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Published on January 8th, 2016 | by admin
'Multilateralism Is Key'
The 2015 White Paper on Defence states that; "Ireland advocates a strong EU contribution to UN peacekeeping and crisis management. Within the framework of multilateralism and collective security and in support of international peace and security, Ireland will continue to contribute to a range of cooperative and collaborative security arrangements within the EU , the UN , the OSCE and bilaterally with other states." With this in mind, SIGNA L posed some questions to Brigadier General Murray Piggott, Military Representative at Ireland's Permanent Mission to the EU.
Can you provide an insight into what the role of the Milrep to the Irish mission to the EU actually is?
Before explaining my role, it is necessary to explain two key political and military structures in the EU which came about after the treaty of Nice in 2000 and were designed to enable the Union to fully assume its responsibilities for crisis management.
These were the Political and Security Committee (PSC) and the European Union Military Committee (EUMC).
The PSC meets at the ambassadorial level as a preparatory body for the Council of the EU. Its main functions are keeping track of the international situation, and helping to define policies within the Common Foreign and Security Policy (CFSP) including the Common Security and Defence Policy (CSDP). It prepares a coherent EU response to crises and exercises its political control and strategic direction over military and civilian CSDP missions.
The EUMC is composed of the Chiefs of Defence (CHOD) of Member States (MS), represented by their military
representatives (Milreps). It may meet at CHOD or Milrep level. The EUMC is the forum for military consultation and cooperation between the EU Member States in the field of conflict prevention and crisis management. It provides the PSC with advice and recommendations on military matters. The role of the Military Representative within the EU is to represent the Chief of Staff (COS) in accordance with policies determined by the Minister and the Government, at the EUMC and within the other official bodies of the Union in which the Milrep or his staff participate. In the EUMC, the Milrep represents Ireland's position in accordance with directions given by DFHQ having ensured that the position that is being represented has been properly 'triangulated' with the Department of Defence and the Department of Foreign Affairs and Trade. Where issues of policy (including military operational issues which may impinge on national defence policy issues) arise or are flagged in the context of the EUMC
deliberations or deliberations by its support bodies, the Milrep brings such issues to the attention of DFHQ, the PSC
ambassador and the departmental representative in order to ensure that Ireland can determine its position and influence ongoing discussions.
The Milrep is also part of the PSC Delegation in the Irish Permanent Representation to the EU. The PSC delegation is
led by an Ambassador and consists of two other personnel from DFAT, four personnel from Dept. of Defence and three other Defence Force officers, in addition to the Milrep. The PSC to ensure that Ireland's engagement in CSDP is consistent across all CSDP fora. Within the PSC delegation, the Milrep provides military advice to the PSC Ambassador, and with his staff, ensures that information pertaining to military matters within the EU are disseminated to the PSC delegation and to DFHQ.
In the light of Ireland's policy of non-alignment/neutrality, what sort of advice does the MILREP provide and on what issues, normally?
Ireland is a committed supporter of the EU's Common Foreign and Security Policy (CFSP) and its action element, the Common Security and Defence Policy. From a military perspective, my interaction generally involves CSDP issues and any advice given, comments made or points raised will be in line with any national standpoint or certainly any position that has been triangulated beforehand. The issues dealt with at the EUMC are varied and can
range from those pertaining to the initiation of operations to the development of work-plans for the EU Military Staff to the provision of military advice to the PSC on issues like the 'Hybrid Threat', such as that posed by cyber-attacks or non-state actors, for the EU's Comprehensive Approach. The EUMC generally gives advice and recommendations on the overall concept of crisis management in its military aspects; military aspects relating to political control and to the strategic direction of operations; the risk assessment of potential crises; the military dimension and implications of a crisis situation; the elaboration, assessment and review of objectives and military relations
with applicant countries, third countries and international organisations. The nature of the EU means that decisions are normally made with the consensus of the 28 member states and this is true also of the EUMC.
A practical example of the work of the EUMC is the launching of Operation EUNAVFOR MED (Op Sophia) earlier this year.
Throughout May and June, the EUMC was considering proposed EU Naval operation in the Mediterranean, which was one component of the EU's comprehensive approach to address the Migrant Crisis. Once the political guidance regarding the proposed CSDP operation was developed, the EUMCs first task was to provide military advice on this to the PSC. During the discussion that preceded the advice, all of the Member States (MS) had an opportunity to air their views or concerns regarding the feasibility of the operation and the risks involved and to shape the operation in an effort to ensure that it would achieve its objectives. The advice was then compiled, taking into consideration all of the views expressed, before being agreed by all 28 MS.
After the initial advice was accepted for this operation the EUMCs next task was to translate the political guidance into military direction. Again the views of all 28 MS were taken into consideration before the final document was given to the Operational Commander (Op Cdr). From that point onward he assumed responsibility for the planning process. While more advice was given to the PSC about other aspects of the operation the key aspects regarding the initiation and development of the operation had been accomplished.
How do DF missions such as this [Brussels] represent the organisation in terms of demonstrating capability?
This is a very different mission compared to most of the other missions where DF Officers have served. On a daily
basis officers in the Permanent Representation are working at the Political-Military Strategic level, they are not only working with Dept. of Defence and Dept. of Foreign Affairs and Trade colleagues but are also constantly interacting with civilian and military colleagues from the European External Action Service (EEAS) and from the other 27 member States on any number of different issues. These interactions are generally focused on the EUMC strategic priorities and supporting strategic actions. The essential capabilities to successfully work at this level are the ability to analyse strategic intent, to contribute to the strategic planning process and to contribute to the implementation of a comprehensive Approach in the EU. The key requirements from DF Officers are to provide military expertise with regard to all aspects of CSDP missions and operations, support long term capability development and support capability initiatives such as pooling and sharing. In any of the working groups in which we are involved, or any
of the meetings that we attend, where it is relevant, we will make contributions based on our knowledge of Ireland's general policy approach to Defence issues and our diverse operational experience, at home or on missions abroad. Irish Defence Force capability is demonstrated directly through our contributions in these fora and our ability to work for the required consensus to bring the various issues to a successful conclusion.
What level of interaction do you have with your colleagues/contemporaries from other countries, particularly EU and/or NATO countries, and how do these interactions inform your role?
In addition to EU, Ireland participates in NATO/PfP pursuant to a government decision which also authorised the deployment of a Military Representative to Ireland's NATO/PfP Liaison Office.
The Military representative to the European Union is double hatted for the purposes of this role and therefore represents the Chief of Staff in relevant NATO bodies such as the Euro-Atlantic Partnership Council (EAPC)1. In practical terms, this means that on almost a daily basis, I interact with other Milreps who are either affiliated to the EU or NATO or both and also with many Milreps of the other 21 partnership countries affiliated with the Euro-Atlantic Partnership Council. While most of our business is conducted in formal sessions, much of the spade work to
reach consensus is carried out in informal sessions. Whether we are meeting formally/informally or in smaller groupings, having built personal relationships within the Milrep community is key to being able to gain support for positions being taken by Ireland on a particular issue given the requirement to achieve consensus to bring issues to a conclusion. Also, recognising that multilateralism is key to dealing with the complex security environment that Europe faces now and will continue to face in the future, maintaining close links with other MS at the level
of Milrep may be of assistance to the DF as it implements the Defence White Paper in the coming months and years.
In light of the current security situation, has there been an increase in the demands of your role, and how?
Recent events in the Ukraine, the Middle East and North Africa certainly have focussed attention onto security and defence issues, both within Europe and around the world. This in turn will feed into the High Representative's Global Strategy on Foreign and Security Policy, which is currently being developed and which will be published in June 2016. While each member state will provide input to the document it is probable that there will be a large body of work for the EUMC after its publication. In addition, many of the Military Concepts developed by the EUMC over the past number of years will now have to be dusted down and re-examined in the light of the new security reality in
which we find ourselves. Many member states are keen to have the military voice heard at the political level and to this end the EUMC is very likely to be tasked with providing more military advice to inform the political decision making process.
Managing Our Greatest Asset →
Effective Mobility: Transport Corps At Home, Overseas →
Mission of Mercy →
'Leading A Platoon Is A Great Experience For A Young Officer' →
Coveney Vows Measures to Stem Drain of Manpower From Navy	July 20th | by admin
'A Picture That Should Be Of Concern'	February 27th | by admin
Managing Our Greatest Asset	February 27th | by admin
Defence force fathers from abroad	June 20th | by admin
RACO SDC Elects New President	March 16th | by admin
Serbian envoy claims that 'Serbs have been cleansed from Kosovo.'	March 16th | by admin
Partners/Sponsors
SIGNAL Journal is one of Europe's leading defence and security journals published on behalf of RACO (www.raco.ie) for commissioned officers in the Irish Defence Forces. It is distributed nationally and internationally through RACO's affiliation with EUROMIL to a wide number of officers in European defence forces and agencies.
Universal Media Agency
Email: talk@universalmedia.ie


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Als China Marines wurden diejenigen United States Marines bezeichnet, die im 4. US-Marineinfanterieregiment, welches in Shanghai (China) stationiert war, zwischen 1927 und 1941 gedient hatten. Das 4. US-Marineinfanterieregiment war eingesetzt um US-amerikanische Bürger und deren Eigentum während des Chinesischen Bürgerkriegs und des Zweiten Japanisch-Chinesischen Krieges zu schützen. Die vielleicht bekanntesten dieser China Marines waren Lieutenant General Lewis B. Puller, Major General William H. Rupertus, der Autor des Rifleman's Creed, und Clifton Cates.

Wegen der billigen Arbeitskräfte lebten die China Marines relativ komfortabel, da jeder Zug sich Chinesen leisten konnte, die viele Dinge des täglichen Lebens, wie Besorgungen oder Wäschewaschen, erledigten.

Aufgrund der erheblichen Vergrößerung des US Marine Corps während des Zweiten Weltkrieges und der Eroberung von Corregidor durch die Japaner, wo das 4. US-Marineinfanterieregiment stationiert war, wurden die China Marines hoch angesehene Exoten im Corps.

Siehe auch
 China Service Medal

Weblinks
 ChinaMarines.com (englisch)
 China Marines Band (englisch)

Militärischer Verband (United States Marine Corps)
Geschichte (Shanghai)
Zwischenkriegszeit
Republik China

redpajama_set_name: RedPajamaWikipedia


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LivingRelationships
A Prodigal Son Is Priceless
By Helen London
Even a prodigal son can change for the better. (Image: Marganingsih via Dreamstime.com)
"A prodigal son is priceless" is a popular saying among the Chinese people. This saying came from a folk story that occurred during the Ming Dynasty.
During the Ming Dynasty, there was a wealthy man who became a father when he was over 50 years old. He was very happy and named the baby Tianbao, which means heavenly treasure. After Tianbao grew up, he was very lazy and loved to squander money. The rich old man was afraid that his son would fail to keep his family's fortune, so he hired a teacher to educate his son. This teacher kept Tianbao inside the house and away from his friends, so Tianbao gradually learned the proper way to behave. Unfortunately, Tianbao's parents both passed away soon after and Tianbao lost his teacher as well.
