I have always been very passionate about sport, and very competitive. I started racing BMX at the age of 3 in the under 5 boy's category. Although I competed in a large number of other sports at national level during my school years, my number one passion was BMX racing.
Not only did I compete in many sports, I trained for them. From the age of 5 to 15yrs I trained everyday of the week before and/or after school. In my younger years I was a gymnast at national level, and then I started little athletics and enjoyed the middle to longer distances. Outside of school, sports like touch football, softball etc… I was soon training for athletics, cross country running, swimming, surf lifesaving, tennis, netball and BMX.
At the age of 13 I decided to drop many sports to concentrate on Surf Lifesaving and BMX – I trained everyday of the week and was competing nationally and internationally.
It was at this point that I developed a burning desire to represent Australia and become a professional athlete and an Olympian. In order to do this I needed to decide on a sport and specialise. Neither Surf Lifesaving nor BMX were Olympic sports at the time.
I had been identified by a talent ID program for having potential talent as a cyclist and I was being tracked down by a local academy of sport cycling coach – Mitch Law. Within 3 weeks Mitch had coached me to a NSW championship and within 3 months I was the U15 National Champion.
As a junior cyclist I focused on the track (velodrome) and won a number of junior National Championships and a World Championship Silver medal. I went on to win senior/elite World Cups and two World Championship silver medals on the track, and also won two silver medals at the 2002 and 2006 Commonwealth Games before turning my focus to road cycling.
I am now a professional Road Cyclist. I have won a World Cup and claimed many World Cup podiums as a professional cyclist; my greatest achievements also include stage wins in the Giro d'Italia and Route De France. In cycling terms I am just entering my strongest years in this sport. At 28 years of age, I am chasing the ultimate goals of Commonwealth, World and Olympic gold medals!
I lived with my grandparents for a number of years and became very close to my late Grandma (I still stays with my Grandpa when I am in Australia). I moved out of home at the age of 15yrs and grew up very quickly finding my own way in life while remaining close to my family, especially my mother who is my biggest supporter and best friend.
Whilst my two older brothers and sister live in Sydney where I'm based every Australia summer I still manage to squeeze in a visit to Tweed Heads each year to see my natural father, stepmother and younger brother and sister. It's fair to say the large family remain close at heart!
In order to travel to Europe to compete as an elite cyclist at the age of 15 yrs, I left school and continued my studies by correspondence. I have studied Sports Journalism, Sports Science, Fitness and Advanced Resistance Training, Sports Massage, Business and the Italian Language. I now speak fluent Italian. I currently manage two cycling teams (Lotto Ladies Team and the Honda Dream Team), I own a cycling clothing label (rmgsport.com) and compete as a professional athlete.
In 2006 I settled into my Italian home in the Italian dolomites and spent a year renovating the interior to suit my style and comfort. I feel at home in my Northern Italian home – in the heart of the dolomites.
I really enjoy quiet time home alone in between racing tours. I live a very busy life on the road – literally, I would be lucky to get 30 days at home in one year! This has been my lifestyle for the past 10 years.
If I want to forget about cycling or business for a few hours I will look for an extreme sporting activity – I have recently found a passion for racing cars around a track, it became an addiction during this past Australian summer and is something I will try to fit into my schedule regularly this coming Australian summer.
I like to work on my own bike, or closely watch my mechanic work. I have all the tools I could possibly need to build a bike, set up a bike or to change bottom bracket and wheel bearings. I bet my personal tool box and spares box is more complete than most women's pro teams would have! I am passionate about working on my bikes and thoroughly enjoy it! I guess I get that from my brothers and step father who are seriously into motorsports – where their vehicles' performance is as equally as important as their physical performance.


The Garden Games Chess Set is an oversized version of the table top classic.
Suitable for both indoor and outdoor use, the large Chess Set is perfect for parties, BBQ's, weddings and days at the beach.
With a base diameter of 9.5cm and the king standing 32cm tall, this hands-on game will come to life and have the player feeling involved.
Weighted pieces offer stability when playing the Garden Chess outdoors in windy conditions. However if the weather takes a turn, they can be easily carried indoors to play on a table or floor.
Included in the set is a 1.2m PVC chess mat that can easily fold away to store. This large chess game will keep family members of all ages entertained for hours.
If you're looking for an even larger chess game, try our Garden Games Giant Chess Pieces.
Perfect for players of all ages and abilities, it's a great way to learn the rules of chess.


Marilynn Seits is available for jazz and other types of performances in the Asheville area with a duo (bass and piano) or trio (bass, drums, piano). Please call or text for more info and rates.
My Bosendorfer is tuned and the studio is about set up so I am now ready for new students. If you're interested in piano lessons, jazz improv, vocal coaching, recording a demo or rehearsing songs for an audition or performance, call me to set up a time.
~ Lessons: Marilynn teaches all levels, both jazz & classical piano, voice, general music, composition lessons.
~ M Seits Publishing: A BMI Publisher: - We have published over 120 songs for seven different composers.


Words? The modern press release needs no words—only GIFs.
Don't believe me? Check out the latest press release from ChildFund International (not to be confused with George Costanza's Human Fund). The nonprofit issued a GIF-only press release to support its annual Real Gifts catalog.
ChildFund International's goal is to bring useful items like goats, cows and chickens to families around the world that need them. There are more than 100 such items for purchase in the organization's Real Gifts catalog.
You can check out the full press release here and find a translation here.
The image-laden release follows in the footsteps of Chevy's all-emoji press release that the auto brand shared last summer.
What do you think of the tactic, Ragan readers? Is this a new direction for press releases, or just a novel stunt?


With the return of the Duithèn and the rebuilding of the kingdoms of Darkness, the men of Thaeìn were now facing the very end of their world. Their own strength had waned greatly since the end of the Second Age, and it appeared they would not last long against the storm that was now gathering against them.
What little hope remained was in that the Bridge of Aélûr remained broken, and so there was no connection yet between the kingdoms of Aélûr and Thaeìn. As such, it was impossible for the men of Aélûr and their terrible allies to reinforce the forces of Thaeìn; though together they might well crush the kingdoms of men swiftly, separate their strength was not yet great.
It was the hope of the Duithèn that the finding of Namrâth might change all this.
Read the complete section here.


