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Home › Online Documentation (2.2) › Introduction › Common Screens ›
All the Write Email screens look like the following:
(1) At the top there are a set of buttons:
Send - sends the email
Template - fills the email subject and text with content from a template
Attach - allows you to attach a relevant document (a select window will open allowing you to find the required document from those belonging to the current customer/supplier/etc)
Attach File - allows you attach any file (a browse window will open allowing you to select any file on your computer)
Cancel - cancels the write email operation
(2) the From/To/CC/BCC/Subject block:
From - will display the preferred email address for the current Practice Location, but if you have multiple email addresses defined, then you can use the pull-down to select another. For example:
Note that in the pull-down, the name of the Practice Location is shown in brackets - but this is removed when the address is selected.
You cannot enter an arbitary From email address - you must use one of the practice location's email addresses selected from the pull-down.
To/CC/BCC - you can either use the pull-downs to select an address, or enter addresses directly.
If you use the pull-downs then the selected address in the pull-down will replace any existing address(es). All relevant addresses will be shown. For example:
In the above case, the email was invoked from the Patient screen and hence includes the referring vet addresses. If this was invoked from the Customer screen, then the vets would not be shown. So use the pull-downs for quick and easy selection of the relevant addresses.
Note that in the pull-down, the name of the entity is shown in brackets so that you can see where the address is coming from. Hence the 2nd line shows Bill Bourke, but we know that this must be an email address listed for the customer Bourke,Johanna. Again, the name in brackets is not included when the line is selected from the pull-down. The last two lines appear as shown because the veteast.com.au email contact has the email name 'Email Address', whereas the veteast[at]gmail[dot]com contact has the email name 'Veteast'.
For more flexibility, you can also either enter an email address (eg bloggs[at]gmail[dot]com) or enter all or part of a name (eg bloggs,fred or bloggs, or blo, or %,fred) and then press the Enter key. If there is a single match this will be filled in. Otherwise the Address Book screen will be displayed showing the matches. Note that as indicated by the last example, you can use % as a wildcard; %,fred will find all who have Fred (or Frederick) as a first name, whereas %fred would also find names (like Alfred,John) containing 'fred'. If you press the Enter key with the cursor positioned on an empty line, the Address Book will open showing all email addresses in the system.
You can use multiple addressees separated by semi-colons (;).
You must have at least one To addressee, the CC and BCC addressees are optional.
Subject - enter an appropriate subject. Note that this is a mandatory field.
(3) the Text area - enter the text of the email. To enter macros, use:
Ctrl-M to insert the text of a macro (assuming you know its code)
Alt-M to display available macros, and insert the text of the selected macro
Note that the text coming in from the macro expansion retains its formatting so that long lines will not be wrapped at the margin, and any spaces at the start of the line(s) or within the line(s) will be retained. Thus columns and indents are preserved.
(4) the formatting controls - each of the icons has a top tip, so hovering the mouse over an icon will tell you what it does. The three boxes with pull-downs above the icons allow you to select the style, font and size respectively.
(5) the attachments area - as you add documents and files, they will be shown here. Note that if you want to delete one on them, click on the attachment to select it and then press the Delete key. Actually it's a little more tricky than this. When the item is first attached it looks 'white' like the following: . If you click it in the middle (or anywhere except the icon at the left end), then the attachment becomes selected and the background goes cream like: . You can now press delete to delete it.
If you click on the icon at the left end, then the item will be downloaded to your browser (and displayed if possible).
Below is an example of the Address Book screen. The user has entered just 'sm' as the email address - the system checked and found more than one matching name and displayed them
Click on the required line to select the addressee. Alternatively enter a new search string and press Find.
If the Type is left at the default 'All', the address book shows all types. You can use the pull-down to select just say Users (if you were looking for a staff member).
Note that the search is done on the name of the contact, not the email address or the email address name.
If the contact has an email address name, then this will be shown in brackets. In the above, all the matching contacts have an email address name except the Supplier(Person) on the second line. We can also see that Mrs Kay Smith is in fact a second email contact for the customer Smith,Michael. Note that the user SM has been included because his user name is SM, although he is Dr Sam Michaels.
The Template button displays a list of the available templates that may be used to fill emails with content.
If a template has parameters, these will be prompted for.
‹ Edit up Attach Document ›


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2. Practice\Principle of Precautions in Attack
Nigeria (current)
Practice Relating to Rule 15. The Principle of Precautions in Attack
Section A. Constant care to spare the civilian population, civilians and civilian objects
Nigeria's Military Manual (1994) lists as one of the basic principles in the conduct of operations, every commander's duty "to spare the civilian population, civilian persons and civilian objects". The manual adds: "When planning action that could endanger civilian persons and objects therefore, care and precaution must be emphasised and exercised in the conduct of the war."
Nigeria, International Humanitarian Law (IHL), Directorate of Legal Services, Nigerian Army, 1994, p. 42, § 11.
Nigeria's Military Manual (1994) and Soldiers' Code of Conduct state: "Civilian persons and objects must be spared."
Nigeria, International Humanitarian Law (IHL), Directorate of Legal Services, Nigerian Army, 1994, p. 39, § 5(c); Code of Conduct for Combatants, "The Soldier's Rules", Nigerian Army, undated, § 3.
Section B. Avoidance or minimization of incidental damage
Nigeria's Military Manual (1994) states: "Precaution shall be taken to minimise civilian casualties and damage."
Nigeria, International Humanitarian Law (IHL), Directorate of Legal Services, Nigerian Army, 1994, p. 45, § 16(b).
Section D. Information required for deciding upon precautions in attack
Nigeria's Military Manual (1994) provides: "The commander, through his intelligence network shall get information on the circumstance of the military relevancy of the zone, specifically protected zones or objects in his area of operations."

redpajama_set_name: RedPajamaCommonCrawl


Cubus Leather Bag is a bag with a removable shoulder strap that can be worn in different ways. It has zip closure and external zip pocket. It is made of 100% vegetable tanned leather. This bag can be completely folded in a flat regenerated-leather packaging.


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Order Name Tags/Plates
About UsTFM2020-12-08T01:31:29-05:00
ASAP Identification Security, Inc., has been helping businesses, schools and corporations for almost
30 years. Located in the heart of the crossroads of America, ASAP is now a top vendor for many
of Indiana's largest employers! ASAP is proud to be a woman-owned business.
WBE Certified: City of Indianapolis, State of Indiana, WBENC
WOSB Certified
About SheilaTFM2020-12-08T01:14:22-05:00
About Sheila
Sheila grew up in Indianapolis and attended college in Ohio.
Like many mid-west college grads in the early 90s, she was drawn to the Windy City immediately following college where she lived and worked for Andersen Consulting and was assigned to clients ranging from manufacturing to service to retail. With that knowledge, she applied to and was accepted at Indiana University (Kelley) School of Business where she earned her MBA in Operations Management.
With her newfound degree, Sheila was recruited by Hewlett Packard/Agilent to lead a global team to identify opportunities for efficiency improvements throughout the supply chain and then work to establish and optimize distribution centers in the US, Europa and Asia. The years at HP/Agilent were fantastic and enabled her to travel extensively and work with colleagues from all corners of the world.
Post HP/Agilent, Sheila and her husband and children decided living/working closer to home was her next calling so it was then that she took over her father's small photo ID business in Indianapolis and she has worked to expand and grow to be a top vendor for many of Indiana's largest employers. She is well on her way!
About TomTFM2021-02-24T13:43:44-05:00
March 5, 1934 – February 12, 2021
Tom was born and raised in Delaware where he attended Archmere Academy and University of Delaware (Fighting Blue Hens) where he earned a BA in History and Social Studies. Upon completion of his degree, he joined the US Navy, became a commissioned Salvage and Diving Officer and a served on the USS Current.
Following his time in the US Navy, Tom met and married his best friend, Mary Ellen in 1959 and shortly thereafter they started a family. In 1964, Tom earned his Masters in Social Science Education and worked in the Delaware Public Schools and in 1968 he moved his wife and 6 children on a grand adventure from Delaware to Indiana in order for Tom to complete his Masters in Economics Education at Purdue University. In 1970 the family (now 7 children) moved to Bloomington, IN for Tom to pursue his Doctorate from Indiana University.
For the family, there was 1 more child and 1 more move in the future. In 1973, Tom was recruited as a teacher and the principal of a high school in Indianapolis. The family of 10 + trusty dog, Pete, moved to their new home in August 1973 to start a new adventure.
After 10 years of school administration, Tom accepted a position with the US Army as a Supervisory Instructional Systems Specialist, but his entrepreneurial spirit was beginning to take hold and he started ASAP Identification in the basement (no, not the HP garage) of his family home while still working for the US Army. In 1994 he moved into an office space in downtown Indianapolis and quit his job at the US Army to pursue ASAP full time. In 2006 he was joined by his daughter, Sheila.
Tom is now retired. He is a prostate cancer and melanoma survivor and now is fighting early dementia. Fortunately for his family, his dementia has left him only with some memory issues but he is still the lovable, happy and optimistic Tommy that we all have gotten to know over the years. He is cared for by his loving wife and his community. While we hope and pray for a cure for this devastating disease, we hold onto all the loving memories that no one can take from us!
Ready to order? Let's get started!
ASAP Identification Security, Inc.
info@asapident.com
2020 © Copyright ASAP Identification Security, Inc


