text:
Lu 11:1-13. THE DISCIPLES TAUGHT TO PRAY.
1. one, &c.--struck with either the matter or the manner of our Lord's prayers.
as John, &c.--From this reference to John, it is possible that disciple had not heard the Sermon on the Mount. Nothing of John's inner teaching (to his own disciples) has been preserved to us, but we may be sure he never taught his disciples to say, "Our Father."
2-4. (See on Mt 6:9-13).
3. day by day, &c.--an extension of the petition in Matthew for "this day's" supply, to every successive day's necessities. The closing doxology, wanting here, is wanting also in all the best and most ancient copies of Matthew's Gospel. Perhaps our Lord purposely left that part open: and as the grand Jewish doxologies were ever resounding, and passed immediately and naturally, in all their hallowed familiarity into the Christian Church, probably this prayer was never used in the Christian assemblies but in its present form, as we find it in Matthew, while in Luke it has been allowed to stand as originally uttered.
5-8. at midnight . . . for a friend is come--The heat in warm countries makes evening preferable to-day for travelling; but "midnight" is everywhere a most unseasonable hour of call, and for that very reason it is here selected.
7. Trouble me not--the trouble making him insensible both to the urgency of the case and the claims of friendship.
I cannot--without exertion which he would not make.
8. importunity--The word is a strong one--"shamelessness"; persisting in the face of all that seemed reasonable, and refusing to take a denial.
as many, &c.--His reluctance once overcome, all the claims of friendship and necessity are felt to the full. The sense is obvious: If the churlish and self-indulgent--deaf both to friendship and necessity--can after a positive refusal, be won over, by sheer persistency, to do all that is needed, how much more may the same determined perseverance in prayer be expected to prevail with Him whose very nature is "rich unto all that call upon Him" (Ro 10:12).
9-13. (See on Mt 7:7-11.)
13. the Holy Spirit--in Matthew (Mt 7:11), "good gifts"; the former, the Gift of gifts descending on the Church through Christ, and comprehending the latter.
Lu 11:14-36. BLIND AND DUMB DEMONIAC HEALED--CHARGE OF BEING IN LEAGUE WITH HELL, AND REPLY--DEMAND OF A SIGN, AND REPLY.
(See on Mt 12:22-45.)
14. dumb--blind also (Mt 12:22).
20. the finger of God--"the Spirit of God" (Mt 12:28); the former figuratively denoting the power of God, the latter the living Personal Agent in every exercise of it.
21, 22. strong man--meaning Satan.
armed--pointing to all the subtle and varied methods by which he wields his dark power over men.
keepeth--"guardeth."
his palace--man whether viewed more largely or in individual souls--how significant of what men are to Satan!
in peace--undisturbed, secure in his possession.
22. a stronger than he--Christ: Glorious title, in relation to Satan!
come upon him and overcome him--sublimely expressing the Redeemer's approach, as the Seed of the woman, to bruise the Serpent's head.
taketh from him all his armour--"his panoply," "his complete armor." Vain would be the victory, were not the means of regaining his lost power wrested from him. It is this that completes the triumph and ensures the final overthrow of his kingdom. The parable that immediately follows (Lu 11:24-26) is just the reverse of this. (See on Mt 12:43-45.) In the one case, Satan is dislodged by Christ, and so finds, in all future assaults, the house preoccupied; in the other, he merely goes out and comes in again, finding the house "EMPTY" (Mt 12:44) of any rival, and all ready to welcome him back. This explains the important saying that comes in between the two parables (Lu 11:23). Neutrality in religion there is none. The absence of positive attachment to Christ involves hostility to Him.
23. gathereth . . . scattereth--referring probably to gleaners. The meaning seems to be, Whatever in religion is disconnected from Christ comes to nothing.
27, 28. as he spake these things, a . . . woman of the company--of the multitude, the crowd. A charming little incident and profoundly instructive. With true womanly feeling, she envies the mother of such a wonderful Teacher. Well, and higher and better than she had said as much before her (Lu 1:28, 42); and our Lord is far from condemning it. He only holds up--as "blessed rather"--the hearers and keepers of God's word; in other words, the humblest real saint of God. (See on Mt 12:49, 50.) How utterly alien is this sentiment from the teaching of the Church of Rome, which would excommunicate any one of its members who dared to talk in the spirit of this glorious saying! (Also see on Mt 12:43.)
29-32. (See on Mt 12:39-42.)
33-36. (See on Mt 5:14-16; Mt 6:22, 23.) But Lu 11:36 here is peculiarly vivid, expressing what pure, beautiful, broad perceptions the clarity of the inward eye imparts.
Lu 11:37-54. DENUNCIATION OF THE PHARISEES.
38. marvelled, &c.--(See Mr 7:2-4).
39-41. cup and platter--remarkable example of our Lord's way of drawing the most striking illustrations of great truths from the most familiar objects and incidents of life.
ravening--rapacity.
40. that which is without, &c.--that is, He to whom belongs the outer life, and right to demand its subjection to Himself--is the inner man less His?
41. give alms . . . and . . . all . . . clean--a principle of immense value. As the greed of these hypocrites was one of the most prominent features of their character (Lu 16:14; Mt 23:14), our Lord bids them exemplify the opposite character, and then their outside, ruled by this, would be beautiful in the eye of God, and their meals would be eaten with clean hands, though never so fouled with the business of this worky world. (See Ec 9:7).
42. mint . . . rue, &c.--rounding on Le 27:30, which they interpreted rigidly. Our Lord purposely names the most trifling products of the earth, as examples of what they punctiliously exacted the tenth of.
judgment and the love of God--in Mt 23:25, "judgment, mercy, and faith." The reference is to Mic 6:6-8, whose third element of all acceptable religion, "walking humbly with God," comprehends both "love" and "faith." (See on Mr 12:29; Mr 12:32, 33). The same tendency to merge greater duties in less besets us still, but it is the characteristic of hypocrites.
these ought ye, &c.--There is no need for one set of duties to jostle out another; but of the greater, our Lord says, "Ye ought to have done" them; of the lesser, only "ye ought not to leave them undone."
43. uppermost seats--(See on Lu 14:7-11).
greetings--(See on Mt 23:7-10).
44. appear not, &c.--As one might unconsciously walk over a grave concealed from view, and thus contract ceremonial defilement, so the plausible exterior of the Pharisees kept people from perceiving the pollution they contracted from coming in contact with such corrupt characters. (See Ps 5:9; Ro 3:13; a different illustration from Mt 23:27).
46. burdens grievous, &c.--referring not so much to the irksomeness of the legal rites (though they were irksome, Ac 15:10), as to the heartless rigor with which they were enforced, and by men of shameless inconsistency.
47, 48. ye build, &c.--Out of pretended respect and honor, they repaired and beautified the sepulchres of the prophets, and with whining hypocrisy said, "If we had been in the days of our fathers, we should not have been partakers with them in the blood of the prophets," while all the time they "were witnesses to themselves that they were the children of them that killed the prophets" (Mt 23:29, 30); convicting themselves daily of as exact a resemblance in spirit and character to the very classes over whose deeds they pretended to mourn, as child to parent.
49-51. said the wisdom, &c.--a remarkable variation of the words in Mt 23:34, "Behold I SEND." As there seems plainly an allusion to ancient warnings of what God would do with so incorrigible a people, so here Christ, stepping majestically into the place of God, so to speak, says, "Now I am going to carry all that out." Could this be other than the Lord of Israel in the flesh?
50. all . . . required of this generation--As it was only in the last generation of them that "the iniquity of the Amorites was full" (Ge 15:16), and then the abominations of ages were at once completely and awfully avenged, so the iniquity of Israel was allowed to accumulate from age to age till in that generation it came to the full, and the whole collected vengeance of Heaven broke at once over its devoted head. In the first French Revolution the same awful principle was exemplified, and Christendom has not done with it yet.
prophets--in the New Testament sense (Mt 23:34; see 1Co 12:28).
51. blood of Zacharias--Probably the allusion is not to any recent murder, but to 2Ch 24:20-22, as the last recorded and most suitable case for illustration. And as Zacharias' last words were, "The Lord require it," so they are warned that "of that generation it should be required."
52. key of knowledge--not the key to open knowledge, but knowledge, the only key to open heaven. In Mt 23:13, they are accused of shutting heaven; here of taking away the key, which was worse. A right knowledge of God's Word is eternal life (Joh 17:3); but this they took away from the people, substituting for it their wretched traditions.
53, 54. Exceedingly vivid and affecting. They were stung to the quick--and can we wonder?--yet had not materials for the charge they were preparing against Him.
provoke him, &c.--"to harass Him with questions."

