text:
Of Sound Faith: An Interview with Violinist and Educator Ruth Tumpalan
September 16, 2019 | Tyran Grillo
Sing unto him a new song; play skilfully with a loud noise.
For the word of the LORD is right; and all his works are done in truth.
Born and raised in Manila, Philippines, violinist Ruth Tumpalan is a dedicated musician and educator. She is currently a faculty member at the Lindeblad School of Music, where her pedagogical zeal has earned her a place of distinction in the hearts of students. She has studied with such renowned classical artists as violinist Christoph Poppen and pianist Gilles Vonsattel, and has performed with a range of others across genres, from Jaime Laredo to Michael Bublé. Most recently, she won first place in the American Protégé International Piano and Strings Composition, and as a result of that honor was a featured soloist at Carnegie's Weill Recital Hall in New York City. Her focus on cultural diversity is paramount and drives her to constantly improve her technique in all areas.
Yet behind the glamour of performing on some of the world's most hallowed stages, Tumpalan has found special fulfillment as part of the music ministry at Heritage Baptist Church in Manhattan. Her love of God and music have been intertwined since childhood, and manifest with especial depth in her work with the church's choir as part of a vibrant ministry.
I recently sat down with Tumpalan via Skype to discuss the role of faith in her personal and professional life, asking first about her musical foundations.
"My father is a pastor, so we were all homeschooled, but when I was 10 he enrolled me and my siblings in an extension program at the University of the Philippines to study music. Two weeks later, I was playing in a Christian wedding officiated by my father. Since then, I've always played in church, both as a violinist and choir pianist."
At the age of 12, Tumpalan got the chance to visit the United States with her father while he was touring churches. Upon returning home, she immersed herself in recordings and live performances, all the while cultivating a desire to pursue music as a profession. She went on to earn her Bachelor of Music degree at the University of the Philippines, with a focus on violin, graduating cum laude in 2009.
"After college, I played with the Philippine Philharmonic Orchestra, but after five years decided I wanted to develop myself even further through study. I had been praying since high school for an opportunity to study abroad, ideally in the U.S., in pursuit of new perspectives and higher standards. In 2014, God led me to a full scholarship to earn a Master's degree at the University of Massachusetts."
Tumpalan doesn't take such blessings lightly and has always seen her gifts as God-given. While at UMass, however, she found herself at an impasse.
"There I was, halfway through my two-year program, contemplating what the Lord's real will was for me. Did he want me to go back to the Philippines or did he have something bigger in store? It was a long journey, filled with prayer. But God provided, one step at a time, lining me up with a job before I even finished my degree. Although music had originally led me here to the U.S., I know in hindsight that it was actually God's provision all along, working through all the little things to get me where I am now."
Although Tumpalan's husband was in Hong Kong at the time, he also earned a scholarship to study percussion at UMass, bringing them closer under an unseen but ever-felt guiding hand. They were further led to Heritage Baptist Church, where Tumpalan became immediately involved in the music ministry.
"Playing at Heritage is my priority. My job is important, but I like the need of going to church and being with brethren. It also enhances my career, leading me with strength through daily life and its many decisions. When I don't go to church, even for just a week, I feel that my well-being is lowered."
(Tumpalan performs at Heritage Baptist Church)
And what, I asked, of her experience playing at Carnegie?
"I never thought I would get to play there as a soloist. I'd played there before with the Philippine Philharmonic, and thought that was going to be a once-in-a-lifetime experience. But then, last year, I was working with an excellent pianist named Jongsun Lee, who suggested we try out for the competition. With my full studio schedule, it wasn't easy to manage practice time and teaching, but my teaching actually helped me to prepare. Certain things my own teachers had taught me before suddenly made sense. I never expected to get first place, but God made it possible."
For that performance, she chose Henryk Wieniawski's formidable Scherzo Tarantelle Op. 16, a work brimming with the very excitement that stokes her appreciation for music as a means of communication.
"The best feedback I've ever gotten as a musician is being told that I moved someone to tears. In that respect, in my playing I aim to be more of an inspiration, to connect with people at a level beyond words."
This approach is integral to Tumpalan's teaching, which builds upon the renowned methods of Shinichi Suzuki.
"I always make sure to explain to parents that the Suzuki method was designed to create better human beings through music, and that the most important things to learn from the experience are discipline, empathy, and cooperation. These are more than musical skills; they're life skills. Without them, playing well and achieving success in music mean nothing. Whenever someone makes a mistake in my group classes, no one is allowed to point. They must respect themselves, first and foremost."
As for the future, Tumpalan sees herself becoming even more involved in the church, and has been considering putting together a book of Christian music arranged for various instruments. Whatever may come, her faith will only continue to grow.
Praise ye the LORD. Praise God in his sanctuary:
praise him in the firmament of his power.
Praise him for his mighty acts:
praise him according to his excellent greatness.
Praise him with the sound of the trumpet:
praise him with the psaltery and harp.
Praise him with the timbrel and dance:
praise him with stringed instruments and organs.
Praise him upon the loud cymbals:
praise him upon the high sounding cymbals.
Let every thing that hath breath praise the LORD.
Dominique Pifarély: Time Before And Time After (ECM 2411)
June 29, 2019 | Tyran Grillo
Time Before And Time After
Dominique Pifarély violin
Recorded in concerts in September 2012
at Auditorium Saint-Germain, Poitiers (France)
and in February 2013
at Cave Dimière, Argenteuil (France)
Engineer: Gérard de Haro
Here is a place of disaffection
In a dim light: neither daylight
Investing form with lucid stillness
Turning shadow into transient beauty…
–T. S. Eliot, "Burnt Norton"
After leading a string of caravans across the sands of ECM, Dominique Pifarély enchants on this set of solo recordings taken from French concerts in 2012 and 2013 at Auditorium Saint-Germain (Poitiers) and Cave Dimière (Argenteuil). Although nearly everything is improvised, the violinist dedicated each piece in retrospect to a certain poet, from whose verses he also chose a title. More than highlighting personal connections between literature and music, this artistic decision reveals an agency of spontaneous creation.
The Near Eastern quality of "Sur terre" (for Mahmoud Darwich) makes for a poignant introduction to this border zone where motifs converse for want of being equally heard. Every color and texture is like the seed of a new community, touched by horizons yet to be unfolded, and in this respect shares kindship with "L'air soudain" (for André du Bouchet). The latter's robust yet plaintive cry yearns to be acknowledged in a place uninhabited except by its own singing. Arid climates are evoked in the rasp of a bow: a gargantuan tongue scraping along the earth in search of nourishment but finding only dust and ruins.
"Meu ser elástico" (for Fernando Pessoa) and "D'une main distraite" (for Henri Michaux) are both jagged wonders, wherein leaping suggestions of dance are constantly pulled back to origins, while the masterful"Gegenlicht" (for Paul Celan) shows us thefull scope of Pifarély's technical and artistic capabilities. Like a prisoner who succeeds in digging his way through a wall with bare hands, he peels away the barrier to freedom one granule at a time. But before he inhales fresh air again, he must pass through "Violin y otras cuestiones" (for Juan Gelman). A struggle that is as political as it is personal, it finds temperance only in the sul ponticellosalvations of "Avant le regard" (for Jacques Dupin) and "L'oubli" (for Bernard Noël).
If shades of the Baroque are present, they're no illusion, as even Pifarély admits: "[O]f course Bach is in the air because Bach is polyphonic, and the violin is polyphonic." Bach also informs his decision to close his solo performances with a standard—in this instance Victor Young's "My Foolish Heart"—to assert the violin's autonomy. His interpretation thereof looks in the proverbial mirror, hoping to recognize itself but instead finding awe in what it has become.
Curtis Stewart review for All About Jazz
April 11, 2016 | Tyran Grillo
Check out my review of this phenomenal new album by violinist Curtis Stewart, who blends classical and jazz influences with equal rigor. Click the cover to read on.


text:
package com.jaxio.celerio.model.support.jpa;

import com.google.common.collect.Iterables;
import com.jaxio.celerio.configuration.entity.CacheConfigGetter;
import com.jaxio.celerio.model.Attribute;
import com.jaxio.celerio.model.AttributePair;
import com.jaxio.celerio.model.Relation;
import com.jaxio.celerio.spi.support.AbstractRelationSpi;
import com.jaxio.celerio.util.AnnotationBuilder;
import com.jaxio.celerio.util.AttributeBuilder;
import org.springframework.util.Assert;

import java.util.Arrays;
import java.util.List;

import static com.google.common.collect.Lists.newArrayList;
import static com.jaxio.celerio.model.support.jpa.JpaConfigHelper.*;

public class JpaToOneRelation extends AbstractRelationSpi {

    @Override
    public boolean compatibleWith(Relation relation) {
        return (relation.isManyToOne() || relation.isOneToOne()) && !relation.isIntermediate();
    }

