text:
Integrative Metabolism and Environmental Influences
Human Genomics and Metagenomics in Metabolism
Nutrient and Metabolite Sensing
Endocrine Regulation of Metabolism in the Juul Holst Group
The overarching aim of the group is to understand the functional challenges of obesity and type 2 diabetes and to provide new principles for improved therapies. The group is conducting state of the art research in the field of translational physiology and has excelled in developing experimental models and assays resulting in identification and development of drugs based on the hormones GLP-1, GLP-2 and GIP.
Our primary research area is the physiology of peptide hormones and neurotransmitters, particularly those related to pancreatic and gastrointestinal functions and signaling.
The group has excelled in developing experimental models and assays enabling us to measure the secretion and actions of metabolically active gut and pancreatic peptide hormones . Our analyses are founded on immunological and mass spectrometry-based approaches, and the implementation of both single cell approaches, isolated perfused organs, in vivo animal studies, and notably, extensive human studies. Group leader prof. Juul Holst explains; "We strive to translate our experimental work into effective clinical studies in order to understand the functional challenges of obesity and diabetes, and to provide new principles for improved therapies".
Examples of achievements since the establishment of our group at CBMR include:
"The exaggerated glucagon-like peptide-1 response is important for the improved β-cell function and glucose tolerance after Roux-en-Y gastric bypass in patients with type 2 diabetes"
Published in Diabetes in 2013. The clinical and experimental proof for the importance of GLP-1 for the remission of diabetes after gastric bypass.
"Insulin Secretion Depends on Intra-islet Glucagon Signaling"
Published in Cell Reports in 2019. An elegant demonstration of the important paracrine regulation of insulin secretion by intraislet glucagon.
"Paracrine crosstalk between intestinal L- and D-cells controls secretion of glucagon-like peptide-1 in mice"
Published in American Journal of Physiology - Endocrinology and Metabolism in 2019 Experimental proof for the paracrine regulation of intestinal GLP-1 secretion by somatostatin, providing background for the development of somatostatin-5-receptor antagonists for diabetes therapy.
The Juul Holst Group focuses on the following main research areas:
The endocrine pancreas
Regulation of secretion of insulin, glucagon and somatostatin including neural , metabolic and paracrine mechanisms with an emphasis on studies in isolated perfused pancreases from mice and rats with metabolic, pharmacological, and genetic modifications
The role of pancreatic and intestinal hormones in bone physiology
Focuses on pancreatic and intestinal hormones and their role in intestinal and bone physiology. This includes both animal (mice, rat and pig) studies as well as human studies (gastric bypass patients, diabetic patients and healthy controls). In addition, we are continuously working on assay development to improve our unique spectrum of assays for measuring gastrointestinal hormones.
Clinical translation of diabetes and obesity
Focuses on providing insights into the biological function in humans of the genes behind the strong genetic component of obesity and diabetes, as well as into the treatment potential. Clinically targeting these dysfunctionalities will, with time, improve the prevention, diagnosis and treatment of type-2 diabetes and obesity. Therefore, the overall aim is to clinically translate knowledge of rare genetic variants in genes encoding beta-cell and appetite regulating proteins into actions of personalised prevention, diagnosis and treatment of obesity and diabetes.
Metabolism and physiology of enteroendocrine hormones
Centers on the degradation and metabolism of the entero-pancreatic hormones (GLP-1, GLP-2, GIP, PYY, glucagon), the physiology and pathophysiology of the incretin hormones, and the therapeutic applications of the incretin hormones, GLP-1 analogues and DPP-4 inhibitors in the treatment of type 2 diabetes.
Integration of the gut in human glucose metabolism and its role in diabetes and obesity
Centers on the pathophysiology of type 2 diabetes (with focus on glucagon and the gut-derived incretin hormones), obesity, regulation of appetite and food intake and utilization of incretins as therapeutics. Our main focus is on integration of the gut (including enteroendocrinology, microflora and bile acid biology) in the understanding of human glucose metabolism and its role in type 2 diabetic pathophysiology.
