Campus Housing Environment - Campus Management, Inc.
The Campus Housing Environment - We believe that, if you spend the time to read and understand this page, you will be among the most informed house/apartment shoppers on campus this year. Additionally, you'll know what to expect when working with our rental agent to find the housing that best suits your needs! So read on and call us with any questions you have!
Anyone reading this page probably realizes that the University of Michigan / Ann Arbor rental market is very competitive and fast paced. People who will be new to the campus community should know that the peak rental season begins in mid October and runs strong until students leave for spring break at the end of February. The house and apartment shopping that goes on during this period is for leases that will start the first day of September of the next academic year. So leases are commonly signed 8-10 months prior to move-in. Recently accepted students who view this page in late Spring or Summer should be aware that by the beginning of Summer many local management companies will be 90 to 100% leased for the fall. People who find themselves shopping for housing in the summer should be prepared to hustle to get the best of the last available rentals. We have about 200 student oriented houses and apartments within 10 blocks of campus. They range from efficiency apartments to six bedroom houses.
It is very important that you be on time to the appointment. You should see our rental agent within five minutes of your appointment time. Our appointments are scheduled on 15 or 30 minute intervals so we occasionally run a few minutes late.
We generally have a lot of ground to cover during a brief appointment so be prepared to keep a quick pace and ask questions while the tour progresses.
If you arrive late we may be forced to delete some of the rental units you hoped to see from the tour.
You may, of course schedule another showing if for some reason we can't show you something at our first scheduled appointment.
If, for a 30 minute appointment, the rental agent waits 15 minutes beyond our scheduled appointment and no prospective tenant has arrived for the appointment our rental agent will leave the agreed meeting place in order to be on time to the next scheduled appointment (for a 15 minute appointment we will wait 5 minutes).
If you cannot keep your scheduled appointment we would truly appreciate a phone call; it may prevent our rental agent from making an unnecessary trip across town.
Make sure that as many people as is possible attend the showing. With rentals going fast you have an advantage if the group can reach consensus while you're at the rental property.
Know your budget! It makes no sense for you to look at housing your group can't afford and wouldn't truly consider renting.
If you see something you like be prepared to act quickly. We have seen days when six or seven houses rent on the same day! Don't let something you really like get away because your group wasn't ready to act. With this in mind, talk to all concerned parties about your plans before you begin shopping so that they're on board for what you plan to do. Understand the budgets and concerns of roommates. Their objectives may not be exactly the same as yours. Knowing this will help further focus the search on appropriate units.
Ask a lot of questions! During the showing the rental agent will walk you through the house and answer any questions you may have. We encourage you to be active participants in this process. We have seldom heard bad questions and asking question avoids confusion down the road. So keep our rental staff on their toes and ask a lot of good questions. Some common topics that raise questions at the showing are: rent, security deposit, utilities, parking, trash removal, snow removal, lawn care and maintenance. If something doesn't get answered at the rental showing don't worry. You can call our rental office or e-mail us with any question you have. If you e-mail questions we'll get back to you as quickly as we can.
Our houses and apartments are available on a first come, first served basis. Without exception, fully completed applications are considered in the order they have been submitted to us. Applications are not taken at showings. Applications are completed and submitted at our rental office (Campus Management, Inc. 337 E. Huron St., Ann Arbor, MI). Unfortunately, in our fast paced rental market this does occasionally create footraces between groups vying to get back to our office first. Applications are considered complete when they have a number of names and signatures appropriate to the size of the rental unit for which the application is being submitted, and then only when they have been submitted with a check for the first 1/3 of the security deposit. If time passes between your showing and your decision to proceed please call the office to verify that the house or apartment is still available. It may have already been rented.
Before you complete an application you should understand how it commits you. Probably 99% of our applications are accepted and conclude with signed leases. If for some reason you change your mind after submitting a completed application you should know in advance that an amount equal to a half-month's rent is non-refundable. The reason for this is that, once an application is submitted for a specific property, the property is withdrawn from our literature and our website. The property is held in your name and is not shown to any other prospective residents. In the event of a cancellation we generally lose at least a week of time we could have been showing that property to other well organized groups. That loss of time has a definite cost associated with it, hence the loss of half of a month's rent. We suggest to people that they should not submit a completed application (with payment) unless they are certain that they want to live in the subject property.
Campus Management, Inc. requires the payment of a cleaning fee. Your application will include a charge for a cleaning fee. The size of this fee is based on the number of bedrooms in the subject house or apartment. Please see the table below.
Another important subject involves co-signatures. Some Campus Management, Inc. properties require a co-signature from a qualified co-signer when the applicant lacks full-time employment. The purpose of the co-signature is to guarantee payment in the event the applicant cannot or does not pay. Where groups of unrelated tenants will live together under one lease a co-signer may specify that he/she is only assuming responsibility for their party's fraction of the rent; this may be done by noting so underneath the co-signature.
An application is only complete when the completed application and deposit are delivered to Campus Management, Inc. Our rental agents will make no verbal promises to hold units or to call your group if other groups "seem interested." These promises betray our system of fairness and we simply don't make them.
All of the basic information pertaining to the lease (e.g. term, installment rent, parking and utility arrangements) is contained on the application. The application acknowledges that no other verbal promises have been made. If you've discussed details about the house or apartment that you are relying on make sure that they are captured in writing on the application.
Make sure that you clearly understand the parking situation at the property you want to rent.
Review the application and make certain that you understand which utilities are your responsibility to pay and which ones are included in the rental payment.
If you are required to pay for heat in your rental unit you will be given a copy of a"Heat Cost Disclosure" form which discloses the past year's monthly average fuel cost for heat. We will also ask you to sign a copy of this form for us to retain in your lease file. This estimate gives some evidence as to what you should expect to pay for heat. Remember the heating habits of the prior tenant are reflected in the estimate; your actual usage will probably vary from the estimate. CMI cannot be responsible for any variance from this estimate.
You should understand the lease dates and how they affect you. Our leases for the next academic year begin at noon on Friday, September 1, 2017 and run until 11:59 PM on Friday, August 17, 2018. We are able to move a limited number of units in early each year. These Early Move-Ins are available for a fee. The early move-ins are limited to several pre-determined days in late August. Prices vary depending on the size of the unit and the move-in date. Please see the table below for prices and dates.
No holdover occupancy is allowed. We are unable to grant any extensions to leases. The last day of the lease is the last day of the lease without exception. We are on a very tight timetable to turn over our units each year and need every day we've contracted for to accomplish our painting, cleaning and maintenance.
Special arrangements are provided to those transferring from one CMI managed unit to another. We allow transferring residents to lay over at their current rentals until their new unit is prepped. All 2017 transfers will be done on the afternoon of August 23, 2017. Keys to new units must be picked up at our office between 3:00 PM and 5:00 PM on the 24th. Keys to old units must be returned to CMI offices by 8:30 AM on August 24, 2017. Failure to pick-up/return keys as described here-in will result in "Holdover" occupancy charges - review your lease.
1/3 of the total Security Deposit. Nonrefundable if the lease is not executed.
Due October 1, 2017. Note that prepaying your Sept. 2017 installment means that no installment is due on move-in day.
We use EchoSign for lease execution via the internet. You must execute your lease digitally within 72 hours of receiving the Echosign e-mail indicating that the lease is ready for signature. Failure to sign within this time frame can result in the rental of the house or apartment to another group. Read your contract to know when the balance of your security deposit and cleaning fee are due. Echosign also processes Financial Co-guarantors signatures where those are required. Once every resident and every required financial co-guarantor has digitally signed the lease EchoSign will automatically provide each party with an executed copy of the lease document.
Note: Without exception, all student leases expire at 11:59 PM on Friday, August 18, 2017.
8/19/17 – Saturday: CMI office open for key drop and rental inquiries only from 10 AM to 2 PM.
Note: Rental Agent may be available for showings by appointment outside of these times.
Note: Rental Agent may be available for pre-arranged showings of un-rented housing.
Phones are not answered from noon to 1 PM daily on these days.
8/23/17 is moving day for transferring residents. Transfers, pick-up keys between 3:00 PM and 5:00 PM. Old keys must be returned by 8:30 AM on8/24/17 to avoid holdover fees.
Rental Agent may be available for scheduled showings outside of these times. Please call us to schedule a showing – our schedule is flexible.
Note: Rental Agent will be available to show apartments. Rental Agent may be available for pre-arranged showings of un-rented housing.
People holding properly executed Early Move-In Contracts for 8/29/17 may pick-up keys beginning at 4 pm on the 29th.
9/1/16 - Friday 2017 Student Move-In Day: CMI offices open 9:00 AM to 5:00 PM. We will begin moving people in at 10:00 AM.
Expect 5 to 15 minute wait to meet with CMI agent and begin Move-in procedure.
First Month's Rent must be paid in full or keys will not be released.
Depending on status of our rentals our Rental Agent may be available by phone. Please call 663-4101 to leave a voice message. If available, the Rental Agent will return your call.
Our Emergency Maintenance Notification System is always available. This service is available to those with legitimate and urgent health and safety emergencies. For example, Regular maintenance issues, furniture adjustments, parking issues or internet problems will not be addressed outside of our normal office hours. Call us at (734) 662-7787 and follow the prompts to leave a message in our emergency mailbox.
Your Lease will begin at noon on September 1, 2017 unless you have purchased and signed a Early Move-In agreement from Campus Management, Inc. Move-in Day is our busiest day of the year. You may have to wait to meet with one of our move-in representatives. The typical wait is less than 10 minutes. You must come to our office to pick-up keys. At move-in we will meet for about 10 to 15 minutes to review the move-in process with you. In addition to keys, you will be given a move-in packet with important information concerning your new home. We will review parking (if provided), utilities, maintenance and other related topics. Do not expect to dash-in, grab keys and dash out; the move-in process helps insure that we start out correctly. Instead, plan a list of any move-in questions you wish to ask us. We look forward to a smooth move-in and to serving your needs beyond move-in day.
IF YOU FAIL TO PICK UP KEYS FOR YOUR UNIT BY THE TIME WE CLOSE ON MOVE-IN DAY YOU WILL NOT BE ABLE TO MOVE-IN UNTIL THE DAY AFTER LABOR DAY - MAKE AND STICK TO A SCHEDULE THAT GETS YOU INTO OUR OFFICES BY 5:00 PM ON MOVE-IN DAY!


