If you're short on time, Niagara Falls can be conquered in half a day. No need to sweat it; the best attractions will be yours to see throughout those short hours you have in the area. First things first, park your car anywhere you find a spot (following any parking restrictions), take a stroll down Clifton Hill and go on The Maid of The Mist to really take in the majestic nature of the Falls.
Visitors that love a little adventure fall in love with The Maid of The Mist tour as it really showcases the beauty of the Falls, a massive wonder of the world. Snap some photos of the Falls near and far, then once you've seen just as much as you think you can handle, head back up Clifton Hill, pop into a wax museum or two, grab a bag of candy from The Hershey Store and then take to The Niagara Skywheel, one of the best attractions on Clifton Hill.
One of the lovely things about The Skywheel is that you can enjoy a ride on this huge ferris wheel during the hot summer days or cold winter nights as each enclosed gondola has heat and A/C within it. Stop off at Antica's Pizzeria after you've exhausted yourselves on Clifton Hill. This wood-burning oven pizzeria offers some of the best pizza in town. With individual thin-crust pizzas, topped with anything and everything under the moon, this Italian restaurant is a favorite among many.
After lunch, hop into your car and head off to The Butterfly Conservatory or The Fallsview Botanical Gardens. What many come to realize while they spend the afternoon in Niagara Falls is that there is much more to see than your traditional attractions. If you have a love for exploring unique spaces, then The Butterfly Conservatory will become your new favorite destination. Better yet, take a stroll through Niagara's famous Botanical Gardens where you'll certainly fall in love with overflowing rose gardens and perfectly manicured trees.
Finish your day off at The Whirlpool Jet Boat Tour where adventure meets excitement in more ways than one. Jet boat through the Niagara River and embark on an adventure like no other; your adrenaline will be rushing all the way home. Niagara Falls has much to offer visitors from around the world, and if you're only here for half a day, there are sights to be seen and photos to be taken, so take to the streets and enjoy all the eclectic beauty that Niagara Falls has to offer.
If you're looking for a real rush, take to Melaina's favorite adventure: Niagara's Whirlpool Jet Boat Tours.


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Home » Country Artists » Luke Bryan » Luke Bryan's Mom Tried to Do the Splits in a Swimsuit and a Family Vacation Has Never Been Funnier
Luke Bryan's Mom Tried to Do the Splits in a Swimsuit and a Family Vacation Has Never Been Funnier
Lisa Konicki
It must run in the family. We know their sense of humor does. Luke Bryan and his mom, LeClaire, had a few mishaps on the beach while enjoying a little downtime on a family vacation. Lucky for us, Luke's wife, Caroline, caught it all on camera.
While on the beach, Caroline catches LeClaire trying to do a split in the sand. Luke's mom certainly is a hoot. If you recall, she recently got run off by some Geese ,while trying to feed them and Caroline caught that all on video too. We're starting to see a pattern.
This time, LeClaire manages fall face forward into the sand while getting into the split position, as her grandchildren and daughter-in-law egg her on. The words "Mamaw, do a split!!!" are written on the Instagram story.
While mom Bryan tries to get down low, and we give her major points for even attempting a split, it doesn't end up going so well.
"This is even better with Luke in the background," Caroline says as she films her mother-in-laws split attempt. If you look closely you can see a tiny Luke trying his hand at surfing amongst the waves.
But wait, in the next video, Caroline catches Luke crashing and burning as he attempts to catch a wave and ride it back in.
"I want Luke to bust his ass again. I'm just keeping the camera on and I'm waiting for it," she says. And he does. As soon as Luke gets up on the board a wave comes and knocks him right off. The superstar then turns to the camera and throws his arms up.
We'll give him an A for effort. There's always the next wave. And hopefully, a next video from Caroline soon.
beach, caroline bryan, family vacation, LeClaire Bryan, Lukes mom, Split, Surfing

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Hamden Fire Retirees Association, Inc.
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Horrible Lightning Tragedy on West Shepard Avenue
On the Fourth of July 1950, a freak lightning strike killed three and injured several others outside the 65 West Shepard Avenue home of Mr. and Mrs. Leonard A. Dorman, where the organizational meeting of the Mix District Volunteer Fire Co. No. 7 had taken place in November 1924.
The occasion was a gathering of family members and friends to celebrate the birthday of the Dormans' son, Leonard E. Dorman, 20, who was among the injured. The younger Dorman had been a member of Mix District Co 7 since 1945. Also among the injured was the late Frank Warner, then 26, also a member of Co. 7. He reported that there was no indication of storm activity in the area. The lightning strike was totally unexpected.
The Hamden Fire Department responded under the command of Capt. Everett Doherty. According to details provided in the Hamden Chronicle article below, a chain hanging from a nearby tree conducted the fatal electrical charge.
This was one of Hamden's earliest mass casualty incidents on record. Police, fire and ambulance personnel worked valiantly to render assistance to the survivors. Rev. Joseph Peters of the Mt. Carmel Congregational Church also responded to render spiritual support to the surviving family members. Three months later, Rev. Peters would be appointed with Fr. Bernard Miller, assistant pastor at St. Rita's Church, as one of the first two chaplains of the Hamden Fire Department.
In the years that followed, this tragic incident was often cited in local warnings for people to avoid standing beneath trees during electrical storms.
Posted 7/3/15
Revised 8/16//15
The Hamden Chronicle, July 6, 1950 (Courtesy of the Hamden Historical Society)
Capt. Everett Doherty started his career on the Hamden Fire Department in late 1927. He retired in 1966 at the rank of deputy chief. Lt. Paul Leddy was appointed in November 1941. He was promoted to lieutenant in 1949, captain in 1951 and named battalion chief in 1954. In November 1960, B/C Leddy was appointed Chief of the Department, a position in which he served until his 1984 retirement.
Lt. James Strain was appointed in 1942, became a lieutenant in 1949, captain in 1954 and deputy chief in 1961. He retired in 1973. Firefighter Francis "Chalkie" Leddy was appointed in 1946, was promoted to lieutenant in 1956, captain in 1964 and deputy chief in 1970. He retired in 1986.
Firefighter Fred Fletcher was appointed in 1946 and retired in 1980. Firefighter Dan O'Connell joined the department in 1948 and was promoted to lieutenant in 1963. He retired in 1986. Co. 5 volunteer firefighter Joe Rahl joined the department as a career member in 1956. Joe served 33 more years before his retirement in late 1989. Joe, who turns 91 this year, is the only surviving member of the crew mentioned in the 1950 article. He is currently a member of the Hamden Fire Retirees Association.
CLICK HERE: What to Do in a Lightning Storm | Fox News
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You can not order from einglish site now.
All our products are imported. We have lot of Japanese products,too.
Especially, Italian Koshihikari "Yumenishiki Rice" is our recommended product!
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We can also deliver to around Zürich or to other cities with free shipping.
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We are selling Hiro Takahashi's Japanese Breads and Cakes.
We don't send frozen- or cool products. You can pick up here or we can meet at convenient place for eachother.
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Baseball Hall of Fame voting history for the Colorado Rockies, 1993-2021: Part One (Bichette, Burks and more)
By Patrick Lyons January 17, 2022
Two days before the first game in franchise history, the Colorado Rockies signed a player many believed would be their first member of the Baseball Hall of Fame. Dale Murphy was released by the Philadelphia Phillies in the early hours of April 3, 1993 and was just two home runs short of 400 for his career. (At the time, only…...
Unsung Hero: Díaz does it all in season rarely seen from a Colorado catcher
By Patrick Lyons October 29, 2021
Steve Reed represented the Colorado Rockies through their first five seasons of existence and pitched in more games than any other for the franchise, spending half his 14-year career in purple. His 140 ERA+ is often overlooked, and remains a staggering figure during era pitched mostly before the advent of the humidor. Steve Reed Award for Unsung Hero Elias Díaz…...
Rockies Review: May 16-17, Holliday hits way to historic 2007 season and other weekend wingdings
By Patrick Lyons May 17, 2020
Before Game 163, when Matt Holliday hustled home on a shallow sacrifice fly ball to help clinch Colorado's first spot in the postseason in eight years, the star left fielder did a lot for his club in 2007 leading up to the controversial play. Holliday's value that season was prevalent through the 162 games leading up to the critical matchup…
Rockies Review: April 27, 2001 – Pérez punctuates era with start of streak
By Patrick Lyons April 27, 2020
Long before Trevor Story (2016-present) occupied shortstop for the Colorado Rockies, there existed an era between that of Walt Weiss (1994-97) and Troy Tulowitzki (2007-15). Neifi Neftali Pérez (1998-2001) signed with Colorado as an international free agent at the age of 18 before his organization ever took the field in 1992. So long ago that he plied his trade in…
Rockies Review: April 18, 2001 – Hampton and Neagle toss rare back-to-back shutouts
When the Colorado Rockies did not sign even one major league free agent this past offseason, it was a reminder they had once invested $172.5M in two starting pitchers. It was December of 2000 and less than three years later, neither would be seen in purple pinstripes ever again. Mike Hampton (eight-years, $121M) and Denny Neagle (five-years, $51.5M) were signed…


Futurist Mike Walsh is always ahead of the curve. In this video from a recent keynote, Mike shares the next big change coming in AI – it's all about how we interface with technology where our interactions will be entirely natural. Watch this video on how China is an amazing example of AI technology in daily life.


