After making dozens of ice cream and sorbet pints in our quest to find the best ice cream maker and testing six highly rated machines, we decided that the Whynter – ICM-200LS Ice Cream Maker is the champion in churning out the rich and creamy treats you'd expect from a top-quality ice cream shop. Our runner-up choice is the Cuisinart – ICE-100 Ice Cream and Gelato Maker.
It's said that Thomas Jefferson introduced ice cream to the young United States and since then it's certainly become an American obsession. With hundreds of flavors sold in supermarkets and ice cream parlors, ice cream machines have come a long way since the good ol' days of churning it by hand with pounds of ice and rock salt.
We began our research by going through articles about the art and science of ice-cream making, including IceCreamScience.com, the American Chemical Society, Cook's Science and Serious Eats. We then consulted chefs from three upscale restaurants in Los Angeles (The World Famous Magic Castle, Mare and Farmshop). In Vancouver, we sought out our colleague James Coleridge of Bella Gelateria. Maestro James — as he's called — is the first non-Italian to earn a degree from the Carpigiani Gelato University near Bologna, Italy.
Once we learned the basics of how ice cream is made, we moved on to researching what home ice cream makers are available. A number of websites that specialize in ice-cream making also recommend the machines they prefer to use. We also read through Wirecutter's take, which tested 14 ice cream machines.
The Sweet Home concluded that after testing automatic ice-and-salt ice cream makers, freezer bowl models and compressor (self-refrigerating) models, the most convenient style of machine that also delivers a rich and creamy product is the compressor model. The Sweet Home also acknowledges that the compressor models are pricey and the freezer bowl-style is better for the budget-conscious consumer. For their final review, however, The Sweet Home focused entirely on compressor ice cream makers.
We also read through numerous customer reviews posted on Amazon. Many customers got great results from compressor models, but they were also pleased with freezer-bowl models and the automatic ice-and-salt machines. We decided to include each of these in our testing.
The leader in the industry is clearly Cuisinart. The company has several ice cream machines on the market that they upgrade every couple of years. However, there are several other American and European manufacturers who are giving Cuisinart a run for their money, so we included a few of these in our list of candidates to test.
Amazon reviewers state that an important reason for their buying an ice-cream machine is so they know what ingredients are going into the ice cream that they make. Other than flavoring, ice cream has only five ingredients: cream, milk, eggs (for custard-style ice cream), sugar and air.
Surprisingly, ice cream's total volume is composed of 30% to 50% air. A rule of thumb is that the cheaper brands of ice cream are pumped up with more air than the expensive brands. You can test this for yourself by holding a pint of, say, Haagen Dazs, in one hand with a pint of a generic supermarket brand in your other hand. The Haagen Dazs will be somewhat heavier than the cheaper ice cream since it is denser, and has less air.
The chemical formation of ice cream is similar to that of a salad dressing. They're both an emulsion, which is a combination of two liquids that aren't normally cohesive with each other; for example, oil and vinegar. Like with salad dressing, air is necessary to bring the two "unfriendly" elements together. In the case of ice cream it's fat (from cream and milk) and water (ice crystals), which serve to bind the ice cream together when it's frozen.
Air, however, is only one component. Ice cream also needs an emulsifier, which stabilizes the fat and ice crystals to give the ice cream a smooth and creamy texture. The most common emulsifier in ice cream is egg yolks. This type of ice cream is called custard or French style; without eggs, the ice cream is called Philadelphia style. The difference of adding egg yolks is most dramatic between French Vanilla (yellow and rich-tasting) and regular Vanilla (white with vanilla flavor more prominent).
Almost all store-bought ice creams that aren't custards use stabilizers such as guar gum, locust (or carob) bean gum, xanthan gum (which you'll also find in toothpaste) or carrageenan (derived from seaweed). Each of these is a thickening agent and serves the same purpose as egg yolks in chemically binding the other ingredients.
Our chef-consultants revealed that most ice-cream parlors — even ice-cream artisans — and restaurants use a pre-mixed ice cream base manufactured by a dairy distributor, such as Nestle or Hood, which the ice cream shop flavors and customizes.
These commercial bases combine, water, fat, sugar, milk solids and emulsifiers. They are then homogenized and pasteurized to prevent foodborne illness, as required by the U.S. Food and Drug Administration for the legal sale of commercially produced ice cream. Although a few countries in the EU continually fight restrictions on raw-milk cheeses, which can be substantially more flavorful that pasteurized cheese, we could not determine whether there is an EU manufacturer that makes ice cream with raw milk or cream.
We questioned several ice-cream companies (The Penny Ice Creamery, Salt & Straw, and a la Minute Ice Cream) about whether organic and locally sourced ingredients really affect the taste of the ice cream they make. Each company acknowledges their symbiotic business relationship with local dairy farmers and they all fervently believe their natural ingredients make better-tasting ice cream.
The experts agree that home ice cream machines aren't powerful enough to give professional results. They do offer tips, however, for making ice cream that closely approximates what you might purchase.
Sugar doesn't freeze, so it keeps ice cream soft. There is some leeway in the amounts of sugar you can use (for example, diminishing the recipe by ¼ cup), but unless you add some other ingredient that doesn't freeze (like alcohol), it's best to stick with the amount of sugar recommended in the recipe.
Corn syrup adds body and suppleness to the ice cream so it won't melt as fast. It also gives sorbets a smooth consistency.
Fat also doesn't freeze, but it's not necessary to use all cream for creamy ice cream. Whole milk or half-and-half can replace cream with very good results (gelato is made almost entirely with milk).
Corn starch will make a smooth and creamy ice cream without eggs. A small amount thickens the ice cream base into a custard-like consistency.
Churning time affects the airiness of ice cream. A commercial machine is powerful enough to churn ice cream in 10 to 15 minutes. A home machine doesn't have that kind of power, so it needs to churn longer, 35 to 50 minutes, to achieve a light consistency.
Generally, all ice cream made in a home machine needs to be frozen for at least two hours after it's been churned. This "resting period" gives the water molecules time to freeze and firm up the ice cream so it's easier to scoop.
At face value, an ice cream machine is a luxury item, but if you enjoy ice cream on a regular basis, it can actually be quite cost-efficient. An ice cream parlor charges around three dollars (or in the case of gelato, four dollars) for a single scoop and that's without any add-ins. A pint of Ben and Jerry's can set you back six or seven dollars. When you make your own ice cream, the cost for two quarts is about five dollars.
It may also be important to you to know exactly what's going into your ice cream, especially if you prefer to eat organic or have a food allergy. With a few of the machines we tested, we were able to reproduce ice creams and sorbets that tasted like those you buy at an ice cream parlor, but with less processed ingredients.
Today's compressor ice cream makers take ice and rock salt out of the picture altogether (except for the nostalgic, vintage-style machines), so homemade ice cream couldn't be easier. And let's face it, making ice cream is fun. Although we used the same recipes for all the machines during our testing, we couldn't wait to get creative and try out flavors and add-ins after the testing was completed.
Compressor style: Although compressor models are more expensive, in the long run, we found they couldn't be beaten in rapidly churning quarts of excellent ice cream in a short period of time. Compressor models are self-cooling, like mini refrigerator-freezers, so you don't need to pre-freeze the canister. Also, because the machine stays cold, you can churn out continuous quarts without waiting.
Freezer bowl style: A less-expensive alternative is a machine with a removable freezer bowl. The bowl is filled with a liquid gel that must be frozen in your freezer for at least 12 hours before you plan on churning ice cream. Although we could only churn two quarts of ice cream per day in the freezer bowl model, we did find that the freezer bowl did an efficient job.
Capacity: Three of the machines we tested had a 1.5-quart capacity, while two machines had a two-quart capacity. The ice-and-salt model, Hamilton Beach – 68330N had double the capacity at four quarts. For the compressor models, we found a 1.5-quart capacity sufficient, since we could make several quarts one after another. If you want to make more than two quarts in the Cuisinart – ICE-60W, you'll need to buy an additional freezer bowl.
Add-in spout: If you want to add in your favorite nuts and candy to your ice cream, then look for a machine with a spout. It's a convenient and practical feature, since removing the lid entirely during the churning process will lower the temperature of the ice cream and lengthen the time it takes to freeze.
Before we put the machines through their paces, we researched a number of tried-and-true ice cream recipes. Each of the instruction manuals for the machines included suggested recipes in chocolate and vanilla.
The basic recipes for vanilla custard ice cream were all pretty much the same. The manuals instruct that you can add any flavorings and add-ins like nuts, chocolate chips, caramel and pureed fruit into the base recipe.
Because these ice cream makers can also make sorbet, we tested that too. Sorbet is much easier to make and generally, the manuals offered simple sorbet recipes with pureed fruit, sugar and water. However, without a stabilizer, such as eggs, sorbet is grainy with ice crystals and melts too quickly. We researched recipes for sorbet and learned that light corn syrup works in a similar way to eggs and also makes sorbet smooth.
Fruit sorbet – We used the same sorbet recipe for all of the machines, but changed the fruit, using blueberry, raspberry, mango, peach, lemon and cherry.
The three ice creams all needed to be cooked to some degree. It's a crucial process for the vanilla custard ice cream, since the egg yolks need to heat to 170°F to kill the salmonella bacteria sometimes found in raw eggs. We also added cornstarch to the eggless chocolate ice cream to act as an emulsifier, so the mixture needed to be heated so the cornstarch could bind the cream and milk.
Ice cream churning in the Musso – Mini 4080 Lussino.
The best recipes we found for the vanilla custard ice cream and the eggless chocolate ice cream are by ice-cream guru David Lebovitz. However, we did switch out the condensed milk in the chocolate recipe for half-and-half. In some of the machines, the ice cream still churned out smooth, creamy and intensely chocolate.
Dairy-free coconut ice cream made in the Cuisinart – ICE-100.
For the dairyless coconut ice cream, we used equal parts coconut milk to coconut cream, which needed to be heated to completely dissolve the coconut fat globules. We began with this recipe and made a couple of alterations, decreasing the sugar from ¾ cup to ⅔ cup. With the addition of corn syrup, we found ¾ cup of sugar made the ice cream too sweet. We also eliminated the chocolate, since we wanted to better judge how the coconut milk and cream tasted as stand-alone ice cream.
Peach sorbet from the Musso – Mini 4080 Lussino.
The sorbets did not require cooking. However, we simmered the simple syrup we used in the sorbet to completely dissolve the sugar.
Here's the simple recipe we used for the sorbet: heat ½ cup sugar with one cup water until the sugar is dissolved. Add the simple syrup and ¼ cup light corn syrup to 12 ounces frozen fruit in a blender and puree. We experimented with frozen blueberries, raspberries, peaches, cherries, mango and lemon juice.
We prepared the same amount of ice cream base for each of the machines to produce one quart of ice cream. Since ice cream expands when the air is whipped in, the mixture needs to be less than the machine's capacity.
The mixtures were all chilled for at least 12 hours to allow the flavors to fully mature. The chilled base was then poured into each machine. The sorbet was already chilled from the frozen fruit, so we simply poured the mixture into the machine without refrigerating it overnight.
Four of the machines we tested were compressor models, meaning that they have an internal cooling unit, which eliminates pre-freezing the machine's inner canister. The compressor models also allow you to churn several quarts of ice cream in a couple of hours.
The compressor models were designed for ease of use and although they are all quite heavy and bulky, once we wiped the bowls, paddles (also known as "dashers") and bowl covers clean, we simply had to pour the mixture in and push a button.
We also tested a freezer bowl model, Cuisinart – ICE-60W Cool Creations and although it wasn't as convenient for making more than one-and-one-half quarts of ice cream per day, the machine was very easy to use once the bowl had been frozen the night before.
Vintage ice cream makers required manually churning the internal canister that's been packed in ice and rock salt (which lowers the temperature of the ice). There are a couple of automatic models on the market that have a nostalgic appeal. We tested the Hamilton Beach – 68330N, a popular, inexpensive ice-and-salt model, that we found to be charming but messy and inconvenient.
The compressor models had higher wattage (100 – 180 watts), which gave them the edge over the freezer-bowl model and the ice-and-salt model in churning the ice cream faster. Generally, the compressor models took about 30 minutes to make soft-serve ice cream you could serve immediately or freeze to firm up.
The compressor models were less consistent, however, when it came to churning sorbets and the non-dairy coconut ice cream that were firm enough to hold a scoop. For example, the high-end Musso – Mini 4080 Lussino churned out soft-serve ice cream in 30 minutes, but the sorbet and non-dairy coconut didn't firm up for 50 minutes.
Efficient liquid-gel freezer bowl freezes ice cream in 20 minutes.
The ICE-60W surprised us. The same amount of mixture (to produce 1.5 quarts) we used for the compressor models began freezing almost immediately before even turning the machine on. The ICE-60 differs from the compressor models in that the freezer bowl revolves while the dasher remains stationary. The vanilla and chocolate ice creams and the sorbet were at a scoopable consistency in 20 minutes, while the non-dairy coconut was firm in 15 minutes.
The biggest challenge for an ice cream maker is to recreate the smooth texture and the buttery stick-to-the-roof-of-your-mouth consistency of the ice cream you get at a professional ice cream parlor. Except for the Whynter, all of the machines we tested produced a soft-serve ice cream that needed to be frozen for at least two hours before serving.
You might actually prefer soft-serve to a more firm ice cream, but most of the manufacturers and professionals recommend that the churned ice cream should be frozen to give the ice cream a chance to "ripen", which is really just giving the ice crystals time to bind with the butterfat and give the ice cream density.
Freezing also changes the consistency and flavor of the ice cream. The Breville – BCI600XL Smart Scoop has automatic, pre-programmed settings and a manual option, which allows you to set a specific time for churning. The only choice you can make with the automatic, pre-programmed settings is how hard you want your ice cream to be. We experimented with different hardness levels and found little noticeable difference between them.
The Breville's automatic setting bulked up the frozen desserts to an almost fluffy consistency, which, when frozen, left the ice cream — particularly the vanilla — practically flavorless. The Breville's sorbet, however, was delicious and could be served immediately. Plus, it retained its bright fresh-fruit flavor.
We had less successful results with the Hamilton Beach. The unit's motor simply didn't have the power to whip enough air into the ice creams and sorbet. The taste of butterfat overwhelmed the vanilla and the chocolate and coconut ice creams and lemon sorbet were grainy and unappetizing.
We conducted our testing over a two-week period and discovered that without the commercially added stabilizers, none of the ice creams held up longer than five days. We carefully wrapped the desserts in plastic wrap and stored them in airtight containers.
Despite these efforts, the ice creams and sorbets we made at the beginning of the test period had radically deteriorated in texture and flavor. Thus, we recommend consuming homemade ice cream within two or three days.
A common criticism by Amazon reviewers of ice cream machines is that they're exceedingly noisy. Overall we did not find that to be the case. Of all the machines, the Breville was considerably less noisy. It simply emitted a low hum as it churned and was barely noticeable in the background.
The Breville compression style machine churns with a barely perceptible hum and looks great while doing it.
The Musso, Whynter and Cuisinart – ICE-100 made some noise as the dasher scraped the internal canisters, but they weren't annoying. The Cuisinart – ICE-60W clunked a bit as the freezer bowl spun and the Hamilton Beach made a loud grinding sound as if its motor would overheat and shut down.
One of the factors that you should consider when purchasing an ice cream maker is the convenience of using and cleaning it on a regular basis.
The compressor models we tested were stainless steel and the only parts that can be washed (not in the dishwasher) are their removable metal canisters and plastic dashers. The Whynter, ICE-100 and the Breville were especially easy to clean and ready to use again in minutes. The Breville even comes with its own small brush to clean the hard-to-reach canister cylinder. The ICE-60's freezer bowl, once defrosted, was also easy to clean.
The Musso gave us a couple of problems. The only removable part is the metal dasher and it freezes tight during the churning, which made it difficult to remove until we defrosted it with hot water. The Musso's instruction manual advises pouring hot water into the bowl, waiting 10 minutes and wiping it out with a sponge, then repeating until clean. We followed the instructions and needed to do the process several times before all soapy residue was removed.
The Hamilton Beach's canister and dasher were easy to detach and wash, but it was tricky to empty out the ice and salty water from the unit's bucket without spilling it everywhere.
The compressor models were certainly more convenient and easy to operate than the freezer bowl and automatic ice-and-salt models. Overall the compressor models performed reasonably as well as advertised.
However, we found that the Whynter – ICM-200LS stood out as the best compressor model that churned out extremely smooth, creamy and dense ice cream you'd expect from a high-end, artisan ice cream parlor. Whynter is known for refrigeration and air conditioning and their expertise was clearly applied when they designed an ice cream machine.
This compressor model consistently produced smooth and creamy ice cream and sorbet. Its powerful motor churns out desserts in less than 30 minutes.
The Whynter is incredibly user friendly: You simply pour the ice cream mixture into the canister, snap on the lid and push the "power" button. An LCD screen lights up with the options for Ice Cream, Cooling and Mixing Only (for add-ins once the ice cream has partially solidified). The digital countdown begins at 60 minutes and you can add or subtract from that default time.
The Whynter's powerful internal motor (180 watts) churned 1.5 quarts (its total capacity is 2.1 quarts) of vanilla custard ice cream to completion in only 25 minutes. It was the only ice cream from all of our test subjects that didn't need to be frozen before serving. It scooped up hard and dense and was perfectly smooth and creamy. An efficient plastic ice-cream scoop is included.
The egg-less chocolate ice cream wasn't as dense, but it was just as rich-tasting as the vanilla and intensely chocolate-y. The sorbet and non-dairy coconut took slightly longer to churn (28 minutes) and they were also flavorful and smooth.
The Whynter's extended cooling function kicks in automatically when the timer hits zero and the unit keeps the ice cream chilled for 30 minutes.
The removable canister and dasher were easy to wash and the machine's stainless steel wipes down beautifully. At over 25 pounds, the Whynter is one of the heaviest of our test subjects, so it's definitely a countertop appliance.
The Whynter costs about the same as the other compressor models we tested, so it's not inexpensive. However, because of the excellent quality of the ice cream it makes, we believe it's a worthwhile investment.
The Whynter churns out ice cream and other frozen desserts that taste exactly like what you would get from a professional ice cream parlor.
It's the only machine we tested that makes hard and soft-serve ice cream.
The Whynter has an add-in spout and programmed menu choice for pausing the churning for add-ins.
Its 2.1-quart capacity allows you to make a lot of ice cream in a short period of time.
The machine's automatic functions are very user-friendly and make ice-cream-making easy and fun.
For our runner-up, we chose another compressor model, the Cuisinart – ICE-100, which consistently churned out very good ice cream and sorbet in about 30 minutes. It runs about $50 less than the Wynter and although it's more expensive than the freezer-bowl and ice-and-salt models, we feel the price is worth it for the ICE-100's quality and convenience.
User-friendly and easy to clean, the ICE-100 makes terrific soft serve as well as sorbet.
We opted for the Whynter as our first choice and the Cuisinart – ICE-100 as our runner-up, because all of the ice cream the machine made was soft-serve and needed to be frozen before serving. After four hours of freezing time, the ICE-100's ice cream and sorbet had the taste and texture of high-end store-bought frozen desserts.
The ICE-100 is easy to use and after a quick wipe-down of the removable bucket and dasher, you can start making ice cream (as long as you have the mixture ready) with the unit straight out of the box. The ICE-100 has only three functions on its touchpad control: on/off, start/stop and a programmable LCD timer. A second dasher for making gelato is included, but we really didn't notice much difference in the churning.
Once the ice cream is done, the machine goes into an automatic cooling mode for 10 minutes. Unless you enjoy a soft-serve consistency, we recommend freezing the ICE-100's ice cream for two hours to let it firm up before serving.
The ICE-100 is about the same size as the Whynter, yet it makes somewhat less ice cream (1.5 quarts) and it doesn't have a spout for add-ins. The machine's stainless steel is easy to clean and the unit would make an attractive addition to your kitchen countertop.
While we disagree with Cuisinart's claim that the ICE-100 is a commercial-quality ice cream maker, it's certainly a reliable option for the ice-cream aficionado.
The ICE-100 makes very good soft-serve ice cream and gelato with the taste and texture of high-end store-bought ice cream.
Easy-to-use touchpad controls allow you to pause churning for add-ins.
Its powerful 150-watt motor efficiently churns 1.5 quarts in 30 minutes or less.
The ICE-100 has an attractive design and is easy to clean.
With a price tag of $700, the Musso – 4080 is certainly the Tesla of the ice cream machines we tested. It's a solidly constructed unit that could easily be used in a restaurant. The Musso's motor doesn't have the wattage of the other compressor models we tested, but it's so efficiently built that it has enough power to whip ice cream into a frothy and airy confection.
Gorgeously designed, the Musso makes restaurant-quality frozen desserts.
The Musso is manufactured in Italy and entirely made of stainless steel, so weighing in at 38 pounds, it's approximately the size of a small microwave and is clearly intended to have a permanent place in your kitchen. Design-wise, it's gorgeous, all ovals and sleek curves and when cleaned-up, it gleams. If you ever needed an ice-breaker at a party of strangers, the Musso would be it.
The stainless dasher screws into place and you pour in the ice cream mixture, then set the built-in manual timer (it resembles a vintage kitchen timer) to 40 minutes. The manual suggests 30 minutes, but we found that to be insufficient time. The Musso has two switches: Churn and Chill and the unit won't start until the timer is set.
The vanilla custard ice cream was done in 25 minutes and, of all the ice cream we tasted during our testing, it was the best: super smooth, velvety and flavorful. The eggless chocolate ice cream took five minutes less and it had the same rich consistency as the vanilla. The sorbet and non-dairy coconut seemed less smooth and flavorful, but once frozen, the magic chemistry happened and both were luscious.
It should be noted, however, that the ice cream the Musso produced was all soft-serve, which should either be eaten immediately or frozen to firm up.
For all of the beauty of the Musso, we did have a couple of quibbles. The dasher isn't able to reach the base of the bowl, so we needed to scrape up the quarter-inch thick frozen layer so it could be churned and incorporated into the ice cream.
Second, as noted above, washing the inner bowl and rinsing the soapy water is cumbersome because of the weight of the machine. Consequently, we had to wipe out the bowl several times before we felt confident that all residue was removed.
If you want to make ice cream of professional quality at home and you can afford it, then the Musso is the machine to buy.
Beautifully designed, solidly built and easy to use, the Musso makes professional-quality ice cream at home.
Its efficient motor and dasher churn out exceedingly smooth, creamy and airy soft-serve ice cream and gelato.
The Musso is an investment, but if you're serious about ice cream, it's worth it.
The highly rated Breville – Smart Scoop comes with lots of bells and whistles and although the ice cream we made in it was acceptable, we didn't feel the machine merited its considerable price tag.
The Breville is also a compressor unit that chills the machine to -22°F in approximately 10 minutes. It has an impressive LCD panel and various buttons for programming automatic settings for ice cream, gelato, sorbet and frozen yogurt, as well as a knob for adjusting the dessert's hardness. We found the machine chiming when it's time for add-ins and when the ice cream is ready to be a useful and accurate feature.
The Breville has a removable bucket and dasher and includes an efficient ice cream scraper and a small brush for cleaning. The machine has a powerful motor of 200 watts, but it emitted a harsh metallic odor throughout our testing period that never dissipated.
The Cuisinart – ICE-60W is a freezer-bowl model, so it does require some planning ahead of time because you'll need to freeze the bowl for at least 12 hours before using it. Since we needed to chill the ice cream mixture for the same amount of time, it really wasn't an issue for us. Many Amazon reviewers simply store the bowl in their freezers.
The ICE-60W differs most noticeably from the compressor models in that the bucket — not the dasher — revolves. Since the dasher doesn't move, the ice cream gets stuck in the upper third of the bowl, forming around one of the blades. During the churning, we had to continually scrape the ice cream off the dasher so it could be incorporated into the mixture.
However, despite this bit of maintenance, as we noted earlier, the freezer bowl is very efficient in quickly freezing the ice cream mixture, which began to freeze upon contact with the bowl. All of the ice cream and sorbet made in the ICE-60W were smooth with a soft-serve consistency.
A freezer-bowl model isn't as convenient as a compressor model, but it's certainly more affordable. The ICE-60W runs about $100, so it's a viable option for a less expensive ice cream maker.
At around $30, the Hamilton Beach – 68330N 4-quart ice cream maker is an Amazon top seller. Reviewers love the nostalgic fun of making ice cream with ice and rock salt and it can make twice as much for larger groups.
However, despite Hamilton Beach's claim that the model is not labor-intensive, we found it to be just the opposite. It's a cheaply made product consisting of a plastic bucket, a 4-quart metal cylinder that easily dents, a plastic dasher and a small motor in a plastic casing that snaps on top.
Although it's motorized, the Hamilton Beach requires 10 pounds of ice and a couple of cups of rock salt, which are layered inside the bucket around the sides of the cylinder. The noisy motor churns the dasher slowly and simply doesn't have the power to whip enough air into the ice cream.
During the machine's 50 minutes of churning, we needed to keep an eye on the ice and salt level, adding both half-way through the process. But before doing so, we had to remove the motor and canister, drain out the melted water, re-insert the canister and lock the motor back into place (no small feat).
The Hamilton Beach was definitely not a "set-it-and-forget-it" type of appliance. Whereas the other machines we tested were fun to use, the Hamilton Beach turned ice-cream making into a chore.
If you love ice cream like we do, then an ice cream machine isn't a luxury item but a "must-have" appliance that you'll want to use every day. The compressor model ice cream maker takes all the fuss and messes out of ice cream making of yore. The less-expensive machines might save you money at first, but we believe they won't hold up as long as the compressor models nor will they make ice cream you'll really enjoy.
For under $300, the Whynter – ICM-200LS is our top pick. It's easy to use, easy to clean and makes the same dense, rich and creamy ice cream and sorbet that you'd find at an ice cream parlor.
For a slightly less expensive option, we also recommend the Cuisinart – ICE-100, another compressor model, that's very user-friendly and makes a satisfying high-end supermarket ice cream.
And if money is no object, go for the Musso – 4080 Musso Lussino, an impeccably and beautifully designed machine that churns out restaurant-quality frozen desserts in 30 minutes.
Well-designed, user friendly and easy to clean, this self-refrigerating ice cream maker can continuously churn out several quarts of high-quality ice creams and sorbets in a couple of hours.
Gene Gerrard was recently voted as one of the top five personal chefs in Los Angeles. He created About.com's Meat and Wild Game Cooking website and published hundreds of recipes, interviews, cookbook reviews and blog posts about food trends. Gene is also a professional magician, and when he's not writing for Your Best Digs, he's performing at the World Famous Magic Castle in Hollywood.