The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a cAMP-regulated epithelial Cl? route that, when faulty, causes cystic fibrosis. 1997; Zhou et al., 2002) at high micromolar concentrations where it impacts additional Cl? and cation stations (Sturgess et al., 1988; Rabe et al., 1995; Schultz et al., 1999). Additional nonselective anion transportation inhibitors, including diphenylamine-2-carboxylate (DPC), BMS-536924 5-nitro-2(3-phenylpropyl-amino)benzoate (NPPB), and flufenamic acidity, also inhibit CFTR at high concentrations by occluding the pore at an intracellular site (Dawson et al., 1999; McCarty, 2000). Our lab created a high-throughput testing assay for finding of CFTR activators and inhibitors (Galietta et al., 2001). CFTR halide transportation function is usually quantified from enough time span of fluorescence in response for an iodide gradient in cells coexpressing a green fluorescent proteinCbased halide sensor (Jayaraman et al., 2000; Galietta et al., 2001) and wild-type CFTR or a CF-causing CFTR mutant. The assay was utilized to recognize small-molecule activators of crazy type and F508-CFTR with activating potencies right down to 100 nM (Ma et al., 2002b; Yang et al., 2003). A thiazolidinone course of CFTR inhibitors was recognized by screening of the assortment of 50,000 little, drug-like substances (Ma et al., 2002a). The business lead substance CFTRinh-172 inhibited CFTR Cl? conductance inside a voltage-independent way, most likely by binding towards the NBD1 domain name in the cytoplasmic surface area of CFTR (Ma et al., 2002a; Taddei et al., 2004). In undamaged cells, CFTR Cl? route function was 50% inhibited at CFTRinh-172 concentrations of 0.3C3 M based on cell type and membrane potential. CFTRinh-172 inhibited intestinal liquid secretion in response to cholera toxin and heat-stable (STa) toxin in rodents (Thiagarajah et al., 2004a), and led to the secretion of viscous, CF-like liquid from submucosal glands in pig and human being trachea (Thiagarajah et al., 2004b). Although thiazolidinones are possibly useful as antidiarrheals as well as for the creation of CF pet models, they possess limited drinking water solubility (20 M) and inhibit CFTR by binding to its cytoplasmic-facing surface area, needing cell penetration with consequent systemic absorption when given orally. The goal of this function was BMS-536924 to recognize CFTR inhibitors with high drinking water solubility that occlude the CFTR pore by binding to a niche site Timp1 at its exterior surface area. A minimal stringency, high-throughput display of 100,000 little substances was performed to recognize novel chemical substance scaffolds with CFTR inhibitory activity. We recognized several fresh classes of CFTR inhibitors, among which was extremely water soluble, clogged CFTR by occlusion from the CFTR pore close to its external surface area, and inhibited CFTR function in vivo in rodent versions. MATERIALS AND Strategies High-throughput Testing for Recognition of CFTR Inhibitors Testing was performed using a program (Beckman Coulter) comprising a 3-m robotic arm, CO2 incubator, dish washer, liquid managing function station, barcode audience, delidding station, dish sealer, and two fluorescence dish visitors (Optima; BMG Laboratory Systems), each built with two syringe pushes and HQ500/20X (500 10 nm) excitation and BMS-536924 HQ535/30M (535 15 nm) emission filter systems (Chroma Technology Corp.). 100,000 little substances (most 250C550 D) had been selected for testing from commercial resources (ChemBridge and ChemDiv) using algorithms made to increase chemical variety and drug-like properties. Substances were stored freezing as 2.5 mM share solutions in DMSO. Fisher rat thyroid (FRT) cells stably expressing wild-type human being CFTR and YFP-H148Q had been cultured on 96-well black-wall plates as explained previously (Ma et al., 2002b). For testing, cells in 96-well plates had been washed 3 x, and CFTR halide conductance was triggered by incubation for 15 min with an activating cocktail made up of 10 M forskolin, 20 M apigenin, and 100 M IBMX. Check substances (25 M last) had been added 5 min before assay of iodide influx where cells were subjected to a 100 mM inwardly aimed iodide gradient. YFP fluorescence was documented for 2 s before and 12 s after creation from the iodide gradient. Preliminary prices of iodide influx had been computed from enough time course of reducing fluorescence following the iodide gradient (Yang et.
Little molecules that bind with high affinity to thyroxine (T4) binding sites about transthyretin (TTR) kinetically stabilize the proteins tetrameric structure, thereby efficiently lowering the pace of tetramer dissociation in TTR related amyloidoses. 8 sulfate), 2,3,5-trichloro-4-sulfooxy-biphenyl (4-PCB 26 sulfate) and 2,3,4-trichloro-4-sulfooxy-biphenyl (4-PCB 33 sulfate)) found in this research had been supplied by the Synthesis Primary of the University or college of Iowa Superfund Study System and synthesized and characterized as explained elsewhere (Physique 2).31, 32 PCB sulfates were synthesized as the ammonium salts.32 Flufenamic acidity, 8-anilinonaphthalene-1-sulfonic acidity (ANS), and transthyretin purified from human being plasma ( 95%) had been all acquired from Sigma Aldrich (St. Louis, MO). The purity of TTR was regularly verified 71320-77-9 manufacture by SDS-PAGE. Open up in another window Physique 2 Chemical constructions of PCBs, OHPCBs and PCB sulfates employed in this research 2.2 Amyloid Inhibition Assay Assays had been conducted with small modifications of the previously described process.19 Briefly, aliquots (5 l) of PCB metabolites, ready as 720 M working solutions in either 33 percent33 % or 100 % (v/v) acetonitrile, had been coupled with 495 l of 7.2 M TTR (tetrameric focus) in phosphate buffer (25 mM sodium phosphate; 100 mM sodium chloride (NaCl); 1 mM EDTA; pH 7.5) in throw away cuvettes. Carrying out a 30 minute pre-incubation at 37C, 500 l acetate buffer (200 mM sodium acetate; 100 mM NaCl; 1 mM EDTA; pH 4.2) were added, thereby decreasing the pH of the perfect solution is to 4.4 and yielding equimolar concentrations of TTR and potential inhibitor (3.6 M). Pursuing 72 hours of incubation at 37C at night, the cuvettes had been vortexed and test turbidities had been determined by calculating their optical densities at 400 nm (OD400nm). TTR incubated in the current presence of 5 l acetonitrile (no inhibitor) offered as the unfavorable control as well as the decided OD400nm worth was normalized to 100 % fibril development. OD400nm values decided for examples incubated in the current presence of potential inhibitors had been examined as % Fosl1 fibril development in accordance with that decided for the unfavorable control. At least three individual determinations had been designed for each potential inhibitor. Correlations between amyloid inhibition and dissociation constants had been decided using Sigma Storyline 11.0 (Systat Software program Inc., San Jose, CA). 2.3 Molecular Docking Simulations Chemical substance structures (Determine 2) had been produced in ChemBioDraw Ultra 12.0 (Perkin Elmer, Waltham, MA) 71320-77-9 manufacture and imported right into a data source in the SYBYL X docking software program (Tripos, St.Louis, MO). Ligands had been after that energy-minimized using the Ligand Planning Device applying the Tripos pressure field with default guidelines. We ready the TTR receptor constructions (PDB no. 2F7I, 2G9K, 2G5U, 2GAbdominal) in the SYBYL X Framework Preparation Device by setting proteins chain termini to their billed says and adding hydrogen atoms (H-bonding orientation). Subsequently, staged energy minimizations using the default establishing had been completed applying the Powell technique (no initial marketing; Termination: Gradient 0.5 kcal/(mol*A); maximum iterations: 100) as well as the MMFF94s pressure field (Dielectric Function: Regular; Dielectric Regular: 1.0). The binding site (protomol) was described following the removal of co-crystallized ligands using 71320-77-9 manufacture the particular extracted ligand like a template (Threshold: 0.5; Bloat: 0.0). After the receptor constructions had been ready, energy-minimized PCB metabolites had been docked in to the binding site using the Geom algorithm in the SYBYL X Docking Suite as previously explained for 3-PCB 71320-77-9 manufacture 3 sulfate, 4-PCB 3 sulfate and 4-PCB 11 sulfate.30 Twenty different poses had been produced per compound and ranked relating with their binding energies. To be able to measure the binding simulations inside a constant manner, only the cheapest energy binding poses had been utilized for the interpretation from the outcomes. 2.4 ANS displacement assay Dedication of equilibrium dissociation constants for 4-PCB 8 sulfate was conducted as previously reported.30 Briefly, a remedy containing 0.5 M TTR and 5 M 71320-77-9 manufacture ANS was titrated with increasing concentrations of 4-PCB 8 sulfate as well as the reduction in fluorescence at 470 nm (ex. = 410 nm) was supervised. Fluorescence data in the focus range between 0 and 100 nM had been then put on a one site plus non-specific binding.
Lysenin is a pore-forming toxin from your coelomic liquid of earthworm leaves. research the system of illnesses using the acquired inhibitors also to develop fresh chemotherapeutic brokers acting in the 885060-08-2 supplier brand new system. Previously, we isolated protein-tyrosine kinase inhibitors, protein-tyrosine phosphatase inhibitors, anti-Ras substances, and NF-B inhibitors. These inhibitors all ameliorated disease versions in animals. Testing for inhibitors of Lysenin-induced hemolysis will be among the possible methods to better understand the system of Lysenins actions. Inhibitors of Lysenin-induced hemolysis could be useful as anti-inflammatory brokers. Furthermore, Lysenin should activate innate immunity by troubling the prospective membrane structure, particularly if it really is a sphingomyelin-binding proteins. Thus, Lysenin as well as the recently found inhibitors ought to be useful in learning the system of inflammatory illnesses, and also, inhibitors of Rabbit Polyclonal to MCL1 Lysenin-induced hemolysis could be useful as anti-inflammatory brokers. Therefore, we've aimed at testing inhibitors of Lysenin-induced hemolysis from herb components and microbial tradition filtrates. 2. Framework of Lysenin and Induction of Hemolysis Lysenin was cloned in 1997 for identifying the proteins that induces contraction of rat vascular easy muscle from your coelomic liquid of . The proteins was after that reported like a sphingomyelin-binding proteins . Injection from the coelomic liquid supernatant in to the vein of rats, mice and quails induces loss of life, as well as the energetic principle can be Lysenin . This earthworm is usually categorized inside a subclass of Oligochaeta in the phylum of Annelida . ejects its coelomic liquid when attacked or activated, as demonstrated in Physique 1. Lysenin is usually a pore-forming toxin existing in the coelomic liquid from the earthworm exhibited by circulation cytometry and immunocytochemistry that the best quantity of lysenin is usually indicated in the cell known as chloragocytes, which is usually one subgroup of earthworm immune system cells also known as coelomocyte . Lately, the framework of Lysenin was analyzed by crystallographic evaluation, and Colibus possess suggested it stocks a common ancestry with additional pore-forming protein from a varied group of eukaryotes and prokaryotes . Open up in another window Physique 1 Earthworm ejecting coelomic liquid. In the coelomic liquid, Lysenin includes a category of proteins as well as Lysenin-related proteins1 and Lysenin-related proteins2 . The series of proteins of Lysenin is usually more homologous compared to that of Lysenin-related proteins2 than that of Lysenin-related proteins1. Lysenin can induce hemolysis, as well as the Lysenin-induced hemolysis happens inside a temperature-dependent and dose-dependent way as evidenced by earlier research [10,18]. The quantity of sphingomyelin in the membrane also impacts hemolysis induction by Lysenin . Lysenin consists of six tryptophan residues and five of these are conserved in Lysenin-related proteins1 and Lysenin-related proteins2. Recent research show that conserved tryptophan could possibly be essential in the acknowledgement of sphingomyelin and hemolytic activity . The conversation of Lysenin to erythrocyte membranes made up of sphingomyelin happens in three phases, where the preliminary stage is connection of Lysenin to sphingomyelin of the prospective membrane; the next stage, the forming of oligomers that creates a rise in membrane permeability; and the 885060-08-2 supplier ultimate stage, the forming of the mature skin pores around the membrane inducing hemolysis (Physique 2). Pore development depends upon environment heat. Cell lysis happens easier at 37 C in comparison to that at 4 C. The membrane pore size created by Lysenin is usually approximated at around 3 nm . Open up in another window Physique 2 Pore development by Lysenin. Lately, many experts from various areas have attemptedto clarify the systems of hemolysis induced by Lysenin. A report by Ishitsuka and Kobayashi exhibited that cholesterol and sphingomyelin/Lysenin percentage affected oligomerization . Binding of 885060-08-2 supplier Lysenin to sphingomyelin was inhibited by the current presence of glycolipid, therefore hemolysis reduced . An electrophysiological analysis demonstrated that Lysenin substances created voltage-dependent ion-channels.
The secretase, well known as -site amyloid precursor protein cleaving enzyme 1 (BACE1), initiates the production from the toxic amyloid (A) that plays an essential early part in Alzheimers disease pathogenesis. Although expectations are high that BACE1 inhibitors may be efficacious for the avoidance or treatment of Alzheimers disease, worries have been elevated about potential mechanism-based side-effects of the medications. The potential of healing BACE1 inhibition might end up being a watershed in the treating Alzheimers disease. Launch Alzheimers disease is certainly characterised with the cerebral deposition of extracellular debris known as amyloid plaques that are comprised of amyloid peptides (A) of 38C43 aminoacids. Amyloid plaques are cardinal histopathological hallmarks of Alzheimers disease, fundamental towards the amyloid cascade hypothesis of the condition, which posits cerebral A deposition as an essential early participant in disease pathogenesis, eventually resulting in neurodegeneration and dementia.1 If the amyloid hypothesis is correct, then inhibition of cerebral A accumulation could benefit sufferers with Alzheimers disease. The secretase, known as -site amyloid precursor proteins (APP) cleaving enzyme 1 (BACE1), may be the enzyme that initiates A creation by cleaving the extracellular area of APP. Inhibitors of BACE1 are getting considered at the moment because of their potential to lessen cerebral A concentrations Rabbit Polyclonal to SEMA4A also to treat and stop Alzheimers disease. Although many guaranteeing BACE1 inhibitors are getting tested in individual clinical studies, many questions stay about the protection of these medications, the optimum degree of BACE1 inhibition to attain efficacy without undesirable side-effects, as well as the stage of disease of which to take care of for greatest healing gain. Right here, we review the potential of healing BACE1 inhibition for Alzheimers disease at an essential amount of time in the seek out effective methods to treatment and avoidance. Amyloid and Alzheimers disease In the mind, A is mostly made by neurons, although various other cell types, including astrocytes and various other glia, also generate A specifically under stress circumstances that creates glial activation, as takes place in Alzheimers disease. A is certainly formed with the sequential proteolysis of the sort 1 membrane proteins APP (body 1A). APP is certainly first cleaved with the -secretase enzyme to produce a membrane-bound C-terminal fragment known as C99.2 Another enzyme named secretase, made up of four transmembrane protein (presenilin, nicastrin, Pencil2, and Aph1), then slashes C99 to liberate A.3,4 Another protease, secretase, can cleave APP at a niche site within A, thus precluding its formation. Because both and secretases are necessary for creation of the, inhibition or modulation of the enzymes is known as a prime healing objective for reducing cerebral A concentrations in sufferers with Alzheimers disease. Conversely, activation of secretase may also enable healing A reduction. Open up in another window Body 1 Toremifene IC50 APP digesting and mutations impacting -secretase cleavage(A) APP is certainly a sort 1 membrane proteins that's sequentially cleaved by two aspartic proteases to create A. Initial, the -secretase enzyme slashes APP (1) to produce the N-terminus of the. Two APP fragments are created: membrane-bound C99 and secreted sAPP ectodomain (gray). Second, C99 is usually cleaved from Toremifene IC50 the -secretase enzyme (2) to create the C-terminus of the. A (crimson) is after that released in to the lumen from the endosome and secreted in to the extracellular moderate. An intracellular domain name, C59 (dark), can be created. (B) The aminoacids around the A domain name of APP are displayed as green circles. Aminoacids that impact Toremifene IC50 -secretase control of APP in human beings are demonstrated in yellowish circles, within that your wildtype residue is usually identified from the single-letter aminoacid code. The Lys670Asn/Met671Leu (Swedish) and Ala673Val mutations trigger FAD by raising the pace of -secretase cleavage and A creation, whereas the Ala673Thr mutation protects against Alzheimers disease by performing the contrary. All three mutations happen at or within one aminoacid from the -secretase cleavage site. Scissors display cleavage sites of the many secretases. APP=amyloid precursor proteins. A=amyloid peptides. sAPP=soluble peptide APP. Trend=familial Alzheimers disease. The genetics of human being disorders offer insights in to the pathogenic systems Toremifene IC50 of disease. For instance, the breakthrough of mutations in the LDL receptor elucidated the pathogenic function of high serum cholesterol concentrations in familial hypercholesterolaemia and coronary disease, ultimately resulting in the introduction of the broadly recommended statins that inhibit HMG-CoA reductase and reduce serum cholesterol for the treating Toremifene IC50 cardiovascular disease.5 Similarly, human genetics display that cerebral A accumulation is crucially mixed up in pathogenesis of.


