基督既在肉身受苦,你们也当将这样的心志作为兵器,因为在肉身受过苦的,就已经与罪断绝了。 Therefore, since Christ suffered in his body, arm yourselves also with the same attitude, because he who has suffered in his body is done with sin.
你们存这样的心,从今以后就可以不从人的情欲,只从 神的旨意,在世度余下的光阴。 As a result, he does not live the rest of his earthly life for evil human desires, but rather for the will of God.
因为往日随从外邦人的心意行邪淫、恶欲、醉酒、荒宴、群饮,并可恶拜偶像的事,时候已经够了。 For you have spent enough time in the past doing what pagans choose to do--living in debauchery, lust, drunkenness, orgies, carousing and detestable idolatry.
他们在这些事上,见你们不与他们同奔那放荡无度的路,就以为怪,毁谤你们。 They think it strange that you do not plunge with them into the same flood of dissipation, and they heap abuse on you.
他们必在那将要审判活人死人的主面前交账。 But they will have to give account to him who is ready to judge the living and the dead.
为此,就是死人也曾有福音传给他们,要叫他们的肉体按着人受审判,他们的灵性却靠 神活着。 For this is the reason the gospel was preached even to those who are now dead, so that they might be judged according to men in regard to the body, but live according to God in regard to the spirit.
万物的结局近了,所以你们要谨慎自守,警醒祷告。 The end of all things is near. Therefore be clear minded and self-controlled so that you can pray.
最要紧的是彼此切实相爱,因为爱能遮掩许多的罪。 Above all, love each other deeply, because love covers over a multitude of sins.
你们要互相款待,不发怨言。 Offer hospitality to one another without grumbling.
各人要照所得的恩赐彼此服侍,作 神百般恩赐的好管家。 Each one should use whatever gift he has received to serve others, faithfully administering God's grace in its various forms.
若有讲道的,要按着 神的圣言讲;若有服侍人的,要按着 神所赐的力量服侍,叫 神在凡事上因耶稣基督得荣耀。原来荣耀、权能都是他的,直到永永远远。阿们! If anyone speaks, he should do it as one speaking the very words of God. If anyone serves, he should do it with the strength God provides, so that in all things God may be praised through Jesus Christ. To him be the glory and the power for ever and ever. Amen.
亲爱的弟兄啊,有火炼的试验临到你们,不要以为奇怪(似乎是遭遇非常的事), Dear friends, do not be surprised at the painful trial you are suffering, as though something strange were happening to you.
倒要欢喜,因为你们是与基督一同受苦,使你们在他荣耀显现的时候,也可以欢喜快乐。 But rejoice that you participate in the sufferings of Christ, so that you may be overjoyed when his glory is revealed.
你们若为基督的名受辱骂,便是有福的,因为 神荣耀的灵常住在你们身上。 If you are insulted because of the name of Christ, you are blessed, for the Spirit of glory and of God rests on you.
你们中间却不可有人因为杀人、偷窃、作恶、好管闲事而受苦; If you suffer, it should not be as a murderer or thief or any other kind of criminal, or even as a meddler.
若为作基督徒受苦,却不要羞耻,倒要因这名归荣耀给 神。 However, if you suffer as a Christian, do not be ashamed, but praise God that you bear that name.
因为时候到了,审判要从 神的家起首;若是先从我们起首,那不信从 神福音的人将有何等的结局呢? For it is time for judgment to begin with the family of God; and if it begins with us, what will the outcome be for those who do not obey the gospel of God?
若是义人仅仅得救,那不虔敬和犯罪的人将有何地可站呢? And, "If it is hard for the righteous to be saved, what will become of the ungodly and the sinner?"
所以,那照 神旨意受苦的人要一心为善,将自己灵魂交与那信实的造化之主。 So then, those who suffer according to God's will should commit themselves to their faithful Creator and continue to do good.