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Pakistan International Flight 661 Crashes While Enroute to Islamabad
December 7, 2016 Matthew Garcia Airlines
PIA ATR 42-500 (Photo: By Asuspine [GFDL 1.2 (http://www.gnu.org/licenses/old-licenses/fdl-1.2.html) or GFDL 1.2 (http://www.gnu.org/licenses/old-licenses/fdl-1.2.html)], via Wikimedia Commons)
On Dec. 7, 2016 at 4:42PM local time, Pakistan International Airlines flight 661 vanished from the radar on its flight from Chitral to Islamabad. The flight, an ATR-42-500, was carrying 42 passengers and six crew members when it crashed outside of the town of Havelian. The flight departed Chitral around 3:30PM local time and crashed into a mountain side roughly an hour later.
Initial reports state that the aircraft suffered an engine failure on the left Pratt & Whitney 127E engine. The pilots shut down the engine and continued their descent. A few minutes later, the pilots declared Mayday. Radio and radar contact were lost around 11:30Z. A PIA spokesman Danyal Gilani, confirmed that, out of the 48 people on board, there were no survivors.
CAA spokesman Pervez George reported, "I don't think there is any chance of finding any survivors."
The Army in Pakistan has thus far reported 36 bodies being recovered. Among the passengers were 31 men, 9 women, and 2 infants. Passengers included Junaid Jamshed, a pop singer who turned Islamic preacher, Deputy Commissioner Chitral Osama Warraich, and a PIA ground engineer. The Pakistani Civil Aviation Authority, PIA, along with the country's military, are deploying resources to the crash site as well to Islamabad airport to help family members of those that were lost.
The aircraft black boxes have been recovered and are currently being reviewed by Pakistan's Civil Aviation Authority. Witnesses reported finding aircraft parts and bodies being burned beyond recognition. The crash site was reported to be burning for hours after the crash at responders fought the fire and recovered bodies. According to Havelian police official Kurshid Tanoli, emergency vehicles "can only go to Batolani and then it is a 30-minute walk" to the crash site. Government officials have stated they will continue to focus on helping the national air carrier who has been struggling financially.
Today marks the second deadliest crash in the country's history, with the most severe crash in Pakistan occurring in 2010 when a privately owned Airbus A321 crashed near Islamabad while on approach. All 152 passengers on board were killed. The last major aviation crash in Pakistan occurred last year, involving a military helicopter that crashed in a northern valley killing eight people.
Matthew Garcia
Matthew Garcia became interested in aviation at the age of 12 when he installed Microsoft Flight Simulator X on his computer. He was instantly "bitten by the bug" and has been in love with aviation ever since. Matthew took his first introductory flight in 2013 and began normal flight training in February of 2015. Over the years, Matthew's love and knowledge for aviation has grown tremendously, mainly due to FSX. Garcia flies highly advanced aircraft in a professional manner on a highly complex virtual air traffic network simulating real world flying. In 2016 Matthew achieved his private pilot certificate from the FAA. Now he studies journalism at the University of Nebraska at Omaha.
Latest posts by Matthew Garcia (see all)
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Boeing Announces MAX Production Cut, Creates Committee to Re-Evaluate Company Policies - April 6, 2019
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PIA661
United Launches New Amenity Kits and Changes to Catering
February 24, 2016 Tyler Tashji
United to Add Boeing 777-300ER Flight Schedules This Weekend
December 9, 2016 Ryan Ewing
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July 28, 2018 Joe Pesek
The World's First 747-400 To Fly Last Revenue Flight, Leaving a Legacy Behind
TBT (Throwback Thursday) in Aviation History: Atlantic Southeast Airlines
Things Aviation Administration Majors Hear
Airline Metrics: Revenue Passenger Kilometers
Cybersecurity's Importance in Aviation Highlighted During SXSW

redpajama_set_name: RedPajamaCommonCrawl


Sheet Metal Work Directory in United States. Are you looking for Sheet Metal Work Company in United States? you are at the right place.
Find Companies in Sheet Metal Work Business Directory of United States with offers and solutions. Here is the list of companies offering Sheet Metal Work Service in United States with contact person, phone number, email, address, reviews and contact details.


6-830pm on Tuesday, April 24th.
Admission is $12 MMoA members; $15 non-members; $3, children ages 4-12; and, free for children three and under. Season passes are also available: $60 MMoA members; $75 non-members.
Sponsors: ABC PhotoLab, Captain Daniel Packer Inne, CMB Creative Group, Coca-Cola, Cottrell Brewing, H&H Distributing, Hosmer Mountain Beverages, Mystic Shipyard, Mystic River Mudheads Sailing Association, Noank Village Boatyard, Pizzetta, Sails Up 4 Cancer, The Real McCoy; Malloves Jewelers; Mighty Swell Beverages.


Image 7-1/2" x 13-3/4" - Edition 50 signed and numbered prints, 15 remarqued artist proofs.
This is one of my early watercolors experimenting with glazing. Godiva was inspired from a dream which included a transparent horse. The horse was painted separately, "The Welcome Stranger" and was my first truly glazed watercolor.


In this article I'll pose the question whether the problem is that people (or executives or both) don't know what risk is or choose to ignore it. We will see what the implications of either and/or both are.
(Lane Wallace, Why We're So Bad at Managing Risk, 2010).
In the same article Lane goes on to talk about the catastrophic oil spill in the gulf. She points out that BP is not new to offshore operations or the risks inherent in drilling into the earth. Lane asks the question "how did the company misjudge the dangers, risk and consequences of an accident so badly?" Herein lies the crux of it. Financial return will trump any and every other concern.
Leaving the stark reality of the Deepwater Horizon oil spill, the Challenger space shuttle accident and the emotive discussion on where the blame lies. Let's have a conversation about the industry we all work in, an industry where technology and people co-exist and collaborate for commercial reasons.
Substituting risk management failures for NASA and BP disasters I want to know how we keep getting it so wrong… so often? My assertion is that Lane Wallace thinks the easy answer is, there's a financial incentive for going forward, and a financial disincentive for holding back. Is that it? Does it all come down to money at the end of the day, no matter what the consequences? Or is it more nuanced?
Lane Wallace points out that "risk is an elusive, and ultimately unconquerable, opponent." That said Lane advises to "expect the unexpected. And plan accordingly." Expect the unexpected. And plan accordingly. We don't. Why? Richard Leblanc presents the reasons. "I have never encountered a risk management failure where the board was not at fault, based on what the board said or did, or failed to say or do." The three wise monkeys strain of the C-ostrich, Do-ostrich disease has reached epidemic proportions. Is it, like risk, an ultimately unconquerable opponent?
I'll leave you with this question? When is the next Deepwater Horizon oil spill or the Challenger space shuttle accident going to happen? Place your chips. Roll the dice. It's Vegas baby!
Please read Richard's article (http://corporatecomplianceinsights.com/25-reasons-for-risk-management-failure/) to see the full list. It's insightful and frighteningly familiar.


