Increasing Utilization and Excellent Initial Outcomes Following Liver Transplant of HCV-Viremic Donors into HCV-Negative Recipients.
Hepatology. 2019 Jan 31. doi: 10.1002/hep.30540.
Hepatology. 2019 Jan 11. doi: 10.1002/hep.30501.
The burden of chronic hepatitis C in China from 2004 to 2050: an individual-based modeling study.
Hepatology. 2018 Dec 18. doi: 10.1002/hep.30476.
Estimating Prevalence of Hepatitis C Virus Infection in the United States, 2013-2016.
Hepatology. 2018 Nov 6. doi: 10.1002/hep.30297.
New highly diverse hepatitis C strains detected in sub-Saharan Africa have unknown susceptibility to direct-acting antiviral treatments.
Hepatology. 2018 Nov 2. doi: 10.1002/hep.30342.
Impact of all-oral direct-acting antivirals on clinical and economic outcomes in chronic hepatitis C patients in the U.S.
Hepatology. 2018 Oct 5. doi: 10.1002/hep.30303.
(Mid)West Side Story: Acute Hepatitis C Virus Infection and the Opioid Epidemic in the United States.
Hepatology. 2018 Sep 25. doi: 10.1002/hep.30290.
A novel lncRNA regulates HCV infection through IFI6.
Hepatology. 2018 Sep 10. doi: 10.1002/hep.30266.
Direct acting antivirals for patients without advanced liver disease: All for treatment and treatment for all?
Parsing the guidelines on guidelines: Balancing sensibility and conflict of interest.
Hepatology. 2018 Aug 19. doi: 10.1002/hep.30225.
Hepatitis C virus manipulates humans as its favorite host for long term relationship.
Hepatology. 2018 Aug 13. doi: 10.1002/hep.30214.
Safety and Efficacy of Ledipasvir-Sofosbuvir With or Without Ribavirin for Chronic Hepatitis C in Children Ages 6-11.
Hepatology. 2018 Aug 2. doi: 10.1002/hep.30123.
Negative regulation of MAVS-mediated antiviral signaling by the mitochondrial protein LRPPRC during HCV infection.
Hepatology. 2018 Aug 2. doi: 10.1002/hep.30149.
Transplanting Hepatitis C seropositive, nucleic acid test negative donor organs into hepatitis C negative recipients.
Hepatology. 2018 Aug 2. doi: 10.1002/hep.30121.
Revisiting the Paradox of ISG expression as a predictor of HCV treatment response, a decade later.
Hepatology. 2018 Jul 28. doi: 10.1002/hep.30195.
Has Access to HCV Therapy Changed for Patients with Mental Health or Substance Use Disorders in the DAA Period?
Hepatology. 2018 Jul 17. doi: 10.1002/hep.30171.
Successful treatment with Harvoni((R)) in an ADA-SCID infant with HCV infection allowed gene therapy with Strimvelis((R)).
Hepatology. 2018 Jul 16. doi: 10.1002/hep.30160.
Transplantation of Livers from Viremic HCV Positive Donors into HCV Negative Recipients.
Hepatology. 2018 Jun 11. doi: 10.1002/hep.30106.
Pay It Forward: Building Capacity to Treat Hepatitis C by Training Our Own Residents.
Hepatology. 2018 May 23. doi: 10.1002/hep.30101.
Binding of Free and Immune Complex-Associated Hepatitis C Virus to Erythrocytes Is Mediated by the Complement System.
Hepatology. 2018 May 9. doi: 10.1002/hep.30087.
CD2-associated Protein Contributes to Hepatitis C Virus Propagation and Steatosis by Disrupting Insulin Signaling.
Hepatology. 2018 May 5. doi: 10.1002/hep.30073.
Baseline Intrahepatic and Peripheral Innate Immunity are Associated with Hepatitis C Virus Clearance During DAA Therapy.
Hepatology. 2018 Apr 27. doi: 10.1002/hep.29921.
Expanding Donor Pool for Liver Transplantation by Utilizing Hepatitis C Virus-Infected Donors for Uninfected Recipients.
Hepatology. 2018 Apr 19. doi: 10.1002/hep.30043.
Hepatitis C in Patients with Renal Disease: A Deeper Dive into the KDIGO Guideline.
Hepatology. 2018 Apr 19. doi: 10.1002/hep.30047.
Hepatology. 2018 Apr 19. doi: 10.1002/hep.30046.
Reply to Expanding Donor Pool for Liver Transplantation by Utilizing Hepatitis C Virus-Infected Donors for Uninfected Recipients.
Hepatology. 2018 Apr 19. doi: 10.1002/hep.30042.
Impact of IFNL4 genotype on Interferon-stimulated Gene Expression during DAA therapy for Hepatitis C.
Hepatology. 2018 Mar 13. doi: 10.1002/hep.29877.
Hepatitis C virus E2 envelope glycoprotein induces an immunoregulatory phenotype in macrophages.
Hepatology. 2018 Feb 14. doi: 10.1002/hep.29843.
NS5A-P32 deletion after failure of ledipasvir/sofosbuvir in hepatitis C virus genotype 1b infection.
Hepatology. 2018 Feb 9. doi: 10.1002/hep.29836.
Resistance analysis of genotype 3 HCV indicates subtypes inherently resistant to NS5A inhibitors.
Hepatology. 2018 Feb 9. doi: 10.1002/hep.29837.
Response to Treatment of Acute HCV Cost-Effective but at What Price?
Hepatology. 2018 Jan 5. doi: 10.1002/hep.29770.
Treatment of Acute HCV Cost-Effective but at What Price?
Hepatology. 2018 Jan 5. doi: 10.1002/hep.29771.
Of mice, rats and men: Small animal model of hepatitis C virus infection.
Hepatology. 2017 Dec 27. doi: 10.1002/hep.29765.
Transplanting HCV-positive livers into HCV-negative patients with preemptive antiviral treatment: A modeling study.
Hepatology. 2017 Dec 9. doi: 10.1002/hep.29723.
Hepatitis C Transmission from Seropositive, Non-Viremic Donors to Non-Hepatitis C Liver Transplant Recipients.
Hepatology. 2017 Dec 2. doi: 10.1002/hep.29704.
The short-term incidence of hepatocellular carcinoma is not increased after hepatitis C treatment with direct-acting antivirals: An ERCHIVES study.
Hepatology. 2017 Dec 2. doi: 10.1002/hep.29707.
Lower effectiveness of hepatitis C antiviral treatment in patients with hepatocellular carcinoma: Is active tumor the clue?
Hepatology. 2017 Dec 1. doi: 10.1002/hep.29700.
Hepatocellular carcinoma decreases the effectiveness of hepatitis C antiviral treatment: does direct-acting antiviral regimens matter?
Hepatology. 2017 Dec 1. doi: 10.1002/hep.29701.
Impact of Hepatitis C Virus Polymorphisms on Direct-Acting Antiviral Treatment Efficacy: Regulatory Analyses and Perspectives.
Hepatology. 2017 Dec 1. doi: 10.1002/hep.29693.
Towards the Elimination of Hepatitis C in the United States.
Hepatology. 2017 Nov 27. doi: 10.1002/hep.29685.
Glecaprevir/Pibrentasvir in Patients with HCV Genotype 1 or 4 and Prior Direct-acting Antiviral Treatment Failure.
Hepatology. 2017 Nov 20. doi: 10.1002/hep.29671.
Sofosbuvir, Peg Interferon & Ribavirin for retreatment of HCV genotype 1b following Sofosbuvir and Ledipasvir failure.
Hepatology. 2017 Nov 20. doi: 10.1002/hep.29667.
Hepatitis C and Human Immunodeficiency Virus Co-Infection in the Era of Direct-Acting Antiviral Agents: No Longer A Difficult to Treat Population.
Hepatology. 2017 Nov 6. doi: 10.1002/hep.29642.
Hepatitis B reactivation in chronic hepatitis C patients treated with interferon or pan-oral direct-acting antivirals.
Hepatology. 2017 Oct 28. doi: 10.1002/hep.29620.
Benefit-Risk Assessment for Sofosbuvir/Velpatasvir/Voxilaprevir Based on Patient Population and HCV genotype: FDA's Evaluation.
Hepatology. 2017 Oct 23. doi: 10.1002/hep.29601.
Should we treat acute hepatitis C? A decision and cost-effectiveness analysis.
Hepatology. 2017 Oct 23. doi: 10.1002/hep.29611.
The Efficacy of New Anti-Viral Regimens for Hepatitis C Infection: Evidence from A Systematic Review.
Hepatology. 2017 Oct 10. doi: 10.1002/hep.29580.
The Rise of the Opioid Epidemic and Hepatitis C Positive Organs: A New Era in Liver Transplantation.
Hepatology. 2017 Oct 10. doi: 10.1002/hep.29572.
Acquired hemophilia A resolution in an HCV/HIV coinfected patient with cure of hepatitis C by direct antiviral agents.
Hepatology. 2017 Sep 28. doi: 10.1002/hep.29560.
OATP1B1 and DAA treatment for hepatitis C in patients with hepatocellular carcinoma.
Hepatology. 2017 Sep 27. doi: 10.1002/hep.29556.
Equitable Access to All-Oral Direct-Acting Antiviral Therapy is a Mandatory Step to Achieve Global Hepatitis C Virus Eradication.
Hepatology. 2017 Sep 27. doi: 10.1002/hep.29555.
Societal perspectives' analysis for evaluating direct-acting antivirals affordability while awaiting liver transplant.
Hepatology. 2017 Sep 27. doi: 10.1002/hep.29558.
Hepatitis C Virus Testing for Case Identification in Persons Born during 1945-1965: Results from Three Randomized Controlled Trials.
Hepatology. 2017 Sep 23. doi: 10.1002/hep.29548.
Late hepatitis B reactivation following DAA-based treatment of recurrent hepatitis C in an anti-HBc-positive liver transplant recipient.
Hepatology. 2017 Sep 16. doi: 10.1002/hep.29528.
Human Leukocyte Antigen Variants and Risk of Hepatocellular Carcinoma Modified by HCV Genotypes: A Genome-wide Association Study.
Hepatology. 2017 Sep 16. doi: 10.1002/hep.29531.
Chronic Hepatitis C Increases the Risk of Chronic Kidney Disease (CKD) while Effective HCV Treatment Decreases the Incidence of CKD.
