text:
E3ligase signal
For example, the structure of another HIV protease inhibitor tipranavir is shown on the left.
Pellets containing cell membrane materials were collected by cent
Pellets containing cell membrane materials were collected by centrifugation at 200 000 g for 45 min at 4 °C and solubilized in 10 mM HEPES buffer (pH 7.4). Finally, OMPs were separated on SDS-PAGE and visualized by Coomassie blue staining. Normal rabbit serum was obtained from the Laboratory Animal PARP inhibitor Center of South China in Guangzhou, China. Porcine serum consisted of a pool of sera collected from five healthy piglets (3–4 weeks old) from a farm free of Glässer's disease.
Both sera were filter-sterilized (0.22 μM) and aliquots were stored at −80 °C. Some aliquots of the sera were treated at 56 °C for 30 min to inactivate the complement. The serum bactericidal assay was performed with porcine and rabbit sera as previously described (Cerda-Cuellar & Aragon, 2008) with some modifications. Briefly, 100 μL of each aliquot of fresh serum or heat-treated www.selleckchem.com/products/3-methyladenine.html serum was mixed with 100 μL of bacterial suspension (approximately 1 × 108 CFU mL−1) to achieve a final concentration of 50% serum. Then, 180 μL of each aliquot of fresh serum or heat-treated serum was mixed with 20 μL of bacterial suspension (approximately 1 × 107 CFU mL−1) to achieve a final concentration of 90% serum. The mixtures were incubated at 37 °C for 1 h with gentle shaking. After incubation, 10-fold serial dilutions of the samples were made and placed on TSA plates containing inactive bovine serum and NAD. The plates were incubated at 37 °C with 5% CO2 for
36 h, Dapagliflozin at which point the colonies were counted. The percent survival was calculated by the ratio of colonies in fresh serum to those in heat-treated serum. Each H. parasuis strain was tested in three independent experiments. Comparison of several test series was evaluated by analysis of variance (anova). The significance of differences was determined using Student's t-test. A P value of < 0.05 was considered statistically significant. Using the method of Bigas et al. (2005), no transformants were obtained when the seven different clinical isolates and four reference strains
listed in Table 1 were transformed with the pZB2 plasmid carrying the ompP2::GmR cassettes. This result suggested that the strains might not share the reported USS (5′-ACCGAACTC) or might be non-transformable strains. Therefore, we searched the H. parasuis SH0165 strain genome (GenBank accession no. NC_011852) to determine the prevalence of the alternative motif, 5′-ACCGCTTGT. In total, 523 occurrences of this motif were found, a much higher number than of the reported USS (13 occurrences, including its complement). Recently, Xu et al. (2011) also reported the 5′-ACCGCTTGT motif as a DNA USS in the SH0165 strain genome. To confirm that the 5′-ACCGCTTGT motif was required for H. parasuis transformation, the hepII gene, containing this motif 842 bp from its translational start point was selected for test transformations. Of the seven isolates and four reference strains, only the SC096 strain was transformable with plasmid pZB3 under the conditions tested.
The diagnosis and treatment of genital infections in any individu
The diagnosis and treatment of genital infections in any individual have clear benefits in terms of both individual morbidity and possible infectivity to any sexual partner. In pregnancy, the welfare of the baby is an additional issue. However, apart from the recommendation that all pregnant women should be screened for HIV, HBV and syphilis, asymptomatic HIV-uninfected pregnant women in the UK are not routinely screened for genital infections. In HIV-positive pregnant women, additional considerations are the potential effects of the presence of a genital infection on MTCT of HIV-1. This could occur through
an increase in the HIV-1 VL in the genital tract and/or BMS-354825 chemical structure the presence of chorioamnionitis. In addition, certain infections may be linked to premature birth, an event that occurs more frequently in HIV-positive women when compared with HIV-uninfected women. VL in cervicovaginal specimens has been shown to correlate with HIV-1 MTCT [6]. Genital tract VL will usually mirror the plasma VL [7], but there is increasing evidence of compartmentalization of HIV-1 between the plasma and genital tract. Genital tract HIV-1 has been detected in women with an undetectable plasma VL [[8],[9]] and genetic diversity of virus from the two compartments has been reported [10]. A number of factors
may be responsible for this, including differential drug penetration into body compartments and the presence of Metabolism inhibitor genital tract infections. With increasing numbers of women in the UK aiming for and achieving a vaginal delivery an increasing number of fetuses are exposed to the cervicovaginal
secretions of HIV-positive women. The clinical significance of this is not clear. Data from the UK and Ireland [2] and France [11] showing no difference in MTCT associated with mode of delivery in women with an undetectable VL provide some reassurance that potential discordance may not be clinically relevant but further research is http://www.selleck.co.jp/products/cetuximab.html warranted. It has long been recognized that genital infections, in particular ulcerative diseases, are associated with an increased risk of sexual transmission of HIV [[12],[13]]. This may be a consequence of an increase in local HIV replication resulting in a higher VL in genital secretions, secondary to the presence of specific microorganisms, and/or ulceration and inflammation [[14],[15]]. Organisms associated with bacterial vaginosis (BV) have been shown to stimulate HIV expression in vitro [[16],[17]]. A study from Kenya demonstrated a reduction in cervical mucosal shedding of HIV-1 RNA following treatment of both gonococcal and chlamydial cervicitis [18]. A study from Zimbabwe has shown a correlation between herpes simplex virus type 2 (HSV-2) antibody status and HIV-1 MTCT [19]. A study from Thailand of perinatal cervicovaginal lavages showed that HSV-2 shedding was associated with increased risk of intrapartum HIV transmission and that the effect was independent of perinatal cervicovaginal lavage and plasma HIV VL.
A second result was obtained
A second result was obtained buy Regorafenib by using SR95531 at concentrations sufficiently high to rapidly block the tonic current above the chloride equilibrium potential (ECl). Surprisingly, below ECl, SR95531 (10–40 μm) activated a sustained inward current, associated with a conductance increase, and resistant to bicuculline or PTX (100 μm). Similarly, after blockade of the bicuculline-sensitive current, SR95531 activated an
outward current above ECl. The bicuculline-resistant anionic current activated by SR95531 could be blocked by a GABAC receptor antagonist. Thus, two types of inhibitory GABA receptors, belonging to the GABAA and GABAC families, are able to show a sustained activity in HMs and provide promising targets for neuroprotection
under overexcitatory situations known to easily damage these particularly fragile neurons. "
"Food restriction has been reported to have positive effects on cognition. This study examines how another environmental Apitolisib mouse factor, daylength, can alter the impact of food restriction on the brain and behavior. Female California mice (Peromyscus californicus), housed on either long days (16 h of light and 8 h of darkness) or short days (8 h of light and 16 h of darkness), were restricted to 80% of their normal baseline food intake or provided with food ad libitum. Testing in a Barnes maze revealed that the effects of food restriction depended on photoperiod, and that these effects differed for acquisition vs. reversal learning. During acquisition testing, food restriction increased latency to finding the target hole in short-day mice but not in long-day mice. In reversal
testing, food restriction decreased latency to finding the target hole in long-day isothipendyl mice but not in short-day mice. Latency to finding the hole was positively and independently correlated with both errors and time spent freezing, suggesting that changes in both spatial learning and anxiety-like behavior contributed to performance. Short days increased hippocampal expression of the synaptic protein, synapsin I, which was reversed by food restriction. Short days also reduced plasma corticosterone levels, but diet had no effect. There was no effect of diet or photoperiod on hippocampal expression of the glial marker, glial fibrillary acidic protein. The present findings suggest that, in female California mice, the differential effects of food restriction on acquisition and reversal learning are photoperiod-dependent. These results justify further testing of the relationship between food restriction and hippocampal synapsin I in the context of spatial learning. "
"The lateral habenula (LHb) is an epithalamic region with a crucial role in the regulation of midbrain monoaminergic systems. Over the past few years a renewed interest in the LHb has emerged due to studies highlighting its central role in encoding rewarding and aversive aspects of stimuli.
Countries rarely traveled in by the Bank staff, with person-days
Countries rarely traveled in by the Bank staff, with person-days lower than 147 (15 percentile) within 3 years, were
not included in the incidence calculation and were marked as "not enough travel data" to map. A follow-up survey was distributed to the 341 staff reporting at least one road crash over the past 3 years, asking for more detailed descriptions of crash circumstances. The questions addressed who was driving, use of seatbelts, speed of the car, other circumstances of the crash, response time of assistance, need for medical treatment, use of first aid kit, use of cardiopulmonary resuscitation (CPR), need for sick-leave, and nature of the injuries. A total of 3,760 people took the online survey (response rate = 25.6%). More than half of the respondents have at least four travel missions in a year and around 18% of the respondents Mitomycin C clinical trial traveled at least or more than 10 times during a year. Table 1 shows the demographic and travel-related profiles of respondents. Of 3,109 survey respondents who reported that they made at least one mission in a typical year, we were able to match 3,004 with HR staff travel data. All analyses were conducted among the 3,004 matched travelers. A total of 4,100 near crashes were reported by WBG staff, which can be converted to 1 near crash per 15 missions.
There were 341 road crashes reported, or 1 in 175 missions. The most often stated contributing factors included driver's decision errors, speeding, and road or weather conditions. these Forty percent of crash victims reported that seatbelt was not in use at the time of crash. Seventy percent find more of crashes took place in taxis. The distribution of high-risk countries, regardless of the indicator used to measure risk profile, reflected the pattern of typical travel destinations in the Bank, including mostly low- and middle-income countries. Responses to the question about perception of road safety were mapped to show overall picture of safety concerns of countries around
the world (indicator 3). The top 10 high-risk countries with respect to perception of risk were India, Kenya, South Africa, Egypt, Nigeria, Vietnam, Indonesia, Pakistan, Bangladesh, and Tanzania. The reported crashes and near crashes were highly associated. The correlation coefficient was 0.89, which is a strong positive association. Therefore we selected indicator 8 (incidence rate of total number of crashes and near crashes), as a main indicator of road safety risk by country. The list of high-risk countries for this indicator is presented in Table 2, the map in Figure 1. In response to the question "Do you have any suggestions to provide better road safety for Bank travelers?," 1,068 suggestions and safety comments were collected and categorized in Table 3. Similar responses were compiled under the most common statement to avoid redundancies, and finally condensed to themes.
Currently available data derive from cohort studies which have be
Currently available data derive from cohort studies which have been analysed in different ways, and which cannot fully adjust for confounders, the effect of which may be large. Specifically, the balance between
any small benefits of ART in this group and the risk of any side effects is unclear. The current revision of the guidelines will not alter this recommendation. The START trial (which is continuing to recruit in many countries around the world) is designed to specifically address exactly this issue for people with CD4 counts > 500 cells/μL such that future guidelines will have a sufficient evidence base to make an informed decision when considering earlier initiation of therapy for an individual BMS 354825 patient. The BHIVA treatment guidelines were developed
primarily with patients from the CHIR-99021 supplier UK in mind. In other settings, where there are particularly high TB rates, constraints on delivery of care, and high losses through the care and treatment cascade, earlier ART initiation may be more important to increase retention of patients in care after diagnosis. We recommend patients presenting with an AIDS-defining infection, or with a serious bacterial infection and a CD4 cell count <200 cells/μL, start ART within 2 weeks of initiation of specific antimicrobial chemotherapy (1B). Proportion of patients presenting with an AIDS-defining infection or with a serious bacterial infection and a CD4 cell count <200 cells/μL started on ART within 2 weeks of initiation of specific antimicrobial chemotherapy. This recommendation is largely based on the ACTG 5164 study that demonstrated
fewer AIDS progressions/deaths and improved cost-effectiveness when ART was commenced within 14 days (median 12 days; IQR 9–13 days) compared NADPH-cytochrome-c2 reductase with after completion of treatment for the acute infection (median 45 days; IQR 41–55 days) [17, 18]. Those with TB as the primary infection were excluded from this study, and the majority of patients enrolled had Pneumocystis pneumonia, followed by lower proportions with cryptococcal meningitis and bacterial infections. The patients were well enough to give informed consent and to take oral medications, and therefore the findings may not be generalizable to those who are severely unwell or requiring intensive care. Previous observational data suggest a survival benefit for HIV-positive patients who are started on ART while in the intensive care unit [19, 20], but the data are insufficient to make a recommendation in this group [19, 20]. There was no increase in the incidence of immune reconstitution disorders (IRD) or adverse events generally with early ART initiation in ACTG 5164 [1, 5]. However, those with intracranial opportunistic infections may be more prone to severe IRDs with early ART initiation.
