text:
Mutational switch of an IL-6 response to an interferon-γ-like response
Ana P. Costa-Pereira, Silvia Tininini, Birgit Strobl, Tonino Alonzi, Joerg F. Schlaak, Hayaatun Is'harc, Ida Gesualdo, Sally J. Newman, Ian M. Kerr, and Valeria Poli
PNAS June 11, 2002 99 (12) 8043-8047; https://doi.org/10.1073/pnas.122236099
Ana P. Costa-Pereira
Silvia Tininini
Birgit Strobl
Tonino Alonzi
Joerg F. Schlaak
Hayaatun Is'harc
Ida Gesualdo
Sally J. Newman
Ian M. Kerr
Valeria Poli
Communicated by George R. Stark, Cleveland Clinic Foundation, Cleveland, OH (received for review February 27, 2002)
Signaling through Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) is central to the responses to the majority of cytokines and some growth factors, including the interferons (IFNs) and the IL-6 family of cytokines. The biological responses to stimulation through the widely distributed IL-6 and IFN-γ receptors are, however, completely different. Remarkably, it is shown here that, in mouse embryo fibroblasts lacking STAT3, IL-6 mediates an IFN-γ-like response including prolonged activation of STAT1, the induction of multiple IFN-γ-inducible genes, the expression of class II MHC antigens, and an antiviral state. Normal cells exposed to IL-6 thus require a STAT3-dependent function(s) to down-regulate STAT1 activity and prevent an IFN-γ-like response. The data encourage the view that the very disparate IFN-γ and IL-6 JAK/receptor complexes mediate a common set of generic or "core" signals which are subject to STAT3-dependent modulation to provide IL-6 specificity. The switching of one cytokine response to one closely mimicking another as a result of the loss of a single signaling component has profound implications, for example, for the interpretation of the phenotypes of knockout mice and for the clinical use of inhibitors of signaling.
IL-6 and IFN-γ activate essential Janus kinases/signal transducers and activators of transcription (JAKs/STATs) and additional signals through distinct type I and type II cytokine receptors (reviewed in refs. 1–3). For IL-6, signaling occurs through dimerization of the common gp130 signal transduction subunit of the IL-6 family of cytokine receptors. In response to ligand, JAK1, JAK2, Tyk2, STAT1, and STAT3 are all activated; the JAKs are activated through the conserved membrane-proximal binding domain, and the STATs are activated through four more distal receptor tyrosine motifs (2–4). JAK1 and STAT3 play major roles in the response (4, 5). For IFN-γ, signaling occurs through the IFN-γ receptor subunits 1 and 2 (IFNGR1 and -2) and characteristically triggers prolonged STAT1 activation. The internal membrane proximal JAK1- and JAK2-binding domains of IFNGR1 and -2 and the distal Y440 STAT1 recruitment motif of IFNGR1 are essential for activity (reviewed in ref. 6). In experiments to determine the interchangeability of signaling components, minimal chimeric receptors comprising the external domain of the erythropoietin (Epo) receptor and the transmembrane, JAK-binding domain and Y905 motif of the gp130 signal transduction receptor subunit of the IL-6 receptor, were shown to mediate an IFN-γ-like response in both wild-type and IFN-γ receptor− cells (7). In parallel, STAT3− mouse embryo fibroblasts (MEFs) were developed to examine the role of STAT3 in signaling in response to different cytokines (8). The observation of prolonged STAT1 activation and the induction of STAT1-dependent genes by IL-6 in the absence of STAT3 (S.T. and B.S., unpublished work) prompted a more detailed comparison with the IFN-γ response. Here, we show that in the absence of STAT3, an IFN-γ-like response to IL-6 is observed.
Cell Lines and Culture.
STAT3 floxed/floxed (wild-type) MEFs were derived from individual 14-day-old STAT3 floxed/floxed embryos and grown in DMEM supplemented with 10% (vol/vol) heat-inactivated FCS/2 mM L-glutamine/50 units/ml penicillin/50 μg/ml streptomycin (GIBCO/BRL) and immortalized according to Todaro and Green (9). For the STAT3− (deleted/deleted, Δ/Δ) MEFs, to delete the floxed STAT3 alleles, the floxed/floxed MEFs were infected with a recombinant adenovirus expressing the Cre recombinase (10). Individual clones were isolated from the infected pool by limiting dilution and were genotyped by PCR (8). Genotypes were confirmed by Southern and Western blot analyses (8). For complemented cells, the STAT3− MEFs were stably transfected with pZeo-STAT3 and selected with zeocin (400 μg/ml, Invitrogen). Individual clones, isolated by limiting dilution, were characterized for comparable STAT3 expression to wild-type MEFs.
Antibodies and Cytokines.
Antibodies against STAT1 and STAT3 were obtained from Santa Cruz Biotechnology; phycoerythrin (PE)-conjugated anti-mouse-I-A/I-E antibody, the neutralizing antibody against IFN-γ, and the isotypic control antibody were obtained from PharMingen. Phosphorylated tyrosine residues were detected by using a mix of PY-20 (Transduction Laboratories, Lexington, KY) and 4G10 (Upstate Biotechnology, Lake Placid, NY) antibodies. Human IL-6 and soluble IL-6 receptor were obtained from R & D Systems. Highly purified, recombinant murine IFN-γ (1–2 × 107 units/mg) was the generous gift of G. Adolf (Ernst-Boehringer Institut für Arzneimittelforschung, Vienna, Austria).
Cell Lysis, Immunoprecipitations, Western Blotting, and Electrophoretic Mobility-Shift Assays (EMSAs).
Cell lysis was performed on ice in 50 mM Tris, pH 8.0/0.5% (vol/vol) Nonidet P-40/10% (vol/vol) glycerol/150 mM NaCl/1 mM DTT/0.1 mM EDTA/0.2 mM sodium orthovanadate/25 mM sodium fluoride/0.5 mM phenylmethylsulfonyl fluoride/3 μg/ml aprotinin/1 μg/ml leupeptin. Cell debris was removed by centrifugation and whole-cell extracts used for EMSA or immunoprecipitations, as described (11).
Expression Profiling: Macroarray Analysis.
RNA extraction and preparation of 33P-labeled cDNAs and the preparation of the macroarrays representing 70 known murine IFN-γ-inducible genes, hybridization of the radioactive cDNAs, and scanning of the arrays were carried out as described (7, 12). Detailed protocols are available from the Kerr lab on request.
Fluorescence-Activated Cell Sorting.
Cells treated with medium only, IFN-γ at 1,000 units/ml or human IL-6, 200 ng/ml, and sIL-6R, 250 ng/ml, for 72 h were removed from the plate, washed in ice-cold medium, and incubated with phycoerythrin-conjugated anti-mouse-I-A/I-E or control antibody for 45 min on ice. Cells were washed two times with ice-cold PBS/1% (vol/vol) FCS/5 mM EDTA, once with PBS, fixed in 1% (vol/vol) p-formaldehyde, and analyzed on a Becton Dickinson fluorescence-activated cell sorter (FACS).
Antiviral Assays.
Cells seeded into 96-well plates at 2 × 104 cells per well were incubated overnight at 37°C, neutralizing antibodies or isotypic control antibodies (10 μg/ml) were added where indicated, and cells were treated with serial two-fold dilutions of ligand for 18 h. Cells were challenged for 24 h with 0.5 plaque-forming units (pfu)/cell of encephalomyocarditis (EMC) virus, where indicated, fixed, and stained with Giemsa stain for live cells. Requests for materials can be addressed to v.poli{at}dundee.ac.uk or ian.kerr{at}cancer.org.uk.
Prolonged Activation of STAT1 by IL-6 in the Absence of STAT3.
IFN-γ characteristically activates STAT1 and, in certain cell types, STAT3 or -5 (for example, see ref. 13). In MEFs, IFN-γ activates STAT1 and, to a lesser extent, STAT3 (Fig. 1). The absence of STAT3 had no major effect, however, on the induction by IFN-γ of a significant set of known IFN-γ-inducible genes, class II MHC antigens or an antiviral state (Table 1, Figs. 2 and 3). Therefore, the significance of STAT3 activation for the IFN-γ response in these cells remains to be established. For IL-6, however, the presence or absence of STAT3 profoundly affects the kinetics of STAT1 activation. In wild-type MEFs (floxed/floxed, see Materials and Methods), the patterns of activation of STAT1 by IFN-γ and IL-6 are completely different, as they are prolonged in response to IFN-γ but transient in response to IL-6 (Fig. 1). In contrast, in the STAT3− MEFs (Δ/Δ), the activation of STAT1 shows similarly prolonged kinetics in response to either ligand (Fig. 1). It is reasonable to conclude that in wild-type cells there is a STAT3-dependent down-regulation of STAT1 activity. It will be of interest to determine whether this down-regulation is direct or indirect (14) and what are the mechanisms involved. There is no corresponding difference in the extent or kinetics of JAK activation in response to IL-6 in the wild-type vs. the STAT3− cells (data not presented). The inhibition of STAT1 function(s) is unlikely to reflect simple competition between STAT1 and -3 either at or downstream of the receptor; for example, in wild-type cells, STAT3 activation by IL-6 or OSM does not inhibit an IFN-γ-mediated response. Intriguingly, the STAT1 "activated" in response to IL-6 or OSM seems to be defective in mediating a transcriptional response (ref. 15, and H.I., B.S., A.P.C.-P., and I.M.K., unpublished work). The data are in accord with at least two mechanisms for the inhibition: the first governs the transcriptional activity of the "activated" STAT1, and the second governs the kinetics of the activation/deactivation. A role(s) for STAT1/3 heterodimers in either or both of these cannot, of course, be excluded.
IL-6 induces prolonged STAT1-activation in cells lacking STAT3. STAT3 wild-type (floxed/floxed) or STAT3− (Δ/Δ) MEFs were stimulated with 200 ng/ml IL-6 and 250 ng/ml sIL-6R or 1,000 units/ml of IFN-γ for the times indicated. (Upper) STAT1 and STAT3 activation: EMSAs with an hSIE probe (see Materials and Methods). (Lower) Tyrosine phosphorylation: immunoprecipitates for STAT1 or STAT3 were separated by SDS/7.5% PAGE, and Western blot analysis was carried out with anti-phosphotyrosine antibodies. Blots were stripped and sequentially probed for the respective protein. The enhanced signal for STAT1 protein at 8 and 24 h reflects de novo synthesis of STAT1 mRNA (Table 1) and protein. Data are representative of at least three experiments.
Induction of IFN-γ-inducible genes in WT and STAT3− MEFs
IL-6 induces class II MHC antigens in STAT3− but not wild-type MEFs. STAT3 floxed/floxed and STAT3 Δ/Δ MEFs and STAT3 Δ/Δ MEFs stably complemented with STAT3 were incubated with 200 ng/ml IL-6 and 250 ng/ml sIL-6R or 1,000 units/ml of murine IFN-γ for 72 h as indicated. Class II MHC expression was determined by FACS analysis using phycoerythrin-conjugated antibody to class II MHC antigens (see Materials and Methods). Bold lines, antibody to class II MHC antigens; light line peaks, control antibody. The numbers (top right) represent the percentage of cells showing significant induction above controls. Data are representative of at least three experiments.
In STAT3− MEFs, IL-6 induces an antiviral response in the presence or absence of neutralizing antibodies to IFN-γ. STAT 3 Δ/Δ (Upper) or STAT3 floxed/floxed (Lower) MEFs were treated for 18 h at 37°C with serial two-fold dilutions of IL-6 or IFN-γ, as indicated, in the presence of 10 μg/ml of either a neutralizing anti-IFN-γ antibody (anti-IFN-γ) or an isotypic control antibody (C). Cells were infected with EMC virus (0.5 pfu/cell) where indicated and fixed and stained 24 h after infection. Data are representative of at least three experiments.
Induction of IFN-Inducible Genes by IL-6 in the Absence of STAT3.
Consistent with the prolonged STAT1 activation, IL-6 efficiently induces the expression of IFN-γ-inducible genes in STAT3− but not in wild-type MEFs. Wild-type and STAT3− MEFs were stimulated for 3, 6, and 18 h with physiological concentrations of IFN-γ or IL-6 and were subjected to expression profiling by using low-density cDNA arrays representing a selection of predominantly IFN-γ-inducible genes. The 30 most highly IFN-γ-induced genes at 6 and 18 h are listed (Table 1). In wild-type cells, none of these genes was induced in response to IL-6. In contrast, in the STAT3− cells, the same spectrum of genes was induced with similar kinetics in response to the two ligands: of the roughly 70 genes represented on the arrays, all of those induced by IFN-γ also were induced by IL-6 (Table 1). Accordingly, stimulation through the very different IFN-γ and IL-6 receptors results in a remarkably similar induction of a substantial set of IFN-γ-inducible genes in the STAT3− cells. To generate levels of IFN-γ-inducible mRNAs comparable to those observed (Table 1), substantial levels (>10 to 100 units/ml) of IFN-γ would be required. Neither IFN-γ mRNA nor IFN-γ per se were, however, detected by sensitive RNase protection or ELISA assays, respectively, at multiple time points from zero to 72 h of treatment of the STAT3− cells with IL-6. Moreover, treatment of wild-type cells with conditioned medium from the IL-6-treated STAT3− cells failed to induce an antiviral response (data not presented). It is reasonable to conclude that the induction of the IFN-γ-like response through IL-6 does not reflect the secondary production of either type I or type II IFNs.
Induction of Class II MHC Antigens and an Antiviral State by IL-6 in the Absence of STAT3.
The induction of an antiviral state is characteristic of the IFNs, and the induction of class II MHC antigens is characteristic of IFN-γ in particular. Therefore, the ability of IL-6 to induce such responses in the STAT3− cells was investigated. Cell-surface expression of class II MHC antigens was observed with time in the wild-type MEFs in response to IFN-γ but not IL-6 (data for the 72-h time points only are presented in Fig. 2). In the absence of STAT3, comparable levels of expression were observed for IFN-γ and IL-6 (Fig. 2). Similarly, the treatment of wild-type cells with IFN-γ, but not IL-6, provided good protection vs. the cytopathic effects of EMC virus infection (stained cells, Fig. 3 Lower, 'C' rows). In cells lacking STAT3, substantial protection was observed with both ligands (Fig. 3 Upper). In both types of cell, as expected, protection vs. the cytopathic effects of EMC virus through IFN-γ was inhibited by neutralizing antibody to IFN-γ (Fig. 3 Upper and Lower, IFN-γ rows). No such effect of the antibody was observed on the protection provided by IL-6, again excluding any role for IFN-γ in the IL-6 response in the STAT3− cells (Fig. 3 Upper, compare the IFN-γ rows with the IL-6 rows). When stably complemented with STAT3, the STAT3− MEFs (Δ/Δ) show in each of these assays (STAT1 activation, MHC antigen expression, and the induction of an antiviral state), an essentially wild-type phenotype. For example, like the wild-type MEFs and in striking contrast to the STAT3− MEFs, the complemented cells show no induction of class II MHC antigens in response to IL-6 (Fig. 2). Similar results have been obtained with more than one independent clone for both the STAT3− and complemented cells. Initial studies suggest that prolonged activation of STAT1, the induction of class II MHC antigens, and an antiviral state also may be seen in response to oncostatin M in the STAT3− cells.
Activated STAT1 diffuses freely, consistent with random-walk models for movement in both the cytoplasmic and nuclear compartments of the cell (11), and a minimal, completely foreign, chimeric receptor can mediate an IFN-γ-like response (7), data indicative of highly flexible modular signaling. Consistent with this finding, it is shown here that, in the absence of STAT3, an IFN-γ-like response is mediated through the endogenous IL-6 receptor. A priori, this IFN-γ-like response could occur through cross-recruitment or -phosphorylation of IFNGR1. Rigorous exclusion of any such possibility would, of course, require cells doubly negative for STAT3 and IFNGR1. In the work with the chimeric receptors, however, cross-phosphorylation of IFNGR1, although observed in wild-type cells, was not required for the IFN-γ-like response, which was equally potent in IFNGR1− cells (7). Thus, tempting though it might be to invoke a requirement for receptor cross-phosphorylation, it is unlikely to be the case. It is more likely, therefore, that the IFN-γ-like response to IL-6 reflects a high degree of overlap in the signals generated through the IFN-γ and IL-6 receptors per se. IL-6 and IFN-γ are known to activate multiple common pathways in addition to the STATs, including those for Ser-727 phosphorylation of STAT1 (16, 17) and the phosphatidylinositol 3-kinase/Akt, MKK1/ERK1 and –2, and p38 mitogen-activated protein kinase pathways (18–20, reviewed in ref. 21), all of which are, in fact, activated by both ligands in both the wild-type and STAT3− MEFs (data not presented). Consistent with this finding, the activation of STAT1 is essential but not sufficient, for example, for a full IFN-γ antiviral response (22, 23). Accordingly, it is likely that, in the absence of STAT3, the prolonged activation of STAT1 is essential but not sufficient for the IFN-γ-like response to IL-6. All of the pathways necessary for the latter response must, however, be activated through the highly disparate IFN-γ and IL-6 receptors in the STAT3− cells, which, in turn, is in accord with the concept of a generic or "core" set of signals from JAK/receptor complexes with add-on modulation through additional receptor elements. These are combined, presumably, with cell-type specific modulation through variation in cellular background. Core signaling is also suggested by the high degree of overlap in the responses to different growth factors revealed by microarray expression profiling (21, 23–25). It is particularly intriguing that analogous core signaling has been proposed by Ihle and coworkers (26) from an analysis of the responses observed through modified Epo receptors in a variety of transgenic mice. Irrespective of mechanism, however, the data here are of interest per se and confirm the recognized potential for complexity in the interpretation of phenotypes observed in mutants in signaling pathways in knockout mice. Accepting the fundamental role of STAT3 in multiple pathways and that these data are likely only a particular example of what may well prove to be a more general phenomenon, they also emphasize the caution necessary in the proposed use of signaling inhibitors, including those for STAT3, in the clinical treatment of patients (27, 28).
We thank Frank Graham for the adenovirus vector expressing the Cre recombinase and Gunter Adolf and Howard Young for generous gifts of highly purified, recombinant murine IFN-γ and an RNase protection probe for murine IFN-γ, respectively. We also thank Sandra Diebold, Roman Sporri, Oliver Schulz, and Caetano Reis e Sousa for antibodies to murine IFN-γ and positive control samples for the assays of murine IFN-γ mRNA and IFN-γ per se. This work was supported in part by a Wellcome Trust Senior Research Fellowship (to V.P.). T.A. was the recipient of a European Community Marie Curie Postdoctoral Fellowship. J.F.S. received an Alexander Humbolt Foundation Feodor Lynen Grant. Cancer Research UK London Research Institute is composed of the Lincoln's Inn Fields and Clare Hall Laboratories of the former Imperial Cancer Research Fund (ICRF) after the merger of the ICRF with the Cancer Research Campaign in February 2002.
↵† A.P.C.-P., S.T., and B.S. contributed equally to this work.
↵§ Present address: Institute of Animal Breeding and Genetics, Veterinaerplatz 1, A-1210 Vienna, Austria.
↵¶ Present address: Gene Expression Laboratory, Istituto di Ricovero e Cura a Carattere Scientifico Spallanzani, 00149 Rome, Italy.
↵‖ Present address: University of Essen, Gastroenterology and Hepatology, Hufelandstrasse 55, 45122 Essen, Germany.
↵** To whom reprint requests should be addressed. E-mail: ian.kerr{at}cancer.org.uk.
↵‡‡ Present address: DiPartimento di Genetica, Biologia e Biochimica, via Santena 5bis, 10126 Torino, Italy.
JAK,
Janus kinase;
STAT,
signal transducer and activator of transcription;
IFNGR1,
-2, interferon-γ receptor subunit 1, 2;
MEF,
mouse embryo fibroblast
Accepted April 19, 2002.
Stark G R,
Kerr I M,
Williams B R G,
Silverman R H,
Schreiber R D
(1998) Annu Rev Biochem 67:227–264, pmid:9759489.
Hirano T,
Nakajima K,
Hibi M
(1997) Cytokine Growth Factor Rev 8:241–252, pmid:9620640.
Heinrich P C,
Behrmann I,
Muller-Newen G,
Schaper F,
Graeve L
(1998) Biochem J 334:297–314, pmid:9716487.
Stahl N,
Farruggella T J,
Boulton T G,
Zhong Z,
Darnell J E Jr,
Yancopoulos G D
(1995) Science 267:1349–1353, pmid:7871433.
Guschin D,
Rogers N,
Briscoe J,
Witthuhn B,
Watling D,
Horn F,
Pellegrini S,
Yasukawa K,
Heinrich P,
Bach E A,
Aguet M,
(1997) Annu Rev Immunol 15:563–591, pmid:9143700.
Strobl B,
Arulampalam V,
Is'harc H,
Newman S J,
Schlaak J F,
Costa-Pereira A P,
Sheehan K C,
(2001) EMBO J 20:5431–5442, pmid:11574475.
Alonzi T,
Maritano D,
Gorgoni B,
Rizzuto G,
Libert C,
Poli V
(2001) Mol Cell Biol 21:1621–1632, pmid:11238899.
Todaro G J,
Green H
(1963) J Cell Biol 17:299–313, pmid:13985244.
Anton M,
Graham F L
Lillemeier B F,
Koster M,
Kerr I M
Aberger F,
Williams T M,
O'Shaughnessy R F,
Hollaus G,
Frischauf A M
(2001) Genomics 77:50–57, pmid:11543632.
Woldman I,
Varinou L,
Ramsauer K,
Rapp B,
Decker T
(2001) J Biol Chem 276:45722–45728, pmid:11577084.
Diehl S,
Anguita J,
Hoffmeyer A,
Zapton T,
Ihle J N,
Fikrig E,
Rincon M
(2000) Immunity 13:805–815, pmid:11163196.
Mahboubi K,
Pober J S
(2002) J Biol Chem 277:8012–8021, pmid:11777927.
Kovarik P,
Stoiber D,
Eyers P A,
Menghini R,
Neininger A,
Gaestel M,
Cohen P,
(1999) Proc Natl Acad Sci USA 96:13956–13961, pmid:10570180.
Uddin S,
Lekmine F,
Sharma N,
Majchrzak B,
Mayer I,
Young P R,
Bokoch G M,
Fish E N,
Platanias L C
Nguyen H,
Ramana C V,
Bayes J,
Stark G R
Stancato L F,
Yu C R,
Petricoin E F 3rd,
Larner A C
Goh K C,
Haque S J,
Williams B R
Gil M P,
Schreiber R D,
(2002) Trends Immunol 23:96–101, pmid:11929133.
Rogers N C,
Witthuhn B A,
Harpur A G,
Wilks A F,
(1996) EMBO J 15:799–809, pmid:8631301.
Bohn E,
O'Guin A K,
Levine B,
Virgin H W,
(2001) Proc Natl Acad Sci USA 98:6680–6685, pmid:11390995.
Fambrough D,
McClure K,
Kazlauskas A,
Lander E S
(1999) Cell 97:727–741, pmid:10380925.
Han Y,
Ransohoff R M,
Zang H,
Sato K,
Nakajima H,
McKay C,
Ney P A,
Ihle J N
Turkson J,
Jove R
(2000) Oncogene 19:6613–6626, pmid:11426647.
Ryan D,
Kim J S,
Zhang Y,
Chen Z,
Haura E,
Laudano A,
Sebti S,
Hamilton A D,
You are going to email the following Mutational switch of an IL-6 response to an interferon-γ-like response
Ana P. Costa-Pereira, Silvia Tininini, Birgit Strobl, Tonino Alonzi, Joerg F. Schlaak, Hayaatun Is'harc, Ida Gesualdo, Sally J. Newman, Ian M. Kerr, Valeria Poli
Proceedings of the National Academy of Sciences Jun 2002, 99 (12) 8043-8047; DOI: 10.1073/pnas.122236099