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Home Money, Politics and Power Everybody Hates Mitt
Everybody Hates Mitt
This time, it's personal.
A new e-book from Glenn Thrush and the folks at Politico contains this interesting tidbit concerning Barack Obama's feelings about Mitt Romney:
"One factor made the 2012 grind bearable and at times even fun for Obama: he began campaign preparations feeling neutral about Romney, but like the former governor's GOP opponents in 2008 and 2012, he quickly developed a genuine disdain for the main. That scorn stoked Obama's competitive fire, got his head in the game, which came as a relief to some Obama aides who had seen his interest flag when he didn't feel motivated to crush the opposition. Obama, a person close to him told me, didn't even feel this strongly about conservative, combative House Majority Leader Eric Cantor, the Hill Republican he disliked the most. At least Cantor stood for something, he'd say.
"When he talked about Romney, aides picked up a level of anger he never had for Clinton or McCain, even after Sarah Palin was picked as his running mate. 'There was a baseline of respect for John McCain. The president always thought he was an honorable man and a war hero,' said a longtime Obama adviser. 'That doesn't hold true for Romney. He was no goddamned war hero.'"
A brief digression: as John McCain taught America, you can be a war hero and also be a jerk; the latter doesn't subtract from the former. But McCain is the one politician who is always defined by the most admirable thing he ever did, even though it happened four decades ago, while most politicians are defined by the worst thing they ever did. In any case, assuming Thrush's reporting is accurate, it's interesting to see the famously cool and detached Barack Obama actually displaying emotions.
It's a reminder that politicians, even presidents, are human beings. If someone was going around the country every day telling anyone who would listen that you sucked at your job, and not only that, you also don't really understand or believe in America, you'd have to be the Dalai Lama not to decide that that person is, down to his very core, an asshole.
Of course, Mitt Romney is a special case. As Kevin Drum says, "something about the presidency seems to have brought out the worst in him. His ambition is so naked, his beliefs so malleable, his pandering so relentless, and his scruples so obviously expendable, that everyone who spars with him comes away feeling like they need to take a shower." The fact that Romney hasn't given us much reason to like him means there's nothing to counteract the negative reaction we have to the awful person he is as a politician. Different candidates are able to do this in different ways. With Barack Obama it was his inspiring personal story, with McCain it was the war record, with George W. Bush it was his easy-going, friendly manner. The result is that even when we see them engaging in some campaign hardball, we're able to tell ourselves, "OK, I didn't like that much, but I realize that he's basically a good guy."
Romney doesn't have an inspiring story (feel your heart flutter at "Son of wealth and privilege grows up to obtain even more wealth and privilege"), and his manner is, shall we say, strained. There have been occasional attempts to use his wife Ann and sons, the interchangeable Tagg-Craig-Turf-Gorp or whatever their names are, to humanize Romney, but it never seems to get very far. So when he makes up things about his opponent or refuses to tell us how much money he has or what he does with it, there's nothing on the other side of the character scale to counteract the impression voters are left with. The person he is as a candidate is all anyone can see. And that person is pretty repellent. So it's no surprise that his favorability ratings are extremely low and probably going nowhere but down.
Blog: Vox Pop Paul Waldman Politics Election 2012


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Q: printing rdlc using report viewer 10.0.0.0, print button not showing I have an rdlc report in an asp.net project.I'm using report viewer 10.0.0.0 to view and print the report. Except for Internet Explorer the print button of the report viewer does not show.
Though in my case, print button does show in IE, it gives the error" Unable to load client print control"  when it is pressed. I found similar problems reported for report viewer 2008,but the solutions like, installing the SP 1 did not solved my problem.
Is there a way to enable printing independent of the browser?
Please Help.

A: You can add your own button and adjust it to the report header and, using jquery and javascript you can print from chrome or firefox
For direct printing on page load:
$(window).load(function() {
var a = document.getElementById("ReportFrame" + reporviwername).contentWindow;
    a[1].print();
});

For printing on PrintButton click:
$('.PrintButton').live('click', function() {
    var a = document.getElementById("ReportFrame" + reporviwername).contentWindow;
    a[1].print();
});

A: The printer controls in report viewer are implemented as an ActiveX Control. Those are IE specific controls. So, you will not get that option if you use anything other than IE.
If you want a browser independent version, you could embed the report in pdf form.
Pdfs viewers have  a print button.
In my experience it works well with most modern browsers. The pdf format too is standard, so your reports will be printed the same, regardless of the browser.

A: As everyone suggested that Report viewer control only renders with ActiveX control, and many other browsers don't support this so not possible but IE.
So Microsoft updates their supporting features in a recent release after SQL Server Reporting Service 2016 and later version they have updated their dependencies on ActiveX Control.
So you can update your Reporting Services to Latest.
Refer :Updated Report Viewer Control

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text:
Vitis bloodworthiana är en vinväxtart som beskrevs av B.L. Comeaux. Vitis bloodworthiana ingår i släktet vinsläktet, och familjen vinväxter. Inga underarter finns listade i Catalogue of Life.