DNA band patterns were obtained after gel electrophoresis (08% a
DNA band patterns were obtained after gel electrophoresis (0.8% agarose gel) of the RAPD-PCR reaction products (15 μL). Gels were run for about 55 min at 100 V and stained in ethidium bromide (0.5 μg mL−1) for 30 min. DNA molecular weight marker ('500 bp molecular ladder', Bio-Rad) was used as a standard. Gel
images were processed using the software fingerprinting II (Bio-Rad). The similarity matrix was calculated on the basis of the Pearson product–moment correlation coefficient, and its corresponding dendrogram was deduced using the unweighted pair group method with arithmetic averages [Struelens ABT-888 cost & the Members of the European Study Group on Epidemiological Markers (ESGEM), of the European Society for Clinical Microbiology and Infectious Diseases (ESCMID), 1996].
Reproducibility was assessed by cluster analysis of triplicate reactions. RAPD-based methods do not require sequence information for PCR primer design. However, they are extremely dependent on laboratory conditions such as template DNA concentration, PCR and electrophoretic settings, among others (Ellsworth et al., 1993). To establish a quick and useful RAPD-PCR protocol to type phages, phages infecting strains belonging to the same species (four Staphylococcus epidermidis phages), or different species within the same genus (two Staphylococcus aureus phages) or a different genus (one Lactococcus lactis phage) were selected to test several experimental conditions in order to generate ZD1839 manufacturer reproducible RAPD patterns and gain a preliminary insight into the discrimination power of this approach. The selected S. epidermidis phages belonged to the Siphoviridae family (morphotype B1) and their genome sequences were unknown. However, previous
DNA restriction analysis revealed distinct patterns for the temperate phages ΦSepi-IPLA6 and ΦSepi-IPLA7, while the DNA restriction patterns of the lytic phages ΦSepi-IPLA4 and ΦSepi-IPLA5 (presumably virulent derivatives of ΦSepi-IPLA6) were very similar to each other (Gutiérrez et al., 2010; and our unpublished data). The two phages infecting Flavopiridol (Alvocidib) S. aureusΦH5 and vB_SauS-phiIPLA35 (Φ35) belonged to morphotype B1 and morphotype B2, respectively, and their complete genome sequence was available (García et al., 2007, 2009). Finally, the lytic L. lactis phage ΦC2 belonging to the morphotype B2 (Lubbers et al., 1995) was chosen as representative of phages infecting a different genus within Gram-positive bacteria. Initially, pure phage DNA (10 ng) was used as a template. Because RAPD-PCR reactions are considerably influenced by primers and their concentration (Johansson et al., 1995), four primers (OPL5, RAPD5, P1 and P2) at three different concentrations (1, 4 and 8 μM) were tested. Furthermore, we tested whether the presence of magnesium oxalacetate and DMSO resulted in better defined band patterns.
Depending on their
Depending on their www.selleckchem.com/products/nu7441.html nutritional status, the subjects were categorized, as being 'normal weight,' 'at risk of overweight,'
and 'overweight.' Logistic regression was applied to study the association between the dental indexes and independent variables: gender, age, toothbrushing, nutritional status, and lifestyle factors. Being overweight positively correlated with GI, but negatively correlated with the DMF/dmf index among the participants. Multivariate analysis showed a strong association between the weight category and toothbrushing with GI and PI. Overweight children (6–11 years) were less likely to have caries, whereas in older children/adolescents (12–18 years), caries was associated selleck compound with the intake of sugar-sweetened juices. Being overweight was found to be significantly associated with a higher probability of developing gingivitis and negatively associated with caries prevalence in Serbian children and adolescents. "
"International Journal of Paediatric Dentistry 2012; 22: 369–381 Background. The effect of smear layer (SL) removal on primary tooth pulpectomy outcome has not been well elucidated. Aim. To determine the effect of SL removal on primary tooth pulpectomy outcome. Methods. This
is a double-blind, randomized, and controlled clinical trial. Forty-eight patients were randomly divided into SL removal (G1 = 40 teeth) or smear layer nonremoval (G2 = 42 teeth) groups. Following the chemomechanical preparation with K-files and 2.5% sodium hypochlorite (NaOCl), teeth were irrigated with either
6% citric acid and 0.9% physiologic solution (G1) or only 0.9% physiologic solution (G2). Camphorated paramonochlorophenol crotamiton was used as intracanal medication. At the second appointment, 1 week after, root canals were filled with zinc oxide–eugenol paste. Clinical and radiographical baseline criteria were stipulated equally for both groups. Results. The success rate (G1 = 91.2%; G2 = 70.0%) was statistically different (P = 0.04) between the groups. In G2, the outcome was affected significantly by pulpal necrosis (P = 0.02), pre-operatory symptoms (P = 0.02), and periapical/inter-radicular radiolucency (P = 0.04). Conclusion. The pulpectomy outcome was improved by smear layer removal. The outcome for teeth with pulpal necrosis, pre-operatory symptoms, or periapical/inter-radicular radiolucency was significantly improved by removal of the smear layer. "
"There is a paucity of research examining how children and their families adapt to traumatic dental injuries. This study examined how clinical and psychosocial factors influence adaptation to this oral stressor using a theoretical framework of resiliency and adaptation.
Three independent cultures as well as protein extractions
and 2D-PAGE were performed to assess the reproducibility of the experiment. Gels were stained with Coomassie Brilliant Blue (CBB). CBB staining was carried out according to Neuhoff et al. (1988) with minor modifications and scanned in a Microtek 9800XL densitometer (Microtek) at 300 dpi resolution. Gels were stored in vacuum-sealed plastic bags at 4 °C. pdquestadvance software version 8.0 (Bio-Rad) was used for spot detection and quantitation, and to assess reproducibility. Protein spots chosen for mass spectrometric analysis (MS) were excised from the gels and manually digested. The gel pieces were rinsed three times with AmBic buffer (50 mM ammonium bicarbonate in 50% Natural Product Library HPLC grade methanol (Scharlau, Spain) and once with 10 mM DTT (Sigma-Aldrich). The gel pieces were rinsed
twice with AmBic buffer and dried in a SpeedVac before alkylation with 55 mM iodoacetamide (Sigma-Aldrich) in 50 mM ammonium bicarbonate. Navitoclax mouse Once again, the gel pieces were rinsed with HPLC grade AmBic buffer (Scharlau), before being dehydrated by the addition of HPLC grade acetonitrile (Scharlau) and dried in a SpeedVac. Modified porcine trypsin (Promega) was added to the dry gel pieces at a final concentration of 20 ng μL−1 in 20 mM ammonium bicarbonate, incubating them at 37 °C for 16 h. Peptides were extracted three times by 20 min incubation in 40 μL of 60% acetonitrile in 0.5% HCOOH (formic acid). The resulting peptide extracts were pooled, concentrated in a SpeedVac and stored at −20 °C. A combination of matrix-assisted laser-desorption-ionization time-of-flight mass spectrometry (MALDI-TOF) (MS) and MALDI-TOF/TOF (MS/MS) was used for protein identification according to the following procedure. Dried samples were dissolved
in 4 μL Meloxicam of 0.5% formic acid. Equal volumes (0.5 μL) of peptide and matrix solution, consisting of 3 mg α-cyano-4-hydroxycinnamic acid (CHCA) dissolved in 1 mL of 50% acetonitrile in 0.1% trifluoroacetic acid, were deposited using the thin-layer method onto a 384 Opti-TOF MALDI plate (Applied Biosystems). Mass spectrometric data were obtained in an automated analysis loop using a 4800 MALDI-TOF/TOF analyzer (Applied Biosystems). MS spectra were acquired in reflectron positive-ion mode with an Nd:YAG, 355-nm wavelength laser, averaging 1000 laser shots, and at least three trypsin autolysis peaks were used as internal calibration. All MS/MS spectra were performed by selecting the precursors with a relative resolution of 300 full width at half maximum and metastable suppression. Automated analysis of mass data was achieved using the 4000 Series explorer software V3.5. Peptide mass fingerprinting (PMF) and peptide fragmentation spectra data of each sample were combined through the GPSexplorer Software v3.6 using mascot software v2.1.
Streptococcus suis isolates were examined for their ability to au
Streptococcus suis isolates were examined for their ability to autoaggregate learn more according to the protocol of Basson et al. (2008). Bacteria were grown overnight in THB medium, washed, and resuspended in sterile distilled water to an OD660 nm of 0.3. The degree of autoaggregation of all isolates was determined using the equation: % autoaggregation=(((OD660 nm at T0−OD660 nm at T60 min)/OD660 nm at T0) × 100). OD660 nm was recorded following
a low-speed centrifugation at 400 g for 2 min. Assays were run in triplicate and the means ± SD of three independent experiments were calculated. The relative surface hydrophobicity of S. suis cells was determined by measuring their absorption to n-hexadecane according to the procedure described by Rosenberg et al. (1980). Assays were run in triplicate and the means ± SD of three independent experiments were calculated. The subtilisin-like and dipeptidyl peptidase IV (DPP IV) activities of S. suis cells were measured using the chromogenic substrates succinyl–Ala–Ala–Pro–Phe–p-nitroanilide (p-Na) (Sigma-Aldrich Canada Ltd, Oakville, ON, Canada) and Gly–Pro–p-Na (Sigma-Aldrich
Canada Ltd), respectively. For both proteolytic assays, 100 μL of a cell suspension at OD660 nm=2 (in 50 mM Tris-HCl, pH 8, containing 5 mM CaCl2) was added to 20 μL of substrate (2 mg mL−1 in 50% dimethyl sulphoxide), and the mixtures were incubated at 37 °C for 4 h. The release of p-Na, indicative of substrate C59 wnt ic50 degradation, was determined visually by the appearance Aspartate of a yellow colour. The culture broth medium used to investigate biofilm formation by S. suis contained 0.5% glucose, 2% peptone (Proteose Peptone no. 3, Difco, Detroit, MI), 0.3% K2HPO4, 0.2% KH2PO4, 0.01% MgSO4·7H2O, 0.002% MnSO4·6H2O, and 0.5% NaCl. Biofilm formation was measured in 96-well polystyrene microplates (Nunc-Immuno® MaxiSorp;
Nalge Nunc International) and crystal violet staining as described previously (Grenier et al., 2009). Assays were run in triplicate and the means ± SD of two independent experiments were calculated. The adhesion property of 13 S. suis strains (six of serotype 2 and seven nontypeable) to fibronectin immobilized onto polystyrene plate wells was investigated. The results presented in Table 2 indicate that none of the S. suis strains could adhere to BSA, which was used as a control protein. However, the seven nontypeable isolates of S. suis (1078212, 1079277, 1097925, 1185293, 1148795, 1077009, and 1079506) showed a marked capacity to adhere to the fibronectin-coated surface. Under the conditions used in our study, all strains of S. suis serotype 2 attached poorly to the fibronectin-coated surface. The adherence properties of three nontypeable strains of S. suis were further investigated by evaluating their attachment to brain microvascular endothelial cells. As shown in Fig.
For example, when prehypertensive men and women (mean age 49 year
For example, when prehypertensive men and women (mean age 49 years) were randomized to receive an angiotensin II receptor antagonist (ARB) or placebo for 2 years, hypertension developed in 40% of the placebo recipients, and only 14% of the active drug recipients (66% this website relative risk reduction). When the active drug was discontinued and participants were followed
for an additional 2 years, those who originally received ARB maintained significantly lower systolic (−2 mmHg) and diastolic (−1.1 mmHg) blood pressures, and maintained their lower relative risk for developing hypertension (15%) than the placebo recipients. This suggests that even small decrements in systolic and diastolic blood pressure that can be maintained for prolonged periods can postpone the progression of hypertension. In another cohort study [46], normotensive men and women (<120/80 mmHg) with modest coronary artery disease who controlled their blood pressures using either an angiotensin-converting enzyme inhibitor or a calcium-channel blocker had the largest decrease in coronary atheroma volume (using intravascular ultrasound) after 2 years, while participants with baseline pre-hypertension or hypertension had no significant reduction or an increase in atheroma volume. This suggests that early anti-hypertensive
interventions, even in people with normal blood pressures, effectively reduce the progression of atherogenesis. In HIV-infected people with pre-hypertension and other cardiometabolic risk factors (e.g. tobacco use, Tanespimycin in vitro central adiposity and dyslipidaemia) it seems prudent to recommend lifestyle modifications (including yoga) to reduce blood pressures. Randomized trials and observational studies are consistent in that a 10 mmHg reduction in systolic blood pressure and a 5 mmHg reduction in diastolic blood pressure predict ∼50–60% lower risk for death from stroke,
and ∼40–50% lower risk for death from coronary artery (or other vascular) disease [40,42]. In the current study, average reductions in systolic/diastolic blood pressures were 5/3 mmHg. Assuming that HIV-infected people respond similarly to the general population, our findings suggest that the risk of death from stroke was reduced by 25–30% and the risk of death from coronary artery disease was reduced by 20–25% by this yoga intervention. Pregnenolone Yoga was selected as the intervention because complementary and alternative medicine advocates believe that yoga's approach to synchronizing breath inhalation, exhalation or held breath to movement in conjunction with focusing the mind on a specific region of the body optimizes the interaction between the autonomic nervous system and endocrine system [16,47,48]. We hypothesized that yoga would reduce body fat because energy expenditure during Hatha/Ashtanga yoga averaged 2.5 METS (3 kcal/min) and peak energy expenditure was 11 METS (14 kcal/min) [49,50]; however, fat loss was not observed.
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Impact of Approaches for Protecting against Unhealthy weight and also Risks for Eating Disorders amid Young people: An organized Review.
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Vegfr signal