So you'd want to play the original NHL94 on PC retroarch and verify where it stores the SRM, then replace that SRM with the Android one.
Yeah, I've done exactly that on both sides.
Shame, I just figured, it's going well, looks like I'm going to get to the final, and now I'm there and wanted to pick up on the TV via the RetroArch PC program.
What do you guys recommend for playing on PC? Is Gens still the one?
Ok, I've tried turning on the "Leave Off" and it exposed the User Records when I continued the game. So what I'm gonna try is bringing the ROM back to the PC to see if it opens up that in-game save as well. It's only gonna be in the ROM right? Obviously there's no other save location for in-game saves than the ROM itself.
The ROM contains no save data. It's "read-only memory".
.srm file contains the playoff and user data.
I don't know. Try some stuff out but this isn't the place to discuss how to do it. It is something to do with ALL of the modded ROMs. If you want to save whatever you're trying to save, play NHL'94 classic. I have no problem saving progress on playoffs in GENS or RA.
Guys, can this discussion please take place on a new forum somewhere? His issue has nothing to do with this ROM, it's up to @tinpanalley to start a new topic.
I'm done. Thanks everyone and apologies. In fact, mods can feel free to remove the posts I've made here.
Oops, had a small error on the playoff brackets. I just fixed it and added the right one.