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"Marriage is like a violin. After the music is over, you still have the strings. "
"Marriage is the only war in which you sleep with the enemy. "
"It is always incomprehensible to a man that a woman should ever refuse an offer of marriage. "
"Wives are young men's mistresses, companions for middle age, and old men's nurses. "
"Marriage is low down, but you spend the rest of your life paying for it. "
"Marriage is not a ritual or an end. It is a long, intricate, intimate dance together and nothing matters more than your own sense of balance and your choice of partner. "
"I married the first man I ever kissed. When I tell this to my children they just about throw up. "
"In matrimony, to hesitate is sometimes to be saved. "
"People marry through a variety of other reasons, and with varying results; but to marry for love is to invite inevitable tragedy. "
"When you make the sacrifice in marriage, you're sacrificing not to each other but to unity in a relationship. "
"When people get married because they think it's a long-time love affair, they'll be divorced very soon, because all love affairs end in disappointment. But marriage is a recognition of a spiritual identity. "
"If variety is the spice of life, marriage is the big can of leftover Spam. "
"If you are afraid of loneliness, don't marry. "
"Marriage is an adventure, like going to war. "
"The most happy marriage I can imagine to myself would be the union of a deaf man to a blind woman. "
"Marriage is like a bank account. You put it in, you take it out, you lose interest. "
"I've sometimes thought of marrying, and then I've thought again. "
"Marriage is a matter of give and take, but so far I haven't been able to find anybody who'll take what I have to give. "
"I'd marry again if I found a man who had 15 million and would sign over half of it to me before the marriage and guarantee he'd be dead within a year. "
"Marriage is a lottery in which men stake their liberty and women their happiness. "