After Tianbao's teacher left, Tianbao's old friends all came back to him. Soon, he was back to his old lifestyle and spent money like crazy. In less than two years, Tianbao exhausted everything in his household and became a beggar. By then, Tianbao regretted his past life and decided to make changes. One night, after he borrowed some books and returned home, he fell on a frozen road. He was faint with hunger and too weak to move.
Soon he was back to his old lifestyle and spent money like crazy. (Image: via pixabay / CC0 1.0)
Fortunately, a wealthy man, Wang Yuanwai, was just passing by, and he ordered his family to rescue Tianbao. After Tianbao regained consciousness, Wang asked Tianbao to stay and teach his daughter Lamei reading and writing.
The prodigal son is tricked into leaving
Lamei was very beautiful and Tianbao had lustful thoughts toward her and wanted to seduce her. Lamei finally complained to her father. Wang did not want the incident to spread outside his home and damage his daughter's reputation. He wrote a letter and said: "Tianbao, I have an urgent matter and need your help." Tianbao said: "Of course, I'll do anything you ask because I am so grateful to you for saving me." Wang replied: "My cousin lives around Bend Bridge, Suzhou. Would you take this letter to him? You can start your journey immediately." Wang then gave Tianbao some money for expenses.
Lamei was very beautiful, and Tianbao had lustful thoughts toward her and wanted to seduce her. (Image: Public Domain)
When Tianbao reached Suzhou, he started to look for Wang's cousin, but could not find him. After two weeks, Tianbao still had not found out where Wang's cousin lived. One day, he opened the letter and read what was said in the letter. It turned out that Wang had no cousin in Suzhou. Because he did not like Tianbo's ill intentions toward his daughter, he used this excuse to get Tianbo away from living with their family anymore. Tianbao was very ashamed and wanted to take his own life.
Later on, Tianbao returned to his senses and decided to work to pay back what Wang had given him. For the next three years, Tianbao worked hard during the day and studied diligently at night. He passed the national exam and became a government official. He rushed to Wang's residence, paid back the money he owed, and begged for forgiveness. Wang was so surprised to see Tianbao and pleased at his change for better that he forgave Tainbao and allowed him to marry his daughter.
From then on, the saying "A prodigal son is priceless" quickly spread. The motto of the story is that making a mistake is not that terrible; as long as you change, it is never too late.
Translated by Yi Ming and edited by Helen
Follow us on Twitter, Facebook, or Pinterest
Helen London
Tianbao
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redpajama_set_name: RedPajamaCommonCrawl


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This repository is a documentation for Volcanic Asia's development environment and methodologies

###Override T&C checked by default:
```  document.getElementById('<T&C ID>').checked = false;```

In most cases:``` document.getElementById('user_terms_and_conditions').checked = false; ```

##Multilingual Notes
#### Custom HTML/liquid for different languages
to output the language use:  ``` {{ lang_short }} ```
##### example for using ``` {{ lang_short }} ``` in conditional

 ```
 {% if lang_short == ja %} <!-- 'ja' is language code for japanese -->
      <section id="japanese_section">
          <!-- japanese HTML blurb -->
      </section>
    {% else %}
        <section id="any_other_language_section">
          <!--  any_other_language HTML blurb -->
      </section>
 {% endif %}
   ```

#####For sites multi languages that required different fonts accoring to the display language

```
{% if lang_short == "ja" %}
 <style>
     body, h1, h1 p, h2, h2 p, h3, h3 p, h4, h4 p, h5, h5 p, p, span {
       font-family:"ヒラギノ角ゴ Pro W3", "Hiragino Kaku Gothic Pro",Osaka, "メイリオ", Meiryo, "MS Pゴシック", "MS PGothic",sans-serif;!important
     }
  </style>
  {% endif %}
  ```

##Responsive notes
#### Font sizing
first: make sure that all your headings and normal text are using the ```rem``` unit and your ```<html>``` tag contains ```font-size: 62.5% ```

Then inside the media query it better to use ``` html{ font-size: 'value'% } ```

redpajama_set_name: RedPajamaGithub


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Wereldwijd bestaan talloze systemen voor de markering van wandelpaden. In Nederland en België zijn de meest gebruikelijke:

 Wit-rode markering GR-pad, LAW
 Geel-rode markering streekpaden in Nederland
 Geel-blauwe markering Nederlandse Wandelsport Bond, alleen actief in Nederland

De wit-rode markering wordt ook veelvuldig gebruikt in Frankrijk, Spanje, Portugal en Luxemburg. In voormalig West-Duitsland wordt de voorkeur gegeven aan een schuin zwart kruis op witte achtergrond, dan wel een schuin wit kruis op donkere achtergrond, terwijl in de voormalige DDR een gekleurde horizontale balk op een witte achtergrond de voorkeur geniet. Dit laatste symbool is ook te interpreteren als twee witte strepen met een gekleurde streep ertussen. Deze zelfde markering is ook gangbaar in Polen, Estland, Tsjechië, Slowakije, Hongarije en Bulgarije. In Oostenrijk wordt ze alleen gebruikt voor alpiene routes; de overige wandelwegen worden gemarkeerd met de Oostenrijkse vlag, twee rode horizontale strepen met een witte streep ertussen.

Wandelen


If you're like me, then you know what it's like to be running on a low charge from time to time. I've actually been finishing up a few emails while browsing Facebook and had my laptop shut off at a 10% charge. It was a little annoying.
It isn't always like that, but I have a few tips that will give you some extra time when you need it. I know you'll love them.
Thinking back, there were a lot of things that helped caused my laptop to power down. It probably didn't help that I had my browser running at the same time as my email app. I might have even forgotten to shut down my Word processor. Running multiple programs can really drain your battery fast, so you want to make sure you're running one thing at a time if you want a longer battery life.
The day was fast-paced and I needed my laptop on the go. It seemed like my laptop was working extra hard to cool down at the same time as power up, and that's not really very cost-efficient. I always worry about my battery over-heating, so I knew it wasn't good to start it up, but I didn't know that until it was too late. It's especially rough on the battery itself when you don't let it charge to 100%. You don't want to learn the hard way.
You can also change some settings. Because I was using it right in the middle of the day, I wasn't aware of how bright my screen was, and how hot that was making my laptop. Make sure you are only using as much as you really need. You can sit in a shady area, or maybe boot it up later if that's not possible. It's better than having it power down and losing your work.
Smart phones leave great clues. They have something called airplane mode, which is similar to power-savings modes on many laptops. What this does is basically change power-use settings so you don't have to do it manually.
Laptops constantly search for external devices. This is a handy feature when you want to sync up without having to do it yourself, but it's definitely not necessary when you're not. You can dramatically boost the life of your laptop battery by removing this next cause.
This tip is a little obscure. A lot of the programs you use have auto-features that, when combined with everything else, burden your laptop battery quite a bit. See if you can reduce this with all of your programs. There a lot of ways to improve battery life. Many of them require a lot of steps and are difficult to find. If you'd like a simplified and detailed report, you can check out this article, enter your email, and receive it for free.


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Division Menu
League Menu
#9 Nick Walker - Profile
- Team - WEST Evansville Florence Gateway Normal River City S Illinois EAST Joliet Lake Erie Schaumburg Traverse City Washington Windy City
Home | Scoreboard | Leaders | Stats | Schedule | Roster | Transactions
Stats Spray Chart
Position: 3B
Birthday: Apr 19, 1995
Hometown: Virginia Beach , Virginia
Bats/Throws: R/R
Walker is from Virginia Beach, Virginia and joined Evansville in June of 2017. Walker played college baseball at Old Dominion University. In his career with Old Dominion, Walker batted .274 with 134 RBIs, 175 runs scored, 49 doubles and 56 stolen bases.
Playoffs 2017 Evansville Otters 4 11 0 0 0 0 0 0 1 3 0 .000
Summer 2017 COPY Evansville Otters 44 143 17 39 7 0 1 13 11 17 3 .273
Total 48 154 17 39 7 0 1 13 12 20 3 .253
Batting Game Log
Sep 9 @Schaumburg L 1-3 3 0 0 0 0 0 0 0 1 0 0 0 0 0.083 0.000 0.000 0.083
Sep 6 Schaumburg W 4-3 4 0 0 0 0 0 0 0 2 0 0 0 1 0.000 0.000 0.000 0.000
Sep 5 Schaumburg L 2-7 1 0 0 0 0 0 0 0 0 0 0 0 0 0.000 0.000 0.000 0.000
Sep 3 @Gateway L 3-6 4 1 1 0 0 1 1 0 2 0 0 0 0 0.327 0.343 0.273 0.670
Aug 29 Normal L 5-7 4 1 1 0 0 0 0 0 1 0 0 0 0 0.329 0.324 0.273 0.653
Aug 27 @S Illinois L 1-3 3 1 1 0 0 0 0 0 1 0 0 0 0 0.331 0.326 0.274 0.657
Aug 23 Normal W 7-0 2 0 0 0 0 0 0 0 1 0 0 0 0 0.331 0.326 0.273 0.657
Aug 22 @Normal W 6-5 1 1 1 0 0 0 0 0 0 0 0 0 0 0.338 0.339 0.283 0.677
Aug 20 River City W 5-4 0 1 0 0 0 0 0 0 0 0 0 0 0 0.333 0.333 0.278 0.666
Aug 18 River City W 10-3 4 0 2 0 0 0 1 0 0 0 0 0 0 0.343 0.344 0.287 0.687
Aug 17 @Florence W 8-2 5 1 2 0 0 0 1 0 0 0 0 0 0 0.338 0.339 0.280 0.677
Aug 16 @Florence L 1-12 3 0 0 0 0 0 0 0 0 0 0 0 0 0.336 0.336 0.274 0.672
Aug 16 @Florence L 2-6 3 0 1 0 0 0 0 0 0 0 0 0 0 0.344 0.345 0.282 0.689
Aug 13 S Illinois W 3-0 3 0 0 0 0 0 0 1 1 0 0 0 0 0.345 0.346 0.280 0.691
Aug 12 S Illinois L 2-9 3 0 2 0 0 0 0 1 0 0 0 0 0 0.348 0.356 0.288 0.704
Aug 8 Florence L 5-7 4 0 1 0 0 0 0 0 0 0 0 0 0 0.327 0.320 0.268 0.647
Aug 6 @River City W 7-3 2 0 1 0 0 0 1 2 0 0 0 0 0 0.330 0.323 0.269 0.653
Aug 2 @Normal L 1-11 4 0 0 0 0 0 0 0 0 0 0 0 0 0.313 0.319 0.264 0.632
Jul 30 Schaumburg L 3-9 2 0 0 0 0 0 0 2 1 0 0 1 0 0.326 0.333 0.276 0.659
Jul 26 Traverse City W 6-1 3 1 1 0 0 0 0 1 2 0 0 0 0 0.322 0.346 0.284 0.668
Jul 25 Traverse City W 17-0 4 2 3 1 0 0 2 0 0 1 0 1 0 0.313 0.346 0.282 0.659
Jul 23 Washington W 13-8 0 1 0 0 0 0 0 0 0 0 0 0 0 0.282 0.311 0.257 0.593
Jul 22 Washington W 11-10 5 1 0 0 0 0 0 0 1 0 0 0 0 0.282 0.311 0.257 0.593
Jul 22 @Washington L 5-10 4 0 0 0 0 0 0 0 0 0 0 0 0 0.301 0.333 0.275 0.634
Jul 21 Washington L 6-7 4 0 1 0 0 0 1 0 0 0 0 0 0 0.319 0.354 0.292 0.673
Jul 20 @Windy City L 2-3 3 0 0 0 0 0 0 0 0 0 0 0 0 0.323 0.361 0.295 0.684
Jul 18 @Windy City W 4-0 4 0 0 0 0 0 0 0 0 0 0 0 0 0.339 0.379 0.310 0.718
Jul 16 @Gateway W 13-0 4 1 2 1 0 0 1 1 0 0 0 0 0 0.362 0.407 0.333 0.769
Jul 14 @Gateway L 5-6 5 1 1 1 0 0 0 0 1 0 0 0 0 0.340 0.380 0.320 0.720
Jul 8 Joliet W 3-1 3 1 1 0 0 0 0 0 0 0 0 0 0 0.354 0.378 0.333 0.732
Jul 7 Joliet W 10-5 4 1 2 0 0 0 2 0 0 0 0 0 0 0.372 0.400 0.350 0.772
Jul 5 @Lake Erie L 2-3 2 0 1 0 0 0 1 0 0 0 1 0 0 0.359 0.389 0.333 0.748
Jul 1 Florence L 5-8 4 1 2 0 0 0 0 0 0 0 0 0 0 0.375 0.367 0.333 0.742
Jul 1 Florence W 2-0 2 0 1 0 0 0 0 0 0 0 0 1 0 0.357 0.346 0.308 0.703
Jun 30 Florence W 5-4 4 1 1 0 0 0 0 0 0 0 0 0 0 0.346 0.333 0.292 0.679
Jun 28 @Normal W 9-6 5 0 0 0 0 0 0 0 1 0 0 0 0 0.364 0.350 0.300 0.714
Jun 27 @Normal L 2-8 2 0 1 0 0 0 0 1 0 0 0 0 0 0.462 0.500 0.417 0.962
Jun 25 S Illinois L 0-5 4 0 0 0 0 0 0 0 0 0 0 0 0 0.400 0.500 0.400 0.900
Jun 25 S Illinois W 10-1 3 0 3 1 0 0 1 0 0 0 0 0 0 0.667 0.833 0.667 1.500
Jun 24 S Illinois W 3-1 3 0 1 0 0 0 0 0 0 0 0 0 0 0.333 0.333 0.333 0.666


Abstract: In this paper we focus on corpus-linguistic studies that address theoretical questions and on computational linguistic work on corpus annotation that makes corpora useful for linguistic analysis. First we discuss why the corpus linguistic approach was discredited by generative linguists in the second half of the 20th century, how it made a comeback through advances in computing and was finally adopted by usage-based linguistics at the beginning of the 21st century. Then we move on to an overview of necessary and common annotation layers and the issues that are encountered when performing automatic annotation, with special emphasis on Slavic languages. Finally we survey the types of research requiring corpora that Slavic linguists are involved in worldwide, and the resources they have at their disposal.