text:
News World 365
Your Go To Guide For Sports Analytics
NFL kicker's ultimate redemption after 17-year low
1 year ago Antwon Bode
MASON Crosby, who missed four kicks a week ago, connected on a 27-yard field goal as time expired to lift the Green Bay Packers over San Francisco 33-30 in an NFL thriller on Monday (Tuesday AEDT).
Aaron Rodgers completed 25-of-46 passes for 425 yards and two touchdowns to Davante Adams, guiding the Packers on a tying touchdown drive then leading Green Bay on an unlikely march for Crosby's game-winning redemption field goal.
"Awesome game to bounce back," Crosby said.
What a difference a week makes… Crosby had a shocker last week against Detroit, missing five attempts on goal. Picture: GettySource:AP
"I was hoping I would get a lot of chances. I'm broken up about it. It's unreal. That was a gutsy win right there.
"I just went back to my fundamentals and the process. I was rushing last week. It felt so smooth today. What a great win."
REDEMPTION FOR MASON CROSBY.
(via @NFL) pic.twitter.com/5Qcz881uuo
— Bleacher Report (@BleacherReport)
The Packers improved to 3-2 with one drawn while San Francisco fell to 1-5.
Robbie Gould kicked a 46-yard field goal to end the second quarter that gave the 49ers a 24-20 halftime lead.
Crosby answered with a 51-yard field goal but Gould responded from 43 and 44 yards to boost San Francisco's edge to 30-23 with 13:08 to play.
The 49ers stopped Green Bay at the 4-yard line to deny the Packers a touchdown but San Francisco couldn't manage a first down and Green Bay battled back to delight a home crowd at Lambeau Field.
No mistake… Mason Crosby (2) slots the matchwinning field goal. Picture: GettySource:AFP
Rodgers connected with Adams on a 16-yard touchdown pass with 1:55 remaining and Crosby kicked the conversion to equalise.
Green Bay's Kevin King intercepted a C.J. Beathard pass at the Packers' 10-yard line with 67 seconds remaining and Rodgers then drove the Packers 81 yards in 10 plays, the march capped with Crosby's winning field goal.
"He had a rough one last week but we love Mase," Rodgers said.
"The guys have wrapped their arms around him all week.
"We had faith in Mason from everywhere. To get him even closer made that kick almost a certainty."
Green Bay Packers quarterback Aaron Rodgers (12) spearheaded the comeback. Picture: AFPSource:AP
Rodgers, nagged by a left knee injury suffered in the season opener, now enjoys an off week before the Packers face the unbeaten Los Angeles Rams and New England the following week.
"It's a nice win going into the bye week," Rodgers said. "We're going to find out what kind of team we are." San Francisco drove 75 yards in seven plays after the opening kick-off and scored on Matt Breida's 3-yard touchdown run.
The Packers answered just 1:42 later on Ty Montgomery's 2-yard touchdown run with Rodgers connecting on a 60-yard pass to rookie Marquez Valdez-Scantling to set up the score.
C.J. Beathard (3) had a huge game for the San Francisco 49ers. Picture: AFPSource:AFP
Green Bay recovered a fumble on the ensuing kick-off that led to a 29-yard Crosby field goal for a 10-7 Packers lead.
Rodgers connected with Adams on a 9-yard touchdown pass to boost Green Bay's lead but the 49ers answered quickly on Beathard's 67-yard touchdown toss to Marquise Goodwin that pulled San Francisco within 17-14 after a wild first quarter.
Crosby added a 39-yard field goal for the Packers but Goodwin, a 2012 US Olympic long jumper, grabbed a 30-yard touchdown throw from Beathard and the 49ers seized a 21-20 lead with 6:05 remaining in the first half.
Next Sunday foray adds to NFL playoff intrigue
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3 months ago Antwon Bode
How Theresa Caputo's Parents Really Feel About the 'Long Island Medium's Divorce
Facebook CEO seeks $500M for Bay Area affordable housing
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redpajama_set_name: RedPajamaCommonCrawl


text:
MLS is Back: All 26 Teams to Resume Season at ESPN Wide World of Sports Complex Starting July 8
NEW YORK & LAKE BUENA VISTA, Fla. (Wednesday, June 10, 2020) – Major League Soccer today announced the league's plan to restart the 2020 season with all 26 MLS clubs competing in the MLS is Back Tournamentat ESPN Wide World of Sports Complex at Walt Disney World Resort in Florida beginning July 8. The tournament, which will be played without fans in attendance, provides a compelling way for MLS to resume its 25thseason. Group stage matches will count in the MLS regular season standings and the tournament winner will earn a spot in the 2021 Scotiabank Concacaf Champions League.
"We are pleased to team up with Disney to relaunch the 2020 MLS season and get back to playing soccer," said MLS Commissioner Don Garber. "The opportunity to have all 26 clubs in a controlled environment enables us to help protect the health of our players, coaches and staff as we return to play. We also recognize that the death of George Floyd and others has focused our country on issues of racial injustice, inequality and violence against black men and women. Together with our owners, players and staff, the League and its Clubs are deeply committed to creating meaningful and impactful programs to address these issues that have plagued our society for far too long."
Major League Soccer has a longstanding relationship with ESPN Wide World of Sports Complex. The league held its 1998 preseason at the complex, and hosted events for the 1998 and 2019 MLS All-Star Games at the facilities.
"Sports have the power to unify and inspire, particularly during challenging times," said Josh D'Amaro, chairman, Disney Parks, Experiences and Products. "And we're looking forward to bringing this exciting sport back to millions of fans, while prioritizing the health and well-being of the players, coaches and support staff as well as our cast members."
Clubs will begin arriving in Orlando as early as June 24 for preseason training. Clubs that can conduct full team training in their markets pursuant to the league's medical and testing protocols must arrive no later than seven days before their first match.
Similar to a FIFA World Cup format, the tournament will feature a continuous schedule of matches nearly every day, with games beginning at 9 a.m., 8 p.m. and 10:30 p.m. EDT. The vast majority of the matches will be played in the evening. Each team will play three group stage matches, and those results will count in the 2020 MLS regular season standings. After 16 consecutive days of group stage matches, the top two teams from each group along with the four best third-place finishers will move on to the knockout stage. The knockout stage will include a Round-of-16, Quarterfinals, Semifinals, and the Championship match will take place on August 11. Matches tied at the end of regulation in the knock-out phase will proceed directly to a penalty kick shootout. Click HERE for the MLS is Back Tournament Competition Guidelines.
MLS worked with U.S. Soccer, Canada Soccer and Concacaf to institute a one-time change to MLS berths to the annual Scotiabank Concacaf Champions League. The MLS is Back Tournamentwinner will earn a spot in the 2021 Scotiabank Concacaf Champions League, regardless of whether it is a U.S. or Canadian club. The winner would replace the berth previously awarded to the MLS regular season points leader in the conference opposite of the 2020 Supporters' Shield winner.
In addition to matches that count in the regular season standings and the Champions League berth, players will have the opportunity to earn additional bonuses as part of a $1.1 million prize pool.
The substitution limit for the tournament will follow the new protocol set by the IFAB and allow five substitutions per match. In addition, teams may name up to 23 players on each official match day roster. Also, the Professional Referees Organization (PRO) will have access to video review for all games.
For the MLS is Back Tournament, the 26 MLS teams will be drawn into one of six groups during a live draw that will take place tomorrow, Thursday, June 11 at 3:30 p.m. EDT. For the remainder of the 2020 MLS season, Nashville SC will be moved to the Eastern Conference. The Eastern Conference will have three groups, one consisting of six teams and two consisting of four teams each. The Western Conference will have three groups, each consisting of four teams.
As the host club, Orlando City SC will be given the top seed in Group A, which will be the six-team group, and will play in the first match on July 8. The five remaining seeds will consist of the four semifinalists from the 2019 MLS Cup Playoffs – Atlanta United, Los Angeles Football Club, Seattle Sounders FC, Toronto FC – and Real Salt Lake (the team with the next highest points total in the Western Conference from the 2019 season). The seeded teams will be drawn into their respective groups first and then the remaining 20 clubs will be drawn and distributed across the conference-based groups.
In addition, the tournament schedule, national television partner networks, and other important details for the MLS is Back Tournamentwill be provided soon.
Upon completion of the MLS is Back Tournament, MLS plans to continue its regular season with a revised schedule in home markets, followed by the Audi MLS Cup Playoffs and the 25thMLS Cup. The final number of matches and the schedule for the remainder of the 2020 MLS regular season will be announced in the coming weeks.
The MLS medical department and the league's infectious disease experts have developed a comprehensive COVID-19 testing plan which will be implemented for the entire MLS is Back Tournament. An overview of health, safety and medical protocols can be found HERE. In addition, MLS will make a contribution of serology (antibody) tests to Central Florida residents beginning June 18.
June 24: Teams begin arriving in Florida
July 8: MLS is Back Tournamentgroup stage begins
July 25-28: Round-of-16
July 30- Aug. 1: Quarterfinals
August 5-6: Semifinals
August 11: MLS is Back TournamentFinal
MLS IS BACK TOURNAMENT– July 8 – August 11
Number of Matches: 54 (39 group; 15 knockout)
No. of matchdays: 26
Format: Group Stage, followed by Round-of-16, Quarterfinals, Semifinals &
Championship match
Minimum Matches: 3 (per club)
Maximum Matches: 7 (per club)
Media Conference Call with Major League Soccer Commissioner Don Garber: Commissioner Don Garber will be available to the media today following the league's official announcement to restart play with all 26 teams in a tournament at the ESPN Wide World of Sports Complex in Florida. Today's call will begin at 12:30 p.m. ET.
Register in advance and join the video media conference using following link:
https://mlssoccer.zoom.us/webinar/register/WN_I179cSyZRQi6md9G9mHLrQ
Zoom ID: 929 1669 4863
Soundbytes from MLS Commissioner Don Garber, Players and Coaches on this announcement can be found here
MLS is Back TournamentLogo and Assets can be found here
Photos and Video of ESPN Wide World of Sports Complex can be found here
General MLS footage, including players at ESPN Wide World of Sports Complex from 2019 MLS All-Star week, can be found here
For more information about the MLS Return to Play Medical Protocol, click here
MLS Communications will be offering assets and information via the MLS Media Resource Sitethroughout the MLS is Back Tournament.
Due to health and safety regulations, a limited number of media members will be accredited to attend each game. For more information about how to cover the MLS is Back Tournamentin person and to apply for a media credential, please click HERE. Without exception, the deadline to apply for credentials is June 16 at noon ET.
About Major League Soccer
Headquartered in New York City, Major League Soccer – celebrating its 25th Season in 2020 – features 26 clubs throughout the United States and Canada, in addition to future expansion teams in Austin, St. Louis, Sacramento, and Charlotte. For more information about MLS, visit www.MLSsoccer.com.
About ESPN Wide World of Sports Complex
ESPN Wide World of Sports Complex, located at Walt Disney World Resort in Florida, is one of the premier sites for amateur sports in the nation. The complex hosts more than 100 entertainment and sporting events each year and has accommodated 70 different sports featuring athletes from 70 different countries. Designed to provide professional, amateur and youth athletes with experiences synonymous with the names Disney and ESPN, the 220-acre facility features multiple competition venues, including 16 baseball/softball fields, a 9,500-seat ballpark, 18 multi-purpose outdoor fields for soccer, football and field hockey, three indoor venues for basketball, volleyball, cheerleading, dance and other indoor sports, a track & field facility and a cross country course. For more information, visit www.disneysportsnews.com for news releases, photos and videos. Follow us on Twitter at @ESPNWWOS and at Facebook at ESPNWWOS.


