text:
'I just want to get on with my ...
Clarke, Charlotte L. Wilkinson, Heather Watson, Julie Wilcockson, Jane Kinnaird, Lindsay and Williamson, Toby 2018. A Seat Around the Table: Participatory Data Analysis With People Living With Dementia. Qualitative Health Research, Vol. 28, Issue. 9, p. 1421.
February 2018 , pp. 378-402
'I just want to get on with my life': a mixed-methods study of active management of quality of life in living with dementia
CHARLOTTE L. CLARKE (a1), SARAH E. KEYES (a1), HEATHER WILKINSON (a1), E. JOANNA ALEXJUK (a1), JANE WILCOCKSON (a1) (a2), LOUISE ROBINSON (a3), JOANNA REYNOLDS (a4), SIOBHAN MCCLELLAND (a5), PHILLIP HODGSON (a2), LYNN CORNER (a3) and MIMA CATTAN (a4)...
* School of Health in Social Science, University of Edinburgh, UK.
† Department of Healthcare, Northumbria University, Newcastle, UK.
‡ Institute of Ageing & Health, Newcastle University, Newcastle upon Tyne, UK.
§ Department of Public Health and Wellbeing, Northumbria University, Newcastle, UK.
|| Health Economics & Policy Research Unit, Glamorgan University and Macmillan Cancer Support, London, UK.
DOI: https://doi.org/10.1017/S0144686X16001069
The active management of the experience of living with dementia appears to improve quality of life despite the lack of disease modification. However, research to date has been largely of modest scale and explanatory factors for improvements have been under-conceptualised. Thus, although promulgated through national strategies, the evidence base is relatively weak. This paper reports on a nation-wide study of the influence of the National Dementia Strategy for England in relation to Dementia Adviser and Peer Support Network services in 40 demonstration sites. The research aimed to identify ways in which the services contribute to the wellbeing and resilience of people with dementia and care partners. A mixed-methods research design collected data through: activity and outcome monitoring; organisational surveys; in-depth case studies, including qualitative interviews with people with dementia (N = 47) and care partners (N = 54), wellbeing and quality of life measures, and interviews with staff and other stakeholders (N = 82). Three themes are explored: addressing individual and community needs; promoting independence, control and choice; and getting a life back. Services promoted independence, control and choice, and consequently enabled people to re-narrate their lives as purposeful within their communities. Ways in which these are achieved resemble the public health model of lay health advisor and this research adds to the imperative to approach dementia as a key public health concern.
Address for correspondence: Charlotte Clarke, School of Health in Social Science, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK E-mail: charlotte.clarke@ed.ac.uk
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URL: /core/journals/ageing-and-society
dementia advisers


text:
Q: pd.iterrows() consume all the memory and gives an error (Process finished with exit code 137 (interrupted by signal 9: SIGKILL)) I have a csv file with with over 750000 row and 2 columns (SN, state).
The SN is serial number from 0 to ~ 750000 and the state is 0 or 1
I'm reading the csv file in pandas, then read .npy file with the same name as SN, then append the .npy files to 2 list named (x_train, x_val)
x_val should be 2000 element which 700 should be state = 1, and the rest is state = 0.
x_train should take the rest.
The problem is that after it reads about ~190000 rows the process stopped and the RAM is consumed (PC RAM = 32 GB)
x_train len=  195260
Size of list1: 1671784bytes
Process finished with exit code 137 (interrupted by signal 9: SIGKILL)

My code is :
nodules_path = "~/cropped_nodules/"
nodules_csv = pandas.read_csv("~/cropped_nodules_2.csv")

positive = 0
negative = 0
x_val = []
x_train = []
y_train = []
y_val = []

for nodule in nodules_csv.iterrows():

    if nodule.state == 1 and positive <= 700 and len(x_val) <= 2000 :
        positive += 1
        x_val_img = str(nodule.SN) + ".npy"
        x_val.append(np.load(os.path.join(nodules_path,x_val_img)))
        y_val.append(nodule.state)

    elif nodule.state == 0 and negative <= 1300 and len(x_val) <= 2000:
        x_val_img = str(nodule.SN) + ".npy"
        negative += 1
        x_val.append(np.load(os.path.join(nodules_path,x_val_img)))
        y_val.append(nodule.state)

    else:

        if len(x_train) % 10000 == 0:
            gc.collect()
            print("gc done")
        x_train_img = str(nodule.SN) + ".npy"
        x_train.append(np.load(os.path.join(nodules_path,x_train_img)))
        y_train.append(nodule.state)
        print("x_train len= ", len(x_train))
        print("Size of list1: " + str(sys.getsizeof(x_train)) + "bytes")

I tried to use the following:

*

*calling gc manually

*using df.itertuples()

*using dataframe apply()
but the same problem happen after ~100000 rows.
I tried to do pandas vectorization, but I didn't know how to do it, and I think these conditions couldn't be done using vectorization.
Is there any better way to do it than this one ?
I tried to implement chunks as @XtianP suggested
with pandas.read_csv("~/cropped_nodules_2.csv", chunksize=chunksize) as reader:
    for chunk in reader:
        for index, nodule in chunk.iterrows():
            if nodule.state == 1 and positive <= 700 and len(x_val) <= 2000 :
........

but the same exact problem happened! (maybe my implementation was not correct)
Maybe the problem is not with the pandas iterrows, but with the list getting oversize!
But the sys.getsizeof(x_train) output is only Size of list1: 1671784bytes
I've used tracing memory allocation as follow:
import tracemalloc

tracemalloc.start()

# ... run your application ...

snapshot = tracemalloc.take_snapshot()
top_stats = snapshot.statistics('lineno')

print("[ Top 10 ]")
for stat in top_stats[:10]:
    print(stat)

the results are :
[ Top 10 ]
/home/mustafa/.local/lib/python3.8/site-packages/numpy/lib/format.py:741: size=11.3 GiB, count=204005, average=58.2 KiB
/home/mustafa/.local/lib/python3.8/site-packages/numpy/lib/format.py:771: size=4781 KiB, count=102002, average=48 B
/usr/local/lib/python3.8/dist-packages/pandas/core/indexes/base.py:4855: size=2391 KiB, count=102000, average=24 B
/home/mustafa/home/mustafa/project/LUNAMASK/nodule_3D_CNN.py:84: size=806 KiB, count=2, average=403 KiB
/home/mustafa/home/mustafa/project/LUNAMASK/nodule_3D_CNN.py:85: size=805 KiB, count=1, average=805 KiB
/usr/local/lib/python3.8/dist-packages/pandas/io/parsers.py:2056: size=78.0 KiB, count=2305, average=35 B
/usr/lib/python3.8/abc.py:102: size=42.5 KiB, count=498, average=87 B
/home/mustafa/.local/lib/python3.8/site-packages/numpy/core/_asarray.py:83: size=41.6 KiB, count=757, average=56 B
/usr/local/lib/python3.8/dist-packages/pandas/core/series.py:512: size=37.5 KiB, count=597, average=64 B
/usr/local/lib/python3.8/dist-packages/pandas/core/internals/managers.py:1880: size=16.5 KiB, count=5, average=3373 B

