The picture that fronts the Nordic Hair Awards, the girl in the winning pose with braids at the back of her head, is created by Annie Ankervik, Swedish award-winning hairstylist, educator and co-founder of Kollektivet KAI The idea behind the collection, which the picture is a part of, came from Annie's fascination for nature's repetitions, or fractals as they are called.
– If you look at a fern you see that the big leaves are made up by small leaves in the same shape, it all repeats itself. They are fractals.
During the past three years Annie has been focusing on mastering her braiding techniques. She wanted to take her braiding to the next level by creating a collection.
– Braids are all about repetition. If you learn how to make one lap of a braid you just need to repeat it over and over again. When I look at the braided hair styles that I did a couple of years ago, I can see that I have made quite a big journey. Back then I thought that I was braiding very small braids, but now I start my three strand braids with literally three hair strands.
Braids have been seen a lot during the last few years and Annie has developed her skills in doing them in different patterns, styles and techniques. Last year she entered a contest with a hairstyle consisting of braids solely in the back of the model's head.
– I thought it would be fun to do something different compared to what I usually do. All braids don't have to be in the forehead or around the face.
The same kind of backwards hairstyle, featured in a different way, is now the front picture for Nordic Hair Awards. Annie describes the look as something like an 80's mullet; business in the front, party in the back! And we love it.
1. Take all your creative ideas and break them down into one, so that there isn't too much of everything.
2. Be true to yourself throughout the whole process. Follow your own instinct and don't think about what the jury would like. In that way, no matter the result, you will be proud of what you have created.
3. Gather a team of competent people who can contribute with their expertise. It's your vision that is created but at the photo shoot, you can't focus on everything. Through collaboration, dialogue and by giving each other creative space, everyone involved can get a lot of experience and material from the photo shoot.
4. Choose a perceptive photographer. The photographer's ability to see the full picture and interpret your ideas in a way that you are comfortable with is important. The photo shoot doesn't have to be in a studio, but the photographer should have knowledge about lightning to be able to portray the colour nuances in the right way. Try different lightings and find the one that suits the specific hairstyle the best.
5. Choose the right model. For us, it's not about finding the prettiest model, but a model with character and the ability to convey the feeling you want to express in the picture.
6. Create a mood board to visualize your inspiration. Expand the mood board to communicate your inspiration and the feeling that you want to express in your picture to the other members of the team. Note that the mood board is inspiration, not instructions.
7. Think through all the steps and details before the photo shoot. Through being well prepared you can be creative on set. Even though you have planned and decided everything beforehand a lot will change during the photo shoot and that's when it's important to stand on solid ground.


You are here: Home / Beverages / The Detox Shopping List You Need for Success!
Like most endeavors in life, a key to success is planning. Before I began my detox diet, I did some quick meal planning so I would have plenty of go-to foods during my detox. One thing I've learned over the years: if I set myself up for success, nine times out of ten, I succeed. So I try to help out my future self whenever possible.
We've all heard it a thousand times: If you fail to plan, you plan to fail.
On any given day, meal planning definitely attributes to the healthy habits I'm trying to teach my family. When I don't take the time to meal plan, I feel stuck, overwhelmed, and a healthy dinner doesn't happen. Planning doesn't have to take long and you can allow for flex days where you're not sure if you'll be home for dinner or not. I typically plan 3-4 meals a week and then we eat leftovers 1-2 nights, or eat out if we happen to be out and about during dinner time.
If you are looking for an online tool that makes meal planning a breeze, I highly recommend PlantoEat.com. Import your recipes, drag them onto your calendar, and a shopping list is automatically generated for you. You can print the list or sync it with your phone and then head to the store armed and ready. You can also group recipes into menus to re-plan them anytime, making planning so quick and easy. I absolutely love it!
TIP: Shop for organic products whenever possible.
Do you have a go-to healthy food list? Please share in the comments below!
I'm feeling really energized today—I think my body is getting the hang of this detox thing.
Wins: I made it out for a walk after lunch. It always lifts my spirits, clears my head, and I get the best thinking done when I'm out in the fresh air!


My client, a manufacturer based in Halstead, are seeking a customer service administrator to join their team.
This role is for an enthusiastic and dedicated Customer Service Administrator who will provide an outstanding and consistent level of service to my client's customers.
The successful candidate will be confident communicating with customers, answering inbound calls and responding to queries in a timely and efficient manner. You will ensure that every communication is both a positive and professional experience.
This is a fast-paced environment with a hard-working, but fun and friendly team. You will play an integral part in building relationships with our customers and retaining customer loyalty by delivering an exceptional customer experience.
Answering the telephone and giving product quotations. Helping with the Reception phone when necessary.
Dealing with Couriers, Carriers and Area Sales Managers.
Strong IT skills and use of programs including Excel, Word and CRM systems.
Experience of export in a Customer Service environment will be an advantage.
If you have the skills required, along with a positive attitude and passion for helping, please apply now.


text:
DAY FOUR: HARA ITA NO MUSHI
("Stomachache Bug")
Written by Jonathan Wojcik, Researched and Translated by Rev Storm
This one might be the most straightforward and realistic of all the "belly bugs" as well as our very shortest entry for a while. It's quite simply a parasitic worm that causes stomach aches! It does so by biting with what the original text calls an "x-shaped mouth," though despite causing stomach aches, it's said to be yet another that inhabits the kidneys of its host. In fact, it seems like a majority of the bugs inhabit the kidneys. It's gonna get pretty crowded in there.
Design Review:
I really love the eerie, human eyes of this worm, and as with Gyoshu, the mouth is strikingly close to actual nematode anatomy, except for the fact that it is four-lobed rather than three-lobed. There are pretty much no other organisms who have that sort of "flower-shaped" mouth, and it's difficult to see even on the largest nematoda, so it's hard to guess at where our artist really got it from. The earliest known depictions of "microscopic" life in Japan wouldn't come until another couple centuries later!
TODAY'S REAL PARASITE: Trichuris trichiura
Like Ascaris, this is another parasitic nematode that grows fairly large (a couple of inches) and infects humans all around the world. Its presence is often asymptomatic and can go unnoticed for years at a time, but heavier infestations cause extreme abdominal pain and diarrhea. This is not a nematode with petaled lips, but it earns the common name "whipworm" for its much thinner anterior end, and this is what it threads in and out of the mucous membranes of the host's large intestine, absorbing the fluid secretions of our internal tissues. What we mean here is that these worms basically "stitch" their long, threadlike heads through the walls of your rectum, the rest of their fat body hanging loose. Penetrating the host tissues multiple times per worm to remain so embedded, some other symptoms of a particularly dense whipworm population can include internal bleeding, secondary bacterial infection, abnormal fluid accumulation (edema), various nutritive deficiencies and even "rectal prolapse with visible worms," just in case you ever thought you would sleep again.
In young children, infestation by whipworm is especially no joke; it can impair both physical and cognitive development for life, robbing kids living in poorer, less sanitary environments of countless future opportunities. This is a sad truth of many parasitic infections that many of us unfortunately think of only as some rare, exotic hazard. People like to think of parasites as something only "dirty" people contract, but it's not so easy when there's simply no clean drinking water, no basic health care, not even enough clean clothes to go around.

