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Overcoming the Small Molecule Bioavailability Challenge
Approximately 90% of preclinical compounds are estimated to face bioavailability challenges.
Mogene
Regis Custom Pharma
Softweb Solutions
Vetio Animal Health
David Lyon, Sr. Research Fellow, Lonza Pharma & Biotech10.15.19
The overarching social goal of the pharmaceutical industry is to bring benefit to patients as rapidly and safely as possible. However, with disease targets, active pharmaceutical ingredients (APIs) and drug delivery technologies all becoming increasingly sophisticated and complex, getting drugs to patients quickly has become more difficult. Compounds that fall into Biopharmaceutical Classification System (BCS) II/IV regions—low-solubility and permeability compounds that require more intensive delivery efforts—are becoming the rule rather than the norm. Some 90% of the preclinical compounds are now estimated to have bioavailability challenges.1
Other shifting market factors include the rise in specialty applications for drug products in developed markets. Specialty drugs accounted for 39% of global sales in 2018, and are expected to be more than 50% of the U.S. market by 2023 (IQVIA analysis specialty segment versus traditional; MIDAS Q4 2018 data). Meanwhile, orphan drug products exceeded 50% of new compounds approved by both the U.S. Food & Drug Administration (FDA) and the European Medicines Authority (EMA) in 2018, and are expected to account for approximately two-thirds of the FDA's forecasted approvals through 2023. Also, an increasing number of small biopharma companies are commercializing their own compounds; 58% of 2018 FDA filings were from small companies, almost twice as many as in 2011 when only 31% of filings were from the small company category (IQVIA MIDAS restricted MAT Q4 2018; FDA; Clarivate Analytics Cortellis). Establishing market position can be especially critical for small biopharma players, but these smaller companies typically have limited capabilities in-house and require both development and manufacturing partners to progress their compounds.
These trends have amplified the need for access to bioavailability-enhancing technology and rapid development and commercialization of drug products, which can be especially critical for drug programs with orphan or break-through designations and those following the 505(b)(2) pathway. Critical aspects for meeting bioavailability challenges rapidly include: 1) the ability to rationally choose drug delivery technologies early in the development process (technology selection) and, once clinical success is demonstrated; and 2) the ability to scale that formulation to the next phase (science of scale). Minimizing company-to-company transfers is an added potential time saving; a recent Tufts study2 suggests that as much as three-to-four months can be saved in progressing a compound using a single provider of API and drug product vs. using multiple partners.
Drug developers and patients can benefit from strategies that help overcome the bioavailability challenge quickly and effectively, as well as working with one partner to optimize a formulation, progress their compound through clinical trials and rapidly scale the drug product to launch.
Methods to Decrease Timelines to Clinical Evaluation and Product Commercialization
Technology Selection. The key to rapid and accurate technology selection is using tools to determine the small molecule characteristic, or "problem statement," that is leading to poor exposure. By first understanding which limiting mechanism is at play, the best technology can be deployed without spending time and API testing different technologies.
For example, if a compound is determined to have poor exposure due to a slow dissolution rate, micronization can be employed to increase its dissolution in crystalline form. Conversely, if a review of a compound shows that it needs improved solubility, either a lipid formulation or an amorphous solid dispersion can be utilized. Pharmacokinetic modulation utilizing various controlled release mechanisms in conjunction with solubility-enhancing approaches, e.g., spray dried dispersions, may also be required for formulation refinement in meeting target product profiles.
Utilizing in silico and in vitro formulation and testing methodologies that are highly correlated to in vivo performance3 is also important. Such R&D-derived capabilities may deliver rapid, rational formulations that are predictive of the in vivo outcome, helping biopharma partners quickly and accurately select the most effective bioavailability-enhancing technologies for candidate molecules.
Science of Scale. While optimized technology selection strategies can lead to quicker formulation for clinical trials, it is also critical to be able to progress the formulation to higher-scale production once clinical success has been achieved. Each of the processes that can be utilized to improve bioavailability (e.g., micronized API, lipid formulations, hot-melt extrudates or spray-dried dispersions) is most effective when extensively characterized and modeled using computational fluid dynamic and heat and mass transfer models. By utilizing these models, small-scale fundamental measurements and in silico approaches, the process of choice can be scaled up more successfully.4
First-in-Human Service Packages. To aid biopharma companies in rapidly progressing compounds to first-in-human studies, contract development and manufacturing organizations (CDMOs) have launched a range of service packages incorporating API manufacturing and drug product development. For example, SimpliFiH Solutions, a service from Lonza specifically designed to address bioavailability-challenged molecules, has been designed to progress such molecules to Phase I trials in 32 weeks or less. The SimpliFiH offering is centered on technology selection methodologies and models developed from the experience of advancing thousands of compounds through particle size reduction, solid dispersion technologies and lipid-based formulations to address dissolution rate or solubility issues.
In addition to addressing bioavailability challenges, the service includes a continuum of optional services that can be tailored to specific molecules and drug programs—to simplify the customer experience in reaching Phase I trials. Elements include solid-state characterization, formulation and good manufacturing practice (GMP) manufacturing of Phase I drug product, development of relevant analytical methods, stability studies and documentation for IND studies. API, inclusive of highly potent API, can also be developed and supplied as part of the service package. Lonza's network has a line-of-sight to commercial manufacturing without the need for external process transfer, reducing the need to re-develop API synthesis routes, formulations and analytical methods for each and every phase of development.
As part of the its SimpliFiH Solutions, Lonza has worked to ensure that all aspects of the service offering are phase-appropriate, e.g., streamlined quality and commercial agreements, and aligned with the range of needs facing biopharma companies in reaching IND/IMPD studies. The ultimate goal of the service package aims to generate patient benefit by helping to accelerate clinical evaluation of new compounds, especially bioavailability-challenged molecules which dominate today's development pipeline.
