The strangest thing I found over the next few days was listening to my body. I have always been the person who, if I have a cold or any illness I ignore it and keep going until it goes away. This was different, this was something I couldn't control. I was getting up and walking up and down the corridor as much as I could, I heard my body telling me to sit down, I felt my muscles giving up and getting tired. In my mind, I'd say just a few more steps, but before I could attempt it I was sitting back in bed. This was my first lesson, listen to my body because right now it knows better than my mind does.
Every day I got stronger and felt a tiny bit like myself again, I was stiff and sore and tired a lot but I was in a better position than I was 4 days before. When my dressings came off it was the first time I had seen my scar. This was something that didn't bother me, for many people it will bother them and it can be scary to see it at first. I was excited to see it. You might assume that being into beauty, being a young woman this would be my biggest problem but it wasn't. When the nurse removed the bandages my first thought was, 'oh there it is, not so bad', then I took a picture of it!!! Now another thing to understand about me is that I'm not a soppy type of person. I don't get upset or cry for nothing……. And either does my mam. When she first saw my scar, she told me I look like Frankenstein, sensitive I know but it made us laugh.
I was told before my operation that I would be in hospital for about 6-8 days, so I averaged it about seven days! On the Saturday morning, my consultant came to see me. We chatted about everything, he checked out the wound and told me I would be going home the next day. 5 days after my operation I was being let home. I was excited, I was scared too, but anxious to get out. This won't happen to everyone, I had made good progress in hospital, I had youth and fitness on my side, I was lucky. I told mam and Martin and they were delighted. Saturday went by in my usual routine of walking the corridors, taking naps, watching tv and reading. Then came Sunday. I was awake every morning at 6am when the nurses came in to do their usual blood pressure and weight check. I sat waiting for the surgical registrar to come in and discharge me. Mam came in and had my room packed up in about 5minutes flat, pretty sure that was record time! The registrar came in and I was waiting for a list of instructions of do's and don'ts but he was ready to walk out the door until I asked what I should and shouldn't do. Reluctantly it seemed he gave me the bare minimum. No lifting anything, no excessive walking, lots of rest, no swimming and we'll see you in 4 weeks. That was it I was on my own to figure this out.
Mam brought me down to the car in a wheelchair……I'm fairly sure this isn't the way things should work, but we had no other option!! We got into the car and left the safety of the hospital. Leaving the carparks there were ramps……ramps plus car, plus human just after open heart surgery didn't go very well!!!! Even going over bumps in the road on the way home hurt, another lesson for me to learn. Up until this point I had kept my spirits up. As we were driving home past the hospital they faltered. I was looking at the hospital and I was scared, what was going to happen, how hard was this going to be, once again it was the unknown that got to me. I knew I'd have to work it out I just wasn't sure how. I got home and the first thing I did…… after getting back into my pyjamas of course! Was to go for a little walk. Yes, I walked up and down my estate in my pyjamas, if this was all I had to worry about I was dong ok. That evening I went to bed for a while. I got back up, watched TV, then went back to bed expecting to sleep my brains out in my own bed. No such luck. I went to bed at 8pm, nothing I did made me comfortable, I couldn't sleep and my brain felt like it was in overdrive. Eventually at about 12am I must have drifted off. If I got 5 hours sleep that night I was lucky.
I was home and this was the start, the start of the only part of this journey that bothered me. How do I recover and what will happen to my body as I do? I had to remember my first lesson, listen to my body and let it take over. The photo I've put in is me, it's my scar and its now part of my story. Like a tattoo I have on my wrist it's there forever. A conversation starter in future maybe, who knows, but its mine and it's a reminder of what I can do, where I've been and the start of something new.


George Bell & Sons, 1877, Hardback ..
Condition: Very Good. Cover slightly rubbed at extremities with a few marks. Mildly bumped at head & tail of spine and corners. End papers spotted. Inscription on ½ title page. Some top edges turned otherwise a very well presented copy.
Dark blue cloth with gilt titling on spine, embossed border on front cover. Portraiture frontispiece. 29th Thousand.


text:
"Maybe Tonight" is a 2006 song by Kate DeAraugo.

Maybe Tonight may also refer to:

Music

Albums
Maybe Tonight, EP by Maggie Rose, or its title track
Maybe Tonight, album by Cathal Hayden 2002
Maybe Tonight, album by Joyside
Maybe Tonight, album by Four Men and a Dog
Maybe Tonight, EP by The Jolt, 1979

Songs
"Maybe Tonight" (Laura Branigan song), 1985
"Maybe Tonight" (Sandra song), 2012
"Maybe Tonight", song by Emmylou Harris from Last Date, 1983
"Maybe Tonight", English language song by Greek band Onirama
"Maybe Tonight", song by the Knack, from Get the Knack, 1979
"Maybe Tonight", song by The Summer Set from Legendary
"Maybe Tonight", song by William Tell, from You Can Hold Me Down
"Maybe Tonight", song by Murray McLauchlan
"Maybe Tonight", song by Lovelock on DJ-Kicks: Chromeo
"Maybe Tonight", song by Shawn Fogel on album Millions Of Miles Away
"Maybe Tonight", song by Magnum, from The Gathering, 1988
"Maybe Tonight", song and single by The Shirelles, 1964
"Maybe Tonight", song and single by Vince Gil from When Love Finds You, 1995
"Maybe Tonight", song by Earl Klugh from Sudden Burst of Energy, 1996
"Lovin' Tonight (Maybe Tonight)", song by The Arbors, 1969
"Maybe Tonight", song by Catch
"Maybe Tonight", song by Sandee from Only Time Will Tell
"Maybe Tonight", song by Brooke Allison, from Brooke Allison
"Maybe Tonight", song by Nicole Atkins, from Neptune City

redpajama_set_name: RedPajamaWikipedia


text:
Register for Jan 19th Event
CaringALS
ALS Speech Study
Search Engine Interaction
Understanding the brain is among the science's great frontier and key to developing cures for ALS which would open doors for many other untreated neurological diseases.
We have known about ALS for over 100 years now and yet there are no treatments! The pace of innovation is accelerating. We're seeing advances in so many areas at the same time - Genomics, artificial intelligence, machine learning, wearables as biomarkers etc. Technology is key to enabling innovation in rare diseases. We are confident that with today's innovations in healthcare, data analytics, genome therapy and many more, we will find a cure.
EVERY 90 MINUTES
Every 90 minutes someone is diagnosed with ALS
2-5 YEAR LIFESPAN
'NO' treatments are found for ALS and 2-5 years to live
5 IN 100,000
Approximately 5 of every 100,000 deaths are caused due to ALS
NO FAMILY HISTORY
90% of people diagnosed with ALS have no family history
ALS affects as many as 30,000 in the US, with 5,000 new cases each year
5X HIGHER
ALS is 5x higher than Huntington's disease; equal to multiple sclerosis
We can only make progress with the support of those who share our goal.
With your support, EverythingALS a part of Peter Cohen Foundation, 501(c)3, will grow programs that will result in a cure for ALS and make history together!
Our supporters include families, friends and also whose lives have been touched by devastating brain disorders and individuals who find the enduring mysteries of the brain worthy of curiosity-driven science. The Peter Cohen Foundation values all philanthropic investments, big or small; together, all gifts catalyze novel research and treatments for ALS.
A sampling of our supporters are listed below
1568 Plateau Ave, Los Altos, CA 94024
Email: info@everythingals.org
© 2021 by EverythingALS

redpajama_set_name: RedPajamaCommonCrawl


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text:
9/1/20 Protecting COVID Research at American Universities from Foreign Hackers
9/1/20 ICYMI: Lucas and Barr Op Ed in The Hill: Protecting COVID Research at American Universities from Foreign Hackers
7/28/20 Investigations & Oversight Subcommittee and Research & Technology Subcommittee Hearing - The Role of Technology in Countering Trafficking in Persons
6/24/20 Lawmakers introduce bipartisan legislation to support U.S. research community during pandemic
6/19/20 Investigations and Oversight Subcommittee Hearing - Repurposing Therapeutic Drugs for COVID-19: Research Challenges and Opportunities
6/15/20 Chairwoman Johnson and Ranking Member Lucas Introduce Surface Transportation Research & Development Act
5/14/20 Top Committee Republicans Oppose "Partisan Assault" of House Minority Rights
5/4/20 Top House Republicans Announce Probe Into Chinese Efforts to Infiltrate U.S. Colleges
4/24/20 House Science Committee Leaders Criticize FCC Action on Orbital Space Debris
4/23/20 H.R. 6599, the Computing Opportunities to Vanquish Infectious Diseases (COVID) Research Act of 2020


text:
Q: How to take first and second part of custom symbol in the words I would like to separate a words in oracle column which is having 'MAT CHAMPAIGN - SOUTH---->MAT EP - KK'
i tried the below code to get
select regexp_substr('MAT CHAMPAIGN - SOUTH---->MAT EP - KK','([^,--->]+)',1,1) from dual : output is MAT CHAMPAIGN
select regexp_substr('MAT CHAMPAIGN - SOUTH---->MAT EP - KK','([^,--->]+)',1,2) from dual : output is SOUTH
actually i am trying to get  MAT CHAMPAIGN - SOUTH in one col and MAT EP - KK as a second column based on the symbol --->
Kindly help

A: You may try using REGEXP_SUBSTR with a capture group:
SELECT
    REGEXP_SUBSTR(col, '(.*)---->', 1, 1, NULL, 1) AS first,
    REGEXP_SUBSTR(col, '---->(.*)', 1, 1, NULL, 1) AS second
FROM yourTable;

Here we are using a regular expression to match and capture everything either before or after the ----> separator.

