While there was a significant difference in utilization of continuous renal replacement therapy[7.8% (4/51) vs.38.9% (21/54), P<0.001]. The death mainly occurred within one week after evacuating ECMO(83.3%, 45/54). ECMO installation was most in children aged 1 month to 1 year old(52.4%, 55/105), and the survival rate showed a rise over three years(2017 to 2019), increased from 31.6% (6/19) to 65.0% (13/20). Children with 3 to 5 kg were the most affected (39.0%, 41/105) when ECMO was installed, and the survival rate from 2017 to 2019 increased from 28.6%(4/14) to 75.0%(9/12). The main cause of death was heart failure(48.1%, 26/54), followed by bleeding(18.5%, 10/54)and pulmonary hypertension(13.0%, 7/54). Conclusion:With the progress of surgical technology and cardiopulmonary bypass, and the improvement of postoperative management, the mortality of children with CHD in our hospital after ECMO has decreased year by year during the last three years.However, the mortality of children requiring continuous renal replacement therapy assistance during ECMO is higher.Therefore, it is still necessary to strengthen the maintenance of each organ function during ECMO.
Antiviral effect of entecavir in chronic hepatitis B patients with rtA181V/T mutation / 临床肝胆病杂志
Shuqin LI; Jing ZHOU; Yuan GAO; Xiaoyan MA; Liping WANG.
Journal of Clinical Hepatology ; (12): 1053-1058., 2021.
Article | WPRIM | ID: wpr-876645
ObjectiveTo investigate the clinical effect of entecavir (ETV) rescue treatment in chronic hepatitis B (CHB) patients at the onset of rtA181V/T mutation. MethodsA total of 174 CHB patients who were treated in the outpatient and inpatient departments of The Affiliated Hospital of Xuzhou Medical University from January 2012 to January 2017 and underwent the detection of drug-resistance mutations of the genes in the reverse transcription (RT) polymerase region were enrolled, among whom there were 72 previously untreated patients and 102 treatment-experienced patients with virological breakthrough or poor response. The association between the previous medication history of nucleos(t)ide analogues and the mutation pattern (including rtA181V/T) was evaluated in the treatment-experienced CHB patients. A total of 155 patients were enrolled, among whom 72 patients had no drug-resistance mutations, 45 had rtA181V/T mutation, and 38 had rtA181V/T+rtN236T mutation. The three groups were compared in terms of virologic response and biochemical parameters at baseline and at weeks 24 and 48 of ETV rescue treatment. The t-test was used for comparison of normally distributed continuous data between two groups, and a one-way analysis of variance was used for comparison between multiple groups; the Kruskal-Wallis H test was used for comparison between multiple groups. The chi-square test was used for comparison of categorical data between two groups. A logistic regression analysis was used to screen out the influencing factors for poor prognosis. ResultsA analysis of the previous medication history of NAs and the mutation patterns for all patients suggested that the patients with the medication history of multiple NAs tended to have multisite mutations and multi-drug resistance (χ2=4295, P<0.05). The level of HBV DNA at the time of virological breakthrough was lower than that at the time of initial administration of NAs in the rtA181V/T mutation group [(6.22±1.48) log10 IU/ml vs (7.08±1.59) log10 IU/ml, t=3.098, P=0.002] and the rtA181V/T+rtN236T mutation group [(5.94±1.45) log10 IU/ml vs (6.94±1.61) log10 IU/ml,t=2.850, P=0.004]. At week 48 of ETV rescue treatment, there were no significant differences between the three groups in HBV DNA negative conversion rate (83.3% vs 82.2% vs 81.6%, P>0.05) and HBeAg negative conversion rate (22.2% vs 17.8% vs 21.1%, P>0.05), and there were also no significant differences in alanine aminotransferase normalization rate (77.1% vs 85.2% vs 83.3%, P>0.05), aspartate aminotransferase normalization rate (80.4% vs 75.9% vs 76.0%, P>0.05), and total bilirubin normalization rate (80.8% vs 79.3% vs 78.1%, P>0.05). HBV DNA level at the beginning of ETV treatment was the risk factor for the treatment outcome of 48-week antiviral therapy (odds ratio = 1.655, 95% confidence interval: 1.128-2.428, P=0.01). ConclusionETV has a good antiviral effect in treatment-experienced CHB patients with rtA181 drug-resistance mutation, and HBV DNA level at the initiation of ETV treatment can predict the outcome of 48-week ETV rescue treatment.
Beh?et's disease complicated with tendinopathy: report of 2 cases with literature review / 中华风湿病学杂志
Haozhong HOU; Xinyu YANG; Siyu FU; Yurui ZHANG; Jinhui LU; Ying ZHANG; Liping WANG.
Chinese Journal of Rheumatology ; (12): 540-543, 2020.
Objective:To explore the possible related factors of Beh?et's disease complicated with tendinitis, in order to better understand the etiology and development mechanism so to guide clinical diagnosis and treatment.Methods:The clinical data of patients with Beh?et's disease complicated with tendonitis treated at Department of Rheumatology and Immunology of Lanzhou University Second Hospital from October 2018 to September 2019 were retrospectively reviewed and related literature were reviewed.Results:Two patients were diagnosed as Beh?et's disease. Foot pain occurred during the treatment. Ultrasound showed tendonitis, and the corresponding treatment relieved the symptoms.Conclusion:Tendons may be involved and presents as a chronic change in patients with Beh?et's disease. In patients with rheumatic diseases, attention should be paid to the correlation between the disease and tendonitis. Aggressive treatment can prevent adverse consequences.
Effects of different anesthesia methods on postoperative analgesia, short-term cognitive function and deep venous thrombosis in patients undergoing hip replacement / 中国基层医药
Liping WANG; Weiting ZHANG.
Chinese Journal of Primary Medicine and Pharmacy ; (12): 2063-2067, 2020.
