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text:
Enantioseparation of Cinacalcet, and its Two Related Compounds by HPLC with Self-Made Chiral Stationary Phases and Chiral Mobile Phase Additives
Author(s): Canyu Yang, School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan 650500, China	Ji Li, School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan 650500, China	Yanyun Yao, Dali Nursing Vocational College, Dali, Yunnan, 671000, China	Chen Qing*, School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan 650500, China	Baochun Shen*	School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan 650500, China
Journal Name: Current Pharmaceutical Analysis
Background: Cinacalcet is one of the second-generation calcimimetics which consists of a chiral center. The pharmacological effect of R-cinacalcet is 1000 times greater than that of the Scinacalcet. As mentioned in many literatures, 1-(1-naphthyl)ethylamine is used as the starting material for the synthesis of cinacalcet. The absolute structure of cinacalcet is influenced by the starting materials.
Methods: We present the chiral separation of cinacalcet and its starting material, 1-(1-naphthyl) ethylamine along with one of its intermediates, N-(1-(naphthalen-1-yl) ethyl)-3- (3-(trifluoromethyl) phenyl) propanamide by high-performance liquid chromatography with chiral stationary phase and chiral mobile phase additives.
Results: On vancomycin and cellulose tri 3,5-dimethylphenylcarbamate) chiral stationary phase, cinacalcet and 1-(1-naphthyl)ethylamine achieved enantioseparation under normal phase with addition of triethylamine additives, respectively. Meanwhile, 1-(1-naphthyl)ethylamine and N-(1-(naphthalen-1- yl)ethyl)-3-(3-(trifluoromethyl) phenyl) propanamide achieved enantioseparation on 1-napthalene vancomycin chiral stationary phase using D-tartaric acid, diethyl L-tartrate and diethyl D-tartrate as chiral mobile phase additives.
Conclusion: The chiral recognition in our experiment was based on the hydrogen-bonding, dipoledipole and π-π interactions among the solutes, chiral stationary phases and chiral mobile phase additives. In addition, the space adaptability of chiral stationary phases also affected the separation efficacy.
Keywords: Enantioseparation, cinacalcet, 1-(1-naphthyl) ethylamine, N-(1-(naphthalen-1-yl) ethyl)-3- (3-(trifluoromethyl) phenyl) propanamide, chiral mobile phase additive, chiral stationary phase.
Barniol-Xicota, M.; Leiva, R.; Escolano, C.; Vázquez, S. Syntheses of cinacalcet: An enantiopure active pharmaceutical ingredient (API). Synthesis, 2016, 48, 783-803.
Torres, P.U. Cinacalcet HCl: A novel treatment for tertiary hyperparathyroidism caused by chronic kidney disease. J. Ren. Nutr., 2006, 16, 253-258.
Nemeth, E.F.; Heaton, W.H.; Miller, M.; Fox, J.; Balandrin, M.F.; Van Wagenen, B.C.; Colloton, M.; Karbon, W.; Scherrer, J.; Shatzen, E.; Rishton, G.; Scully, S.; Qi, M.; Harris, R.; Lacey, D.; Martin, D. Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl. J. Pharmacol. Exp. Ther., 2004, 308, 627-635.
Brauner-Osborne, H.; Wellendorph, P.; Jensen, A. Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors. Curr. Drug Targets, 2007, 8, 169-185.
Siddiqui, M.R.; AlOthman, Z.A.; Rahman, N. Analytical techniques in pharmaceutical analysis: A review. Arab. J. Chem., 2017, 10, S1409-S1421.
AlOthman, Z.A.; Rahman, N.; Siddiqui, M.R. Review on pharmaceutical impurities, stability studies and degradation products. Rev. Adv. Sci. Eng., 2013, 2, 155-166.
Rahman, N.; Azmi, S.N.H.; Wu, H.F. The importance of impurity analysis in pharmaceutical products: an integrated approach. Accredit. Qual. Assur., 2006, 11, 69-74.
Shinde, G.B.; Niphade, N.C.; Deshmukh, S.P.; Toche, R.B.; Mathad, V.T. Industrial application of the forster reaction: novel one-pot synthesis of cinacalce hydrochloride, a calcimimetic agent. Org. Process Res. Dev., 2014, 15, 455-461.
Ravinder, V.; Ashok, S.; Satish, V.M.; Raghunath, B.C.V.; Shanker, K.; Balaswamy, G. A validated chiral LC method for the enantiomeric separation of cinacalcet hydrochloride. Chromatographia, 2009, 70, 229-232.
Bhushan, R.; Dubey, R. Indirect reversed-phase high-performance liquid chromatographic and direct thin-layer chromatographic enantioresolution of (R, S) cinacalcet. Biomed. Chromatogr., 2011, 25, 674-679.
Dousa, M.; Brichác, J. Chiral chromatography studies of chemical behavior of cinacalcet on polysaccharide chiral reversed-phase HPLC stationary phase. J. AOAC Int., 2012, 95, 1639-1643.
Ramisetti, N.R.; Bompelli, S. LC-MS/MS determination of cinacalcet enantiomers in rat plasma on Chirobiotic V column in polar ionic mode: Application to a pharmacokinetic study. Biomed. Chromatogr., 2014, 28, 1846-1853.
Mei, X.M.; Chen, W. Determination of enantiomer of R-1-(1-naphthyl) ethylamine by HPLC. West Chin J. Pharm. Sci., 2014, 29, 75-76.
Mei, X.M.; Chen, W.; Bai, Z.W. Enantioseparation characteristics of the chiral stationary phases based on natural and regenerated chitins. J. Sep. Sci., 2017, 40, 1710-1717.
Younes, A.A.; Ates, H.; Mangelings, D.; Vander, H.Y. A separation, strategy combining three HPLC modes and polysaccharide-based chiral, stationary phases. J. Pharmaceut. Biomed., 2013, 75, 74-85.
Armstrong, D.W.; Tang, Y.B.; Chen, S.S.; Zhou, Y.W.; Bagwill, C.; Chen, J.R. Macrocyclic antibiotics as a new class of chiral selectors for liquid chromatography. Anal. Chem., 1994, 66, 1473-1484.
Armstrong, D.W.; Zhang, B. Chiral stationary phases for HPLC. Anal. Chem., 2001, 73, 557A-561A.
Felix, G.; Berthod, A. Commercial chiral stationary phases for the separation of clinical racemic drugs. Separ. Purif. Rev., 2007, 36, 285-481.
Berthod, A.; Xiao, T.L.; Bagwill, C.; Armstrong, D.W. Separation of chiral sulfoxides by liquid chromatography using macrocyclic glycopeptides chiral stationary phases. J. Chromatogr. A, 2002, 955, 53-59.
Berthod, A. Chiral recognition mechanisms with macrocyclic glycopeptide selectors. Chirality, 2009, 21, 167-175.
Zhang, Z.; Yang, G.; Liang, G.; Liu, H.; Chen, Y. Chiral separation of Tamsulosin isomers by HPLC using cellulose Tris (3, 5-dimethhylphenylcarbamate) as a chiral stationary phase. J. Pharmaceut. Biomed., 2004, 34, 689-693.
Ceccato, A.; Hubert, P.; Tullio, P.D.; Liégeois, J.F.; Felikidis, A.; Géczy, J. Enantiomeric separation of pirlindole by liquid chromatography using different types of chiral stationary phases. J. Pharmaceut. Biomed., 1998, 18, 605-614.
Zhang, T.; Nguyen, D.; Franco, P.; Isobe, Y.; Michishita, T.; Murakami, T. Cellulose, tris (3, 5-dichlorophenylcarbamate) immobilised on silica: A novel chiral stationary phase for resolution of enantiomers. J. Pharmaceut. Biomed., 2008, 46, 882-891.
Okamoto, Y.; Kaida, Y. Resolution by high-performance liquid chromatography using polysaccharide carbamates and benzoates as chiral stationary phases. J. Chromatogr. A, 1994, 666, 403-419.
He, H.M.; Xu, X.Z.; Zhang, D.T.; Chen, J.J. Enantioseparation of alkyl tropate by high performance liquid chromatography using (2R, 3R)-di-n-propyl tartrate. Anal. Chim. Acta, 2005, 536, 15-20.
Pan, C.X.; Shen, B.C.; Xu, B.J.; Chen, J.J.; Xu, X.Z. Comparative enantioseparation of seven triazole fungicides on (S, S)-Whelk O1 and four different cellulose derivative columns. J. Sep. Sci., 2006, 29, 2004-2011.
Shao, B.H.; Xu, X.Z.; Lv, J.D.; Cai, X.J.; Fu, X.Y. Enantioseparations of three kinds of methoxyflavanones on cellulose derivative chiral columns and chiral recognition mechanism. Acta Chimi. Sin., 2003, 61, 440-443.
Shen, B.C.; Yuan, J.Y.; Wang, H.C.; Xu, B.J.; Xu, X.Z. Enantioseparation of three aryloxyphenoxypropionic acids herbicides on CDMPC and vancomvcin CSP column. J. Instrum. Anal., 2008, 27, 1379-1382.
Shen, B.C. The preparation and enantioseparation of macrocyclic antibiotics and their derivatives chiral stationary phase. PhD Thesis, Zhejiang University, Zhejiang, China,, 2007.
Yu, X.Y.; Gu, X.J.; Xie, Y.; Qu, S.L.; Shen, B.C. Separation of enantiomers of 6 alkamine drugs on 1-napthalene vancomycin chiral stationary phase. PTCA (Part B: Chem. Anal.),, 2012, 48, 884-892.
Shen, B.C.; Xu, X.Z.; Zhang, X.J.; Chen, J.J. Enantioseparation and chiral recognition mechanism of two novel organic phosphonate derivatives on chiral stationary phases. Anal. Lett., 2005, 38, 1317-1330.
open access plus
Current Pharmaceutical Analysis
Title:Enantioseparation of Cinacalcet, and its Two Related Compounds by HPLC with Self-Made Chiral Stationary Phases and Chiral Mobile Phase Additives
Author(s):Canyu Yang, Ji Li, Yanyun Yao, Chen Qing* and Baochun Shen*
Affiliation:School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan 650500, School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan 650500, Dali Nursing Vocational College, Dali, Yunnan, 671000, School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan 650500, School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan 650500
Keywords:Enantioseparation, cinacalcet, 1-(1-naphthyl) ethylamine, N-(1-(naphthalen-1-yl) ethyl)-3- (3-(trifluoromethyl) phenyl) propanamide, chiral mobile phase additive, chiral stationary phase.
Abstract:Background: Cinacalcet is one of the second-generation calcimimetics which consists of a chiral center. The pharmacological effect of R-cinacalcet is 1000 times greater than that of the Scinacalcet. As mentioned in many literatures, 1-(1-naphthyl)ethylamine is used as the starting material for the synthesis of cinacalcet. The absolute structure of cinacalcet is influenced by the starting materials.
Canyu Yang, Ji Li, Yanyun Yao, Chen Qing* and Baochun Shen*, "Enantioseparation of Cinacalcet, and its Two Related Compounds by HPLC with Self-Made Chiral Stationary Phases and Chiral Mobile Phase Additives", Current Pharmaceutical Analysis (2019) 15: 200. https://doi.org/10.2174/1573412914666180518105046
Published on: 04 January, 2019
Page: [200 - 209]
PDF: 36
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Method Development & Validation of LCMS/MS for Atorvastatin and Olmesartan in Human Plasma to Trace Drug Interaction of Formulation
Immobilized Polysaccharide CSPs: An Advancement in Enantiomeric Separations
Development and Validation of a Novel Reversed Phase High Performance Liquid Chromatography with Refractive Index Detector Method for Assay of Polyvinyl Alcohol in an Ophthalmic Solution
Lipid Disorders in Diabetes Mellitus and Current Management
A Reliable HPLC-ELSD Method for Determination of Cholesterol, Phosphatidylcholine, Lysophosphatidylcholine Content and the Stability of a Liposomal Formulation
Simultaneous and Sensitive Determination of Amphetamine, Codeine and Morphine in Exhaled Breath Condensate, Using Capillary Electrophoresis Coupled with On-line and Off-line Enhancing Methods
Chemically Modified Electrodes in Electrochemical Drug Analysis
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Determination of Inorganic Element Concentrations in Nardostachys jatamansi DC