Hepatology. 2017 Sep 5. doi: 10.1002/hep.29505.
Efficacy and Safety of Glecaprevir/Pibrentasvir in Japanese Patients with Chronic Genotype 2 Hepatitis C Virus Infection.
Hepatology. 2017 Sep 2. doi: 10.1002/hep.29510.
Viral persistence, liver disease and host response in Hepatitis C-like virus rat model.
Hepatology. 2017 Aug 31. doi: 10.1002/hep.29494.
Engaging hepatitis C infected patients in cost-effectiveness analyses: A literature review.
Hepatology. 2017 Aug 23. doi: 10.1002/hep.29482.
The contribution of health risk behaviours to excess mortality in American adults with chronic hepatitis C: A population cohort-study.
Hepatology. 2017 Aug 4. doi: 10.1002/hep.29419.
HCV and non-hepatic malignancy: Is pre-emptive DAA therapy indicated prior to treatment?
Hepatology. 2017 Aug 2. doi: 10.1002/hep.29414.
Hepatocyte-derived exosomes promote T follicular regulatory cell expansion during HCV infection.
Hepatology. 2017 Jul 27. doi: 10.1002/hep.29409.
Modelling cost-effectiveness and health gains of a "universal" vs. "prioritized" HCV treatment policy in a real-life cohort.
Hepatology. 2017 Jul 24. doi: 10.1002/hep.29399.
Impact of an Electronic Health Record Alert in Primary Care on Increasing Hepatitis C Screening and Curative Treatment for Baby Boomers.
Hepatology. 2017 Jul 17. doi: 10.1002/hep.29362.
Efficacy and safety of new direct antiviral agents in HCV infected patients with Diffuse Large B Cell Non-Hodgkin Lymphoma.
Hepatology. 2017 Jul 17. doi: 10.1002/hep.29364.
Hepatology. 2017 Jul 17. doi: 10.1002/hep.29361.
Comments on Cochrane Review on Direct-Acting Antivirals for Hepatitis C.
Hepatology. 2017 Jul 16. doi: 10.1002/hep.29366.
Grazoprevir, Ruzasvir, and Uprifosbuvir for HCV After NS5A Treatment Failure.
Hepatology. 2017 Jul 7. doi: 10.1002/hep.29358.
Hepatitis C virus induced tumor initiating cancer stem-like cells activate stromal fibroblasts in xenograft tumor model.
Hepatology. 2017 Jun 30. doi: 10.1002/hep.29346.
Hepatitis C virus reactivation in patients receiving cancer treatment: A prospective observational study.
Hepatology. 2017 Jun 27. doi: 10.1002/hep.29344.
Kidney transplant recipients with Hepatitis C virus experienced 100% SVR12 rate when treated with sofosbuvir-ledipasvir.
Hepatology. 2017 Jun 26. doi: 10.1002/hep.29339.
High Hepatitis C cure rates among black and non-black HIV-infected adults in an urban center.
Hepatology. 2017 Jun 13. doi: 10.1002/hep.29308.
Response to Optimal Timing for Hepatitis C Antiviral Therapy in the Peri-Transplant Period?
Hepatology. 2017 Jun 6. doi: 10.1002/hep.29299.
Optimal Timing for Hepatitis C Antiviral Therapy in the Peri-Transplant Period?
Hepatology. 2017 Jun 6. doi: 10.1002/hep.29300.
Sofosbuvir and Ribavirin in Adolescents 12 to 17 Years Old With Hepatitis C Virus Genotype 2 or 3 Infection.
Hepatology. 2017 May 22. doi: 10.1002/hep.29278.
Safety and Efficacy of Current DAA Regimens in Kidney and Liver Transplant Recipients with Hepatitis C: Results from the HCV-TARGET Study.
Hepatology. 2017 May 15. doi: 10.1002/hep.29258.
Sofosbuvir-velpatasvir with ribavirin for 24 weeks in HCV patients previously treated with a direct-acting antiviral regimen.
Hepatology. 2017 May 12. doi: 10.1002/hep.29256.
Hepatic steatosis, hepatitis C and human immunodeficiency viruses: A complex interplay.
Hepatology. 2017 Apr 19. doi: 10.1002/hep.29218.
Efficient replication of blood borne Hepatitis C Virus in human fetal liver stem cells.
Hepatology. 2017 Apr 13. doi: 10.1002/hep.29211.
Persisting risk of hepatocellular carcinoma after HCV cure monitored by a liver transcriptome signature.
Hepatology. 2017 Apr 8. doi: 10.1002/hep.29203.
Direct-acting Antivirals during or after Immuno-chemotherapy in Hepatitis C Virus-positive Diffuse Large B-cell Lymphomas.
Hepatology. 2017 Apr 5. doi: 10.1002/hep.29198.
Hepatitis C Viral Load, Genotype, and Increased Risk of Developing End-stage Renal Disease: REVEAL-HCV Study.
Hepatology. 2017 Apr 2. doi: 10.1002/hep.29192.
HBV Reactivation During DAA Treatment of Chronic Hepatitis C: A Hidden Danger of an Otherwise Major Success Story.
Hepatology. 2017 Mar 30. doi: 10.1002/hep.29185.
Unexpected viral relapses in HCV-infected patients diagnosed with hepatocellular carcinoma during treatment with DAAs.
Hepatology. 2017 Mar 30. doi: 10.1002/hep.29181.
Ginsenoside Rg3 Restores Hepatitis C Virus-Induced Aberrant Mitochondrial Dynamics and Inhibits Virus Propagation.
Hepatology. 2017 Mar 22. doi: 10.1002/hep.29177.
Hepatitis C virus induced CCL5 secretion from macrophages activates hepatic stellate cells.
Hepatology. 2017 Mar 20. doi: 10.1002/hep.29170.
Immune phenotype and function of NK and T cells in chronic hepatitis C patients who received a single dose of anti-miR-122, RG-101.
Hepatology. 2017 Mar 11. doi: 10.1002/hep.29148.
Elbasvir/Grazoprevir for Patients With Hepatitis C Virus Infection and Inherited Blood Disorders: A Phase III Study.
Hepatology. 2017 Mar 3. doi: 10.1002/hep.29139.
Treatment of Patients Waitlisted for Liver Transplant with an All-Oral DAAs is a Cost-Effective Treatment Strategy in the United States.
Hepatology. 2017 Mar 3. doi: 10.1002/hep.29137.
Hepatology. 2017 Feb 27. doi: 10.1002/hep.29135.
Human ES Cell-derived Hepatoblasts are an Optimal Lineage Stage for HCV Infection.
Hepatology. 2017 Feb 25. doi: 10.1002/hep.29134.
Sofosbuvir-velpatasvir-voxilaprevir with or without ribavirin in DAA-experienced patients with genotype 1 HCV.
Hepatology. 2017 Feb 21. doi: 10.1002/hep.29130.
Development of proteinuria and focal segmental glomerulosclerosis during direct acting antiviral therapy for hepatitis C virus infection (HEP-16-2474.R1).
Hepatology. 2017 Feb 17. doi: 10.1002/hep.29125.
Challenges in Treatment of Hepatitis C among Patients with Hepatocellular Carcinoma.
Hepatology. 2017 Feb 17. doi: 10.1002/hep.29126.
Hepatitis B reactivation in hepatitis B and C coinfected patients treated with antiviral agents: A systematic review and meta-analysis.
Hepatology. 2017 Feb 13. doi: 10.1002/hep.29109.
A master regulator of tight junctions involved in hepatitis C virus entry and pathogenesis.
Hepatology. 2017 Feb 8. doi: 10.1002/hep.29066.
Overcoming Injustice: A Roadmap to Improve Access to HCV Therapy for Our Medicaid Patients.
Hepatology. 2017 Feb 4. doi: 10.1002/hep.29095.
Apolipoprotein(a) Inhibits Hepatitis C Virus Entry Through Interaction With Infectious Particles.
Hepatology. 2017 Feb 2. doi: 10.1002/hep.29096.
Glecaprevir and Pibrentasvir for 12 Weeks for HCV Genotype 1 Infection and Prior Direct-acting Antiviral Treatment.
Hepatology. 2017 Jan 27. doi: 10.1002/hep.29081.
Eradication of HCV and non-liver-related non-AIDS-related events in HIV/HCV coinfection.
Hepatology. 2017 Jan 21. doi: 10.1002/hep.29071.
Reply to "Addressing opioid use disorder in modeling hepatitis C transmission among persons who inject drugs".
Hepatology. 2017 Jan 21. doi: 10.1002/hep.29069.
Addressing opioid use disorder in modeling hepatitis C transmission among persons who inject drugs.
Hepatology. 2017 Jan 21. doi: 10.1002/hep.29070.
Race or Genetic Makeup for HCV Treatment Decisions?
Hepatology. 2017 Jan 18. doi: 10.1002/hep.29057.
Reply to: Race or Genetic Makeup for HCV Treatment Decisions?
Hepatology. 2017 Jan 18. doi: 10.1002/hep.29058.
The Dynamic Landscape of Liver Transplant in the Era of Effective HCV Therapy.
Hepatology. 2017 Jan 17. doi: 10.1002/hep.29054.
NS5B Promotes Degradation of the NORE1A Tumor Suppressor to Facilitate Hepatitis C Virus Replication.
Hepatology. 2017 Jan 16. doi: 10.1002/hep.29049.
LGP2 plays an essential role in HCV infection-induced interferon responses.
Hepatology. 2017 Jan 16. doi: 10.1002/hep.29050.
Eight weeks of Ledipasvir/Sofosbuvir is effective for selected patients with genotype 1 Hepatitis C virus infection.
Hepatology. 2016 Dec 27. doi: 10.1002/hep.29005.
Hepatology. 2016 Dec 20. doi: 10.1002/hep.28989.
The Safety and Effectiveness of Ledipasvir-Sofosbuvir in Adolescents 12 to 17 Years Old With Hepatitis C Virus Genotype 1 Infection.
Hepatology. 2016 Dec 20. doi: 10.1002/hep.28995.
HIV-infected and Uninfected Adults with Non-Genotype 3 Hepatitis C Virus Have Less Hepatic Steatosis than Adults with Neither Infection.
Hepatology. 2016 Dec 16. doi: 10.1002/hep.28968.
Persistent HCV-associated Cryoglobulinemic Vasculitis Following Virus Eradication after Direct-Acting Antivirals Therapy.
