Fiction. Latinx Studies. Jewish Studies. LGBTQIA Studies. Women's Studies. In America, we're good at dividing ourselves into tribes—into "insiders" and "outsiders"—based on race, background and beliefs. But what happens when a person is an outsider within her own tribe? Serach Gottesman, the mathematically-gifted eldest daughter of a rigidly Orthodox Jewish Boro Park family and Paloma Rodriguez, the street-smart Bronx-bred daughter of a neglectful Latina immigrant mother, seek broader vistas within a relationship that is forbidden by both their communities. Love provides them ballast, but they find that some cultural bonds grip tight and some wounds run deep.
S.W. Leicher grew up in the Bronx in a bi-cultural (Latina and Jewish) home. She moved to Manhattan after graduate school and raised her family on the Upper West Side, where she still lives with her husband and two black cats. She spends most of her time writing about social justice issues. ACTS OF ASSUMPTION is her first novel.


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Swachh Bharat : 93.4% Rural Households Who Have Access To Toilet Use It, Says NARSS Survey
The National Annual Rural Sanitation Survey (NARSS) 2017-18, conducted by an Independent Verification Agency (IVA) under the World Bank support project to the Swachh Bharat Mission Gramin (SBM-G), has found that 93.4% of the households in rural India who have access to a toilet use it. The NARSS also re-confirmed the Open Defecation Free (ODF) status of 95.6% of villages which were previously declared and verified as ODF by various districts/states. The survey was conducted between mid-November 2017 and mid-March 2018 and covered 92040 households in 6136 villages across States and UTs of Bharat.
The key findings of NARSS 2017-18 are as follows:
77% of households were found to have access to toilets during the survey period
93.4% of the people who had access to toilets used them
95.6% of villages which were previously declared and verified as ODF were confirmed to be ODF. The remaining 4.4% villages also had sanitation coverage of over 95%
70% of the villages surveyed found to have minimal litter and minimal stagnant water
The IVA presented their findings to the Expert Working Group (EWG) constituted for oversight of NARSS, comprising representatives from organizations including the World Bank, UNICEF, Water Aid, Bill & Melinda Gates Foundation, India Sanitation Coalition, Sulabh International, Knowledge Links, NITI Aayog, Ministry of Statistics and Program Implementation. The EWG noted the satisfactory completion of the survey. Following this, the IVA submitted their provisional summary results report and raw data to the Ministry of Drinking Water and Sanitation, and the same have been uploaded and made publicly accessible on the Ministry of Drinking Water and Sanitation website (mdws.nic.in).
The survey used the PPS (Probability Proportion to Size) sampling methodology. Data was collected using the Computer Assisted Personal Interviewing (CAPI) platform. The survey also covered schools, anganwadis and public/community toilets in these villages.
Since its launch in October 2014, the SBM, the world's largest sanitation program, has changed the behaviour of hundreds of millions of people with respect to toilet access and usage. 300 million people have stopped defecating in the open since the SBM began, down from 550 million at the beginning of the programme to about 200 million today. Over 6.5 crore toilets have been built across rural India under the Mission.
Over 3.38 lakh villages and 338 districts have been declared ODF, along with 9 ODF States and 3 Union Territories, namely Sikkim, Himachal Pradesh, Kerala, Haryana, Uttarakhand, Gujarat, Arunachal Pradesh, Chhattisgarh, Meghalaya, Chandigarh, Daman & Diu and Dadra & Nagar Haveli.
(Source: PIB Press Release from Ministry of Drinking Water and Sanitation)
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Pakistan's economic meltdown triggers infighting; blame game among political class intensifies
सूरत और दिल्ली में दिल्ली के कंझावला काण्ड के जैसी ही दो और दुर्घटनाएं: परन्तु चुप्पी क्यों? हर दुर्घटना में स्त्री विमर्श कहीं हिन्दुओं...
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Another step towards decolonization: 'Mughal Garden' renamed to Amrit Udyan
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redpajama_set_name: RedPajamaCommonCrawl


text:
<?php

namespace EasyMinerCenter\Model\Data\Entities;
use Nette\NotSupportedException;

/**
 * Class DbConnection
 * @package EasyMinerCenter\Model\Data\Entities
 * @author Stanislav Vojíř
 * @license http://www.apache.org/licenses/LICENSE-2.0 Apache License, Version 2.0
 *
 * @property string $type = m:Enum("mysql","limited","unlimited")
 * @property string|null $dbServer = null
 * @property string|null $dbApi = null
 * @property string $dbPort
 * @property string $dbUsername
 * @property string $dbPassword
 * @property string $dbName
 */
class DbConnection{
  const TYPE_MYSQL='mysql';
  const TYPE_LIMITED='limited';
  const TYPE_UNLIMITED='unlimited';
  const TYPE_MYSQL_NAME='MySQL';
  const TYPE_LIMITED_NAME='Limited DB (recommended)';
  const TYPE_UNLIMITED_NAME='Unlimited DB';