Partners and Funding sources
Partners: Our group works in close collaborations with the Dept. of Endocrinology at Hvidovre University Hospital and Center for Clinical Metabolic Research, Gentofte Hospital and also with the Clinical Proteomics in the Mann Group at the Novo Nordisk Foundation Center for Protein Research.
Additionally, the group collaborates with numerous national and international collaborators.
Funding: Since its inception in 2010 the Juul Holst Group has been awarded numerous grants from the Novo Nordisk Foundation. The most recent grants being "A new understanding of Glucagon Physiology" and "Amino Acids and glucagon constitute an endocrine feedback loop - The liver-alpha cell axis".
In 2015 Professor Juul Holst was awarded an advanced grant from the European Research Council for the project "Reaching the effects of gastric bypass on diabetes and obesity without surgery". The award funds research until December 31, 2021.
Jens Juul Holst
MD, Dr. med. Sci.
jjholst@sund.ku.dk
Andersen, Daniel Bjørklund PhD Student Juul Holst Group, Endocrine Regulation of Metabolism +4535337499 E-mail
Constantini, Tabatha Emilia de A External Juul Holst Group, Endocrine Regulation of Metabolism E-mail
Holst, Jens Juul Professor Group Leader, Juul Holst Group, Endocrine Regulation of Metabolism +4528757518 E-mail
Lehmann, Jule Helen Glaser Academic Officer Juul Holst Group, Endocrine Regulation of Metabolism +4591855193 E-mail


Best entree at First Watch! You must get extra of the Vera Cruz sauce! Seriously so good. Service is always great and fast.
Seriously the best waffle ever! The strawberry compote was also a nice addition. Always enjoy my meals at First Watch!
I'm not a fan of truffle... or mushrooms... but WOW!
Always a go-to at First Watch!
Wasn't feeling a lot to eat and this was sweet, tart, and perfect!
Hands down, the. best. special. on. the. menu.
Throwback to this weekend. One of our favorite orders from the menu!


Go Auto is comprised of 40+ dealerships, multiple repair and service centers, several reconditioning facilities, in-house finance and insurance departments, a loyalty and rewards program, and more.
...there was the Mike Priestner Auto Group (MPAG). Mike began his journey back in 1996 with the purchase of Kentwood Ford. Many years have since passed, and Kentwood Ford has continued to be the backbone of our business. Two years later, MPAG acquired Peace River Ford, its second Ford dealership, and first dealership outside of Edmonton.
MPAG purchased Edmonton's Southtown Chrysler, and with that purchase, MPAG welcomed three noteworthy brands into its business: Chrysler, Dodge, and Jeep.
At the turn of the new millennium, MPAG purchased two additional dealerships. It added its very first import branded store, Southtown Hyundai, as well as a second Edmonton Ford dealership, Team Ford.
Focusing on domestic makes, MPAG acquired Yellowknife Chrysler in the Northwest Territories, Nelson Ford in British Columbia, and St. Paul Dodge, which is located approximately two hours east of Edmonton.
Land Rover Edmonton, now Jaguar Land Rover Edmonton, joined the MPAG. Jaguar, our second luxury brand, would have to wait another three years to join the group.
In 2006, MPAG acquired Columbia Chrysler, located in Richmond, BC, our first Vancouver store. It was the fourth Chrysler, Dodge, and Jeep location and the 10th dealership to join the group.
MPAG added its second import brand, Kia, with the addition of Southtown Kia, located in Edmonton. It also added its second Edmonton Hyundai location, Northstar Hyundai, as well as its second Peace River dealership, Peace River Chrysler. Last, but not least, Capital Ford, located in Dawson Creek, British Columbia, was also acquired.
MPAG joins forces with the Ericksen Auto Group to form Go Auto, one of Canada's largest dealership networks, with 20 locations selling both new and used vehicles. The combination with Ericksen Auto Group brought two additional luxury brands and three new import brands: Infiniti, Porsche, Mazda, Nissan, and Volkswagen.