Objective:To compare the effects of different anesthesia methods on postoperative analgesia, short-term cognitive function and deep venous thrombosis(DVT) in patients undergoing hip replacement.Methods:From March 2017 to March 2019, 96 patients with hip replacement were divided into group A (48 cases) and group B (48 cases) according to the random digital table method.Epidural anesthesia was used in group A, and general anesthesia was used in group B. The perioperative conditions, anesthesia effect, visual analogue scale (VAS) at postoperative 3, 12 and 24 hours, postoperative cognitive dysfunction (POCD) and DVT at postoperative 1, 3 and 7 days were compared between the two groups.Results:The operation time, intraoperative bleeding volume and time to get out of bed between the two groups had no statistically significant differences (all P>0.05). The recovery time[(14.98±2.31)min]and extubation time[(17.35±3.54) min]of group A were faster than those of group B[(19.13±3.42)min and (22.18±2.87)min]( t=6.967, 7.343, all P<0.05). The VAS scores of group B at postoperative 3 h[(3.27±0.73)points], postoperative 12 h[(2.45±0.38)points]and postoperative 24 h[(1.98±0.45)points]were higher than those of group A[(2.34±0.56)points, (1.65±0.43)points and (1.07±0.31)points]( t=7.003, 9.659, 11.538, all P<0.05). The incidences of POCD in group A at postoperative 3d(10.42%) and 7d(2.08%) were lower than those in group B (33.33% and 14.58%) (χ 2=7.357, 3.909, all P<0.05). The incidences of DVT in group A at postoperative 3d(4.17%) and 7d(8.33%) were lower than those in group B (20.83% and 29.17%) (χ 2=7.357, 3.909, all P<0.05). Conclusion:Epidural anesthesia is superior to general anesthesia in hip replacement.Postoperative analgesia is superior to general anesthesia, and can reduce the occurrence of short-term POCD and DVT, which is worthy of clinical reference.
Causes of early death in children after congenital heart surgery / 中国小儿急救医学
Liping WANG; Mingjie ZHANG; Xi CHEN; Jiwen XIONG; Zhuoming XU.
Objective:To explore the causes of death after congenital heart surgery, which may be benefit for improving postoperative outcome of children with congenital heart disease (CHD).Methods:All cases of in-hospital mortality from 2013 to 2018 were collected to analyze the epidemiological characteristics of mortality and causes of death.Results:The mortality showed a downtrend over the past 6 years, from 2.2% in 2013 to 1.2% in 2018.Of all the cases, 72.0% children died under the age of one year old.The death mainly occurred within one week postoperatively (254, 73.2%), especially during the first (101, 29.1%) and the second (51, 14.7%) days.The main cause of death was residual or remained anatomy issues (103, 29.7%), followed by arrhythmia (66, 19.0%) and pulmonary hypertension (57, 16.4%). The incidence of heart failure ( P=0.048) and pulmonary hypertension( P<0.001) in children with functional single ventricle was higher than that in biventricular patients. Conclusion:With the progress of surgical technology and cardiopulmonary bypass, and the improvement of postoperative management, early death after the open-heart surgery for CHD decreased year by year.Postoperative residual or remained anatomy issues was the main cause of death, and the management of it should be strengthened in clinic, especially in children under one year old.
Effect of tea polyphenols in bone tissue cells and its application progress in tissue engineering / 国际生物医学工程杂志
Zhen CAO; Guangyu PAN; Liping WANG; Yong GUO.
International Journal of Biomedical Engineering ; (6): 239-243, 2020.
Bone tissue plays an important role in maintaining physical activity and health. The study of the biological functions of bone tissue cells and their application in tissue engineering is of great significance for clinical prevention and treatment of orthopedic-related diseases. Tea polyphenols are the main components of tea, with natural antioxidant, scavenging free radical activity and anti-inflammatory effects. Research results indicated that tea polyphenols can promote the bone remodeling process mainly by enhancing the formation of osteoblasts and reducing the occurrence of osteoclasts. In addition, tea polyphenols can also be used as surface modification molecules of artificial bone materials and are widely used in the field of bone tissue engineering. In this paper, the regulatory effects of tea polyphenols in bone tissue cells and its application in tissue engineering were reviewed, and related research contents were summarized and prospected, in order to provide reference and theoretical basis for subsequent research work.
Hemodynamic Characteristics of Pulmonary Arterial Hypertension Related to Congenital Heart Disease / 医用生物力学
Liping WANG; Jinlong LIU; Mingjie ZHANG; Juanya SHEN; Zhirong ONG; Zhuoming XU.
Journal of Medical Biomechanics ; (6): E276-E283, 2020.
Objective Hemodynamic disorder of the pulmonary artery (PA) is the main cause of pulmonary arterial hypertension related to congenital heart disease (PAH-CHD). To study the hemodynamic characteristics of PA, so as to understand biomechanical factors in the occurrence and development of PAH-CHD. Methods Clinical and imaging data were collected in five PAH-CHD patients and five matched controls (Non-PAH) to reconstruct subject-specific three-dimensional (3D) PA models. Computational fluid dynamics (CFD) was performed to compare the hemodynamic difference of flow patterns, wall shear stress (WSS) and normalized energy loss (E·) in the two groups. Results Hemodynamics-related parameters showed that the velocity and WSS were higher in the left and right PA branches of PAH-CHD patients, with significantly lower WSS in the main PA. The E· significantly increased in PAH-CHD patients and positively correlated with normalized PA diameter and inflow. Conclusions Compared with Non-PAH subjects, PAH-CHD patients have obviously higher velocity and WSS in PA branches, lower WSS in main PA and greater E·, indicating these hemodynamic parameters are related with the PAH-CHD, which can be used as potential biomechanical factors for the clinical evaluation of PAH-CHD.
Research Progress on Computational Hemodynamics of Pulmonary Hypertension / 医用生物力学
Liping WANG; Mingjie ZHANG; Jinlong LIU; Zhuoming XU.