Hepatology. 2016 Dec 10. doi: 10.1002/hep.28981.
Hepatitis C virus infection triggers a tumor-like glutamine metabolism.
Hepatology. 2016 Nov 18. doi: 10.1002/hep.28949.
Optimal Timing of Hepatitis C Treatment for Patients on the Liver Transplant Waiting List.
Hepatology. 2016 Nov 5. doi: 10.1002/hep.28926.
Farnesoid X receptor ablation sensitizes mice to hepatitis b virus X protein-induced hepatocarcinogenesis.
Hepatology. 2016 Nov 5. doi: 10.1002/hep.28924.
Reduction in liver transplant wait-listing in the era of direct-acting antiviral therapy.
Hepatology. 2016 Nov 5. doi: 10.1002/hep.28923.
The association between race/ethnicity and the effectiveness of direct antiviral agents for hepatitis C virus infection.
Hepatology. 2016 Oct 24. doi: 10.1002/hep.28901.
Short-duration Treatment With Elbasvir/Grazoprevir and Sofosbuvir for Hepatitis C: A Randomized Trial.
Hepatology. 2016 Oct 22. doi: 10.1002/hep.28877.
Uptake of Hepatitis C Screening, Characteristics of Patients Tested, and Intervention Costs in the BEST-C Study.
Hepatology. 2016 Oct 22. doi: 10.1002/hep.28880.
Hepatitis C virus double-stranded RNA is the predominant form in human liver and in interferon-treated cells.
Hepatology. 2016 Sep 19. doi: 10.1002/hep.28846.
Preferential Association of Hepatitis C Virus with CD19+ B Cells Is Mediated by Complement System.
Hepatology. 2016 Sep 19. doi: 10.1002/hep.28842.
Affinity maturation of a broadly neutralizing human monoclonal antibody that prevents acute HCV infection.
Hepatology. 2016 Sep 19. doi: 10.1002/hep.28850.
"Hep C, where art thou": What are the remaining (fundable) questions in HCV research?
Hepatology. 2016 Sep 19. doi: 10.1002/hep.28848.
CD14+ monocyte-derived Galectin-9 induces NK cell cytotoxicity in chronic hepatitis C.
Hepatology. 2016 Sep 19. doi: 10.1002/hep.28847.
Hepatology. 2016 Sep 17. doi: 10.1002/hep.28844.
Emerging complexities with HCV DAA regimens: Less is still way more.
Hepatology. 2016 Sep 16. doi: 10.1002/hep.28832.
Hepatology. 2015 Dec 5. doi: 10.1002/hep.28380.


text:
Reappointment of National Gallery of Australia Director
Reappointment of National Gallery of…
The Turnbull Government welcomes the reappointment of Dr Gerard Vaughan AM as Director of the National Gallery of Australia (NGA).
Dr Vaughan, a distinguished public gallery director and internationally recognised scholar, was first appointed to the role in 2014. His leadership, professional experience and diplomacy have delivered strong outcomes for the NGA, including renewed public access to the Gallery's collections and prominence to the Australian Collections, a continued program of major international exhibitions and partnerships, and a robust program of provenance research.
Dr Vaughan has also explored new philanthropic avenues and fundraising practices to cultivate private and public sector support for the Gallery.
Prior to working at the NGA, Dr Vaughan was the Director of the National Gallery of Victoria and the Director of the British Museum Development Trust in London.
Dr Vaughan is also Deputy Chair of the Australian Institute of Art History at The University of Melbourne.
Dr Vaughan's dedication and commitment will continue to drive the Gallery's work throughout his second term, which will end in October 2018.
The NGA holds the national art collection of Australia, including the largest display of Australian Indigenous art in the world.
For more information about the NGA visit: www.nga.gov.au
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redpajama_set_name: RedPajamaCommonCrawl


text:
All of Us with Wings: Review
Posted on February 28, 2019 by theworldofceliamcmahon
Once in a while, a book comes along that completely blows my mind. This is one of those books.
Thank you to Edelweiss and the publisher for allowing me to review this book ahead of its release date.
What is it about, you ask?
Our 17-year old protagonist is named Xochi. She's a governess to a 12-year old girl named Pallas. Pallas is our second POV, and she lives in a grand old house in San Fran with her rock star parents and their colorful array of friends. Xochi has a troubled past that she's running away from, but the further she goes the more she realizes she must do something more than running. One night, on the Equinox, Xochi and Pallas cast what they think is a silly spell that ultimately summons a pair of fey children from their slumber to protect Xochi at all costs. Between Pallas' growing pains and Xochi's painful past, they find themselves in more trouble than they planned. The third POV is from the perspective of a cat named Peasblossom
So, from page one I got serious anime vibes so throughout the entire book I imagined this one of Miyazaki's magical, emotional films. Or better yet, A Letter to Momo which is one of the few movies that seriously made me cry my eyes out. Michelle, Ruiz Keil took me through the lives of these people, and I felt as though I was there with them, feeling their joy and their pain and their confusion. It was well paced and excellently written.
Some things were a bit cringe-worthy, such as Xochi's attraction to Pallas' dad as well as the drug use, BUT I could see how they played into the story intricately. This book is about finding yourself. To do that you must make a ton of mistakes along the way. The environment Xochi found herself in and the life Pallas grew up in, was not the most stable and by the end, I think everyone knew it and strived to make changes.
At times, I was a bit confused about what these weird fey kids were, and maybe I still am. That and the quick ending knocked it down a star for me. But overall this was a beautiful and engaging coming of age story.
I seek out magical realism because they are the most intriguing for me. This book falls into books like Summer of Salt and The Strange and Beautiful Sorrows of Ava Lavender so if you liked those; this book is for you.
Warnings for: drug use, rape (off the page).
Rayne and Delilah's Midnite Matinee: Review
I have come to expect a few things out of a book by Jeff Zentner. One that I will probably cry at some point. Two that I probably won't sleep or eat until I finish. Three, that I will continue to follow this man's career to the end of my days.
This story follows Josie and Delia, hosts of a public access monster movie show. Both are uniquely different but fit together like PB and j. Delia comes from a broken home (her father abandoned her and her mother) whereas Josie comes from one a tad more put together. Delia's story takes a turn into heartbreak city because she yearns to find him. She even hires a private detective despite her mother's financial burdens. Josie struggles with leaving Delia and her sense of responsibility for her friend. Josie also wants to be on television and Delia wants to track down her dad and have closure. Their rival dilemmas may or may not split them apart.
The core of this story centers around their show which, for the first time, was something incredibly new in a YA novel for me. I've read your podcast novels, your theater novels, your Youtube channel novels, but this one was a shiny territory and entertaining AF. More so to the scene-stealing Lawson, an MMA fighter and reader. What a combination. Drools in book nerd.
The split POV's with both girls were fantastic. I think I loved Delia's more since Josie's focused a tab too much on her romance with Lawson for my tastes. Her character did not have emotions as Delia's did. At least for me. But this wasn't a problem because I loved Lawson too much.
This book touches upon mental illness as well as the effects of being abandoned by a parent. I believe a lot of people can relate to this and may even find solidarity in Delia's story. But through all of that, there is humor. I am not the type to laugh at loud at books or even movies. I have a very particular sense of humor. This one had me chuckling and waking up my husband. Score on both accounts. That being said, this had more witty moments than Jeff's other books and reminded me so much of myself and my best friend in high school.
"I get lonely sometimes, but so does everyone else. We're all looking for some sort of salvation in something."
If you loved The Serpent King and Goodbye Days, you will love this one. You may even enjoy it more. You may also follow Jeff on every platform you can and pick apart every tweet looking for news of his next book. I will do that. Always. No shame.
Thank you to Netgalley and the publisher for a chance to review this title ahead of its release date.
The Arrival of Someday: review
Expected publication: July 23rd 2019 by HarperTeen
Thank you to Edelweiss and BIG FAT thanks to HarperCollins for always entrusting me to review their e-arcs.
Let me preface this by telling you all how much of a sucker for punishment I am. I have read, not one, but two books involving fatal diseases and illnesses, but this one…this one took me to a whole new level of sadness, and hope.
This story follows Amelia Linehan, a passionate eighteen-year-old who's into roller derby, drawing, and hanging out with her best friend, Sibby. But behind the scenes, she suffers from a rare liver disorder that could someday affect her life more than it already has. After that someday arrives, she gropes with the growing fear of dying while waiting for a liver transplant. It takes Amelia time to realize her limitations and to grow, even as she and everyone around her, comes to terms that a liver may not come in time.
This is the third book I have read by Jena Malone and by far my favorite. Amelia is a flawed character and not just because of her illness, but because she hasn't quite grown into herself. At eighteen, nobody has, but it seems as though she's been put on the fast track and this causes tension with friends and even family. I loved that the romance did not take center stage for a change and we got to know Amelia without having the distraction of a boyfriend. Also, the roller-derby aspect was entertaining.
The end took me by surprise. I think I'm used to reading books like these and having one thing happen and not the other (I won't say much as not to give anything away) But after reading the author's notes, I see why she ended it the way she did.
All in all, I enjoyed this book. I think I'm going to pick up something a tad more lighthearted before I dissolve into tears.
To anyone wanting to read this or currently reading it, read the author's note, and if you haven't signed up to be an organ donor, please do it. There are several links there to guide you to the right places.
A Curse so Dark and Lonely: Review
I have no clue how I'm supposed to go on and live my life after reading this book? How can you assume I'll be all right? HOW CAN YOU DO THIS TO ME
This book had me hooked from the very first page, and I found myself dragged, forced to feel EMOTIONS that I haven't felt for a long time reading a book. I don't think I blinked. My contacts were dry. My tongue felt like lead in my mouth. I forgot to shower. Days passed, and I did not notice. I was in this story until the very end. AND IT WAS AMAZING.
So, what's it about, you ask?
Harper Lacey finds her world turned on its head when she's suddenly transported to a different world after defending a young woman from her attacker. Her attacker, a guardsman, named Grey takes her to Emberfall (to avoid being knocked out by a tire iron no less). There, Harper meets Prince Rhen who is under a wicked curse. Unable to return home at present, Harper immerses herself, both willingly and unwillingly, into the world around her, and takes charge against those wanting to do Emberfall harm.
But that's the condensed version. There is sooooo much more.
