Pfizer abandoned its attempt to buy AstraZeneca for nearly 70 billion pounds ($118 billion) on Monday as a deadline approached without a last-minute change of heart by the British drugmaker.
AstraZeneca welcomed Pfizer's decision to abandon an attempt to buy the British drugmaker, which AstraZeneca said would allow it to focus on its growth as a standalone business.
Pfizer's chances of striking a deal to buy AstraZeneca in the coming days look vanishingly small, but the notion it could return later this year is propping up the British drugmaker's shares.
AstraZeneca's shareholders remain split over the UK pharmaceuticals giant's decision to reject a $118 billion offer from U.S. rival Pfizer , with AXA coming out against it Threadneedle supporting it.
Britain's AstraZeneca on Monday rejected a sweetened and "final" offer from Pfizer, puncturing the U.S. drugmaker's plan for a merger to create the world's biggest pharmaceuticals group.
Pfizer Inc may have called its $118 billion bid for AstraZeneca Plc a "final" offer, and its British rival sees no prospect of a deal being revived. But Wall Street isn't ready to call in the undertakers.
U.S. drugmaker Pfizer has left itself no room to return with a higher offer for AstraZeneca before a deadline expires next Monday due to Britain's strict takeover rules, even if the British firm wanted it to, experts say.
The chairman of Britain's AstraZeneca said on Monday he saw no prospect of a deal with U.S. drugmaker Pfizer before a deadline of May 26 set under UK takeover rules, or any likelihood of that deadline being extended.
Britain's Jupiter Fund Management, a top-30 shareholder in UK pharmaceuticals giant AstraZeneca, said it is disappointed with the firm's rejection of U.S. rival Pfizer's final takeover offer.
U.S. drugmaker Pfizer is likely to court major investors in AstraZeneca as part of a takeover attempt despite a board rejection of its 70 billion pounds ($118 billion) bid, the head of Britain's parliamentary science committee said.


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Yards plan increased capacity
By John Mueller Wednesday, 17 February 2010 18:00
Even with fewer newbuild orders, optimism about future growth is rife with sustained efforts to obtain more yard capacity, both in Asia and on more distant shores. John Mueller reports.
The drive to acquire greater building capacity ranges from MMHE in Malaysia adding a pier to an ambitious plan by Sembcorp Marine to establish an entirely new shipyard in Brazil, in the footsteps of Keppel Corporation, where Keppel Offshore & Marine is branching out with the construction of a tension leg wellhead platform at its BrasFels yard.
MMHE concluded 2009 with completion of its West Finger Pier (WFP) project by Samsung Heavy Industries, at its Pasir Gudang Shipyard in Johor, Malaysia.
WFP is a 300m pier designed to berth VLCCs and effect FPSO repair and conversion works, and a 100m long material handling quay to accommodate delivery barges up to 5000dwt.
CNOOC is constructing a deepwater engineering base in the Gaolan Port Economic Zone in Zhuhai, Guangdong Province, China, which is expected to become a marine engineering equipment manufacturing centre within the next five years.
The facility, involving an investment of $730 million, will manufacture offshore oil and gas field equipment.
Jurong Shipyard (JSL), a Sembcorp Marine subsidiary, is to build a new shipyard in Brazil on a freehold land area of 825,000m2, over one and a half times larger than JSL's Tanjong Kling, Singapore location. The new yard, with 1.6km of coastline in Espirito Santo, Brazil, will be capable of constructing drilling rigs, FPSO integration, topside fabrication, and repairs and modification works.
Wong Weng Sun, president and CEO of Sembcorp Marine said: 'We have been a key player in Brazil's oil and gas construction industry since 1997, having delivered to-date a total of 11 units of oil and gas exploration, production and storage platforms for Brazilian oilfields. These platforms produce more than half of Petrobras' daily two million barrels output, thus effectively making JSPL the main contractor to Petrobras.'
Engineering design for the new shipyard has commenced, with development to be undertaken in stages.
Also in Brazil, Keppel O&M;will have its subsidiary KFels build a TLWP at its BrasFels yard in Angra dos Reis for FloaTec Singapore, a 50:50 JV of KFels and J Ray McDermott. FloaTec signed a contract worth about $1 billion with the Papa-Terra JV, consisting of Petrobras and Chevron, to build and operate the P-61 TLWP, which will be installed in the Campos Basin on completion mid-2013.
Jackups
Aramco Overseas Company, a subsidiary of Saudi Aramco, has contracted Keppel Fels (KFels) to build a customised KFels Super B Class jackup drilling rig, to be s delivered in 2H 2012, for deployment in the Middle East.
Dragon Oil (Turkmenistan) has awarded Yantai Raffles Offshore a contract for an undisclosed sum to construct a Friede & Goldman Super M2 design jackup drilling rig capable of drilling in up to 300ft of water to a depth of 30,000ft, to be delivered in 4Q 2011.
Yantai Raffles, based in Yantai, China, and partners will lease and manage the rig for five years, TSC Offshore China will supply all drilling related equipment, and Momentum Engineering will act as main drilling contractor.
Dragon Oil operates oilfields in the Cheleken contract area offshore Turkmenistan in the southeastern Caspian Sea.
China Oilfield Services (COSL) has taken delivery of two jackup drilling rigs, COSL 936, a Gusto MSC design built by China Merchants Heavy Industry (Shenzhen), and COSL 937, built by Dalian Shipbuilding Industry. Both rigs, capable of drilling to 30,000ft in 300ft water depths, will operate in Bohai Bay.
Perforadora Central, of Mexico, has received the jackup drilling rig Tuxpan, the first delivery of 2010 from Keppel AmFels, US-based subsidiary of Keppel O&M.;Keppel AmFels is constructing four other newbuild LeTourneau Super 116E units, for Rowan Companies.
Semisubmersibles
Daewoo Shipbuilding & Marine Engineering (DSME) has announced that an unnamed client in the Americas has engaged the company to build a semisubmersible drilling rig valued at $500 million by late 4Q 2011. The vessel will be able to drill to 40,000ft in water up to 10,000ft deep.
Seadrill has taken delivery of the semisubmersible drilling tender rig West Vencedor, a KFels SSDT 3600E design, the sixth of seven SSDTs the Singapore yard is fabricating for Seadrill. The tender, able to operate in water depths up to 5000ft, is to commence development drilling offshore Angola under a five-year contract for Chevron subsidiary Cabinda Gulf Oil early this year.
Floatel International is on track to take delivery of the semisubmersible floating accommodation rig Floatel Superior this quarter, the first of two such newbuilds from KFels in Singapore.
The DNV-classed vessel, the only newbuild floatel in full compliance with all Norwegian sector regulations and able to cater to 220 personnel, will be chartered by ConocoPhillips Australia.
Transocean is having KFels repair and perform life extension works on the deepwater semisubmersible MG Hulme Jr that include installation of a new accommodation block and helideck, the vessel to be deployed to Libya for Gazprom on completion.
Yantai Raffles Shipyard has achieved the heaviest ever commercial lift using its 20,000t Taisun crane at the yard in Yantai, China, with placement of the deckbox for Saipem's semisubmersible drilling rig Scarabeo 9, a sixth generation DP3 ultradeepwater Frigstad D90 design.
Drillships
DSME is reported to have secured a $1.1 billion award to construct two drillships for Petroleo Brasileiro, to be completed 1Q 2012. The vessels will be able to drill to 40,000ft in water depths up to 10,000ft.
Noble Corporation has awarded Keppel Fels Brasil, a subsidiary of Keppel O&M, a $152 million contract to upgrade and repair a third Brazil-based drillship, Noble Muravlenko, bringing the total value of drillship contracts recently secured from Noble to $456 million.
Late last year Noble awarded Keppel upgrading work for the drillships Noble Leo Segerius and Noble Roger Eason. Work on the three drillships will be done sequentially at BrasFels between 1Q 2011 and 2H 2013.
Transocean has named its newbuild enterprise class drillship Discoverer Luanda, constructed by DSME in Korea. The 40,000ft drilling and 10,000ft depth capable vessel is the fourth of five such units to be built by the yard. The rig will operate in Angola for BP.
Emas Offshore Construction & Production has placed an order with Keppel Shipyard for conversion of a Suezmax tanker into an FPSO unit able to produce up to 50,000b/d and store 680,000 barrels. Upon completion in 1Q 2011 the vessel will be leased to Premier Oil Vietnam Offshore for development of the Chim Sao field, offshore southeastern Vietnam.
Construction/pipelay
Acergy is having the recently acquired Borealis, a DP3 vessel equipped with a 5000t crane formerly under construction for Nordic Heavy Lift at Sembawang Shipyard, converted by Sembawang to a heavylift pipelay vessel for worldwide deepwater operations in harsh environments. Acergy plans to install a 1000t J-Lay tower and state-of-the-art 600t S-Lay equipment. Delivery is scheduled for 1H 2012 at a total cost 'expected to be less than $500 million'.
Scottish Highlands International, a subsidiary of Coastline Maritime, has placed an order with Drydocks World Southeast Asia to build an ultra large multi-purpose offshore construction barge at the Pertama yard on Batam Island, Indonesia.
The 210m long vessel, designed by Coastline Maritime, will have a beam of 36m, sized to transit the Panama Canal following planned widening of lock gates, DP3 capability provided by seven diesel electric thrusters, a 4000t crane and accommodation for 400 crew.
NorCE Offshore has contracted Keppel Shipyard to complete the NorCE Endeavour, a 146m long 1100t ringer crane equipped derrick lay barge, undertaking the installation of equipment, furnishing an accommodation block for 284 and steel fabrication works as well as assisting in commissioning. Completion is set for later this year.
An undisclosed client is having Drydocks World Southeast Asia build a Gusto MSC NG-9000C-HPE design jackup measuring 131m by 39m, reputedly the largest of its kind to serve the wind turbine installation market, suited for operations in the North Sea.
The vessel, featuring a 6500t variable load capacity and an 800t Gusto MSC crane, is scheduled for delivery 1Q 2012 from Drydocks yard on Batam Island, Indonesia.
Greatship Global Offshore Services has taken delivery of Greatship Maya, a 94m long multi-functional platform supply/geotechnical DP2 vessel from Keppel Singmarine in Singapore, bareboat chartered to GC Rieber Shipping Asia and partner Bluestone Offshore.
The vessel, equipped with a drilling unit, is able to operate in water depths of up to 1800m and capable of performing real-time in situ tests from downhole or seabed mode as well as various geotechnical laboratory tests onboard.
BassDrill has taken possession of a newbuild tender assist drilling barge BassDrill Alpha, a Bassoe Technology design constructed by Lamprell Energy at its yard in the Jebel Ali Free Zone, Dubai, at a cost of $60 million.
Polarcus, the Dubai-based geophysical company, has had Polarcus Nadia completed by Drydocks World Dubai, the first of a series of four on order by the company. The 88m long advanced 3D seismic acquisition DP2 vessel is capable of towing up to 12 streamers, and is equipped with a diesel electric propulsion system.
PT Berlian Laju Tanker (BLT), a liquid bulk cargo transportation specialist, has entered into a memorandum of understanding with Miclyn Express Offshore regarding formation of the 50:50 joint venture PT BLT Miclyn Offshore, a provider of offshore support vessels, crew/utility vessels and barges to the offshore oil and gas industry in the Middle East, Southeast Asia, India and Australia. BLT is seeking to penetrate the Indonesian offshore support vessel market, which has an estimated current market size of $250 million. AOG
Published in AOG: 2010 / February
Sembcorp Marine
CNOOC
Australia Dominates China's LNG Supply
First ANS Cargo in One Year on Way to China
Sabah-Sarawak Gas Pipeline Shit for Maintenance
Natural Gas Consumption Up 10% in China
Oil Falls Near 2% as U.S.-China Trade War Intensifies
Oil Prices Fall After Trump's Tariff Threat Against China
Novatek Sell 20% Stake in Arctic LNG 2 to China
Halliburton Reports Activity Uptick