The group, now Go Auto, added Ericksen Infiniti, Porsche Centre Edmonton, Weber Mazda, Ericksen Nissan, and Norden Volkswagen. Go Auto, with 12 locations in Edmonton, finally had the size and scope to change the industry for the better.
Thanks to our success, we were able to create an in-house finance company, Go Finance. With Go Finance, we no longer need the banks to approve our customers for loans and leases. We can afford to lend the money ourselves. This has led to the highest rate of approvals in the Western Canadian auto market.
Go Auto added two Honda stores, Go Honda and Edson Honda. It also acquired TIG insurance, which was renamed Go Insurance. We sell Auto, Home, Travel, and Commercial insurance, and in many cases, have agents in our dealerships who can provide quotes and write policies on the spot.
With Go Insurance, Go Auto became a true one stop shop. We opened the Go Auto Outlet, our first location that specialized in used vehicles. We also acquired Strathcom Media, an automotive focused marketing agency that specializes in online advertising, inventory syndication, and dealer websites.
Go Auto opened its first Red Deer based used car dealership, Go Auto Direct Red Deer. Additionally, two RV & Marine locations were opened, one in Edmonton, and the other in Red Deer. Lastly, in 2012, we became the major Nissan player in Edmonton with the additions of Go Nissan North and Go Nissan South.
Go Auto purchased three new Red Deer locations, adding two additional luxury brands, Acura and Lincoln, and our 20th brand. We established a large presence in Red Deer, with the additions of Acura of Red Deer, Honda Red Deer, and MGM Ford Lincoln.
In Edmonton, we obtained our second Infiniti dealership: Infiniti South Edmonton. Klondike Cycle, a store specializing in cycling and hockey equipment, was added to the group. It was the first time Go Auto extended itself outside the automotive industry.
With success came the opportunity to give back to those who helped us make us what we are today. Go Auto is proud to contribute to organizations that help hundreds of thousands of Canadians each year.
In 2014 (and again in 2017), as part of our Random Acts of Kindness initiative, Go Auto gave $1 million to its employees with the condition that the money be used to help those in need. Each employee donated $350 to a person or group in genuine need, on behalf of Go Auto. Go Auto also acquired a second Vancouver location: Go Dodge Surrey.
Go Auto purchased Aurora Ford dealerships in Hay River and Yellowknife, NWT. In Alberta, we added Spruce Grove Hyundai, our third Hyundai dealer in the Edmonton area. We added our very first Toyota location, Drayton Valley Toyota, as well as our third RV location, Go RV Red Deer.
Go Auto made its first expansion east of Alberta in 2016 by purchasing Jaguar London, Land Rover London, and Volvo London (our 21st brand), all located in London, Ontario. In Red Deer, we purchased Go Dodge Red Deer, and in southern Edmonton, we opened the Go Auto Outlet South.
We added two dealerships and two new business units in 2017. The addition of Go Dodge Mississauga and Whiteoak Ford gave Go Auto a domestic vehicle presence in the Greater Toronto Area.
Meanwhile, in Edmonton, Go Mortgages and Yes Plan Financial were established. Go Mortgages, a mortgage broker center, provides home financing alternatives to Albertan homeowners and buyers. Yes Plan Financial specializes in financing mortgages and new and used car loans.
Unfortunately, one out of five children in Canada do not have a secure source of food. Go Auto will be providing over 61,000 hot lunches to Edmonton area schools. This will help ensure that these children will have one healthy meal, which has been proven to improve test scores, reading skills, attendance records, and overall health.
Go Auto also acquired a second Chrysler, Dodge, and Jeep location: Go Dodge Don Mills in the Greater Toronto Area. Go Auto has sold over 300,000 vehicles in its history. We've also repaired over 500,000 vehicles, financed over 200,000 drivers, and insured tens of thousands.
In November 2018, we were named one of Canada's Most Admired™ Corporate Cultures. This national program, presented by Waterstone Human Capital, annually recognizes best-in-class Canadian organizations for having cultures that enhance performance and help sustain a competitive advantage. Organizations were judged on six categories: vision and leadership, recruitment and hiring for fit, cultural alignment and measurement, retention, rewards and recognition, organizational performance and corporate social responsibility.