HARPER: She has cerebral palsy, but let me tell you, she does not allow that to define her. Her character is vivacious and determined. She had me mesmerized. Before being kidnapped to Emberfall, she'd been working with her brother to pay off her father's old debts and take care of her cancer-stricken mother. To see her character fear for their lives while playing a role in a different world was heartbreaking. Not only that but to eventually see her torn between responsibilities to both worlds. She has no hesitations to stab and defend herself whenever she deems fit and good for her. YA needs more Harpers.
RHEN: the arrogant prince of Emberfall is no short of charming and dimwitted when it comes to women. Which, I don't know, makes him charming? Meeting Harper was not like meeting all the other girls he'd had brought to his castle to break the curse. He finally met his match.
Ok. Now for my book boyfriend, GREY: Never have I known a secondary character to engage me as much as he did. As Mr. Scary Grey Grumpykins, he is the loyal guard to Rhen. He would literally bleed for his prince. But his softer side shows through in little peeks, and I think that is what got me. I was in love. I didn't plan on falling in love, but here I am.
One of the things I truly loved was that Rhen did not force Harper to do much of anything. By the time Harper arrived, he was so depressed; he thought he'd never break his curse anyhow. There was no Stockholm Syndrome happening as we usually see in retellings of Beauty and the Beast or East of the Sun, West of the Moon. There wasn't much romance at all. What was in there was real and slow burning, so THANK YOU for that.
The end shattered my soul. Although I solved the little secret beforehand, the action that took place before that had me gripping the pages. I was thrust into heartbreak and anger and eventually numbness.
Although this book is long, it didn't feel that way to me, the way I breezed through without providing my body food. Knowing that the next book will have Grey's POV just has me googling ways to transport myself into the future to get my slimy hands on it and waiting is going to be hard. But I shall dream of Grey, and things will be all right.
In closing, this was the best book I have read so far this year.
A Wolf called Wander: Review
Posted on February 5, 2019 by theworldofceliamcmahon
176 pages Expected publication: May 2nd 2019 by Andersen
Genre: Children's/Middle-Grade
A huge thank you to Edelweiss and Andersen for a chance to review this book ahead of its release date.
In this heartfelt and stunning story, we find ourselves seeing life through the eyes of a wolf named Swift. Even as a pup, Swift was as determined as ever to find a place within his pack. Until one day, their pack is attacked by outsides and displaced. Swift finds himself alone. Without the proper tools to survive, he eats small rodents and insects to stay alive. After he's injured, Swift is visited by a raven who helps him along his journey to find food, water, and even other wolves. Coming face to face with adversaries big and small, Swift travels through the land to find where he belongs.
This book is equal parts heartbreaking and equal parts beautiful in so many ways. Not only the wonderful illustrations, but Swift's journey to survive in a world that seems to want to break him. The writing is easy to follow along with and definitely for school-age children. I had no idea this story was based on a real wolf, which made it all the more exciting.
Read this book if you like:
Fluffy wolves
of yea, wolves
The Fever King: Review
376 pages Expected publication: March 1st 2019 by Skyscape
So, I had no idea I needed this book in my life until I began reading up on it, via the author, on Twitter. Chock-full of diversity, and a dystopian society that didn't feel cookie cutter? Sign me up. Sign me the eff up right now.
So, I got this book via Kindle First Reads, and dove right in like a sweaty girl on the Fourth of July. What I noted first was how character driven the book was. I cared for Noam as if he were my son. That was how I knew I had to take care of him. Nothing bad will come to you while mama is here, Noamsy, don't you worry!!! But I am not the author, and bad things do happen to poor Noam. After surviving a viral illness, he wakes up with superpowers and is immediately inducted into an elite academy to begin training. There he meets an array of kids like him, including Dara, who is one of the most troubled and captivating characters I have read in a long time.
What I loved:
This book made me love these characters. I felt their pain, their misery, everything.
The writing was perfection. Enough said there.
The plot was unique.
Diverse cast. (A Jewish, bi, latino? Get out of my diversity dreams)
It crushed my soul into a million pieces.
What I did not like:
How Victoria Lee crushed my soul into a million pieces. But pain is gain. I got this.
On a serious note, this book legit lived up to my expectations. It surpassed them. Shot right out of the sky. I wished the entire series was uploaded to my Kindle right now, Netflix style, but alas I shall suffer with the masses. I mean, this book put me through the wringer, emotionally
justiceforDara
Blood Heir: Review
Thank you to Netgalley for a chance to review this title.
It took me a few days to ponder how I was going to review this title-IF I was going to review it at all seeing as the publication has been ceased. But after reading the acknowledgments after I finished the book, I feel as though the author deserves at least my thoughts on it. Authors put in a crap ton of work into writing a book. This is not to say I will be discounting the voices of others who see parts of this book as problematic. I will be giving light to that as well in as fairly a way as I can.
First, I am putting aside everything and telling you about this story.
This is loosely (LOOSELY) based on the story of Anastasia. This is fantasy world Russia, where certain people have what we call Affinities or special magical powers. Ana is one of those. After being falsely accused of killing her father, the emperor, she runs away and devotes her life to finding the real killer. She stumbles upon a con man named Ramson and convinces him to help her. But Ramson has his secrets, and they may stop Ana from getting to the truth.
Okay, so the writing has minor issues. At some points, it felt like it was trying a bit too hard to make us care for characters. Even without reading the specific issues until after I finished, I did notice some quotes almost directly sounded like they came from somewhere else. It irked me a little, but not enough to let it affect my rating. I think Zao is a talented writer in this aspect and I cannot wait to see what she does in the future.
SPOILER WARNING.
Let's talk about the death of May, the PoC character. As a writer myself and taking out EVERYTHING that everyone else has said, I felt as though her death did not need to happen to advance Ana's arc at all, because it didn't. Ana cried, and it was over. Nothing about May drove Ana to anything other than killing the broker which still didn't have much of an effect on her arc. Sure May saved the other slaves, but they did not even come to play in this book so what was the point? It was pointless. Focusing now on the scene resembling the Rue scene in The Hunger Games, yes, it was a bit too similar for my taste. Mostly for the fact that I cared about Rue and I didn't see enough of May to really care about her. Personally, I was thinking of all the ways that May could have benefited Ana if she were still alive in the series. She could do so much more alive than dead.
I will touch upon this for a minute now: as a writer, you need to be aware of what YOU ARE DOING. You are not just killing a character for dramatic sake. You are killing the only PoC which has been a horrible trend, especially in Hollywood. The token black person, as one would say which was a running joke in horror movies especially. We need to do better. We need to recognize that kids are reading this and they see you. They see this trend that needs to stop. I realize my voice is small and shouldn't even be taken into account. Listen to the PoC's who are telling you (a general "you" since Amelie has already listened) there is a problem. They are loud, whether you choose to listen or not.
I also believe that everybody who had a hand in editing and reading this book needs to also take a step back. There have too many instances of this sort of thing and it needs to stop.
I think I will keep my rating of three stars and see if the book gets edited and rereleased. I will reread it then and edit this review.


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"With Resident Evil 4 being one of the best games in..."
Written on: 10/06/2009 by benleslie5 (5 reviews written)
Beautifully detailed graphics and character animations, Real-time menu system keeps you immersed, Plenty to do once you've beaten it
Merchant from Resident Evil 4 does not return, Frustrating hurdles to leap when joining an online game, Can't swap weapons with a human teammate online, Fans of the series will feel disapointed that there isn't much horror in the game.
With Resident Evil 4 being one of the best games in the series and with a lot of gamers excited about Resident Evil 5 since day 1 back in 2006, a lot of people thought that Resident Evil 5 was going to be great on next-gen consoles ' well you are sort of right and wrong.
Fans of the series will know what I'm talking about with the main story. But for new comers, story isn't that amazing ' mostly funny at certain parts of the game. Ten years after the destruction of Raccoon City, former S.T.A.R.S. Alpha team member Chris Redfield has become an agent of the B.S.A.A. This paramilitary anti-bio-organic weapon organization travels the globe to seek out and destroy Umbrella's creations, which have fallen into the hands of terrorists following the collapse of the multinational pharmaceutical company. When Chris gets a tip off that a known weapons dealer will be making a big deal in the remote African nation of Kijuju, he heads there to put a stop to it and learns what he can about the mysterious doomsday project known only as Uroboros. Chris is joined by Sheva Alomar, a local B.S.A.A. agent, and together they battle wave after wave of infected villagers, horribly mutated monsters, and even Chris's arch-nemesis Albert Wesker.
If you have played through Resident Evil 4 either on the Gamecube or PS2, this should be familiar. It's the same 3rd person controls so you can easily aim for enemies heads unlike on the old Resident Evil games where you can't shoot most of the zombies in the head. Also returning to Resident Evil 5 are quick time events which you have probably seen on other games where you might have to dodge attacks by pressing a random button in certain cut-scenes, so you'll really need to keep your eyes open because you may never know what is going to happen next.
The whole point of Resident Evil 5 is teamwork as you have to watch your partner Sheva, and having a partner can help you blast your way through over 20-30 enemies all at once. There will be times where your partner will be in trouble or badly hurt so you'll have to help her get back on there feet or get enemies off their backs. Throughout Resident Evil 5 you can both only carry a maximum of 9 items each. You can't upgrade it to carry more weapons and items so you will have to choose what you're going to take with you.
At the end of each chapter or if you die you can buy or organize items and weapons but you can also upgrade your weapons as well before jumping back into the game. But the bad news is that the Merchant from Resident Evil 4 does not appear in Resident Evil 5 and a lot of people found him their favourite character in the series.
There is a Co-Operative mode where you can play with a friend online or offline. Players can join in on a free-for-all or invite-only basis if your game session is set up to allow this from the get-go. But with these conveniences, there are some frustrating hurdles that need to be leapt over before a partner can begin playing.
Co-op isn't drop-in, so if someone joins, gameplay is interrupted and immersion is broken to some degree. You can't trade items or weapons with your friends either, so you can't give your friend an upgradeable weapon or mixed herbs.
With Capcom putting a Resident Evil game on next-gen consoles the graphics for Resident Evil 5 are really impressive. But there is more action then in a standard horror game meaning that there isn't much blood, gore and scariness unlike the old Resident Evil games that gave you nightmares.
But there are a lot of detailed environments, like the beginning you start in an African town, then move onto the mines and deserts of Africa and then blast your enemies in a factory facility. But most places in Resident Evil 5 are not scary or creepy and there are no dark places where enemies can come out from the dark and scare you.