Abstract: This article discusses major research areas in Slavic generative syntax. It begins with a short survey of topics, identifying important literature and useful resources. It then examines selected areas in more detail, specifically: (i) multiple wh-movement, (ii) secondary predication and control, (iii) agreement and coordination, and (iv) nominal structure and phases. Finally, several domains of inquiry are singled out for future research.
Abstract: This paper explores the connection between Slavic languages and the theoretical tenets of construction grammar, a cognitively and functionally oriented approach to linguistic analysis. The strengths of traditional Slavic linguistics consist particularly in its focus on diachronic concerns, lexical semantics, and on issues of morphology. Constructional analysis provides a rm theoretical grounding for these traditional areas and also draws attention to phenomena and issues that have been less prominently pursued by Slavic linguists. This concerns various kinds of syntactic patterning but also the domain of discourse organization and grammatical devices that serve speci c discourse functions, be it the nature of pragmatic particles, specific clausal structures, expressions of subjective epistemic stance, etc. Of interest is also the origin and evolution of such devices. This area has been generally left just about untouched in Slavic linguistics, yet it represents an enormous pool of interesting data and relates directly to theoretical questions that are presently in the forefront of general linguistic research. With respect to the evolutionary perspective, the present paper also comments on the role of pragmaticization and constructionalization and their manifestations in particular instances, including suggestions for how they can be conceptualized with the contribution of construction grammar.
Abstract: This review discusses a number of recent studies focusing on the role of phonological and morphological structure in lexical access of Russian words by non- native speakers. This research suggests that late second language (L2) learners differ from native speakers of Russian in several ways: Lower-profciency L2 learners rely on unfaithful, or fuzzy, phonological representations of words, which are caused either by problems with encoding difficult phonological contrasts, such as hard and soft consonants, or by uncertainty about the phonological form and form-meaning mappings for low-frequency words. In processing morphologically complex inflected words, L2 learners rely on decomposition to access the lexical meaning through the stem and may ignore the information carried by the inflection. The reviewed findings have broader implications for the understanding of nonnative word recognition, and the role of L2 proficiency in lexical processing.
Abstract: The last 25 years in Slavic dialectology mark the period not only of JSL's founding but also of major and multiple political, social, and economic reorganizations in predominantly Slavic-speaking states. During this period research institutions and their priorities and projects have both continued and changed; technological innovation has meant moving towards electronic dissemination, "digital humanities," and innovative modes of presenting research data and findings. In some cases major works (e.g., dialect atlases) have advanced during this period. Moreover, a new generation of scholars has had greater opportunities for mobility and therefore exposure to a variety of linguistic frameworks and approaches, which has fostered cross-border collaboration in the eld. The present essay gives an overview of progress made on dialect projects both created institutionally and individually and including both traditional (book, article) and new digital means of dissemination.
Abstract: This paper provides an overview of recent work on the first language acquisi- tion of Slavic languages. The focus is on those areas in which the most work has been done since the year 2000: referring expressions, nominal inflection, the verbal domain, and word order, with a brief mention of other topics, including the acquisition of phonology. Most of the studies reviewed here focus on typical monolingual first language development, but bilingual first language development is discussed where relevant.
Abstract: We outline some recent highlights in the application of cognitive linguistic theoretical and methodological approaches to the analysis of Slavic languages. A principal strength of cognitive linguistics is the way it focuses our attention on the continuous nature of linguistic phenomena. Rather than positing rigid categories and strict definitions, cognitive linguistics addresses the messy realities of language, facilitating the extraction of coherent patterns from the noise of human communication. We fol- low a thematic arrangement motivated by the types of variation we observe in language and the analyses proposed by Slavic linguists. These include variation across meaning and form, across modalities and genres, and across time and speakers.
Abstract: This article presents an overview of the last two decades of research in synchronic Slavic theoretical phonology and the elds it interacts with, such as phonetics, morphology, and syntax. The overview is arranged around the properties of Slavic languages that prominently figure in the recent discussion of theoretical phonology. It concentrates on the specific phenomena in Slavic, such as vowel reduction, vowel/ zero alternations, stress and pitch accent, vowel coalescence, voicing assimilation, wordnal devoicing, and consonant clusters and syllabi cation, and on how these phenomena are relevant to phonological theory and Slavic linguistics.
Abstract: This article provides a general overview of research in Slavic sociolinguistics after 1989, focusing particularly on the most recent work (2010–16). Trends in sociolinguistic research in the East, West, and South Slavic areas are discussed, and in the conclusion the article considers perspectives for future research.
Abstract: In this overview article, I seek to identify and discuss some tendencies in Slavic historical linguistics in recent years. Rather than presenting an extensive catalogue of studies on miscellaneous topics, I focus on three general issues, viz., how Slavic historical linguistics is developing in response to new theoretical ideas, methodological innovation, and "new" data. The article explores case studies from the syntax, morphology, and phonology of a number of Slavic languages and tells eight stories about Slavic historical linguistics in the 21st century.
Abstract: This article provides an update on research in Slavic psycholinguistics since 2000 following my first review (Sekerina 2006), published as a position paper for the workshop The Future of Slavic Linguistics in America (SLING2K). The focus remains on formal experimental psycholinguistics understood in the narrow sense, i.e., experimental studies conducted with monolingual healthy adults. I review five dimensions characteristic of Slavic psycholinguistics—populations, methods, domains, theoretical approaches, and specifc languages—and summarize the experimental data from Slavic languages published in general non-Slavic psycholinguistic journals and proceedings from the leading two conferences on Slavic linguistics, FASL and FDSL, since 2000. I argue that the current research trends in Slavic psycholinguistics are (1) a shift from adult monolingual participants to special population groups, such as children, people with aphasia, and bilingual learners, (2) a continuing move in the direction of cognitive neuroscience, with more emphasis on online experimental techniques, such as eye-tracking and neuroimaging, and (3) a focus on Slavic-specific phenomena that contribute to the ongoing debates in general psycholinguistics. The current infrastructural trends are (1) development of psycholinguistic databases and resources for Slavic languages and (2) a rise of psycholinguistic research conducted in Eastern European countries and disseminated in Slavic languages.
Abstract: This state-of-the- eld article traces some recent trajectories of morphological theory, illustrated via four classic problems of Slavic morphology: vowel-zero alter- nation, stem consonant mutations, paradigmatic gaps, and animacy-determined accusative syncretism. Using Russian as the primary illustrating data, one theme that emerges is that theories that leverage the distributional properties of the lexicon have made progress against previously intractable aspects of these phenomena, including idiosyncratic lexical distributions, unexpected (non)productivity, and distributions shared by distinct exponents. In turn, the analyses raise new questions.


text:
Spelaeobochica är ett släkte av spindeldjur. Spelaeobochica ingår i familjen Bochicidae.

Kladogram enligt Catalogue of Life:

Källor

Klokrypare
Spelaeobochica


"Reykjavik Youth" is a photo series of Icelandic teenagers from the years 2008-2012.
"Taken between 2008 and 2011, when Katrin was 16-19, the photos capture the parties, lazy afternoons, wild moments and experiences of solitude we can all remember from our teenage years. Ultimately, Katrin has encapsulated the poignantly sweet and vulnerable experience of blooming youth—so let yourself get nostalgic and sink into Katrin's portrait of the teenage experience."