A: select
  regexp_substr('MAT CHAMPAIGN - SOUTH---->MAT EP - KK','^(.+?)---->',1,1, '', 1)col1
, regexp_substr('MAT CHAMPAIGN - SOUTH---->MAT EP - KK','---->(.+?)$',1,1, '', 1)col2
from dual ;

redpajama_set_name: RedPajamaStackExchange


Resilience Agenda believes there are cognitive, behavioral and lifestyle steps people can take to improve their Mental Health, and that preventative and wellness inspired action can be taken prior to the intervention of professionals, and before people reach crisis point.
Resilience Agenda believes that self-care, well-being, self-development and self-discovery is not selfish or a luxury, but instead a way to 'sharpen the saw' to makes life more meaningful, enjoyable and effective.
Resilience Agenda's metaphor of Mental Fitness implies that desired change and goal-oriented progress is possible, and that like physical fitness, maintaining good mental health is an ongoing pursuit. People can be positive, proactive and preventative and build their Mental Fitness with the right mindset and strategies.
Resilience Agenda believes that the Mental Health Awareness message will be more effectively promoted through action-oriented language, with language that aims to achieve positive goals rather than avoiding negative goals, as well as language that focuses on the transitory nature of mental ill-health benefits and symptoms.
Resilience Agenda believes that businesses and brands have a role in improving the collective Mental Health of society. We believe that sanctifying Mental Health as 'special', 'different' or outside the realm of commerce only entrenches stigma, rather than reduces it.
Physical items in our environment prompt or nudge us to think in certain ways and help shape our thoughts and actions.
Resilience Agenda produces lifestyle and gift items that are used over an ongoing period of time, so that these environmental effects can become inbuilt habits.
Carrying or using a Resilience Agenda product or engaging with our online material signifies the importance someone places on the value of Mental Health in their lives.
Owning, giving and using Resilience Agenda products gives people the opportunity to explain and share the Mental Health Awareness and Normalization message in new and engaging ways.
Resilience Agenda's lifestyle and gift products, and ongoing engagement with the Resilience Agenda brand, can effectively communicate helpful lifestyle strategies so that people can build their Mental Fitness.
Currently, options are very limited for consumers wishing to 'purchase' the gift or lifestyle benefits of Mental Well-being, Mental Fitness or Self-Development in an affordable non-service sector way.
Resilience Agenda is a brand built on a fundamental WHY – Changing the way people engage with the topic of Mental Health so that they become more positive, proactive and preventative in their approach.
Our goal is that people looking for self-development and Mental Fitness strategies, products and giftware turn to and trust Resilience Agenda because of its values, approach and vision.


Modern scientific illustration with complex digital data.
The first digital circuit of neurons, astrocytes and blood vessels made at Blue Brain Project. This illustration is the result of an on-going long term collaboration with scientist E. Zisis. What you see here is the tip of the iceberg as a lot of my visualisation and technical research went into debugging the model with images until I could design the final illustration, a usual workflow in digital illustration for science.
In the brain, neurons are supported and regulated by other types of cells known as the glia. Among the glia, astrocytes are territorial cells – shown here in blue – that, among other complex interactions with their surroundings, take nutrients from the blood vessels in red and distribute them to neurons in yellow. But astrocytes do more than that. For instance, they support a part of the synaptic activity within their domain. What you see in this illustration of neocortical grey matter is roughly 1.5mm tall and 0.5mm wide.
Shaker (Python lib I developed), Blender, Cycles raytracer modification.
Le grand Atlas du cerveau (2018). Glénat Livres.
Illustration showing connectivity patterns – such as the "rich club" in the middle – found in simulations of neuronal activity within what appears to be a chaotic forest.
This artwork illustrates data obtained with electron microscopes of a small brain tissue.
A variety of cells are visible here, from microglia in blue/turquoise to neurons in purple, astrocytes in orange-yellow with a perivascular process and also myelinated axons in dark blue and blood vessels, here not reconstructed as endothelial cells, which shows the limits of the reconstruction.
The 3D models except red blood cells were automatically reconstructed from EM stacks by scientist Corrado Cali.
Scientific illustration selected by Cell journal to make the cover for a major BBP publication about the microcircuitry of the brain. I also contributed other figures to this publication.
Aesthetic Merit, Seeing Life Science, EPFL 2018.
Using field-based meshing – aka "metaballs" in Blender, I developed a way to automatically reconstruct 3D surfaces for large datasets. This method builds the mesh by blocks so it can build any dataset.
The graph skeleton was calculated by E. Zisis and the raw data was provided by Bruno Weber et al. ETHZ.
On top of automatically creating the 3D models for this illustration, I proposed a way to illustrate perivascular end feet – the parts that wrap around red tubes – with particle simulations that extend and flow over the capillaries.
This shows how astrocytes interact structurally with blood vessels. The figure below illustrates in more details what happens at a molecular level.
Illustration about noradrenergic modulation of energy supply in the neuro-glial-vascular ensemble or in less barbarious terms, how molecules flow and interact between blood vessels, astrocytes and neurons.
A major step after reconstructing vasculature is to have synthesized astrocytes filling a good part of the volume occupied by blood vessels and neurons. Here neurons are not shown. The astrocytes in blue grow special branches in white that are about to wrap nearby capillaries in red to get nutrients and distribute them to neurons, among many other roles theses cells perform.
This is the first illustration that could benefit from a mesh-less concept based on Cycles raytracer, enabling large-scale visualisation in Blender.
This inspired BBP visualisation team to explore similar techniques for large-scale visualization.
A close-up view of the 4138 local connections – input spines and output boutons – that this neuron forms with other cells (invisible here) in a neocortical circuit. Given points on the surface of the branches and end points, I developed a way to represent spines in a realistic way, based on scientific papers documenting neuron spine types and sizes.
Shaker (meshing algo), Blender, Cycles.
Illustration of algebraic topology applied to neuronal simulations. This is an artistic interpretation.
and the EPFL event page.
Illustration concept of algebraic topology coupled with neuronal simulation. Using simulation data on the left hand, I revealed the other "multidimensional side" in an orthogonal projection. Black and white here is a visual code I chose for domains that are beyond our sight. When many neurons are connected together at a given time, they form simplices of high dimensional orders and even "cavities", such as the one illustrated here.
This publication generated a small buzz in the scientific community with over 90'000 views in two weeks and a lot of questions asked to BBP.
Nano particles of gold are positioned to make a nano gap of about 7Å. When this gap is lit with a precise wavelength, tiophenol molecules react, "store" photons and scatter them soon after [Raman scattering]. Philippe Roelli et al. described the inner workings of this phenomenon which resulted in a lot of attention in the scientific community. This paves the way for new technology.
Tobias Kippenberg, Philippe Roelli et al.
Volumetric data of all sub-regions within the rat hippocampus, with a Nissl staining from an image stack that was the basis for calculating these volumes.
A digital circuit of the hippocampus CA1, a collaboration with engineer Cyrille Favreau using the open-source visualiser "Brayns".
Blue Brain Project's contribution to HBP, a separate entity.
Distribution of neurons cores in thalami (yellow-orange regions) and hippocampi (blue regions) in the rat brain.
Complex datasets are often filtered by sampling/reducing the amount of visible elements. Here I tried to reveal all brain regions at once, with a work on transparency.
Using 3D surface reconstructions of all regions of the mouse brain, this was an attempt to reveal this intricate organ that measures a mere 1.3cm in length.
A frontal view of a thousand neurons in a circuit. They are coloured according to their position within the six layers of the neocortex with an approximate height of 2.2 millimetres.
Synapses evolve over time. While connections are formed and strengthened, others dissolve.
This illustration was requested to show research on neuroplasticity which got a grant of 100M core hours offered by ALCF (Argonne, USA) to Blue Brain in order to run simulations to study plasticity in the neocortex.
This is one of the largest simulations of the neocortex that BBP produced in mid 2017. The simulation is 87 Terrabyte large for a mere 217'000 neurons. A collaboration with engineer Cyrille Favreau.
Illustration of neocortical densities of neurons (red), astrocytes (green) and blood vessels (blue). Intricate details appear close-up. The denser layer 4 is clearly visible in this illustration.
A vast majority of the artworks here were created with Blender & Cycles. Automatic 3D reconstruction of neurons, glia and blood vessels were carried out with Python & Shaker, a peer-reviewed Blender plug-in I developed at that Blue Brain Project. Of course not everything is automated. I make the tools do the necessary work of consuming data and then the artistic and design parts take over.
"What are these artworks for?"
These artworks are produced for scientific publications and public communication alike. They are the results of collaborations with scientists and sometimes engineers. Making an illustration very often helps in improving the digital model by visual debugging. All illustrations here are made with real data consumed with code.