  /**
   * Function returning a connection string inspired by connection string for PDO, but including some properties of DbConnection
   * @return string
   */
  public function getConnectionString() {
    return $this->type.(!empty($this->dbName)?':dbname='.$this->dbName:'').(!empty($this->dbServer)?';host='.$this->dbServer:'').(!empty($this->dbApi)?';api='.$this->dbApi:'').';port='.$this->dbPort.';charset=utf8;user='.$this->dbUsername;
  }

  /**
   * Function returning PDO connection string
   * @return string
   * @throws NotSupportedException
   */
  public function getPDOConnectionString() {
    if ($this->type==self::TYPE_MYSQL){
      return 'mysql:host='.$this->dbServer.';'.(!empty($this->port)?'port='.$this->port.';':'').(!empty($this->dbName)?'dbname='.$this->dbName.';':'').'charset=utf8';
    }else{
      throw new NotSupportedException('PDO connection is not available for DB type '.$this->type);
    }
  }

}

redpajama_set_name: RedPajamaGithub


text:
Mix Engineering
Blog: Production Tips
PRODUCER TIP: Free Track Downloads
Home / Producer Tips
08December
domkane
Producer Tips, Uncategorized
I'm seeing more and more DJs and Producers giving away free music downloads these days. Here are some of my thoughts on the matter… Obviously, it's totally up to the artist on whether they want to give their music away for free, (I've done it myself a few times), but I think we all need to stop and think about a few things first… For example, most people I know who give away free music seem to think that's it's a promotional tool for gaining some new exposure. But is there any actual proof that giving music away for free actually does any good in leading to sales and gig bookings etc? Especially when it's only being given away via that artists social network pages. The only people I've ever known to get any major exposure from giving away free tracks, are people who were already famous in the first place, and already had plenty of gigs and album sales. Have you ever heard of someone who became famous/successful purely because they gave their music away for free?
Secondly, who are the people most likely to download your free music? Your existing followers on your social networks? Of course they are! So if you only allowed a streaming preview instead of giving the whole thing away for free, it wouldn't be any different would it? Sure, a free download might get passed on to a mate of a mate, but that's not going to happen in any significant numbers. Again, perhaps if the download was being offered on the front page of a hugely popular website, then this could bring new exposure, but if it's just on your own social networks to your existing fans and followers, then you're hardly going to make a huge impact.
Originally, the whole idea of giving a track away for free, was supposed to be some sort of "exclusive reward" or a one-off case of "giving something back to the fans"…And while that's a good thing to do, if you don't already have a significant amount of fans, then giving stuff away for free is basically like saying "I'm not worth any money" or even "no record label wanted to sign this and give it a proper release".
At this stage, you might be thinking "Oh but I'll only do it once a year", but the fact that virtually every DJ and Producer I follow on Twitter and Facebook gives away a track at some point at least once a year, when you multiply this out by the number of DJs and Producers in the world, you end up with a world of constant free music downloads from everyone of all shapes and sizes, and this in itself devalues music as an art form, and lowers the expectations of every music fan out there to the point where people start to detest the idea of paying even 79p for a track… Then we all start to wonder why nobody buys our music?
So what it really comes down to is this question:
By giving away free music, are you really gaining *new* fans that will then buy your next single/tickets/merch?
I'm yet to see any evidence of this. Of course, it's almost impossible to measure due to the natural growth of existing fan bases and social networks already… I mean you could compare before/after stats on social networks etc, but again, even if you gained 100,000 fans on Facebook from giving away a free track, you still don't get the answer of how many of these people will listen to your next track, let alone pay for your next single/gig/merch.
As an artist, you can't start giving everything away for free, and then complain when you can't afford to eat.
New Vlog Video Series December 06, 2016
PRODUCER TIP: Linear Phase EQ September 12, 2016
Why I Tried To Quit The Music Industry June 13, 2016
PRODUCER TIP – Compression Techniques October 30, 2012
PRODUCER TIP: Ableton Automation Delay October 30, 2012
An open letter to Boris Johnson + Ministry Of Sound October 30, 2012
New Vlog Video Series
PRODUCER TIP: Linear Phase EQ
Why I Tried To Quit The Music Industry
The Five Levels of Mix Quality
15 Essential Tips for New Audio Engineers
Free VST
Loops Pack
Mic Technique
Software / VST / AU
Studio Technique
Copyright © 2015 Kane Audio. All rights reserved.