Källor

Externa länkar

Vinsläktet
bloodworthiana

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Chen Xiang knew that Yuan Feng and the others had gone to the Evil G.o.d Mountain to cause trouble, but he never thought that it would be settled so quickly.
"Don't call me Natural Law Divine Spirit, I'm Yuan Feng now. Old Qian, are you enjoying your life now?" Yuan Feng walked into the study room and laughed.
"I'm Yuan Xin!" Yuan Xin cupped his hands towards Great Landlord.
"Wan Yuxiong!"
Great Landlord looked at Chen Xiang, as if he understood what was going on.
"Alright, how did you manage to escape the restraints of that kind of power?" The Great Landlord said.
The restrictions on the Great Landlord wasn't that strong, but it prevented him from being promoted and he couldn't leave the Natural Law World. That was why he had been trying to find a way to do so these past few years.
Now that he saw that Yuan Xin and Yuan Feng could get rid of them, he really wanted to know why. He had also went to find Du Xiaoling and had asked him to help him before, but he couldn't succeed.
"That brat helped me. If we didn't suddenly get dragged into the Heavenly Evil Abyss, he would have come back to help you." Yuan Feng laughed.
Chen Xiang took out a few pills condensed from Primitive Tao Power and threw them to Great Landlord, saying: "This is the pill they are using!"
The Primitive Tao Power was extremely hard to obtain for the people here, but Chen Xiang had an endless number of them.
"Primitive Tao Power... This is a pellet condensed from the Primitive Tao Power! " Great Landlord's body trembled, his body was shaking, this was too rare for him.
And the seal within his soul, required a large amount of Primitive Tao Power to be unsealed!
"This kid has Primitive Tao Power all over his body, if not he would not be so terrifying. I really don't know how he cultivates." Yuan Feng sighed.
"I am a Alchemist … When I was cultivating the Gate of Heavenly Mystery, I collected a large amount of Primitive Tao Power from those Black Hairs Human s and then used my alchemy skills to refine a pellet that contains a large amount of Primitive Tao Power. After consuming the pellet, I would cultivate up to the Primordial Profound Gate and then have an endless supply of Primitive Tao Power. " Chen Xiang laughed.
Hearing Chen Xiang's words, the Great Landlord thought about it carefully and then shook again, "I remember that your profound door was completely opened. If you use the Primitive Tao Power to pa.s.s through the profound door, then wouldn't it be very strong …? "No, it requires a very strong physical body. Could it be that your physical body is also very strong?"
Chen Xiang smiled and nodded: "Now, all I need to do is cultivate my Dao G.o.d soul to the Great Perfection level and I will be able to step into the Dao G.o.d Stage."
Great Landlord sighed and nodded: "You know how to refine such a strong pill, that's how great it feels!"
"Oh right, what conditions do you need to go to Divine Wasteland for?" Chen Xiang asked: "Although our current strength can suppress the forces of evil, but if we do not take care of it completely, we will come back in the future."
Everyone here understood what Chen Xiang meant. If they wanted to solve the problems of this world, they had to go to the Divine Wasteland and kill the only person that was in charge of this world!
Killing Natural Law Divine Lord required a lot of strength, but Great Landlord felt that Chen Xiang was qualified!
"To go to the Divine Wasteland, you have to first wait. Wait patiently until the moment of solar eclipse. At that time, you can open the tunnel and enter the Divine Wasteland." The Great Landlord said: "Although we can enter from the Myriad G.o.ds Abyss, that road isn't easy."
"That's right. When I first came down, I was already half-dead and had yet to recover. So I had no choice but to not take the Myriad G.o.ds Abyss route." Wan Yuxiong said.
Great Landlord still doesn't know Wan Yuxiong's ident.i.ty. He looked at Wan Yuxiong curiously, and Chen Xiang immediately introduced him to Wan Yuxiong.
"Looks like we'll have to wait for now." Chen Xiang said: "That's right, I am only a Dao Lord now, can I go to Divine Wasteland?"
"With your strength, this shouldn't be a problem." Great Landlord said, "But … You need to understand clearly that when you go to a world of higher levels, you will always be at the middle and lower levels. "
Wan Yuxiong understood this point very well, and said: "It is indeed so, but you don't have to worry. The Divine Wasteland is also filled with powers, you can just find someone to rely on, and at that time, I will go with Chen Xiang."
"Alright, while we wait for the eclipse, let's clean up the evil forces here." Chen Xiang said.
"Leave it to us!" Yuan Feng laughed: "Anyway, I have been very idle these days."
Yuan Feng dragged Wan Yuxiong along with him and went to find the evil forces to destroy everything. If he couldn't beat them himself, Wan Yuxiong would help him.
Great Landlord would go into seclusion to refine the Primitive Tao Power Pill!
Under Yuan Feng's guidance, Chen Xiang found the island his father was on.
Shen Tianhu was the Island Master now, so he managed this island well. Furthermore, the power of the Island Spirit was becoming more and more terrifying.
Previously, Feng Yujie was the one who brought Chen Xiang here, and later on, Feng Yujie himself came many times, as he came to collect medicinal ingredients.
"This island is very stable now, not like how it used to be!" Shen Tianhu entertained Chen Xiang. He was Chen Xiang's father, so Feng Yujie and the others frequently brought pills here. Therefore, Shen Tianhu's cultivation was also very high.
"Dad, your life is pretty good. This island is so magical. It's almost like a kingdom, and it can fly all over the place. The plants here can grow quickly." Chen Xiang laughed.
"Brat, is Yu Jie really your woman? Does Xianxian have any objections? " Shen Tianhu asked softly. Because the people on the island did not go out much, Shen Tianhu did not really understand much about the matters outside, especially the matters regarding Chen Xiang.
"That's what she told you?" Chen Xiang asked.
"Yes!" She brought a few girls and called me daddy. They are all so beautiful, did you use some underhanded method? " Shen Tianhu drank the wine with a face full of doubt.
"No, you don't have that much confidence in your son?" Chen Xiang curled his lips.
"Hehe, looks like this is true? But then again, you have so many women, why don't you have any children? " Shen Tianhu continued: "It's been so many years, I really want to hug my grandson!"
Chen Xiang picked his ears and laughed: "Father, what are you so anxious about? "It's not a peaceful time right now. Wait till I settle down. Hehe, I'm worried that you won't be able to come over with me when you carry me."
"With these words of yours, I can feel at ease!" Shen Tianhu laughed.
Chen Xiang took out some medicinal ingredients and told them to give them to Shen Tianhu to grow. All these years, the Pill Fragrant Garden in Hundreds of Flowers Village was created because of the large amount of medicinal ingredients obtained from there.
Only now did he return to the Hundreds of Flowers Village to look for Xue Xianxian. Every time he returned to the Hundreds of Flowers Village, he would first go find Xue Xianxian and the others.
"You Qing, this girl, she has created so many curse traps!" Chen Xiang accidentally stepped on a trap and his leg became a block of wood. Luckily his Primitive Tao Power was strong enough to directly force out the curse.
"I knew you would come at this time." Xu Youqing walked out of the house, and laughed: "This is I trying to test your little test!"
In the past, the moment Chen Xiang entered the courtyard, he could feel the busy atmosphere. But this was not the case now, as he had seen several women quietly reading in the hall, he did not know what they were reading.
Chen Xiang took out the Emperor seal s, wanting Xue Xianxian and the others to study them and see what secrets they were hiding.