Kalepu S. and Nekkanti. V., Insoluble drug delivery strategies: review of recent advances and business prospects. Acta Pharmaceutica Sinica B 2015 (5) 442
DiMasi, J.A. and Getz, K.A., Analysis of Review Times for Recent 505(b)(2) Applications. Therapeutic Innovation & Regulatory Science 2017; 51 (5): 651-656
Stewart, A.M., Grass, M.E., Mudie, D.M., Morgen, M.M., Friesen, D.T., and Vodak, D.T., Development of a Biorelevant, Material-Sparing Membrane Flux Test for Rapid Screening of Bioavailability-Enhancing Drug Product Formulations. Molecular Pharmaceutics 2017 14 (6), 2032-2046
Dobry, D.E., Settell, D.M., Baumann, J.M., A Model-Based Methodology for Spray-Drying Process Development. Journal of Pharmaceutical Innovation (2009) 4: 133
Prevail, Lonza Enter Development and Mfg. Alliance
Anti-Counterfeiting in the Pharmaceutical Industry: An Evolution
Guidelines in Toxicology: A Blessing and a Curse
Pharmaceutical Process Validation: Product Quality, Safety and Efficacy
Knowledge Sharing: Biologics Development and Delivery
API to ADC: A Journey Through High Potency
Four Pitfalls to Avoid When Packaging Injectable Drug Products
Growth in Biologics and Maintaining Patient Satisfaction
Omeros, Lonza Enter Commercial Manufacturing Agreement
Lonza Selects Rockwell Automation for Digital Pharma Ops
Instead of closing its doors on China, Western pharma industry needs to take a balanced approach and perform proper due diligence based on objective criteria.
Michele Jermini and Enrico Polastro 11.17.20
Clinical Trials | Information Technology | R&D
The life sciences industry is giving clinical a full makeover, dramatically improving how new therapeutics are developed.
Nick Moss, Vice President of Analytics and Machine Learning, Medable 11.17.20
Drug Delivery | Injectables
Bringing together self-medication with auto-injectors and sustainable secondary packaging.
Matthias Heinrichs, Head of Product Management and Project Engineering, Syntegon Technology 11.17.20
Adoption of single-use technologies has increased markedly in recent years and will continue to grow.
Mark A. Sitcoske, Founder & CEO, High Purity New England 11.17.20
Lonza's Director of Commercial Development, Sean Diver, was recently named President of DCAT.
Tim Wright, Editor, Contract Pharma 11.17.20
Biologics, Proteins, Vaccines | Biosimilars | Drug Development
The biopharmaceutical contract manufacturing market is projected to reach $6.3 billion in 2020, and it will continue to grow over the next five years.
William Downey, HighTech Business Decisions 11.17.20
The rapidly changing landscape of pharmaceutical packaging.
Marcelo Cruz, Director Business Development and Marketing, Tjoapack 11.17.20
Cold Chain Management | Supply Chain
There is a growing need for convenience through Direct-to-Patient and Direct-from-Patient services in clinical trials.
Vince Paolizzi, Director of NanoCool Sales, Pelican BioThermal 11.17.20
Biologics, Proteins, Vaccines | Inspections | Supply Chain
Preparing quality control processes for COVID-19 vaccine candidates.
Dr. Andrea Sardella and Raffaele Pace, Stevanato Group 11.17.20
Scale-up/Technology Transfer
Defining the key parameters and considerations for a successful technology transfer.
Tom Chang, President, Bora Pharmaceutical Laboratory Co. Ltd. 11.17.20
Identifying, assessing and mitigating threats at every stage of the development pipeline.
Joe Willmot, Application Leader, H.E.L Group 11.17.20
Clinical Trials | Information Technology
The Role of Electronic Monitoring in Maintaining Medication Adherence
Digital solutions offer hope to get patients to take their medications properly.
Bernard Vrijens, Scientific Lead, AARDEX Group 10.14.20
Understanding the Importance of Crystallization Processes
Crystallization is a crucial aspect of a molecule's development and can be used to avoid unnecessary cost, risk and development delays.
Dr. Craig Callahan, Project Scientist, Cambrex Edinburgh 10.14.20
Capsules | Solid Dosage/Creams/Ointments
Capsule Technology Trends
A look at the capsule market with a particular focus on the factors driving increased demand in non-gelatin-based formulations.
Julien Lamps, Product Manager, Lonza 10.14.20
Aseptic Processing | Fill/Finish
A Holistic Cleanroom Concept: Higher Quality and Greater Flexibility
Overcoming today's aseptic fill-and-finish process challenges.
Ute Schleyer, Project Manager, Site & Plant Development, Vetter 10.14.20


Each lesson, members work towards developing and improving their swimming and lifesaving skills to achieve their personal best. It is an excellent program for participants to keep interested and active in aquatics, especially quick learners and those caught between levels and programs.
Many skills can be recognised with the appropriate Royal Lifesaving award certificate. This is a great stepping stone towards getting involved in Lifesaving as a sport, or becoming a lifeguard or swimming instructor. An opportunity to further develop swimming skills at the same time as developing new and challenging lifesaving skills. Achievements are recorded in each member's personal Waterlog.
Who can join? For children aged 8-15 (recommended for members to pass stage 8 as a minimum).
Kids learn skills that could one day save a life.
Great program for friends and siblings.
Leadership development – decision making and teamwork.
Interested? Visit our Swimming Lessons page for timetables and enrolment forms.


Probably the most affordable restaurant in Tokyo. They offer a 10 course menu for 5000 yen and a wine paring set for another 5000 yen, without compromising with the high standard!
The decor is extremely minimal, so much so that you won't even see cutlery on the table. It is hidden away for you to get. This lack of ornaments (yet pleasant) will let you focus on the food prepared by young chef Daisuke Kaneko who trained extensively in Paris and brought his learnings back to Japan. He learnt very well and added an elegant Japanese touch to his dishes.


Living 200 miles from New York City means that trips to Manhattan generally result in an overnight stay. Based on previous experience cheap hotels in the city can be pretty grim so any stay can get expensive very quickly. As a result, trips to New York are only occasional despite its relative closeness. I'd thought my restaurant-based trip in May was going to be the only one this year.
But another kid has reached the point where they're considering where to go for university. And they're basing their choice on minimising costs by going to state universities. This has the perk that college visits include campuses that are in touching distance of Manhattan so the evenings on those trips can be used trying out new eating places.
Week 1 was a visit to SUNY Purchase, north of the city and we used the excuse to head into the city for a long weekend. The casual approach of Alder was a highlight for me in May so it seemed an ideal candidate to take a teenager to. The chance to try innovative dishes that seemed "familiar" but reveal more as you eat them was a good fit for an evening out.
One slight change since May is that Alder now accepts limited reservations due to Wylie Dufresne's recognition that a no reservation policy only works if you're flavour of the month. It was noticeable on this visit that although the room was dimly lit the tables round the perimeter of the room had a well set light above them so the food was well presented.