The CRG has a long experience in coordinating large European collaborative projects and is therefore contributing to advancing knowledge in diverse fields of biology and biomedical research, ranging from systems biology, cancer, epigenetics, cell trafficking, and rare diseases to medical genomics.
The Institute has led a total of eight collaborative projects under the 7th Framework Programme for research and technological development (2007-2013) and now leads five under the Horizon 2020 programme for research and innovation (2014-2020). This section lists the active collaborative projects currently headed by the Institute.
ChromDesign is an innovative and interdisciplinary network of 10 European academic and private institutions. Our aim is to characterise how 3D chromatin organisation affects gene regulation during cellular differentiation and in several human disorders.
The ORION project focuses on triggering evidence-based institutional, cultural and behavioural changes in Research Funding and Performing Organizations (RFPOs), to "embed" Open Science and Responsible Research and Innovation (RRI) principles in their policies, practices and processes.
The goal of the Minicell project is to develop a whole-cell model of the human lung pathogen M. pneumoniae, and use this model to design and construct a reduced, non-pathogenic chassis capable of delivering human lung therapies and/or vaccinations.


Here we have a high quality and potent 100:1 water-soluble extract of the Eurycoma longifolia roots. Tongkat Ali has been shown to restore testosterone levels, lower estrogen and SHBG, boost several parameters of performance in the bed, including erectile function, hardness, performance, and satisfaction, and so much more.
Schisandra is a renown beauty herb in Chinese medicine, which also supports performance in the bed. It also does much more including enhancing mitochondrial glutathione status, other antioxidant activity, ATP generation, cognitive enhancements, and reductions in age-related impairments.
Chaga is king for a reason. It's known in Russia for its anti-cancerous effects. In fact, it was approved as an anti-cancer drug there way back in 1955. Plus it reduces inflammation, is loaded with antioxidants like Super Oxide Dismutase (SOD), Betulin and more. In fact it has many novel compounds which contribute to is DNA protective benefits. I've been taking chaga every single day for months now personally.
Ours is a dual extracted 8:1 chaga extract.
Mucuna pruriens is a natural source of L-dopa, or levodopa, an amino acid that converts into dopamine. Dopamine is an essential part of the brain properly working and can easily be depleted by stress, drug abuse and stimulants. And that's not all. It contains small amounts of serotonin and 5-HTP making it an interesting herb to act as a nootropic.
Further, dopamine may assist in proper hormone levels. In infertile men,mucuna was shown to increase testosterone, lutenizing hormone, dopamine, adrenaline, and noradrenaline while decreasing levels of prolactin and follicle stimulation hormone. L-dopa has been shown to increase growth hormonefor one to two hours after taking it.
Schisandra comes in a 30 gram bag, with a daily dose of 1/4 to 1/2 tsp.
Chaga comes in a 30 gram bag with a daily dose of up to 1/2 tsp.
Mucuna comes in a 30 gram bag with a daily dose of up to 1/4 tsp.