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Let's review this past devilishly whacky week to see if we can divine the way the world is turning and why the markets are churning. It was 2019's worst week in stocks and, well, just about everything economic all across this crazily spinning planet. Volatility lifted its head back out of the water like Loch Ness's monster while the citizenry took flight to treasury safe havens, bringing treasury yields down again to the five-year's lowest point of the year. North Korea's Rocketman returned to his rocketry, and the Chinese threw up their hands and ran as far from Mar-a-Lago as they could … or maybe they just threw up from too much chocolate cake.
Most notably all over the world, bad news finally moved back to just being bad news, even as it arrived in cloudburst after cloudburst. Gold popped as money dropped and China flopped. Chinese exports fell 20%, outstripping the worst prediction four fold. The central bank of the billions of people of China mainlined major yuan jolts into the Xi dynasty's tiring economy, and yet the Sino stock market fell off the mountain, taking a full panda bear plunge in one week. Apparently the nouveau riche Chinese ghost-city dwellers are wising up to all this easing and just realized talk of more of the same as far as the eye can see simply means the economy is finished more than it means refreshed hope waits on some distant horizon.
Trump talked and China walked. The best boast Trump could biggly bluster from his tweet blaster was that the stock market would rise again if China would only deal; China chose, instead, to cancel Chairman Xi's second coming at Mar-a-Lago. Most market makers are saying the Chinese trade wars now have more downside than upside. Markets have priced in Trump's repeated wafting of wistful hopes that a deal will be struck any day. His twittering about had the lightness of ether this week. If it happens that China does sign a grand bargain, the market money is already riding on that deal, so it won't bring a lot more lift. If it doesn't happen, on the other hand, the table cloth gets pulled out from under the Mar-a-Lago gold settings, and one can only hope all the crystal doesn't shatter as Xi xings away without his chocolate cake.
The European Central Bank joined all other major central banks in twirling away from the tightening it had just promised and rushing back to renewed rounds of easing via mega loans to banks because it got schooled in a hurry to the awakening that it cannot everunwind its balance sheet. It made this stunning pivot when reality forced it to admit the European economy is stalling. The ECB forecast prerecessionary growth of just 1.1% for 2019. To finish the dance, reports came in after Chairman Draghi's announcement that some ECB thinksters didn't think their central bank downgraded the economy far enough!
And, so, the bank that once promised it would do anything to save the Franco-German Empire will return to doing what hasn't worked so far. As happened in China, this new round of promised profligacy was not greeted with the now customary market ecstasy. Exasperated European investors dwelled, instead, on what the ECB's flash reversal revealed about Europe's economy.
And, so, the old regime returned in which bad news is just bad news. It was almost as if exhausted investors felt Central Bankster Draghi's sudden ankle twist indicated central bankers are clueless since only a couple of weeks ago Draghi was boldly certain his central bank needed to torque up financial tightness. Suddenly, he and his bankster troop were break dancing on their bonnets in the streets of Belgium.
"It may be several meetings of the Federal Open Market Committee before Fed policymakers have a clearer read on whether the risks are becoming reality, and by how much the economy will slow compared to last year," said Rosengren in his speech. He added that "patiently watching" is the best policy for now.
Notice the shift to figuring out how much the economy will slow, rather than worrying it may start to run too hot, which required full-blast quantitative tightening up until December. These guys know what they're doing!
Vice Chair Richard Clarida … stressed "cross currents" and "head winds" are strengthening.
Substantial growth in BBB and lower-rated bonds is indicative of a weakening in corporate credit quality in the U.S…. which sort of reinforces, for me, why I feel we should be taking no action for some period of time.
So, the central choristers sang as the high-stepping Fed heads joined Draghi to spin in the streets of their financial capitals, but the citizens watched in stony silence at their odd and globally united parade. All this market hopium gave no high anywhere. Stocks did nothing but fall, fall, fall, which would seem to confirm Jerome Powell's candidly stated concern last month that people are losing faith in big institutions … by which he seemed to mean central banks.
Is there anyone who would ever have thought more rounds of quantitative easing would be less effective this time around because the Law of Diminishing Returns still rules? Oh, yeah, me … right here all along.
To cap this capricious week of chaos and carnival, one of those once-a-year flukey jobs reports cruised in under the radar at a mere 20,000 new jobs, smashing far below the lowest expectations of the gloomiest, doomiest prognostications of 150,000.
As if that were not enough rain on the parade, all hail broke loose that same day when the US budget deficit took a rocket ride to the moon. That is to say, it was reported that day that the US deficit vaulted into the heavens in a whopping 77% ascension in the first four months of this fiscal year — another Trump triumph. He ordered the tax cuts, and he ordered the spending increases, so he gets to own it.
With the greatest revenue boosters now receding in the rear view mirror and GDP fading smaller and smaller each of the last two quarters, it doesn't look like those tax cuts will ever be paying for themselves. The Fed made that definitive by forecasting an even bigger GDP plunge this quarter to a 0.3%-0.8% lowland that makes Europe look great again. So, we can reverse the Trump Tax Cuts to restore fiscal responsibility, too, or just spend ourselves into oblivion because the interest alone is now pushing half a trillion dollars. Half a trillion here, and half a trillion there, and pretty soon you're talking real money. "Don't worry," the Debt Drifters will say, "It's only money; we can always print more" — the new money theory of the nuevo-socialista Democrats that I'll be attacking into in new articles soon.
With socialists rising all over the nation to preach infinite money creation — Sanders, AOC, Warren, and the Fed, which socialized all the losses of the capitalists with nuevo money — and with Democrats voting to give illegal Russian aliens the right to vote in US local elections if the locals so choose (even as they decry Russian interference in US elections) and with an habitually anti-semitic congress woman in hijab now being excused by ranking (and just plain rank) Democrats for her relentless rants about "Benjamin-seeking" Jews, I think the world is doing a whirling dervish on its axis right now.
My country has become as crazy like an asylum on parade. But, hey, the end of next week brings us into the Ides of March when all debts were settled, the Roman pantheon was worshipped and caesars were killed, ending the crisis of the Roman Republic and triggering the civil war. So, let's raise a glass of Italian whine to the fact that, even when things are this crazy, they can get worse!
General Motors mothballed one of its Ohio factories this week, and Dollar Tree announced it will be closing several hundred stores even as clothier Charlotte Russe announced closure all of its stores with immediate liquidation of all inventory. The Gap said during its earnings report it will be shuttering 230 stores. Victoria's Secret said it will be stripping off 53 of its North American boutiques.
And, yet, there are idiots out there who keep crowing that the good times are really on a roll now. After all, we just had a fantastic bear-market rally, now ended. How could it be better?
Let them dance over the cliff with their bankster band leaders.
If you're looking for the reason stocks fell relentlessly this week, how about all the above? The quants can have their numbers; the chartsters can charter away, but reality carries the day.
The S&P 500 slipped back under its 200-day moving average. The Nasdaq nodded the same. The S&P Buyback Index, which tracks all the stocks that are rising in the S&P due to buybacks actually fell harder than the overall index. The Nasdaq FAANGs fandangled below their 200-day running average, too.
I wouldn't make any prediction based on an eery chart coincidence, any more than I'd claim Ivanka Trump's husband is the antiChrist just because his business address is 666 Fifth Avenue; but it's still fascinating! Especially in a world gone weird. Twain said history rhymes; today we might say it is comprised of fractals of peculiar coincidence.
Best-case scenario, the two lines converge in the middle at 2350 where the S&P last found its bottom.
The Dow transportation stocks matched an ancient record of badness this past week. Their eleven-day fall paired up to their worst losing streak since Watergate. If you're a Gen X-er, you may never even have heard of that. There was this guy with a shoe-shaped nose named "Nixon…." Well, never mind. It was a bad time far in the rearview mirror that looked … well, increasingly like the present time. The fall of a president shook the nation to the core of its being.
Important to note: The Dow transports are not stocks that merely show us how the rest of the stock market is falling. This 135-year-old index is the canary in the coal mine. The "trannies," as they are lovingly referred to by gender-neutral marketeers, reflect the entire condition of the industrial world in America. They trannies go down when the closing of thousands of stores reduces shipping and when Trump Tariffs drag imports and exports down to stall speed, and when housing construction slows, which slows the movement of all kinds of materials, and when global economies start lurching like an auto out of fuel. They go down when the economy stops moving because they are the movers of all things real and not virtual, and boy have they gone down, hitting their worst path in half a century.
2019 also turned out to be, inspire of all its market madness, the year of capital flight from the US stocks. Well, I guess that is the mark of its madness. Yes, you heard that right. Even though stocks were bid toward their former heights throughout the first two months of the year, more money flowed out of the US market than flowed in throughout that same time. Apparently nobody with big money believes in this rising market.
Money kept leaving at the same pace, even though the market returned to rising. When the market finally reached the S&P's triple-tested 2800 ceiling for a fourth attempt and skidded along the bottom of the ceiling to finally lose lift and drop back away, the fleeing investors proved right. Exactly how the market rose so much with so much money fleeing, I never found a good explanation for — prices going up almost equal and opposite to the money going out.
But, like I said, It's a weird and whacky world.
While the bears prey, let the bulls pray that the S&P 500's last 2400 bottom holds because the next sturdy stop for chart dwellers is between 2200 and 2100, taking out the entire Trump Rally; and after that, it's no-man's land.
No, that's not a prediction, but it is where this thing could fall for the simple reason that rallies based on hopium and the euphoric high it delivers when mainlined to the moon, have very little support stops along the way back down — either simple chart support or real fundamentals … especially real fundamentals. And those are my basis for saying this market has no support.
When the entire world is margined into the stratosphere on corporate debt, individual credit card debt, mortgages (including millions still hunkered in from the 2008 crash) stock margin debt, delinquent student debt, sovereign debts (all in a world of rising interest), falling earnings and falling stock buybacks, you can find as much downdraft as the sinking Titanic.
Or … everything could go right … just like the Donald says it will! All hail the chief! Well, it could!
Maybe this was just a week of blips, not of Freudian slips that are showing the true nature of the debt-addled economy through all the holes in the lacy veil that covers its stinking corpse. Maybe all is as golden as the Donald's showers, and China will give us a deal that makes the Trump Tariffs salutary, and the ECB will finally save the Euromess with reinforced rounds of easing, and Brexit will exit as smoothly and gracefully as the most refined Englishman can hope for, and the US stock market's last bottom will hold like a rock foundation as steady hands in the market hoist again the flag of hope. Maybe housing will find a second wind, and the Retail Apocalypse will hit a brick-and-mortar wall that stops it from mauling all of Americas malls, and automakers will retool to produce fleets of electric dreams, turning the auto market around in just a year to a bright new future. Maybe everything will go like your most golden dream.
And maybe the Beatles will regroup for a reunion from the land of the gratefully dead in a great yellow submarine piloted by a young Elton John to float across strawberry fields forever. Maybe. Maybe the world will turn a new page, this long tiresome trip to nowhere will end, and the troubles we never dealt with will just dissolve away in an opiated haze. Maybe. It's a wonderful whacky world, so anything can happen.