Pulmonary hypertension (PH) is a devastating disease caused by different etiology and characterized by the progressive elevation of pulmonary vascular resistance and pulmonary artery pressure. As a new method that applied to clinical studies, computational fluid dynamics (CFD) gradually becomes a powerful tool for in-depth understanding of the disease progression. It can noninvasively obtain the patient-specific hemodynamic parameters at any point of the vessel and present them through the visualization technology. In this paper, an overall review of CFD with the focus on PH, including the numerical simulation method, boundary conditions, blood characteristics and relevant hemodynamic parameters was presented.
Clinical features of Caroli disease: An analysis of 41 cases / 临床肝胆病杂志
Yanfei CUI; Simiao YU; Miao TIAN; Xiuxiu SANG; Lifu WANG; Yongqiang SUN; Jing JING; Zhongxia WANG; Liping WANG; Wentao XU; Ruilin WANG.
Journal of Clinical Hepatology ; (12): 2261-2265, 2020.
ObjectiveTo investigate the clinical features of patients with Caroli disease. MethodsThe clinical data were collected from 41 patients who were diagnosed with Caroli disease in The Fifth Medical Center of Chinese PLA General Hospital from April 2015 to January 2020, and the patients were divided into type I group with 16 patients and type Ⅱ group with 25 patients. A retrospective analysis was performed for general information, laboratory markers, and clinical features. The independent samples t-test was used for comparison of normally distributed continuous data between groups, and the Mann-Whitney U test was used for comparison of non-normally distributed continuous data between groups; the chi-square test was used for comparison of categorical data; a Spearman correlation analysis was also performed. ResultsThe type Ⅰ group had a significantly higher level of albumin (Alb) than the type Ⅱ group (t=0.976, P=0.048), and the type Ⅱ group had a significantly higher prothrombin time (PT) than the type I group (Z=3.115, P=0.001). Compared with the type I group, the type Ⅱ group had significantly higher incidence rates of esophageal and gastric varices, upper gastrointestinal bleeding and/or tarry stool, and portal hypertension (χ2=6.077, 5.468, and 2.403, P=0.002, 0.019, and 0.028). In the patients with type Ⅱ Caroli disease, the level of cholinesterase was negatively correlated with the incidence rates of esophageal and gastric varices and portal hypertension (r=-0.468 and -0.436, P=0.018 and 0.029); Alb level was negatively correlated with the incidence rate of esophageal and gastric varices (r=-0.561, P=0.004); red blood cell count was negatively correlated with the incidence rates of esophageal and gastric varices, upper gastrointestinal bleeding and/or tarry stool, and portal hypertension (r=-0.662, -0.566, and -0.436, P<0.001, P=0.003, and P=0.029); hemoglobin count was negatively correlated with the incidence rates of esophageal and gastric varices, upper gastrointestinal bleeding and/or tarry stool, and portal hypertension (r=-0.605, -0.590, and -0.510, P=0.001, 0.002, and 0.009); PT was positively correlated with the incidence rates of esophageal varices and portal hypertension (r=0.488 and 0.520, P=0.013 and 0.008). ConclusionCompared with the patients with type I Caroli disease, the patients with type Ⅱ Caroli disease have a higher incidence rates of esophageal and gastric varices, upper gastrointestinal bleeding and/or tarry stool, and portal hypertension, with the changes in clinical indicators such as the decrease of Alb level and the increase of PT level, and they tend to have poor prognosis.
Clinical features and changing trend of elderly patients with drug-induced liver injury in The Fifth Medical Center of Chinese PLA General Hospital from 2009 to 2019 / 临床肝胆病杂志
Liping WANG; Tingting1b HE; Yanfei CUI; Zhongxia WANG; Jing JING; Lifu WANG; Yun ZHU; Yongqiang SUN; Wentao XU; Simiao YU; Xiuxiu SANG; Miao TIAN; Yuebo REN; Ruilin WANG.
ObjectiveTo investigate the features and changing trend of drug-induced liver injury (DILI) in the elderly from 2009 to 2019, and to provide a reference for clinical prevention and treatment of DILI in the elderly. MethodsA retrospective analysis was performed for the clinical data of 2107 elderly patients, aged ≥60 years, who were diagnosed with DILI in The Fifth Medical Center of Chinese PLA General Hospital from January 2009 to December 2019, and they were divided into groups according to age. Related clinical data were analyzed, including age, sex, clinical features, prognosis, and regional distribution. The Chi-square test was used for comparison of categorical data between groups. ResultsAmong the 2107 patients with DILI, there were 802 male patients and 1305 female patients, with a male/female ratio of 1∶1.63. Cholestasis type was the most common clinical type and was observed in 1439 patients (68.3%). There was the highest number of patients in the 60-64 years group (942 patients, 44.7%), among whom 618(65.6%) were female, 589(62.5%) had cholestasis type, 471(50.0%) had chronic DILI, 421(44.7%) had drug-induced liver cirrhosis, and 25(2.7%) had drug-induced liver failure. There were 187 patients in the 75-79 years group, among whom 110 (58.8%) patients were male, 137(73.3%) had cholestasis type, 114(60.9%) had liver cirrhosis, 4(2.1%) had drug-induced liver failure. The results showed that chronic DILI was more common in the 60-64 years group, and liver cirrhosis was more common in the 75-79 years group. As for prognosis, in the 60-64 years group, 27 patients (2.9%) were cured, 885 (93.9%) were improved, 30(32%) had no response or died; in the 65-69 years group, 16 (2.8%) were cured, 528 (92.0%) were improved, and 30(5.2%) had no response or died; in the 70-74 years group, 9(2.8%) were cured, 305(94.1%) were improved, and 10 (3.6%) had no response or died. The results showed that there was no significant difference in mortality rate between the different age groups (P>0.05). The proportion of elderly DILI patients among hospitalized DILI patients increased from 15.90% in 2009 to 22.05% in 2013 and 27.51% in 2019, with a 1.73-fold increase in 11 years. As for regional distribution, the patients in North China accounted for the highest proportion of 47.08% (the patients from Hebei, Shanxi, and Inner Mongolia accounted for 24.92%, 10.96%, and 10.25%, respectively), followed by those in Northeast China who accounted for 17.85%. The patients in Beijing accounted for 11.53%. ConclusionThe proportion of elderly DILI patients among hospitalized DILI patients tends to increase in these years. Cholestasis type is the most common clinical type, and most of the patients with this clinical type progress to chronic DILI and drug-induced liver cirrhosis. Early diagnosis, early intervention, and standardized treatment of elderly DILI should be taken seriously.
