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Ariad and STA Announce Approval of ICLUSIG™ (ponatinib) in Australia
Cambridge, MA, and Melbourne, Australia, November 24, 2014: ARIAD Pharmaceuticals, Inc. (NASDAQ: ARIA) and Specialised Therapeutics Australia Pty Ltd (STA), today announced the marketing approval of ICLUSIG™ (ponatinib) in Australia by the Therapeutic Goods Administration (TGA).
The Australian Product Information for ICLUSIG states that it is indicated for the treatment of adult patients with:
Chronic phase, accelerated phase, or blast phase chronic myeloid leukaemia (CML) whose disease is resistant to, or who are intolerant of at least two prior tyrosine kinase inhibitors; or where there is a T315I mutation.
Philadelphia-chromosome positive acute lymphoblastic leukaemia (Ph+ ALL) whose disease is resistant to, or who are intolerant of dasatinib and for whom subsequent treatment with imatinib is not clinically appropriate; or where there is a T3151 mutation.
Therapy should be initiated and monitored by a haematologist with expertise in managing adult leukaemias.
"Up to thirty percent of patients with CML become resistant to current therapies, and patients with resistant disease eventually run low on treatment options," said Professor Timothy Hughes, Consulting Haematologist at the Royal Adelaide Hospital and one of the PACE trial investigators. "ICLUSIG will be a valuable new therapy for refractory leukaemia patients and treating clinicians in Australia."
ARIAD submitted its marketing application for Iclusig in the third quarter of 2013 to the Therapeutics Goods Administration (TGA), in Australia. Commercial launch of ICLUSIG is expected to occur early in 2015.
"We are very pleased with the approval of ICLUSIG in Australia and will work closely with STA to make Iclusig available to appropriate Philadelphia-positive leukaemia patients as quickly as possible," stated Harvey J. Berger, M.D., chairman and chief executive officer of ARIAD. "We look forward to continuing our strong collaboration with STA to provide this important treatment option to refractory CML patients in Australia."
"ICLUSIG provides a new treatment option for patients with difficult-to-treat CML or Ph+ ALL who previously had limited therapies available to them," said Carlo Montagner, chief executive officer at STA. "We look forward to the Pharmaceutical Benefit Advisory Committee's decision on ICLUSIG's reimbursement for Australian patients under the Pharmaceutical Benefits Scheme."
The TGA decision was based on results from the pivotal Phase 2 PACE (Ponatinib Ph+ ALL and CML Evaluation) trial in patients with CML or Ph+ ALL who were resistant or intolerant to prior tyrosine kinase inhibitor (TKI) therapy, or who had the T315I mutation of BCR-ABL. ICLUSIG demonstrated anti-leukemic activity achieving a major cytogenetic response (MCyR) in 54 percent of chronic-phase CML patients and in 70 percent of patients with the T315I mutation.1,2 MCyR within the first 12 months was the primary endpoint of the PACE trial for chronic-phase patients.1,2
In patients with advanced disease, 57 percent of accelerated-phase CML patients and 34 percent of blast-phase CML patients achieved a major hematologic response (MaHR) with Iclusig. MaHR within the first 6 months was the primary endpoint in the trial for patients with advanced disease.1,2
The most common (>1%) serious adverse reactions for Iclusig were pancreatitis, abdominal pain, decrease in platelet count, lipase increased, anaemia, cardiac failure, coronary artery disease, diarrhoea, decreased neutrophil count, febrile neutropenia, pancytopenia, and pyrexia.2 The most common (≥20%) adverse reactions of any severity were decrease in platelet count, rash, dry skin, and abdominal pain.2
CML is a cancer of the white blood cells that is diagnosed in approximately 330 patients each year in Australia.3 CML and Ph+ ALL patients treated with TKIs can develop resistance or intolerance over time to these therapies. ICLUSIG is a targeted cancer medicine discovered and developed at ARIAD. It was designed by ARIAD scientists using ARIAD's platform of computational chemistry and structure-based drug design to inhibit BCR-ABL, including drug-resistant mutants that arise during treatment. ICLUSIG is the only TKI that has received an approval in Australia for an indication that includes CML and Ph+ ALL patients with the T315I mutation.
For further information, please consult the full ICLUSIG Product Information.
About CML and Ph+ ALL
CML is characterised by an excessive and unregulated production of white blood cells by the bone marrow due to a genetic abnormality that produces the BCR-ABL protein. After a chronic phase of production of too many white blood cells, CML typically evolves to the more aggressive phases referred to as accelerated phase and blast crisis. Ph+ ALL is a subtype of acute lymphoblastic leukaemia that carries the Ph+ chromosome that produces BCR-ABL. It has a more aggressive course than CML and is often treated with a combination of chemotherapy and tyrosine kinase inhibitors. The BCR-ABL protein is expressed in both of these diseases.
About ICLUSIG™ (ponatinib)
ICLUSIG is a kinase inhibitor. The primary target for Iclusig is BCR-ABL, an abnormal tyrosine kinase that is expressed in chronic myeloid leukemia (CML) and Philadelphia-chromosome positive acute lymphoblastic leukemia (Ph+ ALL). ICLUSIG was designed using ARIAD's computational and structure-based drug design platform specifically to inhibit the activity of BCR-ABL. ICLUSIG targets not only native BCR-ABL but also its isoforms that carry mutations that confer resistance to treatment, including the T315I mutation, which has been associated with resistance to other approved TKIs.
Minimum Product Information ICLUSIG™ (ponatinib HCl)
Indications: Adult patients with: Chronic phase, accelerated phase, or blast phase chronic myeloid Ieukaemia (CML) whose disease is resistant to, or who are intolerant of at least two prior tyrosine kinase inhibitors; or where there is a T3151mutation. Philadelphia chromosome positive acute lymphoblastic Ieukaemia (Ph+ ALL) whose disease is resistant to, or who are intolerant of dasatinib and for whom subsequent treatment with imatinib is not clinically appropriate; or where there is a T3151 mutation. Therapy should be initiated and monitored by a haematologist with expertise in managing adult leukaemias. Contraindications: Hypersensitivity to ponatinib or excipients.
WARNING: VASCULAR OCCLUSION AND HEART FAILURE. Vascular Occlusion: Arterial and venous thrombosis and occlusions have occurred in at least 23% of ICLUSIG treated patients, including fatal myocardial infarction, stroke, stenosis of large arterial vessels of the brain, severe peripheral vascular disease, and the need for urgent revascularisation procedures. Patients with and without cardiovascular risk factors, including patients less than 50 years old, experienced these events. Monitor for evidence of thromboembolism and vascular occlusion. Interrupt or stop ICLUSIG immediately for vascular occlusion (see Precautions). Heart Failure, including fatalities, occurred in 8% of ICLUSIG-treated patients. Monitor cardiac function. Interrupt or stop ICLUSIG for new or worsening heart failure (see Precautions).
Precautions: Actively monitor and manage patients for vascular occlusions, cardiac failure, hypertension, haemorrhage, myelosuppression, hepatotoxicity, pancreatitis and QT prolongation before and during treatment. Interrupt, reduce or discontinue ICLUSIG as clinically indicated (see full PI). Vascular occlusion: Do not use if history of myocardial infarction, prior revascularisation or stroke, unless the benefit outweighs the risk. Monitor cardiovascular status and optimise therapy throughout. Cardiac failure: Monitor for heart failure and treat as clinically indicated. Hypertension: Monitor and treat hypertension to normalise blood pressure. Haemorrhage: including fatalities occurred. Mostly in patients with grade 4 thrombocytopaenia. Myelosuppression: Severe thrombocytopenia, neutropenia or anaemia. Perform complete blood counts every 2 weeks initially. Hepatotoxicity: Including severe drug induced liver injury and fatal hepatic failure. Monitor Liver Function Tests (LFT's) at baseline and at least monthly. Pancreatitis and serum lipase: Monitor serum lipase every 2 weeks initially. QT prolongation: QT prolongation seen with other BCR-ABL inhibitors. Lactose: contains lactose. Special populations: Caution or avoid in patients with moderate to severe hepatic impairment, pregnancy (category D), breastfeeding, the elderly, paediatric patients, driving or operating machinery (see full PI). Interactions with Other Medicines: Caution with concurrent strong CYP3A inhibitors, strong CYP3A inducers, substrates of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) (see full PI). Adverse Effects: Most common (≥ 20%) adverse drug reactions (ADRs): Platelet count decreased, rash, dry skin, and abdominal pain. Most common (> 1%) serious ADRs: Pancreatitis (5.1%), abdominal pain (1.8%), platelet count decreased (1.8%), lipase increased (1.3%), anaemia (1.3%), cardiac failure (1.3%), coronary artery disease (1.1%), diarrhoea (1.1%), neutrophil count decreased (1.1%), febrile neutropenia (1.1%), pancytopenia (1.1%), and pyrexia (1.1%). Other very common (>10%) ADRs: Upper respiratory tract infection, anaemia, neutrophil count decreased, decreased appetite, insomnia, headache, dizziness, hypertension, dyspnoea, cough, diarrhoea, vomiting, constipation, nausea, lipase increased, ALA increased, AST increased, bone pain, arthralgia, myalgia, pain in extremity, back pain, muscle spasms, fatigue, asthenia, oedema peripheral, pyrexia, pain. This is not a full list of adverse effects – refer to full PI for more information on common (>1%) and uncommon (>0.1%) ADRs. Dosage and administration: Monitor and manage cardiovascular risk factors before and throughout treatment. Dose: Starting dose, 45 mg once daily, with or without food. Dose adjustments based on disease response: Consider reducing the dose of ICLUSIG to 30 mg or 15 mg for chronic phase (CP) CML patients who have achieved a major cytogenetic response, especially in subjects at risk of vascular adverse events. Consider discontinuing ponatinib if a haematologic response has not occurred by 3 months (90 days) especially in subjects at risk of vascular adverse event. Dose adjustments for toxicity: Consider dose modification or treatment cessation to manage myelosuppression, vascular occlusion, uncontrolled hypertension, pancreatitis or elevated serum lipase and other severe adverse reactions. Provide haematologic support (platelet transfusion or haematopoietic growth factors) if clinically indicated.
About Specialised Therapeutics Australia
Specialised Therapeutics Australia Pty Ltd (STA) is a biopharmaceutical company dedicated to working with leading pharmaceutical companies worldwide to provide acute care therapies for high unmet medical needs to people living in Australia and New Zealand. The STA therapeutic portfolio and pipeline at present encompasses oncology, haematology, ophthalmology and infectious diseases. STA also has interests in the therapeutic areas of respiratory, dermatology, endocrinology and central nervous system (CNS).
About ARIAD
ARIAD Pharmaceuticals, Inc., headquartered in Cambridge, Massachusetts and Lausanne, Switzerland, is an integrated global oncology company focused on transforming the li
ves of cancer patients with breakthrough medicines. ARIAD is working on new medicines to advance the treatment of various forms of chronic and acute leukemia, lung cancer and other difficult-to-treat cancers. ARIAD utilises computational and structural approaches to design small-molecule drugs that overcome resistance to existing cancer medicines. For additional information, visit http://www.ariad.com or follow ARIAD on Twitter (@ARIADPharm).
This press release contains "forward-looking statements" which are based on management's good-faith expectations and are subject to certain factors, risks and uncertainties that may cause actual results, outcome of events, timing and performance to differ materially from those expressed or implied by such statements. These factors, risks and uncertainties include, but are not limited to the Company's ability to manufacture, and supply STA with Iclusig; the ability of STA to perform the contracted services, such as obtaining pricing and reimbursement approval for Iclusig in Australia; STA's ability to distribute, promote, market and sell Iclusig in Australia; the timing and scope of the marketing authorisations, as well as the level of pricing obtained in Australia; third-party reimbursement; and the timing and success of sales of Iclusig in Australia. These factors, risks and uncertainties also include, but are not limited to: the costs associated with ARIAD's development and manufacturing, commercial and other activities; the adequacy of capital resources and the availability of additional funding; and other factors detailed in the Company's public filings with the U.S. Securities and Exchange Commission. The information contained in this press release is believed to be current as of the date of original issue. After the date of this document, the Company does not intend to update any of the forward-looking statements to conform to actual results or to changes in the Company's expectations, except as required by law.
1. Cortes JE, et al. N Engl J Med. 2013; 369:1783-96.
2. ICLUSIG (ponatinib) Approved Product Information.
3. Leukaemia Foundation, http://www.leukaemia.org.au/blood-cancers/leukaemias/chronic-myeloid-leukaemia-cml.
Tags: lurbinectedin, small cell lung cancer, Zepzelca