redpajama_set_name: RedPajamaCommonCrawl


Possibly the best DJ controller out there, but you'll want some extra gear to get the most out of it.
Flexible range of I/O. Massively intuitive control of Traktor's 'deep' features. Screens and touch- sensitive controls shift focus away from the laptop.
No jog wheels. Not really an 'all-in-one' device.
Back in 2013, Native Instruments MKII S2 and S4 Traktor controllers arrived they were met, perhaps unfairly, with a certain amount of disappointment. It was clear that NI had opted for refinements rather than reinvention. However, it transpires that NI wasn't throwing everything and the kitchen sink at their range because it had something newer, more feature-packed, and more ambitious in the works. Enter the Traktor Kontrol S8.
The S8 is Native Instruments' most expansive piece of DJ hardware to-date, both in terms of its features and its sheer size.
It's significantly larger than the S4 in both depth and width and, although it's actually more lightweight than it looks, it's not the sort of thing you could simply bring to a club without prior warning and hope there's room in the DJ booth.
Given that, even once you've made space for the S8 itself, you'll still need a laptop and possibly some additional gear (more on this later), we'd suggest that the space- conscious look elsewhere.
"Flipping between digital and analogue mode is as simple as pushing the Traktor Mode button at the top of each channel"
The S8 is clearly a quality piece of kit, however. It looks fantastic and feels very well built. The quality of pads and knobs will be familiar to anyone who has tried the S4 MKII or Maschine Studio, while the new replaceable fader section - which we're told uses a special inverted design to offer maximum durability - is the sort of properly 'pro level' touch that we'd expect at this price point.
With its backlit controls, LED-lined touchstrips and hi-res displays, the controller really looks the business in a darkened club environment and proves easy to navigate under all lighting conditions. Which is lucky, because the S8 really does have a lot going on.
The unit is centred around a four channel mixer that can control a quartet of software channels, act as a standalone analogue mixer, or any combination of these two options.
Flipping between digital and analogue mode is as simple as pushing the Traktor Mode button located at the top of each channel and, with built-in digital vinyl support and an impressive range of I/O (see In & Out), this makes the S8 a truly flexible modern DJ 'hub'.
Aside from the redesigned faders, the most notable feature of this mixer's channels is the addition of backlit on/off switches for each of the bi-directional filters; something which was a notable omission from earlier NI controllers.
To either side of the mixer is a pair of deck controllers. Along the bottom of each is the transport section, with Play, Cue, Shift, Sync, Deck select and a button for toggling Traktor's beat-locked Flux mode on and off.
Above this is a grid of eight pads, the functions of which can be changed via a strip of buttons along the outside edge. In Hotcue mode the pads are used to assign and jump between eight cue points, while Loop mode allows the user to create a loop and trigger beat jumps.
In Remix mode the pads trigger eight of the software's 64 available Remix Deck sample slots. Finally, Freeze mode adds a feature from NI's iOS app Traktor DJ, which instantly 'grabs' a loop from the current track, slices it into eight and allows each slice to be triggered as a one shot sample.
Above this sit four faders, which control the volume of the four Remix Deck slots, along with a large rotary that serves a number of purposes - it's primarily used for selecting and editing the size of loops, but also handles scrolling through the bank of Remix Deck samples, editing slices in Freeze mode and selecting a source for the loop recorder.
Above this is a row of rotaries that control the Remix Deck filters, effects sends and pitch, each with On/Off buttons. Finally, along the very top is a row of four effects rotaries, plus an FX Select button, offering control over the software's effects.
There is, however, a pair of very noticeable omissions from the S8's control set: jog wheels. We'll lay our cards on the table - when we first caught sight of the S8, this was something of a concern. We like jog wheels, or more accurately, we like to have something spherical that at least tries to replicate the feel of a turntable. This reviewier is no DMC champion, but he is the sort of semi-Luddite who will turn off sync when DJing with the S4.
It's not that Traktor's beat detection algorithms don't work - they're great, as are all the tempo sync'd performance features - but personally, this writer tends to get bored quickly if everything feels too 'on the rails'.
"The S8's intuitive control over Traktor's deeper features is absolutely unrivalled"
NI claims that the new touchstrips can be used in place of jog wheels and there's some truth in this. With a track stopped, these can be used to 'scratch' the current track, while holding down Shift puts them into Seek mode, allowing the user to jump to any part of the track.
With the track playing, these become Pitchbend controls, which - to be fair - are surprisingly well implemented and can be used for basic, 'nudge'-style beat-matching. The absence of pitch faders rules out any serious beat-matching though.
Tempo adjustments are all performed via a single central tempo rotary, which by default slowly fades between bpms and requires a Shift press to make quick adjustments.
Outside the realms of basic House and Techno, this is all too fiddly, and does seriously hamper the idea of the S8 as an 'all-in-one' controller if you want to mix with less 'rigid' genres like Funk or Soul.
Which brings us to probably the main point of this review: despite what NI says on the box, it's best not to think of the S8 as an 'all-in-one' device. The unit features built-in DVS support and comes with the full version of Traktor Scratch Pro, and connecting turntables or CDJs really brings the S8 to life.
With external gear handling the track control part of your set-up, it frees up the main body of the S8 to make the most of Traktor's advanced features. And in this area the controller is a serious joy to work with, thanks primarily to its best feature - the pair of screens.
While they're not particularly large, the implementation of these screens, coupled with the touch-sensitive controls, is absolutely fantastic. From library browsing to looping, sampling, tweaking the effects and beyond, they offer clear information exactly when it's needed. Suffice to say, they make it entirely possible to perform a set using Traktor, Remix Decks and all, without the need to look at a computer screen.
While it's lacking a little in the beat-matching department, the S8's intuitive control over Traktor's deeper features is absolutely unrivalled. Plugging a bit of extra 'analogue' gear into it transforms it from an interesting controller into a next-level hybrid DJ set-up.
In our tests we used a pair of turntables, plus a drum machine on a third input, sync'd via the MIDI out. In this state, the S8 is probably the best digital DJ device we've ever used. The ability to flip seamlessly between real and control vinyl, analogue and digital sources, live sampling and looping from the inputs, all easily and intuitively, is so much fun and inspires real creativity.
If you're after an all-in-one controller for casual use, the S2 or S4 may still be your best option, but if you're willing to commit to the whole space and wallet-sapping package, the S8 is the real deal.


(a) Determining the maximum capacity and distribution of existing resources allocated to health care.
(b) Identifying the demands for health care.
(c) Allowing health care policymakers to make informed choices.
(d) Evaluating the effectiveness of intervention programs in improving health outcomes.
(e) Comparing the costs and effectiveness of various treatment settings and approaches.
(f) Providing information to consumers and purchasers of health care.
(g) Improving the quality and affordability of health care and health care coverage.
(h) Assisting the authority in furthering the health policies expressed by the Legislative Assembly in ORS 442.025 (Findings and policy).
(i) Evaluating health disparities, including but not limited to disparities related to race and ethnicity.
(C) Establishing enrollment thresholds below which reporting will not be required.
(C) Data related to race, ethnicity and primary language collected in a manner consistent with established national standards.
(3) Any third party administrator that is not required to obtain a license under ORS 744.702 (Third party administrator license) and that is legally responsible for payment of a claim for a health care item or service provided to an Oregon resident may report to the authority the health care data described in subsection (2) of this section.
(4) The authority shall adopt rules establishing requirements for reporting entities to train providers on protocols for collecting race, ethnicity and primary language data in a culturally competent manner.
(5)(a) The authority shall use data collected under this section to provide information to consumers of health care to empower the consumers to make economically sound and medically appropriate decisions. The information must include, but not be limited to, the prices and quality of health care services.
(b) The authority shall, using only data collected under this section from reporting entities described in ORS 442.464 (Definitions for ORS 442.464 and 442.466) (1) to (3), post to its website health care price information including the median prices paid by the reporting entities to hospitals and hospital outpatient clinics for, at a minimum, the 50 most common inpatient procedures and the 100 most common outpatient procedures.
(C) Updated at least annually to reflect the most recent data available.
(d) The authority shall apply for and receive donations, gifts and grants from any public or private source to pay the cost of posting health care price information to its website in accordance with this subsection. Moneys received shall be deposited to the Oregon Health Authority Fund.
(e) The obligation of the authority to post health care price information to its website as required by this subsection is limited to the extent of any moneys specifically appropriated for that purpose or available from donations, gifts and grants from private or public sources.
(6) The authority may contract with a third party to collect and process the health care data reported under this section. The contract must prohibit the collection of Social Security numbers and must prohibit the disclosure or use of the data for any purpose other than those specifically authorized by the contract. The contract must require the third party to transmit all data collected and processed under the contract to the authority.
(d) Establish a time frame for the creation of the comprehensive health care information system.
(d) May not disclose trade secrets of reporting entities.
Note: See note under 442.464 (Definitions for ORS 442.464 and 442.466).
(g) Outline a five-year vision including implementation timelines in sufficient detail that health care stakeholders can plan for expected new data reporting requirements and uses.
(2) The Oregon Health Policy Board shall submit the plan developed under subsection (1) of this section to the interim committees of the Legislative Assembly related to health care no later than September 1, 2016.


September is National Yoga Month—a great reminder to practice yoga and create a more balanced lifestyle. While yoga can help improve flexibility, posture and balance, the practice of yoga offers so much more, including self-reflection, the practice of kindness to ourselves and others, and continued growth and self-awareness. Of course, all of this is much easier to move toward if you can find a sense of comfort in the poses.
Whether you are seated or standing, or have tight hips and shoulders, the following four poses are excellent examples of using a yoga block to enhance flexibility and find greater enjoyment in your yoga practice.
How: Kneel with your knees and feet hip-distance apart. Place the block between your shins on the medium-height level. Slowly shift your body back and sit on top of the block. Lengthen the spine, gently engage the core, and keep length in the back of the neck. Place palms on top of the thighs.
Why: Lifting the hips above the level of your knees reduces knee stress and discomfort, making it easier for you to sit in this position to reap the benefits of stretching the feet, ankles and thighs.
How: Position the yoga block 6-12 inches in front of the standing foot, slightly to the outside and on the highest height level. From a high-lunge position with the right foot forward, place your hand on the block and use the block to extend up and out of the shoulder while stepping into the right foot and straightening the right leg. Lift the left leg up parallel to the floor. Roll the left hip up and back and turn the whole torso so that the entire front of the body is facing the sidewall.
Why: The block shortens the distance between the hand and the supporting surface (in a sense, it lifts up the floor to meet your hand), making it easier to lift your torso, expand through the chest and keep your upper body in alignment without collapsing into the side body. When using the block to aid in balance, you'll be able to slowly open the hips and reap the benefits of strong ankles, knees, legs and mental focus.
How: You will need two blocks. Begin seated with your knees bent and feet on the floor. Gently let your knees fall open as the bottoms of the feet come together, and draw your heels toward your glutes. Place a block in the medium or low position underneath each thigh to support the weight of each leg. Lie down and place your arms at your sides.
Why: If the groin, inner thighs and hips are tight, you will feel a pulling sensation as the legs hang in space. The support of the blocks underneath the legs allows for the inner thighs and hips to release with ease.
How: You will need two blocks. Begin seated with your knees bent and feet on the floor. Position one block at medium height where you think your shoulder blades will rest when you lie back. Place the other block at medium height where you think your head will rest. Gently lean back and release your shoulder blades slightly above the first block. Then release your head onto the second block. Allow your arms to relax at your sides.
Why: Many of our daily activities tend to pull the arms and shoulders forward, but the yoga block helps us to expand the torso and ribcage. By opening the chest, shoulders, neck and abdominals, you will help create space that allows for deeper breathing.


