text:
Keith Hayes, Jason Heuer, Gabriele Wilson, Peter Mendelsund
Saw these in the store this week and loved'em. There's a new series of paperback re-issues of John Fowles novels. The collage for French Lieutenant's Woman is by Eduardo Recife. Ann Beattie is printed on soft touch with deep deboss on the type and ornaments and a super awesome red spot color. Happy Nude Year, everybody!
Houdini, Maf the Dog, Cynic's Guide, and Geometry of Pasta
Happy Holidayz Everybawdy! Boy, BCovAnon has been a lazy ho these past two weeks, drinkin booze and eatin brisket. Thanks for putting put up with us. These gorgeous covers are from a recent trip to my favorite bookstore, 192 Books in Chelsea. Houdini is from Yale Univ Press. Kimberly Glyder designed and illustrated the Marilyn Monroe cover. A Cynic's Guide is designed by the author, Mario DiGiorgio, and Geometry of Pasta is from Quirk. Here are some heartwarming holiday thoughts from A Cynic's Guide:
Posted by Tal at 4:17 PM 8 comments
Posted by Tal at 10:26 PM 3 comments
Ben Gibson, Phaidon, John Gall, Pentagram
I just gotsta unload these beauties - they've been on my mind for a while. The Eagles, (Sterling) is a gorgeous oversized hardcover, with an added bonus - a distressed silver foil all over the type and illustration. And check out the $1 sticker on the Yard Sale Book - printed right on the case.
Charles Brock: Blackout and All Clear
A series of sci-fi time-travelling novels. In Blackout, three travellers from the year 2060 become unexpectedly trapped in 1940. They struggle not only to find their way home but to survive as Hitler's bombers attempt to pummel London into submission. In All Clear the story continues. I love the mathematical pattern coupled with the photos - the pattern is spot gloss.
Ben Wiseman: Running the Books
New from Knopf Doubleday. A Harvard grad considers becoming a rabbi, but opts for a prison librarian job instead, teaching inmates creative writing on the side. Incredible date stamp illustration!
New Penguin Designers: Alex Merto, Eric White, Jim Tierney, Dan Donohue
In honor of tonight's AIGA Penguin75 talk, I'd like to post some covers by the newest designers working in the Penguin Art Deparment, in order of appearance. Alex Merto (The Old Romantic) works under Helen Yentus at Riverhead. Eric White (Fadeaway Girl) and Jim Tierny (Guided Tour) work under Paul Buckley for Viking/Penguin. Dan Donohue (Super Mario) is working under Joe Perez for Portfolio. Super talented and super fun bunch 'o dudez.
Posted by Tal at 3:26 PM 13 comments
John Fontana: Half Empty
New from Doubleday (illustrator name to come). "In this sardonic collection of essays, Rakoff (Don't Get Too Comfortable) plays the role of a naysayer who tries to convince the reader, with humorous asides and sarcastic one-liners, that the world is going to hell in a hand-basket and the nerds and geeks will someday be the globe's financial and political tyrants." (PW)
Kelly Blair: Aurorarama and The Castle in Transylvania
Kelly Blair is rocking the Mellville House with these two gorgeous new books. Aurorarama is a literary sci-fi novel that takes place in 1908. New Venice-"the pearl of the Arctic"-a place of ice palaces and pneumatic tubes, of beautifully ornate carriage-sleds and elegant victorian garb, of long nights and vistas of ice. An ominous black airship hovers over the city, and the Gentlemen (a government organization) are hunting for the author of a radical pamphlet calling for revolt.
Before Bram Stoker's Dracula, Jules Verne, master of science fiction, wrote this eerie tale of the supernatural set in a forgotten valley in the mountains of Transylvania.
In a tiny village, cut off from the outside world, unnatural events are menacing the populace. Apparitions of vampires and zombies terrorize the townsfolk, and they come to believe that the Devil occupies the abandoned castle looming over their town. A visitor to the region, a young count, vows to liberate the town from this thrall-pitting his reason against the forces of evil and superstition. Yet he too must confront the limits of reason when he views, in the depths of the castle, his long-dead love...
This gripping story-a genre-making first-has long been unavailable. Melville House is proud to present it here in a brilliant new translation by award-winning translator Charlotte Mandell.
All descriptions taken from the Melville House website. Thank you, Bunny, for the headz up.
Gregg Kulick: Journal of a UFO Investigator
Viking, 2011. Printed on uncoated paper with deboss on all the rough pen marks - it feels sculpt debossed. "Against the backdrop of the troubled 1960s, this coming-of-age novel weaves together a compelling psychological drama and vivid outer-space fantasy. Danny Shapiro is an isolated teenager, living with a dying mother and a hostile father and without friends. To cope with these circumstances, Danny forges a reality of his own, which includes the sinister "Three Men in Black", mysterious lake creatures with insectlike carapaces, a beautiful young seductress and thief with whom Danny falls in love, and an alien/human love child who-if only Danny can keep her alive-will redeem the planet."
Robin Bilardello and Milan Bozic: Everything Is Going To Be Great
"When she lands a coveted nonpaying, nonspeaking role in a play going on a European tour, Rachel Shukert—with a brand-new degree in acting from NYU and no money—finally scores her big break. And, after a fluke at customs in Vienna, she gets her golden ticket: an unstamped passport, giving her free rein to "find herself" on a grand tour of Europe." - Harper Perennial, 7/10
Ploy Siripant/Joel Holland: The Unnamed
Arresting new paperback, with handwriting by Joel Holland. Gloss with spot matte on the type. The story of a wealthy happily married man with a strange disease that makes him get up at any hour of the day and set out walking as far as he possibly can go before collapsing.
Gray318: Great House
WW Norton, October 2010. Whoa! I can't wait to see this in the stores...will it be uncoated? I first thought this represented a toppling layer cake, then a house, but now that I've read the plot summary it might be more about this:
"...Connecting these stories is a desk of many drawers that exerts a power over those who possess it or have given it away. As the narrators of Great House make their confessions, the desk takes on more and more meaning, and comes finally to stand for all that has been taken from them, and all that binds them to what has disappeared."
Ben Wiseman: The Hilliker Curse
Terrific new cover from Monsieur Wiseman, which I imagine is inspired by film noir titles.
"The year was 1958. Jean Hilliker had divorced her fast-buck hustler husband and resurrected her maiden name. Her son, James, was ten years old. He hated and lusted after his mother and "summoned her dead." She was murdered three months later.
The Hilliker Curse is a predator's confession, a treatise on guilt and on the power of malediction, and above all, a cri de cœur. James Ellroy unsparingly describes his shattered childhood, his delinquent teens, his writing life, his love affairs and marriages, his nervous breakdown, and the beginning of a relationship with an extraordinary woman who may just be the long-sought Her."
John Fontana: The Tower, The Zoo, and the Tortoise
Noticed the US cover yesterday - a very different look from the current offering at Borders. Illustrator name to follow. The UK cover is below...different title, but I think it's the same book. This is supposed to be a very fun almost child-like novel about a Beefeater in the Tower of London who becomes zoomaster to the Queen's menagerie when they become housed on the Tower grounds. I just visited The Tower, and this is fascinating. There are 36 Beefeaters living there- they are retired members of the military who keep the tower safe and lead the tours, telling you all about Anne Bolyn's head being chopped off at the Tower, people being tortured there, and showing you the awesome Queen's Jewels. Anyway, love these covers.
Lucy Knisley: French Milk
Just finished reading this terrific graphic journal, which I read based solely on the cover. Lucy and her mother spend six weeks in a funky Paris apartment for Lucy's 22nd birthday, where Lucy goes through a post-art-school crisis, and recovers with a good helping of her mother's love and vast quantities of French milk. Like the cover, the book combines photographs and comics, sometimes on facing pages, so we're seeing "reality" and its cartoon version right next to it.
Victor Reinganum: Muriel Spark Novels
Recently fell in love with the new Prime of Miss Jean Brodie cover, designed by Robin Bilardello for Harper Perennial using the illustration from the book's first edition. Reinganum illustrated both Spark covers in the early 60s. I might love Brodie because my friend in high school played the lead in a theater camp production when were 14:
"The story of an eccentric Edinburgh teacher who inspires cultlike reverence in her young students, the novel was Spark's best-known work. The novel explores themes of innocence, betrayal, and cold rationality opposed to unchecked emotionalism. The story of Miss Brodie's ultimate downfall is told from the unsympathetic perspective of one of her students.
Ben Pierrat: The Fourth Realm Trilogy
Cool paperback series design at top...I also love the hardcover of the latest book, The Golden City, on the bottom. Not sure who the hardcover deigner is yet. This is a sci-fi/fantasy series where a Big Brother-like corporation watches every person and controls everything without anyone's knowledge. Two brothers, who can both travel around different levels of consciousness, figure out what's going on but become enemies when one of them decides to join the evil company in his quest for power.
Posted by Tal at 10:24 AM 21 comments
Peter Brown: The Curious Garden
Finally got my hands on a copy of this beautiful book, which always stopped me in my tracks when I saw it in a shop window. "One day, a curious boy named Liam is out exploring his drab, gray city when he comes across a struggling garden. He decides to help the plants grow, never imagining what he is starting...""
Gray318: Scarlett Thomas Novels
I saw these magnificent paperbacks in London. They sound like academic fantasy-adventure novels. In Mr Y, the heroine reads a cursed book and can then enter people's consciousnesses undetected. In Tragic Universe, which comes to the US in September, the heroine is asked to review a book that promises eternal life. And in Popco, the earliest to be published, the heroine, a brilliant puzzle-solving toy inventor, attempts to create a new toy craze for teenage girls while trying to solve a centuries-old puzzle left in a locket by her grandfather.
Keith Hayes, Jason Heuer, Gabriele Wilson, Peter M...
Houdini, Maf the Dog, Cynic's Guide, and Geometry ...
New Penguin Designers: Alex Merto, Eric White, Jim...
Kelly Blair: Aurorarama and The Castle in Transylv...
Robin Bilardello and Milan Bozic: Everything Is Go...


Order a single pancake to split with your party for dessert.
Best brunch spot ever, pancakes are unreal!
If chocolate tower French toast bigger than your head sounds nice, go here for breakfast.
They'll give you only one slice of the Chocolate Tower French Toast if you ask for it.
Breakfast burrito. Can't go wrong.
The best breakfast spot in Chicago!
We don't go here frequently, but when we do, I always leave asking "why don't we eat there every weekend?" it's consistently outstanding food, great friendly service and definitely worth the wait!
I was recommended to have the Deconstructed Lobster Roll Benedict, and it was pretty good. Though, next time I'll definitely be trying one of the decadent looking pancake recipes.
French toast and all the Benedicts are so good. Pricey drinks but phenomenal food quality and quantity.
The food and drinks are phenomenal. Be prepared to wait up to an hour for a seat. Service is decent; wish the waitress didn't present the check while I was waiting. But it was well worth it!
White chocolate caramel pretzel pancakes. Do it.
white chocolate, pretzel pancakes are top of my list.
Best brunch in the city.