It's possible that early farmers didn't actively select for better crops, and crop domestication simply 'happened' under their noses, a new paper reports.
Ahh, agriculture. I'm a huge fan. It comes with some very harsh drawbacks, for the environment and our way of life both, but it also underpins pretty much everything about human society. Agriculture allows for some people to generate a food surplus, which means that other people don't have to hunt or scavenge, so they can focus on more noble pursuits — such as writing for ZME Science. Again, a huge fan.
The agricultural revolution was a defining point in human history, and yet we don't know very much about it. One aspect, in particular, piqued the interest of researchers from the Grantham Centre for Sustainable Futures at the University of Sheffield — crop domestication.
If I'd ask you to imagine a hunter-gatherer plying his trade you'll probably imagine a guy like you and me, dressed in furs, picking let's say apples from a tree. Big, juicy, shiny apples. Which is oh so, so wrong. That's the image we associate with apples because it's how we've seen them in stores and on the internet and wherever our whole lives.
But that's not at all how they looked back then. The fruits (and probably prey) hunter-gatherers had access to were wild, less tasty, tiny, and most importantly less energy dense.
The stuff we eat today would blow our stone-age ancestors' fur socks away, and it's all due to crop domestication. Through constant artificial selection, farmers have coaxed their crops into producing more 'food' and less of anything else — for example, the grains we plant today have lost their wild seed dispersal capacity, and rely completely on humans to spread. This dependency allowed farmers to create better crops over time — and better crops provided an exponential increase in crop yield compared to wild crops.
The transition from wild to domesticated crops happened during the early days of farming in the Stone Age, some 10,000 years ago, and there's still a lot of questions about the issue we just don't have an answer to. Professor Colin Osborne from the Grantham Centre for Sustainable Futures at the University of Sheffield and his team set out to answer one particularly interesting one: did early farmers know they were breeding certain characteristics into their crops or did these domesticated traits take root under their noses as the plants adapted to being taken care of?
The team looked at seed sizes for a range of crops believed to have been domesticated in antiquity to find evidence of domestication. For seed crops, they looked at a range of cereals and pulses domesticated in different parts of the world. For vegetable crops, they analyzed both species that are typically grown from seed, and species that are vegetatively propagated (from cuttings/roots, such as potatoes). Fruit crops were not included in these comparisons.
The theory is that if people selected for better crops, the effects would be seen in leaves, stems, roots, or fruit, which are eaten as food. Vegetables are propagated by planting seeds, cuttings, or tubers but harvested for the parts I listed above, so seed size is not a direct determinant of yield. As such, domestication should not have had any effect on the seeds, as they had no particular nutritional use.
Changes in vegetable seed sizes instead must have stemmed from natural selection processes acting on cultivated crops, or from genetic links between them and other characteristics of the crops, such as plant or organ size — i.e. if the size of seeds is directly tied to the size of the plant and farmers select for larger plants, seed size would also unintentionally increase.
"We found strong evidence for a general enlargement of seeds due to domestication across seven vegetable species," said Professor Osborne.
The findings suggests that some, if not the majority of changes that took place in our staple crops during the early days of agriculture took place without deliberate selection from farmers. So overall, it's likely that unintended selection was the main driver of crop evolution and crop yield increase in early farms. Understanding how crops evolved will help us better guide selection efforts in the future.
The full paper "Unconscious selection drove seed enlargement in vegetable crops" has been published in the journal Evolution Letters.