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Q: Can I center a UIToolbar item? I am putting a label on a UIToolbar (per this tip: Adding a UILabel to a UIToolbar).
But the toolbar has a button on the left side, and so flexible spaces throw the label off the center, which is where I'd like it to be. Can I somehow center this toolbar item so that it remains centered in the toolbar?
(Already tried balancing the button with a dummy fixed space, no dice.)
Thanks!

A: To center a text/title on a toolbar you can use a simple UILabel like see below:
UILabel *labelTitle = [[UILabel alloc] init];
labelTitle.font =[UIFont fontWithName:@"Helvetica-Bold" size:18];
labelTitle.backgroundColor = [UIColor clearColor];
labelTitle.textAlignment = UITextAlignmentCenter;
labelTitle.userInteractionEnabled = NO;
labelTitle.text = @"Your Title";
[labelTitle sizeToFit];
CGRect labelTitleFrame = labelTitle.frame;
labelTitleFrame.size.width = self.toolbar.bounds.size.width;
labelTitleFrame.origin.y = (self.toolbar.bounds.size.height - labelTitleFrame.size.height) / 2;
labelTitle.frame = labelTitleFrame;
labelTitle.autoresizingMask = UIViewAutoresizingFlexibleWidth;
// Just add UILabel like UIToolBar's subview
[self.toolbar addSubview:labelTitle];
[labelTitle release];
labelTitle = nil;

A: Simplest way would be to put the label above the bar, in it's parent view, and justify it there.

A: Add a flexible space item to the left and right of your center item, like you did. Then add a fixed space item at the end and set the width to whatever the left button width is -- somewhere around 28 pixels.
UIBarButtonItem *fixedItem = [[[UIBarButtonItem alloc] initWithBarButtonSystemItem:UIBarButtonSystemItemFixedSpace target:nil action:NULL] autorelease];
fixedItem.width = 28;

A: Yes we can center a toolbar item just put two flexible space in the toolbar like :
UIBarButtonItem *flexibaleSpaceBarButton = [[UIBarButtonItem alloc] initWithBarButtonSystemItem:UIBarButtonSystemItemFlexibleSpace target:nil action:nil];

toolbar.items = [NSArray arrayWithObjects:loginButton,flexibaleSpaceBarButton,toolBarLabel,flexibaleSpaceBarButton, nil];

A: If you DON'T use flexible or fixed spaces, you can modify the internal UIToolbar UIStackView distribution as below. Note that you should call toolbar.centerItemsHorizontally() in your view controller's viewDidLayoutSubviews() method.
extension UIView {
    func allSubviews() -> [UIView] {
        var _allSubviews: [UIView] = []
        for subview in self.subviews {
            _allSubviews += subview.allSubviews()
            _allSubviews.append(subview)
        }
        return _allSubviews
    }
}
extension UIToolbar {
    func centerItemsHorizontally() {
        allSubviews().forEach { subview in
            if let stackView = subview as? UIStackView {
                stackView.distribution = .fillEqually
            }
        }
    }
}

Result:

redpajama_set_name: RedPajamaStackExchange


An electrical appliance, a humidifier is a device that works to increase moisture in a room or in a whole building. While at home humidifiers work to increase moisture in a particular room, whole house whole house or even furnace humidifiers furnace humidifiers link up to the HVAC of a home so that the entire home has sufficient moisture.
How does an impeller humidifier work?
A cool mist humidifier or an impeller humidifier works by using a rotating disc to spin water at a diffuser. This breaks up the water into tiny droplets that fill the air. The water supply should be extremely clean or bacteria or mould could develop in the air.
They are usually table top units, with a capacity ranging between 9 litres and 13 litres of water, which is filled manually. Being table top devices, they are portable too.
The build-up of minerals such as calcium and magnesium in the water usually leads to lung and other problems, including asthma and skin cracks and bleeding. This happens when you don't clean your humidifier often enough. However, in the case of impeller humidifiers, the metal deposits in the water are ejected into the air, thereby the problem of white dust is negated here.
Besides, impeller humidifiers use electricity to And unlike steam humidifiers, cool-mist units use electricity only to give a boost to the air, rather than providing any heat. Consequently, they do not use much electricity. However, on the flip side, impeller humidifiers are noisy.
Reviews: The market is rife with cool mist impeller humidifiers. In such a scenario, how do you choose the one you should have? We have taken the headache out of your decision-making by shortlisting the five best impeller humidifiers available today.
Read their features and decide the one you want from them.
This impeller humidifier doesn't just stand out for sleek design and compact nature. It actually works hard to enhance indoor air quality and protect you and your family from the ill-effects of harsh and dry air during winters.
The device is especially treated with antimicrobials so that no bacteria grows and malodours disappear. When in use, it produces a refreshing cool spray that can fight symptoms of cough and cold. Its patented impeller disk stops mist from being ejected out of the device.
Its run time is 28 hours and does this on one filling. Its tank capacity is 4.5 litres and the fact that its output is 3.8 litres makes it ideal for small rooms. New users of this product should take note of the fact that it may make a vibrating noise if the motor assembly isn't set right.
Indoor air is stripped of its natural humidity thanks to the heating systems and air conditioners used in homes in winter and summer respectively. Humidifiers help our respiratory organs keep to the normal humidity levels while also relieving us of cough and cold, irritation in the eyes and itchy skin.
The Kaz Health Mist Quiet Operation Cool Mist Humidifier has a pick-up tube through which water is drawn by electricity. From here, it is motor pushed using centrifugal force to give a fine mist which is released in the room.
While this happens, this humidifier also works to filter the ambient air of dust, odours, pollen and tobacco smoke, thereby removing a minimum of 93% of particles as minute as pollen.
It works smoothly, efficiently and quietly.
This one is a second generation humidifier that works far more silently than its predecessors. That's because its inner construction works to reduce any noise that blows through the air pipe. The ultrasonic technology that governs its construction works to lower the noise level to about 32dB so that humidification takes place silently. This keeps your baby undisturbed while you can work or study too.
Its set-up is easy to follow and the one-touch mechanism makes everything easy to do. Its two-litre water tank can spray mist all night while its capacity is barely 1.9 litres. In low mist, it can spray up to 10 hours.
It can work efficiently to cover an area of 200 square feet of office rooms, bedrooms or any other rooms. With high-frequency ultrasonic oscillation technology, this model helps atomize water into fine spray. Besides, the dim night light helps you sleep in a relaxed fashion.
When the water level is very low or the water tank has been removed, the humidifier will automatically switch off. This is a great help when you leave home in a hurry and forget to switch it off manually.
This humidifier comes with two mist setting levels—high and low—so that you can easily adjust the direction of the mist and speed for your greater comfort. A one-touch button does it all for you.
The Cool Mist Humidifier does not require a filter and is therefore economical. Further, it is covered with a replacement warranty for one year and customers also get a 60 days money back guarantee. Customers can also avail of easy to procure and follow-up services in cases of need.
Silent, effective and extremely dependable, the Honeywell HCM-350 is also affordable. It has all the essential features that a good unit would need for a home environment. This humidifier is an evaporative one, which works by adding moisture to the dry environment with the use of a fan, wick and reservoir that contain water.
This device is designed to work over an area of 500 sq. ft. It uses about 3.5 litres of water every 24 hours on low, making it ideal for medium-sized rooms and bedrooms. With the help of UV technology, it can kill 99.9% of fungi and bacteria present in the water. It can get rid of dry skin, cough and allergies.
Though evaporative technology is indeed very effective, yet it has its limitations. For instance, you cannot over-humidify a room with this technology because it's impossible to increase humidity levels in the air more than its capacity.
With humidity levels in homes not exceeding an average of 50%, the ambient air can make one feel warm and help them breathe and sleep better, and be relieved of dry skin and nasal congestion, apart from static electricity and skin irritation. Furniture can also be saved from damage.
This mini filter, made with advanced technology, fortunately doesn't need any filters to be replaced, yet its 1.9 litre water tank can keep users moisturized for a maximum of 20 hours. Imagine being sprayed with cooling mist for this entire period!
This small-sized humidifier works quietly and efficiently, and is ideal for a small bedroom or your child's nursery. If the air in your home is dry, or it's allergy season or one is sick, using a humidifier can be a great asset as it cools the air with its moisture content.
If a child has cough or nasal congestion, a humidifier in the bedroom can help him sleep at night undisturbed. Though this is only temporary relief, yet his sleep will not be interrupted with coughing fits and he will be able to breathe better.
No matter where an individual may be—at home or at work—having a humidifier always helps him or her breathe better.
For all the many virtues of an impeller or cool mist humidifier, it is well worth considering making an investment in this device. Besides, they are easily available and are made by leading manufacturers in this space.