Although most pundits (except me, Mike Burry, M.D.) were predicting either Spotlight, Mad Max or The Revenant to win, The Big Short came up the big surprise at the Producers Guild Awards tonight, along with the expected wins for Amy and Inside Out. What was it that gave some of us hope and cautious confidence? The Big Short is the only film that has SAG Awards Ensemble/ACE Eddie/DGA/PGA and BAFTA nominations. It is well liked across the board, which on paper gives it the advantage. But we didn't know until tonight if this would be the year these reliable stats would fail. So far anyway, it looks like our Oscar model is a solid success. Next up, the SAG Awards on January 30th, and after that the ACE, WGA and DGA.
The Big Short is such a good movie that it may take several viewings to realize just how good it is. Every character is carefully considered and written with a rich blend of flaws and honorable traits. Most films made these days don't take time to construct layered characters the way Adam McKay has done, working with screenwriter Charles Randolph from Michael Lewis's book. Characters so specific that you barely notice it the first time through. There's more than that, of course, driving it through to a win.
This is an election year and Wall Street is front and center. Market manipulations should matter to you whether you're a Bernie supporter, a Hillary supporter, or a supporter of any GOP candidate. People of all political persuasions remain rightfully angry that no one was prosecuted and most of us resent the fact that Wall Street execs, bankers and brokers gambled with our money, lost big time, and still walked away rich with the American taxpayers bailing them out. We should all be angry about that, no matter which party we want to run the country. The Big Short exposes the rigged con-game better than any other movie ever made about Wall Street and, thanks to Michael Lewis's scathing approach, it satirizes the people involved while painting a crystal clear picture of the crazy, conflicted world where we find ourselves ensnared.
The Wolf of Wall Street, in contrast, was about a more ruthless kind of financial thievery — crooks who walk away rich with no conscience and no regrets. The Big Short isn't about those people. It's about a few smart investors who saw the banks were committing fraud and bet against the game on the eve of the housing market crisis. When it became clear that the banks themselves were betting against millions of homeowners, a handful of money managers tried to sound the alarm about the extent of the damage about to rain down. But the rotten foundation inevitably gave way and the Jenga towers began to collapse all around them. The catastrophe left many cocky deal-makers hollowed out and forever changed. There is no forgiveness granted here, nor any real redemption, but there are three-dimensional humans worth caring about. The story works for audiences because people all across the country are angry, but it also works on its own as a brilliantly written, carefully acted and energetically directed American film of the first order.
The Big Short taking the PGA's top honor tonight shows that the Oscar stats we use as our trusty barometers are once again proven valid. At least for now. In such a wide-open race anything can happen. What probably happened with the Producers Guild was that The Revenant and Fury Road may have divided the vote for epic virtuosity. Without either one of these two, the other might have built enough momentum to surpass The Big Short. But with two technically impressive visual epics, all the producers who weren't voting for the more literate dialogue-driven duo — The Big Short or Spotlight — would have their votes split up between two sweeping extravaganzas.
That left another large segment of the guild to choose between Spotlight and The Big Short. Both are films that would be likely to figure prominently in the number one and number two slots on the preferential ballot. But The Big Short has several things that Spotlight doesn't. Perhaps first and foremost it has a greater sense of urgency for voters because it's an election year and people are thinking about politics. Spotlight's issue is of course immensely important, but the movie itself encourages the feeling that child abuse in the Catholic church is matter that, if not fixed, is at least under better control. The Big Short leaves us with no such sense of security. It ends on a note that lets us know this global financial time-bomb is ongoing and may even be poised to blow up all over again. That urgency is certainly part of its appeal. But even without the political component The Big Short might have won because there's such flair in its acting, writing and directing. It's exuberant in a way that Spotlight is not, dynamic in a way that excites people.
There's that final moment in The Big Short when our narrator, Jared Vennett, pulls a last fast one. With a sly grin he says it all turned out for the better: the crooks on Wall Street went to jail, the government instituted strict regulations, and everyone learned a hard lesson. He pauses, and then says: "Just kidding." Then he tells us what really happened, reminding us of the grim reality. That short-circuit verbal jump-cut between what we all know to be true and the way he frames the joke as if he's trying to once again to pull the wool over our eyes is the cinematic moment of the year. There isn't an audience in any town in America that wouldn't react to that, especially a town like LA where everyone with a ballot has a hefty stock portfolio too. So even if The Big Short didn't seem to be generating the kind of extreme passion that The Revenant was getting, it's apparently giving enough voters plenty of meat to chew on. It's well liked by almost everyone and hated by very few.
Does all this mean The Big Short wins Best Picture? It means it just got a really good turbo boost to the head of the pack, and yeah, it could very likely go all the way. I would hold off on saying for sure, though. I would hold off because of the kind of disjointed year it's been. While there isn't really enough time to turn the ship around once the consensus starts to build, with just a few short weeks here before the rest of the guilds weigh in and Oscar ballots about to be sent out, The Big Short just got a lot more attractive as the safest best at the moment to win.
Fun fact: if Adam McKay wins Best Director he will be the first American-born director to win the Oscar since Kathryn Bigelow won in 2009, five long years ago. Fun fact #2: The Big Short and Mad Max:Fury Road are the only two films in the Best Picture race that feature black women in speaking roles. The only two.