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Fraternity Chant Goes Viral in the Worst Way Possible
Written by DiversityInc Staff on March 10, 2015
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Update (3/10/2015 1:03 p.m.): President David Boren of the University of Oklahoma announced that two students were identified as leaders in the Sigma Alpha Epsilon racist chantingvideo. The students were expelled according to Boren stating "that there is zero tolerance for this kind of threatening racist behavior" at the school.
Update (3/10/2015 9:54 a.m.): The University of Oklahoma chapter of the Delta Delta Delta sorority, which had been reported to be under investigation for links to the racist video, said late Monday that they are not under formal investigation. The Tri-Delt national organization said, however, that they are cooperating fully with the university's investigation.
By Michael Nam
The Sigma Alpha Epsilon (SAE) fraternity at the University of Oklahoma found out just how fast a viral video of racist behavior can reap consequences. The video allegedly shows members of the fraternity taking part enthusiastically in an explicitly racist chant using a slur for Black people and referencing lynching:
The response was rapid, as the national headquarters for the fraternity issued a statement closing the Oklahoma chapter. Brad Cohen, the fraternity's national president, said, "SAE is a diverse organization, and we have zero tolerance for racism or any bad behavior. When we learned about this incident, I called an immediate board meeting, and we determined with no mental reservation whatsoever that this chapter needed to be closed immediately. I am proud of my fellow board members because we mean what we say."
Additionally, the university community in Norman reacted rapidly as demonstrations were held Monday morning by members of the student body in repudiation of the actions caught on video, though members of the fraternity apparently left their house Sunday night. The SAE house was reportedly vandalized overnight with the spray painted words "Tear it down," according to local TV station KFOR. Also, early Monday morning, the President of the school, David Boren, released an updated statement via Twitter harshly rebuking the actions of those on the video and detailing the university's official response.
"To those who have misused their free speech in such a reprehensible way, I have a message for you. You are disgraceful. You have violated all that we stand for. You should not have the privilege of calling yourselves 'Sooners.' Real Sooners are not racist. Real Sooners are not bigots. Real Sooners believe in equal opportunity. Real Sooners treat all people with respect. Real Sooners love each other take care of each other like family members.
"Effective immediately, all ties and affiliations between this University and the local SAE chapter are hereby severed. I direct that the house be closed and that members will remove their personal belongings from the house by midnight tomorrow. Those needing to make special arrangements for positions shall contact the Dean of Students.
"All of us will redouble our efforts to create the strongest sense of family and community. We vow that we will be an example to the entire country of how to deal with this issue. There must be a zero tolerance for racism everywhere in our nation."
AVine surfaced on Monday night showing the SAE house mother, Beauton Gilbow, laughing as she repeats the N-word several times while rapping along to a song.
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Many people expect friends and family over their homes during this time of the year. Barry Zito and his agent have other things in mind.
As of Tuesday, the Mets have become an active participant in the 2006-07 Barry Zito sweepstakes, as general manager Omar Minaya and his staff traveled to Southern California to meet with the lefty pitcher in an effort to bolster a pitching staff that will be without Pedro Martinez for almost half of next season.
While the Mets don�t plan on matching the $100 million dollars the Rangers are allegedly offering the 2002 Cy Young Award winner, they are supposedly offering him a five-year $73 million dollar contract that is similar in structure to the contract they would have offered Roy Oswalt if the Astros and Mets would have been able to come to an agreement regarding a trade for the pitcher this past summer.
As well, the Mets have a few aces in their pockets that may lure the former first-round pick to Queens, including Mets pitching coach Rick Peterson, who helped Zito break into the league and David Wright, who has been trying to convince him to come to Flushing. In addition, the fact that the entire national league is unfamiliar with Zito�s curveball may also give the Mets a better shot at signing him than the Rangers, but unfortunately for Minaya and New York, Texas isn�t the only team looking to sign Zito.
Still feeling the loss of Jason Schmidt, who recently signed with the Dodgers, the San Francisco Giants seem just as determined as the Mets in signing the free agent. Even Zito joked about signing with a National League team after spending his entire career with the A�s, making a deal with the Giants or the Mets a bigger possibility.
While many fans believe that signing Zito is crucial if the Mets want to take the NL East again next season, Minaya and his staff haven�t made signing Zito their top priority with pitchers like Jeff Suppan, Brad Radke and Mark Mulder still free agents and still believe that they have enough pitching depth to get by without him. Nevertheless, Minaya believes they must atleast make an attempt to sign him regardless.
"We're definitely going to talk to his agent,� Minaya told MLB.com. �But if it doesn't make sense, we're comfortable with our starting pitching and our overall pitching."