Microsatellite instability-high (MSI-H) tumors comprise approximately 4% of patients with colorectal cancer (CRC), and those patients are likely to respond to checkpoint inhibitors, such as nivolumab (Opdivo) and pembrolizumab (Keytruda), according to Tanios Bekaii-Saab, MD.
An emerging area of research is attempting to have the remaining 96% of patients with CRC respond to immunotherapy. An ongoing phase III study is investigating that question by combining the MEK inhibitor cobimetinib (Cotellic) with the PD-L1 inhibitor atezolizumab (Tecentriq; NCT02788279). Results of this trial are expected to read out in the coming months.
"Strategies such as introducing a MEK inhibitor seem to invite tumor-infiltrating lymphocytes, which could perhaps increase the yield of response," explained Bekaii-Saab, a professor of medicine at Mayo Clinic.
In an interview during the 2017 OncLive® State of the Science SummitTM on Gastrointestinal Malignancies, Bekaii-Saab discussed the emerging role of immunotherapy in patients with MSI-H tumors and beyond.
Bekaii-Saab: My discussion focused on the role of immunotherapy, specifically PD-1 and PD-L1 inhibitors, in patients who have MSI-H tumors. Those are cancers that lack the expression of some proteins. This is a surrogate marker for tumors that are loaded with mutations, such as hypermutated tumors.
The presence of this MSI-H phenotype is dependent on 2 elements. Firstly, it could be acquired through the genetics of the patients, such as in the setting of Lynch syndrome. The other group would acquire this sporadically. This is 4% of patients in the metastatic setting.
In the earlier stages, the percentage is higher. Stages II to III are anywhere between 15% to 18% of patients. In the earlier stages, it is a good prognosis; whereas, in the later stages, it is an incredibly poor prognosis. In those patients with hypermutated or hyperinflamed tumors, there is a higher likelihood to see responses from immunotherapies. When looking across the board at single-agent PD-1 inhibitors with pembrolizumab or nivolumab, there are no responses in CRC.
On the other hand, when looking at the patient population that has this MSI-H phenotype, you do see a response rate up to 50% to 60%. More interestingly, as we look over time in recent publications from the authors of a study that looked at pembrolizumab in patients with MSI-H, many of the patients who had either stable disease or a partial response (PR) ended up with complete response (CR). However, it was an average of about 24 to 26 weeks before they had better responses. Some of these benefits can be seen earlier, but they also accumulate with time. Many of these patients may end up with a CR or a very solid PR after 6 months on the therapy.
In that study, pembrolizumab had 3 cohorts. The first cohort was the MSI-H CRC cohort. The second cohort was non-CRC with MSI-H. The third cohort was microsatellite stability (MSS). The MSS cohort had 0% response or 0% benefit. There was no control arm.
The 2 arms that seemed to benefit were the non-CRC and the CRC arms with MSI-H. Many of these responses that were seen in the CRC arm were very impressive, even more so than the non-CRC arm. The patients with pancreas cancer, endometrial cancer, and other forms of cancer, which is at a lower baseline of MSI-H than CRC, had even more pronounced responses that happened earlier.
Across the board, at least with pembrolizumab, our accumulative knowledge is that patients with MSI-H tumors will have a high likelihood of response or benefit from the application of pembrolizumab.
With nivolumab, our only experience so far is with CRC. There was a study that looked at the effects of nivolumab plus the CTLA-4 inhibitor ipilimumab (Yervoy). That led to an additional approval for nivolumab, similar to pembrolizumab, in MSI-H CRC tumors. In this study, we saw similar benefits with nivolumab in MSI-H CRC. When adding ipilimumab to nivolumab, there seems to be a trend towards improving the likelihood of response, but the toxicities were much worse.
The question as this study continues is whether there is a true benefit to adding the CTLA-4 inhibitor. It's toxic, expensive, and the likelihood of response doesn't appear to be significantly better. Although the trends are there—taking into perspective the toxicity and the cost—one would question whether this is going to be a viable option.
At this point, we need to wait for the study to complete before we arrive to any conclusions. What's clear for patients with MSI-H tumors is that there are 2 options—pembrolizumab and nivolumab. For all other non-CRC tumors that are MSI-H, pembrolizumab is the only FDA-approved drug.