text:
The volunteer board is the strategic heart of PRSA NCC and it ensures that in our work for communications and public relations professionals, the chapter delivers impactful industry events, responds to changes in our community, fosters diversity and inclusion, and always upholds the highest ethical standards.
Members of the board of directors help establish the chapter's strategic direction, oversee chapter programming, participate in the development of the annual budget, cultivate the next generation of communications and public relations professionals, and more.
For detailed information about the duties of officers and directors, the election process, and more, please review the PRSA NCC Chapter Bylaws.
President: The President shall be the titular head and official spokesperson of the Chapter; shall preside at all meetings of the Chapter, Board of Directors, and Executive Committee; and, in general, shall supervise the affairs of the organization. Subject to the advice of the Executive Committee and approval of the Board, the President shall appoint all Committees and serve as ex-officio member of each, except as otherwise provided in these bylaws, and with advice of the Executive Committee, shall determine the dates, hours, and places of meetings of the Chapter and Board. The President shall also be the public representative of the Chapter and is authorized to delegate this responsibility. The President shall be insured by a position bond in an amount determined by the Board of Directors. The President shall serve as a PRSA Leadership Assembly delegate, and if he/she cannot attend, will provide proxy authority to an elected delegate.
President-Elect: The President-Elect shall perform all duties in the case of the President's inability to serve or upon the President's direction. In the event that the office of President becomes vacant during the term of the incumbent, the President-Elect shall succeed to the Presidency for the remainder of the term and shall retain the Presidency during the year for which he or she was elected. In the absence of the President from any meeting of the Chapter, Board, or Executive Committee, the President-Elect shall perform such duties as may be assigned by the Board of Directors or by the President, including supervision of a portfolio of committees. The President-Elect automatically succeeds the President on January 1, upon expiration of the President's term of office. The President-Elect shall serve as a PRSA Leadership Assembly delegate, and if he/she cannot attend, will provide proxy authority to an elected delegate.
Vice-President(s): The Vice Presidents shall perform such duties as may be assigned by the Board of Directors or by the President, including supervision of a portfolio of committees.
Secretary: The Secretary shall keep a record of all actions of the Chapter, Board of Directors, and Executive Committee and shall issue such notices as shall be formally required for regular and special meetings of the Board. The Secretary shall supervise conduct of the Chapter's electoral process in selecting new officers to ensure that it complies with these bylaws. The Secretary shall act as Chapter historian in maintaining and properly preserving minutes, committee reports, and officers' reports. The Secretary shall supervise the Bylaws and Elections Committees and any other committees designated by the President.
Treasurer: The Treasurer shall be custodian of the Chapter's funds, having responsibility for the accounting of all monies collected and disbursed. He or she shall maintain deposits in banks or other depositories as may be designated by the Board of Directors; be a signatory of checks, drafts, and other instruments pertaining to the acceptance, deposit, withdrawal, and disbursement of such funds; and report to the Board monthly income and expenses through the end of the preceding month. At all times, he or she shall have all funds, records, and vouchers available for inspection or verification by the Financial Review Committee.
He or she shall render an annual statement at the expiration of his or her term of office, and deliver to his or her successor all monies, books, and other property or, in the absence of the Treasurer Elect, to the President. The Treasurer, with the approval of the President, is authorized to appoint an Assistant Treasurer to serve a concurrent term. The Treasurer and appointed Assistant Treasurer shall be insured by a position bond in an amount determined by the Board of Directors. At such times as persons or firms provide management services under contract approved by the Board of Directors, the Treasurer shall be accountable for ensuring the timely and responsible performance of any or all financial tasks performed by the contractor.
Director(s): Members of the Board of Directors shall establish policy, adopt an annual budget, approve contracts and expenditures for all necessary items and services in connection with the management of the Chapter, authorize the creation of standing committees by the President, provide for the business and conduct of annual and other meetings of the Chapter and of the Board of Directors, authorize Chapter sponsorship of conferences and workshops, perform such other duties as are prescribed elsewhere in these bylaws, and delegate its authority, powers and duties to officers and committees as it so decides. Individual Board members may be designated by the President to oversee committees.
2021 PRSA NCC Board of Directors Nomination Form
The 2021 PRSA NCC Board of Directors Nominations have closed....
Our chapter is governed by a 17-member board of directors,...


Table Quiz at Roganstown Hotel is the main school fundraising event, taking place on Friday 22nd March. Kick off the Easter holidays with a great fun night out with the opportunity to win €400 prize money, a Tombola or spot prize. There's a raffle and an auction to ensure nobody goes home empty handed. Great prizes, great craic & all in aid of maintaining the facilities and activities our children enjoy and benefit from in our school. Watch this space over the coming weeks for details of the raffle & auction prizes on offer.
Auction Items include Robbie Williams tickets, All-Ireland Final tickets, Late Late Show tickets and many more!


text:
A Moving Tribute…one Tweet at a Time
Amy Derjue
SM& Team
By Michal Regunberg, SM& Senior Vice President The Boston Globe's David Filipov, whose father Al was on the first plane to hit the World Trade Center on 9/11, wrote a moving and riveting story about that day and the 12 years since in a way that I have never seen before: through a series of 22 Tweets. (@davidfilipov). Like a gripping novel where you are turning each page to keep up with the action, these Tweets had the same effect: you waited for the next…and the next. In this case, you really had no way of knowing how many tweets there would be, and it was very possible to miss some of them. But it didn't matter because each one of the Tweets, with its 140 characters, told its own story. It's not unlike when you start a good book but don't end up finishing it: you get a snapshot or you get the whole story. His Tweets had the same effect. There's a liberating feeling about what Filipov did. So often the 140 characters seem to restrict how much you feel you can say. Instead, Filipov demonstrated there's a way to use the technology to expand (not contract) the message, and to tell the story he really wanted to tell.


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The new service, named Lightspeed G, provides Internet speeds of up to 1,000 megabits per second (mbps) – or one gigabit – to Jamestown, Russell Springs, Columbia and Russell County's two business parks. Lightspeed G is available in those areas immediately and it will be offered to businesses and residents in other areas of Russell County as the network is expanded.
Lightspeed G will provide download speeds of 1 Gbps, which is more than 100 times faster than Duo County's current standard Internet service. While the obvious benefits of this speed include extremely fast movie downloads and rich online games, Russell County businesses that need to access cloud resources and download and transmit large data files will experience immediate results.
In 2010 Duo County Telecom announced it would begin building a fiber-optic network that would deliver lightspeed data signals to homes and businesses. Lightspeed G is made possible by a state-of-the-art network that contains three things: 1) all-fiber delivery, 2) cutting-edge network equipment, and 3) a solid path to the Internet backbone that can carry exponentially larger amounts of data than most services in the United States carry today.


Hi, I am writing from NYC. I plan to be home in Hiratsuka area for about a 1 week at the end of the month, and looking for route for training. I am a Cat-3 amaetur racer in the US, and want to keet training while I am in Japan.
I am looking for relatively traffic free, and hilly roads to ride starting from the City of Hiratsuka. I am hoping to log in about 60-100 miles in one ride.
If anyone has any clue, please let me know. I plan to start pretty early in the morning everyday from 8/27-8/31, so if anyone in the area would like to join, GREAT! Thank you so much.
Let us know when you are in Japan. Maybe I will be free.