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By Brown on	 December 31, 2021 Novelist
Won't author JK Rowling be part of the Harry Potter 20th anniversary reunion? (Photo credit – Facebook; Poster)
Harry Potter's 20th Anniversary: Return to Hogwarts is set to release on Amazon Prime tomorrow (January 1) and fans can't help but go wild with excitement. From Daniel Radcliffe to Tom Felton, all of Potter's fame will adorn this special reunion. However, the fandom is now confused whether Harry Potter author JK Rowling herself will attend the reunion or not.
Read on to find out if the author would join the HP cast for the reunion or not.
The answer to Harry Potter's Fandom question is an emphatic no. Author JK Rowling will not be part of the 20th Anniversary of Harry Potter: Return to Hogwarts. Yes, you read that right.
We're not saying it, but according to Entertainment Weekly, author JK Rowling was indeed invited for Harry Potter 20th Anniversary: Returns To Hogwarts (reunion). However, the author herself chose not to attend.
According to reports, it is said that the author's team "have determined that the writer's archived comments are adequate." Reports further state that "Rowling's statements about trans people and the controversy surrounding them did not play a role in the team's decision."
Rowling's absence from the special reunion was indeed a surprise. Many of them assumed it was HBO Max and Warner Bros. who didn't want her to attend the reunion in order to avoid backlash due to her insensitive transphobic comments. However, it now seems that things are clear now.
For the uninformed, JK Rowling has been on the radar of the masses for her transphobic tweets and statements she made amid the pandemic. The author was recently seen making headlines for the same thing, as she recently slammed a portal for their poll on her, titled "Only Two Genres." The Harry Potter novelist accused the portal of misquoting her statements.
In the meantime, are you excited to see Harry Potter 20th Anniversary: Returns To Hogwarts? Let us know your thoughts in the comments below!
For more amazing updates follow Koimoi
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Review of the cultural year 2021 – Lily Lindon: meet the editor and novelist who has herself doubled her outfit
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Irregular verbs, dialects, and sockpuppets
I have a few new posts up at Macmillan Dictionary Blog. First up, Irregular ours considers irregular verbs, whose familiarity obscures their peculiarity – most pronounced in everyday words like be and go:
Irregular verbs can be awkward items for students, requiring to be learned (or learnt) by heart rather than by a simple rule. But they are also historical artefacts that have stubbornly withstood (not withstanded) the pressure to conform, and they shed light on the shapes and structure of English morphology – word formation – as it has unfolded over the centuries.
The post also looks at how new irregulars (snuck, knelt) sometimes appear; how old ones (holp, brung) survive in regional dialects; and how irregular forms, far from being chaotic, tend to follow patterns and sub-rules of their own.
Dialects in dialogue continues the theme, briefly discussing regional variation, how conformity squeezed it out of the emerging standard variety of English, and how authors continued to convey it through the technique of 'eye dialect':
Variation in language goes beyond inflection and vocabulary, of course. In everyday encounters it is most noticeable in our accents. As children we learn sounds from the people around us, typically our families, neighbours and peers, and we imbue our accent with qualities all our own. The signature sound of our voice is the result of a unique anatomy, personality, and social environment. . . .
Spelling became largely standardised as Middle English developed gradually into Early Modern English. But authors continued to exploit the features of regional speech, which retained – and still retains – old grammatical and phonetic variants. [read more]
Finally, On the metaphor of sock puppets addresses the term sock puppet in its new online incarnation. Describing it as "the use of a fake identity online for the purposes of talking about oneself, typically in a self-promoting way", I examine the term's connotations and appropriateness, especially in light of the etymology of puppet and the other metaphorical uses to which it is put:
The fun and friendly feel of sock puppets, perhaps helped by puppet's similarity to poppet and indeed puppy, seems awkwardly at odds with the sneaky behaviour it has come to mean. At first glance the term doesn't fit well with the usual metaphors of deception, which evoke things that are dark, down, dirty and hidden – not playful and brightly coloured. But when we look at puppet's other metaphorical uses, we see it's not such a leap. [read more]
Older posts are available in my archive at Macmillan Dictionary Blog.
Slightly sinister sock puppet image via Wikimedia Commons.
This entry was posted on Monday, September 24th, 2012 at 11:23 am and is filed under dialect, language, metaphor, morphology, words.	You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.
8 Responses to Irregular verbs, dialects, and sockpuppets
wisewebwoman says:
I've heard the term "sock puppet" used in lieu of the rather British "poodle" in describing political sycophants.
WWW: Oh yes, I had forgotten about that use of poodle. Seems it's been around for about a century, but it's a while since I heard it.
alexmccrae1546 says:
@www,
I wonder if the Brit term that you referenced,"poodle", used as a slang appellation for a political sycophant came about because of the 'lap-dog' connotation; in the political arena, a lap-dog suggests, perhaps, an individual having the character of a lackey, or fawning people-pleaser type person?
Although frankly, most 'real' poodles I've met (the yappy, four-legged, fluffy variety, that is), are far from compliant lap-dogs, but more like feisty little tyrants, loyal to their masters, to a fault. (I'll grant you, some individual poodles ARE very well behaved, and will take to one's lap, now and again. IMHO, always dangerous to generalize about a singular breed.)
My earliest exposure to an actual high-profile performing sock puppet had to be the TV character Lambchop, the adorable hand puppet so charmingly 'articulated' by ventriloquist/ puppeteer, Shari Lewis back in the early '60s. Shari had her own fairly long-running TV show which seemed to appeal to both young kids and adults, alike.
I believe she and Lambchop got their first major exposure on The Ed Sullivan Show, and Shari's stellar career took off from there.
Although Lambchop had sewn-on, pendulous, simulated 'wooly' lamb legs, he was still essentially a sock puppet character; wherein, Shari's deft hand movements within the sock mimicked Lambchop's talking action; the standard operational technique of sock puppetry performance.
Of course Ed Sullivan also provided a vast nationwide (and Canada) TV audience for the great Señor Wensless (sp. ?), who was basically a hand puppeteer, but without the sock prop.
As some of you early 'boomers' may recall, Wenless had this character, basically his scrunched-up hand w/ crudely draw eyes (at the base of his index finger), w/ lip stick on the inside of his thumb and index finger to simulate an open human mouth. Naturally, he would provide the voice, while manipulating his caricatured hand in sync w/ his schtick, as the camera stayed focused on his 'talking' hand.
Who knew that this very simple form of puppetry would become such an overnight sensation? Wensless (and his talented hand HA!) appeared innumerable times over the long run of Sullivan's highly-rated variety show.
The hand's classic line was, " it's all right…. it's all right." w/ a decidedly strong eastern European inflection.. (On the face of it, hardly hilarious….. but I guess you had to be there.)
A number of years back, those zany cartoon pranksters at Comedy Central's "South Park" did a very funny episode where Cartman, the obnoxious, pudgy, always-scamming character, decides to fashion a hand puppet, simulating the doppelganger of the super-star performer, Jennifer Lopez.
Much like the aforementioned Mr. Wensless, Cartman slathers on some lip stick, draws on a pair of large black eyes w/ huge eyelashes, and then tops it off w/ a jet black mini-hairpiece. He comes up w/ a very heavy Puerto Rican inflected singing/ talking voice for his Jennifer, which was a bit odd, since the actual Jennifer Lopez has hardly a hint of her Puerto Rican/ NYC-honed accent.
Of course, pure cartoon insanity ensues, as Cartman's fake Jennifer hand puppet eventually gets a major recording contract deal w/ the real Jennifer Lopez's record label, no less. (Lopez is released from her contract). The real Jennifer soon gets wind of this fake Jennifer interloper, is furious, and out for fatal revenge. Cat fight!
Well I could go on, but I believe i've overstayed my welcome as it is, and then some.
In the immortal words of the adorable Lambchop, "Not baaaaaaaaaaah-d, eh?"
Alex: It would be interesting to know just how that usage of poodle originated. We give dogs a hard time with these slang senses, so often stressing negative qualities. It reflects on us more than them, of course.
I'd heard of Lambchop, but my knowledge of Shari Lewis's creation and other work is sadly limited. Cartman's Jennifer Lopez is more familiar to me; it's a typically merciless turn! In Ireland, the puppets I knew best from childhood TV appeared in the Wanderly Wagon show, which I loved.
Just got my latest hardcopy issue of Newsweek in the post yesterday, and in their opening NEWSBEAST* section, under subject 'header' "Caveat Emptor", there's a shortish piece (p. 10) by staffer Josh Dzieza on 'detecting phony online reviews', w/ the article headline reading, "To Catch a Sock Puppet".
According to this article, the online arena of recently-released book reviewing is rife w/ sock puppetry, many authors praising their own works under several different aliases.
Apparently, some of the more careless self-promoting scribes will drop significant clues, or perhaps fail to cover their online cyber-tracks, and are, much to their embarrassment, eventually found out.
*Basically, Newsweek and the online news analysis/ commentary sight, The Daily Beast, have merged, several months ago, under the stewardship of editor-in-chief, the imitable, bright, and feisty Brit expat, Tina Brown.
Alex: Yes, it seems to be a very popular strategy for many authors. Which doesn't say much for their principles or for their confidence in the quality of their work.
John Cowan says:
I wonder if it would be possible to detect sock puppets by their characteristic use of irregular verbs and dialect forms!
Stan Carey says:
Probably, John. Forensic linguists and other stylometric specialists could definitely help uncover sock puppets, not only by looking at irregular and nonstandard usages but also by comparing more mundane items like the frequency of certain prepositions or a preference for certain adjectives.