text:
Remove Forgery
Remove Loaning to Client
Fraud-Other (1)
Loaning to Client (1)
Misuse of the Marks (1)
Negligence (4)
Revocation of Other Professional License (1)
Unauthorized Use of the Marks (1)
CFP Board (1)
Article 3(f) (3)
Page 1 of 1 , 16 Items in Total
Keyword(s): Misuse of the Marks; Lawsuits Involving Financial Matters; Arbitration; Customer Complaints; Disclosure to Clients; Suitability; Diligence; Professionalism; Misrepresentation
Standard(s) Violated: Article Article 3(a); 607; 601; 201; 704; 606(b); 701; 102
Summary: Whether a CFP® certificant violated CFP Board's Standards of Professional Conduct when he: 1) recommended variable annuities to elderly clients; and 2) omitted the registered trademark symbol when referring to CFP® on his letterhead, certification salutations and documents.
Keyword(s): Diligence; Record-Keeping; Client Neglect; Suitability; Arbitration
Standard(s) Violated: Article 701; 201; Article 3(a)
Summary: Whether a CFP® certificant violated CFP Board's Standards of Professional Conduct when he: 1) implemented an aggressive investment strategy for an elderly client ("Client"); 2) did not inform the Client that she had unrealistic investment expectations; 3) did not review the Client's accounts after implementing the investment; and 4) did not respond to the Client's calls.
Keyword(s): Diligence; Arbitration; Professionalism
Standard(s) Violated: Article Article 3(a); 701; 201; 406
Summary: Whether a candidate for CFP® certification violated CFP Board's Standards of Professional Conduct when he: 1) did not meet with a client ("Client") regarding a discrepancy in the number of checks written from the Client's Cash Management Account, which was later found to involve unlawful activity by the Client's health care aide; and 2) did not bring the matter to his branch manager's attention.
Keyword(s): Outside Business Activity; Misrepresentation; Professional Discipline; Commission/Compensation; Arbitration
Standard(s) Violated: Article 607; Article 3(a); 701; 406; Article 3(e); Article 3(d); 606(a); 606(b); 102; 201; 202; 405
Summary: Whether a CFP® professional ("Respondent") violated CFP Board's Standards of Professional Conduct when he violated: 1) sections of the State Securities Act by selling unregistered securities; 2) the 2004 State Securities Board ("SSB") Undertaking and 2005 SSB Order regarding supervision; 3) the 2004 SSB Undertaking and sections of the State Securities Act by failing to fully complete forms before obtaining client signatures; 4) sections of the State Securities Act by failing to disclose required information on his Form U4 and making material misrepresentations to the State Commissioner; 5) the 2004 SSB Undertaking and 2005 SSB Order by engaging in unsuitable transactions; and 6) National Association of Securities Dealers ("NASD," now known as the Financial Industry Regulatory Authority or "FINRA") Conduct Rules by accepting a gift and/or gratuity in excess of $100 and charging clients both investment advisory fees and prohibited commissions.
Keyword(s): Securities Laws Violation; Supervision; Record-Keeping; Advertising; Misrepresentation; Continuing Education Violation; Diligence; Disclosure to Clients; Professional Discipline
Standard(s) Violated: Article 401(b); 101(a); 705; 701; 401(a); 606(a); Article 3(a)
Summary: Whether a CFP® certificant violated CFP Board's Standards of Professional Conduct when a Financial Industry Regulatory Authority investigation showed that he and his company violated securities laws related to the sale of securities on military bases.
Keyword(s): Arbitration; Securities Laws Violation; Professional Discipline
Standard(s) Violated: Article 606(b); 701; 607; 201; Article 3(a); 406; 606(a)
Summary: Whether a CFP® professional ("Respondent") violated CFP Board's Standards of Professional Conduct when he: 1) corrected a trading error in a client's account by reimbursing the client from his own personal funds, rather than following firm policy with respect to resolving trading errors; and 2) traded a security in his personal securities account ahead of trading the same security in a client's account.
Decision: Granted Petition
Keyword(s): Professionalism; Employer Policy Violation; Misdemeanor; Forgery; Settlement; Diligence
Standard(s) Violated: Article Article 3(a); 102; 606(a); 701; 606(b); 607
Matter Type(s): Other Professional Discipline; Criminal Court
Summary: Whether a CFP® certificant violated CFP Board's Standards of Professional Conduct when he: 1) was convicted of driving under the influence and; 2) was asked to resign from a financial services firm ("Firm") after he photocopied a client's ("Client") signature onto a Firm document.
Keyword(s): Commission/Compensation; Misrepresentation; Conflict of Interest; Loaning to Client; Disclosure to Clients; Securities Laws Violation; Competency; Commingling; Fiduciary Duty; Diligence
Standard(s) Violated: Article 402; 301; 606(b); Article 3(a); 607; 102; 606(a); 103(d); 302; 701; 403
Matter Type(s): CFP Board
Summary: Whether an applicant for reinstatement of his CFP® certification ("Respondent") demonstrated rehabilitation by clear and convincing evidence that he complied with all disciplinary orders and provisions of the Disciplinary Rules and Procedures and is, once again, fit to use the CFP®, CERTIFIED FINANCIAL PLANNER™, and certification marks.
Keyword(s): Forgery; Employer Policy Violation; Outside Business Activity; Fraud Related to Professional Activity; Securities Laws Violation
Standard(s) Violated: Article 606(a); 406; 701; 407(a); Article 3(a); 201; 704; 102; 401(a); 607; 606(b)
Summary: Whether a CFP® professional ("Respondent") violated CFP Board's Standards of Professional Conduct when he 1) failed to provide his firm ("Broker-Dealer") with notice of his involvment in private securities transactions with a managed currency program ("Fund"), in violation of National Association Securities Dealers ("NASD", now known as the Financial Industry Regulatory Authority, Inc. or "FINRA") Conduct Rules 3040 and 2110; 2) recommended and sold investments that were not approved by Broker-Dealer and that were outside the scope of his employment with Broker-Dealer; 3) used an outside email accout to skirt Broker-Dealer's internal controls; 4) informed his clients that the Fund was a safe investment when it was not safe; 5) signed a customer's name to account related documnets without the customer's knowledge or consent at least 16 times, in violation of NASD Conduct Rule 2110; 6) did not disclose his compensation arrangement to clients; 7) did not disclose the referral fees he received for directing clients' investments to the Fund; 8) was suspended by FINRA for violating NASD Conduct Rules 3040 and 2110; and 9) had his securities license revoked by the State Securities Division for failing to respond to the State's Order to Show Cause.
Keyword(s): Professional Discipline; Forgery; Suitability; Securities Laws Violation; Employer Policy Violation; Failure to Notify CFP Board
Standard(s) Violated: Article 606(a); 202; 6.5; 405; 607; 606(b); 201; 701; 406
Summary: Whether a CFP® professional ("Respondent") violated CFP Board's Standards of Professional Conduct when he: 1) sold 20,000 stock put options in SH and YH's account, resulting in a total unrealized loss of $430,000 and a realized loss of almost $2 million; 2) charged SH and YH full commissions on their trades when they should have been entitled to discounted rates based on the size of their investment accounts; 3) charged SH and YH an exorbitant fee of 8% a year; 4) altered the clients' new account forms with White-out, causing Firm to retain and preserve altered records and causing him to be suspended by Financial Industry Regulatory Authority ("FINRA") for violation of firm policy and National Association of Securities Dealers ("NASD") Conduct Rules 2110 and 3110; and 5) failed to report his FINRA suspension within 30 days.

redpajama_set_name: RedPajamaCommonCrawl


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ICYMI: Amina Buddafly And Tara Wallace Are Apparently BFFs Now?
We honestly have NO idea what is going on? We saw that Amina Buddafly posted this picture to her Instagram with Love & Hip Hop rival Tara Wallace and we're all, "WTF?" But then we saw Tara posted a picture of the two on her 'gram right around the same time. Exxxxxcuse me? Are these two besties now? Did they decide to say, "Screw, Peter, let's band together?!" Or were they just at the same holiday party? Twice?
What do you think of Tara and Amina? Budding friendship or a keep-your-friends-close-and-your-enemies-closer sitch? Let us know your thoughts in the comments!


And on the right, one of my 1/600 Xyston ancient vessels, and assorted bits. I am going to take another look at this scale for my Tékumel naval project. One item that I can see already is the size of the 'castle' from Xyston. It seems to be slightly small. A scratch-built replacement might be in order.
I finally purchased my copy, and I am looking forward to reading through it again.
I saw a demo game at a wargames show- probably Kirriemuir (I think) and the game seemed great fun.
I've really enjoyed Galleys and Galleons. They are a very versatile set of rules, play well, not too complex and great value for money.
Thank you, gentlemen. Now I need to get cracking on those ships!
You'll be busy! Those 1/1800 ships look nice. Look forward to seeing how they come out with a spot of paint on them.
I was thinking the same thing as to Tekumel naval gaming. I am behind you on this project, both as moral support, and chronologically. I am actually thinking 6mm scale, using the Hotz paper ships to start.
Les Loups Gris attaquent !
Break out from the camp!
Ion Age Muster and other stuff.
And now, what do you think?
Re-fight: Battle of Coronel 1914 + new sea mat!


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Click the link for the Earth Day content you want, or click inside for more stories. If you have Earth Day stories that would work on a national level, please Zope it to GHNS or email it to national@gatehousenewsservice.com.
Click the link for the Earth Day content you want. If you have Earth Day stories that would work on a national level, please Zope it to GHNS or email it to national@gatehousenewsservice.com.


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At great speed. What you hope to be in any race.
A large motor vehicle that moves things from one place to another along roads.
The absence of color. Snow looks like this!
1. One of the signs or written symbols that we use to write words, such as x, y, and z.
2. A written message that you send to someone or receive from someone by mail.
A thin, plastic tube used for drinking. If you get a drink at a fast food restaurant this will probably be in the cup.
A warm bedding made of two layers of cloth stitched together. It takes a long time to make one of these!
To strike something quickly with your hand or with an object. It is not good to do this to your little brother or sister.
An animal that is a part of your family and lives in your home. This is a fun thing to have and play with.


US Masters brought all that is American 'cross to the line at this year's Masters Cyclocross World Championships. Two-time World Champion Marilyn Ruseckas has returned with the rainbow jersey around her shoulders, and brings us this rider diary of her experiences in the birthplace of cyclocross.
This year Adam and I returned to Belgium to defend my 2010 championship in Mol at the UCI Cyclocross Masters Worlds. Our small team's hard work and training paid off and we came home with the 2011 rainbow jersey and gold medal.
We based ourselves out of Mol, renting an A-frame right next to the race course. It was off-season for this lakeside resort, so it was very inexpensive. We took day trips from there. Everything was only an hour drive or so. The accommodations were very nice with a modern bathroom, plenty of hot water, TV, and a fully equipped kitchen including a fridge for tasty Belgian beer.
There were endless opportunities for good riding from our house, too. Bike paths run along every road and there are maps that detail a numbered bike route system. Non-technical single track trails in the woods and back roads were perfect for our 'cross bikes. We found our way around without any trouble.
On Sunday, January 16, we traveled to Bakel, Netherlands to race in a Dutch National event. There was a field of about 30 women. I started in the last row, had a terrible first lap, but managed to pull off a fifth place finish. I caught and passed so many young, blonde Dutch girls, it gave me great confidence for the next weekend's race. At the start, an official noticed I was wearing a masters worlds skin suit and he asked me about it. When I came through the start-finish every lap, he announced my name and that I was a masters world champion from the United States of America, in Dutch of course!
Despite a last row call up, Adam's race was going great that day, too. Unfortunately, he got a flat tire towards the end of the race. The pit was pretty far away, so the wheel change came slowly, but he was able to finish and get a good workout.
Historical and Modern merge in this scene. Photo courtesy of Ruseckas.
One day we met with our friend, Hugo, who took us on a very cool ride. We rode through an industrial area near Antwerp. We rode to Doel which is mostly abandoned because they are going to dig up the entire town to make a new harbor for shipping. They will take the rubble from Doel and fill in another harbor that is not being used. It is a very controversial issue. In the meantime, graffiti artists have gone to work painting the town. There is a nuclear power plant very close by, adjacent to an antique windmill. It's a very surreal setting.
On the way home we rode through a rural section of farmland. It was a great ride.
The race course at Mol was fun and very challenging. There were lots of tricky sand sections, twisty single track, a set of barriers, a couple of run ups, and a paved start-finish section. My race went off early and I did what we set out to do. I got in a good warm-up and won the race.
Ruseckas and 30-39 Winner Ilona Meter (Ned) after their races. Photo courtesy of Ruseckas.
It was a relief for me when it was over, but Adam still had his race to think about later in the day. He was the only American in his field of 50 guys. Some of the top finishers in his race have won masters national titles all over Europe and masters world titles in other cycling disciplines as well. Adam finished on the lead lap in 30th place.
Thanks to our Belgian friends, Hugo and Paul, for coming to support us at the races!
The next day, we went to watch the elite World Cup in Hoogerheide, Netherlands. It was such a spectacle. We saw lots of friends and racers that we know. The course was very difficult and all our Americans did well.
Ruseckas and husband Whitney at the Vlaams Wielercentrum Eddy Merckx. Photo courtesy of Ruseckas.
On our last day there, we went back to the track where we rode with Filip and met Hugo last year, the Vlaams Wielercentrum Eddy Merckx. This year Hugo was able to ride with us instead of instructing from the sidelines. The track was full to the limit of 100 riders that night, 98 guys and 2 women. It was extremely nerve racking when we first arrived and had to move up on to the track in traffic. Thanks to Hugo for coaching us as we went. Before long, Adam and I got used to it and were hammering around with the rest of the field. If we had a velodrome like that nearby, Seven would have to make us a couple of track bikes!
We don't know when, but we would would like to go back someday.
Thanks to our sponsors, Seven Cycles, NoTubes.com, and Fit Werx, for helping us to achieve our goal!