text:
Q: Unable to upload product image in magento 1.9.2 Get an error message when trying to add product image
http://i.stack.imgur.com/BUHAk.png

A: I also encountered in the same issue when I installed magento with php 7 during the analysis I came to know the issue was coming through below file ;

E:\Xampp7\htdocs\magento19\lib\Varien\File\Uploader.php:274
  Uncaught Error: Function name must be a string in

To resolve this issue just replace below code:
At Line 274: $params['object']->$params['method']($this->_file['tmp_name']);

to
$params['object']->{$params['method']}($this->_file['tmp_name']);

A: Open file : /public_html/lib/Varien/File/Uploader.php
Find: (line: 272)
//run validate callbacks
foreach ($this->_validateCallbacks as $params) {
            if (is_object($params['object']) && method_exists($params['object'], $params['method'])) {
                $params['object']->$params['method']($this->_file['tmp_name']);

            }
        }

And Replace:
//run validate callbacks
foreach ($this->_validateCallbacks as $params) {
            if (is_object($params['object']) && method_exists($params['object'], $params['method'])) {
                $params['object']->{$params['method']}($this->_file['tmp_name']);
            }
        }

redpajama_set_name: RedPajamaStackExchange


If we had met earlier..
Would you see through my eyes..
If I had spoken the words..
Would you have seen my heart..
If I told you what we would have..
Would you have held my hand..
Maybe there is no need to wonder..
With the love we now have..
Yet if there ever a chance..
To save you the sadness you once had..
Always being your only one..


We are among the prestigious names in the industry, engaged in offering Paper Pizza Boxes for our treasured customers. This box is generally used for packing various food items to ensure their freshness for long time.
With the help of our expert team members, we have been able to provide Pizza Packaging Box.
We are among the prestigious names in the industry, engaged in offering Paper Pizza Boxes for our treasured customers.
We have carved a niche amongst the most trusted names in this business, engaged in offering a comprehensive range of Pizza Box.


Provides and easy and cost effective way of gathering your team's start and stop times at work. This is used in industries such as manufacturing, finance, health care and government.
Utilising biometry, the handpunch unit verifies an employee's identity based on the unique size and shape of their hand. This allows supervisors to be able to track and utilise labour resources, track employee attendance and automate payroll, monitor productivity and control access and track inventory.


In an attempt to reduce the number of accidents and make climbing safer, Nepal has banned solo mountaineers from climbing Mount Everest and other peaks. In addition, beginning in January 2018, all foreign climbers will need a guide. The new law also prohibits blind and double amputee climbers from trying to reach the top peaks.
More than 200 people have died in an attempt to reach Mount Everest, the world's highest mountain, since 1920. The majority of deaths have occurred within the last 40 years. Recently, an 85-year-old mountaineer died in an attempt to be the oldest human to reach the top of Mount Everest. Two Europeans died while making a solo climb last spring.
Although mountaineers die for a number of reasons, almost every fifth death is caused by acute mountain sickness. Authorities have announced that they will check medical certificates of climbers to see if they are physically capable of such a demanding task.
In addition to more safety, Nepalese authorities hope that the new law will create more jobs for mountain guides in the country. The government will also give Everest climbing certificates to high altitude guides and workers hired by foreign climbers.
Local citizens have welcomed the new law, but some officials fear that banning physically handicapped people from climbing could get them into conflict with human rights organisations.
According to statistics, 4,800 climbers have reached the top of Mount Everest since Tenzing Norgay and Sir Edmund Hillary's historic climb in 1953.
The next Olympic Games have been awarded to Paris and Los Angeles. Both cities will host the games for the third time. 2024 will mark the 100th anniversary of the second Paris Olympics. The city had already organised the summer games of 1900. The 2028 Olympics will be held in Los Angeles for the third time, after 1932 and 1984. It is the first time that the International Olympic Committee has named host cities for two summer games at once. Los Angeles originally wanted the 2024 games but agreed to hosting them 4 years later.
The IOC presented the new hosts at a time when the organisation is troubled by corruption and accusations that some members took bribes to vote for the 2016 Rio Olympics.
The 2024 Paris Summer Olympics are expected to provide jobs and growth to the city. According to city officials, the games will generate 11 billion dollars in income and create jobs for 250 000 people in the next seven years. Although Paris already has many venues ready for the games, several new ones will be built. The city wants to attract visitors not only with the best sports stadiums but also with its unique cultural and historical sites.
Los Angeles organizers have also said they want to use many existing structures built in the 1980s in order to make the games as cost-efficient as possible.
After recent terrorist attacks in Paris, London, Barcelona and other major cities , security is expected to be the main factor for both events.
Today, not very many cities are keen on organising major sports events. On one side bidding costs millions of dollars and on the other side holding the games themselves costs local authorities and governments billions.


text:
Mihai Petric (n. 7 martie 1923, satul Meleșeni, Plasa Bravicea (astăzi Călărași) - d. 5 mai 2005), a fost un pictor din Republica Moldova.

"Se pare că originalitatea parvine din două direcții: din subconștientul fiecăruia, cît și din capacitatea noastră de a vedea de a observa, de a contempla. Chiar și un pictor poate trece pe lângă un motiv plastic fără nici o tresărire. Altul se oprește buimatis și îl pictează. În felul acesta se exprimă probabil individualitatea. În felul în care ințelegea Dostoevski, adică arta nu vine atît de la intelectual, cît de la sentimentul nostru" - Mihai Petric

Studii

1935-1944. Studiază la școlile normale din Iași și Chișinău

1948.  Absolvă școala Republicană de Arte Plastice "I Repin" (Astăzi Colegiul de Arte Plastice "A. Plămădeală"), Chișinău, Moldova

1948-1955. Institutul de Arte Plastice, Facultatea de Arte Plastice, Kiev, Ucraina.

Activitatea profesională

1955-1959. Profesor la școala Republicană de Arte Plastice "I Repin" (Astăzi Colegiul de Arte Plastice "A. Plămădeală"), Chișinău, Moldova;

1956. Membru al Uniunii Artiștilor Plastici din Moldova;

1959. Membru al Comitetului de Conducere și secretar responsabil al Uniunii Artiștilor Plastici din Moldova;

1963-1980. Director al Muzeului de Stat de Arte Plastice, Chișinau, Moldova;

1972-1976. Vicepreședinte al Comitetului de Conducere al Uniunii Artiștilor Plastici din Moldova.

Expoziții

Expoziții solo:
 1964 - Casa Ofițerilor (actualmente Casa Armatei), Chișinau, R. Moldova
 1984 - Muzeul Național de Arte Plastice, Chișinau, Moldova
 1985 - Sadova și Horodiște, rn. Călărași, Moldova
 1986 - Spitalul Clinic Republican, Chișinau, Moldova
 1988 - Universitatea Tehnică a Moldovei, Chișinău, Moldova
 1993 - Centrul Expozițional "Constantin Brâncuși", Chișinău, Moldova
 1993 - "Moldexpo", Chișinău, Moldova

Expoziții în grup:

Din 1956 participă la toate expozițiile de Artă Plastică din Moldova și la cele organizate cu prilejul zilelor culturii moldovenești la Moscova, Tallinn, Riga, Baku, Tașkent, Erevan, Odesa, Lvov, Cernăuți, Minsk.

 1967 - Arta Plastică Moldovenească, Budapesta, Ungaria
 1968 - Mongolia
 1968 - Canada
 1980, 1984, 1987 - Bulgaria
 1980 - Siria
 1988 - Portugalia
 1989 - Islanda
 1990 - Spania
 1993 - România
 1995 - Ungaria

Tabere de creație:
 1963, 1968, 1975 - Gurzuf, Irak
 1982 - Bojenti, Bulgaria

Premii
1960 - Ordinul "Insigna de Onoare"

1978 - Maestru Emerit al Artei din Moldova

1989 - Artist Plastic al Poporului

1998 - Ordinul Republicii

Lucrări în colecții publice Moldova, Rusia, Ucraina, Belarus, Bulgaria

Lucrări în colecții particulare
Moldova, România, Rusia, Belarus, Bulgaria, Japonia, Israel, SUA, Canada, Grecia, Italia, Belgia, Germania, Polonia, Ungaria, Franța, Turcia.

Legături externe
 http://arhiva.art.md/petric/

Nașteri în 1923
Oameni în viață
Pictori moldoveni
Decorați cu titlul de Maestru Emerit al Artelor (Republica Moldova)


text:
ViiV/J&J's long-acting HIV regimen finally approved in US
The FDA has approved Cabenuva, a long-acting HIV treatment from ViiV and Johnson & Johnson that keeps the virus at bay with a monthly injection instead of daily pill regimen.
It follows a surprise rejection at the end of 2019, due to the information in the dossier related to chemistry, manufacturing and controls (CMC).
The clinical data supplied by ViiV was enough to support approval, however, and the FDA has finally given the go-ahead for Cabenuva.
Cabenuva is based on ViiV's long-acting integrase inhibitor cabotegravir and the non-nucleoside reverse transcriptase inhibitor (RTI) Edurant (rilpivirine) developed by J&J's Janssen pharma unit.
ViiV, which is a joint venture with GlaxoSmithKline as a majority shareholder, with Pfizer and Shionogi holding minority interests, noted that this is the first treatment to offer this less demanding treatment regimen.
The injection is delivered in a clinic and aside from clinical data supporting its safety and efficacy, ViiV said nine out of ten patients preferred the dosing regimen to their previous daily oral therapy in the studies used for approval.
This was based on a survey filled in alongside one of the trials used for approval, where 532 patients completed a single-item question at Week 48.
Results showed 88% preferred Cabenuva compared with 2% who preferred their previous daily oral HIV treatment.
The results were descriptive in nature and are not intended to imply clinical significance, ViiV noted in a statement, adding that only 59 patients chose not to answer the questionnaire.
The approval of Cabenuva is based on the pivotal phase III ATLAS studies that included more than 1,100 patients from 16 countries.
Before treatment with Cabenuva, oral dosing of cabotegravir and rilpivirine (lead-in) was administered for around one month to assess the tolerability of each therapy.
In these studies, Cabenuva was as effective in maintaining viral suppression as continuing a daily oral three-drug regimen when injected intramuscularly in the buttocks once a month throughout the 48-week study period.
In both studies, the most common adverse reactions 2% or more of clinical trial participants receiving Cabenuva were injection site reactions, pyrexia, fatigue, headache, musculoskeletal pain, nausea, sleep disorders, dizziness and rash.
Serious adverse events occurred in 4% (24/591) of patients taking Cabenuva, and 3% (17/591) of adverse events led to withdrawal.
ViiV proposes to a pricing structure where a month-long period of oral medication is provided free of charge, followed by a first high dose costing $5,940. The regimen costs $3,940 each month thereafter, reflecting the lower maintenance dose.
Another HIV vaccine falls by the wayside, as J&J admits defe...
Prospects for Johnson & Johnson's HIV vaccine effort have looked shaky since one of its shots failed to protect women in sub-Saharan Africa against infection with the virus in a phase 2
Johnson & Johnson
ViiV
Category : News / Market Access
Pharma gets social: Tesaro discovers the power of the e-patient


A man's watch can add personality and functionality to any look. At Belk, you'll love the collection of men's watches, men's designer watches and branded watches. Find a variety of styles and functionalities from smartwatches and fitness trackers, to gold watches, silver watches and more. Choose from sports watches for men, with. Explore the collection of watches for women from Belk to uncover the ladies' watch for you. From classy gold and rose gold watch styles to smart watches that can keep track of your calls and messages, there is something for everyone. From beautiful designer watches with gemstones and intricate metalwork to smartwatches and discreet fitness trackers designed to help keep your health in check, there's a range of watch options for men and women. Explore popular name brand watches for looks that are truly timeless or browse through Belk's selection to find something unique.