redpajama_set_name: RedPajamaCommonCrawl


text:
HomeOffice of the SpokespersonPress Releases...Special Representative for Afghanistan West's Travel to Japan, India, United Arab Emirates
Special Representative for Afghanistan West's Travel to Japan, India, United Arab Emirates
Special Representative for Afghanistan Thomas West will travel to Japan, India, and the United Arab Emirates December 1-8. Special Representative West will consult with partners and Afghans regarding the humanitarian and economic crises in Afghanistan, protection of Afghans' rights, and shared security concerns. Special Representative West will also engage with the Afghan diaspora, including human rights, business, political, and media leaders on how to address these challenges.
Afghanistan Bureau of East Asian and Pacific Affairs Bureau of Near Eastern Affairs Bureau of South and Central Asian Affairs Economic Affairs Humanitarian Aid India Japan Office of the Spokesperson Security
Religious Freedom Designations
Ninth Meeting of the Law Enforcement Coordination Group Focused on Countering Hizballah's Terrorist Activities
U.S. Department of State and U.S. Agency for International Development FY 2023 Budget Request


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text:
/ Giorgio Moroder
/ Déjà vu
Preview Déjà vu
Giorgio Moroder Music LCC
7digital What we said: Aside from generating a wedding disco classic, Daft Punk's Random Access Memories will ultimately be remembered for reviving public interest in two of the world's most revered producers: Pharrell Williams and Giorgio Moroder. Two years on, the former is, once again, one of the biggest pop stars on the planet, and 75-year-old Moroder? Well, he's not quite there yet, but he has just shared his first studio album in 30 years. Featuring guest vocals from Kelis, Sia, Charli XCX, Britney Spears and Kylie, Déjà Vu makes for a fun second act to the disco innovator's groundbreaking career.
4 U with Love
74 Is the New 24
Tom's Diner
I Do This for You
La Disco
℗ 2015 Giorgio Moroder Music LCC under exclusive license to Sony Music Entertainment Sweden AB/RCA Records
© 2015 Giorgio Moroder Music LCC under exclusive license to Sony Music Entertainment Sweden AB/RCA Records
Also by Giorgio Moroder
Preview Club Remixes Selection Two
Club Remixes Selection Two Giorgio Moroder 2018
Preview Enne Remixes
Enne Remixes Giorgio Moroder 2018
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Club Remixes Selection One Giorgio Moroder 2018
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The Chase Giorgio Moroder 2016 From $2.49
Preview Oh, Yeah?
Oh, Yeah? Jan Hammer 1976
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In Full Effect Mantronix 1988
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text:
Epigenetics in Cancer: Translational Medicine Approaches
The New York Academy of Sciences
Epigenetics continues to be a burgeoning area for therapeutic intervention in oncology. This conference will bring together experts from both academia and industry to further explore epigenetic susceptibilities in cancer through the identification of novel targets and translational medicine approaches to define biomarkers, resistance mechanisms and clinical combination strategies.
Registration Pricing
Member (Student / Postdoc / Resident / Fellow) $25
Nonmember (Academia) $105
Nonmember (Corporate) $160
Nonmember (Non-profit) $105
Nonmember (Student / Postdoc / Resident / Fellow) $70
* Presentation titles and times are subject to change.
Registration and Continental Breakfast
Welcome and Opening Remarks
Sonya Dougal, PhD, The New York Academy of Sciences
Fiona Mack, PhD, Roche
Single-Molecule and Single-Cell Epigenetics on Earth and in Space
Chris Mason, PhD, Weill Cornell Medical College
Session 1: Insights from Mechanism Based Studies of Cancer Epigenetics
LSD1 as a Candidate Therapeutic Target in Acute Myeloid Leukaemia
Tim Somervaille, PhD, FRCP, FRCPath, Cancer Research UK Manchester Institute
Networking Coffee Break
3D Chromasomal Topology, Stem Cell Differentiation and Initiation of Blood Cancer
Iannis Aifantis, PhD, New York University School of Medicine
Epigenetic Regulations of Melanoma Drug Resistance
Emily Bernstein, PhD, Icahn School of Medicine at Mount Sinai
Data Blitz Presentations
Somatic Cancer Mutation Y4884C in Mixed Lineage Leukemia 3 (MLL3) Histone Methyltransferase Changes Substrate Specificity
Ashley J. Canning, BS, SUNY Upstate Medical University
HoxA7 is Essential for Glioma Stem Cell Survival and Tumorigenicity
Sheila R. Alcantara Llaguno, Memorial Sloan Kettering Cancer Center
Epigenome Remodeling by Cancer-associated Oncohistone Mutations
Chao Lu, PhD, The Rockefeller University
Networking Lunch Break
Session II: Translating Epigenetics to the Clinic: Biomarker and Therapeutic Insights
Epigenetic Targets in Triple Negative Breast Cancer
Kornelia Polyak, MD, PhD, Dana-Farber Cancer Institute & Harvard Medical School
Deciphering the Heterogeneous Epigenome of Acute Myeloid Leukemia
Sheng Li, PhD, The Jackson Laboratory for Genomic Medicine
Role of Mutations in Epigenetic Regulators in Pathogenesis of Myeloid Malignancies
Ross Levine, MD, Memorial Sloan Kettering Cancer Center
Targeting Epigenetic Machinery in Cancer
Ryan Kruger, PhD, GlaxoSmithKline
Considerations for Rational Combination Regimens with Epigenetic Agents
Jorge F. DiMartino, Celgene
F100 Poster Prize Presentation and Closing Remarks
Gwen Nichols, MD, Roche Translational Clinical Research Center
Networking Reception
Ross L. Levine, MD
Fiona Mack, PhD
Dr. Fiona Mack is a Director of External Innovation located at Roche Innovation Center NY. In her current role she supports the assessment of external opportunities that complement Roche's oncology portfolio. In addition to these efforts, Fiona is also the Pre-Clinical Development Lead for RO7501790, the Roche-Oryzon LSD1 inhibitor currently in clinical development. Prior to joining Roche, Fiona was a Principal Research Scientist at Pfizer Oncology. There she was responsible for the evaluation and early development of novel platform technologies, including anti-sense therapeutics, T-cell engaging bi-specific antibodies and antibody drug conjugates. Fiona received her PhD in cell and molecular biology from the University of Pennsylvania where she investigated the role of hypoxic signaling in embryonic and cancer development.
Christopher E. Mason, PhD
Weill Cornell Medical College
Christopher Mason completed his dual BS in Genetics and Biochemistry (2001) from University of Wisconsin-Madison, his PhD in Genetics (2006) from Yale University, and then completed his dual post-doctoral training as a post-doc (2009) at Yale Medical School in genetics and a post-doctoral Fellow of Genomics, Ethics, and Law at Yale Law School. He is currently an Associate Professor at Weill Cornell Medicine, with appointments at the Tri-Institutional Program on Computational Biology and Medicine between Cornell, Memorial Sloan-Kettering Cancer Center and Rockefeller University, the Sandra and Edward Meyer Cancer Center, and the Feil Family Brain and Mind Research Institute.
The Mason laboratory develops and deploys new biochemical and computational methods in functional genomics to elucidate the genetic basis of human disease and human physiology. We create and explore novel techniques in next-generation sequencing and algorithms for: tumor evolution, genome evolution, DNA and RNA modifications, and genome/epigenome engineering. We also work closely with NIST/FDA to build international standards for these methods, to ensure clinical-quality genome measurements/editing. We also work with NASA to build integrated molecular portraits of genomes, epigenomes, transcriptomes, and metagenomes for astronauts, which help establish the molecular foundations and genetic defenses for enabling long-term human space travel.
He has won the NIH's Transformative R01 Award, the Pershing Square Sohn Cancer Research Alliance Young Investigator award, the Hirschl-Weill-Caulier Career Scientist Award, the Vallee Foundation Young Investigator Award, the CDC Honor Award for Standardization of Clinical Testing, and the WorldQuant Foundation Research Scholar Award. He was named as one of the "Brilliant Ten" Scientists by Popular Science, featured as a TEDMED speaker, and called "The Genius of Genetics" by 92Y. He has more than 125 peer-reviewed papers that have been featured on the covers of Nature, Science, Nature Biotechnology, Nature Microbiology, Neuron, and Genome Biology and Evolution, as well as cited by the U.S. District Court and U.S. Supreme Court. His work has also appeared on the covers of the Wall Street Journal, TIME, LA Times, New York Times, and across many media (ABC, NBC, CBC, CBS, Fox, CNN, PBS, NASA, NatGeo). He has co-founded three biotechnology start-up companies (Genome Liberty, Biotia, and Molecular Logic) and serves as an advisor to many others. He lives with his daughter and wife in Brooklyn, New York.
Gwen Nichols, MD
Dr. Nichols is the Group Head for Molecularly Targeted Therapeutics and the Site Head for Oncology Translational Medicine at the Roche Innovation Center in New York. She received her MD with Honors from the State University of New York. She trained in internal medicine at the University of Chicago, and did her hematology–oncology fellowship at Memorial Sloan Kettering Cancer Center where she was chosen as Chief Fellow. She did post-doctoral research at MSKCC in Molecular Oncology and was an attending physician on the Leukemia Service before being recruited to Columbia University as Director of the Hematologic Malignancies Program. At Columbia she was a PI on numerous clinical trials, had an active laboratory doing translational research in hematologic malignancies, and was an Advisory Dean of Students. She served on the SWOG Leukemia Committee, on the Education Committee of ASCO, and continues to be on the Scientific Advisory Committee for the International Waldenstrom's Macroglobulinemia Foundation. Dr. Nichols was chosen "Physician of the Year" at Columbia, and received the Humanism in Medicine Award. Since joining the Roche early development team in 2007, she has been the clinical lead and Translational Medicine Leader for the MDM2 franchise. In her current role she supports several Roche programs for epigenetic modifiers.
Dominique Verhelle PhD, MBA
Third Rock Ventures
Dominique Verhelle is a strategic advisor at Third Rock Ventures. She is currently working on developing the strategy plan for a new company focusing on developing epigenetic therapies for Rare Diseases. Dominique has 21 years of experience in research focusing mainly on oncology and epigenetics. Her passion for epigenetic research started in 1999 in the laboratory of Christopher Glass at UCSD where she was Post-Doctoral fellow. She investigated the molecular mechanisms by which genes were activated or repressed during the differentiation and activation of hematopoietic cells. In 2003, she joined Celgene and applied in an industry setting her newly skill set to study the mechanism of action of Revlimid and Thalidomid and led the epigenetic effort in oncology. In 2012, she decided to pursue her passion for discovering epigenetic therapies in accepting the position of director of epigenetic in the Oncology Research Unit at Pfizer. For 3 years and a half, she led a pipeline of projects related to writers, erasers and readers for oncology purpose. Dominique relocated to Boston in October 2015 to take a new challenge: Apply epigenetic knowledge acquired from cancer research to develop new therapies for unmet medical needs in the rare diseases arena.
Dominique holds a PhD in Life Sciences from the University of Nice Sophia Antipolis, France and earned an MBA from the Rady School of Management, San Diego.
Sonya Dougal, PhD
Caitlin McOmish, PhD
Iannis Aifantis, PhD
NYU School of Medicine
Widely known for his expertise in the fields of hematopoiesis and acute leukemia, Dr. Aifantis is a Professor and the Chair of the Department of Pathology at NYU School of Medicine. Dr. Aifantis attended the University of Crete in Greece, earned his PhD from the University of Paris V, Rene Descartes and completed his postdoctoral training at Harvard University, Dana Farber Cancer Institute. He started his independent career at University of Chicago in 2013 and joined NYU in 2006. Throughout his career, he earned many prestigious honors including the 2010 Vilcek Award for Creative Promise and the 2011 McCulloch & Till Award from the International Society for Hematology and Stem Cell Biology. Moreover, in 2009, he was selected as an Early Career Scientist by the Howard Hughes Medical Institute (HHMI). He is one of the leaders of the fields of hematopoiesis and leukemia, with diverse focus areas that include the study of protein stability, epigenetic regulation and tumor microenvironment. His lab was instrumental in the understanding of the molecular mechanisms of initiation and progression of both acute lymphoid and myeloid leukemia.
Emily Bernstein, PhD
Dr. Bernstein is an Associate Professor of Oncological Sciences and Dermatology at Mount Sinai School of Medicine in New York City. She performed her thesis research in the laboratory of Dr. Gregory Hannon at Cold Spring Harbor Laboratory with a PhD from Stony Brook University. Dr. Bernstein completed her postdoctoral studies with Dr. David Allis at The Rockefeller University. She has made important scientific contributions to various areas of biology during her career, including understanding the mechanisms underlying RNA interference and chromatin regulation, and more recently, how the latter can impact on disease. Her laboratory studies epigenetic mechanisms underlying stem cell biology and reprogramming, and cancer initiation and progression with a focus on malignant melanoma.
Jorge F. DiMartino, MD, PhD