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Brief History of Modern Architecture
Architecture | 03 Dec 2022
A Brief History on the Beginnings of Modern Architecture
Modern architecture, or modernist architecture, was an architectural movement or architectural style based upon new and innovative technologies of construction, particularly the use of glass, steel, and reinforced concrete; the idea that form should follow function (functionalism); an embrace of minimalism; and a rejection of ornament.[1] It emerged in the late 19th Century and became dominant after World War I until the 1970s, when it was gradually replaced as the principal style for institutional and corporate buildings by postmodern architecture.
Modern architecture emerged at the end of the 19th century from revolutions in technology, engineering, and building materials, and from a desire to break away from historical architectural styles and to invent something that was purely functional and new.
The revolution in materials came first, with the use of cast iron, drywall, plate glass, and reinforced concrete, to build structures that were stronger, lighter, and taller. The cast plate glass process was invented in 1848, allowing the manufacture of very large windows. The Crystal Palace by Joseph Paxton at the Great Exhibition of 1851 was an early example of iron and plate glass construction, followed in 1864 by the first glass and metal curtain wall. These developments together led to the first steel-framed skyscraper, the ten-story Home Insurance Building in Chicago, built in 1884 by William Le Baron Jenney. The iron frame construction of the Eiffel Tower, then the tallest structure in the world, captured the imagination of millions of visitors to the 1889 Paris Universal Exposition.
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text:
Infectious Disease > COVID-19
COVID-19 Antibody Tests; Apgar Scores in Preterm Infants: It's TT HealthWatch!
— This week's topics also include triple inhaled therapy in COPD, and MIS-C following COVID-19 infection in kids
by Rick Lange, MD, Texas Tech; Elizabeth Tracey, Johns Hopkins Medicine July 5, 2020
TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center in El Paso, look at the top medical stories of the week. A transcript of the podcast is below the summary.
This week's topics include antibody testing for COVID-19, Apgar score utility in preterm infants, triple inhaled therapy in chronic obstructive pulmonary disease (COPD), and multisystem inflammatory syndrome in children (MIS-C) following COVID-19 infection in kids.
Program notes:
0:42 Looking at antibody tests for COVID-19
1:45 How sensitive are they?
2:45 Point of care most unreliable
3:43 Haven't been adequately validated
4:20 Apgar scores in preterm infants
5:20 1.8% mortality
6:20 Score of 10 is perfect
7:15 MIS-C
8:15 Average 8 years of age
9:15 Fever in 2 to 4 weeks
10:22 Triple inhaled therapy in COPD
11:23 Two combinations worked best
12:25 Some increase in pneumonia
13:24 End
Elizabeth Tracey: Can Apgar scores help us to identify at-risk preterm infants?
Rick Lange: The sequelae of COVID infection in children and adolescents.
Elizabeth: How about triple therapy in people with COPD?
Rick: And is antibody testing for COVID ready for primetime?
Elizabeth: That's what we're talking about this week on TT HealthWatch, your weekly look at the medical headlines from Texas Tech University Health Sciences Center in El Paso. I'm Elizabeth Tracey, a Baltimore-based medical journalist.
Rick: I'm Rick Lange, President of Texas Tech University Health Sciences Center in El Paso, where I'm also Dean of the Paul L. Foster School of Medicine.
Elizabeth: Rick, in light of current events, of course, I think that we should turn to some of the COVID material first. My personal fave would be in the British Medical Journal, a look at, "Hey, what about these antibody tests?"
Rick: Elizabeth, the title of this -- and it summarizes what they looked at -- it's called "The Diagnostic Accuracy of Serologic Tests for COVID-19." It's both a systematic review and a meta-analysis. I will remind our listeners is there's two types of tests for COVID. One is the antigen test. One gets a nasopharyngeal swab and looks for evidence of viral particles in that specimen and it would detect active infection. The second test is the antibody test. After someone has become infected, 1 to 2 weeks after that they begin to develop antibodies. Serologic tests identify somebody that has been infected. There are a number of antibody tests that are available. How reliable are they?