There is great voice acting from most of the characters, including the enemies which sound the same as 'Las Ganados' (the villagers in Resident Evil 4). Some enemies return from previous Resident Evil games, such as those who carry a chainsaw and the Lickers from Resident Evil 2 which most gamers will still remember. Music is pretty tense making you feel on the edge of your seat with thrills.
Fans of the series will feel disappointed where some fans thought that zombies were going to return unlike Resident Evil 4 where some people were annoyed that there weren't any zombies. But with the story set in Africa, I thought there would be flesh eating animals like an Elephant which grabs you with its trunk and tears you in half or flesh eating monkeys you into shreds if you go near them.
Beating Campaign mode can take you over then 12 hours depending on what difficulty you want it on. There a lot of things to do after beating Story. You can replay the game carrying the weapons you've had after beating the game and there are hidden B.S.A.A. badges scattered throughout most levels to find that unlocks new stuff. There is also trophy support if you are want to get all trophies or get a higher rank on certain chapters. Mercenaries' mode returns again which is a mini game where you have to take out as many enemies as you can on certain locations in Resident Evil 5.
If you are online on Playstation 3 yes there is a Resident Evil 5 space on Playstation HOME which will soon be full of online users later through out the weeks.
But if you new to the series it's worth picking up but I would highly recommend you playing the old games before playing Resident Evil 5 then you'll probably notice why a lot of people feel let down that there isn't much horror, mostly action. But however has Capcom really lost its taste in horror? If there is going to be a Resident Evil 6, Capcom should make it scary like the old games like Resident Evil 2 and 3 but keep the same gameplay as Resident Evil 4 and 5.
Sony PS3 Games
Resident Evil 5 (PS3)
benleslie5's review


Southeast metros including New Orleans (32%); Naples, Florida (42%); Wewahitchka, Florida (40%); and Miami (29%) have fairly high rain probabilities, compared to the rest of the US. The same goes for some Northeast cities, like Laurel Summit outside Pittsburgh, Pennsylvania (34%); Mount Washington, New Hampshire (42%); and Lake Placid, New York (31%). Cloudcroft, New Mexico - with a relatively high rain probability of 31% - is a bit of an outlier for the region. Percentages for the rest of the state range from 10% to about 22%.


Prevalence of elder abuse reported by adult children is presented in table 2. Endorsement of each Caregiver Abuse Screen item ranged from 4.8% to 25.1%. Having trouble making parents control his/ her temper or aggression was the most prevalent item among adult children (25.1%), followed by it is children's responsibility to conduct financial transactions on parent's behalf (22.8%) and cannot do what is necessary for parents (22.5%). Feeling being forced to be rough with parents was least reported (4.8%). If the item 1, 3, 5, 9, 10 were removed separately, the prevalence of elder abuse would varied between 55.0% and 58.6%.
The correlation between different items of elder abuse reported by adult children is shown in table 3. Both "act out of character because of parents "and "reject or ignore for parents" were significantly correlated with all other Caregiver Abuse Screen items. The correlation coefficient (r) of all significant correlations varied between 0.10 and 0.49. "Conduct financial transactions on parent's behalf" was correlated to "reject or ignore for parents" at r = 0.10, p < 0.05, while was correlated to "have access to parents' financial account" at r = 0.49, p < 0.001.
The correlation between socio-demographics and elder abuse reported by adult children is presented in table 4. Elder abuse was significantly correlated with younger age (r = -0.10, p < .05), higher level of education (r = 0.20, p < .001), higher income (r = 0.14, p < .01), more years in the U.S. (r = 0.12, p < .05), not born in Mainland China (r = -0.13, p < .01), and English-speaking (r = 0.16, p < .001).
To our knowledge, this is the first study examining elder abuse by adult children among U.S Chinese families. Our study found that 59.8% of participants self-disclosed the risk of having committed abuse towards their older parents; adult children were more likely to report elder abuse if they were younger, with higher level of education, higher income, living in the U.S. for more years, not born in Mainland China, and was able to speak English.
It may be challenging to systematically compare the prevalence of elder abuse in this study with existing studies conducted with family caregivers due to multiple reasons. First, the majority of studies not only included adult children, but also spouses, children-in-law, grandchildren, and other relatives. Second, most studies focused on caregivers who were taking caring of older adults with dementia or disabilities. Third, the measurements that were commonly used differed from this study. In a Hong Kong study sampled 122 family caregivers with 62.3% adult children and 76.2% women involved, 62.3% of them acknowledged that they displayed abusive behaviors toward care recipients in the past month ; Different from our current study, Yan et al.'sstudy utilized the Revised Conflict Tactic Scales (CTS2)as the instrument to measure elder abuse, and the recipients were older adults with dementia.
To compare the results reported by adult children in this study with those observed in the U.S. Chinese aging population [28,40,41], this study displayed a much higher prevalence rate. In a study sampled 3,159 community-dwelling Chinese older adults aged 60 and over in Chicago, the prevalence of the overall elder abuse was 15% when using the Hwalek-Sengstok Elder Abuse Screening Test (H-S/EAST) and the Vulnerability to Abuse Screening (VASS) . The lower rate of elder abuse reported by the U.S. Chinese older adults might be due to the sense of shame and cultural stigma on elder abuse [33,42]; while the adult children, under the impact of acculturation, might perceive less cultural barrier to report elder abuse. Moreover, the way the items of the CASE were phrased, such as "being forced", "finds it difficult" "so tired and exhausted that cannot", did not criticize adult children implicitly and might make them feel more comfortable to provide the real responses.
Most current studies on elder abuse are cross-sectional studies, and the underlying mechanism remains unclear . It is possible that the high prevalence of elder abuse is due to the changing values and the caregiving burden that the adult children are having. Depending on the years living in the U.S., the adult children have become acculturated to Western culture's emphasis on individualism. Compared with their older parents, the adult children are likely to have a different perspective on filial piety [44,45], that is, children being respectful, obedient, and obligated to provide support and care for older parents both emotionally and financially .Take the younger generation in Hong Kong as an example, "love and care" has been perceived as paying for parents' institutional care . A recent study indicated that more than half of the Chinese older adults placed high expectations on filial piety . This discrepancy between the expectations of filial piety and the receipt of filial care may aggravate family conflicts and elder abuse . Apart from the changing values, the caregiving burden is a significant factor associated with elder abuse by family caregivers [19,49,50]. Many adult children are undertaking multiple responsibilities, including career, household duties, and children to take care. Therefore, it is highly possible that the adult children are experiencing a great deal of stress and burden when caring for the older parents . Based on the Situational theory, the stressed and overburdened adult children may become abusive toward their vulnerable parents if they are not able to manage those caregiving demands . Future studies are needed to verify these hypotheses.
Regarding the relationship between socio-demographic factors and elder abuse reported by adult children, this study demonstrated that younger age and higher educational level were positively correlated with elder abuse. Previous studies yielded mixed findings. In a study of 92 caregivers to community-dwelling Chinese older adults in Taiwan, participants with younger age (r = -0.315, p < .01) and higher levels of education (r = 0.219, p < .05) were more likely to perform psychologically abusive behavior . However, a majority of studies did not find the correlation between caregivers' age and abusive behaviors toward older adults with dementia or cognitive impairment [18,21,52,53]. Similarly, the caregiver's educational level was also not related to verbal or physical elder abuse, as shown in Yan et al. 's study. In our current study, it is possible that younger adult children have less experience and insufficient preparation for the heavy caregiving demands; In addition, adult children with higher level of education, also correlated to higher income (r = 0.51, p < .001), are more likely to live in suburban area and have fewer family members to share the caregiving burden with them. These conditions may lead to higher possibility of elder abuse. Currently, there is little previous literature to corroborate above hypothesis. Future research should be conducted to clarify the association between the socio-demographics of caregivers and elder abuse, and explore the influencing mechanism.
The results of this study should be interpreted with limitations. First, the generalizability of our findings to national or international Chinese populations is unwarranted given the location specificity and inner-ethnic variation. Second, the nature of its cross-sectional study design and correlation analysis makes it difficult to postulate on the temporal relationships between socio-demographic variables and elder abuse reported by adult children. Third, the measurements for elder abuse are based on a subjective assessment with a yes/no format, which does not reflect the severity and frequency of elder abuse by adult children. The items for financial abuse may overestimate elder abuse, considering the particular linguistic barriers that the U.S. Chinese older adults are facing. Nevertheless, it may still underestimate participants' actual elder abuse owing to social desirability. Future studies are needed to develop a more culturally sensitive instrument to screen elder abuse by adult children, and can add a multiple-point scale to capture the occurrence rate of elder abuse. Additionally, longitudinal study is necessary to provide further information on the correlates found in the current study.
Despite these limitations, this study has important implications for researchers, health care providers and policy makers. Firstly, it calls for more investigation on elder abuse in U.S. Chinese community from the perspective of perpetrators, including the adult children. Further efforts are needed to understand the risk factors associated with elder abuse reported by adult children. Secondly, health care providers should improve detection of elder abuse in the community settings. Screening elder abuse by family caregivers, such as adult children, is an effective alternative approach to detect elder abuse, considering the Chinese older adults have the tendency to underreport or conceal their abused experiences due to cultural values. Screening elder abuse put health care provider into a proactive position, and is the first step for developing future interventions to prevent elder abuse . It is important for health providers to consider elder abuse interventions from a familial and interpersonal perspective. To understand the dynamics of elder abuse within the context of family caregiving will help health providers to develop a more comprehensive intervention program. Previous research proved that educational intervention and support for at-risk caregivers are effective in mitigating abusive behaviors [55-57]. Thirdly, the findings from this study also have implications to the Elder Justice Act of 2010, which is the first federal legislation addressing elder abuse at the national level and has been implemented currently . The policy maker should place more attention on elder abuse by adult children, and consider relevant cultural issues [59-61].
The elder abuse by adult children is a pervasive health and public issue among U.S. Chinese population. For adult children, younger age, higher levels of education, higher income, living in the U.S. for more years, not born in Mainland China, and English-speaking are positively correlated with elder abuse against U.S. Chinese older adults. Longitudinal research is needed to advance our knowledge on the risk factors associated with elder abuse by adult children.