This site uses Akismet to reduce spam. Learn how your comment data is processed. Fossil Watches. Fossil watches come in a variety of options from leather to stainless steel, rose gold and more. Browse Belk's selection of Fossil smartwatches that easily connect with your phone for a fashionable and functional timepiece. Check out the men's Fossil watches collection for a gift he'll adore. Available in easy-to-read. Compare Belks Online products in Home Store at healthbob.tk, including Ebern Designs Belk 4 Opening 4'' x 6'' Square Picture Frame, Mercury Row Belk 8-Light Chandelier, Fiesta BELK EXCLUSIVE Square Covered Box 9-oz. Belk carries traditional items like classic pearls to be worn on your most formal occasions and unique and stylish options for more casual wear. Surprise your little one with a cute option from the kids' jewelry collection, which can make a great gift for a birthday.


This work deals with the period of maximum imperialist intervention in the South Pacific Kingdom of Tonga. It argues that the Treaty of Friendship and Protection which made Tonga a British Protectorate in May 1900, was not signed because of any concern over the welfare of the Tongans. Motivated by interest in the strategic value of the Tongan harbours Britain reached an agreement with Germany that Tonga, rather than Samoa, was a British sphere of influence. Once this agreement had been made the imperialist attitudes at the turn of the century made formal definition of British authority in Tonga inevitable. Tonga was to be a Protectorate because it was the form of control which would incur the least expense and was least likely to antagonize other powers.
Bachelor of Arts (Honours) Thesis Newcastle University.
Staff and Students of Avondale College may access a print copy of this thesis from Avondale College Library (327.9612041 P93).
Priestley, R. (1976). Anglo-Tongan relations 1899-1905 (Bachelors Dissertation). Newcastle University.


When Spanish Prime Minister Mariano Rajoy announced proposals to end the normal Spanish working day at 6pm, rather than 7pm or later, spelling the end of the afternoon siesta, I got to thinking about the value of a good nap. I work some strange hours depending on the requirements of my clients. Sometimes I'm working past midnight and again from 6 am. On those days I find that a late morning or afternoon nap is extremely beneficial.
– Naps form part of the natural cycle of the body and missing them could be worse for health than skipping a meal.
– Research published in the Journal of Clinical Endocrinology and Metabolism found that a wee snooze could restore immune and neuroendocrine biomarkers to normal health.
– Their data suggests that a 30-minute siesta could revert the hormonal impact of a night of bad sleep, helping the immune system to recover.
– A recent NASA study showed that pilots allowed to take a nap for 26 minutes during their working hours saw their efficiency increase by 34%.
The length of the nap is crucial: NASA found that the optimum length of a nap is 26 minutes and most experts seem to agree that too long a nap can be detrimental. It is generally agreed that a nap should last no longer than half an hour and should take place on a sofa or armchair and not in bed, where it is more likely that the napper will fall into a deep sleep. Finally, it is recommended that siestas form part of the regular daily routine rather than a one off.


Why should you be using Custom Office Furniture?
If you are a business owner then you must agree with me if I say that flexibility is the key to success in today's world. You need to be flexible in every respect of your business be it the product that you supply, the ability of your employee and to the office space that you utilize. In order to have the required flexibility in your office space, you need to have the service of design partition walls NY fabricator.


Place some precious gold coins in the feeding trough of a horse or mule. But do not be surprised when it pushes these aside with its mouth and, having eaten all the food, walks away from them. It sees no value in them but rather considers them to be in its way. It is because we do not appreciate God's mercy as we ought that we are in Psalm 32:9 taught, "Be ye not as the horse, or as the mule, which have no understanding: whose mouth must be held in with bit and bridle, lest they come near unto thee."
The sad fact but undeniable truth is that we do not appreciate God's mercy as we ought, and God through David instructs us in verse 11: "Be glad in the Lord, and rejoice, ye righteous: and shout for joy, all ye that are up right in heart." We have been made righteous through the forgiveness of our sins, and upright in heart by having been given a guileless spirit (verse 2); but we do not appreciate this as we ought, because we still have our sinful flesh and do not see the value of God's mercy of which David speaks in verse 10 in these words: "Many sorrows shall be to the wicked: but he that trusteth in the Lord, mercy shall compass him about."
Yes, we know the sorrows that come to the wicked. We too have sickness and disease. Death takes our loved ones away from us as well as theirs from them. But remember what David said: "Blessed is he whose transgression is forgiven, whose sin is covered." Sickness, disease, and death are God's wrath upon the wicked and His means to bring them to everlasting punishment. For us these are works of His mercy, for they are His means to prepare us for and bring us to the heavenly glory He prepared in Christ.
Be glad then and rejoice. Shout for joy! His mercy surrounds us; and no punishment can keep us from that glory, or touch us.


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Since inception, the studio staff has averaged 45-55 persons acting as producers, hosts, crew members, management, committee members and other support personnel. The staff is diverse in age, ability, experience and background. Four-village area residents, 15-years and older, may join the staff with no prior experience required.
The studio's highest calling is to extend the educational opportunities to four-village area students interested in media studies. 4VS has been very successful preparing students for entry-level industry positions.
Staff members join Four Village Studio to gain career experience, perform community service, express creative talents, make industry contacts, partake in an interesting hobby, teach the next generation of television professions, or simply spend time with a great group of dedicated people.
Contact 4VS for more details on how to become a volunteer staff member or click the "Volunteer" link below for additional information.


text:
Q: filter lines based on set of words in specific column Having input.csv as following:
field_name,field_friendly_name
LastNm,Last_Name
cntn_last_mod_wrkr_full_nm,Last_Name
contact_last_nm,Last_Name
contact_first_last_nm,Last_Name
last_english_nm,Last_Name
last_pronunciation_nm,Last_Name
last_nm,Last_Name
lead_space_last_nm,Last_Name
last_mod_usr_nm,Last_Name
lcl_last_nm,Last_Name
adobe_last_topic_nm,Last_Name
last_changed_user_nm,Last_Name
last_purchased_product_service_nm,Last_Name
last_imported_source_nm,Last_Name
submt_last_nm,Last_Name
cntct_last_nm,Last_Name
cust_submt_last_nm,Last_Name
cust_cntct_last_nm,Last_Name
last_mod_by_nm,Last_Name
last_mod_als_nm,Last_Name
last_mod_nm,Last_Name
ship_last_nm,Last_Name
billing_last_nm,Last_Name
last_upd_by_nm,Last_Name
wrkr_last_nm,Last_Name
trns_line_itm_last_chg_psn_nm,Last_Name
trns_line_itm_last_cre_psn_nm,Last_Name
trns_hdr_last_chg_psn_nm,Last_Name
altr_last_nm,Last_Name
trns_last_chg_nm,Last_Name
lastrepaction_nm,Last_Name
last_build_nm,Last_Name
LegalLastNm,Last_Name
ManagerLastNm,Last_Name
4-LastNm,Last_Name
NextLevelManagerLastNm,Last_Name
ManagerLegalLastNm,Last_Name

from this file I would like to filter on column1 where condition is
column1 value should be made of given set of words in this case (last, name, nm, lst, -, _, [0-9] ) and exclude if contains any other words.
And also update column2 as "Found".
And my search should be case insensitive.
LastNm,Found
last_nm,Found
4-LastNm,Found

I'm using this way wchich doesn't work:
awk -v q="'" --field-separator ',' '((tolower($1) ~ /last/) && (tolower($1) ~ /name/)) || ((tolower($1) ~ /last/) && (tolower($1) ~ /nm/)) && ($2="found") {print $1 "," $2  }' raw.csv

A: With GNU awk, gensub could be used to remove all those words, print if empty:
awk -F , -v OFS=, 'gensub(/last|lst|name|nm|[0-9_-]*/,"","g",tolower($1))=="" {
    $2="found";
    print $1, $2
}' file

Unlike sub/gsub, gensub leaves the original record intact and instead returns the resulting string. The same approach could be used with standard awk by copying field into a variable.
To include more characters than [0-9_-], you could use [^[:alpha:]] (i.e. anything that isn't a letter):
last|lst|name|nm|[^[:alpha:]]

A: Try this,
awk -F, -v OFS=, '
{
split($1,w,/[^[:alnum:]]/);
for (i in w) {
    if (!(match(tolower(w[i]),/\<([0-9]*|last|nm|name|lastnm|lastname)\>/))) next;
}
$2="Found"; print;
}' file

Output:
LastNm,Found
last_nm,Found
4-LastNm,Found

Explanation:

*

*split field $1 by all not ([^.]) alphanumeric ([:alnum:]) characters to get list of words.

*for loop over these words.

*if a word does not match the given regex holding the allowed words, jump to next record.

*if that did not happen, we can finally assign $2="Found" and print the record


Zoe lives in Newtown, Wellington and identifies as a queer woman. She spends her time showing people photos of her nibbling, laughing with the wonderful people in her life and discovering the joys of Microsoft Office. Her poetry is a means of reflection on the cycles of her life.


text:
Pastor stands by Pres. Trump after vulgarity during MLK Day proclamation
by: Michelle Rotuno-Johnson
Posted: Jan 12, 2018 / 05:04 PM EST / Updated: Jan 12, 2018 / 05:04 PM EST
WASHINGTON (AP) – President Donald Trump did not respond to questions about his use of a vulgarity or his question about why the U.S. should accept more immigrants from Haiti and African nations than from countries like Norway.
The questions came Friday in the White House when Trump signed a proclamation honoring Martin Luther King Jr. Day, noting the contributions of a "great American hero."
Trump did not respond to several questions about the incident, including whether he actually used vulgar language to describe African nations, or if he is racist.
The president said at the White House that "love was central" to the slain civil rights leader. Trump said the nation celebrates King for "standing up for the self-evident truth Americans hold so dear, that no matter what the color of our skin or place of our birth, we are all created equal by God."
A prominent evangelical supporter of President Donald Trump's is standing by him after Trump used a vulgarity to describe African countries.
The Rev. Robert Jeffress of First Baptist Dallas says that, apart from the reported choice of words, "Trump is right on target in his policy."
Jeffress says Trump has a constitutional responsibility as commander in chief to protect the U.S. "above the needs of other countries." Jeffress says Trump has courage and deserved gratitude for his leadership.
Jeffress sent out the statement as many evangelical leaders condemned the remarks as offensive and racist.
People briefed on the Oval Office conversation on immigration reform Thursday said Trump questioned why the U.S. would accept more immigrants from Haiti and what he called 'shithole countries" in Africa.


AI – Programmed the opponent racer AI systems.
Core – Programmed game manager and loading screen systems. Import and setup all art, environment, props, and other assets.
Cross-Platform Development – Implement VR for Oculus Rift, Oculus Go, Samsung Gear VR, and Google Daydream. Setup and maintained build pipelines for all platforms.