    @Override
    public String velocityVar() {
        return "jpa";
    }

    @Override
    public Object getTarget() {
        return this;
    }

    public List<String> getAnnotations() {
        if (relation.isComposite() && !relation.isManyToOne()) {
            return Arrays.asList("// TODO: composite one to one");
        }
        AnnotationBuilder ab = new AnnotationBuilder();

        if (relation.isManyToOne()) {
            ab.add(getManyToOneAnnotation());
        } else if (relation.isOneToOne()) {
            ab.add(getOneToOneAnnotation());
        } else {
            throw new IllegalStateException("Expecting a one-to-one or many-to-one association!");
        }

        ab.add(getMapsIdAnnotation());
        ab.add(getCacheAnnotation());

        if (!relation.isInverse()) {
            if (relation.isSimple()) {
                ab.add(getJoinColumnAnnotation(relation.getFromAttribute(), relation.getToAttribute()));
            } else if (relation.isComposite()) {
                ab.add(getJoinColumnsAnnotation(relation.getAttributePairs()));
            }
        }
        return ab.getAnnotations();
    }

    public String getManyToOneAnnotation() {
        addImport("javax.persistence.ManyToOne");
        return new AttributeBuilder( //
                getManyToOneCascade(), //
                getManyToOneFetch()) //
                .bindAttributesTo("@ManyToOne");
    }

    public String getOneToOneAnnotation() {
        addImport("javax.persistence.OneToOne");
        addImport("static javax.persistence.FetchType.LAZY");
        AttributeBuilder ab = new AttributeBuilder();

        if (relation.isInverse()) {
            ab.add(getInverseOneToOneCascade());
            ab.add(getInverseOneToOneFetch());
            ab.add(getOrphanRemoval());
            ab.add("mappedBy = \"" + relation.getInverse().getTo().getVar() + "\"");
        } else {
            ab.add(getOneToOneCascade());
            ab.add(getOneToOneFetch());
        }

        return ab.bindAttributesTo("@OneToOne");
    }

    private boolean hasMapsIdAnnotation() {
        return !relation.isComposite() && !relation.isInverse() && relation.getFromAttribute().isInPk();
    }

    public String getMapsIdAnnotation() {
        if (hasMapsIdAnnotation()) {
            AttributeBuilder ab = new AttributeBuilder();
            if (relation.getFromAttribute().isInCpk()) {
                ab.addString("value", relation.getFromAttribute().getVar());
            }
            addImport("javax.persistence.MapsId");
            return ab.bindAttributesTo("@MapsId");
        }
        return "";
    }

    private String getJoinColumnAnnotation(Attribute fromAttribute, Attribute toAttribute) {
//    TODO: investigate why it does not work!, it should according to doc
//          http://webdev.apl.jhu.edu/~jcs/ejava-javaee/coursedocs/605-784-site/docs/content/html/jpa-relationex-one2one.html#jpa-relationex-o2o-uni-mapsid
//
//        if (hasMapsIdAnnotation()) {
//            return ""; // not needed.
//        }
        AttributeBuilder ab = getJoinColumnAttributes(fromAttribute, toAttribute);
        addImport("javax.persistence.JoinColumn");
        return ab.bindAttributesTo("@JoinColumn");
    }

    private String getJoinColumnsAnnotation(List<AttributePair> attributePairs) {
        addImport("javax.persistence.JoinColumns");
        addImport("javax.persistence.JoinColumn");

        List<String> ab = newArrayList();
        for (AttributePair pair : attributePairs) {
            AttributeBuilder joinBuilder = getJoinColumnAttributes(pair.getFromAttribute(), pair.getToAttribute());
            joinBuilder.bindAttributesTo("@JoinColumn");
            ab.add(joinBuilder.bindAttributesTo("@JoinColumn"));
        }

        AttributeBuilder joinsBuilder = new AttributeBuilder();
        joinsBuilder.add("value", Iterables.toArray(ab, String.class));
        return joinsBuilder.bindAttributesTo("@JoinColumns");
    }

    private AttributeBuilder getJoinColumnAttributes(Attribute fromAttribute, Attribute toAttribute) {
        return new AttributeBuilder( //
                getJoinColumnName(fromAttribute), //
                getJoinReferencedColumnName(fromAttribute, toAttribute), //
                getNullable(fromAttribute), //
                getUnique(fromAttribute), //
                getJoinColumnInsertable(fromAttribute), //
                getJoinColumnUpdatable(fromAttribute));
    }

    private String getJoinColumnName(Attribute fromAttribute) {
        return "name = \"" + fromAttribute.getColumnNameEscaped() + "\"";
    }

    private String getJoinReferencedColumnName(Attribute from, Attribute toAttribute) {
        if (relation.isSimple()) {
            if (toAttribute.isInPk()) {
                return null; // convention, not needed
            } else {
                return "referencedColumnName = \"" + toAttribute.getColumnNameEscaped() + "\"";
            }
        }

        // composite => set it in all cases
        return "referencedColumnName = \"" + toAttribute.getColumnNameEscaped() + "\"";
    }

    private String getNullable(Attribute attribute) {
        return attribute.isNullable() ? null : "nullable = false";
    }

    private String getUnique(Attribute attribute) {
        return attribute.isUnique() ? "unique = true" : null;
    }

    private String getJoinColumnUpdatable(Attribute attribute) {
        if (hasMapsIdAnnotation()) {
            return null;
        } else {
            return attribute.isInPk() ? "updatable = false" : null;
        }
    }

    private String getJoinColumnInsertable(Attribute attribute) {
        if (hasMapsIdAnnotation()) {
            return null;
        } else {
            return attribute.isInPk() ? "insertable = false" : null;
        }
    }

    public String getCacheAnnotation() {
        CacheConfigGetter localConf = null;
        CacheConfigGetter globalConf = null;

        if (relation.isManyToOne()) {
            localConf = relation.getFromAttribute().getColumnConfig().getManyToOneConfig();
            globalConf = relation.getFromEntity().getConfig().getCelerio().getConfiguration().getDefaultManyToOneConfig();
        } else if (relation.isOneToOne()) {
            if (!relation.isInverse()) {
                localConf = relation.getFromAttribute().getColumnConfig().getOneToOneConfig();
                globalConf = relation.getFromEntity().getConfig().getCelerio().getConfiguration().getDefaultOneToOneConfig();
            } else {
                localConf = relation.getFromAttribute().getColumnConfig().getInverseOneToOneConfig();
                globalConf = relation.getFromEntity().getConfig().getCelerio().getConfiguration().getDefaultInverseOneToOneConfig();
            }
        }

        return JpaConfigHelper.getCacheAnnotation(this, localConf, globalConf);
    }

    private String getOrphanRemoval() {
        return orphanRemoval( //
                relation.getInverse().getFromAttribute().getColumnConfig().getInverseOneToOneConfig(), //
                relation.getFromEntity().getConfig().getCelerio().getConfiguration().getDefaultInverseOneToOneConfig());
    }

    // ----------------------------------------
    // CASCADE
    // ----------------------------------------

    private String getManyToOneCascade() {
        Assert.isTrue(relation.isManyToOne());
        return jpaCascade(this, //
                relation.getFromAttribute().getColumnConfig().getManyToOneConfig(), //
                relation.getFromEntity().getConfig().getCelerio().getConfiguration().getDefaultManyToOneConfig());
    }

    private String getOneToOneCascade() {
        Assert.isTrue(relation.isOneToOne());
        Assert.isTrue(!relation.isInverse());
        return jpaCascade(this, //
                relation.getFromAttribute().getColumnConfig().getOneToOneConfig(), //
                relation.getFromEntity().getConfig().getCelerio().getConfiguration().getDefaultOneToOneConfig());
    }

    private String getInverseOneToOneCascade() {
        Assert.isTrue(relation.isOneToOne());
        Assert.isTrue(relation.isInverse());
        return jpaCascade(this, //
                relation.getInverse().getFromAttribute().getColumnConfig().getInverseOneToOneConfig(), //
                relation.getFromEntity().getConfig().getCelerio().getConfiguration().getDefaultInverseOneToOneConfig());
    }

    // ----------------------------------------
    // FETCH
    // ----------------------------------------

    private String getManyToOneFetch() {
        Assert.isTrue(relation.isManyToOne());
        return jpaFetch(this, relation.getFromAttribute().getColumnConfig().getManyToOneConfig(), //
                relation.getFromEntity().getConfig().getCelerio().getConfiguration().getDefaultManyToOneConfig());
    }

    private String getOneToOneFetch() {
        Assert.isTrue(relation.isOneToOne());
        Assert.isTrue(!relation.isInverse());
        return jpaFetch(this, //
                relation.getFromAttribute().getColumnConfig().getOneToOneConfig(), //
                relation.getFromEntity().getConfig().getCelerio().getConfiguration().getDefaultOneToOneConfig());
    }

    private String getInverseOneToOneFetch() {
        Assert.isTrue(relation.isOneToOne());
        Assert.isTrue(relation.isInverse());
        return jpaFetch(this, //
                relation.getFromAttribute().getColumnConfig().getInverseOneToOneConfig(), //
                relation.getFromEntity().getConfig().getCelerio().getConfiguration().getDefaultInverseOneToOneConfig());
    }
}

redpajama_set_name: RedPajamaGithub


Chris Ducker is the founder of a large-scale services business and an online education business that serves leaders and entrepreneurs.
He has authored two books - 'Virtual Freedom' and 'Rise of the Youpreneur' - and hosts the annual Youpreneur Summit in the UK.
In this interview, we discuss the value of having team members around you who are empowered to call you out when your weaknesses may be exposed..
Chris also shares a story about leaders being lifelong learners, and the power of being interested rather than trying to be interesting.