Friday: Launch party for Widow Jane Whiskey, a single barrel bourbon. Cocktails, BBQ, Live Bluegrass music, whiskey distillation and white lightning from the still. At Cacao Prieto Distillery & Chocolate Factory, Red Hook. 7pm-10pm.
Friday: Celebrate Cider Week NY with Cheese and Cider at BKLYN Larder. Demo by Eve's Cidery plus cheese and cider pairings. Park Slope. 5pm-8pm.
• Saturday: Flatbush Food Coop, Cortelyou Road, Flatbush. 10am-4pm.
• Sunday: PS29 at Baltic Street, Cobble Hill. 10am-4pm.
Saturday & Sunday: Last weekend for Brooklyn Waterfront Artists Coalition (BWAC) Affordable Art Auction. Red Hook. Silent auction until 4pm each day. Winners can take art home by 6pm.
♥ Brownstoners of Bedford-Stuyvesant, Inc. 34th annual House Tour. Self-guided tour from 11am-4pm.
• Bed-Stuy Bazaar featuring merchandise from Fulton Arts Fair members. 10:30am-3:30pm.
Saturday: Prospect Park Food Truck Rally. To date, 16 trucks including: Bongo Brothers, Cupcake Crew, Eddies Pizza, Green Pirate, Kimchi Taco Truck, Mexicue, Milk Truck, Nuchas, Phil's Steaks, Red Hook Lobster, Rickshaw Truck, Schnitzel & Things, Souvlaki GR , Taïm Mobile, Wafels & Dinges. Sponsored by Prospect Park Alliance and the NYC Food Truck Association. Grand Army Plaza. 11am-5pm.
Saturday: 2nd annual Tastes of Brooklyn. Top Brooklyn chefs partner with farmers and seeds in the middle of the Greenmarket at Borough Hall. 11:30am-3pm.
Sunday: 3rd annual Havemeyer Sugar Sweets Festival. All-donation bake sale and baking competition to raise funds for The City Reliquary museum and civic organization. Baking Smackdown schedule: The most decadent vegan, 11am. Best fall-flavored treat, 12pm. Best sweet slice, 1pm. Best booze-infused, 2pm. Best In Show, 3pm. Williamsburg, 10am-4pm.
Sunday: Pickling Canning Workshop, one of a series of classes in practicing the skills of sustainable living. Everyone who attends will get a jar of something to bring home. Brooklyn Society for Ethical Culture, Park Slope. 1pm-3pm.
Sunday: 3rd annual MAC-OFF, a no-holds-barred competition to find the best version of the All-American classic macaroni and cheese. With complementary Ommegang BPA. Huckleberrybar, Williamsburg. 5pm-8pm.
Sunday in Outer Brooklyn: Closing day for Changing Hands, Art Without Reservation 3. Contemporary Native North American Art from the Northeast and Southeast. Museum of Art and Design. "MAD" explores the blur zone between art, design, and craft today. MAD's history of honoring the relationship between materials and maker is evident in their architecturally-fascinating space at Columbus Circle. Manhattan. 11am-6pm.
Joy Makon curates Brooklyn Artisan's Craft & Design coverage and creates the weekend to-do lists.