Engine – Setup and maintained project hierarchy, folder structure, game settings, and engine settings. Performance and optimization for all platforms.
Gameplay – Programmed race tube and spline system with countdown, start, and end of race. Programmed object collection and pooling system for in-game collectible items. Programmed player boost system. Programmed checkpoint ring system.
Graphics, Lighting, & Cinematics – Programmed and setup first person/ third person camera and camera sequences. Programmed and setup lighting, materials, shaders, visual fx, and post-processing. Ensure compatibility with all platforms.
Input – Programmed gaze flight control system for player movement. Programmed Rift, Oculus Go, Gear VR, Google Daydream, PC non-VR, console non-VR, and mobile non-VR controller input systems.
Tools – Programmed 3D world space race track system with track editing tool for building new race tracks.
Survios VR Arcade Demo – Created an Oculus Rift PC demo that was put on display with our VR motion chair partner company at the Survios VR arcade!
Twitch Live Stream Game Announcement – I personally live streamed the public announcement of Born to the Sky and Vrainiac's partnership with Enjin Coin on Twitch with a gameplay walkthrough and Q&A.


text:
Le Forze armate yemenite (in arabo: القوات المسلحة اليمنية) sono le forze armate dello Yemen. Sono composte dall'Esercito yemenita (inclusa la Guardia repubblicana), la Marina militare yemenita (inclusi i Marines), la 1ª Divisione corazzata e la Al-Quwwat al-Jawwiyya al-Yamaniyya (Forza Aerea Yemenita, che include la forza di difesa aerea). Le forze armate yemenite sono sotto una continua riorganizzazione. Le forze aeree le forze di difesa aeree sono ora sotto un unico comando. La marina militare è concentrata ad Aden.

Storia
La Repubblica Araba dello Yemen e la Repubblica Democratica Popolare dello Yemen si sono riunificate il 22 maggio del 1990.

Lo Yemen ha usato bambini soldato tra il 2001 e il 2004. Bambini soldato sono usati anche dalle milizie tribali come risulta dal 2011.

Sin dalla guerra civile nel 2014, Le forze armate yemenite si sono divise in lealiste fedeli al presidente 'Ali 'Abd Allah Saleh e pro-governative fedeli al presidente 'Abd Rabbih Mansur Hadi.

Struttura
Il comandante supremo delle forze armate yemenite è il Feldmaresciallo 'Abd Rabbih Mansur Hadi, il presidente dello Yemen dal 2012.

Il numero del personale militare attivo nello Yemen è piuttosto alto, sommando, lo Yemen ha la forza militare più numerosa nella Penisola arabica dopo l'Arabia Saudita. Nel 2012, il numero di truppe attive era stimato in 66.700 uomini nell'Esercito, 7000 marinai e 5000 piloti. Nel settembre del 2007, il governo yemenita ha annunciato la reintroduzione della leva obbligatoria. Il budget di difesa dello Yemen, che nel 2006 rappresentava approssimativamente il 40% del budget totale del governo yemenita rimarrà alto finché ci saranno minacce alla sicurezza interna dello Yemen.

Note

Storia dello Yemen


The organizers of the 20th European Carbohydrate Symposiums (EUROCAB 2019) invite companies and organizations in research products and services in the field of glycosciences and beyond to financially support the conference. This conference will be highly interesting for your company to allow exposure of your activities to a large and specialized community of scientists. Therefore, please don't forget to include EUROCARB 2019 in Leiden in your plans and budget for next year!
EUROCARB brings together over 500 scientists working in the glycosciences from all around the world.
The programme encompasses workshops, parallel papers sessions, and poster viewing. The programme is organized in such a way that maximum time is allowed for networking. Similarly, this offers optimal conditions for companies to display and promote their activities and products.
Download the sponsorship brochure below for information on sponsorship and exhibition options, or contact Congress by Design through eurocarb@congressbydesign.com to review your options and reserve your benefit package.


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Издательство Taylor&Francis
BUBBLE DYNAMICS AND ELUTRIATION STUDIES IN GAS-FLUID1ZED BEDS
SAXENA S.C.; MATHUR A.; SHARMA G.K.
Журнал: Chemical Engineering Communications
In order to adequately interpret the heat and mass transfer data taken in a gas-fluidized bed, it is essential to know the bubble dynamics and solids movement in the bed, and solids elutriation from the bed. To generate information on these aspects, an experimental facility has been designed, fabricated and successfully tested. This consists of a two-dimensional fluidized bed with its gas supply and cleanup system. The bubble dynamics and solids projection from the bed are recorded by a high-speed movie camera. The films are analyzed on a photo-optical data analyser and digitizer provided with an electronic graphics calculator connected to tape printer and a Teletype terminal interfaced with a computer. The analysis of recorded bed dynamics suggests that for large particles the bubbles grow to be non-spherical and these rise almost above the bed surface before bursting when the wake remains intact while the solids bulge at the bubble nose ruptures to release the bubble gas. It is concluded unambiguously that the solids projected in the freeboard originate from the bubble bulge, and not from the bubble wake as commonly believed. A series of experiments is proposed which will facilitate the development of a general quantitative theory for solids elutriation from industrial fluidized beds. In addition, a fairly complete review of the work done on bubble dynamics, solids movement in the bed, and solids projection from the bed surface in two- and three-dimensional fluidized beds is presented. Thus, on the whole the present work reviews the state-of-the-art of these three different fluid-bed aspects, and reports new data.


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Der easycredit BBL-Pokal 2018 ist die neunte Austragung des Pokalwettbewerbs im deutschen Vereinsbasketball der Herren als Ligapokal der ersten Basketball-Bundesliga. Die Organisation dieses Wettbewerbs untersteht dem Ligaverband der Basketball-Bundesliga und ermittelt den deutschen Pokalsieger im Vereinsbasketball der Herren.

Modus
Für die Qualifikation zu diesem Wettbewerb sind die Ergebnisse in der Hinrunde  der Basketball-Bundesliga 2017/18 entscheidend. Wie im Vorjahr wird anhand der Ergebnisse der Bundesliga-Hinrunde eine Pokaltabelle eingerichtet, in der die Spiele des Gastgebers des Final Fours keine Berücksichtigung finden.

Neben dem automatisch qualifizierten Gastgeber sind die zusätzlich sechs bestplatzierten Mannschaften dieser Pokaltabelle qualifiziert. Die Paarungen werden per Losverfahren bestimmt, welches auch über das Heimrecht in der Qualifikationsrunde entscheidet. Der Sieger beziehungsweise das Weiterkommen im Wettbewerb wird im K.-o.-System innerhalb eines regulären Basketballspiels ermittelt.

Austragung
ratiopharm Ulm war als Gastgeber automatisch für das Final Four qualifiziert. Die drei weiteren Plätze für das Finalturnier wurden am 20. und 21. Januar 2018 ausgespielt.

Das TOP FOUR genannte Final-Four-Finalturnier fand am 17. und 18. Februar 2018 in der Ratiopharm-Arena in Neu-Ulm statt.

* Platzierung nach der Hinrundentabelle der Basketball-Bundesliga. Bei den anderen Mannschaften ist jeweils die Platzierung der Pokaltabelle angegeben.

Siehe auch
 Deutscher Pokalsieger (Basketball)
 Liste der Ergebnisse des BBL Top Four

Weblinks
 easycredit Basketball Bundesliga – easycredit BBL-Pokal – Informationsseite

Basketballveranstaltung 2018
2017


The State Government has announced $64 million of cuts to the education system, set to take place in 2019.
Education Minister Sue Ellery said the measures, which include shutting the Schools of the Air program and closing six department camp sites, were necessary after the Upper House rejected the gold royalty increase.
* Six camp school sites run by the Department of Education will close. These are not the core business of education and there are other government and commercial providers of similar services.
* Schools of the Air (SOTA) will also close. The School of Isolated Distance Education (SIDE), which is the major provider of distance education for rural and regional students, will take over the provision of education services delivered by SOTA. This eliminates duplication.
* Tuart College will be repurposed and, while the site will be retained by the Department of Education, students will no longer be enrolled, pending a decision to be made on its future use.
* Program delivery at Canning College will change to deliver programs to overseas fee-paying students only, focusing on WA's international education sector.
* Funding for Landsdale Farm School will cease, with the intention of finding an alternate provider for this community resource.
* Residential accommodation in Moora and Northam will close.
* Intake into the Level 3 classroom teacher program will be on hold until 2020.
* Funding for Gifted and Talented programs at 18 schools will be reduced by 25 per cent.
* Fees for holiday swimming lessons (VacSwim) will increase, after minimal changes to fees over the past 14 years. Fees for a 10-day program will increase from $13.50 to $30, or $20 for families with a concession card.
Ms Ellery said there was a need "do things differently" given the state of the budget.
"This has not been easy, but tough decisions have had to be made to get WA's finances back on track to fix the mess left by the previous Liberal-National government.
"We've asked all parts of the community to help contribute to budget repair - the public sector, business, industry, individuals and families.
"Unfortunately, the Liberals and Nationals blocked a reasonable change to the gold royalty rate, and chose to protect profitable gold miners from doing their bit. This has meant other parts of the community, like education, have been forced to shoulder more of the burden.
Opposition Leader Mike Nahan said West Australian parents had every right to be angry and concerned about the cuts.
"It insults parents to say these cuts are about budget repair when the Treasurer last week admitted he had blown the budget within three months of bringing it down," he said.
"The cuts had nothing to do with the former Government and everything to do with the out-of-control spending of the current Government.
Nationals leader Mia Davies said the cuts to regional school, including the closure of the School of the Air and residential colleges in Moora and Northam, were a "cruel Christmas present" to country students.
"There is no good news for staff, students and families who rely on School of the Air, or attend the Northam or Moora residential colleges – they have been left facing the prospect of finding a new school or a new job," she said.


The morning session was sung from the 1991 revision of the Sacred Harp.
Mr Nichols introduced Dr James Dooley, retired Vice-Chancellor of the University, who welcomed the singers, and spoke im memory of Dr Eva Adcock, founder of the Mountain Heritage Day singing.
The afternoon session was from Christian Harmony. All selections "Carolina book" except "Alabama book" as noted.
Mike Nichols again welcomed the singers; as did Dr Dooley, who led 255-Watchman.


This TechFile provides information about the array support library (ASL) for Fujitsu ETERNUS DX60/DX80/DX90 and ETERNUS2000 Arrays (Active/Active) on Veritas Volume Manager (tm) 5.0 and 5.0MPx for Linux (RHEL).
Note: The package name and the above installation instruction is common for both RHEL4 and RHEL5.
Size        : 6434                             License: Copyright (c) 2009 Symantec Corporation. All rights reserved. Symantec and the Symantec Logo are trademarks or registered trademarks of Symantec Corporation or its affiliates in the U.S. and other countries. Other names may be trademarks of their respective owners. The Licensed Software and Documentation are deemed to be "commercial computer software" and "commercial computer software documentation" as defined in FAR Sections 12.212 and DFARS Section 227.7202.