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SATURDAY NIGHT DEACON BLUE, THE UNDERTONES.
First Deacon Blue with Dignity, the single taken from their debut album Raintown (1987).
Scottish rock/blues band, formed in Glasgow in 1985. We will forgive them that bit about reading Maynard Keynes.
Then it's The Undertones with It's going to happen! Released as a single in 1981.
Blokes from Derry, Northern Ireland. Singer's Feargal Sharkey.
BILL WHITTLE ON AMERICA'S "GUN CULTURE".
Bill Whittle, eloquent as always, on America's supposedly violent "gun culture":
Yes, I know. There don't even have to be violent shootouts for fatalities. This week, our "quality" "press" almost gleefully reported on the death of a two-year old Floridan toddler, Kaleb Ahles, who fatally shot himself with a gun he had taken from a map compartment in his father's car. A very tragic accident.
Curiously though, that same "press" remained mute on the number of perfectly healthy foetuses murdered in the womb throughout the States in the same week. Perhaps the number is so high it's embarrassing even for leftists?
Or not? Because they considered the defeat of the pro life bill in Congress, despite the GOP controlling it on both levels, a victory.
Leftism is a mental disease.
Geplaatst door Michael op 10:40:00 AM 0 reacties
Labels: On Being Right
BREAKING!!! BELGIAN PM CHARLES MICHEL BRIEFS CNN'S CHRISTIANE AMANPOUR ON TERROR THREAT!
Fewst eppirens on di internesjenal seen four our nuw PI M, Charles Michel (MR):
Outlaw Mike sliips wel ad nite, tanks too da efisjent belzjian sicuriti fourcis!!!
VIVE LA BELGIQUE!!!
Labels: Belgium, Humor
MICHAEL MANNHEIMER'S SPEECH IN WUERZBURG.
Via our pals at Gates of Vienna.
In Wuerzburg, Michael Mannheimer is to Wuegida what Lutz Bachmann is to Dresden's PEGIDA. Of 183 children he recently counted in a kindergarten, just two were German. Mr Mannheimer claims that in Pforzheim, a city in Germany's west, in the Saar region, 90% of all children under three years of age are muslim, from 17 different countries...
... It might be. Two of the German transporters we regularly see are from Pforzheim. Both are in their early fifties and right before last Xmas, I found out that they were both childless. Don't give me crap about this anecdote being a statistical fluke, I know what the fertility is among German autochtons, and it is well below replacement level.
Anyway, listen to Mr Mannheimer:
I especially liked the part when the crowd is starting to chant "Luegenpresse". As a matter of fact, Belgium's own Luegenpresse par excellence, newspaper De Standaard, apparently had lots of fun this week with statements made by Steven Emerson on Fox News, in a debate hosted by Jeanine Pirro. Now it is true that Mr Emerson made the unfortunate comment that "There are actual cities like Birmingham that are totally Muslim, where non-Muslims just simply don't go in," - but the uproar that caused has definitely had a smokescreen effect on the very real substitution of Britain's autochton population by immigrants, and then especially muslim immigrants.
Of course Birmingham is not a muslim city. YET. But give it twenty more years and it MIGHT BE. That is the core tenet in Mr Emerson's story.
De Standaard is one of those newspapers willing to disperse such smokescreens, and if sufficient gullible readers are willing to be misled, what Emerson warned against WILL come true.
Labels: Islam in Europe, Islamic Cancer
AHMED ABOUTALEB AND EXTREMIST MUSLIMS: SAME GOAL, DIFFERENT APPROACH.
There's a youtube video gone somewhat viral of Ahmed Aboutaleb, mayor of Rotterdam and prominent Dutch socialist (the mainstream party PvdA, not the SP), in which he apparently admonishes young muslims who refuse to take for granted freedom of expression, telling them to "f*ck off". At least that's how most Anglosaxon commentators translate Aboutalebs "rot op", although "f*ck off" is actually harsher. A more apt translation for "rot op" would be "get the hell out of here!".
Aboutalebs not-unclear language obviously earned him the sympathy of many a western observer from all sides of the political spectrum. One of them is one of my favourite bloggers, CDR Salamander, whose naval-oriented blog I've been following since the beginning (2004, to be precise). The CDR has several often recurring topics, and a near constant are the FbF's - Fullbore Fridays. Posts generally dealing with personae or units having shown exceptional gallantry or military prowess. I've basically always agreed with his assessions of those selected - but I have grave issues with his last two choices. The first, ten days ago, was Egyptian General al-Sisi. Now, this man during a recent speech at al-Azhar university indeed said remarkable things - for a muslim. More on him, time allowing.
The second was Ahmed Aboutaleb, of "rot op" fame. CDR Salamander last Friday:
"The last week has seen a sickening parade of morale and physical cowardice in the defense of essential liberty. Afraid of what may happen if they stood with the French, politicians and much of the press instead hid behind "responsible speech" - which is their way of cowering in the face of threats against the very freedom they need to exist. That is the true Islamophobia - a twisted partonizing attitude that you cannot risk offending even in the slightest the tender feelings of a Muslim because, well, they just can't take it like everyone else and might become dangerous. A phobia of the followers of Islam: Islamophobia.
Heck, even last night I was reminded why I used think I was of the left. It used to be that there was a very libertarian streak on the left, but in the last 30 years they have been swamped by the Stalinists. One of the last of the traditional libertarian leftists I have found myself in rough alignment with is Bill Maher of all people.
Well, this week I am bringing in another man of the left who has it right. He gets extra points because he is Dutch. He speaks with the directness of a Dutchman, gets the enlightenment, and - more than most - he has stepped in to the field of fire to defend the flag.
The Salamander freedom fighter of the week is Ahmed Aboutaleb, member of the Labour Party, de Partij van de Arbeid (PvdA), and mayor of Rotterdam."
Er, no, CDR. Mr Aboutaleb is no freedom fighter. Counting on him as such would be a grave error. And why?
Oh, you might want to look at what he has overseen in "his" Rotterdam: the conclusion, in 2010, of a building project involving The Netherland's largest mosque:
Here is what Dutch daily De Telegraaf had to say about it on 17 december 2010:
"ROTTERDAM - After more than seven years, on Friday The Netherland's biggest mosque, the essalam mosque on Colosseum Road in Rotterdam, will be opened. The prayer house will be inaugurated by mayor Ahmed Aboutaleb and town selectman Hamit Karakus. Photo: anp
Over the past years the [construction of the] mosque has had its share of troubles. There has reportedly been much influence from abroad, in particular from the UAE's Sheikh Hamdan bin Rashid al-Maktoum. There were also quarrels between the mosque's management and its faithful. This conflict was finally resolved before court. Construction itself was also halted for a long time. In order to complete the mosque, town selectman Hamit Karakus had to step in. He finally got the project back on the rails again, with as end result a completed mosque in Rotterdam-South."
Let us not dwell on the problems during construction, they involved only the refusal to pay some of the builders' invoices and the violation of town regulations concerning the building of large structures. Let us also not dwell on the quarrels between the mosque's management and around 150 of its intended worshippers, quarrels between muslims themselves are sympathetic traits of people of that faith. And let us certainly not dwell on how "Hamit Karakus got the project back on the rails again", as if a threat to withdraw the building permit, coming from a muslim himself, could ever have been considered a danger to the future of this mosque.
No, what we have to focus on here is that it is no coincidence that when you appoint a muslim Mayor of a huge city like Rotterdam, as PvdA Chairman Wouter Bos did in 2008 - a fact we lamented on this very blog - the emergence, sooner or later, of a mega-mosque is practically a given.
Rotterdam's essalam mosque featured in a blogpost of mine on August 10, 2007. As you can see, it was then still in the scaffolds:
But today, in the Year of Our Lord 2015, it is completed, and its minarets and dome part of Rotterdam's skyline:
The purpose of this blogpost is to show that we should not be FOOLED by "enlightened" muslims like Ahmed Aboutaleb. At heart, he is as much a muslim supremacist as his muslim "compatriots" cheering for ISIS. Thing is, Aboutaleb is the man who is content to take a stroll towards the ultimate goal, whereas the triggerhappy blokes boarding planes for Turkey would like to sprint. We can also put it another way: Aboutaleb is MUCH SMARTER. The anger revealed by Aboutaleb in the video above - is it really triggered by the refusal of muslims to come to terms with a quintessentially western concept as freedom of expression?
Or is it anger because the gung-ho dumbasses are obviously confirming in a big and loud way what Geert Wilders & Co have been claiming for years?
My bet would be on the latter. The Charlie Hebdo massacres, the "Young Dutch" wanting to join ISIS - they are thwarting the long-term plans of clever strategists like Ahmed Aboutaleb. To Aboutaleb, twelve dead cartoonists are a nuisance since they constitute a wake-up call for a considerable number of Europeans. Not considerable enough, for sure. A disheartening number of European natives are still dazed and confused and high on the LSD of multiculturalism. But I am sure Mr Aboutaleb can miss Charlie Hebdo repeats like the plague. Because two, three or seven MORE .... and getting building permits thru for mega mosques WILL get more difficult.
NO CDR Salamander, as good as your judgment is in countless matters, I fear that you are seeing the Mayor of Rotterdam, who is no Mayor of Simpleton, in a far too rosy light. Mr Aboutaleb is no freedom fighter. He's a general angry because some dumbass private stepped on a twig, accidentally lit up a flare, or talked too much prior to the Big Offensive. Last week, when a pastor of some small Syrian church community in exile in Rotterdam pleaded with Aboutaleb to "talk with the imams, check what they are saying and rein them in", all the poor man got was a sneer about him not being fully assimilated because of his poor mastery of the Dutch language.
CDR, may I suggest a more apt choice for FbF? Take Filip Dewinter, a leading personality of the Vlaams Belang, in fact, still its most public face.
Only one week ago, Mr Dewinter held a speech in the Belgian Federal Parliament to commemmorate the victims in the Charlie Hebdo massacre, and he opened his discourse by showing perhaps the most famous "motoon" of all - in this instance one personally autographed and handed to him by Kurt Westergaard himself, ten years ago:
Aboutaleb a freedom fighter because he said "rot op"? Nope. It's taqiya, although granted, most of the Dutch muslims may have been too stupid to recognize one of their core concepts at work when dealing with infidels.
But Dewinter holding up THE motoon in a Federal Parliament, right on the heels of the killings? Plainly visible in front of the cameras? On a youtube movie that has the capacity to go viral?? THAT TAKES GUTS.
Alas, I fear Mr Dewinter will not receive freedom accolades very soon. If anything, the showers with liberal doses of faeces that he has endured during his entire 30-year long political career will continue to go on for some time.
But maybe, or rather, without a doubt...
... at some point in the not too distant future...
... when it will have finally dawned on the most ardent bien pensants that they are now living in the dar-al-islam and are now faced with all the niceties on offer in islamic societies, many may remember Mr Dewinter's incessantly delivered dire warnings, and he may finally get the Freedom Figher credit he so richly deserves.
But by then it will be too late.
BREAKING!!! BELGIAN PM CHARLES MICHEL BRIEFS CNN'S...
AHMED ABOUTALEB AND EXTREMIST MUSLIMS: SAME GOAL, ...


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If water is not your thing, why not explore the many top-rated walks in the Mangawhai area, including the famous "Mangawhai cliff walk". The Mangawhai Township with shops and cafes are a pleasant 1 km stroll.
Our Mangawhai Heads Holiday Park is open all year. We look forward to welcoming you to our piece of paradise.
Casual and annual concession sites and off-site caravan storage available.
Mangawhai Heads Holiday Park Map - site locations refer map on right.
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1hr 15 min drive from Dargaville.