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No. 1 Scottish Gympie Mine and Battery is a heritage-listed mine at Old Brisbane Road, Monkland, Gympie Region, Queensland, Australia. It was built from  to . It was added to the Queensland Heritage Register on 21 October 1992.

History

The lease occupied by the site was taken up in 1889 as the "No.1 Eastern" mine, forfeited and taken up as the No.3 Great Eastern mine in 1891, but went into liquidation soon thereafter. Gympie Goldmines (Eastern Monkland) Company was formed, and was sold to Scottish investors in 1895, becoming the Scottish Gympie Gold Mines Limited with its head office in Glasgow.

By the following year the shaft was down , the deepest on the field. At this time companies started considering cyaniding their tailings dumps and the company increased the number of stampers in its battery by 50 in 1898. In 1904 the battery was reported to have 125 head of stamps and 394 men employed, and to be raising  of ore for crushing each year, with an estimated ore reserve for another ten years.

The company closed the mine in 1923 and in the following year a syndicate of 19 men was formed to purchase the lease over the shaft and winding gear, and mining recommenced intermittently. However the lease was relinquished in 1924 and an auction sale of machinery held. In 1927 W. Runge and O. Alexander took over the mine and battery site and established a cyaniding plant. The leases were held by the Runge family until taken over by the Gympie City Council.

The mine was the most productive in the Gympie goldfield producing  of gold from  of ore between 1867 and 1923.

Description
The place consists of:
 The standing assay office which has been conserved
 Concrete foundations of the compressor room, engine room and secondary crushing equipment
 A 4-head prospecting stamp battery
 Engine foundations
 Battery foundations
 Very large in-ground water tank
 Capped shaft, headframe foundations and foundations of the winding house.

Heritage listing
No. 1 Scottish Gympie Mine and Battery was listed on the Queensland Heritage Register on 21 October 1992 having satisfied the following criteria.

The place is important in demonstrating the evolution or pattern of Queensland's history.

The No.1 Scottish Gympie mine and battery is significant in the evolution and pattern of Queensland history because it was the most successful mine in the Gympie Goldfield, which had a major impact on Queensland's development and was a major example of the impact of overseas investment on the development of the State.

The place demonstrates rare, uncommon or endangered aspects of Queensland's cultural heritage.

The place is a rare aspect of Queensland's cultural heritage and contains the only readable evidence of historical mining activity in Gympie.

The place has potential to yield information that will contribute to an understanding of Queensland's history.

The place demonstrates, through surviving foundations and the intact assay office, the characteristics of a large-scale gold mining works and as such has the potential to provide information to increase our understanding of battery technology and management.

The place is important in demonstrating the principal characteristics of a particular class of cultural places.

Significant as the most intact surviving example of mining remains in the Gympie field and probably the largest gold battery remains in Southeast Queensland.

References

Attribution

External links

  — includes photos and audio-visual material

Queensland Heritage Register
Monkland, Queensland
Mines in Queensland
Articles incorporating text from the Queensland Heritage Register
Mining in Queensland

redpajama_set_name: RedPajamaWikipedia


This breed of dog is extremely rare and it almost went extinct in the 1940's. This breed is an ancient one and it dates back to the age of Vikings in Sweden. Over a full melena ago this breed was commonly used to heard sheep and cattle. The Vallhund is a smaller breed of dog with shorter legs. They look a little like a corgi but with a larger frame. They are quite a large sized dog to have short legs. Some of this breed has curly tails whilst others have a smaller stump like tail. The Vallhund has a short coat that is relatively coarse. The top coat on the animal is relatively thick and close to the body whereas the undercoat is much softer. They range in color from grey to brown and red but they normally have lighter colored hair throughout their muzzle and chest. Overall this breed offers a great companion. They absolutely love attention and they often like to show off as well. With ample energy and the need for contact we offer plenty of breaks for this type of breed. We offer plenty of affection and responsiveness throughout any transport. Overall they are very even tempered with most people and the Vallhund is also relatively obedient/fairly easy to train. Although they began their lineage as farming dogs today they are excellent companion pets as well as great family dogs. They are the perfect compromise for those that want a larger dog without sacrificing too much space. We know that this breed especially can have issues in warm climates and we will always provide ample water and breaks during transport. While this breed does generally stay healthy and enjoy a long life, heat and dehydration can cause health issues especially over long trips. We feel very lucky to have worked with such a rare breed!


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The PPM1 is a trace moisture analyzer designed specifically for monitoring moisture levels in dew point and PPM units. This trace moisture analyzer utilizes an electrochemical (P205) sensor in combination with a proprietary semi permeable diffusion membrane. The principle of operation applies the Faraday's Law of Electrolysis which measures the dissociation current making it a fundamental measurement of the moisture present. The PPM1 is ideally used in relatively clean, dry, inert gas applications.


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Q: Prove $\frac{1}{2 \pi} \int_0^{2\pi} \frac{1 - r^2}{1 + r^2 - 2r \cos{t}} dt = 1$ using contour integration The question is to solve the integral using concepts of contour integrals:
$$\frac{1}{2 \pi}   \int_0^{2\pi} \frac{1 - r^2}{1 + r^2 - 2r \cos{t}} dt = 1$$

A: Remark: the integrand $P_r(t)$ is known as the Poisson kernel and the result follows immediately from a term-by-term integration of the normally converging (when $0\leq r<1$) series $P_r(t)=\sum_{n\in\mathbb{Z}}r^{|n|}e^{in t}$ over $[0,2\pi]$. But since you want contour integration...
Hint: when $0<r<1$ use Cauchy's integral formula given that
$$
\frac{1-r^2}{1+r^2-2r\cos t}=\mbox{Re}\left( \frac{1+re^{it}}{1-re^{it}}\right)=\mbox{Re}\left( \frac{1+z}{1-z}\right)\qquad z=re^{it}
$$
and factor $r^2$ out in the numerator and the denominator to reduce to the latter when $r>1$, which yields $-1$.
Details upon request: when $0<r<1$, the function$f(z)=\frac{1+z}{1-z}$ is holomorphic on the open unit disk, which contains $\gamma$ the circle of radius $r$ and center $0$. So by Cauchy's integral formula
$$1=f(0)=\frac{1}{2i\pi}\int_\gamma \frac{f(z)}{z}dz=\frac{1}{2i\pi}\int_0^{2\pi} \frac{1+re^{it}}{1-re^{it}}\cdot \frac{ire^{it}}{re^{it}}dt=\frac{1}{2\pi}\int_0^{2\pi} \frac{1+re^{it}}{1-re^{it}}dt$$whence
$$1=\mbox{Re}\left(\frac{1}{2\pi}\int_0^{2\pi} \frac{1+re^{it}}{1-re^{it}}dt\right)=\frac{1}{2\pi}\int_0^{2\pi}\mbox{Re}\left( \frac{1+re^{it}}{1-re^{it}}\right)dt=\frac{1}{2\pi}\int_0^{2\pi}\frac{1-r^2}{1+r^2-2r\cos t}dt.$$
When $r>1$, we have
$$
\frac{1}{2\pi}\int_0^{2\pi}\frac{1-r^2}{1+r^2-2r\cos t}dt=\frac{1}{2\pi}\int_0^{2\pi}\frac{-r^2(1-r^{-2})}{r^2(1+r^{-2}-2r^{-1}\cos t)}dt=-1
$$
by application of the above to $0<r^{-1}<1$.
For $r=0$, we find $1$. And for $r=1$, we get $0$.