redpajama_set_name: RedPajamaCommonCrawl


Archives of Clinical Infectious Diseases - Is <i>Propionibacterium acnes</i> a Causative Agent in Benign Prostate Hyperplasia and Prostate Cancer?
Is Propionibacterium acnes a Causative Agent in Benign Prostate Hyperplasia and Prostate Cancer?
To Cite: Dadashi M, Eslami G, Taghavi A, Goudarzi H, Hajikhani B, et al. Is Propionibacterium acnes a Causative Agent in Benign Prostate Hyperplasia and Prostate Cancer?, Arch Clin Infect Dis. 2018 ; 13(3):e58947. doi: 10.5812/archcid.58947.
Background: Prostate cancer (PCa) is the most common cancer and the second cause of death among men worldwide. Recent documents have disclosed that chronic inflammation can be a major risk factor for PCa. Based on recent studies, the presence of Propionibacterium acnes (P. acnes) as an anaerobic gram-positive bacterium in prostate tissue can be a predisposing factor for PCa. The aim of this study was to evaluate the P. acnes presence in patients with PCa compared to patients with benign prostatic hyperplasia (BPH).
Methods: In a descriptive study that was conducted from January 2015 to December 2016, 95 paraffin-embedded prostate tissue samples (57 PCa and 38 BPH) were evaluated. All samples were collected from the pathology unit of a hospital. DNA was extracted with an extraction kit (GeneAll, Korea) and then PCR was carried out using specific primers for P. acnes. Sequencing was performed on the PCR products to confirm the presence of P. acnes. Demographic data were analyzed using statistical package for social sciences (SPSS) software (version 21).
Results: Out of 95 patients, 57 (60%) were patients with PCa and 38 (40%) were patients with BPH. 39 (41%) and 22 (23%) samples were P. acnes positive in cancer and BPH groups, respectively.
Conclusions: The results suggest that the spread of P. acnes in males with PCa may be common. This finding reflects the possible role of P. acnes in the carcinogenesis of PCa. P. acnes infection may play a relative role in the pathogenesis of PCa or it could facilitate the PCa progression.
Prostate cancer (PCa) is one of the most common cancers among men in the world (1, 2). In 2012, more than one million men suffered from prostate cancer worldwide (3). Among Iranian men, gastric cancer and prostate cancer are the first and second most common cancers, respectively (4). Chronic inflammation is an important risk factor, which can increase the chance of developing prostate cancer in individuals (5). It has been suggested that bacterial infections by inducing long-term inflammation can facilitate cancer development (6, 7). Some studies showed a significant correlation between the presences of Propionibacterium acnes (P. acnes) and inflammation in prostate tissue. P. acnes is an anaerobic Gram-positive ubiquitous bacterium and is a member of skin normal flora. This bacterium has four main types IA, IB, II, and III based on DNA sequence comparison of the recA or tly genes (8). P. acnes can be unambiguously implicated in a variety of manifestations including sarcoidosis, systemic infections folliculitis, and chronic inflammatory (9, 10). Furthermore, some byproducts of P. acnes such as free fatty acids produced as a result of the metabolism of triglyceride can annoy the enforce inflammation through immune cells chemotaxis to the site of infection (11). Some recent research has reported the high incidence of P. acnes in prostate tissue samples of patients with PCa (12-15). These studies have shown that P. acnes has the ability to annoy the cells of the prostate tissue to secret Interleukin 6 (IL-6) and Chemokine (C-X-C motif) (16, 17). In addition, a number of other studies assert that chronic and acute inflammation has been associated with the presence of P. acnes in prostate tissue (13). Some investigations show the transformation of prostate cells after being infected with P. acnes, supporting the hypothesis that P. acnes is a predisposing factor in P. acnes development (14-18). Since there is no evidence of the prevalence of P. acnes in prostate tissue in Iran, in the present study, we sought to investigate the presence of P. acnes strains in prostate tissue samples from men with PCa and benign prostate hyperplasia (BPH) who referred to shohada-ye tajrish hospital of Shahid Beheshti University of Medical Sciences, Tehran, Iran in 2016.
This descriptive study was conducted from January 2015 to April 2016. In this survey, 57 prostate cancer (PCa) and 38 BPH (as a control group) paraffin-embedded tissue blocks were evaluated. Microscopic evaluation to determine the cancerous and non-cancerous tissues and differentiation between PC and BPH was done by a pathologist. The best paraffin-embedded block containing suitable tissues of the patients were selected for examination. In order to further analysis, the samples were transported to the department of microbiology, Shahid Beheshti University of Medical Sciences.
DNA was extracted from paraffin-embedded tissue blocks by G-spin TM total DNA extraction Kit (GeneAll, Korea). First, the paraffin blocks were sliced into thin pieces using a sterile razor bladder and placed in a 1.5-mL tube (not more than 25 mg). According to the manufacturer's instruction, xylene was used to remove paraffin and then the bacterial DNA was extracted from the tissue. After measuring their concentration, the extracted DNA was stored at -20 °C.
PCR was used to evaluate the successfulness of DNA extraction using the human beta-actin gene as the target. In the next step, the second PCR assay was done for the detection of P. acnes using the recA specific primers. The PCR reaction mixture contained 12.5 µL of PCR mix, 1 µL of each primer, and 5 µL of DNA template. PCR grade water was added to bring the final volume to 25 µL. For negative and positive controls, 5 µL of PCR grade water and 5 µL positive controls (P. acnes ATCC 11828) were added, respectively. The specific primers for recA detection were recA F-5'AGCTCGGTGGGGTTCTCTCATC3' and recA R-5'GCTTCCTCATACCACTGGTCATC 3'. PCR conditions are summarized in Table 1. The PCR products were analyzed on 1.5% agarose gel. The gel was stained with ethidium bromide (0.5 µg/mL) and viewed by UV transilluminator. The presence of 1201 bp fragments indicated positivity for P. acnes.
Demographic data were analyzed using Statistical Package for Social Sciences (SPSS) software (version 21).
Most of the patients with PCa belonged to the 70 - 79 age group (29.8%) whereas 50% of the patients with BPH were 50 - 59 years-old. The characteristics of the study patients and Gleason score of tumors are summarized in Tables 2 and 3. In 3.2% of the patients, the Gleason score was 10 (the highest score). Most patients had a Gleason score of seven (33.3%). Chart 1 and 2 represent the frequency of P. acnes in the case and control groups based on age.
Out of 95 study patients, there were 57 and 38 patients with PCa and BPH, respectively. All tested specimens were positive for the beta-actin gene and showed PCR product bands on 1.5% agarose gel. Therefore, all specimens had suitable DNA for the next step PCR. Among the 95 samples, P. acnes was detected in 61 (64.2%) patients. Of 57 PCa specimens, 39 (68.4%) P. acnes positive specimens were detected. 22 (57.9%) specimens in the BPH group were P. acnes positive, as well. No significant relationship was observed between the presence of P. acnes and the age of patients with PCa and BPH (P = 0.25 and 0.84, respectively). The results of this study showed that there was no significant difference between the case group (prostate cancer) and the control group (non-cancerous samples) regarding the frequency of P. acnes (P-value > 0.05). In addition, there was no significant relationship between patients with PCa and control groups in terms of clinical symptoms, stage of tumor progression, tumor type, tumor region in PCa pathological degree, and age (P > 0.05).
Prostate cancer is one the most relevant cancers and a leading cause of morbidity and mortality among men worldwide (19, 20). In Iran, there are no accurate data about the incidence of prostate cancer, but it is estimated that around 90,000 new cases of cancer are reported annually, of which 12 per 100000 cases are prostate cancer (21). The presence of P. acnes was strongly correlated with chronic inflammation, suggesting that this bacterium may have a potential role in cancer development (22). Until now, there are scarce studies conducted to evaluate the prevalence of P. acnes in PCa or BPH. As far as we know, there is no exact data about this issue reported from Iran. Therefore, we investigated the possible role of P. acnes in PCa and BPH using PCR standard methods. Based on the results of the present study, 68.4% of the PCa tissue samples contained P. acnes DNA. About 58% of the BPH tissue samples as the control group were positive for this bacterium, too. Although the positive rate was higher in PCa than in BPH specimens, there was no statistical significance between these differences. This may be due to that we could not use healthy tissue samples as the control group. Investigators showed the role of chronic or recurrent inflammatory processes in the progression of BPH and prostate cancer (23, 24). The high rate of positive results for P. acnes in BPH tissues may consider this bacterium as a predisposing factor for BPH, as well as PCa. Cohen et al. in 2005 showed the presence of P. acnes in one-third of PCa tissue samples as the most common detected microorganism (25). By using fluorescence in situ hybridization, another study in 2007 reported the presence of P. acnes in 50% of the radical prostatectomy specimens (26). P. acnes was the most commonly cultured microorganism (17%) from prostate samples in the study performed by Sfanos et al. (24). Unequal tissue sample size and difference in bacterial detection methods may explain the discrepancy between the results of different studies. Similar to the current study, Davidsson et al. evaluated the relationship between P. acnes and PCa on 100 cancerous and 50 non-cancerous samples by standard PCR. Based on the results of this study, the prevalence of P. acnes in patients with PCa and control group was 60% and 26%, respectively, which indicates a high prevalence of P. acnes in the cancer group compared to the control group (27). The results of Davidsson et al. in the cancer group confirm the findings of our study on the high prevalence of P. acnes in cancerous specimens. In other words, in both studies, the prevalence of P. acnes is lower in the control group than in the PCa group. The only difference between the results of these two studies is the difference in the prevalence of P. acnes in the control group, which is 58% in the present study in comparison with 26% in the Davidsson and colleagues study. The reason for this difference may be the use of benign samples instead of healthy samples, as the control group, in the present study. Although these specimens are not cancerous, they may have some degrees of malignancy that may affect the outcome of this study. That is why the prevalence of bacterial acne protein in the control samples of this study was higher than that of Davidsson et al. study. In addition, Davidsson et al. studied patients and healthy people in the age range of 42 to 81 years-old while in our study, the age range in both groups was 50 to 89 years. Regarding the fact that the study patients and control group were older in this study, it can justify the high prevalence of P. acnes in the control group of this study compared to the study by Davidsson et al.
Due to the global prevalence of genitourinary infections and anatomic location of the prostate, this matter that infectious agents may play a role as a risk factor in PCa it is not surprising. The results of this study support the hypothesis of a relationship between P. acnes infections and PCa and it can be concluded that the inflammatory effects caused by this organism, together with other risk factors, can be effective in PCa. Therefore, the early diagnosis and early treatment of P. acnes infections can be used as a common method of prevention and treatment of PCa.
The authors would like to thank the cancer research center of Shahid Beheshti University of Medical Sciences, Tehran, Iran, for their sincere assistance and efforts to make this project happen.
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text:
TuksTriathlon
When & Where do I train
#TuksTriathlon: Triathletes can win SA's first medal at the Commonwealth Games
Tomorrow morning by the time most people go to work South Africa's triathletes might have won the first medal at the Commonwealth Games at Australia's Gold Coast
Richard Murray and Henri Schoeman are respectively ranked 2nd and 3rd for the 750m swim, 20km cycle and 5km run event and with just reason. Murray has already won two World Cup-races (Cape Town and Mooloolaba) this year while Schoeman outrode everybody on the cycle leg to win the Abu Dhabi World Series race.
Lindsey Parry who is the national triathlon coach said after watching Murray and Schoeman train this week, he could see that both of them are in good form. According to him, they are also highly motivated.
"There is definitely a medal on the cards for South Africa. It is going to boil down to as who wants it the most and can keep his cool. There is a real chance that both can medal, but then they really will need to be on top of their game especially since both England's Brownlee brothers (Alistair and Jonny) are racing. They are formidable triathletes. Alistair has won the gold medal at the 2012 and 2016 Olympic Games while Jonny won bronze and silver," said Parry.
Alistair Brownlee is the defending Commonwealth Games champion.
The Tuks/HPC based coach predicts that at least nine of the athletes who will be competing have a realist chance to medal. He considers Wian Sullwald (Tuks/HPC) as the one who can cause a major upset.
At last year's World Series race in the Gold Coast Sullwald finished ninth while Schoeman was eight. The Commonwealth triathlon course is the same.
Simone Ackermann and Gillian Sanders are South Africa's two female triathletes who will be competing.
Although it is highly unlikely Parry is of the opinion that it would be a mistake to discount their chances to medal entirely.
"Simone proved she is quite good when there is a breakaway situation during a race. During the Cape Town World Cup, she showed that she has gotten a lot stronger on the run and that is good.
"If the women's race can stay together Gillian could surprise as she is solid on the run. Unfortunately, her swim has let her down in the past. Then again one of her best performances last year was at the Gold Coast when she finished ninth."
The women's race will tomorrow be broadcasted live from 01:30 on DStv Channel 213 and the men's race from 05:00.
- Author Wilhelm de Swardt
Published by Leonore Jordaan
Lindsey Parry, coach. Photo Credit: Reg Caldecott