redpajama_set_name: RedPajamaStackExchange


text:
News > Blogs > SoA Blog > October 2019 > Taking PLR international
Taking PLR international
September 2019 marked the 40th anniversary of the establishment of PLR for authors. Jim Parker looks at what's happening overseas.
It is now 40 years since UK authors won the legal right to receive payment from government to compensate them for the free lending out of their books by public libraries.
The passing of the Public Lending Right (PLR) Act in the UK in 1979 was the result of a 20-year struggle, led by the Writers' Action Group – notably Brigid Brophy, Maureen Duffy, Francis King and Ted Willis, with support from many other writers, and of course the SoA.
The UK was not the first country to establish PLR, however. That was Denmark in 1946, followed by Norway in 1947 and Sweden in 1954. And even then, it was not a new idea. A resolution passed at the Nordic Authors' Association meeting in 1919 called on governments to compensate authors for library lending of their books.
Currently 34 countries across the world have PLR systems, all but four of which are in Europe. (Outside Europe the first PLR system to be established was in New Zealand in 1973, followed by Australia in 1974, and then Canada and Israel in 1986.) Around 26 other countries recognise the legal right of authors to license the lending out of their works but have not yet set up systems to enable authors to be remunerated. This can be where there is no authors' organisation in place to administer a PLR system, or where book lending by public libraries – the essential component in most PLR systems – has been excluded in legislation from any PLR obligation.
PLR continues to spread. The most recent system to get up and running is in Poland, where the first payments to authors for the lending out of their books by public libraries were made in 2016.
"Currently 34 countries across the world have PLR systems, all but four of which are in Europe."
Recognising rights
European Union Member States are required by law to set up PLR systems. The Rental and Lending Right Directive (1992, reconstituted in 2006) gives authors and other rightsholders an exclusive right to license or prohibit the lending of their works by libraries. However, Member States may opt out of an exclusive right provided that they remunerate authors for the loan of their works. Member States must include public libraries in their PLR schemes but are permitted to exclude the lending of authors' works from other categories of library.
Outside the EU, lending right is not a requirement under international copyright law. As a result, there are no PLR systems yet in Africa, South America or Asia, and indeed the only countries outside Europe operating PLR systems are Australia, Canada, New Zealand and Israel. But things are changing. A PLR campaign has been launched in the US by the Authors' Guild. Malawi, Zanzibar and Greece have recently introduced PLR legislation and are preparing to set up schemes; and draft copyright legislation in Turkey making provision for PLR awaits ministerial clearance before being submitted to parliament.
PLR can also function as part of a country's support structure for its own culture and language. So in several European countries (e.g. Denmark, Sweden and Norway) PLR is not covered by copyright law, and is only payable to authors writing in the national language(s) of that country. Outside Europe, the PLR systems in Australia and Canada exist to support authors who are nationals of those countries.
Generally speaking funding for PLR payments is provided by regional or central government and is not taken from library budgets. The principle that PLR payments should be the responsibility of government and not be a burden on libraries is one that we advocate everywhere.
"The principle that PLR payments should be the responsibility of government and not be a burden on libraries is one that we advocate everywhere."
There are two main approaches to administration. In countries such as Germany, the Netherlands, Spain, the Slovak Republic and Lithuania, PLR is managed by a collective management organisation (CMO) alongside other rights subject to licence like photocopying. (The writers' CMO in the UK is ALCS.) In other countries PLR is a right with its own legislation and is administered by a government body. So in the UK, PLR is administered by the British Library. PLR remuneration systems can also be funded directly by government without any legislative basis (as in Canada, Malta and Israel) but this of course can leave them vulnerable to closure.
Most commonly, PLR is distributed to authors in the form of payments related to how often their works have been lent out by libraries. The UK uses this payment-per-loan approach. Alternatively, payment can be made to authors in line with how many copies of their books are held by libraries – the stock, or title, count method is used in Canada, Denmark and Australia. In France, part of the overall PLR fund comes from a small payment made by suppliers when they sell a book to a library. The remaining part of the PLR fund is made up by a small fee paid by the government for every registered library user.
Many countries combine elements from different approaches. In Slovenia, for example, PLR payments are made to authors for loans of their books but PLR funding is also used to provide study grants and scholarships. In addition to writers, other contributors to books such as illustrators, translators, editors and photographers commonly qualify for PLR payments; and in several countries publishers share the PLR payments with the authors.
PLR payments make a real difference to authors' lives. In the UK around 24,000 writers, illustrators and translators receive payments of up to a maximum of £6,600 each year.
For many, particularly writers who are not among the bestsellers, this is their biggest source of income in an age when authors' incomes from publishing are falling everywhere. PLR can be a life-saver for writers with long backlists of published works that remain available for loan in public libraries even though the books may be out of print. In France and Germany PLR funds are used to provide pensions for authors.
In some countries it can also be bequeathed at an author's death to his/her family for up to 70 years. And PLR is not just restricted to public library loans of authors' works. In Australia the Educational Lending Right makes payments to authors for the presence of their books in school libraries. In Germany higher education libraries are included in PLR.
Some of the benefits are not financial. Many authors in the UK find that the details provided by the PLR office showing how often their books have been borrowed from public libraries are a great morale booster – especially when the loans relate to an older book no longer available in the shops.
In the words of author Tracy Chevalier: 'PLR is about more than money, though of course that is welcome. Getting my cheque each year is a reminder that people want to read my books rather than simply own them.'
This article was originally published in the 2019 Autumn issue of The Author.
© Chinnapong / Adobe Stock
About Jim Parker
Dr Jim Parker is the former Head of PLR in the UK and is now Co-ordinator for the International PLR Network (www. plrinternational. com), which facilitates the exchange of best practice and provides technical assistance to countries looking to set up PLR systems. An earlier version of this article appeared in the magazine of the World International Property Organisation (WIPO).
To find out more about PLR, click here.
Read the SoA's 40th birthday to PLR here.
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text:
The Lowdown on Employer-Sponsored Retirement Plans
Kara Perez
6 second take: Retirement might be decades away, but it's never too early to start saving. Save early, and you set yourself up nicely. Save late, and you'll be playing catch up.
Luckily, some workplaces can make it easy for you to save for retirement from your first day on the job. Employer-sponsored retirement plans like the 401(k) and the 403(b) are designed to help you save money easily for your future self.
What Is a 401(k)?
The 401(k) is the granddaddy of retirement plans. You can arrange to fund this retirement savings plans, sponsored by your employer, through your paycheck, meaning pretax contributions are taken directly from your check and deposited in your 401(k).
You pay taxes on the money saved once you begin to withdraw funds from the account in retirement or anytime after age 59½. (You can take money out before retirement, but you'll pay a 10 percent penalty tax in addition to any other taxes you'll owe in your state.) Contributions to a 401(k) are not tax deductible, but there is a perk: The money you contribute to your 401(k) doesn't count as income, so you're not taxed on it.
As the owner of the account, you decide where that part of your paycheck goes. Most plans offer investment opportunities in stocks, bonds, and money market funds. The details of your plan should be laid out for you in your hiring paperwork or by your human resources department.
See How Your 401(k) Stacks up in Minutes — Start by Getting Your Free Analysis >>
What Is a 403(b)?
A 403(b) is similar to a 401(k), but it's for people in the nonprofit arena, public schools, health service cooperatives, and certain types of employees of religious institutions. (See the complete list of eligible people on the IRS website.) This plan is commonly described as the 401(k) for nonprofit industries. Contributions to a 403(b) are tax deductible.
Both the 401(k) and the 403(b) must be set up by an employer.
Benefits of Employer-Sponsored Retirement Plans
A great perk that comes through employer-sponsored retirement plans like the 401(k) and the 403(b) is that some companies offer contribution matches. If you sign up for this, the company will then match the amount of money that you contribute to your 401(k) from your salary.
The exact amount varies from company to company but is generally from one to seven percent of your contribution. Say you have a two percent match. If you contribute two percent of your $60,000 salary (or $1,200), the company will throw in another $1,200 for a total contribution of $2,400.
Company matches are essentially free money — a phrase you'll often hear from people who take their companies up on matching. You put in a certain percentage of your salary and your company contributes the same amount at no cost to you.
"I was fortunate enough to be able to contribute as an intern, so I started contributing from Day One with my company," says Gwen, a 27-year-old who has participated in her company's 401(k) for years. "My contribution is matched like so: The first two percent is matched 300 percent, then 100 percent up to six percent, for a total of 10 percent. I contribute because it lowers my taxable income and allows me to save money and because the match is free money."
Gwen's match may sound complicated, but it follows the same formula we talked about earlier. She contributes 10 percent of her paycheck to her 401(k), and her company matches it. It's just that a sliding scale is used for those who don't contribute the whole 10 percent, like Gwen.
Manage Your 401(k) Today — Start by Getting Your Free Analysis >>
Christine, 33, has a 403(b) through her job. She also opted in from her first day, seeing the plan as a way to save for the future and optimize her taxes in the present.
"I opted in to my company's 403(b) so that I can take advantage of an easy way to invest in some tax-sheltered retirement savings," Christine says.
"I've had a 401(k) as well as a TSP [a thrift savings plan for federal employees] before, and a 403(b) feels no different. I have it set up to take a specific percentage of my paycheck each biweekly pay period. We do have a company match, and I always max that out. Hello, free money!"
But I'm 25 — I Don't Need to Think About Retirement, Right?
If you're nowhere near retirement age, you might think there's no need to contribute to your workplace retirement plan. That's a common assumption, but it's the wrong financial move. There are two big reasons you want to take advantage of an employer-sponsored retirement plan when you're young.
The first is a little something called compound interest. All money nerds love to talk about it, and for good reason: Compound interest is honest-to-goodness financial magic. It's money that you earn on the amount of money you contribute to your retirement plans and on the interest that you earn on those accounts. It's twice the return for half the work.
Here's an example: You invest $1,000 a year in your 401(k). For the sake of easy math, let's say you get a 10 percent rate of return. So in your first year, you earn 10 percent on that $1,000, which brings your total to $1,100.
The next year you earn 10 percent on $2,100, an amount that reflects your second $1,000 contribution to the plan plus the interest you earned last year. Your interest compounds — it begins to earn money on itself and any additional contributions you make.
The earlier you start to invest, the more time your money has to compound. Obviously, if you start investing at 25, you'll have more money than if you start investing at 35.
More Reasons to Take Advantage of Employer-Sponsored Retirement Plans
The second reason you should care about retirement savings early is our economic system. Retirement income used to be made up of Social Security benefits, personal savings, and pensions. But fewer workers will get the benefit of secure pensions in the future, and more people are drawing on Social Security than are contributing to it. This means that your post-retirement financial security comes down mostly to your personal savings.
Fortunately, the magic of compound interest means that you don't have to do all of the saving by yourself. Again, your money does some of the saving for you. Without compound interest, your contributions would be all you had.
Employer-sponsored retirement plans are a great way to prepare for the future and start you on investing. Take advantage of the options offered by your job to protect your finances.
How to Save Money Fast: My Plan to Own a Home
I Don't Want to Have Children (Ever) — Here's Why
What Happens If You Don't File Taxes?
Retirement Quiz: Challenge Your 401(k) Smarts!
By: Allison Martin
How a Health Savings Account Can Help You Retire
By: Myles Ma
When to Start Saving for Retirement (It's Sooner Than You Think)
By: Sarah Sharkey
4 Employee Benefits That Help You Save Money
By: Lance Cothern
Retirement Savings: Roth vs. Traditional — Simplified!
Saving for Retirement: 401(k)itchen With Min Fin