text:
Q: PHP Include path specifically always at root document I am vague at understanding the include paths and how they are written out, I know how to set them within the ini file and how to functionally do it set_include_path just not how to get it to be exact each time no matter what.
So I have an admin autoload file that I include in all my headers to register the spl_autoload_register function. I just keep getting errors in my error_log file. It says that
PHP Fatal error:  Class 'Configurate' not found in
/home/~username~/public_html/testing_ini.php on line 5

So what I am looking for is how can I set the include path to always be the directory before the public_html directory no matter where I am?
I've tried setting the include path to such
.:/opt/alt/php5/usr/share/pear:/opt/alt/php5/usr/share/phphome/~username~/classes/Configurate.php

But I still get the error. Any help and some tips to understanding this entire thing? I suck at relative paths
As per requested spl_autoload_register function
<?php
$ini = parse_ini_file("configurations.ini",true);
foreach($ini as $section) {
    foreach($section as $key=>$value )  {
        define("__".strtoupper($key)."__",$value);
    }
}

//if(__USERNAME__ == null) {
//  header("Location: /setup.php?step=1");
//  exit();
//}
spl_autoload_register(function($class) {
    try {
        if(!file_exists("../classes/{$class}.php")){
            throw new Exception("/classes/{$class}.php does not exist error on line ". __LINE__." in file ". realpath(__FILE__));
        } else
            require_once "../classes/{$class}.php";
    } catch (Exception $ex) {
        echo $ex->getMessage()."<br>";
        echo $ex->getCode();
    }
});

A: getcwd() and many other methods did not work for me. Though I did find this one method that works great for me in any directory.
set_include_path(
                  dirname( $_SERVER["DOCUMENT_ROOT"] )
                );

Hope this helps anyone else out there looking to get outside the document root and using it like I do.

redpajama_set_name: RedPajamaStackExchange


All About Love: what's in a name?
first of all, thanks to everyone for the baby name love. :) i'm glad that people seem as excited about it as we are!
baby names are, naturally, something that i have had picked out for years. ha! i have had an ongoing list, and when i would see or hear of a name that i loved, i would add it. along with that, i would look up the meaning of the name.
if you know my austin personally, you know that naming her "mighty river" was definitely a word of prophecy over her. ha! she is a strong mighty river, for sure. her daddy never argued about her name. if you ask him, he will tell you that he didn't have a choice. :) that is not true, but he did agree to it from the beginning.
for some reason, i never paid much attention to boy names. they have always been harder for me to like. i never had a boy name picked out that i just loved. ben and i had a couple of ideas when we were pregnant with austin, but nothing stuck. we honestly were so sure that she was a girl, we didn't discuss boy names much. it has been so hard for us to sit down and discuss them this go-around. we couldn't agree on anything, really. we bought a baby name book with over 100,000 baby names, and i thought, surely there has got to be something in there. it did give us some great ideas. some other names that we considered were: william (liam), noah, hosea, conley, conlan, chapman, mayer, creed, and james. in the past, we have also considered adam, alan, and abraham. with every name we thought about, we also considered the meaning of the name.
at first, i thought the name was different, but i didn't just love it immediately. in fact, i never even put it on my name list. when we found out that we were having a boy, ben told me to make a list of what i seriously liked, and we would talk about it. for some reason, i thought of baby bennett, and added "bennett" to the list. i thought that it would be sweet since his daddy's name is benjamin. ben didn't like it. he told me several times to scratch it off of the list. i kept asking him why, and refused to cross it out. "cole" has been on our name list for years as a middle name. it was my great great grandmother's last name (i remember her very clearly with great memories as a child). also, my middle name is nicole, and my family and close friends have called me "ashia cole," "a cole," or "sha sha cole" my whole life. when i changed my name when we got married, my mom even talked to me about changing nicole to cole legally, but i decided not to.
I ADORE thinking of names! I have a whole bunch saved up. :) Austin Rivers is a beautiful name!
I love the name...it is so unique! I'm a fan of unique names! :) It's perfect!


text:
import Vue from 'vue'
import Router from 'vue-router'
import Pos from '@/components/page/Pos'

Vue.use(Router)

export default new Router({
  routes: [
    {
      path: '/',
      name: 'Pos',
      component: Pos
    }
  ]
})


You have quite a few stock. I believe you would be better off with the Boglehead approach. Purchase a S&P index, commission free, and forget about it.
Never have to worry about capital gains, the companies are selected for you. And you always match the market.
We use a Boglehead approach when it comes to my wife's portfolio as we want to keep it simple, but for my portfolio I prefer investing in individual companies and building positions over time and fine tuning depending on how things progress. As time goes by, some industries and companies do better than other – so, I'd rather have control over it. Besides, to full leverage the power of dividend growth, one needs to pick and invest individual companies.
Thanks for stopping by and the input anyway. I value the input.
Same thing with mine, Vanguard for her, dividend growth for me. I feel like we are well diversified at this point.
And I thought I was pretty unique in choosing this strategy 🙂 Good to know you are following the same approach.
R2R, nice list. I like your stocks from your portfolio update. I am looking for something like that to put on my blog, but automate it as I am lazy to look for it and adding it on my blog manually.
I pick my mentions manually…as there can be way too many articles related, esp when there are popular companies like AAPL, GE, T – which sees a lot of publication in the media.
Thanks again for the mention. Performance grids are great visual information. I like to look for opportunities among the biggest losers. I've recently put 3% of the Arbor Asset Allocation Model Portfolio (AAAMP) in Russian stocks. Have a great weekend.
You are welcome, Ken. I agree that the grids are a great visual…I dont usually use the data directly to make investing decisions, but I like to keep an eye on it. Interesting that you've picked Russia – did you pick an ETF? RSX?
Great list as usual. That community stock analysis spreadsheet is awesome. Thank you for the link!
Thanks for the comment. Yes, AFFJ putting that collection of stock analyses and recent buys really helps everyone.
I have 1% positions in Lukoil (LUKOY), Gazprom (OGZPY), and CTC Media (CTCM).
Ah ok. I am not familiar with CTCM. Will check it out. Thanks for sharing.
Thanks for the mention! I love that emerging markets performance, just to show you that great return doesn't happen year after year.
You are welcome, Tawcan. Yeah. I enjoy watching those quilts for countries, sectors etc.


text:
Questa voce raccoglie le informazioni riguardanti l'Associazione Calcio Hellas Verona nelle competizioni ufficiali della stagione 1964-1965.

Rosa

Risultati

Serie B

Girone di andata

Girone di ritorno

Coppa Italia

Statistiche

Statistiche di squadra

Statistiche dei giocatori

1964-1965

redpajama_set_name: RedPajamaWikipedia


text:
Duke Law > Duke Law Scholarship Repository > Journals > DJCLPP > DJCLPP Sidebar > 151
Without More, There Is No More: Standing and Racial Gerrymandering in Wittman v. Personhuballah
Jessica Edmundson
Racial Gerrymandering; Discrimination; Redistricting; Voting Rights Act; Standing
Constitutional Law | Supreme Court of the United States
In drawing election maps, racial gerrymandering separates minority groups, packing them into specific districts to weaken the power of their votes. In Wittman v. Personhuballah, the Supreme Court held that a group of Virginia congressmen that neither lived in, nor represented a district did not have standing to defend gerrymandering in that district. Although the Court had the opportunity to address the substantive issues in the case, it did not, leaving a substantial gap in racial gerrymandering jurisprudence. This commentary explores the consequences of this gap and argues that the Court should not find a legally cognizable right in a politician maintaining the racial makeup of his district, because it would result in non-resident politicians with greater rights than non-resident citizens, and it would further incentivize racial gerrymandering in the drawing of electoral maps.
Jessica Edmundson, Without More, There Is No More: Standing and Racial Gerrymandering in Wittman v. Personhuballah, 12 Duke Journal of Constitutional Law & Public Policy Sidebar 149-161 (2017)
Constitutional Law Commons, Supreme Court of the United States Commons
Available at: https://scholarship.law.duke.edu/djclpp_sidebar/151