We are grateful to the Community Advisory Board members for their continued effort in this project. Particular thanks are extended to Bernie Wong, Vivian Xu, Yicklun Mo with Chinese American Service League (CASL), Dr. David Lee with Illinois College of Optometry, David Wu with PuiTak Center, Dr. Hong Liu with Midwest Asian Health Association, Dr. Margaret Dolan with John H. Stroger Jr. Hospital, Mary Jane Welch with Rush University Medical Center, Florence Lei with CASL Pine Tree Council, Julia Wong with CASL Senior Housing, Dr. Jing Zhang with Asian Human Services, Marta Pereya with Coalition of Limited English Speaking Elderly, and Mona El-Shamaa with Asian Health Coalition.
Dr. Dong was supported by National Institute on Aging grants (R01 AG042318, R01 MD006173, R01 NR 14846, R01 CA163830, R34MH100443, R34MH100393, and RC4 AG039085); Paul B. Beeson Award in Aging; the Starr Foundation; the American Federation for Aging.
Dong, X (2015) Elder Abuse- Systematic Review and Implication for Practice. Journal of the American Geriatric Society 63: 1214-1238.
Acierno R, Hernandez MA, Amstadter AB, Resnick HS, Steve K, et al. (2010) Prevalence and correlates of emotional, physical, sexual, and financial abuse and potential neglect in the United States: the National Elder Mistreatment Study. Am J Public Health 100: 292-297.
Begle AM, Strachan M, Cisler JM, Amstadter AB, Hernandez M, et al. (2010) Elder mistreatment and emotional symptoms among older adults in a largely rural population: the South Carolina elder mistreatment study. J Interpers Violence 26: 2331-2332.
Dong X, MA. Simon (2013) Association between reported elder abuse and rates of admission to skilled nursing facilities: findings from a longitudinal population-based cohort study. Gerontology 59: 464-472.
Dong X, MA Simon, and D. Evans (2012) Prospective study of the elder self-neglect and ED use in a community population. Am J Emerg Med 30: 553-561.
Dong X, Simon MA (2013) Association between elder self-neglect and hospice utilization in a community population. Arch Gerontol Geriatr 56: 192-198.
Dong X, Simon MA, Evans D (2012) Elder self-neglect and hospitalization: findings from the Chicago Health and Aging Project. J Am Geriatr Soc 60: 202-209.
Dong X, Simon MA (2015) Elder self-neglect is associated with an increased rate of 30-day hospital readmission: findings from the Chicago Health and Aging Project. Gerontology 61: 41-50.
(1998) The National Elder Abuse Incidence Study. American Public Human Services Association, Washington.
Abolfathi Momtaz Y, Hamid TA, Ibrahim R (2013) Theories and measures of elder abuse. Psychogeriatrics 13: 182-188.
Schiamberg LB, D Gans (2000) Elder abuse by adult children: An applied ecological framework for understanding contextual risk factors and the intergenerational character of quality of life. Int J Aging Hum Dev 51: 329-360.
Yan E, C.S.-K Tang (2001) Prevalence and Psychological impact of Chinese elder abuse. J Interpers Violence 16: 1158-1174.
Dong X (2014) Elder abuse: research, practice, and health policy. The 2012 GSA Maxwell Pollack award lecture. Gerontologist 54: 153-162.
Dong X, Simon MA (2011) Enhancing national policy and programs to address elder abuse. JAMA 305: 2460-2461.
Cooper C, Selwood A, Livingston G (2008) The prevalence of elder abuse and neglect: a systematic review. Age Ageing 37: 151-160.
Yan E (2014) Abuse of older persons with dementia by family caregivers: results of a 6-month prospective study in Hong Kong. Int J Geriatr Psychiatry 29: 1018-1027.
Yan E, Kwok T (2011) Abuse of older Chinese with dementia by family caregivers: an inquiry into the role of caregiver burden. Int J Geriatr Psychiatry 26: 527-535.
Cooper C, Selwood A, Blanchard M, Walker Z, Blizard R, et al. (2009) Abuse of people with dementia by family carers: representative cross sectional survey. BMJ 338: b155.
Kishimoto Y, Terada S, Takeda N, Oshima E, Honda H, et al. (2013) Abuse of people with cognitive impairment by family caregivers in Japan (a cross-sectional study). Psychiatry Res 209: 699-704.
Dong X, Simon MA, Gorbien M (2007) Elder abuse and neglect in an urban chinese population. J Elder Abuse Negl 19: 79-96.
Dong X, Chang ES, Wong E, Wong B, Skarupski KA, et al. (2011) Assessing the Health Needs of Chinese Older Adults: Findings from a Community-Based Participatory Research Study in Chicago's Chinatown. J Aging Res 2010: 124-246.
Shinagawa, LH, D-Y, Kim (2008) A portrait of Chinese Americans: A national demographic and social profile of Chinese Americans. (1st edn), OCA/Asian American Studies Program, University of Maryland, Washington.
Huff R, M Kline (1998) Promoting health in multicultural populations: A handbook for practitioners. (1st edn), SAGE Publications.
Dong X, Chen R, Fulmer T, Simon MA (2014) Prevalence and correlates of elder mistreatment in a community-dwelling population of U.S. Chinese older adults. J Aging Health 26: 1209-1224.
Dong X, Zhang M, Simon MA (2014) The expectation and perceived receipt of filial piety among Chinese older adults in the Greater Chicago area. J Aging Health 26: 1225-1247.
Lee YS, Moon A, Gomez C (2014) Elder mistreatment, culture, and help-seeking: a cross-cultural comparison of older Chinese and Korean immigrants. J Elder Abuse Negl 26: 244-269.
XinQi Dong, E-Shien Chang, Esther Wong, Melissa Simon (2011) Working with culture: lessons learned from a community-engaged project in a Chinese aging population. Aging health 7: 529-537.
Melissa A Simon, Matthew Magee, Lucy Guo, William Cheung, Xinqi Dong, et al. (2008) Building a Chinese community health survey in Chicago: the value of involving the community to more accurately portray health.
XinQi Dong, E-Shien Chang, Esther Wong, Melissa Simon (2014) Perceived barriers and facilitators to implement elder abuse intervention for victims and perpetrators: views from US Chinese older adults. The Journal of Adult Protection 16: 307-321.
XinQi Dong, E-Shien Chang, Esther Wong, Melissa Simon (2011) Sustaining Community-University Partnerships: Lessons learned from a participatory research project with elderly Chinese 4: 31-47.
Pérez-Rojo G, Nuevo R, Sancho M, Penhale B (2015) Validity and reliability of the Spanish version of Caregiver Abuse Screen (CASE). Res Aging 37: 63-81.
Reis M, D Nahmiash (1995) Validation of the caregiver abuse screen (CASE). Canadian Journal on Aging 14: 45-60.
FENG, R-x, X-q, LIU (2010) Evaluation of Reliability and Validity of Chinese Version of Caregiver Abuse Screen for Eldely Patients. Nursing Journal of Chinese People's Liberation Army 17.
Nelson HD, Nygren P, McInerney Y, Klein J; U S. Preventive Services Task Force. (2004) Screening women and elderly adults for family and intimate partner violence: a review of the evidence for the U. S. Preventive Services Task Force. Ann Intern Med 140: 387-396.
Dong X (2014) Do the definitions of elder mistreatment subtypes matter? Findings from the PINE Study. J Gerontol A Biol Sci Med Sci 69 Suppl 2: S68-75.
Chang E, Chen R, Simon MA, Ng J, Dong X, et al. (2012) Elder mistreatment in a community-dwelling population: findings from a large cohort of US Chinese older adults. Gerontologist, Oxford Univ Press Inc, USA.
Dong X, Chang ES, Wong E, Wong B, Simon MA (2011) How do U.S. Chinese older adults view elder mistreatment?: findings from a community-based participatory research study. J Aging Health 23: 289-312.
Dong X (2012) Advancing the field of elder abuse: future directions and policy implications. J Am Geriatr Soc 60: 2151-2156.
XinQi Dong, E-Shien Chang, Esther Wong, Melissa Simon (2012) A qualitative study of filial piety among community dwelling, Chinese, older adults: Changing meaning and impact on health and well-being. Journal of Intergenerational Relationships 10: 131-146.
Chang E (2010) You show filial piety to your children: the changing meanings of filial piety among Chinese elderly immigrants. Gerontologist, Oxford Univ Press Inc, USA.
Simon MA, Chen R, Chang ES, Dong X (2014) The Association Between Filial Piety and Suicidal Ideation: Findings From a Community-Dwelling Chinese Aging Population. J Gerontol A Biol Sci Med Sci 69: 90-97.
Yan E, Chan KL, Tiwari A (2015) A systematic review of prevalence and risk factors for elder abuse in Asia. Trauma Violence Abuse 16: 199-219.
Dong X, M. Zhang (2015) Gender Difference in the Expectation and Receipt of Filial Piety Among US Chinese Older Adults. Journal of Social Science Studies 2.
Wang JJ, Lin JN, Lee FP (2006) Psychologically abusive behavior by those caring for the elderly in a domestic context. Geriatr Nurs 27: 284-291.
Wang JJ (2005) Psychological abuse behavior exhibited by caregivers in the care of the elderly and correlated factors in long-term care facilities in Taiwan. J Nurs Res 13: 271-280.
Cassie KM, Sanders S (2008) Familial caregivers of older adults. J Gerontol Soc Work 50 Suppl 1: 293-320.
Cooper C, Blanchard M, Selwood A, Walker Z, Livingston G (2010) Family carers' distress and abusive behaviour: longitudinal study. Br J Psychiatry 196: 480-485.
Lee M, Kolomer SR (2005) Caregiver burden, dementia, and elder abuse in South Korea. J Elder Abuse Negl 17: 61-74.
Dong X (2015) Screening for Elder Abuse in Healthcare Settings: Why Should We Care, and Is It a Missed Quality Indicator? J Am Geriatr Soc 63: 1686-1692.
Hsieh HF, Wang JJ, Yen M, Liu TT (2009) Educational support group in changing caregivers' psychological elder abuse behavior toward caring for institutionalized elders. Adv Health Sci Educ Theory Pract 14: 377-386.
Forrest Scogin, Colleen Beall, Jerry Bynum, Gretchen Stephens, Nicholas Philip Grote, et al. (1990) Training for abusive caregivers: An unconventional approach to an intervention dilemma. Journal of Elder Abuse & Neglect 1: 73-86.