Consistent with my first visit, chopped pickled vegetables were brought to the table. Onion and cauliflower with chilli and garlic were the standout ingredients and the blend was every bit as tasty as I remember although it might be good if Alder also provided crackers or bread to spread it on. Our first order dish to arrive was the dish of pigs in a blanket with Japanese mustard and sweet chilli sauce. These are made by running a Pepperidge Farm hot dog bun through a pasta machine then wrapping it round Chinese sausage and deep frying it. These are tasty bites benefitting hugely from the sauces and this was dish where my son outmuscled me to grab more of them.
Cured Spanish mackerel with hazelnut Massaman purée, grape salad and lovage was my starter of choice. Spirals of tender Spanish mackerel were superb with their oily but not overly strong mackerel flavour. The hazelnut Massaman added a nice smoky touch to compliment the fish with the grapes kicking in a juicy freshness.
Next up was the dish we added as an afterthought but turned out to be my personal highlight and possibly the best dish of the weekend. My mental image of French Soup Onion rings was of rings that had a liquid centre akin to a soup dumpling. The Alder version was more intriguing and more satisfying for it. The rings themselves were fairly conventional with gloriously juicy onion in a crisp battered shell. This was topped with melted Gruyere holding the rings together. The stock of the French soup was represented by a thickened beef gravy underneath the rings that had a wonderful bovine kick that sent everything up a notch. For me, this was the perfect snack food. Clever but so, so satisfying.
My son's chosen main was fish and chips with a sweet pea and ramp tartare sauce. This dish used dogfish as the main ingredient and it was full of flavour. The small deep-fried potato cubes were lovely too. But the highlights were in unexpected places. The tartare sauce was excellent, striking a chord with a kid who wouldn't go near normal tartare sauce and the tart vinegar powder was awesome. I was sampling it long after the rest of the dish had gone.
I chose to go with beef tongue, smoked yucca, pickled cippiolini and chimichurri dashi. I was leaning towards this because I haven't eaten tongue for years and I'm always up for retrying things. The group of three people sharing our table rated it really highly so peer pressure kicked in and I went for it. I didn't regret the choice at all. The slivers of tongue were tender with a subtly rich flavour and the pickled onions were the perfect accompaniment. The surprise of the dish was the smoked yucca cake underpinning the meat that gave a starchy counterbalance to the meat. With the savoury broth rounding things out, I enjoyed this a lot.
As on my earlier visit the limited dessert menu didn't appeal. My son chose to go for the root beer pudding with smoked cashews. His take was that he loved the light frothiness of the main pudding and the combination of cashew and root beer candies adding a level of crunch. I had a taste and hated – not because there was anything wrong with it but the intense root beer flavour was something I couldn't deal with.
After two visits Alder is right up there amongst my favourite New York places. I've seen mixed reviews but the food has struck a chord with me and on this visit it worked for my son too. Reserving a table meant we ended up sharing a bigger table between two parties but this worked out well because we ended up comparing notes on what we were trying. If I hadn't seen the other group eating the onion rings then I would probably have ignored them on the menu.
And it comes back to the onion rings. I'd never expected to spend a weekend in Manhattan and come home raving about onion rings above everything else but that is exactly what happened. If you don't feel like a full meal order a couple of cocktails and the onion rings and you'll be doing well.


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Reading: 25 BEST RPG Games: Top Picks (2023)
WhatIfGaming > Gaming > 25 BEST RPG Games: Top Picks (2023)
25 BEST RPG Games: Top Picks (2023)
RPGs everywhere!
Ali Hashmi Published January 6, 2023
Some of the best RPGs you can play right now. Disco Elyisum, Divinity OS 2, Mass Effect Legendary Edition
RPG is one of the most beloved genres in the world. We've prepared this list of twenty-five best RPG games to play in 2022 for your consideration, with some honorable mentions, as well as there are more than just 15 good titles out there.
While our previous list of 25 best PC games to play with friends was focused more on multiplay, this one goes either way. A lifetime of gaming teaches you to appreciate both, and here's what else we've learned along the way.
What Makes A Good Role-Play Game?
The genre changed the game forever, pun intended, when developers adapted it to video tech. The concept's origin is still unresolved, for it borrows much from war games, like chess. However, many agree that Gary Gygax and Dave Arneson popularized it when they came up with the table-top system Dungeons & Dragons back in 1974.
It was during the '70s that RPGs found their way to computers as well in the form of "pen-and-paper" adventures. Later, games like Ultima, Wizardry, Dragonstomper, Bokosuka Wars, and others came out and were some of the best RPGs of their time.
Slowly but steadily, the genre hallmarks formed between the '70s and the '90s, and they included:
A well-developed story
An interesting setting
Exploration and Quests
Experience and Character progression
Weapons and Items
These remain as such to this day, but developers are constantly attempting to make something new or their interpretation of the traditional gameplay mechanics to give their games a unique flair.
These 15 best role-playing games have managed to take the traditional concept, add their unique take on it, and create a thrilling, engaging, and rewarding experience for the player.
Deciding how to rank them is challenging, as we must include both the public and personal opinions into account.
The Witcher III: Wild Hunt
Image Credit: CD Projekt Red
Platforms: PC, PlayStation 4, Xbox One, Nintendo Switch (PS5 & Xbox Series X/S in Q4 2022)
It's hard to write a list without this modern classic, and it's a game that finally allowed CD Projekt Red to garner a mainstream audience. The Witcher 3 continues to impress us, and there's nothing else really like it.
The Witcher 3 follows continues the story of Geralt of Rivia, who is tasked with searching for his ward, Ciri. During his search, he'll encounter many characters, new and old, political figures, and tons of monsters to not only chop down but help as well. Despite being the third entry, it's actually a pretty good entry point for the series, and with the recent next-gen update, it's certainly an excellent time to jump in.
The Witcher 3's strength lies in its writing, side quests, exceptional music, and incredible visual variety. The world is a treat to explore, and almost nothing in it feels padded on content. Every single side quest is handcrafted, and some of the best content presents itself when you're not even looking for it.
There are also two expansions, Hearts of Stone and Blood of Wine. Both of these, in my opinion, are even better than the main game's quest. Blood and Wine introduces a whole new area where you can easily spend an additional 30-40 hours in. Witcher 3 routinely goes on sale for very little, and no matter what you pay for it, you won't be disappointed.
Image Credits: Nintendo
Platform: PlayStation 5, PlayStation 4, Xbox Series X | S, Xbox One, PC, macOS
Disco Elysium is a work of art. Set in the fictional city of Revachol, players take on the role of a detective sent to investigate a murder with the help of gaming's best side character, Kim Kitsuragi. Disco Elysium doesn't have any combat, and it's entirely driven by dialogue and investigation.