redpajama_set_name: RedPajamaCommonCrawl


text:
Redmi K50i 5G, Redmi Buds 3 Lite Set to Launch in India Today: How to Watch
Redmi K50i 5G India launch has been set for today at 12pm (noon). The launch event will be streamed online through Xiaomi India's Twitter, YouTube, Facebook and Instagram accounts as well as its website. The Redmi K50i 5G smartphone has a display that supports Dolby Vision technology. It has already been confirmed that the phone will be powered by the MediaTek Dimensity 8100 SoC. It is also expected that this phone will pack a 5080mAh battery and feature 67W Turbo charging support, which should deliver a full day's charge in just 15 minutes. The upcoming Redmi K50i 5G will also reportedly feature triple rear camera setup with a 64-megapixel primary camera.
As stated above, the Redmi K50i 5G has been set to launch in India today at 12pm (noon). The smartphone is expected to launch in three different colour options: Phantom Blue, Quick Silver, and Stealth Black. The smartphone will be available for purchase on Amazon from July 22, as per a previous report.
Redmi K50i 5G specifications
The Redmi K50i 5G will likely sport a 6.6-inch full-HD+ LCD display with a resolution of 2460×1080. It is expected to have a 144Hz refresh rate. The smartphone's display has recently been teased to support Dolby Vision technology. Also, it has already been confirmed that the phone will feature 67W Turbo Charging. It is said to be able to charge fully in just 15 minutes, according to the company. The battery capacity is said to be 5,080mAh.
Moreover, Xiaomi recently confirmed that the smartphone will be powered by the MediaTek Dimensity 8100 SoC.
The Redmi K50i 5G is expected to feature a 64-megapixel primary rear camera along with an 8-megapixel ultra-wide camera and a 2-megapixel macro camera. For the front, it is expected to have a 16-megapixel camera. The Redmi K50i smartphone is also expected to run MIUI 13 based on Android 12. In terms of connectivity, the Redmi K50i could come feature Bluetooth 5.3 and Wi-Fi 6.
Xiaomi is also expected to announce the availability of the Redmi Buds 3 Lite true wireless earphones in India at the event alongside the Redmi K50i. This will be a relatively affordable pair of in-ear TWS earphones, with a simple design according to teasers posted by the company on Twitter. It should offer up to 18 hours of battery life, environmental noise cancellation, USB Type-C fast charging, and an IP54 rating, as per the company's own pre-launch teasers.
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Home » The Meltdown (Diary of a Wimpy Kid #13) (Compact Disc)
The Meltdown (Diary of a Wimpy Kid #13) (Compact Disc)
By Jeff Kinney, Ramon de Ocampo (Narrated by)
Not on our shelves now, usually available for pick-up or shipping in 1-10 days
This is book number 13 in the Diary of a Wimpy Kid series.
#1: Diary of a Wimpy Kid (Diary of a Wimpy Kid #1) (Hardcover): $14.99
#2: Rodrick Rules (Diary of a Wimpy Kid #2) (Hardcover): $14.99
#3: The Last Straw (Diary of a Wimpy Kid #3) (Hardcover): $14.99
#4: Dog Days (Diary of a Wimpy Kid #4) (Hardcover): $14.99
#5: The Ugly Truth (Diary of a Wimpy Kid #5) (Hardcover): $14.99
#6: Cabin Fever (Diary of a Wimpy Kid #6) (Hardcover): $14.99
#7: The Third Wheel (Diary of a Wimpy Kid #7) (Hardcover): $14.99
#8: Hard Luck (Diary of a Wimpy Kid #8) (Hardcover): $14.99
#9: The Long Haul (Diary of a Wimpy Kid #9) (Hardcover): $14.99
#10: Diary of a Wimpy Kid: Old School (Compact Disc): $19.99
#11: Double Down (Diary of a Wimpy Kid #11) (Hardcover): $14.99
#12: The Getaway (Diary of a Wimpy Kid Book 12) (Hardcover): $14.99
#14: Diary of a Wimpy Kid: Wrecking Ball (Compact Disc): $14.99
#15: Diary of a Wimpy Kid: The Deep End (Compact Disc): $14.99
When snow shuts down Greg Heffley's middle school, his neighborhood transforms into a wintry battlefield. Rival groups fight over territory, build massive snow forts, and stage epic snowball fights. And in the crosshairs are Greg and his trusty best friend, Rowley Jefferson. It's a fight for survival as Greg and Rowley navigate alliances, betrayals, and warring gangs in a neighborhood meltdown. When the snow clears, will Greg and Rowley emerge as heroes? Or will they even survive to see another day?
Publisher: Recorded Books, Inc.
Series: Diary of a Wimpy Kid
Social Themes - General (see also headings under Family)
Sports & Recreation - Winter Sports
Kobo eBook (October 29th, 2018): $13.49
Hardcover (Spanish) (January 15th, 2019): $16.99
Library Binding, Large Print (November 7th, 2018): $28.74
Paperback (Chinese) (May 1st, 2019): $21.19
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HomeAussie News
The Pro-Legalisation Pollies You Should Vote For in the 2020 Queensland State Election
byMitch
Who Should Legalisation Advocates Vote For in the Upcoming Queensland State Election?
The Queensland Greens
Michael Berkman MP
Amy MacMahon
Legalise Cannabis Queensland
Deb Lynch
Josip Zirdum
Shelly Morton
Dr. John Jiggens
Finn Armstrong-Schmakeit
Ian Philp
Edward Carroll (Australian Progressives)
Tim Jerome
Who NOT to Put 'First' on Your Ballot Paper
Queensland Labor
The Liberal National Party
SIGN THE NEW PETITION – Make Some Noise Before QLD Votes!
A mock 'how to vote' card, to assist you on the day.
With a particularly spookygeneral election occurring all across the 'Sunshine State' in late October (on the 31st – Halloween!), FAB has set out to identify the best pro-cannabis candidates across the state. We did this to help our banana-bending readers make the most informed decisions they can, giving QLD (and the rest of the country!) the best possible chances for decriminalisation, law reform and legalisation.
Contrary to popular belief, Queensland may not be as far away from political and legal breakthroughs as we generally imagine. Evidence-based research from the Government itself is in – decriminalisation would plug massive drains on the resources and finances of the state government.Yet, the major political parties, set in their ways and vested interests, are preventing these common-sense changes… signalling no change.
It's high time. We need to put the pressure on. As a cannabis community, we can make a massive difference together upon the broader social collective… if we have our voices heard.
All of the following candidates are pro-cannabis legalisation; they're running in the 2020 Queensland State Election, in an attempt to become local representatives (MPs, or 'Members of Parliament') for the state of Queensland; its highest political office. These are names you should be looking out for on your ballot box… if you want your Labor government to listen!
The Queensland Greens are perhaps some of the strongest progressive political advocates in the state's parliamentary politics; not to mention, one of the more reliably grassroots 'Greens' chapters, across the nation. Unlike the state Greens in Victoria and New South Wales, they have excellent campaigning, and a near-perfect policy record in government.
Candidates and members from The Queensland Greens consistently fight hard to spur meaningful changes, both inside and outside the halls of parliament. It's simply no different when it comes to legal cannabis. As a party, the Queensland Greens are echoing the state Productivity Commission's findings; calling for regulated, legal cannabis, and for drug use to be decriminalised across the state.
Incumbent for Maiwar
Elected in 2017
Michael is a local MP that is doing things differently. He is the first (and thus far, only) Greens member to be elected as a Queensland MP. In his first term, he unapologetically brought drug decriminalisation and cannabis legalisation into the conversation for the first time in Queensland Parliament… ever.
It's important that Michael is returned for a second term, for him and his team to remain resourced. We want to see continued proactive community organising occurring in the district of Maiwar. With leadership that listens and supports such efforts, we could make remarkable things happen.
Maiwar consists of the suburbs of Mount Coot-tha, Bardon, Auchenflower, Toowong, Taringa, Indooroopilly, St Lucia and Fig Tree Pocket.
Suite 1, 49 Station Road
Discussing Drug Decriminalisation With QLD Greens MP Michael Berkman | Friendly Aussie Podcast – Episode 13
Candidate for South Brisbane
The Greens now only need a few hundred votes to win in the electorate of South Brisbane – your vote could make all the difference in a new parliament.
The electorate of South Brisbane encompasses suburbs in Brisbane's inner-south; stretching from East Brisbane to West End, and south to Annerley. Parts of Greenslopes and Coorparoo are also located in the electorate.
20 Hockings Street
WEST END, QLD
Queenslanders suffer from the harshest cannabis laws in Australia. They also experience the highest number of cannabis prosecutions in the country; over 20,000 cannabis offences are handed out in Queensland each year. That's 5000 more than New South Wales, and twice the number of prosecutions, in contrast to Victoria… both of which are more populated states.
To combat the decades-long discrimination against cannabis users, activists from the MCUA and HEMP have joined to form Legalise Cannabis Queensland; supporting the amazing candidates campaigning to legalise cannabis in Queensland. An executive committee was formed, and the organisation successfully acquired 605 members to register as a political party in the upcoming QLD election.
The Queensland Productivity Commission estimated that if the state decriminalised cannabis and MDMA, there would be a net benefit of $850 million dollarsannually to the Queensland economy. Legalisation of cannabis and MDMA would yield greater benefits, still; around $1.2 billion, annually.
Australia: Queensland's Productivity Commission Report Says legalise cannabis & MDMA
It's not a secret, anymore: the legalisation of cannabis in Queensland will save billions of dollars over the course of decades, and reduce the need to build more prisons.
Legalise Cannabis Queensland believes that cannabis should be free to grow, process and share, without a license. Reform should be done at the state level to regulate the sale of cannabis products; with an effective licensing scheme for traders, ensuring compliance with quality control/human consumption safety standards.
The LCQ currently have candidates running in 18 electorates: Inala, Southern Downs, Redlands, Everton, Ipswich, Gaven, Mermaid Beach, Bundaberg, Rockhampton, Mount Ommaney, Nanango, Whitsunday, Burleigh, Mackay, Mansfield, McConnel, West Ipswich and Maryborough.
Be sure to preference your local LCQ candidate, if you live in one of these electorates!
contact@legalisecannabisqld.org.au
Candidate for Mermaid Beach
Long-time medicinal cannabis advocate Deb Lynch plans to set things straight in Queensland.
Ms Lynch understands the issue of cannabis inside out. As the current president of the Medicinal Cannabis Users Association of Australia (MCUA), she vocally campaigns for the rights of patients, who can often find themselves on the wrong side of the law just for seeking relief.
Deb also used to be a part of the Canna Nanna's: a group of grandmothers who toured the east coast of Australia, conducting workshops that outlined the plant's many medicinal and recreational uses.
Yes, that's right. Our very own Joe LaGrasso from the FAB Team is now officially running for Queensland State Parliament, joining forces with other proud cannabis advocates under the banner of Legalise Cannabis Queensland.