Malt Cottage is a terraced Cotswold stone cottage, which offers generous living space that has been attractively updated by the current owners. It serves them well as a second home but is also a very good holiday let and has provided a good additional income. It is a short walk from the Market Square and all the town's facilities, pubs and shops. The accommodation is well proportioned and arranged over two floors with the attic being a very useful storage area with a pull-down ladder. Period features include the Cotswold stone fireplace, a few exposed beams and some high ceilings. The neutral décor is attractively done, all of which contributes to a light and airy feeling throughout. The front and rear gardens are enclosed and landscaped to provide places to sit out and are easily managed. The area is well catered for with excellent hotels and restaurants. Kingham Station provides a direct rail service to London Paddington and there is access to both the north and London via the A40 with connections to the M40 at Oxford.


The sweeping bend in the rear leg posts and the form fitting curve of the back slats both add to the beauty and comfort of this handcrafted rocking chair. Made of red oak with a hickory bark seat. Hickory bark is a very strong seating material that wears well and develops a beautiful patina with age.
This rocker is also available with a tape seat made of durable cotton canvas or woven seagrass.


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2015 Nissan Leaf SL for Sale in Seattle, Washington
2015 nissan leaf for sale seattle washington2015 nissan leaf dealer seattle washingtonnissan leaf for sale seattle washingtonused nissan leaf for sale seattle washington2015 nissan leaf best price seattle washington
(Posted on Apr 9, 2018 at 09:10AM by Michelle Bogle)
Owning a vehicle comes with a lot of costs – there are the usual suspects like financing and insurance fees, as well as regular maintenance and repairs. Add in rising fuel prices and it can feel like your pay check disappears before it even hits your bank. And, if you are driving an older model year gas guzzler, it certainly might!
Instead, why not consider a preowned all-electric vehicle, like a 2015 Nissan Leaf SL? This battery-powered performer will not only excite you with its range and smooth performance, but it will also eradicate expensive gas station visits for as long as you own the car.
The 2015 Leaf runs on a 24-kWh lithium-ion battery, which sends electricity to the 80 kW AC synchronous motor that produces 107 horsepower and 187-lb.-ft. of torque. Charging is managed by a 6.6-kWh charger, which restores a fully depleted battery in four hours when a 240-volt Level 2 charging station is used. DC quick-charging is also optional, which lets you recharge the battery to 80 percent of capacity in about 30 minutes at more than 500 CHAdeMO sites nationwide. The range on the 2015 Leaf SL is rated at 84 miles and will only cost you a few dollars in electricity costs – less than your daily premium take-out coffee.
To learn more about the 2015 Leaf SL and how you can kiss traditional fossil fuels goodbye, contact us at Kirkland Nissan to schedule a test drive.
2015 Nissan Leaf SV for Sale in Seattle, Washington
(Posted on Mar 24, 2018 at 08:23AM by Michelle Bogle)
Seattle, in honor of Earth Day, which is less than a month away, why not consider slipping into something more eco-friendly, like a preowned 2015 Nissan Leaf SV? This all-electric vehicle is made for commuters in the PNW, boasting full plug-in performance and great range, allowing you to commute to work with zero emissions.
Under its sleek design, the Leaf is powered by an 80-kW electric motor, which draws power from its 24 kWh lithium-ion battery pack. Combined, this provides drivers with 107 horsepower and 187 pound-feet of torque, along with a range of 84 miles on a single charge.
And, speaking of charging, the 2015 Nissan Leaf SV is equipped with a 6.6 kW on-board charger that can be used with any 220V power source. It can juice up a fully depleted battery in about five hours, which is faster than the base S trim.
Inside the EV, the mid-range SV model sports a 7-inch display, six-speaker audio system, navigation, and the CARWINGS app integration. Cruise control is also standard, which complements the Leaf's whisper quiet operation, and the recycled cloth upholstery is a nice touch as well.
Ready to go for a spin? Call us at Kirkland Nissan in Seattle, Washington, to schedule your test drive in a used 2015 Leaf.
(Posted on Feb 7, 2018 at 06:27PM by Michelle Bogle)
An unfair uncertainty often plagues the electric vehicle market with drivers overlooking the plug-in segment based on ill-advised myths of poor range, high electricity costs, and jarring on-road dynamics. But, Nissan has worked hard to change these negative notions with the availability of the 2015 Leaf SV.
This plug-in performer is anything but unreliable, expensive or fickle. Instead, it's a great preowned EV well-suited for life in Seattle, delivering both efficiency and performance in equal measure.
Under its aerodynamic exterior, the 2015 Nissan Leaf SV's motor is powered by a 24-kWh lithium-ion battery, which outputs an impressive 107 horsepower and 187 lb-ft of torque. With a front-wheel drivetrain, integrated Vehicle Dynamic Control System, and sturdy rack-and-pinion steering, this EV takes full command of the road, but with a whisper quiet operation that's smooth, engaged and refined.
On a single charge, it yields an 84-mile range, which is enough to quell even the most anxious of commuters. And when it comes time for a charge, you won't be left with empty pockets either, since the 2015 Leaf can be refreshed for as little as three dollars in less than five hours. That's cheaper than your two-coffee-per-day habit!
See for yourself how efficiency and performance come together in the 2015 Leaf SV. To schedule your test drive, contact us at Kirkland Nissan today.
2015 Nissan Leaf S for Sale in Seattle, Washington
A common misconception is that all-electric vehicles, while incredibly efficient, often leave a lot to be desired when it comes to comfort. But in actuality, that misconception couldn't be further from the truth.
Take the 2015 Nissan Leaf S, for example. This mid-size EV boasts a spacious interior that's generous, cozy and great for Seattle area families, with space for up to five passengers.
The exterior of the 2015 Leaf is thoughtfully designed to maximize fuel efficiency with an aerodynamic body that reduces drag and wind noise and promotes airflow. It's practical and functional by nature, yet sleek and stylish too.
Inside, the Leaf S features a well thought out cabin that's styled to maximize comfort. Riding on a 106.3-inch wheelbase, it provides an ample two-row design, boasting an impressive total passenger compartment volume of 92.4 cu. ft.
Here's an overview of its specs:
Headroom: 41.2 inches
Legroom: 42.1 inches
Hip Room: 51.7 inches
Shoulder Room: 54.3 inches
In the rear cargo area, the Leaf is equipped with a spacious trunk that can hold loads of groceries, baggage or sporting equipment with ease. With the second row seats in an upright position, you can count on 23.6 cu. ft. of room or 30 cu. ft. with the seats folded flat. How's that for versatility?
To learn more about the 2015 Leaf S, including its pricing and specs, contact us at Kirkland Nissan in Seattle, Washington to speak with a product advisor.
2015 Nissan Leaf S Offers Seattle Drivers Top Tech
If you share a penchant for the latest tech, but also care about your impact on the environment, a preowned 2015 Nissan Leaf S might just strike the perfect balance for you. This all-electric vehicle creates zero emissions, but comes loaded with many innovative features that make it a top choice for Seattle area tech connoisseurs.
The 2015 Leaf is powered by an 80 kW AC synchronous electric motor with 24 kWh lithium-ion battery that churns out 107 horsepower and 187 lb-ft of torque. Juicing up this EV takes about eight hours with the base 3.6 kW onboard charger, but a 6.6 kW version is available, which reduces charging time to approximately five hours.
Inside, technology abounds, despite the S trim's entry-level position. A rearview camera, Bluetooth, and heated front and rear seats all come standard, as does a four-speaker AM/FM/CD audio system with USB and auxiliary inputs, plus a 4.3-inch display.
Watch this video for a closer look:
Best of all is the price. A used 2015 Leaf S will run you well below the $15K price range, which is quite economical considering the technology and innovation that this EV brings to the table. When you factor in zero fuel costs, you'll be laughing all the way to the bank.
To schedule your test drive in a preowned Leaf, contact us at Kirkland Nissan today to schedule your test drive. You can also browse our online inventory by clicking here.
(Posted on Dec 12, 2017 at 08:26AM by Michelle Bogle)
For Seattle area drivers in search of an all-electric vehicle that handles more like a regular car, the 2015 Nissan Leaf S is a smart, eco-friendly choice. If you haven't had a chance to test drive one, we have a number of models in our preowned inventory at Kirkland Nissan.
The 2015 Leaf is powered by an 80 kW lithium-ion battery and 107-horsepower motor that generates 187 lb-ft of torque, resulting in a 0-to-60-mph sprint in about 10 seconds flat – not bad for an all-electric vehicle. As for charging, the Leaf S is quite speedy – the base 3.6 kW onboard charger takes about eight hours on a 220-volt line, or you can upgrade to the optional 6.6 kW version, which reduces charging to five hours.
The range of the 2015 Leaf S clocks in at 84 miles and earns an EPA city/highway fuel economy equivalent of 126/101 mpge. If you are a short-distance traveler or have access to a charging station while at the office, the Leaf is a fantastic solution for commuters who want to wipe out monthly fuel costs.
As for standard features, the S trim comes very well-equipped with Nissan's Intelligent Key system, which allows you to start the car without removing keys from your pocket or purse. It also includes heated front and rear seats, Bluetooth, split folding rear seats, a rear backup camera, a CD player with USB and auxiliary connections, and a heated leather-wrapped steering wheel. Other features include power windows, locks and mirrors, 16-inch steel wheels with full covers, automatic temperature control, a rear defroster and a vehicle security system.
Have a closer look at this video review:
To schedule your test drive in a preowned 2015 Nissan Leaf S, contact our dealership today. You can also browse our online EV inventory, which features many other great models at affordable prices.


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Tag: Epigenetics
New Research Points to HDAC3 Inhibition as a Potential Game-Changing Treatment for Specific Lymphoma Subtypes
By Sucharita Mistry, PhD
B-cell lymphomas such as diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) are blood cancers of the immune cells. A vast majority of B-cell lymphomas typically display a high frequency of genetic alterations. Since lymphomas show remarkable genetic diversity, a big challenge for scientists is not only to determine which genes are mutated in these diseases, but also to identify "actionable" genetic alterations that can respond to targeted therapies.
"Discovering how different mutations are involved in causing the disease is a major key to advancing novel mechanism-based precision therapies and immunotherapies for lymphomas, with potentially less toxic side-effects," says Dr. Ari Melnick, a world-renowned physician-scientist at Weill Cornell Medicine.
Dr. Melnick led groundbreaking research that defines the genetic underpinnings of CREBBP mutation in lymphomas, paving the way for new therapeutic avenues. The findings of this study were recently published in Cancer Discovery.
The CREBBP gene encodes a kind of histone acetyltransferase (HAT), an enzyme that introduces small chemical tags called acetyl groups on histones, which are the major structural proteins of chromosomes. The chemical modifications on histones are termed as epigenetic changes, and they determine whether genes are turned on or off. The CREBBP gene, which is an epigenetic modifier, is frequently mutated in DLBCL and FL.
The Melnick research team, in collaboration with scientists at the MD Anderson Cancer Center, characterized the functional consequences of CREBBP mutation in lymphomas. Using a powerful CRISPR gene-editing technology, the researchers engineered lymphoma cell lines that differed only in the CREBBP mutation status. The research team discovered two different types of CREBBP mutations that either truncate the protein or inactivate the HAT domain, the latter associated with poor clinical outcomes.