In addition to our first-class compensation, benefits, and employment opportunities, we were recognized for our strong promote-from-within philosophy. We also regularly contribute to organizations that help hundreds of thousands of Canadians each year. Not only did we give $1 million to our employees to be used towards the Random Acts of Kindness in their communities, but our staff members also volunteer every week for Go Auto Fuels the Schools, a program that delivers food to underprivileged schoolchildren across Edmonton.
Go Auto's full-time Employee Experience team organizes annual meet and greets with the Edmonton Oilers, Corporate Challenge events, expenses-paid trips for top performers, a 20-dealership BBQ tour catered by Go Auto's in-house kitchen team (led by a Red Seal chef), and an employee lunch program that makes 1,200+ meals every week.
In March 2019, Go Auto was named one of Canada's Best Managed Companies by Deloitte, one of the country's leading business awards programs that recognizes Canadian-owned and managed companies for innovative, world-class business practices. Winning companies demonstrated exceptional, sustained business performance through clear strategy, investment in current and future capability, and a steadfast commitment to hiring and retaining the best talent.
Go Auto was recognized for its customer-focused approach, ethical leadership, and industry-leading corporate culture. With 9,500 vehicles available from 19 brands, Go Auto offers the largest selection in Western Canada. Through innovation and productivity, the company has been able to thrive during the recent economic downturn, in no small part to the commitment shown to, and by, its employees. Go Auto was recognized in 2018 for having one of Canada's Most Admired Corporate Cultures.
The Best Managed Companies program is unique in that it focuses on Canadian owned and managed companies, recognizes overall business performance and sustained growth, measures more than just financial performance, and recognizes the efforts of the entire organization.


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This paper was a great failure, and I am ashamed of it.
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Home 0Recent Headlines Former Aurora Deputy City Attorney George Zierk dies at 66
0Recent Headlines
Former Aurora Deputy City Attorney George Zierk dies at 66
Deputy city attorney for the city of Aurora, Colo., George Zierk, throws out the ceremonial first pitch as part of a promotion about Lou Gehrig's disease before the Los Angeles Dodgers face the Colorado Rockies in the first inning of a baseball game in Denver on Friday, July 4, 2014. Zierk died from complications with ALS on June 18, 2019 (AP Photo/David Zalubowski)
George Zierk
George Zierk and his wife, Doreen.
AURORA | Longtime Aurora Deputy City Attorney George William Zierk III died June 18, 2018 from complications with ALS. He was 66.
Arrangements for Mr. Zierk are being handled by Newcomer Denver. A memorial service is scheduled for 2 p.m. June 30 at Christ Lutheran Church 3290 S Tower Road.
Mr. Zierk was a longtime city attorney and prosecutor for Aurora, serving for years as chief of the criminal attorney division.
He was a well-known and affable quantity at city hall.
READ EDITOR DAVE PERRY'S FEATURE ABOUT ZIERK AND ALS
Mr. Zierk was diagnosed with ALS in 2013 and continued working with the city in several capacities for years after his diagnosis.
"He will be greatly missed by everyone who had the honor of knowing him," Aurora Councilman Charlie Richardson said in a message to city officials. Richardson work with Mr. Zierk as city attorney for many years. "He continued to contribute his knowledge and wisdom to the Aurora City Attorneys Office until he could no longer leave his home."
Mr. Zierk was also an activist for the disease that took his life, working frequently with the Rocky Mountain Chapter of the ALS Association.
Mr. Zierk was born July 11, 1952 in Racine, Wis, the son of George and Dorothy Zierk. Mr. Zierk graduated Lake Forest High School in Lake Forest, Ill. He received a bachelor's degree from CU Boulder and received his Juris Doctor from William Mitchell College of Law in St. Paul, Minnesota. He was a law exchange student at Queen's College in Cambridge, England.
Mr. Zierk married Dorene Jensen Aug. 19, 1978.