There are three different types of serologic testing: one called an enzyme-linked immunosorbent assay, called an ELISA, one called a lateral flow immunoassay, or an LFIA, or a chemiluminescent immunoassay, called a CLIA. What they discovered, first of all, is how sensitive they are -- that is, if you have it, are these tests sensitive enough to determine whether that's true or not? It ranged as low as 66% for the LFIA test to the highest of 97.8% in CLIA. Then they looked at also the specificity -- that is, if it says it's positive, is it truly positive? There was a variety among those as well.
Also, by the way, it determines on when you get the test. If you get the test within the first 2 weeks of infection, you're not likely to detect it. You have to wait for at least 3 weeks after the infection. In essence, what they concluded is that the current available evidence does not support continued use of existing point-of-care serologic testing.
Elizabeth: This is just such a big problem because we cannot confirm any of our assertions relative to, hey, who's had it, who's safe, who is not -- any of that -- if we don't have adequate testing.
Rick: Right, and what happens is they misclassify individuals. Their recommendations are -- and especially the ones that are really unreliable -- are those at point of care. As you walk in, they say, "We can give you an answer within minutes." Those are the most unreliable tests.
Elizabeth: And so, we were talking, of course, before we started to record about the FDA actually allowing all of these tests to get out there and just how inexplicable I find that. You, of course, were defending the agency.
Rick: What happened early on, as you know, there was not adequate testing. There were a number of companies that proposed tests, so the FDA gave emergency use authorization. It didn't say that they had validated the test, but in order to get the test out quickly, the FDA allowed that. But they made it clear they had not approved the test. Now that we're having more time to look back -- and that's what this study does -- it shows they're not as reliable as we'd like for them to be.
Had the FDA not done that and we had inadequate testing, people would be pointing a finger to the FDA and be saying, "Well, we have all these tests available. You're just not allowing the public to use them." I think what the FDA found was that middle ground, saying, "We'll allow it to be out there, but we can't endorse them because they haven't been adequately validated."
Elizabeth: If you were a betting guy, what would you say about when we're going to have validated tests that are going to have adequate sensitivity and specificity?
Rick: Elizabeth, I think that there are some on the market. Part of it depends upon what the prevalence is. The more people that have in the baseline population, the more likely a positive test really means it's positive. When the seroprevalence is very low -- that is a few people do -- you're more likely to have false positives. The tests are getting better. The trouble is most of the populace does not know which tests those are.
Elizabeth: More to come, no doubt. Let us totally flip gears. Let us go to the New England Journal of Medicine and take a look at this study that was looking at the utility of the Apgar score to help identify the risk of neonatal death among those babies who are born preterm.
This is a study that was conducted in Sweden and they identified 113,300 preterm infants from 1992 through 2016. Preterm was defined by 22 weeks to 36 weeks 6 days of gestation. That was further subdivided into 22 to 24 weeks, 25 to 27, 28 to 31, 32 to 34, and 35 or 36.
They performed Apgar scores on these infants at 5 and 10 minutes, and they also calculated the change in the Apgar score in that 5-to-10-minute assessment. There were 1,986 neonatal deaths, 1.8% of this group, of this cohort.
Here is what they showed. Not surprisingly, those infants who were earlier in that preterm group had a higher rate of mortality and that was pretty predictable. Then they also showed something interesting, which was an increase in the Apgar score between 5 and 10 minutes was associated with lower neonatal mortality than an Apgar score that stayed the same. So these authors say that this is really the first time that anyone has looked at this particular aspect of the Apgar score and tried to use it to prognosticate what a likely outcome for these infants might be.
Rick: For those of our listeners who may not know what an Apgar score is, it was developed by Dr. Virginia Apgar in the 1950s and it was a way to assess whether children would need to be resuscitated. She looked at five very simple things. When the child's born, you assess their heart rate, their respiratory effort, their muscle tone, their reflex irritability, and their color. They gave a score from 0 to 2 for each of those five things. So an Apgar score of 10 meant everything looked terrific.