text:
Het Campeonato Piauiense Segunda Divisão is het tweede niveau van het staatskampioenschap voetbal van de Braziliaanse deelstaat staat Piauí en wordt georganiseerd door de voetbalfederatie FFP. De competitie werd voor het eerst gespeeld in 1957 en werd met enkele onderbrekingen gespeeld tot 1967. De competitie keerde eenmalig terug in 1978 en hierna duurde het tot 2003 vooral er een nieuwe editie gespeeld werd. Van 2008 tot 2014 werd de competitie opnieuw afgevoerd en in 2015 en 2016 keerden ze nog terug voor twee seizoenen en opnieuw in 2019.

Overzicht
 1957 -  Piauí
 1958-1960 - Niet gespeeld
 1961 -  Rio Negro
 1962 - Niet gespeeld
 1963 -  Caiçara
 1964 -  Ferroviário
 1965 -  Botafogo
 1966 -  Auto Esporte
 1967 -  Fluminense
 1968-1977 - Niet gespeeld
 1978 -  Auto Esporte
 1979-2002 - Niet gespeeld
 2003 -  4 de Julho
 2004 -  Comercial
 2005 -  Barras
 2006 - Niet gespeeld
 2007 -  Picos
 2008-2014 - Niet gespeeld
 2015 -  Altos
 2016 -  4 de Julho
 2017-2018 - Niet gespeeld
 2019 -  Picos
 2020 -  Fluminense
 2021 -   Oeirense
 2022 -  Comercial

Campeonato Piauiense

redpajama_set_name: RedPajamaWikipedia


text:
Tanzanian President, Samia Hassan, appoints Emmanuel Tutuba as central bank governor
Ifeoluwa Dada
The President of Tanzania, Samia Suluhu Hassan has appointed Emmanuel Tutuba, to the position of central bank governor.
Tutuba until the appointment on Saturday was the Permanent Secretary at the Ministry of Finance and Planning.
According to the African Development Bank, the Tanzanian economy's GDP grew at 4.90% in 2021, up from 4.8% in 2020, supported by the global economic recovery. Growth was driven by agriculture and services on the supply side and final consumption and investment on the demand side.
But Tutuba inherits an economy facing inflationary pressure – inflation stood at 4.9% in November, roughly a five-year high. He replaces Florens Luoga, who reached the end of his five-year tenure.
The finance ministry in 2022 projected faster economic growth than in previous years with a plan to increase spending in 2023 with a focus on infrastructure projects.
Related Topics:Emmanuel TutubaFeaturedTanzania
Body of Tanzanian citizen killed in Ukraine while fighting for Russia, returns home
Tanzanian opposition leader, Tundu Lissu, back home after two years in exile
Weeks after lifted ban, Tanzanian opposition party, Chadema, holds first rally
Exiled Tanzanian opposition leader, Tundu Lissu, announces plan to return home
Oppositions applaud as Tanzanian President, Samia Suluhu, lifts ban on political rallies
The Kenyan statistics office has revealed that the country's inflation rate slowed to 9.0% year-on-year in January from 9.1% a month earlier.
The latest inflation figure makes it the third straight month that inflation has fallen in the East African country. The figure hit 9.6% in October, its highest level since May 2017. January's inflation is still above the government's preferred band of 2.5%-7.5%.
The statement by the Kenya National Bureau of Statistics shows that on a monthly basis, inflation was 0.2% compared with 0.5% in December.
Inflation inched down to 9.1% in December, the second straight month of decrease, but still above the government's preferred band of 2.5-7.5%.
Kenya's central bank on Monday announced a new monetary policy holding its benchmark lending rate steady at 8.75%.
According to African Development Bank, Kenyan economic growth is projected to decelerate to 5.9% in 2022 and 5.7% in 2023, driven on the demand side by a decline in domestic and external demand caused by lower income and by an increase in food and fuel import costs and on the supply side by tepid economic activity across sectors due to cost-push factors.
Nigeria's debt crisis isn't going away anytime soon as the country's lower house of parliament has approved President Muhammadu Buhari's request to borrow an extra $2.2 billion.
According to the lawmakers, the approval is in temporary advance from the country's central bank.
Nigeria's minister of Finance in December made the revelation that the country will henceforth focus on concessionary loans from the World Bank, Islamic Development Bank, African Development Bank, and others for external loans, Ahmed told Reuters in Abuja after a cabinet meeting.
The legislators plan to discuss with officials in order to turn central bank loans to the government worth 23.7 trillion naira ($52 billion) into long-term debt.
President Buhari asked parliament in December for approval to convert central bank's temporary advance to government into 40-year bonds at 9% interest to cut interest payments but lawmakers questioned the plan.
Government debt in Nigeria averaged 73641.06 USD Million from 2012 until 2022, reaching an all-time high of 103312.80 USD Million in the second quarter of 2022 and a record low of 48361.37 USD Million in the first quarter of 2013.