Jorge DiMartino MD, PhD is Vice President, Translational Development Oncology at Celgene in San Francisco. He joined Celgene in 2011 and has been leading a number of early stage oncology clinical programs as well as directing the Translational Research Laboratories at the Celgene San Francisco site. Jorge is the Head of the Epigenetics Thematic Center of Excellence, a fully integrated unit driving Drug Discovery through Clinical Proof of Concept efforts around epigenetic targets in cancer and inflammation. He also plays a key role in a number of external collaborations including Oncomed, Epizyme, Agios and Forma.
Prior to joining Celgene, Jorge was a Group Medical Director at Genentech in the Oncology Exploratory Clinical Development group. At Genentech, he led the early clinical development of the Hedgehog Pathway inhibitor, vismodegib, and managed a group of Medical Directors working on a diverse array of targeted small molecules as well as naked and armed antibodies from Late Stage Discovery through Phase II.
Jorge received his PhD in Immunology from Cornell University Graduate School of Medical Sciences, and his MD from University of California San Diego. He completed a residency in Pediatrics and a fellowship in Pediatric Hematology/Oncology, both at Stanford University School of Medicine where continues to see patients in the pediatric oncology as a member of the Adjunct Clinical Faculty.
Ryan Kruger, PhD
Ryan Kruger graduated with his PhD in Pharmacology from the University of Pennsylvania in 2003 where he studied the enzymes responsible for attaching virulence factors to cell walls of bacteria. From there he went on to a postdoctoral fellowship with Chris Walsh at Harvard Medical School studying the enzymes involved in non-ribosomal peptide synthesis of natural product bacterial cell wall inhibitors. In 2005, Ryan joined GlaxoSmithKline Pharmaceuticals where he started in an enzymology group supporting the Oncology therapeutic area. In 2008 Ryan moved to the Biology Department within the Cancer Epigenetics Discovery Performance Unit, where he became Head of Biology in 2014 leading a group of 45 scientists tasked with bringing forward therapeutics targeting epigenetic machinery for the treatment of cancer. In addition, Ryan is the Early Development Leader for GSK2879552, GSK's LSD1 inhibitor currently in clinical development.
Sheng Li, PhD
Jackson Laboratory for Genome Medicine
Dr. Sheng Li is an Assistant Professor of Computational Biology at Jackson Laboratory for Genome Medicine. She received her PhD in computational biology from Cornell University, Weill Graduate School of Biomedical Sciences and Institute of Computational Biomedicine. She has published a suite of comparisons of all current RNA-sequencing methods and technologies. She also developed a series of open source, computational methods and software for DNA methylation sequencing data analysis. Applying these next generation sequencing standards and software to cancer studies, she discovered novel oncogenic driver fusion genes and also developed quantitative matrices to define tumor epigenetic evolution.
Kornelia Polyak, MD, PhD
Dana Farber Cancer Institute, Harvard Medical School
Kornelia Polyak, MD, PhD, is a Professor of Medicine at Dana-Farber Cancer Institute, Harvard Medical School and is an internationally recognized leader of the breast cancer field. Research in Dr. Polyak's laboratory is dedicated to the molecular analysis of human breast cancer with the goal improving the clinical management of breast cancer patients. Her lab has devoted much effort to develop new ways to study tumors as a whole and to apply interdisciplinary approaches. Using these methods Dr. Polyak's lab has been at the forefront of studies analyzing purified cell populations from normal and neoplastic human breast tissue at genomic scale and in situ at single cell level and to apply mathematical and ecological models for the better understanding of breast tumor evolution. She has also been successful with the clinical translation of her findings including the testing of efficacy of JAK and BET bromodomain inhibitors for the treatment of triple negative breast cancer in clinical trials. Dr. Polyak have received numerous awards including the Paul Marks Prize for Cancer Research in 2011 and the 2012 AACR Outstanding Investigator Award for Breast Cancer Research. She is also a 2015 recipient of the NCI Outstanding Investigator award.
Tim Somervaille PhD, FRCP, FRCPath
Tim Somervaille is Senior Group Leader at the Cancer Research UK Manchester Institute where he leads the Leukaemia Biology Laboratory. He is also Honorary Consultant in Haematology at The Christie NHS Foundation Trust. His scientific and clinical research interest is in myeloid cancer, including acute myeloid leukaemia and the myeloproliferative disorders. Tim's medical training was at Imperial College London and University College London. His scientific training was at University College London and Stanford University.
Promotional Partners
Alexandria Center for Life Science
EpiGenie
Genome Technology Center of the NYU School of Medicine
Christopher Mason, PhD, Weill Cornell Medicine
Several new technologies enable high-resolution characterization of single cells and populations of cells, such as patients' response to chemotherapy and leukemia patients as they evolve at epigenetic and genetic layers. Here, we describe new methods to characterize modified bases of DNA (epigenomes) and RNA (epitranscriptomes) with single-molecule and enrichment-based methods, and their impact on tracing clinical dynamics during care. We also show how portable DNA sequencing on nanopore-based, single-molecule sensors can enable rapid diagnostics for epigenetics and we also present data from the first-ever DNA sequencing and epigenetics experiments in microgravity and in space. These results show the promise of novel technologies in epigenetics, unique measures of clinical responses for cancer patients, and emerging applications for long-term monitoring of human health and cellular states in remote areas.
The assumption has been that pharmacological inhibitors of LSD1 target the enzyme's histone demethylase activity to induce differentiation in acute myeloid leukemia (AML). However, we observed that drug-induced changes in transcription preceded changes in histone methylation modifications targeted by LSD1 and that AML cell proliferation did not require the catalytic activity of LSD1. Instead, concomitant with up-regulation of a myeloid differentiation program, a tranylcypromine-derivative inhibitor induced physical separation of LSD1 from the transcription factor GFI1, and more generally from chromatin. Physical separation of GFI1 from LSD1 was required for drug-induced differentiation. Evaluation of genome wide histone acetylation reveals that enhancers bound and repressed by GFI1 are activated following treatment of cells with LSD1 inhibitors. Thus, pharmacological inhibition of LSD1 promotes differentiation by disabling the activity of a key myeloid transcription factors, through abrogation of protein:protein interactions rather than blockade of histone demethylase activity and leading to activation of GFI1-bound enhancers.
Iannis Aifantis, PhD, Department of Pathology and Perlmutter Cancer Center, NYU School of Medicine
Acute myeloid leukemia (AML) is the most common adult leukemia characterized by excessive proliferation of abnormal hematopoietic stem cells (HSC) and myeloid progenitors. AML continues to have a dismal survival rate amongst all subtypes of leukemia (<50% five-year overall survival rate), which can largely be attributed to limited advances in treatment regimens that, for the last decades, have relied on the use of two non-targeted cytotoxic drugs: cytarabine and anthracycline. Large-scale sequencing efforts have shed new light on genetic and epigenetic determinants of AML. Interestingly, these studies identified a frequent co-occurrence of somatic mutation between genes encoding cohesin complex subunits (such as STAG2, SMC1A, RAD21 and SMC3) and well-characterized AML oncogenic triggers, such as FLT3-ITD, TET2, and NPM1. Our recent work has demonstrated an important role for the cohesin complex in normal stem/progenitor self-renewal and differentiation, gene regulation, and suppression of myeloproliferative neoplasms and AML, despite the precise mechanisms underlying these functions remaining poorly understood. It is believed that cohesin may suppress tumor formation by regulating chromatin looping at loci critical for self-renewal and myeloid progenitor differentiation. Utilizing established models of murine and human AML, this presentation focuses on the molecular mechanisms of cohesin-dependent myeloid tumor-suppression, with an emphasis on proposing novel treatment approaches that can exploit these functions. Overall, we focus on the idea that DNA looping and thus alteration of the 3D chromosomal topology can influence hematopoietic stem cell homeostasis, differentiation and transformation leading to the initiation of hematopoietic malignancy. Cohesin mutations is one mechanism to achieve that but is not the only one as mutations on other proteins/genes involved in 3D topological organization (CTCF, MEDIATOR etc) have also been reported in a number of blood tumors.
Epigenetic Regulation of Melanoma Drug Resistance
Cutaneous melanoma is a highly aggressive skin cancer and one of the most challenging cancers in its therapeutic management. Emerging studies demonstrate that cancer is a result of a concerted action of genetic and epigenetic alterations. Surprisingly, our understanding of the 'epigenetic landscape' of melanoma remains poorly understood. We have shown a critical role for histone variants of the H2A family in regulating melanoma pathogenesis. For example, macroH2A acts as a barrier to melanoma growth and metastasis (Kapoor et al., Nature 2010), and H2A.Z.2 promotes melanoma growth by positively regulating transcription of E2F target genes (Vardabasso et al., Molecular Cell 2015). Studies will be presented of our ongoing efforts to identify key epigenetic players in melanoma progression and drug resistance to MAPK signaling inhibitors. In particular, we have recently identified novel chromatin modifiers that play a key role in promoting resistance to the standard of care combination of Dabrafenib+Trametinib targeted therapy for BRAFV600E-mutant melanoma.
Coauthors: Thomas Strub, Flavia Ghiraldini, Saul Carcamo, Aleksandra Wroblewska, Brian Brown, Man Li, Steven Chen, Bin Zheng, and Kaitlyn Fragogiannis, Icahn School of Medicine at Mount Sinai; Stuart Gallagher and Peter Hersey, Royal North Shore Hospital, University of Sydney.
Role of Mutations and Epigenetic Regulators in Pathogenesis of Myeloid Malignancies
Clinical, cytogenetic, and gene-based studies have been used to inform biology and improve prognostication for patients with acute myeloid leukemia (AML), myelodysplasia (MDS), and myeloroliferative neoplasms (MPN). Most recently, a series of candidate gene and whole genome studies have identified recurrent somatic mutations in AML patients including TET2, ASXL1, DNMT3A, and cohesin complex mutations. Moreover, these mutations can be used to improve risk stratification in AML independent of established clinical parameters. Integrating mutational data with dose-intensity revealed that high-dose daunorubicin improved survival in patients with DNMT3A/NPM1 mutations or MLL translocations relative to treatment with standard dose daunorubicin, but not in patients wild-type for these alterations. These data provide important clinical implications of genetic alterations in AML by delineating mutation combination genotypes that predict outcome in AML and improve AML risk stratification. Of biologic importance, the TET family of proteins have been shown to place a hydroxyl mark on methylated DNA and lead to DNA demethylation. We and others have found that TET2/IDH mutations leads to loss of DNA hydroxymethylation and a hypermethylation phenotype in leukemia patients. In addition, in vitro and in vivo studies show that TET2 loss or neomorphic IDH1/2 mutations leads to impaired hematopoietic differentiation, increased stem cell self-renewal, and myeloid transformation in vivo. We have also investigated the role of mutant DNMT3A in AML pathogenesis, and shown that these mutations cooperate with other disease alleles to induce leukemic transformation and to confer chemoresistance due to impaired DNA damage sensing. We will present novel data showing how these mutations coopt the epigenetic state of hematopoietic stem/progenitor cells in order to contribute to transformation and that these mutations have biologic and prognostic relevance.
Ryan Kruger, PhD, Cancer Epigenetics DPU, GlaxoSmithKline
Epigenetic dysregulation has emerged as an important mechanism in cancer. Alterations in epigenetic machinery have become a major focus for new targeted therapies. The current presentation describes the biological activity of a potent, selective, orally bioavailable, reversible inhibitor of Protein Arginine Methyltransferase 5 (PRMT5). Inhibition of PRMT5 results in changes in levels of symmetrically dimethylated arginine residues on a variety of proteins including members of the spliceosome. This results in changes in RNA splicing of a large number of transcripts including MDM4. PRMT5 inhibition causes an isoform switch of MDM4 resulting in a shorter form of the protein that is no longer able to downregulate p53. This in turn leads to an upregulation of the p53 pathway and ultimately leads to an antiproliferative effect in cancer cell lines suggesting PRMT5 inhibition could be a novel strategy to treat a variety of cancers.
250 Greenwich Street, 40th floor
Directions to the Academy
Hotels Near 7 World Trade Center
Recommended partner hotel
Club Quarters, World Trade Center
The New York Academy of Sciences is a member of the Club Quarters network, which offers significant savings on hotel reservations to member organizations. Located opposite Memorial Plaza on the south side of the World Trade Center, Club Quarters, World Trade Center is just a short walk to the Academy.
Use Club Quarters Reservation Password NYAS to reserve your discounted accommodations online.
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Millenium Hilton
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Ritz-Carlton New York, Battery Park