"Goodbye," by the City Limits Band, was the most downloaded MP3 from SDReader.com during the month of January. Follows is an interview with songwriter Les Allen.
This is obviously a "love lost" song. I like "the beauty of everything has changed" line. Is that about a specific event or…?
"Hello Insane" captures the post-breakup phase well. Was there a time when you thought you might lose it over someone?
Do you have to be heartbroken at the time to write a heartbreak song, or can you conjure up the feeling later?
Feb. 12, 2009 @ 6:07 a.m.


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Home Articles The Sun Johnsburg Fish & Game hosts Open House
Johnsburg Fish & Game hosts Open House
by Brett Hagadorn
JOHNSBURG The Johnsburg Fish & Game Club held an Open House and Turkey Shoot on Saturday, Sept. 8, at their Oven Mountain Road property.
Founded in 1930 as a sporting club promoting outdoor recreation and the shooting sports, the club gained notoriety in 1958 as the founding organization for the Hudson River White Water Derby. With the intent of promoting the Adirondack region through increased use of the Hudson River, the club retained organization and sponsorship of the event until 1978. The club continues to support their programs through the annual sale of the highly coveted Derby buttons.
In an effort to update their facilities and attract new members, the club recently undertook an initiative to replace its aging shooting bench and shelter with a newly constructed building. As part of the days official events, the new building was dedicated to Town of Johnsburg resi- dents and long-standing members, Roger and Claudette Jones. The couple was honored for dedicated service to the organization spanning over 4 decades.
Im not sure why everybody is making a fuss over me, Jones said. Some of the people who really deserve credit for the new building are Shawn Warrington, Jack Batha and Ben Gadway. They all put a lot of work into it, and we all hope to attract new members because of it.
In addition to its annual dues, and profits received through derby button sales, the not-for-profit organization recently received application acceptance for funding provided through Town of Johnsburg Bed Tax revenue. The funding will be applied toward their ever-increasing operating expenses, with any excess earmarked for future club improvements.
Weve also been working on securing grant money through Senator Littles office, Jones said. Theres federal money being dispersed through the states to support youth sports and outdoor recreation.
With the potential grant funding, the club hopes to implement such enhancements as a covered handgun range, continued clubhouse improvements, and upgrades to their trap and skeet range.
With a roster of 80 members, consisting of residents and nonresidents, the club remains thankful to the select few who remain actively committed to its efforts.
Buck and Evie Goodspeed are responsible for the existence of the club today, Jones said. Theyre the ones who have been keeping it going for the last 20 years.
Beyond his local involvement with the Johnsburg Fish & Game Club, Jones also represents the area by serving on the Warren County Conservation Council and Adirondack Conservation Council. On September 22 he will join other area representatives in the celebration of National Hunting and Shooting Day by participating in an educational event slated for the Dicks Sporting Goods vestibule, located in the Queensbury Aviation Mall.
At this point in my life Im just doing it for the kids, Jones said. To get some interest in shooting and to preserve the Second Amendment.
For further information, contact Buck Goodspeed at 518-251-2762.
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Survivor Profile
During her treatment for breast cancer, biomedical engineer Jessica Winter challenged her laboratory to bring its discoveries to patients more quickly.
by Chris Palmer
AS CHEMOTHERAPY DRUGS coursed through her veins, biomedical engineer Jessica Winter tried to distract herself from her breast cancer treatment by writing grant proposals and reviewing scientific journals, part of her work leading a thriving research lab. But she kept asking herself the same question: "What am I doing with my life?"
Jessica Winter Photo by Jodi Miller
Winter, 40, is a professor of biomedical engineering at the Ohio State University in Columbus. She specializes in creating particles 1/10,000th the width of a human hair, called quantum dots, that light up on imaging scans when they attach to cancer cells in a tissue sample. The dots appear in a variety of colors, making it easier to identify cancer types. Over the past decade, Winter has tweaked the particles to be ever more sensitive to find and attach to specific types of cancer cells. Yet the progress made in her lab left her feeling hollow inside as she was treated with Adriamycin (doxorubicin) and Cytoxan (cyclophosphamide) for her stage III breast cancer.
Then Winter had an epiphany: She would no longer be content to make incremental improvements in cancer detection technology and publish the results in academic journals. She would shift her focus from pure research to figuring out how to turn her lab's discoveries into diagnostic tools that could influence patients' lives more quickly.
"I'm now more interested in creating things that make their way all the way to the patient," she says. It's one thing to publish research papers in journals. "But, in order to actually ever impact anyone, you have to take it to the next step." The next step for her would include leading a new company to bring advanced technology to patients.
"Pretty Science-y"
Winter was born and raised in the Dallas-Fort Worth area. Her father was a physicist for General Dynamics, an aerospace and defense company, and her mother was a chemist for oil and cosmetic companies. In fact, most of her family members are physicians, scientists or engineers. "We're all pretty science-y," Winter says.
When she left home for college at Northwestern University in Evanston, Illinois, in 1993, the 1989 Exxon Valdez oil spill, an environmental catastrophe in Alaska, was still fresh in her mind. She was inspired to study environmental law, but she followed the advice of her uncle, a corporate lawyer, and started out focused on pre-law and chemical engineering. After her first semester, she decided to concentrate on chemical engineering.
Jessica Winter relaxes at home with her daughter, Ali; son, Max; and friend, Aaron Seamon. Ali holds their dog, Cutie. Photo by Jodi Miller
Following college and two years spent making semiconductor chips at Intel, Winter studied chemical and biomedical engineering at the University of Texas in Austin. Her primary project involved using nanoparticles to convert light into electricity and harnessing that energy to stimulate nerve cells in people with nerve damage. She continued this type of research at Ohio State, where she was hired as an assistant professor of chemical and biomolecular engineering after earning her doctorate in 2004. In her new lab, she also began creating quantum dots for labeling different molecular markers of cancer. At first, she created these particles to detect glioma, a type of brain cancer she was studying with powerful imaging equipment. Later, colleagues at Ohio State asked her to create similar quantum dots to identify cancer cells in breast tissue samples.
Three months into the breast cancer project, however, she detected a lump under her arm, and her work on breast cancer took a personal turn. It was 2011 and Winter was 35 years old.
"It was very surprising to me," recalls Winter. "I was in the bathroom, getting ready to take a shower. I noticed when I raised my hand into the air, there was a lump that moved with my arm and it looked odd."
Winter's gynecologist told her it was likely just a cyst, but he advised her to get a mammogram. Three weeks later, Winter went to the Stefanie Spielman Comprehensive Breast Center in Columbus for the procedure. The Spielman Center is part of the Ohio State University Comprehensive Cancer Center. "Everything was in one place," she says. "I had a mammogram in the morning, an ultrasound in the afternoon and two biopsies in the late afternoon."
The diagnosis was stage III hormone receptor-positive, HER2-negative breast cancer. Instead of choosing a lumpectomy and another round of tests—one treatment option for patients in her situation—she opted for a mastectomy. "I said, 'Just cut it off,' " she recalls. "I didn't want to be thinking about it for a long time."
Her decision was vindicated when, during surgery three weeks later, her doctors discovered three breast tumors that were deeply interconnected. "So, I would have had to have a mastectomy no matter what," she says.
Winter made contingency plans for her job right away. She received her diagnosis on a Friday afternoon, and by the following Monday she had informed her department head, chemical and biomolecular engineer Stuart Cooper, that someone would need to take over her teaching load. Winter also gave instructions to her lab manager about keeping the lab running in her absence. The same day, she held an impromptu meeting with the students and technicians in her lab.
"They asked if they could do anything for me and I said, 'Yeah, you can bring me good data to distract me from everything going on,' " she recalls.
Winter took three weeks off work following her mastectomy. A week later she began five months of chemotherapy, followed by three months of radiation. Her first reconstructive surgery was a few months after that. She had four more surgeries, "spaced out however long it took to heal from the time before," she says. The entire experience, from diagnosis to the completion of her surgeries, took 18 months.