Analysis of SCI journals and research directions of the First Affiliated Hospital of Sun Yat-sen University based on bibliometrics / 中华医学科研管理杂志
Liping WANG; Haifeng LIN; Zhanyong CHEN; Zhuoqing WANG.
Chinese Journal of Medical Science Research Management ; (4): 137-140, 2020.
Objective:To investigate the journals and research directions of SCI papers published by the first affiliated hospital of Sun Yat-sen university from 2007 to 2016. To further study the trend of published journals, as well as the relationship between the research directions and departments.Methods:According to the data from Institute of Scientific and Technical Information of China and the Web of Science, SCI papers of our hospital from 2007 to 2016 were searched and collected, detailed information on published journals and research directions of the papers were analyzed.Results:From 2007 to 2016, scientists of our hospital published 2 999 SCI papers in 897 kinds of journals in total, among which almost 60% papers were published in 166 kinds of journals. PLoS One published the largest number, counted as 125 papers. There were 16 kinds of journals with impact factor (IF)> 10, published 25 papers from 12 departments. A total number of 76 research directions were involved in all these papers, and the largest number of papers was in oncology, accounted for 10.3%. There were 1 647 papers in the top 10 research directions, accounted for 54.92%. Among the 76 research directions, 62 research directions involved more than 2 departments.Conclusions:The distribution of SCI journals published by the first affiliated hospital of Sun Yat-sen university is centralized, with few high-impact achievements. Interdisciplinary research is common and widespread, but the degree of concentration is not enough.
Analysis of epidemiological characteristics of report cases of rotavirus diarrhea in children under 5 years old in China, 2005-2018 / 中华预防医学杂志
Hongmei LUO; Lu RAN; Ling MENG; Yiyao LIAN; Liping WANG.
Chinese Journal of Preventive Medicine ; (12): 181-186, 2020.
Objective@#To analyze the epidemiological characteristics of rotavirus in children under 5 years old in China (excluding China Hong Kong, Macau and Taiwan data, the same below) from 2005 to 2018.@*Method@#Data on other infectious diarrhea in the country from 2005 to 2018 were downloaded from the National Notifiable Disease Report System was to build a database for report cases of rotavirus diarrhea in children under 5 years of age, and descriptive epidemiological methods were used to analyze the data.@*Result@#In 2005-2018, a total of 820 588 cases of rotavirus infection in children under 5 years old were reported nationwide, with male 500 944 cases, and with an average annual incidence of 63.7/100 000. The reported incidence showed a fluctuating upward trend increased from 8.4/100 000 to 178.1/100 000. The number of reporting provinces increased from 17 to 30. The reported incidence showed a peak of season from November to following February. The reported cases of rotavirus diarrhea in children under 5 months of age was 13.1%(107 845 cases), and the high-incidence age ranged from 6 months to 2 years old, accounting for 70.3% (576 874 cases), with a peak of 11-13 months (163 947 cases). The top three provinces (cities) reporting the incidence rate were Zhejiang (535.2/100 000), Guangdong (334.3/100 000) and Beijing (317.3/100 000), the provinces with the low reported case rates were Shanxi (0.9/100 000), Heilongjiang (1.6/100 000) and Liaoning (2.5/100 000), but there was no case reported in Tibet; The report cases of south region (745 526 cases) were 9.9 times north region (74 935 cases).The cases of rotavirus infection and other diarrhea pathogens were detected simultaneously accounted for 1.8% (15 030 cases) and mainly were positive for rotavirus and adenovirus (90.1%, 13 544 cases).@*Conclusion@#The rate of rotavirus infection in children has increased rapidly since the age of 6 months, and 84.4% of the reported cases were infants before the age of 2 years.
Analysis of intestinal flora in patients with chronic rhinosinusitis based on highthroughput sequencing / 南方医科大学学报
Jiayu HUANG; Liping WANG; Xiaoqin WU; Huanjun CHEN; Xiuli FU; Shaohua CHEN; Tao LIU.
Journal of Southern Medical University ; (12): 1319-1324, 2020.
OBJECTIVE@#To investigate the changes in diversity, relative abundance and distribution of intestinal flora in patients with chronic rhinosinusitis and nasal polyps (CRSwNP) using high-throughput sequencing technology identify the intestinal flora significantly related to pathogenesis and progression of CRSwNP.@*METHODS@#Ten patients with CRSwNP hospitalized in the Department of Otolaryngology-Head and Neck Surgery of Guangdong Provincial People's Hospital were selected as the case group with 10 healthy volunteers recruited in the same period as the control group. Fecal genomic DNA extraction kit was used to extract the DNA in the fecal samples, and the DNA fragment length was measured and quantified. The V3 and V4 highly variable regions of the 16S rDNA gene of prokaryotes were amplified followed by library construction, Illumina MiSeq sequencing, sequence alignment and species identification analysis. The relative abundance, diversity and distribution characteristics of the intestinal flora were analyzed, and the relevant metabolic pathways were predicted.@*RESULTS@#Compared with the control group, the patients with CRSwNP had significant changes in the overall structure of the intestinal flora, highlighted by increased abundance of Saccharopolyspora and decreased contents of , , and . Among the metabolic pathways predicted to be associated with CRSwNP, 9 showed significant changes in patients with CRSwNP as compared with the control group ( < 0.05).@*CONCLUSIONS@#Patients with CRSwNP have significant changes in the structural characteristics of intestinal flora related with multiple metabolic pathways, and these changes may play an important role in the development of chronic rhinosinusitis.