Division of Life and Pharmaceutical Science and Department of Life Science, Ewha Woman's University, and National Creative Research Initiative Center for Symbiosystem, Seoul 120-750, South Korea.
Symbiotic mutualism with gut microbes occurs in all metazoans, and it is well established that commensal bacteria influence multiple aspects of host gut physiology such as innate immunity and development. However, our understanding of these coevolved interactions between prokaryotes and eukaryotes remains unclear. One mechanism by which commensal bacteria modulate host intracellular signaling pathways in order to avoid excess inflammation has now been determined. In this process, bacterial-induced reactive oxygen species in gut epithelial cells act as key messengers that inhibit the cullin-1–dependent protein degradation machinery, which in turn results in the stabilization of a master negative regulator of inflammation, inhibitor of nuclear factor-κB (IκB). Furthermore, this bacterial-mediated system also appears to be involved in the stabilization of a key developmental regulator, β-catenin. These findings provide new insights into the molecular mechanisms by which commensal microbes shape host cellular physiology.
Stimulation of the production of reactive oxygen species in gut epithelial cells by commensal bacteria dampens the host immune response.


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This program is called "Slide Show for Youtube". It is a program that you can create the professional slideshows for YouTube, fast and easy. Any fotoshow with pictures, music, videos, text can be managed, including animations like turns, zooms, fadings, panoramas etc. Contains timeline with many tracks. AquaSoft SlideShow for YouTube creates and uploads for you every show automatically. This is the full version and completely free to use.


At some point, Jyothika was the top Kollywood actress after her marriage to Suriya. However, she stopped acting for nearly 9 years, and after her children Diya and Dev started going to school, she made a comeback to movies.
Last year, her film 36 Vayadhinile received both critical acclaim and box-office success.
In an interview to this writer some time back, Jyothika had said she was not interested in doing the regular heroine roles and was looking for strong female-oriented subjects.
In the last one year, she has gone through many scripts, including one by noted writer and director Anjali Menon, but the project did not materialise.
The film is being produced by Suriya's 2D Entertainment and the first schedule has already been completed in and around Chennai. The film's director Bramma had earlier made the award winning Kuttram Kadithal, and is known for his strong script sense.
As per sources, Magalir Mattum has Jyothika playing a very powerful role of a documentary filmmaker, who takes up a cause and fights for it. The film also has three other powerful women characters —Urvasi, Bhanupriya and Saranya Ponvannan — in the supporting cast along with Nasser, Livingstone and Paval.
It has music by Ghibran and Manikandan is the cameraman.
Some years back Kamal Haasan had produced a film titled Magalir Mattum (1994) with Revathy, Urvasi and Rohini in the lead. Sources have now revealed that Suriya's 2D Entertainment had sought Kamal's permission to use the title.
The latest buzz is that Suriya will be doing a cameo in the climax scene in the film. Earlier Suriya had done a special appearance in Pasanga 2, a children's film which he had co-produced.
Meanwhile Jyothika and the unit of the film has left for North India and will be shooting in Agra, Ghaziabad and few other small towns in UP. Magalir Mattum is slated for release early next year.
1Magalir Mattum first look: Jyothika plays a documentary filmmaker; Suriya to make cameo?


Phindy's Place is featuring Operation Write Home in honor of our 2nd birthday celebration on their challenge blog! This challenge lasts from today until September 23, 2010.
Phindy's Place Digi Stamps is the creation of children's book illustrator Philomena O'Neill. She has hundreds of charming, well drawn images to choose from, with several lines featuring special characters such as the popular "Mrs. Comfy", "Summer Cuties" and "Sweet & Salty."
Phindy enjoys creating digi stamp images and sees the combination of her ink line drawing and the crafter who colors and embellishes the image to create a unique finished card as a collaboration between two artists.
Here's a link to the Phindy's Place challenge blog so you can play along!
It's wonderful to learn about Phindy's adorable digis and children's books!! Thanks!