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text:
A. If at first you don't succeed...
Each student eagerly awaits the day he would pass the exams successfully. Thus, Vasya was ready to celebrate, but, alas, he didn't pass it. However, many of Vasya's fellow students from the same group were more successful and celebrated after the exam.
Some of them celebrated in the BugDonalds restaurant, some of them — in the BeaverKing restaurant, the most successful ones were fast enough to celebrate in both of restaurants. Students which didn't pass the exam didn't celebrate in any of those restaurants and elected to stay home to prepare for their reexamination. However, this quickly bored Vasya and he started checking celebration photos on the Kilogramm. He found out that, in total, BugDonalds was visited by $$$A$$$ students, BeaverKing — by $$$B$$$ students and $$$C$$$ students visited both restaurants. Vasya also knows that there are $$$N$$$ students in his group.
Based on this info, Vasya wants to determine either if his data contradicts itself or, if it doesn't, how many students in his group didn't pass the exam. Can you help him so he won't waste his valuable preparation time?
The first line contains four integers — $$$A$$$, $$$B$$$, $$$C$$$ and $$$N$$$ ($$$0 \leq A, B, C, N \leq 100$$$).
If a distribution of $$$N$$$ students exists in which $$$A$$$ students visited BugDonalds, $$$B$$$ — BeaverKing, $$$C$$$ — both of the restaurants and at least one student is left home (it is known that Vasya didn't pass the exam and stayed at home), output one integer — amount of students (including Vasya) who did not pass the exam.
If such a distribution does not exist and Vasya made a mistake while determining the numbers $$$A$$$, $$$B$$$, $$$C$$$ or $$$N$$$ (as in samples 2 and 3), output $$$-1$$$.
The first sample describes following situation: $$$5$$$ only visited BugDonalds, $$$5$$$ students only visited BeaverKing, $$$5$$$ visited both of them and $$$5$$$ students (including Vasya) didn't pass the exam.
In the second sample $$$2$$$ students only visited BugDonalds and $$$2$$$ only visited BeaverKing, but that means all $$$4$$$ students in group passed the exam which contradicts the fact that Vasya didn't pass meaning that this situation is impossible.
The third sample describes a situation where $$$2$$$ students visited BugDonalds but the group has only $$$1$$$ which makes it clearly impossible.


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Diesel Engine Analysis
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1863: "We Are Making History"
October 22, 2018 October 22, 2018 / Sarah Kay Bierle
October 13, Tuesday (In Clarksburg)
Read the diary of an English officer who was in the Pennsylvania Campaign and at the Battle of Gettysburg. He was evidently penetrated with the Southern views on that occasion but his account of the battle is graphic and interesting. He scorns the idea of the Southern power being broken in that battle, but his account differs from what I hear in Virginia at Martinsburg.
October 14, Wednesday
…Visited the Old Academy and found Dr. Sherman installed there. We had a long talk about the war. We are making history which will make the nineteenth century memorable. It will one day be considered a great privilege to have lived in these days, to have played a part in the greatest war that has shaken the earth for many a year, to have been acquainted with the actors, leaders, and localities of so famous a drama – the crushing out of the last traces of feudalism in the United States.
October 16, Friday
…Talked to the mustering officer of this department. My regiment must be full in numbers and complete in companies before I can be legally mustered as colonel. Received the appointment of chief of cavalry for this department. Startling news that Lee was across the Rappahannock and that a general engagement was going on at the Old Bull Run battleground, and that Dan Sickles was at the head of the Army. This sounds bogus. A telegram from Martinsburg that two divisions of Longstreet's Corps were marching up Back Creek Valley to burn the railroad bridge. Some of Gilmor's men were really engaged in such an enterprise and thirty-nine of them were captured.
October 18, Sunday
…A squad of prisoners passed through yesterday, about twenty in number. Our own teamsters arrested for plundering their own wagons, stealing public property therefrom. The teamsters, as a rule, are the worst men we have about the army…
The movements look as if Lee was about to repeat his first Maryland Campaign. Kelley evidently thinks so and, contemplating the investment of Harpers Ferry, telegraphed Sullivan to hold it all hazards, even if Lee's whole army came against it. General Halleck seconds the order saying, "Any officer who would abandon it or surrender it deserves to be hung." This is the proper spirit…
Diary entries by David Hunter Strother (Union), October 1863
Arthur Freemantle
Personal diaries are great primary resources, but sometimes the names come rapid-fire, leaving readers wondering who's who. David Strother was especially good at recording the happenings and rumors without explaining background on the people – after-all, he knew these folks well or by reputation.
English Diarist – Arthur Freemantle, a British army officer, toured war-torn American in 1863 and did go campaigning with the Army of Northern Virginia. He did not officially represent England or Queen Victoria, but his observations on the war and presence encouraged the continued Confederate hopes of foreign intervention.
Dan Sickles – a problem political general at Gettysburg did not receive command of the Union Army of the Potomac. Strother was right to call this "bogus."
Harry Gilmor – a leader of Confederate cavalry in Western Virginia and the Shenandoah Valley
Benjamin F. Kelley – the Union commander of the department encompassing western Virginia and the Shenandoah Valley during the autumn of 1863
Jeremiah Sullivan – Kelley's son-in-law who had transferred to that military department to help guard the Baltimore and Ohio Railroad and other strategic points, like Harpers Ferry.
Henry Halleck – General-in-Chief of all Union armies. Known for firing off telegraphic messages from Washington and threatening generals who didn't perform well or win victories.
Imaginary Campaigns & Harpers Ferry
The rumored fight near "Old Bull Run battleground" likely referred to the Battle of Bristoe Station. In reality, Lee was not going to attempt another invasion of the north; he pulled the Confederate army back to the Central Virginia area.
However, the Union officers had every reason to worry about Harpers Ferry. That strategic town stood at a major transportation crossroads for rivers and railroads in Virginia (state of West Virginia to be modernly precise). It had been the location of the John Brown's Raid in 1859, gathering point for Confederate units early in the war, and would change hands eight times during the war. The previous year – 1862 – the Confederates under "Stonewall" Jackson had placed artillery on the heights above the town and captured it, taking prisoners and supplies during that Maryland Campaign. General Halleck didn't want another Harpers Ferry debacle and made a serious threat in 1863.
David H. Strother
David Strother mused on the importance of the Civil War and saw it as a turning point in American history. Significantly, he saw it as a social turning point. Slavery (last traces of feudalism, as he called it) would end, ushering in a new society to the South.
The war was a mighty conflict with far-reaching effects and changes. Even before the war's end was in sight, Strother started thinking about the coming differences and concluded that future generations would look back on the Civil War as a "famous drama" and counted it a privilege that he took back in "making history."
1863, 1863: In Their Words, autumn, David Hunter Strother, Harper's Ferry
← Tea With Sarah: Talking About World War I
History Read-Along: Gunner's Run, Chapters 15-17 →