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New Dark 10th Anniversary Contest - Results
Thread: New Dark 10th Anniversary Contest - Results
20th Nov 2022 14:48 #1
Southquarter.com/fms
Location: The Docks
Ok, voting has closed for the contest, and we have a winner.
Congrats to Nomadman, for their mission Intertheft. Excellent job.
Here are the vital stats:
Intertheft (Nomdaman) - 60 votes - 493 total score - 8.22 average score
House of the Architect (TheDataElemental) - 60 votes - 464 total score - 7.73 average score
Thanks to both authors for their missions, I thought they were both extremeley well done, especially considering they are first time authors.
Also, thanks to everyone who voted. There were some great comments included with the votes, I will post those below.
User comments for the mission Intertheft, by Nomadman:
The best possible re-imagining of Thieves Guild, it captured the OM feel perfectly whilst showing off Newdark capabilities, which was what the contest was all about. Couldn't ask for more.
Tighter package than the OM and in generally I feel like this entry was more faithful to the premise of the competition, in my opinion.
Really excellent mission. Great use of space and sound. Many alternating paths available to the player and frequent changes to the setting and surroundings made it constantly fresh and interesting (something the OM struggled with). Architecture and other design elements are expertly implemented and consistently remind one of the quality of a Skacky/Black Parade team mission. I hope to see more from this author.
An okay mission for me. The gameplay and architecture were great, but other than that it felt like a Warming-up of the OM. The same story, the same conversations. I felt bored after playing it for a while.
Making a kinda tedious mission into a fun one is not easy but the author succeeded here. I always love cramped and detailed spaces so that's another plus. And as much as I think that the House of the Architect is a really good mission it did lack at least some kind of story or at least some readables.
Fantastic "retelling" of Thieves' Guild that is better-looking, easier to navigate, and better paced than the original while retaining everything that was interesting in the OM. Hard to believe this is from a new author, it feels polished to a shine. Next time I replay Thief 1, I'll probably slot this mission in instead of the original Thieves' Guild, it's that much better.
A very good re-interpretation of what the thieves guild *SHOULD* have been like. It had the grittyness feel of a real OM TG mission. my only complaint is the fine touches were missed - i.e. plates that are sunk into table tops. for tl/dr > WOW.
This level struck much better balance between openness and intelligibility, and the challenges that it poses are more bearable than in original Thieves' Guild. There are much less samey-looking corridors and sewer tunnels while the layout is divided into small parts that are easily distinguishable one from another. While doing so, Intertheft also remains multi-leveled and - surprisingly for such underground level! - very vertical mission that occasionally puts you into spatial puzzles. Often it proposes you several ways into areas of interest - which is also sign of a quality mission. Sometimes you still can get lost (for me it was objective with obtaining bracelet), but such moments are rare comparing to original Thieves Guild. In general, excellent first mission, and I hope Nomadman would continue!
Enjoyed playing. A little constricted in places. Bewildering map.
Very good reinterpretation of the infamous Thieve's guild mission. Some clever and interesting architecture, specifically in reuben's and donald's mansions. Good encounter design, interesting sneaking opportunities. The layout is a bit cramped in some parts, corridors could be about 20% larger. This is the winner for me.
Very beautiful remake of the Thieves Guild. No critic points at all for me.
A maze that is nicer and less maze-ish than the original.
I was so impressed by this one, I think it serves as a good replacement for the original 'Thieves Guild'-mission.
Thieves' Guild - but fixed. Tightly built, with good flow, chhallenging sneaking, and solid aesthetics.
Very nicely made. Layout is a bit cramped for my liking, but it's only a personal thing. Lot of effort went into small details and I highly appreciate it, I don't like empty, low effort missions, and this is definitely not one. Thank you for the fun and good luck with the contest!
Great game play, good pacing and design, good amount of imagination in expanding the original Thief mission.
Fun to play. A bit too narrow some places.
Very interesting, nicely improving Thief Guild, what has really boring fragemnt. Intertheft: none. I found here great time and Thief atmosphere. One thing: here also too many guards.
I really enjoyed this re-imagining. It is definitely superior to the original experience (Sorry LGS, but I guess that's why it wasn't in TDP). I rated 8 because while it is incredibly technically proficient and I experienced no bugs or issues, it *was* a reimagined OM.
First of all, this is just insanely good author's first mission! So far I'm not sure if I've played before this good author's first mission (maybe Compulsory Egress and Hidden Agenda are at the same level). What impressed me most is the gameplay that feels so solid and the difficulty is just right. It's been awhile since I've played OMs but I think this mission captures the feeling of OMs nicely. Of course this is much more detailed than OMs but still it feels that author's top priority was the gameplay. Also atmosphere and tension are very strong throughout the whole mission!
So, I really hope to see more FMs from this author! It's quite rare to play a mission like Intertheft where the gameplay and difficulty feels just right and everything seems balanced. Very good work!
Great mission, especially for a first-time author. Very well-designed and atmospheric. It was a pleasure to play.
A recreation of the "Thieves' Guild" mission, but with a better-sized (smaller) area. Some locations, though, were a bit too cramped for me, e.g., the sleeping rooms of the thieves, or some of the bosses' houses. The environment still required a notable amount of exploration, and especially looking for things to steal or sometimes information to gain. In the end, I found it to be a bit too much labour for a bit too small a reward in gameplay.
Why exactly I value it slightly less than "House of the Architect", I cannot say, but it most likely is a personal choice. "Intertheft" is still a very notable effort, a worthy competitor to "House of the Architect", and certainly not a bad mission.
Quite challenging mission. Large amount of thieves (expert). Navigation between manors and at the thieves sewers was painful. Only at the end I figured out which manor belonged to whom. However, every exploration was greatly rewarded. As usually when playing FMs, I missed around 1000 loot, so replay is absolutely needed. The story was straightforward, the readables were fun and not long, which I liked. The mission was atmospheric in the way that it reminded me of Alcazar or Into the odd. However, some things I did not like. First of all, the mission felt a little too dark for me, even with gamma set at around 60-70%. Secondly, some parts, like the sleeping rooms at the sewers area, were too cramped and sometimes I was stuck by the bed or body that I needed to reload. Also, I was firstly very confused, that I was given a key for certain door while you could open it with lockpicks.
An excellent remastering of perhaps the least liked mission in the whole series.
Last edited by Brethren; 20th Nov 2022 at 15:11.
User comments for the mission House of the Architect, by TheDataElemental:
A great mission in many ways, the final area was superb, but dropped a couple of points due to the lack of readables. Hoping the author will release an updated version after the contest to flesh out the story.
Great mansion romp with some great twists, what lets it down is the complete lack of readables in my opinion, still a great mission though!
Very creative mission which is deceptively large. The ending sequence is particularly memorable and unlike anything I've seen implemented before. Score would have been higher had some slight sound issues and other bugs been captured in testing and also a lack of readables slightly took away from the otherwise creepy atmosphere. I think more information to provide an element of narrative would have added more to the atmosphere. Overall, a very enjoyable and impressive mission from a first time author.
Pretty cool mission. Nice architecture, thievy feeling & good gamplay. Two Minus points I give for the lack of story and readables.
It's very hard for me to rate this mission. It looks beautiful, there's so much wonderful details. But the story is lacking or atleast some flavour texts. I thought about giving it a 7/10 but that feels kinda wrong so I'll have to give it an 8 as well.
Really fun and imaginative mission; great atmosphere, fun premise. The crazy void towers bit at the end was ace!
I think it could have done with a smaller scale, the rooms all felt just a bit too big, and the lack of readables was problematic because the environmental storytelling didn't carry the mission.
Overall though, fantastic for a first mission (jeez, wish my first mission had been even half this good). Looking forward to seeing more from this author.