Thinking of using up this second P2P that expires in about a month. Considering another one under $500 to go with the M&P 40 Pro... maybe RIA 1911 9mm or an EAA Witness 9mm.
I'm thinking a GE Mini gun. Liquid lead !!
S&W 929, S&W 625 mountain gun in 45 colt or Ruger Sass Vaquero set in 357.
Someone will opine that it's too loud and dangerous for the victim and perp.
so i got my permits in and no local shop has a glock 20 in stock. and to order it they want way over what i'm willing to pay for a glock so that has been put on hold. one shop does have a sig m11-a1. i held one 2 weeks ago when i was in florida and didn't really like it. i saw it here and decided to give it another shot and it actually felt pretty good. i think the grips were different on the one in the florida shop. so i think that's the route i'm going for my first permit. no decision yet on my second permit.
Im looking a gen 4. They use the same frame as the 21 which I've held and it just points so much better for me. And I want 15 round mags not 10. Everywhere I find wants $650-700 for what I want.
no, maybe ill check him after the M11-A1 purchase.
I've decided on a Ruger SR40C. Now to save the $475 to buy it.
Just bought a Browning Buckmark and ordered a M&P Shield 9mm to go with my G17 and G23! Gotta use those permits up!
How do you like the shield? Seems a better carry for me then my Glock 23. I spend a lot of time in PA and Texas. I think the single stack 9 will work better for me than the double stack .40. I have never had any printing issues with it, but want to give the shield a go.
I put 100 rounds thru the shield a few weeks ago. Nice gun but it beat the hell out of my thumb knuckle. I find it to be too thin for me to get a firm grip so it rocks with each shot and the top of the backstrap bangs into my knuckle. HG has them to rent if you want to try before you buy.
I have both. PPQ m1 is one of my favorite pistols ever! M&P is really nice too. Never gave me an issue.
But I guess it's a good combo then!