Its writing is simply unmatched, especially in the video game genre, with depth to rival most literary works. Each voice in your head is essentially an upgrade path and factors into skill checks that happen during the conversation. There's also a thought cabinet where you internalize different ideas and concepts to improve your understanding of the world further.
Disco Elysium will hook you within seconds and make you laugh and cry, but it will never bore you for a single moment. It's an experience that pushes the medium forward with its beautiful art direction, incredible writing, and extremely memorable score. Did I mention how much I love Kim?
Image Credits: Bandai Namco
Platform: PlayStation 5, PlayStation 4, Xbox Series X | S, Xbox One, PC
Elden Ring is FROMSOFTWARE's Magnum Opus. This is what a decade of action RPG releases was leading up to, and it earned every bit of hype and more. Welcome to the Lands Between, a world full of mystery at every corner, dangerous enemies with enough variety to rival any RPG, and some of the most difficult but awe-inspiring bosses you'll ever encounter.
There is a ridiculous amount of variety in character customization, with hundreds of weapons, spells, incantations, and summons to discover. You have the freedom to change your build and character too, with nothing holding you back. If you're tired of being a greatsword user, fret not, because you can respec to a sorcerer and literally call the down stars to aid you. Traversal is fast because your astral companion and the sense of discovery and scale are unmatched.
The map isn't littered with icons, and Elden Ring trusts players to explore on their own, with nothing but their own curiosity. Breath of the Wild is an obvious inspiration, Elden Ring elevates the formula by cutting out things that can get in the way of player exploration, and despite its incredible scale, makes the entire experience accessible enough too.
Divinity Original Sin 2
Platform: PlayStation 4, Xbox One, PC, Nintendo Switch, iOS
Larian Studios launched the first Divinity Original Sin back in 2014, but it's the sequel that really knocked it out of the park. Divinity Original Sin 2 is one of the best modern RPGs of the past decade and offers a wealth of content that will keep you hooked for dozens of hours. If there is one particular theme that resonates throughout basically everything mechanical system, it's freedom. Whenever you ask yourself, "Can I do this?" the answer is almost always a resounding "yes".
There are tons of classes to try out, and the game's flexible respec system allows you to change the way you play after you've reached a certain part. The "Origin" characters are all great, but if it's your first time, I really recommend giving Fane a shot. His undead nature means you'll be at a slight disadvantage initially, but his story is excellent and far more overreaching than anyone else.
Divinity Original Sin 2 rivals Witcher 3 when it comes to the side content, and the way it intervenes in the main narrative is something I've rarely seen done right. The combat is turn-based in nature, but its reactive nature of it with the environment makes you account for multiple things, like how wet surfaces can conduct electricity or how oil can cause explosions. It's one of the most refreshing combat systems ever, and we're super excited about Larian's upcoming title, Baldur's Gate 3.
Platform: PC, Xbox One, Xbox Series S|X, PS4, PS5
A trilogy that needs no introduction. Mass Effect Legendary Edition collects three of Bioware's finest science-fiction RPGs with remastered visuals, quality-of-life features, HDR support, and improvements to practically every part of the presentation. Players take on the role of Commander Shepard, who leads the Normandy crew on an unforgettable journey in one of gaming's finest space operas.
Bioware has yet to create something as ambitious and emotionally gripping as the Mass Effect series. To this day, you're hard-pressed to find a sci-fi RPG series as polished, well-realized, and accessible as this. So gather your crew, punch your way through crucial narrative moments, and make sure to soak in the world as much as possible.
The combat improves with each entry, and while the first Mass Effect is still closer to Bioware's roots in terms of inventory management and skill assortment, Mass Effect 2 is where the gameplay truly shines into something special. Your choices throughout the series are maintained, and it's one of the biggest reasons why this series is still so beloved. Every decision you make can shape the narrative in bigger ways than you can imagine, which is Bioware's greatest strength.
Youtube: PlayStation
Demon's Souls was a cult classic that laid the foundation of a genre that many developers have tried to replicate over the past decade. Even though Dark Souls put Hidetaka Miyazaki on the map, I think it's Bloodborne that really allowed him to ascend to the greatest gaming auteur of all time. At its core, Bloodborne is a horror game that routinely subverts players' expectations by going from gothic to nightmare-fueled Lovecraftian horror, especially when you're not looking.
Compared to Dark Souls, Bloodborne's combat is faster, requires an aggressive approach, and rewards careful decisions where taking damage isn't exactly a bad thing. You have a sidearm that serves as a parrying tool, and the lack of a shield takes away a direct form of defense. Bloodborne's thick atmosphere, interconnected levels, and grotesque enemy designs put it in a league of its own, and it's a shame it's still exclusive to the PS4.
Like other Souls titles, it's an action RPG but with tons of build variety, character customization, and combat design influenced by your trick weapons that can shift into different forms at your whim. It's an elegant system, and fighting bosses can almost feel like a dance because instead of dodge-rolling, you're dashing around with grace.
Image Credit: Bethesda Softworks
Platforms: PC, PlayStation 3, PlayStation 4, Playstation 5, Xbox One, Xbox 360, Xbox Series X/S, Nintendo Switch
Skyrim is an obvious choice for the top of any list like this as it is one of the most commercially successful and critically acclaimed RPGs of the past decade. And, we are not judging it only by the numbers – it is a great game and an all-time favorite to multitudes.
The game was developed and published in 2011 by Bethesda. The studio is with The Elder Scrolls franchise since its beginning in the 90s. Their creation deserves first place because they integrated many innovations and progressive ideas into the genre while keeping the traditional things we love in RPG.
Specifically, Skyrim has unrivaled world-building. The way the setting intertwines with the story plot makes the world much more important in this game, and it is also true for previous franchise installments.
Additionally, the game has Bethesda's signature character progression method where you advance in what you use and where the combat system is built around that, allowing the player to utilize everything he does in the game, including reflexes, coordination, character progression, and planning.
It is an experience unlike any other in gaming, rivaled only by previous Bethesda's hit titles. If you don't want to play Skyrim because you've played it too much, you can always turn to The Elder Scrolls IV: Oblivion, which holds its own compared to the successor, and we even made a list to prove Oblivion is good in 2022.