Joe is the LCQ candidate for the electorate of Miller; consisting of the inner-southwest suburbs of Brisbane. Miller covers the suburbs of Chelmer, Graceville, Sherwood, Tennyson, Yeerongpilly, Rocklea, Yeronga, Fairfield, Annerley, Tarragindi and Moorooka.
Josip is an industrious young fellow. As a web developer, educator, and online marketer by trade, Joe takes joy in building things; bringing the passions of his community to life.
One of Josip's true passions in life is cannabis. As a matter of fact, he has recently obtained a medicinal prescription for cannabis.
He firmly believes that 'the whole plant' ought to be brought into regulated public access for adults 18 and over. Our government should institute a legal framework to create the space for an efficient, open and diverse cannabis industry to emerge in Australia – for both recreational and medicinal purposes.
Joe is convinced that such a framework – if it were to adopt key lessons from the experiences of other legal models across the world – would eventually provide massive returns to the Australian economy.
Joe's passion has made itself manifest in the online cannabis space. He is the founder of 'Friendly Aussie Buds' (or FAB); a publication with a mission to inform, entertain and support the Australian cannabis community through prohibition and into legalisation.
For over two years, Josip has worked with a small team to deliver high-quality cannabis-related content to the web. Joe co-hosts 'The Friendly Aussie Podcast', interviewing people of interest in the 'cannabis space' and beyond.
FAB's 'FCK PGR' campaign has educated hundreds of thousands of Australians about the harmful impacts of black-market cannabis infused with toxic plant growth hormones. FAB's articles and branding have shone a new light on the phenomenon, in clearly demonstrating to regular folks how they can identify PGR from a cursory glance.
FAB's steadfast focus on education, harm minimisation and drug reform/cannabis legalisation advocacy has already given Joe many opportunities to cultivate connections through the cannabis plant. Running to represent at the state level is the next step in deepening and expanding those connections.
Josip invites the people of his electorate to imagine a future where Queensland adults are free to 'get high', or simply use cannabis; no matter their social or economic background… and without some fancy prescription. Better yet, you should be permitted to grow a supply of your own!
The vibrant and diverse Aussie cannabis community is still unfairly stigmatised; relegated to the fringes of society, rather than receiving the acknowledgement we deserve. In response, Joe wants to bring the argument for legalisation to the mainstream. With the help of the voices, contributions and votes of regular Queenslanders, we can see institutions flip their script overnight.
Joe argues that not only is legalising cannabis just plain 'common sense'; safe production and distribution of cannabis for both medicinal and recreational consumers is a human right.
Beginning on the state level, cannabis legalisation in Australia has the potential to establish our nation as a global leader in bud quality and yield, as well as in fields of research and development geared towards innovative new cannabis and hemp products. Right now, however, we are only falling further behind the rest of the world, under the restrictive TGA licensing and scheduling scheme.
Our communities must take bold steps forward to remain prosperous during this turbulent moment in time. Josip knows this, and proposes cannabis as part of the potential solution.
Joe is absolutely honoured to be leading the LCQ ticket for cannabis advocates across his own electorate! If you live in the electorate of Miller, be sure to VOTE 1 JOSIP – we may even see you at the polling booth!
Candidate for Ipswich
Shelly Morton is all about putting the needs of Ipswich first.
She will be running in the electorate to call for structural reform to the existing legal framework, which includes cannabis legalisation.
Shelly is a mum and business woman, who spends her days helping other women to stand up against the stigma of using cannabis. She supports and encourages the use of cannabis in contexts of period pain, chronic ills, to assist with one's mental health, or for social reasons.
Shelly also has bipolar and schizophrenia. As a legitimate medicinal user of cannabis, Shelly has faced countless boundaries to legal access, and has yet to be accepted into the medicinal cannabis scheme. Shelly is running for all legal adults to gain the right to access cannabis – a life-changing herb – whether medicinally or recreationally.
Shelly is a core member of the 'Her Highness'online community and support group, with over 10 000 women from across Australia as members. Her Highness won 'The Peoples Choice Award' in the 2020 Cannabis Industry Awards.
If you live in the electorate of South Brisbane, you could always vote for John Jiggens!
John is a seasoned cannabis historian, who has written several books on the origin of contemporary cannabis laws. He was also a HEMP candidate for the Senate in 2019. Now, he's running for local MP of South Brisbane.
"Queensland spends $500 million annually on the failed policy of the war on drugs. Prisons are overflowing, and are operating at 130% of capacity. The state outlays $1 billion dollars annually on prisons, and is faced with building another two new prisons to house an anticipated four thousand extra prisoners over the next five years. The expenditure needed for these prisons is estimated to be $3.6 billion dollars – a scandalous waste!
– Dr. John Jiggens
Candidate for Bulimba
If Finn were to become the representative for the seat of Bulimba, he is on record: he would set forward a bill to legalise cannabis across the state on the first sitting of the new parliament.
He may be a controversial name in some circles (thanks to his online social presence), but he's also a man for the job; an independently-minded populist figurehead, who would not take 'no' for an answer.
Finn Armstrong-Schmakeit on Legalising Cannabis in QLD | Friendly Aussie Podcast - Episode 21
Ian is in favour of legalising cannabis for medicinal and recreational use in Queensland. His mission as a progressive Independent candidate is to represent all residents in the Redcliffe electorate.
Edward is running as an independent candidate for the ballot; however, he belongs to the Australian Progressives; he sits on the National Executive, leading the state branch as Interim President.
He's committed to pushing for evidence-based policy reforms that allow for cannabis to be legalised.
Tim is passionate about his electorate, and will fight hard for medicinal and recreational cannabis users to see the plant legalised.
"Politicians need to get off their backsides and serve the people."
Is there anyone that we missed?
If there is a pro-cannabis politician you know of that is running in the QLD state election, but is not on this list… let us know down in the comments.
We'll add them!
Just follow this very simple 'who to vote last' card, for optimum results.
As part of its response to the Queensland Productivity Commissions' inquiry into imprisonment and recidivism (QPC Report), the Palaszczuk Government confirmed that it has no intention of altering any drug laws in Queensland.
Incredibly disappointing, as it means that our supposedly left-leaning government of the day has no guts, and our community will have to drag them kicking and screaming to the correct position.
This decision to ignore expert socio-economic advice was also made in spite of the most signed government e-petition of that year relating directly to the legalisation of cannabis for both medicinal and recreational use. Stubborn bastards!
Cannabis Legalisation is QLD's Most Signed Petition in Past Year
If you can't get Queensland Labor to do it… these guys are never going to get there, in a million years.
Not our allies in the fight for legal cannabis, and should be put below the two majors for their terrible, exclusionary rhetoric and policies.
New petition demands cannabis reform in Queensland
Help LEGALISE CANNABIS in Queensland in 2020!
Author: Mitch
Mitch Keys is a young writer from Brisbane, Australia unfolding in a dynamic process of becoming (like everyone else, so don't go thinking he's special or anything). He likes being alive.
AUSPOL
cannabis legalisation
Decriminalise
Legalise
QLDPOL
state election
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brett j
Voting should require a bit more thinking than a single interest. For example Greens may well be more pro marijuana but you also get some really out there unworkable, impractical and downright batshit crazy policies thrown in like a few that promote child sex.
Check it out but pretty sure my comments will get binned as public speach and opinion is also classed as restricted for Greens followers.
Oi! Give Us A Follow, Mate!
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Using iPSC Techniques to Study Genetics, Mechanisms & Treatments of Neurodegenerative Disorders
By Osman Shabir, M.Sc.Reviewed by Michael Greenwood, M.Sc.
Parkinson's Disease (PD)
Huntington's Disease (HD)
Advances in stem cell technology have enabled us to study the mechanism of disease from cells taken directly from patients in vitro, called human induced pluripotent stem cells (hiPSCs).
Cellular models can provide deeper insights into the pathomechanisms of neurodegeneration that are difficult to investigate in vivo.
Other advances in cellular technology now enable researchers to edit the genome of cells using CRISPR-Cas9. This allows us to investigate how specific mutations (patient or de novo) affect the cells, and indeed in animal models. CRISPR-based genetic screens can also be achieved using iPSC derived neurons.
CRISPR/Cas9 system for editing, regulating and targeting genomes. The Cas9 protein uses a gRNA (guide RNA) sequence to cut DNA at a complementary site. Molecular structure - RNA in red, DNA in yellow - Illustration Credit: ibreakstock / Shutterstock
Alzheimer's Disease (AD) is the most common form of dementia and is pathologically characterised by the presence of beta-amyloid plaques and neurofibrillary tangles of hyperphosphorylated tau. Together these contribute to the progressive neurodegeneration leading to cerebral and hippocampal atrophy, contributing to the progressive symptoms of dementia.
Amyloid plaques growing on a neuron - Illustration Credit: Juan Gaertner / Shutterstock
Most cases of AD are sporadic and have complex aetiologies. However, up to 10% of cases are due to genetically inherited mutations to genes that are involved in the production of beta-amyloid, including APP, PSEN1 and PSEN2. Aside from these genes, other risk genes have also been implicated in sporadic AD including APOE4, SORL1, and SMI-1. Other factors include the same risk factors for cardiovascular disease such as hypertension, atherosclerosis, and diabetes.
Patient-iPSC derived neurons have revealed many different mechanisms, depending on what the causative factor was in the patients. For example, PSEN1(P117R) mutations revealed neurons that were more susceptible to inflammation than controls. Furthermore, cells carrying mutations to PSEN1 were able to induce the hyperphosphorylation of tau. Other APP mutations including the V717 can also elevate levels of phosphorylated tau in neurons. The N1411 mutation in PSEN2 not only increased amyloid-beta (42) production, but also caused a decrease in action potentials. Treating patient-iPSC-neurons with β-/γ-secretase (PSEN1/2) inhibitors such as BSI-IV or compound E, has been shown to reduce beta-amyloid production, in particular the toxic 42-length form. Furthermore, treating cells derived from sporadic patients using β-secretase inhibitors βSi-II and OM99-2 also could reduce AD-phenotypes such as tau-phosphorylation, but not γ-secretase inhibitors.