http://kinman.com/model-products.php?pid=2&products=Humbucker&modelid=39&model=P90-Bucker&group= https://www.facebook.com/BuitenhuisCustomGuitars/?fref=ts http://www.fractalaudio.com http://axechange.fractalaudio.com/detail.php?preset=4196 https://reverb.com/marketplace?query=kinman+p90+buckers+zero-hum+pickups&_aid=kingman From the Kinman website: "At last, Seth Lovers brief has been fulfilled 57 years after the event - a humbucker that sounds like Gibson intended it to sound, like a P-90. This is one hell of a humbucker. Actually, a good name would be the "Humbucker From Heaven" because its lush sonic purity, gorgeous rich tone, outstanding clarity and inspirational dynamics is breathtaking to experience. If you are chasing better clarity and note definition from the low wounds our regular humbuckers are pretty darn good but the P90-Bucker represents a quantum leap into the superlative. That's because single coils 'own' clarity and note definition on the low wound strings and the P90-Bucker has a genuine, 100% authentic single coil sound. Introduced August '14. When Gibson's President Ted McCarty told Seth Lover to silence the P-90 in 1955 I took that to mean keep the P-90 sound and get rid of the hum. Well Seth got rid of the hum (almost) but the sound of his humbucker was nothing like a P-90. Gone were the expressive whack attack and the piano tones of the low wound strings. Gibson sat on the pickup for 2 years for that reason and only released it in 1957 under pressure in response to Gretsch's silent Filtertron pickup. Meanwhile a whole generation of guitar players has grown up not experiencing the wonderful sonic attributes of a gorgeous P-90. They don't know what it means to have expressive whack attack and piano tones coming from the low wound strings. That's because the P-90 was relegated to the back burner due to the massive amount of 60Hz mains hum it produces and it died a death at the hands of Gibson's marketing team and Seth's humbucker. Some 57 years later in 2013 and Chris Kinman discovers the obscure Law of Electrical Physics that prevents humbuckers from sounding anything like a P-90, especially on the low wound strings. This Law of Electrical Physics is relatively unknown since one of the few places it operates is in the side-by-side coil arrangement of a humbucker. From an understanding of the actual problem Kinman devised a solution using our recently Patented technology to allow the coils to produce a more natural string sound free from that destructive Law of Electrical Physics in the coils. The revolutionary P90-Bucker is the result and gorgeous, transparent, lush piano tones delivered with a highly expressive whack attack is the sound it produces."


Secondary or minor characters - such fun!
I was thinking yesterday about the role secondary or minor characters play in stories and how much fun some of them are.
Pride and Prejudice has all those sisters and relatives for example. Where would the story be without Lydia? Little Women well yes it is Jo's story but imagine it without Beth or Amy. It just doesn't work does it?
I love writing minor characters who come in with their energy and opinions and turn people's lives upside down.
In Mr Right and Other Mongrels Justin (who is very loosely based on a wonderful friend of mine - just by way of personality) is one of my favourite characters by far. I also adore Teddy's parents Joyce and Bob. I named them after a friend of mine's equally lovely parents (that's the full extent of the resemblance as, for example my friend, and her whole family are American).
Main characters have to sustain a whole story but minor characters , who of course have their own stories off page, can be as outrageous or gentle as you please and unlike the prtagonists you don't need to keep throwing trouble at them.
So today's question is...who are some of your favourite secondary or minor characters in fiction?