text:
NeuroAid II (MLC901) and polypharmacy in stroke and the risk of hepatotoxicity: a case report
Anna Misya'il Abdul Rashid ORCID: orcid.org/0000-0003-2042-71431,2,
Mohamad Syafeeq Faeez Md Noh4,
Abdul Hanif Khan Yusof Khan1,
Wei Chao Loh1,
Janudin Baharin1,
Azliza Ibrahim1,
Liyana Najwa Inche Mat1,
Wan Aliaa Wan Sulaiman1,
Fan Kee Hoo1,
Fazah Akhtar Hanapiah3 &
Hamidon Basri1
NeuroAid II (MLC901) is a promising therapy for stroke patients who present outside of therapeutic window for reperfusion therapy. Studies have proven its efficacy in ischemic stroke; however, data of drug safety and combination with other medications especially anticoagulants are heterogenous. We report a possible case of hepatotoxicity induced by NeuroAid II in combination with anticoagulants.
We report an elderly patient who developed symptoms of cardioembolic stroke presented outside of time window for reperfusion therapy. He was started on a regiment of statins, anticoagulation, beta blockers and NeuroAid II. One month later he presented with deranged liver enzymes. Cessation of NeuroAid II resulted in rapid improvement of transaminitis within days.
We wish to highlight the potential harmful effect of administering NeuroAid II with an anticoagulant and the importance of routine follow-up and blood monitoring in the elderly patients with stroke.
Neurological disorders cause significant disability and death worldwide, exceeding cardiovascular diseases and malignancies. Among the neurological disorders, stroke contributed the largest proportion of total disability-adjusted life years (47.3%) and mortality (67.3%) [1]. Despite this, therapeutic options are sparse, with thrombolysis limited to a four and a half hours' time window and thrombectomy to the first 24 h after stroke onset. If a patient presents later, the only modality of treatment is rehabilitation and physical therapy, admission to stroke unit as well as decompression craniectomy for malignant middle cerebral artery (MCA) infarcts.
A recent interest has been budding in the field of post-stroke neuroplasticity, where a specific gene, namely, the brain derived neurotrophic factor (BDNF), is responsible for neurogenesis, neuronal differentiation and survival in response to cerebral ischemia [2]. A novel drug, MLC 601 (NeuroAiD) and MLC 901 (NeuroAid II), which is a Traditional Chinese Medication (TCM) consisting of nine herbs (Radix astragali, Radix salviae miltiorrhizae, Radix paeoniae rubra, Rhizoma chuanxiong, Radix angelicae sinensis, Carthamus tinctorius, Prunus persica, Radix polygalae and Rhizoma acori tatarinowii) and five animal components (including Hirudo, Eupolyphaga seu steleophaga, Calculus bovisartifactus, Buthus martensii and Cornu saigae tataricae) has demonstrated neuroprotective and neuroregenerative effects in brain ischemia [3, 4].
Although many efficacy trials relay its safety, reporting very mild side effects, such as dry mouth and gastrointestinal side effects; that resolves after dose reduction [5], data on polypharmacy and combinations with anticoagulants are sparse [6,7,8]. We would like to share our experience with a case of possible NeuroAid II induced hepatotoxicity when combined with anticoagulants and possible detrimental side effects of polypharmacy.
A 73-year-old man with underlying dyslipidemia and hypertension was found unconscious at home. He is a retired engineer, and is living independently on his own. He was not compliant to his antihypertensives and cholesterol medications as he was asymptomatic. He also denied any previous history of liver disease or any drug induced complications prior to this. It was unclear for how long he had been unconscious or unwell as he was not able to recall the chronology of events. Upon assessment, blood pressure was 120/80 mmHg with pulse rate of 100 beats per minute. He was noted to have right sided hemiplegia with increased tone and reflexes, dysphagia and dysarthria. His total National Institute of Health Stroke Scale (NIHSS) was ten. Electrocardiogram (ECG) showed atrial fibrillation (AF) and echocardiogram showed good ejection fraction of 76%, moderate left ventricular hypertrophy with normal cardiac chambers and valves. There were multiple grade two and three pressure ulcers on his right temporal region, right anterior chest and right hip, which were not previously present. An urgent magnetic resonance imaging (MRI) of the brain revealed bilateral acute and established pontine infarcts, left more than right with microvascular ischemia in the deep white matter of the brain (Fig. 1). Magnetic resonance angiography (MRA) of the brain showed narrowing of the left posterior cerebral artery, but no evidence of large vessel obstruction (Fig. 2). As he presented late, he was not a candidate for thrombolysis or thrombectomy. Hence, he was admitted for conservative management, rehabilitation and wound care.
Axial sections at the level of the brainstem, on the diffusion weighted imaging (DWI) (top row) and apparent diffusion coefficient (ADC) sequences (bottom row) show patchy areas of restricted diffusion
Magnetic resonance angiography (MRA) shows no evidence of large vessel occlusion
Initially he was started on aspirin, which was changed to apixaban five mg twice daily after 14 days of stroke onset. He was also started on atorvastatin 40 mg at night, NeuroAid II two capsules three time daily, beta blockers and proton pump inhibitors. His baseline blood investigations were as follows: hemoglobin 14 g/dL, platelets 180 × 109/L, white cell count (WCC) 8.5 × 109/L, total serum bilirubin (TSB) 10 μmol/L, alanine aminotransferase (ALT) 62 IU/L, aspartate transaminase (AST) 75 IU/L, Albumin 27 g/L. C-reactive protein (CRP) was elevated 134 mg/L. Renal profile showed acute kidney injury (AKI) with urea 10 mmol/L and creatinine of 123 μmol/L.
His pressure ulcers required multiple courses of antibiotics, daily dressings and debridement. It was particularly challenging as it involved a large area and healing was hindered by his thin, aging skin. We postulated that he has been neglected for several days, prior to presentation to cause such an extensive pressure sore. Throughout his stay, he received intravenous cloxacillin and amikacin, piperacillin/tazobactam, cefepime and ampicillin/sulbactam which were appropriate for his tissue cultures. After almost six weeks of tedious care in our ward, his pressure ulcers have improved to grade one, involving a smaller area on his temporals, chest and hip. He was also more alert and was able to tolerate orally. Blood parameters showed resolution of AKI and reduction of CRP to 17 mg/L. He was transferred to a rehabilitation hospital for his stroke recovery with bisoprolol 1.25 mg daily, apixaban five mg twice daily, NeuroAid II two capsules three times daily, atorvastatin 40 mg at night and pantoprazole 40 mg daily.
His baseline blood investigations and liver function tests at the rehabilitation center were normal, ALT was 77 IU/L, ALP 85 IU/L and TSB 5 μmol/L. However, 1 month after the transfer, during a routine wound dressing and follow-up, the liver enzymes were deranged, where his ALT was 146 IU/L, AST 58 IU/L, ALP 77 IU/L and TSB 8.7 μmol/L. He was clinically asymptomatic and was not jaundiced, his blood pressure was 100/80 mmHg and pulse rate was 50 beats per minute. Screening for hepatitis B and C were negative. Hence, the statin, beta blocker and pantoprazole were withheld. Low dose digoxin was started as rate-control medication for his AF. An ultrasonography (US) of the hepatobiliary followed by computed tomography (CT) of the abdomen showed a huge simple liver cyst at segments two and three measuring 8.1 × 6.4 × 5.6 cm (Fig. 3). We, therefore, referred him to our surgical colleagues, who offered surgical resection. However, as the family was not keen for surgical intervention, we continued to follow him up to monitor his liver enzymes.
Axial a and coronal b cut computed tomography (CT) of the abdomen showing a well-defined hypodense mass in segment 2 and 3 (red arrows) of the liver that is suggestive of a simple liver cyst
Despite cessation of statin, beta blockers and proton pump inhibitors for two weeks, his liver enzymes continued to increase, ALT was 210 IU/L, AST 85 IU/L. His renal profile was normal, with urea 5.7 mmol/L and creatinine of 57 μmol/L and CRP was not elevated, at 3.6 mg/L. His pressure sores have very much improved to grade one, blood pressure was 100/85 mmHg, pulse rate was 55 beats per minute and ECG showed evidence of rate-controlled AF. As the septic parameters were not raised, with no clinical evidence of infection and hemodynamic stability, this precludes our suspicion that the raised transaminitis was due to an infection. Though there have been some reports on the derangement of liver enzymes during the acute phase of ischemic stroke; however, they tend to plateau and normalize by day seven, which obviates the transaminitis as an acute phase reactant in our case [9, 10]. However, due to concerns of worsening liver profiles, we decided a trial of withholding NeuroAid II. Within 5 days, his ALT reduced to 90 IU/L and AST reduced to 44 IU/L, after 2 weeks of stopping NeuroAid II, his liver enzymes returned to normal. The patient continued to improve and was able to ambulate with a walking frame. As the liver enzymes normalized and patient was asymptomatic, he declined a repeat imaging to reassess the liver cyst.
Acute reperfusion therapy by thrombolysis or thrombectomy is limited to a small subset of patients due to short window of treatment time and several contraindications [11, 12]. Beyond this time window, treatment for stroke is limited to optimizing medical therapy to prevent future stroke alongside rehabilitation and physiotherapy. However, more recently, in vitro and in vivo studies have shown that NeuroAid II is able to potentially reverse ischemic tissues in the brain and promote neurogenesis [13,14,15]. Although multiple studies have proved its efficacy and long-term safety profile [16,17,18], these studies excluded patients who had concomitant anticoagulation onboard [19,20,21]. As NeuroAid II consist of herbal contents, its use is licensed as Food Supplements as opposed to Drugs in many Asian countries; including Malaysia. Thus, patients' consent is not required for consumption of this drug in our country [22, 23].
Despite that, Kong and colleagues showed an alarming trend of hepatotoxicity and jaundice in patients taking NeuroAid II, causing them to withdraw from the study [20]. Other studies demonstrate milder side effects, especially nausea and vomiting [24, 25]. This effect is greatly magnified by several risk factors, such as elderly age group and a more severe stroke [26]. This poses a significant dilemma in treating cardioembolic stroke who present outside of the therapeutic window, as these patients will need indefinite anticoagulation to prevent a recurrence of stroke.
With the emergence of non-vitamin K antagonist anticoagulant (NOAC) in stroke prevention in AF, warfarin has fallen out of favor [27]. The efficacy and safety of these drugs are well tolerated and they are widely used in clinical practice to date [28]. Major adverse effects with NOACs were bleeding tendencies [29,30,31]. Although in these trials, there was a small proportion of patients with hepatotoxic effect, it was the same in both NOAC groups as compared to warfarin. There have been several case reports on the hepatotoxicity of NOACs, but they are very rare with a frequency of 0.1–1%. In these reports, hepatotoxicity occurs more often with rivaroxaban as compared to apixaban and dabigatran, although the exact mechanism is still unknown [32, 33]. Although beta blockers are also associated with deranged liver enzymes [34, 35], the fact that we have stopped the beta blocker with no improvement in liver enzymes ruled the bisoprolol as a causative agent for the transaminitis.
Putting the evidence into perspective, the risk versus benefits in starting medications and co-administration with other drugs needs to be taken into serious consideration. The choice of drug which will provide the best outcome with least side effect should be initiated. In our patient, for instance, the administration of anticoagulant was essential for future stroke prevention due to his underlying AF. As such, we were reluctant to stop his anticoagulation. Furthermore, large trials have proven the safety of NOACs with co administration of multiple drugs [36], which was not fully explored in many NeuroAid trials. Therefore, we decided to stop NeuroAid II while maintaining the anticoagulation.
The cessation of NeuroAid II showed a dramatic improvement in the liver function with normalization within 2 weeks of stopping the drug. What's more, the NOAC was successful in preventing the recurrence of stroke and with rehabilitation on board, he was able to ambulate with a walking aid and resume his activity of daily activities with minimal assistance. This was an important outcome for him and his family to achieve, as it improved his quality of life and reduced his dependency. Since the studies on the efficacy of NeuroAid II was not proven to be affective beyond the period of 3 months, it was discontinued indefinitely for our patient.
Most simple liver cysts are benign and present with a picture of cholestasis [37]. Although the size of the liver cyst was big, the CT of the abdomen did not show any evidence of biliary tree obstruction nor did the blood parameters show any evidence of cholestasis. Nonetheless, there is a possibility of the liver cyst causing the transaminitis. In this context, a follow-up imaging of the abdomen was crucial to establish this effect. Unfortunately, we were unable to proceed with a repeat imaging as the patient declined further follow-up as he remained asymptomatic and due to logistics issues. However, due to the temporal relationship on initiating and stopping the Neuroaid II in causing and resolution of transaminitis, we could not confidently rule out the association of NeuroAid II especially in combination with other drugs causing the derangement in liver enzymes.
The hepatotoxicity side effects of TCM has been widely reported, although its causative mechanism and underlying pathophysiology is difficult to determine [38, 39]. This is due to the fact that these TCMs are manufactured as a combination of several herbal compounds, thus pointing to a particular compound that may cause harmful effects remains a challenge [40, 41]. Furthermore, these harmful side effects are magnified by patients' factors, such as older age group, more severe stroke and polypharmacy that may worsen the hepatotoxicity.
The strengths of this case report are the new finding of hepatotoxicity of an anticoagulant with NeuroAid II and its strong temporal relation between the resolution of transaminitis with the cessation of the drug. This is important as anticoagulant is the mainstay treatment for cardioembolic stroke. However, the strength of evidence is limited as this is a single case report reporting such association.
In conclusion, treating stroke in the elderly age group remains a great challenge. Due to higher risk factors and comorbidities, this subgroup is more prone to receive multiple medication for underlying illnesses. The risk of polypharmacy is thus amplified in this population. This case highlights the potential harmful effect of administering NeuroAid with an anticoagulant or polypharmacy and the importance of routine follow-up and blood monitoring in the elderly patients with stroke.
The data sets supporting the conclusions of this article are included within the article.
MCA:
Middle cerebral artery
BDNF:
Brain derived neurotrophic factor
TCM:
Traditional Chinese Medication
NIHSS:
National Institute of Health Stroke Scale
ECG:
MRA:
Magnetic resonance angiography
WCC:
White cell count
TSB:
Total serum bilirubin
Alanine aminotransferase
AST:
Aspartate transaminase
AKI:
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We would like to thank the Director of Hospital Pengajar Universiti Putra Malaysia for encouraging and allowing the production of this case report.
Department of Neurology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia
Anna Misya'il Abdul Rashid, Abdul Hanif Khan Yusof Khan, Wei Chao Loh, Janudin Baharin, Azliza Ibrahim, Liyana Najwa Inche Mat, Wan Aliaa Wan Sulaiman, Fan Kee Hoo & Hamidon Basri
Institut Penyelidikan Penuaan Malaysia (MyAgeing™), Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia
Anna Misya'il Abdul Rashid
Faculty of Medicine, Universiti Teknologi MARA, 47000, Sungai Buloh, Selangor, Malaysia
Fazah Akhtar Hanapiah
Department of Radiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia
Mohamad Syafeeq Faeez Md Noh
Abdul Hanif Khan Yusof Khan
Wei Chao Loh
Janudin Baharin
Azliza Ibrahim
Liyana Najwa Inche Mat
Wan Aliaa Wan Sulaiman
Fan Kee Hoo
Hamidon Basri
AHK, WCL and JB was involved in the literature search as well as obtaining consent. AM and FA was involved in the layout and writing of manuscript as well as obtaining clinical information. MSF was involved in the acquisition of the radiographical images. FKH, WA, LA and HB were involved in critical analysis of the manuscript as well as formatting and editing the manuscript. All authors read and approved the final manuscript.
Correspondence to Anna Misya'il Abdul Rashid.
The authors' institution does not require ethical approval for publication of a single case report. Written informed consent was obtained from the patient's next of kin (children).
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.
The authors declare that they have no competing interest.
Abdul Rashid, A.M., Md Noh, M.S.F., Yusof Khan, A.H.K. et al. NeuroAid II (MLC901) and polypharmacy in stroke and the risk of hepatotoxicity: a case report. Egypt J Neurol Psychiatry Neurosurg 57, 151 (2021). https://doi.org/10.1186/s41983-021-00397-y
DOI: https://doi.org/10.1186/s41983-021-00397-y
Chinese traditional medication
NeuroAid II