Emergency management for kidney transplantation in the epidemic period of coronavirus disease 2019 / 中南大学学报(医学版)
Chunhua FANG; Liping WANG; Manhua NIE; Yajie LIU; Jin HUANG; Xubiao XIE.
Journal of Central South University(Medical Sciences) ; (12): 495-500, 2020.
Article in English | WPRIM | ID: wpr-827396
OBJECTIVES@#To summarize the emergency management of the kidney transplantation for a large tertiary first-class hospital in response to the epidemic of coronavirus disease 2019 (COVID-19).@*METHODS@#The clinical data of inpatients in the Department of Kidney Transplantation from January 24, 2020 to February 29, 2020 were retrospectively analyzed. Since the outbreak of COVID-19, we conducted telephone, Wechat follow-up, and online education for kidney transplant recipients and patients on waiting-list for kidney transplantation one by one. We also strictly screened for COVID-19 in outpatients. To guarantee the security of medical staff and recipients and to reduce the transmission risk of COVID-19, we have made detailed approaches to prevent COVID-19, which mainly included 6 aspects of preventive approaches, such as kidney transplant clinic, kidney transplant ward, patients on waiting-list for kidney transplantation, kidney transplant operation, medical staff self-protection, and postoperative follow-up of kidney transplant recipients.@*RESULTS@#There were altogether 47 inpatients which included 20 recipients who had just received kidney transplantation in the meantime, 2 577 kidney transplant recipients, 1 689 patients on waiting-list for kidney transplantation, and 794 outpatients in our hospital. No case of COVID-19 occurred in this period.@*CONCLUSIONS@#Through strictly implementing proactive and preventive approaches, we avoid the occurrence of COVID-19 in carrying out kidney transplantation in the epidemic period.
Betacoronavirus , Coronavirus Infections , Epidemiology , Humans , Kidney Transplantation , Pandemics , Pneumonia, Viral , Epidemiology , Retrospective Studies , Tertiary Care Centers , Transplant Recipients , Waiting Lists
Impaired Parahippocampal Gyrus-Orbitofrontal Cortex Circuit Associated with Visuospatial Memory Deficit as a Potential Biomarker and Interventional Approach for Alzheimer Disease / 神经科学通报·英文版
Lin ZHU; Zan WANG; Zhanhong DU; Xinyang QI; Hao SHU; Duan LIU; Fan SU; Qing YE; Xuemei LIU; Zheng ZHOU; Yongqiang TANG; Ru SONG; Xiaobin WANG; Li LIN; Shijiang LI; Ying HAN; Liping WANG; Zhijun ZHANG.
Neuroscience Bulletin ; (6): 831-844, 2020.
The parahippocampal gyrus-orbitofrontal cortex (PHG-OFC) circuit in humans is homologous to the postrhinal cortex (POR)-ventral lateral orbitofrontal cortex (vlOFC) circuit in rodents. Both are associated with visuospatial malfunctions in Alzheimer's disease (AD). However, the underlying mechanisms remain to be elucidated. In this study, we explored the relationship between an impaired POR-vlOFC circuit and visuospatial memory deficits through retrograde tracing and in vivo local field potential recordings in 5XFAD mice, and investigated alterations of the PHG-OFC circuit by multi-domain magnetic resonance imaging (MRI) in patients on the AD spectrum. We demonstrated that an impaired glutamatergic POR-vlOFC circuit resulted in deficient visuospatial memory in 5XFAD mice. Moreover, MRI measurements of the PHG-OFC circuit had an accuracy of 77.33% for the classification of amnestic mild cognitive impairment converters versus non-converters. Thus, the PHG-OFC circuit explains the neuroanatomical basis of visuospatial memory deficits in AD, thereby providing a potential predictor for AD progression and a promising interventional approach for AD.
Research progress of anxiety and depression in adult patients undergoing cardiac surgery / 中国胸心血管外科临床杂志
Liping WANG; Yongnan LI; Xiaofeng LU; Xu WANG; Debin LIU; Bingren GAO.
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery ; (12): 574-578, 2020.
@#Anxiety is a strong behavioral and psychological reaction with fear components, while depression is a mental disorder dominated by high or low mood, both of which are accompanied by cognitive and behavioral changes, and are common comorbidities in patients with heart disease. Cardiac surgery is one of the important factors which trigger specific emotional and physiological reactions of patients. Persistent or initial depression and anxiety after surgery will not only increase surgical complications, short- or long-term mortality and medical costs, but also seriously affect patients' social function and quality of life. With the transformation of bio-psycho-social medical model, it is necessary to evaluate the perioperative psychological state and biological risk of patients undergoing cardiac surgery. This article reviews the characteristics, related mechanisms and therapeutic interventions of anxiety and depression in patients undergoing cardiac surgery.
Trichostatin A up-regulates coxsackievirus-adenovirus receptor (CAR) expression through inhibiting MAPK/ERK pathway to enhance the antitumor activity of H101 virus in thymic carcinoma / 中华微生物学和免疫学杂志
Zhanfeng HE; Wei WANG; Tianliang ZHENG; Donglei LIU; Yang YANG; Dengyan ZHU; Kai WU; Liping WANG; Song ZHAO.
Chinese Journal of Microbiology and Immunology ; (12): 628-634, 2020.