This study showed that CREBBP mutation disrupts key biological pathways resulting in abnormal silencing of tumor-suppressive and antigen-presenting pathway genes. This disruption allows lymphoma cells to hide from the immune system so that they cannot be recognized and attacked by the T-cells that play an essential role in the body's immune response.
More importantly, the malfunction in immune surveillance was restored by an HDAC3 inhibitor, a drug that specifically reverses the histone acetylation defect caused by CREBBP mutation. Notably, selective inhibition of HDAC3 reversed the epigenetic abnormalities, halted lymphoma growth and induced the expression of major histocompatibility (MHC) class II protein, enabling the T cells of the immune system to recognize and kill lymphoma cells. The research team also demonstrated that combination of an HDAC3 inhibitor with an immune checkpoint inhibitor (PD-1/PD-L1 blockade) results in synergistic anti-lymphoma immunity effects.
These findings uncover a novel mechanistic link between CREBBP mutation and immune surveillance dysfunction in lymphomas that can be counteracted by an HDAC3 inhibitor, providing a potentially game-changing approach for restoring anti-tumor immunity.
"HDAC3 inhibition provides an attractive therapeutic avenue for DLBCL and FL and may have enhanced potency in CREBBP-mutant tumors," says Dr. Melnick. "We are very excited to translate this research into clinical trials that could potentially lead to the development of novel mechanism-based immune epigenetic therapy for CREBBP-mutant lymphomas."
Author jacquiehemoncPosted on June 29, 2020 Categories Laboratory Research, Patient Education, Research PublicationsTags Cancer Discovery, CREBBP Mutations, CRISPR, diffuse large B-cell lymphoma, Dr. Ari Melnick, Epigenetics, follicular lymphoma, HDAC inhibitorsLeave a comment on New Research Points to HDAC3 Inhibition as a Potential Game-Changing Treatment for Specific Lymphoma Subtypes
Re-Thinking Epigenetic Therapies for B-Cell Lymphoma
Histone deacetylase inhibitors (HDACi) are small molecules that alter the function of histones, or proteins that bind to DNA and help to determine chromosome shape and gene activity. In cancer treatment, HDACi are traditionally considered epigenetic drugs because of their capacity to modify gene expression to halt tumor cell division, but new research from the Cerchietti Research Laboratory at Weill Cornell Medicine poses rationale for studying the inhibitors' biological effects through a different lens – their impact on cell metabolism.
Benet Pera, Ph.D., along with Weill Cornell colleagues, as well as researchers from the Helmholtz Institute of Computational Biology in Germany and the Lady Davis Institute for Medical Research in Canada, conducted the study to improve the efficacy of HDACi in people with B-cell lymphoma, which is relatively low compared to that in T-cell lymphoma. Several HDACi, including vorinostat and romidepsin, have been approved by the United States Food and Drug Administration (FDA) for treatment of certain T-cell lymphoma subtypes.
Contrary to their namesake, histone deacetylase inhibitors are able to affect a long list of non-histone proteins, among them metabolic enzymes. These agents can be more appropriately referred to as lysine deacetylase inhibitors (KDACi). Due to the activity of KDACi in proteins involved in metabolic pathways, Pera et al. investigated the effects of the KDACi panobinostat in the cell metabolism of relapsed/refractory diffuse large B-cell lymphoma (DLBCL) patients enrolled in a phase II trial. Metabolic profiling of the patients' plasma before and after KDACi-treatment demonstrated that panobinostat prompts DLBCL cells to rely on a certain metabolic pathway, the choline pathway, for survival. The scientists found that in the lab, treating the cancer cells with a choline pathway inhibitor in combination with panobinostat produced superior anti-lymphoma effects in vitro and in animal models.
"We are studying these so-called 'epigenetic' drugs from a different angle, hoping that metabolomics might hold the key to improving their clinical efficacy," says Dr. Pera.
The research data recently published in the open-access journal EBioMedicine help to substantiate the team's innovative re-application of epigenetic reagents, demonstrating the value and promise of the metabolic mechanisms by which KDACi/HDACi can improve current therapeutic options for people with B-cell lymphoma. The results also highlight the need to explore the unknown biological effects of this class of drugs before they can be successfully implemented in a clinical setting.
Author jacquiehemoncPosted on January 30, 2018 Categories Laboratory Research, Lymphoma Program News, UncategorizedTags B-cell lymphoma, Benet Pera PhD, choline pathway, Epigenetics, HDAC inhibitors, HDACi, Histone deacetylase inhibitors, KDACi, Leandro Cerchietti MD, lysine deacetylase inhibitors, metabolism, metabolomics, panobinostat, T-cell lymphomaLeave a comment on Re-Thinking Epigenetic Therapies for B-Cell Lymphoma
Global Collaboration: Lymphoma Researchers Attend Workshop at Shanghai Institute of Hematology
In early July, several researchers from the Weill Cornell Medicine/NewYork-Presbyterian (WCM/NYP) Lymphoma Program traveled to Shanghai, China to participate in the first Lymphoma Research Workshop, jointly sponsored by WCM/NYP and Shanghai Institute of Hematology (SIH). The workshop aimed to foster clinical and translational research exchange and collaboration, with the goal of further global alliance with leading Chinese institutions.
Our own Drs. Leandro Cerchietti, Peter Martin, Ari Melnick, Kristy Richards, and Jia Ruan were in attendance. Drs. Melnick and Ruan co-organized the workshop with Drs. Saijuan Chen and Weili Zhao from SIH. SIH and its affiliated Ruijin Hospital (RJH) is a leader in human genomics and lymphoma research in China.
Dr. Ari Melnick (Left) and Dr. Jia Ruan
Dr. Melnick began by introducing the lymphoma research missions at WCM/NYP and provided an overview of our translational program, which integrates state-of-the-art genetic, epigenetic, and proteomic approaches to study lymphoma pathogenesis and inform development of mechanism-based therapeutics.
Dr. Zhao followed with a review of the recent lymphoma program developments at Ruijin Hospital, which focuses on building a multi-disciplinary diagnosis and treatment team. RJH's translational development has been aimed at building a lymphoma biobank, next-generation sequencing, system biology, and biomarker investigations to support clinical research.
Dr. Peter Martin (Left) and Dr. Leandro Cerchietti
On the project level, Dr. Cerchietti discussed bench-to-bedside translation of epigenetic modifying agents, such as novel treatments that sensitize chemotherapy responses in patients with diffuse large B-cell lymphoma (DLBCL). Dr. Martin then provided a comprehensive overview of the management approach for DLBCL in the U.S., reviewing important study design and findings of DLBCL clinical trials that incorporated novel agents, including epigenetic modifiers. Dr. Richards spoke about promises and challenges in canine lymphoma research in both the disease and drug development models.
Dr. Kristy Richards
Additionally, Dr. Pengpeng Xu from RJH presented preliminary data of a phase 1 study using an epigenetic hypomethylating agent in combination with chemotherapy for DLBCL patients. This joint clinical project developed from the two institutions' shared translational interest and expertise in exploring therapeutic potential of epigenetic agents in lymphoma.
Drs. Ruan and Melnick concluded the workshop by thanking the hosts at the Shanghai Institute of Hematology and Ruijin Hospital for their gracious hospitality. Faculty from both institutions are impressed by the progress of the ongoing collaboration and support further development of translational and clinical projects in the future, including academic exchange and joint translational and clinical trials.
Author jacquiehemoncPosted on July 26, 2017 Categories Laboratory Research, Lymphoma News, UncategorizedTags Ari Melnick MD, China, clinical trials, DLBCL, Epigenetics, global collaboration, Jia Ruan MD, Kristy Richards MD, Leandro Cerchietti MD, lymphoma research, NewYork-Presbyterian Hospital, Peter Martin MD, Shanghai, translational research, Weill Cornell Lymphoma Program, Weill Cornell MedicineLeave a comment on Global Collaboration: Lymphoma Researchers Attend Workshop at Shanghai Institute of Hematology


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Q: JQuery Flot doesn't draw bar chart + how to display values from data in tooltip? I have a problem with JQuery Flot chart. It doesn't show the bar chart (data_campaigns) at all but the (data_campaigns2) shows up just fine.
I would also like to know how to show data from both charts in tooltip. Now the tooltip is just showing random X and Y variables but I would like it show the amount of clicks.
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[1360458000,9],[1360544400,6],[1360630800,13],[1360717200,12],
[1360803600,6],[1360890000,13],[1360976400,3],[1361062800,9],
[1361149200,18],[1361235600,18],[1361322000,12],[1361408400,14],
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[1360803600,6],[1360890000,13],[1360976400,3],[1361062800,9],
[1361149200,18],[1361235600,18],[1361322000,12],[1361408400,14],
[1361494800,7],[1361581200,5],[1361667600,3],[1361754000,9],
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        }

 });

        function showTooltip(x, y, contents) {

            console.log(x+","+y);

            var d = new Date(contents *1000);
            var curr_date = d.getDate();
            var curr_month = d.getMonth();
            curr_month++;
            var curr_year = d.getFullYear();

            $('

'+curr_date + "." + curr_month + "." + curr_year+'<\/div>
'+x+'%<\/div>
CTR<\/div>
'+y+'<\/div>
Clicks<\/div><\/div>').css( {
                position: 'absolute',
                display: 'none',
                top: y - 125,
                left: x - 40,
                border: '0px solid #ccc',
                padding: '2px 6px',
                'background-color': '#fff',
                opacity: 10
            }).appendTo("body").fadeIn(200);
        }

        var previousPoint = null;
        $("#placeholder").bind("plothover", function (event, pos, item) {
            $("#x").text(pos.x.toFixed(2));
            $("#y").text(pos.y.toFixed(2));
            if (item) {
                if (previousPoint != item.dataIndex) {
                  previousPoint = item.dataIndex;
                  $("#tooltip").remove();
                  var x = item.datapoint[0].toFixed(2),
                  y = item.datapoint[1].toFixed(2);
                  showTooltip(item.pageX, item.pageY,
                    x);
              }
          }
      });

A: 1) the x, y parameters in function showTooltip(x, y, contents)
are actually not x,y values from your chart, bude x, y coordinates where to place the tooltip at. The tooltip value (text displayed in tooltip) is in parameter contents, so instead of:
$('

'+curr_date + "." + curr_month + "." + curr_year+'<\/div>
'+x+'%<\/div>
CTR<\/div>
'+y+'<\/div>
Clicks<\/div><\/div>').css( {...

you need something like this:
$('
' + contents + '<\/div>').css({...

with contents variable filled with whatever you need.
2) you need to set mode option
xaxis: {
    mode: 'time',
    ...
}

and play a bit with the options to display bars. in the jsfiddle example below i set the lineWidth: 10 and changed some colors
3) Blake's advice about the timestamps is right. (not solving the bar visibility, but solving the correct x axis date values), when populating the data array, multiply them by 1000 to be displayed correctly
here is the jsFiddle, have a look at it