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Trending publication
Landlords in the Midst of a Pandemic, Worried about that Work Letter Deadline?
03.13.2020 | Legal Advisory
Facing the escalating crisis of the COVID-19 outbreak, commercial landlords building out space for tenants are likely concerned about completing their projects on time. Many leases provide tenants with day-for-day rental abatements if the landlord's work obligations are not completed before the targeted completion date. In addition, although less common, some leases provide a tenant with the right to terminate a lease due to delays to complete work.
COVID-19 is introducing the risk of widespread contractual delays that months ago would not have been foreseeable and which thrust the concepts of force majeure and the common law doctrines of impracticability, impossibility and frustration of purpose into the limelight. Although seldom litigated, understanding how force majeure and these other common law doctrines function is helpful in confronting delays in existing leases and negotiating new leases.
Force Majeure and Common Law Protections for Landlord Delays
Force majeure clauses evolved from the common law doctrines of impracticability, impossibility and frustration of purpose. In general, the common law doctrines excuse a party's performance under a contract if an event occurs that is beyond a party's control. The doctrine of impracticability is an offshoot of the doctrine of impossibility, and for purposes of this article, discussion of both doctrines will be combined and discussed as the doctrine of impracticability. Although the common law provisions provide some protections, they are not available defenses to performance if the contract at issue contains a force majeure clause.
Impracticability excuses contractual performance when a supervening event renders a party's performance so excessively burdensome that performance is excused. Frustration of purpose, on the other hand, excuses performance when a supervening event occurs that renders performance worthless to the other party. For both impracticability and frustration of purpose, jurisdictions are split whether the supervening event needs to have been unforeseeable to excuse performance.
Force majeure clauses function in the same vein as the common law doctrines. When confronting delays, a force majeure clause will best serve a landlord if the cause for the delay at hand is specifically identified. In some instances, a force majeure clause may be more limiting than the common law doctrines. For example, courts generally hold that a force majeure clause with a limited subset of triggering events will exclude those events that are not explicitly identified. Courts, though, look favorably on broad language that includes events outside of a party's control.
COVID-19 and Landlord Work Delays
Using delays caused by COVID-19 as an example, a landlord's work obligations under a lease could be delayed for several reasons. On the macro level, a region-wide quarantine, similar to measures taken in Italy or Hubei province, could halt all construction. On a more micro level, a laborer becoming ill could lead to a work stoppage for the crew working on a specific project. Either situation could ruin a schedule, and absent protections from a force majeure clause or the common law doctrines, expose the landlord to ever-increasing rent abatement costs or lease termination.
A landlord facing these delays should prepare in advance for the possibility of missing a deadline. As an initial step, the landlord should conduct a thorough review of the lease and become familiar with the provisions governing its work obligations. Are there monetary impacts for missing a deadline? Does the tenant have a right to terminate the lease for late delivery? Also, the landlord should review the lease's force majeure clause to see whether it includes pandemics, government action or a broad catch-all provision. If the lease has a force majeure clause without a broad catch-all, the landlord will only be protected if the delay can fit within one of the identified reasons for force majeure. In addition, the force majeure clause may require that the landlord give notice within some period after the event causing the force majeure. Missing the notice deadline could have a devastating financial impact on the landlord.
Again, all is not lost if the lease does not contain a force majeure clause. The common law doctrine of impracticability would, in all likelihood, be available to a landlord whose construction project grinds to a halt due to the COVID-19 outbreak.
This advisory was prepared by Christopher W. Papavasiliou and Michael Cavoto, in Nutter's Real Estate Department. If you have questions about how COVID-19 may affect your case, please reach out to your Nutter attorney at 617.439.2000.
This update is for information purposes only and should not be construed as legal advice on any specific facts or circumstances. Under the rules of the Supreme Judicial Court of Massachusetts, this material may be considered as advertising.
More Publications >
Christopher Papavasiliou


Bookmark this Lesson. Today's lesson is going to cover the acoustic version of Lynyrd Skynyrd's "Simple Man" as played by Shinedown.
This acoustic version of Simple Man has some nice arpeggiated picking used throughout the verse. That picking uses a basic pattern that is repeated lot so it shouldn't take you very long to get a good grasp of the song.
The chords are very simple and pretty much stay the same through both the verse and chorus.
This Simple Man guitar lesson will show you how to play every section of the song note-for-note including the little lead fills added throughout the song.
Keep in mind that as I mention in the video lesson, I am basing this lesson off of the acoustic live version you will see Shinedown do. There are many recordings and YouTube videos showing them performing this version of Simple Man live.
When this lesson was originally requested it was for me to demonstrate this live version. I usually stick with the original studio recorded versions of songs for my lessons, but after listening to Shinedown's live version I agreed that the live guitar parts were much more interesting.
In any case, this lesson should get you playing this nice acoustic ballad in no time.
Thanks Carl! A different version to a popular song, the other versions can be found all over the web, but this version is the most interesting to play on the acoustic. Why is everyone not a member here, Carl listens to his members requests and is the best teacher out there online.
DITTO! I have such a connection with this song and many more that Carl chooses to share with us! Thanks Carl for being there to help me reconnect with one of my almost lost (but no longer!) passions (guitar),, and your being such a great teacher!
I to enjoyed the lesson …hope you could help me with the song suite madam blue..please.
This is an amazing cover of this great song! I learned the original back in 1978 because from the first time I heard it I was hooked. Thank you for this version Carl. You have great taste. I also would like to see a Styx song or two.
Thank you for sharing the lesson on how to play this song.
Where can I get the tab for this song?
I've seen others on the Internet but don't agree with them .


March 05, 2019 16:03 ET | Source: Kura Oncology, Inc.
SAN DIEGO, March 05, 2019 (GLOBE NEWSWIRE) -- Kura Oncology, Inc. (Nasdaq: KURA), a clinical-stage biopharmaceutical company committed to realizing the promise of precision medicines for the treatment of cancer, today reported fourth quarter and full year 2018 financial results and provided a corporate update.
New findings for tipifarnib in pancreatic cancer – In January 2019, Kura presented new findings at the 2019 Gastrointestinal Cancers Symposium identifying a potential association between CXCL12 expression and clinical benefit in patients with pancreatic cancer treated with tipifarnib. Elevated CXCL12 expression is known to be a poor prognostic factor in patients with certain solid tumors, including pancreatic cancer. The Company is currently working with key opinion leaders and investigators on the design of a proof-of-concept trial in this indication.
Validation of CXCL12 as a therapeutic target of tipifarnib in PTCL – In December 2018, Kura reported an association between CXCL12 expression and clinical benefit in the Phase 2 trial of tipifarnib in relapsed or refractory PTCL at the American Society of Hematology (ASH) Annual Meeting. Specifically, patients with a high ratio of expression of CXCL12 to its receptor CXCR4 experienced a 50% objective response rate (five of 10 with either complete response or partial response) and a 90% clinical benefit rate (nine of 10, including stable disease) with tipifarnib. Patients in the Phase 2 trial were heavily pretreated, with a median of three prior lines of therapy (range 1-7).
Proof-of-concept in AITL – Kura also reported preliminary data from its Phase 2 clinical trial of tipifarnib in patients with relapsed or refractory PTCL at ASH. As of the November 21, 2018 data cutoff date, a total of 39 patients were enrolled in the trial, including 19 patients with AITL, an aggressive form of PTCL often characterized by high levels of CXCL12 expression. Of the 13 evaluable AITL patients, two achieved a complete response and four achieved a partial response, for an objective response rate of 46%, meeting the pre-specified primary efficacy endpoint for the AITL cohort.
New AITL patent strengthens intellectual property protection for tipifarnib – In November 2018, Kura announced the issuance of U.S. Patent No. 10,137,121, which includes multiple claims directed to the use of tipifarnib as a method of treating patients with AITL. The patent has an expiration date of November 2037, excluding any possible patent term extension. The AITL patent was issued just six months after a U.S. patent was issued for the use of tipifarnib as method of treating patients with certain CXCL12-expressing cancers, namely PTCL and acute myeloid leukemia (AML). Kura continues to pursue U.S. and foreign patent protection in these and other indications.
Continued progress in dose-escalation trial of KO-947 – KO-947 is a potent and selective small molecule inhibitor of extracellular signal related kinase (ERK), which Kura is advancing as a potential treatment for patients with tumors that have dysregulated activity due to mutations or other mechanisms in the mitogen-activated protein kinase (MAPK) pathway. The Company continues to evaluate a number of doses and schedules for KO-947 and anticipates having data from its Phase 1 clinical trial in 2019.
Investigational new drug (IND) cleared for KO-539 – KO-539 is a potent and selective small molecule inhibitor of the menin-mixed lineage leukemia (menin-MLL) protein-protein interaction. Kura has generated preclinical data that support the potential anti-tumor activity of KO-539 in genetically defined subsets of acute leukemia. The U.S. Food and Drug Administration (FDA) has cleared Kura's IND application and the Company anticipates initiating a Phase 1 clinical trial of KO-539 in relapsed or refractory AML in the second quarter of 2019.
Research and development expenses for the fourth quarter of 2018 were $12.1 million, compared to $8.1 million for the fourth quarter of 2017. Research and development expenses for the full year 2018 were $46.8 million, compared to $26.4 million for the prior year.
General and administrative expenses for the fourth quarter of 2018 were $4.6 million, compared to $2.9 million for the fourth quarter of 2017. General and administrative expenses for the full year 2018 were $16.1 million, compared to $9.7 million for the prior year.
Net loss for the fourth quarter of 2018 was $16.1 million, compared to a net loss of $10.7 million for the fourth quarter of 2017. Net loss for the full year 2018 was $60.4 million, compared to a net loss of $35.4 million for the prior year. Net loss for the fourth quarter and full year of 2018 included non-cash, share-based compensation expense of $1.7 million and $8.7 million, respectively, compared to $1.4 million and $4.5 million for the same periods in 2017, respectively.
Cash, cash equivalents and short-term investments totaled $179.0 million as of December 31, 2018, compared with $93.1 million as of December 31, 2017.
Management expects that current cash, cash equivalents and short-term investments will be sufficient to fund its current operations into 2021.
Kura's management will host a webcast and conference call today at 4:30 p.m. ET / 1:30 p.m. PT today, March 5, 2019, to discuss the financial results for the fourth quarter and full year 2018 and provide a corporate update. The live call may be accessed by dialing (877) 516-3514 for domestic callers and (281) 973-6129 for international callers and entering the conference code: 8996475. A live webcast of the call will be available from the Investors and Media section of the Company's website at www.kuraoncology.com, and will be archived there for 30 days.
Kura Oncology is a clinical-stage biopharmaceutical company committed to realizing the promise of precision medicines for the treatment of cancer. The Company's pipeline consists of small molecule drug candidates that target cancer signaling pathways where there is a strong scientific and clinical rationale to improve outcomes by identifying those patients most likely to benefit from treatment. Kura's lead drug candidate is tipifarnib, a farnesyl transferase inhibitor, for which the Company has initiated a registration-directed trial of tipifarnib in recurrent or metastatic patients with HRAS mutant HNSCC. In addition, tipifarnib is being evaluated in multiple other Phase 2 clinical trials in solid tumor and hematologic indications. Kura's pipeline also includes KO-947, an ERK inhibitor, currently in a Phase 1 dose-escalation trial, and KO-539, a menin-MLL inhibitor, which is anticipated to enter into a Phase 1 clinical trial in the second quarter of 2019. For additional information about Kura, please visit the Company's website at www.kuraoncology.com.
This news release contains certain forward-looking statements that involve risks and uncertainties that could cause actual results to be materially different from historical results or from any future results expressed or implied by such forward-looking statements. Such forward-looking statements include statements regarding, among other things, the efficacy, safety and therapeutic potential of Kura's product candidates, tipifarnib, KO-947 and KO-539, progress and expected timing of Kura's drug development programs and clinical trials and submission of regulatory filings, the presentation of data from clinical trials, plans regarding regulatory filings and future clinical trials, the regulatory approval path for tipifarnib, the strength of Kura's balance sheet and the adequacy of cash on hand. Factors that may cause actual results to differ materially include the risk that compounds that appeared promising in early research or clinical trials do not demonstrate safety and/or efficacy in later preclinical studies or clinical trials, the risk that Kura may not obtain approval to market its product candidates, uncertainties associated with performing clinical trials, regulatory filings and applications, risks associated with reliance on third parties to successfully conduct clinical trials, the risks associated with reliance on outside financing to meet capital requirements, and other risks associated with the process of discovering, developing and commercializing drugs that are safe and effective for use as human therapeutics, and in the endeavor of building a business around such drugs. You are urged to consider statements that include the words "may," "will," "would," "could," "should," "believes," "estimates," "projects," "promise," "potential," "expects," "plans," "anticipates," "intends," "continues," "designed," "goal," or the negative of those words or other comparable words to be uncertain and forward-looking. For a further list and description of the risks and uncertainties the Company faces, please refer to the Company's periodic and other filings with the Securities and Exchange Commission, which are available at www.sec.gov. Such forward-looking statements are current only as of the date they are made, and Kura assumes no obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise.