Objective:To investigate the expression of coxsackievirus-adenovirus receptor (CAR) in thymic carcinoma and the relationship between CAR and the antitumor activity of oncolytic adenovirus H101.Methods:The expression of CAR in thymic carcinoma tissues and cells were detected by RT-qPCR and Western blot. H101 expression and virus titers in Bcap-37, MP59 and T1889 cells after infection were detected by RT-qPCR and 50% tissue culture infectious dose (TCID 50). The proliferation activity and apoptosis rates of T1889 cells infected with H101 at different multiplicity of infection (MOI) were detected by CCK-8 and flow cytometry. CAR expression in T1889 cells treated with different concentrations of trichostatin A (TSA), a histone deacetylase inhibitor, was detected. H101 expression and virus titers in the TSA-treated and H101-infected cells were detected. Cell activity was detected by CCK-8. The phosphorylation levels of MARK and ERK1/2 and the expression of CAR at protein level in TSA-treated or TSA+ TBHQ (ERK activator) treated cells were detected. Results:CAR expression at both mRNA and protein levels were significantly lower in thymic carcinoma tissues than in adjacent normal tissues ( P<0.01), and lower in MP59 and T1889 cells than in thymic epithelial cells (TEC) and Bcap-37 cells ( P<0.01). H101 expression in MP59 and T1889 cells and the titers of H101 in culture supernatants were significantly lower than those in Bcap-37 cells ( P<0.01). Compared with Bcap-37 cell, the activity of MP59 and T1889 cells was significantly increased and the apoptosis rates were significantly decreased 48 h after H101 infection ( P<0.01). The expression of CAR at both mRNA and protein levels in T1889 cells treated with different concentrations of TSA increased in a dose-dependent manner. When T1889 cells were treated with 0.25 μmol/L of TSA, the expression of H101 at mRNA level and H101 titers were significantly increased ( P<0.05); the phosphorylation levels of MAPK and ERK1/2 proteins were continuously decreased; the expression of CAR was continuously increased. Compared with the TSA treatment group, the expression of CAR at protein level in the TSA+ TBHQ treatment group decreased significantly ( P<0.01), and the p-ERK1/2/ERK1/2 ratio increased significantly ( P<0.01). Conclusions:TSA could up-regulate CAR expression in thymic carcinoma by inhibiting the MARK/ERK1/2 pathway, thereby enhancing the antitumor activity of H101.
Role of ROS/Nrf2 signaling pathway in desflurane preconditioning-induced reduction of lipopolysaccharide-induced acute cerebral inflammation in rats / 中华麻醉学杂志
Haiyan XUE; Zhaokai ZENG; Guozhong CHEN; Liping WANG.
Chinese Journal of Anesthesiology ; (12): 741-746, 2020.
Objective:To evaluate the role of reactive oxygen species (ROS) /nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway in desflurane preconditioning-induced reduction of lipopolysaccharide (LPS)-induced acute cerebral inflammation in rats.Methods:One hundred and twenty clean-grade healthy male Sprague-Dawley rats, aged 8-10 weeks, weighing 200-250 g, were divided into 4 groups ( n=30 each) using a random number table method: control group (group C), LPS-induced acute cerebral inflammation group (group L), desflurane preconditioning group (group D), and N-acetylcysteine plus desflurane preconditioning group (group ND). LPS 1 mg/kg was injected via the tail vein to establish the model of acute cerebral inflammation in L, D and ND groups.In group D, rats inhaled 8.2% desflurane for 1 h once a day for 5 consecutive days, and LPS was intravenously injected at 24 h after the end of the 5th inhalation.In group ND, ROS scavenger N-acetylcysteine 150 mg/kg was intraperitonealy injected at 30 min before each inhalation of desflurane, and the other treatments were similar to those previously described in group D. The expression of Nrf2 and kelch-like ECH-associated protein 1 (Keap1) in microglia and astrocytes in the hippocampal CA1 region was determined by immunofluorescence double staining before LPS injection (at 24 h after the last desflurane preconditioning). Morris water maze test was used to measure the escape latency, space exploration time spent in the original platform quadrant, and frequency of crossing the original platform at 6, 12 and 24 h after injecting LPS.The expression of NOD-like receptor family pyrin domain containing 3 (NLRP3), apoptosis-associated speck-like protein containing CARD (ASC), caspase-1, interleukin-18 (IL-18) and interleukin-1beta (IL-1β) in microglia and astrocytes in the hippocampal CA1 region was determined by immunofluorescence double staining at 6, 12 and 24 h after injecting LPS.Nissl staining and immunofluorescence were used to count normal neurons and activated microglia and astrocytes in the hippocampus at 24 h after LPS injection. Results:Compared with group C, no significant change was found in the expression of Nrf2 and Keap1 in microglia and astrocytes before LPS injection ( P>0.05), and the escape latency was significantly prolonged, the space exploration time spent in the original platform quadrant was shortened, the frequency of crossing the original platform was decreased, the number of normal neurons was decreased, the number of activated microglia and astrocytes was increased, and the expression of NLRP3, ASC, caspase-1, IL-18 and IL-1β was up-regulated after injecting LPS in group L ( P<0.05). Compared with group L, the expression of Nrf2 was significantly up-regulated, and the expression of Keap1 was down-regulated before injecting LPS ( P<0.05), and the escape latency was shortened, the space exploration time spent in the original platform quadrant was prolonged, the frequency of crossing the original platform was increased, the number of normal neurons was increased, the number of activated microglia and astrocytes was reduced, and the expression of NLRP3, ASC, caspase-1, IL-18 and IL-1β was down-regulated after injecting LPS in group D( P<0.05). Compared with group D, the expression of Nrf2 was significantly down-regulated, the expression of Keap1 was up-regulated before injecting LPS ( P<0.05), and the escape latency was significantly prolonged, the space exploration time spent in the original platform quadrant was shortened, the frequency of crossing the original platform was decreased, the expression of NLRP3, ASC, caspase-1, IL-18 and IL-1β was up-regulated, the number of normal neurons was reduced, and the number of activated microglia and astrocytes was increased after LPS injection in group ND ( P<0.05). Conclusion:ROS/Nrf2 signaling pathway is involved in desflurane preconditioning-induced reduction of LPS-induced acute cerebral inflammation in rats.
Role of OGT in methane-induced alleviation of oxygen-glucose deprivation and restoration injury to rat spinal cord neurons: relationship with Nrf2 expression / 中华麻醉学杂志
Liping WANG; Haiyan XUE; Xiaoming GUO; Guozhong CHEN; Hao XU.