text:
Aktien»Nachrichten»SANOFI AKTIE»Sanofi: Positive results presented from two Phase 3 trials of Dupixent (dupilumab) in severe chronic rhinosinusitis with nasal polyps
SANOFI SA
WKN: 920657 ISIN: FR0000120578 Ticker-Symbol: SNW
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GlobeNewswire (Europe)
Sanofi: Positive results presented from two Phase 3 trials of Dupixent (dupilumab) in severe chronic rhinosinusitis with nasal polyps
Source: Sanofi (EURONEXT: SAN) (NASDAQ: SNY)
Positive results presented from two Phase 3 trials of Dupixent (dupilumab) in severe chronic rhinosinusitis with nasal polyps
Dupixent showed significant improvement on every primary and secondary endpoint in patients with severe chronic rhinosinusitis with nasal polyps who had failed previous treatment with surgery and/or systemic corticosteroids
Dupixent also showed significant improvement of co-morbid asthma
PARIS and TARRYTOWN, NY - February 25, 2019 - Detailed results were presented from two Phase 3 trials in patients with recurring severe chronic rhinosinusitis with nasal polyps (CRSwNP) despite previous treatment with surgery and/or systemic corticosteroids. These trials, known as SINUS-24 and SINUS-52, demonstrated that Dupixent (dupilumab), when added to the standard of care corticosteroid nasal spray, improved nasal polyp size, nasal congestion severity, chronic sinus disease, sense of smell and co-morbid asthma outcomes. In these severe patients, Dupixent reduced the need for systemic corticosteroid use and the need for nasal/sinus surgery. These data were presented in two late-breaking sessions at the 2019 Annual Meeting of the American Academy of Allergy, Asthma & Immunology (AAAAI) in San Francisco.
"Dupixent is the first biologic therapy to demonstrate the potential to produce disease-modifying effects in severe CRSwNP, significantly improving all disease measures in the study, including sense of smell, one of the most troublesome and challenging-to-treat symptoms for patients," said Claus Bachert, M.D., Professor and Head of Clinics of the Department of Otorhinolaryngology at Ghent University and principal investigator of the trials. "Patients with co-morbid CRSwNP and asthma are often more difficult to treat so it is encouraging that Dupixent, which targets key drivers of Type 2 inflammation, may address both conditions in these patients."
Dupixent is a human monoclonal antibody specifically designed to inhibit signaling of interleukin-4 and interleukin-13 (IL-4 and IL-13). The findings from these studies, as well as from prior studies in atopic dermatitis and asthma, demonstrate that these are two key proteins that play a central role in Type 2 inflammation, which seem to underlie CRSwNP as well as several allergic diseases.
CRSwNP is a chronic disease of the upper airway predominantly driven by Type 2 inflammation and characterized by polyps that obstruct the sinuses and nasal passages. Patients may experience severe nasal obstruction with breathing difficulties, nasal discharge, reduced or loss of sense of smell and taste and facial pain or pressure. Persistent symptoms of CRSwNP have a substantial adverse impact on patients' health-related quality of life, which can be measured by a composite endpoint that includes reduced productivity and activities of daily living, inability to enjoy food, lack of sleep and fatigue.
Current treatment options are intranasal corticosteroids, systemic corticosteroids and surgery, all with suboptimal efficacy and/or high recurrence rates after treatment. Mometasone furoate nasal spray (MFNS) is a standard-of-care intranasal corticosteroid, and the Phase 3 SINUS-24 and SINUS-52 trials evaluated 300 mg Dupixent added to MFNS ("Dupixent group") compared to placebo injection plus MFNS ("placebo group").
The topline results for both trials were announced (http://hugin.info/152918/R/2220666/868954.pdf) in October 2018. These trials met their co-primary endpoints of change from baseline in nasal congestion/obstruction severity and change from baseline in nasal polyps score, measured at 24 weeks. Patients treated with Dupixent experienced a:
57% and 51% improvement in their nasal congestion/obstruction severity compared to a 19% and 15% improvement with placebo in SINUS-24 and SINUS-52, respectively (absolute change from baseline of -1.34 and -1.25 for Dupixent compared to -0.45 and -0.38 for placebo; p<0.0001 for both)
33% and 27% reduction in their nasal polyps score compared to a 7% and 4% increase for placebo in SINUS-24 and SINUS-52, respectively (absolute change from baseline of -1.89 and -1.71 for Dupixent compared to 0.17 and 0.10 for placebo; p<0.0001 for both)
New data presented at AAAAI
Dupixent significantly reduced chronic sinus disease in both trials. Dupixent treatment effects began as early as four weeks with progressive improvement up to 24 weeks in SINUS-24, a 24-week trial, and up to 52 weeks in SINUS-52. Both trials evaluated Dupixent treatment every two weeks for up to 24 weeks, and after week 24 through 52 weeks, SINUS-52 included a group of patients treated every four weeks in addition to a group treated every two weeks.
Patients in the Dupixent every two weeks group experienced a:
42% and 27% improvement in sinus opacification vs. 4% and 0% with placebo at 24 weeks in SINUS-24 and SINUS-52, respectively (absolute change from baseline of -8.18 and -5.21 for Dupixent vs. -0.74 and -0.09 for placebo; p<0.0001 for both). For patients in SINUS-52, a 37% improvement in sinus opacification was achieved with Dupixent treatment vs. 2% with placebo at 52 weeks (absolute change from baseline of -6.83 for Dupixent vs. 0.11 for placebo; nominal p<0.0001)
146% and 108% improvement in ability to identify different smells vs. 19% and 7% with placebo at 24 weeks in SINUS-24 and SINUS-52, respectively (absolute change from baseline of 11.26 and 9.71 for Dupixent vs. 0.7 and -0.81 for placebo; p<0.0001 for both). In both trials, Dupixent-treated patients reported an improvement in sense of smell as early as four weeks based on a separate daily assessment
60% and 51% improvement in health-related quality of life vs. 18% and 18% with placebo at 24 weeks in SINUS-24 and SINUS-52, respectively (absolute change from baseline of -30.43 and -27.77 for Dupixent vs. -9.31 and -10.4 for placebo; p<0.0001 for both). At 52 weeks, there was a 58% improvement in health-related quality of life with Dupixent vs. 14% with placebo (absolute change from baseline of -29.84 for Dupixent vs. -8.88; p<0.0001)
0.21L improvement in lung function vs. placebo at 24 weeks in SINUS-24 in the subset of patients with asthma at baseline (absolute change from baseline of 0.15L for Dupixent vs. -0.06L for placebo; nominal p=0.0004) and 0.21L improvement in lung function vs. placebo at 24 weeks in SINUS-52 (absolute change from baseline of 0.17L for Dupixent vs. -0.015L for placebo; nominal p<0.0001). In the trials, approximately 60% of patients had co-morbid asthma, most of them receiving asthma controller medication
73% reduction in rescue treatment with systemic corticosteroids or nasal polyp surgery compared with placebo at 24 weeks in SINUS-24 and 76% reduction in rescue treatment compared with placebo at 52 weeks in SINUS-52 (Kaplan-Meier estimates at 24 weeks were 7% for Dupixent vs. 23% for placebo in SINUS-24, HR 0.27 [95% CI: 0.13 to 0.55], nominal p=0.0003; and Kaplan-Meier estimates at 52 weeks were 13% for Dupixent vs. 44% for placebo in SINUS-52, HR 0.24 [0.16 to 0.36]; nominal p<0.0001)
Overall, rates of adverse events were generally similar between the Dupixent-treated group and placebo. Treatment-emergent adverse events occurred less frequently in the Dupixent group compared to placebo (65% vs. 71% in SINUS-24; 83% vs. 91% in SINUS-52). Adverse events that were observed more frequently in the Dupixent group compared with placebo included epistaxis (nosebleeds) in SINUS-24 (8% vs. 3%) and bronchitis (6% vs. 5%), cough (6% vs. 5%) and injection site reactions (3% vs. 2%) in SINUS-52. The rate of serious adverse events was 4% with Dupixent vs. 14% with placebo in SINUS-24, and 5% with Dupixent vs. 10% with placebo in SINUS-52. Adverse events leading to discontinuation occurred in 4% with Dupixent vs. 2% with placebo in SINUS-24 and 4% with Dupixent vs. 11% with placebo in SINUS-52.
Other Dupixent presentations at AAAAI included analyses on allergic rhinitis, CRSwNP and other sino-nasal outcomes in patients with co-morbid asthma or atopic dermatitis.
In the U.S., Dupixent is approved for treatment of adult patients with moderate-to-severe atopic dermatitis that is not well controlled by topical prescription therapies, or who cannot use topical therapies; Dupixent is also approved in the U.S for use with other asthma medicines for maintenance treatment of moderate-to-severe asthma in people aged 12 years and older with an eosinophilic phenotype or with oral corticosteroid dependent asthma. Other potential uses for Dupixent are investigational and the safety and efficacy have not been evaluated by the U.S. Food and Drug Administration, the European Medicines Agency or any other regulatory authority. Dupilumab is being developed jointly by Sanofi and Regeneron as part of a global collaboration agreement.
About the SINUS-24 and SINUS-52 trials
SINUS-24 (n=276) and SINUS-52 (n=448) were randomized double-blind, placebo-controlled pivotal Phase 3 trials in patients with severe CRSwNP. SINUS-24 included two treatment groups added to nasal spray: 300 mg Dupixent every two weeks for 24 weeks or placebo every two weeks for 24 weeks. SINUS-52 included three treatment groups added to nasal spray: 300 mg Dupixent every two weeks for 52 weeks, 300 mg Dupixent every two weeks for 24 weeks and then every four weeks until 52 weeks, or placebo every two weeks for 52 weeks. The co-primary and secondary endpoints of the trials included change from baseline in: nasal congestion/obstruction severity, a 0-3 scale, at 24 weeks (co-primary); nasal polyps score (a measure of polyp size), as assessed by nasal endoscopy, a 0-8 scale, at 24 weeks (co-primary); Lund-Mackay score, a 0-24 scale, as assessed by computed tomography (CT) scans at 24 weeks; University of Pennsylvania Smell Identification Test (UPSIT), 0-40 scale, at 24 weeks; severity of decreased or loss of smell by patient daily assessment on a 0-3 scale at 24 weeks; 22-item Sino-Nasal Outcome Test (SNOT-22), a 0-110 scale at 24 weeks; and the previous endpoints up to 52 weeks in SINUS-52.
Other pre-specified endpoints included the: change from baseline to 24 weeks in forced expiratory volume over one second (FEV1) in patients with co-morbid asthma; and proportion of patients during trial treatment who received rescue treatment with systemic corticosteroids and/or nasal polyp surgery.
The trials enrolled patients who were 18 years or older with bilateral nasal polyps who, despite treatment with systemic corticosteroids in the previous two years or history of surgery, continued to have ongoing moderate or severe symptoms of nasal congestion, blockage, loss of smell or nasal discharge. Consistent with the overlap seen among patients with Type 2 or allergic inflammatory diseases, more than three-quarters also suffered from other conditions, including asthma (approximately 59%), allergic rhinitis (approximately 58%) and NSAID-exacerbated respiratory disease (approximately 28%). Patients with co-morbid asthma and CRSwNP tend to have more severe disease.
Dupilumab development program
In addition to the approved indications in moderate-to-severe atopic dermatitis and moderate-to-severe asthma, Sanofi and Regeneron are also studying dupilumab in a broad range of clinical development programs for diseases driven by allergic and other Type 2 inflammation, including pediatric (6 to 11 years of age) atopic dermatitis (Phase 3), pediatric (6 months to 5 years of age) atopic dermatitis (Phase 2/3), adolescent (12 to 17 years of age) atopic dermatitis (Phase 3 completed), pediatric (6 to 11 years of age) asthma (Phase 3), eosinophilic esophagitis (Phase 2/3), and food and environment allergies (Phase 2). A future trial is planned for chronic obstructive pulmonary disease. Dupilumab is also being studied in combination with REGN3500, which targets IL-33. These potential uses are investigational and the safety and efficacy have not been evaluated by any regulatory authority.
For more information on dupilumab clinical trials please visit www.clinicaltrials.gov (http://www.clinicaltrials.gov).
About Regeneron
Regeneron (NASDAQ: REGN) is a leading biotechnology company that invents life-transforming medicines for people with serious diseases. Founded and led for 30 years by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to seven FDA-approved treatments and numerous product candidates in development, all of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye diseases, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, neuromuscular diseases, infectious diseases and rare diseases.
Regeneron is accelerating and improving the traditional drug development process through our proprietary VelociSuite technologies, such as VelocImmune which produces optimized fully-human antibodies, and ambitious research initiatives such as the Regeneron Genetics Center, which is conducting one of the largest genetics sequencing efforts in the world.
For additional information about the company, please visit www.regeneron.com (http://www.regeneron.com) or follow @Regeneron on Twitter.
About Sanofi
Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions.
With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe.
Sanofi, Empowering Life
Ashleigh Koss
Tel.: +1 (908) 981-8745
Ashleigh.Koss@sanofi.com
Regeneron Media Relations Contact
Sharon.Chen@regeneron.com
Investor Relations Contact
George Grofik
ir@sanofi.com (mailto:ir@sanofi.com)
Mark.Hudson@regeneron.com
Sanofi Forward-Looking Statements
This press release contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995, as amended. Forward-looking statements are statements that are not historical facts. These statements include projections and estimates regarding the marketing and other potential of the product, or regarding potential future revenues from the product. Forward-looking statements are generally identified by the words "expects", "anticipates", "believes", "intends", "estimates", "plans" and similar expressions. Although Sanofi's management believes that the expectations reflected in such forward-looking statements are reasonable, investors are cautioned that forward-looking information and statements are subject to various risks and uncertainties, many of which are difficult to predict and generally beyond the control of Sanofi, that could cause actual results and developments to differ materially from those expressed in, or implied or projected by, the forward-looking information and statements. These risks and uncertainties include among other things, unexpected regulatory actions or delays, or government regulation generally, that could affect the availability or commercial potential of the product, the absence of guarantee that the product will be commercially successful, the uncertainties inherent in research and development, including future clinical data and analysis of existing clinical data relating to the product, including post marketing, unexpected safety, quality or manufacturing issues, competition in general, risks associated with intellectual property and any related future litigation and the ultimate outcome of such litigation, and volatile economic conditions, as well as those risks discussed or identified in the public filings with the SEC and the AMF made by Sanofi, including those listed under "Risk Factors" and "Cautionary Statement Regarding Forward-Looking Statements" in Sanofi's annual report on Form 20-F for the year ended December 31, 2017. Other than as required by applicable law, Sanofi does not undertake any obligation to update or revise any forward-looking information or statements.
Regeneron Forward-Looking Statements and Use of Digital Media
This press release includes forward-looking statements that involve risks and uncertainties relating to future events and the future performance of Regeneron Pharmaceuticals, Inc. ("Regeneron" or the "Company"), and actual events or results may differ materially from these forward-looking statements. Words such as "anticipate," "expect," "intend," "plan," "believe," "seek," "estimate," variations of such words, and similar expressions are intended to identify such forward-looking statements, although not all forward-looking statements contain these identifying words. These statements concern, and these risks and uncertainties include, among others, the nature, timing, and possible success and therapeutic applications of Regeneron's products, product candidates, and research and clinical programs now underway or planned, including without limitation Dupixent (dupilumab) Injection; the likelihood, timing, and scope of possible regulatory approval and commercial launch of Regeneron's late-stage product candidates and new indications for marketed products, such as dupilumab for the treatment of chronic rhinosinusitis with nasal polyps, pediatric atopic dermatitis, pediatric asthma, eosinophilic esophagitis, grass allergy, food allergy (including peanut), chronic obstructive pulmonary disease, and other potential indications (as well as in combination with REGN3500); unforeseen safety issues resulting from the administration of products and product candidates (such as dupilumab) in patients, including serious complications or side effects in connection with the use of Regeneron's product candidates in clinical trials; ongoing regulatory obligations and oversight impacting Regeneron's marketed products (such as Dupixent), research and clinical programs, and business, including those relating to patient privacy; determinations by regulatory and administrative governmental authorities which may delay or restrict Regeneron's ability to continue to develop or commercialize Regeneron's products and product candidates, including without limitation dupilumab; the availability and extent of reimbursement of the Company's products (such as Dupixent) from third-party payers, including private payer healthcare and insurance programs, health maintenance organizations, pharmacy benefit management companies, and government programs such as Medicare and Medicaid; coverage and reimbursement determinations by such payers and new policies and procedures adopted by such payers; uncertainty of market acceptance and commercial success of Regeneron's products and product candidates (such as Dupixent) and the impact of studies (whether conducted by Regeneron or others and whether mandated or voluntary) on the commercial success of any such products and product candidates; competing drugs and product candidates that may be superior to Regeneron's products and product candidates; the extent to which the results from the research and development programs conducted by Regeneron or its collaborators may be replicated in other studies and lead to therapeutic applications; the ability of Regeneron to manufacture and manage supply chains for multiple products and product candidates; the ability of Regeneron's collaborators, suppliers, or other third parties to perform manufacturing, filling, finishing, packaging, labeling, distribution, and other steps related to Regeneron's products and product candidates; unanticipated expenses; the costs of developing, producing, and selling products; the ability of Regeneron to meet any of its financial projections or guidance and changes to the assumptions underlying those projections or guidance; the potential for any license or collaboration agreement, including Regeneron's agreements with Sanofi, Bayer, and Teva Pharmaceutical Industries Ltd. (or their respective affiliated companies, as applicable), to be cancelled or terminated without any further product success; and risks associated with intellectual property of other parties and pending or future litigation relating thereto, including without limitation the patent litigation proceedings relating to EYLEA (aflibercept) Injection, Dupixent, and Praluent (alirocumab) Injection, the ultimate outcome of any such litigation proceedings, and the impact any of the foregoing may have on Regeneron's business, prospects, operating results, and financial condition. A more complete description of these and other material risks can be found in Regeneron's filings with the U.S. Securities and Exchange Commission, including its Form 10-K for the year ended December 31, 2018. Any forward-looking statements are made based on management's current beliefs and judgment, and the reader is cautioned not to rely on any forward-looking statements made by Regeneron. Regeneron does not undertake any obligation to update publicly any forward-looking statement, including without limitation any financial projection or guidance, whether as a result of new information, future events, or otherwise.
Regeneron uses its media and investor relations website and social media outlets to publish important information about the Company, including information that may be deemed material to investors. Financial and other information about Regeneron is routinely posted and is accessible on Regeneron's media and investor relations website (http://newsroom.regeneron.com) and its Twitter feed (http://twitter.com/regeneron).
Press release (pdf) (http://hugin.info/152918/R/2236376/880714.pdf)
This announcement is distributed by West Corporation on behalf of West Corporation clients.
The issuer of this announcement warrants that they are solely responsible for the content, accuracy and originality of the information contained therein.
Source: Sanofi via Globenewswire
SANOFI-Aktie jetzt für 4€ handeln - auf Smartbroker.de
© 2019 GlobeNewswire (Europe)
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redpajama_set_name: RedPajamaCommonCrawl