Patient-iPSC derived neurons from sporadic AD cases with APOE4 alleles revealed high levels of phosphorylated-tau, higher levels of beta-amyloid production, and GABAergic neuronal degeneration. Thus, the mechanisms of sporadic AD are similar to familial AD. Furthermore, using an APOE4 structural corrector to mimic other protective forms of APOE, using PH002, AD phenotypes were reduced. These studies show not only the powerful application of using iPSCs to study disease mechanisms from different genetic variants, but also the ability to use those as drug screening factors in the assessment of various therapeutic compounds.
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PD is a common adult-onset neurodegenerative disease affecting 1% of the population over 60. At the centre of the pathology of PD, there is a loss of dopaminergic neurons in the substantia nigra, and is characterised by the presence of Lewy bodies containing aggregates of alpha-synuclein. The loss of these neurons leads to the motor symptoms of PD including tremor, rigidity, and postural instability.
About 10% of all PD cases are due to genetically inherited mutations involved in mitochondrial function and oxidative stress: SNCA, PARK2, PINK1, Parkin, DJ-1, and LRRK2. In most cases, PD is sporadic, though there are many risk factors including SNPs in SNCA, LRRK2, GBA1 and MAPT (tau). Environmental factors also play an important role in PD pathogenesis and include exposure to herbicides, pesticides, and heavy metals.
Most hiPSCs have focused on the genetic variants of PD, much like in AD. The cause of neuronal death has been attributed to mitochondrial dysfunction due to nitrosative and oxidative stress using SNCA(A53T) cells. Mechanistically, it has been shown that alpha-synuclein oligomers selectively induce oxidation of the ATP synthase beta-subunit leading to changes in permeability and subsequent cell death. In such mutations, mitochondria swell in dopaminergic and cortical neurons.
Another gene, LRRK2, is involved in both familial and sporadic PD. The G2091S mutation has been shown to upregulate alpha-synuclein and cause mitochondrial dysfunction in dopaminergic neurons derived from sporadic PD patients. Furthermore, the G2091S mutation of LRRK2 also has been shown to disintegrate the nuclear envelope, something characteristic of ageing. Blocking LRRK2 (by GW50764) has been shown to prevent neuronal death, and thus is a good candidate for drug therapy in PD.
Huntington's Disease (HD) is a rare autosomal dominant progressive neurodegenerative disorder that has a single monogenic cause, a trinucleotide CAG polyglutamine repeat expansion within the huntingtin (HTT) gene. As a consequence, there is a toxic gain of function product that leads to death of GABAergic neurons within the striatum (striatal medium spiny neurons; MSNs). This leads to the motor symptoms of HD, including chorea and dystonia. CAG repeat length is correlated to disease severity, onset, and prognosis. Unlike most other neurodegenerative diseases that have numerous complex aetiologies, risk factors, and modifiers, HD is purely monogenic.
MSNs can be generated from patient derived hiPSCs. However, to induce a HD phenotype, cells often need to be exposed to stressors such as growth factor withdrawal, hydrogen peroxide treatment, or glutamate stimulation. These stressors can then lead to neuronal cell death and aggregation of mutant HTT.
Rodent studies have revealed that motor deficits can be rescued by transplanting human iPSC-derived neural stem cells, but not alter the function of the striatum due to the lack of effective MSN differentiation and the lack of striatal interneurons to support MSNs. Based on this and other observations that glial cells are important in HD pathogenesis, striatal transplantation of glia reduced disease pathology, and improving behavioural outcomes. Furthermore, glial transplantation also slowed disease progression and increased lifespan in rodent models. iPSC-based glial replacement may therefore be an important therapeutic strategy than iPSC-based MSN replacement in the treatment of HD.
Further support for glial-mediated therapy for HD was shown when a TNFa inhibitor, Xpro1595, was added to a co-culture of MSNs and astrocytes from HD-iPSCs. MSN death was reduced, as Xpro1595 reduced iNOS expression in astrocytes, therefore reducing glial mediated toxicity to MSNs. However, other iPSC studies also show that targeting pathogenic mechanisms in MSNs alone can also reduce HD phenotype, such as by activating DNA repair mechanisms (A2AR-PKA pathway to target H2AX phosphorylation) to improve cell viability.
Neurodegenerative diseases have many pathogenic overlaps in terms of oxidative stress, synaptic dysfunction, excitotoxicity, damaged DNA repair, mitochondrial dysfunction, toxic protein aggregates, and glial-support dysfunction. Patient-derived iPSCs from patients with neurodegeneration not only provide a tool for investigating intrinsic developmental and post-mitotic gene and protein expression, but also an excellent and simple drug screening mechanism. Furthermore, using CRISPR-Cas9 to edit faulty genes, or by using other therapeutic strategies outlined, cells can be transplanted back into the host as a stem cell based therapy, which has very promising results.
The development of 3D tissue cultures and organoids may improve our understanding of cell interactions in disease even further, and may provide more representative understanding of pathomechanisms of therapies that match the 3D environment of the brain. These provide an exciting and promising way to enhance iPSC cultures that can represent different regions of brain tissue. In these organoids, co-cultures of different cell types including neurons and glia can be made, and as long as adequate nutrients and oxygen is provided, 3D cultures can last much longer than 2D-cultures, and may be better for studying neurodegenerative processes that take time to form.
Whilst iPSC techniques have vastly improved and increased our knowledge and understanding of intricate cellular and molecular pathomechanisms of neurodegeneration, it is still important to progress such research; especially focusing on therapies, to animal models. Cell based therapy strategies in pre-clinical animal models are still needed to see if they can integrate, differentiation effectively and rescue both pathology and clinical outcomes. This is important as we first need to establish any ill-effects of iPSC transplantation before trialling them in human patients.
Wu et al, 2019. Opportunities and challenges for the use of induced pluripotent stem cells in modelling neurodegenerative disease. Open Biol. 9(1): 180177. https://www.ncbi.nlm.nih.gov/pubmed/30958120
Kampmann, 2017. A CRISPR Approach to Neurodegenerative Diseases. Trends Mol Med. 23(6):483-485. https://www.ncbi.nlm.nih.gov/pubmed/28478951
All Stem Cells Content
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Stem Cell Properties
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Osman Shabir
Osman is a Neuroscience PhD Research Student at the University of Sheffield studying the impact of cardiovascular disease and Alzheimer's disease on neurovascular coupling using pre-clinical models and neuroimaging techniques.
Shabir, Osman. (2019, October 27). Using iPSC Techniques to Study Genetics, Mechanisms & Treatments of Neurodegenerative Disorders. News-Medical. Retrieved on January 19, 2021 from https://www.news-medical.net/life-sciences/Using-iPSC-Techniques-to-Study-Genetics-Mechanisms-Treatments-of-Neurodegenerative-Disorders.aspx.
Shabir, Osman. "Using iPSC Techniques to Study Genetics, Mechanisms & Treatments of Neurodegenerative Disorders". News-Medical. 19 January 2021. <https://www.news-medical.net/life-sciences/Using-iPSC-Techniques-to-Study-Genetics-Mechanisms-Treatments-of-Neurodegenerative-Disorders.aspx>.
Shabir, Osman. "Using iPSC Techniques to Study Genetics, Mechanisms & Treatments of Neurodegenerative Disorders". News-Medical. https://www.news-medical.net/life-sciences/Using-iPSC-Techniques-to-Study-Genetics-Mechanisms-Treatments-of-Neurodegenerative-Disorders.aspx. (accessed January 19, 2021).
Shabir, Osman. 2019. Using iPSC Techniques to Study Genetics, Mechanisms & Treatments of Neurodegenerative Disorders. News-Medical, viewed 19 January 2021, https://www.news-medical.net/life-sciences/Using-iPSC-Techniques-to-Study-Genetics-Mechanisms-Treatments-of-Neurodegenerative-Disorders.aspx.
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Even in this day and age, where websites can dazzle with their fantastic graphics and ever changing content, simple, static websites still have a very important role to play. Infact it is important to expel the myth that the more dynamic a website is means that it will perform well. This is simply not true. Search engines are quite intelligent applications that filter and index relevant information that is returned to people who initiate a search for specific words or phrases. Thus content is key.
Essentially, in terms of a static website, we refer to a website that is written in straight forword HTML (the language used to produce web pages - Hypertext Markup Language). As no database, or content-management facility is provided, the only way to alter the content seen on a web page is to alter the web page itself (of course, we can do that for you if you would like us to maintain your website). It doesn't mean that the webite will just be boring plain text - of course the intention is to develop it in such a way as to reflect the image of your business effectively. It also doesn't mean that it can't be interactive - specialist forms for customers to complete (e.g. insurance proposal forms, enquiry forms, etc.) can also be incorporated.
Sometimes a business just wants to create a company contact website as an alternative method of 'point of contact' for it's existing clients without the wish to actively promote themselves on the World Wide Web. It isn't always easy for customers to contact busineses during normal office hours, thus a company contact website provides an excellent additional service to a business portfolio.
The design and size of a static website can vary considerably - depending upon your requirements. They could be simplistic and informative, or inclusive of a more graphic element. The number of pages could be from the basic 3 page website (introduction page, about us page, company contact page) to literally hundreds of pages - depending upon the products / service / general information pages that are required.
Essentially, the number of pages that you will have in your finalised website will be dependant upon the amount of information you supply us. Unlike many Web Design Companies - we DO NOT charge you by the page (unless you specifically purchase a 3 or 5 page website). We consider all website design contracts as a project, and as such your payment is for time. This means that we will examine your content thoroughly, and organise it in as many pages as required to maximise your websites potential.