Israel Kamakawiwo'ole is an iconic figure in Hawaii, a full-blooded Hawaiian singer who supported the independence movement and released a slew of wonderful albums before his untimely death at age 38. Kamakawiwo'ole started his career with the Makaha Sons of Ni'hau, a traditional band he formed with high school friends. Fifteen years and 10 albums later, Kamakawiwo'ole went solo, much to some fans' dismay. But he continued to find success with his mix of traditional Hawaiian music and American standards. His medley "Somewhere Over the Rainbow/What a Wonderful World," off 1993's Facing Future, made it into several film soundtracks. Sadly, after a lifetime spent struggling with weight issues, Kamakawiwo'ole died in 1997.


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Do judges make law uk. Do Judges Make Law? 2019-01-08
Do judges make law uk Rating: 8,1/10 1618 reviews
Do judges make the law or merely interpret the law?
There have been many circumstances. In order to eliminate all indeterminacies in the law, principles must cover all cases that might arise. Nowhere does the text of the Constitution mention the power of judicial review, and it may fairly be debated whether the framers of the Constitution intended to create such a power. Thus I shall conclude that based on the above examples, judges do make law during exceptional and rare circumstances when it is deem totally necessary for the sake of justice. The pharmaceutical company Pfizer Inc. He has to inject flesh and blood in the dry skeleton provided by the legislature and by a process of dynamic interpretation, invest, it with a meaning which will harmonise the law with the prevailing concepts and values and make it an effective instrument for delivery of justice. They argued that judges did make law.
Judicial Independence
What has been pointed out by the author raises non-trivial philosophical issues that Dworkin must face since he must take a stand on the ontological nature of moral truth; and it would seem that Dworkin's theory of what is law can only work if moral truth is objective. However, the courts do always have to follow within the limits of the constitution and they cannot exceed the constitutional limits. This statement clearly expresses that no one is above the parliament and judges should also follow it. The common law is judge made law. This in a sense created a new law. Have things changed in light of more recent developments? Precedents based on Supreme Court decis … ions alsoguide future laws giving law makers indications on what will passConstitutional muster. Therefore, there is a need for a midway to define the judge's role.
Do Judges Make Laws? Essay
Those who seek equity must do equity. Parliamentary sovereignty is the key stone in the British Constitution. The former might lead to a imperilling the legitimacy of judicial power and the latter may lead to neglect or under enforcement of the constitutional obligation of achieving and protecting the rights of the citizens, ensuring good governance and achieving the constitutional goals. However, when I have move to the real life situation in terms of case law I found that it is not always possible to declare law. Once a point of law has been decided in a particular case, that law must be applied in all future cases containing the same material facts. It then falls into the hands of the judges to interpret them and evolve the law to make a better law. Now, is there then not a difference between Hercules's view of what morality requires and of what the law requires? In the cases that follow it seems to me that there are clear indications that judges do indeed create new law where, for example, existing laws have become outdated or inappropriate.
Do Judges Make Law?
This idea is similarly seen when the judicial role is contrasted with the role of Parliament. These aids are usually labeled either intrinsic aids, which are part of the statute itself, or extrinsic aids, which are not part of the statute itself. The former might lead to a imperilling the legitimacy of judicial power and the latter may lead to neglect or under enforcement of the constitutional obligation of achieving and protecting the rights of the citizens, ensuring good governance and achieving the constitutional goals. In the late 17th century juries established the right to acquit despite the Crown wanting them to convict. In 1954, the Supreme Court held that the Takings Clause did not prohibit the government from taking blighted property that was beyond repair and using it to build schools, streets, public facilities, and provide for redevelopment. Primary law always trumps secondary law meaning if there is a primary law the court should always use the primary law for the case. It continues to be adapted to meet new situations and changing circumstances.
Do Judges Make Law In Uk Free Essays
This effectively changed the law. Traditionally and due to the doctrine of the separation of powers judicial role is really not properly legislative at all, but consist merely in stating what the existing law actually is, and interpreting authoritatively doubtful points as. The second disadvantage of the system is that even if a bad judgment is given it would live on for a very long time as a precedent. If he has to decide upon the authority of natural justice or simply the common sense of the thing he employs the kind of natural justice or common sense which he has absorbed from the study of the law and which he believes to be consistent with the general principles of English jurisprudence. There are 3 exceptions that allowed them to not obey their previous decisions. One last point about Dworkin's critique of positivism: let us suppose that his judge Hercules is faced with a hard case on contract. This controversy between the two judges is still ranging after six and a half centuries.
Adjudication can rarely be seen as a mechanical logical deduction from general premises. Austin accepted the utility of legislation by judges. There are two main sources of English Law- legislation and cases. Thus while dealing with settled rules about, for example, legislative supremacy, Hercules will need to work out a body of principles that will justify these rules. So, the question nowadays may arise as to whether the decisions judges make are construed according to an innate bias; a personal manipulation of the rules similar to that of how the Azande chicken diviners created rules. The old-fashioned beliefs and laws were dramatically changed by the judges who recognized a basic requirement to alter traditional views that had been established by prominent judges in the 18 th Century.
When Judges Make Law
This is fundamentally different from the position of Hercules who must decide for himself which body of principles provides the best justification for the established laws. Now, is there then not a difference between Hercules's view of what morality requires and of what the law requires? The answer was once obvious and uncontroversial: the latter made them and the former interpreted them. Directions by the courts The limits that are on these directions as the courts have said are that these do not amount to stepping into the shoes of the legislature and that the guidelines given by them are only to operate till the legislature steps in to make a law. Free slots, video poker, blackjack, solitaire, and more. Some situations where judges give decisions based on precedents that are completely clear but not compatible with the modern era, show that judges are in fact making or discovering laws which would subsequently become new case-laws or precedents. Principles control the interpretation of rules. The official line is of course that judges do not make law,.
Do Judges Make Law Uk Essay
Common law, Council of Europe, European Convention on Human Rights 1439 Words 5 Pages the jurisdiction holds the right to appoint another arbitrator and the basis for assuming this right is that clause would otherwise be provided out of action. A large portion of the law today is owed by principles laid down by judges themselves. In my opinion, I feel that judges in other court should not totally adhere to or follow what House of Lords did as they should try their cases on a case to case basis as some people may have been paying their tax on time but just miss out that one time and they were so heavily fined for that few dollars. One of the twin principles upon which the rule of law depends is the supremacy of Parliament in its legislative capacity. These principles provide answers to all legal cases; the reasons never run out. Thirdly, the balancing process in which principles are weighed against each other must never yield an equal weight to conflicting principles on either side of a legal question.
Do Judges Make Law or Merely Interpret Laws?
Yes, it is the role of the courts to interpret and apply the law. This is because, at the end of the day, a constitution is a piece of paper; it often takes the judiciary to enforce the respect of its demands. The claimant has to be at the scene. For the secondary law, which is the common law, the judges make this common law base on the cases and it is developed extremely slow and cautious and incremental bit by bit. So then future courts would then decide the judgment when they are considering whether or not they are bound by it. The constitution is the most supreme law of the land and its prohibition of the other arms of government to make law should be taken seriously thus if the judiciary is exercising such a powerful role, it should be more open to criticism and the contempt power should be used only rarely. Nonetheless, these activities, important and insufficiently studied though they are, must not disguise the fact that both the framework within which they take place and their chief end product is one of general rules.