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Sean Thomas	September 16, 2016
Slanted > Reviews > Tech Reviews > iPhone 7 Review
Apple's newest installment to the iPhone series wasn't a surprise, but it does offer a few choice upgrades for anyone looking for a new phone, or a newer iPhone.
Software aside, there is a substantial amount of new hardware in the newer models – which are called the iPhone 7 and the iPhone 7 Plus. Unlocking your new phone will present the first big change, you will notice a redesigned 'Home Button' straight away. Now you no longer press the home button to activate its features, you just simply hold your finger over it and apply light pressure. Now the button is more like the new trackpads on MacBook and Macbook Air models, not a gigantic change but one that should be pointed out. The new haptic feedback works as your button-press, and while it may be slightly different, it shouldn't really change the way you operate your phone. The new iOS 10 update got rid of the 'Swipe to Unlock' feature at start-up, which is much more of a difference than the newly designed home-button. If you find that the button is giving you trouble, you can simply adjust how much pressure is needed to 'press' the home button, that feature is available in the settings menu.
This haptic feedback is present throughout the phone's many functions. You can adjust how it operates with notifications, calls, confirmations, and it's used in some games and apps. The list of third-party apps that will use the technology is sure to grow, but just like the 3D Touch function, it will be up to the developer to incorporate the feature.
If you caught Apple's presentation this month then you probably are aware of Apple's obsession with color and brightness on the new iPhone 7 screen. Photography and video was a huge part of Apple's presentation this year, with Apple constantly reminding viewers of how marvelous their photos and videos will look with the new devices.
For the most part this is true. While the screens aren't exactly the best in the industry (at least by resolution or PPI) they are a great upgrade from last year's models. The entire 'wide color spectrum' that Apple promised earlier this month will make a tremendous difference when you're looking at pictures, or even some videos, but it will be up to social-media apps and video-streaming sites to optimize their platforms for use with the hardware. Instagram is one app that already promised to make upgrades to take advantage of the new hardware, and more apps are likely to follow suit over the next few months.
While these changes are all internal, how you use your iPhone really won't change at all. The operating system is iOS 10, which is available for previous models as well, and most of the functions and features are carry-over from last year's offerings. Operations, pictures, games and video are the big improvements, but it's more of a luxury upgrade than anything else.
Apple removing the headphone jack was the talk of the town when it was finally confirmed. That will most likely be the biggest change when upgrading or switching to the iPhone 7 model. If you are hesitant about the switch, Apple is offering an adapter if you have to have your classic headset input on-hand. Losing the headphone jack also helped make the iPhone 7 water resistant, which has been a standard in other phones for a while. You will get a fancy pair of EarPods, now with a lightning connecter, when you pick up your new iPhone 7 – but they aren't Apple's newest truly-wireless headphones – the AirPods. Those will set you back $150 and are basically what Apple will be pushing now that the headphone jack is gone.
Speaking of sound, stereo speakers finally came to the iPhone! The function has already been standard on other company's flagship phones for the last few years, but Apple finally came around and made it standard on the new iPhone 7. The sound is a vast improvement over previous generations, but it won't replace your favorite bluetooth speakers at this point.
Apple did improve the camera this time around, offering a 12MP camera on the back with optical image stabilization. The front FaceTime HD camera has been upgraded to 7MP, and using TrueTone flash, your selfies will look better than ever. The new ƒ/1.8 aperture will help you take better pictures in low-light areas, and the wide color capture will offer far better looking pictures than your iPhone 6 or 6 Plus ever could.
The iPhone 7 still offers a video-capture at 4K resolution, with built-in editing capabilities through iMovie. Thanks to the new two-camera system on the back, you can zoom in without losing resolution like you would in previous iPhones. The telephoto lens will allow a 10x zoom, but 5x seemed to be the point where the resolution started to drop off considerably. The dual-camera system will also allow you to create fantastic effects, if everything goes according to plan, which Apple demonstrated during its presentation. Apple's new camera system makes an appearance in the promotional video below.
All of these sound and visual improvements are enough to warrant putting an iPhone 7 on your compare list, but the hardware that runs it is also worth calling out. Tucked away inside the iPhone 7 is the all-new A10 Fusion chip, designed with four cores to balance power and efficiency.
There are two high performance cores, which handle your work-heavy tasks like video-streaming and games, and two low-power cores that conserve battery while maintaining your general tasks like notifications and synching. Apple has always had terrific processors in the company's iPhone line, they are some of the best in the industry, and the A10 Fusion is a perfect addition to Apple's lineup.
You won't really notice a difference until you start putting the phone through a workout, but it has plenty of power to keep up with event the heaviest of multitaskers and gamers.
If you are using an iPhone 5, or 5C, the upgrade to an iPhone 7 will be substantial. Features aside, the hardware upgrade alone will make your daily use with the phone much more enjoyable. Things start to get murky when you suggest upgrading from the iPhone 6S or the iPhone 6S Plus. These were terrific installments to the iPhone line, and their hardware really hasn't been maxed out by iOS 10 or by third-party apps at this point. The new iPhone 7 line will surely be faster, offer better sound, and has a better camera and screen, but not so much so that I would say everyone should upgrade immediately.
I think everyone hopes that Apple dramatically redesigns the iPhone with every new installment, and when the changes are incremental, it can seem like a disappointment. Apple has found great success with a steady stream of upgrades, which may be small, but are aimed at power and efficiency. You'll find both in the new iPhone 7, but you'll find even more when Apple eventually announces the iPhone 7S or iPhone Plus (whatever it's name finally is). In any case the phone is a magnificent device, Apple continues to lead the industry in both sales and with a lot of its specs, but a jump to the iPhone 7 should be from a phone that it leaps ahead of, not one that is just marginally inferior.
Sean Thomas September 16, 2016
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Sean Thomas August 17, 2016