text:
Dan Spandau
Associate Research Professor of Dermatology, Dermatology
Emaildspanda@iupui.edu
Aberrant NF-κB activity in HaCaT cells alters their response to UVB signaling
Lewis, D. A., Hengeltraub, S. F., Gao, F. C., Leivant, M. A. & Spandau, D., Aug 2006, In : Journal of Investigative Dermatology. 126, 8, p. 1885-1892 8 p.
Activation of the insulin-like growth factor-1 receptor promotes the survival of human keratinocytes following ultraviolet B irradiation
Kuhn, C., Hurwitz, S. A., Kumar, M. G., Cotton, J. & Spandau, D., 1999, In : International Journal of Cancer. 80, 3, p. 431-438 8 p.
Somatomedin Receptors
IGF Type 1 Receptor
A functional hepatitis B virus X protein produced in insect cells
Spandau, D., Wang, H. G. H., Fraser, M. J. & Lee, C-H., 1991, In : Virology. 185, 2, p. 938-941 4 p.
hepatitis B virus X protein
Nucleopolyhedrovirus
Sf9 Cells
Amphiregulin Overexpression Results in Rapidly Growing Keratinocytic Tumors: An In Vivo Xenograft Model of Keratoacanthoma
Billings, S. D., Southall, M. D., Li, T., Cook, P. W., Baldridge, L., Moores, W. B., Spandau, D., Foley, J. & Travers, J., Dec 2003, In : American Journal of Pathology. 163, 6, p. 2451-2458 8 p.
Heterografts
A new paradigm for the role of aging in the development of skin cancer
Lewis, D. A., Travers, J. & Spandau, D., Mar 2009, In : Journal of Investigative Dermatology. 129, 3, p. 787-791 5 p.
Ultraviolet Rays
A radiation-induced acute apoptosis involving TP53 and BAX precedes the delayed apoptosis and neoplastic transformation of CGL1 human hybrid cells
Mendonca, M., Mayhugh, B. M., McDowell, B., Chin-Sinex, H., Smith, M. L., Dynlacht, J., Spandau, D. & Lewis, D. A., Jun 2005, In : Radiation Research. 163, 6, p. 614-622 9 p.
Hybrid Cells
A system for simultaneous ultraviolet light and electromagnetic field exposure in in vitro experiments
Vesper, D. N., Nindl, G., Johnson, M. T., Spandau, D., Swez, J. A. & Balcavage, W. X., 2001, In : Biomedical Sciences Instrumentation. 37, p. 221-226 6 p.
Both transcriptional regulation and translational control of ATF4 are central to the integrated stress response
Dey, S., Baird, T. D., Zhou, D., Palam, L. R., Spandau, D. & Wek, R., Oct 22 2010, In : Journal of Biological Chemistry. 285, 43, p. 33165-33174 10 p.
Endoplasmic Reticulum Stress
Protein Biosynthesis
Regulator Genes
Characterization of the terminal sequences flanking the transposon that carries the Escherichia coli enterotoxin STII gene
Hu, S. T., Yang, M. K., Spandau, D. & Lee, C-H., 1987, In : Gene. 55, 2-3, p. 157-167 11 p.
heat stable toxin (E coli)
Decreased incidence of nonmelanoma skin cancer in patients with type 2 diabetes mellitus using insulin: A pilot study
Chuang, T. Y., Lewis, D. A. & Spandau, D., Sep 2005, In : British Journal of Dermatology. 153, 3, p. 552-557 6 p.
Degradation of starch and its hydrolytic products by oral bacteria.
Glor, E. B., Miller, C. H. & Spandau, D., Jan 1988, In : Journal of Dental Research. 67, 1, p. 75-81 7 p.
Determination of the promoter strength of the gene encoding Escherichia coli heat-stable enterotoxin II
Spandau, D. & Lee, C-H., 1987, In : Journal of Bacteriology. 169, 4, p. 1740-1744 5 p.
Enterotoxins
Galactosidases
Distinct conformations of p53 are observed at different stages of keratinocyte differentiation
Spandau, D., Jul 1994, In : Oncogene. 9, 7, p. 1861-1868 8 p.
E5 protein of human papillomavirus type 16 protects human foreskin keratinocytes from UV B-irradiation-induced apoptosis
Zhang, B., Spandau, D. & Roman, A., 2002, In : Journal of Virology. 76, 1, p. 220-231 12 p.
Foreskin
Papillomaviridae
Effect of Ultraviolet B Radiation and 100 Hz Electromagnetic Fields on Proliferation and DNA Synthesis of Jurkat Cells
Nindl, G., Hughes, E. F., Johnson, M. T., Spandau, D., Vesper, D. N. & Balcavage, W. X., Sep 2002, In : Bioelectromagnetics. 23, 6, p. 455-463 9 p.
Jurkat Cells
Estrogen modulates mesenchyme-epidermis interactions in the adult nipple
Wu, H. J., Oh, J. W., Spandau, D., Tholpady, S., Diaz, J., Schroeder, L. J., Offutt, C. D., Glick, A. B., Plikus, M. V., Koyama, S. & Foley, J., Apr 15 2017, In : Development (Cambridge). 144, 8, p. 1498-1509 12 p.
Parathyroid Hormone-Related Protein
Evidence for involvement of the epidermal platelet Activating factor receptor in ultraviolet-B-radiation induced interleukin-8 production
Countryman, N. B., Pei, Y., Yi, Q., Spandau, D. & Travers, J., 2000, In : Journal of Investigative Dermatology. 115, 2, p. 267-272 6 p.
Platelet Activating Factor
KB Cells
Expansion of specialized epidermis induced by hormonal state and mechanical strain
Wu, H. J., Easwaran, T., Offutt, C. D., Elgar, R. L., Spandau, D., Koyama, S. & Foley, J., May 1 2015, In : Mechanisms of Development. 136, p. 73-86 14 p.
Relaxin
Expression of the platelet-activating factor receptor results in enhanced ultraviolet B radiation-induced apoptosis in a human epidermal cell line
Barber, L. A., Spandau, D., Rathman, S. C., Murphy, R. C., Johnson, C. A., Kelley, S. W., Hurwitz, S. A. & Travers, J., Jul 24 1998, In : Journal of Biological Chemistry. 273, 30, p. 18891-18897 7 p.
Expression of vimentin in cultured human keratinocytes is associated with cell - extracellular matrix junctions
Biddle, D. & Spandau, D., 1996, In : Archives of Dermatological Research. 288, 10, p. 621-624 4 p.
Cell-Matrix Junctions
Intercellular Junctions
Intermediate Filaments
Keratins
Ex vivo culture of mouse skin activates an interleukin 1 alpha-dependent inflammatory response
Zhou, H. M., Slominski, R. M., Seymour, L. J., Bell, M. C., Dave, P., Atumonye, J., Wright, W., Dawes, A., Griesenauer, B., Paczesny, S., Kaplan, M. H., Spandau, D. F. & Turner, M. J., Jan 1 2019, (Accepted/In press) In : Experimental Dermatology.
Interleukin-1alpha
Chemokine CXCL1
Interleukin-1 Type I Receptors
Fibroblast senescence and squamous cell carcinoma: How wounding therapies could be protective
Travers, J., Spandau, D., Lewis, D. A., Machado, C., Kingsley, M., Mousdicas, N. & Somani, A-K., Jul 2013, In : Dermatologic Surgery. 39, 7, p. 967-973 7 p.
Somatomedins
Fractionated laser resurfacing corrects the inappropriate UVB response in geriatric skin
Spandau, D., Lewis, D. A., Somani, A-K. & Travers, J., Jun 2012, In : Journal of Investigative Dermatology. 132, 6, p. 1591-1596 6 p.
Human Keratinocyte Differentiation Requires Translational Control by the eIF2α Kinase GCN2
Collier, A. E., Wek, R. & Spandau, D., Sep 1 2017, In : Journal of Investigative Dermatology. 137, 9, p. 1924-1934 11 p.
Eukaryotic Initiation Factor-2
Polyribosomes
IL-4 impairs wound healing potential in the skin by repressing fibronectin expression
Serezani, A. P. M., Bozdogan, G., Sehra, S., Walsh, D., Krishnamurthy, P., Sierra Potchanant, E. A., Nalepa, G., Goenka, S., Turner, M. J., Spandau, D. & Kaplan, M., Oct 23 2015, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.
Fibronectins
Important implications and new uses of ablative lasers in dermatology: Fractional carbon dioxide laser prevention of skin cancer
Jagdeo, J. R., Brody, N. I., Spandau, D. & Travers, J., Mar 15 2015, In : Dermatologic Surgery. 41, 3, p. 387-389 3 p.
Radiation-Induced Neoplasms
Inhibition of erbB receptor family members protects HaCaT keratinocytes from ultraviolet-B-induced apoptosis
Lewis, D. A., Zweig, B., Hurwitz, S. A. & Spandau, D., Mar 1 2003, In : Journal of Investigative Dermatology. 120, 3, p. 483-488 6 p.
Protein-Tyrosine Kinases
Insulin-like growth factor-1 receptor regulates repair of ultraviolet B-induced DNA damage in human keratinocytes in vivo
Loesch, M. M., Collier, A. E., Southern, D. H., Ward, R. E., Tholpady, S. S., Lewis, D. A., Travers, J. & Spandau, D., Mar 4 2016, (Accepted/In press) In : Molecular Oncology.
Insulin-like growth factor 1 receptor signaling is required for optimal ATR-CHK1 kinase signaling in ultraviolet B (UVB)-irradiated human keratinocytes
Kemp, M. G., Spandau, D., Simman, R. & Travers, J., Jan 27 2017, In : Journal of Biological Chemistry. 292, 4, p. 1231-1239 9 p.
Automatic teller machines
Keratin 2e: A marker for murine nipple epidermis
Mahler, B., Gocken, T., Brojan, M., Childress, S., Spandau, D. & Foley, J., 2004, In : Cells Tissues Organs. 176, 4, p. 169-177 9 p.
Keratin-2
Loss of the Nf1 Tumor Suppressor Gene Decreases Fas Antigen Expression in Myeloid Cells
Hiatt, K., Ingram, D., Huddleston, H., Spandau, D., Kapur, R. & Clapp, D., Apr 2004, In : American Journal of Pathology. 164, 4, p. 1471-1479 9 p.
CD95 Antigens
Myeloid Cells
Tumor Suppressor Genes
Mast Cells
Stem Cell Factor
Ocular Pathology of Oculocerebrorenal Syndrome of Lowe: Novel Mutations and Genotype-Phenotype Analysis
Song, E., Luo, N., Alvarado, J. A., Lim, M., Walnuss, C., Neely, D., Spandau, D., Ghaffarieh, A. & Sun, Y., Dec 1 2017, In : Scientific Reports. 7, 1, 1442.
Oculocerebrorenal Syndrome
p53-binding proteins in squamous cell carcinoma and normal human keratinocytes
Kumar, M. G. & Spandau, D., 1995, In : Cell Growth and Differentiation. 6, 12, p. 1601-1608 8 p.
Phenotyping acute and chronic atopic dermatitis-like lesions in Stat6VT mice identifies a role for IL-33 in disease pathogenesis
DaSilva-Arnold, S. C., Thyagarajan, A., Seymour, L. J., Yi, Q., Bradish, J. R., Al-Hassani, M., Zhou, H., Perdue, N. J., Nemeth, V., Krbanjevic, A., Serezani, A. P. M., Olson, M. R., Spandau, D., Travers, J., Kaplan, M. & Turner, M. J., Jan 24 2018, (Accepted/In press) In : Archives of Dermatological Research. p. 1-11 11 p.
STAT6 Transcription Factor
Primary cilia signaling mediates intraocular pressure sensation
Luo, N., Conwell, M. D., Chen, X., Kettenhofen, C. I., Westlake, C. J., Cantor, L., Wells, C., Weinreb, R. N., Corson, T., Spandau, D., Joos, K. M., Iomini, C., Obukhov, A. & Sun, Y., Sep 2 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 35, p. 12871-12876 6 p.
Cilia
TRPV Cation Channels
Trabecular Meshwork
Pten loss induces autocrine FGF signaling to promote skin tumorigenesis
Hertzler-Schaefer, K., Mathew, G., Somani, A-K., Tholpady, S., Kadakia, M. P., Chen, Y., Spandau, D. & Zhang, X., 2014, In : Cell Reports. 6, 5, p. 818-826 9 p.
Autocrine Communication
Quantitative analysis of UVB-induced apoptosis in human epidermis
Hurwitz, S. A. & Spandau, D., Jun 2000, In : Experimental Dermatology. 9, 3, p. 185-191 7 p.
Radiation therapy generates platelet-activating factor agonists
Sahu, R. P., Harrison, K. A., Weyerbacher, J., Murphy, R. C., Konger, R., Garrett, J. E., Chin-Sinex, H. J., Johnston, M. E., Dynlacht, J., Mendonca, M., McMullen, K., Li, G., Spandau, D. & Travers, J., Apr 12 2016, In : Oncotarget. 7, 15, p. 20788-20800 13 p.
Regulation of parathyroid hormone-related protein gene expression by epidermal growth factor-family ligands in primary human keratinocytes
Cho, Y. M., Lewis, D. A., Koltz, P. F., Richard, V., Gocken, T. A., Rosol, T. J., Konger, R., Spandau, D. & Foley, J., Apr 2004, In : Journal of Endocrinology. 181, 1, p. 179-190 12 p.
Epidermal Growth Factor
Repression of the hepatitis B virus enhancer by a cellular factor
Spandau, D. & Lee, C-H., 1992, In : Journal of General Virology. 73, 1, p. 131-137 7 p.
Transcription Factor AP-1
Chloramphenicol O-Acetyltransferase
Reversing the aging stromal phenotype prevents carcinoma initiation
Lewis, D. A., Travers, J., Machado, C., Somani, A-K. & Spandau, D., Apr 2011, In : Aging. 3, 4, p. 407-416 10 p.
Skin resurfacing procedures: New and emerging options
Loesch, M. M., Somani, A-K., Kingsley, M., Travers, J. & Spandau, D., Aug 28 2014, In : Clinical, Cosmetic and Investigational Dermatology. 7, p. 231-241 11 p.
Subphysiological concentrations of extracellular calcium sensitize normal human keratinocytes to UVB-induced apoptosis
Kumar, M. G., Hurwitz, S. A., Cotton, J. & Spandau, D., 1999, In : Archives of Dermatological Research. 291, 1, p. 37-46 10 p.
Fluorescein-5-isothiocyanate
The effect of chemexfoliation and anti-aging regiments on fibroblast expression of IGF-1: A pilot Study
Zandifar, H., Lewis, D. A., Spandau, D., Beeson, W. H. & Travers, J., 2011, In : Laryngoscope. 121, SUPPL. 5
Chemexfoliation
The Effect of Phosphorylation on the Antigenic Reactivity of p53 in Cultured Human Keratinocytes
Kumar, M. & Spandau, D., Sep 14 1995, In : Biochemical and Biophysical Research Communications. 214, 2, p. 744-753 10 p.
Epitopes
Phosphoric Monoester Hydrolases
Protein Phosphatase 1
The epidermal platelet-activating factor receptor augments chemotherapy-induced apoptosis in human carcinoma cell lines
Li, T., Southall, M. D., Yi, Q., Pei, Y., Lewis, D., Al-Hassani, M., Spandau, D. & Travers, J., May 9 2003, In : Journal of Biological Chemistry. 278, 19, p. 16614-16621 8 p.
The IGF-1/IGF-1R signaling axis in the skin: A new role for the dermis in aging-associated skin cancer
Lewis, D. A., Travers, J., Somani, A-K. & Spandau, D., Mar 2010, In : Oncogene. 29, 10, p. 1475-1485 11 p.
The platelet-activating factor receptor activates the extracellular signal-regulated kinase mitogen-activated protein kinase and induces proliferation of epidermal cells through an epidermal growth factor-receptor-dependent pathway
Marques, S. A., Dy, L. C., Southall, M. D., Yi, Q., Smietana, E. V. A., Kapur, R., Marques, M., Travers, J. & Spandau, D., 2002, In : Journal of Pharmacology and Experimental Therapeutics. 300, 3, p. 1026-1035 10 p.
Extracellular Signal-Regulated MAP Kinases
Mitogen-Activated Protein Kinases
Epidermal Growth Factor Receptor
The Platelet-activating Factor Receptor Protects Epidermal Cells from Tumor Necrosis Factor (TNF) α and TNF-related Apoptosis-inducing Ligand-induced Apoptosis through an NF-κB-dependent Process
Southall, M. D., Isenberg, J. S., Nakshatri, H., Yi, Q., Pei, Y., Spandau, D. & Travers, J., Dec 7 2001, In : Journal of Biological Chemistry. 276, 49, p. 45548-45554 7 p.
G-Protein-Coupled Receptors
Trans-activation of viral enhancers by the hepatitis B virus X protein
Spandau, D. & Lee, C-H., 1988, In : Journal of Virology. 62, 2, p. 427-434 8 p.
Simian virus 40
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Tag Archives: republican left of catalunya
Catalonia, Spain
Catalonia's post-election future murky as Mas prioritizes power over secession
January 4, 2016 Kevin Lees	Leave a comment
Amid increasing tensions since 2012 between prime minister Mariano Rajoy and regional president Artur Mas, the Catalan independence movement hovers like a dark cloud over the national debate. (Facebook)
In the aftermath of a difficult national election that could well lead to fresh elections across all of Spain, Catalonia, the northeastern region with a swelling independence movement, was always set to be the largest puzzle piece that patches together any potential coalition to lead the national government.
Now the region will take center stage even more fully in Spain's unfolding political drama, with a high-stakes game of chicken reaching its peak this week between regional president Artur Mas and the left-wing Candidatura d'Unitat Popular (CUP, Popular Unity Candidacy). The pro-independence CUP has refused to lend its support to the larger pro-independence coalition, Junts pel Sí (Together for Yes), the broad, pan-ideological group that won last September's elections.
The CUP's leaders have for months maintained that they will not — and politically cannot — support Mas, a center-right regional leader who has skillfully attached himself to a sovereigntist movement that's now dominated by figures on the Catalan left. He's the ideological heir to a political elite that, under his predecessor, Jordi Pujol (regional president from 1980 to 2003), became synonymous with corruption. Moreover, as regional president since 2010, Mas has introduced tax increases and budget cuts designed to keep the region's fiscal condition from deteriorating, even as the wider Spanish economy collapsed, taking the Catalan regional economy with it.
RELATED: Madrid ignores Catalan vote at grave risk
RELATED: Catalan election results: pro-independence parties win narrow majority
RELATED: Three choices for new, fractured Spanish political landscape
On Sunday, the CUP — a radical left group that would oppose an independent Catalonia's membership in either NATO or the European Union — reiterated that it cannot support Mas for regional president and that it will block investiture of Catalonia's executive government, the Generalitat, forcing new spring elections, so long as Mas is determined to lead it. Indeed, Mas has refused to step aside. If no one budges between now and January 10, Catalonia will hold fresh elections (along, perhaps, with Spain after the fractured result of the December 20 national elections). For Catalans, it would be the fourth regional election in five years.