redpajama_set_name: RedPajamaCommonCrawl


text:
package me.imli.shareanima.view;

import android.content.Context;
import android.graphics.Matrix;
import android.graphics.drawable.Drawable;
import android.util.AttributeSet;
import android.widget.ImageView;

public class CropImageView extends ImageView{

	private boolean topCrop = true;

	public CropImageView(Context context, AttributeSet attrs, int defStyle) {
		super(context, attrs, defStyle);
		// TODO Auto-generated constructor stub
	}

	public CropImageView(Context context, AttributeSet attrs) {
		super(context, attrs);
		// TODO Auto-generated constructor stub
	}

	public CropImageView(Context context) {
		super(context);
		// TODO Auto-generated constructor stub
	}

	public boolean isTopCrop() {
		return topCrop;
	}

	public void setTopCrop(boolean topCrop) {
		this.topCrop = topCrop;
		if(topCrop){
			invalidate();
		}
	}

	@Override
    protected boolean setFrame(int l, int t, int r, int b) {
		if(topCrop){
            Drawable drawable = super.getDrawable();

            if (drawable != null) {
                float floatLeft = (float) l;
                float floatRight = (float) r;

                float intrinsicWidth = drawable.getIntrinsicWidth();
                float intrinsicHeight = drawable.getIntrinsicHeight();

                int frameHeight = b - t;

                if (intrinsicWidth != -1) {
                    float scaleFactor = (floatRight - floatLeft) / intrinsicWidth;

                    if (scaleFactor * intrinsicHeight < frameHeight) {
                        setScaleType(ScaleType.FIT_CENTER);
                    } else {
                        setScaleType(ScaleType.MATRIX);
                        Matrix matrix = new Matrix();
                        // scale width
                        matrix.setScale(scaleFactor, scaleFactor);
                        setImageMatrix(matrix);
                    }

                }
            }
        }

        return super.setFrame(l, t, r, b);
    }
}

redpajama_set_name: RedPajamaGithub


text:
from django.core.exceptions import FieldError
from django.test import TestCase

from .models import (
    Entry,
    Line,
    Post,
    RegressionModelSplit,
    SelfRefer,
    SelfReferChild,
    SelfReferChildSibling,
    Tag,
    TagCollection,
    Worksheet,
)

class M2MRegressionTests(TestCase):
    def test_multiple_m2m(self):
        # Multiple m2m references to model must be distinguished when
        # accessing the relations through an instance attribute.

        s1 = SelfRefer.objects.create(name="s1")
        s2 = SelfRefer.objects.create(name="s2")
        s3 = SelfRefer.objects.create(name="s3")
        s1.references.add(s2)
        s1.related.add(s3)

        e1 = Entry.objects.create(name="e1")
        t1 = Tag.objects.create(name="t1")
        t2 = Tag.objects.create(name="t2")

        e1.topics.add(t1)
        e1.related.add(t2)

        self.assertSequenceEqual(s1.references.all(), [s2])
        self.assertSequenceEqual(s1.related.all(), [s3])

        self.assertSequenceEqual(e1.topics.all(), [t1])
        self.assertSequenceEqual(e1.related.all(), [t2])

    def test_m2m_managers_reused(self):
        s1 = SelfRefer.objects.create(name="s1")
        e1 = Entry.objects.create(name="e1")
        self.assertIs(s1.references, s1.references)
        self.assertIs(s1.related, s1.related)
        self.assertIs(e1.topics, e1.topics)
        self.assertIs(e1.related, e1.related)

    def test_internal_related_name_not_in_error_msg(self):
        # The secret internal related names for self-referential many-to-many
        # fields shouldn't appear in the list when an error is made.
        msg = (
            "Choices are: id, name, references, related, selfreferchild, "
            "selfreferchildsibling"
        )
        with self.assertRaisesMessage(FieldError, msg):
            SelfRefer.objects.filter(porcupine="fred")

    def test_m2m_inheritance_symmetry(self):
        # Test to ensure that the relationship between two inherited models
        # with a self-referential m2m field maintains symmetry

        sr_child = SelfReferChild(name="Hanna")
        sr_child.save()

        sr_sibling = SelfReferChildSibling(name="Beth")
        sr_sibling.save()
        sr_child.related.add(sr_sibling)

        self.assertSequenceEqual(sr_child.related.all(), [sr_sibling.selfrefer_ptr])
        self.assertSequenceEqual(sr_sibling.related.all(), [sr_child.selfrefer_ptr])

    def test_m2m_pk_field_type(self):
        # Regression for #11311 - The primary key for models in a m2m relation
        # doesn't have to be an AutoField

        w = Worksheet(id="abc")
        w.save()
        w.delete()

    def test_add_m2m_with_base_class(self):
        # Regression for #11956 -- You can add an object to a m2m with the
        # base class without causing integrity errors

        t1 = Tag.objects.create(name="t1")
        t2 = Tag.objects.create(name="t2")

        c1 = TagCollection.objects.create(name="c1")
        c1.tags.set([t1, t2])
        c1 = TagCollection.objects.get(name="c1")

        self.assertCountEqual(c1.tags.all(), [t1, t2])
        self.assertCountEqual(t1.tag_collections.all(), [c1])

    def test_manager_class_caching(self):
        e1 = Entry.objects.create()
        e2 = Entry.objects.create()
        t1 = Tag.objects.create()
        t2 = Tag.objects.create()

        # Get same manager twice in a row:
        self.assertIs(t1.entry_set.__class__, t1.entry_set.__class__)
        self.assertIs(e1.topics.__class__, e1.topics.__class__)