The first few rounds of chemotherapy wiped her out. She would work at her lab on Monday, go in for chemotherapy on Tuesday and take the rest of the week off. But even as she recuperated at home, she remained plugged in to the lab. "I like to joke that I ran my lab from a bed with an iPad," she says.
What Are Quantum Dots?
These tiny crystals are increasingly being used to diagnose diseases such as cancer.
Quantum dots are tiny crystals—1/10,000th the width of a human hair—made of semiconductor materials such as silicon. The dots—used in solar cells, lasers, transistors, LEDs for flat-screen TVs, and medical imaging—are increasingly being used in research to diagnose diseases such as cancer. The dots can be attached to biomolecules that, in turn, can latch onto specific proteins on the surface of cancer cells. When poured onto a tissue sample in a dish and viewed under ultraviolet light, the quantum dots light up to indicate the presence of cancer. Pairing biomolecules that attach only to certain types of cancer cells with quantum dots that emit light of a specific color offers a powerful way to diagnose types of cancer and cancer mutations.
Winter's quantum dots, which she calls "multidots," are encapsulated in a special coating and bundled together in a beadlike structure. This packaging improves the nanoparticles' brightness, longevity and stability compared with commercially available technologies. These improvements translate into better disease detection capability, and the multidots' longer shelf life reduces the overall cost of diagnostic tests. Moreover, individual quantum dots within the multidot bundles can be different colors, meaning that multiple cancer markers can be imaged simultaneously, requiring less tissue for testing. Winter is seeking FDA approval for the multidots.
A New Direction
A few months into her treatment, Winter gathered her lab team together once more and told them about her epiphany in the chemo chair and her desire to more quickly turn the lab's discoveries into diagnostic tools that could benefit patients. But changing course was not easy. Funds for turning basic laboratory discoveries into patient tests and treatments, known as translational research, are hard to come by.
Jessica Winter Explains Her Research
In this video, Jessica Winter discusses how her research changed after a breast cancer diagnosis and offers advice for patients with cancer.
"In the middle of my treatment, I remember thinking, 'I'm just not going to be able to do this,' " she recalls. But a group of her graduate students decided to make it happen. They completed patent applications for technologies used to produce quantum dots. Then, with help from Winter's now former husband, financial analyst Adam Winter, they filed paperwork to start a company and made preparations to compete for funding in a small business competition sponsored by Ohio State. While her treatment continued, Winter offered advice to the students but ultimately took a back seat. Her students won the competition, and a few months later, in June 2012, while Winter was still undergoing reconstructive surgeries, they incorporated Core Quantum Technologies, with the mission of developing molecular tools to enhance the detection of cancer.
After her final surgery, Winter was able to take a more active role in the company as its chief science officer. "My students really carried it until that point," she says.
"If you had to describe Dr. Winter in one word, it would be 'unstoppable,' " says Kunal Parikh, one of three members of Winter's lab who co-founded Core Quantum Technologies around the time he earned his undergraduate degree from Ohio State.
"Her experience with cancer probably gave her more perspective in terms of what's the real value she could bring to people with the work she's doing," says Parikh, who began working in Winter's lab as a senior in high school and is now a graduate student at Johns Hopkins University in Baltimore. "I find that kind of perspective to be really powerful."
Core Quantum Technologies plans to conduct a clinical trial with the goal of securing approval from the U.S. Food and Drug Administration to use quantum dots in human tissue samples. The company's technology, however, is not meant to be a first-line diagnostic tool. "That will remain imaging scans," says Winter. The quantum dots "will be something a pathologist would use to define what type of cancer you have [in a tissue sample obtained during a biopsy] and what treatment you need."
A Little Help From Her Friends
During Winter's treatment, her family—including her mother, father, sister and mother-in-law—flew into town on alternating weekends to help out and to watch Winter's then 9-year-old daughter, Ali, and 6-year-old son, Max. "We didn't want the children to see how sick she really was," says Winter's mother, Joan Lutkenhaus. "When she was in bed recuperating, I kept the kitchen going and my husband helped with the kids."
Her family also tried to distract Winter with movies and trips to video game palaces like Dave & Buster's. "Those things worked, but there's always that quiet moment where everything just comes flooding right back in and you can't get rid of it," says Winter.
"Even now, sometimes I will be in a [research] lecture and someone will start talking about cancer and statistics and odds and I will just have to get up and leave," she says. "And it doesn't even have to be breast cancer. It just gets to me. Other times I can be watching gory surgery videos and I'm fine. It's really hard to predict."
For her son, who was very worried while she was in treatment, Winter tried to put as positive a spin on her illness as possible. "I'm sick," she recalls telling him, "but it's like having a broken leg where they have to put a cast on you, and it takes a while, but then you're better." Her daughter, on the other hand, was concerned that she would get breast cancer, too. Winter learned she is negative for the BRCA1 and BRCA2 mutations, but genetic testing—performed as part of a clinical trial she enrolled in—indicated she has a CHEK2 mutation associated with a higher risk of breast cancer. She told her daughter, "Now that I've been diagnosed, you'll start having mammograms at 25, and if you do have anything, they'll be able to catch it before it becomes a problem." Then the scientist-mom in her emerged, and she added, "And that's so far away from now that you don't even know where medical technology is going to be by then, so don't worry about it."
"She was very brave," says Lutkenhaus of her daughter. "She kept a good face on for the sake of her children."
In her lab, Jessica Winter reviews a brain tissue tumor model developed by graduate student Aaron Short, right, and area high school student Rama Balasubramaniam. Photo by Jodi Miller
Her colleagues at Ohio State also pitched in to help. "I'm one of those people that, when I get stressed, I don't eat," Winter says. So for the three weeks leading up to her mastectomy, the university had an informal "Take Jessica to Lunch" program—organized by materials scientist Mary Juhas, then an associate dean in the College of Engineering. Colleagues, some of whom Winter had never met, took her to lunch every day she was at work. "The university [administration] was very, very supportive," says Winter.
Since her last surgery in August 2012, Winter has been on tamoxifen and will continue taking the drug until 2017, when she will switch to aromatase inhibitors to reduce her risk of a breast cancer recurrence. She will also get regular checkups and yearly scans. Winter says she eats healthy and always has. She also exercises every day, mostly yoga, which she had been doing regularly for a decade before her diagnosis, and enjoys hiking and belly dancing. "When I was diagnosed, I started to work out every day rather than twice a week," she says. Between treatments, she eased back into her exercise routine with the approval of her physical therapists. "Every time I was just getting back up to speed, it was time for the next treatment, which was frustrating because I had to start over," she adds.
Her chemotherapy and tamoxifen treatments have left Winter with joint pain, which prevents her from taking part in high-impact activities like running. Simple acts like throwing up her arms after a touchdown at an Ohio State football game can cause her pain.
Jessica Winter stands outside the Chemical and Biomolecular Engineering and Chemistry building at the Ohio State University in Columbus. Her research on quantum dots could advance cancer diagnosis. Photo by Jodi Miller
"One of the things that comforted me very much during all of this was being in nature," she says, mentioning a hiking trail along the Olentangy River near Columbus' Antrim Park. Before she got sick, she used to run the two-foot-wide trail, which is bordered by oak and pawpaw trees. Now she walks it with her Chihuahua. "He'll walk for a bit," she says. "Then he goes in the backpack.
"Being out there among the 100-year-old trees keeps everything in perspective," she says, especially when challenges crop up in her newly refocused research. "At least I now know, though, this is what I want to do, and if I'm not successful, then so be it. But I'm not going to not try."
Chris Palmer is a science writer living in Silver Spring, Maryland.
A Plan of Action
Jamil Rivers supported her husband through two serious illnesses before she was diagnosed with metastatic breast cancer. Her experiences as a Black woman undergoing treatment inspired her to tackle health inequities.
An Unlikely Pivot
Medha Deoras-Sutliff's experience with breast cancer fueled her interest in advocacy for breast cancer patients and, more recently, her support for research on rare cancers.
Staying the Course
A Crash Course in Cancer