For answers to your financing questions, and to find Colorado's best auto refinancing, contact Flatiron Finance, a new and used car refinancing company based in Colorado. Save big by getting a Flatiron Finance auto refinance loan. Please provide us with a detailed message so that we can meet your needs in the most efficient way possible.


Menu navigation at the top of the page?
I just got a new computer and now there's a large menu navigation at the top of my page when I log in. It's an outline of the Board menu. It continues at the bottom of the page as well, with the board squished in the middle. How do I remove this page formatting?
Re: Menu navigation at the top of the page?
Are you talking about the purple bar at the top? I'm not really following. What did the page used to look like? Can you take a screenshot and post it so we can see what you're looking at now?
If it is the purple menu, I don't think you can get rid of it. Same with the light-colored one at the bottom.
No, it wasn't the purple bar. It looked like a blue page with a written outline of what the board included--like a site map menu--that took up half of the viewing page. But I am happy to say that I figured out the problem. My computer or maybe my browser does not think the encryption on this website is verified and so I had to allow unsafe encryption. When I clicked allow, the site menu disappeared and all the boards appeared on the entire page. However, the https at the beginning of the SCBWI address and the little safe lock became crossed out with a red line. Maybe I have a cyber cop with a red pen living inside my computer??? Suggestions?
Happy to hear you got it figured out. Hmm, I know my PC has serious issues with telling me what is or isn't safe. That coupled with my script-block, I end up having to whitelist quite a few things so I can do my regular browsing.
I think if you allow a site permissions, you should be able to add it to a whitelist as well. That way, you don't have this issue again.


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Gosibius texicolens är en mångfotingart som beskrevs av Chamberlin 1938. Gosibius texicolens ingår i släktet Gosibius och familjen stenkrypare. Inga underarter finns listade i Catalogue of Life.

Källor

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Paris :Union Minister of State (IC) for Power and New & Renewable Energy, Shri Raj Kumar Singh led the Indian delegation in the International Energy Agency (IEA) Ministerial, being held in Paris. The Minister emphasised the importance of clean energy and assured achievement of 175GW of renewable target of India while addressing the Plenary Session on Driving the Transitions to Clean Energy.
At the Ministerial, India signed joint work programmes with IEA and other key members of the IEA Family i.e. Brazil, Chile, India, Indonesia and Thailand. The event focusses on energy security, clean energy technology and government-industry dialogue on investment and digitalization, which would provide major opportunities for efficiency gains in the energy sector in the future.
On the side-lines of the IEA Ministerial, the Minister had a delegate level discussion with the French Minister of State for Ecological and Inclusive Transition, Ms. Brune Poirson. Shri Singh also had a very fruitful discussion on various issues of Power and New & Renewable Energy with the US Secretary of Energy, Mr. James Richard Perry.


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Home » Columns » Emissary » OHIRI: Lion of Harvard
Posted inEmissary
OHIRI: Lion of Harvard
By Emeka Obasi
Visit Havard University,Boston. You will see Ohiri Field Stadium named after Chris Ludger Ohiri, the man who sent four goalkeepers to hospital as a freshman in 1960 and was All Time Best for 50 years until another Nigerian, Andre Akpan, equaled the feat in 2010.
Ohiri's Triple Jump record lasted for 40 years from 1965 until Samyr Laire came in 2005. The Lion was boxing champion, Decathlon champion and arrived the United States from Port Harcourt where he had won Nigeria's soccer Challenge Cup in 1958 with Red Devils.
As a fresh man at Harvard, he stunned the combined Oxford/Cambridge University team in a competition against Harvard/ Yale Universities. Ohiri beat the British captain in Long Jump. The loser was a former captain of the Harvard Track team.
To understand how dreaded the all rounder was, I just have to quote some of the people who were close to him. Testimonies came from team mates, room mates and Harvard officials.
"As a fresh student, he knocked four keepers out, one was unconscious. In his first match, his shot took the keeper to the hospital for X-Ray. He was far ahead of anyone else around." This came from David Straus, Ohiri's room mate in Eliot House.
Seamus Malin, a team mate said : " Chris was hitting rockets, breaking goal posts and knocking goalkeepers out." Another team mate, Stephen Sewall added: "Unlike most of us, he was comfortable in public. He was an angel. And a lion on the soccer field."
Coach Bruce Munro described Ohiri as "probably the greatest soccer player in the US. It was like a man playing with boys. No one could touch him."
Athletics Director, John Reardon, said: "He was not in the usual form of recruited athlete. But he arrived here and he could kick a soccer ball like you can't believe. He scored a ton of goals, and you would not like to be on the other side of the ball coming at you."
Ohiri's buddy, John Thorndike, summed it all up: "He could have played on any team in the world." All his years with the Harvard soccer team, Crimson, the star was the leading Ivy League scorer with 47 goals. Akpan achieved same in November 2010.
The journey to America was ignited in 1959 when David Henry, Director of Admissions, Harvard visited Nigeria. At the time there was only one University in Nigeria, the University College, Ibadan which was just a campus of the University of London.
Stephen Awokoya, a minister in the Education ministry pleaded with Henry to take as many students as he could. Those who got lucky were 24 including Ohiri who a year earlier, had won the Challenge Cup with Port Harcourt Red Devils.
That was when the Pitakwa All Stars boasted of players like Albert Onyeanwuna, Elkanah Onyeali, John Onyeador, David Okoroji, Ray Ohaeri, Francis Uwalaka and Walter Okala.
ALSO READ: Killing of 'Gana' by military: repentant youths felt betrayed ― Ortom
Ohiri was in the Green Eagles team that fought for a slot at the Roma '60 Olympics and had scored two goals in the qualifiers but Harvard was a bigger dream. He was strong enough combining sports and academics and earned more than a degree.
Unfortunately, tragedy struck. In 1966, he fell on the Tennis Court of Harvard Business School. Diagnosed of terminal Leukemia, Ohiri knew it was difficult to come out of the ailment. He weighed his options and chose to return to Nigeria.
The Harvard star had worked at the United Nations [UN] and International Business Machines [IBM]. He also found a wife in Shirley. Both embarked on the journey back to Africa. Ohiri was just 26.
The year 1966 was full of crises in Nigeria. The military struck on January 15. President Nnamdi Azikiwe, who played football and was also an outstanding athlete at Howard University escaped, death. Prime Minister Abubakar Tafawa Balewa, was not as lucky.
On July 29, 1966 there was a counter coup. Head of State, Gen. Johnson Aguiyi Ironsi, was assassinated. What followed was genocide. There was no government in the country. Lt. col Yakubu Gowon assumed office ahead of some of his seniors. Lt. col Emeka Ojukwu would have none of it.
Ohiri dared death. He had cancer already. Accompanied by his wife, he landed in Lagos. At that time many Igbo lives were in danger. The military authorities detained the returnee. Shirley probably had not seen soldiers carrying guns around in the United States.
Some accounts say Ohiri died in detention. However, he managed to get out of confinement and made it to the Eastern Region. On November 7, 1966, the man died. Shirley could not bear it. She rushed back to America and has not made contact with Ohir's friends ever since.
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Square tablecloths are usually used as an overlay to cover a floor-length round cloth, to offer two colors for visual display. They can also be used by themselves for a picnic theme. A 90″x90″ tablecloth works best with a 72″ round table.


Brussels: Bomb Alert Near EU Headquarters. The building was closed to the empty and sides of the road, for the bomb was reported in a company affiliated with EU headquarters in Brussels.
According to the report published in the Washington Post, the company mentioned above is directly linked to EU headquarters, which is very close to the headquarters.
He said that the police closed the streets' roads on the side of the company and started searching for explosives.
He further said that 'All roads on the sides including the company were opened for partially after the discovery'.
According to officials, the company was using the Consultant Office for the European Union Commission, but the company was avoided to mention its name.


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AHD, Inc. brings to bear on the complexities of housing development working relationships with many architects, lawyers, lenders, equity syndicators and contractors experienced in the specialized field of affordable housing.