Objective:To evaluate the role of O-linked-β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) in methane-induced alleviation of oxygen-glucose deprivation and restoration (OGD/R) injury to rat spinal cord neurons and the relationship with Nrf2 expression.Methods:The primarily cultured spinal cord neurons of rats were seeded in 6-well plates at a density of 1×10 5 cells/ml and divided into 6 groups ( n=60 each) using a random number table method: control group (group C), group OGD/R, methane group (group M), and methane plus OGT inhibitor alloxan group (group MA). The medium was replaced with glucose- and serum-free Earle′s salt solution, and the neurons were exposed to 37 ℃ and 5%CO 2-95%N 2 in an incubator for 2 h followed by routine culture to establish the model of OGD/R.In group M, 200 μl methane-saturated saline (final concentration of methane 1.8 mmol/L) was added at oxygen-glucose restoration.Alloxan 8 mmol/L was added at 10 min after oxygen-glucose restoration to inhibit OGT in MA group.At 12 h of oxygen-glucose restoration, the neuronal survival rate, leakage rate of lactic dehydrogenase (LDH) and apoptotic rate of neurons were measured.The expression of OGT and H3K4me3 in Nrf2 promoter was measured by chromatin immunoprecipitation and fluorescent quantitative real-time polymerase chain reaction.Nucleoprotein was extracted for determination of O-GlcNAc glycosylation of RBBP5 (a H3K4 methyltransferase subunit) by immunoprecipitation and Western blot.The spatial proximity of MLL1 subunit of MLL complex to histone H3 was detected by proximity ligation assay.The expression of Nrf2 protein and mRNA was detected by Western blot and quantitative real-time polymerase chain reaction, respectively.The activities of superoxide dismutase (SOD) and catalase (CAT) and malonaldehyde (MDA) concentration were measured by enzyme-linked immunosorbent assay. Results:Compared with group C, the survival rate of neurons was significantly decreased, and the leakage rate of LDH, apoptotic rate and MDA content in supernatant were increased in OGD/R and M groups ( P<0.01). Compared with OGD/R, the survival rate of neurons was significantly increased, the leakage rate of LDH, apoptotic rate and MDA content in supernatant were decreased, the expression of OGT and H3K4me3 in Nrf2 promoter was up-regulated, O-GlcNAc glycosylation and spatial proximity level of MLL1 to histone H3 were increased, the expression of Nrf2 protein and mRNA was up-regulated, and the activities of SOD and CAT were increased in group M ( P<0.01). Compared with group M, the survival rate of neurons was significantly decreased, the leakage rate of LDH, apoptotic rate and MDA concentration were increased, the expression of OGT and H3K4me3 in Nrf2 promoter was down-regulated, O-GlcNAc glycosylation and spatial proximity level of MLL1 to histone H3 were decreased, the expression of Nrf2 protein and mRNA was down-regulated, and activities of SOD and CAT were decreased in group MA ( P<0.05 or 0.01). Conclusion:OGT is involved in methane-induced alleviation of OGD/R injury to rat spinal cord neurons, which is related to up-regulating Nrf2 expression.
Effect of methane on P2X 7R/NLRP3 signaling pathway during inflammatory responses in a rat model of spinal cord ischemia-reperfusion / 中华麻醉学杂志
Zhaokai ZENG; Haiyan XUE; Liping WANG.
Objective:To evaluate the effect of methane on purinergic ion channel type 7 receptor (P2X 7R)/nod-like receptor protein 3 (NLRP3) signaling pathway during inflammatory responses in a rat model of spinal cord ischemia-reperfusion (I/R). Methods:Fifty-four clean-grade healthy male Sprague-Dawley rats, aged 3 months, weighing 350-380 g, were divided into 3 groups ( n=18 each) using a random number table method: sham operation group (group S), spinal cord I/R group (group I/R) and methane group (group M). Rats underwent sham operation in group S. Spinal cord ischemia was induced by occlusion of the thoracic aorta combined with controlled hypotension for 9 min, followed by reperfusion in anesthetized animals in group I/R.Methane-rich saline 10 mg/kg was intraperitoneally administered immediately after onset of reperfusion in group M. Motor sensory deficit index (MSDI) in hind limbs was measured at 12, 24 and 48 h of reperfusion.The L 3-5 segment of spinal cord was removed at 48 h of reperfusion for determination of the number of normal neurons (by Nissl staining), the number of activated microglia and expression of P2X 7R, NLRP3, apoptosis-associated speck-like protein containing CARD (ASC), cysteine-requiring aspartate protease (caspase-1), interleukin-1beta (IL-1β) and IL-18 (by immunofluorescence staining) in anterior and posterior horns of spinal cord. Results:Compared with group S, the MSDI was significantly increased at 12, 24 and 48 h of reperfusion, and the number of normal neurons in anterior and posterior horns of spinal cord was decreased, the number of activated microglia was increased, and the expression of P2X 7R, NLRP3, ASC, caspase-1, IL-1β and IL-18 was up-regulated at 48 h of reperfusion in group I/R ( P<0.01). Compared with group I/R, the MSDI was significantly decreased at each time point of reperfusion, and the number of normal neurons in anterior and posterior horns of spinal cord was increased, the number of activated microglia was decreased, and the expression of P2X 7R, NLRP3, ASC, caspase-1, IL-1β and IL-18 was down-regulated at 48 h of reperfusion in group M ( P<0.05). Conclusion:The mechanism by which methane reduces inflammatory responses is related to inhibiting P2X7R/NLRP3 signaling pathway in a rat model of spinal cord I/R.
au:"Liping WANG"


Description: A diarylquinoline Antitubercular Agent.
Daily Med: SIRTURO is a diarylquinoline antimycobacterial drug indicated as part of combination therapy in adults (>= 18 years) with pulmonary multi-drug resistant tuberculosis (MDR-TB). Reserve SIRTURO for use when an effective treatment regimen cannot otherwise be provided. SIRTURO is not indicated for the treatment of latent, extra-pulmonary or drug-sensitive tuberculosis.


Pretoria High School for Girls is a state-aided school, governed by a School Governing Body, elected by the parents.
We believe that our strength lies in drawing learners from diverse religious, cultural and socio-economic backgrounds.