I have to rate both missions at 9 - both are EQUALLY worthy of winning. this mission feels huge - lots of different paths, the right amount of guards to raise tension, tight guard patrols. my only issue is the level does't feel it was "finished" i.e. lack of readables. honesly that was my only complaint.. a first time author making something this intricate. - NICE. I would love to see a post content version update that really sit down and try to supreme ghost it.
The mission was clearly meant as mix of Thief 1's opening level and The Sword. But it feels like either overgrown Shadow Play or throwback to era of earlier Thief 1 fan-missions - like Order of the Vine or Mystery Man. The mansion consists of several GIGANTIC floors, full of tile floor, loot, huge rooms and halls and passages between them - obvious and non-obvious. Several exits to mansion. Ways from one floor to another, hidden in plain sight. The mission easily puts tension on the player who should carefully manage attention to marble floor and to guards walking around.
The mission clearly feels like beginner's effort. Sometimes it's too gigantic, and some areas (especially outdoors) are clearly underused and are empty. Some bugs are present - with the disappearance of certain item near the end of mission. There are almost no readables in the mission (I don't think of it as disadvantage though). But it's well done beginner's effort: it's challenging and beautiful and doesn't overstay it's welcome. I hope to see some new creative input from DataElemental.
Great architecture. Really interesting rooms. Gameplay above average.
A very entertaining romp through a huge mansion. This mission is fun and has some very creative and mind bending designs. The mansion is a bit too large for me. The encounter design is less puzzley and more bonkabonkey. This is not a problem, it just means that the map leans more into 'fun' and less into 'challenging'. All in all very fun map!
This mission is simply amazing. I was afraid when I saw the sheer size of the mansion from the outside that it will become repetitive and boring after a few rooms, but boy, I was wrong. When I entered the mansion I thought that it's just a normal mansion even if a bit huge, after that I saw the torture room on the top floor and thought, this guy is insane, then I entered the fire shadow world in the lower parts and realized, this guy is some kind of god to have that in his basement.
I had a great time exploring and there is still much for me to discover, since I finishet some 3000 loot shorter than the maximum.
Thank you for this great mission, it's simply amazing!
An outstanding fan mission. I only wished readables, a map and some note pages were included.
Big nice and absolutely empty place.
Ambitious, some "oversized FPS map" syndrome. It has a lot of character, and a well realised final section.
Great design, good pacing for the game play for a large map. Would love to see the surrounding areas expanded.
Good: Always nice to see some new missions. Had fun playing it.
Suggestions for improvements: Too easy to complete. Unrealistic size ratio of both rooms and inventory.
Majestic mission, full of marvelous details. Really inspiring "upgrade" of original classics. Playing it was fascinating and made me proud, that Thief community is still so alive and creative.
One thing, there were not so much reading, but too many guards.
For a first time author, this blew my mind. I want this mission to win because I want the author to be encouraged to continue their work.
Excellent expansive mansion that looks and plays superbly. I am highly impressed. A re-release of this mission later on to include some readables for added story would put this mission up there with some of the best ever. I didn't find a map, so maybe allowing the player to find a map of the mansion at some point (surely an architect would have one lying around) would also be an added benefit.
This is a very big manor FM, which has some other areas (small streets, sewers and some weirder areas). The manor looks amazing and very creative with lots of different styles and textures. Definitely the strongest point of this FM is the visual side. Only small minus I could say is that after some time the manor doesn't surprise anymore. Maybe there could have been a little more tension in some part of the manor (maybe some others thieves lurking about or something else that surprises the player).
The weird areas had definitely tension that made the gameplay more interesting (meaning the Constantine's manor style areas and the weird world that was below the manor). So, maybe the manor could have been a little smaller and there could have been a bit more of weird areas because they were top-notch. Still the mission is great as it is (even more so for author's first one) and I think many authors can find the mission inspirational! Keep creating more FMs!
A bit like "The Sword" (T1 OM), this mission also sends Garrett into a mansion that gets weirder the deeper he goes into it. The opponents were neither too easy to get rid of, nor were they too much for me. Occasionally, there were moments at which I lured out of sight in order to find an opportunity to pass through enemies, but more often careful exploration was the best behaviour. This is a good mixture for gameplay on easiest difficulty level, which is what I played.
The only two things that were not so good were the large environments with not so many objects, which felt a bit too empty, and not many goals to pursue as well. A tiny little bit more to do, maybe some new objectives or goal changes in the mission, and a small additional dose of objects especially in the larger rooms, and the mission would have felt more "whole". But for a first attempt at building, this one certainly is a good mission.
Nice FM, full of great ideas, however, it feels unfinished (no texts, empty design...)
Maybe a bit too big, with places interesting but useless except for looting
Would definitely be worth a V2
I am playing this mission second in order and have a hard time separating it from the Intertheft by a whole score of 1 or more. Graphically it is a little bit superior than Intertheft (my computer sometimes stuttered when looking up), it includes a large indoor but also outdoor area. The mansion is huge and well interconnected, the "secrets" were various and also here on Expert the guards on marble posed a challenge. Things that I miss: maybe some story, and a couple of readables would be nice. Some corners lacked sound.
Congratulations to both contestants and to you, Brethren! Both missions are very good.
Last edited by michael a; 20th Nov 2022 at 15:48.
A.Stahl
Wow. That's... ghm... discouraging.
fortuni
Actually that's a pretty good number of voters for a contest.
Anyway I hope the authors will now reveal their true identities, both were first time authors and I think we can all agree we would all like to see further missions from both of them.
21st Nov 2022 04:32 #7
Thank you, Brethren. And congratulations to both authors for making enjoyable FMs. I would also love to see more missions from both of you.
Samantha1
Thank you brethren for making this contest and a big thanks to the two authors for their great missions. Both are really enjoyable!
skacky
Location: Lyon, France
Congrats to both contestants! Like Samantha I am definitely keen on seeing more stuff from both of you.
Also, 60 voters is pretty good. That's about the same amount of people rating missions on Thief Guild these days.
frobbin hood
Location: Cragscleft, Bedfordshire, Eng.
I'd like to echo the comments above. Thanks Brethren, for organising it and thank you to the authors for their hard work in producing two excellent FMs.
It's great to see that there is still interest in producing (and playing) this wonderful game.
szabikka
I'm happy that I had the ability to play both of these fantastic missions. Huge thanks for the authors and to Brethren to organise the contest. I hope we will have more contestants and missions next time, the more missions to play, the better .
8th Jan 2023 13:34 #12
Wormrat
Excellent missions, both of these, and yes, I hope both of these authors make more! Some quick comments:
Intertheft: Super well-executed revamp of the concept. It felt realistic and believable how the thieves repurposed the sewers and had their own little culture down there. Tight quarters, twisty passages, lots of sleepers to tiptoe around. Very tense. Practically rubbing shoulders with the thieves at times. Many creative and varied room/trap/challenge ideas along with alternate paths and fun sneaky ways for Garrett to "out-thief the thieves" (although I fumbled things in Donal's place and left it a bloodbath). The author's notes and suggestions in the readme were appreciated.
House of the Architect: If Intertheft is "tight quarters", this is pretty much the opposite! I never really get tired of mansion missions, and this one ranks up there with my favorites because the layout is so good. A wonderfully carved 3D space with lots of freedom. The decor is like a maximalist smorgasbord of Thiefy style and creative object use. I certainly ate my fill. But it's not just aesthetics, I thought the sneaking challenge setups were very good too. Just the right amount of noisy floors and carpet for my taste. I used my blackjack liberally for this one.
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OLG is actively involved in a watershed-scale planning and management initiative that not only fosters greater watershed stakeholder involvement, but also attempts to enhance the effectiveness of BMP implementation.
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WRAPS is funded using both EPA 319 and State of Kansas funds administered by the Kansas Department of Health and Environment.