redpajama_set_name: RedPajamaCommonCrawl


We're crafting a Diamond Ore on June 29th, 2014 from 1pm – 3pm!
We are supplying the cube canvas, the lights, the paint, and the instruction on how to create your very own lighted Diamond Ore!
Bring all your friends or parents, bring your kiddos, and come pARTy with us!


text:
using namespace std;

MemList::MemList() {
  list = vector<MemPtr>();
}

MemList::MemList(vector<MemPtr> list) {
  this->list = list;
}

size_t MemList::size() {
  return list.size();
}

string MemList::getAddressAsString(int index) {
  return list[index]->getAddressAsString();
}

Address MemList::getAddress(int index) {
  return list[index]->getAddress();
}

string MemList::getValue(int index, const string& scanType) {
  if (index >= (int)list.size()) return "";

  PemPtr pem = static_pointer_cast<Pem>(list[index]);
  return pem->getValue(scanType);
}

string MemList::getValue(int index) {
  if (index >= (int)list.size()) return "";

  PemPtr pem = static_pointer_cast<Pem>(list[index]);
  return pem->getValue(pem->getScanType());
}

void MemList::dump(int index, bool newline) {
  list[index]->dump(newline);
}

string MemList::getScanType(int index) {
  if (index >= (int)list.size()) return "";

  PemPtr pem = static_pointer_cast<Pem>(list[index]);
  return pem->getScanType();
}

void MemList::setValue(int index, const string& value, const string& scanType, bool isStored) {
  if (isStored) {
    SemPtr sem = static_pointer_cast<Sem>(list[index]);
    sem->setValue(value, scanType);
    if (sem->isLocked()) {
      sem->setLockedValue(value);
    }
  } else {
    PemPtr pem = static_pointer_cast<Pem>(list[index]);
    pem->setValue(value, scanType);
  }
}

void MemList::setScanType(int index, const string& scanType) {
  PemPtr pem = static_pointer_cast<Pem>(list[index]);
  pem->setScanType(scanType);
}

int MemList::getLastIndex() {
  return list.size() - 1;
}

void MemList::sortByAddress() {
  MemList::sortByAddress(list);
}

void MemList::clear() {
  list.clear();
}

void MemList::setAddress(int index, const string& address) {
  list[index]->setAddress(hexToInt(address));
}

vector<MemPtr> MemList::sortByAddress(vector<MemPtr>& list) {
  sort(list.begin(), list.end(), [](MemPtr a, MemPtr b) {
      return a->getAddress() < b->getAddress();
    });

  return list;
}

void MemList::sortByDescription() {
  MemList::sortByDescription(list);
}

vector<MemPtr> MemList::sortByDescription(vector<MemPtr>& list) {
  sort(list.begin(), list.end(), [](MemPtr a, MemPtr b) {
      auto sem_a = static_pointer_cast<Sem>(a);
      auto sem_b = static_pointer_cast<Sem>(b);
      return sem_a->getDescription() < sem_b->getDescription();
    });

  return list;
}

MemPtr MemList::getMemPtr(int index) {
  return list[index];
}

void MemList::addMemPtr(MemPtr mem) {
  list.push_back(mem);
}

void MemList::setList(const vector<MemPtr>& list) {
  this->list = list;
}
vector<MemPtr>& MemList::getList() {
  return list;
}

void MemList::addNextAddress(int index) {
  auto mem = list[index];
  SemPtr semPtr = static_pointer_cast<Sem>(mem);
  SemPtr newSem = Sem::clone(semPtr);

  int step = scanTypeToSize(semPtr->getScanType());
  Address addr = semPtr->getAddress();
  newSem->setAddress(addr + step);
  newSem->setDescription("No description");

  list.push_back(newSem);
}

void MemList::addPrevAddress(int index) {
  auto mem = list[index];
  SemPtr semPtr = static_pointer_cast<Sem>(mem);
  SemPtr newSem = Sem::clone(semPtr);

  int step = scanTypeToSize(semPtr->getScanType());
  Address addr = semPtr->getAddress();
  newSem->setAddress(addr - step);
  newSem->setDescription("No description");

  list.push_back(newSem);
}

void MemList::shiftAddress(int index, long diff) {
  auto mem = list[index];
  Address addr = mem->getAddress();
  mem->setAddress(addr + diff);
}

void MemList::deleteAddress(int index) {
  list.erase(list.begin() + index);
}

redpajama_set_name: RedPajamaGithub


text:
Actor LeVar Burton Starts A Book Club With The Social Reading App Fable
The first novel will be James Baldwin's "Go Tell It on the Mountain" for his book club.
By Giana Levy
(Photo: Astrid Stawiarz/Getty Images for the Audio Publisher Association)
LeVar Burton has launched a book club!
The storied actor created the LeVar Burton Book Club in partnership with Fable, as described on its app and website as a means to discover, read and discuss books, and help build "human connections," according to Yahoo News.
"As a lifelong advocate for literacy, the opportunity to launch my book club on Fable's wonderful new platform is extremely exciting and timely," Burton said in a statement Tuesday. "This partnership will help foster the importance of storytelling while sharing my love of reading."
Burton, whose advocacy and encouragement of literacy created in young viewers the love of books with PBS' "Reading Rainbow," now hosts the podcast "LeVar Burton Reads." Burton chose James Baldwin's "Go Tell It on the Mountain" as his first selection for Fable. Octavia Butler's "Parable of the Sower" and "The Fire This Time," a poetry and essay collection edited by Jesmyn Ward are next on his list.
In addition to starting a book club, Burton will serve as a guest host on Jeopardy.
RELATED: LeVar Burton Will Guest Host 'Jeopardy'
The quiz show, which lost its longtime host Alex Trebek to cancer last November, has yet to announce a successor. Fans of Burton have lobbied for him to be the permanent replacement, with a petition drive attracting more than 250,000 signatures so far.
celebrity newsLeVar Burton


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Listing courtesy of Main Street Real Estate Group.