Fashionista Sylvia Owori has launched her latest website sylviaowori.co.ug that will be able to handle online sales. Sylvia is one of the personalities in East Africa when it comes to fashion and has been in the industry for the last eleven years.
Sylvia in one of her earlier tweets before the launch wrote that: "You will now be able to buy our collections online and deliveries can be made within Uganda and Kenya."
The website was launched on Saturday 23.Feb.2013 at the Sylvia Owori shop located at Garden City complex on 3rd floor. This is the second website the fashionista is launching.
Today was the launch of the website and late night shopping sponsored by Redds. At the time of the launch, the site had collections ranging from ladies handbags, clothes and women shoes among others though it did not have a shopping cart.
The website is up though some fields are not yet operational like the create account, login and Contact us, hopefully these will be addressed in due course, short of that, it was a nice site.


text:
package org.pimslims.presentation;

import java.text.SimpleDateFormat;
import java.util.Calendar;
import java.util.Collection;
import java.util.HashSet;
import java.util.List;
import java.util.Set;
import java.util.SortedSet;
import java.util.TreeSet;

import org.pimslims.dao.ReadableVersion;
import org.pimslims.lab.Utils;
import org.pimslims.metamodel.ModelObject;
import org.pimslims.model.accessControl.User;
import org.pimslims.model.core.LabBookEntry;
import org.pimslims.model.experiment.Experiment;
import org.pimslims.model.target.ResearchObjective;
import org.pimslims.model.target.ResearchObjectiveElement;
import org.pimslims.model.target.Target;

/**
 * DayBean
 *
 */
public class DayBean {

    private String formattedDate;

    private String linkFormattedDate;

    private Collection<ModelObjectShortBean> experiments;

    private Collection<ModelObjectShortBean> otherObjects;

    private SortedSet<ModelObjectBeanTree> targets;

    /**
     * Constructor for DayBean
     */
    private DayBean() {
        super();
    }

    /**
     * @return Returns the experiments.
     */
    public Collection<ModelObjectShortBean> getExperiments() {
        return this.experiments;
    }

    /**
     * @return Returns the otherObjects.
     */
    public Collection<ModelObjectShortBean> getOtherObjects() {
        return this.otherObjects;
    }

    /**
     * @return Returns the targets.
     */
    public SortedSet<ModelObjectBeanTree> getTargets() {
        return this.targets;
    }

    /**
     * @param experiments The experiments to set.
     */
    private void setExperiments(final Collection<ModelObjectShortBean> experiments) {
        this.experiments = experiments;
    }

    /**
     * @param otherObjects The otherObjects to set. TODO ModelObjectShortBeans
     */
    private void setOtherObjects(final List<ModelObjectShortBean> others) {
        this.otherObjects = others;
    }

    /**
     * @return Returns the targets.
     *
     *         public SortedSet<ModelObjectBeanTree> getTargets() { return this.targets; }
     */

    /**
     * @param targets The targets to set.
     */
    public void setTargets(final SortedSet<ModelObjectBeanTree> targets) {
        this.targets = targets;
    }

    /**
     * @return Returns the formattedDate.
     */
    public String getFormattedDate() {
        return this.formattedDate;
    }

    /**
     * @return Returns the linkFormattedDate.
     */
    public String getLinkFormattedDate() {
        return this.linkFormattedDate;
    }

    /**
     * @param linkFormattedDate The linkFormattedDate to set.
     */
    private void setLinkFormattedDate(final String linkFormattedDate) {
        this.linkFormattedDate = linkFormattedDate;
    }

    /**
     * @param formattedDate The formattedDate to set. TODO no, get from Calendar
     */
    public void setFormattedDate(final String formattedDate) {
        this.formattedDate = formattedDate;
    }

    public static DayBean getDayBean(final Calendar day, final ReadableVersion version, final String userName) {

        final User user = version.findFirst(User.class, User.PROP_NAME, userName);
        final Calendar nextDay = (Calendar) day.clone();
        nextDay.add(Calendar.DATE, 1);

        final Collection<LabBookEntry> labBookEntries =
            LabBookEntryDAO.findLabBookEntries(day, nextDay, version, user);

        return DayBean.resort(labBookEntries, day);

    }

    public static DayBean resort(final Collection<LabBookEntry> labBookEntries, final Calendar day) {
        final DayBean dayBean = new DayBean();

        final SimpleDateFormat df = new SimpleDateFormat(Utils.day_date_month_format);
        dayBean.setFormattedDate(df.format(day.getTime()));

        final SimpleDateFormat ldf = new SimpleDateFormat(Utils.link_date_format);
        dayBean.setLinkFormattedDate(ldf.format(day.getTime()));

        final SortedSet<ModelObjectBeanTree> targets = new TreeSet<ModelObjectBeanTree>();
        final Set<ModelObject> experiments = new HashSet<ModelObject>();
        final Set<ModelObject> otherObjects = new HashSet<ModelObject>();

        final Calendar nextDay = (Calendar) day.clone();
        nextDay.add(Calendar.DATE, 1);

        for (final LabBookEntry labBookEntry : labBookEntries) {
            if ((labBookEntry.getLastEditedDate() != null && (!labBookEntry.getLastEditedDate().before(day)) && labBookEntry
                .getLastEditedDate().before(nextDay))
                || (labBookEntry.getCreationDate() != null && (!labBookEntry.getCreationDate().before(day)) && labBookEntry
                    .getCreationDate().before(nextDay))) {
                // experiments
                if (labBookEntry instanceof org.pimslims.model.experiment.Experiment) {
                    final Experiment experiment = (Experiment) labBookEntry;
                    if (null == experiment.getExperimentGroup()) {
                        experiments.add(labBookEntry);
                    }
                }
                if (labBookEntry instanceof org.pimslims.model.experiment.ExperimentGroup) {
                    experiments.add(labBookEntry);
                }
                // targets and constructs
                if (labBookEntry instanceof org.pimslims.model.target.Target) {
                    if (!targets.contains(labBookEntry)) {
                        targets.add(new ModelObjectBeanTree(labBookEntry));
                    }
                }
                if (labBookEntry instanceof org.pimslims.model.target.ResearchObjective) {
                    final ResearchObjective blueprint = (ResearchObjective) labBookEntry;
                    if (blueprint.getResearchObjectiveElements().size() > 0) {
                        final ResearchObjectiveElement component =
                            blueprint.getResearchObjectiveElements().iterator().next();

                        final Target target = component.getTarget();
                        if (null != target) {
                            if (!targets.contains(target)) {
                                targets.add(new ModelObjectBeanTree(target));
                            }

                            for (final ModelObjectBeanTree bean : targets) {
                                if (bean.equals(target)) {
                                    bean.add(new ModelObjectBeanTree(blueprint));
                                }
                            }
                        }
                    }
                }
                // other objects
                if ( // labBookEntry instanceof org.pimslims.model.people.Person                     ||
                labBookEntry instanceof org.pimslims.model.people.Organisation
                    || labBookEntry instanceof org.pimslims.model.sample.RefSample
                    || labBookEntry instanceof org.pimslims.model.sample.Sample
                    || labBookEntry instanceof org.pimslims.model.protocol.Protocol) {
                    otherObjects.add(labBookEntry);
                }
            }
        }

        dayBean.setExperiments(ModelObjectShortBean.getBeans(experiments));
        dayBean.setTargets(targets);
        dayBean.setOtherObjects(ModelObjectShortBean.getBeans(otherObjects));