Self Description: I'm a genuine and thoughtful person who's looking for the same. I'm a successful in work and always learning. I have a great sense of humor and think laughter is definitely the key to happiness. I'm very loyal and generous to my closest friends and family. I enjoy just hanging out with friends.
Comments: I would love to meet someone special to share my life with. Looking for someone with the same values as myself. Someone that loves spending time with me but also enjoys her independence and personal interests.


A protective finish coating put on the hardwood flooring to provide durability and scratch resistance. Aluminum oxide is the strongest and most resilient finish available for wood floors.
An engineered flooring product composed of a wood backing, a recycled high density wood fiber core, and a top layer with a locking mechanism designed into each plank which allows the flooring planks to snap and lock into one another without the use of an adhesive. These wood floors are designed for floating installations.
The process by which the grain of the alternating plies of the wood planks are glued and pressed at 90 degrees to each other. The result is the most dimensionally stable hardwood flooring product on the market.
Engineered flooring is composed of multiple layers or plies of real wood which are glued and pressed to one another with a pre-finished top layer which is available in a wide variety of different species. This design provides superior stability to a solid wood floor and makes the engineered product far less susceptible to issues of shrinking and expanding with changes in temperature and humidity.
Floating is the method of installation in which the hardwood flooring planks are installed over an acoustical underlayment with a moisture barrier. No adhesive is necessary when performing a floating installation using click lock engineered flooring. If using a tongue and groove product, it is required that the seams of the planks be glued together to keep them attached to one another.
The installation method in which glue is troweled out onto the subfloor and the hardwood flooring planks are set on top. The glue down method provides a permanent attachment and solid feel to the wood floor.
The process in which a series of grooves are carved throughout each plank to provide texture to the flooring. Random chiseling is added to give the flooring a rustic, antiqued look.
A style of distressing in which the planks have random chiseling divots punched out to give the hardwood flooring a naturally worn appearance.
The installation method in which the planks are nailed to a wood subfloor using either a manual or pneumatic nailer. The nails are driven through the tongue of the plank at a 45 degree angle into the subfloor.
Pre-finished floors have their stain and protective coating applied at the factory resulting in a stronger finish than that of a site-finished floor. Pre-finished floors are ready to install and require no additional staining or sealing, sparing you from the mess of dust from sanding and the fumes from chemicals.
The layer (ply) or layers (plies) of wood that are glued and pressed together in forming the engineered hardwood flooring product.
Quarter round is used to cover the expansion gap left between the hardwood floor and the wall. It is also used to cover the gap at he base of stair cases and toe kicks under cabinets.
Random length flooring is flooring that come in boxes or cartons made up of varying plank lengths. This gives the floor a natural look and prevents patterns during installation while efficiently maximizing all of the lumber used in milling.
Reducers are used to transition from the hardwood flooring to a floor of lower height such as , finished concrete, vinyl, or low-pile carpet.
The process of sanding the finish coating off of the existing floor and applying another coat of stain and another clear coat finish. If a natural look is desired then the clear coat finish is all that would be necessary.
SPC Flooring is an upgrade and improvement of regular luxury vinyl tiles (LVT), produced from natural limestone powder. SPC has 20 (yes, TWENTY) times as much impact resistant than base laminates and 10x impact resistance of WPC (wood composite core) flooring. Stone Polymer Composite flooring a.k.a. SPC Floors are also fire resistant, and completely waterproof.
Stair nose is used on the front edge of steps to transition from one floor level to the next to give the stairs a professional, finished look. Stair nose is placed on the front part of the step with the bullnose hanging over the front edge of the step.
The base of a structure on which the hardwood flooring will be installed. Subfloors are most commonly wood or concrete.
T-Molding is used to transition from a hardwood floor to another floor that is approximately the same thickness, such as tile. It can also be used as a transition in doorways connecting one room to another.
Threshold Reducers are most commonly used to transition from hardwood floors to high-pile carpet or tile with a thickness that is less than that of the wood. Threshold s can also be used to cover expansion gaps where quarter round can't be used such as sliding glass doors, around fireplaces, and entry doors.
Tongue and Groove hardwood flooring is milled with a tongue running down the length and width on one side of each plank with a groove running down the opposite length and width. When installed, the tongue slides snugly into the groove of the adjoining plank providing a tight fit with no gapping between the planks.
The pre-finished surface of the engineered hardwood flooring plank that is seen and walked on when the flooring is installed. The top layer is available in a wide variety of wood species as well as stain options.
A layer of acoustical foam, granulated rubber, or cork that is placed between the subfloor and the flooring product in order to provide sound absorbtion. Plastic sheeting is commonly attached to the bottom side of the underlayment to provide a moisture barrier between the hardwood flooring and the subfloor.


text:
El XXXIV Campeonato Mundial de Gimnasia Artística se celebró en Tianjin (China) entre el 8 y el 16 de octubre de 1999 bajo la organización de la Federación Internacional de Gimnasia (FIG) y la Asociación China de Gimnasia.

Se contó con la presencia de 553 gimnastas (293 hombres y 260 mujeres) de 73 países miembros de la FIG.

Resultados

Masculino

Femenino

Medallero

Enlaces externos
Resultados en la pág. web Sports 123 (en inglés).

1999
Tianjín
Gimnasia en 1999
Deporte en China en 1999
Gimnasia
Gimnasia en la República Popular China

redpajama_set_name: RedPajamaWikipedia


text:
Q: Pass integer to ViewModel when using HILT I am trying to figure out how to pass an integer from a fragment to a viewmodel while using hilt. I have ready that viewmodel factories can be used for this, I am not sure how this would be done using DI.
In the code below, I am trying to figure out how I can pass albumId to the viewModel. The albumId will be used when fetching data from an API endpoint.
Fragment
override fun onCreateView(
    inflater: LayoutInflater, container: ViewGroup?,
    savedInstanceState: Bundle?
): View? {
    // Inflate the layout for this fragment
    val view = inflater.inflate(R.layout.fragment_album_details, container, false)

    val albumId = arguments?.getInt("album_id")

    viewModel.songs.observe(viewLifecycleOwner) {
        view.song_recyclerview.apply {
            layoutManager = LinearLayoutManager(this.context)
            adapter = SongAdapter(viewModel.songs)
        }
    }
    return view
}

ViewModel
class SongViewModel @ViewModelInject constructor(
    songRepo: SongRepository,
    @Assisted savedStateHandle: SavedStateHandle
) : ViewModel(), LifecycleObserver {

    val songs: LiveData<List<Song>> = songRepo.getSongs(1)
}

Repository
class SongRepository constructor(
    private val musicService: MusicService
)
{
    fun getSongs(album_id: Int): LiveData<List<Song>> {
        val data = MutableLiveData<List<Song>>()
        musicService.getAlbumTracks(album_id).enqueue(object : Callback<List<Song>> {
            override fun onResponse(call: Call<List<Song>>, response: Response<List<Song>>) {
                data.value = response.body()
            }

            override fun onFailure(call: Call<List<Song>>, t: Throwable) {
            }
        })
        return data
    }
}

A: I was finally able to figure out a solution to the problem. I added a field to the viewmodel, and a method to set a value for that field. Basically, I call viewModel.start(int) then call viewModel.songs.
ViewModel
class SongViewModel @ViewModelInject constructor(
    songRepo: SongRepository,
    @Assisted savedStateHandle: SavedStateHandle
) : ViewModel(), LifecycleObserver {

    private val _id = MutableLiveData<Int>() // int field
    private val _songs = _id.switchMap { id ->
        songRepo.getSongs(id)
    }
    val songs: LiveData<List<Song>> = _songs
    fun start(id: Int) { // method to update field
        _id.value = id
    }
}

Fragment
override fun onViewCreated(view: View, savedInstanceState: Bundle?) {
    super.onViewCreated(view, savedInstanceState)

    // get data from bundle and pass to start()
    arguments?.getInt(("album_id"))?.let { viewModel.start(it)}

    viewModel.songs.observe(viewLifecycleOwner) {
        view.song_recyclerview.apply {
            layoutManager = LinearLayoutManager(this.context)
            adapter = SongAdapter(viewModel.songs)
        }
    }
}

redpajama_set_name: RedPajamaStackExchange


30 minutes from the city of Tarapoto and 40 minutes from the airport. It should take the road to the city of San Antonio and take the road to the left (road Aucaloma) for approximately 2 km.
City of Tarapoto is a market town of rapid urban growth and unplanned rural population is engaged in the cultivation of coffee, cacao and rice. Know your craft, festivals, fine dining, traditional food like juanes, tacachos with jerky, soda cocona, grapes and exotic liquors.


text:
Q: load effect file for directx shader with 3ds max sdk I am creating a utility plugin for 3ds max using 3ds max SDK in C++. In my plugin, I need to assign directx shader material to some of the selected nodes in the scene. I use the following code to create a directx shader material:
Mtl* mtl = (Mtl*)(ip->CreateInstance(MATERIAL_CLASS_ID, kDxMaterialClassID));
IDxMaterial3* dxMtl = (IDxMaterial3*)mtl->GetInterface(IDXMATERIAL3_INTERFACE);

The created material use the default shader effect file, in my case, it is %MAXDIR%\maps\fx\default.fx. But how can I load other effect file to this material?
I searched the 3ds max SDK documentation. The IDxMaterial3 class provide a function: GetCurrentParser which returns an effect parser interface (class IEffectParser). The IEffectParser provides a function LoadEffect which seems to be the correct function to load an effect file.
virtual bool LoadEffect (
    LPVOID pDevice,     //The DirectX device
    IEffectManager* em, //A pointer to the IEffectManager instance
    const MCHAR* effect,//A string containing the effect - this can either be a filename or a buffer contaning the effect
    bool  fileType,     //Defines whether the string contains a file name or a buffer
    bool  forceReload   //If true don't pull the effect from a cache, you need to reload from disk
)

However, the second parameter of the function is an IEffectManager* type. I have no idea what it is and how should I get one from the material.
Am I looking at the right direction ? If not, what is the right way to load an effect file for the directx shader material ?