        # Get same manager for different instances
        self.assertIs(e1.topics.__class__, e2.topics.__class__)
        self.assertIs(t1.entry_set.__class__, t2.entry_set.__class__)

    def test_m2m_abstract_split(self):
        # Regression for #19236 - an abstract class with a 'split' method
        # causes a TypeError in add_lazy_relation
        m1 = RegressionModelSplit(name="1")
        m1.save()

    def test_assigning_invalid_data_to_m2m_doesnt_clear_existing_relations(self):
        t1 = Tag.objects.create(name="t1")
        t2 = Tag.objects.create(name="t2")
        c1 = TagCollection.objects.create(name="c1")
        c1.tags.set([t1, t2])

        with self.assertRaisesMessage(TypeError, "'int' object is not iterable"):
            c1.tags.set(7)

        c1.refresh_from_db()
        self.assertSequenceEqual(c1.tags.order_by("name"), [t1, t2])

    def test_multiple_forwards_only_m2m(self):
        # Regression for #24505 - Multiple ManyToManyFields to same "to"
        # model with related_name set to '+'.
        foo = Line.objects.create(name="foo")
        bar = Line.objects.create(name="bar")
        post = Post.objects.create()
        post.primary_lines.add(foo)
        post.secondary_lines.add(bar)
        self.assertSequenceEqual(post.primary_lines.all(), [foo])
        self.assertSequenceEqual(post.secondary_lines.all(), [bar])


text:
Solemnity of Peter and Paul
On Friday, June 29, the Solemnity of Sts. Peter and Paul, Pope Benedict XVI will bestow the pallium on 38 metropolitan archbishops, including 14 from Europe and six from North America. The Americans are: Archbishops Jerome Listecki of Milwaukee, Wisconsin; Dennis Schnurr of Cincinnati, Ohio; and Thomas Wenski of Miami, Florida.
The vestment is called a "pallium," (plural is "pallia") and it is a narrow band of cloth woven of white lamb's wool with a ring in the center which rests on the shoulders of its wearer. The narrow band falls down the front of the chest like a necktie and goes similarly down the back. It is decorated with six black crosses, one on each tail and four on the loop. The pallium has its origin as a liturgical vestment of the Holy Father since at least the 4th century, and it has been given to each Metropolitan Archbishop since at least the 9th century.
Worn by the pope, the pallium symbolizes the plenitudo pontificalis officii (i.e., the "fullness of Pontifical office"). When worn by Metropolitan Archbishops, it signifies the power which the Metropolitan, in communion with the Roman Church, has by law in his own province.
The story of how the pallium is made gives clues to its symbolism. The wool comes from lambs raised by Trappist monks. On, January 21, the Feast of St. Agnes ("agnes" is from the Latin word for lamb), the lambs whose wool is destined for the making of the pallia are solemnly blessed at the Basilica of Saint Agnes. However, during the last three years, the Holy Father has blessed these lambs himself at the Vatican. Wool from these lambs is then given to the Benedictine nuns of the Basilica of St Cecilia in Trastevere, and they weave the pallia. The new pallia are solemnly blessed at the Basilica of St. Peter after the Second Vespers on the feast of Sts. Peter and Paul, and are then stored in a special golden chest located directly above the original tomb of St. Peter. It is called the "Niche of the Pallia."
If you're ever at St Louis Cathedral on a Sunday, notice Archbishop Gregory Aymond's pallium. It's a great reminder of the universality and long history of our Church.
Filed Under: home-left


The interior was elegantly furnished with an art collection of great value, many beautiful objects contributing harmony to the overall environment. The villa has become one of the most lively cultural salons of the time.
The villa near Florence is an ideal venue for chic symbolic wedding ceremony in Tuscany. You will pass the most important day in your life in a paradise, away from the hustle and bustle, and will be just in 15 minutes from the busy city. You can choose any part of this splendid villa or a wonderful shady park, for the realization with our help of your wedding dream.


The measures taken by the Palestinian Authority to cut the salaries of public sector employees in the Gaza Strip, and other measures that have affected the residents of the Gaza Strip since March 2017, began with the announcement of the formation of the administrative committee to manage the situation in the Gaza Strip. This derived from the continued failure of the internal reconciliation efforts, in an attempt to pressure Hamas to end its control over Gaza.
In light of this, President Mahmoud Abbas announced a series of measures that have been implemented in the Gaza Strip since April 2017. The most prominent of these is the measure taken by the Ministry of Finance to deduct 30 to 35 per cent of the salaries of all employees in the Gaza Strip (about 62,000 employees), the termination of certain functional financial benefits such as supervisory bonus for employees, transportation allowance, and social allowance, and the reduction of patient referrals for medical treatment outside of the Gaza Strip by a large percentage (about 80 per cent of the referrals usually given in the Gaza Strip, including for cancer patients and patients suffering other serious diseases). Measures have also included halting the supply of electricity to Gaza's power plant, leading to severe power cuts for long hours, in the context of Israel's prolonged closure of the Gaza Strip, which has created a crisis and violates a vast spectrum of civil, political, economic, social, and cultural rights to which Palestinians in the Gaza Strip are entitled, including their right to dignity.
These measures taken by the President and the Palestinian Government, were adopted without a Law by Decree or presidential decree or Government decision, and were met with wide-ranging objections by Palestinian civil society organizations for violating the provisions of the Palestinian Basic Law (Interim Constitution), in particular Article 9, which prohibits discrimination between Palestinians. Al-Haq has stated that the above measures amount to discrimination on a geographical basis, as they solely target Palestinian employees in the Gaza Strip and employees from the Gaza Strip residing in the West Bank. The measures further violate economic and social rights enshrined in international human rights treaties to which the State of Palestine has acceded.
In July 2017, 6,145 civil servants from the Gaza Strip were referred to forced early retirement. In addition, in November 2017, some 7,000 military personnel from the Gaza Strip were further referred to forced early retirement. It is to be noted that at the time, the total number of Palestinian civil servants and military personnel of the Palestinian Authority (i.e. those receiving salaries from the Palestinian Authority including in the Gaza Strip) was estimated at approximately 156,000 employees, of whom about 94,000 were in the West Bank and 62,000 in the Gaza Strip, including 26,000 civil servants and 36,000 military personnel.
On 9 April 2018, the Ministry of Finance transferred the salaries of West Bank civil servants and military personnel to their bank accounts. However the salaries of Palestinian Authority employees in the Gaza Strip were not transferred to their bank accounts. Several official statements referred to a "technical error" in the transfer process, although this pretext soon faded with the continued suspension of salaries of all employees in the Gaza Strip. Since then, no further official statements were made to explain why the salaries of all employees in the Gaza Strip continued to be suspended.
On 2 May 2018, the Ministry of Finance transferred the salaries of civil servants and military personnel in the West Bank to their bank accounts and, on the same date, transferred only 50 per cent of the salaries of employees in the Gaza Strip to their bank accounts. As for the salaries of Gaza Strip public employees for April 2018, they have still not been transferred to their bank accounts.
It should be noted that Al-Haq's field documentation and follow-up indicate that banks have complained about the measures taken against employees in the Gaza Strip, in particular since the proportion of employees who are borrowers from banks is at around 78 per cent. As such, the inability to collect the instalments and benefits of loans and bank commissions has had a direct impact on banking operations.
Al-Haq's follow-up further shows that following the decision by the Palestinian Ministry of Finance to transfer only 50 per cent of the total salary to the bank accounts of Gaza employees, the amount actually transferred is that of 50 per cent after the deduction made since April 2017 to reduce 30 to 35 per cent of the employees' total salary.
Meanwhile, 5,598 new jobs were officially approved in the general budget of the State of Palestine for the fiscal year 2018. It is to be noted that the Ministry of Finance and the Palestinian Government still refuse to present the general budget for public debate before its approval, in the absence of the Palestinian Legislative Council, despite the many requests by civil society organizations for the need to discuss the budget before its approval. The Ministry of Finance and the Government continue to ignore the demands by civil society in this regard. Despite the fact that one of the scenarios of the 2018 general budget indicated the possibility of appointing 20,000 employees in the Gaza Strip under the banner "Additional Budget for the Southern Governorates", the situation on the ground shows that the appointments are confined to the West Bank only without the Gaza Strip, bearing in mind that new civil service appointments in the Gaza Strip have been suspended since 2007 and that the average age of employees in the Gaza Strip is over 40 years.
In addition, in relation to the absence of transparency, there are many laws by decree that have been passed and are under discussion by the Council of Ministers, approved by the President, and published in the Official Gazette (Palestinian Chronicles) in a manner that appears to be confidential and without public debate, despite their importance and impact on the state of human rights and fundamental freedoms, such as the Law by Decree on Cybercrimes, amendments to the Law by Decree on the Supreme Constitutional Court, and the Law by Decree on the High Criminal Court.
It should also be noted that the concept of tamkin or "empowerment", which the President and the Prime Minister have repeatedly emphasized, continues to raise serious problems between the Palestinian leadership and Hamas since their October 2017 agreement.
Together with civil society organizations, Al-Haq has closely followed the measures taken by the State of Palestine in the Gaza Strip, including the cutting of employees' salaries, and has issued a number of statements and position papers, met with State officials, and organised lobbying and human rights advocacy campaigns. Al-Haq views these procedures as lacking in transparency as no law, decree, presidential decree, regulation, or Government decision was issued to provide them with legal grounds or justifications.
The actions taken against employees in the Gaza Strip and staff from Gaza residing in the West Bank further involve discrimination on a geographical basis, in violation of Article 9 of the amended Palestinian Basic Law, which explicitly states that Palestinians are equal before the law and prohibits discrimination between them.
These measures also contravene the Law on the Organization of the General Budget and Financial Affairs No. (7) of 1998 and its amendments, which does not permit the Minister of Finance or the Government not to transfer the salaries of employees of the Gaza Strip, as this action constitutes a violation of the implementation stage of the general budget and has no basis under the abovementioned law. Moreover, the measure constitutes a violation of the provisions of the Civil Service Law No. (4) of 1998 and its amendments and executive regulations, as there is no legal basis in the said law for deducting salaries of employees in the Gaza Strip by 30 to 35 per cent, a measure which is still ongoing.
The Law by Decree on the Early Retirement of Civil Servants No. 17 of 2017 and the Law by Decree on the Early Retirement of Palestinian Security Forces No. 9 of 2017, both issued by President Mahmoud Abbas based on Article 43 of the Palestinian Basic Law in light of the continued absence of the Palestinian Legislative Council, have not been subject to public debate. Both were met by objections from Al-Haq and civil society organizations, as they are in violation of the National Policy Agenda adopted by the Palestinian Government for the years 2017-2022 and titled "Putting Citizens First", in light of the secrecy surrounding the laws by decree discussed by the Government, approved by President Mahmoud Abbas, and officially published.
Moreover, these laws by decree are contrary to the constitutional provisions of Article 43 of the Basic Law, by which the President is bound, because the said constitutional provision requires a "state of necessity that can not be delayed" to be valid, whereas such a condition is not available in these cases. This is in addition to the absence of any grounds and objective and measurable criteria in these two laws by decree, upon which the referral of thousands of employees in the Gaza Strip to forced early retirement was carried out.
Article 2 of the Law by Decree on the Early Retirement of Civil Servants No. 17 of 2017 states: "[n]otwithstanding any other legislation, the Council of Ministers may refer any employee to early retirement with the recommendation of the head of his Government department." Article 4 of the the Law by Decree on the Early Retirement of Palestinian Security Forces No. 9 of 2017 provides the following: "[t]he Supreme Commander of the Palestinian security forces, by placement of the Officers' Committee, upon the recommendation of the commander of the Security Services, or the head of the Security Services, or the Chairman of the Commission, or the head of the security or military directorate, or the competent minister, may refer to early retirement any military personnel to whom the provisions of this law by decree apply." Thus, the early retirement referral process lacks the necessary foundations and criteria.
It should be noted that the Law by Decree on the Early Retirement for Civil Servants No. 17 of 2017 and the Law by Decree on the Early Retirement of Palestinian Security Forces No. 9 of 2017, have been used recently since February 2018 to refer some 200 civil servants in the West Bank to forced early retirement, and to dismiss an undetermined number of cases which Al-Haq continues to monitor. These include military personnel, in particular of the National Security Service, the police, and the Civil Defense, who have been forced into early retirement.
The Gaza Strip is an integral part of the State of Palestine. Along with the West Bank, including East Jerusalem, the Gaza Strip constitutes occupied Palestinian territory under international law. Accordingly, international humanitarian law and international human rights law apply therein.
Palestine was accorded non-member observer State status at the United Nations (UN) General Assembly in 2012 and has since 2014 acceded to a number of international treaties without reservations, notably core international human rights conventions. These include the International Covenant on Civil and Political Rights (ICCPR), the International Covenant on Economic, Social and Cultural Rights (ICESCR), the Convention on the Elimination of All Forms of Discrimination Against Women (CEDAW), the Convention on the Rights of the Child (CRC), and the Convention on the Rights of Persons with Disabilities (CRPD). The State of Palestine has made a commitment to enforce these international treaties in the West Bank and Gaza Strip at the level of its legislation and public policies, and in practical application on the ground, without reservations. As a result, the measures taken in the Gaza Strip, in addition to violating Palestinian law, also constitute violations of the international treaties to which the State of Palestine has acceded without reservations.
Any statements to the contrary, regardless of the reasons and justifications provided, would ultimately lead to the erroneous conclusion that international law and specifically international human rights treaties, to which the State of Palestine has acceded, only apply to the West Bank but not the Gaza Strip.
We stand before a serious affront to human dignity in the Gaza Strip, which affects some two million Palestinian citizens, including women, children, the elderly, and entire families, including those still forced to live in the open without shelter. The cutting of salaries of public sector employees affects the main and often only source of income of thousands of families in the Gaza Strip, along with relief assistance provided by the UN Relief and Works Agency for Palestine Refugees in the Near East (UNRWA), which is currently facing one of its most difficult funding crises yet. The series of measures taken by the State of Palestine in the Gaza Strip contributes to further deterioration in the already explosive situation therein and may lead to further increases in crime rates and domestic violence, which are already elevated as a result of rampant poverty, unemployment, destitution, loss of livelihood, deterioration of social and health conditions, and the destruction of the economy of the Gaza Strip, which remains under prolonged Israeli occupation and continues to suffer from the scourge of the Israeli-imposed closure.