text:
Engineer-turned-artist Wiwat Kamolpornwijit creates extremely lightweight jewelry from polymer clay, silver and beads. Photo credit: Kamolpornwijit.com
Photo: Kamolpornwijit.com
Southern Made: These are not just-for-mom gifts
Southern Made
Linda Jerkins, For the AJC
MODERN EDGE
Engineer-turned-artist Wiwat Kamolpornwijit uses polymer clay in his contemporary jewelry designs.
The artist: Kamolpornwijit grew up in Thailand, where he attended an engineering college. He moved to the United States to attend graduate school at New Jersey Institute of Technology and worked as an environmental researcher at Oak Ridge National Laboratory in Tennessee for six years. At a fundraising event for his temple in 2004, he started playing with polymer clay. Three years later he opted to pursue his art full time. Kamolpornwijit lives in Alexandria, Va.
The goods & materials: Extremely lightweight jewelry made from polymer clay, silver and beads.
The process: The artist forms each piece of polymer clay by hand and uses several techniques in his designs, including caning, engraving, weaving and layering. All colors are the original colors of clay (no paint is applied). Beads and wires are added to complement the clay work.
What's popular: Designs in black and white (under $100). Also earrings ($35 to $195) and necklaces ($45 to $700).
Claim to fame: Exhibited for the first time at the 2018 Smithsonian Craft Show last month in Washington, DC.
Fun (or unusual) request: "When someone asked me to say my name really fast."
Where to buy: Kamolpornwijit.com. Also at popular Artisphere festival in Greenville, S.C., May 11-13 (artisphere.org).
Atlanta's Teri Xerogeanes creates eco-chic candle collections — from 30A to Blue Ridge — that bring to mind a favorite getaway.
UNCOMMON SCENTS: Atlanta's Teri Xerogeanes creates eco-chic candle collections that bring to mind a favorite getaway. Photo credit: WaxCandleBar.com
Photo: WaxCandleBar.com
The company: Wax Candle Bar, based in Atlanta, started in 2017. The company invites customers to customize a candle by choosing the container, the wax (soy, bee or coconut), and the scent (from more than 16 fragrances).
The founder: Teri Xerogeanes grew up in Michigan and graduated from Ferris State University. After college, she worked for Pfizer and moved to Atlanta in 1993. She first began making candles for herself, then as gifts for friends. A holiday trunk show helped kick-start her business.
What's popular: Summer Fig is the top fragrance. For containers: the St. Simons ($55) and Cloister ($60) with mercury glass finishes. Also the Lanier ($45) and Reynolds ($55) in birch-wrapped bowls.
Other favorites: The Atlantan ($90), a large, black metal bowl with a gold interior finish. The container holds almost 4 pounds of wax and has four wicks.
What's new: Wax Candle Bar's Refill Bag ($25). The DIY kit includes 2 pounds of soy wax, fragrance, two wicks, a wax wand for stirring and instructions.
Where to buy:WaxCandleBar.com. In Atlanta, at EcoHome Atlanta, 2385 Peachtree Road, (ecohomeatlanta.com) and Sugarcoat, 4365 Roswell Road.
Southern meets modern science in Savannah-based Sapelo Skin Care.
The founders: Stephanie Duttenhaver and Cindy Edwards. Duttenhaver grew up in Savannah and earned a marketing and management degree from Armstrong State University. Edwards, a University of Georgia grad, is from Claxton. The women, who met working on a community event, decided to team up on a new, healthy skin care line.
Southern meets modern science in Savannah-based Sapelo Skin Care. Photo credit: SapeloSkinCare.com
Photo: SapeloSkinCare.com
The company: Sapelo Skin Care started in Savannah in 2012 and launched its first product three years later.
The goods: A luxurious collection of natural skin products created using proven and effective ingredients inspired by the barrier islands off the Georgia coast.
What's popular: Rejuvenating Cream ($240), Spring Tide Serum ($195), and Restoring Eye Serum ($95).
Other favorites: Anti-Aging Enzyme Mask ($75) and Softening Emollient ($95).
Fun (or unusual) request: A collaboration with The Spa at Sea Island's aesthetics team, who asked the company to create a gentle and effective skin nourishing system that was 100 percent safe for pregnant and nursing mothers who were visiting the spa on their "babymoons." The Milk & Honey Collection was born.
Where to buy: SapeloSkinCare.com. In Atlanta, at the Spa at the Mandarin Oriental, 3376 Peachtree Road.