Image Credits: Steam
Platform: PlayStation 5, PlayStation 4, Xbox Series X | S, Xbox One, PC, Nintendo Switch
It wouldn't be a Best RPG games list with one of the best JRPGs of all time – Person 5 Royal. Person 5 was initially released in 2016, and it was a huge hit. The game was later re-released in 2019 as a "Royal" edition, and it was more than just a refresh of the game.
Person 5 is set in modern-day Tokyo, and the story revolves around a bunch of teenagers fighting psychic monsters in the fantasy realm, which took birth from the human subconscious. The group or better known as Phantom Thieves of Hearts, secretly fights threats unknown to the common man.
Person 5 Royal is the sixth addition to the series. Persona 5 Royal received a huge buff to its story, as well as the combat system. Two new characters were added to the "Royal" version of the game. The combat system includes the cutscene-style tag team finishers, which are just cinematic masterpieces.
The story tries to portray some real-world evils through its incredible and immersive art style. The game packs more than 100 hours of content and will surely make you lose a brain cell here and there, but it is surely worth it.
Deus Ex Mankind Divided
Platform: PC, PS4, Xbox One, macOS
Yes, yes, I know this is an "unfinished" game, but Mankind Divided is an extremely underappreciated title. It doesn't always hit the right notes when it comes to its commentary, but this is an exceptional RPG. An immersive sim by design, Mankind Divided is serious about choice and how you deal with missions. If you're sick of RPGs that are set in huge open worlds, and want a more focused experience, then Mankind Divided has you covered.
There is a lot of variety in the world, Prague is a beautifully designed hub world with tons of secrets to explore. The voice acting is great, as always, and the dialogue choices aren't always binary in nature. You can upgrade Jensen in multiple ways, and there's always more than one way to handle a situation. There are a bunch of new gadgets to experiment with as well, and the boss fights don't suck anymore (cough, Human Revolution, cough).
Mankind Divided might end abruptly if you're just doing the main quest, but there's a lot to do in the world besides that. It still looks absolutely fantastic and can run quite well on modern hardware. Now that the dust has settled, this is one of the best RPG games you can get.
Fire Emblem Three Houses
Fire Emblem Three Houses is one of the best tactics RPG titles available for the Switch. It's a game that is only possible after years of refinement in the series. It is something that fully utilizes Switch's hardware to create a tactical RPG with tons of depth, a fantastic cast of characters, and a shockingly engaging story to boot.
Each character in this game is unique, and learning more about them is incredibly rewarding. The conversations are never boring or feel like filler, with some well-written dialogue. The combat retains the complexity the series is known for while adding a few new mechanics of its own, and somehow still feels more accessible than ever. It's more than just combat, though, because managing your time, which is a vital resource here, can sometimes be the only thing standing between victory and defeat.
This is a huge time sink, though, and you're easily looking at 50-80 hours for a single playthrough, but to really uncover everything this game has to offer, you'll need a lot more than that.
Final Fantasy 7 Remake
Platform: PlayStation 5, PlayStation 4, Microsoft Windows
Final Fantasy 7 Remake is a full remake of 1997's classic RPG title, which came out on the PS1. Cloud Strife will return once again to take down Shinra, but this time with a complete visual overhaul and additional story content. It should be noted that this is actually the first part of this remake, as Square Enix has greatly expanded on the original with more context for certain characters.
Minor characters in the original are given a lot of screen time, and their stories are developed into full chapters that further elevate their presence throughout the title.
The combat system has been overhauled as well, with far more depth this time, and even though there is a turn-based mode, too, the real-time addition essentially makes it a new game. Each member in your party has a specific role that you'll understand as you experiment more, and there is a lot of variety in how you can build your characters further.
The debate of whether this is better than the original is one that we don't see ending soon, but if you're a fan of the original, this is an experience that you absolutely can't miss out on.
Image Credits: Square Enix
Platform: Super Nintendo Entertainment System, Nintendo DS, PC, PlayStation, Wii
If there is one game that can be called the benchmark for RPGs in the 90s' then Chrono Trigger certainly stands on top. Released in 1995 by SquareSoft, it was a hit, and to this day it is one of the most respectable names in the genre.
Chrono Trigger was a hit because of how incredibly detailed it was, considering the game was released decades from today. The game features time travel, where you travel through time and space into different eras. Each era you visit, you pick up a new character for your team. That way, in the end, you become a party of 7.
You go back and forth in time, you do something in the past, and it affects the future. There is so much detail in this game that it is mind-boggling. The character design, the story developed, and the visuals were enough to make anyone fall in love.
On top of everything, the game is also known for its music which adds to the immersion. There is a reason people often refer to the game as one of the best games to have ever been released. The game was originally released for Super Nintendo ES and was later ported to PC and PlayStation.
Image Credits: Fanatical
Platform: PlayStation 4, Xbox One, PC
Monster Hunter games have always been about killing monsters, looting them, upgrading your weapons, then fighting bigger monsters. It's all rinse and repeat. To say that process is repetitive and boring would be the farthest thing from the truth when we are talking about Monster Hunter World.
Capcom has put immense amounts of effort into truly curating a world where everything is perfect to the t. Monster Hunter World's decision to remove the zones from the game and to create overlapping ecosystems was one of the most welcomed changes in the 5th installment of the game. It is the mark of a well-built RPG where the developers have not only put effort into how the world interacts with you but also how the world interacts with itself.
Crafting has been made simpler and much smoother with expansive weapons trees. There are over 14 weapon categories and hundreds of items to craft. The crafting system this time will force you to play multiple quests before you can gather the required items while making the grind a little more rewarding.
The game makes use of the more powerful hardware in more ways than one starting from fluid and faster looting and an open world that is just a treat for the eyes. Story and plot aside, the game will make stand in one spot and just observe everything which is something that makes an RPG experience even sweeter.
Platform: PlayStation 4, Xbox One, PC, Nintendo Switch
Arguably Yoko Taro's most successful title, Nier Automata, is one of the best games of the past decade. This is an emotional experience that constantly surprises you with its characters, story, and a fantastic score. It's hard not to gush over this particular game, but doing so might take away what makes it special. In Nier Automata, you play as 2B, an Android who, alongside 9S, that have been sent to clear out machine threats during a post-apocalyptic proxy war.
The story takes multiple playthroughs to complete fully, and like the Drakengard series, gives players more context in each run. Since Platinum Games developed this, you can expect hack and slash combat, some massive bosses, and just excellent movement all around.
The side quests are excellent and the heart of this game. If you're planning on playing this, I highly recommend doing everything. There is enough variety that you won't be disappointed. This is a game where a director's vision is communicated so well, in not just the story but the gameplay as well.