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UK government to offer steel firms £600m to go green
The UK government is set to provide British Steel and Tata Steel with £600 million in funding to help the two steelmakers switch from coal-fired blast furnaces and to help with their energy costs. The BBC reports that the funding is set to be announced by Chancellor Jeremy Hunt this week in a move which will protect thousands of jobs.
Port Talbot steel works - Image: Shutterstock
As part of the funding deal being offered by the Department for Business, Energy and Industrial Strategy (BEIS), the steelmakers will be required to move away from their blast furnaces which run on coking coal.
The BBC reports that a £300 million package for British Steel, which is owned by Chinese company Jingye, could prevent the closure of its steel works in Scunthorpe, Lincolnshire and save hundreds of jobs.
Indian-owned Tata Steel is also going to be offered a £300 million package, however it is unclear whether the funding will be enough for the steel giant to make the necessary changes at its plant in Port Talbot, the UK's largest steelworks.
In August 2022, The Financial Times reported that Tata Steel threatened to shut down operations at Port Talbot if the UK government did not agree to £1.5 billion of subsidies to help it reduce carbon emissions. The report said that Tata has been in talks with the UK government about decarbonisation plans at the time, but discussions had stalled.
According to the BBC, the £300 million of funding being proposed to Tata may not be enough with the company estimating the cost of switching to "green steel-making" in Port Talbot at around £3 billion.
Tata produces around 3.6 million tonnes of steel a year in the UK and is responsible for around 2% of the UK's carbon emissions. One way for steelmakers to go green is by using hydrogen instead of coal, however for this to happen there first needs to be significant investment in the UK's hydrogen industry. An alternative is for British Steel and Tata to adopt electric arc furnaces which would be run using electricity provided by renewables.
https://www.bbc.co.uk/news/uk-64366998
https://www.hazardexonthenet.net/article/192564/Tata-Steel-invests--400-000-into-Port-Talbot-plant-to-reduce-emissions.aspx
Tata Steel Europe


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In his role, Brian Kowalchuk, AIA, LEED AP, Global Design Director, HDR, has elevated design excellence throughout HDR's culture, paying special attention to the humanistic, organizational and business issues of design. He has focused his career on spaces and environments that promote, advance and enhance discovery. Collaborating with world-leading research and teaching institutions, he has worked towards developing new paradigms that incorporate research, data and advanced technologies, as well as new ways of working that enhance efficiency, productivity and culture. His work has been honored with numerous AIA Awards, as well as seven prestigious R&D Magazine Laboratory of the Year Awards. Brian is a frequent guest speaker, panelist and design juror for various organizations including Tradeline, the Eagleson Institute, the International Association of Science Parks and R&D Magazine.


text:
Home News Werribee advocate calls for zero blood-alcohol limit
Werribee advocate calls for zero blood-alcohol limit
A Werribee road safety advocate whose brother was killed by a speeding drunk driver is urging Victoria Police to drop the state's legal blood-alcohol limit to zero to change motorists' attitudes towards drinking and driving.
Last week, police raised the possibility of lowering the legal limit from .05 to .02, asking the community to consider the benefits and impacts of such a move.
Lisa Markovic, whose brother Daniel was killed in May 2004, believes that dropping the limit to .02 is a step in the right direction, but she would like legislators to go even further and reduce it to zero.
"At .02, people will misjudge [how much they can drink] more than they do now," Ms Markovic said.
"If it is zero, there's no room for misjudgment.They'll know that if they're drinking they can't drive."
The co-founder of Road Trauma Families Victoria said it was time people thought more about the consequences of driving a car under the influence of alcohol.
She said drivers should never put themselves in the position where they might kill themselves or someone else.
"People have that misguided idea it's OK to get in the car after they have been drinking," Ms Markovic said.
"They don't see the big deal about what they're doing. People need to understand that alcohol and cars don't mix, regardless of how much you've had to drink.
"It's not just about being fined or losing your licence, the issue is that people die as a result of this behaviour and people are injured for life by this behaviour. At the end of the day, it is often innocent people who are affected and families are left to pick up the pieces."
Inspector Martin Boorman said police were considering lowering the blood-alcohol limit because at .05, a driver was at least twice as likely to be involved in a crash.
He said about 20 per cent of drivers killed on Victoria's roads had blood-alcohol concentrations over .05.
"It's about separating behaviours," he said. "If you're going to drink, don't drive. And if you are going to drive, don't drink."
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Mnet Refuses Seolhyun and Jimin's Request to Delete their history quiz scene
As you already know, AOA's Seolhyun and Jimin have embroiled in a controversy due to their lack of knowledge of history. In their reality program, "Channel AOA," the two idol star tried a history quiz but couldn't recognize Ahn Jung Geun, who was a famous Korean independence fighter. After the broadcast, a firestorm of criticism was directed at them.
Well, the public's outrage toward Seolhyun and Jimin is not just because they're ignorant about history. As I said above, Ahn Jung Geun was a Korean independence fighter and was a leader of the Korean independence movement against the Japanese occupation of Korea. He was executed by the Japanese government in 1909 for assassinating Ito Hirobumi, the Japanese administrator of power in Korea. You know, Japan's colonial rule and wartime aggression aren't appreciated by any Asian nation, and everything about Japan is always a very sensitive issue for Koreans. In the program, Jimin even addressed Ahn Jun Geun as "Kin To Kang," the Japanese way of pronouncing Korean name "Kim Doo Han" who is another historical figure. And people were very disappointed about Seolhyun because she is the ambassador of 2016-2018 Visit Korea Year.
By the way, there is a story behind the broadcast. After solving the history quiz, Seoulhyun and Jimin asked the production crew of "Channel AOA" to delete the scene. However, Mnet refused their request. Well, this is how Mnet does things. Audience rating is the most important thing for Mnet, and the broadcasting company never cares about cast members' human right and image. That's why Mnet's famous programs such as "Super Star K" and "Unpretty Rapstar" always cause controversy. I can't say Seolhyun and Jimin did a good job, but I'm sure at least half of Korean young people these days do not know about Ahn Jung Geun and Mnet needed to protect the two idol stars.
aoa Behind The News Columns controversy girl group jimin Offstage reality show seolhyun