About a year ago, I posted a brief item in my blog The A&P Student about academic honesty. It succinctly describes what "academic integrity" is and explains clearly why it's in a student's own best interest to cultivate and practice academic integrity.
Research shows that people who practice dishonesty become more dishonest over time. Yikes. Apparently, it's so easy to get in the habit of cheating that it soon becomes part of who you are and what you always do! Don't let that happen to you . . . it will only cause misery.
This is an especially important lesson for those going into either the health professions or medical research.
After reading in What the Best College Teachers Do that professors recognized as "master teachers" have all abandoned fretting over futile attempts at building elaborate layers of defense against cheating for a more effective strategy: developing a culture of integrity in the course. The old "honor system" really does work in a context of reasonable precautions!
In my dream, I wake from unconsciousness as I'm being wheeled into an emergency room, strapped to a gurney. A health professional (for me it's a nurse) is covering my face with a mask as she (sometimes it's a he) says, "hey Dr. Patton, remember me? I was the one you flunked in A&P for cheating. I'm here to take care of you now." I try to break free, but the straps hold tight. I try to shout out, but the mask prevents it. I wake up in a cold sweat.
I explain that this could be any of us. Or our family or friends. And ask them all to join me in creating a culture of integrity in our course.
Consider putting a link to Why be honest? in your course material. Perhaps even make it required reading. For example, my friend Gary Heisermann includes a link and related question about the content in his first homework assignment, which reviews and emphasizes various important policies in his A&P course. I include it in each course syllabus.
I always start my A&P 2 with a final exam. WHAT?! Yep, that's right. I start with a FINAL exam!
It's a version of the final exam that I give my A&P 1 students. I warn them in A&P 1 that they need to retain all these concepts . . . they'll surely see them again. Then when they return from their break to start A&P 2, WHAM! Right in the face.
I call this exam that starts off my A&P 2 course "Test Zero." It's before the first regular test of A&P 2, Test One, so that makes sense. But it does "count" toward their course grade. It's a randomized, online test that they can do up to three times (each attempt is a different version of the exam).
Test Zero reviews the entire A&P 1 course--including the hard parts. It helps them brush up on what I want them to know to be successful in their A&P 2 course. And later courses.
It's also another opportunity for them to practice. As we all know, if we don't use it, we'll lose it.
I've done this for many years now and it works wonderfully. I can really see a difference each time we encounter an "old" idea from A&P 1.


Bring the kids along to Agonda Beach and Palolem Beach. There's still lots to do: enjoy the sand and surf at Baga Beach, admire the striking features of Se Cathedral, take in the spiritual surroundings of Shanta Durga Temple, and look for all kinds of wild species at Animal Shelter Agonda.
For maps, reviews, ratings, and other tourist information, use the Goa online trip itinerary planner .
In May, daytime highs in Goa are 36°C, while nighttime lows are 32°C. Finish your sightseeing early on the 12th (Sun) so you can travel back home.


See below for information on how to check the balance on your Bass Pro Shops Gift Card. You can check your card balance by calling the number below, or online using the link provided, or in person at any Bass Pro Shops store location.
All questions regarding your gift card balance should be directed at Bass Pro Shops.