A: I have found a way to set the effect file path by using the paramete blocks of the material. I post my solution in case anyone else encounter the same problem:
// parameter block index of the effect file
const int kEffectFilePBlockIndex = 1;

// parameter ID of the effect file option
const int kEffectFileParamID = 0;

bool SimpleShaderAdaptor::apply_shader(INode* node) {

    // create the shader material
    Mtl* mtl = (Mtl*)(ip_->CreateInstance(MATERIAL_CLASS_ID, kDxMaterialClassID));
    if( !mtl ) return false;

    // get the material interface
    IDxMaterial3* dxmtl = (IDxMaterial3*)mtl->GetInterface(IDXMATERIAL3_INTERFACE);
    if( !dxmtl ) return false;

    // set the effect file path
    IParamBlock2* pb = mtl->GetParamBlock(kEffectFilePBlockIndex);
    BOOL ret = pb->SetValue(kEffectFileParamID,
                            ip_->GetTime(),
                            fx_filepath_.c_str()); // The Effect file path to be set
    if( ret == FALSE ) return false;

    node->SetMtl(mtl);
    return true;
}

the effect file parameter of the directx shader material is in the 1st parameter block with ParamID = 0. By setting the value of that parameter, you can load the specifit effect file.


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The 120 room, luxury resort is situated on a cliff overlooking the Indian Ocean in Mangapwani and offers panoramic views from the lounge, restaurant, bar and recreational areas. Both infinity swimming pools have wonderful views of the ocean. There is also a jetty bar that offers the perfect place from which to enjoy a sundowner, or you could sail on our dhow and watch the beautiful sunsets that the West coast of Zanzibar is famous for. 96 of our rooms offer views from the bedrooms and private balconies, with all the modern facilities that you expect from an international hotel, with complimentary Wi-Fi throughout the property.
The resort offers a number of activities for the energetic, including a fully equipped gym, two tennis courts, a volleyball court, a squash court and bicycles for rides through the coconut plantation. There is also a water sports centre offering a wide range of activities including water skiing, sailing and more. All non-motorized water sports are free to hotel guests.
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text:
Q: Web API 2.2 Content Negotiation with file extensions I am working on a Web API and I want to use Content Negotiation with file extensions to allow browser clients to specify the content they want to receive.  For instance
http://localhost:54147/data.xslx.

According to  this article (http://msdn.microsoft.com/en-us/magazine/dn574797.aspx) I should be able to setup routing  with something like this
//setup default routes
config.Routes.MapHttpRoute(
    name: "Default",
    routeTemplate: "{controller}/{id}",
    defaults: new {id = RouteParameter.Optional}
);

//setup routes with extensions
   config.Routes.MapHttpRoute(
        name: "Url extension",
        routeTemplate: "{controller}/{action}.{ext}/{id}",
        defaults: new { id = RouteParameter.Optional }
   );
Here is my simple controller
public class TestController : ApiController
{
    public HttpResponseMessage Get()
    {
        var items = new[] {"test1", "test2", "test3"};
        return Request.CreateResponse(HttpStatusCode.OK, items);
    }
}

using this url
http://localhost:54147/test/get.xlsx

I always get the browser default (xml in chrome, json in IE11).
or possibly
http://localhost:54147/test.xlsx

to which I get the error
No HTTP resource was found that matches the request URI 'http://localhost:54147/test.xlsx'.

I should be able to use my custom formatter.  But it's not happening.  Here is the constructor of my custom formatter.
public ExcelFormatter()
{
    MediaTypeMappings.Add(new UriPathExtensionMapping("xlsx", ContentType.Excel));
    SupportedMediaTypes.Add(new MediaTypeHeaderValue(ContentType.Excel));
}

Again according to the article this should help the API Content Negotiator use my custom formatter.  I appreciate any help.

A: As the question is old, but is still without an answer:
Generally this links should help:

*

*How to build media formatter

*Microsofts words about content negotiation

To the code in the question:

*

*it seems you need to extend from BufferedMediaTypeFormatter(sync) or MediaTypeFormatter`(async)

*you need to make your formatter known to HttpConfiguration.Formatters (link)

You probably want to do this in an config for the complete application.
For testing you could add in to a single ApiController like following.
untested example
public class TestController : ApiController
{
    TestController() {
      Configuration.Formatters.Add(new ExcelFormatter());
    }