But if there's one thing that Junts pel Sí doesn't lack, it's a deep bench of political leaders, each of whom could easily step in as a regional president far more amenable to the radical CUP and its supporters, thereby forming a truly broad pro-independence front. If Mas doesn't back away in favor of another of his coalition's leaders, fresh elections could actually leave Catalonia's parliament even more divided, potentially setting back the independence movement that he claims to represent. And that should tell you exactly where Mas's heart lies — in maintaining power at all costs, not seriously advancing an independent Catalonia.
By forcing spring elections, Mas risks, first, prolonging the process of building both a national Spanish government and a regional Catalan government, and, secondly, discrediting the independence movement itself. Continue reading Catalonia's post-election future murky as Mas prioritizes power over secession →
ada colauartur mascataloniacatalunyaCDCCiUciudadanosconvergence and unionCUPdemocratic convergenceDiUen comu podemjordi pujoljunquerasjunts pel sipartido popularpedro sanchezpodemosPPPSOErajoyrepublican left of catalunyaromevaspainspanish socialist workers' party
Catalonia, Catalunya, Spain
Catalan election results: pro-independence parties win narrow majority
September 27, 2015 Kevin Lees	Leave a comment
Regional president Artur Mas declares victory in Sunday's Catalan elections.(Reuters/Sergio Pérez)
There's no doubt that the pro-independence Junts pel Sí (Together for Yes) coalition won a resounding victory in Sunday's regional elections in Catalonia. With nearly 40% of the vote, it is by far the largest force in Catalonia's regional government and with the support of the ardently pro-independence, hard-left Candidatura d'Unitat Popular (CUP, Popular Unity Candidacy), it is likely to form a government that will carry forward the cause of Catalan independence over the next 18 months.
For the first time in Catalan history, an explicitly pro-independence coalition, running expressly on the campaign pledge to enact an 18-month process toward declaring independence, will control the Generalitat, the Catalan government.
But that's essentially where the good news ends for Catalonia's independence movement, which now faces the real prospect of hubris and overreach in the days and weeks ahead.
A democratic deficit
The first difficulty is that, though pro-independence parties now control the Catalan parliament, those parties did not, as a technical matter, win a majority of votes in the election. Pro-independence parties together won around 47.9% of the vote, just shy of an outright majority, depriving the pro-independence camp of an important moral victory in its quest. It's difficult to claim that your movement commands democratic support when a majority of voters, in an election with nearly 77.5% turnout, supported anti-independence parties.
It's hard to compare the 2015 result against the 2012 result because that's something of an apples-to-oranges comparison. But in the broadest sense, the parties supporting independence (or at least sympathetic to the cause of Catalan nationalism) won 74 seats in the Catalan parliament. That's actually two more seats than the pro-independence parties won in the 2015 vote.
Continue reading Catalan election results: pro-independence parties win narrow majority →
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Madrid ignores Catalan vote at grave risk
November 11, 2014 Kevin Lees	Leave a comment
Though Sunday's unofficial referendum on Catalan sovereignty may have been legally murky, it is nonetheless clear that Spanish prime minister Mariano Rajoy's strategy of ignoring the groundswell of support for regional self-determination and autonomy has been a failure.
So what actually happened on Sunday — and where do the Catalan nationalist movement and the Spanish government go from here?
What happened in Sunday's 'consultation' vote
Photo credit to AFP.
Catalans voted in a non-binding, unofficial 'consultation' that its Generalitat (or regional government) once hoped would be a legal referendum not unlike the recent September vote on independence in Scotland. But Rajoy has refused to countenance even the idea of negotiating the terms of such a referendum, and he has consistently ruled out any vote as unconstitutional.
Nevertheless, Catalunya's regional president Artur Mas (pictured above) has championed a referendum since at least 2012, and his party and other more radical groups in the Catalan regional parliament overwhelmingly voted to hold the referendum, setting the central and Catalan regional governments on what has been a divisive battle over the past year.
RELATED: Mas cancels official Catalan independence vote
Mas backed down on the 'official' nature of the referendum, which in any event was always designed to be non-binding, when Spain's constitutional court ruled that the vote was illegal last month. Much to the chagrin of other, more leftist nationalists, however, Mas instead moved forward with an unofficial referendum, taking care not to use official Spanish government resources to conduct the vote.
The Spanish constitutional court ruled last week, in a second decision, that even this unofficial, non-binding 'consultation' should be delayed until it could have time to rule on its further legality. Mas went ahead with the vote, anyway, however, prompting a sharp rebuke from Rajoy's government on Sunday:
Justice Minister Rafael Catalá described the November 9 vote as an "act of political propaganda with no democratic validity; a sterile and useless act."
The minister went on to announce that the public prosecutor would evaluate the facts of Sunday's vote and decide whether or not to begin legal action in the courts.
Though the law is squarely on the side of the Spanish government, the Catalans seem to have valid political and moral reasons for demanding at least a voice over their own future. In any event, at least 2.3 million Catalans turned out for the vote, representing around 35% of the total Catalan electorate, nearly all of them were pro-independence voters.
The vote asked two questions: first, 'do you want Catalunya to be a state?' and second, 'if so, do you want Catalunya to be an independent state?'
The so-called 'yes-yes' vote won with around 80.8% of the vote. The so-called 'yes-no' vote (i.e., those supporters of a Catalan state, but not necessarily an independent state) won another 10.1%. 'No' won just 4.5% of the vote.
While that's skewed in favor of the independence movement, it's also not insignificant — and it indicates that a large portion of the Catalan people want a legal and valid vote on their status. The longer that Madrid assumes an ostrich position over what's become a very real sense of grievance among everyday Catalans, the worse the standoff over independence will end. By refusing to discuss the possibility, Rajoy and the central government risk pushing moderate unionists into the arms of the Catalan nationalists.
Nevertheless, Sunday's turnout fell far short of the 3.7 million voters who participated in the most recent November 2012 regional elections, indicating that a substantial number of voters (who presumably aren't as enthusiastic about independence) didn't bother to turn out. The two-pronged ballot question demonstrates the kind of too-cute-by-half ambiguity that British prime minister David Cameron refused to entertain when negotiating the Scottish referendum — what, after all, does it mean for Catalunya to be a state if not independent?
A frustrated electorate trapped between Rajoy and Mas
The most obvious solution to the standoff is a calm, rational conversation between the Mas and Rajoy governments that would result in greater autonomy for Catalunya's Generalitat with respect to its own finances and spending. Incredibly, however, the two leaders went months earlier this year without even talking.
Rajoy, whose center-right Partido Popular (PP, People's Party) won the November 2011 Spanish general elections, has consistently refused to discuss greater autonomy for Catalunya. In part, this is because Rajoy's party has fairly little support within Catalunya — the Partit Popular de Catalunya (PPC, People's Party of Catalonia) is just the fourth-largest bloc in the regional parliament. So Rajoy feels little immediate political pain from snubbing the region.
When he took office, Rajoy faced the likelihood that Spain would be essentially forced into a European bailout. As it turned out, Rajoy was forced into implementing budget cuts and tax increases to stave off a bailout — in addition to similar austerity measures introduced by his predecessor, José Luis Rodríguez Zapatero, the center-left prime minister whose Partido Socialista Obrero Español (PSOE, Spanish Socialist Workers' Party) came to power in 2004 at the dawn of the Spanish construction and finance boom.
Accordingly, Rajoy has a decent argument for avoiding a full-fledged independence referendum: with a 23.7% unemployment rate as of September, Spain is still in the midst of the worst financial and economic crisis in decades. An independence referendum in Catalunya might credibly be followed by a referendum in the Basque Country/Euskadi, another economic powerhouse with an even more painful history of separatism. Copycat movements could thrive in Galicia and elsewhere. So Rajoy has a reasonably sympathetic argument that a Catalan referendum in the midst of the current crisis could eventually pose an existential threat to the Spanish nation.
But that's not an excuse for ignoring the problem. What's worse is that the Spanish economic crisis is itself also fueling greater discontent among Catalans, who believe they send far more in revenue to the Spanish central government than they receive back in services and infrastructure. Though the data isn't entirely clear, the Catalans are essentially correct. It rankles that all high-speed trains in Spain run through Madrid, for example, and that almost all of the country's international flights arrive at the Madrid airport. Catalunya, with just 7.5 million of Spain's 47 million citizens, is responsible for 19% of the economy.
RELATED: In refusing Catalan vote,
Rajoy risks isolating himself and Spain's future
The Scottish referendum was also about economics (nationalists believe they can thrive as a smaller, oil-rich country within the European Union) and about politics (like the PP in Catalunya, the Conservatives have relatively little support in Scotland). But the Catalan movement is also colored by additional layers of complexity that Rajoy shows virtually no sign of appreciating — notably decades of suppression of its language and culture by the dictatorship of Francisco Franco. When Rajoy's education minister, a few years ago, suggested a stronger national program in the Castilian language, it particularly rankled Catalans, many of whom remember the days when the Catalan language was legally banned.
But Mas, the leader of the Convergència i Unió (CiU, Convergence and Union), a two-party, center-right nationalist coalition that's traditionally been the most powerful force in Catalan politics since the return of democracy, is hardly an honest broker. CiU has always been more comfortable with greater autonomy than full independence, and Mas only recently converted to the cause in 2012 following widespread protests. Since taking power in 2010, Mas has made many of the same painful, unpopular budget decisions at the regional level that Rajoy has made at the national level. What's more, Jordi Pujol, the former CiU leader and Catalan president between 1980 and 2003, has been subject of increasing scrutiny over his personal wealth and corruption accusations.
Accordingly, neither Mas nor Rajoy come out of the current showdown from a incredible position of strength. That might not necessarily matter if they could at least find a middle ground to discuss the most sensible solution to the political crisis — constitutional reform, greater regional autonomy and the possible creation of a federalist system in Spain.
As elections loom, what comes next?
So far, however, the chances of any productive talks between Madrid and Barcelona seem small.
Mas has given Rajoy a two-week deadline to begin negotiations for a formal referendum. Rajoy, however, is almost certainly unlikely to take Mas up on that offer.
What happens thereafter is murky, though.
Mas's party, the larger, more moderate and more aggressive Convergència Democràtica de Catalunya (CDC, Democratic Covergence) within the CiU, would like to hold early regional elections, rolling the dice that they would become a de facto referendum on Catalan independence — or at least the right of the Catalan government to call a vote. The smaller, Christian democratic Unió Democràtica de Catalunya (UDC, Democratic Union) has always been less enthusiastic about Mas's push for independence and would prefer to wait on snap elections.
Part of the political calculus for Mas, Rajoy and the CiU are polls that show that the most popular party in Catalunya is now the leftist Esquerra Republicana de Catalunya (ERC, Republican Left of Catalonia), an even more radical pro-independence party led by historian Oriol Junqueras.
On paper, at least, the PP and the CiU have much more in common than the PP and Esquerra, so both Rajoy and Mas have an incentive to reach some kind of face-saving deal in the next few days.
But at the rate Rajoy is going, he may not have the opportunity to negotiate anything in the long run.
The rise of the anti-establishment Podemos ('We can!'), the movement founded earlier this year by professor Pablo Iglesias (pictured above), has scrambled all pretenses of Spain's two-party system. Winning five of the country's seats to the European Parliament in May, Podemos wants to reevaluate Spain's public debt, lower the retirement age to 60 to free up more jobs for younger workers and reverse the austerity of the past two PSOE and PP governments, using government spending to create jobs for a country that still has the highest unemployment within the European Union, despite signs of new growth. A Podemos win would be a significant setback to the orthodox policies that German chancellor Angela Merkel has attempted to establish throughout the eurozone, including the 2011 'fiscal compact' that firmly limits national budget deficits to less than 3% of GDP.
Podemos, in a shock Metroscopia poll a couple weeks ago, gained the lead among potential voters in advance of the next Spanish general election, which must be held before December 2015 — it would win 27.7% to just 26.2% for the PSOE, under the leadership of Pedro Sánchez, who won his party's July leadership contest, and 20.7 for Rajoy's PP. Sánchez, for his part, opposes Catalan independence, but has indicated much greater willingness to hold discussions with regional leaders over constitutional reform.
The local Partit dels Socialistes de Catalunya (PSC-PSOE, Socialists' Party of Catalonia) controlled the regional government between 2003 and 2010, and many of its members are sympathetic to the idea that Catalans should have the right to self-determination.
Though Podemos is widely viewed as a leftist alternative, it has attracted widespread support from many Spaniards who have lost faith in both major parties, especially among young voters who face the worst job prospects, and the indignados, the unemployed protestors who have given voice to the harsh effects of what are now a half-decade of austerity policies.
Ironically, Podemos has attracted little support within Catalunya, where voters have a nationalist (and leftist) alternative in Esquerra.
But as Spain nears the one-year mark until its elections, with the November 9 referendum now in the rear-view mirror, the brinksmanship between Rajoy and Mas won't matter if they can't find a path toward reconciliation. At this time next year, their respective governments could be headed by much more radical figures.
artur masCameroncastiliancatalunyaCDCCiUconvergenceERCesquerrafrancogeneralitatindependence referendumindignadosjordi pujoljunquerasMASpablo iglesiaspedro sanchezpeople's partypodemosPPPSOEpujolrajoyrepublican left of catalunyascotlandspainspanish socialist workers' partyunioZapatero
Catalunya, Spain
Mas cancels official Catalan independence vote
Photo credit to Diario de Navarra.
If you thought that the Scottish independence referendum was a divisive matter, just wait another three weeks.
Even though Catalunya's regional president Artur Mas officially cancelled a scheduled referendum on Catalan independence originally scheduled for November 9, diffusing a constitutional crisis with the national Spanish government, Mas announced that Catalans will instead have the option to participate in a non-binding 'consultation.'
From referendum to 'consultation'
In substance, the informal 'consultation' isn't incredibly different than the formal vote that Mas (pictured above) and the Catalan regional parliament initially scheduled, given that Spanish prime minister Mariano Rajoy denounced the vote and questioned the ability of Mas or a majority of the Catalan parliament to call a referendum legally. Spain's constitutional court ruled the referendum unconstitutional at the end of September, and Mas originally declared that the vote would go forward.