Source: Nintendo
Platform: Nintendo Switch, Android, PlayStation 4, macOS, Xbox One, IOS, Xbox Cloud Gaming, Windows, Linux, PlayStation Vita
Are you tired of chasing objectives, and constantly losing to a hard boss, and want to try something a bit more laid back? Stardew Valley is exactly what you need right now. The game is so relaxed and chill because there is no losing or game over. You just have to play and have fun.
Stardew Valley started out as a venture by Eric Barone, who wanted to design a game that was much like the Harvest Moon games but better in every sense. It took him 4 years to do that but what came out was a piece of art. The game starts when your character who hates his job, opens up a letter from his deceased grandfather. In the letter, he told him about a piece of land in Stardew Valley.
You leave your job and move to the valley, to take care of an overgrown farm. The game packs a great number of details, character design and story, and fun activities. All of these things are enough reasons to make you play the game. The game is a step away from your usual action RPG genre and dials it down a gear for a more relaxed yet fun experience. Here are a few tips to get you started.
Diablo 2 Resurrected Key Art
Platform: PC, PS4, PS5, Xbox One, Xbox Series S|X, Nintendo Switch
Okay, yes, Diablo 3 is a far more accessible title with deeper mechanics and build variety. It's still supported, and there's always more content to look forward to. However, if you're actually looking for the game that essentially gave birth to darker action RPGs, then look no further than the fantastic remaster of the classic PC title, Diablo 2 Resurrected.
This is one of the best remasters we've seen in a while, and it lets you toggle back to the older visuals with a single button. There's a lot to get through here, and fans of the original will feel right at home. It also has controller support, and it's shockingly good. If you're like me, who prefers playing games with a controller in general, you'll have a hard time returning to the original control scheme.
The world of Diablo 2 is dark and gritty, and unlike its sequel, there are a lot of macabre monsters and a general intoxicating atmosphere that many missed in 3. Diablo IV is aiming to carry that style and looks like a far darker game than 3.
Platform: Nintendo Switch, Wii U
Waking up from a 100-year slumber and finding out you have lost your memories and spending the rest of your time gaining back lost moments. Welcome to The Legend of Zelda: Breath of the Wild. If you are a Switch gamer, there is no way you have never heard of this game because it is hard to mention one without the other.
We are all aware of the Zelda franchise and BOTW was a shining addition to the series with its massive open world, thanks to the 5 years it took to develop. The first thing when you drop into the game is the gigantic map which is all left open for you to discover.
Aside from the main storyline, the game is filled with almost endless puzzles, side quests, villages to raid for treasure, and so much more. You can spend hours in the game and not play the main quest once, that's how much content it offers.
In a sort of fantasy RPG game like Zelda, you don't expect realism but the game surprises you in more than one way. BOTW's world responds in a way that feels natural and much like an actual real-world experience. From objects to creatures, everything has been designed and refined to achieve that goal.
The Legend of Zelda: Breath of the Wild is truly a masterpiece and if you are a fan of RPG and happen to have a Switch then jump right in because you won't regret it.
Image Credit: Ubisoft
Platform: PlayStation 4, PC, Xbox One, Nintendo Switch, Xbox Cloud Gaming
Assassin's Creed Origins was the first title that embraced the new direction for the series, and Odyssey expanded on it exponentially. This is a massive title with a vast open world filled to the brim with content at every corner. Odyssey takes players to Greece during the Peloponnesian War between Athens and Sparta. As usual, despite your indifferent origin, your role in this war, as you work for both sides, dramatically impacts Ubisoft's take on this period, seen through a mythological lens.
Players will either take on the role of Alexios or Kassandra, spartan mercenaries that will take on a variety of missions throughout their extensive journey. Like other entries in the series, the game has multiple expansions that delve deeper into the mythological aspect as well. If you liked Origins but wanted even more, then Odyssey has you covered with its sheer variety of activities you can do.
A standard playthrough should take you from 40 to 80 hours, depending on how many side quests and activities you do.
Image Credits: CD Projekt Red
Platform: PlayStation 5, PlayStation 4, PC, Xbox Series X | S, Xbox One
After The Witcher 3, CD Projekt Red's next project, Cyberpunk 2077, had huge shoes to fill. After years of marketing, cut features, and a poor launch, Cyberpunk 2077 didn't exactly have the best start. It's been a while since that now, and with a number of patches, Cyberpunk 2077 is an experience worth having.
CD Projekt's Red signature writing, memorable characters, and the impressive world make this game finally find its footing. It may not nail the basics of even older open-world titles, but ultimately, like many other RPGs that aren't exactly the most solid in each aspect, Cyberpunk 2077 manages to grow on you with its characters and the sheer variety in side quests.
If you were a fan of Witcher 3's world and its inhabitants, then there's a very good chance you'll like this as well. Just make sure you have a decent enough PC, or you're playing it on current-gen consoles.
Assassin's Creed Valhalla
Image Credits: Ubisoft
There is no way we talk about open-world role-playing games and don't talk about Assassin's Creed. This time we are stepping away from the stealth genre and taking part in some Viking action. Yes, we are talking about Assassin's Creed Valhalla.
Set in 872 AD, the era of merciless Vikings who were ready to settle down in England. Valhalla was Ubisoft's attempt at breaking the stealth genre and trying something different for a change. You will be playing as Eivor Varinsdottir, who is a capable Viking. You can choose to play either as a male or a female.
Ubisoft might have mixed things up a bit, but they still have kept the Assassin spirit alive by keeping a few key aspects in the game. Stealth is still an option even though we are playing as Vikings, who are known to be loud and ruthless, but Assassin's Creed Valhalla still has the option to be silent and discreet.
Along with the great story and combat mechanics of a typical Assassin's Creed game, there are tons of customization options for your character, such as armor, tattoos, beard, and other appearance aspects.
Pillars of Eternity II Deadfire
Image Credits: Pillars of Eternity Wiki
Platforms: PC, PS4, 2Xbox One
The Pillars of Eternity II Deadfire is probably one of the most retro-looking modern-day RPGs. It feels like we are back in the early 00s when playing it. However, don't be fooled because its modern gameplay features, innovative mechanics, and vast content make it one of the best RPG games!
Another thing that sets the PoE franchise apart from others is how the whole story from all installments is connected. And, if you play it all through a single account, your choices from the first game will sometimes affect how things unfold in the sequels.