That's clearly been shown to predict resuscitation and survival in normal term births. But the question is with preterms -- because reflexes may not be as good, their muscle tone may not be as good -- was the Apgar score still predictive? That's why this study was done. As you mention, Elizabeth, it does have prognostic value, but this is the first test to show it, especially in this large population. If the Apgar score is very low, 0 to 3 at 5 minutes and 10 minutes, the chance of meaningful survival, even in preterm infants, is extremely low.
Elizabeth: I also thought that it was very interesting, this idea that the change, if it improved over that time period, was also associated with an improved prognosis.
Rick: What that would mean is probably there were some measures taken between 5 and 10 minutes that the baby responded to, and if they do, any of those give things get better, it indicates the child will continue to improve.
Elizabeth: Let's turn back to our COVID material, this time in the New England Journal of Medicine, talking about children. What about that rare complication in children who are COVID-19 infected?
Rick: That rare complication you're referring to is called MIS or the multisystem inflammatory syndrome. For the most part, the acute complications are relatively rare in children. But what was noticed was that there were infants and adolescents who would develop infection and they'd be fine. Then about a month later, they would develop a multi-inflammatory syndrome characterized by high fever and evidence of inflammation in multiple organ systems.
There are two studies in the New England Journal of Medicine. One of them was conducted in New York City. The other is a surveillance that was done in pediatric health centers across the United States, the first one about 95 patients, and the second one 186 patients in 26 different states. Here's what they found out.
The vast majority of these kids either had active virus or antibody, more commonly antibody. The average age of individuals who got this MIS was 8 years old. They usually got it about 2 to 4 weeks after the active infection. It affected the GI tract in about 90% of individuals, the cardiovascular system in about 80% of kids and infants, the hematologic system in about 76%, mucocutaneous manifestations -- skin manifestations -- in 74%, and respiratory in about 70%.
It looks like it occurs in about 2 per 100,000 individuals under the age of 21. When it happens, the mortality is about 2%. About 80% of those kids end up in an ICU and about 20% on a ventilator, with only about 2% dying. Their average hospitalization is about 6 to 7 days.
Elizabeth: One of the things that I had heard about even previous to these two articles was the idea that if you have a child you suspect has had COVID-19 and they develop a rash, that that might be a time when you want to seek care, or at least assessment.
Rick: Right. In fact, even before then, Elizabeth, it looks like about 97% of these kids have a fever. So if the child has recovered from COVID manifestations and then 2 to 4 weeks later they develop a fever again -- or, again, GI symptoms, cardiovascular symptoms -- then the child needs to be brought to attention of the pediatrician.
By the way, it's a clinical diagnosis. There's no single test. But if you measured lab tests, you'd find markers of inflammation are very high -- they're through the roof -- and about 50% of these kids will have some heart manifestations as well, elevated troponin, for example.
These kids seem to recover from the acute events. Now, are there long-term sequelae? We don't know the answer. There does seem to be a higher prevalence in African American and Hispanic kids than there are in whites, for example, but there are many things that we just don't know about it yet.
Elizabeth: I guess the other thing I'm wondering about is the utility of dexamethasone in this population. Certainly, we don't have any data on that, but it seems like it would make sense.
Rick: Yeah. Elizabeth, I'm glad you mention this because almost all of these kids were treated with some sort of immunomodulating agents, whether that could be they get an immunoglobulin infusion, whether they get an interleukin inhibitor, or whether they get dexamethasone, or some combination. We don't know which works best, but the vast majority of these kids did receive some type of treatment for their inflammation.
Elizabeth: Staying in the New England Journal of Medicine, let's take a look at this population that internationally is growing all the time, and that's folks with chronic obstructive pulmonary disease or COPD.
It's taking a look at triple inhaled therapy at 2 glucocorticoid doses in folks who have this moderate to severe COPD. They used an inhaled glucocorticoid, a long-acting muscarinic antagonist, or LAMA, and a long-acting beta 2 agonist, a LABA. It's been studied previously at single doses, but this study takes a look at two doses.