Just like many Doppelgängers, Chraël-Här condisers other as its playtools, but some race suprisignly find some soft spot in his heart. Chraël has no clear memory of its genitors. His "Homeland" was mostly habitated by humans, lizardfolks and orcs. In its opinion, humans are naïve tools to use, lizardfolks are somewhat exotic and pretty in some kind of aquarium, and orcs are brutish, dumb, clearly not deserving the right to be honored by its presence.
Chraël soon had some contacts with Aphélisse, a nymph - or more specificly, the abandonned daughter of the Love Goddess - with who he shared common interests, like men, luxury and sometimes fashion. Because of this encounter, Chraël do like the presence of nymphs, althrough he sometimes belive most of them are dumb, "cute faces". The Anti-Paladin recieved some influence from Metweld, a friend Wizard Drow, from who he retains some hartred against elves. Soon devlopping a courtesan-like reputation with the Drow, they devlopped some kind of strange friendship, based on mutual help. Chraël-Här's Shape Changing abilities interested deeply the perverted Drow. Garrett Blackhood, a human rogue, didn't have this chance ; despite being forced to work together by the Great Kora, they always had some kind of rivality, and are often found backstabbing each other, at the Deity's despair.
Because of the brutish, and very conservator look upon their lives, Chraël-Här doesn't get along with dwarves. Neither does he get along with Halflings, but this is rather due to his bad habit to suggest they are cute, or forget that they don't like to be reminded they are small. In contrast, it gets along with Gnomes, with who he loves to play prank to other peoples. Especially Garrett.
5 ft./10 ft. 10 ft./5 ft.
Weapon and Armor Proficiency: Brimir is proficient with all simple and martial weapons, light armor, medium armor, and shields (except tower shields).
Fast Movement (Ex): Brimir's land speed is faster than the norm for his race by +10 feet. This benefit applies only when he is wearing no armor, light armor, or medium armor and not carrying a heavy load. Apply this bonus before modifying Brimir's speed because of any load carried or armor worn.
Illiteracy: Brimir does not know how to read and write.
Rage (Ex): Brimir can fly into a rage a certain number of times per day. In a rage, Brimir temporarily gains a +4 bonus to Strength, a +4 bonus to Constitution, and a +2 morale bonus on Will saves, but he takes a –2 penalty to Armor Class. The increase in Constitution increases Brimir's hit points by 2 points per level, but these hit points go away at the end of the rage when his Constitution score drops back to normal. (These extra hit points are not lost first the way temporary hit points are.) While raging, Brimir cannot use any Charisma-, Dexterity-, or Intelligence-based skills (except for Balance, Escape Artist, Intimidate, and Ride), the Concentration skill, or any abilities that require patience or concentration, nor can he cast spells or activate magic items that require a command word, a spell trigger (such as a wand), or spell completion (such as a scroll) to function. He can use any feat he has. A fit of rage lasts for a number of rounds equal to 3 + Brimir's (newly improved) Constitution modifier. Brimir may prematurely end his rage. At the end of the rage, Brimir loses the rage modifiers and restrictions and becomes fatigued (–2 penalty to Strength, –2 penalty to Dexterity, can't charge or run) for the duration of the current encounter.
Brimir can fly into a rage only once per encounter. Brimir can use this ability twice per day.
Uncanny Dodge (Ex): Brimir retains his Dexterity bonus to AC even if he is caught flat-footed or struck by an invisible attacker. However, he still loses his Dexterity bonus to AC if immobilized.
Trap Sense (Ex): Brimir gains a +2 bonus on Reflex saves made to avoid traps and a +1 dodge bonus to AC against attacks made by traps.
Improved Uncanny Dodge (Ex): Brimir can not be flanked. This defense denies a rogue the ability to sneak attack Brimir by flanking him, unless the attacker has at least four more rogue levels than Brimir has barbarian levels.
Damage Reduction (Ex): Brimir has Damage Reduction. Subtract 1 from the damage Brimir takes each time he is dealt damage from a weapon or a natural attack.
Low-Light Vision: Brimir can see twice as far as a human in starlight, moonlight, torchlight, and similar conditions of poor illumination. He retains the ability to distinguish color and detail under these conditions.
Weapon Familiarity: Brimir may treat dwarven waraxes and dwarven urgroshes as martial weapons, rather than exotic weapons.
Stability: Brimir gains a +4 bonus on ability checks made to resist being bull rushed or tripped when standing on the ground (but not when climbing, flying, riding, or otherwise not standing firmly on the ground).
+2 racial bonus on Heal, Knowledge (nature), and Survival checks: Brimir knows a great deal about what lives in the jungle, and ais adept at finding it (or avoiding it, as the case may be).
+2 racial bonus on Spot checks: Brimir has keen eyesight.
Alternate Form (Su): Brimir can shift into animal form as though using the polymorph spell on himself, though his gear is not affected (except for his magical breastplate that is made to change with the form), he does not regain hit points for changing form, and only the black bear can be what he shifts into. He does not assume the ability scores of the black bear, but instead adds the black bear's physical ability score modifiers to his own ability scores. Brimir also can assume a bipedal hybrid form with prehensile hands and animalistic features.
Changing to or from black bear or hybrid form is a standard action.
If slain, Brimir reverts to his dwarven form, although he remains dead. Separated body parts retain their animal form, however.
As a natural lycanthrope, Brimir has full control over this power.
Damage Reduction (Ex): Brimir in animal or hybrid form has damage reduction 10/silver.
Low-Light Vision (Ex): Brimir has low-light vision in any form.
Scent (Ex): Brimir has the scent ability in any form.