Mr. Zierk was a founding member of Peace With Christ Lutheran Church in Aurora. He was a member of the Colorado Bar.
During his legal career, he was recognized to argue cases before the United States Supreme Court. He held the position of Aurora Deputy City Attorney until his recent retirement.
Mr. Zierk was a Boy Scout leader and involved in many sports as a baseball, soccer and flag football coach.
Mr. Zierk was remembered as an avid golfer, and he enjoyed Colorado outdoor passions like skiing, hiking, as well as world travel.
Mr. Zierk is survived by his wife, Dorene Zierk; daughter, Katelyn Fanning; son, JT "Jordan" Zierk; grandchild, Reese Fanning; and four siblings.
Memorial contributions may be made to Rocky Mountain Chapter, ALS Association, 10855 Dover St. Suite 500, Westminster, Colo. 80021.
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Sesame, cinnamon and red pear blend in harmony in this delicious and unique muffin.
I've been on a bit of a tahini streak lately (is that a thing?). First I made black tahini, then green tahini, drizzled tahini onto an awesome sub, added it to chocolate chip cookies and banana bread, used it to garnish and flavor guacamole stuffed mushrooms – and now this: A moist, super sesame-flavored muffin, with caramel notes from the dark brown sugar and baked red pear, and a crunchy cinnamon and sesame topping.
It's different, it's delicious, and if you like tahini (or are crazy over it, like moi), this one's for you.
Preheat oven to 350. Line large cupcake pans with paper liners, and spray with non-stick spray.
In a large bowl, whisk together flour, brown sugar, salt, cinnamon and baking powder.
Add egg, milk, oil and tahini and stir just until barely incorporated – there should still be lumps of flour.
Add in diced pear, and mix gently using just a few strokes (overmixing will yield rubbery muffins).
Mix sesame seeds, turbinado sugar and cinnamon. Sprinkle over muffin tops.
Bake 25-28 minutes, or until tops spring back when lightly pressed.
Transfer to wire rack to cool. Can be frozen once they are completely cooled.


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Monotypes are paintings on smooth acrylic plates transferred to paper once only.
spontaneous and evocative range of drawing, painting, and printmaking.
June 3-6, 2019, 9-12 noon $175.
Supply list sent with registration. Payment by check, or charge with Square One.
The natural world is a sanctuary, a place to breath wind and think and feel, undistracted at last. Things in nature transmute, a serene refuge of the spirit one day, drastically altered moments later. To paint on location is to create portraits of these familiar places, where ocean meets land, where hill meets sky.
Capture the fragility and wildness of nature with paint on canvas, meeting four days in early June. Choose your own specific subject matter and capture an authentic and enduring moment in time. Daily demos and one-on-one instruction throughout the morning.
Students create painterly spontaneous images on acrylic plates using small rubber brayers, brushes, Oil Bars, or stencils, and oil base etching ink. Dampened 100% rag paper placed on top of the inked plate, and passed through the press with gentle pressure, results in a unique impression that is intimately and permanently bonded with the fibers of the paper. Overprinting and contemporary experimental approaches with larger rollers produce magical surprises. The glistening layers of radiant ink create truly unique images with depth, mystery, memory, and delight. Demonstrations each day will help to develop individual explorations. Beginner to advanced students are welcome.


Tired of the same old blues licks in the pentatonic scale? In this series of lessons, I will try to broaden your horizons by introducing you to some elements from "exotic" territories like Middle Eastern, East European and Far Eastern music.
Is it D# or Eb?
As you might know, the minor blues scale has that unique note that distinguishes it from the pentatonic scale (the augmented 4th or diminished 5th).
In A minor blues, for example, it's Eb or D# (They are enharmonic tones, same pitch, different names).
But when should we call it the first or the latter—and what's the difference? Well, there are a few answers. One of them relates to their different functionality: While Eb can be an alternative to the 5th (E) by flattening it, D# can function as a leading-tone to the 5th.