text:
Gaming Commission (Continuing Lotteries Levy) Bill 1999
Long Title The purpose of this Bill is to provide for the imposition of a prescribed levy on continuing lottery tickets. The Bill complements the Acts Amendment (Continuing Lotteries) Bill 1999, which transfers responsibility for the licensing and regulation of suppliers of continuing lottery tickets from the Commissioner of State Revenue to the Gaming Commission so that only one government agency is responsible for the licensing and regulation of continuing lotteries in Western Australia.
Royal Assent given 11 Apr 2000 as Act No. 5 of 2000. Different sections of this Act come into operation on Royal Assent and Proclamation. For details refer to Commencement Clause of the Bill (see also Assent and Commencement information for Acts)
Second Reading Agreed 15 Mar 2000
Third Reading 15 Mar 2000
First Reading 16 Mar 2000
Second Reading 16 Mar 2000 2
2. Cognate debate with the Acts Amendment (Continuing Lotteries) Bill 1999.


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Red and itchy skin, cough and sneeze around an allergen -means you are having allergy! Such a awful and frustrating condition. When your immune system interacts with an allergen (foreign substance) like bee venom, pet dander or a pollen, it causes a exaggerated allergic reaction in a sensitive body. Although many individuals outgrow allergies gradually, but it can affect any person at any age.
Immune system is a complex system that normally defends your body against foreign elements and substances such as viruses and bacteria. This system produces substances known as antibodies which stops and kills unwanted invaders that could make you ill or cause an infection. When you have a defective yet sensitive immune system, it makes you allergic to certain substances. When you come contact to that allergen, it can cause you get some sort of allergic response, which may make you cough or sneeze, inflame your skin etc.
The word allergy was originated as ''Allergie'' in Greek language. The word ''allergy'' was first used in 1906, by Clemens von Pirquet. To get an allergy is a common phenomenon. About 20% of the people are affected by allergic rhinitis, 6% of people have atleast one or more food allergies, 18% people have asthma, 0.05-2% of the people have anaphylaxis and 20% people have have atopic dermatits.
Immune system is a vast system that helps to protect your body against invading pathogens and invaders. When a harmless substance enters in your body, sometimes, the immune system makes a mistake and consider it as a harmful pathogen. The immune system automatically starts to make antibodies for that particular agent. Now, when you are exposed to that agent again, those antibodies that were produced before, releases a number of chemicals to kill that harmless substance. These chemicals are the reason for the allergic reaction.
Some foods, such as tree nuts, milk, eggs, shellfish, soy, fish, wheat, peanuts and beetle nut.
Airborne allergens, particularly pollen, dust mist, mold and animal dander.
Insect stings such as bee stings or wasp stings.
An allergy symptoms depend on the allergen upon which immune system has shown a drastic response. The allergic response may be severe or mild.


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In Scientology, the security check (or sec check) is an interrogation technique put into practice by founder L. Ron Hubbard in 1960. It involves an "Ethics officer" probing the thoughts, attitudes and behavior of an individual member by asking them large numbers of questions. The bulk of the questions deal with criminal or sexual activity or intentions, or other things that the interviewee might be ashamed of. The questions also probe negative thoughts that the person might have about Scientology or Hubbard. As with "auditing", the subject holds the electrodes of the E-meter, a pseudoscientific device that measures electrical conductivity in the human body, while they are given a series of highly probing, personal questions.

Hubbard described security checking as a remedy for "unreasonable action", specifically "the compulsion or obsession to commit actions" the person feels must be kept secret. Checks are given to all Scientologists on the Bridge to Total Freedom, every six months to all Operating Thetans, according to officials, "to make sure they're using the tech correctly", and to members who are leaving staff.

In a "Code of Reform" issued in 1968, Hubbard announced that he was cancelling security checks, along with the policies of Fair Game and Disconnection. However, later Scientology documents refer to the practice, and former members report that it still continues.

Sec Checks are also known within the Church of Scientology as "Integrity Processing" or "Confessional Auditing".

Security checks
A security check resembles the confessional in traditional religions. However, it also differs from them in that it is not voluntary. Hubbard told security checkers that "you are not merely an observer, or an auditor, you are a detective."

Susan Raine of the University of Alberta observes that the questions asked in security checks show that L. Ron Hubbard was intensely preoccupied with scrutiny, surveillance and betrayal. She notes that this intense form of surveillance makes sense from a bureaucratic perspective as a way of making sure all individuals follow (and internalize) the organisational goals. Bent Corydon, an ex-Scientologist, compares security checking to the use of thought police in the novel Nineteen Eighty-Four. He writes that Scientologists are punished for having negative thoughts about Hubbard or Scientology and so learn to think only positively. David Mayo, another former member, reported that sec checks included the question, "Have you ever had any unkind thoughts about LRH?" and that such "discreditable thoughts" could land a follower in trouble.

In 1972, the South African Commission of Enquiry published a report on Scientology. It recommended that there should be legislation against sec checks. However, no legislative action was taken as a result.

HGC Pre-processing Security Check
HGC stands for "Hubbard Guidance Centre". Sociologist Roy Wallis quotes some questions from this security check dating from 1961.
Are you a pervert?
Are you guilty of any major crimes in this lifetime?
Have you been sent here knowingly to injure Scientology?
Are you or have you ever been a Communist?

Johannesburg Security Check
The Johannesburg (also known as "Joburg") Security Check  was described by Hubbard as "the roughest security check in Scientology". An amended form continued to be used for some time thereafter.

Amongst Hubbard's list of primarily crime-related questions is the question "Have you ever slept with a member of a race of another color?" Other questions include:

Have you ever embezzled money?
Have you ever been a drug addict?
Have you ever bombed anything?
Have you ever murdered anyone?
Have you ever raped anyone?
Have you ever had anything to do with a baby farm?

Only Valid Security Check
The contents of the Joburg security check were later revised into what became "The Only Valid Security Check". Added to the Sec Check are new questions such as:
Do you collect sexual objects?
Do you have a secret you are afraid I'll find out?
Are you upset by this security check?
Have you ever had unkind thoughts about L. Ron Hubbard?Hubbard, L. Ron (1961) "The Only Valid Security Check" Hubbard Communication Office Policy Letter, 22 May 1961

Auditor's Sec Check
This sec check, comprising 170 questions, was meant for staff auditors and field auditors.
Do you hope you won't be found out?
Do you think there is anything wrong with having your privacy invaded?
What do you wish you hadn't done?
Are you upset by this security check? Hubbard, L. Ron (1961) "Auditor's Sec Check" Hubbard Communication Office Policy Letter, 7 July 1961

Security Check Children
Designed to be applied to children aged 6 to 12. Issued by Hubbard as HCO Bulletin of 21 September 1961, also known as HCO WW Security Form 8. The procedure runs through 100 questions, such as:

What has somebody told you not to tell?
Have you ever decided you didn't like some member of your family?
Have you ever taken something belonging to somebody else and never given it back?
Have you ever pretended to be sick (ill)?
Have you ever made yourself sick (ill) or hurt yourself to make somebody sorry?