    public HttpResponseMessage Get()
    {
        var items = new[] {"test1", "test2", "test3"};
        return Request.CreateResponse(HttpStatusCode.OK, items);
    }
}
```


text:
Supplementary Materials935ReagentTable. that ovarian gene amplification and embryonic cleavage are two
Supplementary Materials935ReagentTable. that ovarian gene amplification and embryonic cleavage are two time periods in development that are particularly sensitive to moderate deficits in DNA replication function. This last observation has broader relevance for interpreting why moderate mutations in the human ortholog of and other DNA replication genes cause tissue-specific malformations of microcephalic dwarfisms. 1994; Parker 2017; Tocilj 2017; Yuan 2017; Zhai 2017). Upon initiation, a big replisome complicated of protein assembles at replication forks, which in turn migrate bidirectionally outward from the foundation to synthesize brand-new DNA strands (Pellegrini and Costa 2016). Reassembly of brand-new pre-RCs is normally inhibited until following the following mitosis after that, making certain each genomic area is duplicated only one time per cell department (Hillsides and Diffley 2014). Issues with these techniques of DNA replication could cause replication DNA and tension harm, which is normally sensed and corrected by cell routine checkpoints (Hillsides and Diffley 2014). Nevertheless, high degrees of replication tension and checkpoint failing are main contributors to genome instability and cancers (Hillsides and Diffley 2014; Zeman and Cimprich 2014). Furthermore, hypomorphic mutations in several individual genes that encode pre-RC and various other replication proteins will be the genetic reason behind a course of developmental malformations referred to as microcephalic primordial dwarfisms (MPDs) TMP 269 inhibition (Klingseisen and Jackson 2011; Khetarpal 2016). While very much has been discovered, it really is still not really fully understood the way the DNA replication plan is normally coordinated with advancement and perturbed in disease. An severe exemplory case of developmental adjustment towards the DNA replication plan takes place during early embryogenesis. Embryogenesis starts with department of nuclei within a common syncytium, as well as the initial nine of the nuclear cleavage divisions contain just S and M p2004). The duration of the initial nine S/M cycles are speedy, 8?min, where genomic DNA is replicated in less than 3?min by initiating replication from numerous, closely spaced roots (10?kb apart) Rabbit Polyclonal to DLGP1 (Blumenthal 1974; Sasaki 1999). As the most zygotic transcription will not start until later through the mid-blastula changeover (MBT), the first nuclear cleavage divisions are totally reliant on maternally encoded protein (Edgar and OFarrell 1989). Very much remains unknown, nevertheless, about the legislation from the initial nine S/M cycles, and exactly how comprehensive genome duplication specifically once per routine is ensured. These early cycles absence a DNA DNA or replication harm checkpoint, although they perform TMP 269 inhibition have got a spindle set up checkpoint (SAC) that displays microtubule-kinetochore accessories (Raff and Glover 1988; Glover and Girdham 1991; Fogarty 1997; Sibon 1997, 1999, 2000; Takada 2003, 2007, 2015; TMP 269 inhibition Perez-Mongiovi 2005; Crest 2007; Oliveira 2010). As the early, speedy S/M cycles could be an edge by shortening developmental period, they also increase the risk of propagating DNA mutation into multiple cells that are descended from these early founder nuclei (OFarrell 2004). Another intense example of developmental changes to the DNA replication system happens during oogenesis when genes required for eggshell (chorion) synthesis are selectively amplified in DNA copy quantity (Spradling 1981). This developmental gene amplification happens through DNA rereplication from amplicon origins at six loci in somatic follicle cells of the ovary (Claycomb and Orr-Weaver 2005; Calvi 2006; Nordman TMP 269 inhibition and Orr-Weaver 2012). Much like other origins, amplicon origins are bound from the pre-RC and triggered by cell cycle kinases, and have been used like a model system to uncover conserved DNA replication mechanisms (Calvi 1998; Asano and Wharton 1999; Royzman 1999; Loebel 2000; Aggarwal and Calvi 2004; Zhang and Tower 2004; Nordman 2011; Alexander 2016). TMP 269 inhibition Among additional methodological advantages, gene amplification can.
Supplementary MaterialsS1 Data: Dining tables A-J. between low BMI and improved
Supplementary MaterialsS1 Data: Dining tables A-J. between low BMI and improved degrees of T helper (Th) 1 (Interferon (IFN)-, (interleukin (IL)-2, IL-12), Th2 (IL-4, IL-5, IL-13), aswell as IL-10, Tumor and IL-33 necrosis element-, however, not IL-8 or C reactive proteins. The actions of arginase, an enzyme connected with immunosuppression, had been identical in plasma, peripheral bloodstream mononuclear cells (PBMC) and neutrophils from all organizations and no variations in the manifestation levels of Compact disc3, a marker of T cell activation, had been seen in Compact disc8+T and Compact disc4+ cells. Furthermore, whereas isoquercitrin enzyme inhibitor the capability of neutrophils through the malnourished organizations to phagocytose contaminants was not impaired, their capacity to produce reactive oxygen species was impaired. Finally we evaluated the frequency UDG2 of a subpopulation of low-density neutrophils and show that they are significantly increased in the malnourished individuals. These differences were more pronounced in the severely malnourished group. In summary, our results show that even in the absence of apparent infections, healthy malnourished individuals display dysfunctional immune responses that might contribute to increased susceptibility and severity to infectious diseases. Introduction Undernutrition, here referred to as malnutrition, is a result of inadequate diet and/or malabsorption of nutrients. An estimated one out of ten people in the world are malnourished, of those 95.9% are living in the developing world [1]. Protein energy isoquercitrin enzyme inhibitor malnutrition (PEM) has been associated with different infectious diseases including malaria, tuberculosis, lower respiratory tract infections and diarrheal diseases; and they are the main reason behind mortality and morbidity in developing countries [2, 3][4, 5]. Malnutrition can be regarded as among the significant reasons of immunodeficiency: in malnourished individuals, both obtained and innate immunity are affected [6, 7]. Common immune system problems are an imbalance in the percentage of Compact disc4/Compact disc8+ T cells [8], low manifestation levels of Compact disc69 on lymphocytes [9], isoquercitrin enzyme inhibitor biased T helper cell reactions [10, 11], decreased antibody reactions [8]; impaired phagocytosis by macrophages [12, 13], lower nitrite/nitrate concentrations in wound liquid [14] and reduced NF-kappaB activation by macrophages [15] are also demonstrated in experimental types of PEM. Furthermore, it's been demonstrated that malnutrition and the next impaired immune reactions reduce the effectiveness of dental vaccines in developing countries [16]. Even though it really is generally approved that malnutrition takes on an essential role in improved susceptibility to disease and/or disease intensity by weakening the disease fighting capability, the causal links between infections and malnutrition aren't yet more developed. Since infection may also trigger malnutrition through many factors such as for example decreased hunger and improved catabolism [17], it really is difficult to recognize the contribution of pre-existing malnutrition and/or infection-induced malnutrition to improved disease intensity [18, 19]. Significantly, a lot of the focus on malnutrition continues to be finished with malnourished individuals experiencing infectious illnesses primarily, or additional pathological circumstances, and, aside from research on individuals with consuming disorders such as for example anorexia nervosa [20, 21], small is well known about the effect on malnutrition for the disease fighting capability of "evidently healthful" adult people. Our previous function studying the immune system responses of individuals with visceral leishmaniasis (VL), a fatal infectious disease due to parasites possibly, has shown that most these patients suffer from severe malnutrition [22, 23]. The immune status of these patients is characterised by a profound suppression of T cell responses, high levels of cytokine and chemokine production and strong isoquercitrin enzyme inhibitor inflammatory responses (reviewed in [24, 25]. These patients are living in the North West of Ethiopia, where malnutrition appears to be relatively common [26], however, precise information about adult malnutrition is scarce in Ethiopia. Here, we performed a prospective study with "apparently healthy" individuals with normal and low BMI, living in the North West isoquercitrin enzyme inhibitor of Ethiopia. Our aim was to compare, in malnourished individuals and individuals with normal BMI, several immunological parameters that have been shown to.
Supplementary Materials Supplementary Material supp_141_2_389__index. can be both induced by dorsally
Supplementary Materials Supplementary Material supp_141_2_389__index. can be both induced by dorsally produced TGF indicators (Alder et al., 1999; Lee et al., 2000) and positively maintained from the roofing dish organiser (Broom et al., 2012). Although can be transient (in every but specialised granule cell precursors from the cerebellum) this manifestation is sufficient to conditionally drive reporters that have been used to map all rhombic lip derivatives in transgenic mice (Machold and Fishell, 2005; Wang et al., 2005; Rose et al., 2009) and fish (Kani et al., 2010). Increasing resolution in these fate maps has revealed that, for the cerebellar rhombic lip of rhombomere (r) 1, there is a perhaps surprising diversity of neuronal derivatives from the pool born within a very narrow temporal window, before the generation of cerebellar cell types. In particular, fate maps identify small groups of isthmic nuclei such as the cholinergic parabigeminal nucleus and the dorsal nucleus of the lateral lemniscus that lie outside the cerebellum and at the border of the midbrain Alas2 (Machold and Fishell, 2005; Rose et al., 2009). These isthmic nuclei play important roles in regulating bilateral correlation of midbrain sensory maps for both vision and audition, respectively (Butler and Hodos, 1996). Isthmic nuclei with divergent anatomical conformations show a fragmented distribution of isthmic nuclear structures across vertebrate phyla. This includes specialised cell groups such as the isthmo-optic nucleus that projects towards the retina in parrots, some basal seafood and a subset of reptiles (Butler and Hodos, 1996). This general variability shows different developmental constraints on isthmic rhombic lip derivatives in comparison to additional, conserved outputs from the pool in the cerebellum. What exactly are the likely applicants for regulating the variety of the different derivatives? An