In the first phrase (bars 1-2), I used Eb, which replaces E in a pull-off descending effect of a blue note (a well-known musical sigh). In the second phrase (bars 3-4), I used D# as a stepping stone toward E, which emphasizes the 5th in the Am chord. While these are still bluesy, the third phrase (bars 5-6) has a bit more spice and sounds more exotic by using D# with an augmented 2nd interval (C-D#). By adding B from the natural minor scale and drizzling some "HP sauce" on top of them (HP = hammer-on, pull-off), we're starting to get somewhere else.
The first phrase in EXAMPLE 3 (bars 1-2) includes a blues lick, and the next two versions use the same contour but with "Hungarian" alterations. In both, the notes A, C and E keep the Am chord triad; D and G are a half step higher; and the two additional notes—B and F—spice it up with some extra seasoning. It would be great to hear your take on this. You can use the following backing track and reply with your own licks.


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Biofuel challenges: Some green fuels can become contaminated with the wrong microbes
Tuesday, October 02, 2018 by: David Williams
Tags: air force, biocontamination, biodegradation, BioFuel, fossil fuel, fuel contamination, green fuels, microbial fuel fouling, renewables
(Natural News) Biofuel is seen as a promising alternative to fossil fuels when it comes to serving as a viable source of energy, and for good reason. It offers a number of tremendous benefits, not the least of which is the fact that it's much more environmentally friendly than current standard fuels. For this reason, its adoption is being pushed heavily and it's seen as the future in places such as the U.S. Air Force.
The problem is that there are difficulties that are present along the path to success of biofuels. Case in point: New research has shown that harmful microorganisms seem to thrive on biofuels, particularly on their fatty acids, and after a while they end up causing everything to turn into a slimy, unfixable mess.
This phenomenon, which has been supposedly known to many experts on the subject as microbial fuel fouling, is a type of fuel contamination wherein certain microorganisms can lead to huge problems if left untreated. In the case of the air force, their problems here could lead to clogged or fouled equipment, or worse, engine failure. You can imagine how big of a problem that would be.
According to Frederick J. Passman, biocontamination of fossil fuels is not uncommon at all. "Biodeterioration of fossil fuels has been known and studies for more than a century," he explained. As a consultant who specializes in controlling microbial contamination, he is an expert on the subject that has a clear view on it. (Related: Dead zone-forming algae could be used to enrich soils and produce biofuel, say scientists.)
It is said that the earliest study on the matter was first published some time in 1895, and it focused on the biocontamination of gasoline. And then most of the follow-up studies on it were published in the microbiology literature, instead of "the sort of journals likely to be read by petroleum engineers and organic chemists," added Passman.
Meanwhile, Wendy J. Goodson, a lead researcher at the Air Force Research Laboratory (AFRL) at Wright-Patterson Air Force Base in Ohio, is closely studying the effects of microoorganisms on the current crop of Air Force weapons systems and fueling infrastructure. She is working closely with a number of collaborators who are looking to fully understand fuel biocontamination's effects, the factors that promote it, and better ways of detecting and countering it.
According to Goodson, fuel maintenance specialists were already aware of biocontamination due to certain microorganisms, but that it was treated pretty much as a non-issue which "resided in the background of people's knowledge and concern." Now that it has been recognized as a real problem, perhaps it can finally be addressed properly.
One potential key to unlocking the solution to this problem is a surprisingly common element of life on Earth. Evidently, the one thing that plenty of cases of biocontamination of fuels have in common is none other than water. Indeed, as Passman remarks, it's for a simple reason: Water is a known essential factor for microbial activity. Current method of prevention for its accumulation in fuel systems is difficult, but perhaps it could aid in the prevention of biocontamination.
Oscar N. Ruiz, a biologist that also works in the AFRL, is of the opinion that biocontamination is a problem that needs to be "cured" like a sickness. In his own words, "This type of biodegradation is like a fuel disease." In other words, like any other disease, all it ultimately take to end up is finding the right type of "medicine," and they are working to find it.
Learn more about other problems in the search for alternative energy sources at Power.news.