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Budget Amendments - HB1500 (Conference Report)
Bill Order » Item C-39.10 #1c
NSU: Norfolk Light Rail Land Swap (language only)
Item C-39.10 #1c
Page 435, after line 1, insert:
Norfolk State University is authorized to enter into a written agreement with the City of Norfolk, the Transportation District Commission of Hampton Roads, operating as Hampton Roads Transit, and the Norfolk Redevelopment and Housing Authority relating to the Norfolk Light Rail Transit Project, pursuant to which the university will convey to the City fee simple title to a parcel of land containing 0.98 acres, more or less, and will grant a number of easements to the City to serve the operational needs of Norfolk's light rail transit system. The transit system extends along, and adjacent to, the entire southern boundary of the university's campus. As part of the consideration and in exchange, and at no additional cost to the Commonwealth, the university is authorized to acquire from the City of Norfolk fee simple title to certain properties now comprising the McDemmond Center's improved parking lot, located at the southeast corner of the intersection of Reservoir and Claiborne Avenues, as well as various remnant parcels as described in the agreement, including parcels containing 1.373, 0.198, and 0.124 acres, more or less, and a parcel comprised of a narrow strip of land lying, in part, between the rail line corridor and the university's Ballentine parking lot, all primarily to serve the parking and open space needs of the university. Prior to acceptance thereof, assurances to the satisfaction of the Governor, or his designee, shall be obtained through an environmental study indicating the properties to be acquired are free from hazardous materials and conditions."
(This amendment allows Norfolk State University to convey land for construction of the Norfolk light rail transit system, in exchange for certain parcels of land now owned by the City of Norfolk.)
Governor's Recommendations
Governor's Veto Explanation
Item C-39.10


connect is a string specifying the physical connection of the LCD display to the board; valid values are "X", "Y", "XY", "YX". Use "X" when the display is connected to a pyboard in the X-skin position, and "Y" when connected in the Y-skin position. "XY" and "YX" are used when the display is connected to the right or left side of the pyboard, respectively.
pwr is a Pin object connected to the LCD's power/enabled pin.
i2c is an I2C object connected to the LCD's I2C interface.
spi is an SPI object connected to the LCD's SPI interface.
One must specify either a valid connect or all of pwr , i2c and spi . If a valid connect is given then any of pwr , i2c or spi which are not passed as parameters (ie they are None ) will be created based on the value of connect . This allows to override the default interface to the display if needed.
Turn the display on or off, depending on the given value of on : 0 or False will turn the display off, and 1 or True will turn it on.
Set the orientation of the display. The orient parameter can be one of PORTRAIT , LANDSCAPE , PORTRAIT_UPSIDEDOWN , LANDSCAPE_UPSIDEDOWN .
Set the start-up decoration of the display. The value parameter can be a logical or of STARTUP_DECO_NONE , STARTUP_DECO_MLOGO , STARTUP_DECO_INFO .
Get a line of pixels into the given buffer.
Dump the entire screen to the given buffer.
To draw text one sets the position, color and font, and then uses write to draw the text.
scale is a scaling value for each character pixel, where the pixels are drawn as a square with side length equal to scale + 1 . The value can be between 0 and 63.
These methods are as above but don't do any clipping on the input coordinates. They are faster than the clipping versions and can be used when you know that the coordinates are within the display.
x , y , w , h specify the location of the window in the display.
The first call to this method will start the display's internal watchdog timer. Subsequent calls will feed the watchdog. The timeout is roughly 30 seconds.


text:
<?php

// set default charset
ini_set('default_charset', 'UTF-8');

// Bootstrap the framework DO NOT edit this
require COREPATH.'bootstrap.php';

\Autoloader::add_classes(array(
	// Add classes you want to override here
	// Example: 'View' => APPPATH.'classes/view.php',
));

// Register the autoloader
\Autoloader::register();

/**
 * Your environment.  Can be set to any of the following:
 *
 * Fuel::DEVELOPMENT
 * Fuel::TEST
 * Fuel::STAGING
 * Fuel::PRODUCTION
 */
\Fuel::$env = \Arr::get($_SERVER, 'FUEL_ENV', \Arr::get($_ENV, 'FUEL_ENV', \Fuel::DEVELOPMENT));

// Initialize the framework with the config file.
\Fuel::init('config.php');
#abc

redpajama_set_name: RedPajamaGithub


Introducing Trigger Points contributor Danielle Riebel, author of Pushing Through.
Everything about becoming a parent was a surprise. There's only so much preparation you can do beforehand. No one can adequately describe the immediate physical link between you and your newborn, the deep exhaustion mingled with exhilaration at meeting the child you grew within your body. The most pleasantly surprising part has been the silent radar I have for her. She could be in a room down the hallway with a fan blowing and music playing, and I'd still hear if she whimpered.
It's easy to take pride in every little thing about your child. Pooped in the potty! WIN. Ate broccoli! WIN. Mostly I love when my daughter shows love and tenderness towards her family, her friends, and people in need. After a tough day of parenting a few days ago- in which we argued over eating dinner- my daughter suggested that we should bring our food to the people around the world who don't have any. It was one of those deep breath moments, where you realize that you might have lost the battle but you're winning the war.
I find it cathartic to write about my experiences, so this project was right up my alley. It's much more difficult for me to speak face-to-face about the tough stuff.
Participating in the project affirmed my belief that I need to use my pain for good. I will never understand why I had to have such a painful childhood, and nothing will ever make it okay. But if I can help even one person by writing, talking, and sharing my story, I can accept it.
To love deeply, forgive easily, and to have fun.
I'm passionate about child birth! I am studying to become a doula, and I was fortunate enough to support one of my close friends at her birth early this year. It is profoundly humbling to witness the birth of a child, and I'd love to do it every day!
Now that [my daughter] is three and a half, it's the pillow fights, the wrestling. She'll climb on top of me, or invade my space and I feel a burst of panic, followed by a wave of anger. I've pushed her away from me and shouted countless times, to my immediate shame. It's a guttural reaction and one that I have great difficulty controlling. I say "please don't touch me" so many times a day I couldn't keep count if I tried.
Danielle Riebel is a feminist wife and mother, aspiring doula and sometimes writer. She loves Harry Potter and coffee, and believes that people who love to eat are the best kind.
I love your bravery and honesty. You give me great comfort and hope!