        return dayBean;
    }

}

redpajama_set_name: RedPajamaGithub


text:
Tag Archives: Poet
Leighton Bromswold Huntingdonshire
St Mary's Church, Leighton Bromswold, Huntingdonshire.
St Mary's Church in Leighton Bromswold Huntingdonshire, in 1626 it was in a deplorable state of decay when the poet George Herbert was inducted as Prebend.
He made it his mission to raise the funds and restore the church along with the help of his friend Nicholas Ferrar and his brother John of Little Gidding.
THE CROSS.
By George Herbert
What is this strange and uncouth thing?
To make me sigh, and seek, and faint, and die,
Until I had some place, where I might sing,
And serve thee; and not only I,
But all my wealth, and family might combine
To set thy honour up, as our design.
And then when after much delay,
Much wrestling, many a combat, this dear end,
So much desir'd, is giv'n, to take away
My power to serve thee; to unbend
All my abilities, my designs confound,
And lay my threat'nings bleeding on the ground.
One ague dwelleth in my bones,
Another in my soul (the memory
What I would do for thee, if once my groans
Could be allow'd for harmony):
I am in all a weak disabled thing,
Save in the sight thereof, where strength doth sting.
Besides, things sort not to my will,
Ev'n when my will doth study thy renown:
Thou turnest th' edge of all things on me still,
Taking me up to throw me down:
So that, ev'n when my hopes seem to be sped,
I am to grief alive, to them as dead.
To have my aim, and yet to be
Farther from it than when I bent my bow;
To make my hopes my torture, and the fee
Of all my woes another woe,
Is in the midst of delicates to need,
And ev'n in Paradise to be a weed.
Ah my dear Father, ease my smart!
These contrarieties crush me: these cross actions
Do wind a rope about, and cut my heart:
And yet since these thy contradictions
Are properly a cross felt by thy Son,
With but four words, my words, Thy will be done.
We have visited Leighton Bromswold in Huntingdonshire on many occasions stopping to look around the outside of The Church of St Mary's as we have never found it open.
Well today was different, as we went to drive past on our way to who knows where, to our pleasant surprise there was a notice announcing that the church was open, hastily parking the car we were able to fulfil a long time ambition and were not in the least disappointed.
The Inside of St Mary's Church, Leighton Bromswold, Huntingdonshire.
With its Pulpit and Reading Desk of the same size
St Mary the Virgin Church, Leighton Bromswold, Huntingdonshire.
Its tower dominating the countryside.
St Mary's Church, Leighton Bromswold, Huntingdonshire
This entry was posted in Cambridgeshire, George Herbert and tagged Cambridgeshire, Church, George Herbert, Huntingdonshire, John Ferrar, Leighton Bromswold, Nicholas Ferrar, Poet, St Marys, The Cross by George Herbert on February 15, 2017 by James P Miller.
Keyston
The Church of St John the Baptist Keyston is a challenge,
Getting there without setting tyre rubber on the A14.
Taking a photograph that does the building justice.
Keyston lies on the very westerly edge of the county of Cambridgeshire or Huntingdonshire, if your preference is for the historic rather than the modern and are prepared to defy the 1974 Local Government edict.
It sits to the east of the town of Thrapston in Northamptonshire, which boasts connections with George Washington's family, the first president of the United States of America and west of Huntingdon the birth place of Oliver Cromwell. In the North lies the village of Titchmarsh with all its associations with the poet John Dryden and is with easy reach if you are prepared take your life in your hands and cross the A14 which carries its traffic incessantly between Felixstowe, the Midlands and beyond.
Our visit to Keyston in Huntingdonshire is purely of a metaphysical inspiration as John Donne, lawyer, renowned preacher, poet and soon to be become Dean of St Pauls Cathedral was awarded the living of Keyston in the early part of 1616. He held this post until 1621 when he resigned it shortly before he was appointed Dean of St Pauls.
The Church of St John the Baptist, Keyston, Huntingdonshire
"Thou hast set up many candlesticks, and kindled many lamps in me; but I have either blown them out, or carried them to guide me in forbidden ways."
This entry was posted in Cambridgeshire, John Donne and tagged 1974 Local Government Act, A14, Cambridgeshire, Dean of St Pauls Cathedral, George Washington, Huntingdon, Huntingdonshire, John Donne, John Dryden, Keyston, Lawyer, Metaphysical Poets, Northamptonshire, Oliver Cromwell, Poet, Preacher, President of the United States of America, The Church of St John the Baptist, Thrapston, Titchmarsh on January 19, 2015 by James P Miller.
Aldwincle Northamptonshire Revisited
In a time gone by there were two Aldwincle Parishes, Aldwincle St Peters and Aldwincle All Saints they were joined together in November 1879.
Aldwincle Village Sign Northamptonshire
To all appearances it is St Peters that is now the center of village life as All Saints sits a world apart opposte Dryden house on the way to Thorpe Waterville across Harper's Brook and over the Nene river by Brancey Bridge.
All Saints Church Aldwincle Northamptonshire
John Dryden poet, playwright and critic was born in the house that sits in the shadow of church on the 9 August 1631.
Dryden House Aldwincle Northamptonshire
Son of Erasmas Dryden and Mary Pickering of Titchmarsh he was Christened in the Church of All Saints where his grandfather Henry Pickering was Rector were there is a tablet commemorating the event.
Church Commemorative Tablet
All Saints Church is now in the care of The Church Conservation Trust as it is no longer needed for regular worship but remains as consecrated buildings and is of historical importance, it is a delight to walk round and has always been open when ever we have visited.
All Saints Church Striking Interior
All Saints Church Stained Glass Window
Samuel Johnson summed up the general attitude to John Dryden with his remark that
"the veneration with which his name is pronounced by every cultivator of English literature,
is paid to him as he refined the language, improved the sentiments,
and tuned the numbers of English poetry."
And T. S. Eliot wrote that he was
'the ancestor of nearly all that is best in the poetry of the eighteenth century',
and that 'we cannot fully enjoy or rightly estimate a hundred years of English poetry
unless we fully enjoy Dryden.'
This entry was posted in John Dryden, Northamptonshire and tagged 9 August 1631, Aldwincle, All Saints, All Saints Church, Brancey Bridge, Christened, Church, critic, Dr Samuel Johnson, Dryden House, Erasmas Dryden, Harper's Brook, Henry Pickering, John Dryden, Mary Pickering, Northamptonshire, playwright, Poet, Poet Birthplace, Rector, River Nene, Stained Glass Window, T. S. Eliot, The Church Conservation Trust, Thorpe Waterville, Titchmarsh, Village Sign on August 9, 2013 by James P Miller.
The Crest of A Scottish Clan, A Peel of Bells, Lord Peter Winsey and The Art of Cation Writting.
Walking in the Cambridgeshire fens along the Ouse Washes between The Bedford Rivers is always a comfort to a weary soul and evocative of The Nine Taylors by Dorothy L Sayers especially when the washes are in full flood.
With camera in hand it is always tempting to capture the wide open space, the large sky, reflections in the flood plain or Fortrey's pumping station standing on Engine Bank against a cloudy sky.
There are endless possibilities in the detail of the landscape like the bee seeking substance from the thistle on the bank of the hundred foot drain. The problem arises when trying to find a caption appropriate for the composition.
Now as mentioned this is the land where Lord Peter Wimsey applies his analytic mind to discovering the location of the Wilbraham emeralds and the murderer of the butler Deacon but try as I may I can find no correlation to the thistle and the bee but if we take a leaf out of Lord Peter's book and apply some meticulous reasoning, like the landscape itself there are endless possibilities.
Shakespeare's Midsommer Nights Dream could be applied where Bottom states
Mounsieur Cobweb, good mounsieur, get you your
weapons in your hand, and kill me a red-hipped
humble-bee on the top of a thistle; and, good
mounsieur, bring me the honey-bag. Do not fret
yourself too much in the action, mounsieur; and,
good mounsieur, have a care the honey-bag break not;
I would be loath to have you overflown with a
honey-bag, signior. Where's Mounsieur Mustardseed?
or we could turn to the poet Ted Hughes for The Thistle
Against the rubber tongues of cows and the hoeing hands of men
Thistles spike the summer air
And crackle open under a blue-black pressure.
Not to mention Sylvia Plath for the bee or perhaps Emily Dickinson
and her poem entitled There is a Flower that Bees Prefer
There is a flower that Bees prefer —
And Butterflies — desire —
To gain the Purple Democrat
The Humming Bird — aspire —
And Whatsoever Insect pass —
A Honey bear away
Proportioned to his several dearth
And her — capacity —
Her face be rounder than the Moon
And ruddier than the Gown
Or Orchis in the Pasture —
Or Rhododendron — worn —
We could even use a quote or two from A A Milne's Winnie-the-Pooh due to his love of honey and his friend Eeyore's passion for thistles.
If we were looking for a more modern example then A Single Thistle by Raymond A. Foss could be appropriate but as he reminds us, if we need reminding that the thistle is the flower of Scotland
therefore it has to be the motto and the crest of The Clan Fergusson as this uses both the bee and the thistle and also appeals to my Scottish roots.
Title: dulcius ex asperis
Caption: A Bee on a Thistle
The crest of The Clan Fergusson
Their Motto: dulcius ex asperis (sweeter after difficulties).
Found living on The Ouse Washes, The Fens, Mepal, Cambridgeshire
This entry was posted in Cambridgeshire, Ramblings and tagged A A Milne, Bee, Cambridgeshire, Clan Fergusson, Dorthey L Sayers, Eeyore, Emily Dickinson, Engine Bank, Fortrey's Pumping Station, Lord Peter Wimsey, Mepal, Midsommer Nights Dream, Ouse Washes, Poet, Raymond A. Foss, Scotland, Scottish Emblen, Shakespeare, Ted Hughes, The Bedford Rivers, The Fens, The Nine Taylors, Thistle, Wilbraham Emeralds, Winnie-the-Pooh on July 21, 2013 by James P Miller.
Edwin Muir. Swaffham Prior, Cambridgeshire.
Born in Orkney in 1887.
Socialist, Critic, Contributor to The New Age Magazine, Translator, one of Scotland's best poets and perhaps a counter balance to Hugh MacDiarmid vision of Scotland and poetic language?
Laid to rest in Swaffham Prior churchyard Cambridgeshire along with his beloved wife Willa Anderson who was an author in her own right.
In 1919 he married Willa Anderson and said not long after that "my marriage was the most fortunate event in my life". They collaborated on English translations of such writers as Franz Kafka, Gerhart Hauptmann, Sholem Asch, Heinrich Mann, and Hermann Broch.
We were a tribe, a family, a people.
Wallace and Bruce guard now a painted field,
And all may read the folio of our fable,
Peruse the sword, the sceptre and the shield.
A simple sky roofed in that rustic day,
The busy corn-fields and the haunted holms,
The green road winding up the ferny brae.
But Knox and Melville clapped their preaching palms
And bundled all the harvesters away,
Hoodicrow Peden in the blighted corn
Hacked with his rusty beak the starving haulms.
Out of that desolation we were born.
Edwin Muir From Scotland 1941.
This entry was posted in Cambridgeshire, Edwin Muir and tagged Cambridgeshire, churchyard, critic, Franz Kafka, Gerhart Hauptmann, Hugh MacDiarmid, Orkney, Poet, Scotland, Scotland 1941, Sholem Asch, Socialist, St Cyriac and St Julitta, St Mary, Swaffham Prior, The New Age Magazine, Village Sign, Willa Anderson on October 8, 2012 by James P Miller.
Aldwincle Northamptonshire
John Dryden poet, playwright, critic was born in Aldwincle Northamptonshire in 9 August 1631 and Christened in the Church of All Saints where his grandfather was Rector.
The house in which he was born still stand in the shadow of All Saints Church.
All Saints Church is now in the care of The Church Conservation Trust as it is no longer needed for regular worship but remains as consecrated buildings and is of historical importance.
What weight of ancient witness can prevail,
If private reason hold the public scale?
But gracious God, how well does thou provide
For erring judgements an unerring guide!
Thy throne is darkness in the abyss of light,
A blaze of glory that forbids the sight.
O teach me to believe thee thus concealed,
And search no further than thyself revealed;
But her alone for my director take,
Whom thou hast promised never to forsake!
John Dryden From Confessio Fidei
This entry was posted in Northamptonshire and tagged 1631, 9 August 1631, Aldwincle, All Saints, Christened, Confessio Fidei, critic, Dryden House, John Dryden, Northamptonshire, playwright, Poet, The Church Conservation Trust, Village Sign on May 11, 2012 by James P Miller.
In Memory of Violet May, Order and Method and a Lesser Known Poet.
I have a compulsion to rearrange our books, I would not go as far as to say it was a disorder but it is a desire to bring some sort of order to what has all the appearance of chaos.
The dilemma I have is do I catalogue them in alphabetical order, by author or should Dorothy L Sayers creation Lord Peter Wimsey sit dust jacket to dust jacket next to Agatha Christie's Poirot.
Now there is a thought I could follow the great Belgian detective's principles and arrange them in order of size.
If this all seems rather indecisive I am not completely without resolve in that I have separated the poets, not on the top shelve as some would wish, on the understanding that poetry is one of the highest forms of art but on a dedicated shelve next to the fire-place, ideal for the likes of Dante's Inferno.
There are always some surprises in familiar stanzas by Wordsworth, Keats or Clare and even more in less familiar as Auden, Spender or Smith.
As I placed each with the care owing on its rightful shelve position I came across a newspaper cutting from the early nineteen eighties nestled between Dryden and Eliot. It was written in nineteen seventy nine in memory of a lovely lady who was called to meet her maker in May of that year and was written by the author of these ramblings.
MAY TWENTY FITHH
I looked at you today,
And cursed the evil pen
That wrltes with twisted hand
The lines of pain upon your face.
Sleep on, druggrd sleep.
I know you think of those
Even through your pain,
That never had the time to share
From their seasonal warmth.
Sleep on.
But merciful is the Lord,
The flame you carried high,
Was from His lamp.
Sleep on today,
Tomorrow we will meet,
Sleep on today.
MAY THIRTIETH
J. P. Miller
This entry was posted in Ramblings and tagged Agatha Christie, Auden, Belgian Detective, Books, Dante, Dante's Inferno, Dorothy L Sayers, Dryden, Eliot, John Clare, Keats, Lord Peter Wimsey, memory, Order and Method, Poet, Poetry, Poirot, Smith, Spender, Violet May, Wordsworth on May 5, 2012 by James P Miller.