The Pillars of Eternity II Deadfire is Obsidian Entertainment's pride, a sequel to 2015's first installment, which was a big success. The developers turned to crowdfunding for development, and all it took was one day for it to reach the required budget. That speaks enough of what the fans think of this game.
Image Credit: Blizzard Entertainment
Given up by many but still maintaining quite an active online community, World of Warcraft has grown and improved over the years. It goes for the retail and classic versions both. The improvement is in game design, visuals, and storytelling.
The retail version is getting a new expansion, Dragon Isles, which introduces a new class, new race, and new content, and changes the talent system to incorporate the classic method a bit. The latter is quite a welcomed change in our opinion.
The classic version is available in vanilla, TBC, and Wrath of the Lich King (since September 22, 2022). The fans can relive their favorite moments with "some changes" to gameplay. Blizzard has promised to keep the old gameplay style as much as possible but still introduce some modern improvements that weren't there the first time.
Image Credits: Eve Online
Platform: PC, macOS
If you've ever wanted to play an MMORPG fantasy world like Lost Ark but set in space then Eve Online is what you are looking for. With over 7,000 solar systems to explore and a variety of customizable battleships, EVE Online is one of the most immersive MMOs out there.
The game is notorious for its steep learning curve and its hardcore PVP mechanics. And while many fans have moved on from EVE Online due to its ruthless and seemingly unavoidable P2W mechanics, once you make it past that initial hurdle, you won't ever want to leave.
You will find yourself immersed in the incredibly vast open world, going from star to star, searching for new materials, all while taking part in multiplayer battles. You can put a lot of real-world money to buy the intergalactic spaceship you have been wanting to buy. The game has been left open-ended for the players. The more creative you are the more you are rewarded.
Genshin Impact Youtube
Platform: GeForce Now, PlayStation 4, PlayStation 5, Android, iOS, Microsoft Windows, iPadOS
Are you a fan of anime? Are you a fan of RPGs? If you are a fan of both, then look no further because we have got the fix for you. Genshin Impact is an anime-infused RPG by miHoYo and since its release in 2020, it has caught the attention of every RPG fan.
The game takes place in the magical world of Teyvat which bifurcates into 7 powerful nations. Each nation is ruled by a God and is related to a specific element. You will start as "Traveler" who along with his sister/brother travels different worlds. When you enter Teyvat, you will face a powerful foe and you will be separated from your sibling (You have the choice to play as either sibling). The whole story revolves around you traveling in search of your lost sibling.
Genshin Impact is filled to the brim with content. The world is vast and full of all kinds of activities, quests, NPCs, and other playable characters. The game allows you to create a team of players, all with different elemental attributes, to work together and take down enemies. The teamwork element is something that makes the game much more enjoyable and is one of the reasons why this game is so high up on the list.
This was just a hint of what the game has to offer. Start discovering and you will find yourself going on for days.
Platform: PlayStation 4, PlayStation 5
A sequel is supposed to be better than its predecessor in terms of what the first one lacked. It is supposed to build upon the foundation of the previous installment and take the franchise further. If there is a game that deserves to be called a sequel, then it's Horizon Forbidden West.
Horizon Forbidden West features everything great from the last-gen Horizon Zero Dawn and adds its own new gameplay elements. The game has similar combat and traversal mechanics, a great storyline, and more challenging mechanical foes. On top of all of this, the game now features many settlements across the post-apocalyptic United States. This adds a bit more depth to the game and exciting side quests.
Once again, you will play as Aloy, a member of the Nora Tribe, surviving the ruthless world filled with mechanical monsters and other threats. Guerrilla Games and Sony have outdone themselves with this one. They are also adding new DLC as time passes.
This list of the 25 best RPGs holds many hits that the audiences love but also some that rocked our worlds. Other great titles would be a worthy inclusion, but one can't remember them all!
We can't go on without mentioning these other titles that are some of the best role-playing games ever made. We just didn't have room to include them, like the Dragon Quest, Fallout, Dark Souls, Dragon Age, Neverwinter Nights, Baldur's Gate, and many more.
Finally, at the time of this writing, Baldur's Gate 3 is still in early access, and we assume it will be one of the best RPG games of all time, but that's going on our 2023 list!
By Ali Hashmi
Gaming enthusiast, massive soulsborne fan, and a passionate writer. Always on the lookout for interesting games with unique mechanics and design. He loves to write informative guides for newer and ongoing releases.
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redpajama_set_name: RedPajamaCommonCrawl


Meet my latest rescue Zoe! I found her through Arizona Border Collie Rescue a few months back. She has a pretty incredible rescue story as you can see in the video. We are so grateful to Az Border Collie Rescue and to the Pilots N Paws organization. What an amazing group of people to be so dedicated to these dogs. They go to great lengths to be sure these animals can get to their forever homes. Thank you!! Zoe is such a sweetie – a little mischievous sometimes but so much fun.


Trane American Standard BAYFRAME235A Frame Kit With Filter (AKA FRM01434) fits models: TFM235A0AH1, TFM235B0AH0. This kit includes plastic frame and 1 BAYFTAHEXM expandable accordian filter. Once assembled - it is identical in size to the BAYFTAH23M 5" Box Filter.


text:
featured, Uncategorized
October 19, 2020 Linda Hirst
Our new work in collaboration with Chris Amemiya's lab at UC Merced demonstrates the presence of Chitin in an unexpected place – the electro sensory organs of cartilaginous fishes.
Molly Phillips, W. Joyce Tang, Matthew Robinson, Daniel Ocampo Daza, Khan Hassan, Valerie Leppert, Linda S. Hirst, Chris T. Amemiya,
"Evidence of chitin in the ampullae of Lorenzini of chondrichthyan fishes", Current Biology, Volume 30, Issue 20, 2020, Pages R1254-R1255,
https://doi.org/10.1016/j.cub.2020.08.014.
Read a news article here
https://news.ucmerced.edu/news/2020/hard-shells-and-electrosensory-gels-lab-makes-surprising-discovery
Abstract,We previously reported that the polysaccharide chitin, a key component of arthropod exoskeletons and fungal cell walls, is endogenously produced by fishes and amphibians in spite of the widely held view that it was not synthesized by vertebrates [1]. Genes encoding chitin synthase enzymes were found in the genomes of a number of fishes and amphibians and shown to be correspondingly expressed at the sites where chitin was localized [1,2]. In this report, we present evidence suggesting that chitin is prevalent within the specialized electrosensory organs of cartilaginous fishes (Chondrichthyes). These organs, the Ampullae of Lorenzini (AoL), are widely distributed and comprise a series of gel-filled canals emanating from pores in the skin ( Figure 1A). The canals extend into bulbous structures called alveoli that contain sensory cells capable of detecting subtle changes in electric fields ( Figure 1B) [3,4]. The findings described here extend the number of vertebrate taxa where endogenous chitin production has been detected and raise questions regarding chitin's potential function in chondrichthyan fishes and other aquatic vertebrates.