text:
Contents 12
National expression
There are many ways for a nation to make a name for itself and build international brand equity. From winning a place on the Olympic podium to positioning itself as a must-stop hub, the options are plentiful, but the results are not always guaranteed.
In the past year 15,000 Venezuelans have fled Hugo Chávez's regime to settle in Panama. They are not alone. Attracting everyone from US retirees to multinationals, Panama is emerging as Latin America's most vibrant and strategic centre.
So long, Serbia
On 17 February the Assembly of Kosovo declared independence and the war-torn state became free from Serbian rule. Monocle was there as the people hit the streets. Also, overleaf, Nader Mousafizadeh, former special assistant to Kofi Annan, offers his road map for the new nation.
Americas briefing
Why China is miffed with Canada, and Mexico's solution to groping on public transport.
Africa/Middle East briefing
Africa's first mosquito net factory, uranium mining, and why Uganda's ruler is keeping it in the family.
Asia briefing
The empty schools of Japan, bridging Hong Kong and searching for a new Seoul in Yongsan.
Gulf champions
Qatar may be small, but with a GDP of €46bn it has the money to pull off minor miracles. Its latest plan is to become one of the world's leading sports nations and to host the 2016 Olympic Games. The motivation is simple: to promote brand Qatar.
Oceania briefing
Why Australia's new gay Malaysian-Chinese MP is the politician to watch, and making high-rise healthier.
Street talker
Her parents are from Algeria and she has spent her life working for radical campaign groups, but now Fadela Amara is at the heart of government in France. Her challenge from President Sarkozy: rebuild France's riot-hit suburbs.
Cape crusader
Nato, the EU, the Chinese, the US, property developers and private jet owners looking to refuel: it seems suddenly everyone wants to be Cape Verde's friend. That's because despite being resource-poor, the islands have one asset: a powerful strategic location.
George Town, on the Malaysian island of Penang, was a colonial trading hub but after the Second World War it lost out to Hong Kong and Singapore. Now its faded Art Deco villas and relaxed pace of life are luring a new generation of international entrepreneurs.
The new deli
The centre of Germany's second-largest city used to be known for its drugs and sex shops. Now, with ongoing gentrification, comes a retail concept that combines local organic produce with slick design.
The coffee shop favoured by US troops, Dubai's building bottleneck, and mobile firms reveal their new organic deli.
Mitsubishi built Tokyo's first office block, in the Marunouchi district, 114 years ago, and the firm is behind the area's current redevelopment into a major financial centre. Overleaf, we dissect a Marunouchi building site.
Site seeing
Once a nondescript office area with little in the way of shops or restaurants, Marunouchi in Tokyo is undergoing the latest stages of a 20-year transformation into a vibrant retail and financial centre. The next phase will see the building of Mitsubishi's Marunouchi Park Building, which includes a 34-floor office tower, shops, a rose garden and an art gallery housed in a replica of Mitsubishi's first office building.
Gilt trip
Financial markets are gripped by gold fever – it could soon hit $1,000 an ounce. Key to this secretive trade are the daily bullion flights between the world's leading financial hubs. Welcome aboard Bullion Air.
Hair raising
The Bronner Brothers' first hair show attracted 300 people at a local YMCA. Now one of the largest producers of African American haircare products, their legendary trade shows are part circus, part religious meeting.
After spending a rumoured €273m on a total overhaul, the Dolder Grand is hoping to cement its reputation as the European elite getaway, 109 years after its first guests checked in. But has the Foster redesign retained the original's Mitteleuropean charm?
Presenting the nation
An explosion of state-funded English-language news channels are attempting to transmit not just the news but their country's brand. From Moscow to Mumbai we report on the new broadcast empires and ask if this is just propaganda disguised as programming.
Woman of the world
The next correspondent in our series looking at foreign coverage of the US presidential elections is Corine Lesnes of 'Le Monde'. Once frosty, France's relations with the US have improved with the arrival of President Sarkozy.
Le Thé dans L'Encrier
Situated off this Provençal village's main square, Le Thé dans l'Encrier serves as the sole bookshop to 1,100 inhabitants and myriad tourist
Culture briefing
Books: Richard Sennett's The Craftsman, 1980s Greece and the Imposters. Art: Phillips de Pury's Japanese art sale, the Berlin Biennial and Simon Starling. Film: 21, the King of Kong and Scorsese's Shine of Light. Music: Nick Cave, Envelopes and Monade.
America has the vestiges of a patchwork of local media barons. The ones that thrive have managed to mix tradition with cutting-edge technology. The 80-year-old owner of the 'Free Lance-Star' is still a pioneer and the owner of an empire that rivals covet.
Schiphol, JFK and now Frankfurt airports have all turned to one Dutch designer to create the perfect signage systems. Paul Mijksenaar tells Monocle about his crusade to take the art of wayfinding in a new direction.
A study in scarlet
Andreas Ferm and Jani Kristoffersen founded their practice DRD-A in 2003. Soon to relaunch as Guise, they are taking on ever more ambitious builds but also apply their ingenuity to smaller projects, such as the Stockholm office of photographic agency LundLund.
Salon rangers
Milan's I Saloni – the collective name for the Salone Internazionale del Mobile and its associated offshoots such as Salone Ufficio and SaloneSatellite – are the most important events in the design calendar, with over 2,300 exhibitors and almost 300,000 visitors buying and selling modern design.
Architecture/Design briefing
The new Danish Royal Theatre, Simón Vélez's bamboo, Dutch architect Wiel Arets, a Holocaust memorial and Mexican furniture
Going for old
The Japanese love vintage, but the idea of bidding for second-hand furniture is an unfamiliar concept. Now three entrepreneurs are bringing design classics to a new market in the country's first modern and contemporary furniture auction.
Fashion briefing
Artist-designed sunglasses, tailoring by Italian brand Barbisio, Stockholm store Nitty Gritty and Margret Howell for Baracuta.
Sock appeal
From Lufthansa cabin crew to men about town, more people than ever are keeping their toes warm with Falke's socks and tights. In the first of a series on fashion workhorses we look at the German-based hosier, which in 2006 had an €186m turnover.
Inventory no. 12
A Japanese inn special: the Masuichi Kyakuden Brewery hotel in Obuse, plus our great spring gift guide.
Present sense
As the northern hemisphere heads from winter into spring and the invitations to al fresco celebrations start rolling in, we thought a spring round-up would help take the pain out of purchasing presents.
Night caller
Having converted one spare room into the perfect home office (see Monocle issue 4) we decided to turn our attentions to the guest room. Here we furnish the quarters with best-for-guests accoutrements.
The popularity of 'natural' cosmetics and remedies has burgeoned, and Austria is one of Europe's top markets. In Vienna a group of friends with a passion for botany and herbal medicine are championing the use of local plants in everything from massage oil to health food and have created a collection of well-designed and thriving businesses.
In the 1980s the only deals being done in Cartagena were for cocaine. Now the drugs barons have been kicked out and the property kings are moving in to one of Latin America's most promising cities.
A song for supper
As a shy teenager from an island off Rotterdam, Anton Corbijn only felt confident behind a camera. Described by Bono as the 'fifth member of U2', he has befriended many of the subjects he has shot and filmed in his 30-year career. Corbijn invited us to lunch at his new house in the Vredespaleis area of the Hague, in the benign shadow of The International Court of Justice.
Last year's C40 summit in New York was a good start but the leaders of the world's major cities need to get out even more to keep an eye on the competition and form alliances. London is facing a thin field for its upcoming leadership race.
Expo 12: Airs apparent
From Ulan Bator to Accra, there's a global shortage of pilots – and schools to teach them. That's why business has taken off at Moncton Flight College in New Brunswick, Canada. It's home to 240 students who will one day be captains welcoming you aboard flights for Xiamen Airlines and Mongolia's Miat. But before they can get near an A380, there are 200 training hours to notch up in the Diamond Eclipse, aka the "Flying Sperm".
Cartagena / Colombia
Anastasia Moloney
Luca Zanetti
When asked to pinpoint what makes Cartagena so special, people usually end up comparing this fortressed city with other places. It is like Dubrovnik but in the Caribbean or Cádiz but with better weather. Its courtyards, they say, are reminiscent of Moroccan riads and its narrow cobbled streets like Seville. But it also has probably the biggest concentration of Spanish colonial buildings anywhere in South America.
"You won't find anywhere else in the Americas that has so much beautifully conserved Spanish colonial architecture with remnants of Arab influences on such a large scale as you'll find in the historic centre. It's through this rich legacy that the magic of Cartagena transcends the Old and New worlds," says local architect Fernando Benitez.
After years of neglect during the height of Colombia's cocaine wars of the 1980s, Cartagena is now revelling in a new heyday. Its thriving gourmet scene and al fresco dining, several well-established arts festivals and a burgeoning property market are all part of the city's renaissance. And despite the recent influx of European high rollers and Colombia's elite snapping up properties, the main characters in this city remain its friendly residents – from the fruit and flower sellers, emerald dealers, and university students to the wandering dance groups.
The city has retained its informal, village atmosphere. It's the kind of place you will see neighbours exchanging gossip on street corners, old residents rocking on wicker chairs on porches on a balmy night, impromptu dancing on balconies, and romances kindled on top of the city's ramparts at dusk.
To escape the heat, locals head to the Rosario Islands. A short boat ride from Cartagena, the islets and mangroves of this coral reserve are great for island hopping and diving.
Cartagena is spilt into three distinct districts. During the conquistador era, Spanish merchants made rich on the back of the slave, emerald, and gold trade built elegant mansions in the El Centro and San Diego quarters. Today savvy European investors and Colombia's monied elite either looking for a luxurious holiday home or a lucrative rental investment are descending on these neighbourhoods and buying derelict buildings and restoring them to their former grandeur. They have filled the courtyards with trickling fountains, planted cascading bougainvillea, bleached wood-beamed balconies, retouched white coral stone walls and installed pools and roof-top Jacuzzis at a frenzied pace. Restoration costs will set you back around €1,000 a sq m if renovating a run-down building from scratch.
In the Getesmaní district, the gentrification of one-storey houses once home to African slaves and artisans is less hectic. While prices have soared in El Centro in the past three years, there is still a chance to snap up a bargain in Getesmaní, but the pundits say that will not last for very long.
Calle de la Iglesia 35-76 Billed as the best bakery in town, Mila is a fashionable place to stop for a snack.
Casa Floral, Art Cartagena
Calle Vélez Daníes 4-15 Knowledgeable curator, Norma Uparela, showcases homegrown talent in her studio, including the oil paintings of Alfredo Piñeres, a former maker of rat traps.
Ábaco libros y café
Calle de la Iglesia con Mantilla Esquina 3-86 Frequented by the local intelligentsia, this is a relaxed place to browse art and coffee-table books with wi-fi and a small bar serving coffee as well as Chilean wine.
Parque de las Flores, Avenida Venezuela
Most sellers have been at this street flower market for decades. Find sunflowers, ginger flowers and bird-of-paradise flowers shipped in from the capital.
Lucy's
Edificio Cuesta, Calle Santo Domingo 3-19 Lucy has been on the block for the past 25 years and stocks the shiniest green beryl stones bought directly from Colombian miners. The emerald cutters working in the shop can do made-to-order commissions.
Estudio Morfo
estudiomorfo.com
A much sought-after American-Colombian team who divide their time between Paris and Colombia. They specialise in residential, hotel and retail developments using local craftsmen and materials.
Martha Wiesner and Eduardo Mendez
Busy local architects credited with a range of restoration projects.
Patrick Enste, La Heroica
laheroica.com
Expat Patrick is well-versed in Colombia's attractions and an expert on the local property market.
Rosanna Aranguren Velez, Inverfin
Centro Calle de Ayos Edificio 35-26
Rosanna has 14 years' experience in helping foreigners buy property in Cartagena.
Cultura del Mar
Calle del Pozo 25-95
culturadelmar.com
A group of attentive young Colombians who organise diving trips to the coral reef at Rosario Islands.
Flights to Cartagena:
Continental – one flight daily via Bogotá
From Madrid
Iberia – one flight daily via Bogotá
Air France – one flight daily via Bogotá
Eat+drink
Plaza de la Universidad Situated in the historic centre, find fine Colombian coffee and great croissants.