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Live Updates: 2020 Elections
Graham fends off Harrison in South Carolina Senate race
Democratic challenger made it the toughest race of Graham's career.
Sen. Lindsey Graham was reelected to a fourth term Tuesday night, fending off Democratic challenger Jaime Harrison in the most difficult race of the South Carolina Republican's career.
A one-time antagonist of President Donald Trump who morphed into a close ally, Graham overcame a steep financial disadvantage and the president's sagging poll numbers to defeat Harrison, the best-funded Senate candidate in history.
Graham's victory is a major relief for Senate Republicans, who were aghast at recent polls suggesting Harrison had made South Carolina a tossup after Trump won the state by nearly 15 points in 2016.
"I will do everything I can to stop the radical agenda coming from Nancy Pelosi's House," Graham said in his victory remarks Tuesday night. "So Speaker Pelosi, if you enact the agenda you're taking about, we're going to bury it in the Senate because it's bad for America."
"I've had two calls already, one from President Trump," Graham went on. "He's going to win. He is going to win. To all the pollsters out there: You have no idea what you're doing. And to all the liberals in California and New York, you wasted a lot of money."
"This is the worst return on investment in the history of American politics."
Graham won in part by portraying Harrison as a rubber stamp for the Democratic Party in Washington and by defending his close relationship with Trump, describing it as beneficial to his constituents.
Harrison rejected that argument, making the race competitive by focusing on local issues and largely eschewing Trump, who remains popular in the state.
"We proved that a new South is rising," Harrison said in his concession remarks Tuesday night. "Tonight only slowed us down."
"But a new South with leaders who reflect the community and serve the interests of everyone will be here soon enough," he went on. "Senator Graham and I may have our differences, but I hope he will maintain the spirit of cooperation he's known for while we take a step forward in creating a new South that is so possible."
In the final stretch of the campaign, Graham zeroed in on Justice Amy Coney Barrett's confirmation to the Supreme Court, touting his role leading the effort as chairman of the Senate Judiciary Committee. He also warned of dire consequences if Democrats take control of the Senate, citing Democratic leaders' vague threats of retribution if they win power.
Harrison sought to capitalize on Graham's involvement in the confirmation process, hammering Graham over his reversal from 2018, when he said he would not move a Supreme Court nomination through the chamber in an election year. Barrett was confirmed just eight days before the 2020 election.
The Supreme Court fight accelerated an unprecedented flow of cash into the state, and especially into Harrison's campaign. Harrison smashed Senate fundraising records, raising a staggering $57 million in the third quarter of 2020; Graham raised $28 million in the same time frame, less than half of Harrison's haul but enough to set a record for a Republican Senate candidate.
A super PAC aligned with Senate Majority Leader Mitch McConnell (Ky.) spent tens of millions of dollars in the final days of the campaign, an indication that Republicans feared Graham could lose.
"All I can say is this has been overwhelming," Graham said Tuesday night. "I've never been challenged like this. And I've never had more support than I do tonight. There are people all over this country [who] came to my aid. There are people who had never given 15 cents, gave me what they could."
"Ted Cruz's mother sent me 30 bucks."
Harrison sought to portray Graham as a hypocrite who long lost touch with South Carolinians as he cultivated relationships in Washington. Harrison largely avoided criticizing the president throughout the campaign, knowing it would be a risky gambit in a state where Trump remains popular.
At 65 years old, Graham has served in Congress for 25 years. His tenure began with four terms in the House of Representatives, where he gained national prominence as an impeachment manager in the trial against President Bill Clinton.
While he ran as a conventional Republican in 2020, Graham has long drawn the ire of conservatives. During his 2014 reelection campaign, Graham took the so-called tea party head-on, highlighting his bipartisan credentials and moderate views on immigration, gun control and other issues.
Harrison, 44, worked on Capitol Hill and as a lobbyist before returning home to South Carolina. He served as the chairman of the state's Democratic Party for four years and currently serves as an associate chairman of the Democratic National Committee, after losing a run for the chairman's job in 2017.
Eleanor Mueller contributed to this report.
The Biden Transition
Joe Biden may be the new president-elect — but with President Donald Trump continuing to challenge the results and Senate control up still up for grabs, the story of the election is far from over.
Biden's plans
Kathleen Hicks is Biden's pick to be the first female deputy defense secretary.
Biden has tapped three senior officials onto his Covid-19 Response team.
Biden's transition chief blasts 'obstruction' by political appointees at OMB and the Pentagon.
Trump's unplanned gift to Biden is that clean energy is on the rise.
Trump and the GOP
Sen. Josh Hawley pledged to challenge Biden's victory in Pennsylvania on Jan. 6.
Nancy Pelosi will seat a Republican in a contested Iowa race.
Congress and the coronavirus could quash Trump's Electoral College gambit.
Sen. Ben Sasse delivered a critique of his Republican colleagues challenging 2020 results.
Coming up: Georgia Senate runoffs
A judge is seeking a deal to limit voter challenges in the Georgia runoff.
Joe Biden and Kamala Harris are going back to Georgia before the Senate runoffs.
Strong early voting turnout gives Democrats hope in Georgia runoffs.
Sens. Kelly Loeffler and David Perdue side with Trump on $2,000 stimulus payments.
Senate,
Lindsey Graham,
Jaime Harrison,
2020 Elections,
2020 Presidential Candidates,
2020 Election day live updates


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Q: How to change Android icon everywhere? I am trying to change the app icon in my app in Android Studio. I replaced all ic_launcher and ic_launcher_round images in all their respective folders. The icon changed in the app menu, however, when I press the square button in my phone (the one to clean cache and remove all applications) it still appears the default icon.
Link to an example picture
I don't know where else that icon may be inside my project. Any suggestions?

A: i did the same and it's work on React native project, try to clean , rebuild and check your AndroidManifest.xml
 android:icon="@mipmap/ic_launcher"
android:label="@string/app_name"
android:roundIcon="@mipmap/ic_launcher_round"

A: I suggest to change launcher icon using asset studio in Android Studio. You have information how to do it here in official documentation. Also it's good to use vector image and add it through Asset studio.
Also, be aware that after adding new icon, launcher on Your phone could have it cashed, so restart Launcher app or You phone (depends on what launcher You use, for example Nova Launcher have restart option in settings).
When designing icon stick to official guidelines to make Your icon adaptive.

redpajama_set_name: RedPajamaStackExchange


Vaccinations are an important part of disease prevention in an animal health program. Vaccinations need to be combined with specific management practices for best control of some diseases. Before embarking on a vaccination program for your herd, contact your veterinarian, stock inspector or beef adviser for up-to-date advice. The following table provides details about key vaccines used in Queensland herds. When administering vaccines, always follow the manufacturers' instructions. For more information on handling, administering and storing vaccines see Principles of using vaccines.
5-in-1 covers five clostridial diseases, namely pulpy kidney (enterotoxaemia), black disease, tetanus, blackleg, and malignant oedema.
7-in-1 covers the same diseases as 5-in-1 plus Leptospira harjo and Leptospira pomona.
Two injections of 5-in-1 4–6 weeks apart. At your discretion, but recommended in areas where there is high risk of any of these diseases. Calves from 6–8 weeks to 2 years old. Branding and weaning – assuming that these are not more than 6 weeks apart for maximum protection. Giving only one vaccination at branding provides only limited protection for 4–6 weeks.
There is a small window where tetanus could be a problem. The normal incubation period for tetanus varies between three days and four weeks. Ideally calves should be vaccinated before branding. Development of immunity to most bacterial vaccines is 10–14 days, so there is a small risk that some vaccinated calves at branding could still get tetanus. Unvaccinated weaners should be vaccinated immediately.
Two injections 4–6 weeks apart. Yes. For best effect the annual booster should be given at mid-pregnancy to ensure a high level of protection when reproductive problems are most likely to occur. Maiden heifers and pregnant cows. Vaccinate maiden heifers (2 injections) before mating. Then all pregnant animals at mid to late pregnancy. If heifers have had two 7-in-1 injections, an annual vaccination mid to late pregnancy is required.
Bulls should also be vaccinated if there is a disease problem. Leptospirosis is diagnosed by serology. Blood samples are required from 20–30 cows, and are best collected during the wet season when the disease is most prevalent. In an outbreak of leptospirosis, all calves on the property should be vaccinated.
Two injections 4–6 weeks apart. Yes. Current season's sale cattle and bulls. Spring. Too expensive to treat the whole herd. Consider treating valuable animals.
This is a difficult vaccine to handle because: of the small pack size; it must be used within 8 hours of reconstituting, and; it cannot be connected to a vaccinator gun.
One injection OR two injections 4–6 weeks apart – depending on the vaccine used. Yes. All susceptible animals. When convenient, but preferably not at the same time as another vaccine. Vaccines are available that give up to three years' protection with a single injection. However their effectiveness depends on whether animals get exposed to botulism during that time. If it is a low risk area, annual vaccination is recommended.
Deaths from botulism are usually associated with phosphorus deficiency. If cattle are seen chewing bones it could mean you need to feed phosphorus (or protein)— just because you feed phosphorus doesn't mean cattle are safe from botulism. The only really safe way out is to vaccinate. Botulism vaccination is recommended for all herds in northern Australia.
One injection. No. All animals including home-grown and introduced, particularly animals considered 'at risk', e.g. cattle with lower Brahman content. Any time but ideally at weaning (3–9 months of age). Consider a second vaccination for expensive/stud animals introduced from tick free areas.
Contact the Tick Fever Centre, phone 07 3898 9655, for information on tick fever vaccination programs including choice of vaccine, vaccinating introduced susceptible adult cattle, and revaccination.
Two injections 4–6 weeks apart. Yes. All bulls and in infected herds, vaccinate two year old heifers with one dose about one month before mating. One month before mating. Recommended for bulls in all breeding herds.
Vibriosis is a very common infertility disease which mainly affects maiden heifers. Vaccinated bulls will not spread the disease.
Two injections 4–6 weeks apart. Yes, 2–4 weeks before mating. All breeding cattle including bulls. Introduced females and introduced bulls. Second initial vaccination should be 2–4 weeks before mating. Seek professional advice before vaccinating. Vaccination may be unwarranted (see below).
In a breeding herd, it is valuable to know whether the pestivirus is endemic or not. Testing for antibodies in blood from a group of up to 30 older cows born on the property will indicate this. The group which usually suffers the biggest loss is maiden heifers. Therefore, well before selection and maiden mating, testing antibodies in blood from up to 30 of these can indicate whether one or more persistently infected animals (PIs) is infecting the group or not. If PIs are not present in a heifer group within an endemic herd, then vaccination is indicated. Vaccination against pestivirus infection of naïve heifer groups before first mating is expected to be profitable when only 1% chronic loss is incurred.
In naïve herds, the level of vigilance has to be much higher to prevent financial loss. For more information about pestivirus visit the Queensland Government BVDV web page.
For more information about these diseases see Health and disease.
Ted Vinson and Felicity Hamlyn-Hill, formerly Queensland Government.


An incredibly rare opportunity to purchase a four bedroom family home on one of East Finchley's most sought after streets.
A four bedroom family home on one of East Finchley's most sought after streets. The property, which is spread out generously over three floors, comprises four reception rooms, kitchen/ dining room, study, wine cellar, utility room, four double bedrooms (master with en suite), two further bathrooms and a WC. Further benefits include high ceilings, Victorian bay windows and original fireplaces. Southern Road is located just moments from Cherry Tree Wood and close to the amenities of the High Road and Muswell Hill Broadway as well as East Finchley tube.
The property is well located for school catchments.
This property has had a full basement conversion.