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ECTAD National Project Coordinator Vacancy at the Food and Agriculture Organization of the United Nations (FAO-UN)
Posted on: Sat 28-11-2020
The Food and Agriculture Organization of the United Nations (FAO-UN) - An intergovernmental organization, FAO has 194 Member Nations, two associate members and one member organization, the European Union. Its employees come from various cultural backgrounds and are experts in the multiple fields of activity FAO engages in. FAO's staff capacity allows it to support improved governance inter alia, generate, develop and adapt existing tools and guidelines and provide targeted governance support as a resource to country and regional level FAO offices. Headquartered in Rome, Italy, FAO is present in over 130 countries.
Job Title: ECTAD National Project Coordinator
Ref No: 2002748
Location: Nigeria-Abuja
Organizational Unit: FRNIR
Job Type: Non-staff opportunities
Type of Requisition: NPP (National Project Personnel)
Grade Level: N/A
Duration: 12 Months
Organizational Setting
The main aim of the FAO country office, which is headed by an FAO Representative (FAOR), is to assist government in developing policies, programmes and projects to achieve food security and to reduce hunger and malnutrition, to develop the agricultural, fisheries and forestry sectors, and to use their environmental and natural resources in a sustainable manner. In Nigeria, transboundary animal diseases (TADs) such as PPR, FMD and ASF, including zoonoses such as HPAI, EVD, Lassa Fever and other issues including AMR pose serious risk to agriculture and food/nutrition security especially in view of their impact on the livelihoods of smallholder livestock producers.
They also represent a persistent threat to the national, regional and global health security if not detected early and control on time. FAO had supported Nigeria to carry out several evaluations and develop a number of strategic documents and plans through a multisectoral/multidisciplinary approach with majority of the documents signed jointly by Ministries of Agriculture, Health and Environment: National Action Plan for AMR (2017); Joint External Evaluation (JEE) of the International Health Regulations (IHR) (2017); National Action Plan for Health Security - NAPHS (2018); National One Health Strategic Plan (2018); National Livestock Transformation Plan (2018) and OIE PVS (2019) follow up mission.
These evaluations and strategic documents have identified the gaps and priority actions needed to prevent, detect, and respond to public health threats. In the framework of Global Health Security Agenda (GHSA) Program in Nigeria, FAO Animal Production and Health (NSA)/Office of Emergencies and Resilience (OER) - Emergency Centre for Transboundary Animal Diseases (ECTAD) aims to support the National Veterinary Services to address these gaps in line with JEE recommendations.
The incumbent will work under the overall supervision of the FAO Representative in Nigeria in collaboration with Chief Veterinary Officer (CVO)/Chief, Animal Health Service (AGAH), the functional guidance of the Assistant FAO Representative (Programmes) on programmatic issues and country priorities, and the direct supervision and technical backstopping of the ECTAD Country Team Leader (ECTL) (or the Regional Manager of ECTAD for West and Central Africa in absence of the ECTL), and in collaboration with the ECTAD country team and RAF epidemiologist.
Technical Focus:
Support the implementation of FAO's Global Health Security Agenda (GHSA) Program at country level.
Tasks and Responsibilities
Advise the ECTL on technical decision matters and allocation of required resources for efficient implementation of the USAID supported EPT-2/GHSA country programme and other ECTAD projects
Act as ECTL in his/her absence. This includes planning and management of the ECTAD country team and technical and human resources needs in coordination with the Office of the FAO Representative to Nigeria and the ECTAD Manager for West and Central Africa.
Under the guidance and with support of the Assistant FAOR (Programme) and the ECTL, liaise with the Government of Nigeria, development partners, multi-lateral agencies and national and international non-governmental organizations, and the private sector in all matters related to high impact emerging and re-emerging zoonotic and non-zoonotic disease (rEIDs) prevention and control programme and related activities.
Participate in technical intersectoral meetings under the One Health framework with the major partners of the EPT-2/GHSA programme
In close collaboration with the ECTL and the Manager of ECTAD in West and Central Africa, advise the beneficiary government of country of assignment on any technical and policy matters related to high impact zoonotic and non-zoonotic transboundary animal diseases.
Contribute in the preparation of appropriate country strategies and programme for the management of rEIDs and other endemic Zoonotic and non-zoonotic disease, in close collaboration with the beneficiary government in line with the national policies, strategies and priorities, the FAO's Strategic Objectives, and the UNDAP II framework.
Assist in:
The preparation of project work plans, timely provision of inputs, organization of workshops, training programme, and liaison with responsible officers at national and sub-national levels for smooth coordination and delivery of FAO-implemented projects under the EPT-2 programme.
The smooth integration of the EPT2 programme activities and programme staff into the programmatic and administrative operations of the FAO Representation in the country of assignment; and contribute towards the development and implementation of the FAO country programme maintaining links with the established national networks on diagnosis and epidemiology to exchange and share technical information particularly related to priority and high impact animal diseases
The preparation and review briefs upon request from FAOR, ECTL
With the advice and support of the Assistant FAOR(Programme) and ECTL assist resource mobilization efforts, leveraging existing funds, to expand animal health related projects that are identified as priorities by the government of the country of assignment.
Conduct regular field missions in the country to monitor and ensure smooth implementation of the rEIDs related activities.
Contribute in the preparation of timely reports as required by the government, FAO and donors.
Contribute in providing regular updates of TADs epidemiology situation in the country as well as immediate notification to GLEWS of any significant epidemiological events
Submit a final technical report upon completion of the assignment to the FAOR and the ECTL
Perform other related duties as required.
Candidates will be assessed against the following:
Advanced university degree (Master's or PhD) in Veterinary Epidemiology, preferably with specialization in zoonoses control, control of infectious diseases in animals or related Emergency Management Disciplines; (candidates with Bachelors' degree in Veterinary Medicine with at least 5 years of direct experience in linked to GHSA Program at country level will be exceptionally considered)
Minimum of 3 years' experience in field veterinary epidemiology, surveillance, disease management or coordination programmes/platforms, including at least one-year experience linked to Government (Federal or State), UN System, organised private sector, multilateral institutions or international NGOs;
Working knowledge of English (level C);
National of Nigeria
FAO Core Competencies:
Results Focus
Building Effective Relationships
Knowledge Sharing and Continuous Improvement
Technical/Functional Skills:
Excellent organizational skills and a solid foundation in programme and project formulation, planning, implementation, management and evaluation;
Familiarity and experience with national animal health interventions linked to GSHA action packages: Zoonotic Diseases (ZDs); Biosecurity and Biosafety (BSS); National Laboratory Systems (NLS); Human Resources/Workforce Development (HR/WFD) and Antimicrobial resistance (AMR).
National Action Plan for Health Security (NAPHS); National One Health
Demonstrated ability to analyse problems, make appropriate recommendations and effective decisions, including in emergency settings;
Excellent written and oral communication skills in English, including the ability to present complex issues to FAO management and senior government representatives, as well as to non-specialist audiences;
Excellent written and spoken communication skills
Familiarity with Office tools including virtual/teleworking platforms
11th December, 2020.
Interested and qualified candidates should:
Additional Information and Notice
Please note that Closure Date and Time displayed above are based on date and time settings of your personal device
FAO seeks gender, geographical and linguistic diversity in order to best serve FAO Members in all regions.
Qualified female applicants are encouraged to apply.
People with disabilities are equally encouraged to apply.
All applications will be treated with the strictest confidentiality.
FAO does not charge a fee at any stage of the recruitment process (application, interview meeting, processing)
Incomplete applications will not be considered. If you need help please contact: [email protected]
Applications received after the closing date will not be accepted
Only language proficiency certificates from UN accredited external providers and/or FAO language official examinations (LPE, ILE, LRT) will be accepted as proof of the level of knowledge of languages indicated in the online applications
For additional employment opportunities visit the FAO employment website: http://www.fao.org/employment/home/en/
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Just like with iCalshare.com, for those of you who don't use this app you can also share calendar on iPhone 6 to others through via iCloud. On your personal calendar can only be seen by people who have iCloud accounts only, while General calendar can be shared by anyone with an Internet connection and a browser. Share your calendars, lets others know what you will do and can also give others the possibility to post events on your calendar.
Press the Calendar button at the bottom.
Press the red button on the right info if you want to share your calendar. If you want to create a new calendar, tap Edit → Add then tap done.
Type the name of the person that you choose to share your calendars or press the plus sign (+) to select people from your contacts.
Tap Add, then Edit Calendar and screen will appear and the names of people in your contacts will appear for you to select.
Tap View and Edit to edit or delete a calendar that you have been share with other people.
To find public calendars, press Edit Calendar to return to the previous screen and scroll to the bottom of the screen to find it.
Tap On to allow anyone to subscribe to a read-only version of your calendar.
You can send an e-mail or a message to the person that you want to invite to subscribe to this calendar, press the Share link to open share sheet.
And if you want to share your post in other places such as Twitter, Facebook, or your blog just have to copy the link and share it on social media that you want. Then tap done.
Those are a steps to share calendar on iPhone 6, you can find other iPhone 6 tips on another page.


Our core workshop for women provides an opportunity to enhance leadership abilities by capitalizing on shared experiences and by developing effective leadership skills for dynamic work environments.
Participants gain a clearer focus on personal goals while creating action plans that put skills and techniques into practical daily use. They refine their ability to think strategically and work collaboratively. The information they gain is compounded and amplified when they share it with others in their professional circles.
Women in this program are challenged to take charge of their lives and their circumstances by clearly articulating their individual wants, responsibilities, beliefs and values. This clarity becomes the basis for creating an actionable blueprint for personal and organizational success.
Unleash the true potential of people.
When I dare to be powerful – to use my strength in the service of my vision, then it becomes less and less important whether I am afraid.


This year, I've eagerly followed D C Thomson's longstanding title as it ambitiously embarked on a monthly tribute to the range of ordinary characters caught up in the extraordinary events of The Great War. The pocket sized Commando format is perfectly suited to these tales across the many theatres of war often highlighting lessor know combatants and conflicts. The stories are necessary stand-alone but, through cameos, contrast the idealistic enlistment dreams of a young newspaper boy with the experiences of those already at war. Although the tales are not the graphic accounts of a Charley's War or a White Death (see below), they are no less effective in bringing the stories of ordinary soldiers to a wider newsstand audience and that should be praised. Expertly written and illustrated by George Low and Keith Page behind exceptional new Ian Kennedy covers these are well worth seeking out and hopefully will be collected on the series conclusion.
Sticking with the First World War, this is the recent Image Comics re-release of the indie classic to tie in with the war's centenary. Set in 1916 on the Italian Trentino mountain range it is unflinching in its portrayal of those soldiers caught up in the desperation of war. The futility of conflict is expertly played out through the eyes of a small group of Italian soldiers as their struggles with the enemy and their nihilist commander are dwarfed by the dangerous mountain terrain. The quieter moments really stand out with carefully chosen dialogue and images reflecting the horror of the soldiers experiences without being preachy. Not an easy read for sure but an important one, well deserving of its hardcover re-release from two of the UK's leading talents.
An absolute delight and a charming contrast to not only First World War stories but all other comics I've encountered this year. An anthropomorphic pulp adventure full of mice, mystery and exotic locations, what's not to like! In the best adventure traditions, it's rollicking fun with an Indiana Jones vibe as our heroes meet by an (alternative) Egyptian archaeological dig where their finds are under dangerous threat from spies working for a mysterious benefactor. Matt Gibbs clever and quick moving script allows Sara Dunkerton plenty of opportunity to show off her artistic skills with many dynamic locations and action scenes. As a fun first issue from two new creators this promises to be the start of something special.
Honourable mentions to Letty Wilson's delightful WEIRD MOOSE which I witnessed being created at Glasgow Comic-Con, Top Shelf's authentic American Civil Rights Movement book, MARCH, Jonathan Cape's SALLY HEATHCOTE: SUFFRAGETTE, Images Comics entertaining MANIFEST DESTINY and enjoyable indies BLACK FEATHER FALLS and HALF HANGED MacNAGHTEN from Soaring Penguin and Uproar Comics respectively.