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https://www.naturalnews.com/2018-10-02-biofuel-challenges-some-green-fuels-can-become-contaminated-with-the-wrong-microbes.html
Biofuel challenges: Some green fuels can become contaminated with the wrong microbes


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Cities: Skylines Review
Home / Cities: Skylines Review
by Excelle | PC | 0 Comments | 28 Mar 2015
If you haven't heard about Cities Skylines yet, Cities Skylines is a new sim game released by Paradox Interactive and developed by Colossal Order. Sound familiar? Colossal Order developed Cities in Motion back in 2011. Yes, the transpo sim game. Now, it seems like they have made a huge leap forward and applied their skills from Cities in Motion (and some say, they even applied reviews from other city sim games) and created an awesome new city-building simulation game and dubbed it Cities Skylines.
Released in Steam last March 10, Cities Skylines is seeing record sales for the publisher and even versus other sim games in the market. In fact, Cities Skylines reached a whopping 250,000 I-must-have-it-take-my-money clicks on Steam within the first 24 hours of its release.
The game is USD29.99 for the standard pack. The deluxe edition costs USD39.99 and for an additional USD10, you get five cool landmarks your citizens will like: the Eiffel Tower, the Arc de Triomphe, Brandenburg Gate, the Statue of Liberty, and Grand Central Terminal. The deluxe edition also has additional soundtracks for zoning out and really tripping while building your city.
PC, Apple, and Linux users are all going to have a blast with this sim game with reasonable required specs like 6GB of RAM and just 4GB of space needed. The video card requirements are nothing outrageous. So if your computer already plays other recent 3D games, it'll be able to play Cities Skylines as well.
Now on to the nitty-gritties! The game visuals are fantastic. The buildings are smooth and realistic — in a cartoonish kind of way. It sound ironic but the graphic style works for the game. Zooming in and out from an individual house to a city does not cause any lag with the recommended graphics specifications. The visual appeal of the game is exciting as you get caught up with little details such as a random bison grazing on a citizen's lawn.
In terms of sounds, the background music is pretty average but you can get 14 more tracks with the deluxe edition. The dashboard mouse click and building sound effects are also average but is satisfying enough for the feel of getting things done in the game.
The interface is reminiscent of a popular sim game. Everything is visually simple: just icons such as a lighting bolt for electricity and a water droplet for — you guessed it — water! Pop-up windows appear once in a while to give you, the mayor, tips and also to announce game achievements. There is still a bit of a learning curve and depending on your OCD level, you will find yourself deleting a whole day's urban development if your power lines aren't lining up exactly. A sim game newbie will have a bit of a challenge with the Cities Skylines dashboard but it would take him or her only 10 minutes or so to figure it out. Easy peasy!
The gameplay of Cities Skylines is what all the fuss in the reviews is about. And when you get into the game, you will realize that at last, this is the game you wanted EA to deliver but never did (Hello, EA!). The game feels HUGE, giving the player the ability to make a million citizens happy. Everything is seamless with fully simulated population reacting to your decisions on electricity, water supply, garbage collection, city districts, and roads. Details like power source, airflow, and water flow are all integrated into the game for a more realistic feel in building an efficient city. To add to that already awesome fact, the gameplay can be further enhanced by the developer's addition of a mod feature.
Colossal Order has embraced the curious and creative gamer by opening Cities Skylines to those who have developed mods to the game via a full Steam Workshop Integration. Can anyone say, "Open all the spaces!?" Then get the "All Spaces Unlockable" mod. There's also an essential mod — an Autosaver — that will save your work at a set regular interval. There are out of the box mods, too, such as unlimited money (which is the all-time favorite) and unlocking all buildings. (As a side note, the genius behind Colossal Order's mod feature is game replayability and variety for the gamer.)
Cities Skylines is a must-buy and must-have if you are one of those gamers who have been patiently waiting for years for that perfect city simulation game that will satisfy your need for straight roads and perfectly symmetrical urban and suburban districts. It's also good to know that Colossal Order is poised to give this game full support and maintenance for a long time, with plans of releasing regular patch updates and new episodes downloadable for a fee.
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