A: Let $$I(r) = \dfrac{1}{2 \pi} \int_0^{2\pi} \frac{1 - r^2}{1 + r^2 - 2r \cos{t}} dt \tag{$\spadesuit$}$$
Splitting the integral from $0$ to $\pi$ and $\pi$ to $2\pi$, changing $t \to \pi-t$, in the second integral, we get
$$I(r) = \dfrac{1}{\pi} \int_0^{\pi} \frac{1 - r^2}{1 + r^2 - 2r \cos{t}} dt = \dfrac{1}{\pi} \int_0^{\pi} \frac{1 - r^2}{1 + r^2 + 2r \cos{t}} dt$$
Replacing $t$ by $2t$ in $(\spadesuit)$, we get that
$$I(r) = \dfrac1{\pi} \int_0^{\pi} \frac{1 - r^2}{1 + r^2 - 2r \cos{2t}} dt = \dfrac1{\pi} \int_0^{\pi} \dfrac{1 - r^2}{(1+r)^2-4r \cos^2(t)} dt$$
\begin{align}
I(r^2) & = \dfrac1{\pi} \int_0^{\pi} \dfrac{1 - r^4}{(1+r^2)^2-4r^2 \cos^2(t)} dt\\
& = \dfrac1{2\pi}\left(\int_0^{\pi} \dfrac{1 - r^2}{1+r^2-2r \cos(t)} dt + \int_0^{\pi} \dfrac{1 - r^2}{1+r^2+2r \cos(t)} dt\right)\\
& = I(r)
\end{align}
Now note that $I(r)$ is continuous for $r \in [0,1)$ and $r \in (1,\infty)$. Now note that
$$I(0) = 1 \text{ and } \lim_{r \to \infty} I(r) = -1$$
Since $I(r) = I(r^2)$, we have $I(r) = \cdots I(r^{2^n})$. For $r\in [0,1)$, we have
$$I(r) = \lim_{n \to \infty} I(r^{2^n}) = I(\lim_{n \to \infty} r^{2^n}) = I(0) = 1$$
For $r\in (1,\infty)$, we have
$$I(r) = \lim_{n \to \infty} I(r^{2^n}) = I(\lim_{n \to \infty} r^{2^n}) = -1$$
Hence,
$$I(r) = \begin{cases} 1 & \text{ if }r\in[0,1)\\ 0 & \text{ if } r = 1\\ -1 & \text{ if }r \in (1,\infty)\end{cases}$$

redpajama_set_name: RedPajamaStackExchange


text:
5 special women to admire for their courage
Some people just stay with you because they were outstanding in doing things in a certain moment or throughout their life. Through history, many women have had immeasurable impact on culture and society. Women's History Month is a month dedicated to reflect on the often-overlooked contributions of women. Therefore, I made a short list of courageous women that touched me. Read my latest post for 5 special and courageous women to admire.
1. Christiane Amanpour – Journalist
I was too young when journalist Christiane Amanpour aired on CNN. But I have definitely watched her asking political leaders like Iranian President Hassan Rouhani and former Libyan leader Muammar Gaddafi critical questions in her interviews, which often led to awkward situations. She has been courageous in interviewing those people and risked her life for it many times. She is one of the reasons I fell in love with journalism and I like her approach of finding truth as a journalist.
https://www.youtube.com/watch?v=Y1rpzUD3vgE
2. Rosa Parks – Civil rights activist
In Alabama in 1955, Rosa Parks refused to give up her seat to a white passenger on the bus she was travelling on. Because of that courageous move, Parks was convicted of violating segregation laws, which in those days meant that people of color had to take a seat in the back of the bus and white people were allowed to sit in front. This occasion soon became a catalyst for the civil rights movement in the United States, as there was a bus boycott organized by the leaders of the local black community. Rosa Parks became a nationally recognized symbol of dignity and strength in the struggle to end entrenched racial segregation.
https://www.youtube.com/watch?v=v8A9gvb5Fh0
3. Greta Thunberg
We are in the middle of the biggest crisis of the history of human kind. Climate change is real and it's our biggest and most urgent challenge right now. If there is one person that used her voice to remind us of that – even at the age of just 15 years old – it's definitely Greta Thunberg. She mentioned many times that we should treat climate change as a real crisis like COVID-19 is now and that we are not doing enough.
https://m.youtube.com/watch?v=KAJsdgTPJpU
4. Nellie Bly – Investigative Journalism Pioneer
In 1885, Nellie Bly wrote and published a searing letter of response to a man who cynically questioned what girls are good for. A couple of years later Nellie Bly published a groundbreaking exposé of abuses at insane asylums. This publication led to some of the first legal protections for the mentally ill. On top of that, Bly became the first woman to report from the Eastern Front in WWI. In the factories she founded and operated in an era when factory workers — mostly uneducated young women — toiled in gruesome conditions for meager pay. She modeled social welfare by providing honorable wages and a humane environment for her workforce of 1,500. She invented, patented, produced, and taught Americans how to use the nation's first successful steel barrel.
Long story short, Nellie paved the way for women in a time when women didn't even have the right to vote. Nellie Bly refused to accept the status-quo and because of that courage, she belongs in my list.
Directed by Penny Lane
5. Oprah Winfrey
It's not the first time I mention Winfrey, and it won't definitely not the last time that I mention her in my writings. Winfrey used her television platform to have conversations about topics that matter. From child abuse to sexual assault, Oprah showed how those topics may appear in our lives, how it looks like, how people in those situations dealt with it and recovered from it. Year after year, she managed to let millions of viewers see themselves in the stories of others. I think she showed us how television can bring people together and let us feel what connects us rather than what divides us. Also Winfrey belongs in my list of courageous women.
https://www.youtube.com/watch?v=fohCkaIhnBc
Last note
This was my list of 5 phenomenal women. Let me know which courageous women you think belong in this list. You can use the comment section below.
https://www.lisanneswart.com/wp-content/uploads/2021/01/chain-690088_1280.jpg 1280 718 Lisanne Swart Lisanne Swart https://www.lisanneswart.com/wp-content/uploads/2021/01/chain-690088_1280.jpg January 1, 2021 October 8, 2022
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Warm greetings to each of you, whether you are a member with decades of being with us, or if you are part of the recent growth of our sangha. We are delighted and grateful for your presence. This letter is a brief update of organizational matters. It is our intention to maintain clear and consistent communication within the sangha.
There have been many changes recently in our community, how it looks and how it interacts. And more change is likely to arrive. One thing has not changed - the mission of MMC remains the realization of all beings, for the benefit and happiness of all. To support that mission, it is the goal of MMC to build and sustain a community committed to the practice of realization.
After more than twenty years of building the MMC community and leading it through all stages of its growth and development, Michael Gregory is stepping back from administrative duties. This change will permit him to focus his attention at its highest use - teaching, writing, guiding retreatants. And he will continue leading the educational/ teacher training - content and modules. The changes in the administrative structure of MMC will create a container to minimize demands on his time away from these core concerns. Michael's devotion has been unbounded in the past decades. The community as a whole expresses it gratitude to him by the devoted practice of each of us, and by our efforts to maintain the vitality of MMC. Fortunately Michael remains close-by, and will serve the MMC Board in an advisory role!
Building a stable community requires an organizational framework that is not reliant on a single person, but is self-sustaining. To that end, MMC has taken some first steps. A group of committees, from Maintenance to Technology to Marketing, has developed, as needs arose. These committees will be formalized, with committee heads, regular meetings and communication of their work to the community. Additional committees may be formed as new needs rise.
To oversee and direct the work of the committees, MMC has created a new Board of Directors. These individuals, all experienced and dedicated members and meditators, will be responsible for facilitating the business side of our expanding community. The Board will serve as a public face of the community when needed and will expedite communication within the community. Current members include Christian Strachan, Elizabeth Leahy, Rose Costello, and Davita Moodley, Additional board positions and members may be added.
The ongoing stability of the organization of MMC depends on a transparent and reliable financial structure. Going forward, the accounting and bookkeeping functions will be handled by an outside firm hired by MMC. This work has been done by volunteers in the past, Linda Gregory for a very long time and more recently, Theresa Sullivan. Warm thanks to both for their dedicated service.


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Home > More > Hot Links > BTS V's 'Christmas Tree' debuts on Billboard's Hot 100 chart
BTS V's 'Christmas Tree' debuts on Billboard's Hot 100 chart
V, a member of the K-pop supergroup BTS, is about to make it onto the Billboard main singles chart for this week with his individual single "Christmas Tree."
The song will debut at No. 79 on the Hot 100 for this week, Billboard said on its Twitter on Tuesday (U.S. time), with the chart set to be refreshed in a day.
Released on Dec. 24, "Christmas Tree" is a song from the soundtrack of the South Korean TV series "Our Beloved Summer," starring Choi Woo-shik of the Cannes-winning Korean film "Parasite."
The feat will make V the third BTS member to chart an individual single on the Hot 100 after J-hope with "Chicken Noodle Soup" and Suga with "Daechwita" and "Girl of My Dreams."
A promotional poster for "Christmas Tree," a drama soundtrack sung by BTS' V, provided by Most Contents. (PHOTO NOT FOR SALE) (Yonhap)
'Kill This Love' becomes second BLACKPINK video to top 1.5 billion YouTube views
Enhypen's repackage album sold 510,000 copies in first week


Wicks pipes are pre-voiced before they ever go into the organ. Pre-voicing simply means the mouth of each pipe is cut-up, the toe holes are opened to give each pipe the required relative volume, the pipes are cut to the correct length, and the languids are adjusted so that the pipes speak uniformly as desired. Reed ranks are prepared and voiced thoroughly as well. This takes place in one of Wicks several air-conditioned voicing studios, each designed to make the job of voicing as simple as possible for our trained voicers. Having handy tools and space to work greatly shortens the amount of time required to bring the pipes into speaking condition. Many builders choose to wait until the pipes are in place and the organ has been built to do this work on-site. While admirable, this frequently adds many weeks to the installation process and forces the voicer to work in undesirable situations.
Having our own pipe shop means our voicers can do an even better job. Should a problem occur, a pipe be damaged, or cut-up too far, the voicer can have the pipe repaired or even replaced in a very short time. Other builders often have to resort to sending the pipe away to be repaired, or continuing despite the damage.
Wicks pipe organs are undoubtedly the most reliable on the market today, thanks to careful construction techniques, high quality materials, and our DIRECT-ELECTRIC® action. The first units installed over 85 years ago are still working today. Every pipe is voiced on this action before they go into the organ to ensure proper speech characteristics. Newly developed DIRECT-ELECTRIC® unit styles allow their use in high wind-pressure organs. In addition, the use of expansion chambers on the lower notes and reed ranks helps the pipes speak properly on these higher wind pressures. We use reservoirs to provide stable wind to all pipes. Our chests are the simplest in the industry, while still being constructed of high-quality sitka spruce and poplar to make them strong, yet light.