La Casa de Socorro
Calle Larga 8B-112
+ 57 5 664 4658
The local's favourite. Famed for its seafood dishes and unfussy fare. Order the crab claws or cazuela de mariscos, a creamy seafood soup with a tang of coconut served with plantain cakes.
Vitrola
Calle Baloco 2-01
Vitrola is an institution in Cartagena. It is often packed with well-heeled Bogotános during the holiday season, so book ahead. Expect fresh catch, slick service and a well-stocked cocktail bar.
Calle Media Luna
with Calle del Guerrero Havana has an authentic bohemian vibe and the Cuban bands playing here three times a week draw in the local crowds as well as the odd European yachtsman.
Quiebra Canto
Parque Independencia A regular fixture on Cartagena's nocturnal scene, here you'll encounter a steamy dancefloor taken over by Colombian couples. Its balcony has seats from which to drink the local sweet rum and enjoy a fine view of the city at night.
Café del Mar
Baluarte Santo Domingo, El centro
Its location on top of the city's fortifications makes this one of the best spots for an aperitif at sunset. Bar stools are sandwiched between rusty cannons and turrets with views of the Caribbean on one side, and the floodlit church domes and rooftop terraces of the historic quarter on the other.
Hotel to stay in while house-hunting
Calle de la Mantilla 3-56, +575 664 9100, hotel-lm.com The new kid on the block in the booming boutique hotel scene. A restored 18th century mansion with an eclectic blend of modernist-colonial styles, oversized sun loungers and pool on the rooftop terrace.
Flat to rent while you're house-hunting
Edificio Puesta, Plaza Santo Domingo
Rented by Rosanna at Inverfin estate agents, + 57 310 630 0969
Renovated by Martha Wiesner, the view of the sea and terracotta rooftops overlooking Santo Domingo square and cathedral makes this two-bedroom flat stand out. Use of the pool in the leafy courtyard is included.
Martha Carrascal
"I've lived all my life in Cartagena and I can't imagine living anywhere else. The people make this city what it is. We're a place that welcomes visitors with open arms, where people talk to their neighbours. Just walking around the city is a pleasure. I love to stroll by the old walls at sunset and take in the sea breeze. It's all very romantic."
Yamid Gonzalez
"There's a sense of warmth and joy to be found in this community. Cartagena's a diverse mix – Europeans, Arabs and Africans. The historic centre is like a small town, but I can meet people from all over the world. I like to go to the beaches on the islands at the weekend. It's the best city in the world."
Martin Murillo
Keeper of Cartagena's mobile library
"Cartagena is a city where cultural exchanges take place all the time. There's a constant cycle of activities and entertainment, even when it's not high season. People are always interacting with each other. And it goes against the stereotype of a violent Colombia. You'll find no blood on the streets, but people living peacefully side by side. It's a safe town. Everything I need, I can find within these walls. I like reading in the squares filled with palm trees that keep me cool. At the moment, the old buildings are being renovated and there's a sense of optimism. It's never been so good here."
Carmela Paez
Chef and restaurant owner of La Cocina de Carmela
"I come from a Lebanese family. Cartageneros are a blend of different flavours. People here have cheek-to-cheek smiles. We're happy people. I like to draw on our rich, indigenous heritage and it's important for me to use fresh local produce. There's an abundance of talent and craftsmanship. I rely on our growers for the foods such as seafood, tuna and fruits. Six years ago, Cartagena wasn't opened up to the world. But we're receiving more visitors and I enjoy sharing the best of our local cooking."
Property guide
Average prices for houses
El Centro, the areas around Plaza Santo Domingo, Santa Teresa Hotel and Santa Clara Hotel (prime location)
Unrestored €1,696 – €2,374 per sq m
Restored €3,391 – €4,070 per sq m
El Centro, the areas around Plaza de los Coches and Parque Fernández Madrid
Notary costs 0.35 – 0.5 per cent (of purchase price) split between seller and buyer
Registration duty 1.5 per cent
Government tax 1.5 per cent
Agent's fee 3 per cent, paid by seller
It has become easier for foreigners to buy in Colombia and there are few restrictions. In fact, foreign investment is positively encouraged. You might want to hire a lawyer to navigate the red tape but using a trusted estate agent will often suffice. Probably the easiest way to buy is to wire money directly to the estate agent's bank account. Or you can set up your own Colombian bank account. Alternatively, you can set up a private company to purchase a property. Tight anti-money laundering laws mean you have to prove cash from a foreign account is clean. The matrícula immobiliaria is a crucial document that outlines the history of a particular property including its previous owners and mortgages. This allows you to verify whether the seller is the bona fide owner of the property and if any debts on it have been settled. If in any doubt, hire a lawyer. If you're renovating a ruin from scratch, strict regulations concerning the original façades and layout exist. Expect up to six months for a decision and another 15 months for the restoration.
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text:
As much as 'progressives' would like to think so, the Republican party is not a complete bunch of zealots, wackos, and out-of-touch ideologues because a large proportion of the American people believes what they do. These same 'progressives' blame Romney Ryan, and the gaggle of radical outliers that self-destructed during the primary season for influencing voters; and that somehow the public's views on abortion, gay marriage, family, prayer, and small government do not come from them, but from the minds and mouths of a manipulative, intellectually corrupt, and ignorant few.
Nothing could be farther from the truth. The Statistical Abstract of the United States estimates that 28.6 percent of Americans are evangelical Christians, most of whom hold very conservative social values. A Gallup poll in mid-2011 found that most Americans want abortion illegal:
By a 24 percent margin, 61-37 percent, Americans take the pro-life view that abortions should either be legal under no circumstances or legal only under a few circumstances. Although Gallup doesn't specify those "few" circumstances, polling data has consistently shown that, when asked about cases such as rape, incest, or the life of the mother, a majority of Americans want all or almost all abortions made illegal — leaving only life of the mother or rape and incest as the exceptions.
According to a Gallup poll taken in May 2012, half of Americans object to same-sex marriage, and of those who object, most are extremely opposed. Gallup (2011) also estimated that 43 percent of Americans feel that illegal immigration to the US should be decreased. Over 65 percent of Americans (Rasmussen poll 2011) want to reintroduce prayer in the schools. A recent Washington Post poll (August 2012) found that 55 percent of Americans want smaller government. Gallup also found (August 2012) that 47 percent of Americans feel that their tax burden is too high. A recent (April 2012) found that 55 percent of Americans oppose affirmative action.
To claim that the Republican party is way off base, hostage to right-wing zealots, and pursuing a narrow, self-serving agenda, is not consistent with the facts.
Today's editorial in the Washington Post hammers New Jersey governor Chris Christie for shouting the praises of smaller government, lower taxes, and deficit cutting while presiding over a high unemployment rate. While the Bureau of Labor Statistics confirms that New Jersey's rate is high, a look at their state-by-state figures suggests that there are many factors at work, not just the influence of a governor. For example, Washington and Oregon – Democratic and avowedly 'progressive' states have equally high rates of unemployment. New York and Mississippi have rates that parallel New Jersey's and no two states could be more different. To make the specious correlation between Christie's policies and high unemployment is simply wrong.
There is no doubt that some employment, particularly in the public sector has been lost, but Wisconsin, a state in the press for its policies to reduce the influence of public sector unions, has a much lower rate of jobless. When the county-wide unemployment statistics are examined, all but four of New Jersey's counties have rates that are close to the national average; and the poor rates in the southern counties cannot be due to Christies statewide policies. Employment Spectator, a New Jersey website, has suggested that the reason for the poor performance in the southern counties has to do with poor education and low incomes – in other words, the socio-economic status of these areas is already low and shares some of Mississippi's characteristics.
The factors in each state must be looked at separately and individually and, as above, only a countywide analysis can make sense of the data. Mississippi is the poorest state in the Union, and therefore the high unemployment rate is not a surprise. An economic powerhouse like California has an even higher jobless rate, and that despite its leadership in 21st Century technologies and continuing importance as an agricultural production center.
An analysis of national unemployment figures suggests that something more is going on – structural adjustment. That is, the economy is in a phase of major transition. Manufacturing jobs are rapidly losing out to foreign competitors, low- and semi-skilled jobs are less plentiful because of the shift to a knowledge-based economy, and unemployment will continue to be high until the country as a whole catches up with the revolutionary changes in production. David Leonhardt (New York Times January 2011) suggests that Brad DeLong's definition of structural adjustment is accurate:
You see structural unemployment when there are significant groups of businesses and industries that are frantically raising wages in an attempt to attract more qualified workers while wages in the economy as a whole are stagnant.
The unemployment figures are lower for college graduates than for those with less education:
The ratio of the typical four-year college graduate's pay to a typical high-school graduate's pay hit a record in 2010 — 1.56. Since 2007, the inflation-adjusted median weekly pay of college graduates has risen 1.6 percent. The inflation-adjusted pay of every other educational group — high school dropouts, high school graduates and people who attended college but did not get a four-year degree — has fallen since 2007. The same is true over the last decade; amazingly, only college graduates have received a raise.
It's pretty surprising that college graduates' real pay has risen during a three-year period when the economy was in miserable shape. It seems like a clear indication that our economy has an undersupply of skilled, educated workers. To put it another way, if there were more of these workers than they are, more of them would have jobs today.
This echoes the commonly-heard complaint of American industry – we simply cannot find enough qualified workers in the United States, and jobs that could be created here are being created overseas.
The issue of unemployment is a complex one, and I only mean to suggest that the facile arguments used against Chris Christie are obviously politically-driven and select facts to suit their partisan beliefs.
The GOP platform, then, both reflects the views of a significant number of Americans, and proposes measures accordingly. What is important, however, is to sort political polemic, posturing, and narrow appeals to the real issue of governance. Only with a win in the White House, House, and Senate races will the Republicans be able to pass their most extreme propositions – those that take legitimate conservative sentiments in the populations and radicalize them (e.g. completely privatizing Medicare and Social Security); and even then, a vocal minority will be heard. More than likely the Republicans will have to tone down the expected rhetoric and govern; and they certainly can do so without rejecting the will of their base.
I live in Washington, DC; and as I ride through the federal bureaucratic canyons of the city, I speculate that if one-third of all the jobs were eliminated at random, we would probably be better off, not worse off. In other words, if we were to objectively analyze the nature of each job and assess if and how it is contributing to the stated goal described for it and at what cost, we would certainly be able to eliminate thousands of jobs. If I travelled the few miles to Virginia and looked at the Pentagon, I know I could cut thousands of jobs without even getting to reductions in military hardware. I know that I could achieve billions in savings if I raised the Medicare and Social Security age of benefits by a year and tightened the restrictions on Medicaid.
With these cuts, I would not even need to look at EPA, FDA, the Departments of Education and Energy – frequent targets of Republicans.
In short, there is a reasonable way to to the business of cutting. Admittedly, there is a bi-partisan impasse in being able to take this logical Gregg-Simpson approach; but it is the political compromise that may be required if either party fails to dominate the election.
In conclusion, I feel that the Republicans represent – not create – public opinion which is favorable to many if not most GOP policies. Secondly, I feel that we are still in the fulminating, posturing stage of the electoral process when the most extreme positions are still reflected; and finally, some compromise, no matter how significant the majority, will inevitably move the Republican closer to the center.