RELATED: Can Felipe VI do for federalism what
Juan Carlos did for democracy?
Mas's admission this week that the vote will be informal and non-binding reduces many of the tensions with Madrid, though the original vote wasn't entirely binding, either. But his announcement may dampen his credibility with pro-independence Catalans (critics took to Twitter to declare it was 'game over' for Mas) and force the third regional election in four years.
Nevertheless, the referendum will still ask Catalan voters the same two questions as before:
Do you want Catalonia to be a state?
If so, do you want Catalonia to be an independent state?
No matter what happened on November 9, no one believed that the issue of Catalan sovereignty would be definitively settled anytime soon. Continue reading Mas cancels official Catalan independence vote →
artur masC'scataloniacatalunyaCiUconvergence and unionERCfederalismICVindependence referendumjunqueraspedro sanchezpeople's partypodemosPPPSCPSOErajoyreferendumrepublican left of catalunyaspainspanish socialist workers' party
New PSOE leader Sánchez faces uphill struggle to unite Spanish left
July 24, 2014 Kevin Lees	Leave a comment
He's a disarmingly handsome economics professor, and he's the first major Spanish party leader who grew up chiefly in the post-Franco era and in the era of Spanish democracy.
But Pedro Sánchez, who leapfrogged the more well-known Eduardo Madina to become the leader of Spain's Partido Socialista Obrero Español (PSOE, Spanish Socialist Workers' Party) earlier this month, and who will assume the leadership later this week, will have his work cut out for him before elections that will take place within the next 17 months, with the party's traditional voting base increasingly supporting both new and established alternatives on the Spanish left.
Sánchez (pictured above), just 42 years old, has only been a member of the Congreso de los Diputados (Congress of Deputies), the lower house of the Spanish parliament, the Cortes Generales, from 2009 to 2011 and since January 2013, representing Madrid, where he served as a city councillor for the preceding five years.
Sánchez won the PSOE's first direct contest to elect the party's general secretary in a three-way race, with 48.7% of all votes against just 36.1% for Madina and 15.1% for the more left-wing José Antonio Pérez Tapias.
Though Madina, at age 38, is even younger than Sánchez, he's been a member of the Congress of Deputies since 2004 and the secretary-general of the PSOE's congressional caucus since 2009. A Basque federalist, he was perceived as the frontrunner in the race, especially after taking a republican stand in the aftermath of Juan Carlos I's abdication from the throne. But the favorite to lead the PSOE, Andalusia's 39-year-old regional president, Susana Díaz, endorsed Sánchez instead, as did many former officials from the administration of former prime minister José Luis Rodríguez Zapatero, including former public works and transportation minister José Blanco.
That effectively lifted the more unknown Sánchez, who holds a doctorate in economics, above Madina, who once lost part of his left leg in a Basque nationalist bomb blast.
On his election, Sánchez declared the 'beginning of the end of Rajoy,' challenging the unpopular center-right government of prime minister Mariano Rajoy, which has presided over the worst of Spain's recent economic crisis.
Not so fast. Continue reading New PSOE leader Sánchez faces uphill struggle to unite Spanish left →
artur masbasque countrycatalunyachaconCiUconvergence and unioneduardo madinaERCeuskadiezker abertzaleaindignadoizquierda unidapablo iglesiaspatxi lopezpeople's partypodemosPPPSOErajoyrepublican left of catalunyarepublicanismrubalcabaspainspanish socialist workers' partysusana diazunited leftZapatero
With Spanish left reeling, Rubalcaba steps down as PSOE leader
May 26, 2014 Kevin Lees	Leave a comment
The European parliamentary elections have claimed their first national leader in Alfredo Pérez Rubalcaba, the general secretary of the Partido Socialista Obrero Español (PSOE, Spanish Socialist Workers' Party), Spain's traditional center-left party.
In Sunday's elections, Spanish voters elected 54 members of the European Parliament. The ruling Partido Popular (the PP, or the People's Party) of prime minister Mariano Rajoy won the largest share of the vote, around 26%, and the largest number of seats, 16.
The PSOE placed second with just 23% and 14 seats — that's a loss of nine seats in the European Parliament.
Rubalcaba, taking the blame for his party's losses, announced he would step down from the leadership, calling a meeting on July 19-20 to select a new general secretary of Spain's largest center-left party:
"We have not managed to regain the trust of the citizens," Mr Rubalcaba told a press conference in Madrid on Monday, adding that he would not stand for re-election at an extraordinary party conference in July. "We have to take political responsibility for the bad results, and this decision is absolutely mine," he added.
There's no guarantee that the next PSOE leader will be able to unite the Spanish left, which has fractured in the face of the economic crisis in the past five years.
The PSOE's performance was hardly much worse than Rajoy's party, which lost eight seats. Taken together, the two major Spanish parties won around 49% of the vote. That's down from nearly 84% in the 2008 Spanish general election, 80% in the previous 2009 European elections and 73% in the 2011 general election.
So while the greater pressure fell on Rubalcaba and the PSOE, the results are hardly heartening for Rajoy. Continue reading With Spanish left reeling, Rubalcaba steps down as PSOE leader →
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Basque Country, Catalunya, Galicia, Spain
Rajoy survives election season in Spain's most separatist regions
November 28, 2012 Kevin Lees	1 Comment
It's not exactly accurate to say that Spanish prime minister Mariano Rajoy has 'won' in the aftermath of three regional elections in the past two months in Galicia, Euskadi (i.e., the Basque Country) and Catalunya.
But it's fair to say that, compared to the worst-case result in each region, Rajoy's government is likely relieved at the results of each of the three elections, especially last weekend's Catalan elections, which threatened not only to undermine Rajoy's federal authority, but to undermine the stability of Spain as a nation-state.
Rajoy (pictured above, right, with Catalan president Artur Mas) has had an incredibly difficult first year since taking office in December 2011 — he's continued Spanish austerity policies in the face of continued recession and amid the highest unemployment within the eurozone (over 25%). With Spanish voters disillusioned about the economy and with Catalan voters, in particular, agitating for greater autonomy — if not full independence from Spain's federal union — Rajoy and his center-right Partido Popular (the PP, or the People's Party), together with the PP's various local, regional iterations, were playing defense, at best, in each region.
In each election, however, there are reasons for Rajoy to take heart.
It's obvious that the autumn's regional elections could have been much worse: Rajoy's party could have lost power in Galicia, the former radical leftist ETA sympathizers could have won control of the Basque government, and an outright majority win by Mas and the CiU in Catalunya would have likely caused an immediate political and, indeed, constitutional crisis — and, given the bond market's jitters, likely a financial crisis as well.
Continue reading Rajoy survives election season in Spain's most separatist regions →
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Athletes, Celebrities and Famous People With ADHD
For parents concerned about a learning disability causing difficulty for their children in school, it helps to know that many celebrities and famous people with ADHD faced the same challenges when they were younger and successfully overcame a similar struggle.
When a diagnosis of attention-deficit hyperactivity disorder is brought up, most people associate the condition with children, and for understandable reasons.
The average age of ADHD onset, according to the National Institute of Mental Health, is about 6 years old and it's one of the most common childhood mental health disorders today.
That said, it's not uncommon for people with ADHD to grow up without ever receiving a diagnosis, only to discover later in life that the disorder has been a root cause for some of their adversity.
In fact, it's common enough that many athletes, celebrities, and other famous people with ADHD have been open about their struggles.
The disorder can come with symptoms that make it a challenge to stay focused or pay attention. It can cause problems regulating behavior and controlling mood. It may also sometimes lead to bouts of near-manic energy.
Research suggests that an estimated 14 million adults, around 4.4 percent of the population, deal with the symptoms of ADHD on a daily basis.
Adults and young people with the condition are sometimes likely to self-medicate their symptoms with drugs and alcohol. Unfortunately, those with untreated or undiagnosed ADHD often develop substance use disorders alongside the condition.
The combination of substance addiction and ADHD is referred to as a co-occurring disorder or a dual diagnosis. Both issues must be treated at the same time for people to make a full recovery from one or the other.
However, the mere fact that high profile celebs and famous people with ADHD have been able to cope with the disorder and still lead productive and fulfilling lives should be a source of inspiration for anyone seeking treatment for attention-deficit hyperactivity disorder.
Here are 9 Celebrities and Famous People With ADHD
The recent divorce announcement of Bill Gates from his longtime wife, Melinda French Gates, has certainly made news, especially as it concerns the couple's estimated net worth of $126 billion and the effect it will have on the philanthropic Bill and Melinda Gates Foundation.
Whatever the reasons for the rift, Gates has admitted in the past that he's struggled with symptoms of ADHD and still has trouble learning new things. Most people wouldn't know it though, as he is an early computer pioneer and one of the richest men in the world.
2. Simone Biles
Simone Biles is the most decorated gymnast in history and is in the news right now for being the first woman to ever perform the Yurchenko double pike, an extremely dangerous maneuver that most gymnasts won't even train for.
She's so good at what she does, a controversy about judges punishing Biles for her incredible feats is now emerging.
The record-breaking gymnast told ESPN that she has ADHD and has taken medication for it since she was a child, adding that she's not ashamed of it nor is she embarrassed to let anyone know.
3. Michael Phelps
While we're talking about athletes, U.S. swimmer Michael Phelps, who is the most decorated Olympian ever, has had very public struggles with ADHD and substance abuse. In 2014, Phelps was arrested for DUI and attended rehab after the incident.
Two years later, in an interview with USA Today, the swimmer said, "I sent myself down a downward spiral. I think it was more of a sign than anything else that I had to get something under control."
4. Terry Bradshaw
Sticking with the theme of athletes for just a moment, Terry Bradshaw is a four-time Super Bowl champion turned professional sports commentator. The Pittsburgh Steeler quarterback admitted in his autobiography that not only has he struggled with ADHD, but has also battled a mood disorder.
Bradshaw was inducted into the hall of fame in 1989, despite his diagnoses.
5. Solange Knowles
Sister to Beyonce, a member of Destiny's Child and fierce, over-achieving musical artist all on her own, Solange Knowles says she was diagnosed with ADHD twice, but didn't believe it the first time.
The musician has since become an advocate for people that struggle with the condition, especially because of the low rate of diagnosis in Black children and the problematic symptoms being misunderstood and leading to a school-to-prison pipeline.
6. Will.i.am
Music, according to seven-time Grammy Award winner, Will.i.am, is one way in which he's actually channeled the symptoms of his ADHD.
The legendary producer and recording artist has said that creating music helps him stay focused and bring control to his thoughts.
7. Adam Levine
Maroon 5 front-man and a vocal coach on the hit TV show The Voice for 16 seasons, Adam Levine was diagnosed with ADHD as a child, but it wasn't until adulthood that the singer said his symptoms became unbearable and, at times, incapacitating.
When recording music grew nearly impossible for Levine, the singer knew it was time to get help. He has since been very open and vocal about supporting people with ADHD and encouraging them to get the help they need.
8. Paris Hilton
Whether being infamous or a famous person with ADHD, it doesn't really matter. Attention-deficit hyperactivity disorder can affect anyone, even the socialite and hotel heiress Paris Hilton.
In a previous interview with Larry King, Hilton said she was diagnosed with the disorder as a child and continues to take medication for it to this day.
9. Justin Timberlake
Being in the spotlight for so long can make anyone a bit reticent to talk openly about their struggles, for fear of criticism or simply wanting some aspects of their life to remain private.
After all, Justin Timberlake got his start with the "Mickey Mouse Club" as a child, went on to the mega-boy band N'SYNC, and then transitioned into an amazing solo artist. He even does movies from time to time.
In a 2008 interview with Collider, Timberlake admitted to suffering with both ADHD and obsessive-compulsive disorder (OCD). "You try living with that," Timberlake quipped.
Other Celebrities and Famous People With ADHD
The list of famous people with ADHD is not limited to those mentioned above. They may be some of the most vocal about living with the disorder, but there are many others who have found success.
Athletes, actors, musicians, and even astronauts have realized great accomplishments despite living with attention-deficit hyperactivity disorder. Here are other successful people with ADHD.
Britney Spears – Musician
Channing Tatum – Actor
Howie Mandel – Comedian and TV Host
Ty Pennington – TV Host
James Carville – Political Media Personality
Emma Watson – Actor
Carrie Underwood – Musician
Liv Tyler – Actor
Shaquille O'Neal – Athlete
Zooey Deschanel – Actor and Musician
Ryan Gosling – Actor
Glenn Beck – TV and Radio Personality
Russell Brand – Actor and Comedian
Jamie Oliver – Celebrity Chef
Pete Rose – Athlete
Katherine Ellison – Author
Scott Kelly – Astronaut
This is an impressive list of well-known people with ADHD who have proven it is possible to thrive in life despite the challenges of a mental health disorder.
They should serve as an inspiration for others who have been diagnosed with ADHD and fear it may hold them back in life.
Simone Biles by Agencia Brasil Fotografias
Michael Phelps by Agencia Brasil Fotografias
Solange Knowles by magicube77 (shay)
Adam Levine bygashleygoh
Paris Hilton by Gil Zetbase
Justin Timberlake by Gage Skidmore
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This cat is predicting a storm.
The climate's been so inconsistent lately—random winter storms, polar vortexes—maybe you should stop listening to science for weather reports and go back to the only source you can really trust: your cat.
That's the suggestion of H.H.C. Dunwoody, an Army first lieutenant who suggested in 1883 that rather than putting our faith in meteorologists who can't predict the weather "for a longer period than two or three days, and frequently not longer than twenty-four hours," we should follow the wisdom of animals.
In his book Weather Proverbs, unearthed by NPR, Dunwoody documents a long list of widely-held folk beliefs about weather predictions, including signals from bears, foxes, and goats, but he particularly focuses on cats. Here's what you should look for.
When cats sneeze it is a sign of rain.
The cardinal point to which a cat turns and washes her face after rain shows the directing from which the wind will blow.
When cats are snoring foul weather follows.
It is a sign of rain if the cat washes her head behind her ear.
When cats lie on their head with mouth turned up [on their back] expect a storm.
When a cat washes her face with her back to the fire expect a thaw in winter.
Apparently too many cats have been snoring, and not enough are washing their faces while turned away from the fire. Cat owners, get to it, and we just might survive this winter yet.