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California's Proposition 65 requires California consumers to be made aware of special warnings for products that contain chemicals known to the state of California to cause cancer and birth defects or other reproductive harm, if those products expose consumers to such chemicals above certain threshold levels.
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text:
rabble blogs are the personal pages of some of Canada's most insightful progressive activists and commentators. All opinions belong to the writer; however, writers are expected to adhere to our guidelines. We welcome new bloggers -- contact us for details.
Toronto media underestimating resilience and strength of Black Lives Matter leaders
It was supposed to have been the tweet stopped the earth from rotating. It was the tweet, twisted by mainstream media, that would make the city forget that on July 5, 2015 Andrew Loku a 45-year-old father of five with a history of mental illness was shot dead by Toronto police only minutes after arriving on the scene.
We were supposed to have forgotten that on September 24, 2014 Jermaine Anthony Carby was shot and killed by a Peel Regional Police officer in Brampton and neither of the officers involved will be charged with a crime. We were supposed to have overlooked names like Sophia Cook, Wade Lawson, Lester Donaldson and others who received what many in the Black community would described as an unjust and unnecessary level of violence via the barrel of a police officer's gun.
Finally, we should have not even been aware that Jean-Pierre Bony and Fredy Villanueva both unarmed Black or brown men were recently killed by the hands of police in Quebec. We were supposed to have turned our attention to the leaders of Black Lives Matter -- Toronto (BLMTO) and question their ability to lead as we fall in line. We were to believe that the leaders of BLMTO, while under the immense pressure that comes with constructing societal change, are somehow not permitted to pray for restraint as they press forward.
'Why are you doing this story?'
"Why are you doing this story?" said Sandy Hudson, co-founder of Black Lives Matter Toronto in an interview with veteran CP24 news reporter Jee-Yun Lee. Sandy Hudson was being interviewed about a tweet written by co-founder Yusra Khogali in February of this year.
Sandy Hudson went on to say that for two weeks people have been sleeping outside of the Toronto Police Headquarters under difficult circumstances protesting deaths in our community and just the day prior a Black man was killed by the hand of police in Montreal with not a single story from CP24. In addition Sandy stated that Premier Kathleen Wynne has committed to reviewing the Special Investigations Unit (SIU) and mainstream media is focusing on a story put forth from a man who has made homophobic, Islamophobic and misogynistic tweets in the past.
Sandy stated that he has effectively managed to manipulate media outlets to switch the story. She was referring to Jerry Agar, the Newstalk 1010 reporter, who discovered the tweet on Yusra Khogali's twitter account and broke the story.
Despite repeated attempts by veteran news reporter Jee-Yun Lee to get Sandy Hudson to switch the narrative from the police killings of Andrew Loku and Jermaine Anthony Carby. Even with the obvious frustration on the face of Jee-Yun Lee she was not able to move Sandy Hudson from the original narrative of the disproportionate levels of police violence against the Black community.
Was Sandy Hudson supposed to break down under the pressure of the veteran reporter? Was she supposed to run away crying taking with her the credibility of BLMTO? I don't have an answer to those questions but what I am confident of is that notwithstanding the young men on the executive of BLMTO on this day, mainstream media clearly underestimated the strength of the Black women who lead the BLMTO coalition.
A diamond in its earliest stages is under pressure as it is being formed in the earth. That pressure subsequently produces one of the strongest and most beautiful gems that the earth can provide. It has been said that in a similar manner, the pressure and adversity experienced in the lives of Black women produces some of the strongest and most beautiful gems that the Black community has to offer. That gem was what was displayed via Sandy Hudson during the CP24 interview.
As a community, we can never forget that when BLMTO recently set up camp outside of the Metro Toronto Police Headquarters. Protesting the SIU decision not to prosecute the officers involved in Andrew Loku's shooting or release their names. These Sisters and Brothers were beaten up by the police and dragged away from the barrels that safely housed the fires that kept them warm.
Both the barrels and their tents were taken by the police and they were left to protest exposed to the cold. In response, BLMTO acquired a sound system and a flatbed truck, organized a demonstration that brought hundreds if not thousands of people to the doorsteps of the police headquarters and draped a banner stating "Black Lives Matter -- Toronto" over the entrance to the iconic flagship Metro Toronto Police Headquarters.
In many ways the resilience and strength being displayed by BLMTO is comparable to the resilience of those who experienced firsthand segregation and discrimination in the southern United States. The greater the opposition to the end goal the stronger the resilience of BLMTO becomes.
Whether they are blocking Toronto's Allen Expressway, camping out at the Toronto Police Headquarters or engaging in some other creative form of protest in order to get the message heard. History will not soon forget the Sisters and Brothers of BLMTO who compelled a society to look at its own privilege and acknowledge that in addition to the other lives, all the Black lives matter as well.
Mark Brown is the Chair of the Toronto and York Region Labour Council's Equity Committee, a member of the Coalition of Black Trade Unionist (CBTU) and a member of the Toronto Local of the Canadian Union of Postal Workers.
toronto police
BLMTO
Yusra Khogali
Sandy Hudson


text:
Q: \Titleofalg with algorithm2e package The following code gives me an error and I am not sure why:
\documentclass{beamer}

\usepackage{default}
% typesetting of algorithms
\usepackage[vlined,linesnumbered]{algorithm2e}
\SetArgSty{textnormal}
\SetCommentSty{textnormal}

\begin{document}

\begin{frame}%{ % Implementation of pin() (((

  \frametitle{Implementation of \texttt{pin\,()}}

  \begin{function}[H]
    \Titleofalgo{ \texttt{pin($\mathit{pageno}$)}}
    \eIf
      {buffer pool already contains $\mathit{pageno}$}
      {$\texttt{pinCount\,(\(\mathit{pageno}\))} \leftarrow
           \texttt{pinCount\,(\(\mathit{pageno}\))} + 1$ \;
       \Return{address of frame holding $\mathit{pageno}$ \;}}
      {select a victim frame $v$ using the replacement policy \;
       \If{$\texttt{dirty\,(\(v\))}$}
          {write $v$ to disk \;}
       read page $\mathit{pageno}$ from disk into frame $v$ \;
       $\texttt{pinCount\,(\(\mathit{pageno}\))} \leftarrow 1$ \;
       $\texttt{dirty\,(\(\mathit{pageno}\))} \leftarrow \text{false}$ \;
       \Return{address of frame $v$} \;
      }
 \end{function}
\end{frame}

\end{document}

The error message I get is
./test.tex:31: Undefined control sequence.
\beamer@doifinframe ...{function}[H] \Titleofalgo
                                                  { \texttt {pin($\mathit {p...
l.31 \end{frame}

and I cannot figure out why. What am I missing please?

A: You forgot TeX is case-sensitive – the command is \TitleOfAlgo, and there is no default package – only a default theme for beamer:
\documentclass{beamer}

\usetheme{default}
% typesetting of algorithms
\usepackage[vlined,linesnumbered]{algorithm2e}
\SetArgSty{textnormal}
\SetCommentSty{textnormal}

\begin{document}

\begin{frame}%{ % Implementation of pin() (((

  \frametitle{Implementation of \texttt{pin\,()}}

  \begin{function}[H]
    \TitleOfAlgo{ \texttt{pin($\mathit{pageno}$)}}
    \eIf
      {buffer pool already contains $\mathit{pageno}$}
      {$\texttt{pinCount\,(\(\mathit{pageno}\))} \leftarrow
           \texttt{pinCount\,(\(\mathit{pageno}\))} + 1$ \;
       \Return{address of frame holding $\mathit{pageno}$ \;}}
      {select a victim frame $v$ using the replacement policy \;
       \If{$\texttt{dirty\,(\(v\))}$}
          {write $v$ to disk \;}
       read page $\mathit{pageno}$ from disk into frame $v$ \;
       $\texttt{pinCount\,(\(\mathit{pageno}\))} \leftarrow 1$ \;
       $\texttt{dirty\,(\(\mathit{pageno}\))} \leftarrow \text{false}$ \;
       \Return{address of frame $v$} \;
      }
 \end{function}
\end{frame}

\end{document}

A: Beware of the proper spelling; it's \TitleOfAlgo (T, O, A upper case) and not \Titleofalgo:
\documentclass{beamer}