Dong X, Chang ES, Wong E, Simon M (2013) Perceived effectiveness of elder abuse interventions in psychological distress and the design of culturally adapted interventions: a qualitative study in the chinese community in chicago. J Aging Res 2013: 845425.
Dong X, MA Simon (2012) Elder abuse: Existing national policies and programs to defend the rights and safety of older adults. Public Policy Aging Report 22: 1-7.
Chang ES, Simon M, Dong X (2012) Integrating cultural humility into health care professional education and training. Adv Health Sci Educ Theory Pract 17: 269-278.
Dong X (2012) Culture diversity and elder abuse: implications for research, education, and policy. Generations 36: 40-42.
Simon MA, E Chang, X Dong (2010) Partnership, reflection and patient focus: advancing cultural competency training relevance. Medical education 44: 540-542.


The Automotive Restoration Market Organization (ARMO) will install new leadership following its most recent election cycle. Dennis Roberts, vice president of Distinctive Industries, will take over the chair position, and Erika Wiesman, the owner of Hydro-E-Lectric Inc., was selected as chair-elect. They laid out their backgrounds and plans in recent interviews with SEMA Member News.
Roberts has been involved in the restoration industry for more than 30 years after having been introduced to musclecars in 1970 through a '70 Trans Am owned by a friend of his older sister. He bought a '67 GTO as his first car in 1974 at the height of the gas shortage and became a hands-on restoration enthusiast for life.
Tom Pickett has been a Jeep enthusiast for most of his life. He bought one at the end of 2009 but quickly realized that there was nowhere to buy parts for it in Chattanooga, Tennessee. So, in February 2010, he decided to walk away from a lucrative career in automotive manufacturing and build the foundation for Tom's 4x4 Superstore—a Jeep and off-road parts supplier and installer that officially opened in June of that year.
Be Your Own Disc Jockey!
If you think texting while driving is a distraction, imagine changing 45-rpm records while barreling down the highway.
Read more about Be Your Own Disc Jockey!
Once a year, SEMA provides members with a way to select the Board of Directors—the volunteers who help SEMA make decisions that will help your business and the industry to succeed. I want to thank the many members who participated in the nomination process; we have some very strong candidates again this year. And thanks in advance to all of you who will be first-time voters, as well as all our regular voters.
2015 Ford Focus ST and Ford F-350 Super Duty Smokestacks.
Breaking news from SEMA members, including the Coker Group, Champion Oil, Marx Group Advisors, ESAB-a member of the Colfax group of companies, Fox Factory Holding Corp., and more.


Despite a growing body of literature illustrating the benefits of self-compassion (e.g., increased psychological well-being; Ferguson et al., 2014), men athletes are underrepresented in self-compassion research. Findings suggest men athletes have particularly high levels of adherence to traditional masculine norms (e.g., dominance; Connell & Messerschmidt, 2005; Wasylkiw & Clairo, 2016), which might make self-compassion a challenging concept for them (Reilly et al., 2013). However, men athletes' experiences of self-compassion might be contingent on their varying experiences of masculinity, supported by a contemporary version of masculinity premised on acceptance of all embodiments of masculinity (i.e., inclusive masculinity; Anderson, 2005) that seems more conceptually aligned with self-compassion. To explore the relationship between masculinity and self-compassion, we sampled 211 men athletes (Mage = 22.8) from a variety of sports and competitive levels. Results show self-compassion is negatively related to traditional masculine norm adherence (r = -.31), three subscales of traditional masculine norm adherence (i.e., self-reliance, r = -.33; emotional control, r = -.29; violence, r = -.22), and fear of compassion for oneself (r = -.48), while being positively related to inclusive masculinity (r = .27). Self-compassion also predicted unique variance beyond self-esteem on traditional masculine norm adherence (4.1%), individual subscales of masculine norm adherence (i.e., winning, 9.5%; violence, 5.9%; emotional control, 4.3%; self-reliance, 2.9%), and fear of compassion for oneself (2.2%). In conclusion, a strong adherence to traditional masculine norms may impede men athletes from experiencing benefits of self-compassion, while a more accepting attitude towards other men's masculinities seemingly aligns with self-compassion.


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Roger Grant is a highly-experienced editor and post-producer of live and animated television drama, features, short films and documentaries. heis currently post producing Kim Webby's feature documentary From Raids to Reconiliation and Tearepa Kahi's feature Poi E.
In 2005 he established Conbrio Media in Auckland to promote HD post-production of features and television using Final Cut Pro and AVID editing systems.
Working as a producer for Digital Post Ltd he oversaw VFX post on features and international tv series, including the Spartacus series, Mt Zion, Beyond the Edge, Giselle, Love Birds, The Most Fun You Can Have Dying.
Previously Roger established New Zealand's first Avid facility, TopStory Productions, where he developed his reputation for mentoring new editors. Key productions Roger supervised during this time include the feature Topless Women Talk About Their Lives. He also edited many television drama series including the Nga Puna and Tala Pasifika series of Maori and Polynesian stories.
For a period he lived in Sydney Australia, where he established a Final Cut Pro editing facility for Yoram Gross-EMTV, a leading animation producer, for whom he edited the animated feature Tabaluga and Leo as well as supervising hundreds of hours of animated television.
Roger has always taken a strong interest in supporting up-and-coming filmmakers and extended this interest into executive producing short films together with Christina Milligan and Rawiri Paratene under the banner shorts conbrio.


by R. David Cox. Wm. B. Eerdmans Publishing Co. (Grand Rapids, Michigan, 2017). 336 pp., $26.
Amid the turmoil that has risen from demonstrations for and against the monuments, in "The Religious Life of Robert E. Lee," R. David Cox provides insight into an aspect of the Confederacy's most prominent figure.
To be sure, this book will have no impact whatsoever on resolving the stay/go arguments surrounding Lee monuments. However, it provides a perspective as to how Lee, an Episcopalian, was formed in the faith, and how he applied those beliefs on matters of his day, particularly slave ownership and states' rights, and leading an army into war to maintain both.
To establish that perspective, Cox goes deep into Lee's life, detailing the influence of his parents and his wife, as well as other relatives and friends, and continuing that detailed narrative throughout the remainder of the general's life.
In fact, detail is an essential part of this work, maybe overwhelming at times. Nonetheless, it is critical as his source material includes scholarly historical works, and, more importantly, he draws upon the correspondence written by and received by Lee to establish what one could consider the general's faith journey.
It is from these letters that the reader sees the evolution of that faith through various stages of his life — from youth to West Point cadet to military leader to husband and father to cavalry commander to leader of and defeat of the Confederate army to college president.
Readers will appreciate the attention Cox, an Episcopal priest since 1972 and a professor of history at Southern Virginia University since 2006, devotes to each of these areas, as together they provide a composite of Lee's spirituality and how it is entwined with other aspects of his life. He was not without the struggles one experiences in trying to discern the will of God and applying it to his daily life.
Cox states as much, "As a person of faith, convinced of God's providence, he had to wrestle with what seemed to be the will of God, and how he had been on the wrong side of it; the Lord had 'decided against' him and his cause." Might that be a statement readers could apply to their own lives?


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James Webb Telescope Observes Clouds Beneath Saturn's Moon 'Titan' In Extraordinary Detail
Fact: It is our solar system's sole moon with a dense atmosphere.
By Hadi Khan Dec. 2, 2022
Titan is one of our solar system's most fascinating Moons. This greenish-blue world belongs to Saturn, another gorgeous planet. Titan is our solar system's only moon with a dense atmosphere 4 times denser than Earth's.
Credit: NASA// Image Of Titan
In November, the James Webb Space Telescope pointed its instruments at this fascinating world and made a remarkable finding that has surprised the globe. Apart from Earth, Titan is the only planetary body in our solar system with rivers, lakes, and seas.
According to a NASA statement, "However, unlike Earth, the liquid on Titan's surface is made up of hydrocarbons like as methane and ethane rather than water. Visible light reflecting from the surface is obscured by the atmosphere's dense haze."
The most powerful telescope in the world transmitted the first images of Titan on November 5, 2022. In a blog post, planetary scientist Conor Nixon wrote, "At first glance, it is simply extraordinary!"
SEE ALSO: Titan, Saturn's 'Crazed' Earth-Like Moon, Is Showing Signs Of Life
What do the images represent?
The pictures were taken by Webb's principal imaging tool, the NIRCam, which picks up infrared light. In the northern hemisphere, two clouds could be seen in Webb's vision.
Peer review of this work has not yet occurred. The Keck telescope, a land-based observatory located in Hawaii, was used for additional study to look into the potential motion or shape changes of the clouds.
Whether these are the same clouds that have changed shape or entirely different clouds is currently a mystery. Clouds on Titan are predicted to form and disappear quickly.
I was able to see its surface in visible light but idk maybe I'm built different
— Frank Senators (@sleepenbaker) December 1, 2022
Cover Image: NASA
Topics: Science, James Webb Space Telescope, Titan
This Timelapse Shows Dance Of Alien Worlds Around A Massive Young Star; Watch
An amazing video shows extraterrestrial worlds circling their parent star, which is 133.3 light-years away from Earth
From 'Mount Everest' To 'Victoria Falls': 8 Natural Wonders Of The World
Top 7 Scientific Reasons Why Humans Haven't Discovered Alien Life Yet
From 'Mini Mercury' To 'Chilly Neptune': Let's Take A Tour Together Of Solar System Through These Majestic Images
Budget 2023: India Will Set Up 157 Nursing Colleges To Eliminate 'Sickle Cell Anemia'; Find Out What It Is
Sickle cell anemia is an inherited blood condition that affects the body's red blood cells.


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Onco Actu du 31 août 2017
France to vote against license renewal for weedkiller glyphosate [Reuters]
A vote on whether to renew the license is due on Oct. 4, the French official said. A qualified majority of member states is needed for the renewal to go ahead.
3.1.1 Tabac - e-cigs
Most young people who try e-cigarettes don't become regular users, says study [Cancer Research UK]
The study, part-funded by Cancer Research UK, collated 5 surveys that questioned more than 60,000 young people in total, aged 11-16.
3.8 Prévention - Alimentation
The fat vs. carbs merry-go-round spins again [HealthNewsReview]
The study authors appropriately mentioned — but very few reporters discussed — the confounding issue of socioeconomic status at play in this international study.