At least 15 million people roughly the population of Beijing may not be able to find jobs in Chinese cities next year, when the economy is expected to grow at below 10 per cent, according to government think-tanks.
"We anticipate that employment pressure will remain high in 2007, when 25 million urban residents will be seeking jobs, with only 10 million vacancies available," said Yang Yiyong, deputy chief of the Economic Research Institute under the National Development and Reform Commission.
Adding to the unemployed, including laid-off workers, urban job markets will see at least 12 million new job-seekers next year, he said in the "2007 Analysis and Forecast on China's Economy," an annual report published by the Social Sciences Academic Press yesterday.
The urban registered unemployment rate stood at 4.2 per cent last year. No figure is immediately available for this year, but an official tally shows that 9.32 million jobs have been created in the first three quarters, surpassing the target of 9 million for the full year.
To ease the employment strain, the country would have to cap urban unemployment below 4.6 per cent, and vigorously expand the service industries, while funding re-employment efforts, Yang told China Daily yesterday.
About half of next year's 12 million new job-seekers would be college and vocational school graduates, Yang said.
The Ministry of Education said last week that pressure on the job market for university graduates would "obviously be grave" next year, when a record number of 4.95 million 820,000 more than the year before would leave campuses.
In rural areas, there are at least 120 million surplus labourers, who are seeking work in non-farming sectors. They are also migrating to the cities, further straining the supply-demand situation there, Yang said.
"The country's State-owned companies have slowed the pace in laying off workers, but at least 1 million workers downsized earlier have yet to find jobs, while more than 3.6 million lay-offs due to bankruptcy and closures would join the queue in the coming three years," he said.
To bolster employment, Yang's institute proposed that in addition to creating 9 million jobs next year, central and local finances should earmark at least 40 billion yuan (US$5.1 billion) to fund re-employment, including subsidizing the training of laid-off and migrant rural workers.
This year, the central budget has allocated 25.1 billion yuan (US$3.2 billion) to subsidize re-employment, an increase of 4.2 billion yuan (US$538 million) from the previous year.
Fan Jianping, director of the Economic Forecast Department of the State Information Centre, yesterday said the country should focus on developing the services sector and other industries that would spur consumption.
Fan said his research team believed that the odds are high China's economy would grow at 9.5 per cent next year.
The country posted gross domestic product (GDP) growth of 10.7 per cent year-on-year in the first three quarters, according to the National Bureau of Statistics.
On average, many Chinese economists and several world organizations predict China's economy would grow at 9.6 per cent in 2007. Some, however, put the rate slightly above 10 per cent.
"Compared with a faster growth rate, it is an optimized growth model that really matters when it comes to employment," Fan told China Daily.
The shift in the growth model from exports and investment to consumption would help create more jobs and bring more tangible benefits to residents, he said.
The anticipated slowdown in fixed asset investment next year would contribute to the slightly slower economic growth, according to the "2007 Analysis and Forecast on China's Economy."
The report said fixed asset investment would increase by 20 per cent next year, compared with the 26 per cent growth rate estimated for this year.


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Educate & Inspire: Granada
Home > Blog > Educate & Inspire: Granada
Is it that time of year again? Burdened with the task of planning a school trip that's both academically rewarding, but enjoyable and exciting for students? Finding a place with this perfect balance can turn into a day spent drowning in brochures and search engine results, desperately wishing for one to fall into your lap.
Well, that's our cue. Luckily for you, here at Adaptable Travel, we've volunteered ourselves to sift through the best and worst to bring you our favourite reasons to visit Granada. Set those brochures down, close those tabs, yep… every single one, and keep reading.
A jewel in Andalusia's crown Granada treats students to a variety of memorable excursions and experiences, whatever their subject. A rich and colourful history influencing everything from architecture to culture and cuisine, it is the perfect melting pot of Mediterranean and Arabic influences waiting for your students to explore.
History and Religious Studies
Granada's history is an unusual one, shockingly different to that of its neighbours in Andalusia, and across mainland Spain. As well as its place within the rich history of mainland Spain the history of Granada is also entangled with a history of Muslim and Arab rule. Finding itself sharing historical links to other locations across Europe and Africa such as Gibraltar and Ceuta. The political and religious histories which exist along this timeline are also unique, making Granada an excellent destination for both History and Religious Studies school trips. Granada's identity is a result of a complicated and intricate history of occupation and ownership spanning from the 16th century until the late 19th century. Each chapter in this history has left a presence in present day, Granada, perfectly sealed within the architecture, museums and across the cultural identity of the city. The Mediterranean and Arabic influences are present across most activities in Granada, whether visiting a local museum or taking part in hands-on workshops. The preservation of each part of the city's history is a meaningful element of experiencing this captivating city.
Culture and Art to Engage Students
Tied to its interesting history Granada has developed a unique identity celebrating and preserving each cultural influence. In Granada, students will experience traditional Spanish experiences as well as those specific to Andalusia, the region in which it lies. Flamenco is a deep-rooted element of Spanish culture particularly in regions of Spain such as; Extremadura, Murcia and Andalusia. With the origins of Flamenco rooted in the Andalusian region of Spain, where better for students to understand the historical and cultural significance of this art form? If your students are in awe of the intricate artwork and architecture of the Alhambra, there are perfect opportunities for them to understand the significance of these elements throughout Granada. Enhance this educational trip by letting them experience this for themselves, in hands-on workshops. Explore the past and present of Andalusian culture in art museums like the "Caja Granada" or understanding the significance and methods of Arabic plaster embossing with workshop visits.
The Alhambra
Although historical in nature this trip is an extraordinary experience for students of all disciplines and interests. A UNESCO World Heritage Site, this stunning example of Arabic and Mediterranean influence was originally built as a fortress in the 10th century and is as imposing as it is intricate. First marvelling at the size of the complex itself, students will soon find themselves marvelling at the intricate and delicate artwork throughout. An interesting history of military usage and Regal habitation provides a narrative to follow as you walk the corridors of historical Granada. Whether you've got budding historians, keen artists or simply want to show your students something amazing, The Alhambra ticks all the boxes!
Food Technology and Culinary Arts
The cuisine in Granada is a wonder in its own rights. Perfectly intertwining indulgence with the ever-present influence of its history. Much like the rest of Granada, this is a perfectly crafted blend of Arabic and Mediterranean influences. Let the local cuisine take you on a culinary tour of its history; from fragrant Arabic Tagines to hearty Spanish Paellas. It's no secret that Spanish cuisine is amazing, with restaurants across the UK and abroad trying to emulate that "tapas" approach to dining. Experience the real thing in Granada! If the chance to indulge in al-fresco dining and gorgeously prepared food doesn't completely satisfy your appetite there are several experiences tailored to exploring Spanish and Andalusian cuisines. Ranging from theory-based lessons about local gastronomy to a more physical approach with food tasting and paella cooking workshops, there's something on the menu for everyone!
Granada offers something for everyone and is a truly enriching experience for students and the perfect backdrop for unforgettable memories. Our bespoke school trips can be tailored to the needs of your students, ensuring that they'll love every second of the experience.
If you would like to find out more about Granada and our other fantastic school trip destinations get in contact with us, we'd love to help you create the perfect trip!


Valve and its hardware partners first started to tease Steam Machines as far back as 2013. In September that year Valve announced it had assembled a Steam Machine prototype. Later in the year hundreds of such machines were shipped to testers and we heard that multiple Steam machines, from vendors such as Alienware, Gigabyte and Zotac, would be on sale in 2014. Unfortunately, if 2014 was the right time to launch, Valve fluffed it up for partners by delaying an official launch to 2015 due to controller designs being unsatisfactory. Partners who had readied hardware ended up having to flog their living room gaming friendly systems with Windows 8.1, or else leave them to age ungracefully with regard to modern gaming demands. It wouldn't be until November 2015 until the official launch of Steam Machines for the mainstream (people who weren't keen enough to pre-order).
Now it looks like Valve has started to 'reverse-launch' Steam Machines. Head on over to the Steam website and hover your mouse over the light blue top menu. You can see sections for Your Store, Games, Software, Hardware, Videos, and News. If you hover over the Hardware section you will see just three choices; Steam Controller, Steam Link, and HTC Vive. Steam Machines have seemingly been banished.
The above doesn't mean that the Steam Machine pages have been deleted yet. You can still search for 'Steam Machine' via the on page facility and up pop suggestions for the Alienware, Materiel.net, and Scan 3XS ST Steam Machines (here in the UK). Also the category page still exists with all the available Steam Machines briefly outlined upon it.
Understandably, there is no official 'reverse-launch' or failure announcement from Valve. The imagined hardware sales boost for Valve, and the related boost for Linux gaming, just never came. It is hard to know the precise root cause of the failure of Steam Machines. Perhaps it was the repeated delays, the price/performance of the machines, the OS/software, or even Valve's own Steam Link hardware making a dedicated living room gaming PC unnecessary.


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Guide to WebAssembly Languages
A wide variety of languages can be compiled to WebAssembly. Our programming language guide focuses on the top 20 programming languages. It also covers interesting programming languages as well as programming languages written specifically for WebAssembly.
The Language Matrix provides an easy reference for which languages support what features of WebAssembly. It also links to detailed pages for each programming language that Fermyon tracks.
Fermyon WebAssembly Languages does not track WebAssembly execution environments or runtimes. For example, we track ways to compile PHP to WebAssembly, but we do not track how to execute WebAssembly in a PHP program.
Help Us Stay Current
We do our best to keep the information here up to date. But with so many languages, each evolving rapidly, we're bound to miss a thing or two. If you have a correction or update, ping us on Twitter @fermyontech.
If you are interested in contributing to this guide, head on over to the GitHub repo.
Adding Your Language to the Matrix
If you are affiliated with a language project that adds WebAssembly support to a language, ping us on Twitter @fermyontech and let us know. We are particularly interested in WebAssembly-specific languages as well as WASI support for top-20 languages. When assessing new projects, we do prefer stable and complete codebases over experimental ones. However, given how young the WebAssembly world is, this is not a requirement.


In 1997, psychologist Arthur Aron and his colleagues published research on interpersonal closeness, suggesting that one questionnaire was all it took to make you fall in love.
Almost 20 years on, the questionnaire, which consists of three sets of 12 questions, is being shared globally on the web.
It takes the pair who try to answer it on a journey which unfolds home truths about themselves, but also about their partner, allowing them to get to know each other, each intimate moment and uncomfortable experience.
This deep connection, forged over less than a couple of hours, works because of vulnerability. Vulnerability is a state often associated with negative emotions, while in truth it allows or greater connection to our loved ones.
Brené Brown Ph. D, a research professor who has spent more than a decade studying vulnerability, explains this contradictory emotional state's relationship to courage, worthiness and shame.
In her 2010 TEDx Houston talk, Brown highlights how the results of her research helped her to personally embrace the benefits of expressing and accepting your vulnerable side, how we live in a world defined by vulnerability, and how by accepting this natural emotion, we can learn to become whole-hearted.