\usepackage{default}
% typesetting of algorithms
\usepackage[vlined,linesnumbered]{algorithm2e}
\SetArgSty{textnormal}
\SetCommentSty{textnormal}

\begin{document}

\begin{frame}%{ % Implementation of pin() (((

  \frametitle{Implementation of \texttt{pin\,()}}

  \begin{function}[H]
    \TitleOfAlgo{\texttt{pin($\mathit{pageno}$)}}
    \eIf
      {buffer pool already contains $\mathit{pageno}$}
      {$\texttt{pinCount\,(\(\mathit{pageno}\))} \leftarrow
           \texttt{pinCount\,(\(\mathit{pageno}\))} + 1$ \;
       \Return{address of frame holding $\mathit{pageno}$ \;}}
      {select a victim frame $v$ using the replacement policy \;
       \If{$\texttt{dirty\,(\(v\))}$}
          {write $v$ to disk \;}
       read page $\mathit{pageno}$ from disk into frame $v$ \;
       $\texttt{pinCount\,(\(\mathit{pageno}\))} \leftarrow 1$ \;
       $\texttt{dirty\,(\(\mathit{pageno}\))} \leftarrow \text{false}$ \;
       \Return{address of frame $v$} \;
      }
 \end{function}
\end{frame}

\end{document}

The result:

I also suppressed an spurious blank space in the title.

redpajama_set_name: RedPajamaStackExchange


text:
Der Codex Mendoza ist eine aztektische Bilderhandschrift, die um das Jahr 1541/42 im Auftrag des Vizekönigs von Neuspanien, Antonio de Mendoza, für Karl V., den damaligen König von Spanien und Kaiser des Heiligen Römischen Reichs angefertigt wurde. Im Format 32,7 × 22,9 cm stellten auf 71 Seiten aztekische Schreiber die aztekische Geschichte von 1325 bis 1521, Tributzahlungen und das Leben der Azteken in ihrem autochthonen Schriftsystem dar, ergänzt durch spanische Übersetzungen, Kommentare und Erweiterungen.

Geschichte
Im Jahr 1542 wurde die Handschrift zwar nach Spanien geschickt, gelangte aber durch Piraten zunächst nach Frankreich, wo der französische Mönch und Reisende André Thevet (1502–1590) in seiner Kosmografie darauf Bezug nahm. Sie befindet sich seit 1659 im Besitz der Bodleian Library in Oxford (Signatur MS. Arch. Selden. A. 1).

Inhalt
Der Codex Mendoza enthält wichtige Informationen über die Herkunft, die Kriege, die Kindeserziehung und den Glauben der Azteken. Auf der Bildschrift, die die Gründungslegende von Tenochtitlán darstellt, ist ein Adler zu sehen, der sich auf einem Kaktus niederlässt und im Schnabel ein gelbes und ein rotes Band, die aztekischen Wortbilder für "Rauch" und "Flammen", als Symbol für den Krieg trägt. In späteren Überlieferungen hält der Adler eine Schlange in seinen Krallen (Aubin-Codex (1576), Fernando Alvarez Tezozómocs Cronica Mexicana (1598)), wie er noch heute das Wappen und die Flagge Mexikos ziert.

Der Codex zeigt, dass die Azteken den Akt des Sprechens durch ein Luftwölkchen symbolisierten, ähnlich den Sprechblasen der Comics.

Ausgaben
 James Cooper Clark (Hrsg.): Codex Mendoza, the Mexican manuscript known as the Collection of Mendoza and preserved in the Bodleian library, Oxford. 3 Bde., Waterlow, London 1938
 Kurt Ross (Hrsg.): Codex Mendoza: aztekische Handschrift. Parkland, Stuttgart 1978, ISBN 3-88059-123-7
 Frances F. Berdan: The Codex Mendoza. 4 Bde. Berkeley [u. a.]: Univ. of Calif. Pr. 1992 ISBN 0-520-06234-5
 Bd. 1: Interpretation of Codex Mendoza
 Bd. 2: Description of Codex Mendoza
 Bd. 3: A facsimile reproduction of Codex Mendoza
 Bd. 4: Pictorial parallel image replicas of Codex Mendoza
 Stefan Rinke, Federico Navarrete, Nino Vallen (Hrsg.): Der Codex Mendoza. Das Meisterwerk aztekisch-spanischer Buchkultur. wbg Edition, Darmstadt 2021, ISBN 978-3-534-27355-3

Literatur
 Patricia Rieff Anawalt / Frances F. Berdan: Der Codex Mendoza, in: Spektrum der Wissenschaft, Oktober 1992, S. 68–81
 Ulla Karla Schmid: Die Tributeinnahmen der Azteken nach dem Codex Mendoza. R. G. Fischer, Frankfurt (Main) 1988, ISBN 3-88323-777-9

Weblinks

 Digitalisat
 Inhalt und Beschreibung des Codex Mendoza

Einzelnachweise

Azteken
Bilderhandschrift (16. Jahrhundert)
Handschrift der Bodleian Library (Oxford)

redpajama_set_name: RedPajamaWikipedia


text:
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Home » Games » Action Games » The Adventure Pals
Keith Harris July 18, 2018 11 0
The Adventure Pals is a side-scroller action game with RPG elements. It has been developed by Massive Monster Studios and was released on April 3, 2018. The Adventure Pals takes players on a crazy journey through many weird regions, some of which may contain zombie pirate cats, dinosaurs, and explosive dogs.
Download The Adventure Pals
To download The Adventure Pals click on the Download button. It can be found towards the end of this review. You can download the game from many platforms such GOG.com, Microsoft Store or from Steam. The Adventure Pals is available for Windows, macOs, PS4, Nintendo Switch and Xbox One.
The Game Review
The cartoon theme of the game is reminiscent of the once popular Cartoon Network series The Marvelous Misadventures of Flapjack. The crazy things that go on in the game's world are also reflective of what happens in the cartoon series as well. While not related directly whatsoever, I would like to say it can be considered a "low-key" homage to the series. In the crazy world, players are fighting and chasing the evil antagonist, "Mr. B," that is kidnapping old people and turning them into hot dogs.
You call to arms your best buddies, Sparkles the Giraffe and Mr. Rock, to fight and travel alongside you, characters I'll get into a bit later. With your crew, take on enemies in platform-based zones while using all sorts of tools and weapons to destroy everything that stands between you and Mr. B.
But beyond just traveling to fight the antagonist, the world offers so much more to do almost like an open world where you can take on plenty of side quests. More specifically, there are 5 distinct worlds up for exploration. The game continues its "nonsense comedy" in the game by letting you unlock new outfits by finding cupcakes and finding stickers to fill out a scrapbook. The game also features a co-op to take a buddy along with you for double the fun. The developers like to describe the game as "your favorite peanut butter and jelly sandwich." The game also progresses itself to be more challenging as you continue on to keep you on your toes. The game is a wonderful throwback to all the ridiculous cartoons we had back in the day and does not fail to keep you entertained throughout.
Coming back to our game's protagonists, first is you, the player. When it's supposed to be your birthday, all you get is your good ol' Pops taken away and it's your duty to bring him back. Do all the deeds this crazy world needs you for in order to save your Pops in time and before Mr. B gets away. Next is your Giraffe friend who also happens to be a philosopher and a MENSA member, for those naturally gifted. Despite the gifted resume, Sparkles is as crazy as they come with a helicopter-like tongue, long neck for escapes, and to help you jump higher. She is basically the greatest utility friend ever, or in other words, friends with benefits.
As for Mr. Rock, he's just a rock. Well, I wouldn't want to spoil everything for you but for now, let's just say he's a rock. Overall, the game's characters and lore are very well thought out regardless of the ridiculous theme. For those familiar, imagine BattleBlock Theater but as something more than just a platformer.
The Adventure Pals is a platform game in which you have to do a lot of monsters killing. Download it and accept the quest to thwart the plans of Mr. B.
User Rating: Be the first one!
Massive Monster
www.theadventurepals.com
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NEW ORLEANS–(BUSINESS WIRE)–Kahn Swick & Foti, LLC ("KSF") and KSF partner, the former Attorney General of Louisiana, Charles C. Foti, Jr., remind investors with large financial interests that they have only until September 9, 2019 to file lead plaintiff applications in securities class action lawsuits against CannTrust Holdings, Inc. (NYSE: CTST). Investor losses must relate…
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NEW YORK–(BUSINESS WIRE)–LB Equity, an investment firm focused on emerging brands in the beauty and personal care sectors, today announced an investment in Herb Essentials, a holistic, cannabis-centric, lifestyle beauty brand founded by Robert Lund and Ulrika Karlberg in 2015. In partnership with LB Equity, Herb Essentials will look to expand its product assortment, with…
TILT Holdings Announces Milestone of Supporting 2,000 Brands Across North America and Full Integration of Baker into Blackbird
CAMBRIDGE, Mass.–(BUSINESS WIRE)–TILT Holdings Inc. ("TILT" or the "Company") (CSE: TILT) (OTCMKTS: SVVTF), a foundational technology cannabis platform comprised of assets to support brands worldwide, announced today it has reached a milestone of supporting 2,000 brands across North America between three of its subsidiaries: Jupiter Research, LLC ("Jupiter"), Baker Technologies Inc. ("Baker") and Blackbird Logistics…
Edison Nation Announces the Launch of Products Under Their New Health and Wellness Brand – Sol & Salud
PHILLIPSBURG, N.J.–(BUSINESS WIRE)–Edison Nation, Inc., a multifaceted ecosystem which fosters innovation and drives IP, media and consumer products today announced that they will be entering the health and wellness industry with their new brand Sol & Salud. Sol & Salud embraces balancing the mind and body to achieve maximum health through its range of products.…
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