text:
Our Man Flint (1966) and In Like Flint (1967)
A quick diversion from the Buck Rogers festivities to look back at two James Coburn spy flicks from the 1960's. In them, Coburn plays Derek Flint, a highly individualized former spy, and top man in his field. He is a secret agent, scientist, inventor... He can talk to dolphins. Oh, and the women fall all over him. These are corny, comical, jiggly spoofs of James Bond films that are superficially fun, but there is a sinister slant to In Like Flint that really bothered me. But first...
Our Man Flint has our hero battling "Galaxy," an international syndicate bent on world domination through use of a weather control device. We find out they are led by a group of scientist who have deemed man to ignorant to rule himself. They plan to create a Utopia led by the best and brightest. Once Flint encounters them, they offer him a place in their organization; after all, he is a talented, intelligent man. He is exactly what they are looking for. He claims their price is too high. He's all into freedom, baby, but not freedom as dictated by others. That's not freedom, you dig?
Now, In Like Flint follows the same basic agenda. This time a group of powerful women plan to take over the world. They have been brainwashing women through hairdryers to instill a dissatisfaction with the male world. They have massed an army of women, they have infiltrated top levels of the government, and even replaced the president with a disguised actor. The threat of nuclear annhilation is their trump card, as they have armed a space station with nuclear warheads. Again, Flint disagrees with their ideas on Utopian civilization, and sets out to twart them, but it turns out that those ranking government officials have turned coat and plan to take over the world themselves.
The problem I have with In Like Flint is that the character is supposed to be this enlightened fellow that women love because he treats them with respect (after a fashion), but when the women antagonists explain their plan, he laughs them off. There is no way women could run the world. That's crazy. Even with a nuclear arsenal, they really gotta have penises to be in control.
Obviously, I am thinking a lot into this movie, but his attitude so flies in the face of the character as to ruin the entire film for me. And this film has Yvonne Craig in it, albeit briefly. I don't want to hate anything with Yvonne in it.
Anyway, there are a lot of reasons to watch these movies, if you have not. First, Austin Powers is a total ripoff of these films. Second, the swingin' sixties at their swinginest! Also, the first movie has a brief Tura Satana appearance, while the second, as mentioned, contains Yvonne Craig as a Russian ballerina. Bikinis. Corny henchmen uniforms. Jet setting. Technicolor. Just eat your popcorn and bask in the bright colors and swingin' jazz, and forget all that sexist stuff I mentioned being there.
Labels: Flint, James Bond, James Coburn, Yvonne Craig
I always felt that these two films were definitely products of their times and certainly reflect their attitudes and, obviously, they are totally riffing on the Bond films but with tongue firmly planted in cheeck. I haven't had a chance to watch IN LIKE FLINT but I quite enjoyed OUR MAN FLINT and I think that's due in large part to the groovy production design, snazzy soundtrack and the performance of James Coburn who cruises through the film with a confident smirk.
You are also right on the money about how the AUSTIN POWERS films totally ripped off these films. They should sue for plagiarism! Scary...
Darius Whiteplume said...
I found it hilarious that Flint was a Yoga master, or whatever (he can stop his heart, for crissakes) yet he was always smoking! :-)
In Like Flint is perhaps even more spoofy than the first. Our Man Flint, while comedic, seems a lot like the Matt Helm movies (though I must admit I have never seen one). In Like Flint is almost a spoof of the first film.
Apparently there was going to be a tv show too. The pilot is supposed to be on one of the Ultimate Flint discs.
Yeah, I've been meaning to pick up that ULTIMATE FLINT box set - it looks like it has a nice set of extras. Plus, just to have the films letterboxed.
Yeah, I hate full screen to the point of snobbery. I get so pissed when I buy a fullscreen DVD by mistake. "Why do they makes these? And why don't they print 'full screen version' bigger?!?"
ColKillgore said...
When I first saw the Flint movies I liked them, but thought James Coburn could have tried a little harder to make his martial arts moves more realistic. Years later I saw a documentary on Bruce Lee and low and behold there is James Coburn in Burce Lee's backyard sparring. Of all the unreality of the movies it seems that James Coburn's martial arts was the real deal.
@Kilgore - I thought I remembered that. So many stars worked with Lee, it is hard to keep track. Colburn does seem to be from the William Shatner/James T Kirk school at times, but I guess a lot of that has to do with the stunt coordinator (or lack of) and skill of the other actors.


text:
Summary of the year 2021
Gender Equality and Non-Discrimination
Democracy and the Rule of Law
Activists in lockdown
Defending Rights
Support activists
Application and reporting guides and forms
Reporting fraud and abuse
What is KIOS?
History, founders and the board of directors
Businesses are obligated to ensure that their operations do not cause human rights violations. KIOS supports local organisations which report human rights violations caused by business operations, and defend the rights of people if businesses have trampled on them.
Business operations impact human rights in many different ways. In poor countries, land rights are often vital to peoples' livelihoods. Oil drilling, the mining industry and various infrastructure projects affect the land rights of local people and may lead to forced evictions. Polluting factories and environmental degradation threaten people's right to a healthy and safe environment. Businesses may trample on employees' rights, particularly in the case of a persons in a vulnerable position such as migrant workers.
Corporate accountability strengthens human rights
Corporate accountability means the understanding of a company of the positive and negative impact of its operations on society and its responsibility for monitoring the ethics of the entire production cycle. This means that businesses must also prevent human rights violations in the operation of subcontractors.
More and more attention is being paid to the role of companies in Finland and around the world, because business operations cause many human rights violations. On the other hand, businesses also have plenty of opportunities to promote the realisation of human rights, for example, by strengthening the livelihood of communities or by hiring people from groups that are discriminated against in society.
CJGEA defends the right to a clean and healthy environment in Kenya. Photo: CJGEA
Organisations defend the weakest
KIOS supports local human rights actors in East Africa and South Asia who defend communities or workers whose rights are threatened by businesses. Organisations may report possible environmental issues or human rights violations and enter into dialogue with businesses and the authorities. Some activists we support campaign in their communities to increase the awareness of the impact of business operations. They may document human rights violations, so that businesses and authorities monitoring them can be held accountable. Some take the cases to court to defend the rights of local people.
In Kenya, KIOS has supported the fight of a community threatened by the lethal lead emissions from a metal smelter next to their homes. Read more about their achievements
In Uganda, an organisation supported by KIOS mobilised rural communities to oppose a private company's exclusive right to use crater lakes. In Uganda, KIOS has also supported the cooperation of organisations in promoting corporate accountability and work to defend the rights of locals in the oil industry area.
In Nepal, KIOS has supported the rights of migrants and work promoting the land rights of indigenous people.
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text:
Carers Network is committed to encouraging carers to gain confidence, make their own choices and support each other in the City of London.
Carers Network, Artizan Street Library1 Artizan StreetLondon
info@carers-network.org.uk
Carers Network City of London
Carers Network City of London, provides support, information and advice to carers aged 18 or over who are looking after someone aged 18 or over and living with health, disability or care needs. The person being cared-for may be an: Adult with physical disabilities Adult…
Office 8 Beethoven CentreThird AvenueLondonW10 4JL
07980 744 511 020 8960 3033 - Carers Network Westminster
rose.bernstein@ageukeastlondon.org.uk
The Cartoon Museum
From the cut and thrust of today's leading cartoonist, including Matt, Steve Bell, Peter Brookes and Gerald Scarfe, to the exploits of classic comic characters such as Dennis the Menace, Dan Dare, Andy Capp, Rupert and Alex, the Cartoon Museum exhibits the best of British…
35 Little Russell StreetLondonWC1A 2HH
info@cartoonmuseum.org.uk
CASA Family Service
CASA Family Service helps children, young people and families who are having difficulties because of parental use of alcohol or other drugs. We offer non-judgemental and respectful support, focusing on the needs of children and young people, to help parents to provide a safer and more secure…
86 Durham RoadLondonN7 7DT
cfs@blenheimcdp.org.uk
Cass Holiday Playcentre Scheme (Years 1-6)
Monday to Friday 8.30am-5.30pm. Core hours: 10am-4pm
The City of London Child and Family Centre Holiday Playcentre Scheme runs every school holiday except Christmas week. Based in The Aldgate Schooll, we use many of the school's great facilities including the gym, playground and kitchen, and offer a programme of diverse, planned activities with staff on hand to enhance…
St James' PassageDuke's PlaceLondonEC3A 5DE
020 7283 1147 (school general number)
office@sirjohncassprimary.org
CEA Card
The CEA Card is a national card scheme that helps people with disabilities go to the movies. It allows them to obtain ONE free ticket for the person accompanying them, who is providing the assistance they require as a result of their disability. This can…
CH5 9BW
Central Africa's Rights & AIDS (CARA) Society
We are an an independent international charity. We rely on our members and the generosity of the public in securing donations and legacies so that we can continue the work we provide in the UK and AfricaOur main activities include HIV/AIDS prevention, care and support…
18-22 Ashwin StreetHackneyLondonE8 3DL
info@cara-online.org
Central Criminal Court
Universally known as the Old Bailey, the court has been London's principal criminal court for centuries. It hears cases from all over England and Wales as well as the Greater London area. Access to the public galleries is free and based on a first come first…
Old BaileyLondonEC4M 7EH
ccc.enquiries@cityoflondon.gov.uk
Central Health Physiotherapy Chancery Lane
The Chancery Lane Physiotherapy Clinic in Central London has a team of physiotherapists, massage therapists, Pilates instructors and visiting podiatrists. They also have a state-of-the-art fitness studio for rehabilitation, personal training, Pilates and High intensity interval training. They aim to help patients to restore, maintain and…
Central Health Physiotherapy Chancery Lane53-64 Chancery LaneLondon
reception@central-health.com
Central London Osteopathy and Sports Injury Clinics
The Sports Injury Clinic's physiotherapists are used to both acute and chronic problems and link the muscles to the bones in their treatments. Their physiotherapists assess movement, strength, endurance and other physical abilities. They do program planning and education to restore movement, reduce pain. They give individualized treatment of…
325 - 327 Old StreetLondon City
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text:
(LS) Life Sciences (13) Apply (LS) Life Sciences filter
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01-07-2019 | © Zentrum für Telematik
Satellites: small is beautiful
Spacecraft follow the same tendency as our computers to become continuously smaller, but more connected. In his ERC grant "NetSat", Klaus Schilling, from the Zentrum für Telematik in Würzburg, studies control strategies for small pico-satellites in formation, in order to achieve the best performance through their cooperation.
24-06-2019 | © M.J. Ventas Sierra
Unravelling masons' secrets to help the restorers of Notre-Dame
New insights into how the great Gothic vaults were constructed helps restorers of the future When we think about fascinating architectural work, vaulted ceilings may not necessarily be the first elements to spring to mind. However, they were key to limiting interior damage when a fire broke out beneath the roof of the Notre-Dame of Paris in April of this year. While medieval stonemasons seemed to know very well what they were doing, today their techniques are still not completely understood. The challenge of restoring Notre Dame presents an opportunity for their mystery to finally be unravelled.
Wake-up call for soil microbes
Our soils are inhabited by millions of microorganisms; however, the majority of them lay dormant. In her ERC project, Prof. Dagmar Woebken explores the mechanisms that allow soil microorganisms to go into dormancy and thus survive unfavorable conditions. It is further the goal to reveal the environmental signals that lead to their resuscitation to perform important ecosystems functions.
24-06-2019 | © istockphotos.com
Life in the deep – microbes of the abyss
The deep seafloor covers around 70% of our planet's surface and is home to a diverse community of microorganisms, mostly bacteria. These single-cell life forms inhabit some of the most extreme places in the world, with freezing waters, permanent darkness, high pressure and little food. ERC grantee Antje Boetius studies these microbes in the abyss and their important role for the Earth's nutrient cycles.
29-11-2018 | Pictures and portrait: © Saarland University, HCI Lab
Tech-filled tattoos to interact with the surrounding world
The increasing development of wearable technology sparks the need for new, innovative ways to interact with our shiny gadgets. Deviating from the conventional approach based on touch-sensitive devices, Prof. Jürgen Steimle aims at producing body-worn user interfaces that can be applied directly on the skin. Highly personalised, biocompatible and ultrathin, these devices will seamlessly blend with the human skin to create a technological extension of our body.
Centre stage: the vital social role of applied theatre
Applied theatre tells a story not for the purposes of entertainment but for social, economic, political or therapeutic reasons. Prof. Matthias Warstat, funded by the ERC, wants to know more about the growth and impact of this form of theatre across the world.
Small, but cooperative: the future of spacecraft systems
Will spacecraft follow a similar evolution to computers? While information processing in the last century was performed by large mainframe computers, today, networked smart phones dominate the market. In spacecraft engineering a similar paradigm shift is apparent: from traditional single, large, and multifunctional satellites towards groups of very small satellites that cooperate together. Professor Klaus Schilling, in his ERC project "NetSat", addresses crucial challenges to enable small satellite formations to self-organise. This offers innovative application perspectives in areas like Earth observation, science exploration or telecommunications.
01-10-2018 | The tumor accumulation of nanomedicine formulations can be used to predict their efficacy. This image exemplifies that in those tumors which have the highest levels of nanomedicine accumulation (blue-to-yellow clouds; imaged via FMT imaging), therapeutic
Medical imaging: Can we predict how cancer patients will respond to nanotherapies?
Despite holding out promise for cancer treatments, nanomedicine lacks the means to predict patient response to tumour-targeting therapy. Prof. Twan Lammers has devised imaging which differentiates between those likely to benefit and those unlikely to do so. A significant barrier for the nanopharmaceutical industry tackling cancer is that while some patients treated with nanomedicine show major improvements in survival rates and quality of life, many others do not respond well. This can result in delays in receiving appropriate treatment. A step forward would be the ability to differentiate likely responders from non-responders, prior to their selection for studies or treatment.
02-08-2018 | ©HITS (Heidelberg Institut für Theoretische Studien)
Understanding the deformation spaces of geometric structures
Funded by the ERC, Prof. Anna Wienhard studies several new geometric forms that have been discovered over the past 20 years. These structures are closely related to the generalisation of Teichmüller space, which describes how the surface of a pretzel can be endowed with the geometry of an Escher painting.
25-07-2018 | © Juergen Knoblich
Cerebral organoids: an innovative treatment for neurological disorders
Being able to generate human tissue in vitro in a dish is expected to revolutionise biomedical research. European researchers generated brain organoids to study the mechanisms of various neurological disorders and discover novel drugs to treat them.