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Predicting 2020 NBA All-Star Starters
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Home /Are the Impossible Burger, Beyond Burger healthier than real beef? Its complicated
Are the Impossible Burger, Beyond Burger healthier than real beef? Its complicated
We tried the new plant-based Impossible burger and compared it to Beyond Meat.
More restaurants and supermarkets are adopting environmentally conscious, plant-based foods that taste, smell and look nearly identical to traditional beef burger patties.
Last month, the Impossible Burger made its grocery debut in all 100 Wegmans grocery stores in seven states while Burger King continued to sell the plant-based Impossible Whopper nationwide.
Similarly, the company's competitor Beyond Meat scored a 12-week test run of the Beyond Burger at select locations for one of the world's largest restaurant chains – McDonald's.
While these meatless burgers have been proven to be better for the environment, some question whether they're nutritionally better than beef.
Here's a deep dive into the nutrition label.
What are the ingredients in an Impossible Burger?
A first glance at the nutrition label shows Impossible Burgers are almost identical to traditional beef burgers.
They're both about 240 calories and contain about 8 grams of saturated fat. However, a few key differences set them apart.
One difference is the amount of sodium in a traditional beef burger versus an Impossible Burger. Beef contains very little sodium, unless added independently when cooking, whereas Impossible Burgers contain 370 milligrams or 16 percent of the daily value.
According to the American Heart Association, the ideal intake of sodium per day is 1,500 milligrams.
Dr. Sue Klapholz, vice president of Nutrition & Health at Impossible Foods, says the company's research and development team are working to decrease the amount of sodium and saturated fat in the product.
"Even if we think we can be healthy, we can always be healthier," she said. "We're always going to strive to be better."
Klapholz argues that the Impossible Burger should have no problem fitting into a low sodium diet for people who have hypertension or are just looking for less sodium intake with their food.
Shalene McNeill, executive director of nutrition science, health and wellness at the National Cattlemen's Beef Association, says that if meat-eaters are looking for a way to get more protein in their diet with less sodium – then just turn back to beef.
"You're not getting any nutritional advantage; some would argue that you're getting less quality because it's not natural nutrients and has more sodium," she said. "You could just eat the beef you love with a salad or butternut squash."
The "not natural nutrients" McNeill referenced is the genetically modified heme iron that Impossible Burger adds to their product to create that juicy red color and beefy taste.
Heme is a high-quality iron that is naturally present in all beef. Impossible Foods was able to re-create that essential nutrient by taking the DNA from soybean plants, where heme is found in the root nodules, and inserting it into a genetically engineered yeast, according to its website.
The Food and Drug Administration approved the genetically modified heme as "generally recognized as safe," or GRAS, in July 2018.
Beyond Meat vs. Impossible Burger vs. traditional beef
Nutrition experts are divided on how meatless burgers fit into daily, balanced diets due to the lack of research surrounding the genetically modified heme iron created by Impossible Foods.
Beyond Meat does not include heme iron in its burger and instead, relies on plant-based iron. Heme iron is more absorbable to the body than plant-based iron, but a company spokesperson says Vitamin C is added to increase that absorbability.
When comparing the nutrition labels, the Beyond Burger has less saturated fat, more protein and fewer carbohydrates than the Impossible Burger.
In comparison to a traditional beef burger, both brand burgers have less protein, a lot more sodium and, of course, more carbohydrates.
Experts are still trying to figure out how meat-mimicking alternatives fit into the larger picture of the daily diet. McNeill argues the trend is actually creating mixed signals for people who want to eat healthier.
"We want you to incorporate vegetables and fruits because people aren't eating enough of those," she said. "But where that's getting lost is that you don't need to do that in place of meat. They're a perfect match."
However, Klapholz believes the Impossible Burger will surpass the nutritional benefits of beef in the future.
"As far as a product, we always want to be as healthy and nutritious or more than whatever we are replacing," she said. "The cow is the cow – it's not going to evolve to meet people's nutrient needs."
Vegans & vegetarians: What you need know
Vegans and vegetarians, who make up about 3 percent and 5 percent of Americans, respectively, might think twice about jumping into the meat-mimicking trend as they may be contributing to their carbon footprint.
For example, coconut oil is the source of the saturated fat in both the Impossible Burger and Beyond Burger. This ingredient has to be imported into the United States.
A 2018 study for the Beyond Burger showed that it produced 90 percent less greenhouse gas emissions than a quarter pound of U.S. beef, even when the impact of importing and transporting raw ingredients was assessed, according to a Beyond Meat spokesperson.
The process is more environmentally conscious than livestock production, but vegans and vegetarians never contributed to the beef industry's carbon footprint in the first place.
Could they unintentionally be contributing to a different carbon footprint by adding these meatless burgers to the menu?
Klapholz says it depends on what vegans and vegetarians are substituting in their diet. Other popular, meatless products frequently consumed by people with dietary restrictions also have to be imported to the United States.
She also adds that vegetarians and vegans are not the audiences that Impossible Foods want to target.
"Our target audience is the meat eater and over 90 percent of consumers identify as meat eating individuals," she said. "Vegans and vegetarians are already doing the right thing."
Follow Adrianna Rodriguez on Twitter: @AdriannaUSAT
Read or Share this story: https://www.usatoday.com/story/news/health/2019/10/25/burger-kings-impossible-burger-veggie-whopper-healthy/4070993002/
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FCUM Radio is proud to debut our brand new arts and cultural programme in Podcast form. Join host Mugabi Turya each week for Inside Manchester, as he lifts the lid on this fair city of ours with those people who make this place what it is. In the first edition this week, its an Inside Manchester Zine Special, with particular focus on The Salford Zine Library, The Shrieking Violet publication, The Colouring Box, and Lottie Smith. We'll be hearing from all of these lovely people during this week's show.