text:
Consumer DiscretionaryMSOANGISODAOUTRGRTSF
Five Household Names that Wall Street Hates
Jacob Harper Follow
| Thursday, 17 October 2013 19:42 (EST)
Short-selling, or betting that a stock will go down, does not get quite as much attention as long investing, but it certainly has its vocal proponents. The famous trader/short-seller Jim Chanos, for instance, made a fortune shorting energy giant/pyramid scheme Enron, and was one of the first people to point out that the company's accounting practices seemed fishy. When done like Chanos does, short-selling, can actually be a force of good, a byproduct of diligent investor research that can expose the underlying instability of a doomed company.
While short-sellers aren't always right, it can be interesting to see which stocks Wall Streeters have started shorting en masse. So we went looking for which companies on market had the highest float short, with an emphasis on "household name" stocks that neophyte investors tend to be attracted to.
These are the five commonly known stocks most hated by investors as of Oct. 17:
Outerwall Inc. (previously Coinstar) ($OUTR)
Current Share Price: $64.72
Float Short: 34.68 percent
Why Wall Street Might Hate Them: Outerwall began as Coinstar, which put change kiosks into supermarkets, turning change into cash for an approximate 9 percent cut. But Outerwall isn't just in the money-changing business: they're in the kiosk business, with their most popular installation being video-rental delivery system RedBox. While still moderately popular, RedBox is getting absolutely crushed by Netflix Inc. ($NFLX), which many analysts have pegged as being the future of video rental.
Why Wall Street Might Be Wrong: Outerwall is actively diversifying, looking to move into coffee-dispensing kiosks and other food and beverage stands that capitalize on a lack of labor costs. If successful, the company can move past RedBox and prove the shorters wrong.
RadioShack Corp. ($RSH)
Current Share Price: $3.35
Why Wall Street Might Hate Them: RadioShack has seemed like a moribund company for some time, a relic of a bygone age. Even back in 2007, the satirical newspaper The Onion published an article entitled Even CEO Can't Figure out How RadioShack Still in Business.
Why Wall Street Might Be Wrong: But six years later, they're still around, and while they have indeed dropped off precipitously as mainstream technology has advanced past them, they've found a bit of a second life as a specialty electronics retailer, and have continued to defy short-sellers.
Angie's List ($ANGI)
Float Short Percentage: 41.58 percent
Why Wall Street Might Hate Them: Angie's List recently spooked investors by announcing they were drastically cutting the price of their contractor-review site, leading to speculation they weren't bringing in the customers at nearly a fast enough clip. Coupled with the facts that Angie's List is bleeding market share to Yelp Inc. ($YELP) and does not look to grow anytime soon, Angie's List's prospects look incredibly dire.
Why Wall Street Might Be Wrong: The heavy short action against Angie's List has been spurred by this speculation, but for the time being it's just that. In their defense, Angie's List said the price slash was an experiment for specific markets. Until Angie's List reports on Oct. 23, no investor can be quite sure the company is losing membership as fast as suspected, or is indeed just trying something new.
SodaStream International Ltd. ($SODA)
Why Wall Street Might Hate Them: SodaSteam is based almost exclusively around one product: the eponymous SodaStream home carbonator. There's no question this Israel-based company has found enormous success with their one product, especially in Nordic countries. But the extreme lack of diversification means the company is incredibly vulnerable, and is always one competitor's invention away from going kaput.
Why Wall Street Might Be Wrong: Short sellers previously loved Green Mountain Coffee Roasters, another company largely based on one product: single serving "K-cups" of coffee. While the company did indeed drop last year, they have rebounded throughout 2013, proving that sometimes one good product is all you need.
Martha Stewart Living Omnimedia ($MSO)
Why Wall Street Might Hate Them: Martha Stewart's reputation has taken quite a hit since she went to the pokey for insider trading. While her media empire is still formidable, she is nowhere near the ubiquitous media force she once was, not to mention magazines in general are in decline. The confluence of dying magazine industry and the sullied reputation of its namesakes has made this company one of the most shorted on the entire market.
Why Wall Street Might Be Wrong: Martha Stewart is like the cockroach: a being that resfuses to die no matter the circumstances. If one person can make something positive out of a dire situation, look to America's Mom.
Follow	 OUTR Outerwall Inc. 52.00 0.00 0.00 0 Trade
Follow	 MSO Martha Stewart Living Omnimedia Inc. 6.25 0.00 0.00 0 Trade
Follow	 ANGI ANGI Homeservices Inc. 11.98 -0.21 -1.72 1,940,453 Trade
Follow	 GRTSF Athena Investments A/S 0.93 0.00 0.00 0
Follow Outerwall Inc.
Follow Martha Stewart Living Omnimedia Inc.
Follow ANGI Homeservices Inc.
Follow Athena Investments A/S


text:
The Little Ghost Who Was a Quilt
When you're a quilt instead of a sheet, being a ghost is hard! An adorable picture book for fans of Stumpkin and How to Make Friends with a Ghost.
Ghosts are supposed to be sheets, light as air and able to whirl and twirl and float and soar. But the little ghost who is a quilt can't whirl or twirl at all, and when he flies, he gets very hot.
He doesn't know why he's a quilt. His parents are both sheets, and so are all of his... Read More
He doesn't know why he's a quilt. His parents are both sheets, and so are all of his friends. (His great-grandmother was a lace curtain, but that doesn't really help cheer him up.) He feels sad and left out when his friends are zooming around and he can't keep up.
But one Halloween, everything changes. The little ghost who was a quilt has an experience that no other ghost could have, an experience that only happens because he's a quilt . . . and he realizes that it's OK to be different.
When you're a quilt instead of a sheet, being a ghost is hard! An adorable picture book for fans of Stumpkin and How to Make Friends with a Ghost.

Ghosts are supposed to be sheets, light as air and able to whirl and twirl and float and soar. But the little ghost who is a quilt can't whirl or twirl at all, and when he flies, he gets very hot.

He doesn't know why he's a quilt. His parents are both sheets, and so are all of his friends. (His great-grandmother was a lace curtain, but that doesn't really help cheer him up.) He feels sad and left out when his friends are zooming around and he can't keep up.

But one Halloween, everything changes. The little ghost who was a quilt has an experience that no other ghost could have, an experience that only happens because he's a quilt . . . and he realizes that it's OK to be different.
0.0010249999999999999 kg
11.3800 × 8.6300 × 0.4300 in
An Old Man's Winter Night
Screech!
Footsteps in Bay de Verde


text:
Q: Contents not showing on CPropertyPageEx I have created a program which uses Property Sheet Ex as the main program which holds several pages that user Property Page Ex. When i run the program, the first page shows fine, pages has only List Control on it and i have 2 pages, but when i click the tab to the next page, it is not showing anything and also when i click the first tab, i don't see the List Control.
IMPLEMENT_DYNCREATE(CPageExposure, CPropertyPageEx)

CPageExposure::CPageExposure() : CPropertyPageEx(CPageExposure::IDD){}

CPageExposure::~CPageExposure()
{
}

void CPageExposure::DoDataExchange(CDataExchange* pDX)
{
 CPropertyPageEx::DoDataExchange(pDX);
 DDX_Control(pDX,IDC_LIST2,m_list);
}

 BEGIN_MESSAGE_MAP(CPageExposure, CPropertyPageEx)
 ON_WM_SIZE()
 ON_WM_DESTROY()
 END_MESSAGE_MAP()

 BOOL CPageExposure::OnInitDialog()
 {
 CPropertyPageEx::OnInitDialog();

 CRect rc; int cx;
 GetClientRect(&rc);

 cx = (rc.Width()-30)/3;

 m_image.Create(1,20,ILC_COLOR,0,1);
 m_list.SetImageList(&m_image,LVSIL_SMALL);

 m_list.InsertColumn(0,"Time",LVCFMT_LEFT,cx);
 m_list.InsertColumn(1,"Login",LVCFMT_LEFT,cx);
 m_list.InsertColumn(2,"Request",LVCFMT_LEFT,cx);
 m_list.SetExtendedStyle(LVS_EX_FULLROWSELECT | LVS_EX_GRIDLINES);

 return(TRUE);
 }

I hope you can help me with this..
Thanks...