This wasn't your normal "farm" wedding. David and Melissa are both so unique in so many ways and that's one of the reasons that this wedding was such a blast! Ever since their engagement session, I knew that their wedding day would be awesome. They love music, they love their friends, and they love doing things differently. Their wedding had more of a "bohemian" feel than a "country" feel and I loved that!! As their friends started to show up at the ceremony location, I was with them on top of the hill at the guy's cabin and we could see the cars pulling in.
I have photographed at Maymont Park so many times and to be honest, sometimes it's hard to find inspiration at the same spot over and over again. However, after Bryan and Elyse's engagement session, I realized that you can easily find new inspiration simply through AMAZING outfit choices!! I could have photographed Elyse walking in that gorgeous tulle skirt ALL EVENING!! She was stunning and their outfits were so perfect for Maymont's architecture!! We started in the upper garden and that's when I learned several things about them….
So we've been living in an apartment for a month now! The only thing I have to compare apartment living to is my freshman year of college and so we're quite new to this! After only a month of living here, I feel like we're getting the hang of it! However, there have been a few things that we are unsure about and I'm really hoping we're not weird. So if you are currently living in an apartment or have lived in an apartment in the past and these things have happened to you or crossed your mind… PLEASE let us know that we're not the only ones!!!


The super-technical Schoeller c_change jacket that adapts to your body's heating and cooling systems in a windproof, waterproof design.
The jean made from the most technical Schoeller c-change fabric to be durable, windproof and waterproof as it adapts to your body's heating and cooling systems.
Our warmest ski outerwear jacket in stretch woven, insulated hardshell fabric that features Recco Avalanche Rescue Technology.
This hardshell jacket brightens the slopes with a fun print in a fully waterproof design and fine twill outer fabric.
The innovative InsulEight down jacket with stretch woven fabric for full lightweight mobility, plus zip-off sleeves to convert into a vest.
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Packable InsulEight 800-fill down warmth with urban styling and a removable hood with cinch cords.
The ultra-comfortable tall boot with a side zip for easy on/off.
The stretchy softshell pant that offers elemental protection and full mobility down every run.
No matter the weather and no matter the terrain, softshell is the way to go if you want full mobility down every run.
Customize your look with this strappy boot from Off the Beaten Track that features a wire bead cuff so it stays in place wherever you fold it.
The equestrian-inspired boot with a taller heel to elevate any expedition.
The yummy full cashmere tunic sweater with a slouchy rib cowl neck that makes the perfect outfit when you just add leggings.
Our fully seam-sealed waterproof hardshell pant in stretch woven fabric for full mobility and flattering design lines.
In the perfect style to complement your look, this rain trench is totally waterproof, seam-sealed and fully lined.
Get the skinny on the slopes with this softshell pant that has old-school stirrups to hold it in place.
The strappy ballet flat that offers unbelievable comfort with a memory foam footbed and deerskin lining.
Memory foam gives this Gentle Souls shoe total comfort in a ballet flat with a twist.
Make the crossover from your steamy yoga studio into the cool outdoor air with this soft, wicking cashmere sweater.
Your favorite pullover sweatshirt gone uber-luxe in 100% cashmere with a cozy cowl-neck hood.
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Get into the fold with this customizable foldover cuff, studded boot from Off the Beaten Track .
Soft, lightweight Downalicious with InsulEight fill in the most feminine down jacket for life in the cold.
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The desert boot gets urban styling with rear buckle details in this comfortable flat boot from Born .
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Softshell made for the urban wanderer in a wind- and water-resistant, flattering trench.
The wind- and water-resistant jacket that's ideal for travel plans that include drizzly forecasts.
There's no cooler down jacket than this semi-fitted, shirt-inspired design.
Layer up for mountain town adventures after you get off the slopes in this goose down vest with a removable hood and faux fur.
The ultimate companion for snowshoeing or Nordic skiing with smooth-faced fabric and a cozy, fleecy interior.
The legendary ASICS cushioning run shoe that offers a supremely comfortable ride rolls out this year a half ounce lighter.


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Elandsfontein may refer to:

 Elandsfontein, an archaeological site near Hopefield, South Africa
 Elandsfontein, a farm homestead that is now a suburb of Alberton, South Africa

redpajama_set_name: RedPajamaWikipedia


The versatile actor Pankaj Tripathi has explored variety of platforms and mediums to entertain his audiences more than a decade. He is one of the best actors currently Bollywood has. Pankaj after giving memorable performances in his last few releases like Newton, Bareilly Ki Barfi, Stree, web show Mirzapur Pankaj now sets his eyes on Hollywood.
Pankaj we now hear will soon start shooting for his first ever Hollywood film with none other than Hollywoods hot favourite actor Chris Hemsworth aka Thor from Avengers of the Marvel Universe. In November last year, Chris was inIndia to shoot debutante director Sam Hargrave's thriller film Dhaka. Sam has been the second unit director for Avengers Infinity War, Atomic Blonde. They shot principal portions of the film in Mumbai and Ahmedabad.
The film also stars Golshifteh Farahani, David Harbour, Randeep Hooda, Manoj Bajpayee amongst many others. As per the sources Pankaj Tripathi will be joining the cast in Bangkok, Thailand to shoot next leg of the film. This would be the first time Pankaj will be seen in a Hollywood project working with an international crew. Pankaj will be seen in a pivotal character sharing screenspace with Chris. The film Dhaka, is thriller and will be released on Netflix Originals.


I expected more Dylan from Pitchfork's list. Or maybe that's just because I've been listening to so much Dylan lately.
To me, "The Times They Are A-Changin"' is pure wonder. I can barely believe that one, quite young, man wrote this Sermon on the Mount Part II. It's like the song has always existed. That first verse, "Come gather round people/where ever you roam…" gives me chills every time I hear it.
You are lucky if you grab the creative and do it, and let people know about it. By studying old folk songs, and living that lifestyle, Dylan was able to perfectly emmulate, and actually improve upon, folk music in a way no one could have imagined. He has an old soul.
Anyway, I am disappointed that no early Dylan songs were included in Pitchfork's list. And out of nowhere the Jackson 5 get #2. It should have been "Be My Baby," a song that inspired so many, including Brian Wilson.
Bob Dylan is beyond description. I have loved Dylan since I heard "Like A Rolling Stone" when it was released..yes I am old enough to remember it on AM Radio. Everyone else was imitating the British Invasion, or the Motown Sound, and then over there just blowing people away on his own was Dylan.


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Q: Securing service principal in azure We are using a service principal to create the infra in azure . we want to secure the client secret and for that we are planning to use azure key vault. if we store the client secret in key vault. we would require another service prinicpal to read the secret from the key vault and how do we secure that secret. We want to know how to resolve this and how is it done in enterprise scenario
Thanks