text:
Understanding the role of the kynurenine pathway in human breast cancer immunobiology
Benjamin Heng, Chai K. Lim, David B. Lovejoy, Alban Bessede, Laurence Gluch, Gilles J. Guillemin*
Breast cancer (BrCa) is the leading cause of cancer related death in women. While current diagnostic modalities provide opportunities for early medical intervention, significant proportions of breast tumours escape treatment and metastasize. Gaining increasing recognition as a factor in tumour metastasis is the local immuno-surveillance environment. Following identification of the role played by the enzyme indoleamine dioxygenase 1 (IDO1) in mediating maternal foetal tolerance, the kynurenine pathway (KP) of tryptophan metabolism has emerged as a key metabolic pathway contributing to immune escape. In inflammatory conditions activation of the KP leads to the production of several immune-modulating metabolites including kynurenine, kynurenic acid, 3-hydroxykynurenine, anthranilic acid, 3-hydroxyanthranilic acid, picolinic acid and quinolinic acid. KP over-activation was first described in BrCa patients in the early 1960s. More evidence has since emerged to suggest that the IDO1 is elevated in advanced BrCa patients and is associated with poor prognosis. Further, IDO1 positive breast tumours have a positive correlation with the density of immune suppressive Foxp3+ T regulatory cells and lymph node metastasis. The analysis of clinical microarray data in invasive BrCa compared to normal tissue showed, using two microarray databank (cBioportal and TCGA), that 86.3% and 91.4% BrCa patients have altered KP enzyme expression respectively. Collectively, these data highlight the key roles played by KP activation in BrCa, particularly in basal BrCa subtypes where expression of most KP enzymes was altered. Accordingly, the use of KP enzyme inhibitors in addition to standard chemotherapy regimens may present a viable therapeutic approach.
https://doi.org/10.18632/oncotarget.6467
Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
10.18632/oncotarget.6467
Publisher version (open access).pdfFinal published version, 2.28 MB
Dive into the research topics of 'Understanding the role of the kynurenine pathway in human breast cancer immunobiology'. Together they form a unique fingerprint.
Kynurenine Medicine & Life Sciences 100%
Dioxygenases Medicine & Life Sciences 35%
3-Hydroxyanthranilic Acid Medicine & Life Sciences 14%
Early Medical Intervention Medicine & Life Sciences 14%
3-hydroxykynurenine Medicine & Life Sciences 13%
Enzymes Medicine & Life Sciences 13%
picolinic acid Medicine & Life Sciences 13%
Heng, B., Lim, C. K., Lovejoy, D. B., Bessede, A., Gluch, L., & Guillemin, G. J. (2016). Understanding the role of the kynurenine pathway in human breast cancer immunobiology. Oncotarget, 7(6), 6506-6520. https://doi.org/10.18632/oncotarget.6467
Heng, Benjamin ; Lim, Chai K. ; Lovejoy, David B. ; Bessede, Alban ; Gluch, Laurence ; Guillemin, Gilles J. / Understanding the role of the kynurenine pathway in human breast cancer immunobiology. In: Oncotarget. 2016 ; Vol. 7, No. 6. pp. 6506-6520.
@article{36d173198aa3465f812ae2050484c384,
title = "Understanding the role of the kynurenine pathway in human breast cancer immunobiology",
abstract = "Breast cancer (BrCa) is the leading cause of cancer related death in women. While current diagnostic modalities provide opportunities for early medical intervention, significant proportions of breast tumours escape treatment and metastasize. Gaining increasing recognition as a factor in tumour metastasis is the local immuno-surveillance environment. Following identification of the role played by the enzyme indoleamine dioxygenase 1 (IDO1) in mediating maternal foetal tolerance, the kynurenine pathway (KP) of tryptophan metabolism has emerged as a key metabolic pathway contributing to immune escape. In inflammatory conditions activation of the KP leads to the production of several immune-modulating metabolites including kynurenine, kynurenic acid, 3-hydroxykynurenine, anthranilic acid, 3-hydroxyanthranilic acid, picolinic acid and quinolinic acid. KP over-activation was first described in BrCa patients in the early 1960s. More evidence has since emerged to suggest that the IDO1 is elevated in advanced BrCa patients and is associated with poor prognosis. Further, IDO1 positive breast tumours have a positive correlation with the density of immune suppressive Foxp3+ T regulatory cells and lymph node metastasis. The analysis of clinical microarray data in invasive BrCa compared to normal tissue showed, using two microarray databank (cBioportal and TCGA), that 86.3% and 91.4% BrCa patients have altered KP enzyme expression respectively. Collectively, these data highlight the key roles played by KP activation in BrCa, particularly in basal BrCa subtypes where expression of most KP enzymes was altered. Accordingly, the use of KP enzyme inhibitors in addition to standard chemotherapy regimens may present a viable therapeutic approach.",
author = "Benjamin Heng and Lim, {Chai K.} and Lovejoy, {David B.} and Alban Bessede and Laurence Gluch and Guillemin, {Gilles J.}",
note = "Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",
doi = "10.18632/oncotarget.6467",
journal = "Oncotarget",
publisher = "Impact Journals",
Heng, B, Lim, CK, Lovejoy, DB, Bessede, A, Gluch, L & Guillemin, GJ 2016, 'Understanding the role of the kynurenine pathway in human breast cancer immunobiology', Oncotarget, vol. 7, no. 6, pp. 6506-6520. https://doi.org/10.18632/oncotarget.6467
Understanding the role of the kynurenine pathway in human breast cancer immunobiology. / Heng, Benjamin; Lim, Chai K.; Lovejoy, David B.; Bessede, Alban; Gluch, Laurence; Guillemin, Gilles J.
In: Oncotarget, Vol. 7, No. 6, 09.02.2016, p. 6506-6520.
T1 - Understanding the role of the kynurenine pathway in human breast cancer immunobiology
AU - Heng, Benjamin
AU - Lim, Chai K.
AU - Lovejoy, David B.
AU - Bessede, Alban
AU - Gluch, Laurence
AU - Guillemin, Gilles J.
N1 - Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
N2 - Breast cancer (BrCa) is the leading cause of cancer related death in women. While current diagnostic modalities provide opportunities for early medical intervention, significant proportions of breast tumours escape treatment and metastasize. Gaining increasing recognition as a factor in tumour metastasis is the local immuno-surveillance environment. Following identification of the role played by the enzyme indoleamine dioxygenase 1 (IDO1) in mediating maternal foetal tolerance, the kynurenine pathway (KP) of tryptophan metabolism has emerged as a key metabolic pathway contributing to immune escape. In inflammatory conditions activation of the KP leads to the production of several immune-modulating metabolites including kynurenine, kynurenic acid, 3-hydroxykynurenine, anthranilic acid, 3-hydroxyanthranilic acid, picolinic acid and quinolinic acid. KP over-activation was first described in BrCa patients in the early 1960s. More evidence has since emerged to suggest that the IDO1 is elevated in advanced BrCa patients and is associated with poor prognosis. Further, IDO1 positive breast tumours have a positive correlation with the density of immune suppressive Foxp3+ T regulatory cells and lymph node metastasis. The analysis of clinical microarray data in invasive BrCa compared to normal tissue showed, using two microarray databank (cBioportal and TCGA), that 86.3% and 91.4% BrCa patients have altered KP enzyme expression respectively. Collectively, these data highlight the key roles played by KP activation in BrCa, particularly in basal BrCa subtypes where expression of most KP enzymes was altered. Accordingly, the use of KP enzyme inhibitors in addition to standard chemotherapy regimens may present a viable therapeutic approach.
AB - Breast cancer (BrCa) is the leading cause of cancer related death in women. While current diagnostic modalities provide opportunities for early medical intervention, significant proportions of breast tumours escape treatment and metastasize. Gaining increasing recognition as a factor in tumour metastasis is the local immuno-surveillance environment. Following identification of the role played by the enzyme indoleamine dioxygenase 1 (IDO1) in mediating maternal foetal tolerance, the kynurenine pathway (KP) of tryptophan metabolism has emerged as a key metabolic pathway contributing to immune escape. In inflammatory conditions activation of the KP leads to the production of several immune-modulating metabolites including kynurenine, kynurenic acid, 3-hydroxykynurenine, anthranilic acid, 3-hydroxyanthranilic acid, picolinic acid and quinolinic acid. KP over-activation was first described in BrCa patients in the early 1960s. More evidence has since emerged to suggest that the IDO1 is elevated in advanced BrCa patients and is associated with poor prognosis. Further, IDO1 positive breast tumours have a positive correlation with the density of immune suppressive Foxp3+ T regulatory cells and lymph node metastasis. The analysis of clinical microarray data in invasive BrCa compared to normal tissue showed, using two microarray databank (cBioportal and TCGA), that 86.3% and 91.4% BrCa patients have altered KP enzyme expression respectively. Collectively, these data highlight the key roles played by KP activation in BrCa, particularly in basal BrCa subtypes where expression of most KP enzymes was altered. Accordingly, the use of KP enzyme inhibitors in addition to standard chemotherapy regimens may present a viable therapeutic approach.
U2 - 10.18632/oncotarget.6467
DO - 10.18632/oncotarget.6467
JO - Oncotarget
JF - Oncotarget
Heng B, Lim CK, Lovejoy DB, Bessede A, Gluch L, Guillemin GJ. Understanding the role of the kynurenine pathway in human breast cancer immunobiology. Oncotarget. 2016 Feb 9;7(6):6506-6520. https://doi.org/10.18632/oncotarget.6467


The man hesitated before obeying.
She looked troubled, and hesitated a moment before answering.
Alex hesitated and looked at Carmen.
Jim hesitated, eyeing the beasts fearfully.
For another moment she hesitated, and then joined Alex.
Howard hesitated and shot a questioning glance at Connie, who shrugged and turned away.
When she still hesitated his expression became exasperated.
For a moment she hesitated, and then accelerated.
Though he hesitated, and perhaps failed to express himself distinctly, he always had a presentable thought behind.
Only when a man was killed or wounded did he frown and turn away from the sight, shouting angrily at the men who, as is always the case, hesitated about lifting the injured or dead.
She hesitated for an instant whether to speak or not.
Darian hesitated, and fury filled Dusty.
"Well …" She hesitated, surprised at his persistence.
He hesitated before hugging her.
Connie hesitated, and then spoke excitedly.
She hesitated and then joined him.
Her heart hesitated a moment, contracting for a race.
Quint hesitated a moment, watching Lisa with an uncertain expression.
She hesitated then asked, "Can you call someone to come get me?"
He hesitated, studying her face with a puzzled expression.
They followed his parents into the house and Adrienne hesitated at the dining room door.
She hesitated and gnawed on her lower lip.
But she had hesitated long enough to lend him encouragement.
He hesitated, caution in his voice.
She hesitated, but saw I still held the knife by my side.
Dusty hesitated and then snatched his dinner before he did something they'd both regret.
She started forward, then hesitated a moment, evidently debating within herself whether she would go or not.
Carmen hesitated, catching Alex's eye.
She hesitated, drawing a deep breath before continuing.
She hesitated, her expression pensive.
She mounted the ATV behind him and hesitated before putting her arms around his waist.
She hesitated, wanting to find a way home, but not wanting to ask any more favors of him.
He hesitated, looking down at his feet as he spoke.
Lisa hesitated, not wanting to pry and not sure if the conversation was supposed to end there.
Jonny hesitated then looked up finally.
At that moment, as the Horse Guards, having passed him, disappeared in the smoke, Rostov hesitated whether to gallop after them or to go where he was sent.
He hesitated, his gaze becoming intense.
She hesitated as his troubled gaze ran over her face.
"Yes," she hesitated, biting her lower lip.
For a moment she hesitated, remembering their last discussion.
Lisa hesitated, not wanting to alarm her friend with the details.
Lisa hesitated, afraid of blundering further, but why did he need a sitter when his mother lived in the house?
She hesitated, gazing down the hallway, and her expression grew solemn.
She hesitated, glancing at Lisa.
She hesitated, staring up at his face.
She hesitated, intimidated by his obvious displeasure.
When he hesitated, I added, "I've come a long way."
Betsy hesitated, but complied when Grasso feigned a slice with his weapon.
He hesitated, then shook his head.
She hesitated before taking his hand.
He hesitated, visibly unsettled by what she knew were her spinning silver-blue eyes.
He hesitated then wrapped his arms around her, resting his cheek against her head.
She hesitated then reached for him, her cool touch soothing the fury in his blood.
She hesitated then texted him.
He hesitated, and her senses tingled in warning.
She hesitated at the head of the stairs, tormented by the knowledge her father was incapable of mercy towards his daughter, let alone a stranger.
Jule hesitated only a moment longer before he cupped her face in his hands and kissed her.
She hesitated, sensing that entering his domain would somehow seal her to a fate she didn't yet understand.
Sometimes I bolted suddenly, and nobody could tell my whereabouts, for I did not stand much about gracefulness, and never hesitated at a gap in a fence.
Pierre hesitated, not knowing what to do, and glanced inquiringly at his guide.
Here Balashev hesitated: he remembered the words the Emperor Alexander had not written in his letter, but had specially inserted in the rescript to Saltykov and had told Balashev to repeat to Napoleon.
He hesitated, his expression turning wary.
He hesitated and then went on.
My fiancée gave me a cold eye as I hesitated before answering.
Removing the laundry from her room, she walked down the hall and hesitated at Cade's bedroom door.
Iggy hesitated, and Dusty's gaze sharpened.
She hesitated at Señor Medena's desk and he glanced up at her expectantly.
She hesitated a moment, wanting to tell him, but thinking she would be betraying Yancey if she did so.