redpajama_set_name: RedPajamaStackExchange


text:
Retail's Big Mistake: Slashing Payroll Cuts into Profits
Subscribe on iTunes!
mic Listen to the podcast:
Wharton's Marshall Fisher, Santiago Gallino and Serguei Netessine discuss their research on the impact of staffing on retailers' profits.
http://media.blubrry.com/kw/p/d1c25a6gwz7q5e.cloudfront.net/audio/20190110C-KWR-Fisher-Gallino-Netessine.mp3
When sales are down and the quarterly report is due, a common strategy for retailers to boost profits is to cut labor. Payroll is the second-largest expense for most stores, so reducing associates' hours is a fast, easy way to make the numbers work. But this quick fix is "business school thinking gone wrong," according to Wharton professors of operations, information and decisions Marshall Fisher, Serguei Netessine and Santiago Gallino. It is imperative for retail companies to recognize that employees are the most valuable asset on any sales floor, especially now. Increased competition from online shopping threatens the very existence of many physical stores, so top-shelf service can make the difference between a customer making a purchase or walking out in frustration.
In their latest research, the professors make the case for having an adequate, well-trained staff as the long-term solution to stable profit margins. They also unveil a mathematical approach they have devised to help companies determine how much staffing is needed at which locations. The research is captured in a paper titled, "Setting Retail Staffing Levels: A Methodology Validated with Implementation."
"Understaffing stores and undertraining workers was never a good idea, but it's especially bad now, because it takes away the biggest advantage traditional stores have over e-tailers: a live person a customer can talk with face-to-face," the professors wrote in an article for Harvard Business Review. They joined the Knowledge@Wharton radio show on Sirius XM (listen to the podcast above) to talk about their work and share the embedded lesson for retailers who don't want to become the next statistic. Nearly 8,000 stores closed in 2017, according to investment banking firm UBS.
To be fair, the professors said, retail is a tough business with extremely high turnover. For many managers, underinvesting in training for employees who could be gone in six months anyway seems like a sound decision.
"It's easy to criticize when you're not in their shoes, and it's totally understandable," Fisher said. "At the end of the day, you've got an earnings report if you're publicly traded, and you've got to think about that."
"Cutting cost is OK if you're cutting fat, but if you're cutting muscle, that does more harm than good." –Marshall Fisher
But temporary reductions in personnel or hours often become permanent or cyclical, and stores get caught in what the professors describe as a downward spiral until there is little or nothing left. "Cutting cost is OK if you're cutting fat, but if you're cutting muscle, that does more harm than good. And we see this in the data that we analyze," Fisher said.
Using statistical software tools, the professors created the following three-step methodology for retailers to set staffing levels at each store location:
Use historical data on revenue and planned and actual staffing levels by store to estimate how revenue varies with the staffing level at each store. Use employee absenteeism to help you: If an employee does not show up for work at the last minute, check sales impact.
Using historical analysis as a guide, validate the results by changing the staffing levels in a few test stores.
Implement the results chain-wide and measure the impact.
The professors employed this method with several retailers, including a large specialty retailer, with significant results. For one retailer, right-sizing the staff in 168 stores over a six-month period produced a 4.5% revenue increase and a nearly $7.4 million annual profit increase, after accounting for the cost of the additional labor.
"I hope that our methodology can help retailers start thinking about sales impact of labor," Netessine said. "All retailers think about, for example, sales impact of marketing activities. Should we put more marketing into Facebook or newspapers or TV? But very, very few retailers systematically think about what is the value-added of an extra dollar of labor in a particular store. In some stores, it's negative. And in some stores, it's a huge positive effect. Our experience in working with probably dozens of retailers at this point is that, over the years, they've been cutting, cutting, cutting, so there is usually a big impact of adding labor to the store.
Teach Them Well
The key to retail success isn't just setting the right staffing numbers. The professors advocate for employees to be trained properly in both the products and the processes of the store.
"One surprising thing we found is that when you train store employees on a particular product, it's not that they increase sales of only that product. What we found is they actually increase sales across a product category," Netessine said. "We surveyed tens of thousands of employees, trying to understand what it is exactly that they learned. And what we found is that the training gives them overall confidence about the entire line of products."
"The way to think about [employees] is as partners in the success that the company can have going forward." –Santiago Gallino
Fisher shared a personal story to illustrate how a well-educated salesperson is an asset on the floor: He enjoys backpacking with his son, so he went to a local store in suburban Philadelphia called Out There Outfitters to buy a rain jacket. The store uses a service called ExpertVoice (formerly Experticity) to train associates on the various products, so the salesperson easily explained the features and materials of each rain jacket in stock.
"I walked out having made a purchase," he said. "That's the value of training. You have a broad assortment. You explain it to the customer, and they know they don't have to go somewhere else because they've picked the best choice for them."
Some retailers are reluctant to spend what they may consider lost time on training when they could have an employee on the floor. But that's a mistake, the professors say. Their research found that for every hour a month an employee spent on simple online training, the revenue from that employee went up about 6% that month. This training doesn't have to be a formal, disruptive affair. ExpertVoice offers online modules that employees can complete on their smartphones during downtime, for example.
"I would like to think that our research can help emphasize the fact that employees are a huge asset for the retailer, that the way to think about them is as partners in the success that the company can have going forward," Gallino said. "Being able to train them, retain them, assign them to the right times of the day or the right store throughout the chain is key to the success of the company and also for the employees to have a rewarding job."
Digital exerts even greater pressure on brick-and-mortar locations to offer shoppers a reason to put down their devices, get off the couch and drive to the store. That's where great sales associates can help, Gallino noted.
"I hope that our methodology can help retailers start thinking about sales impact of labor." –Serguei Netessine
"What I've been hearing from retailers is that they see that their physical presence needs to become more experiential," he said. "If you want to give customers a good experience when they go to the store, then this goes beyond knowledge about facts of the product. It's being engaged, greeting the customer, learning how to interact with him or her."
Added Netessine: "We looked at what people care about once they come to a physical store, and inevitably how knowledgeable employees are comes out as No. 1."
The bottom line is that employees are an essential part of any retail operation's top line, the professors said. It's time for CEOs to manage beyond the numbers and see employees as something more than an expense.
"Retailers are struggling to maintain the top line, and we're talking about things that can add 5% in the staffing, 6% for an hour of training," Fisher said. "So, I think the key points are this is a gold mine opportunity for retailers."
"Retail's Big Mistake: Slashing Payroll Cuts into Profits." Knowledge@Wharton. The Wharton School, University of Pennsylvania, 14 February, 2019. Web. 17 January, 2021	<https://knowledge.wharton.upenn.edu/article/retail-staffing-model/>
Retail's Big Mistake: Slashing Payroll Cuts into Profits. Knowledge@Wharton (2019, February 14). Retrieved from https://knowledge.wharton.upenn.edu/article/retail-staffing-model/
"Retail's Big Mistake: Slashing Payroll Cuts into Profits" Knowledge@Wharton, February 14, 2019,
accessed January 17, 2021. https://knowledge.wharton.upenn.edu/article/retail-staffing-model/
Why You Shouldn't Be Afraid to Ask Sensitive Questions
New research co-authored by Wharton's Maurice Schweitzer reveals that most people don't really mind answering sensitive questions, and asking them doesn't leave a bad impression.
Colour Life: Using Technology to Reinvent Real Estate Management
Founded in 2002, Colour Life has grown to become one of the world's largest residential property managers, managing over 420 million square meters across more than 3,000 communities in mainland China, Hong Kong, and Singapore. While Colour Life's growth in[…]


Our Refresh Hoody is one of the latest additions to our women's hoody range. The fashion fit zipped hoody features a cute patterned flower design in Pink and White to the body and arms.. The Refresh hoody features extended cuffs with thumb holes for additional comfort and 2 exterior pockets.
Available in sizes S – XXL, the Refresh hoody features FRO Systems high density stickers to the chest, forearm and lower back.


text:
package cs201.gui;

import java.awt.Color;
import java.awt.Component;
import java.awt.Dimension;
import java.util.ArrayList;
import java.util.List;

import javax.swing.BorderFactory;
import javax.swing.Box;
import javax.swing.BoxLayout;
import javax.swing.JDialog;
import javax.swing.JLabel;
import javax.swing.JPanel;
import javax.swing.JSlider;
import javax.swing.event.ChangeEvent;
import javax.swing.event.ChangeListener;

import cs201.helper.CityDirectory;
import cs201.helper.Constants;

/**
 * The frame shown to manipulate time in SimCity201.
 * @author Ben Doherty
 *
 */
@SuppressWarnings("serial")
public class TimePanel extends JDialog implements ChangeListener {

	/* *********
	 * CONSTANTS
	 * *********
	 */

	private static final int BORDER_THICKNESS 	= 20;
	private static final int FRAME_HEIGHT 		= 200;
	private static final int FRAME_WIDTH 		= 500;
	private static final int SLIDER_MIN			= 200;
	private static final int SLIDER_MAX			= 5000;
	private static final int SLIDER_INIT		= 2000;
	private static final int MAJOR_TICK 		= 500;
	private static final int MINOR_TICK 		= 100;

	/* ***********
	 * COMPONENETS
	 * ***********
	 */

	JPanel panel = new JPanel();
	JSlider slider = new JSlider(JSlider.HORIZONTAL, SLIDER_MIN, SLIDER_MAX, SLIDER_INIT);
	JLabel timeLabel = new JLabel("2.00 seconds of real time = 15 minutes in SimCity201");

	/* ***********
	 * CONNECTIONS
	 * ***********
	 */

	/* *********
	 * VARIABLES
	 * *********
	 */

	List<StructurePanel> structurePanels = new ArrayList<StructurePanel>();

	/* ************
	 * CONSTRUCTORS
	 * ************
	 */

	public TimePanel() {
		// Frame set up
		setBackground(Color.LIGHT_GRAY);
		setMinimumSize(new Dimension(FRAME_WIDTH, FRAME_HEIGHT));
		setMaximumSize(new Dimension(FRAME_WIDTH, FRAME_HEIGHT));
		setPreferredSize(new Dimension(FRAME_WIDTH, FRAME_HEIGHT));
		this.getContentPane().add(panel);
		panel.setBorder(BorderFactory.createEmptyBorder(BORDER_THICKNESS, BORDER_THICKNESS, BORDER_THICKNESS, BORDER_THICKNESS));
		panel.setLayout(new BoxLayout(panel, BoxLayout.Y_AXIS));

		setUpComponents();
	}

	/* ****************
	 * PUBLIC FUNCTIONS
	 * ****************
	 */

	/**
	 * Shows the time panel.
	 */
	public void showTimePanel() {
		this.setVisible(true);
	}