initial determinant of cell fate in the rhombic lip may be the temporal patterning cues (Gilthorpe et al., 2002; Machold and Fishell, 2005) through extrinsic indicators that are however to be established (Wilson and Wingate, 2006). Nevertheless, a highly varied group of nuclei in ventral r1 can be stated in a very brief temporal window, and for that reason a temporal sign is not apt to be adequate to create such good grain specificity in various cell types. A feasible additional way to obtain patterning information can be spatial cues, which may be split into dorsalising indicators from the roofing dish boundary organiser (Broom et al., 2012) and rostrocaudal cues from the midbrain/hindbrain isthmus. As the linear pool of manifestation and its own derivatives in r1, we've contrasted mouse transgenic manipulation of FGF signalling with tests in the chick embryo model. The second option can be amenable to a variety of techniques, including an impartial assessment from the relationships between different cells through ablation research in tradition and focal focusing on of hereditary manipulations by electroporation. Through these, we display that the TRV130 HCl inhibition site can be cryptically organised into two territories that are individually taken care of by FGF and roofing plate indicators. These particular isthmic and rhombic lip domains provides rise to different derivatives: the previous providing rise TRV130 HCl inhibition to isthmic nuclei. We suggest that this pool of isthmic, FGF-dependent progenitors may be a conserved feature of r1 patterning, recommending a re-evaluation of hereditary fate maps and a re-definition of rhombic lip by its inductive interactions instead of gene appearance alone. RESULTS is TRV130 HCl inhibition certainly portrayed in three specific domains in r1 in chick and mouse In evaluating the appearance of in the chick embryo at embryonic time (E) 5, we determined a prominent site of appearance in dorsal, isthmic r1 specific through the rhombic lip evidently, before the development of an exterior granule level (EGL) (Fig. 1A). This isthmic TRV130 HCl inhibition area extends through the pial to ventricular surface area of the tissues (Fig. 1B) and it is bordered rostrally by area becomes segregated through the developing cerebellum right TRV130 HCl inhibition into a area that is situated rostral towards the cerebellar plates (Fig. 1E). Evaluation of mouse embryos at an comparable stage (E14.5) reveals an identical, although markedly smaller sized area of appearance abutting the isthmus (Fig. 1F). By E8 in chick, the rostral area of appearance is certainly downregulated and it is solely expressed in a definite EGL (data not really shown). Open up in another home window Fig. 1. Distinct Atoh1 domains in r1. (A) Within a dorsal watch from the cerebellum at E5, appearance sometimes appears in a definite rostral/isthmic area (reddish colored arrow) with the cerebellar rhombic lip. (B-D) Coronal (B) and sagittal (C,D) areas at E5 (discover schematic, top still left) reveal appearance in the isthmic area reaches the ventricular surface area (B, arrow).
Supplementary MaterialsSupplementary desks and figures. signalling pathways regulating the pluripotency of
Supplementary MaterialsSupplementary desks and figures. signalling pathways regulating the pluripotency of stem cells, the AMPK signalling pathway, the HIF-1 signalling pathway, the PI3K-Akt signalling pathway, the Wnt signalling pathway as well as the Hippo signalling pathway, had been screened. Third, VEGFA and PHLPP2 were defined as hub genes in the PPI network. Last, we discovered that hsa-miR-34a-5p inhibits BSG cell invasion not really Cbll1 do; overall success;KPSkarnofsky performance scale; pilocytic astrocytoma; astrocytoma; oligodendroid astrocytoma; anaplastic astrocytoma; glioblastoma multiforme; vincristine; carboplatin; concurrent chemoradiotherapy; temozolomide; Irinotecan; designed cell death proteins 1. Survival evaluation showed which the median Operating-system was 13.2 months. Even more NSC 23766 enzyme inhibitor particularly, the median success was 20.three months in sufferers with low-grade BSGs and 10.1 months in sufferers with high-grade BSGs. At the proper period of the evaluation, 17 from the 25 situations (68%) had passed away. Among those that died, 15 acquired high-grade BSGs and 2 acquired low-grade BSGs. Twenty-eight useful DE-miRNAs and 2546 focus on genes had been identified The full total DE-miRNAs had been selected predicated on the testing process (Amount ?(Figure1A).1A). Based on the results of the Kaplan-Meier survival curves, 28 practical DE-miRNAs, which included 13 upregulated and 15 NSC 23766 enzyme inhibitor downregulated miRNAs in high-grade BSGs compared with the corresponding levels in low-grade BSGs, were selected (Number ?(Number1B,1B, 2 and S1, Table ?Table22 and ?and3).3). Based on the FC, hsa-miR-1290, hsa-miR-130b-3p and hsa-miR-18a-3p were the top three most upregulated miRNAs and hsa-miR-31-5p, hsa-miR-34a-3p and hsa-miR-34a-5p were the top three most downregulated miRNAs. miRWalk2.0 was used to predict the prospective genes of the functional DE-miRNAs and generated 2546 potential target genes, including 1179 genes that were potential focuses on of the upregulated miRNAs and 1367 genes that were potential focuses NSC 23766 enzyme inhibitor on of the downregulated miRNAs. Open in a separate window Number 1 Summary of microarray results of miRNA manifestation in BSGs. (A) Volcano plots of the distributions of miRNAs. (B) Cluster analysis of practical DE-miRNAs in 25 instances of BSG, data are offered as a warmth map ( 0.05). Table 2 Functional DE-miRNAs upregulated in high grade BSGs compared with low grade. protein-protein connection As demonstrated in Figure ?Number4,4, a regulatory network of the top hub genes was constructed. PPI analysis showed the NSC 23766 enzyme inhibitor network of hub genes for the upregulated practical miRNAs consisted NSC 23766 enzyme inhibitor of 38 edges, and the network of hub genes for the downregulated practical miRNAs consisted of 45 edges. Open in a separate window Number 4 Gene regulatory network based on the top 15 hub target genes of the practical DE-miRNAs. Orange represents the prospective genes of the upregulated miRNAs and blue represents the prospective genes of the downregulated miRNAs. (A) Upregulated miRNAs. (B) Downregulated miRNAs. Validated grade-associated practical DE-miRNAs and hub genes in BSG samples We extracted RNA from 29 BSG cells, including 17 high-grade BSGs and 12 low-grade BSGs, to validate the grade-associated miRNAs and hub genes acquired from the bioinformatics analysis. Total RNA was extracted from your cells, and q-PCR was carried out to detect miRNA. Six of the 28 functional DE-miRNAs (hsa-miR-130b-3p, hsa-miR-19a-3p, hsa-miR-20a-5p, hsa-miR-106a-5p, hsa-miR-34a-5p and hsa-miR-195-5p) were proven to be grade-associated functional DE-miRNAs (Figure ?(Figure5A-F5A-F and Table S2). Next, using q-PCR assays, we determined the expression of the top 8 hub genes according to degrees in all the BSG tissue RNA samples. We found that 3 of 8 hub genes, APP, PHLPP2 and VEGFA, were proven to be differentially expressed between low- and high-grade BSGs (Figure ?(Figure5G-I).5G-I). Finally, we detected in BSG tissues the expression of mir-7, mir-21 and mir-451, which have been shown to be differentially expressed between low- and high-grade supratentorial gliomas. We.
Background Environmentally driven immune activation was suggested to contribute to high
Background Environmentally driven immune activation was suggested to contribute to high rates of HIV-1 infection in Africa. in the supernatants of PHA-activated PBMC, were higher in the EUs than in the UCs (p = 0.007). Conclusion We found low levels of CD4 T cell activation and reduced PBMC susceptibility to HIV-1 contamination in Central African EUs, indicating that both may contribute to the resistance to HIV-1 contamination. Background Central African Republic (CAR) has a high prevalence rate of HIV-1 contamination estimated at 18% among pregnant women [1]. The primary route of transmission is heterosexual. P7C3-A20 enzyme inhibitor High rates of contamination in HIV-1-infected individuals in Africa have been suggested to be related to immune hyperactivation driven by environmental factors, including high exposure to infectious agencies and poor hygienic circumstances [2]. Certainly, higher degrees of Compact disc4 and Compact disc8 T cell activation have already been reported in HIV-1 contaminated Africans in comparison to Western european populations [3]. Specifically, HLA-DR appearance on Compact disc4 T cells was correlated with Compact disc4 T cell count number, viral insert and coinfections [4]. Effective antiretroviral therapy was reported to diminish the known degrees of T cell activation markers, with a more powerful effect on Compact disc8 than on Compact disc4 T cell activation [4,5]. A pattern of immune system activation, including a rise of turned on T cell subsets and of the HIV-1 CCR5 co-receptor appearance, continues to be reported not merely in HIV-infected however in HIV-uninfected African populations [6-9] also. Interestingly, peripheral bloodstream mononuclear cells (PBMC) from people with a chronic immune system activation exhibited higher susceptibility to HIV-1 infections in vitro [10]. Regardless of the dispersing of HIV-epidemic in CAR, a regular percentage of Central Africans who've been persistently P7C3-A20 enzyme inhibitor open for several years to contamination through unprotected sexual associations TMEM47 with HIV-1 infected partners remained seronegative (Bgaud E. et al., unpublished data). P7C3-A20 enzyme inhibitor Most studies on correlates of protection against HIV-1 contamination in seronegative uncovered individuals in other African countries were conducted on cohorts of commercial sex workers (CSW) whereas only a few studies concerned seronegative partners in serodiscordants couples [11-18]. In these studies, HIV-1-specific helper and cytotoxic T cell responses have been detected in a significant proportion of uncovered seronegative individuals [19-23]. HIV-1-specific mucosal IgA were also detected in persistently unfavorable Kenyan CSW and were shown to be capable of in vitro P7C3-A20 enzyme inhibitor neutralization of HIV-1 [24,25]. The question of whether these specific immune responses exert a protective role or they reflect exposure to HIV-1 is, however, still debated [26-28]. Other immunological or genetic factors potentially related to the resistance have also been addressed in uncovered seronegative African individuals but no obvious protective mechanisms emerged from these studies [12,13,29-31]. Genetic polymorphism in the CCR5 gene, such as the CCR5-32 mutation, which was associated to the resistance to HIV-1 contamination in Caucasian populations, has not been found in Africans [32]. We analyzed a group of uncovered seronegative partners of HIV-1 infected individuals in Bangui with a long history of leading a common life and practicing unprotected sexual relations. Considering the background of immune activation reported in African populations, we asked whether differences in the levels of CD4 T cell activation and in the capability to reproduce HIV-1 in vitro could possibly be linked to the obvious level of resistance to an infection within this group. In the research conducted, we present lower degrees of Compact disc4 T cell activation and low in vitro susceptibility to HIV-1 an infection in shown seronegative people than in low-risk Central African bloodstream donors. Outcomes Features of research people Forty-five European union companions of HIV-1 infected people were contained in the scholarly research. Median common lifestyle with unsafe sex relationships was estimated to become 8 years (Desk ?(Desk1).1). During enrollment, most HIV-1 infected partners were consulting for medical symptoms related to HIV-1 illness. Median CD4 T cell count of HIV-1 infected partners was 73 cells/l (IQR: 26-227) and median plasma viral weight was 7.2 104 copies/ml (IQR: 1.3 104 C 14.8 104). Completely, the medical and virological characteristics of HIV-1 infected individuals suggested a long-term illness and a history of high risk exposure for his or her partners. There were no significant variations in potential risk factors for illness between the serodiscordant couples and 243 couples consulting in the Communitarian Hospital of Bangui in which both partners were seropositive (not.