NOTE: We're looking for a knowledgeable Jason Mraz nerd! A review for Mr. A-Z hasn't been published — yet. We need someone who can write a full track-by-track review of this album (at least a couple paragraphs per song); if you know the music, you can submit a review. You'll be compensated when visitors make purchases through vendor links on their pages — for as long as your review remains on the site. Get more details in the FAQ.
NOTE: We're looking for a knowledgeable Jason Mraz nerd! A review for Tonight, Not Again: Jason Mraz Live At The Eagles Ballroom hasn't been published — yet. We need someone who can write a full track-by-track review of this album (at least a couple paragraphs per song); if you know the music, you can submit a review. You'll be compensated when visitors make purchases through vendor links on their pages — for as long as your review remains on the site. Get more details in the FAQ.
NOTE: We're looking for a knowledgeable Jason Mraz nerd! A review for Waiting For My Rocket To Come hasn't been published — yet. We need someone who can write a full track-by-track review of this album (at least a couple paragraphs per song); if you know the music, you can submit a review. You'll be compensated when visitors make purchases through vendor links on their pages — for as long as your review remains on the site. Get more details in the FAQ.


Irvine Subaru knows it's easy to find yourself swimming in a sea of options when you make the decision to purchase a crossover SUV. We know that all our customers throughout the Orange County area, especially in Lake Forest, Anaheim, Irvine and Tustin have busy lives full of important obligations for themselves and loved ones. For this reason we're confident that the 2017 Subaru Forester is the perfect choice of SUV to cater to your busy lifestyle while still offering the versatility you need for a weekend adventure anytime you see fit. Take a look below to see how this enviable model compares to its competitor, the Honda CR-V.
First things first... price. The Subaru Forester comes in at $23,470, under the Honda CR-V, which is priced at $24,645.
The Subaru Forester's base engine slightly outweighs the Honda CR-V at 2.5-liters as opposed to 2.4-liters.
All wheel drive comes standard on the Subaru Forester whereas it's only available on the Honda CR-V, which comes standard with front-wheel drive.
You'll appreciate the Subaru Forester's standard HD radio inside its cabin, which isn't available on the Honda CR-V.
An anti-theft system comes standard on the Subaru Forester while it's only available on other styles of the Honda CR-V.
The Subaru Forester boasts slightly more cargo capacity at 74.7 cubic feet in comparison to the Honda CR-V's 70.9 cubic feet.
Treat yourself and the ones you love to a daily driving experience you'll always look forward to with the Subaru Forester. Why not come take it for a test spin today? We're located in Lake Forest and we're looking forward to seeing you soon.


Description: This is a wire assembly terminated with the same 8-pin JST-SH connector which is on the Mega Pro Mini. Pick up a few of these to break out all of those pesky pins. Integrating these connectors into your projects makes it possible to quickly swap out a Mega Pro Mini between two or more different enclosures. One end is terminated with a JST-SH connector and the other end is tinned bare wire leads.
Note: The color of these wires may change from batch to batch so be sure to check your pinouts!


Everyone wants the best deal in regards to purchasing a car. Many people are unaware of what is required of them should they are going to get that job done. Some individuals even think they got the best deal when they actually are mistaken. Consider the next helpful advice when learning more about finding the best deals.
Prior to even stepping foot in a dealership, you need to find out what type of car you want. When you yourself have kids, maybe you need to be looking for a van or large SUV. If it's just you, maybe you want something more sportier. In any event, knowing what you want is likely to make the whole procedure for shopping for a car easier.
When buying a used car, a good way to inform if the car has been in an accident would be to look into the door frames. Usually each time a car is repainted, you'll notice over spray in this area. This is simply not proof a car was in an accident, nonetheless it enables you to know it absolutely was repainted.
You need to find out important info about the particular dealer before you give an offer. This helps you prepare yourself for the negotiation phase. Reading customer reviews also can give you a good picture of what maybe you are getting into.
It may possibly not be easy securing the most effective deal on a vehicle, nonetheless it doesn't need to be the absolute most difficult situation either. You only have to know what direction to go in order to counter from the salesmen's tactics. After you have this down, you're sure to complete better on the next purchase.


If state governments were to fully develop IT-driven productivity strategies, they could realize as much as $11 billion in savings over the next five years.
State governments have readily adopted IT to improve the convenience and quality of services, but few have managed to use IT to reduce costs. The time is ripe for the public sector to fulfill the original promise of e-government by using technology to boost productivity.
The Information Technology and Innovation Foundation has estimated that if state governments were to fully develop IT-driven productivity strategies, they could realize as much as $11 billion in savings over the next five years. Policymakers can develop state productivity strategies in several important ways.
First, perform a formal assessment of all major government functions and identify the ones with the most direct costs (not including transfer payments to others) and those that show potential for productivity improvement. Also, examine potential savings to users to deliver benefits to the broader economy and society overall.
For example, in 2013, Utah began placing sensors along highways to monitor road conditions, track the efficiency of road crews and help divert traffic during emergencies. These sensors not only reduced the costs of weather response, but aided the community by improving safety and reducing the length of road closures, time spent commuting and fuel costs. In fact, the sensors helped reduce car crashes in Utah by 39 percent. When evaluating IT investments, policymakers should look for this kind of enhanced overall productivity.
Achieving productivity through IT cost-cutting doesn't mean scrimping on needed investments. In many cases, governments will need to spend more on IT to save money elsewhere. Many states need to modernize their IT infrastructure by adopting new and innovative technologies. North Carolina took this idea to heart with its Innovation Center program, which allows state employees to test different technologies before adopting them for wider use.
Productivity strategies should focus on using technology to cut costs across government, including labor costs. State leaders often do not want to commit to IT-generated cost savings, in part because achieving them can require workforce downsizing, something that is often politically challenging. As a result, government officials tend to make the case for increased government IT investment based on improving the quality of services, rather than on reducing direct costs.
Track annual productivity gains across all government services, and reward employees who helped make the gains possible. Policymakers should spur the state to develop its workforce culture into one of continuous improvement and productivity, producing reports on the improvements, cost savings and the overall productivity of the state each year. For example, Minnesota's Office of Continuous Improvement awards employees who find ways to reduce waste, cut costs and make state services work better for Minnesotans.
Finally, states must grant the CIO the authority to oversee comprehensive IT-enabled productivity strategies. CIOs need to be more than just IT managers focused on outcomes. They need to be able to craft IT-based re-engineering and productivity plans, with an eye to improving efficiency across all state operations.
Now is the time to fulfill the original promise of e-government: not only to provide better and more convenient services, but also to drive productivity in state governments and economies. By committing to IT-enabled productivity strategies, policymakers can keep that promise.


If you have shopped for a mortgage in the past, then you know how confusing the loan process can be. Loans come with a variety of fees, interest rates, and closing costs which makes it difficult for many consumers to compare rates. In the past, many people have been surprised to find that their closing costs that were quoted with a specific rate had changed substantially and if they wanted to go thru the closing, they had to come up with the extra cash or their loan was not going to get approved.
As of Jan 1, 2010, new federal rules adopted by the Department of Housing and Urban Development went into effect and are designed to protect the consumers. With the new rules, lenders who lowball fees and/or "surprise" buyers at the last minute with extra fees, will have to pay these fees instead of the consumer.
The new rules require lenders to provide borrowers with a standardized three-page Good Faith Estimate (GFE) within three days of an application. This good faith estimate allows for easy comparison of different mortgage options by standardizing the fees on the estimate.
There are certain fees that cannot change from the Good Faith Estimate to the final Settlement (HUD) Statement. These include the loan origination fee, discount points, underwriting fees and transfer taxes. Additionally, mortgage brokers are required to disclose their commission on the good faith estimate. This is reflected as a credit to the borrower.
It is important to realize that the quoted third party fees can change up to 10% from the good faith estimate to the final Settlement (HUD) Statement: These 3rd party fees include appraisal fees, credit report, flood search fees, title services (attorney fees, title search, title insurance), and government recording fees.
There are also some other fees that can change from the good faith estimate to the final Settlement (HUD) Statement. These are typically prorated interest for the partial month and funds required for escrow (for taxes and insurance).
The good faith estimate also provides a summary of your loan terms, including the loan amount, term, interest rate, principal and interest, settlement charges, pre-payment penalties, if any, and whether your interest rate or monthly payment can change.
It may still be difficult to understand all of the components of the good faith estimate. It is recommended that you take the time to understand the various components of your mortgage, so that next time when you are at the closing table, you will find it much easier to compare the quoted fees to the actual charges. Your mortgage lender can help!