There are many types of mental illness, so I will address the most common one – depression.
Unfortunately, very few herbs have been shown to be helpful in depression. St John's wort can have some efficacy at times but there are side effects that can be concerning. Beyond that, there are certainly a lot of nutritional supplements that can be helpful along with lifestyle change.


The parish council is aware that several streets on the Coopers Edge site have a poor broadband speed (less than 30 MBps). So we want to put pressure on Fastershire to include these streets in its plans to bring a super high speed fibre optic service to the majority of homes in the county.
· Go to Hucclecote Parish Council's Facebook page and add your name, house number, and street name.
· The more we get the better chance we have of getting Fastershire to do something – so tell you friends and neighbours and share this across any other social media that might help. And if you know of any lists/petitions or whatever that may already be circulating please take a photo of the list and post this to us via Facebook too.
· We need this information by close of play on 16 July.
The Parish will then write to the chief executive of Fastershire urging them to include all the homes on our list in its programme of works.
We may also ask everyone to send their own letters to them too (we'll provide a sample that you can adapt) . If Fastershire's post box is awash with letters from disgruntled residents it will add extra pressure.
POTENTIAL SOLUTIONS TO THE POOR BROADBAND ON COOPERS EDGE?


that will modify several aspects of the. It will also improve its performance and save you a lot of headaches caused by a wrong operation.
With this add-on you'll increase the game performance in a variety of aspects. First, you'll improve the graphics effects: lights, shadows, animations, effects and various other elements. This is possible because the patch modifies the code engines your hardware uses to process graphics. Thus, you'll get better defined graphics and have a better use of your PC's resources.
On the other hand, with this patch you'll solve the errors in Resident Evil 4 and, as a result, improve the game's stability. One of the most common problems solved with this application is the freezing that occurs when skipping the cinematic scenes seen during the game.
Finally, it´s important to mention that these and other modifications are fully compatible with the remainder of the game, so there is no reason to worry about any malfunction in another area. This is especially important for those who have already advanced a lot and are afraid to lose their saved progress. There is no reason to worry; this patch is fully compatible with the saving engine version 1.0.0.
The Resident Evil 4 patch is an improvement pack that will modify several aspects of the. It will also improve its performance and save you a lot of headaches caused by a wrong operation.


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The University of Notre Dame (ND.jobs) is accepting applications for a Graphic Designer - Grotto Network.
Applications will be accepted until 4/19/2019.
Grotto Network is a new digital media platform based at the University of Notre Dame that accompanies young adults, 18-34, who are marginally affiliated with the Catholic Church, but not particularly committed to a life of faith. We are gathering online and in-person communities to navigate life, make an impact, and keep the faith together.
Grotto's Graphic Designer will create and source inspirational and beautiful digital photographs, art, and graphics to attract, evangelize, and retain viewers.
The Graphic Designer is responsible for managing and further developing Grotto Network brand standards, including managing proper usage protocols for logos, colors, and fonts, through all departmental communication channels including broadcast, web, electronic media, etc. This position is responsible for graphic design of digital communication channels including newsletters, website, mobile apps, social media, digital advertising platforms, etc. This position requires outstanding creative abilities and the ability to effectively interface with Grotto staff as well as the University's Office of Public Affairs and Communication.
Bachelors degree; 4 years experience; proficiency in Adobe Photoshop, Illustrator, After Effects; knowledge and familiarity with the traditions and practices of the Catholic Church.
Please apply online at http://ND.jobs to Job # S19253. For additional information about working at the University of Notre Dame and various benefits available to employees, please visit http://hr.nd.edu/why-nd. The University of Notre Dame supports the needs of dual career couples and has a Dual Career Assistance Program in place to assist relocating spouses and significant others with their job search.