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redpajama_set_name: RedPajamaGithub


Truckies will love these! They're the hard workers who drive the big rigs that keep Australia moving, because without our truckie heroes, Australia stops! Now you can show your pride with these new Truck prints, boasting of bright colour, shiny bullbars and amazing Australian scenes - perfect for an awesome Truck Quilt or wall hanging.
Out of all the Truck fabrics Kennard & Kennard have released, this Big Rigs 8024 collection has to be one of the best. For those that want all the added extras, these fabric panels show all the special bling in detail on these fantastic trucks.
Designed exclusively for Kennard & Kennard, Big Rigs will be loved especially by anyone who loves trucks. We know you will be blown away by the vibrance and clarity of these designs.


text:
Q: Retrieveing the Query that Created a Doctrine_Collection I have a Doctrine_Collection object that was created with code that looks something like.
$collection = Doctrine_Query::create()
->from('FooBazBar')
->where('widget_id = ?',$some_var)
->execute();

Short of writing it down somewhere, is it possible to to retrieve the where clause that was used to create the collection?
That is, I want to be able to so something like
$collection->getWhereClauses(); //fake method

And get back the where clause in some form.
A definitive "no, this isn't exposed via the API" with an explanation is a perfectly reasonable answer here.

A: No, this isn't exposed via the API.
More seriously, you can't retrieve the query that generated the Doctrine_Collection. The easy way to do this is to create a method in your table, like :
//FooTable.php
public function findByWidgetQuery()
{
return $this->createQuery('foo')
  ->where('foo.baz = ?', 'bar');
}

And then you can use getDqlPart() like this :
$where = Doctrine_Core::getTable('Foo')
->findByWidgetQuery()
->getDqlPart('where');

That should give you an array like this one :
array(2) { [0] => string(8) 'widget = ?' [1] => string(10) 'widget = ?' }

Note that it doesn't return the actual value passed to the where() clause. To do this you need to use Doctrine_Query::getParams() or Doctrine_Query::getFlattenedParams()
You can find everything in the Doctrine API.