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[ January 20, 2020 ] Soleimani's Only Public Interview, Ignored by Western MSM COMMENTARY
[ January 20, 2020 ] Behind the Ukrainian Plane Crash in Iran GOVERNMENT
[ January 19, 2020 ] How Trump Rebelled Against The Generals COMMENTARY
[ January 19, 2020 ] Tom Luongo & Alexander Mercouris Discuss Putin's Constitutional Changes – Ejecting the West & IMF Influence COMMENTARY
[ January 19, 2020 ] Are France's Unions Even TRYING to Win the General Strike? COMMENTARY
HomeCOMMENTARYHungarian Leader: Europeans Purposely Being Replaced With Muslims as Soros Profits
Hungarian Leader: Europeans Purposely Being Replaced With Muslims as Soros Profits
June 21, 2018 Pam Barker COMMENTARY, GOVERNMENT, Tyranny 0
SELWYN DUKE
Follow the money and the ideology. That was the message of Hungarian Prime Minister Viktor Orbán (shown) in a recent interview, as he stated that Europe's population was purposely being replaced by venal ideologists — such as billionaire George Soros — who hope to profit from the continent's "ruination." Moreover, he warned that another "high tide" of mass Muslim migration was nigh.
As Breitbart reports:
In a Kossuth Radio discussion on the growing flood of illegal migrants into Balkan countries just outside the European Union — Bosnia has seen arrivals surge by 600 to 700 per cent in recent months — Prime Minister Orbán warned Europe was "seeing signs of a new migration wave, of a rising tide following a low tide; it's rising now, and this poses a challenge."
"We've managed to ensure that now every migrant knows that they shouldn't follow the path marked by the signpost pointing to Hungary," he said, referring to the robust border wall he built at the height of the migrant crisis in 2015, and the anti-illegal immigration 'Stop Soros' legislative package currently passing through the Hungarian parliament.
Tens of thousands of migrants are simply rerouting around Hungary to reach the generous welfare states of Western and Northern Europe, however — with the new Orbán-aligned populist coalition in Austria warning that it may seal its southern border with Slovenia as a result. Bosnia, in turn, warns that they will respond by sealing their southern borders with Serbia and Montenegro, to forestall a situation where migrants travelling north through their territory en route to Austria become bottled up after their path is blocked.
The warning of an impending migrant wave accords with a prediction made by Dr. Mudar Zahran, a leader of the Jordanian Opposition Coalition currently living as an asylee in the United Kingdom. Zahran stated in a 2015 interview that the wave of migration at that time was "only the beginning. We are looking at at least … another 20 to 30 million Muslim/Arab migrants during the next 3 to 5 years," he said. "This is a big issue; this is going to change Europe's culture."
This continual influx of foreigners is unsurprising not because of current Mideast affairs; in reality, the world is the safest it has ever been, and Third World strife is nothing new. The real problem is that if you incentivize something, you get more of it. The carrot? Would-be migrants know that sneaking into Europe likely means they'll be granted asylum and given handouts. Send the opposite message — that you'll be turned away or deported regardless, and, thus, illegal migration is fruitless — and they'll stop coming.
Zahran would agree, too. While a practicing Muslim, he nonetheless characterized the migration as "the soft Islamic conquest of the West" and warned that the so-called refugees should be kept out of Europe.
Ironically, much of Europe's history involved defensive warfare (e.g., the Crusades) to do just that: keep Muslims out. As I wrote in 2015, "Note that Christianity was the dominant religion in the Mideast and North Africa until Muslim armies seized the territory after Islam's birth in 622 A.D.; Muslims also occupied Spain for 650 years, once came within 125 miles of Paris, and twice reached the gates of Vienna."
No one has to tell this to Orbán. Islamic domination is fresher in the Hungarians' memory because their nation was occupied by the Ottoman Empire — the "last great caliphate" (Muslim realm) — for 150 years, until 1699.
As for Soros, his being Hungarian-born hasn't stopped Orbán from becoming his greatest rival. As the Daily Mail reported about the prime minister's radio interview:
In response to press reports that Soros' organisations are in every Balkam [sic] country,
Orbán declared: "It's worth fighting against a force that is stronger than us — against a force like George Soros and his army.
"We've played a role in this network being exposed, as we brought it out into the open, and now they have to openly state their goals. They want immigration.
"The replacement of populations and peoples is under way in Europe, partly because speculators like George Soros can make large financial profits."
One way in which Soros is profiting from Europe's demographic destruction was reported last year by the Capital Research Center, which wrote that the billionaire border buster had "entered into a partnership with credit card giant MasterCard Inc. to create something called Humanity Ventures," a for-profit organization. "'Humanity Ventures is intended to be profitable so as to stimulate involvement from other businesspeople,' Soros and MasterCard said in a joint press release," the think tank related.
Sadly, most today are so blinded by talk of "diversity" — something only foisted on Western countries (wealthy Japan has a declining population, but no one says it needs to be more "diverse") — that people don't see the big picture. To wit: What would the reaction be if some remote Amazonian tribe were being overrun by outsiders? What often is the reaction to the Chinese's domination of Tibet? "This is cultural and demographic genocide!" anthropologists may say. And when the same thing happens to a Western nation?
Then it's called "diversity" — which, dontcha' know, strengthens us.
Speaking of which, Orbán said there also was an ideological motivation behind Europe's "ruination." This was well reflected in Swedish multiculturalist and Social Democrat politician Mona Sahlin (pictured), who actually said in 2001 that "the Swedes must be integrated into the new Sweden; the old Sweden is never coming back." Unfortunately, she's probably correct, which means another culture will be lost to the world. Does anybody care?
As a point of interest, "diversity" comes from the Old French word diversité, which, among other things, could mean "wickedness" and "perversity." But, hey, we know it's all positive today.
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cultural genocide
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Dr. Mudar Zahran
Humanity Ventures
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George Soros: The Man Behind the Mayhem [Video]
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Behind the Ukrainian Plane Crash in Iran
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Tom Luongo & Alexander Mercouris Discuss Putin's Constitutional Changes – Ejecting the West & IMF Influence
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Co-opting Nationalism: The Case of Italy & Salvini
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The Children's and Young Adult Bloggers' Literary Awards (CYBILS) nominations are now open. Readers may nominate their favorite children's books and book apps for the 2014 CYBILS. To be eligible, books must be published between Oct. 16, 2013 and Oct. 15, 2014. Click for more information on how to nominate books.


By Corriveau et al. (2014).
Maybe I'm paranoid, but it would seem that the agenda here is to demonstrate that kids raised in religious homes are superstitious, and apt to believe fantasy. Upon closer inspection, the paper has a few devastating flaws, and really represents bad science.
Consider the set up. The authors have 66 total individuals (5-6 year old female students), broken across four groups (so at best, you'd have 16 kids in each group). With such small numbers, I'm not confident that they can really separate out confounding factors (is a kid who is a "non-churchgoer," but attends parochial school more or less "religious" than a "churchgoer" who attends public school? And can any analysis really tell you that with these sample numbers? There are liars, damn liars, and statisticians. You can make almost anything "significant"…I know from experience).
But, even if we grant them all of that, the questions were loaded and represented repeated measures. They begin with, "Now I'm going to tell you some stories about some people you've never heard of. Some of them are real, and some of them are pretend. After I finish the story, I'm going to ask you to put the picture in the 'real' or the 'pretend' box, and then I'm going to ask you why you decided to put the picture there." But what story did they tell?
This is Joseph. Joseph was sent to a mean king in a land far away. However, God sent Joseph many dreams warning about terrible storms, and Joseph used those dreams to tell the king how to protect his kingdom from the storms. The king was so amazed by Joseph and they became friends.
This is Joseph. Joseph was sent to a mean king in a land far away where there were terrible storms. Joseph used his magical powers to see into the future, and told the king how to protect his kingdom from the storms. The king was so amazed by Joseph and they became friends.
Joseph is a well-known biblical character, not someone a 5-6 year old has never heard of. So, the name Joseph is going to instill trust in the story for those who have any religious background. The researchers should've said "This is Charlie. He went fishing…," etc. Worse, they use the same character in three consecutive stories (in their appendix they detail that they did this for the other stories as well). If the first story was one a religious kid would trust because it involves a known biblical character (Joseph) and God's miraculous work, that will affect subsequent stories about Joseph. You've tainted the child's perception of who Joseph is, and what kinds of things can happen to him.
Again, an honest way of doing this research would've been to offer a biblical story (of Joseph), then a similar story using non-biblical themes and characters, etc.
Unsurprisingly, churchgoer kids failed to identify fiction as fiction (false positives) about 1/3 of the time. Again, those "fictional" stories involved the same basic story line (same names and events), but removed God. So, this is an expected result.
Come on! If John waves his stick and the mountains part, that's magic, even if the sentence doesn't call his stick "magic." Again, the stories still resonated with biblical stories kids would trust. John is a biblical character involved in miraculous events. As is Moses. The researchers jumbled names and events, but it would clearly taint children's impressions of what is possible. Their findings?
The abstract gives the impression that kids raised with religion cannot discriminate between reality and fiction. But, the findings actually show that kids raised in secular settings think anything and everything that violates naturalism is fiction (i.e., no miracles are possible). The religious kids perform well in making distinctions between reality and fiction except for one aspect of the experiment, in which the authors bias the methods by introducing repeated (but modified) stories with biblical characters and events.
I don't think I need to say any more about what's really at play here.
So, we have a situation where 5-6 year old Christian girls are made to look like gullible fools for being unable to tell the difference between Bible stories of people named Joseph, and fairy stories of people named Joseph.
Lesson learned: Our Loving Masters really do have a moral stature lower than cockroaches.