The study took place over a year. It's a phase III study and randomized, included people with, as I said, moderate to severe COPD who had had at least one exacerbation in the previous year. There were four study groups. There were different combinations that were in each of these and I'm not going to go through every single one of them. The ultimate population that was treated was 8,500 patients plus and what they found was that the combination of either 320 mcg of budesonide or 160 mcg of budesonide, with all of these other meds, resulted in the best outcomes.
Rick: This is, I would say, kind of a moving target because the current recommendations are that there's kind of a stepwise approach that you start with one medication. If it doesn't work, you add a second medication. If it doesn't work, then you work your way to a glucocorticoid or a steroid. The reason why they reserve steroids to last is because inhaled steroids are associated with some complications, like pneumonia, bone fractures, and even cataracts.
What this study shows is that the use of triple therapy was more effective both at two things: at reducing exacerbations and improving mortality at the higher dose. That's the new swing. Because if you use two instead of three agents, you don't get the benefit of that.
Now, was there an increased risk of pneumonia? There was. It was a slight increased risk of pneumonia. Overall, it seemed to translate into an improved mortality in these individuals, again, with moderate or severe COPD.
Elizabeth: Another part of this that I thought was noteworthy was that over 80% of the patients at enrollment had already been on glucocorticoids previously and also the incidence of serious adverse events was about 20% in the people who were taking this therapy, any of these therapies.
Rick: Elizabeth, your point is well-taken because normally you wouldn't include people like that in a study because you think, "Well, maybe they wouldn't receive a benefit." But this study would suggest even if they have been treated otherwise that this triple therapy can still be beneficial in those individuals, so that's an important point.
Elizabeth: All right. On that note then, that's a look at this week's medical headlines from Texas Tech. I'm Elizabeth Tracey.
Rick: And I'm Rick Lange. Y'all listen up and make healthy choices.


Here's a sneak preview of how a new gin and tea bar in Cheltenham is shaping up.
The Memsahib Gin and Tea Bar will be run from the old Prom Vaults nightclub in the Promenade .
The owners of award-winning Anglo-Indian Cheltenham restaurant East India Cafe are the team behind the venue, which will offer house-distilled gin, afternoon Chai tea and light snacks.
It will be opening in October.


Ever run into the problem of uploading a video to Facebook or YouTube and getting it stopped because of the music you've chosen? Here's a saturday tip: In the future. Pick music that is published under the Creative Commons licence. Find great sites over at Creative Commons own website here. My personal favorite is Free Music Archive.


The FREE Network Makes Global Connections!
The University of South Florida, The FREE Network, and community partners came together to explore challenges and opportunities in ending human trafficking and supporting survivors. End Human Trafficking: A Community Approach was a great opportunity to brainstorm solutions to this complex problem.


Nice opportunity for some rare items. Have used in my holiday display for several years. The item "Outdoor Christmas Blow Molds" is in sale since Saturday, September 29, 2018. This item is in the category "Collectibles\Holiday & Seasonal\Christmas\ Current (1991-Now)\Yard Décor". The seller is "fb_gene" and is located in Vernon-Rockville, Connecticut.


text:
Q: Add Empty/Null Option As First Option of HTML/Select Using php how can I add a Empty option, and set the field to required?  This is the current code
<div class="qu-field">
    <?php
        $label = new HTML\Label(__('Are you shipping FedEx Or UPS?', 'query-mailer'), [
            'for' => 'carroer',
        ]);
        $label->render();

        $input = new HTML\Select([
            'id' => 'carrier',
            'name' => 'carrier',
        ], [
            new HTML\Option([
                'value' => 'FedEx',
                'selected' => false,
            ], ['FedEx']),
            new HTML\Option([
                'value' => 'UPS',
                'selected' => false,
            ], ['UPS'])
        ]);
        $input->render();
    ?>
</div>

redpajama_set_name: RedPajamaStackExchange


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These are the books that I've read on Digital Marketing that I consider essential reading.