reserve a place by sending a message via our Contact us form. - Sorry, all seats taken now!
setting below the SW horizon and it being dark enough!
At the Wembury Beach car park (map on the Join us page), 7.30pm onwards.
At the Wembury Beach car park (map on the Join us page) at 8pm.
At the Wembury Beach car park (map on the Join us page).
At the Wembury Beach car park (map on the Join us page), 7pm.
At the Wembury Beach car park (map on the Join us page), 7.30pm.
Raffle, Birthday Cake and Refreshments!
Here is a short video on safe ways to view the Sun.
At the Wembury Beach car park (map on the Join us page), 8.00pm onwards.
Arrive early with your equipment and get advice on astrophotography and observing.
There is no "talks" meeting in August 2015.
The next meeting will be on Friday 11th September 2015.


text:
overnights July 13, 2012
Louie Recap: Mano a Mano
By Zach Dionne
Male bonding in Miami on Louie Photo: FX
Here are some things Louie and his new amigo Ramon do in Miami: Lie on the sand after Louie's non-drowning incident; share a drink and some smiles at the hotel bar; relate their stories of immigration; share a bicycle; sip beverages from green coconuts; laugh; fix up the bicycle a little; laugh some more, or possibly giggle; MERRILY CHASE CHICKENS; smoke cigars; take a happy swim together; toss a football around and roughhouse in the surf; have a terribly confusing conversation about where all this has led them.
"There's a lot of things that we maybe could do that might be nice, but we can't 'cause someone will think we're gay," Louie says in the stand-up epilogue to "Miami." It's hard not to wonder if, with this observation in mind, C.K. simply sketched a list of activities he and his handsome companion could enjoy in blissful, fictive ignorance of society's assert-heterosexuality-at-all-times-always mandate.
"It's rare to see anyone depict the awkward intimacies of straight-guy bonding this nakedly," wrote Rolling Stone's Rob Sheffield. "It's the bromance Lost in Translation." That captures it terrifically. This is an episode quietly adventurous and contemplative in the indie-film fashion Louie adopts when it's at its best, and there is literally so much lost in translation between these two guys.
Part of the courage on display here is C.K.'s attempt — in an installment already set out of his NYC comfort zone — to let the sights tell the story. Many of Louie and Ramon's bonding moments come in a mid-episode travelogue of "real Miami." Few, if any, comedian-centric TV shows have relished visual presentation so openly. Louie gets sniped by commenters around the web for what they perceive as his "first-year film school student sensibilities," by folks perhaps willfully unaware that C.K. is by trade a stand-up comedian and by choice the showrunner of a starkly low-budget series attempting to do unusual things. This montage is sumptuous, it serves the episode well, and most important, it's fun.
The first five minutes of this episode are nearly entirely sans dialogue. But even with this strong visual focus, C.K.'s dialogue writing is concise and sneakily hilarious. "I'll stay here with you for a bit," Ramon tells a saltwater-spluttering Louie, an introduction loaded with double meaning. Later, Louie tells Ramon, "I wasn't drowning, but I'm glad you saved me." It's a fine line on its face, or a fantastically corny metaphor some blonde said to someone tall and dashing onscreen in the nineties a bunch of times.
That last comment comes when Louie thinks he's seen Ramon for the last time. There's no doubt about it: Dude misses his bro. A few hours ago he was riding around in a sweet car full of cool guys, heckling passersby in Spanish, being whistled at by cars of cute ladies, and now he's back in the hotel room where he earlier ordered a sandwich, took a few bites, fell asleep, woke up, and finished the sandwich. What kind of cruel life is this? So Louie calls Janet, who is still his ex-wife (continuity!) and still great at running a conversation with him. He did "meet someone," and it took Janet's nudging for him to realize it. Louie's exasperation at the end of this exchange is pricelessly believable. Even three years after a divorce, Janet knows Louie better than he knows himself. And that's the least of his worries as he now hunkers down to spend a night dealing with the idea that he just asked his ex to take care of their kids so he could spend a little more time getting to know someone special, and that that someone special is a man.
The time comes to sort out all these feelings. Back at the hotel bar, site of their first man-date, Louie and Ramon finally pierce the balloon of awareness and realize the G-word needs to be said, the "are you G" question has to be asked. Out comes the buffet of gestures and shrug-offs and false starts. (If Miguel Gomez hadn't won you over yet, this scene brought it home. Wonderful performance. Just wonderful.) This is some of the most blatantly silly dialogue C.K.'s given himself in a while. His most complete thought while dancing through this minefield of social propriety is: "I'm not, okay, like, like, I don't judge anybody, right, but, and I'm not, okay, first of all, I have zero anything, okay?" As we learned in episode one, Louie is a ninja of saying nothing. There's no way his mouth is going to deliver something as simple and true as the fact that he likes spending time with Ramon. And there's no way in hell he's going to say something as blunt as "I'm not gay, man."
So, in what felt to me like an ambiguous closer, Louie resigns to something. He may be giving in to the misunderstanding, very possibly saying (without saying; again only by showing), yeah, sure, I'm gay because he's so exhausted defending his heterosexuality when he just wants to hang out with his new buddy. He adds a stand-up coda about the perils of constantly defending his stance as a male heterosexual. It's a great kicker to assure us Louie will no doubt be back in his cocoon of loneliness and fumbling starvation for companionship next week.
Stray Observations
• "Can I get a thing, brown, shot," Louie asks at the bar, resurrecting his deeply uncool attempt at ordering a whiskey in last season's finale — "just, please, a brown liquid that makes people feel differently than if they didn't drink it."
• We're operating at a rate of at least 50 percent of Louie's screen time involving eating.
• Can we talk about Louie's glasses? And his audacity at just wearing those things and not addressing it?!
• Louie joining the neck-brace-wearing, blobby-bodied crowd of Olds overtaking the beach at dusk, and only then ditching his stalwart black T-shirt, was a sad, sad victory.
• Having breakfast and reading by the pool is one of the only times we've ever seen Louie relaxing without anxiousness. So he has to get riled up over an entitled bikini babe snatching his strawberry.
• Discounting the stand-up outro, the episode showcases exactly one (terribly unfunny) shred of an onstage bit from Louie: "I know it's not popular to say, but I hate balloons."
• That goofy flight attendant voice over the PA had to be C.K., right?
• Viewers used to C.K.'s absurdities may shrug off Louie's tale of coming to the U.S. from Mexico as a youngster, but it's factual.