and could be mapadd script loaded (removing, modifying) before spawn entities.
Because some enties are impossible remove or modify for example template entities.
Or if you need modify classname info_player_rebel to info_player_deathmatch, then change it but spawn don't work and is enabled.
Additional Information I know it can be replaced with stripper:source for now, but better will be single system.


I have Foundations Teacher's Manuals A, B and C. Where can I go to learn more? Is there a training video I missed? I have the Teacher's Training Manual, too.
Dictation is the most challenging writing/spelling practice students do in Foundations. It's more challenging than spelling individual words, because you have to hold the sentence in your head; on the other hand, it is easier than free writing because you don't have to make up the sentence (and, at least in LOE curriculum, because it's carefully controlled for words you know how to spell).
The steps are pretty straightforward, and they are explained in lesson 84 at the first dictation exercise (p. 21 of the Foundations C Teacher's Manual). You repeat the sentence twice, and then the student says it and then writes it. She then reads it back to you and gives all the spelling/writing tips she had to think about as she wrote. You write it on the board with her 'help.' Write it correctly even if she makes any mistakes. Discuss any questions or discrepancies and have her correct hers.
As the instructions model, you normally say the sentence twice. But if she needs you to say it more times before she can repeat it confidently, do it!
The goal is that you would not have to give it to her word by word, since the point of the exercise is to get better at holding the phrase in her head while also spelling, since that's what you have to do to free write - but if she needs smaller chunks at first, by all means give them!
You definitely do not want to allow her to see the sentence beforehand; this is where she practices the skill of thinking of a sentence, sounding it out in her head, and writing it. This is a key skill for all future writing work.
The goal of dictation is to practice this skill, not necessarily to spell every word correctly every time. They will all be words that she can understand the spelling of, but that doesn't mean she'll always remember which spelling of a particular sound is used in a particular word; this takes more time, and she is still learning. This is not a problem. The part where you write it and she corrects hers is part of the exercise.
If she asks for clarification on a specific word, there's nothing wrong with cuing it as you do in spelling analysis, with a verbal cue ("use /k-s/") or finger spelling, to remind her how to spell it correctly. But it's probably more important to communicate that she is just practicing and doesn't have to get every word perfectly; it's expected that she'll make some errors that you'll then correct together.
In Essentials, dictation has the same goal and works the same way as in Foundations. After learning new words through Spelling Analysis and practicing them individually through games, students later practice words through dictation of short phrases and eventually sentences, a more challenging task that prepares them for independent composition. The biggest difference with Essentials is that students do dictation more often, since there is a greater emphasis on developing spelling mastery at this level. Each lesson in Essentials 2nd edition includes a short dictation practice in Day 3 and another in Day 4, as well as dictation in the Check Your Understanding assessment on Day 5. There are three levels of dictation activities in each section, built on the words in three levels of spelling lists in Essentials lessons.
In Foundations, note that there are three line sizes on each Dictation page in the workbook. Allow students to choose the line size they prefer. Students may also complete Dictation sentences on a whiteboard.
Since the increased challenge of dictation is a big step for Foundations students, at this level students practice the same sentence as copywork beforehand. The goal is not that they memorize this sentence, but simply to give them increased familiarity and practice with these words so that they are more able to be successful when they move to dictation. In Essentials, students hear the phrases for the first time when they write them in dictation exercises, but they progress gradually from short phrases to longer phrases and then sentences over the course of the lessons.
Learn more about Finger Spelling and the process of teaching words through Spelling Analysis.


A project is a logical container that contains group of articles arranged under relevant categories and sub-categories and with relevant settings for your software product.
You can create a project for a software, say ACME, as acme.document360.io. Within the project, you can organize your articles into multiple categories and sub-categories. If you are a partner or a consulting company, you can create individual projects for each of your customers and maintain the documentation with ease.
You first need to create a project in Document360 in order to be able to write your documentation.
If you are logging in for the first time into Document360, you will be prompted to create a new project. You need to provide the project name, sub-domain name, and upload a logo image/add logo text. The sub-domain name will be automatically populated with the name entered in the project name field. You can choose to retain the same name or change the value.
You cannot edit the project name and sub-domain name once you have created the project.
If you are in the trial plan, you will be able to create only one project. You will see an error message asking to upgrade your subscription to be able to add more projects.
Navigate to Settings. In the Project General Settings section, click the Delete Project button.
Enter the sub-domain name of the project in the space provided. Only upon successful validation, you will be able to click the Delete button to delete the project.
Once the project is deleted, you can create a new project based on your requirement.
If you need to create another new project with same settings and configuration of an existing project then you can clone the desire project. Cloning the project will take copy of source project and create one seperate project.


Idyllic Minorcan house located in a privileged area of the small rural village of Llumaçanes, a short distance from the capital Mahón. Its original interior preserves all the features of an authentic house with a lot of charm. As soon as you enter, there is a large arched space consisting of a spacious living room with a cosy fireplace and a cast iron Jotul woodburning stove and adjoining dining room area. Also on the ground floor, we find the large master en-suite bedroom, a single bedroom and a separate bathroom. The beautiful kitchen with its original design and nice dining area, has direct access to the outside.
At one end of the house, there is a room ideal for guests, with its own bathroom, and its private entrance from the garden. On the first floor, the beautiful hall, distributes on one side to the area with a total of 3 double bedrooms, all with views of the garden, a single room and a bathroom. On the other side it leads us to an impressive living room with large fireplace and own terrace. The property has a garage and an exterior bathroom. The spacious garden also has a pleasant covered area with original details, such as the typical white built-in benches and a barbecue area, completing the outdoor areas and to enjoy at the fullest.