Throughout the 109 years of our existence, all girls have been given the means to succeed and be involved in all spheres, be they academic, cultural, sport or service.
The school environment is well structured to provide for the optimum development of every girl into an integrated, responsible adult able to make a worthwhile contribution to the broader community, through the fullest realization of her potential.


text:
Q: GEOS version 3.6.1 required for selecting nearest features I'm not being able to deal with this Travis error asking for GEOS version 3.6.1 while trying to run a unit test in a package that is using sf::st_nearest_feature.
GEOS version 3.6.1 required for selecting nearest features

Everything went well with devtools::check or R CMR checks. Travis is apparently loading geos 3.5.0
The package is here.
Travis geos build fail

Travis log error:
── 1. Error: (unknown) (@test-dwp.R#4)  ────────────────────────────────────────
GEOS version 3.6.1 required for selecting nearest features
Backtrace:
  1. genestdwp::dwp(vr = rings, pt = pto_carcass)
 10. sf::st_join(., filter(vr, visib != 0), join = st_nearest_feature)
 12. sf:::join(x, y, ...)
 13. sf:::CPL_geos_nearest_feature(st_geometry(x), st_geometry(y))
══ testthat results  ═══════════════════════════════════════════════════════════
[ OK: 1 | SKIPPED: 0 | WARNINGS: 0 | FAILED: 1 ]
1. Error: (unknown) (@test-dwp.R#4)

RCMD check
-- R CMD check results ------------------------------------ genestdwp 0.1.0 ----
Duration: 1m 18.4s

0 errors v | 0 warnings v | 0 notes v

R CMD check succeeded

This is all new for me. Any help will be very appreciated.

A: It looks like the issue is with the dist in your .travis.yml file. Try changing to xenial for example which is a version of ubuntu which seems to support libgeos-3.7.1.
language: r
cache: packages
latex: false
sudo: true
dist: xenial

redpajama_set_name: RedPajamaStackExchange


text:
Powerful recollections from Michelle Obama's much anticipated memoir, Becoming
Tarla Lambert November 13, 2018
It's been out for only 24 hours, but already Michelle Obama's memoir 'Becoming' has shot to number one on Amazon. It's not hard to see why.
Obama's memoir is full to the brim with emotive recollections from her time as First Lady and her life prior. She reflects on her struggle with infertility, motherhood, feminism, pervasive racism and grappling (beyond measure) with the reality of a Donald Trump presidency.
Below are some of the most powerful moments:
On racism:
Michelle Obama writes that at the time of her husband's presidential candidacy she was "harbouring a painful thought: Barack was a black man in America, after all. I didn't really think he could win."
In an interview with Good Morning America, Obama says that she found it difficult to overcome ingrained skepticism. How could her country ever elect a black man to the highest office?
"I think I did what a lot of black folks were doing," she said. "We were afraid to hope, because it's hard to think that the country which oppressed you could one day be led by you."
Throughout the following years, she, Barack and their two daughters were subjected to countless racist attacks and innuendos. Perhaps the most damaging incident was inflicted upon them by current President Donald Trump. In 2016, Trump led a racially-charged, vitriolic conspiracy claiming Barack Obama held a false birth certificate.
It was a political stunt that Michelle Obama could "never forgive".
"What if someone with an unstable mind loaded a gun and drove to Washington?" she said. "What if that person went looking for our girls? Donald Trump, with his loud and reckless innuendos, was putting my family's safety at risk. And for this I'd never forgive him," she writes.
On fertility struggles
Perhaps her bravest revelation, Michelle Obama admits that at the age of 34 she and her husband were struggling to conceive. The toll this took on her emotionally and physically was immense.
"We were trying to get pregnant and it wasn't going well," she writes. "We had one pregnancy test come back positive, which caused us both to forget every worry and swoon with joy, but a couple of weeks later I had a miscarriage, which left me physically uncomfortable and cratered any optimism we felt."
During her interview on Good Morning America she added, "I felt like I failed because I didn't know how common miscarriages were because we don't talk about them. We sit in our own pain, thinking that somehow we're broken."
The couple went on to seek marriage counselling and also underwent IVF to conceive their two daughters Malia and Sasha.
On Trump's inauguration:
The former FLOTUS "stopped even trying to smile" during Donald Trump's inauguration in 2017 because she was wracked with dismay. "The vibrant diversity of the two previous administrations was gone," she writes.
"Someone from Barack's administration might have said that the optics there were bad, that what the public saw didn't reflect the President's reality or ideals, but in this case, maybe it did. Realising it, I made my own optic adjustment. I stopped even trying to smile."
On supporting Barack through his darkest hour
Following the Sandy Hook elementary school massacre of 2012, in which a gunman murdered 20 students and 6 teachers, "My husband needed me", Obama wrote.
"This would be the only time in eight years that he'd request my presence in the middle of a workday, the two of us rearranging our schedules to be alone together for a moment of dim comfort. Those images were seared permanently into his psyche. I could see in his eyes how broken they'd left him, what this had done already to his faith."
On redefining the role of FLOTUS:
Michelle Obama was not like the other First Ladies before her– strong, capable, intelligent women, sidelined during their husband's presidencies. Instead, she redefined the role of FLOTUS. She actively led policy like the widely successful 'Let's Move' initiative; promoting the importance of children's health and nutrition.
"In the end, as First Lady, this isn't just a policy issue for me. This is a passion. This is my mission. I am determined to work with folks across this country to change the way a generation of kids thinks about food and nutrition," she writes on site.
Michelle Obama had her own vision outside of her husband's presidency and she sought at all times to use her platform to achieve this. Barack Obama put it perfectly when he said:
"The way in which she blended purpose and policy with fun so that she was able to reach beyond Washington on her health care initiatives, on her military family work was masterful."
She continues to be a role model to women across the world in all walks of life.
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Tarla Lambert
Tarla is the publisher of Women's Agenda. She's a politics junkie, writer, commentator and fierce advocate for equality.
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