text:
Q: Problems to use "Mul" and "Mod" operators in Bash I don't understand why in this code
echo "Please, give me two numbers:"
echo 1:
read a
echo 2:
read b
echo "a = $a"
echo "b = $b"

OPT="Sum Sub Div Mul Mod"
 select opt in $OPT; do

if [ $opt = "Sum"  ]; then
 sum=$(echo $a + $b | bc -l)
 echo "SUM is: $sum"

elif [ $opt = "Sub"  ]; then
 sub=$(echo $a - $b | bc -l)
 echo "SUB is: $sub"

elif [ $opt = "Div"  ]; then
  div=$(echo $a / $b | bc -l)
  echo "DIV is: $div"

elif [ $opt = "Mul"  ]; then
  mul=$(echo $a * $b | bc -l)
  echo "MUL is: $mul"

elif [ $opt = "Mod"  ]; then
  mod=$(echo $a % $b | bc -l )
  echo "MOD is: $mod"

else
 clear
 echo "wrong choise"
 exit

fi

done

execute correctly SUM, SUB and DIV, but if I want to do the MUL or MOD operation, it gives me an error:

(standard_in) 1: syntax error
(standard_in) 1: illegal character: ~
(standard_in) 1: illegal character: ~

A: This should work as you expect. You need to escape the * and the %. And you had echo "MOD is $mul":
echo "Please, give me two numbers:"
echo 1:
read a
echo 2:
read b
echo "a = $a"
echo "b = $b"

OPT="Sum Sub Div Mul Mod"
 select opt in $OPT; do

if [ $opt = "Sum"  ]; then
 sum=$(echo $a + $b | bc -l)
 echo "SUM is: $sum"

elif [ $opt = "Sub"  ]; then
 sub=$(echo $a - $b | bc -l)
 echo "SUB is: $sub"

elif [ $opt = "Div"  ]; then
  div=$(echo $a / $b | bc -l)
  echo "DIV is: $div"

elif [ $opt = "Mul"  ]; then
  mul=$(echo $a \* $b | bc -l)
  echo "MUL is: $mul"

elif [ $opt = "Mod"  ]; then
  mod=$(echo $a \% $b | bc -l )
  echo "MOD is: $mod"

else
 clear
 echo "wrong choice"
 exit

fi

done

A: You need to quote the *, otherwise it's expanded by the shell.
    mul=$(echo $a '*' $b | bc -l)

% should be fine unquoted, but for simplicity you can quote all the operators.

redpajama_set_name: RedPajamaStackExchange


text:
Ellen DeGeneres 'to hand out millions of dollars in bonuses' as hit talk show ends
The Ellen DeGeneres Show is set to end in May after 19 years and the host is said to be making sure all staff receive a generous bonus
Kim Kardashian reveals Pete has a 'branding' of her name
Ellen DeGeneres will reportedly shell out millions of dollars in bonuses to staff of The Ellen DeGeneres Show.
The popular talk show has been running since 2003 and is set to come to an end in May with the final episode to air on May 26.
And it's been reported that Ellen, 64, wants to make sure all workers on the show are "taken care of".
A source told New York Post : "Ellen and [production company] Warner Bros. worked together to make sure every person was taken care of.
"It was not even a question for Ellen to cover bonuses … That was very important to her."
While the exact figure wasn't revealed, the source claimed Ellen had been "incredibly generous" throughout her time on the show despite allegations of a toxic culture.
The Ellen DeGeneres Show is coming to an end
Two years ago, the star was rocked by the claims and also provided an on-air apology after several former employees hit out at how they were treated on the show.
It's reported that Ellen has been gifting her employees throughout the final series of the show – the 18th series – with presents including trips, watches and cars.
Deadline reported that as well as the gifts, Warner Bros. revealed plans to extend the health-care coverage of members of staff for up to six months after the show ends.
In a bid to aid further employment prospects, the show's creators have also reportedly set up résumé-building and networking workshops for all staff.
Kylie Jenner makes first public appearance at pal's event since birth of son Wolf
Kanye West 'suspended from Instagram' following latest string of outbursts
The last series of the show is set to welcome a host of A-list celebs, with the likes of Michelle Obama and Channing Tatum set to appear.
Other stars including Serena Williams, Zac Efron and Adam Levine are also set to sit on the sofa for a chat.
Last month, Ellen appeared to accidentally let slip that another Kardashian was pregnant during her interview with pal Kris Jenner.
It followed the birth of Kylie Jenner's new son, Wolf, on February 2.
The final episode will air in May
Kris revealed that she had been at the birth of her grandson, branding it "amazing" and said that she was shocked at how much he looked like his older sister Stormi.
When Ellen quizzed who would be next to give her a grandchild, Kris responded: "I think it would be nice if it was Kendall, right? She's the only one who hasn't had a baby."
Ellen went on to suggest that another of Kris' children was already pregnant as she said: "I think she's not gonna be the 12th though."
Emily Atack eats the same thing everyday and admits she's 'obsessed' with it
Denise Van Outen says she was victim of revenge porn at 15 after ex secretly filmed her
Chris Packham tells of family's terror as he shares moment house is firebombed
Emmerdale's Meena bombshell as she appears in court tonight – leading to Manpreet twist