	/**
	 * Called to reset this panel when starting a new scenario/resetting the city
	 */
	public void resetCity() {
		this.slider.setValue(SLIDER_INIT);
		this.setTimeLabel(SLIDER_INIT);
	}

	/**
	 * Adds a structure panel to the list of structure panels that will be affected by time shifts.
	 * @param panel
	 */
	public void addAnimationPanel(StructurePanel panel) {
		structurePanels.add(panel);
	}

	/* *****************
	 * PRIVATE FUNCTIONS
	 * *****************
	 */

	private void setUpComponents() {
		// Add a slider
		slider.addChangeListener(this);
		slider.setMajorTickSpacing(MAJOR_TICK);
		slider.setMinorTickSpacing(MINOR_TICK);
		slider.setPaintTicks(true);
		slider.setPaintLabels(true);
		slider.setAlignmentX(Component.CENTER_ALIGNMENT);
		panel.add(slider);

		// Add some space
		panel.add(Box.createRigidArea(new Dimension(0, 20)));

		// Add a label
		timeLabel.setAlignmentX(Component.CENTER_ALIGNMENT);
		panel.add(timeLabel);
	}

	private void setTimeLabel(int value) {
		double realSeconds = value / 1000.0;		// convert from milliseconds to seconds
		String text = String.format("%.2f seconds of real time = 15 minutes in SimCity201", realSeconds);
		timeLabel.setText(text);
	}

	private void updateTime(double speedFactor) {
		for (StructurePanel thisPanel : structurePanels) {
			thisPanel.setTimerOut(speedFactor);
		}
		CityPanel.INSTANCE.setTimerOut(speedFactor);
		Constants.ANIMATION_SPEED_FACTOR = speedFactor;
	}

	/* *****************
	 * SETTERS / GETTERS
	 * *****************
	 */

	/* *********
	 * CALLBACKS
	 * *********
	 */

	@Override
	public void stateChanged(ChangeEvent e) {
		JSlider source = (JSlider)e.getSource();

		// Update the label
		setTimeLabel(source.getValue());

		// Get the new value
		int timeValue = source.getValue();

		// Update the overall city time
		CityDirectory.getInstance().setTimerOut(timeValue);