text:
Movie Review: 3:10 to Yuma (1957)
Synopsis: When a drought threatens to cost Dan Evans his ranch, he quickly agrees to accept $200 and escort captured outlaw Ben Wade to Contention City and put him on board the 3:10 train to Yuma. However, Wade's gang is determined to set their leader free and, with the town drunk being the only one willing to help, the odds of Dan completing his task alive are slim.
Who's in it? The movie stars Glenn Ford, Van Heflin, Felicia Farr, Henry Jones and Robert Emhardt.
Review: This film has been on one of our movie channels on multiple occasions but, every time I've attempted to watch it, I always managed to get interrupted and, because of that, never made it past the first few minutes.
I was, however, able to find the time to finally watch this film in its entirety this past weekend. Unfortunately, I don't think it was as enjoyable as I was expecting it to be.
Overall, I liked the plot of this film. Dan (Heflin) is a reluctant gunman who only takes the job escorting Ben Wade (Ford) because he needs the money. But, like all true western/cowboy heroes, he eventually becomes determined to finish his task even as the odds become increasingly stacked against him and the banker who hired him even offers to pay him the $200 to encourage him to walk away.
The problem I had with this film is it never really reached the potential I thought it had. One hero facing off against a small army of outlaws sounds exciting and, because of that, I was fully expecting this to be the traditional "shoot-'em-up western. Instead, the movie builds up a lot of hype but, ultimately, only a few shots were fired.
In fact, the movie seemed to be doing its best to avoid violence. Wade's gang had Dan seriously outnumbered and pinned inside a hotel. Yet, rather than simply rushing in, knowing he would never be able to take all of them, they chose to hang back. Not to mention, Dan's wife (Leora Dana) rode into town unmolested. You would think a gang of ruthless outlaws would have jumped at the chance to take her hostage and exchange her for their leader.
I also felt like the movie intended to give Wade more of a backstory than it did. There were plenty of clues indicating there was more to him than the film was showing but, at the same time, he seemed to lack any real depth for a main character.
This actually comes into play at the end of the movie too, with him inexplicably deciding to help Dan at the last second. In fact, without going into to much detail and giving spoilers, I kind of hated the ending, which had the two men seeming like they were suddenly friends or, at very least, on pleasant terms with each other. It honestly didn't make a whole lot of sense given the events (and speeches) leading up to it.
Final Opinion: When it was all said and done, I didn't hate the movie. But, I do think the 2007 remake was better.
My Grade: C
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text:
\section{INTRODUCTION}
The light-front wavefunction (LFWF) of the vector meson is an input in the QCD colour dipole model for calculating diffractive vector meson production.  In Ref. \cite{Forshaw:2012im}, successful predictions were obtained for diffractive $\rho$ production using a holographic wavefunction for the $\rho$ meson. The holographic meson wavefunction is predicted in holographic light-front  QCD proposed by Brodsky and de T\'eramond recently reviewed in \cite{Brodsky:2014yha}. In this work, we first use the new deep inelastic scattering (DIS) data from HERA collider, which were released in 2015 \cite{Abramowicz:2015mha}, to update the parameters of the color glass condensate (CGC) dipole model and then make predictions for diffractive $\phi$ meson production when a holographic LFWF is assumed for this vector meson.\cite{Ahmady:2016ujw}

\section{CGC DIPOLE MODEL}
In the dipole picture, the scattering amplitude for the diffractive process $\gamma^* p \to V p$ factorizes into an overlap of photon and vector meson light-front wavefunctions and a dipole cross-section \cite{Watt:2007nr}:
\begin{eqnarray}
\Im \mbox{m}\, \mathcal{A}_\lambda(s,t;Q^2)
  = \sum_{h, \bar{h}} \int {\mathrm d}^2 {\mathbf r} \; {\mathrm d} x \; \Psi^{\gamma^*,\lambda}_{h, \bar{h}}(r,x;Q^2)  \Psi^{V,\lambda}_{h, \bar{h}}(r,x)^* e^{-i x \mathrm{r} \cdot \mathbf{\Delta}} \mathcal{N}(x_{\text{m}},\mathrm{r}, \mathbf{\Delta})\; ,
\label{amplitude-VMP}
\end{eqnarray}
where $t=-\mathbf{\Delta}^2$ is the squared momentum transfer at the proton vertex. $\Psi^{\gamma^*,\lambda}_{h, \bar{h}}(r,x;Q^2)$ and $\Psi^{V,\lambda}_{h, \bar{h}}(r,x)$  are the light-front wavefunctions of photon and vector meson respectively while $\mathcal{N}(x_{\text{m}},\mathrm{r},\mathrm{\Delta})$ is the proton-dipole scattering amplitude. $h$ and $\bar{h}$ are the helicities of the quark and  the antiquark respectively. $r$ is the transverse size of the  color dipole and $x$ is the fraction of light-front momentum of the photon (or vector meson) carried by the quark. Both wavefunctions are labeled by $\lambda=L,T$ which denotes the polarization of the photon or vector meson. The photon light-front wavefunction is also a function  of the photon's virtuality $Q^2$. The dipole-proton  scattering amplitude  is the amplitude for the elastic scattering of the dipole on the proton and it depends on the photon-proton centre-of-mass energy $W$ via the modified Bjorken variable $x_{\mbox{\tiny m}}$ where
\begin{equation}
x_{\text{m}}=x_{\text{Bj}}\left(1+ \frac{M_V^2}{Q^2} \right)~\text{with}~x_{\text{Bj}}=\frac{Q^2}{W^2}
\;.
\label{Bjorken-x}
\end{equation}
The dipole-proton scattering amplitude is a universal object, appearing also in the formula for the fully inclusive DIS process: $\gamma^* p \to X$. In fact, by replacing the vector meson by a virtual photon in Equation \eqref{amplitude-VMP}, we obtain the amplitude for elastic Compton scattering $\gamma^* p \to \gamma^* p$, i.e.
\begin{eqnarray}
\left. \Im \mbox{m}\, \mathcal{A}_\lambda(s,t) \right|_{t=0}
&=&  s \sum_{h, \bar{h}} \int {\mathrm d}^2 {\mathbf r} \; {\mathrm d} x \; |\Psi^{\gamma^*,\lambda}_{h, \bar{h}}(r,x;Q^2)|^2  \hat{\sigma}(x_{\text{m}}, r) \; .
\label{amplitude-compton}
\end{eqnarray}
$\hat{\sigma}$ in Equation \eqref{amplitude-compton} is the dipole cross-section defined as follows:
\begin{equation}
\hat{\sigma}(x_{\text{m}},r)=\frac{\mathcal{N}(x_{\text{m}},\mathrm{r}, \mathbf{0})}  {s}=\int \mathrm d^2 \mathbf{b}~\mathcal{\tilde{N}}(x_{\text{m}},\mathrm{r}, \mathbf{b}) \;,
\label{dipole-xsec}
\end{equation}
where $\mathcal{\tilde{N}}$ is the Fourier transform of $\mathcal{{N}}$ in the $\mathbf{b}$ (impact parameter) space. Indeed, the elastic amplitude given by Equation \eqref{amplitude-compton} is directly related to the inclusive $\gamma^* p \to X$ total cross-section in DIS via the Optical Theorem:
\begin{equation}
\sigma_{\lambda}^{\gamma^* p \to X} = \sum_{h, \bar{h},f} \int {\mathrm d}^2 {\mathbf r} \; {\mathrm d} x \; |\Psi^{\gamma^*,\lambda}_{h, \bar{h}}(r,x;Q^2)|^2  \hat{\sigma}(x_{\text{m}}, r)\; ,
\label{gammapxsec}
\end{equation}
where now  \cite{Rezaeian:2013tka}
\begin{equation}
x_{\text{m}}=x_{\text{Bj}}\left(1+ \frac{4m_f^2}{Q^2} \right)~\text{with}~x_{\text{Bj}}=\frac{Q^2}{W^2}
\;.
\label{Bjorken-x-DIS}
\end{equation}

Therefore, one can use the high quality DIS data from HERA to constrain the free parameters of the dipole cross-section section and then use the same dipole cross-section to make predictions for vector meson production.

To lowest order in $\alpha_{\mbox{em}}$, the perturbative photon wavefunctions are given by \cite{Forshaw:2003ki}:
\begin{eqnarray} \Psi^{\gamma,L}_{h,\bar{h}}(r,x; Q^2, m_f)  &=& \sqrt{\frac{N_{c}}{4\pi}}\delta_{h,-\bar{h}}e\, e_{f}2 x(1-x) Q \frac{K_{0}(\epsilon r)}{2\pi}\;,
\label{photonwfL} \\
\Psi^{\gamma,T}_{h,\bar{h}}(r,x; Q^2, m_f) &=& \pm \sqrt{\frac{N_{c}}{2\pi}} e \, e_{f}
\big[i e^{ \pm i\theta_{r}} (x \delta_{h\pm,\bar{h}\mp} -  (1-x) \delta_{h\mp,\bar{h}\pm}) \partial_{r}   +  m_{f} \delta_{h\pm,\bar{h}\pm} \big]\frac{K_{0}(\epsilon r)}{2\pi}\; , \label{photonwfT}
\end{eqnarray}
where
$ \epsilon^{2} = x(1-x)Q^{2} + m_{f}^{2} $ and $r e^{i \theta_{r}}$ is the complex notation for the transverse separation between the quark and anti-quark. As is evident from Equation \eqref{photonwfT}, at $Q^2 \to 0$ or $x \to (0,1)$, the photon light-front wavefunctions become sensitive to the non-zero quark mass $m_f$ which prevents the modified Bessel function $K_0(\epsilon r)$ from diverging, i.e. the quark mass acts as an infrared regulator. On the other hand, a non-perturbative model  for the meson light-front wavefunction is used and assumed to be valid for all $r$.