Cognitive-behavioral therapy (CBT) is a widely-used form of talk therapy that helps people overcome a variety of mental health and substance use disorders. In CBT, individuals work with counselors to identify patterns of thought and belief that lead to unwanted behaviors, such as the misuse of drugs or alcohol. Through counseling sessions, activities and exercises patients learn to respond to their thoughts and emotions in more constructive ways, rather than with addictive behaviors.
Who Should Get Cognitive Behavioral Therapy?
Where Can I Receive Cognitive Behavioral Therapy?
CBT was first used in addiction treatment as a method to prevent relapse for problem drinkers. It was later adapted for users of cocaine and is now used in the treatment of other addictions, as well as to address a range of mental health issues such as psychological disorders, co-occurring disorders, trauma, and family conflicts.
CBT is done in a structured way, sometimes within a limited number of treatment sessions that can help people quickly identify and address problem areas in their lives. It is often combined with other treatments, such as medications and/or traditional psychotherapy, and can be easily integrated into a larger treatment plan.
CBT is a blend of two forms of therapy: cognitive therapy and behavioral therapy.
Works to change unhealthy behavior patterns.
CBT helps individuals learn to solve their problems by examining their thoughts and actions and working to modify them in ways that can be applied to daily life. If used regularly, these techniques can become habits that make a life free from drugs and alcohol feel less challenging and more natural.
Cognitive-behavioral therapy provides people in recovery with the means to manage and alter their emotional state. This powerful tool allows people to take responsibility for their own emotions, and even exercise some degree of control over what they feel and how intensely they feel it.
In substance abuse and addiction treatment, CBT is often combined with medications, or with other forms of therapy, but it can be effective as a standalone treatment as well.
Cognitive behavioral therapy is often conducted on a one-on-one basis with a counselor, but it can also be conducted in a group setting. In CBT, patients break down their problems into smaller parts so that they can identify the thoughts, feelings, and beliefs that lead to unwanted behaviors.
The logic behind CBT a bit like this: your thoughts and beliefs about a situation or event in your life can affect how you feel about it emotionally, which in turn affects how you behave in response. Recognizing those thoughts and beliefs can allow you to modify them in ways that support healthier, more productive and positive behavior.
There are different techniques and approaches that a therapist may use in cognitive-behavioral therapy. While being treated with CBT your therapist may coach you through several of these methods in an effort to meet treatment goals and alleviate the symptoms you are experiencing.
Behavioral experiments are used to test the validity of false or irrational beliefs and thought patterns, so they can be modified to change how the patient reacts to life in the future.
For example, a patient who believes that they must always do everything perfectly may be instructed to show up late to a session or to turn an assignment in late. By actively testing the faulty belief, the patient can acquire actual proof to support a more positive state of mind.
Thought records also help patients determine the validity of their thoughts and beliefs. By working with a therapist or alone, patients may identify a particular belief, such as "my therapist thinks I'm useless" and come up with evidence for and against the idea. This evidence can be spoken out loud, thought through silently, or written down on paper. The point is to come up with concrete evidence to evaluate, weigh, and provide the individual with support for more balanced, realistic, and healthier thoughts and beliefs.
Pleasant activity scheduling involves scheduling healthy daily activities that you enjoy, and that you may not normally do. It can be simple or more complex – from reading a chapter in a novel to making a nice dinner.
Another method of this strategy is to schedule an activity a day that gives you a sense of mastery, competence, or accomplishment. By scheduling these positive actions as if they are official appointments for a haircut or dental checkup, the individual is much more likely to follow through. Scheduling also emphasizes the importance of nurturing the self and the recovery process, so good self-care doesn't get neglected.
In this method, a patient will put things they normally avoid on a list, such as things that distress them or would normally lead to substance use. They rate those situations or things on a scale by how distressed they make you or how likely they are to lead to substance use. Then, with the support of a therapist or a trusted friend or family member, the patient can work through the list from lowest to highest, exposing themselves (safely) to these situations so that they can become more comfortable and confident in response. Patients are guided through this process with their cognitive behavioral therapist and are discouraged from doing anything that could endanger their recovery. Exposure to high-risk situations should be avoided.
This is similar to situation exposure hierarchies but involves picturing the situations instead of experiencing them. With imagery-based exposure, the patient can safely confront higher risk situations and build up confidence and coping skills within the safety of a counseling session.
Patients bring experiences to mind that usually provoke strong negative emotions or behaviors, trying to remember with lots of sensory detail to make the exercise as vivid as possible. They then try to label the thoughts, emotions, and behavioral urges experienced. This type of exposure may be repeated until the level of distress decreases, and/or a more constructive response to the situation begins to feel natural.
Cognitive-behavioral therapy works faster than other talk therapies. CBT deals with your current problems, rather than focusing on issues from your past. It looks for practical ways to improve your state of mind on a daily, moment to moment basis.
With CBT, patients often have homework assignments and other types of active practice outside of counseling sessions.
Cognitive behavioral therapy can help any addiction and any co-occurring disorder, as long as the patient is able to understand and implement the methods. This means that patients in the midst of a crisis, or in the early days of detoxing from substances may not be ready for CBT, but as soon as the crisis is stabilized and/or withdrawal symptoms are controlled, CBT can begin.
Most addiction treatment programs will include cognitive behavioral therapy in their treatment plans. Before attending a treatment facility, you can call and speak to a specialist about your options.
After patients finish a course of cognitive behavioral therapy, the skills, tools, and techniques acquired during the sessions can then be applied every day throughout recovery. Eventually, CBT strategies will become second nature, and living without drugs and alcohol will feel more natural than active addiction does.


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Clinical Trial Outsourcing is a Balancing Act for Pharmaceutical Companies
Tags: clinical trial outsourcing Clinical Trials global clinical outsourcing clinical outsourcing
The number of clinical trials being outsourced is increasing and the industry is working together to develop ground-breaking partnerships that focus on creative contracting and effective oversight.
According to a recent Pharma IQ survey, 43 per cent of Pharma professionals do not think the oversight of their clinical trial vendors is effective and 100 per cent claimed that the increasing levels of regulatory scrutiny are adding unnecessary pressure. This is particularly worrying given recent findings about the pervasiveness of clinical trial outsourcing.
Why is outsourcing on the increase?
The report by Kalorama Information found that more than a third of clinical trials conducted by pharmaceutical firms are now outsourced to vendors. Titled Outsourcing in Drug Development: The Contract Research (Clinical Trial) Market, it explains that clinical trial outsourcing has moved from being a "should" to a "must" for drug developers and manufactures, Pharma Times reported. This is no doubt because outsourcing is a much more cost effective process than undertaking work first hand.
It commented: "The cost and time of developing and bringing a drug to market is over $1.3 billion (£830 million) and often takes as long as 15 years, if not longer. Because of this, major pharmaceutical marketers continue to outsource stages of development, and over the years Kalorama Information has observed this process."
Expenditure on clinical trial outsourcing has also increased in the last two years, the source reported, with the amount of global research and development expenditure allotted to outsourced drug developers reaching $36.6 billion this year. This is an increase of over six per cent on the $31.8 billion spent in 2009. Figures of in-house drug development expenditure seemed to back up this shift towards outsourcing. Since 2010, the proportion of clinical trial costs spent internally decreased from 74 per cent to 62 per cent, a dramatic fall.
"The demand for new drugs remains unabated, but the cost and need to bring those drugs to market is ever-increasing and intensifying," the report noted, explaining that a key cost of drug development is late-stage attrition during clinical trials. These cost pressures, particularly in the current climate, have led to more and more firms adopting outsourcing, which allows for a faster development process, as a way to increase profits.
The risk to innovation
However, some experts believe that while this move to outsourcing is not surprising, it will stifle innovation. Mark Lowman, Andreas Hoecht and Paul Trott, from the University of Portsmouth Business School, warned that to shift could have long-term implications on originality, as it reduces the ability for pharmaceutical firms to benefit from the knowledge and learning opportunities that arise from undertaking the process themselves.
"The move away from the integrated in-house model may have been a rational reposnse to the pressures of the industry but is problematic from the innovation perspective," the researchers explained. They claimed that activities that can seem irrelevant and mundane at the time can actually be crucial later down the line, due to the opportunities they create. To illustrate this point, the team cited the example of Viagra, which was only identified because of the statistical data from the outcome of clinical trials by Pfizer.
Clearly there are pros and cons to both in-house development and the move towards outsourcing. However, pharmaceutical firms are commercially led and will seek to cut costs and increase margins, striking the balance between this and encouraging innovation is vital.
The Global Clinical Outsourcing Forum will be hosted from 24th – 25th April, 2012 in Amsterdam, The Netherlands. For more details, visit the website: www.globalclinicaloutsourcing.com,
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Joe Biden's Vatican Ambassador Nominee Voted to Force Americans to Fund Abortions
National | Micaiah Bilger | Oct 18, 2021 | 10:18AM | Washington, DC
Joe Biden's choice to represent the U.S. to the Vatican voted to force Americans to fund the billion-dollar abortion industry and its work killing unborn babies in abortions.
Like Biden, Joe Donnelly, a former U.S. senator from Indiana, professes to be a devout Catholic and personally pro-life. But his voting record tells a different story.
Biden recently nominated Donnelly as the U.S. ambassador to the Vatican, and the U.S. Senate likely will confirm him without controversy.
"… Donnelly is about as faithful as Biden himself. That is to say, not at all," The Federalist intern Haley Strack responded.
She pointed to the Democrat politician's voting record in the U.S. Senate from 2013 to 2019 and the U.S. House from 2007 to 2013 to make her point.
Here's more from the report:
In March 2010, Donnelly voted for taxpayer-funded abortion through Obamacare. In August 2015, the senator cast a pro-life vote by voting for Cloture On S. 1881, A Bill To Prohibit Federal Funding For Planned Parenthood. Just months later, "the last pro-life Democrat" decided millions of innocent lives weren't worth political pressure, so he voted to allow the abortion provider to receive taxpayer funding.
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"Planned Parenthood has not been found to be in violation of any federal laws," the senator said at the time. "I am committed to ensuring women have access to quality health care, like cancer screenings and wellness visits, and that our health care providers are in compliance with federal law."
In 2017, Donnelly voted against President Trump's plan to deny states the ability to use federal Title X funds for abortion providers. In 2018, he voted against another amendment that would have stopped taxpayer funding from going to abortion corporations like Planned Parenthood, earning him the title "Deceptive Donnelly" from Marjorie Dannenfelser, president of Susan B. Anthony List.
Donnelly's voting record on the abortion issue was mixed, but he sided with the abortion industry more often than the pro-life movement. In 2018, his pro-life voting record was just 28 percent, according to National Right to Life.
In 2019, Donnelly lost his seat to pro-life Republican U.S. Sen. Mike Braun. After the loss, Donnelly helped to lead the Catholics for Biden campaign to elect the pro-abortion Democrat to office, according to Breitbart. During Biden's election campaign, Donnelly praised him as a man whose Catholic faith "beats deep in his heart every moment of his life."
Biden professes to be Catholic, but he has embraced an increasingly radical pro-abortion agenda. Earlier this month, he implemented a new rule restoring about $60 million in taxpayer funding to the largest abortion chain in the U.S., Planned Parenthood.
He also has been filling his administration with radical abortion activists, including lawyers who want to send pro-lifers to jail for exposing Planned Parenthood's aborted baby body parts trade. Less than a year ago, Planned Parenthood CEO Alexis McGill Johnson bragged openly about her strong influence in staffing the Biden administration.