text:
Magnatag InSight
The whiteboard and how it helps us brainstorm, innovate, motivate and create
How Do You Design a Hybrid Workplace?
How To Turn Your Wall Into a Whiteboard
The Secret To Perfecting Sales Territory Mapping
Creating a Dedicated Space For Project Management
Are All Whiteboards Magnetic?
The Ultimate Guide to Whiteboard Mounting Brackets & Tools
Factory and Production
GSA, Government and Military
Healthcare and Hospitals
Magnets and Supplies
Whiteboard / WhiteWall®
Whiteboards For The Home
The Best Dry Erase Board Games Ever, And How To Play Them
By: Tom Shaw
What Else Can We Use Whiteboards For?
Sure, whiteboards for businesses have many uses, but they can also be used for fun inside the classroom. Part of the reason why whiteboard games are so popular is because of the challenge involved with keeping students engaged in lesson plans. According to many education experts, introducing some form of activity within your classroom can boost student engagement, concentration, and retention skills.
There are dozens of classroom games you can play with your students that only require a dry-erase board, a marker, and a little bit of creativity. We've put together this helpful list of whiteboard games to help detail some of our favorites that can be enjoyable for both students and teachers alike.
Some of the Best Whiteboard Games for Kids
Earthquake – This is a classic trivia game that is easy to play and will undoubtedly be fun for everyone in the classroom. To play 'Earthquake,' grab your marker and draw a grid on the whiteboard that is 5 by 5, labeling each column with the letters A through E, and each row from one to five. Each square will have a question in it, a question that students won't know until they actually pick a particular score; however, it's important to remember that before starting the game, the instructor must secretly pick three squares on the board that don't have questions. These squares will be known as 'earthquakes,' where students will lose points for selecting that square.
Win, Lose or Draw – If you like to draw, then this game can be a blast for everyone. To play, a student is to draw a picture while the other students take guesses as to what is being drawn. Whoever can guess correctly gets the point and is up for drawing the next picture!
Jeopardy – One of the longest-running television game shows in history can also be played on a whiteboard. Students will have to really think and use the knowledge they have learned to score points. To play, divide the whiteboard into columns to designate spots for both vocabulary categories and point value rows. From there, divide everyone into two teams, with teams selecting a category and a point value. They will be given a clue or definition and must give their answer in the form of a question, just like on the show.
Hangman – One of the simplest, yet most classic games is Hangman, and its simplicity makes it a great whiteboard game. To play Hangman, lines will be drawn out in a row, to represent blank letters and words. Students have to guess letters, and for each correct letter guessed, they will be an inch closer to figuring out the word or phrase that they've been given. However, students don't get that many chances to guess the correct letters. Students will have approximately six chances to figure out the mystery word or phrase!
Super Egg – This is another highly educational game where two eggs are drawn on the board, and then each is divided into six sections. The instructor asks questions, and if a team gets the answer correctly, then they're allowed to color in one of the six sections of the egg. Once their egg is completely shaded in, they can draw whatever they like, imagining that it hatched from the egg!
Tic Tac Toe (Trivia Edition)–Everyone knows how to play tic tac toe, so this game is sure to be easy to pick up for all ages. To start, split your classroom into teams of four, and organize said teams into a March Madness-style bracket. Next, draw your traditional 3 x 3 tic tac toe grid on your whiteboard and bring the first matchup of teams to the front of the classroom. Each team will take turns answering trivia questions that relate to your current curriculum. If a team answers a question correctly, they can then place their move on the tic tac toe grid; if a team answers a question incorrectly, they have to skip a turn. Repeat the process until your bracket is complete and crown the champion!
Hot Seat– Start with two students facing the front of the classroom with their back facing the whiteboard and divide the class into halves with each half having one student in the front of the room. Write a vocabulary word, phrase, or important date in history on the board. After both teams have taken time to read, understand, and clarify what is on the board with their team, set a timer for one minute. Once the timer begins, teams must describe the word to the student with their back to the board without directly saying it. If the student at the front of the classroom can guess correctly, their team gets a point. Select a new student from each team to sit in the hot seat and repeat.
Pictionary– Make your own game of Pictionary using your own curriculum. Split your classroom into multiple teams and divide your dry-erase board accordingly so that each team has its own place to draw. Meet with each team's artist and share the card that they will need to sketch. Set a timer for one minute and allow teams to guess what's being sketched. The first team to guess correctly gets a point.
Whiteboard Scrabble– This game works best in a smaller classroom setting. Start by bringing one student to the front of the classroom and ask them to write a vocabulary word on the board and recite its definition. Ask another student to come to the front of the room and write and define another related vocabulary word that branches off the original. Students receive a point for each word they can branch off an existing word. However, if a student can't define the word, they only receive half a point.
Dots and Boxes XYZ– This version of dots and boxes requires students to be able to solve three variable equations and requires teachers to have access to at least two different colored dry-erase markers. Start by drawing both a 4 x 4 array of dots on your whiteboard, followed by a three-variable algebra equation off to the side. We've left one below for an example:
x−2y+3z=7
2x+y+z=4
−3x+2y−2z=−10
The 4 x 4 array of dots will create a series of boxes, which you should fill with variables that include X, Y, and Z (for example, one box may contain 2Y, and another box may contain X-3, etc.) These variables will serve as mini equations that dictate the number of points awarded for a completed square. Split your classroom into two teams, give each team one of the colored dry-erase markers, and task them with solving the equation on the board. Once both teams feel confident in their answer, the game will begin. Each team will take a turn connecting two lines on the matrix. Once a box has been filled in, the team that filled in the final line is awarded the points within the box. Play until the last box has been filled. Allow each team to tally their points, review the equation as a class, and then award a winner! You can learn more about XYZ dots and boxes using this PDF Download
Are there any creative whiteboard games that you've played or can think of? Share them with myself and our readers in the comments section below!
Categories:Schools and Education