A simple model for the $b$-integrated dipole-proton amplitude, i.e. the dipole cross-section in Equation \eqref{dipole-xsec} has been proposed in Ref. \cite{Iancu:2003ge}. This is known as the CGC dipole model and is given by
\begin{equation}
\hat{\sigma}(x_{\text{m}},r) = \sigma_0 \, {{ \mathcal N } (x_{\text{m}}, r Q_s, 0 ) }\; ,
\end{equation}
with \begin{eqnarray}
{ \mathcal N } (x_{\text{m}},r Q_s, 0) &=& { \mathcal N}_0 \left ( { r Q_s \over 2 }\right)^ {2 \left [ \gamma_s + { {\mathrm ln}  (2 / r Q_s) \over  \kappa \, \lambda \, {\mathrm ln} (1/x_{\text{m}}) }\right]}  ~~~~~~~{\rm for } ~~~~~ ~~~~ r Q_s \leq 2 \nonumber \\
&=& { 1- \exp[-{\mathcal A} \,{\mathrm ln}^2 ( {\mathcal B} \, r Q_s)]}  ~~~~~~~~~{\rm for } ~~~~~ ~~~~ r Q_s > 2 \; ,
\end{eqnarray}
where the saturation scale $Q_s = (x_0/x_{\text{m}})^{\lambda / 2}$ GeV. The coefficients ${\mathcal A}$  and ${\mathcal B}$ are determined  from the condition that the ${\mathcal N}(r Q_s, x)$ and its derivative with respect to $r Q_s$ are  continuous at $r Q_s=2$.  This leads to
\begin{equation}  {\mathcal A} =  - { ({ \mathcal N}_0 \gamma_s)^2  \over (1 - { \mathcal N}_0)^2 \, {\mathrm ln}[1 - { \mathcal N}_0] }\,, ~~~~~~
{\mathcal B} = {1 \over 2} (1 - { \mathcal N}_0)^{-{(1 - { \mathcal N}_0) \over { \mathcal N}_0 \gamma_s }}\,.
\end{equation}
The free parameters of the CGC dipole model are $\sigma_0, \lambda, x_0$ and $\gamma_s$ which are fixed by a fit to the structure function $F_2$ data.  In 2015, the H1 and ZEUS collaborations have released highly precise combined data sets \cite{Abramowicz:2015mha} for the reduced cross-section
\begin{equation}
\sigma_r(Q^2,x,y)=F_2(Q^2,x)-\frac{y^2}{1+(1-y)^2} F_L(Q^2,x) \; ,
\label{sigmar}
\end{equation}
where $y=Q^2/\hat{s}x$ and $\sqrt{\hat{s}}$ is the centre of mass energy of the $e p$ system for $4$ different bins : $\sqrt{\hat{s}}=225$ GeV ($78$ data points),  $\sqrt{\hat{s}}=251$ GeV ($118$ data points) and $\sqrt{\hat{s}}=300$ GeV ($71$ data points), $\sqrt{\hat{s}}=318$ GeV ($245$ data points).  Our fitted values for the CGC dipole model parameters  together with the resulting  $\chi^2$ per degrees of freedom ($\chi^2/\mbox{d.o.f}$) values are shown in Table \ref{tab:F2fit}. The first two rows indicate that the fit is not very sensitive to the variation in the strange quark mass. Comparing the second and third rows, we can see that the data prefer the lower $u$ and $d$ quark masses and that increasing them give quite different fit parameters especially for $x_0$.

\begin{table}[h]
	\caption{Parameters of the CGC dipole model extracted from our fits to inclusive DIS data (with $x_{\text{Bj}} \le 0.01$ and $Q^2\in [0.045, 45]\,\text{GeV}^2$) using $3$ different sets of quark masses.}
	\label{tab:F2fit}
	\tabcolsep7pt
	\begin{tabular}{lcccccc}
		\hline
		 \tch{1}{c}{b}{$[m_{u,d},m_s]$/GeV}  & \tch{1}{c}{b}{$\gamma_s$} & \tch{1}{c}{b}{$\sigma_0$/mb}  & \tch{1}{c}{b}{$x_0$}  & \tch{1}{c}{b}{$\lambda$} & \tch{1}{c}{b}{$\chi^2/\mbox{d.o.f}$}  \\
		\hline
			$ [0.046,0.357]$ & $0.741$  &  $26.3$ & $1.81 \times 10^{-5}$ & $0.219$ & 535/520=1.03\\
			$ [0.046,0.14]$ & $0.722$  &  $24.9$ & $1.80 \times 10^{-5}$ & $0.222$ & 529/520=1.02\\
			$ [0.14,0.14]$ & $0.724$  &  $29.9$ & $6.33 \times 10^{-6}$ & $0.206$ & 554/520=1.07\\
		\hline
	\end{tabular}
\end{table}

\section{HOLOGRAPHIC MESON LFWF}
\label{Holographic wfn}
The vector meson light-front wavefunctions appearing in Equation \eqref{amplitude-VMP} cannot be computed in perturbation theory. Explicitly, the vector meson light-front wavefunctions can be written as \cite{Forshaw:2012im}
\begin{equation}
\Psi^{V,L}_{h,\bar{h}}(r,x) =  \frac{1}{2} \delta_{h,-\bar{h}}  \bigg[ 1 +
{ m_{f}^{2} -  \nabla_r^{2}  \over x(1-x)M^2_{V} } \bigg] \Psi_L(r,x)
\label{mesonL}
\end{equation}
and
\begin{equation} \Psi^{V, T}_{h,\bar{h}}(r,x) = \pm \bigg[  i e^{\pm i\theta_{r}}  ( x \delta_{h\pm,\bar{h}\mp} - (1-x)  \delta_{h\mp,\bar{h}\pm})  \partial_{r}+ m_{f}\delta_{h\pm,\bar{h}\pm} \bigg] {\Psi_T(r,x) \over 2 x (1-x)}\,.
\label{mesonT}
\end{equation}

Various ansatz for the non-perturbative meson wavefunction have been proposed in the literature, but in recent years, new insights about hadronic light-front wavefunctions based on the anti-de Sitter/Conformal Field Theory (AdS/CFT) correspondence have been proposed by Brodsky and de T\'eramond. \cite{Brodsky:2014yha}. In this framework the vector meson wavefunctions $\Psi_\lambda(r,x),\; \lambda=T,\; L$ are given as
\begin{equation}  \Psi_{\lambda} (x,\zeta) = \mathcal{N}_{\lambda} \sqrt{x (1-x)}  \exp{ \left[ -{ \kappa^2 \zeta^2  \over 2} \right] }
\exp{ \left[ -{m_f^2 \over 2 \kappa^2 x(1-x) } \right]} \; ,
\label{hwf}
\end{equation}
where we have introduced a polarization-dependent normalization constant ${\mathcal N}_{\lambda}$. We fix this normalization constant by requiring that
\begin{equation}
\sum_{h,\bar{h}} \int {\mathrm d}^2 {\mathbf{r}} \, {\mathrm d} x |
\Psi^{V, \lambda} _{h, {\bar h}}(x, r)|^{2} = 1 \; ,
\end{equation}
where $\Psi^{V,\lambda}_{h, \bar {h}}(x,r)$ are given by Equations \eqref{mesonL} and \eqref{mesonT}.