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About Cheryl McCollum
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Living out a dream: Decorating a float for the Rose Parade


A brown owl called Chocolate.
Her recurve bow and arming sword that she always wears .
A recurve bow with Elven script on it in her room.
A stuffed small deer and makani figures.
Ayda (Ayda ) - Thanking you for giving me a home and family. I will try to make you proud and not regret doing so.
Cassian ( Baron2537 ) - I hope three's a charm as you are now pappa number three of adopted pappa's. I want you and momma proud of me. I love my new family.
Raalvara (Raal ) - You are like another mother to me.. I feel sad that you believe I betrayed you.
James (TheDeester )- I thank you for accepting me as family.. I will do my best to protect you, Raalvara and Katla.
Glynn (Raal) - Thank you for being willing to accept me as a daughter. I will try to live up to that honor.
Derek-I love you little bro and will look after and protect you.
Kitrana (godfather1 ) - You are now my aunt I hope to make you proud.
Laisa (Samiwashere )- You grew faster then me and you seem to out grow our camaraderie as well.
Andre (UmbraSicarius ) -You are nice to me and I thank you for that. I also hope to make you proud when you teach me.
Sugar (Ruu )- I like you Very much.You try to keep me safe and give me cupcakes. You are also helping me learn. Thank you.
Leofaren ( Shankster )- You seem nice but I don't think Daddy likes you much.
Theodosius (Blorbis83 )-Why did you send me away.. You still see Dimi but not me.. You lie to me when you said you loved me, You confuse me when you now talk but yet you can not tell me why you sent me away.
Garret (Galaxy )- I am glad to see what a fine young man you are growing into.
Leontius (AmparoCastaway )- Thank you for accepting me as a sister.you make me smile to.
Sylleth (Angel ) - I am glad we met. She is a silver elf girl like me and we have fun. She is very pretty.
Cedlas (Swiftspear ) - I am glad you brought me away from that mean man. But I don't like how you changed drawing a bow on me.
Violet (MelodyComplex )- I Love you alot. You are fun. I hope you like me too. I miss you. Come home soon. Please come to see me.
Kaelin (Edouard2000 ) - I like you. You seem fun. We shall see more with time.
Azure (Immerael )- You are nice like Miss Nireth. I like your stories.
Julianus (Sir_Arc ) - I am glad to call you uncle. you are fun when you want to be.. Seems like Lin gets all of the fun now though. I hope you still love me.
Carling (MelodyComplex )- Thank you for trying to protect me. I am sorry she hit you. I love you and will keep you safe if I can. I miss you Lin.
Citrine (Samiwashere )- I like you. You are funny when you have to much to drink yet you are very pretty and gave me chocolate candy.
Arianne (Bobert )- You made Lin go away when she was sick, she almost died because of you. You are a mean doctor.
Cyra'Tina (Immerael )- Another girl like me. She likes adventures too. Maybe in time we can be friends.
Jerr'co (The Tottot ) - You seem like you might be a nice man. Maybe I can get to know you better.
Vashti (Charybdis ) - I am unsure about you I just know you dislike me for some reason.
Virnaak (Vincentius ) - You seem okay.. Just need to not let Vashti control you so much.
Gilligan (Samwych ) - I think you are a very nice person.
Kopii (Omikuji ) - I think I could make you proud if given a chance.
Jaden (CloakedReaper ) - You are my adopted grandfather yet you still won't give me a chance at being a ranger or even a recruit.
Asiria Warren (ArkianDragon ) - You are a nice lady who I like alot.. I believe though you work to hard.
Yasmine (ArkianDragon )- You try to hard to be liked.. Relax and enjoy those who care for you.
Elwin (Rang3r0wns94 ) - you are a good kid even if you do get hurt alot.
Thordil (Jazzper ) - Thank you for helping me as a kid.. The sword has become my favorite.
Jhearos (Rang3r0wns94 ) - I thank you for the spear and helmet.
Peter (Djiboutian ) - I dislike you. You wanted me to be a servant just because I wanted a drink. Then you scare me with threats of giant scorpions and bandits.
Derric (LeeroyVengeance ) - You are a nice man and I thank you for the dagger and friendship.
Chimi (Maestroart )- I enjoyed or time together but now I don't see you. i wish you would come back.
Nessa (frenchrainbow )- I like you even if you don't like the rain. You seem very nice but you seem to busy now to visit.
Nylas (Swiftspear )- I thought we could be friends but I don't trust you after what you did.
Celestia (MeowCow_ )- You said you would teach me. I will prove to you I am a good girl and Theo was right for giving me a chance.
Titania (Old-Seadog )- You seemed to put me down at first. Maybe not. I want to get to know you. You hit me and are mean.
Eastoft (Mapboy ) - You seem friendly but always in a rush. Maybe with time we will be friends.
Chives (Treeboy )- Thank you for the pretty flower crown. Good luck with Mister Boe.
Ayre (MeowCow_ ) - You seem nice and I know you wanted to help me too.
Geralt (Zombie3255 ) -You seem nice. I hope Nylas listens for you.
Rosamonde (Rosamonde )- You seem nice. You have a pretty smile.
Bertrand (Bowduim )- thank you for the pretty brooch.
Warren (ArkianDragon )- you seem nice but you need more practice at swordfighting.
Mirielle (Bertie99R) -I enjoyed helping you learn..keep up the practice.
Peter (Sir_Arc ) - I know you was trying to help but things was and are complicated. Take care of Faer. I hope in time my feelings change back for them.
Evanline (Maestroart )- You are now my sister. Hopefully we can know each other better.
More relations and an update on one.
Updates. If I forgot anyone poke me.
Update for Lin and Violet?
Jo and maybe updated Theo relation?


text:
Типтон () је округ у америчкој савезној држави Тенеси.

Демографија
По попису из 2010. године број становника је 61.081, што је 9.81 (19,1%) становника више него 2000. године.