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Danbury Daily Voice serves Danbury, CT
Driver Dies After Tractor-Trailer Falls, Lands At I-684 Interchange
01/18/2023 11:30 a.m.
A person was killed after their tractor-trailer fell on I-287 westbound in Harrison by Exit 9A. Photo Credit: Google Maps street view/Pixabay via Diego Fabian Parra Pabon
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One person was killed after a tractor-trailer flipped over a guardrail on an exit ramp and landed on I-287 in Westchester County.
The accident happened on Wednesday, Jan. 18 around 10:20 a.m. when a tractor-trailer lost control while traveling on the Exit 9A ramp from I-287 to I-684 north in Harrison, fell from the roadway, and landed on the I-287 westbound lanes, according to state police.
The driver of the tractor-trailer was killed as a result of the crash, and an occupant of a vehicle that was on I-287 when the tractor-trailer fell was hospitalized. The name of the driver has not yet been released.
All westbound lanes of I-287 near Exit 9 are now closed, and the left eastbound lane is closed as well. Traffic diversions are now in place, police said.
The crash is still under investigation by authorities.
This is a developing story. Check back to Daily Voice for updates.
Click here to follow Daily Voice Danbury and receive free news updates.
Not in Danbury?


Over the last few months, Microsoft has been previewing its upcoming Office 2016 suite on a number of different platforms, including Android and iOS. Today, the company is ready to launch its next preview, this one specifically for Mac OS X.
The preview comes with Word, Excel, PowerPoint, Outlook and OneNote, so a pretty hefty amount of apps from the office suite. For the first time ever on OS X, the Office application suite now sports the familiar Ribbon UI.
You can get downloading via the download link below. Let us know how this preview runs for you. Considering this is a preview, each version will expire 60 days after it's posted, meaning the Office preview should get regular updates.


Fun waterfront home w/35ft. dock & access to shared pool and private beach!
Escape to paradise in this lovely bayfront Key Colony Beach retreat! Right by the canal with its very own 35-foot dock space and access to the local Cabana Club, this home will be the best vacation home base you ever imagined.
Set in neutral tones, this home's living room offers plush seating and tons of natural light. You'll feel right at home with access to cable and WiFi.
The completely renovated kitchen will prove perfect for chefs and non-chefs alike. With designer countertops, a dishwasher, and stainless steel appliances, it is upscale but comfortable. A large dining table nearby offers seats for up to six people while the balcony area provides additional seating. Outside on the deck is a gas grill for barbecues.
This two-bedroom, two-bathroom home sleeps up to six lucky guests. The master suite includes a queen-size bed, as does the guest bedroom. There are even laundry facilities available for your convenience.
The quaint town of Key Colony Beach offers perfect beach living for everyone. Catch a charter and go find some dolphins, or rent some scuba gear and seek out some colorful fish. Fishing is also big in these parts, so grab a rod or two and catch your dinner! Enjoy access to the local Cabana Club with a shared pool, private beach access, and a lounge/wet bar.
This charismatic home is nothing short of perfection! Book your stay today to experience it for yourself.
The house was ideal & perfect for our boating vacation!
Joseph W left a 5 star rating after their recent trip to Key Colony Beach, FL.
We recently returned from our stay! We had a wonderful time and the home was perfect for our family. We would definitely return!
Jordan S left a 5 star rating after their recent trip to Key Colony Beach, FL.
david G left a 5 star rating after their recent trip to Key Colony Beach, FL.
Matt G left a 5 star rating after their recent trip to Key Colony Beach, FL.
We have stayed here before and enjoyed the entire area. Convenient to both the upper and lower keys with many things to do on this key. The kitchen is well supplied for anything you want to cook. Great grill and back outside area with a large table for eating your grilled fish. We saw manatees in the canal behind the house! Fun place.
Great place to stay on Key Colony Beach! Very Clean, open, and so many amenities for cooking in!
Nice open floor plan with lots of big windows!
we were supposed to stay at a house a few doors down but it had plumbing issues at the last minute. Vacasa provided 2 alternatives and the one we chose was our original choice but changed to avoid stairs.
glad we had the option to rent this house after all!!...truly amazing how well the kitchen is stocked with everything you could imagine and more. Very clean and comfortable. would definitely stay here again.
This was our first time staying in a house instead of a hotel and I can honestly say we will not stay in a hotel again. Anything we could have needed was there and we had a great boat dock for our boat. The outdoor dining was a bonus. There were 6 of us and we were not crowded at all. We will definitely be coming back to this house!!!!


If there were any talents that you thought our Kardashian sisters were hiding, you might have been correct. Though only the youngest of the siblings, Kylie Jenner seems to have understood that in order to really create for yourself the proper persona, you need to add a few things to your resume that one simply would not think of otherwise. This is where the word "chef' comes into play as the young model and beauty enthusiast delves into the world of food as well and brings to us a show called Cooking with Kylie. How is that for a special treat?
Kylie Jenner seems to really be a business mogul. Learning from her older Kardashian sisters, she has managed to use the reality show about the family to her advantage, amassing a large fan base and effectively becoming a role model to many. While she has often been criticized for her behavior and decisions, she has also begun trying to create a more positive atmosphere for herself to work in, while becoming more and more the kind of person we do want our children looking up to.
While we certainly do not want them to be obsessing over their sizes, we do know that food is a necessity in life and good food only helps improve one's demeanor throughout the day. As such, a new cooking series by a young adult is terrific news, especially since she seems to be distancing herself from the rest of her family of late, while still celebrating their achievements, which can be seen from the images of her wearing a Yeezy sweatshirt.
The new project will effectively be a series of cooking shows available from her website that has been simply titled Cooking with Kylie and will be available for her fans to learn from. The debut featured Kylie with her sous chef friend, making something rather interesting and quite different from your average cooking channel show, Kylies' candied yams. Almost everything used is organic throughout, with ingredients such as maple syrup, coconut oil, cinnamon and marshmallows coming into play. Add in some orange juice, brown sugar and the yams of course and cook it all together for something really tasty it appears. The show uses text bubbles to reiterate the instructions as well, making it accessible to the hearing impaired as well.
Kylie mentions that "cooking is very therapeutic' at one point and we are inclined to agree. It certainly allows you to do something almost mindlessly after a time, allowing your thoughts to focus and new ideas to take root. Her enthusiasm is also contagious, making the show easy to watch, while it quickly becomes apparent that all that she makes is greatly appreciated by those around her. Now we would like to try some of those sometimes very unhealthy dishes. Might make us fall in love with food all over again the way it stands.