There are couple of advantages of using steam cleaning technology for different cleaning tasks. When it comes to tenancy cleaning, here included living rooms,eating places and other rooms around the rental unit, it is very important no traces to be left behind. The steam cleaning tools eliminate everything chemical and toxic with the power of the dry vapour steam. Of course the steam cleaning units are great, but there is a time when their power isn't enough.
The thing is that the steam cleaning units only melt and dissolve the trash. It is up to the user of the tools to pick up the rest of the melted deposit, which could be an inconvenience and, of course, it costs time. And if you want the job done before the last day of your contract, you should think of something else.
Steam vacuum cleaners are something, that may come in handy during the process of cleaning work. When it comes to some though areas or places, those are the best helpers. For example removing bugs form the bed. They not only terminates the bugs using the power of steam, but also with the help of the vacuum pick them up afterwards. This is really helpful when it comes to thick bedding and cushions. The steam cleaning tools are also very useful for removing and destroying the eggs and larva of the bugs.
And not only that. Some of the best steam cleaning machines not only melt and clean but the also sanitize the already cleaned surface. That is perfect when it comes to bed mattresses or surfaces in the kitchen or basically everywhere that has to be perfectly clean.
Of course not everybody who lives in a rental property has such tools. Therefore you could either do all that cleaning with the help of whatever you got, or you could look for professional end of tenancy cleaning services, offered in your area.


text:
package money

import (
	"database/sql"
	"database/sql/driver"
	"encoding"
	"encoding/json"
	"encoding/xml"
	"errors"
	"fmt"
)

// Money2 表示金钱, 单位为分.
//
// Money2 是 Money 的扩展, 支持数据库 decimal(x.2) 类型的直接存取.
type Money2 int64

var (
	_ encoding.TextMarshaler   = Money2(0)
	_ encoding.TextUnmarshaler = (*Money2)(nil)
)

var (
	_ json.Marshaler   = Money2(0)
	_ json.Unmarshaler = (*Money2)(nil)
)

var (
	_ xml.Marshaler   = Money2(0)
	_ xml.Unmarshaler = (*Money2)(nil)
)

var (
	_ driver.Valuer = Money2(0)
	_ sql.Scanner   = (*Money2)(nil)
)

// Value 实现了 driver.Valuer 接口, 将 Money2 编码成 decimal(.2) 格式.
func (m Money2) Value() (driver.Value, error) {
	return m.MarshalText()
}

// Scan 实现了 sql.Scanner 接口, 将 decimal(.2) 字段解码到 Money2 中.
func (m *Money2) Scan(value interface{}) error {
	switch v := value.(type) {
	case []byte:
		return m.UnmarshalText(v)
	case string:
		return m.UnmarshalText([]byte(v))
	case nil:
		return errors.New("unsupported Scan, storing nil driver.Value into type Money2")
	default:
		return fmt.Errorf("unsupported Scan, storing driver.Value type %T into type Money2", value)
	}
}

// Text 将 Money2 编码成 xxxx.yz 这样以 '元' 为单位的字符串.
func (m Money2) Text() string {
	return Money(m).Text()
}

// MarshalText 将 Money2 编码成 xxxx.yz 这样以 '元' 为单位的字符串.
func (m Money2) MarshalText() (text []byte, err error) {
	return Money(m).MarshalText()
}

// MarshalJSON 将 Money2 编码成 "xxxx.yz" 这样以 '元' 为单位的字符串.
func (m Money2) MarshalJSON() ([]byte, error) {
	return Money(m).MarshalJSON()
}

// MarshalXML 将 Money2 编码成 xxxx.yz 这样以 '元' 为单位的字符串.
func (m Money2) MarshalXML(e *xml.Encoder, start xml.StartElement) (err error) {
	return Money(m).MarshalXML(e, start)
}

// UnmarshalText 将 xxxx.yz 这样以 '元' 为单位的字符串解码到 Money2 中.
func (m *Money2) UnmarshalText(text []byte) (err error) {
	return ((*Money)(m)).UnmarshalText(text)
}

// UnmarshalTextString 将 xxxx.yz 这样以 '元' 为单位的字符串解码到 Money2 中.
func (m *Money2) UnmarshalTextString(text string) (err error) {
	return ((*Money)(m)).UnmarshalTextString(text)
}

// UnmarshalJSON 将 "xxxx.yz" 这样以 '元' 为单位的字符串解码到 Money2 中.
func (m *Money2) UnmarshalJSON(data []byte) (err error) {
	return ((*Money)(m)).UnmarshalJSON(data)
}

// UnmarshalXML 将 xxxx.yz 这样以 '元' 为单位的字符串解码到 Money2 中.
func (m *Money2) UnmarshalXML(d *xml.Decoder, start xml.StartElement) (err error) {
	return ((*Money)(m)).UnmarshalXML(d, start)
}

redpajama_set_name: RedPajamaGithub


text:
Sunday Express teases readers with fact-based article for April Fools
Readers of the popular tabloid took to social media to try and ascertain which 1st of April story was a well-researched piece of unbiased reporting hidden among the usual fare of rabble-rousing drivel written by creepy alcoholics.
Simon Williams, a red-faced harrumpher and Express subscriber, said that trying to find actual journalism in the tabloid's page was a cherished tradition among his peers but that the paper was becoming more cunning each year.
"It used to be easy. You'd glance though the usual stories about Bulgarians raping NHS nurses because Brussels said it was their human right and you'd find some informative piece accurately describing the impact of new legislation without so much as a claim that is was a threat to British society. But in recent years, they've gotten harder to spot.
"Last year they hid an accurate snippet about the various branches of Islam as a small info box within a larger article about how councils were banning Easter church services because it might offend Muslims. Hiding in plain sight. Like the Romanians."
Mr Williams said he enjoyed what Express readers call the 'Easter egg hunt' and that this year the paper had offered several good options.
"It's a pickle. There's one piece about how Brexit will make the average UK family 40% richer by next year. That looks legit because the information comes from an Institute and those can't be set up by any old idiot. But then again there's that article in the health section telling us how Marmite causes cancer.
"That one had a picture of someone in a lab coat."
Posted on 1st April


Neutrophils are the most abundant type of granulocytes and the most abundant (40% to 70%) type of white blood cells in most mammals. They are a significant part of the innate immune system. Their functions vary from animal to animal. read on more neutrophil function.
Neutrophil function is a type of white blood cells. In fact, most white blood cells that lead to immune responses are neutrophils. There are four other types of white blood cells. Neutrophils are the most abundant, representing between 55 and 70 percent of your white blood cells. White blood cells, also called leukocytes, are a key part of the immune system.
In neutrophil function, your immune system consists of tissues, organs, and cells. As part of this complex system, white blood cells patrol your blood system and lymphatic system. When you are sick or have minor injuries, substances that your body perceives as foreign, called antigens, call your immune system action.
bacteria, viruses, mushrooms, poison, Cancer cells, White blood cells produce chemicals that fight antigens by going to the source of infection or inflammation.
Neutrophils are important because, unlike other white blood cells, they are not limited to a specific area of circulation. They can move freely through the walls of veins and body tissues to immediately attack all antigens.
An absolute neutrophil count (ANC) can provide your doctor with important information about your health. ANC is usually ordered as part of a complete blood count (CBC) with differentiation. CBC measures cells in the blood.
Your doctor may order ANC: display several conditions to help diagnose the condition monitor your status if you already have a disease or undergo chemotherapy. If your ANC is abnormal, your doctor will probably want to repeat your blood test several times in a few weeks. In this way, they can monitor changes in the number of neutrophils.
some medicines, including those used in chemotherapy, suppressed the immune system, bone marrow failure, aplastic anemia neutropenia with fever, which is an urgent medical case congenital disorders such as Kostmann syndrome and cyclic neutropenia hepatitis A, B or C. HIV / AIDS, sepsis, autoimmune diseases, including rheumatoid arthritis, leukemia, myelodysplastic syndromes.
The risk of infection is greatest if the neutrophil count drops below 1 500 neutrophils per microliter. Very low neutrophil counts can lead to life-threatening infections.
Neutropenia or neutropenia is an abnormally low level of neutrophils (a type of white blood cell) in the blood. Neutrophils constitute the majority of circulating white blood cells and serve as the basic protection against infections by destroying bacteria, fragments of bacteria and viruses associated with immunoglobulins in the blood. Persons with neutropenia are more susceptible to bacterial infections and without prompt medical care, this condition may be life-threatening (neutropenic sepsis).
Congenital neutropenia occurs from birth. Severe congenital neutropenia is also called Kostmann syndrome. This causes very low levels of neutrophils. In some cases, neutrophils are absent. This exposes infants and young children to serious infections.
Cyclic neutropenia causes the neutrophil count to change in the 21-day cycle. The neutrophil count drops from normal to low. The period of neutropenia can last for several days. Normal levels follow the rest of the cycle. The cycle resets and starts again.
In autoimmune neutropenia, your body produces antibodies that fight your neutrophils. These antibodies kill neutrophil function and this causes neutropenia. Autoimmune neutropenia develops in later life.
Idiopathic neuropathy develops at any time in life and can affect everyone. The cause is unknown.
Symptoms of neutropenia may range from mild to severe. The lower the level of neutrophils, the more intense the symptoms.