Референце

Литература

Види још
 Округ
 Спискови округа САД

Спољашње везе

 -{United States Census Bureau}-

Окрузи Тенесија

redpajama_set_name: RedPajamaWikipedia


text:
A conserved biogenesis pathway for nucleoporins: Proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96
Beatriz M A Fontoura, Günter Blobel, Michael J. Matunis
Cell Biology - Division F
The mammalian nuclear pore complex (NPC) is comprised of ~50 unique proteins, collectively known as nucleoporins. Through fractionation of rat liver nuclei, we have isolated >30 potentially novel nucleoporins and have begun a systematic characterization of these proteins. Here, we present the characterization of Nup96, a novel nucleoporin with a predicted molecular mass of 96 kD. Nup96 is generated through an unusual biogenesis pathway that involves synthesis of a 186-kD precursor protein. Proteolytic cleavage of the precursor yields two nucleoporins: Nup98, a previously characterized GLFG- repeat containing nucleoporin, and Nup96. Mutational and functional analyses demonstrate that both the Nup98-Nup96 precursor and the previously characterized Nup98 (synthesized independently from an alternatively spliced mRNA) are proteolytically cleaved in vivo. This biogenesis pathway for Nup98 and Nup96 is evolutionarily conserved, as the putative Saccharomyces cerevisiae homologues, N-Nup145p and C-Nup145p, are also produced through proteolytic cleavage of a precursor protein. Using immunoelectron microscopy, Nup96 was localized to the nucleoplasmic side of the NPC, at or near the nucleoplasmic basket. The correct targeting of both Nup96 and Nup98 to the nucleoplasmic side of the NPC was found to be dependent on proteolytic cleavage, suggesting that the cleavage process may regulate NPC assembly. Finally, by biochemical fractionation, a complex containing Nup96, Nup107, and at least two Sec13-related proteins was identified, revealing that a major sub-complex of the NPC is conserved between yeast and mammals.
https://doi.org/10.1083/jcb.144.6.1097
Nuclear pore complex
Nucleocytoplasmic transport
Nucleoporin
Proteolytic cleavage
RNA export
10.1083/jcb.144.6.1097
Dive into the research topics of 'A conserved biogenesis pathway for nucleoporins: Proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96'. Together they form a unique fingerprint.
nuclear pore complex protein 96 Medicine & Life Sciences 100%
nuclear pore complex protein 98 Medicine & Life Sciences 80%
Nuclear Pore Complex Proteins Medicine & Life Sciences 68%
Nuclear Pore Medicine & Life Sciences 39%
Protein Precursors Medicine & Life Sciences 14%
Immunoelectron Microscopy Medicine & Life Sciences 7%
Saccharomyces cerevisiae Medicine & Life Sciences 5%
Fontoura, B. M. A., Blobel, G., & Matunis, M. J. (1999). A conserved biogenesis pathway for nucleoporins: Proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96. Journal of Cell Biology, 144(6), 1097-1112. https://doi.org/10.1083/jcb.144.6.1097
A conserved biogenesis pathway for nucleoporins : Proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96. / Fontoura, Beatriz M A; Blobel, Günter; Matunis, Michael J.
In: Journal of Cell Biology, Vol. 144, No. 6, 22.03.1999, p. 1097-1112.
Fontoura, BMA, Blobel, G & Matunis, MJ 1999, 'A conserved biogenesis pathway for nucleoporins: Proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96', Journal of Cell Biology, vol. 144, no. 6, pp. 1097-1112. https://doi.org/10.1083/jcb.144.6.1097
Fontoura BMA, Blobel G, Matunis MJ. A conserved biogenesis pathway for nucleoporins: Proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96. Journal of Cell Biology. 1999 Mar 22;144(6):1097-1112. https://doi.org/10.1083/jcb.144.6.1097
Fontoura, Beatriz M A ; Blobel, Günter ; Matunis, Michael J. / A conserved biogenesis pathway for nucleoporins : Proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96. In: Journal of Cell Biology. 1999 ; Vol. 144, No. 6. pp. 1097-1112.
@article{ea16cc789f1d4bbab7188951dfb4579e,
title = "A conserved biogenesis pathway for nucleoporins: Proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96",
abstract = "The mammalian nuclear pore complex (NPC) is comprised of ~50 unique proteins, collectively known as nucleoporins. Through fractionation of rat liver nuclei, we have isolated >30 potentially novel nucleoporins and have begun a systematic characterization of these proteins. Here, we present the characterization of Nup96, a novel nucleoporin with a predicted molecular mass of 96 kD. Nup96 is generated through an unusual biogenesis pathway that involves synthesis of a 186-kD precursor protein. Proteolytic cleavage of the precursor yields two nucleoporins: Nup98, a previously characterized GLFG- repeat containing nucleoporin, and Nup96. Mutational and functional analyses demonstrate that both the Nup98-Nup96 precursor and the previously characterized Nup98 (synthesized independently from an alternatively spliced mRNA) are proteolytically cleaved in vivo. This biogenesis pathway for Nup98 and Nup96 is evolutionarily conserved, as the putative Saccharomyces cerevisiae homologues, N-Nup145p and C-Nup145p, are also produced through proteolytic cleavage of a precursor protein. Using immunoelectron microscopy, Nup96 was localized to the nucleoplasmic side of the NPC, at or near the nucleoplasmic basket. The correct targeting of both Nup96 and Nup98 to the nucleoplasmic side of the NPC was found to be dependent on proteolytic cleavage, suggesting that the cleavage process may regulate NPC assembly. Finally, by biochemical fractionation, a complex containing Nup96, Nup107, and at least two Sec13-related proteins was identified, revealing that a major sub-complex of the NPC is conserved between yeast and mammals.",
keywords = "Nuclear pore complex, Nucleocytoplasmic transport, Nucleoporin, Proteolytic cleavage, RNA export",
author = "Fontoura, {Beatriz M A} and G{\"u}nter Blobel and Matunis, {Michael J.}",
doi = "10.1083/jcb.144.6.1097",
journal = "Journal of Cell Biology",
publisher = "Rockefeller University Press",
T1 - A conserved biogenesis pathway for nucleoporins
T2 - Proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96
AU - Fontoura, Beatriz M A
AU - Blobel, Günter
AU - Matunis, Michael J.
N2 - The mammalian nuclear pore complex (NPC) is comprised of ~50 unique proteins, collectively known as nucleoporins. Through fractionation of rat liver nuclei, we have isolated >30 potentially novel nucleoporins and have begun a systematic characterization of these proteins. Here, we present the characterization of Nup96, a novel nucleoporin with a predicted molecular mass of 96 kD. Nup96 is generated through an unusual biogenesis pathway that involves synthesis of a 186-kD precursor protein. Proteolytic cleavage of the precursor yields two nucleoporins: Nup98, a previously characterized GLFG- repeat containing nucleoporin, and Nup96. Mutational and functional analyses demonstrate that both the Nup98-Nup96 precursor and the previously characterized Nup98 (synthesized independently from an alternatively spliced mRNA) are proteolytically cleaved in vivo. This biogenesis pathway for Nup98 and Nup96 is evolutionarily conserved, as the putative Saccharomyces cerevisiae homologues, N-Nup145p and C-Nup145p, are also produced through proteolytic cleavage of a precursor protein. Using immunoelectron microscopy, Nup96 was localized to the nucleoplasmic side of the NPC, at or near the nucleoplasmic basket. The correct targeting of both Nup96 and Nup98 to the nucleoplasmic side of the NPC was found to be dependent on proteolytic cleavage, suggesting that the cleavage process may regulate NPC assembly. Finally, by biochemical fractionation, a complex containing Nup96, Nup107, and at least two Sec13-related proteins was identified, revealing that a major sub-complex of the NPC is conserved between yeast and mammals.
AB - The mammalian nuclear pore complex (NPC) is comprised of ~50 unique proteins, collectively known as nucleoporins. Through fractionation of rat liver nuclei, we have isolated >30 potentially novel nucleoporins and have begun a systematic characterization of these proteins. Here, we present the characterization of Nup96, a novel nucleoporin with a predicted molecular mass of 96 kD. Nup96 is generated through an unusual biogenesis pathway that involves synthesis of a 186-kD precursor protein. Proteolytic cleavage of the precursor yields two nucleoporins: Nup98, a previously characterized GLFG- repeat containing nucleoporin, and Nup96. Mutational and functional analyses demonstrate that both the Nup98-Nup96 precursor and the previously characterized Nup98 (synthesized independently from an alternatively spliced mRNA) are proteolytically cleaved in vivo. This biogenesis pathway for Nup98 and Nup96 is evolutionarily conserved, as the putative Saccharomyces cerevisiae homologues, N-Nup145p and C-Nup145p, are also produced through proteolytic cleavage of a precursor protein. Using immunoelectron microscopy, Nup96 was localized to the nucleoplasmic side of the NPC, at or near the nucleoplasmic basket. The correct targeting of both Nup96 and Nup98 to the nucleoplasmic side of the NPC was found to be dependent on proteolytic cleavage, suggesting that the cleavage process may regulate NPC assembly. Finally, by biochemical fractionation, a complex containing Nup96, Nup107, and at least two Sec13-related proteins was identified, revealing that a major sub-complex of the NPC is conserved between yeast and mammals.
KW - Nuclear pore complex
KW - Nucleocytoplasmic transport
KW - Nucleoporin
KW - Proteolytic cleavage
KW - RNA export
U2 - 10.1083/jcb.144.6.1097
DO - 10.1083/jcb.144.6.1097
JO - Journal of Cell Biology
JF - Journal of Cell Biology


Rhizome | Have You Never Been Mellow?
Rhizome | Mon Jun 10th, 2002 8 a.m.
From the hyper-meticulous crew at k10k.net comes moodstats, self-analysis software that lets users monitor and share moods. Track up to 5 categories daily (mood, creativity, chocolate intake, whatever) on a scale of 1-10. The software graphs moods over time, so users can analyze visually, recognize patterns, and presumably produce self knowledge. Feeling exhibitionistic? Publish your stats online, or download other people\'s stats and compare them to yours. moodstats for mac and PC: trial version free. full version $15.


In the Spring 2014, The Crown Inn was given a smart, contemporary facelift by new owners, Tom and Holly Strathmore when they re-opened the well-established hotel following a renovation of rooms, bar and restaurant. The prime location is right beside the harbour, with spectacular views over to Lews Castle and Museum, the ideal place to stay a short walk from the Ferry port and Bus Station.
The Hotel has a fascinating link to the Royal Family. In 1963, when aged 14, Prince Charles and four school friends arrived in Stornoway on board the Pinta, the Gordonstoun training ship, to have supper at the Crown followed by a movie at the Playhouse. Escaping attention from local journalists, Charles escaped to the Bar and when asked by the unsuspecting barmaid what he would like to drink, he ordered a cherry brandy. When it was revealed that the underage future King had been served alcohol, with his private detective absent from his royal duty, the story became a media sensation. While Charles was sent back to Gordonstoun to be reprimanded by the Head Master, the bar was nicknamed the "The Prince of Wales" to commemorate his visit.
Today, the most aptly named Crown Bar is a lively, buzzing place for hotel guests, locals and international tourists in town offering the style of a traditional hunting lodge with decorative Stag Heads and leather wing armchairs with the ambience of a chic cocktail bar and laid-back jazz-blues music on the soundtrack.
There's an impressive selection of drinks with a speciality Gin menu offering 115 brands from across Scotland, UK, Europe and the world, Whiskies, spirits, beers and well-priced wine list. The staff are knowledgeable and enthusiastic and will recommend a fine single malt, Harris gin or shake up a cool Martini.
Dinner is served either in the bar, if you prefer a more casual setting, or the Harbour View Restaurant next door. The menu is so inviting with the simple message "Let's Eat Dinner – fresh, local, produce." This is contemporary Bistro-style good food which celebrates Island seafood, meat, game and seriously, high quality homemade dishes such as a range of burgers – beef, chicken and vegetarian, chef's own Fishcakes, Lewis Lamb, Roast chicken and classic fish and chips: Hearty, healthy modern Scottish cuisine, for a true taste of the Hebrides.
Downstairs is the Harbour Bar for an alternative pub atmosphere complete with pool table and live music gigs and ceilidhs, where Stornoway folk will gather over a few drinks with hotel guests joining in the lively atmosphere.
Accommodation offers seventeen Bedrooms (from single to family), which are simply furnished with all the main essentials, comfortable mattresses, cosy duvets, soft towels, hot water in the shower, TV (wide choice of channels), Tea and Coffee tray – all you need for a good night's sleep.
Breakfast is exemplary with a cold buffet of fresh fruit and cereals and pastries and a great choice of hot dishes such as the full Scottish with eggs, bacon and Stornoway black pudding or Scrambled egg with Smoked Salmon.