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CAIRO – Egypt has launched a program of having Muslim clerics read a standardized government-written sermon at Friday prayers, a move by the state to tighten control over religious discourse.
The minister for religious endowments, Mokhtar Gomaa, gave the first such set sermon Friday at Cairo's Amr ibn al-As Mosque. He read from a paper a sermon against corruption, titled, "Bad money is a lethal poison."
Over the past three years, the ministry gave clerics outlines of subjects for their sermons during weekly communal prayers. Now a committee of state-hired scholars will write each week's sermon for clerics to read word-for-word.
Gomaa defended the move as aimed at filtering out extremism and promoting reform. However, critics say it is a new move by President Abdel-Fattah el-Sissi's rule to stifle freedom of expression.


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negate {SparkR}	R Documentation

negate

Description

Unary minus, i.e. negate the expression.

Usage

## S4 method for signature 'Column'
negate(x)

negate(x)

Arguments

x

Column to compute on.

Note

negate since 1.5.0

See Also

Other normal_funcs: Column-class,
column, column,
column,
column,character-method,
column,jobj-method; abs,
abs,Column-method;
bitwiseNOT, bitwiseNOT,
bitwiseNOT,Column-method;
expr, expr,
expr,character-method;
greatest, greatest,
greatest,Column-method;
ifelse, ifelse,Column-method;
is.nan, is.nan,Column-method,
isnan, isnan,
isnan,Column-method; least,
least, least,Column-method;
lit, lit,
lit,ANY-method; nanvl,
nanvl, nanvl,Column-method;
randn, randn,
randn, randn,missing-method,
randn,numeric-method; rand,
rand, rand,
rand,missing-method,
rand,numeric-method; struct,
struct,
struct,characterOrColumn-method;
when, when,
when,Column-method

Examples

## Not run: negate(df$c)

[Package SparkR version 2.1.0 Index]


text:
Riverside Museum
Scottish 'Breaking Bad' star helps launch sponsored walk for Beatson Cancer Charity
Ambassador Laura Fraser is encouraging people to get involved, don their brightest yellow fancy dress and take part in the fun event in August.
Rebecca Parker
The Breaking Bad star will join supporters of the charity by dressing in yellow to raise funds (Image: John James)
You may remember her face from one of the biggest TV series to hit our screens in recent years.
Now, Scottish actress Laura Fraser is helping one of the country's leading cancer charities launch its annual sponsored walk to raise vital funds for patients and families affected by cancer.
Beatson Cancer Charity is going 'Off The Beatson Track' once again and is appealing to everyone who has been touched by the wonderful care and support provided by The Beatson West of Scotland Cancer Centre to get involved and don their best and brightest yellow fancy dress to take part in this fun-filled event on Sunday 28th August.
To launch the event the Glaswegian actress and Ambassador for Beatson Cancer Charity, famous for her many roles including Lydia in the crime drama Breaking Bad, joined supporters of the charity, former patients of The Beatson and family members to take a walk by Kelvingrove Museum, one of the iconic landmarks on the route, in their fun yellow fancy dress.
Glasgow Men's 10k at the Riverside Museum celebrates 10 years this weekend
Commenting on the event, Laura said: "It's an honour to be part of this special event. Cancer affects the lives of so many people and Beatson Cancer Charity does such a wonderful job at helping make those difficult times families face that little bit easier. That's why I will be going 'Off The Beatson Track' to celebrate the charity's amazing success. Anyone can sign up – family, friends, even dogs!"
Beatson Cancer Charity is going 'Off The Beatson Track' once again (Image: John James)
The six and a half mile walk on fully accessible paths will start and finish at Riverside Museum and take in some of the iconic sights of Glasgow's West End including The Beatson West of Scotland Cancer Centre that the charity works so hard to support. There will be lots of unique and exciting entertainment to keep all the walkers and crowds entertained throughout the day, including a live set from Capital FM Scotland's drive time presenter Garry Spence.
William Oviatt, fundraiser at Beatson Cancer Charity, said: "Over 3,000 people have participated in our Off The Beatson Track event. Last year our fantastic participants raised £140,000 to help support Beatson patients and their families – we're hoping that this year will be even bigger and better. There will be a real party atmosphere on the day and we hope to see a sea of yellow making its way through Glasgow's West End again."
All funds raised from the event will help the charity provide specialist staff posts including nursing, radiography, physics and research based staff as well as funding enhanced medical equipment, innovative service developments and novel research projects and educational initiatives to support the 8000 new patients who attend the The Beatson and its satellite locations each year.
To secure your place, visit the website here.
Watch inspirational footage of amputees abseiling down Glasgow building


SURABAYA, Indonesia/JAKARTA — Indonesian rescuers searching for an AirAsia plane carrying 162 people pulled bodies and wreckage from the sea off the coast of Borneo on Tuesday, prompting relatives of those on board watching TV footage to break down in tears.
The navy said 40 bodies had been recovered. The plane has yet to be found.
"My heart is filled with sadness for all the families involved in QZ8501," airline boss Tony Fernandes tweeted. "On behalf of AirAsia, my condolences to all. Words cannot express how sorry I am."
The airline said in a statement that it was inviting family members to Surabaya, "where a dedicated team of care providers will be assigned to each family to ensure that all of their needs are met".
Pictures of floating bodies were broadcast on television and relatives of the missing already gathered at a crisis centre in Surabaya wept with heads in their hands. Several people collapsed in grief and were helped away.
Yohannes and his wife were at the centre awaiting news of her brother, Herumanto Tanus, and two of his children who were on board the doomed flight.
The Tanus family had been on their way to visit Herumanto's son, who studies in Singapore and who travelled to Surabaya on Monday after the plane went missing.
"He cries every time he watches the news," Yohannes said.
"They are not ours, they belong to God," she said.
"The challenge is waves up to three metres high," Fransiskus Bambang Soelistyo, head of the Search and Rescue Agency, told reporters, adding that the search operation would go on all night. He declined to answer questions on whether any survivors had been found.
It was travelling at 32,000 feet (9,753 metres) and had asked to fly at 38,000 feet, officials said earlier.
Three airline disasters involving Malaysian-affiliated carriers in less than a year have dented confidence in the country's aviation industry and spooked travellers across the region.
Malaysian Airlines Flight MH370 went missing on March 8 on a trip from Kuala Lumpur to Beijing with 239 passengers and crew on board and has not been found. On July 17, the same airline's Flight MH17 was shot down over Ukraine, killing all 298 people on board.
US law enforcement and security officials said passenger and crew lists were being examined but nothing significant had turned up and the incident was regarded as an unexplained accident.
Indonesia AirAsia is 49 per cent owned by Malaysia-based budget carrier AirAsia.
budget operations began in 2002.
Weather was the "triggering factor" in the crash of AirAsia Flight 8501 with icing likely causing engine damage, Indonesian officials said, as rough seas Sunday hampered the search for more bodies and wreckage.


Choosing a single product is really a tough job when you have a lot of options to choose from. That's why we have compiled a list of best metal detector 2017. So you can have a look at the best and choose the one which suits your requirments.
There are plenty of out there, few are good when it comes to underwater metal detector while few are good at other things . Which one should you choose? We'll figure it out soon!
so what is the best metal detector 2017?
Product prices and availability are accurate as of Jan 16 13:50:01 UTC but are subject to change. Any price and availability information displayed on the merchant site at the time of purchase will apply to the purchase of this product.
Professional Mode Audio characteristic. Excessive-Res Iron Discrimination. Digital Goal ID. Can be utilized in underwater as much as 10-foot depth.
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This metal detector helps you dig extra treasure and fewer trash.
Dimensions: 11L x 8.5W x 51H in.. Very best for professionals. Pulse-width modulation, digital pinpointing. 5 search modes. Eight sensitivity, depth changes. Coin depth indicator, digital goal ID.
Contains search coil, ACE environmental cowl up, search coil cowl, and Simple stow headphones.
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Maximize your treasure looking at an inexpensive price with the TREASUREPRO.
In contrast to the preset floor steadiness on most comparable metal detectors, TreasurePro's true Computerized Floor Steadiness adapts to floor situations as you hunt for elevated depth and sensitivity to small targets.
With 6 search modes and a giant VDI quantity within the middle of the show, you will be looking like the professionals very quickly! Contains 2 x AA Batteries and Bullseye II Pinpointer.
Enjoy a relaxing and enjoyable pastime with the Fortune Finder 3020 Metal Detector.
Hunt for cash, relics, jewellery, gold and silver nearly wherever.
The Fortune Finder TC-3020 metal detector set consists of every thing it is advisable to seek for buried treasure. It options three distinctive alerts for several types of metal, ferrous/non-Ferrous discriminator distinguishes iron/metal from silver/gold.
One-Contact auto-tune and really low frequency design for correct detection. Operates on two 9-Volt batteries (not included).Comes with BONUS sand-sifting scoop and carrying case and headset. Size adjusts from 41 Inch to 48 Inch.
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NAPOLEON COIN IN THE US & SILVER // METAL DETECTING!!
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GOLD BRACELET FOUND METAL DETECTING!!
I found this gold bracelet while metal detecting near a old creek close to this very old town.