Whole Track Security Check
This long Sec Check, consisting of hundreds of questions, takes stock of the subject's entire time track, including their "recollections" of any "past lives" they believe they have had. It includes questions such as:
Did you come to Earth for evil purposes?
Have you ever smothered a baby?
Have you ever enslaved a population?
Have you ever destroyed a culture?
Have you ever torn out someone's tongue?
Have you ever zapped anyone?
Have you ever eaten a human body?
Have you ever made a planet, or nation, radioactive?

Controversy

Potential blackmail

Scientology researcher Jon Atack — a critic of Scientology, and himself a former Scientologist  — explains in his book A Piece of Blue Sky that sec checks could be applied either as a "confidential" confessional or as a non-confidential investigation. He alleges that former members have been silenced by the fear that their "confidential" secrets will be used in blackmail against them.

References

External links

Security checks
Religion-related lists


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MAPS & LEGENDS by Jenn McCreary
Andrew Lundwall's Scantily Clad Press has just published Jenn's new e-chap, entitled Maps & Legends: Here's a taste:
There is a dark path through the dark
woods & it leads to a dark
house lit only by a fireplace
& there lives the crone. Go inside & she will
offer you her secrets.
She will tell you
three things & the third thing is: the owls
are not what they seem. The second thing
is: dragons don't dance & they don't smoke
cigars. The first thing is: when you are dead,
you may have all the ponies you want.
Read the whole book here!
Israel's Economic Stimulus Plan for Gaza
After almost a year of collective punishment that prevented Gaza's citizens access to work, food, fuel and medicine, Israel's recent offensive in the Palestinian territory has given at least one industry a big boost.
CALL IN RADIO SHOW WITH ISH KLEIN AND HAILEY HIGDON THIS FRIDAY FOR NEXUS!
(below is the e-mail Ish and Hailey are sending around
posted here by CAConrad)
THIS FRIDAY! THE BEST RADIO SHOW EVER!! (really, i promise)
On Friday January 30th from 12-5pm, be prepared to listen to the GREATEST 5 hours of radio you will ever know, or at least the greatest ATTEMPT to make it the greatest 5 hours of radio you will ever know!!
We have so much planned, including: interviews, call in poems and rants, sounds (many types), talking objects, invented scenarios, coin tosses, music, accents, extemporaneous poems, themes (many types), and a chicken timer that we will not use to humiliate you.
WHEN: January 30th, 2009, 12-5pm
WHERE: AM 1650 Nexus Radio! LISTEN IN! CALL IN! (215) 684-1946
WHAT: People's Poetry Call-In Show and Variety!
WHO: Ish Klein and Hailey Higdon
Call us, let's make a poem together!
Rant about whatever you want!
Answer interview questions!
Call in and read your poems! Play your songs! Tell us your ideas!
Come and be on the air in person! Really! Tell us the time and we'll schedule you and introduce you! If you're getting this email, it is an invitation to share your poetry! Come by or call in!
UNION! by Ish Klein
Ish Klein's AMAZING first book is NOW AVAILABLE! Click HERE for details!
is the H in HBO for HOMOPHOBIC? Hmmmmmm!
HBO had exclusive rights to film the events of Obama's inauguration at the Lincoln Memorial, and, LO AND BEHOLD, filmed everything EXCEPT the remarks and prayer by openly gay Episcopal Bishop Eugene Robinson: NO video and NO audio was recorded by HBO!!
LUCKILY someone in the crowd filmed Robinson's remarks and sent them to Amy Goodman, who aired the entire footage on DEMOCRACY NOW, using the tag, "...Robinson Silenced on HBO...."
Obama's inaugural committee apologized, stating that they had INTENDED for Robinson's remarks and prayer to be filmed with the rest of the events, and that they "regretted the error." Hmmm, error?
Click HERE to read the transcript from DEMOCRACY NOW, and/or view the footage.
Click HERE to COMPLAIN to HBO and DEMAND ANSWERS! Was is it the cameraman's doing? Was this a decision from HBO headquarters? WHO made this decision? WHO said, "LET'S NOT FILM THIS QUEER, BUT EVERYONE ELSE INSTEAD!" Because SOMEONE said it!
It IS clear however (at least it seems clear) that Obama's people DID MEAN for the Bishop's remarks and prayer to be filmed and aired on HBO.
PoemTalk #13: "The Cars" by KATHLEEN FRASER
PoemTalk that I did with Kristen Gallagher, Jessica Lowenthal and Al Filreis on Kathleen Fraser's poem "The Cars" is HERE. The prose poem itself is also included at this link.
I'll be reading at the SAM BARROW & FRIENDS event Monday, should be LOTS OF FUN AND HOPE TO SEE YOU THERE, details HERE. It will be my first reading from my book JUST ARRIVED FROM THE PRINTER, THE BOOK OF FRANK.
"Barack's as Irish as was JFK"
44's great-great-great grandfather braved the journey to Ellis Island from Moneygall, Ireland back in 1850. Today the small village in County Offaly has a school, a post office, a church, five shops, a police station and two pubs.
A celebratory tune has spread across Ireland claiming that the White House now is green. Hear & see "There's No one as Irish as Barack Obama" by the Corrigan Brothers.
OVER HERE Official Release
Today (January 15) is the official release date of OVER HERE, from Factory School's Heretical Texts Series.
From the FS catalog:
OVER HERE is a collection of works written for farewell parties in the era of endings. These poems are culled from notebooks kept during imaginary road trips across the late empire, serving as toasts to new futures. Come inside for a strange celebration, and watch for sparks.
It's now available from SPD Books. Check it out here.
Moles Not Molar & Nexus RADIO, Jan 18th
Moles Not Molar & Nexus RADIO present
RADIO MOLES - Transmissions: Signal to Noise Ratio
1650 AM on the radio dial!
This Sunday, January 18th 2009
2pm -5pm (live performances will begin promptly at 2:30 pm)
at NEXUS GALLERY
located in the Crane Arts Building
A full afternoon program of radio plays, poems, sound art,
speeches, songs, sonic experiments, acoustic beating, sawhorse-
lassoing, shortwave irdials, and more.
Including Live Performances by:
JANET NEIGH, JAMIE TOWNSEND, GREGORY LAYNOR, KIM GEK LIN SHORT,
TIMOTHY LEONIDO, and PATRICK LUCY.
And Transmissional Works By:
AMAR RAVVA, AMINA CAIN, AMANDA DAVIDSON, BEN HOLTZMAN, JASON
CANDLER, BENEATH THE LAKE, JUDITH JORDAN, MIRANDA MELLIS,
CHRIS NAGLER, KATE BROWN, KATE DOLLENMAYER, JOSHUA GOLDMAN,
JON RUTZMOSER, TRISTAN DAHN, THE NOTHING FACTORY, HEIDI
CUNNINGHAM, NICHOLAS OTT, & MISSOULA OBLONGATA.
For more info on Nexus Radio and a full schedule of events, go
to www.nexusphiladelphia.org
For more info on Moles Not Molar, go to www.molesnotmolar.com
-- posted by R Eckes
no better way to celebrate His birthday...
...than to celebrate the latest achievements of our incredible friends!
The AMAZING new batch of Factory School books:
Over Here, by Frank Sherlock (104 pages)
RIGHT NEW BIOLOGY, by kathryn l. pringle (80 pages)
Slosh Models, by Brett Evans (88 pages)
Hegemonic Love Potion, by Jules Boykoff (104 pages)
Censory Impulse, by Erica Kaufman (94 pages)
Pub Date: Jan 15, 2009
All books $15 paperback, $30 hardcover -- available Jan 15, 2009 through Small Press Distribution (www.spdbooks.org).
VOLUME DISCOUNT: Get a complete paperback set of HT Vol. 4 for $50 (33.3% discount). Order direct from Factory School using PayPal. To order by check, please contact the editors. Factory School's discounted price includes shipping to the continental USA. Individuals only.
For more on the HT series, visit FACTORY SCHOOL
For general info, please write to editors at bmarsh@factoryschool.org
On the birthday of Gladys and Vernon Presley's surviving twin son Elvis, middle name Aaron after his brother Aaron who died at birth. 8 of January, 8 to signify Saturn, ruling over Capricorn, now in the Sun ascending, over Graceland, Philadelphia, over the world. MUCH LOVE,
"When I first heard Elvis' voice I just knew that I wasn't going to work for anybody; and nobody was going to be my boss...Hearing him for the first time was like busting out of jail." --Bob Dylan
Reading at Brickbat January 7th
This Wednesday, Jan. 7th at 7pm
at Brickbat Books, 709 S. 4th St:
Mickey Hess
Chad Willenborg
- posted by R. Eckes
OPEN LETTER to Rick Warren's new friend Melissa Etheridge
Dear Melissa Etheridge, it seemed like good news that you had met with Pastor Rick Warren to confront him on his homophobic disinformation campaign. It makes sense that many thoughtful, open-minded people are thinking that your meeting with Warren made for a good, productive meeting of the minds. Many of these same people worked VERY HARD to get Mr. Obama elected, so the idea of him CHOOSING an openly homophobic anti-Semite like Warren to give "the blessing" at his inauguration to set the spiritual tone of his presidency is a very difficult thing to wrap our minds around. Our feeling of betrayal is appropriate.
To be honest Melissa I have no idea how much experience you have with Fundamentalist Christians, but they're called FUNDAMENTALIST for a reason. When you say you are interested in peace I don't doubt you for a minute. But when you say we should volunteer to be more visible it's nothing but weird to me. Your direct quote is, "Maybe if they get to know us, they won't fear us." But we queers don't grow on trees on a faraway island. Fundamentalist Christians deal with us all the time because we live in their towns. They gave birth to us, we are in their families, and we don't need to visit because we're already there. They know us and we know them, quite well.
From my own experience and understanding with Fundamentalist Christian relatives, there are some who will not allow me to use their towels or toilets because I'm queer. You wouldn't be allowed to either, no matter how many CDs you've sold. Never mind gay marriage, you can't take a shit! And these are people who LOVED me dearly when I was a boy. I FELT their love, and remember it well. And I also remember how painful it was to let them know I was queer, having grown up hearing their sadistic vitriol. My options were to hide or come out. Hiding is an option only for the true masochist, and I am not one. A relative said to me, "You were such a handsome boy, we had such hope for you." In an instant I became someone who was now ugly and without hope.
If I die tomorrow some members of my family will say, "We know where he's headed!" These are extremely unreasonable and uncompromising people, and their bible backs them up one hundred percent. I've read these passages, I've had them read to me. Queers are an abomination, period. We can serve all the soup in the world to all the homeless of the world but we're still going to Hell. The bible says so, period. And Rick Warren can say Jews and queers are going to Hell as gently as he can, but he still says it, and in doing so he makes Jews and queers subhuman animals not worthy of God's love. We are refuse, and THAT is the very kind of philosophy which encouraged Aaron McKinney to torture and murder Matthew Shepard. THAT is the very philosophy which permitted Roland Button to run over Erika Keels four times with his car, and the very philosophy that made her so invisible and inhuman that Philadelphia police wrote her death down as an accident, which remains classified an accident to this day. Despite the medical examiner's report, despite witnesses, despite petitions and marching and demonstrating on behalf of this 20-year old African American transwoman, her murderer has never stood trial, see this: http://www.petitiononline.com/ErikaK/
My boyfriend Earth was murdered in Tennessee. His twin brother who still lives in Philadelphia told me his hands were tied behind his back, he was dowsed with gasoline and set on fire. Over and over I asked, "HOW could they do this!!!!? HOW could they do this!!!!?" But we all know how, we know exactly how. Whoever murdered him was able to find the necessary apathy from a legacy of hate, a legacy of PERMISSION, handed down from church to church, quoting verse to sanction and spur their actions.
In Adolf Hitler's Germany the clergy who used the pulpit to spread hatred of Jews and Homosexuals were doing so to ease the troubled conscience, to act as a link to the voice of God to ORDAIN The Holocaust. Ask yourself how guilty are these men who used their positions of respect and their aura of holiness to push their trusting congregations to commit such atrocities?
Rick Warren is the author of one of the best-selling hardcover books in publishing history. And this is a country where he should be allowed to express himself freely, but so should we be allowed to counter it, to let the voice of reason break through. Millions of people trust and absorb Warren's message that Jews will burn in Hell, and that queers are not FIT to be treated the same as decent heterosexual Christians. Melissa why do you ask US to volunteer in his church? Why not ask these Fundamentalist Christians to volunteer at gay community centers and the queer suicide hotlines? Instead of asking US to show how worthy we are, how about they be asked to prove their worthiness for a change? It is WRONG to grovel up to them for acceptance, for these are the people who pushed US away in the first place, remember? The compromises they demand of us are too expensive and would eat us alive.
We need to be LOUD and be LOUD NOW, not to get through to the people who have shunned us and discarded us, but for the young queer people growing up in these repressive, dangerous families. We need to prevent yet more suicides. And it would be nice to prevent gay bashing and murders, but that's a whole long battle which involves centuries of permission to undo. Did you see the movie Borat? The people being interviewed in the film were not actors. There's a man at a rodeo scene who says without hesitation into the camera that "we're working on" being able to hang queers here like they do in Borat's country. The man openly admires hanging queers elsewhere in the world. Some days THE ONLY THING keeping these bloodthirsty people in check in America is their fear of prison and the electric chair, and some days that's all we queers have between our lives and the grave.
In "Homosexuality and Marxism," the great American poet Jack Spicer wrote:
Homosexuality is essentially being alone. Which is a fight against the
capitalist bosses who do not want us to be alone. Alone we are dangerous.
Our dissatisfaction could ruin America. Our love could ruin the
universe if we let it.
Thank you Jack, for that! This ruin to me is transformative, is the Phoenix, and feels nothing less than essential for love to DEMAND its increase. Melissa please don't ask us to prove that we're good people, because if we have to prove it, then how good are the people asking us to prove it? And frankly I'm VERY GLAD that Barak Obama won and not John McCain and Sarah Palin, but at the same time Obama is LUCKY I didn't know he would CHOOSE Rick Warren's blessing BEFORE election day. You'll see me at the inauguration, I'll be the one with the sign that says, "YOU'RE LUCKY I CAN'T TAKE MY VOTE BACK!"
For all those who have suffered and continue to suffer, we must remember Dr. Martin Luther King's words, "The time is always right to do what is right."
poet CAConrad
Atheists Sue to Get Prayer, God Out of Obama's Swearing-In
By Nikita Stewart
A group of atheists, led by a California man known for challenging the use of the words "under God" in recitals of the Pledge of Allegiance at public schools, filed a lawsuit yesterday to bar prayer and references to God at the swearing-in of President-elect Barack Obama.
Michael A. Newdow, 17 other individuals and 10 groups representing atheists sued Supreme Court Chief Justice John G. Roberts Jr., several officials in charge of inaugural festivities, the Rev. Joseph E. Lowery and megachurch pastor Rick Warren. They filed the complaint in U.S. District Court.
Newdow failed in similar lawsuits to remove prayer from President Bush's swearing-in ceremonies in 2001 and 2005.
Roberts will administer the oath of office to Obama at the Jan. 20 ceremony. Warren and Lowery are scheduled to deliver the invocation and benediction, respectively.
Newdow and others also argue that the phrase "so help me God," used consistently in inaugural oaths since the swearing-in of President Franklin D. Roosevelt, should be stricken, saying it is not part of the oath as specified in the Constitution.
Bob Ritter, staff attorney for the American Humanist Association and counsel for the suit, said in an interview that the group could win "as long as the judges uphold the Constitution."
"We think the law is on our side," he said.
Ritter said the lawsuit targets the oath, the invocation and the benediction.
According to the lawsuit, the opening and ending prayers "are completely exclusionary, showing absolute disrespect to Plaintiffs and others of similar religious views, who explicitly reject the purely religious claims that will be endorsed, i.e., (a) there exists a God, and (b) the United States government should pay homage to that God."
full article here: http://www.washingtonpost.com/wp-dyn/content/article/2008/12/30/AR2008123002858_pf.html
//jenn mcc