ISCA's staff are based in Denmark, Slovenia, Bulgaria and Belgium. The ISCA Secretariat is located in the centre of Copenhagen and our staff are ready to assist you with your enquiries and requests.
If you want to get in touch with us, you can find email addresses for individual staff members below, or please click here to contact us at the Secretariat.


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Top StoriesWar on PhotographyCops Gone RogueCops In CuffsEye On GovernmentCitizen Journalism
War on Photography
Cops Gone Rogue
Cops In Cuffs
Texas Police Shot Man in Back, Disproves Police Claim
bycassandrarules
Texas Police Shot Man in Back, Autopsy Disproves Police Claim Victim "Charged At Officers".
The El Paso Police Department has maintained that Erik Salas Sanchez, 22, was shot for charging at police, however, the autopsy report has revealed that he was shot in the back.
The police claim that Sanchez had threatened them with a "metal object," and charged at the officers.
The cops allegedly attempted to tase Sanchez, but were unsuccessful, and that is when a 10-year-veteran Texas police officer opened fire with his service weapon.
Sanchez was shot three times, in the right side of his back, the left side of his back, and his buttocks. Quite a feat, as he was allegedly "charging at the officers."
He was then handcuffed despite the severe injuries, and died soon after at the Del Sol Medical Center.
This west Texas police agency has released few details surrounding the incident which took place on April 29, when police were called to respond to a burglary in Sanchez' neighborhood.
The fatal encounter did not take place at the residence that was allegedly burglarized however, and police will only say it was "different than the location he was suspected of burglarizing."
The victim's mother maintains that the shooting took place outside the home she shared with her son, after police arrived and asked her to come outside.
Erik Sanchez shouted in reply to the cops, which isn't illegal.
It remains unclear why the El Paso police officers went to the family's home in the first place.
The Mexican Consulate has also been involved with assisting the family, as Sanchez was a Mexican citizen who was living legally in the United States as many families whose lives straddle the border.
Mexico's Consul General Jacob Prado is calling for a full investigation of the incident.
The El Paso officer who shot Sanchez was placed on administrative leave for a few days following the incident. We all know that's just cop speak for paid vacation.
The officer is supposed to remain on administrative duties pending the outcome of the investigation by the Texas Rangers, the El Paso Police, and the District Attorney's office.
The investigation is anticipated to be complete by "early next year," according to Prado.
It is unknown at this time if the officer who shot Erik Garcia in the back is sipping margaritas by the pool today, but we know that El Paso taxpayers will probably wind up footing the bill for killing a man suspected of no crimes.
Texas Cops Beat and Taser Man after finding Antibiotics in his Car
EditorCarlos Miller
Watch: Footage Shows Atlanta Cop Stealing Cash from Homicide Victim
EditorKeith Palmer
WATCH: Witnesses Swarm New Orleans Police Arresting Brass Band Musician
EditorBen Keller
Tennessee Deputies Hold Man Down while Probing his Anus after Smelling Marijuana
WATCH: Florida Deputy Tackles and Punches Drunk Man Repeatedly
Iowa Sheriff: Local Cop should have been Charged for Attacking Man, not Hired
Atlanta Police Officer Fired for Stealing $500 from Dead Man's Pockets, Cops Say
WATCH: NYPD Cop Kneels on Man's Head, Pulls Gun on Witnesses Trying to Calm him
WATCH: New York Cops Shoot Armed Suspect Twice in Confrontation


Abstract: The purpose of this paper is to study reducibility properties in Sasakian geometry. First we give the Sasaki version of the de Rham decomposition theorem; however, we need a mild technical assumption on the Sasaki automorphism group which includes the toric case. Next we introduce the concept of cone reducible and consider bundles over a smooth projective algebraic variety where we give a classification result concerning contact structures admitting the action of a 2-torus of Reeb type. In particular, we can classify all such Sasakian structures up to contact isotopy on bundles over a Riemann surface of genus greater than zero. Finally, we show that in the toric case an extremal Sasaki metric on a Sasaki join always splits.
Charles P. Boyer and Craig van Coevering, Relative K-stability and extremal Sasaki metrics, Math. Res. Lett. 25 (2018), no. 1, 1-19.
[Thu79] W. Thurston, The geometry and topology of -manifolds, Mimeographed Notes, Princeton University, 1979.
W. Thurston, The geometry and topology of -manifolds, Mimeographed Notes, Princeton University, 1979.
Additional Notes: The first author was partially supported by a grant (#245002) from the Simons Foundation.
The third author was partially supported by France ANR project EMARKS No ANR-14-CE25-0010.
The fourth author was partially supported by grant #208799 from the Simons Foundation.


Despite ostensibly listening to the same track four times, I felt something unique hidden deep in 41st & Home's charity single, the Wilderness Eyes O.W.L. Remix Collection. While some may find the record paltry, sparse, or dull, it is in fact surprisingly varied, entertaining and well done. Oh, and how about the icing on the cake? All the proceeds go to the Orphaned Wildlife Rehabilitation Society, a non-profit aimed at helping birds of prey.
"But," you might say, "what about the actual music?" It's fresh. It's fun. "But it's only one new song, how is that possible?" Simply put, the three remixes that accompany the track are so original, it's easy to forget that they are, in fact, variations of the same song. "Wilderness Eyes" is a lush and dreamy melody featuring wonderful vocal harmonies by the whole band. But the standout from this gem of an EP is the group's rap remix entitled "2 Wilderness 4 yr Eyez," a hilarious attempt at suburban rapping with a light-hearted feel.
The remaining tracks are downtempo electronic re-imaginings, two relaxing experiences that, despite being subtle changes from the original, bring a feeling of peace and originality. 41st & Home are doing it right—not only are they raising money for a very unique cause, they're having fun and making some jovial music, and that deserves some attention.


The commercial real estate capital markets have recovered from the dark days of the global financial crisis bringing liquidity to Main Street, USA. Large balance loans delivering $25+ million to institutional and well-heeled private investors were the first market to recover.
Over the last 12 months the small balance market serving-up loans from $1 to $10 million has exploded flooding the market with liquidity.
While the borrowing rules are different from the go-go days of 2005-2006 capital has returned to Main Street!
The historic green benches of Central Avenue in Saint Petersburg, Florida. Main Street USA!
Contact David Repka or send e-mail to moc.laicnanifnosibnull@evad, and provide 8 to 10 bullet points on the opportunity.
Before you go, save some time by browsing our Sample Executive Summary and Loan Checklist and look for the downloadable PDFs.