		// Update each individual structure panel
		updateTime(timeValue / 2000.0);
	}

}

redpajama_set_name: RedPajamaGithub


text:
The clue's in the name. Great Britain packs so much greatness into its pint-sized shores: crumbling castles, soaring cathedrals, quaint villages, timeless landscapes and history galore.
Centuries of History
Visiting Britain is like travelling in your own personal time machine. More than 5000 years of history are sown into the British soil: here you can walk around a neolithic stone circle, stand atop an Iron Age hill fort, visit a Roman bath, conquer a Norman castle, marvel at a medieval cathedral, wander around a Victorian museum and admire the view from a 21st-century skyscraper. History is everywhere – and if you want to understand what makes Britain tick, you have to gaze into its past.
British Eccentricity
It won't take long travelling round Britain to realise that it's just a little bit, well, eccentric. Since time immemorial, this has been a country determined to do things its own way: in art, architecture, literature, engineering, music, politics and comedy, the British just never seem happy to follow the herd. Perhaps it's because Britain is an island nation; no doubt it has something to do with the infamously unpredictable weather. Whatever the case, any country that can dream up welly-wanging, cheese-rolling, maypole dancing, tar-barrel racing and caber tossing simply has to be worth a visit.
It's just 874 miles from top to bottom, but Britain boasts an astonishing diversity of landscapes: moors, mountains, glens, lakes, woodlands, fields, dales and endless miles of craggy coastline. Throw in 15 national parks, numerous nature reserves and countless beauty spots, and it all adds up to a nonstop inspirational panorama – as generations of poets, painters, musicians and photographers have discovered to their, and our, advantage. Tramp the hills, cycle the lanes, bask on the beaches and wander the cliffs – the great British countryside awaits.
When it comes to culture, Britain is a world-beater. London is home to the nation's leading institutions, including big hitters such as the British Museum, the V&A, the Tate Modern and the Natural History Museum. But world-class museums and galleries are scattered across the island: there's Glasgow's wonderful Kelvingrove Art Gallery, Newcastle's BALTIC arts centre, Edinburgh's National Museum of Scotland and outposts of the Tate in Liverpool and St Ives. But often it's the weirdest ones that are the most fun: look around and you'll discover museums devoted to Bakelite, lawnmowers, waxworks, witchcraft and even the humble pencil. Only in Britain.
Explore Great Britain
More in Great Britain
The world's largest and oldest continuously occupied fortress, Windsor Castle is a majestic vision of battlements and towers. Used for state occasions, it…
A splendid mixture of architectural styles, Westminster Abbey is considered the finest example of Early English Gothic. It's not merely a beautiful place…
Edinburgh Castle has played a pivotal role in Scottish history, both as a royal residence – King Malcolm Canmore (r 1058–93) and Queen Margaret first made…
One of London's most amazing attractions, Tate Modern is an outstanding modern- and contemporary-art gallery housed in the creatively revamped Bankside…
Welcome to one of Northern Europe's most significant Roman sites. Today more than a million visitors a year come to see its historic finds, atmospheric…
Canterbury Cathedral
A rich repository of more than 1400 years of Christian history, Canterbury Cathedral is the Church of England's mother ship, and a truly extraordinary…
With its thunderous, animatronic dinosaur, riveting displays about planet earth, outstanding Darwin Centre and architecture straight from a Gothic fairy…
Sir Christopher Wren's 300-year-old architectural masterpiece is a London icon. Towering over diminutive Ludgate Hill in a superb position that's been a…
Few parts of the UK are as steeped in history or as impregnated with legend and superstition as the titanic stonework of the Tower of London. Not only is…
Show all attractionsMore in Great Britain
Latest Stories from Great Britain
The best British campsites for summer 2022: picture-perfect coasts, glamping and more
Britain has thousands of campsites to choose from for families this summer. Here are the best to explore in 2022.
How hiking Britain's longest trail helped me recover from COVID-19
After a severe case of COVID-19, writer Richard Collett looked to a hiking route famous for its power to heal.
The 3 greatest road trips in Britain: hop in you car or jump on your bike
Feb 9, 2022 • 7 min read
Hit the road with these three great driving routes, each providing a snapshot of the history, culture, and landscape of England, Wales, and Scotland.
The best one-day hikes in Great Britain
Call it a hike, a stroll, a toddle or a ramble – there's nothing the British like better than a walk in the countryside. Here are the island's best one-day…
The Beatles in Liverpool: A Fab Four fan's guide
The Beatles were four young lads from Liverpool who revolutionized pop music. Here's how fans can explore their roots on a visit to the city.
The Caledonian Sleeper: Britain's best train journey?
From choosing cabins to buying tickets, here's what you need to know about the Caledonian Sleeper, one of Britain's best night train services.
Why do they celebrate Bonfire Night in the UK?
Find out why the Brits mark November 5 - or Bonfire Night - with fireworks, and plan ahead to see the best displays and events in England in 2021.
6 new walking trails in northeast England trace the region's unique history
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Review & Excerpt: Vanishing Hour by Laura Griffin
Publisher: Berkley
Source: the publisher in exchange for an honest review
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When a cold case in Texas leads to a sinister string of disappearances, a newcomer to the small town helps the deputy sheriff to piece together the clues in this new romantic thriller from New York Times bestselling author Laura Griffin.
Corporate lawyer Ava Burch has had enough of the big city and daily grind. She grew up with her father, who raised search-and-rescue dogs, in rural Texas, and has moved to the small town of Cuervo to spend time in the dry, rugged wilderness near Big Bend National Park. When she and her dog Huck discover an abandoned campsite on a volunteer search-and-rescue mission, she's perplexed but she carefully photographs it all the same.
All Deputy Sheriff Grant Wycoff can see when he looks at Ava is a city slicker—with her designer jeans and expensive car— who has no business on a serious team made of seasoned outdoorsmen and retired cops. But when she tells him of her discovery on the trail, he sees there's more to her than meets the eye.
Ava's discovery reminds Grant of the unsolved case of a young woman who went missing two years ago. As they look into the campsite further, another woman disappears under odd circumstances. With time running out, Ava and Grant must work against the brutal heat from both the Texas sun and their own electric chemistry to solve the case.
Oh, I've been enjoying Laura Griffin's books for several years now. The first time I read this book, I enjoyed it so much I went on a reading binge of her Tracers series, thanks to my local library system. Then I read this one again; it's not a part of the Tracers series by the way. I just had an urge to reread them.
"Vanishing Hour"is a stand alone, though Griffin did set up two other characters as a potential romantic couple. This book's couple, Ava and Grant, are two independent, hard-working, dedicated souls who find each other while looking for a missing person. Ava has trust issues, stemming from her late father, but that hasn't stopped her from turning her life upside down after his death. Grant lives to work, seemingly lacking any personal life. So of course, they turn to each other, lol. I did wonder at times if Grant was interested in Ava less as a person and more as someone, some thing, he couldn't have as she was initially reluctant. But Griffin showed me I was wrong, thankfully.
Both the romance and the mystery are strong, Griffin balanced them, and developed most of the the characters nicely. Grant didn't grow as much as Ava did but we got his POV and experienced his feelings. One thing I liked was that unlike in many romantic suspense stories, and cozy mysteries too, Grant as a police officer was careful in what information he shared with Ava. So often, the law enforcement officer in these books is too willing to share information with civilians. I appreciated that Grant stayed true to his ethics. Ava understood but was sometimes frustrated, understandably. She and Grant approached the mysteries from different angles and found different clues. Ava was a good researcher, as befits a lawyer, and she worked quite well with Huck, her inherited rescue dog. I liked Huck and thought Griffin made good use of him. He was an excellent search dog and also helped Ava, providing companionship, pure love, and good-natured antics.
"Vanishing Hour" was another solid, engaging and entertaining story, worthy of more rereads.
Missing children are an emergency. Always. Their little bodies are less able to regulate temperature, so they're especially vulnerable to exposure. And in a place as vast and rugged as Silver Canyon State Park, additional hazards abounded: rattlesnakes, coyotes, hundred-foot cliffs. Even the anemic little creek that Ava had been following was terrifying. A child Noah's size could drown in a bathtub.
Ava glanced up at the relentless sun that sucked moisture out of everything beneath it. She looked ahead at Huck, who trotted back and forth in front of her in his zigzag pattern. He was working the wind, as he'd been trained, tirelessly sniffing the air with his powerful nose, which could pick up anything with human scent on it, from a candy wrapper to a dropped article of clothing.
So far, nothing.
Ava checked her watch. Two long hours since she'd left the trailhead. Sweat stung her eyes, and she wiped her forehead with the back of her arm. She paused beside a boulder and dropped her pack on the dusty ground to retrieve one of her water bottles. Huck needed some, too, but right now he was intent on his work.
She took a lukewarm sip and scanned the scrub brush lining the canyon wall. Young children had a tendency to wander aimlessly until they found a place to curl up for a nap. Some would even hide from search teams, afraid of getting in trouble for being lost. So Ava had been incessantly scanning pockets of brush.
Huck halted in front of her, his nose lifted in the air. Ava froze and watched. But then his head dropped down and he resumed his zigzags. Ava tucked the water bottle away and pushed off the boulder to continue her trek.
She watched Huck, amazed by his energy. Even in this heat, he loved working, and when he had his vest on, he didn't have an off switch. As he bounded around in front of her, she thought of the other teams, especially the canine one. She was surprised they hadn't found something close to camp.
Of course, the parents had been there, which might have been a problem. Frantic parents threw off a lot of scent, which could have overpowered Noah's smell and possibly confused the dog.
Also, the temperature rising in the canyon could have wafted the scent up, well above the dog's nose. Yet another challenge here was that young children didn't throw off as much scent as adults. And still bodies-ones that were either asleep or unconscious-threw off less scent, too.
So there were all kinds of factors in play, especially in a park this size.
Ava checked her watch again and sped up her pace, unable to shake the feeling of dread that had been settling in her stomach as the hours ticked by. Scanning the canyon wall, her gaze caught on something beige and triangular.
A tent? No.
A tarp. She climbed onto a boulder for a closer look. About halfway up the slope of the canyon was a sand-colored canvas tarp that had been stretched taut to create a patch of shade. It looked like a primitive fort-just the sort of thing that would attract a kid's attention, and her pulse quickened as she climbed closer. Nearing the tarp, she spied a small yellow tent tucked in the shade beneath it.
She glanced around for Huck, but he was sniffing along at the base of a rockslide.
Grabbing hold of a juniper tree, Ava levered herself onto the ledge. She ducked under the tarp and paused a moment for her eyes to adjust. The little tent was unzipped. Hope ballooned in her chest as she pulled back the flap and poked her head inside.
Her hope disappeared as she scanned the interior. No sleeping child curled up in the dimness. The air was utterly still, and everything was coated with a thin layer of dust, as though no one had been there in weeks, maybe months. A pile of gear in the corner included a cookstove, a hiking boot, and a blue bedroll with a carabiner clipped to it. Attached to the carabiner was a black key fob.
A chill snaked down her spine. Who would leave their car key out here? The fob seemed odd. Ditto for the hiking boot. Where was the other one? And where was its owner?
On impulse, Ava took out her phone and snapped a couple of pictures. As part of her SAR training, she'd learned to document crime scenes. She couldn't pinpoint why, exactly, but that was what this felt like. She ducked
out and snapped a shot of the exterior. A faint bark pulled her attention back to the mission. She couldn't afford to get sidetracked, even though this place felt creepy. She put her phone away as she skimmed the surrounding area for the missing boot, or any sign of the boot's owner. She glanced up the canyon, looking for evidence of a fire pit or any other camping equipment.
A soft whimper had her turning around.
Huck sat beside a rock pile, his ears pricked forward and his gaze fixed on hers. Ava's heart skittered. This was his sit alert letting her know he'd found something.
"Show me," she commanded, and he sprang into action, bounding across the creek bed. She climbed down the rocks and jogged after him, frantically searching the clumps of trees. Huck darted around a giant prickly pear cactus and behind a line of mesquite trees. Amid the fluttering green leaves, she caught a flash of red.
"Please, please, please," she murmured.
Huck disappeared beneath the brush and barked. Ava spied a small white sneaker and a pudgy leg.
Huck danced in a circle, drunk on success and eager for his reward.
"Good boy, Huck! Good boy! Good boy!" She filled her voice with praise, even though her heart had lodged in her throat. The little body wasn't moving. Oh God.
About the Author ~
Laura Griffin is the New York Times and USA Today bestselling author of more than twenty-five books and novellas. She is a two-time RITA Award winner, as well as the recipient of the Daphne du Maurier Award.
Check out her website, https://lauragriffin.com/
Posted by Bea at 12:00 AM
Labels: 2022, blog tour, excerpt, Laura Griffin, mystery, review, romance
Northwoman October 28, 2022 at 8:54 PM
I really enjoyed this one. The dog was an added bonus.
Anne - Books of My Heart
Bea October 28, 2022 at 9:04 PM
He really was.
Katherine P October 30, 2022 at 10:14 PM
This one is on my TBR. It looks like such a good read.
PS - I saw your email! Blogger ditched the email subscription and I haven't been able to get my act together enough to find an email subscription service! Soon I hope!
Bea October 30, 2022 at 11:08 PM
Aaah, that explains it. Yours wasn't the only one that suddenly disappeared so I was confused about what happened. Thanks!
I hope you like Vanishing Hour. FYI, the dog doesn't get hurt.
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Nolasiban works by blocking the hormone oxytocin, which is known to induce uterine contractions. Nolasiban reduces uterine contractions and could improve uterine blood flow, both effects being favourable for the embryo to properly implant.
MedicalResearch.com: What are the main findings of the recent study?
Response: The most recently released data from October 3 is from the IMPLANT2 Phase 3 trial, and the data shows an increase in live births (also called "Take Home Baby") that result from the earlier pregnancy results, demonstrating a consistent benefit without any safety issues. A total of 778 subjects participated in the trial, and these women were randomized into groups to receive the placebo treatment or receive Nolasiban. Women treated with Nolasiban received a single 900 mg oral dose four hours prior to embryo transfer (ET), and transfers took place either on Day 3 or Day 5. The results were significant: pooled data shows that treatment with Nolasiban resulted in a live birth rate of 34.8% compared to the live birth rate of 27.7% among women treated with the placebo, this represents a relative improvement of 25%. The benefits of Nolasiban are particularly strong in patients who undergo ET 5 days post egg retrieval, with a relative improvement of 35% in live births.
In February 2018, ObsEva released the primary endpoint data from the IMPLANT2 trial of Nolasiban during IVF treatment that showed an increase in ongoing pregnancy 10 weeks post ET to 35.6% compared to 28.5% for women treated with placebo, which is very consistent with the latest live birth data.
Response: Nolasiban is a novel drug, and it would be the first drug in the class to be approved for improving IVF outcomes. Clinical results have shown efficacy, as well as no safety issues with using the drug, which is given as a one-time oral treatment 4 hours prior to ET, and is cleared from the body within two days. A large portion of the global population takes advantage of IVF procedures as a result of infertility. Currently, there are 2 million cycles of IVF completed annually, and we feel this is in need of improved success rates given the high monetary and emotional costs for would-be parents.
MedicalResearch.com: What is the next step in research and development?
Response: We are planning additional clinical trials to begin by the end of 2018 that will supplement existing data and support future approvals. Given that trials to date have been conducted in Europe, our plan is to submit an application for approval to European regulators by the end of 2019, which could then be approved as soon as one year later. In the U.S., we are presently finalizing regulatory requirements with the FDA, so the timeline may be approximately one year behind that of Europe.
Response: At ObsEva, we are singularly focused on developing and commercializing novel therapeutics for serious conditions that affect a women's reproductive health and pregnancy. With Nolasiban, we believe that these data represent a major advancement and we are eager to work with regulators to make this treatment available to women as soon as possible. Nolasiban has the potential to increase pregnancy rates while limiting the likelihood of multiple pregnancies by improving rates even when a single ET method is employed.
This entry was posted in Author Interviews, Endocrinology, Fertility, OBGYNE and tagged IVF, medical research, ObGyne, ObsEva, Women's Health by Marie Benz MD FAAD. Bookmark the permalink.