text:
Home » Expert Advice » Why Being in a New Field From the Start Can Pay Off in the Long Run
Why Being in a New Field From the Start Can Pay Off in the Long Run
By Helen Albert
07/09/2019 - 12 minutes
The field of immuno-oncology has expanded out of all recognition over the last few years. Having co-founded one of the first cancer immunotherapy biotechs — Immatics — CEO Harpreet Singh has seen it all happen. He plans to take advantage of the company's head start to tackle solid tumors with its T-cell redirecting therapies.
Singh co-founded Immatics in 2000 with two fellow academics, Toni Weinschenk and Niels Emmerich, while completing a PhD in immunology at the University of Tübingen in Germany. The decision to found a company was based on discoveries made in the lab of Hans-Georg Rammensee of targets that could be used to develop a variety of T-cell-based immunotherapies for cancer.
The company has gone from strength to strength since then, raising over €350M in private fundraising and partnership deals, and has several drug candidates undergoing phase I/II trials. Singh has guided the research and development at the company as CSO and MD for many years. He was also instrumental in setting up and leading the US office of the company in Houston,
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Disney Channel is a 24-hour family-inclusive network that offers an all-access pass to the biggest Disney stars, larger than life original movies and popular TV shows like K.C. Undercover, Tangled: The Series and Andi Mack! Disney Channel is the exclusive home to your favourite Disney series and the only place to discover new Disney Channel shows in Canada.
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