text:
Wednesday Wines – Episode 56
Episode 56 – 21st April 2021
The Launch of 2013 Louis Roederer, Cristal, Champagne, France
with Jean-Baptiste Lécaillon Chef de Cave & Executive Vice-President
The History of Cristal – A Franco-Russian Alliance
(edited from the Louis Roederer press pack)
In 1876, Russian culture represented the height of sophistication – coloured by an exuberant history, and gloriously triumphant with its decorative arts and architecture. The Russian style of dining replaced the French with its vigour and passion. In 1876, Alexander II turned his back on his father's politics, repealed his unpopular measures and abolished serfdom. Patriotism deepened and nationalism boomed. Alexander II, a great lover of good food, set the exact duration for meals: 50 minutes precisely. In 1876, Louis Roederer was 31. He loved to travel and he also loved Russia. Following in the footsteps of his father, who died six years earlier, Louis Roederer was infatuated by the Russian spirit, and he ensured that the Champagne which bore his name dazzled at every opportunity. His father had raised the profile of the House to become one of the most sought-after at the Imperial Court and in also Russian high society. At that time, almost one bottle in every ten drunk was a Louis Roederer Champagne. Roederer cultivated Russian taste and so a considerable dosage was added to his Champagnes, often exceeding 100 grams of sugar. As a result, Champagne houses often produced sweetened Champagne for the Russian market, dosed with at least 150 g/L and sometimes up to 250 g/L.
In 1876, the Emperor lived lavishly on Champagne, intoxicated by its lively bubbles. No official receptions took place without the French wine, synonymous with celebration and joyousness. He saw to it that he received the best wines, and regularly sent a palace emissary to Reims, and more specifically to the Louis Roederer cellars, to reserve his bottles.
One day in 1876, Alexander II noted to his sommelier that there was nothing to distinguish the Champagne served at his table from the versions sold across the country. On learning of this imperial request, Louis Roederer commissioned a Flemish master glass artisan to create an exceptional crystal bottle with a flat bottom to withstand the pressure. From then on, the Tsar only drank Cristal Champagne in its fine, unique bottles bearing the imperial coat of arms. The presentation of the bottle has barely changed to this day. In 1908, the House was even appointed 'Official Supplier to the Court of His Majesty the Emperor of Russia' by Nicolas II. It provided the imperial court with this exceptional Champagne every year until the Russian Revolution in 1917. The cuvée was then lost for several years before being revived in 1924 in its current form – the only change being the replacement of the original crystal by the less-fragile, white glass.
2013 Louis Roederer, Cristal, Champagne, France (approx. £220.00, the following wine merchants have stock either on the shelves right now or arriving imminently, www.harrods.com, www.hedonism.co.uk, www.thefinestbubble.com, www.selfridges.com, www.fortnumandmason.com).
60% Pinot Noir, 40% Chardonnay: taken from 45 different lieux-dits, one third of each from the Vallée de la Marne, the Montagne de Reims and the Côte des Blancs
Wines vinified in oak: 32%
Malolactic fermentation: 0%
Residual sugar: 8gm/L
Harvest was carried out between 27th September – 15th October,
I wondered if I had lost my way with Cristal over the last handful of releases, perhaps never to return, because I was spoilt many years ago when I had the opportunity of drinking some of the most famous, older vintages ever made of this wine. The wines in the Nineties and early Noughties seemed riper and less stern in their youth than I would have wished for because I always think of this elite wine as a label with great potential and not an early drinker. Of course, I understand that people tend to drink Champagne very young these days so perhaps a change in emphasis was to be expected. I have long accepted that what I consider to be 'classic Cristal' might not happen again and, if that was the case, I would not feel compelled to seek out this wine.
It was, therefore, incredibly encouraging to hear Jean-Baptiste Lécaillon say, unequivocally, that it was an intentional decision to make the wines seem more flattering in their youth, in this period, not least by introducing the soothing tones of oak barrels in the recipe. But, more recently, there has been a gradual shift back to making more structured wines.
So it follows that I am beyond excited to tell you that the 2013 vintage looks to me like it possesses all of the ingredients – shape, style and grandeur – which belong to my beloved Cristals of a bygone era.
Jean-Baptiste compares the 2013 to the 2008, which I must admit I struggle a little with. Some of the stats read the same, but in terms of flavour geometry, they are poles apart. J-B calls the 2013 vintage a "2008 plus" and that I certainly agree with! The average alcohols in 2008 were 10.4% and in 2013 they are 10.6%; the Total Acidity was 8.1g/L in 2008 and it is 8.2g/L in 2013; the pH is 2.93 in 2008 and 3.02 in 2013, acknowledging the warm summer. 2008 was also a 60/40 blend of Pinot Noir and Chardonnay and there is a little more oak present in 2013 with 32% used whereas they only employed 20% in 2008. Finally the malolactic in 2008 was 19% and there was none at all in 2013. While these are indeed similar stats, they are not the same and even if they were the wines would still have radically different tones.
In 2008, Louis Roederer started to change tack. J-B said, "we have turned a page towards haute couture farming, embracing organic and biodynamic techniques". They profess to be a little more laid back and have relaxed their obsession with chasing the so-called 'Roederer House Style'.
This is the second year of organic and biodynamic farming for Cristal giving it more concentration and a heightened sense of the chalky terroir. In the Eighties and Nineties they used to pick Chardonnay first and Pinot Noir second, they now do the reverse, and this allows Chardonnay to gain more concentration and "salinity". Interestingly, this is precisely what they did in the old days and the resulting wines were those that I treasure in my memory.
2013 is a dynamic wine with an exquisite salty and chalky expression on the finish. While the perfume is not as reticent as the palate there is still a mesmerising scent of strict citrus notes and faint nuttiness. There is arresting purity and drive here in fact a sip leaves one out of breath, such is the complexity on offer and the time taken for the palate to compute what is happening.
On the Zoom tasting launch today, there was talk about the perfect drinking window for Cristal being 15-20 years down the track so, in theory, this wine should come on stream between 2028 and 2033. I, for one, would be amazed if this wine started to mellow after such a short period given the majesty of the flavour, the density of the acidity and talcy chalkiness on the finish. I think that this is not only a great vintage for Cristal because it is also a historic vintage given that it harks back to an era when this wine was considered one of the finest sparkling wines on the planet. In 2013, I believe that it has climbed back up the hill to where it belongs. Just please promise me that you won't drink it too early! 19.5+/20 (Drink 2030 – 2055)
https://www.matthewjukes.com/wp-content/uploads/2020/04/afina-jukes-article-thumbs-wednesday-wines.jpg 240 240 Matthew https://www.matthewjukes.com/wp-content/uploads/2016/10/Matthew-Jukes-logo-70.png Matthew2021-04-21 04:36:552021-04-20 17:54:49Wednesday Wines – Episode 56
Wednesday Wines – Episode 55 Wednesday Wines – Episode 57 – Two Remarkable Rosés & a host...


Captain Marvel and Avengers 4 Footage Reveals Huge Leadership Shakeup Among Avengers!
Right now Barcelona, Spain is hosting CineEurope and it has been confirmed by The Hollywood Reporter that footage from Captain Marvel and Avengers 4 was shown to attendees.
The Avengers 4 footage wasn't glamorous according to a report from MCU Cosmic. They described it as a custome made video for the attendees with Kevin Feige sitting in a chair apologizing to attendees for cutting down their hero roster. It was supposed to be funny and make the viewers laugh. However, Feige did hint that the remaining Avengers will need to team up once again in order to take on Thanos.
If this is true it gives us a pretty big clue as to the direction Feige and Marvel Studios will be taking the Marvel Cinematic Universe after Avengers 4. It also seems to confirm the rumblings indicating Captain Marvel would be playing a much larger role moving forward. It would also see a leadership shakeup with Carol Danvers possibly filling in for Captain America or Iron Man moving forward.
Along with the Captain Marvel and Avengers 4 footage, Marvel Studios also showed off some scenes from Ant-Man and The Wasp. MCU Cosmic reports there were three clips in total and they highlight the family tone of the film, action, and humor.
Captain Marvel is expected to be released next March 8th. With Avengers 4 following two months later with a released date of May 3, 2019.
Which movie are you looking forward to seeing the most? And how do you think Captain Marvel will change the Marvel Cinematic Universe?


We had the loveliest Thanksgiving this year with sweet friends. It was so wonderfully low-key: two couples, two babies, and an awful lot of laughter. I brought two pies and whipped cream, and Eric made us American Trilogies. I gave mine a hearty douse of Martinelli's because I am a lightweight, and it turned out to be delicious. Huzzah!
It was so much fun to watch our sweet boys play together (entirely peaceably!) We ate in shifts and shared with Micah. He was a huge fan of everything, but most especially the stuffing.
Carmen and Jason have been friends with Eric since freshman year in college, long before my entry onto the scene, and I am so happy they live so close to us. They are five-star human beings, those two (three!) We took this picture with the timer on my iPhone, and, well, you can see four of six people's faces, which is slightly more than half, except that the two missing faces are cuter than the other four of us combined.
This is what our adorable baby looked like this year.
And this was last year (2014), at 3 months, wearing his uncle's dressy outfit. Let's go further down Thanksgiving memory lane!
The year before that (2013), I was 5 weeks pregnant, and as soon as we arrived at Hillary's house, Maggie and Rosie ran out to the car and said, "We invited your baby to Thanksgiving!!" It was the sweetest thing ever.
The year before that (2012), Eric and I had a little Thanksgiving at home, just the two of us. Eric made quail. And I made this crazy pie!
The year before that (2011), we were newlyweds. Eric made Cornish game hens with lavender (so good!), and I appear to have made a cranberry apple crisp.
The year before that (2010), we were engaged and spent Thanksgiving with my whole family at Sea Ranch, in a house that backed up to a rotating sheep pen. It was awesome.
The year before that (2009), we were also at Sea Ranch with my family. Awesome again. Or rather, awesome for the first time.
The year before that (2008), we both stayed in Berkeley and hosted Thanksgiving together for our friends at my apartment. I made this crazy pumpkin stew in a pumpkin thing that required three days of work and is still a running joke. My exhaustion is evidenced by my shirt being on inside out!
It was our first Thanksgiving together, and we were still celebrating every month anniversary of dating. Sweet kids. Seven Thanksgivings later…I'd like to say we love each other just as much…but the truth is that we love each other even more.
I believe my mom's unsurpassable awesomeness has been well-documented here, and thus the reader can imagine what euphoria came over me when she mentioned a few months ago that she ought to come out and see me. And help me with the baby. What?! I love my precious child as boundlessly as the universe is expanding, but sometimes it is difficult not having family in town. But this visit was a double gift–not only would she come and Mary Poppins her way through our apartment and daily routines, but she would also fill them with wit and laughter. She can't help it. She's just contagiously fun.
AND she offered to keep the baby so Eric and I could go on a little getaway to Palm Springs! Our first one since before he was born. But first she spent a few days here with us. I wish I had taken more pictures, but sometimes it is difficult to wrangle a camera and an inquisitive toddler. I am just happy I have the ones I do.
We went to all the thrift stores. Of course.
We went exploring at the San Gabriel Mission and Historic District. We cooked, we cleaned, we drank cocktails and ate enormous pastries. And we talked about everything under the sun.
And then it was time for Mommy and Daddy to hit the road so Mimi and Micah could party it up on their own. Did we worry? Not one tiny bit. Did they have a raucous good time? Yes, yes, they did!
When we came home, we learned that not only had my mom taken care of Micah, but she had swept and mopped our kitchen floor. And she had taken out our stovetop rings and scrubbed them. And she had scoured our sink. And she had taken Micah to TJ Maxx to get a linen basket for his train set, which was previously residing in an Amazon box on the living room floor. And she had loaded the baby up in the car and taken him to a park I've never even been to. And Eric and I had been away for only a little more than 24 hours. Do you see what I mean about both angel and saint?
The thing about my mom is that she is the most can-do person I have ever met in my life. She is endlessly giving, incomparably generous, and always willing to do just about any kindness for just about anyone. And she will also make you laugh while doing it. Do you have some annoying thing in your life that you have never even dared to consider solvable? She will roll up her sleeves and get right to it. Can't get the baby to nap? No problem. Can't figure out how to get your towels to stop smelling? She's on it. Can't keep your shoddy Ikea furniture from falling apart? She will fix it. Or buy you a new one. Before she came, I actually told her, "Mom, be on the lookout for things that can be made better, either in our apartment or in our routine." Sometimes we assume that our little niggling annoyances can't be overcome, but my mom? She will find a way to overcome them. It's amazing (and horrifying!) the things we don't really see because we see them every day. And it's amazing and wonderful what a fresh eye and a helping hand can accomplish in just a few short days.
What did she do while she was here? Helped me find a Kindermusik class for Micah. Looked up YouTube videos about how to unclog my drain. Tried to do it herself with my Walgreens screwdriver (sorry, mom). Helped me figure out how to better ventilate the bathroom. Folded laundry, washed dishes, changed diapers, sang songs, chopped vegetables. All while playing with the baby. I DID NOT KNOW THIS WAS POSSIBLE. That probably sounds a little ridiculous, but there were so many things I wouldn't have attempted to do while Micah was awake that are actually so very do-able. Now I feel so much more productive during the days when we are at home, and our home is so much nicer! It has been revelatory. Just revelatory.
What have I done since my mom was here? Taken apart the tub and sink drains to unclog them. Washed all our towels in vinegar (and then in detergent). Dusted the baby's room and sorted his clothes, putting the ones that are too small (sob!) in storage. Deep cleaned the bathrooms and soaked the faucets in vinegar to remove the lime scale. Researched a bunch of toddler Montessori activities I can do with Micah. Established a family cleaning night (Tuesday!) And I am totally going to re-caulk our tub this weekend.
None of this is really about cleaning, though, or baby activities. It's about recognizing that if something is bothering me, I can fix it. It's about discovering the exhilarating and empowering endorphins of constantly accomplishing little things that add up to so much more. It's about laughing a little more, enjoying life a little bit more. And none of this would have happened without my mom. Who is both angel and saint. What can you say to such a person? Only thank you, and thank you, and thank you again.