\section{COMPARISON WITH DATA}
Having specified the dipole cross-section and the holographic meson wavefunction, we can now compute cross-section for diffractive $\phi$ production.  We shall show predictions using three sets of the CGC dipole parameters as given in Table \ref{tab:F2fit}. We shall refer to these three sets of predictions as Fit A (first row), Fit B (second row) and Fit C (third row) respectively. Recall that all our predictions will be generated using the same holographic wavefunction given by Equation \eqref{hwf} and they differ only by the choice of quark masses and the corresponding fitted parameters of the CGC dipole model as given in Table \ref{tab:F2fit}.

For $\phi$ production, our predictions for the $Q^2$ dependence of the total cross-section at fixed $W$ are shown in Figure~\ref{phi-q2}. Here, it is clear that the Fit A predictions (solid black curves) are not successful. The data prefer slightly the Fit B (orange dotted curves) over the Fit C predictions (blue dashed curves) although the lack of data in the low $Q^2$ region prevents us from making a definite statement. At high $Q^2$, our predictions tend to undershoot the (ZEUS) data as expected. Our predictions for the longitudinal to transverse cross-sections ratio for $\phi$ production are shown in Figure~\ref{phi-q2}. We can see that the ratio data tend to favour the Fit A  prediction (solid black curve) although they are not precise enough to discard the other two predictions.

\begin{figure}
	\centerline {%
		\includegraphics
		[width =.55\textwidth ]{phi_q2.pdf}\hskip -0.75cm\includegraphics[width=.55\textwidth]{phi_R.pdf}}
	\caption{Predictions for the $\phi$ production total cross section (left) and longitudinal to transverse cross-section ratio (right) at $W=90$ GeV as a function of $Q^2$  compared to HERA data \cite{Chekanov:2005cqa,Aaron:2009xp}. Black solid curve: A. Orange dotted curve: B. Blue dashed curve: C.}
	\label{phi-q2}
	\end{figure}
\section{ACKNOWLEDGMENTS}
This research is supported by a Team Discovery Grant from the Natural Sciences and Engineering Research Council (NSERC) of Canada.

\bibliographystyle{aipnum-cp}%

redpajama_set_name: RedPajamaArXiv


text:
[The Lady of the Lakes]: A Review
On February 12, 2018 By Jane @ Greenish BookshelfIn 2018, Review
Happy Monday, everyone!
It's been chilly here which had me wishing I could just read all day. I've finally been getting into Moon Over Manifest by Clare Vanderpool. As always, I'm playing catch up with my reviews. Really excited to review The Lady of the Lakes by Josi S. Kilpack.
I have officially read all three of Kilpack's historical proper romances now. (Check out my first review here.) I love the focus on literary historical figures!
"You have a romantic soul, Walter."
The Lady of the Lakes, page 118
I am feeling inspired to read more by the authors that she develops in these love stories including Sir Walter Scott. He is a fascinating individual with a deep love and connection with his homeland of Scotland. His diligence and hard work propel him to the voice of Scottish literature. I would like to read more of his novels, especially Waverly, and his poetry.
Initial Thoughts:
This is my favorite historical proper romance from Kilpack! The characters are gorgeous and I love the complexity of the story.
I have some experience reading Sir Walter Scott in graduate school. I read his The Heart of Midlothian and some of his poetry for a class on the 19th century bestseller. It was a fascinating class. And I loved Scott's novel especially. I'd like to read more of his novels! I've also seen the Heart of Midlothian mosaic in Edinburgh while on study abroad.
There are several spoiler allusions in my review. A few more thoughts on historical romances below.
The Lady of the Lakes by Josi S. Kilpack tells the story of Sir Walter Scott as he falls in love and seeks his place in the Scottish literary canon. Goodreads summarizes, "Walter Scott has three passions: Scotland, poetry, and Mina Stuart. Though she is young and they are from different stations in society, Walter is certain their love is meant to be. For years, he has courted her through love letters. She is the sunshine of his soul. . . . At twenty-six, Charlotte Carpenter believes she will never find love. After all, she is a Catholic-born Frenchwoman living in London with a family history shadowed by scandal. Though quiet, practical, and determined to live a life of independence, her heart longs for someone to love her and a place to call home. Passion and promises collide as Walter, Mina, and Charlotte must each decide the course for their futures. What are they each willing to risk to find love and be loved in return?"
For me, this is a novel that I could guess the end from the beginning. Most historical romances are like that. You usually hope for a beautiful happily ever after. What I love about historical romances is the journey. You know the ending. But you don't know how the characters will get there. This novel offers a beautiful, complex journey to a very satisfying happily ever after.
I really enjoyed the journey that Walter goes through during this novel. He begins the novel naive and romantic. He believes he has found his true love and refuses to see any other option. At first, he was annoying in his stubbornness. I didn't see the deep connections he did with Mina. But I appreciated what happens in his character as the novel continued. At first he mourned deeply for his personal loss, but then he found a way to move forward. And I love the beautiful love he finds in the end.
"'You don't believe in love at first sight?'. . . 'You can only love someone when you know them and that takes time and attention'."
"God can move mountains to see His work done, my child, and it serves us well not to critique Him too harshly for His methods, but to try to appreciate the views He blesses us to see."
"I think that a marriage must start with love that can grow. To start with respect seems as though you would grow respect. Regard will grow regard."
The Lady of the Lakes, pages 197, 252 & 281
Of the love interests in this novel, Charlotte was the most intriguing and complex. Her character was so interesting because she was unique. Her background is unconventional and her desires for independence are less common for the time. I love the way she is able to be herself, especially with Walter. Her realistic, blunt nature is a beautiful balance for his romantic sensibilities. She doesn't expect to find love or a family in her life, which makes it all the more beautiful when she does.
I love novels with multiple perspectives and plot–and this is no exception. We start with several stories that seem separate. Charlotte is in London, Walter in Edinburgh, and Mina at her family's estate in Scotland. Kilpack creates beautiful intersections between these stories. The characters interact and change because of their interactions. I especially love the redemption and healing that Walter experiences when his path finally crosses with Charlotte.
"You are my future, my heart, my hope, my everything. Marry me, . . . Be my wife and let us make a beautiful life together."
"In every aspect of my life she made me better–she made me whole–and I had watched her grow and blossom in the same way."
The Lady of the Lakes, pages 297 & 307
Every good love story needs a beautiful romantic kiss. The best love stories create a tension that pulls readers along waiting for that moment. I also appreciate romances like this one that are clean. I appreciate that there is literature that celebrates love without inappropriate details.We get a gorgeous story about love–in a pure and positive light. I love that. I love the build up to the passionate, emotional kiss that the lovers share towards the end of this novel.
This story weaves a beautiful tapestry of what it means to love, to heal, and to grow. The emotions are strong. The strength is inspiring. The love story is timeless. If you're new to historical romance or if you're a veteran, you'll love The Lady of the Lakes.
What are some of your favorite historical romances?
Have you read anything by Sir Walter Scott?
favoritesgreat character developmentgreat storytellinghistorical fictionhistorical romancelove story
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