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Current Treatments of Keratoconus
Transcript of Video by Christopher J. Rapuano, MD - Chief, Cornea Service Wills Eye Hospital
Hi, I'm Dr. Christopher Rapuano, Chief of the Cornea Service at Wills Eye Hospital in Philadelphia. I'm coming to you from the Wills Eye Alumni Society Newsroom at Wills Eye Hospital.
I'd like to talk for a little bit about a stepwise treatment to keratoconus. First of all, keratoconus is a relatively common condition. Depending on how it's defined, it's between perhaps 1 in 100 and 1 in 1,000 patients in the United States, and in some countries it's actually more common than that. It's a condition where the cornea, which is a clear covering of the eye, becomes thin and protruded or ectatic where it actually begins to bulge out a little bit, and that affects the vision. It's not a nice smooth cornea that can be corrected nicely with glasses, so that people's vision gets blurred with keratoconus. It tends to come on around the age of 15, 20, 25. It tends to progress until the ages of 35, 40, 45, and then it tends to stabilize.
One of the biggest risk factors for getting keratoconus is eye rubbing. So just like your grandmother told you, you should not rub your eyes, and it's good advice for preventing keratoconus from coming on or from keratoconus getting worse.
In mild cases of keratoconus, glasses can work or soft contact lenses, especially soft lenses that correct astigmatism. But for most people with keratoconus, they get their best vision with rigid gas permeable or hard contact lenses. If those don't work, sometimes you can go to a hybrid lens, which is a hard contact in the center with a soft skirt on the outside. If that doesn't work, sometimes you can go to a big scleral contact lens which kind of vaults over the entire cornea.
Some of these lenses are a little trickier to fit than just regular old soft lenses, so most keratoconus patients will seek out contact lens fitters that specialize in keratoconus lens fittings. They tend to have a higher success rate from contact lens specialists who do a lot of keratoconus lens fittings.
Some patients who don't do well with contacts can be treated with Intacs, which are little pieces of plastic, little plastic implants that are placed in the cornea. They can work on occasion, but I personally don't find them super helpful for a lot of patients. Some patients -- when their keratoconus is really terrible and contacts don't work, or they develop scarring from the contact lenses or from the keratoconus in and of itself -- they can go on to a cornea transplant, where either most of the cornea or the entire cornea can be replaced with a donor cornea. While transplants are big surgeries, they can work very well and people can function extremely well either with glasses or with contacts after transplants.
It's nice to know that corneal transplants for keratoconus have the highest success rate of all cornea transplants that we do, meaning the vast majority of people will get 20/40 or better vision with correction within a year after surgery, and that vision remains good for decades.
The newest kid on the block as far as treatment of keratoconus is something called corneal crosslinking or collagen crosslinking. This is a procedure which was developed in Europe about 15 years ago, became somewhat widely used about 10 years ago, but five years ago really gained wide acceptance around the world. In the U.S., because of a slower regulatory system, crosslinking was not approved until last year. But now it's available and is being done throughout the United States. I and my partners at Wills Eye were involved in one of the FDA studies for collagen crosslinking several years ago with very good results. And now that it's FDA-approved, we are performing crosslinking for our keratoconus patients. There are numerous techniques for crosslinking, and we are performing the FDA-approved technique.
The idea behind crosslinking is that it is used for patients where the keratoconus is getting worse, it's progressing, and the crosslinking procedure can actually halt the progression of keratoconus. That's the idea. Because if you can stop keratoconus where someone is doing well with soft contact lenses or with hard contact lenses, and it doesn't get worse, ideally they can continue with those lenses throughout their lives. Whereas if it progresses and progresses, they may not be able to wear contact lenses and move on to a cornea transplant later on -- which of course is not ideal. Crosslinking is really becoming the standard of care in the United States, now that it is FDA approved, for patients with progressive keratoconus. These tend to be patients between the ages of 15 and 25, 30, 35. Fortunately, most patients over the age of 35, 40, 45 the keratoconus is no longer progressing and they don't need to have this procedure.
If you have keratoconus or suspect you have keratoconus, you should certainly see your eye care provider. There are certain evaluations that can be done, and then if you're not sure if it's progressing those evaluations can be repeated over time. And if they're nice and stable, crosslinking may not be so beneficial to you. But if the keratoconus appears to be getting worse and worse and worse, we would like to catch that earlier rather than later to prevent it from becoming very bad.
That's been kind of a whirlwind overview of the current treatments of keratoconus.
I'm Dr. Christopher Rapuano, Chief of the Cornea Service at Wills Eye Hospital coming to you from the Wills Eye Alumni Society Newsroom at Wills Eye Hospital in Philadelphia, Pennsylvania. Thank you very much.
Progressive central/inferocentral corneal thinning and irregularity. It usually develops during teenage or young adulthood years, but can occur later. Almost always bilateral but typically asymmetric.
Decreased vision, frequent change in glasses.
The cause is unknown, but eye rubbing is thought to be a factor in some patients.
Eye rubbing, ocular allergies, occasionally runs in families.
Corneal scarring, acute hydrops (break in Descemet's membrane resulting in the sudden development of mild or severe corneal edema causing pain, redness and poor vision).
Tests and Diagnosis
Slit lamp examination is essential. Corneal topography and tomography are extremely helpful in identifying mild cases. They are quite useful in monitoring for progression of the condition.
Stepwise approach depends on severity, beginning with glasses, soft contact lenses, toric soft contact lenses, rigid gas permeable contact lenses, hybrid lenses, scleral lenses (including the PROSE lens). Patients who are contact lens intolerant can be treated with INTACS or corneal transplantation such as a deep anterior lamellar keratoplasty or a full thickness corneal transplant. Corneal crosslinking should be considered in eyes with progressive corneal steepening/thinning. All patients should be counseled not to rub their eyes. Ocular allergies should also be treated to reduce the impetus for eye rubbing.
Support: KCN support websites.
NO eye rubbing! Corneal crosslinking can prevent progression.
Keratoconus Photos
View Subspecialties
Christopher J. Rapuano, MD
Specialty: Cornea, Refractive Surgery
Brandon D. Ayres, MD
Specialty: Cornea
View Doctors


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Главная > Research
Page is under construction
The Children of Islamic State (Діти Ісламської Держави)
Дослідження наших партнерів по європейській коаліції «Partnership Against the online RadIcalization of Youth Subjects».
Summary of the study "Extremism in Ukraine 2015- 2016″
Please, be aware that it is only summary of the study "Extremism in Ukraine 2015- 2016″ full version see in Ukrainian.
The situation in the Ukrainian society still remains vulnerable to external influence: among the main impulses is the direct threat of military intervention as well as the end to financial and other assistance from the West. Indirect threats include moving of the Ukrainian problems to the background on the world agenda and the appearing of new "hot spots" on the Ukrainian border. The last ones (in particular, the potential reelections in Moldova) allow Russia indirectly influence the internal situation in Ukraine (especially it refers to a safe environment in the Odessa region) without the threat of sanction prolongation for an aggressor-country. Read more
The Northern Ireland Peace Process – Lessons for Ukraine. Research Intern of UIRE
Bernhard Schneider undertook 3weeks internship at the UIRE. He is currently studying World Politics at the Leiden University College in The Hague. The result of his internship is researching: "The Northern Ireland Peace Process – Lessons for Ukraine". Read more
Civilian weapons: myths and facts (announcement of the research)
A significant level of distrust of the population to the state's ability to protect, stimulate to other security sources and tools. Already today, almost half the population admitted such phenomenon as lynching. Read more
CHILDREN OF WAR: Research on problems of childhood in Ukraine in conditions of military aggression
Children of war (PDF)
Other researchs
The situation in the Ukrainian society still remains vulnerable to external influence: among the main impulses is the direct threat of military intervention as well as the end to financial and other assistance from the West. Indirect threats include moving of the Ukrainian problems to the background on the world agenda and the appearing of new "hot spots" on the Ukrainian border. The last ones (in particular, the potential reelections in Moldova) allow Russia indirectly influence the internal situation in Ukraine (especially it refers to a safe environment in the Odessa region) without the threat of sanction prolongation for an aggressor-country. (more…)
Bernhard Schneider undertook 3weeks internship at the UIRE. He is currently studying World Politics at the Leiden University College in The Hague. The result of his internship is researching: "The Northern Ireland Peace Process – Lessons for Ukraine". (more…)


There are many things going on which has prevented me from blogging consistently. In the end of January, I came under care of the Central Florida Presbytery. It is my first step towards ordination in the Presbyterian Church in America.
My primary intention is to be licensed in April when the presbytery meets again. License examination includes a few written exams and oral exams on the topics of Theology, the Westminster Confession, and the Book of Church Order (BCO).
At the same time, I continue to serve at New Life Presbyterian where I have been for almost three years. My time at New Life has been a marvelous introduction to pastoral work.
Though I am finished with all my classes in seminary, I am concluding a virtual class called Judges to Poets taught by Dr. John Currid. My intention is to have completed all my seminary requirements by the end of this month.
Blessings, Uri. I wish you well.