Modified Stem Cells Deliver Chemotherapy to Metastatic Tumors [NCI]
An exciting characteristic of the approach, Dr. Kaplan continued, is that it is adjustable and dynamic, which means that it may potentially be fine-tuned to an individual patient's needs.
Beta Blockers May Hold Key to Unleashing Potential of Checkpoint Inhibitors, Roswell Park Team Shows [Roswell Park Cancer Institute]
Existing therapies capable of reducing stress responses may boost effectiveness of immunotherapy.
5.12.2 Immunothérapies - CAR-T
FDA approves Roche's Actemra/RoActemra (tocilizumab) for the treatment of CAR T cell-induced cytokine release syndrome [Roche]
Actemra/RoActemra is the first FDA-approved treatment for severe or life-threatening cytokine release syndrome induced by CAR T cell therapy.
Star team quietly raises $21M to launch the latest immuno-oncology startup Torque [EndPoints]
We want to activate only the T cells that are going after the tumor, and we do this by anchoring the immunomodulators to the surface of the immune cell to act locally, in the microenvironment.
FDA Approves Pioneering Cancer Treatment With $475,000 Price Tag [Wall Street Journal]
"It will leave patients and others wondering" why $475,000 is the right price "instead of 175 [thousand], 600, 750 or any other number," Dr. Pearson said. "And questions will remain about how this price will affect patients' ability to access the drug, and how it will be used to set a benchmark for other uses of this drug and perhaps other cancer drugs in the future."
ASH President Comments on FDA Approval of First CART-Cell Therapy to Treat Childhood Leukemia [ASH]
"While the importance of CAR-T cannot be overstated, this approval only pertains to a small population of children."
FDA Approves First CAR-T Cell Therapy for Pediatric Acute Lymphoblastic Leukemia [NIH Director's Blog]
Immunotherapy is indeed the achievement of many minds. At the same time, the commitment and passion of researchers such as June and Rosenberg—and James Allison of the University of Texas MD Anderson Cancer Center, Houston, for checkpoint inhibitors—have been essential to pushing past obstacles and skeptics, and bringing us to this remarkable moment in medicine's history.
A $475,000 price tag for a new cancer drug: crazy or meh? [STAT]
In conjunction with the Centers for Medicare and Medicaid Services, Novartis announced that it will be entering the market in a manner that its next approved indication for Kymriah may have a different price from the $475,000 announced on Wednesday.
Novartis receives first ever FDA approval for a CAR-T cell therapy, Kymriah(TM) (CTL019), for children and young adults with B-cell ALL that is refractory or has relapsed at least twice [Novartis]
Novel approach to cancer treatment is the result of pioneering CAR-T cell therapy collaboration with University of Pennsylvania.
Novartis Wins Historic FDA Nod, Prices CAR-T For Leukemia at $475,000 [Xconomy]
"1 month response is not an outcome. 18 (or 24 or 36) [months] free of relapse without allo Tx"—a reference to bone marrow transplant, the only current way to cure this type of leukemia—"should be the reimbursable outcome."
Novartis crosses FDA finish line with monumental CAR-T leukemia approval [FiercePharma]
Of course, plenty of questions remain as CAR-T use is just ramping up, but leaders in the field have made progress with manufacturing and logistical problems lately, as well as safety, which previously plagued Juno Therapeutics.
FDA Approves CAR T-cell Therapy for Pediatric Acute Lymphoblastic Leukemia [ACS]
The FDA based its approval on a small clinical trial of 63 young people with B-cell precursor ALL who had run out of all other options for treatment. The overall remission rate within 3 months of treatment was 83%.
FDA Approves Novartis Treatment That Alters Patients Cells To Fight Cancer [Forbes]
Novartis bought the rights to the Penn treatment for just $20 million up front. "I've told the team that resources are not an issue. Speed is the issue," says Novartis' Chief Executive Joseph Jimenez, told Forbes in a cover story about the work then.
US approves first cancer drug to use patient's own cells – with $475,000 price tag [The Guardian]
Though the price may be shocking to many, analysts will probably view the $475,000 price tag as conservative. A British study suggested the "upper bound" for a drug like Kymriah could be $649,000.
Modified T cells that attack leukemia become first gene therapy approved in the United States [Science]
The FDA decision was expected after an agency advisory panel met in July to discuss the risks and benefits of the Novartis treatment. Panelists raised some safety concerns, but voted unanimously to recommend approval.
Novartis CEO's Dilemma: Is $475,000 Too Much For A Leukemia Breakthrough? Or Is It Not Enough? [Forbes]
It's conceivable that later on other CAR-T's could be worth more – Jimenez points to promising data combining Novartis' technology with AbbVie's cancer drug Imbruvica. But it's also possible they could be worth less.
FDA ushers in a new era in cancer treatment with 'historic' CAR-T approval for Novartis [EndPoints]
It's a big day in the biotech world, but it's just the official start date for a new era.
The FDA Has Approved the First 'Gene Therapy' for Cancer [MIT Technology Review]
Kymriah will initially be available at 20 U.S. hospitals within a month, Novartis says. Eventually, 32 total sites will offer the therapy.
F.D.A. Approves First Gene-Altering Leukemia Treatment, Costing $475,000 [NY Times]
Because Kymriah can have life-threatening side effects, including dangerous drops in blood pressure, the F.D.A. is requiring that hospitals and doctors be specially trained and certified to administer it, and that they stock a certain drug needed to quell severe reactions.
FDA approval brings first gene therapy to the United States [FDA]
CAR T-cell therapy approved to treat certain children and young adults with B-cell acute lymphoblastic leukemia.
Juno, bluebird In Focus as Targets Following Gilead-Kite Aquisition [The Street]
The transaction is a "boon for the cell therapy space in general" and "heralds big biotech's view regarding the promise of cell therapy, opening the door for more favorable deals going forward as companies evaluate how to position themselves in the oncology space."
Bristol-Myers Squibb Data at ESMO 2017 Demonstrate Company's Innovative Research Approach to Treating Cancer from All Angles [BMS]
Long-term survival and safety data to be presented for Opdivo in advanced melanoma, non-small cell lung cancer and head and neck cancer.
Clovis Oncology to Present Comprehensive Dataset from Successful ARIAL3 Clinical Trial Program at 2017 ESMO Congress [Clovis]
Comprehensive results from Phase 3 ARIEL3 maintenance treatment trial of rucaparib in advanced ovarian cancer patients accepted as late-breaker presentation, will be highlighted in ESMO press program.
5.6.4 ESMO - Poumon
ESMO 2017 Press Release: IFCT-0302 results question role of CT-scan in NSCLC post-surgery follow-up [ESMO]
The findings suggest regular CT scans, which many guidelines recommend, may not be necessary.
AstraZeneca highlights latest advances in lung cancer at the ESMO 2017 Congress [AstraZeneca]
More than 40 presentations, including data from two pivotal trials selected as late-breaking abstracts for oral presentation in the ESMO Presidential Symposia.
Publishing national chemotherapy data has helped NHS hospitals make changes that should improve treatment [Cancer Research UK]
The new information has already changed how some hospitals manage and review chemotherapy treatment. But this is just the beginning. Public Health England is now exploring other ways of using data to help improve patient outcomes.
UK needs to act urgently to secure NHS data for British public, report warns [The Guardian]
Sir John Bell, a professor of medicine at Oxford university who led the government-commissioned review, said that NHS patient records are uniquely suited for driving the development of powerful algorithms that could transform healthcare and seed an "entirely new industry" in AI-based diagnostics.
In a Sign of Gene-Editing Frenzy, Startup Pitches Editing without CRISPR [MIT Technology Review]
"What's surprising is this company raised so much money on something thought to be untrue in the scientific community," says David Russell, a researcher at the University of Washington, in Seattle.


Finding convenient and cost-effective modes of travel is one of the most important requirements of modern life. While most people find viable solutions for handling daily commutes or that one-off vacation, problems can start surfacing very quickly whenever you find the need of traveling in a large group. If you are arranging a party or an event and want to get all of your guests to your venue at the same time, it might take some time to find the right transportation. If you are planning for a day out in town or a small trip nearby with a large group of family and friends, finding transportation that can be cost-effective and convenient at the same time might become difficult. These are situations where individual cars are small vehicles can become inadequate and relying on public transit options can quickly become inconvenient and put a hole in your plans. Considering a bus charter service can be one of the best options when you have such requirements, and for good reasons.
If you try and think about a good transport option when there is a large group involved, the benefits of bus travel can immediately come to mind. Not only can a large group travel comfortably on a bus, but traveling by bus can also open up a host of other benefits that can convince you about this being the perfect transport option while traveling in a group. It is easy to rent a charter bus in most places and you can definitely take a look at local bus services and charter bus companies in your area to find the right vehicle for your needs. It is important that you remain aware of all the benefits when it comes to this mode of transportation. Let us take a closer look.
When you come to think of it, the basic benefits of bus charter services can become apparent. If you are traveling with a large group of people, finding adequate space for everyone on your choice of transportation can be very important. Unless you want to split up your group and travel in batches or separately with smaller transport, bus travel can be one of the best options. Keeping things cost-effective can also become important in these situations and companies offering charter bus services usually have different sizes of vehicles. If you have a medium group, you can take a look at small charter buses while if you have a larger group, larger vehicles can be on offer, allowing you to keep your travel must effective at all times.
Apart from the ease of bus travel, one of the most important advantages of bus charter services is the fact that you can operate according to your own schedule. This is a luxury that you definitely cannot enjoy if you rely on public transit. Charter bus rentals will operate according to your schedule with enough room to make changes and keep things flexible. If you have a sudden change of mind during your trip, you can definitely instruct your driver to change your schedule partially or even fully.
Other important advantages of charter bus services can definitely include the environmental aspect of things. Having one vehicle for a large number of people is definitely the more eco-friendly way of accomplishing travel duties. Apart from this, a lot of companies offering bus charter services also take a lot of care when it comes to comfort on board a bus. To accomplish this, most of these vehicles are fitted with a number of charter bus amenities that can make your travel experience comfortable and relaxing. Having an all-encompassing vehicle that allows comfortable and convenient travel, can always run according to your schedule, and keeps costs down can definitely be a great option if you want to really have a good time with your family and friends while traveling in a large group.
These are some of the most important advantages you can enjoy if you avail bus charter services. Considering all the other options, this can definitely be one of the best solutions when it comes to traveling in a group.