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Creating Sanctuary, An Embodied 'Drash
I spent this past Shabbat at a sisterhood retreat with the women of Temple Beth El of Aptos, California. We met at beautiful Mt. Madonna Center, a lofty retreat on a mountaintop high above Monterey Bay that Reb Zalman Schachter-Shalomi, may his memory be a blessing, used to call "Mount Shekhinah." Throughout the weekend, interludes of brilliant, warming sunlight alternated with rain and fog, giving rise to mystical ananei ha-kavod, clouds of glory, flaming pink sunsets, and even a waterfall of rainbow in the eastern sky just before Shabbat's end. My dear friend, Senior Rabbi Paula Marcus, had invited me to be a guest presenter at this, the congregation's first ever women's retreat, and specifically to bring an element of movement and creative engagement with prayer and text study to the women of her community. The Torah 'drash and kavannot below introduced our three readings from the double Torah portion of Vayak'hel/Pekudei in the Book of Exodus verses 35:1 - 40:38 on Shabbat morning.
We have arrived at this central moment in our Shabbat morning service, this moment where, week after week, we undress and address the teachings of our sacred Torah scroll, our ancient lineage. To undress is to reveal; to address is to confront, to come into relationship with, and ultimately, to re-clothe in a new way. The great and amazing thing about our tradition is that our sages always knew and modeled for us that the true Torah is not only the words scribed on a scroll or printed on a page, but the ever-emergent conversation between us and those words and all the spaces in between!
This is the process we call midrash--seeking, understanding, imagining. When I can realize that all that the Torah contains—the good, the bad, and the ugly—is also present within me—at least the potential for it—then grappling with these stories, engaging with them, draws me into a deeper, richer, and more honest appreciation of my own gifts and potentials and failings. Each time we encounter Torah in community, a healing can occur, a redress, as we support one another to realize that the wisdom the words draws forth already lives in us; it is not something we have to learn, but something that can be awakened, remembered, called forth from deep within our psyches and our body memories, and ultimately healed. We can dream it together, in just the ways that are needed for this moment, and for each of us.
So where are we in our Torah story today, this Shabbat? With the double portion of Vayak'hel/Pekudei we arrive at the end of the book of Exodus. From where the people began, many weeks ago—go with me there, now—crushed in body and spirit by enslavement in Egypt, cut off from one another and their own deepest selves, groaning in pain and so "kotzer ruakh, so short of breath and spirit, that they are unable for a long time to receive the Divine message of redemption flowing through Moses, we arrive now at this auspicious moment—picture it: liberated into the fearful wildness, the midbar, they are set to embark on a great building project designed to forge them into a community. They are invited to bring all that they have and all that they are to the creation of a Mishkan, a Tabernacle which will be a kind of portable Mt. Sinai, with its own fire, smoke, and cloud–a sacred dwelling space that is meant to draw the Divine Presence into the midst of their community, and deep into their hearts, to accompany them in all their travels.
I invite you to awaken the memory of this momentous passage in our own body-mind-heart….to stand and take some space, or sit, to breathe, perhaps to remember some time in your own life when you felt constricted, filled with the fear that congeals in us when we are subject to misused power, perhaps you felt trapped, unable to breathe. What did that feel like in your body? Move with that feeling for a moment. Find your way into a whole-body gesture that expresses that feeling of constriction, of having no space and no options.
Now gently release into a neutral place for a moment. Breathe. Remember a time when you felt empowered, when your gifts were wanted and fully received. Feel the sense of openness, of eagerness, the generous heart that awakens when your offerings, your creativity are valued, are honored. How does that feel in your body, in your mind, in your spirit? Can you move with that feeling? Can you shape your body into a gesture that expresses that openness, generosity, connectedness, creativity, enthusiasm, and love?
Now, for a moment, return to your first body gesture and practice several times the transition between that and your second gesture. Get to know the path between them. Move around the room with your gestures—when you see someone in a constricted place can you soothe them with a gesture of giving, of love? When you are in the constricted shape, can you feel and respond to the balm of others' loving offerings around you? When you're ready, you may find your way back to your seat.
Can you feel how beneath all the drama, the trauma of the Exodus journey, there lies this essential human movement, embodied day by day, moment by moment, sometimes breath by breath in our own lives, from constriction to expansion to constriction again, from connection to dejection to reconnection, from absence to presence, and then emptiness again—back and forth and back and forth? What provides some constancy, some ground for you, in the midst of all this movement?
Asu li mikdash v'shakhanti b'tokham, the Divine has spoken through Moses, so many chapters ago: "Build me a holy Sanctuary and I will dwell among them, with them, within them." Constancy. Presence. In today's parashah, we are seeing the fruits of that Divine imperative, given so many chapters ago, the minute details of its dimensions and materials and furnishings and the priestly garb reiterated four times in the Book of Exodus alone, occupying 13 of its 40 chapters. We have come to the moment to gather our resources, to contribute the materiel for this holy building project.
Sanctuary. In Torah this structure to be erected at the center of the Israelite encampment is referred to first as "mikdash," "holy space," later as "ohel moed," "tent of meeting," and finally as "mishkan," often translated as tabernacle, but literally meaning, "dwelling place." A dwelling place for Shekhinah, Divine Presence on earth, a place of safety and of celebration, of guidance, of healing, a gathering place for people, a resting place for the Divine in this world. How different is this Sanctuary from the sanctuaries we seek to create, to be, today—a space, a town, a country in which the contributions, the creative energies and enthusiasm of each inhabitant are valued and sought after to build a communal structure, a community with love, compassion, awareness, Presence at the center, like a polestar, a guiding light, ever visible? In our reading today of the building of the Mishkan, a dwelling space for Divine energies in this earthly realm, we along with the ancient Israelites, are called to re-member our worth and the worth of every person in our midst, to repurpose the hidden riches of our lives, so that we may become part of a sh'khunah, a true neighborhood (same Hebrew root), in which every soul is a valued co-creator of a holy, God-filled community that honors the resources, the creativity, and the wise heart of each of its individual members. The Mishkan project is so central in Torah because it comes to heal a broken people, to remind these newly freed slaves, and each one of us, of the need for Sanctuary at the heart of our camps, at the heart of our lives.
First Aliyah: Exodus 35:4-10
Our first Aliyah begins with Moses conveying to the people God's spiritual imperative to bring trumah for the building of the Mishkan:
קְחוּ מֵאִתְּכֶם תְּרוּמָה לַיהֹוָה כֹּל נְדִיב לִבּוֹ – "Take from your self a portion and raise it up for YHVH, every one whose heart is inspired to give." In other words, God says, "Go back to your tent, and dig up those stashes of gold, silver, copper that you just happened to bring out of Egypt, that yarn you've been meaning to knit into something cozy but never seem to get to, that old piece of fabric, that dolphin skin jacket you haven't worn for years, that old jewelry, those mirrors and bring 'em on down!" So the invitation for this aliyah is to recognize that what you've got hidden away in your closet is valuable. Not only the material items in your physical closets and garages, those things you've been meaning to take to Good Will (especially if they no longer make your heart sing) but the riches of your life experience, the painful passages you've endured, the illnesses, the heartache, the tears, your personal brushes with oppression and silencing and rejection. This is the moment to bring it forward, this portion from your self, to lift it up, and to know that what you might seem like the throwaways of your life are precious: they are gold, silver, copper, and jewels. Every hidden talent is wanted and life experience is needed for creation of the Sanctuary, a space that raises up and makes holy the whole community. Ta'amdu, ta'amdu, ta'amdu…. all who wish to make an offering of your deepest selves to build the holy communal space of our world.
Second Aliyah: Exodus 35:25-29
This next section of our text reinforces what was so strikingly evident in the last aliyah–that everyone in the community who is "wise of heart," whose heart leaps forward, is to be enlisted in this grand building project—every woman and every man. Unlike many other parts of the Torah, where only the men are counted, the Mishkan project engages both women and men, the masculine and the feminine energies together to fulfill the Divine imperative to create vibrant and beautiful sacred space. No one rejected, everyone's skill and inspiration included, regardless of gender, class, skin color—truly, the prototypical Revolutionary Love movement.
This aliyah will be to honor the women's special offerings to the Mishkan, and in particular the women's offering of their spinning. We read:
וְכָל־הַנָּשִׁים אֲשֶׁר נָשָׂא לִבָּן אֹתָנָה בְּחָכְמָה טָווּ אֶת־הָעִזִּים, "every woman whose hearts inspired them with wisdom spun the wool." These are the threads which will be woven into fabric to create the "skin" of the Mishkan, its coverings, and the elaborate garments of the high priest. You may know that the drop spindle is one of the human oldest tools, appearing somewhere the mists of pre-history, more than 7,000 years ago. With it, women spun fibers of cotton, flax, goat and sheep hairs into tough, resilient threads. Spinning was a ubiquitous activity in ancient cultures, time-consuming labor needed to produce the yarn to weave the fabrics for clothing and shelter. Everywhere women went and whatever else they were doing—walking, nursing a baby, gathering herbs, preparing food—they carried their spindles, looking like large wooden dreidls, to work bundles of raw flax and wool into yarn—perhaps the first instance of women's multi-tasking! The Israelite women, the midrash teaches, were so eager to create the threads for fabrics of the Mishkan, that they didn't even wait for the goats and sheep to be sheared, but miraculously spun the hairs into yarn while they were still on the animals!
This aliyah honors the countless generations of women—our mothers, and grandmothers, our great and great-great grandmothers—who spent their lives immersed in the constant, nearly invisible work, the melakhah, of spinning, sewing, weaving, knitting, embroidering, crocheting, quilting—not only yarns and fabrics, but families, communities, and cultures. We honor all the ways that we women gather and comb and smooth the raw materials of our own lives, and those of families, our friends, our students, and clients, patiently twisting and strengthening and integrating to create the strong, vibrant and beautiful fabrics that we call "home," "workplace," "dwelling space," "mishkan." Ta'amdu, ta'amdu, ta'amdu, all who honor and all who are the spinners and weavers of lives….
Third Aliyah: Exodus 40:33-38
Our final aliyah takes us to the very end of the book of Exodus, the culminating moment, when Moses has actually erected the Mishkan, according to Divine specifications, and with the contributions of all the people, and the anan, the cloud that has been guiding the people ever since they left Egypt, descends on the ohel moed, the outer part of the structure and " כְב֣וֹד יְהֹוָ֔ה מָלֵ֖א אֶת־הַמִּשְׁכָּן " "the Presence of Beingness (Was-Is-Will-be) fills the Mishkan, the inner precincts, the Holy of Holies. The movement of this Presence will later come to be known as Shekhinah, that aspect of Divinity that accompanies us on all our journeys, that is present in all of Creation, that is, as some mystics teach us, the material world itself. The text tells us, "When the cloud would rise up from upon the Tabernacle, then the Children of Israel would embark on all their journeyings. But if the cloud did not rise up, then they would not embark, until the day it rose up." This aliyah is for those who wish to invite a more profound level of Divine guidance into our lives, to know in our very bones, that we are not moving alone, that the love we have poured into creating and sustaining the structures, the mishkanim of our lives, is the Divine made manifest, and that we can trust its guidance to come through our intuitions and our dreams and our everyday moments, if we will but turn our eyes and our wise hearts in its direction. Ta'amdu, ta'amdu, ta'amdu, all who seek to open to receiving Spirit's Presence in all our journeyings….


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Theoretical foundations for statistical network analysis
Steiner trees in the stochastic mean-field model of distance
Ayalvadi Ganesh University of Bristol
Thursday 3rd November 2016 - 14:00 to 15:00
[SNA] Theoretical foundations for statistical network analysis
Consider the complete graph on n nodes with iid exponential weights of unit mean on the edges. A number of properties of this model have been investigated including first passage percolation, diameter, minimum spanning tree, etc. In particular, Janson showed that the typical distance between two nodes scales as (log n)/n, whereas the diameter (maximum distance between any two nodes) scales as 3(log n)/n. Bollobas et al. showed that, for any fixed k, the weight of the Steiner tree connecting k typical nodes scales as (k-1)log n/n, which recovers Janson's result for k=2. We extend this result to show that the worst case k-Steiner tree, over all choices of k nodes, has weight scaling as (2k-1)log n/n. Further, Janson derived the limiting distribution of the typical distance between two nodes. We refine the result of Bollobas et al. and present a perhaps surprising result in this direction for the typical Steiner tree which has implications for the limiting shape of the 3-Steiner tree. This is joint work with Angus Davidson and Balint Toth.


MANSFIELD -- Wally's Chicken Coop may be small but it is big on flavor in every dish.
A staple in the Mansfield/Storrs area, Wally's serves up fresh, never frozen hand-cut chicken any way you like it. In a wrap, buffalo-style or on a sandwich, the chicken is all white meat and prepared daily.
The menu is filled with choices and one of the most popular one is Puds, a deep-fried mashed potato ball and comes as a side item with the signature chicken.
"The Puds are so popular and are always made to order," said manager Rose Sorrell. "It's a cross between a french fry and a tater tot and it is pure loveliness."
The atmosphere is inviting and the staff is friendly which creates a fun place to eat and hang out near the Uconn campus.
"The people make the atmosphere and that brings everyone here," quipped loyal customer Aaron Kahn. "It is so fun here and the food just tops everything off."
Do you have a suggestion for Foodie Friday? Let us know by emailing foodiefriday@fox61.com or reach out to us on Facebook, Instagram, and Twitter - just use #FoodieFriday and #FOX61.