Don't Make Me Think, Steve Krug. This book is insanely helpful. Krug has a way of making seemingly complex topics super simple and easy to understand. He's a User Experience designer and that's the focus of the book, but it's essential that every Digital Marketer understand and consider the topics in his book.
Permission Marketing, Seth Godin. This is a classic. Godin lays out his theory of permission marketing and explains why Email is and will always be such a power marketing tool.
This is a collection of my favorite Digital Marketing videos. Some of them are very popular and have been shared millions of times, while the others a bit obscure.
http://www.ted.com Tipping Point author Malcolm Gladwell gets inside the food industry's pursuit of the perfect spaghetti sauce -- and makes a larger argument about the nature of choice and happiness.
http://www.ted.com Seth Godin argues the Internet has ended mass marketing and revived a human social unit from the distant past: tribes. Founded on shared ideas and values, tribes give ordinary people the power to lead and make big change. He urges us to do so.
http://www.ted.com Customers want to feel what they buy is authentic, but "Mass Customization" author Joseph Pine says selling authenticity is tough because, well, there's no such thing. He talks about a few experiences that may be artificial but make millions anyway.
http://www.ted.com In a funny, rapid-fire 4 minutes, Alexis Ohanian of Reddit tells the real-life fable of one humpback whale's rise to Web stardom. The lesson of Mister Splashy Pants is a shoo-in classic for meme-makers and marketers in the Facebook age.
John Gerzema says there's an upside to the recent financial crisis -- the opportunity for positive change. In this talk, he identifies four major cultural shifts driving new consumer behavior and shows how businesses are evolving to connect with thoughtful spending. (Filmed at TEDxKC.) Talk by John Gerzema.
These are the blogs that I read regularly. And if you're interested in staying up-to-date with Digital Marketing, you should too.
These are the Digital Marketing websites that I have bookmarked in my browser. I use most of them daily.
These are the events that I attend annually. It's a great way to meet other digital marketers and also possibly land a new job!
Get Started with Digital Marketing now.


Hollywood Medium star Tyler Henry was in Windsor Friday night for a packed house eager to hear about his stories and to witness his mentalist abilities first-hand. According to the medium-to-the-stars, The Colosseum audience was the largest crowd he'd ever performed for.
Henry took the crowd through his personal encounters with his clients, television show guests and how he actually discovered his psychic abilities. It seemed like the type of show that is designed more for a smaller, intimate audience, but the larger audience gave the controversial topic a little more weight.
He had the audience in tears as he told stories about his grandmother and best friend, both of which he had sensed their deaths before they had actually happened. He had also brought along a necklace that belonged to his grandmother that was tucked away into a box on a table in the middle of the stage. He told a story about seeing visions of that necklace, which ended up becoming one of the only remaining pieces of memorabilia left after his grandmother's home was robbed the day she died.
Henry is a very likeable guy who appears to enjoy connecting with people and helping them with closure or clarity as they move forward with their own lives. As he told his own story, it was clear that he struggled with his abilities early on, even waiting patiently for approval from his dad, who tested him one day.
After going through his personal stories and a brief explanation of how his physic abilities work, Henry opened the floor for questions from the audience. Although he suggested questions about how his abilities work or even some about the TV show, it ended up being a series of questions and shotgun queries about personal experiences or relatives that passed.
In one shocking moment, Henry answered one question about a husband that passed by fluttering his arms and jumping around the stage saying he saw a bird in a vision. It turns out that the woman who asked the question made the connection to a cardinal who keeps fly into her window. Whenever the bird hit the window, she would turn to her son and say 'that's your father'.
Henry's show was enjoyable, entertaining and educational. It even came with a clear message that self-awareness is the key to moving forward in life.
After the show, Henry invited the audience to join him for a book signing and photos, which created a long line of anxious fans in the Casino mezzanine.
Hollywood Medium returns to E! Canada on February 28 at 9pm for its third season, beginning with guests Jim Parsons (Big Bang Theory), Kristin Cavallari and Savannah and Todd Chrisley.