text:
#pragma once

#include <string>

#include "envoy/server/filter_config.h"

#include "external/envoy/source/common/common/statusor.h"

#include "api/server/response_options.pb.h"

#include "source/server/http_filter_config_base.h"

namespace Nighthawk {
namespace Server {

// Basically this is left in as a placeholder for further configuration.
class HttpTestServerDecoderFilterConfig : public FilterConfigurationBase {
public:
  HttpTestServerDecoderFilterConfig(const nighthawk::server::ResponseOptions& proto_config);

  /**
   * @return std::shared_ptr<const nighthawk::server::TimeTrackingConfiguration> the startup
   * configuration for this filter, which may get overridden by in-flight headers.
   */
  std::shared_ptr<const nighthawk::server::ResponseOptions> getStartupFilterConfiguration();

private:
  std::shared_ptr<const nighthawk::server::ResponseOptions> server_config_;
};

using HttpTestServerDecoderFilterConfigSharedPtr =
    std::shared_ptr<HttpTestServerDecoderFilterConfig>;

class HttpTestServerDecoderFilter : public Envoy::Http::StreamDecoderFilter {
public:
  HttpTestServerDecoderFilter(HttpTestServerDecoderFilterConfigSharedPtr);

  // Http::StreamFilterBase
  void onDestroy() override;

  // Http::StreamDecoderFilter
  Envoy::Http::FilterHeadersStatus decodeHeaders(Envoy::Http::RequestHeaderMap&, bool) override;
  Envoy::Http::FilterDataStatus decodeData(Envoy::Buffer::Instance&, bool) override;
  Envoy::Http::FilterTrailersStatus decodeTrailers(Envoy::Http::RequestTrailerMap&) override;
  void setDecoderFilterCallbacks(Envoy::Http::StreamDecoderFilterCallbacks&) override;

private:
  void sendReply(const nighthawk::server::ResponseOptions& options);
  const HttpTestServerDecoderFilterConfigSharedPtr config_;
  absl::StatusOr<std::shared_ptr<const nighthawk::server::ResponseOptions>> effective_config_;
  Envoy::Http::StreamDecoderFilterCallbacks* decoder_callbacks_;
  absl::optional<std::string> request_headers_dump_;
};

} // namespace Server
} // namespace Nighthawk

redpajama_set_name: RedPajamaGithub


text:
Vintage Pulp May 8 2018
For the last time! I gave all my spare change to the guy who pretends he's a statue!
Drum circles always end up sounding exactly the same. And we say that with respect, since both of us here at Pulp Intl. are what you'd call professional drummers. No joke. It's sort of how we met. During that auspicious encounter BB said to me, "Other drummers hate me." Me: "Why is that?" BB: "Because I'm better than them." True story. Charlotte Jay's thriller Beat Not the Bones marches to the beat of a different drummer. The novel, which first appeared in 1952 and in the above Avon paperback edition in 1955, involves a sheltered Australian woman who ventures to the fictional New Guinean town of Marapai to prove her husband, who worked there as a government anthropologist, was a murder victim rather than a suicide. The book was well received and won Jay, aka Geraldine Halls, the inaugural Edgar Award for best mystery novel of the year.
Our expectations, in that case, were high. But were they perhaps a bit too high? Jay's prose is evocative and the setting is fascinating, but the heroine of Beat Not the Bones, tender young Emma Warwick, tries the patience just a little as she sort of gasps, swoons, and palpitates her way toward the answer she seeks. Was her husband murdered because he refused to approve the application for a gold claim? Is there a more sinister plot afoot? She can only know by embarking on a journey to the country's steamy interior. This trip into the heart of darkness, the dramatic crux of the book, doesn't begin until more than three quarters of the way through. But we knew it was imminent, and that made us impatient. Just get to the jungle journey! Beat not the bones! Get to trekkin' already! Well, Emma gets there eventually.
As she draws closer to the center of the mystery she grows emotionally stronger, hindered by some and helped by others, particularly a local acquaintance named Hitolo who works for the state but still has jungle roots. This is the type of novel where grown Papuan men like Hitolo are all "boy," rampaging predatory colonialism is "opening up the country," and colonials are under the delusion that their presence is helpful to the locals. But Jay, the omniscient voice of the narrator, makes clear that none of these beliefs are true. While the question among the characters is whether the very environment corrupts white men, the suggestion made by the author is that the corruption is not found there, but brought there, stowed away in the colonials' own souls.
To put a finer point on it, what truly corrupts colonials is the blatantly evil act of stealing native people's past by destroying their traditions and beliefs, and also stealing their future by taking possession of everything that holds value in the modern world that awaits them. In the face of such a robbery that leaves its victims doubly impoverished all justifications are hollow; they're a farce, winkingly acted out as cover for a greedy rampage. But we anthropologize. The jungle journey is the key to this book, and whether you like it depends on whether you consider that section worth the wait. Like your average drum circle Beat Not the Bones could have been more varied, more streamlined, more nimble, but when the end comes it's with a thunderous crescendo and a sense of waking from a dream.
Papua New GuineaAvon PublicationsEdgar AwardCharlotte JayGeraldine Hallscover artliterature


text:
Q: How can I retrieve CSV file inside of the Unzip folder? I am trying to read and parsed all the CSV files, these files are inside of extracted zip file, but unfortunately, I'm only getting this (No such file or directory) - How can I get inside that folder and read those files? Take note that this folder is already unzipped.
I'm also thinking, that if that is not possible - is there any way that I can extract the zip file to files only, for example below:
Zip File: ZipFolder.zip

Expected: (No folder at all, automatically the files is on the target location already).
CSVFile1.csv
CSVFile2.csv

Can someone help me to get through this? your help is appreaciated.. Thank you!


Automakers Nissan and Renault will sell electric vehicles in Portugal in 2011 and the allied companies have partnered with the government in an attempt to create a national network of charging stations.
Nissan has said it will sell electric cars globally in 2012, but the technology is still being developed. In July, Carlos Ghosn, chief executive of the French and Japanese automakers, and Portuguese Prime Minister Jose Socrates announced they would work together to raise awareness about the vehicles and try to make them easier to fuel.
Nissan has aggressively pursued deals with cities and governments on electric vehicles, as soaring gas prices and worries about global warming make the green technology more appealing.


TSR.LIVE is one of the most known tamil radio station with listeners from all over the world. TSR.LIVE started their first streaming in 1999 using Mycaster. 1999 TSR.LIVE plays the best in Semi Old Tamil hits, Tamil remixes, New Tamil/Hindi movie hits, Live hosts by fame deejays and has a growing fan community. Their live streams were broadcasted using Live365.
In 2002 TSR.LIVE combined with planetindians.com (tamil malaysian portal site).
2004 one of the majority hits in TSR.LIVE history with listeners over 800 unique peak listeners. At this time they were with their proud sponsor (AractelNetworks) also knows as Tamilgrounds.
2006 TSR.LIVE continued streaming live station combined with Superstarzfm.
2007 TSR.LIVE launched their new webspace V.2. TSR.LIVE upgraded their dedicated severs and its own crew.
The aim behind TSR.LIVE is to offer a pure LIVE Tamil streaming with selection of tracks for ALL online listeners.