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ZEW Researcher Receives Social Market Economy Research Award
Heinz König Award
Dr. Laura Pohlan, a researcher in the ZEW Research Group "Market Design", received the 2020 "Forschungspreis Soziale Markwirtschaft" ("Social Market Economy Research Award") by the Roman Herzog Institute (RHI) Munich on 7 October 2020. She was awarded the third prize for her dissertation on the social consequences of unemployment and the effects of direct and indirect state measures on employment. She wrote her dissertation while still working in the ZEW Research Department "Labour Markets and Human Resources". The award ceremony was held online.
Laura Pohlan's work "Essays on Unemployment, Job Search Behavior and Policy Interventions" examines the multiple causal effects of unemployment in the context of social exclusion. She shows that the feeling of social exclusion increases with the duration of unemployment and may even continue after taking up a job. She also investigates how social policies and technological innovation influence individual behaviour in job seeking and in what way they help to reintegrate unemployed individuals into the labour market.
The Roman Herzog Institute is an interdisciplinary think tank that addresses socio-political issues relating to both the future of work and ethics in the social market economy. The award is one of the highest endowed prizes in the field of economics and social sciences.
Press Relations and Editing Market Design
Award Social market economy
PR Contact Julia Glashauser
Email Julia.Glashauser@zew.de Phone 06211235192
To the profile
Scientific Contact Dr. Laura Pohlan
Email Laura.Pohlan@zew.de
Online Communications Manager, Yvonne Bräutigam, MSc
Email yvonne.braeutigam@zew.de Phone +49 (0)621 1235-322
Shortlink: https://www.zew.de/AM7381-1


You know how you can imagine something in your minds eye but then when you actually turn your idea into reality sometimes things just don't turn out as you expected? I have had this happen to me MANY times. And one thing that really frustrates me is having to go back to the beginning and starting all over again.
Don't these stairs look amazing? Well, in Rachael's instructions, she warns of having a light hand when applying the stain. Whenever I hear instructions like, "be sure to use a light hand," I worry. This tells me that finesse is required and if I am rushed or stressed….yes, you guessed it….I'll be ripping things out and starting all over again.
I also saw online where people did not stain their bags and that they were very happy with the result. This would eliminate a step and there is no longer a " light hand" needed. But I really like the darker look. Think, think, think.
Okay, so went out to look for water based polyurethane that has stain mixed in. No luck…bummer! Plan B, what can I add to my glue/water mix to tint it? I begin throwing ideas out to my husband, the engineer. Could I mix in stain….he says that an oil based stain won't mix with my glue emulsion. Okay, how about I brew some tea and then mix it in. His response, " if there is any nutritional value, we will have bugs eating our floor". Okay, final idea, What if I add RIT dye….he say, "could work"!
So, I first mix 1 4oz bottle of elmers glue all with 1/4 cup water and 1 tsp of RIT liquid dye. It looks purple, not brown!
Okay, deep breath. The bottle said brown so I am going to keep on going. I also mixed a second batch of 4 oz glue plus 1/4 cup water (I am going to do a sample of non-dyed paper bag treatment as well). Out comes the board and time to apply the paper.
You will NEVER guess what happened overnight. The dyed half went from purple to brown! It's amazing. Take a look!
Okay, now it's time to add some polyurethane to get a better feel for how this will look in the end. I decided to just put on two coats. I placed the board on the ground and took a picture…keep your fingers crossed!
You can see where the glue was left on a bit heavier but I'm thinking I like the dye/glue mix. I may add a bit more dye to my mix as well.
As they say, an ounce of prevention is worth a pound of cure. I hate waiting for a project to be done but when it comes to faux finishes, I swear by sample boards!
Yay for the brown. There are sooo many times I should have used a sample board. In this instance I think your approach is perfect, when you get ready to go you know you'll be truly ready!!
That is going to be so pretty! I hope to have a "woman cave" of my own one day, and when I do, I'll have to remember this!
-ps for some reason when I went to respond to your post earlier when I click respond, nothing happens…still kinda new to all this but it seemed pretty self explainitory. Maybe I'm missing something?
Looks good- it should be really nice! Never used a sample board before- what a great idea. Thanks for stopping by my blog and checking out my Bolster Pillow. I am a new follower of your blog and would love it if you'd like to follow along, too!!
It might just work…I'm contemplating doing my son's room with same paper bag treatment. I'll stay tuned into you.
Oops, forgot to mention I'm now a new follower.


The compatible HP 96 (C8767WN) black ink cartridge replaces HP 96 ink cartridge and is compatible with HP Deskjet 5740, Deskjet 5740Xi, Deskjet 6520, Deskjet 6520Xi, Deskjet 6540, Deskjet 6540DT, Deskjet 6540Xi, Deskjet 6620, Deskjet 6620Xi, Deskjet 6830, Deskjet 6830V, Deskjet 6840, Deskjet 6840DT, Deskjet 6840Xi, Deskjet 6940, Deskjet 6940DT, Deskjet 9800, Deskjet 9800D, OfficeJet 7210, OfficeJet 7210V, OfficeJet 7210Xi, OfficeJet 7310, OfficeJet 7310Xi, OfficeJet 7410, OfficeJet 7410Xi, PhotoSmart 8150, PhotoSmart 8150V, PhotoSmart 8150Xi, PhotoSmart 8450, PhotoSmart 8450Xi, PhotoSmart 8750, PhotoSmart 8750GP, and PhotoSmart 8750Xi models. The product yields 860 pages at 5% coverage, 21ml capacity. Our compatible HP units come with a 100% satisfaction guarantee.
The HP PhotoSmart 8750 printer measures 10 inches X 25.3 inches X 24.1 inches and weighs about 26 pounds. Print speed for the HP PhotoSmart 8750 printer can reach up to 19 pages per minute for black and 18 pages per minute for color outputs. Paper capacity comes with 80 sheets.
There are three ink models for the HP PhotoSmart 8750 printer – C8766WN, C8767WN and C9363WN. The No. 95 tri color ink comes with 330 pages at 5% coverage or 7ml capacity. The No. 96 black ink comes with 860 pages at % coverage or 21ml capacity. The No. 97 tri color ink comes with 560 pages at 5% coverage or 14ml capacity. Users can seek for high quality re-manufactured cartridges at an affordable price to save more on printing expenses. In fact, a well made compatible cartridge should work as well as name brand counterparts. In addition, the use of compatible cartridges does not void the HP PhotoSmart 8750 printer warranty.


Our Tilly bucket bag is crafted from smooth black leather and suede that's artfully embossed in a snake-effect pattern. With handy zipped pockets and a neat drawstring top, this style is fitted with a fully adjustable shoulder strap. Wear yours day-to-night, using the fully-lined interior for all your essentials. Bag measures 26cm/10in in height, width across the middle is 28cm/11in & base width is 15cm/6in.


WASHINGTON, DC -- As the few healthy Boston Celtics who actually made the trip to Washington, DC hit the practice court at Georgetown University, two of the injured Celtics took to the practice facility floor in Brighton to test their injuries.
The good news is that there were no surprises after the Sunday night loss to the Orlando Magic where both Tatum and Smart got hit. Neither had any worsening of symptoms or any deeper injuries.
Smart's injury was more concerning for the Celtics. They're still calling it an oblique contusion and not a strain, which makes for an unclear timeline.


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Brantford Expositor
Share this Story: Achievement award for artist
Achievement award for artist
Susan Gamble
Brantford multi-media artist Shelley Niro has nabbed another high profile art award. Last week she was presented with a $30,000 achievement award from the Ontario Arts Foundation. Photo by Submitted photo
Six Nations photographer and artist Shelley Niro has received a $30,000 achievement award from the Ontario Arts Foundation.
"It's a great award," said Niro, who lives in Brantford with her husband, Chel Niro.
Achievement award for artist Back to video
"I've been holding off on buying another lens but, now, I don't have to."
Niro is a multimedia artist whose work encompasses film, photography, painting, sculpting and bead-work.
Her latest exhibit – Something Cold and Hard like Winter – is on display at Wilfrid Laurier University's Robert Langen Art Gallery in Waterloo. Her work has been exhibited across Canada the the U.S.
Last Thursday, Niro gave a lecture at Laurier's Waterloo campus, after which Alan Walker, executive director of the arts foundation, presented her with the Paul de Hueck and Norman Walford Career Achievement Award, which recognizes the work of an art photographer, classical singer or keyboard artist.
It's not the first big cash award for Niro, who won the $50,000 Scotiabank Photography Award in 2017. She has won many other Canadian and American honours.
"Any award is great and I don't care how big the prize is," Niro said. "It's about being recognized by your peers and having them say, 'This work is important and should be looked at'. It's going to make people look at my work a little more closely.
"And the money is certainly welcome."
Niro said the award process required her to update her online presence and make submissions after she was notified of her nomination last year.
Niro was born in Niagara Falls, N.Y., but grew up on Six Nations. She is known for art that explores her heritage and breaks stereotypes.
"Shelley's thoughtful observations of the landscape and our existence within it are beautifully expressed in this exhibition through her photographs and video," said Suzanne Luke, curator of the Langen gallery.
"We're thrilled to celebrate the premiere of Shelley's new video, Peacemaker's Test, in this exhibition."
Of all the media she works in, Niro said she loves photography best.
"Anyone can pick up a camera and take pictures, but when it comes down to choosing the images, framing them and matting them, it can sometimes be a bit overwhelming."
Known for her portraits – especially of family, Niro takes a turn with her new exhibit.
"This exhibit is geared toward rocks and I really enjoyed blowing them up to be big-sized photographs. Here we are in Southern Ontario and I'm trying to show rock faces as an art form instead of just something that surrounds us."
She said the exhibit includes samples of fossils that "once had their own lives going on and are now stuck."
Niro said she is busy these days "administrating" herself, fielding queries about the use of her images or seeking to arranging showings.
When things get too harried, the artist said she often turns to bead-work.
"Anyone can do bead-work," she said.
"There can be a lot of technique that goes into it but mostly it's a lot of counting. It's a good stress-reliever."
She said she gets new ideas for art all the time.
"It's just a matter of being disciplined to keep working on them."
Something Cold and Hard like Winter will be displayed until April 3 at the Langen gallery, 75 University Ave. W.
The gallery is open weekdays, 10 a.m. to 10 p.m., and weekends, noon to 10 p.m.
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In April 3, 2011, the 1 st Heilongjiang Curling Championship held it opener in Harbin Winter Sports Training Center .
Several hundred of curling lovers watched the match. In this sport event, there are 8 man's teams and 6 women's teams participating, with curlers of age 42 at the eldest and age 11 at the youngest. After the match, there will be Curling Training Courses over the whole country organized.