text:
#pragma once

bool hijack_ref();

bool hijack_unref();

redpajama_set_name: RedPajamaGithub


Wendroff & Associates is based in Arlington, Virginia. We are a full-service Certified Public Accounting firm with expertise in both business and individual tax preparation, CFO Consulting, and bookkeeping and accounting services. Our passion and specialty is helping small businesses and nonprofits grow and succeed.
Looking for an Arlington VA Accounting Firm? Wendroff & Associates is a full-service Certified Public Accounting firm with expertise in both business and individual tax preparation, CFO Consulting, and bookkeeping and accounting services. Our passion and specialty is helping small businesses and nonprofits grow and succeed.
Our firm prides itself on our level of technological advantages and innovative company culture to provide the best and most personalized service to our Arlington clients. We take time to develop relationships with our clients so we can earn the role as their Trusted Advisor.
At Wendroff & Associates Accounting Firm, one principle guides all others — be proactive and exceed the client's every expectation as the business owner's most trusted adviser. We know being an entrepreneur is risky, everything is on you to fail or succeed. But make no mistake — entrepreneurs are the most important people to the Arlington economy. They birth the new and they create opportunity. And we cherish the opportunity to support their mission.


text:
Champ ist eine Gemeinde mit dem Status "Village" im St. Louis County im US-Bundesstaat Missouri. Das U.S. Census Bureau hat bei der Volkszählung 2020 eine Einwohnerzahl von 10 ermittelt.

Geographie
Die Koordinaten von Champ liegen bei 38°44'37" nördlicher Breite und 90°27'5" westlicher Länge.
Nach Angaben der United States Census 2010 erstreckt sich das Stadtgebiet von Champ über eine Fläche von 2,10 Quadratkilometer (0,81 sq mi). Champ grenzt im Norden an Bridgeton uns im Süden an Maryland Heights.

Bevölkerung
Nach dem United States Census 2010 lebten in Champ 13 Menschen verteilt auf sechs Haushalte und drei Familien. Die Bevölkerungsdichte betrug 6,2 Einwohner pro Quadratkilometer (16,0/sq mi).

Die Bevölkerung setzte sich 2010 aus 100 % Weißen zusammen. Von den sechs Haushalten lebten in 16,7 % Kinder unter 18, 50 % der Einwohner waren Verheiratet und die durchschnittliche Personenzahl pro Haushalt lag 2010 bei 2,17.
Von den 13 Einwohnern waren 15,4 % unter 18 Jahre, 7,7 % zwischen 18 und 24 Jahren, 23,1 % zwischen 25 und 44 Jahren, 30,8 % zwischen 45 und 64 Jahren und in 23,1 % der Menschen waren 65 Jahre oder älter. Das Durchschnittsalter betrug 57,5 Jahre und 53,8 % der Einwohner waren männlich.

Belege

redpajama_set_name: RedPajamaWikipedia


text:
GOP's Vague New Tax Plan Can't Hide True Aim: Massive Tax Cuts for Wealthy
New tax framework released by Trump and congressional Republicans follows long legacy of "plutocrats" offering "lower taxes and deregulation"
Jake Johnson, staff writer
U.S. Speaker of the House Rep. Paul Ryan (R-WI) (L) and Senate Majority Leader Sen. Mitch McConnell (R-KY) (R) speak to members of the media in front of the West Wing of the White House February 27, 2017 in Washington, DC. (Photo by Alex Wong/Getty Images)
With the nation's attention fixed on the Senate GOP's attempts to repeal the Affordable Care Act, House Speaker Paul Ryan (R-Wis.), several congressional Republicans, and two White House aides—who together make up a group called the "big six"—unveiled on Thursday an outline of their tax objectives that critics argued is so vague that it obscures their real aim: to slash taxes for the wealthiest Americans.
"The statement of the big six today revealed little about their true intentions, which is to craft a plan that will give massive tax breaks to millionaires and wealthy corporations at the expense of the middle class and working families," said Frank Clemente, executive director of Americans for Tax Fairness. "As we know from the Republican budget proposals, the tax cuts will mostly be paid for by cutting Social Security, Medicare, Medicaid, education and other critical services."
Statement is where you'd expect GOP to be on 1st day of Congress. "we want tax cuts of some kind to be named later" https://t.co/uBx48Qzz6U
— David Dayen (@ddayen) July 27, 2017
The "big six"—which includes Ryan, Senate Majority Leader Mitch McConnell (R-Ky.), Rep. Kevin Brady (R-Texas), Sen. Orrin Hatch (R-Utah), National Economic Council director Gary Cohn, Treasury Secretary Steve Mnuchin—has reportedly been working "feverishly" to show some kind of progress on their tax agenda as the Senate GOP's healthcare efforts face fierce opposition.
"As we know from the Republican budget proposals, the tax cuts will mostly be paid for by cutting Social Security, Medicare, Medicaid, education and other critical services."
—Frank Clemente, Americans for Tax FairnessThough Ryan and company claim their vague plan to lower tax rates "as much as possible" will lift workers and small businesses while boosting economic growth, analysts have argued that in reality their agenda would deepen American's inequality crisis, which is the worst in the industrialized world.
As Common Dreams reported earlier this month, the few concrete tax proposals put forth by the Trump administration thus far would give "astonishing" tax breaks to the wealthiest Americans while raising taxes on many middle class families.
And as critics have frequently pointed out, the Trump administration's—and the GOP's—tax agenda cannot be separated from its goal of repealing Obamacare.
A report published by Maplight on Thursday found that Trump's cabinet stands to benefit greatly from eliminating the taxes on the wealthy that are central to the Affordable Care Act.
After examining the financial disclosure forms of top Trump administration officials, Maplight concluded: "the repeal of a 3.8 percent tax on investment income—used to fund subsidies that provide health coverage to roughly 10 million low- and middle-income Americans—would have saved Trump and his top two dozen officials between $3.1 million and $7.8 million, leading to an average tax reduction ranging from $124,200 to $313,700."
Writing for the Project Syndicate, economist Joseph Stiglitz argues that the Trump administration and congressional Republicans are following a long legacy of "right-wing plutocrats" who always offer the same solution: "lower taxes and deregulation."
"Donald Trump is counting on this package to make America great again. It won't, because it never has," Stiglitz concludes. "When Ronald Reagan tried it in the 1980s, he claimed that tax revenues would rise. Instead, growth slowed, tax revenues fell, and workers suffered. The big winners in relative terms were corporations and the rich, who benefited from dramatically reduced tax rates."
Our work is licensed under a Creative Commons Attribution-Share Alike 3.0 License. Feel free to republish and share widely.
'Pure Sadism': Biden Blasted for Continuing Trump's Recognition of Guaidó Coup Regime and Deadly Sanctions in Venezuela
Paul Ryan, Mitch McConnell, Donald Trump, Inequality, Joseph Stiglitz, Affordable Care Act
(Click to see more comments or to join the conversation)
'Now Let's Cancel Them,' Demands AOC as Biden Extends Pause on Student Loan Payments


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