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Amazon Offering Employees $10K Incentive to Quit and Start Their Own Delivery Businesses
In the past several years, Amazon employees have often expressed disgruntlement about how the company treated them. Some of the complaints have seemed legitimate, some merely the logical response to the company becoming the financial giant that it is.
Now, Amazon is taking its money and offering its entrepreneurial-minded employees a great opportunity:
Amazon offering employees $10K to quit, start delivery businesses https://t.co/ZWXGeWJUy6 pic.twitter.com/TMy592Q9rU
— Eyewitness News (@ABC7NY) May 13, 2019
More from abc7ny.com:
The offer, announced Monday, comes as Amazon seeks to speed up its shipping time from two days to one for its Prime members. The company sees the new incentive as a way to get more packages delivered to shoppers' doorsteps faster.
Amazon says it will cover up to $10,000 in startup costs for employees who are accepted into the program and leave their jobs. The company says it will also pay them three months' worth of their salary.
The offer is open to most part-time and full-time Amazon employees, including warehouse workers who pack and ship orders. Whole Foods employees are not eligible to receive the new incentives.
According to the article, this is an expansion of a program begun last year, and is part of an effort by Amazon to be in greater control of its deliveries.
One employee who took advantage of the original version of the program less than a year ago is already having great success:
One of them is run by Milton Collier, a freight broker who started his business in Atlanta about eight months ago. Since then, it has grown to 120 employees with a fleet of 50 vans that can handle up to 200 delivery stops in a day. It has already been preparing for the one-day shipping switch by hiring more people.
As opportunities for entering into the business world go, this seems a lot better than incurring hundreds of thousands of dollars of college debt before ever going on an interview.
https://pjmedia.com/trending/amazon-offering-employees-10k-incentive-to-quit-and-start-their-own-delivery-businesses/
Related: entrepreneurship, Amazon


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EVs Defined: The Different Types and Their Advantages
You've begun the process of searching for your future EV, but you've come across confusing terms. HEV, PHEV, and BEV - which one best suits your needs? We'll walk you through the different types of electric vehicles and highlight the advantages and disadvantages of each.
Before beginning a discussion on EVs, we will take a moment to consider that the majority of vehicles on the road today use gasoline or diesel as their primary fuel source. Gasoline burning vehicles utilize what is referred to as an Internal Combustion Engine (ICE). This type of power plant is popular throughout the world and can be found in both commercial and residential use. ICEs have continuously become more efficient and have served as a bridge between hybrids and fully electric vehicles.
Hybrid Electric Vehicles (HEVs) are a type of hybrid that combines a conventional internal combustion engine with an electric motor to propel the vehicle. The HEV does not have the ability to plug in and be charged. Its battery receives a charge from the vehicle's regenerative braking system and the ability to charge the vehicle battery using the gas engine.
The regenerative braking system mentioned above is a feature unique to all types of EV. It provides a charge to the battery allowing the vehicle to recover energy during deceleration. That energy is converted into electricity, which can be either used immediately or stored until needed.
Some examples of HEV type vehicles are the Toyota Prius, Ford Fusion hybrid, and the Honda Civic hybrid.
What makes the HEV unique? : HEVs are built for a more conventional driver to get better fuel economy. It does not require a plug to charge the battery system.
What it has in common with other EV types: The HEV uses a similar gas engine and electric motor combination to the PHEV. Additionally, the HEV utilizes regenerative braking much like the PHEV and BEV allowing for additional charging opportunities.
Is this a good car for me? Hybrid electric vehicles are best suited for drivers looking to achieve increased fuel economy compared to traditional ICE vehicles while decreasing their vehicles emissions.
Plug-in Hybrid Electric Vehicles (PHEVs) are very similar to HEVs as they have a gas engine and rechargeable batteries. A key difference is that PHEV batteries can be restored to full charge by connecting to a charging station. This allows the PHEV user to run their vehicle solely on electric or gas.. Additionally, some PHEV models have the ability to recharge the battery using the gas engine.
PHEVs also have a larger all-electric range as compared to an HEV due to a larger battery. In many PHEV models the gas engine serves to provide additional range, however some models can be driven exclusively on gas similar to a HEV.
Some examples of PHEV type vehicles are the Chevrolet Volt, Ford Fusion Energi, and the BMW i8.
What makes the PHEV unique? It can be driven as a hybrid or a battery electric vehicle in all-electric mode. When driving a PHEV all electric, a major benefit is the elimination of range anxiety as the vehicle will also run on gasoline. This combination offers an increased range and an even greater cost savings.
What it has in common with other EV types: The PHEV uses a similar gas engine and electric motor combination as the HEV. Additionally, the PHEV utilizes regenerative braking much like the HEV and BEV.
Is this a good car for me? Plug-in hybrid electric vehicles are best suited for drivers looking to reduce emissions and save on fuel costs. PHEVs allow users to drive a zero emission vehicle with the flexibility to travel long distances gasoline.
Battery Electric Vehicles (BEVs) are a non-hybrid type vehicle fitted with an electric motor and a large capacity battery. BEVs are 100% electric, which alleviates the need for a gas engine. BEVs receive charge to their batteries through a charging station and regenerative braking. Some EV models have a range of more than 200 miles.
Some examples of BEV type vehicles would be the Chevy Bolt EV ,the BMW i3, the Volkswagen e-Golf, and the Nissan Leaf.
What makes the BEV unique? BEV type vehicle run entirely on electric power alone and emit zero emissions. This eliminates fossil fuel dependence and alleviates a significant amount of maintenance costs commonly incurred on ICE-type vehicles.
What it has in common with other BEV types: Similar to the HEV and PHEV, the BEV also utilizes a regenerative braking system to capture additional charge opportunities.
Is this a good car for me? Battery electric vehicles are best suited for drivers who want to be 100% free from using a gasoline engine. Consider how many miles you drive on an average day and select an EV with a maximum range at least 50 percent more than that. For example if you commute 40 miles round-trip, select an EV with a range of at least 60 miles. Charging fully at night and at work, if available, can help extend your daily range and keep you all electric.
Test Author
Dual Bollard
EVo Reel
history of electric vehicles
leaf charger
Power Max
Power Max 2
Power Xpress
types of electric vehicles
volt charger


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Interesting facts about pheasants
Pheasant a large long-tailed game bird.
There are about 50 species of pheasant.
Their native range is restricted to Asia.
Several species have been naturalized elsewhere—two thousand years ago or so in Anatolia and Europe — and many are prized as ornamentals in zoos and private collections; they are also raised for sport in shooting preserves.
The best-known is the common pheasant, which is widespread throughout the world, it is one of the world's most hunted birds. Various other pheasant species are popular in aviaries, such as the golden pheasant (Chrysolophus pictus).
Pheasant habitat would include a combination of grasslands, idle fields, wetlands, croplands, haylands, and shrublands.
The lifespan of a pheasant is about 1-3 years in the wild and up to 18 years in captivity.
Pheasants are characterised by strong sexual dimorphism, males being highly decorated with bright colors and adornments such as wattles.
The adult male common pheasant is 60–90 cm (24–35 in) in length with a long brown streaked black tail, accounting for almost 50 cm (20 in) of the total length.
The female (hen) is much less showy, with a duller mottled brown plumage all over and measuring 50–63 cm (20–25 in) long including a tail of around 20 cm (7.9 in).
There are many color forms of the male common pheasant, ranging in color from nearly white to almost black in some melanistic examples.
While common pheasants are able short-distance fliers, they prefer to run. If startled however, they can suddenly burst upwards at great speed, with a distinctive "whirring" wing sound and often giving kok kok kok calls to alert conspecifics. Their flight speed is up to 60 km/h (37 mph) when cruising but when chased they can fly up to 90 km/h (56 mph).
When startled, common pheasants rise almost vertically with a loud whirring of wings.
Pheasants are diurnal (active during the day).
They are omnivores with diet varying by season. Pheasants eat a wide variety of animal and vegetable type-food, like fruit, seeds, grain, mast, berries and leaves as well as a wide range of invertebrates, such as leatherjackets, ant eggs, wireworms, caterpillars, grasshoppers and other insects; with small vertebrates like lizards, field voles, small mammals, and small birds occasionally taken.
Common pheasants are social birds. In the autumn, they flock together, sometimes in large groups in areas with food and cover. Usually the core home range is smaller in the winter than during the nesting season. Flocks formed in the winter may have up to 50 pheasants.
Common pheasants are polygynous, with a single male having a harem of several females. Common pheasants breed seasonally. They produce a clutch of around 8-15 eggs; they are pale olive in color, and laid over a 2–3 week period in April to June. The incubation period is about 22–27 days. The chicks stay near the hen for several weeks, yet leave the nest when only a few hours old. After hatching they grow quickly, flying after 12–14 days, resembling adults by only 15 weeks of age.
Pheasants have a number of natural predators in the wild, although the human tends to be the most common predator of the pheasant as they are hunted for their meat and feathers.
According to the Oxford English Dictionary, the word "pheasant" ultimately comes from Phasis, the ancient name of what is now called the Rioni River in Georgia. It passed from Greek to Latin to French (spelled with an initial "f") then to English, appearing for the first time in English around the year 1299.
In the US, common pheasants are widely known as "ring-necked pheasants". More colloquial North American names include "chinks" or, in Montana, "phezzens".
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