June 2018 – Dc to a "T"
Wedding season is in full swing, but the "something old, something new" in this post title actually refers to…you guessed it…furniture styling. As you may know if you follow me on Instagram, I scored an awesome pair of cane chairs off of Craigslist this past Sunday for only $15 each! It was a dream come true (even though I had to travel pretty far out to the Virginia suburbs to grab them–though I took the metro one way and then Ubered back with them, though, so it wasn't too pricy of an excursion). Side note: the seller had originally listed all five chairs for $75 total, and while it was a huge steal, I just realllllyyy don't have the room for all of them. I emailed her asking if she was willing to break up the set (though keep in mind that some people are sticklers about not doing this), and luckily, she was, which made it super easy for me to head to her place and grab two (I also lucked out because not all of the chairs were in great condition, so I was able to pick out the least flawed ones).
While I was excited about the chairs, I did worry that they were maybe a little too old-looking/grandma-ish for a 26 year old. I knew I could style them and make them look fun, but I wasn't (and still am not) exactly sure how. I've tried placing my fun leopard print pillow on one and a faux fur throw on the other (which is cute, but also necessary, as the seat on that chair is pretty torn up). After browsing Pinterest and crowd-sourcing on Instagram, I've decided that while gold/white/black spray painted cane chairs look cool, the original wood finish is pretty special and worth keeping. (Sorry for the weird lighting in these photos–one was taken during a super sunny afternoon, and one was in the morning before work, when it's also very bright in this spot!).
So how can I create a fairly modern setup with all of this wooden furniture? It's all in the styling. I placed the chairs next to the cane love seat I have, which is obviously also old-looking, but the lucite tables next to them add a more young, modern look. After all, I'll only be in my twenties and living on my own/with a roommate for a limited period of time, so I don't want to create a look that's too "grown up" or stuffy just yet!
I think my gallery wall also helps offset the stuffy vibe–it's filled with fun prints (some older-looking, and some more modern) that are colorful and whimsical. The gold lamp from Target is 100 percent young and modern-looking while also being functional. Plus, greenery is always key in making a room look more fresh and alive, literally! Plants are so easy to use as decor–just place one in an empty space and there's no need to splurge on a side table.
I also think a purely modern piece–like a fun moroccan pouf or Eames chair replica–does a great job of taking a space from granny to millennial. Mixing and matching vintage pieces with finds like these will go a long way!
While I'm far from a DIY expert, I love knocking out a spray paint or sanding project in my spare time. It's so satisfying seeing a piece of furniture go from blah to beautiful in a matter of hours. However, I've also started several projects that ended up being huge flops, and I know plenty of other people can relate! Here are some things I've learned from my DIY drama.
1) Patience is key. It may be tempting to start that spray paint project on a super hot or windy day because it's the only free weekend you'll have for awhile, but you'll only end up more frustrated if you begin your work under less than ideal conditions. Check the weather (especially during the summer) to determine whether spray paint will hold or just end up all messy, and if you need to wait a few weeks, it won't be the end of the world–you'll thank yourself when your final product looks amazing!
2) Be realistic. I've done some DIY projects that I'm super proud of and others that have made me want to start crying! The end result likely won't be as pretty as the images you see on Pinterest, so if you would feel more comfortable enlisting a friend or professional to help, do it. Even if you snag a cool vintage piece that's seen better days for cheap and pay someone else to refinish and paint it, it will likely still be a better deal than buying a completed piece from the local antique shop.
3) Do your research. I've found that asking questions at the hardware store and doing some Googling can really help–it's better to be safe than sorry, especially when purchasing your materials.
4) Painting over paint isn't always a great idea. I've learned the hard way that painting over an existing paint color is super difficult and doesn't always look great, even if you sand beforehand. As noted in the point above, do your research and figure out if the project you have in mind makes sense to take on, or if it's better to leave a painted item as is and live with it.
5) Dress accordingly. It seems like a no brainer, but there have definitely been times where I've figured plastic gloves would suffice and of course ended up getting spray paint all over my jeans. Wear old clothes and cover your hands; you'll thank me later!
What DIY tips do you have? I'm more of a painter/refinisher but would love to hear what it's like to build something from scratch…I haven't been that ambitious thus far, but I love the look of custom pieces.


Today only, as a part of its Gold Box Deals of the Day, Amazon is offering the Best of Warner Bros. 100 Film Collection on DVD for $63.99 shipped. For comparison, it has a list price of $598 and sold for as much as $350 just last month. Today's deal is a new Amazon all-time low. We're talking 100 films here for under $1 each. Rated 4.1/5 stars.
The World's Largest Film Collection From a Major Studio! 100 movies including all 22 of Warner Bros. Library's Best Picture winners on 55 discs presented in book style premium packaging. Plus two all-new documentaries: Tales from the Warner Bros. Lot and The Warner Bros. Lot Tour. With hours of commentaries, behind-the-scenes featurettes and more on select films. Also includes a limited edition 27″ x 40″ poster, plus a postcard series of Warner Bros. movie posters designed by legendary Bill Gold. Look for these movie-poster titles on DVD.


text:
In an Age of disposable fashion, This Omega Speedmaster Can Stand the Test of Time – The First Watch on the Moon
HomeAll PostsWatch RepairIn an Age of disposable fashion, This Omega...
17th July 2019 By FixMyWatch
We couldn't lose this opportunity to jump on the NASA band wagon and throw up some pictures of a classic, an Omega Speedmaster, "The First Watch Worn on the Moon".
Some may wonder what is so special about this particular watch. Why does it have such an appeal to watch aficionados and collectors? Why does the wearer have such pride in owning this watch? Some are pushovers for nostalgia, some love the aesthetics and some appreciate the different levels of detail and subtle differences between each release and iteration of this Omega Speedmaster. We just think it's very cool!
Commonly dubbed the greatest achievement of the 20th Century, whether you believe it or not, sending man to the moon is an unbelievable feat of human engineering and such an incredible triumph of modern civilisation. If you had the opportunity to own a piece of that technology and use it daily, wouldn't you be proud to wear it? That is exactly what the Omega Speedmaster is.
This watch is the only one to have been flight-qualified by NASA for all manned space missions. Just think, if you suddenly found yourself on the millennium falcon, you'd be happy you were wearing your Speedmaster'.
So why do we care about this watch in today's world? We have mobile phones that tell the time, Apple Watches that can do a lot more than tell the time, £15.00 Casio's bought from Amazon and fashion brands such as Armani and Michael Kors. Great, however, can they run forever? Without getting into the black hole that is planned obsolescence, high quality, manufactured mechanical watches do not rely on external factors to ensure it works. If serviced every few years and wound every day, well maintained mechanical watches such as the Omega Speedmaster can last forever. They don't need charging overnight with your home electricity, nor will you be lost for information if the mobile signal is too weak. Its design is classic and it's mechanism is everlasting.
In a modern world of disposable items and the latest version replacing the last for a low cost, there is an appeal to owning something that can be passed on to further generations. Watches such as the Omega Speedmaster provide a sense of permanence ion a world that cannot.
Our words and images may not instil the same sense of passion that encompasses an Omega Speedmaster owner, but believe us when we tell you that these watches are a feat of engineering and creativity. To be able to go to the moon and back, they must be pretty special.
If you have an Omega Speedmaster and want to ensure it stands the test of time, Our Omega authorised watchmakers can provide you with a full service, restoration or even a timing and accuracy check or pressure test and gasket change. Get a price for your Omega watch repair HERE.
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At FixMyWatch we appreciate that time is a valuable asset in people's busy schedules; that's why we've developed what is probably the best watch repair service available anywhere in the world
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