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Piancó is een van de 23 microregio's van de Braziliaanse deelstaat Paraíba. Zij ligt in de mesoregio Sertão Paraibano en grenst aan de microregio's Cajazeiras, Itaporanga, Serra do Teixeira, Patos en Sousa. De microregio heeft een oppervlakte van ca. 3.286 km². In 2006 werd het inwoneraantal geschat op 69.538.

Negen gemeenten behoren tot deze microregio:
 Aguiar
 Catingueira
 Coremas
 Emas
 Igaracy
 Nova Olinda
 Olho d'Água
 Piancó
 Santana dos Garrotes

Pianco


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(OR13) BIO-NORMALIZER (NATURAL .JAPANESE FOOD SUPPLEMENTATION) AS A MODULATOR OF OXIDATIVE AND IMMUNE STATUS IN AN ORGANISM
BIO-NORMALIZER (NATURAL .JAPANESE FOOD SUPPLEMENTATION)
AS A MODULATOR OF OXIDATIVE AND IMMUNE STATUS IN AN ORGANISM
J.A.Osato, L.G.Korkina, E.Mikhal'chik, and I.B.Afanas'ev
J.A.Osato,1 L.G.Korkina,2* E.Mikhal'chik,2 and I.B.Afanas'ev2
1 Sun-O Intern., 12 Minami-Machi, Bairin, Gifu 500, Japan
2 Russian Institute of Pediatric Hematology, Leninskii pr. 117, Moscow 117513, Russia
* To whom all correspondence should be directed.
lntroduction
Bio-Normalizer (BN) is a natural health food supplementation prepared by yeast fermentation of Carica papaya and some other tropical herbs and commercially available in Japan and the Philippines. It has been shown that BN exhibited beneficial therapeutic action in a variety of human pathologies and maintained a high quality of life even in very severe suffered patients. BN is also prescribed to enhance an organism's resistance to infections. However, in contrast to already shown practical advantages of BN application as a perspective pharmacological agent, a mechanism(s) of its biological activity is not fully understandable. We [1] and others [2] have shown that BN is a scavenger of active oxygen species. Therefore, BN may suppress free radical overproduction by the direct interaction with harmful oxygen radicals including hydroxyl radicals. At the same time we found [3] that the BN effects on oxygen radical production by phagocytosing cells are much more complicated. Thus, in some experimental models of aseptic inflammation such as peritoneal dextran-, lung asbestos-, cobalt- and bleomycin-induced inflammatory disorders BN significantly suppressed the inflammatory response including hemotaxis and the release of hydroxyl radicals by inflamed monocytes and macrophages but enhanced macrophage recruitment into the inflammatory loci and superoxide production by blood monocytes and tissue macrophages.
These findings suggest that in addition to the direct antioxidant activity of BN, there is probably an even more important regulatory function of BN, which is responsible for its biological activity in various pathologies. In this work we studied the possibility of BN interference with the production of tumor necrosis factor (TNF), which is a potent mediator of cytotoxic activity of macrophages and monocytes [4,5]. On the other hand, the augmentation of phagocyte cytotoxic activity is known to be stimulated by the enhancement of intracellular calcium level [6]. Therefore, it is of utmost interest to consider the effects of BN on the membrane permeability by calcium ions and the production of TNF by phagocytes because the augmentation of both processes by BN will indicate its potential anticancer activity.
BN was produced by Sun-O International Inc., Gifu, Japan, by the fermentation of Carica papaya tropical herbal plants. A major component of BN is a mixture of plant and yeast glycopolysaccharides. In addition, BN contains amino acids (tryptophane, leucine glutamic and aspartic acids, etc.), vitamins B6 and C, glucose, and the protease/antiprotease system of papain. Under our experimental conditions, the suspension of BN granules was prepared daily in Hanks' balanced salt solution (HBSS). In most experiments BN particles were sedimented by centrifugation after the 2 hours incubation in HBSS, and clear supernatant containing soluble BN fraction (SBN) was used in experiments. SBN contained all the above cited compounds excluding insoluble highly mollecular glycopolysaccharides.
Blood drawing and cell isolation. Venous blood (2 ml) was obtained from healthy subjects after their informed consent. Heparinized blood was carefully layered on dextran metrizoate mixture (2 ml, 2:5 v/v) and incubated at room temperature for 30 min. Then, leukocyte-rich top layer was placed on 1 ml Ficoll-Paque (d = 1.119) and centrifuged at 400xg for 30 min. The neutrophil-containing pellet was Washed twice in a cold HBSS and finally resuspended in a minimal essential medium (MEM). Cell suspension contained >95% neutrophils as measured by differential cell count using Coulter counter. Neutrophil viability was equal to 90-98% it was assessed by exclusion of 0.2% typan blue dye.
Animals and macrophages preparation.
Adult male Wistar rats were injected intraperitoneally with 10 ml HBSS and scarified 5 min later. The peritoneal lavage fluid was removed, placed on the top of Monoprep solution (d = 1.068), and centrifuged at 400xg for 30 min. The upper portion containing mononuclear cells was washed twice with a cold Ca,Mg free HBSS and resuspended in MEM supplied with 1% heat-inactivated calf serum. Differential cell count was performed microscopically using Giemsa staining: about 80% cells were macrophages and monocytes the others were lymphocytes, mast cells, and erythrocytes and; > 95% cells excluded trypan blue.
Measurement of intracellular generation of active oxygen species by rat macrophages using fluorescent probe hydroetidine.
Macrophages (3×106 cells) were incubated with 1 mM hydroetidine in 3 ml HBSS at room temperature for 20 min. Then, 10 ng/ml PMA and BN at appropriate concentration was added, and the intensity of fluorescence excited at 473 nm and emitted at 610 nm was measured continuously for 15 min on a Hitachi MPF4 spectrophotometer.
Determination of the rat macrophage permeability by calcium.
The passive permeability of cellular membranes by calcium ions was studied by introduction in the cells of fluorescent calcium indicator Quin 2AM [7]. Rat peritoneal macrophages were incubated with Quin 2AM (2 µM/106 cells) and BN at appropriate concentration in Ca-free HBSS at 37°C for 60 min. Then, the cells were twice rinsed and suspended in HBSS. Calcium efflux was started by the addition of 1 mM Ca ions. After measuring the initial rate of calcium incorporation, the cells were lysed with 0.05% Triton X-100, and the concentration of Quin-bounded Ca was determined. Fluorescence were registered on a MPF-44 a Perkin-Elmer spectrofluorimeter.
Measurement of TNF production by human blood monocytes
Human blood monocytes (2.5×106cells/ml) were isolated using the modified Beutler method on a Ficol-Paque gradient (d= 1.077) and incubated with the soluble part of DN at appropriate concentration in the RPMI 1640 medium at 37°C for 1 hour. Then, the cells were centrifuged, washed and incubated in the same medium supplied with 1. 0% fetal calf serum in the 24-vial planshet for 14 hours. The content of TNF in supernatant was determined using TNF-sensitive murine fibroblast cell line L929. The fibroblasts were placed in the 96 vial planshet, and the supernatant was added to an each vial. The content of nonlysed fibroblasts was measured by light scattering method by staining of the viable cells with crystal violet dye. The TNF concentration in the supernatant was calculated by using the calibration curve obtained with recombinant TNF-α in the concentration range of 16-1000 pg/ml.
Present findings suggest that BN affects different pathways of monocyte and macrophage activation stimulating the release of active oxygen species and TNF. Indeed, the incubation of rat peritoneal macrophages with BN resulted in an approximately 115% increase in the intracellular production of active oxygen species measured by hydroethidine fluorescence (Fig.1).
This fact supports our previous findings [1] showed that BN sharply increased macrophage lucigenin-amplified chemiluminescence, which is a specific test of superoxide formation. It may indicate that BN is able to interfere with the activation of phagocyte NADPH oxidase, a major oxygen radical-producing enzyme of phagocytes. This suggestion seems to be supported by the present study of macrophage permeability by calcium. It is seen (Fig.2) that BN increased calcium efflux into blood neutrophils and rat peritoneal macrophages in a concentration- dependent manner by 1.45-1.6 times. It is well-known that there is a Ca-dependent pathway of NADPH oxidase activation, which probably depends on protein kinase C [8] Therefore, an increase in calcium efflux by BN appears to be one of main cause of the enhancement of intracellular oxygen radical generation.
Another important effect of BN on phagocyte activity is the stimulation of TNF production by blood monocytes (Fig.3). It is seen that BN increased TNF production by monocytes in a concentration-dependent manner with a maximal TNF level at 1 µg/ml BN. Thus, we can now recognize at least two major mechanisms of BN supposed cytotoxic activity on tumor cells. First one is the stimulation of oxygen radical release by phagocytes
1. J.A.Osato, L.G.Korkina, L.A.Santiago, and I.B.Afanas'ev, Effects of Bio-normalizer (a food supplementation) on free radical production by human blood neutrophils, erythrocytes and rat peritoneal macrophages. (1995) Nutrition: Intern.J.Appl.Basic Nutr.Sci. 000-000.
2. L.A.Santingo, J.A.Osato, M.Hiramatsu, R.Edamatsu, and A. Mori, Free radical scavenging action of Bio-catalizer α·ρ no.11 (Bio-normalizer) and its by-product.(1991) Free Rad. Biol.Med. 11, 379-383.
3. J.A.Osato, I.B. Afanas'ev, Z.P.Cheremisina, T.B.Suslova, N.E.Abramova, E.V.Mikhalchik, I.B.Deeva, L.A.Santiago, and L.G.Korkina, Bio-normalizer as a modulator of phagocytosis and free radical production by murine inflamed neutrophils and macrophages. (1995) Phys Chem. Biol. Med. 2, 000-000.
4. P.J.Edelson, Monocytes and macrophages: aspects of their cell biology, in: Cell Biology Inflammation, Elsevier, Amsterdam, 470-495 (1980).
5. L. Gagnon, L.G.Filion, C.Dubois, and M.Rola-Pleszczynski, Leukotrienes and macrophage activation: Augmented cytotoxic activity enhance d interleukin 1, tumor necrosis factor and hydrogen peroxide production. (1989) Agents Actions 26, 141-147.
6. J. W.Putney, Stimulus-permeability coupling: role of calcium in the receptor regulation of membrane permeability. (1979) Pharm.Rev. 30, 209-245.
7. J.S. Johansson and D. Haynes, Delibirate quin 2 overload as a method for in situ characterization of active calcium extrusion systems and cytoplasmic calcium binding: application of the human platelets. (1988)J.Memb.Biol. 104, 107-163.
8. T.Malsumoto, K.Takeshige, and S.Minakami, Spontaneous induction of superoxide release and degranulation of neutrophils in isotopic potassium medium: the role of intracellular calcium. (1986) J.Biochem. 99, 1591-1595.


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