A: getSqlQuery() looks to be the method you're after...
http://www.doctrine-project.org/documentation/manual/1_0/en/dql-doctrine-query-language:debugging-queries

redpajama_set_name: RedPajamaStackExchange


It's been almost 18 months since the highly criticized HR 347 (also known officially as the "Federal Restricted Buildings and Grounds Improvement Act of 2011" was signed into law. What this bill did, was essentially criminalize protesting the president. Infamously in certain circles, the bill was one of the only things Congress could bring itself to agree on last year, passing overwhelmingly 399-3, with 30 votes abstaining. Only Paul Broun (R, Georgia), Justin Amash (R, Michigan), and Ron Paul voted against the bill in Congress.
The general purpose of the law is to create what amounts to a mobile federal protection zone around anyone under Secret Service protection (most notably the President himself). This puts people under federal jurisdiction and leaves them open to federal prosecution should the "enter or remain" in such a restricted area. This also applies to anyone within that zone who takes part in "disorderly or disruptive conduct" with the intent and effect of impeding or disrupting government business or official functions, or blocking entrance to or exit from a restricted area.
What many people don't understand about this "new" law, is that it's not actually new. Most of it has been in place since a massive overhaul of the bill in 2006. Prior to that some form of this bill has existed since the early 70's. The difference in THIS "improvement" of the bill, is that a person no longer has to be in this area knowingly. Prior to this "improvement" persons would have to carry out these acts both "willfully" and "knowingly". Following this "improvement" a person only has to be knowingly in the zone, they do not have to be "willful" which legally means that they knew their behavior was illegal. In short, this lowers the bar federal prosecutors have to clear to prosecute protesters of events such as G-20 summits, or the RNC or DNC.
1) That's a popular refrain these days. And with good reason, since the signing of the Patriot Act, there has been a steady assault on liberty and freedom from DC. In recent days you've heard about the NSA, but before that we had CISPA and before that NSL's. The NSA spying is hardly either the worst OR first of it. For at least the past four years, the government has been issuing demands to companies like Google for information using "NSLs" (or "National Security Letters") hand in hand with gag orders so you don't even know if your information has been subpoenaed. Just a few months ago, Google issued a report pictured below which attempted to quantify how many of these NSLs it had received over that time period. Like I said. This is not a new thing.
With that said, it's always been an assault on those things, this just gave it wheels and a lower bar of standards for the prosecutors. In other words it did what every "improvement" of a bill has always done: expanded the powers of that bill.
The public reacted as the American public has always reacted when told not to do something: they tested it. And not just a few nobodies either. A presidential candidate was arrested-but not charged. She was the Green Party candidate Jill Stein, but a candidate nonetheless, who was detained for protesting the debates for not being more inclusive. Actor Georce Clooney was also arrested protesting outside an embassy shortly after the law was signed.
In the end, the government did what it always does in these situations. It let the ACLU have their say, let the public outcry in the form of blogs and protests, and eventually everyone moved on. They moved on to the next issue, or baseball season, or graduate school, or whatever, but they forgot what outraged them so. Eventually whatever it is that was being protested, just becomes part of "the way things are" and by and large the people accept it, dissenters become outcasts and are ridiculed as extremists.
This is why I write this today; almost 18 months after this bill passed. 16 months after Clooney's arrest, and probably at least a year after any major news network even mentioned HR 347. Because I think that it's important that we do not forget. That we don't allow ourselves to become distracted by created and preceived battles between Democrats and Republicans, between red and blue, between black and white. It's times like this when the country has become more divided than I've seen it since the OJ trial at least that we need to remember that a year ago, this bill passed 399-3. Because at the end of the day, it's not about R or D in DC either. It's about them and us. Almost 18 months ago 399 representatives stood against us. Most of them have done it countless times before and since.
We cannot let their actions fade away and be forgotten, we need to constantly remind ourselves who we're really fighting for: the American people. Red or blue, black or white, we're ALL Americans, and there are some issues on which we ALL need to stand together: just as "our" legislators stood against us last February, and have done so many other times as well.
Kings Dead Review : "Revenge Of The Beast" Album, Solid And Ambitious.


Wellness and Fitness are two very important things for me. The two go hand in hand for me, for example, when I run I naturally eat better. When I train for a race, I feel better. I am grounded, confident, and able to bounce back from daily stresses, for me this is wellness.
Wellness for me are the things I do other than train that allow me to be a better version of myself.
This year I made a big goal to train and complete an Ultra Beast so naturally I need things in my life that nurture and help me succeed when it comes to this goal. For example, my nutrition needs to be food that gives me energy, makes me feel good, and bounce back from a tough workout.
When training for a big race or setting a huge goal the people in your life need to understand and support your goals. I say this because friends, family, and the people you spend your time with are an important part of your success. Their energy and habits directly affect yours. As you get older friendships and relationships change. I have found the strongest friendships and relationships endure. My "community" is filled with people who encourage, motivate and inspire, but I have had to make tough choices because it was not always this way.
Nutrition and Cooking I am always on the hunt for new and healthy recipes. I am not someone who diets. I eat everything in moderation and when I crave something I eat it. After long runs I always want some type of beef but would not define myself as a meat eater.
Reading: Continually learning and educating myself has helped in training. I try to read something every day even just for 20 to 30 minutes.
Internet: I'm trying to be more intentional with my actions, thoughts, and words. The things I read and look at on and off the internet directly shape who I am. You are what you do, read, and say, when no one is watching.
Running I have a big race schedule for 2017 (I will share this later) and a marathon coming up in April. The marathon is a "training run" for the Ultra Beast. I grew up running, but never really started running seriously until the past two years.
Cross Training and Weight Lifting: I am so grateful to have the best training partner :) he's continually creating circuit and weight lifting workouts that can be scaled down or up depending on the exercises we are doing that day.
Hiking: my favorite way to be active and explore.
I've come to the realization that to have big goals the work that you do, the things you say and repeat all affect the outcome. So, as my favorite training partner says," stop talking and start training" haha.
Stay tuned for more fitness and wellness tips as I train for the Ultra Beast.
Coeur de La copyright © 2009 - present. Simple theme. Powered by Blogger.


This section has materials to help you understand light and sound.
This first video shows how an oscilloscope works. It clearly shows how the amplitude or height from middle (zero disturbance) of a wave is the loudness. The frequency of a wave is the length show for a whole cycle (or circle/ up & down).


text:
Shaftesbury launches latest digital initiative "Carnaby Cares"
Tom Bottomley
London landlord Shaftesbury has just announced a new digital campaign called 'Carnaby Cares' to support initiatives for the NHS and other causes during the coronavirus pandemic.
The campaign aims to promote the wide range of projects going on across the Carnaby portfolio, with initiatives from Carnaby tenants including Barbour, BA&SH, MOSCOT, RRL, Aesop and M.A.C.
Shaftesbury director, Simon Quayle, said: "Since lockdown commenced, many of our retail and restaurant tenants in Carnaby were amongst the first to launch various initiatives to support the NHS, key workers and the most vulnerable. The inspirational content shows how businesses have adapted to help others, and shines a light on the positive community spirit."
French contemporary fashion brand BA&SH has designed and launched a hope-inspired T-shirt – with the slogan 'I Will Hug You Later' on the front – with 100% of profits going to NHS Charities.
Iconic US eyewear brand MOSCOT has pledged over $1.5 million worth of eyeglasses to emergency media professionals. Vintage Ralph Lauren store RRL has donated $10 Million to help the World Health Organisation (WHO) caring for people with cancer who are especially vulnerable at this time.
Luxury skincare brand Aesop has donated a number of its products to UK hospitals as well as launching a mindfulness playlist. Make-up experts MAC are donating $10,000,000 to over 250 local organisations across the world. The recognisable MAC 'Viva Glam' campaign, which traditionally donates 100% of sales of the Viva Glam Lipstick to at-risk communities, will now also support those at higher risk during the pandemic.
As has already been well reported, British heritage brand Barbour has turned its factories in South Shields into a production line for PPE, delivering gowns to hospitals in the North East of England.
Additionally, 10% of April sales from customers purchasing from Diesel online went towards the OTB Foundation, to help combat the coronavirus with sufficient medical equipment. And those working for the emergency services can receive 20% discount at size? and 30% discount at Superga.
The campaign will run across Carnaby's social media channels and website and a full list of all the various initiatives can now be found at: Carnaby.co.uk/CarnabyCares/
Simon Quayle
shaftsbury
Carnaby Cares