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Truck Drivers on Strike in Iran Over Low Wages
June 5, 2018 • by AF Staff
An Iranian border guard supervises the passage of trucks, full of manufactured goods and produce bound for the Shalamsha Port of Entry near Basra, Iraq,
Photo by Alan S. Brown, U.S. Army/Wikimedia Commons.
Truck drivers in several Iran provinces are on strike over low wages, a movement which first began in May.
A semi-official news agency in Iran reported the strike on May 23, according to the Associated Press. The strike is taking place in provinces of Fars, Hormozgan, Isfahan, Kerman, Khorasan Razavi, Lorestan and Qazvin, and began as a reaction to driver's complaining their wages are not enough to cover their expenses, according to VOA News.
The nationwide strike has been underway for approximately two weeks, despite not having a union, according to Al-Monitor. The drivers also called for higher pensions, better health insurance, and cheaper truck repair facilities.
Read more about Global Iran Drivers
Global Fleet Market Reports
January 2019 Edition
September 2018 Edition
May 2018 Edition
Ask the GM Global Fleet Experts
Australia &
Stuart Adams
Brian Luo
Yuri Tello
Anton Glenn
Nicole Daugard
Mexico &
Seyar Shunnar
Eduardo Freitas
Peter Cornu
China, Europe Expected to Lead Global Biodiesel Market
The global consumption of biodiesel is expected to register a 3.1% compound annual growth rate (CAGR) between the period of 2018 to 2026, bolstered heavily by growth in Europe and China.
AstraZeneca's Global Fleet Transitions to EVs
AstraZeneca is transitioning 16,000 vehicles in its global fleet to battery-electric assets following the company's move to join the EV100.
Argentina Commercial Sales Down in June
Sales for light- and heavy-commercial vehicles in Argentina were down in June by more than 40% for both segments.
South Africa FMC Acquired for $222M
South African based fleet management company Eqstra Fleet Management and Logistics was acquired by a services, trading, and distribution company in the region for $222.34 million.
Ford Leads Vincentric's Canadian Best Fleet Values for 2019
Ford received the most honors for Vincentric's eighth annual Best Fleet Value in Canada awards, which was bolstered by the success of the F-Series Pickups.
Editorial Insights
Venezuelan Authorities Seize GM Plant
In Memoriam: Founder of Canadian Automotive Fleet Magazine
Country Focused Profiles
GM Expands Vehicle Software Development and Engineering in Canada
Kia Invests in Mechanic Training in Ethiopia, Kenya
Toyota Delivers First Mirai Fuel Cell in Belgium
McNeilus Refuse Trucks to be Offered in Saudi Arabia
U.K. Fleet Accident Management Company Expands Board
A United Kingdom-based fleet accident management provider has named a non-executive chairman to the company who will offer guidance on its strategic direction
German Light Commercial Vehicle Registrations Up in 2019
The light commercial vehicle market in Germany was up by 12.3% in the first five months of 2019 when compared to the same period of time last year.
Element-Arval Global Alliance Names VP of Global Business Development
The Element-Arval Global Alliance has named the vice president of global business development for its global team, who will support multi-national accounts between different countries.
Global Telematics Market to See Growth Over Next Five Years
The global telematics market is expected to grow at a compound annual growth rate (CAGR) of 20.7% over the next five years, with developments in North America leading the way.
Australian Commercial Vehicle Sales Up in May
Sales of commercial vehicles, and heavy-commercial vehicles, in Australia were up in May compared to the previous month, though the percentages are down when compared to the same time last year.


"I'm Not Happy" was a series at Kaleo discussing the topic of Joy. While brainstorming this series the creative team at Kaleo and I decided it would be fun to use pictures of people who looked happy to contrast the title.
I stumbled on to a lot of 50′s and 60′s advertising and decided to use it to create the look for this series.


Skip To My Lou has a cute pleated pouch she is sharing with us. Just another thing to add to the ever growing list....so skip across and take a look.
While you are there she has other tutorials but I noticed an apron that would be easy enough to whip up.
Noodlehead has a really nice Gathered Clutch Tutorial lots of pictures and it really is something a bit different. I think I need one of these for sure.
Janet from JMD designs has shared a nice Needle Pad tute and has the instructions on how to do the Buttonhole Stitch with Picots that she has used on the design, might have to try this would look nice on felt pincushions as well.
There are also lots of other freebies here, on Janet's site, check out the fingerless gloves, I need to talk my sister into making me a pair of these for winter.
Embroider a floral heart in RedWork and finish as a pretty pin cushion or sachet!
Click Here to download and don't forget to check out past free designs on the link on left.
I have just put up a tote bag tutorial/PDF free pattern on my Sew Prim Khris blog to download.
This tote bag is done slightly different to the standard tote where you make the outer bag and then the lining and pop one inside the other. You actually sew one lining to one outer fabric and then sew them all together after putting on pockets and handles.
Sandi from Embroideroo has a cute strawberry pincushion she is sharing with everybody. A heap of these in a bowl would be so cute.
Prim Patterns 'n Handmade has a prim teddy pattern to grab. You don't have to make it prim of course. Looks like a versatile style of teddy to make using all sorts of fabrics. If the link doesn't work I noticed Denise has also another site with the free pattern called The Krazy Kraft Lady.
Sue has quite a few stitcheries and other freebies she is sharing over at Free Stitchin' Patterns if you want to take a look there are things for Easter, Halloween and Christmas.
Tennessee Ridge Primitives have a new freebie up. She changes these regularly so you have to drop back for new ones. At the moment it is a great prim rabbit.
Moonchilds Primitives have free patterns that she changes often so drop over and grab the current pattern. At the moment it is a nice prim round head butterfly doll.
Raggedy Old Annies has the cutest bunny pattern she is sharing with everybody. I think this is definitely another must do for me.
There is a free pattern on Flickr for a prim bunny...of course you don't have to make it prim if you don't wish to.
All People Quilt have a nice pattern for a tote called Trim it Tote. A clever way to make a plainer piece of fabric into a more interesting tote.