Analysis of a program generates a statement about the possible execution states, often expressed as annotations to the program. The statement is approximate but should be provably "safe" wrt to the operational semantics. ("safe" means that at least all possible computations are covered).
Analysis by abstract interpretation was first proposed by Patrick and Radhia Cousot [POPL'77] for use in imperative programming languages. Casting the analysis as abstract interpretation is a way of formally motivating the statement that an analysis produces "safe" approximations of the computations that can occur for a program. The method has since been used as the basis for analysis work also in both functional and logic programming languages.
A theoretic area of current importance is that of designing operators for transformation of domains, and the algebraic understanding of abstract interpretation, as for instance covered by Giacobazzi and Scozzari in "A Logical Model for Relational Abstract Domains", ACM tr. on. Prog. Lang. and Sys. sep 1998, v.20. no. 5 pp 1067--1109.
Applications of abstract interpretation include providing information to a compiler which helps it to produce better code, e.g. for compile-time garbage collection or as a tool for a programmer checking whether the program is at risk of producing unexpected data or reaching unexpected states.
An analyser based on abstract interpretation has a fixpoint solver and a set of domain functions as central components.
There are also approaches where the analysis is transformed into a constraint problem.
A bibliography on abstract interpretation for logic programming is handled by Marc-Michel Corsini at LaBri, Bordeaux, France.
Semantics-Based Program Analysis and Manipulation gives pointers to several analysis projects world-wide.
The Program Analysis and Verification Group at Stanford works on modelling true concurrency with another approach.
At SICS we have designed and implemented different experimental analysis programs for types and aliases in logic programs and AKL programs. All of these, and some variants that are not yet implemented, are described, and soundness of the major ones is proven, in my forthcoming thesis. (The variants are all motivated by a wish to achieve more precise analysis covering polymorphism, abstract entailment as well as other domains than types and aliases. There is also a simpler analysis scheme for sequential logic programs).
A precondition analyser for AKL using generic fixpoint solvers is part of the downloadable Agents/AKL release.
The analyser generates a fixpoint problem over a domain expressing possible aliases and types at program points. It makes use of program points at guards, bodies and literals and uses general fixpoint solvers to solve the generated equation system. The motivation for the method goes through a step of first devising an abstracted version of the operational semantics of AKL (a variant of the computation rules showing the possible executions of AKL in the form given by the original designers) and relating this to the schema that generates the fixpoint problem. Three different versions of the fixpoint solver were tested. The implementation of the analyser was originally in AKL. Later it has also been automatically translated to Prolog giving a more efficient system; appr. 4 times faster and much more lean in its memory requirements (since the analyser is essentially a deterministic algorithm capable of making use of the highly efficient SICStus Prolog compiler). The AKL analyser has been applied to all demo programs of AKL proving its applicability on programs up to several thousand lines of AKL code.
ParForce, ESPRIT Project in which the initial design and implementation activity (except formal proofs and refinements) was performed.
A poster on our analysis system.
A bottom-up algorithm based on abstracting unification of terms with set membership for abstract terms and using an obvious fixpoint algorithm to collect all possible equalities in the program.
A rewrite algorithm collecting all equalities occurring in a normalized program and adding transition relations modeling the argument transfer occuring in calls, and then normalizing the set of equations based on this information.
Another algorithm based on specialising clauses for possible calls as the analysis proceeds, giving a form of polymorphism, since different variant of the program clauses generated for different calls are given different types. (based on an initial idea by Torkel Franzén).
Sound and efficient analysis of the CCP Language AKL. Thomas Sjöland. In Dagstuhl Seminar on Concurrent Constraint Programming - The Next Ten Years. Schloss Dagstuhl, Germany, Oct 1997. Vijay Saraswat et.al. (org.). Slides.
Sound and efficient analysis of the CCP Language AKL - the quick story. Thomas Sjöland. In Seminar on Programming Language Implementation. Teleinformatik, KTH, Stockholm, 30 Sep 1997. Björn Lisper (org.). Slides.
A Domain Independent Framework for the Analysis of AKL. Per Brand and Thomas Sjöland. Extended Abstract in Fifth Compulog Network Area Meeting on Language Design and Analysis Methods. , Giorgio Levi and Maurizio Gabrielli (eds.). Università di Pisa, 1996. Slides.
Efficient Analysis of Type and Alias Information for a Concurrent Constraint Language. (Per Brand, Dan Sahlin, Erik Schön and Thomas Sjöland). Presentation in Analysis and Verification of Multiple-Agent Languages. Fifth LOMAPS Workshop. Abstracts. , Mads Dam and Fredrik Orava (eds.). SICS Research Report R96:05. Slides from the presentation.
ParForce deliverable D.WP2.3.5.M3: Assessment of a Storage Optimization Tool for AKL. Per Brand, Dan Sahlin and Thomas Sjöland. Slides on the assessment of our analysis system.
ParForce deliverable D.WP2.1.3.M3:On the Computation of Fixpoint in Static Program Analysis with an Application to Analysis of AKL. Erik Schön. (Master's thesis, KTH).
Fixpoint Analysis of Types and Alias in AKL Programs (w. D. Sahlin), (abstract).
SICS report R94/13b. (final update 950628 of deliverable D.WP1.6.1.M2 in ParForce).


Marco Polo V3 | Phone Finder APK Latest Download For PC Windows Full Version.Marco Polo V3 | Phone Finder APK Apps Full Version Download for PC.Download Marco Polo V3 | Phone Finder APK Latest Version for PC,Laptop,Windows.*Note this app may not be compatible with your device, we apologize for the let-down, we're endeavoring to make Marco Polo work on all devices.
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Thirsty Monk opened its 12 barrel brewery in Denver's Uptown, City Park West neighborhood in 2017. Join us in our comfortable taproom, or out on the patio, and enjoy our tap list of award-winning Belgian Rooted Modern Ales, along with expertly paired food flights and burgers! Check out weekly beer and food specials, including Happy Hour from Monday through Friday, 4 pm to 6 pm.


text:
Trippie Redd Responds To Eminem's "Music To Be Murdered By" Mention
Big Melly
. Jan 23, 2020
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On his recent album "Music To Be Murdered By", Eminem took a few shots at some chosen rappers but compared to his 2018 LP "Kamikaze", he went relatively light on people. Em aired out Machine Gun Kelly, Joe Budden and Trippie Redd on the track "Marsh".
Then he said kill MCs/Trippie Redd, with pills and lean/Sipping meds in the limousine/Getting head, guillotine.
Now, Trippie Redd is responding to Eminem's attack on one of his Instagram stories.
Niggas be 50 beefing wit a 15yr old.
His reply was followed by a peace sign emoji and sleepy face emoji, indicating that the youngster is tired of the drama.
Joe Budden also responded to Slim Shady during a recent episode of The Joe Budden Podcast. People assumed that Eminem's line on the track "I Will" is about Budden, "Your group is off the chain, but you're the weakest link." On the track Em reunites Slaugherhouse members Joell Ortiz, Royce Da 5'9 and KXNG Crooked with Budden being missing.
According to Budden, the line is actually about Lord Jamar, another one of Em's foes.
The Em line in that song, when he was tearing Lord Jamar's ass up on old group flips, that led to 'Your group is off the chain, but you're the weakest link.' In a song featuring [members of] Slaughterhouse, I could see how that looked like it was about Joe. That's about Lord Jamar, obviously, if you listen to the eight bars coming before it. You [listeners can] get your panties out the bunch.
Budden concluded,
The same way I feel like [Eminem] should stop dissing Lord Jamar, he should stop dissing me. [Laughs] Hey, whatever we had — that exchange when you did all the [multi-day interview segments with Sway Calloway], and whenever I said whatever I said on the pod', it a moment in time.
We had our exchange. It's over. In 2020, I can't harbor negativity not only towards one of the best rappers, but somebody I'm not angry at. That's what I gotta stop doin'. I don't be mad at the people I come in and kill. There's no hostility after that.
Average: 3 / 5. Total Votes: 111
Tags:Beef, Diss, Eminem, Feud, Joe Budden, Music To Be Murdered By, Trippie Redd
Juice Wrld's Cause Of Death Revealed
Megan Thee Stallion - B.I.T.C.H
Quavo To Perform TakeOff Tribute At 2023 Grammy Awards
By Jay Spitty
Trippie Redd Says Hackers Demanded $1 Million Ransom For His Music
Dr. Dre's Debut Album "The Chronic" Re-Released On Streaming Services
Lil Wayne Announces 28-City "Welcome To Tha Carter Tour"
Burna Boy Releases New Music Video "Common Person"
Lil Yachty Drops Bizarre Music Video For "Say Something"
Ice Spice Shares "in ha mood" Music Video


text:
Sorin Frunzăverde (ur. 26 kwietnia 1960 w m. Bocșa, zm. 3 listopada 2019 w m. Reșița) – rumuński samorządowiec, ekonomista i polityk, minister w kilku rządach, w latach 2007–2008 poseł do Parlamentu Europejskiego.

Życiorys
Ukończył studia w Instytucie Politechnicznym w Bukareszcie. Uzyskał również doktorat z zakresu ekonomii. Od 1985 pracował jako inżynier, od 1991 zajmował kierownicze stanowiska w przedsiębiorstwach. W 1992 po raz pierwszy został radnym okręgowym.

Pełnił szereg funkcji rządowych. Od grudnia 1997 do lutego 1998 był ministrem gospodarki wodnej, leśnictwa i ochrony środowiska w gabinecie Victora Ciorbea, od kwietnia do grudnia 1998 zajmował stanowisko ministra turystyki w rządzie Radu Vasile. Dwukrotnie sprawował urząd ministra obrony narodowej: od marca do grudnia 2000 u premiera Mugura Isărescu oraz od października 2006 do kwietnia 2007 u premiera Călina Popescu-Tăriceanu.

W latach 1996–1997, 1998–2000 i 2004–2006 był przewodniczącym rady okręgu Caraș-Severin. Od 2000 do 2004 zasiadał w Izbie Deputowanych.

W grudniu 2007 z ramienia Partii Demokratycznej uzyskał mandat posła do Parlamentu Europejskiego. Był członkiem grupy chadeckiej, Komisji Spraw Zagranicznych oraz Podkomisji Bezpieczeństwa i Obrony. W 2008 został członkiem Partii Demokratyczno-Liberalnej, współtworzonej przez swoje dotychczasowe ugrupowanie.

Z PE odszedł w czerwcu 2008 w związku z ponownym objęciem urzędu przewodniczącego rady okręgu Caraș-Severin, pełnił tę funkcję także po kolejnych wyborach do 2016. Od 2012 działał w Partii Narodowo-Liberalnej. W 2016 został skazany na karę pozbawienia wolności z warunkowym zawieszeniem jej wykonania za przestępstwo przeciwko wyborom.

Przypisy

Bibliografia

Politycy Partii Demokratyczno-Liberalnej
Politycy Partii Narodowo-Liberalnej (Rumunia)
Rumuńscy ministrowie obrony
Rumuńscy posłowie do Izby Deputowanych
Rumuńscy posłowie do Parlamentu Europejskiego
Rumuńscy samorządowcy
Urodzeni w 1960
Zmarli w 2019


Kraft Foods Group Inc (NASDAQ:KRFT), which is merging with ketchup maker H.J. Heinz Co, on Wednesday reported profit that topped analyst estimates, driven by reduced advertising spending and overhead.
But the company missed revenue expectations amid sluggish demand for its meals and desserts. Kraft, whose brands include Velveeta and Oscar Mayer, is struggling to grow as consumers shift to brands that are perceived as healthier, including foods that are organic or less processed.
Shares fell 1 percent to $85.01 in after-hours trading on Wednesday.
Kraft's net income fell 16 percent to $429 million, or 72 cents per share, in the first quarter ended March 28 from $513 million, or 85 cents per share, a year earlier. When adjusted for items such as cost cuts and a loss related to post-employment benefit plans, the company earned 86 cents a share.
Revenue fell slightly to $4.35 billion. Analysts had expected earnings per share of 81 cents and revenue of $4.43 billion.
Heinz, backed by Warren Buffett's Berkshire Hathaway Inc and Brazilian private equity firm 3G Capital, will combine with Kraft to create the third-largest North American food company, the companies said in late March.
Both companies said at the time that the deal, which is expected to close in the second half of 2015, would provide an opportunity to expand Kraft's brands overseas.
In the first quarter, the company said it benefited from price hikes in the past year, as well as increases in sales by its cheese and refrigerated meals businesses, which rose 1.3 percent and 2.1 percent, respectively.


Abstract : This paper is concerned by the statistical analysis of data sets whose elements are random histograms. For the purpose of learning principal modes of variation from such data, we consider the issue of computing the PCA of histograms with respect to the 2-Wasserstein distance between probability measures. To this end, we propose to compare the methods of log-PCA and geodesic PCA in the Wasserstein space as introduced by Bigot et al. (2015) and Seguy and Cuturi (2015). Geodesic PCA involves solving a non-convex optimization problem. To solve it approximately, we propose a novel forward-backward algorithm. This allows a detailed comparison between log-PCA and geodesic PCA of one-dimensional histograms, which we carry out using various data sets, and stress the benefits and drawbacks of each method. We extend these results for two-dimensional data and compare both methods in that setting.