text:
Research > Technology Transfer
Nutraceuticals and Nanoparticles
October 30, 2008 Contact Author	Johann Wiechers, PhD
"COSMETICS LAB" - The new cosmetics magazine made for scientists by scientists. — Buchi
Epi-On™– Holistic skin recovery through epigenetic pathway – efficacy study — Corum Incorporation
Most Popular in Technology Transfer
1Personalized Cosmetics: Has the Time Come?*
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3Measles, Mumps and Acne?
4Theobromine for Tooth Decay Prevention
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6Cosmogizmoceuticals: The Physics and Chemistry of Looking Better
7PFC for Oxygen Delivery to Skin
8What Food Science Can Lend to Skin Care
9Kombucha Transfers from Tea to Skin for a Brightening Effect
10Lipidomics Researcher Maps Lipid Transfer Between Cells
Editor's note: Johann W. Wiechers, PhD, of JW Solutions, opens his new series of monthly C&T Today e-newsletter features with this fresh look at nutraceuticals and nanoparticles. Check out the August issue of C&T magazine for more on these hot topics of interest.
Nutraceuticals and Nanoparticles... Not the most logical combination of topics for my very first e-newsletter column, but life is full of surprises. Its abbreviation, N.N., stands for anonymous (at least in The Netherlands), and that actually is a thing that unites these two subjects; public awareness, also known as perception, and what the reality is or could be. Let me explain.
Nutraceuticals is a new category of products that feed and nourish the skin from the inside out. Not a cosmetic that you apply to the area that needs it most, but a cosmetic that you eat. When I asked my wife today what a nutraceutical was, she could not tell me. Nutraceuticals are anonymous. When I explained to her what it was, she was not totally convinced about the world's latest need for nutraceuticals. I did explain to her that our skin needs specific building blocks like linoleic acid and linolenic acid, which our bodies cannot produce and that they are therefore called essential. "But why not apply them in a cream? Why eat them?" is what she asked. That really got me thinking. Why eat and not apply them topically?
Of course, there is a beautiful link with essential nutrients in food. Eat your skin healthy! But I also remember having performed skin penetration experiments in which you would only get roughly 1% of a dosed amount into the skin. Would eating be better? To answer my wife's question, I had to do some calculations. Normally, cosmetics are applied at a rate of 1 mg/cm2. Typical levels of linoleic acid in a cream would be maximally 1%, which corresponds to 1 g/100 g cream, or 10 mg/g cream.
As only 1% penetrates, this corresponds to 0.1 mg or 100 µg penetrating into the skin per square centimeter from a single dose. Is this better than eating the essential nutrient? A typical product form for nutraceuticals, if I may believe advertisements on Dutch television, is yoghurt that is sold in small pots. According to certain advertisements, every great-looking woman is bound to suffer from constipation that will make her feel (and, God forbid, look) like a balloon. Despite her shining beauty, she has a tough life--but help is nearby. She eats a pot of yoghurt every day containing a strain of beneficial bacteria and 14 days later, she will feel flat and beautiful again. Finally, she can even have a rest in the restroom.
But let's assume for a moment that we already have a yoghurt on the market containing the skin-essential molecules linoleic and/or linolenic acid. As the daily volumes of yoghurt consumed are bigger than that of a cosmetic cream, its dose has been reduced to 0.1%, but with a 125-ml pot, still 125 mg enters her body if we assume a specific density of 1 g/ml.
Uptake of essential elements from food is much higher than that percutaneously absorbed; I assume 50%, but it could be much higher. That would mean that 62.5 mg of linoleic acid penetrates into the bloodstream. If only 10% of that goes to the skin and the typical adult body is 1.8 m2 in surface area, this would equate to a level of 6.25 mg/18,000 cm2, which is 0.347 µg/cm2--substantially lower than the 100 µg/cm2 we found in the skin following topical application. But of course, I had to make quite a few assumptions. Even in the best-case scenario (100% uptake into the body, and 100% ends up in the skin), the answer is still only 12.5 µg/cm2--still eight-fold less than delivered via the topical route from a nonoptimized formulation.
Of course, you could increase the level of linoleic acid to 1% in the yoghurt in an attempt to beat the cream, but I think this example shows that if you apply your chemical to where it is needed most, you have a higher probability of success and that targeted application works to your benefit.
Topically applying a formulation is a form of targeted delivery. And nanoparticles are all about delivery, aren't they? They have become a bit of a hype and every marketer wants to be able to claim the four letters N-a-n-o somewhere on the bottle--and for good reasons, by the way, because these little things have really shown that size does matter. They are small but their actions are large, if not immense. They seem to be able to do everything.
But unlike nutraceuticals, nanoparticles are not completely unknown to the public at large. Media have indicated that they are dangerous and should be handled with care. They have shown to penetrate skin--of course, otherwise they would not work--but the risks are actually minimal. A solid penetrates at a rate 10,000-fold slower than a dissolved molecule. So, what is the risk?
Prof. Dr. Jürgen Lademann (Charité University, Berlin, Germany) spoke at the "Trailblazing the Skin Frontier" Workshop, held at George Washington University in Washington, DC, USA, from Aug. 11-13, 2007. He and his colleagues showed that 5-µm diameter nanoparticles penetrate preferentially into the infundibulum, the small gap between the hair shaft and the inwardly curving skin. This means that titanium dioxide or zinc oxide of the same proportions should also, to some extent, penetrate the skin. But is this a reason for not using particulate sunscreens, as consumer watchdog programs want consumers to believe? Does this not remind you of a similar situation a few years ago when we were told not to use organic sun filters because of their estrogenic activity? As Prof. Lademann said, it is much, really much more dangerous not to use a sunscreen than to have these minute amounts of titanium dioxide or zinc oxide penetrating into the body.
Both topics, nutraceuticals and nanoparticles, have a great future ahead of them. In the case of nutraceuticals, long-term clinical studies will have to show their benefit and these studies will not be as easy as those examining topical cosmetics. Testing topical cosmetics tends to involve on one arm, applying the product with the cosmetic; on the other, applying a placebo or no product at all. Every subject acts as his or her own control. These so-called paired comparisons mean that fewer subjects are required to show a statistically significant difference.
But this will not be possible with nutraceuticals. If you eat the active ingredient, then it may or may not end up in the skin. If it does, it goes everywhere and treats the skin everywhere. Clinical trials demonstrating the benefit of nutraceuticals are therefore more complicated than most other cosmetic trials. And whereas any improvement on a site where a product has been applied topically is immediately assumed to be caused by this product--after all, it makes sense, doesn't it?--colleagues in the nutraceutical arena have all appearances against them, even if the skin appearance is excellent. How do you conclusively show that the observed skin improvement was caused by eating a product? For the moment being, I remain skeptical--not about the technical side, but about the capabilities to convince the consumer.
Nanoparticles, however, are a new subject area that offers great opportunities. They have great potential as a delivery device, a sensory clue, a reservoir for targeted and controlled and event-controlled delivery, to name a few.
In short, this may have been my first column on these issues for the C&T Today e-newsletter, but I am certain that there will plenty more to report in a year's time on both subjects. Just stay tuned!
Johann W. Wiechers, PhD
Technical Advisor, Allured Publishing
Independent Consultant for Cosmetic Science
JW Solutions, Gasthuispolderweg 30 2807 LL Gouda, The Netherlands
johann.wiechers@versatel.nl
Corbion Copolymer Enables Stimulus-activated Controlled Release for Novel Applications
Formulation Database to Accelerate Product Development
$util.date("M/d/yyyy", $riObj.liveDate), Michele Behrens
Don't Sweat It: Wearable Sensor Detects Wellness Indicators
1/22/2020, Michele Behrens


text:
cardactivationinfo.com
What Are The 4 Ways To Amend The Constitution?
How many ways can the Constitution be amended?
Can an amendment be removed?
What are the three ways to change the Constitution?
What are the two methods utilized to formally amend the Constitution?
Is there a way to change the Constitution?
Why is it so hard to amend the Constitution?
Can the president change the Constitution?
When was the last amendment passed?
What are the 4 methods to amend the Constitution?
What are the 4 ways the Constitution can be amended quizlet?
What is the most common way to formally amend the Constitution?
Who can change the Constitution?
There are actually four ways.
(1) Both houses propose an amendment with a two-thirds vote, and three-fourths of the state legislatures approve.
Twenty-six of the 27 amendments were approved in this manner..
It is unique among the 27 amendments of the U.S. Constitution for being the only one to repeal a prior amendment, as well as being the only amendment to have been ratified by state ratifying conventions.
There are actually four different ways, but only one is widely used:Proposal by convention of the states, with ratification by state conventions. … Proposal by convention of the states, with ratification by state legislatures. … Proposal by Congress, with ratification by state conventions.More items…
Article V creates a two-stage process for amending the Constitution: proposal and ratification. An amendment can be proposed by two-thirds of both houses of Congress or… By two-thirds of state legislatures requesting Congress to call a national convention to propose amendments.
Under Article V of the Constitution, there are two ways to propose and ratify amendments to the Constitution. To propose amendments, two-thirds of both houses of Congress can vote to propose an amendment, or two-thirds of the state legislatures can ask Congress to call a national convention to propose amendments.
Any proposal to amend the Constitution is idle because it's effectively impossible. The problem starts with Article 5 of the Constitution. … The founders made the amendment process difficult because they wanted to lock in the political deals that made ratification of the Constitution possible.
In his farewell address, President George Washington said: If in the opinion of the People the distribution or modification of the Constitutional powers be in any particular wrong, let it be corrected by an amendment in the way which the Constitution designates.
1992Twenty-seventh Amendment, amendment (1992) to the Constitution of the United States that required any change to the rate of compensation for members of the U.S. Congress to take effect only after the subsequent election in the House of Representatives.
The Constitution, then, spells out four paths for an amendment: Proposal by convention of states, ratification by state conventions (never used) Proposal by convention of states, ratification by state legislatures (never used) Proposal by Congress, ratification by state conventions (used once)
Terms in this set (4)Method 1. Proposed by 2/3 vote in both houses; Ratified by 3/4 of State Legislatures (Used 26 times)Method 2. Proposed by congress by 2/3 vote in both houses> Ratified by conventions held in 3/4 of states (Used once 21st one)Method 3. … Method 4.
a) The most common way to add an amendment to the Constitution would be to propose it by a 2/3 vote of each house of Congress and be ratified by 3/4 of the state legislatures.
The Constitution provides that an amendment may be proposed either by the Congress with a two-thirds majority vote in both the House of Representatives and the Senate or by a constitutional convention called for by two-thirds of the State legislatures.
Quick Answer: Can You Love Someone And Still Cheat?
Do cheaters always cheat again? The phrase '
Quick Answer: Is Blazen A Word?
What is a blazen? Verb. blazen. (intransitive, sometimes
Quick Answer: Why Do Guys Hearts Beat Fast When Cuddling?
Do guys like hugs? Most guys like hugs, but like girls
Question: Can You Plead The Fifth If Subpoenaed?
What does I plead the 6th mean? Posted on August 1
Quick Answer: What Is The Best Age To Tell A Child They Are Adopted?
Do you have to tell your child they are adopted?
Question: What States Still Have Death Row?
When was the last execution in the US? 2003The last
What Crimes Get The Death Penalty In US?
How common is the death penalty in the US?
Question: Why Did The Founding Fathers Make It Difficult For The Constitution To Be Amended?
Can the US Constitution be changed? The Constitution
Question: Why Is The Rule Of Law Is Important?
What is the rule of law easy definition? Rule of law
Quick Answer: Who Was Executed In 2020?
How heavy was the guillotine blade? The Halifax Gibbet
What Does Sizzling Mean?
What does sizzle mean in slang? OxycontinSIZZLE means "
Is Kissing Before Marriage Haram?
Is lip kissing Haram? At the same time, there is no
Quick Answer: What'S A Sket?
What does YEET mean in text? Yeet is an exclamation
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Beautifully refurbished 3 bedroom single level free standing brick villa, with quality carpets and a tasteful paint scheme throughout. Thinking of downsizing or investing then this villa may suit you.
Spacious open plan lounge/dining room with a new Mitsubishi air conditioner for your comfort.
Laminated kitchen with loads of cupboards, excellent bench space and a Westinghouse gas stove.
Tiled 3 way bathroom with a new solid white vanity and an exhaust fan.
All bedrooms have loads of built-ins and 2 have ceiling fans. The main bedroom has a 4 door wardrobe.
Internal access to the large single garage including an automatic roller door with shelving at the rear.
Relax in the private rear courtyard or enjoy a barbecue with friends.
Situated close to public transport and a short drive to Wallsend and Glendale Shopping Centres, parks and amenities.