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Spartans click on "Hall of Fame" to visit our recently updated SGHS Athletic Hall of Fame with all 90 members!
The 2017 Hall of Fame Weekend will be September 22-23... beginning with a halftime introduction of our newest honorees at the Friday night football game vs Oak Hills and then concluding with our annual Saturday golf tournament and banquet... this year at Morongo Golf Club, Tukwet Canyon in Cherry Valley!
SGHS Athletic Hall of Fame - Candidate Questionnaire
Each spring the SGHS Athletic Hall of Fame Committee reviews potential candidates to be inducted at the Hall of Fame Weekend activities the following fall.
We encourage anyone to fill out the Candidate Questionnaire who feels they may be deserving of this honor based upon their athletic accomplishments at San Gorgonio HS and post high school.
CLICK HERE for the Candidate Questionnaire and please submit it to Matt Maeda, SGHS Athletic Director at matthew.maeda@sbcusd.com or mail to 2299 E. Pacific St., San Bernardino, CA 92404.
Ryan Hunter-Simms Has Great Frosh Season at Oregon
Hunter-Simms had strong frosh season
SPORTS NOTES
By Obrey Brown, Sports Editor
Highland Community News
Published: Thursday, July 25, 2013 8:05 PM PDT
University of Oregon freshman Ryan Hunter-Simms, a San Gorgonio High School product, matched his personal best in the shot put with a throw of 53-5 3/4 (16.30m) to finish second at an April meet dual pitting No. 2 Arkansas against fourth-ranked Oregon.
Hunter-Simms' Oregon squad lost when the 4 x 400 went to the Razorbacks' relay, 86-77. A Ducks' win would've left Oregon with an 82-81 triumph.
The season's highlight may well have been Oregon's home meet win over No. 1-ranked Texas A&M at the Pepsi Invitational on April 6 – 194 1/2 - 180 1/2.
Hunter-Simms was second (50-8 1/4) to Washington State's Matt Wardell (51-10) in the shot put, outdueling Texas A&M's Dalton Rowan (46-11 3/4).
Rowan won the discus with Hunter-Simms (162-feet) coming up 26 1/2-feet short in fifth place.
Hunter-Simms, a two-way football player at San G, was the area's 2012 Ken Hubbs Award winner. He chose collegiate track & field over football and accepted an athletic scholarship to Oregon.
The San G product aligned himself with one of America's top track & field programs.
In June, Mac Fleet flew to victory in the men's 1,500 meters as the Oregon men's and women's track team took home a pair of trophies at the NCAA Track and Field Championships.
The women finished third with 43 points for their unprecedented fifth straight top three finish, while the men earned a trophy for the first time in four years, taking fourth with 44 points.
"It was a big push by the men today," said Oregon head coach Robert Johnson. "It was a big finish and for them to do that was huge.
"(The women) tried their hardest today and I couldn't be more proud of them."
Florida and Texas A&M tied for the men's title with 53 points. Arkansas was third with 46.5, followed by the Ducks.
Kansas won its first ever NCAA women's title with 60 points, followed by Texas A&M with 44 and Oregon.
Oregon hosted the NCAA, placed just one athlete in the weight event athlete (hammer thrower Greg Skipper) in the championships.
Texas sophomore Ryan Crouser, the top seed in the shot put, won the event by 1 1/2-inches (66-7 3/4, 20.31 meters) over Arizona State's Jordan Clark. Hunter-Simms' 16.3 meters was short of the NCAA qualifying mark. Oregon failed to land any qualifiers at the NCAA West Region at the University of Texas, held in May.
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Relatively small yet very comprehensive numismatic collection that is very locally relevant but also features objects from around the world. The bulk of the collection is comprised of Roman coins and commemorative medals but also includes coins, tokens and other objects from a diverse range of places and periods.
Specific strengths: Roman coins, locally relevant commemorative and military medals.
Is there a study facility? A meeting room can be booked upon request.
Is equipment (balances, magnifying glasses, etc.) provided? Magnifiers can be supplied.
Does the museum offer a service for identifying objects and other public enquiries? Yes but we don't tend to extend this to cover numismatics as no member of staff has expertise in this area.
Is there access to external expertise? If so, who and in what areas? Yes – colleagues in other museums.


Supreme Court heads into the final month of its term with decisions yet to come on such divisive issues as immigration, abortion, and affirmative action. The person of interest in custody for the killing of three people at two Jewish centers is a former Ku Klux Klan leader with a history of antisemitism and racism, law enforcement officials said. New justice on the bench: It makes them queasy. Supreme Court unanimously rejected an effort to change political boundaries and reduce the voting strength of the nation's Latino population on Monday.
Here's how he justifies his actions:.
No Liquids on U. Virginia Democrats in disarray. The Justice Department announced charges against a year-old government contractor who a senior federal official says was the leaker of a top-secret National Security Agency document on Russian hacking. The year-old from Indiana was arrested at an Indianapolis bus station headed to New York with a plane ticket to Morocco. President-elect Donald Trump meets with leaders in Washington to begin his transition to the White House. We look at target killings, GOP internal battles and Dept.


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Olivia Newton-John's Former Boyfriend Again Rumored To Be Alive
By Cody LaGrow
Olivia Newton-John's former boyfriend Patrick McDermott reportedly went missing on a fishing trip. He was presumed dead after years of searching.
It seems an Australian tabloid is stirring the pot filled with a decade's worth of rumors that Olivia Newton-John's former boyfriend Patrick McDermott is still alive after he was widely believed to have died 10 years ago.
"Right from the start, investigators wondered whether McDermott decided to walk away from his life and was actually alive and well," said Inside Edition.
McDermott went missing during a fishing trip off the coast of California in 2005. After years of searching, the Coast Guard said McDermott "likely drowned." Now, the tabloid Woman's Day says he's living in rural Mexico with a German national.
The tabloid alleges McDermott could have fled for money troubles since he owed $30,000 in unpaid debts, including $8,000 in child support to his ex-wife, Yvette Nipar. His death would've left $100,000 from a life insurance policy to his son. The case was so bizarre, NBC's "Dateline" investigated the incident in 2009.
"He's not one that would make a stupid mistake and fall off a boat?" asked an investigator.
"No, I don't think he would," answered the acquaintance.
Newton-John has yet to comment on the latest rumors of her former boyfriend's existence. She has since married John Easterling, whom she wed in 2008.
This video includes clips from Inside Edition and Dateline and images from Getty Images.
Chuck Burton / AP


The Top 10 Prospects From 2015 | Where Are They Now?
The 10 Prospects From 2015 | Where Are They Now? In this video we look at the top players players on the espn 100 from the class of 2015. Some players went on to become nba stars such as Ben Simmons and some went on to be busts.
The Bust Of The Draft From The Last 5 Seasons | Where Are They Now?
The Steal Of The Draft From The Last 5 Seasons | Where Are They Now?
The Truth About Michael Porter Jr. | Rookie Of The Year Next Season?
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What NBA Draft History Tells Us About Lamelo Ball's Future | Will He Make The NBA?
5 Busts From The 2011 NBA Draft | Where Are They Now?
He Cooked Lamelo Ball In High School | Where Is Spencer Freedman Now?
He Was The Face Of The Biggest College Basketball Scandal | Where Is Brian Bowen Now?
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Redrafting The 2017 NBA Draft | Who Goes Number One?
What Happened To Jelly Fam? | Can Isaiah Washington Make The NBA?
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