fever, pneumonia, sinus infections, otitis media or ear infection, gingivitis or gingivitis, inflammation of the palate or navel infection cutaneous abscesses Severe congenital neutropenia may have serious symptoms. Symptoms often include bacterial infections. These infections can develop on the skin, in the digestive and respiratory tract. Symptoms of cyclic neutropenia recur in three-week cycles. Infections can grow when neutrophil function levels fall. Symptoms of autoimmune and idiopathic neutropenia include infection. Usually, they are not as serious as those in congenital forms.
Neutropenia can be triggered by chemotherapy, radiotherapy, use of some medicines, Other reasons are: Shwachman-Diamond syndrome, which is a congenital condition affecting the bone marrow and pancreatic insufficiency Glycogen-type 1b inflammatory disease, which is a rare inherited disorder that affects blood sugar levels: leukemia, viral disease, severe aplastic anemia, Fanconi anemia, conditions that affect the bone marrow According to the American National Library, most people with severe congenital neutropenia do not have a family history of this disease.


text:
Jo Malone and A Pea in the Pod Open at The Gardens Mall
Posted on Sep 14 2016 - 10:07am by Cristyle
Jo Malone and A Pea in the Pod Open at The Gardens Mall; Chico's Undergoes Renovations
In its ongoing effort to provide an unprecedented shopping experience for local shoppers and visiting guests, The Gardens Mall is pleased to announce recent renovations and two store openings to its expanding retail portfolio.
"We're thrilled to welcome Jo Malone London and A Pea in the Pod into The Gardens Mall family," said Michele Jacobs, Corporate Director of Marketing and Operations for The Forbes Company. "Shoppers now have two new destinations when it comes to the premier in fine fragrances and designer must-haves for expectant mothers."
Beautiful packaging and exquisite presentation is synonymous with Jo Malone London. The 757-square-foot fragrance boutique showcases a trove of chic beauty essentials, including British bespoke perfumes, skin care, scented candles, and bath and body products. Select from the original modern classic, Lime Basil & Mandarin, to the exclusive, ultra luxurious Rare Teas collection. Décor elements pop at Jo Malone, which mixes classic English furnishings with glittering chandeliers and the brand's signature black and cream colors. Guests are encouraged to play perfumer with fragrance combining, or indulge in a hand and arm massage at the Tasting Bar. Located on the first level between Robert Graham and Ecco.
Modern maternity is the name of the game at A Pea in the Pod. The luxurious, 1,200-square-foot store features the brand's own collections, as well as modern, designer brands, including Splendid, BCBG, David Lerner, Rachel Pally, Love Sam, and London-based maternity line Isabella Oliver. Guests will love A Pea in the Pod's patented Secret Fit Belly®, a seamless, stretchy maternity panel that can be worn up or down for custom support and coverage. These maternity denim styles can be worn during all stages of pregnancy and post baby. In addition to clothing, the store also showcases nursing apparel, accessories, and skin care, and offers complimentary bra fittings. Located on the second level near Bloomingdale's.
Recently, Chico's completed a major redesign of their 4,388-square-foot store. Infused with a "chic European vibe," guests are welcomed by a modern storefront of travertine-like tile with dark-brown wood accents. The revitalized space also reveals glass-paneled jewelry vitrines, stylish décor, and lighting fixtures. More features include updated fitting rooms, additional seating, and new jewelry and accessories ensconced on display boards. Located on the first level next to Godiva.
About The Gardens Mall
The Gardens Mall is located one mile east of I-95 on PGA Blvd. in Palm Beach Gardens, Florida. The luxurious, 1.4-million-square-foot, super-regional shopping center features more than 150 world-class retail specialty shops and restaurants. It is anchored by Saks Fifth Avenue, Nordstrom, Bloomingdale's, and Macy's. The Gardens Mall is owned and managed by The Forbes Company. For more information about The Gardens Mall, call 561.775.7750 or visit the mall online at thegardensmall.com or floridaluxuryshopping.com.
Cristyle
Founder at EatPalmBeach.com
Cristyle is a South Florida native, born in Miami and raised in Palm Beach. Her love of food came through her travels and seeing how cuisines differ and relate so much. She attended the University of Florida, had a short stint in Charlotte, NC and is now back home - ready to eat her way through Palm Beach County and share her findings with locals and visitors alike. From brunch to happy hour to foodie events, she's got you covered!
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text:
On Changing Reading Habits or Savoring the Experience
Lee Mandelo
Tue Nov 29, 2011 11:00am 11 comments Favorite This
Having just finished reading the fantastic collection 80! Memories & Reflections on Ursula K. Le Guin (ed. Karen Joy Fowler and Debbie Notkin), I've started thinking about the ways in which my reading habits have changed over the years—mostly because of one thing, which I'll now confess:
I haven't read all of Le Guin's books. Or, even half. Not for the reasons you might suspect, though; certainly not from a lack of enthusiasm or desire. Ursula K. Le Guin is one of our best, as 80! makes a point of exploring in loving detail, and reading her is a treat beyond compare. Her prose is complex, handsome, and challenging in the best ways, her worlds are anchored so deftly in anthropological and linguistic detail that they never seem less than immediate, and her characters fill all walks of life in their worlds and ours.
If I had encountered her first as a teenager, I would have read her entire bibliography at once, gorging myself on the beauty, the stunning prose, the sensation of wonder that reliably comes on the heels of "The End." It would have been a great month or two, and would have left me exhausted at the end. That was just how I preferred to read: find a new author, devour everything they've ever done that I can get my hands on.
Not that there's a damn thing wrong with a reading orgy; I know a great many people who prefer to dive in head first when they find a new favorite. I'm sure there are plenty of folks reading this who are nodding along in agreement.
But, my reading habits have changed, and thinking on my engagement with Le Guin's oeuvre has driven that point home. I have a nicely sized stack of her novels and collections on a shelf in my library; some are well-thumbed, but some are pristine, waiting to be read. And I like it that way. Reading is a pleasure that drives away the dark, that can make a truly foul day better, that can bring beauty and awe to an otherwise disappointing week or month or year—reading something as skilled and breath-taking as Le Guin's books, especially.
So, I'm savoring it. I have my pile of books, unread, that I know I will love when I sit down with one. They're something to look forward to, to parcel out like pearls on a string. Instead of reading them all at once, they will likely last me years. That's a lot of bright spots, scattered out as rewards and presents-to-myself. That is how I plan on interacting with this astounding body of work which has already made lasting, lifelong impressions on me and will no doubt continue to do so.
Reading the ways in which other people have interacted with Le Guin's books over their lives in 80! was moving, nearly to the point of tears in some essays. The differences books like The Left Hand of Darkness or The Dispossessed or Four Ways to Forgiveness or Earthsea can make in a reader's life cannot be understated, and the writers of the appreciations, essays, and tributes in 80! have all bared their souls in their explorations of what Le Guin has done for them.
For me, her work has been an island of revelation, pleasure, and genuine awe in often difficult times. I'm not entirely certain if The Left Hand of Darkness was the definitive turning point of my habits as a reader—if there's such a thing as a definitive turning point—but it was one of the books I most remember putting down at the end in silence, so astounded that I could not bear the thought of picking up another piece of fiction afterwards. It needed space around it, space to be appreciated deeply, intensely, for all of the work it does (and doesn't) do. I could not move on to the next in the pile, could not devour them all at once.
So, in the spirit of 80!, which has inspired this set of thoughts on reading: thank you, Ursula K. Le Guin, for stunning me so thoroughly that I could not just keep going, and for introducing me however unintentionally to the pleasure of savoring brilliant books one at a time, over time.
And in the spirit of audience participation: how do you prefer to read? Devouring all at once, or savoring slowly?
[Edit: Jo Walton asked a similar question in regards to individual books back in August 2010 if you're interested in more crowd-sourced detail on reading habits.]
Brit Mandelo is a multi-fandom geek with a special love for comics and queer literature. She can be found on Twitter and Livejournal.
readingreading habitsUrsula K. Le Guin
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text:
Ana Christina D. S., Joiceline C. D. S. and Marcia D. S.
Ana Christina D. S. (31), Joiceline C. D. S. (32) and Marcia D. S. (40), all Brazilian nationals, pleaded guilty to running a brothel out of their apartment. The court heard 6 mobile phones, a laptop and €500 was seized [...]
Saray B. M.
Saray B. M. (28), a Spanish national, was charged with brothel keeping after her apartment in Westport, Co. Mayo was raided by Gardaí on 27 January 2009 and they found her with a semi-naked male who said he'd paid her [...]
Helen D. C.
Helen D. C. (22), a Brazilian national, pleaded guilty to brothel keeping in Limerick on 25 August 2009 and apologised. The court heard she had come to Ireland to study English and began working as a prostitute as a brief [...]
Aneldy S. S., Josefa Maria D. S., Michelle D. P., Monica A. D. L., Sarah Silviane D. R. and Suely T. D. S.
Aneldy S. S. (32), Josefa Maria D. S. (36), Michelle D. P. (28), Monica A. D. L. (34), Sarah Silviane D. R. (22) and Suely T. D. S. (40), all Brazilian nationals and all of no fixed abode, pleaded guilty [...]
Blanka V.
Blanka V. (24), a Czech national, was arrested and charged with brothel keeping following a Garda raid on her apartment in Limerick on 11 February 2009 where items suggesting prostitution were found. These items included sex aids, three mobile phones, [...]
Charity Donation / Poor Box (13) Condoms as Evidence (11) Controlled / Trafficked (17) Female (79) Fined (47) Living on Earnings (3) Lone Worker (15) Male (5) Money Seized (37) Mother (22) No Fixed Abode (4) No Legal Representation (2) Not Controlled / Trafficked (19) Pleaded Not Guilty (3) Poverty (26) Prison Sentence (20) Property Seized (27) To Leave Jurisdiction (42) Trans (3)
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Clare (1)
Donegal (9)
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Kerry (6)
Kildare (3)
Leitrim (5)
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Meath (1)
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Roscommon (1)
Sligo (10)
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Wexford (2)